TY - JOUR T1 - Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium. AN - 1869069415; 28205047 AB - PURPOSE Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results. METHODS We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis IGF-I concentrations and subsequent risk of EOC. We evaluated IGF-I concentrations and risk of EOC overall and by tumor subtype (defined by histology, grade, stage) in 1,270 cases and 2,907 matched controls. Multivariable conditional logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS Doubling of IGF-I concentration was associated with significantly lower risk of overall EOC [ORlog2 = 0.82; CI 0.72-0.93]. We observed no heterogeneity by tumor characteristics (e.g., histology, p het = 0.62), menopausal status at blood collection (p het = 0.79), or age at diagnosis (p het = 0.60). CONCLUSIONS These results suggest that IGF-I concentrations are inversely associated with EOC risk, independent of histological phenotype. Future prospective research should consider potential mechanisms for this association, including, considering other members of the IGF-family to better characterize the role of IGF-signaling in the etiology of EOC. JF - Cancer causes & control : CCC AU - Ose, Jennifer AU - Schock, Helena AU - Poole, Elizabeth M AU - Lehtinen, Matti AU - Visvanathan, Kala AU - Helzlsouer, Kathy AU - Buring, Julie E AU - Lee, I-Min AU - Tjønneland, Anne AU - Boutron-Ruault, Marie-Christine AU - Trichopoulou, Antonia AU - Mattiello, Amalia AU - Onland-Moret, N Charlotte AU - Weiderpass, Elisabete AU - Sánchez, María-José AU - Idahl, Annika AU - Travis, Ruth C AU - Rinaldi, Sabina AU - Merritt, Melissa A AU - Wentzensen, Nicolas AU - Tworoger, Shelley S AU - Kaaks, Rudolf AU - Fortner, Renée T AD - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Baden-Württemberg, Germany. ; Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. ; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden. ; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ; Division of Preventive Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. ; Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark. ; Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France. ; Hellenic Health Foundation, Athens, Greece. ; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. ; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. ; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. ; Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. ; Department of Clinical Sciences, Obstetrics and Gynecology, Umea University, Umea, Sweden. ; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. ; Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France. ; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. ; Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. ; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Baden-Württemberg, Germany. r.fortner@dkfz-heidelberg.de. Y1 - 2017/02/16/ PY - 2017 DA - 2017 Feb 16 KW - Developmental pathways KW - IGF-I KW - Histological subtypes KW - Epithelial ovarian cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1869069415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Pre-diagnosis+insulin-like+growth+factor-I+and+risk+of+epithelial+invasive+ovarian+cancer+by+histological+subtypes%3A+A+collaborative+re-analysis+from+the+Ovarian+Cancer+Cohort+Consortium.&rft.au=Ose%2C+Jennifer%3BSchock%2C+Helena%3BPoole%2C+Elizabeth+M%3BLehtinen%2C+Matti%3BVisvanathan%2C+Kala%3BHelzlsouer%2C+Kathy%3BBuring%2C+Julie+E%3BLee%2C+I-Min%3BTj%C3%B8nneland%2C+Anne%3BBoutron-Ruault%2C+Marie-Christine%3BTrichopoulou%2C+Antonia%3BMattiello%2C+Amalia%3BOnland-Moret%2C+N+Charlotte%3BWeiderpass%2C+Elisabete%3BS%C3%A1nchez%2C+Mar%C3%ADa-Jos%C3%A9%3BIdahl%2C+Annika%3BTravis%2C+Ruth+C%3BRinaldi%2C+Sabina%3BMerritt%2C+Melissa+A%3BWentzensen%2C+Nicolas%3BTworoger%2C+Shelley+S%3BKaaks%2C+Rudolf%3BFortner%2C+Ren%C3%A9e+T&rft.aulast=Ose&rft.aufirst=Jennifer&rft.date=2017-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=1573-7225&rft_id=info:doi/10.1007%2Fs10552-017-0852-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-02-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-17 DO - http://dx.doi.org/10.1007/s10552-017-0852-8 ER - TY - JOUR T1 - Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles. AN - 1867538710; 28187746 AB - BACKGROUND Concerns have been expressed that inhaled nanoparticles may behave differently to larger particles in terms of lung clearance and translocation, with potential implications for their toxicity. Studies undertaken to investigate this have typically involved limited post-exposure periods. There is a shortage of information on longer-term clearance and translocation patterns and their dependence on particle size, which this study aimed to address. METHODS Rats were exposed (<3 h) nose-only to aerosols of spark-generated radioactive iridium-192 nanoparticles of four sizes: 10 nm, 15 nm, 35 nm and 75 nm (count median diameter) (aerosol mass concentrations 17, 140, 430, and 690 μg/m3, respectively). The content of iridium-192 in the whole animal, organs, tissues, and excreta was measured at various times post-exposure to ≥ 1 month. Limited toxicological investigations were undertaken for the 10 nm aerosol using bronchoalveolar lavage fluid. Elemental maps of tissue samples were produced using laser ablation inductively coupled plasma mass spectrometry and synchrotron micro-focus x-ray fluorescence. The chemical speciation of the iridium was explored using synchrotron micro focus x-ray near-edge absorption spectroscopy. RESULTS Long-term lung retention half-times of several hundred days were found, which were not dependent on particle size. There was significant variation between individual animals. Analysis of bronchoalveolar lavage fluid for the 10 nm aerosol indicated a limited inflammatory response resolving within the first 7 days. Low levels of, particle size dependent, translocation to the kidney and liver were found (maximum 0.4% of the lung content). Any translocation to the brain was below the limits of detection (i.e. < 0.01% of the lung content). The kidney content increased to approximately 30 days and then remained broadly constant or decreased, whereas the content in the liver increased throughout the study. Laser ablation inductively coupled plasma mass spectrometry analysis indicated homogeneous iridium distribution in the liver and within the cortex in the kidney. CONCLUSIONS Slow lung clearance and a pattern of temporally increasing concentrations in key secondary target organs has been demonstrated for inhaled iridium aerosol particles < 100 nm, which may have implications for long-term toxicity, especially in the context of chronic exposures. JF - Particle and fibre toxicology AU - Buckley, Alison AU - Warren, James AU - Hodgson, Alan AU - Marczylo, Tim AU - Ignatyev, Konstantin AU - Guo, Chang AU - Smith, Rachel AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0RQ, UK. ; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK. ; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0RQ, UK. rachel.smith@phe.gov.uk. Y1 - 2017/02/10/ PY - 2017 DA - 2017 Feb 10 SP - 5 VL - 14 IS - 1 KW - Rat KW - Tissue distribution KW - Lung clearance KW - Toxicity KW - Inhalation exposure KW - In vivo study KW - Nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1867538710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Slow+lung+clearance+and+limited+translocation+of+four+sizes+of+inhaled+iridium+nanoparticles.&rft.au=Buckley%2C+Alison%3BWarren%2C+James%3BHodgson%2C+Alan%3BMarczylo%2C+Tim%3BIgnatyev%2C+Konstantin%3BGuo%2C+Chang%3BSmith%2C+Rachel&rft.aulast=Buckley&rft.aufirst=Alison&rft.date=2017-02-10&rft.volume=14&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2Fs12989-017-0185-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-02-11 N1 - Date revised - 2017-02-14 N1 - Last updated - 2017-02-14 DO - http://dx.doi.org/10.1186/s12989-017-0185-5 ER - TY - JOUR T1 - Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned with Heliotropium europaeum. AN - 1862767063; 28125883 AB - Pyrrolizidine alkaloids are among the most common poisonous plants affecting livestock, wildlife, and humans. Exposure of humans and livestock to toxic pyrrolizidine alkaloids through the intake of contaminated food and feed may result in poisoning, leading to devastating epidemics. During February 2014, 73 mixed breed female beef cows from the Galilee region of Israel were accidently fed pyrrolizidine alkaloid contaminated hay for 42 days, resulting in the sudden death of 24 cows over a period of 63 days. The remaining cows were slaughtered 2.5 months after the last ingestion of the contaminated hay. In this study, we report the histopathological analysis of the livers from five of the slaughtered cows and quantitation of pyrrolizidine alkaloid-derived DNA adducts from their livers and three livers of control cows fed with feed free of weeds producing pyrrolizidine alkaloids. Histopathological examination revealed that the five cows suffered from varying degrees of bile duct proliferation, fibrosis, and megalocytosis. Selected reaction monitoring HPLC-ES-MS/MS analysis indicated that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts were formed in all five livers. The livers from the three control cows did not have any liver damage nor any indication of DHP-DNA adduct formed. These results confirm that the toxicity observed in these cattle was caused by pyrrolizidine alkaloid poisoning and that pyrrolizidine alkaloid-derived DNA adducts could still be detected and quantified in the livers of the chronically poisoned cows 2.5 months after their last exposure to the contaminated feed, suggesting that DHP-derived DNA adducts can serve as biomarkers for pyrrolizidine alkaloid exposure and poisoning. JF - Chemical research in toxicology AU - Fu, Peter P AU - Xia, Qingsu AU - He, Xiaobo AU - Barel, Shimon AU - Edery, Nir AU - Beland, Frederick A AU - Shimshoni, Jakob A AD - National Center for Toxicological Research , Jefferson, Arkansas 72079, United States. ; Department of Toxicology, Kimron Veterinary Institute , 50250 Bet Dagan, Israel. ; Department of Pathology, Kimron Veterinary Institute , 50250 Bet Dagan, Israel. Y1 - 2017/02/10/ PY - 2017 DA - 2017 Feb 10 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862767063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Detection+of+Pyrrolizidine+Alkaloid+DNA+Adducts+in+Livers+of+Cattle+Poisoned+with+Heliotropium+europaeum.&rft.au=Fu%2C+Peter+P%3BXia%2C+Qingsu%3BHe%2C+Xiaobo%3BBarel%2C+Shimon%3BEdery%2C+Nir%3BBeland%2C+Frederick+A%3BShimshoni%2C+Jakob+A&rft.aulast=Fu&rft.aufirst=Peter&rft.date=2017-02-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00456 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-27 N1 - Date revised - 2017-02-13 N1 - Last updated - 2017-02-13 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00456 ER - TY - JOUR T1 - Pharmacokinetic Profile of Oral Cannabis in Humans: Blood and Oral Fluid Disposition and Relation to Pharmacodynamic Outcomes. AN - 1865528789; 28158482 JF - Journal of analytical toxicology AU - Vandrey, Ryan AU - Herrmann, Evan S AU - Mitchell, John M AU - Bigelow, George E AU - Flegel, Ronald AU - LoDico, Charles AU - Cone, Edward J AD - Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr., Baltimore, MD 21224, USA. ; Columbia University & the New York State Psychiatric Institute, 1051 Riverside Drive, Unit#120, New York, NY 10032, USA. ; RTI International, 3040 East Cornwallis Rd., Research Triangle Park, NC 27709, USA. ; Substance Abuse and Mental Health Services Administration (SAMHSA), Division of Workplace Programs (DWP), 5600 Fishers Lane, Rockville, MD 20857, USA. Y1 - 2017/02/03/ PY - 2017 DA - 2017 Feb 03 SP - 1 EP - 17 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1865528789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Pharmacokinetic+Profile+of+Oral+Cannabis+in+Humans%3A+Blood+and+Oral+Fluid+Disposition+and+Relation+to+Pharmacodynamic+Outcomes.&rft.au=Vandrey%2C+Ryan%3BHerrmann%2C+Evan+S%3BMitchell%2C+John+M%3BBigelow%2C+George+E%3BFlegel%2C+Ronald%3BLoDico%2C+Charles%3BCone%2C+Edward+J&rft.aulast=Vandrey&rft.aufirst=Ryan&rft.date=2017-02-03&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbkx012 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-02-03 N1 - Date revised - 2017-02-07 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1093/jat/bkx012 ER - TY - JOUR T1 - Non-malignant respiratory disease among workers in industries using styrene-A review of the evidence AN - 1868327840; PQ0004034723 AB - Background Asthma and obliterative bronchiolitis (OB) cases have occurred among styrene-exposed workers. We aimed to investigate styrene as a risk factor for non-malignant respiratory disease (NMRD). Methods From a literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (i.e., strong, intermediate, suggestive, none) between styrene exposure and NMRD-related morbidity and mortality. Results We analyzed 55 articles and two unpublished case reports. Ten OB cases and eight asthma cases were identified. Six (75%) asthma cases had abnormal styrene inhalation challenges. Thirteen (87%) of 15 cross-sectional studies and 12 (50%) of 24 mortality studies provided at least suggestive evidence that styrene was associated with NMRD-related morbidity or mortality. Six (66%) of nine mortality studies assessing chronic obstructive pulmonary disease-related mortality indicated excess mortality. Conclusions Available evidence suggests styrene exposure is a potential risk factor for NMRD. Additional studies of styrene-exposed workers are warranted. Am. J. Ind. Med. 60:163-180, 2017. JF - American Journal of Industrial Medicine AU - Nett, Randall J AU - Cox-Ganser, Jean M AU - Hubbs, Ann F AU - Ruder, Avima M AU - Cummings, Kristin J AU - Huang, Yuh-Chin T AU - Kreiss, Kathleen AD - Respiratory Health Division, Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 163 EP - 180 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 2 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868327840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Non-malignant+respiratory+disease+among+workers+in+industries+using+styrene-A+review+of+the+evidence&rft.au=Nett%2C+Randall+J%3BCox-Ganser%2C+Jean+M%3BHubbs%2C+Ann+F%3BRuder%2C+Avima+M%3BCummings%2C+Kristin+J%3BHuang%2C+Yuh-Chin+T%3BKreiss%2C+Kathleen&rft.aulast=Nett&rft.aufirst=Randall&rft.date=2017-02-01&rft.volume=60&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22655 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/ajim.22655 ER - TY - JOUR T1 - Cancer incidence among capacitor manufacturing workers exposed to polychlorinated biphenyls AN - 1868324402; PQ0004034724 AB - Background We evaluated cancer incidence in a cohort of polychlorinated biphenyl (PCB) exposed workers. Methods Incident cancers, identified using state registries, were compared to those in a national population using standardized incidence ratios. Trends in prostate cancer incidence with cumulative PCB exposure were evaluated using standardized rate ratios and Cox regression models. For selected sites, cumulative PCB exposure was compared between aggressive (fatal/distant stage) and localized/regional cancers. Results We identified 3,371 invasive first primary cancer diagnoses among 21,317 eligible workers through 2007. Overall relative incidence was reduced. Elevations were only observed for respiratory cancers and among women, urinary organ cancers. Among men, prostate cancer incidence was reduced and not associated with cumulative PCB exposure although median exposures were significantly higher for aggressive compared to localized/regional prostate cancers. Conclusion Previously observed associations between cumulative PCB exposure and prostate cancer mortality were not confirmed in this analysis; prostate cancer stage at diagnosis may explain the discrepancy. Am. J. Ind. Med. 60:198-207, 2017. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Ruder, Avima M AU - Hein, Misty J AU - Hopf, Nancy B AU - Waters, Martha A AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 198 EP - 207 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 2 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Workers KW - Invasiveness KW - polychlorinated biphenyls KW - Prostate cancer KW - Regression analysis KW - PCB KW - Models KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868324402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Cancer+incidence+among+capacitor+manufacturing+workers+exposed+to+polychlorinated+biphenyls&rft.au=Ruder%2C+Avima+M%3BHein%2C+Misty+J%3BHopf%2C+Nancy+B%3BWaters%2C+Martha+A&rft.aulast=Ruder&rft.aufirst=Avima&rft.date=2017-02-01&rft.volume=60&rft.issue=2&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22657 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Workers; Mortality; Invasiveness; Prostate cancer; polychlorinated biphenyls; Regression analysis; PCB; Models DO - http://dx.doi.org/10.1002/ajim.22657 ER - TY - JOUR T1 - The new ANSI nail gun standard: A lost opportunity for safety AN - 1868324140; PQ0004034725 AB - Pneumatic nail guns have been shown in published studies to cause injury and death to both workers and consumers, but those equipped with sequential trigger mechanisms provide much greater safety protection against unintentional discharge than those equipped with contact triggers. In 2015 the American National Standards Institute (ANSI) approved a revision to its 2002 nail gun standard, but failed to require sequential triggers. Substantive and procedural deficiencies in the ANSI standard's development process resulted in a scientifically unsound nail gun safety standard, detracting from its use as the basis for a mandatory national safety standard and ultimately from its ability to protect worker and consumer users. Am. J. Ind. Med. 60:147-151, 2017. JF - American Journal of Industrial Medicine AU - Howard, John AU - Branche, Christine M AU - Earnest, GScott AD - Office of the Director, National Institute for Occupational Safety and Health, Washington, District of Columbia. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 147 EP - 151 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 2 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868324140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=The+new+ANSI+nail+gun+standard%3A+A+lost+opportunity+for+safety&rft.au=Howard%2C+John%3BBranche%2C+Christine+M%3BEarnest%2C+GScott&rft.aulast=Howard&rft.aufirst=John&rft.date=2017-02-01&rft.volume=60&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22673 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/ajim.22673 ER - TY - JOUR T1 - Surface coating and matrix effect on the electrophoretic mobility of gold nanoparticles: a capillary electrophoresis-inductively coupled plasma mass spectrometry study AN - 1868323646; PQ0004063586 AB - Capillary electrophoresis (CE) is considered as a versatile technique in the size-based separation and speciation of nanomaterials. The electrophoretic mobility is determined by charge and size of an analyte which are affected by the surface composition of nanomaterials. Size-dependent differential electrophoretic mobility is used as a mechanism for size-based separation of nanoparticles. Understanding the effect of surface chemistry on the electrophoretic mobility of nanomaterials in CE is critical in obtaining accurate results in retention-based size calculation. A suite of gold nanoparticles (NPs) varied in sizes with different coatings, including citric acid (CA), lipoic acid (LA), tannic acid (TA), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), branched polyethyleneimine (BPEI), and bovine serum albumin (BSA), were selected to evaluate their impact to the migration pattern of gold NPs. Additionally, surface-coated gold NPs dispersed in Suwannee River humic acid (SRHA) solution and fetal bovine serum (FBS) were used to investigate the matrix effect. It was found that the correlation between NP size and relative electrophoretic mobility is highly dependent on the capping agents. The matrix component in the SRHA solution only exhibited limited influence to the migration of NPs while electrophoretic behaviors were drastically altered in the presence of FBS matrix. JF - Analytical and Bioanalytical Chemistry AU - Qu, Haiou AU - Linder, Sean W AU - Mudalige, Thilak K AD - 0000 0001 2243 3366, grid.417587.8, Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA, Thilak.Mudalige@fda.hhs.gov Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 979 EP - 988 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 409 IS - 4 SN - 1618-2642, 1618-2642 KW - Biotechnology and Bioengineering Abstracts KW - Rivers KW - Speciation KW - polyvinylpyrrolidone KW - Electrophoretic mobility KW - Migration KW - Mass spectroscopy KW - Lipoic acid KW - polyethyleneimine KW - Bovine serum albumin KW - Humic acids KW - capillary electrophoresis KW - Gold KW - Tannic acid KW - Polyethylene glycol KW - nanoparticles KW - Citric acid KW - Coatings KW - nanotechnology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868323646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Surface+coating+and+matrix+effect+on+the+electrophoretic+mobility+of+gold+nanoparticles%3A+a+capillary+electrophoresis-inductively+coupled+plasma+mass+spectrometry+study&rft.au=Qu%2C+Haiou%3BLinder%2C+Sean+W%3BMudalige%2C+Thilak+K&rft.aulast=Qu&rft.aufirst=Haiou&rft.date=2017-02-01&rft.volume=409&rft.issue=4&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-016-0012-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Number of references - 37 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Rivers; Speciation; polyvinylpyrrolidone; Electrophoretic mobility; Migration; Lipoic acid; Mass spectroscopy; polyethyleneimine; Bovine serum albumin; Humic acids; capillary electrophoresis; Gold; Tannic acid; nanoparticles; Polyethylene glycol; nanotechnology; Coatings; Citric acid DO - http://dx.doi.org/10.1007/s00216-016-0012-0 ER - TY - JOUR T1 - The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice AN - 1868322789; PQ0004095372 AB - Pyrrolizidine alkaloid (PA)-containing plants are widespread in the world and the most common poisonous plants affecting livestock, wildlife, and humans. Our previous studies demonstrated that PA-derived DNA adducts can potentially be a common biological biomarker of PA-induced liver tumor formation. In order to validate the use of these PA-derived DNA adducts as a biomarker, it is necessary to understand the basic kinetics of the PA-derived DNA adducts formed in vivo. In this study, we studied the dose-dependent response and kinetics of PA-derived DNA adduct formation and removal in male ICR mice orally administered with a single dose (40 mg/kg) or multiple doses (10 mg/kg/day) of retrorsine, a representative carcinogenic PA. In the single-dose exposure, the PA-derived DNA adducts exhibited dose-dependent linearity and persisted for up to 4 weeks. The removal of the adducts following a single-dose exposure to retrorsine was biphasic with half-lives of 9 h (t sub(1/2 alpha )) and 301 h (~12.5 days, t sub(1/2 beta )). In the 8-week multiple exposure study, a marked accumulation of PA-derived DNA adducts without attaining a steady state was observed. The removal of adducts after the multiple exposure also demonstrated a biphasic pattern but with much extended half-lives of 176 h (~7.33 days, t sub(1/2 alpha )) and 1736 h (~72.3 days, t sub(1/2 beta )). The lifetime of PA-derived DNA adducts was more than 8 weeks following the multiple-dose treatment. The significant persistence of PA-derived DNA adducts in vivo supports their role in serving as a biomarker of PA exposure. JF - Archives of Toxicology AU - Zhu, Lin AU - Xue, Junyi AU - Xia, Qingsu AU - Fu, Peter P AU - Lin, Ge AD - 0000 0004 1937 0482, grid.10784.3a, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China, peter.fu@fda.hhs.gov Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 949 EP - 965 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 91 IS - 2 SN - 0340-5761, 0340-5761 KW - Health & Safety Science Abstracts; Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868322789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=The+long+persistence+of+pyrrolizidine+alkaloid-derived+DNA+adducts+in+vivo%3A+kinetic+study+following+single+and+multiple+exposures+in+male+ICR+mice&rft.au=Zhu%2C+Lin%3BXue%2C+Junyi%3BXia%2C+Qingsu%3BFu%2C+Peter+P%3BLin%2C+Ge&rft.aulast=Zhu&rft.aufirst=Lin&rft.date=2017-02-01&rft.volume=91&rft.issue=2&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-016-1713-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Number of references - 62 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1007/s00204-016-1713-z ER - TY - JOUR T1 - Pioglitazone and bladder cancer: FDA's assessment AN - 1868321273; PQ0004093354 JF - Pharmacoepidemiology and Drug Safety AU - Hampp, Christian AU - Pippins, Jennifer AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 117 EP - 118 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 2 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868321273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Pioglitazone+and+bladder+cancer%3A+FDA%27s+assessment&rft.au=Hampp%2C+Christian%3BPippins%2C+Jennifer&rft.aulast=Hampp&rft.aufirst=Christian&rft.date=2017-02-01&rft.volume=26&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4154 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/pds.4154 ER - TY - JOUR T1 - A systematic review of pregnancy exposure registries: examination of protocol-specified pregnancy outcomes, target sample size, and comparator selection AN - 1868316088; PQ0004093353 AB - Purpose Our study sought to systematically evaluate protocol-specified study methodology in prospective pregnancy exposure registries including pre-specified pregnancy outcomes, power calculations for sample size, and comparator group selection. Methods U.S. pregnancy exposure registries designed to evaluate safety of drugs or biologics were identified from www.clinicaltrials.gov , the FDA's Office of Women's Health website, and the FDA's list of postmarketing studies. Protocols or similar documentation were obtained. Results We identified 35 U.S. registries for drugs or biologic use during pregnancy. All registries assessed risk for overall major congenital malformations. Pre-specified target enrollment was stated for 18 (51%) registries, and ranged from 150 to 500 exposed pregnancies (median 300). Thirty-two (91%) registries identified at least one comparison group, but only nine (26%) planned to use an internal comparator. The most common external comparator group (n=24, 69%) was the Metropolitan Atlanta Congenital Defects Program (MACDP). Conclusions No registries were designed to have sufficient power to assess specific malformations, despite the plausibility that most teratogens cause specific defects. Only half of the registries included a power analysis. Despite their common use, external comparators, including MACDP, have important limitations. In the absence of randomized controlled trial data in pregnant women, pregnancy registries remain an important tool as part of a comprehensive pregnancy surveillance program; however, pregnancy registries alone may not be sufficient to obtain adequate data regarding risks of specific malformations. JF - Pharmacoepidemiology and Drug Safety AU - Gelperin, Kate AU - Hammad, Hoda AU - Leishear, Kira AU - Bird, Steven T AU - Taylor, Lockwood AU - Hampp, Christian AU - Sahin, Leyla AD - U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER), Office of Surveillance and Epidemiology, Silver Spring, MD, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 208 EP - 214 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 2 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868316088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=A+systematic+review+of+pregnancy+exposure+registries%3A+examination+of+protocol-specified+pregnancy+outcomes%2C+target+sample+size%2C+and+comparator+selection&rft.au=Gelperin%2C+Kate%3BHammad%2C+Hoda%3BLeishear%2C+Kira%3BBird%2C+Steven+T%3BTaylor%2C+Lockwood%3BHampp%2C+Christian%3BSahin%2C+Leyla&rft.aulast=Gelperin&rft.aufirst=Kate&rft.date=2017-02-01&rft.volume=26&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4150 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/pds.4150 ER - TY - JOUR T1 - Drug availability adjustments in population-based studies of prescription opioid abuse AN - 1868310223; PQ0004093351 AB - Purpose Population-based prescription opioid abuse studies in which one drug is compared to another, or drugs are compared across time, often account for the availability of those drugs in the community. The objective of this investigation is to assess consistency in the relative abuse ratios (RARs) across different approaches for adjusting for drug availability. Methods For the years 2004 through 2010, RARs for each of four prescription opioids (hydrocodone, oxycodone, hydromorphone, and morphine) were calculated using negative binomial regression. Measures of abuse (outcome) were misuse/abuse-related emergency department visits obtained from the Drug Abuse Warning Network. Measures of drug availability (offsets) were drug utilization estimates obtained from IMS Health. Separate regression models were run using each of five measures of drug utilization: unique patients (URDD), prescriptions dispensed (RX), tablets dispensed (TD), kilograms (KGs) sold, and morphine-equivalents (MEs) of kilograms sold. These results were compared for consistency. Results Aside from oxycodone-combination products, across molecules, RARs adjusted by RXs, TDs, and URDDs were generally similar to each other while RARs adjusted by KGs and MEs were different. For example, compared to hydrocodone, oxycodone had statistically significantly increased RARs of 3.6 (95%CI: 2.0-6.5), 3.5 (95%CI: 1.9-6.4), and 2.7 (95%CI: 1.5-5.0) when adjusted by URDDs, RXs, and TDs, respectively, but not when adjusted by KGs or MEs. Conclusions Different drug utilization adjustment approaches may yield inconsistent RAR estimates in population-based prescription opioid abuse analyses. JF - Pharmacoepidemiology and Drug Safety AU - Secora, Alex AU - Trinidad, James Phillip AU - Zhang, Rongmei AU - Gill, Rajdeep AU - Dal Pan, Gerald AD - Office of Surveillance and Epidemiology, Division of Epidemiology, Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 180 EP - 191 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 2 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868310223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Drug+availability+adjustments+in+population-based+studies+of+prescription+opioid+abuse&rft.au=Secora%2C+Alex%3BTrinidad%2C+James+Phillip%3BZhang%2C+Rongmei%3BGill%2C+Rajdeep%3BDal+Pan%2C+Gerald&rft.aulast=Secora&rft.aufirst=Alex&rft.date=2017-02-01&rft.volume=26&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4139 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/pds.4139 ER - TY - JOUR T1 - Rapid Testing of Food Matrices for Bacillus cereus Enterotoxins AN - 1868306184; PQ0004035381 AB - Nine different food products frequently associated with Bacillus cereus outbreaks were chosen as representative matrices to be evaluated with end-point polymerase chain reaction (PCR), enzyme linked immunosorbent assay, lateral flow device and mass spectrometry for detection of enterotoxins associated with human illness. Testing was performed on food portions inoculated with a bacterial strain and incubated at 30 degree C for either 5 h or 24 h. A screening end-point multiplex PCR targeting enterotoxin genes including the emetic toxin and three diarrheal toxins, hemolytic hemolysin BL (Hbl), nonhemoltyic enterotoxin (Nhe), and cytolysin K. Commercially available kits were used to determine the presence/absence of Nhe and Hbl. Finally; a quantitative analysis using mass spectrometry was performed for the detection of the emetic toxin. Definitive results were available after a five hour pre-enrichment in five food products. The following strategy would allow for more efficient testing of surveillance or environmental samples as well as more rapid response time during a foodborne outbreak. Practical Applications The application of a strategy for processing and analyzing food products for Bacillus cereus and the enterotoxins associated with foodborne illness was explored. Employment of such a strategy will decrease time spent processing negative samples allowing more time for analysis of potentially positive food products. JF - Journal of Food Safety AU - Tallent, Sandra M AU - Hait, Jennifer M AU - Knolhoff, Ann M AU - Bennett, Reginald W AU - Hammack, Thomas S AU - Croley, Timothy R AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD, 20740. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - [np] PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 37 IS - 1 SN - 0149-6085, 0149-6085 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868306184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Effects+of+subchronic+exposure+of+silver+nanoparticles+on+intestinal+microbiota+and+gut-associated+immune+responses+in+the+ileum+of+Sprague-Dawley+rats&rft.au=Williams%2C+Katherine%3BMilner%2C+Jessica%3BBoudreau%2C+Mary+D%3BGokulan%2C+Kuppan%3BCerniglia%2C+Carl+E%3BKhare%2C+Sangeeta&rft.aulast=Williams&rft.aufirst=Katherine&rft.date=2015-05-01&rft.volume=9&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2014.921346 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1111/jfs.12292 ER - TY - JOUR T1 - Flow-Cytometry-Based Method to Detect Escherichia coli and Shigella Spp. Using 16S rRNA-Based Probe. AN - 1863711267; 28146281 AB - Detection of microbial contamination in foods before they go on to the market can help prevent the occurrence of foodborne illness outbreaks. Current methods for the detection of Escherichia coli are limited by time-consuming procedures, which include multiple culture incubation steps, and require several days to get results. This unit describes the development of an improved rapid flow-cytometry-based detection method that has greater sensitivity and specificity. This method requires less time-to-results (TTR) and can detect a small number of E. coli in the presence of large numbers of other bacteria. Clear step-by-step protocols for cell concentration determination, sample preparation, and flow cytometric analysis are provided. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc. JF - Current protocols in toxicology AU - Xue, Yong AU - Wilkes, Jon G AU - Moskal, Ted J AU - Williams, Anna J AU - Cooper, Willie M AU - Buzatu, Dan A AD - Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. ; Life Sciences Consultant, Jonesboro, Arkansas. Y1 - 2017/02/01/ PY - 2017 DA - 2017 Feb 01 SP - 2.25.1 EP - 2.25.8 VL - 71 KW - microbial contamination KW - oligonucleotide probe KW - Escherichia coli KW - Shigella KW - flow cytometry KW - Salmonella KW - foodborne illness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1863711267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+protocols+in+toxicology&rft.atitle=Flow-Cytometry-Based+Method+to+Detect+Escherichia+coli+and+Shigella+Spp.+Using+16S+rRNA-Based+Probe.&rft.au=Xue%2C+Yong%3BWilkes%2C+Jon+G%3BMoskal%2C+Ted+J%3BWilliams%2C+Anna+J%3BCooper%2C+Willie+M%3BBuzatu%2C+Dan+A&rft.aulast=Xue&rft.aufirst=Yong&rft.date=2017-02-01&rft.volume=71&rft.issue=&rft.spage=2.25.1&rft.isbn=&rft.btitle=&rft.title=Current+protocols+in+toxicology&rft.issn=1934-9262&rft_id=info:doi/10.1002%2Fcptx.14 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-02-01 N1 - Date revised - 2017-02-03 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1002/cptx.14 ER - TY - JOUR T1 - Whole genome sequencing of mouse lymphoma L5178Y-3.7.2C (TK+/-) reveals millions of mutations and genetic markers. AN - 1863217172; 28137362 AB - The mouse lymphoma L5178Y-3.7.2C (TK+/-) cell line is extensively used in genetic toxicology to conduct the mouse lymphoma assay (MLA). The MLA is used to establish the mutagenic and clastogenic effects of chemicals and pharmaceuticals, and is one of the few genetic tests widely accepted by regulatory agencies throughout the world. Despite the extensive use and regulatory impact of L5178Y-3.7.2C (TK+/-) cells, little is known about their genetic composition or how it affects the outcome of the MLA. To determine the genetic background of this cell line, we sequenced and analyzed its entire genome. Our results confirm the existence of previously described mutations in the Tk1 and Trp53 genes and catalog millions of other mutations, many of which impair the function of genes with key roles in cell physiology and genetic toxicology. Published by Elsevier B.V. JF - Mutation research AU - McKinzie, Page B AU - Revollo, Javier R AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Page.McKinzie@fda.hhs.gov. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Javier.Revollo@fda.hhs.gov. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 1 EP - 6 VL - 814 KW - Genetics KW - Next generation sequencing KW - SNPs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1863217172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Whole+genome+sequencing+of+mouse+lymphoma+L5178Y-3.7.2C+%28TK%2B%2F-%29+reveals+millions+of+mutations+and+genetic+markers.&rft.au=McKinzie%2C+Page+B%3BRevollo%2C+Javier+R&rft.aulast=McKinzie&rft.aufirst=Page&rft.date=2017-02-01&rft.volume=30&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgeu082 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-31 N1 - Date revised - 2017-02-02 N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1016/j.mrgentox.2016.12.001 ER - TY - JOUR T1 - The Epicenter of Effectiveness and Efficiency in Health Care Delivery: The Evolving U.S. Health Workforce AN - 1862137659 AB - In the decade between 2014 and 2024, the health care and social assistance sector is projected to add more jobs to the U.S. economy than any other industry (BLS, 2015). According to the Bureau of Labor Statistics, 19 of the 30 fastest growing occupations in the United States are in health care (BLS, 2016). The drivers of this demand in health care employment include an increased need for care by a rapidly aging population, expansion of insurance coverage under the Affordable Care Act (ACA), and subsector innovations, such as those in Health Information Technology and medical science. In addition to these factors, the push toward improved access to care and improved quality of care has put the health care workforce at the center of the system transformation “storm.” This environment has created a demand for an innovative and flexible health care workforce. However, there are very real concerns that the United States does not and will not have the workforce it needs to meet this demand without significant change. This sentiment stems from several current trends. First, there is the question of whether there will be enough providers in certain occupations and professions. Workforce projections for health care occupations vary in terms of predicted shortages and surpluses (HRSA, 2016). Second, there continues to be uneven geographic distribution for some occupations, including dentists (HRSA, 2015), primary care physicians (Petterson et al. 2013; AHRQ, 2014), and nurses (HRSA, 2014). Finally, how and what providers learn when they are trained for practice, with an eye toward improved delivery and quality of care, is still evolving. For example, there has been a movement toward teaching interprofessional, team-based care (Bridgeset al. 2011). JF - Health Services Research AU - Washko, Michelle M AU - Fennell, Mary L AD - National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD ; Department of Sociology, Department of Health Services Policy and Practice, Brown University, Providence, RI ; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 353 EP - 359 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - S1 SN - 0017-9124 KW - Medical Sciences KW - Labour force KW - Health care KW - Service delivery KW - Care delivery KW - Occupational health and safety KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862137659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=The+Epicenter+of+Effectiveness+and+Efficiency+in+Health+Care+Delivery%3A+The+Evolving+U.S.+Health+Workforce&rft.au=Washko%2C+Michelle+M%3BFennell%2C+Mary+L&rft.aulast=Washko&rft.aufirst=Michelle&rft.date=2017-02-01&rft.volume=52&rft.issue=S1&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12662 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-27 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1111/1475-6773.12662 ER - TY - JOUR T1 - Perspectives: Using Results from HRSA's Health Workforce Simulation Model to Examine the Geography of Primary Care AN - 1862137605 AB - Objective Inform health planning and policy discussions by describing Health Resources and Services Administration's (HRSA's) Health Workforce Simulation Model (HWSM) and examining the HWSM's 2025 supply and demand projections for primary care physicians, nurse practitioners (NPs), and physician assistants (PAs). Data Sources HRSA's recently published projections for primary care providers derive from an integrated microsimulation model that estimates health workforce supply and demand at national, regional, and state levels. Principal Findings Thirty-seven states are projected to have shortages of primary care physicians in 2025, and nine states are projected to have shortages of both primary care physicians and PAs. While no state is projected to have a 2025 shortage of primary care NPs, many states are expected to have only a small surplus. Conclusions Primary care physician shortages are projected for all parts of the United States, while primary care PA shortages are generally confined to Midwestern and Southern states. No state is projected to have shortages of all three provider types. Projected shortages must be considered in the context of baseline assumptions regarding current supply, demand, provider-service ratios, and other factors. Still, these findings suggest geographies with possible primary care workforce shortages in 2025 and offer opportunities for targeting efforts to enhance workforce flexibility. JF - Health Services Research AU - Streeter, Robin A AU - Zangaro, George A AU - Chattopadhyay, Arpita AD - National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD ; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 481 EP - 507 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - S1 SN - 0017-9124 KW - Medical Sciences KW - Doctors' assistants KW - Supply and demand KW - Labour force KW - Flexibility KW - Doctors KW - Simulation KW - Projections KW - Shortages KW - Geography KW - Health status KW - Primary health care KW - Nurse practitioners KW - Health professionals KW - Occupational health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862137605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Perspectives%3A+Using+Results+from+HRSA%27s+Health+Workforce+Simulation+Model+to+Examine+the+Geography+of+Primary+Care&rft.au=Streeter%2C+Robin+A%3BZangaro%2C+George+A%3BChattopadhyay%2C+Arpita&rft.aulast=Streeter&rft.aufirst=Robin&rft.date=2017-02-01&rft.volume=52&rft.issue=S1&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12663 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-27 DO - http://dx.doi.org/10.1111/1475-6773.12663 ER - TY - JOUR T1 - Veterans' Location in Health Professional Shortage Areas: Implications for Access to Care and Workforce Supply AN - 1862136670 AB - Objective To describe the distribution of Veterans in areas of the United States where there are potentially inadequate supplies of health professionals, and to explore opportunities suggested by this distribution for fostering health workforce flexibility. Data Sources County-level data from the 2015-2016 Health Resources and Services Administration's (HRSA's) Area Health Resources Files (AHRF) were used to estimate Veteran populations in HRSA-designated health professional shortage areas (HPSAs). This information was then linked to 2015 VA health facility information from the Department of Veterans Affairs. Study Design Potential Veteran populations living in Shortage Area Counties with no VHA facilities were estimated, and the composition of these populations was explored by Census division and state. Principal Findings Nationwide, approximately 24 percent of all Veterans and 23 percent of Veterans enrolled in VHA health care live in Shortage Area Counties. These estimates mask considerable variation across states. Conclusions An examination of Veterans residing in Shortage Area Counties suggests extensive maldistribution of health services across the United States and the continued need to find ways to improve health care access for all Veterans. Effective avenues for doing so may include increasing health workforce flexibility through expansion of nurse practitioner scopes of practice. JF - Health Services Research AU - Doyle, Jamie Mihoko AU - Streeter, Robin A AD - Office of Extramural Research, Office of the Director, National Institutes of Health, Bethesda, MD; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD ; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD ; Office of Extramural Research, Office of the Director, National Institutes of Health, Bethesda, MD; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 459 EP - 480 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - S1 SN - 0017-9124 KW - Medical Sciences KW - Veterans KW - Labour force KW - Composition KW - Service provision KW - Flexibility KW - Census KW - Health services KW - Occupational health and safety KW - Health professionals KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862136670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Veterans%27+Location+in+Health+Professional+Shortage+Areas%3A+Implications+for+Access+to+Care+and+Workforce+Supply&rft.au=Doyle%2C+Jamie+Mihoko%3BStreeter%2C+Robin+A&rft.aulast=Doyle&rft.aufirst=Jamie&rft.date=2017-02-01&rft.volume=52&rft.issue=S1&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12633 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-27 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1111/1475-6773.12633 ER - TY - JOUR T1 - Clarifying the Predictive Value of Family-Centered Care and Shared Decision Making for Pediatric Healthcare Outcomes Using the Medical Expenditure Panel Survey AN - 1861335445 AB - Objectives To estimate (1) family-centered care (FCC) and shared decision-making (SDM) prevalence, and (2) associations of FCC and SDM (FCC/SDM) with health care outcomes among U.S. children. Data Source The Medical Expenditure Panel Survey Household Component (MEPS-HC), a nationally representative survey of the noninstitutionalized, civilian population. Study Design Secondary analyses of prospectively collected data on 15,764 U.S. children were conducted to examine FCC/SDM prevalence in year 1 and associations of FCC/SDM in year 1 with health services utilization, medical expenditures, and unmet health care needs in year 2. Data Collection/Extraction Methods We combined four MEPS-HC longitudinal files from 2007 to 2011. Principal Findings FCC/SDM prevalence in year 1 varied from 38.6 to 93.7 percent, and it was lower for composites with more stringent scoring approaches. FCC/SDM composites with stringent scoring approaches in year 1 were associated with reduced unmet needs in year 2. FCC/SDM, across all year 1 composites, was not associated with health services utilization or medical expenditures in year 2. FCC/SDM year 1 subcomponents describing consensus building and mutual agreement were consistently associated with unmet health care needs in year 2. Conclusions FCC/SDM composites with stringent scoring approaches measuring consensus building and mutual agreement may have the greatest utility for pediatric health care quality improvement efforts. JF - Health Services Research AU - Lindly, Olivia J AU - Zuckerman, Katharine E AU - Mistry, Kamila B AD - School of Social and Behavioral Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR; Division of General Pediatrics, Oregon Health & Science University, Portland, OR ; Division of General Pediatrics, Oregon Health & Science University, Portland, OR ; Agency for Healthcare Research and Quality, Office of Extramural Research, Education, and Priority Populations, Rockville, MD ; School of Social and Behavioral Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR; Division of General Pediatrics, Oregon Health & Science University, Portland, OR Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 313 EP - 345 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - 1 SN - 0017-9124 KW - Medical Sciences KW - Quality management KW - Clinical outcomes KW - Extraction KW - Consensus building KW - Decision making KW - Family centred care KW - Health status KW - Collaborative decision making KW - Surveys KW - Helpseeking KW - Quality of care KW - Approaches KW - Unmet needs KW - Health services KW - Health costs KW - Expenditure KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861335445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Clarifying+the+Predictive+Value+of+Family-Centered+Care+and+Shared+Decision+Making+for+Pediatric+Healthcare+Outcomes+Using+the+Medical+Expenditure+Panel%26amp%3B%23xa0%3BSurvey&rft.au=Lindly%2C+Olivia+J%3BZuckerman%2C+Katharine+E%3BMistry%2C+Kamila+B&rft.aulast=Lindly&rft.aufirst=Olivia&rft.date=2017-02-01&rft.volume=52&rft.issue=1&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12488 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Federal Communications Commission--FCC N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-25 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1111/1475-6773.12488 ER - TY - JOUR T1 - Physician and Practice-Level Drivers and Disparities around Meaningful Use Progress AN - 1861335428 AB - Objective To identify physician and practice characteristics that are markers of success for meaningful use of electronic health records (EHRs). Data Sources American Medical Association survey, Centers for Medicare & Medicaid Services' (CMS) EHR Incentive, Pioneer Accountable Care Organization, and PECOS Programs, the Office of the National Coordinator for Health IT's Regional Extension Center Program, and National Committee for Quality Assurance Patient-centered Medical Home certification program. Study Design Retrospective analysis of 865,370 physicians' participation in CMS's EHR Incentive Program and progress to stage 1 Meaningful Use between 2011 and 2013. Physician specialty, age, practice size, geographic markers, delivery reform participation, and technical assistance receipt were predictive elements. Principal Findings Medicaid physicians were progressing more slowly to Meaningful Use than Medicare physicians: by 2013, 8 in 10 physicians registered with Medicare had achieved meaningful use, compared to one-third of Medicaid-registered physicians. The strongest predictors of meaningful use were technical assistance (79 percent more likely) and delivery reform participation (34 percent more likely). Conclusions Continued outreach and technical assistance that demonstrates strong interactions between meaningful use of health IT and delivery reform may facilitate further adoption of both initiatives. JF - Health Services Research AU - Heisey-Grove, Dawn AU - King, Jennifer A AD - U.S. Department of Health and Human Services, Office of the National Coordinator for Health IT, Washington, DC ; Aledade, Inc., Bethesda, MD ; U.S. Department of Health and Human Services, Office of the National Coordinator for Health IT, Washington, DC Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 244 EP - 267 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - 1 SN - 0017-9124 KW - Medical Sciences KW - Participation KW - Doctors KW - Health inequalities KW - Patient centredness KW - Certification KW - Technical assistance KW - Assistance KW - Quality assurance KW - Medicare KW - Computerized medical records KW - Outreach programmes KW - Medicaid KW - Health records KW - Health initiatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861335428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Physician+and+Practice-Level+Drivers+and+Disparities+around+Meaningful+Use+Progress&rft.au=Heisey-Grove%2C+Dawn%3BKing%2C+Jennifer+A&rft.aulast=Heisey-Grove&rft.aufirst=Dawn&rft.date=2017-02-01&rft.volume=52&rft.issue=1&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12481 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1111/1475-6773.12481 ER - TY - JOUR T1 - Understanding Racial and Ethnic Disparities in Postsurgical Complications Occurring in U.S. Hospitals AN - 1861335279 AB - Objective To examine the role of patient, hospital, and community characteristics on racial and ethnic disparities in in-hospital postsurgical complications. Data Sources Healthcare Cost and Utilization Project, 2011 State Inpatient Databases; American Hospital Association Annual Survey of Hospitals; Area Health Resources Files; Centers for Medicare & Medicaid Services Hospital Compare database. Methods Nonlinear hierarchical modeling was conducted to examine the odds of patients experiencing any in-hospital postsurgical complication, as defined by Agency for Healthcare Research and Quality Patient Safety Indicators. Principal Findings A total of 5,474,067 inpatient surgical discharges were assessed using multivariable logistic regression. Clinical risk, payer coverage, and community-level characteristics (especially income) completely attenuated the effect of race on the odds of postsurgical complications. Patients without private insurance were 30 to 50 percent more likely to have a complication; patients from low-income communities were nearly 12 percent more likely to experience a complication. Private, not-for-profit hospitals in small metropolitan or micropolitan areas and higher nurse-to-patient ratios led to fewer postsurgical complications. Conclusions Race does not appear to be an important determinant of in-hospital postsurgical complications, but insurance and community characteristics have an effect. A population-based approach that includes improving the socioeconomic context may help reduce disparities in these outcomes. JF - Health Services Research AU - Witt, Whitney P AU - Coffey, Rosanna M AU - Lopez-Gonzalez, Lorena AU - Barrett, Marguerite L AU - Moore, Brian J AU - Andrews, Roxanne M AU - Washington, Raynard E AD - Maternal and Child Health Research, Truven Health Analytics, Inc., Durham, NC ; Federal Government, Truven Health Analytics, Inc., Bethesda, MD ; Life Sciences, Truven Health Analytics, Inc., Austin, TX ; ML Barrett INC, San Diego, CA ; Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Rockville, MD ; Department of Health and Human Services, Agency for Healthcare Research and Quality, Rockville, MD ; Maternal and Child Health Research, Truven Health Analytics, Inc., Durham, NC Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 220 EP - 243 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - 1 SN - 0017-9124 KW - Medical Sciences KW - Safety measures KW - Databases KW - Ethnic differences KW - Health inequalities KW - Private hospitals KW - Nonprofit making organizations KW - Insurance KW - Race KW - Medicare KW - Racial inequalities KW - Health insurance KW - Nonlinear KW - Medical research KW - Coverage KW - Medicaid KW - Hospitalization KW - Low income people KW - Communities KW - Complications KW - Characteristics KW - Private sector KW - Patient care KW - Socioeconomic factors KW - Health costs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861335279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Understanding+Racial+and+Ethnic+Disparities+in+Postsurgical+Complications+Occurring+in+U.S.+Hospitals&rft.au=Witt%2C+Whitney+P%3BCoffey%2C+Rosanna+M%3BLopez-Gonzalez%2C+Lorena%3BBarrett%2C+Marguerite+L%3BMoore%2C+Brian+J%3BAndrews%2C+Roxanne+M%3BWashington%2C+Raynard+E&rft.aulast=Witt&rft.aufirst=Whitney&rft.date=2017-02-01&rft.volume=52&rft.issue=1&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12475 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1111/1475-6773.12475 ER - TY - JOUR T1 - Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Research Recommendations. AN - 1859715278; 27517672 AB - BACKGROUND The current single-chemical-as-carcinogen risk assessment paradigm might underestimate or miss the cumulative effects of exposure to chemical mixtures, as highlighted in recent work from the Halifax Project. This is particularly important for chemical exposures in the low-dose range that may be affecting crucial cancer hallmark mechanisms that serve to enable carcinogenesis. OBJECTIVE Could ongoing low-dose exposures to a mixture of commonly encountered environmental chemicals produce effects in concert that lead to carcinogenesis? A workshop held at the NIEHS in August 2015 evaluated the scientific support for the low-dose mixture hypothesis of carcinogenesis and developed a research agenda. Here we describe the science that supports this novel theory, identify knowledge gaps, recommend future methodologies, and explore preventative risk assessment and policy decision-making that incorporates cancer biology, environmental health science, translational toxicology, and clinical epidemiology. DISCUSSION AND CONCLUSIONS The theoretical merits of the low-dose carcinogenesis hypothesis are well founded with clear biological relevance, and therefore, the premise warrants further investigation. Expert recommendations include the need for better insights into the ways in which noncarcinogenic constituents might combine to uniquely affect the process of cellular transformation (in vitro) and environmental carcinogenesis (in vivo), including investigations of the role of key defense mechanisms in maintaining transformed cells in a dormant state. The scientific community will need to acknowledge limitations of animal-based models in predicting human responses; evaluate biological events leading to carcinogenesis both spatially and temporally; examine the overlap between measurable cancer hallmarks and characteristics of carcinogens; incorporate epigenetic biomarkers, in silico modelling, high-performance computing and high-resolution imaging, microbiome, metabolomics, and transcriptomics into future research efforts; and build molecular annotations of network perturbations. The restructuring of many existing regulatory frameworks will require adequate testing of relevant environmental mixtures to build a critical mass of evidence on which to base policy decisions. Citation: Miller MF, Goodson WH III, Manjili MH, Kleinstreuer N, Bisson WH, Lowe L. 2017. Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: scientific underpinnings and research recommendations. Environ Health Perspect 125:163-169; http://dx.doi.org/10.1289/EHP411. JF - Environmental health perspectives AU - Miller, Mark F AU - Goodson, William H AU - Manjili, Masoud H AU - Kleinstreuer, Nicole AU - Bisson, William H AU - Lowe, Leroy AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 163 EP - 169 VL - 125 IS - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859715278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Low-Dose+Mixture+Hypothesis+of+Carcinogenesis+Workshop%3A+Scientific+Underpinnings+and+Research+Recommendations.&rft.au=Miller%2C+Mark+F%3BGoodson%2C+William+H%3BManjili%2C+Masoud+H%3BKleinstreuer%2C+Nicole%3BBisson%2C+William+H%3BLowe%2C+Leroy&rft.aulast=Pan&rft.aufirst=Hongmiao&rft.date=2015-05-01&rft.volume=42&rft.issue=5&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.issn=13675435&rft_id=info:doi/10.1007%2Fs10295-015-1599-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-02-08 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1289/EHP411 ER - TY - JOUR T1 - Simultaneous Analysis of 3-MCPD and 1,3-DCP in Asian Style Sauces Using QuEChERS Extraction and Gas Chromatography-Triple Quadrupole Mass Spectrometry. AN - 1856866657; 28064506 AB - Acid hydrolyzed vegetable protein (aHVP) is used for flavoring a wide variety of foods and also in the production of nonfermented soy sauce. During the production of aHVP, chloropropanols including 3-monochloropropane-1,2-diol (3-MCPD) and 1,3 dichloropropane-2-ol (1,3-DCP) can be formed through the reaction of the hydrochloric acid catalyst and residual fat and the reaction of 3-MCPD with acetic acid, respectively. 3-MCPD is a carcinogen, and 1,3-DCP has been classified as a genotoxic carcinogen. The European Union (EU) has set a maximum concentration of 0.02 mg/kg of 3-MCPD in aHVP, and the Food and Drug Administration (FDA) set a guidance limit of 1 mg/kg of 3-MCPD in aHVP. 1,3-DCP is not an approved food additive, and the Joint FAO/WHO Expert Committee on Food Additives (JEFCA) has set a limit at 0.005 mg/kg, which is close to the estimated method detection limit. Currently there are few analytical methods for the simultaneous determination of 3-MCPD and 1,3-DCP without derivatization due to differences in their physical chemical properties and reactivity. A new method was developed using QuEChERS (quick, easy, cheap, effective, rugged, and safe) with direct analysis of the extract without derivatization using gas chromatography-triple quadrupole mass spectrometry (GC-QQQ). Additionally, a market sampling of 60 soy sauce samples was performed in 2015 to determine if concentrations have changed since the FDA limit was set in 2008. The sampling results were compared between the new QuEChERS method and a method using phenylboronic acid (PBA) as a derivatizing agent for 3-MCPD analysis. The concentrations of 3-MCPD detected in soy sauce samples collected in 2015 (19000 genes across organs, ages, and sexes ranged from 2.35 to >109-fold, with a median of 165-fold. The expression of 278 SEGs was found to vary ≤4-fold and these genes were significantly involved in protein catabolism (proteasome and ubiquitination), RNA transport, protein processing, and the spliceosome. Such stability of expression was further validated in human samples where the expression variability of the homologous human SEGs was significantly lower than that of other genes in the human genome. It was also found that the homologous human SEGs were generally less subject to non-synonymous mutation than other genes, as would be expected of stably expressed genes. We also found that knockout of SEG homologs in mouse models was more likely to cause complete preweaning lethality than non-SEG homologs, corroborating the fundamental roles played by SEGs in biological development. Such stably expressed genes and pathways across life-stages suggest that tight control of these processes is important in basic cellular functions and that perturbation by endogenous (e.g., genetics) or exogenous agents (e.g., drugs, environmental factors) may cause serious adverse effects. JF - PloS one AU - Wang, Kejian AU - Vijay, Vikrant AU - Fuscoe, James C AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America. Y1 - 2017 PY - 2017 DA - 2017 SP - 1 VL - 12 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1865555466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Tuberculosis+Control+in+South+African+Gold+Mines%3A+Mathematical+Modeling+of+a+Trial+of+Community-Wide+Isoniazid+Preventive+Therapy&rft.au=Vynnycky%2C+Emilia%3BSumner%2C+Tom%3BFielding%2C+Katherine+L%3BLewis%2C+James+J%3BCox%2C+Andrew+P%3BHayes%2C+Richard+J%3BCorbett%2C+Elizabeth+L%3BChurchyard%2C+Gavin+J%3BGrant%2C+Alison+D%3BWhite%2C+Richard+G&rft.aulast=Vynnycky&rft.aufirst=Emilia&rft.date=2015-04-15&rft.volume=181&rft.issue=8&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwu320 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-26 N1 - Date revised - 2017-02-07 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1371/journal.pone.0170813 ER - TY - JOUR T1 - Reasons for Not Seeking Substance Use Disorder Treatment: Variations by Health Insurance Coverage AN - 1865315478 AB - A large number of adults with substance use disorder (SUD) do not receive treatment for their condition. Using data from the 2008-2013 National Survey of Drug Use and Health (NSDUH), this study analyzes why individuals with SUD report not receiving treatment even when they perceived a need for it. It further examines the variations in reported reasons for not receiving treatment by health insurance status and type. The results suggest that barriers such as stigma, lack of readiness to stop using substances, and not making treatment a priority are more common among the insured population, especially among those with private insurance. Financial barriers, such as not being able to afford the cost of treatment, are more prominent among the uninsured population. Efforts to improve utilization of treatment services will need to address financial as well as barriers related to stigma. JF - Journal of Behavioral Health Services & Research AU - Ali, Mir M, PhD AU - Teich, Judith L, MSW AU - Mutter, Ryan, PhD AD - Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA ; Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA Y1 - 2017/01// PY - 2017 DA - Jan 2017 SP - 63 EP - 74 CY - Gaithersburg PB - Springer Science & Business Media VL - 44 IS - 1 SN - 1094-3412 KW - Public Health And Safety KW - Treatment needs KW - Substance abuse disorders KW - Barriers KW - Treatment KW - Readiness KW - Stigmatization KW - Insurance KW - Health status KW - Health insurance KW - Coverage KW - Helpseeking KW - National surveys KW - Uninsured patients KW - Drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1865315478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Reasons+for+Not+Seeking+Substance+Use+Disorder+Treatment%3A+Variations+by+Health+Insurance+Coverage&rft.au=Ali%2C+Mir+M%2C+PhD%3BTeich%2C+Judith+L%2C+MSW%3BMutter%2C+Ryan%2C+PhD&rft.aulast=Ali&rft.aufirst=Mir&rft.date=2017-01-01&rft.volume=44&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-016-9538-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - The Journal of Behavioral Health Services & Research is a copyright of Springer, 2017. N1 - Last updated - 2017-02-06 DO - http://dx.doi.org/10.1007/s11414-016-9538-3 ER - TY - JOUR T1 - Assessing Sex Differences in the Risk of Cardiovascular Disease and Mortality per Increment in Systolic Blood Pressure: A Systematic Review and Meta-Analysis of Follow-Up Studies in the United States. AN - 1862285127; 28122035 AB - In the United States (US), cardiovascular (CV) disease accounts for nearly 20% of national health care expenses. Since costs are expected to increase with the aging population, informative research is necessary to address the growing burden of CV disease and sex-related differences in diagnosis, treatment, and outcomes. Hypertension is a major risk factor for CV disease and mortality. To evaluate whether there are sex-related differences in the effect of systolic blood pressure (SBP) on the risk of CV disease and mortality, we performed a systematic review and meta-analysis. We conducted a comprehensive search using PubMed and Google Scholar to identify US-based studies published prior to 31 December, 2015. We identified eight publications for CV disease risk, which provided 9 female and 8 male effect size (ES) observations. We also identified twelve publications for CV mortality, which provided 10 female and 18 male ES estimates. Our meta-analysis estimated that the pooled ES for increased risk of CV disease per 10 mmHg increment in SBP was 25% for women (95% Confidence Interval (CI): 1.18, 1.32) and 15% for men (95% CI: 1.11, 1.19). The pooled increase in CV mortality per 10 mm Hg SBP increment was similar for both women and men (Women: 1.16; 95% CI: 1.10, 1.23; Men: 1.17; 95% CI: 1.12, 1.22). After adjusting for age and baseline SBP, the results demonstrated that the risk of CV disease per 10 mm Hg SBP increment for women was 1.1-fold higher than men (P<0.01; 95% CI: 1.04, 1.17). Heterogeneity was moderate but significant. There was no significant sex difference in CV mortality. JF - PloS one AU - Wei, Yu-Chung AU - George, Nysia I AU - Chang, Ching-Wei AU - Hicks, Karen A AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America. ; Office of Drug Evaluation I, Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, United States of America. Y1 - 2017 PY - 2017 DA - 2017 SP - 1 VL - 12 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862285127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Assessing+Sex+Differences+in+the+Risk+of+Cardiovascular+Disease+and+Mortality+per+Increment+in+Systolic+Blood+Pressure%3A+A+Systematic+Review+and+Meta-Analysis+of+Follow-Up+Studies+in+the+United+States.&rft.au=Wei%2C+Yu-Chung%3BGeorge%2C+Nysia+I%3BChang%2C+Ching-Wei%3BHicks%2C+Karen+A&rft.aulast=Wei&rft.aufirst=Yu-Chung&rft.date=2017-01-01&rft.volume=12&rft.issue=1&rft.spage=e0170218&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0170218 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-25 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1371/journal.pone.0170218 ER - TY - JOUR T1 - New Composites LnBDC@AC and CB[6]@AC: From Design toward Selective Adsorption of Methylene Blue or Methyl Orange AN - 1860295780 AB - New porous composites LnBDC@AC (AC = Activated carbon, Ln = Eu and Gd and BDC = 1,4-benzenedicaboxylate) and CB[6]@AC (CB[6] = Cucurbit[6]uril) were obtained using hydrothermal route. The LnBDC and CB[B] are located inside the pore of the carbon materials as was observed in SEM-EDS, XRPD and FT-IR analysis. Porosimetry analysis showed values typically between AC and LnBDC material, with pore size and surface area, respectively, 29,56 Å and 353.98 m2g-1 for LnBDC@AC and 35,53 Å and 353.98 m2g-1 for CB[6]@AC. Both materials showed good absorptive capacity of metil orange (MO) and methylene blue (MB) with selectivity as a function of pH. For acid pH, both materials present selectivity by MB and alkaline pH for MO, with notable performance for CB[6]@AC. Additionally, europium luminescence was used as structural probe to investigate the coordination environment of Eu3+ ions in the EuBDC@AC composite after adsorption experiment. JF - PLoS One AU - Santos, Guilherme deC AU - Barros, Amanda L AU - Oliveira, A Fde AU - Luz, Leonis Lda AU - Silva, Fausthon Fda AU - Demets, Grégoire J-F AU - Júnior, Severino Alves Y1 - 2017/01// PY - 2017 DA - Jan 2017 CY - San Francisco PB - Public Library of Science VL - 12 IS - 1 KW - Sciences: Comprehensive Works KW - Dyes KW - Adsorption KW - Spectrum analysis KW - Activated carbon KW - Aqueous solutions KW - Stainless steel KW - Ligands KW - Photovoltaic cells KW - Porous materials KW - Charcoal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1860295780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=New+Composites+LnBDC%40AC+and+CB%5B6%5D%40AC%3A+From+Design+toward+Selective+Adsorption+of+Methylene+Blue+or+Methyl+Orange&rft.au=Santos%2C+Guilherme+deC%3BBarros%2C+Amanda+L%3BOliveira%2C+A+Fde%3BLuz%2C+Leonis+Lda%3BSilva%2C+Fausthon+Fda%3BDemets%2C+Gr%C3%A9goire+J-F%3BJ%C3%BAnior%2C+Severino+Alves&rft.aulast=Santos&rft.aufirst=Guilherme&rft.date=2017-01-01&rft.volume=12&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pone.0170026 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - © 2017 Santos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Santos GdC, Barros AL, de Oliveira CAF, da Luz LL, da Silva FF, Demets GJ-F, et al. (2017) New Composites LnBDC@AC and CB[6]@AC: From Design toward Selective Adsorption of Methylene Blue or Methyl Orange. PLoS ONE 12(1): e0170026. doi:10.1371/journal.pone.0170026 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1371/journal.pone.0170026 ER - TY - JOUR T1 - Trimmed means for symptom trials with dropouts. AN - 1859716096; 27523396 AB - Dropouts from randomized trials, often for lack of efficacy or toxicity, have usually been handled as 'missing data'. We suggest that they are instead complete observations, just not numeric ones. We propose an exact test of the hypothesis of no drug effect, taking all randomized patients into account, based on a readily interpretable statistic. The method also copes with a drug that is toxic in some patients but beneficial to others, a difficult problem for standard methods. A robust conclusion of efficacy can be drawn with no assumptions other than randomization. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Pharmaceutical statistics AU - Permutt, Thomas AU - Li, Feng AD - Division of Biometrics II, Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, U.S.A. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 20 EP - 28 VL - 16 IS - 1 KW - robust KW - missing data KW - dropout KW - trimmed mean UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859716096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+statistics&rft.atitle=Trimmed+means+for+symptom+trials+with+dropouts.&rft.au=Permutt%2C+Thomas%3BLi%2C+Feng&rft.aulast=Permutt&rft.aufirst=Thomas&rft.date=2017-01-01&rft.volume=16&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+statistics&rft.issn=1539-1612&rft_id=info:doi/10.1002%2Fpst.1768 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-15 N1 - Date revised - 2017-01-30 N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1002/pst.1768 ER - TY - JOUR T1 - Comparative analysis of INLIGHT(TM)-labeled enzymatically depolymerized heparin by reverse-phase chromatography and high-performance mass spectrometry AN - 1859500312; PQ0004000489 AB - Structural characterization of the microheterogeneity of heparin, heparan sulfate, and other glycosaminoglycans is a major analytical challenge. We present the use of a stable isotope-labeled hydrazide tag (INLIGHT(TM)) with high-resolution/accurate mass (HRAM) reverse-phase LC-MS/MS, which was recently introduced for detailed study of N-glycan heterogeneity, to characterize heparinase-digested heparin (digHep) products without the use of semi-volatile ion pairing reagents. Using both full scan LC-MS and data-dependent LC-MS/MS, we identified 116 unique digHep species, a feat possible because of INLIGHT(TM) labeling. Of these, 83 digHep products were structurally identified, including the 12 standard disaccharides as well as 34 tetra- (DP4), 26 hexa- (DP6), 21 octa- (DP8), and 2 decasaccharides (DP10). Each of the 116 digHep species co-eluted with both light and heavy INLIGHT(TM) tags (L/H sub(avg)=1.039 plus or minus 0.163); thus enhancing confidence in their identification via MS and MS/MS. This work sets the foundation for INLIGHT(TM)-based comparative analyses of different forms of heparin, heparan sulfate, and other GAGs with high quantitative precision using mainstay reverse-phase HRAM LC-MS/MS. [Figure not available: see fulltext.] JF - Analytical and Bioanalytical Chemistry AU - Mangrum, John B AU - Mehta, Akul Y AU - Alabbas, Alhumaidi B AU - Desai, Umesh R AU - Hawkridge, Adam M AD - Food and Drug Administration, College Park, MD, 20740-3835, USA, amhawkridge@vcu.edu Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 499 EP - 509 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 409 IS - 2 SN - 1618-2642, 1618-2642 KW - Biotechnology and Bioengineering Abstracts KW - Glycosaminoglycans KW - Chromatography KW - N-glycans KW - Microheterogeneity KW - Heparin KW - Heparan sulfate KW - Mass spectroscopy KW - Disaccharides KW - Light effects KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859500312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Comparative+analysis+of+INLIGHT%28TM%29-labeled+enzymatically+depolymerized+heparin+by+reverse-phase+chromatography+and+high-performance+mass+spectrometry&rft.au=Mangrum%2C+John+B%3BMehta%2C+Akul+Y%3BAlabbas%2C+Alhumaidi+B%3BDesai%2C+Umesh+R%3BHawkridge%2C+Adam+M&rft.aulast=Mangrum&rft.aufirst=John&rft.date=2017-01-01&rft.volume=409&rft.issue=2&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-016-0055-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 53 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Glycosaminoglycans; Chromatography; N-glycans; Microheterogeneity; Heparan sulfate; Heparin; Mass spectroscopy; Light effects; Disaccharides DO - http://dx.doi.org/10.1007/s00216-016-0055-2 ER - TY - JOUR T1 - Bacteria in a water-damaged building: associations of actinomycetes and non-tuberculous mycobacteria with respiratory health in occupants AN - 1859485901; PQ0003987188 AB - We examined microbial correlates of health outcomes in building occupants with a sarcoidosis cluster and excess asthma. We offered employees a questionnaire and pulmonary function testing and collected floor dust and liquid/sludge from drain tubing traps of heat pumps that were analyzed for various microbial agents. Forty-nine percent of participants reported any symptom reflecting possible granulomatous disease (shortness of breath on exertion, flu-like achiness, or fever and chills) weekly in the last 4 weeks. In multivariate regressions, thermophilic actinomycetes (median = 529 CFU/m super(2)) in dust were associated with FEV sub(1)/FVC [coefficient = -2.8 per interquartile range change, P = 0.02], percent predicted FEF sub(25-75%) (coefficient = -12.9, P = 0.01), and any granulomatous disease-like symptom [odds ratio (OR) = 3.1, 95% confidence interval (CI) = 1.456.73]. Mycobacteria (median = 658 CFU/m super(2)) were positively associated with asthma symptoms (OR = 1.5, 95% CI = 0.972.43). Composite score (median = 11.5) of total bacteria from heat pumps was negatively associated with asthma (0.8, 0.711.00) and positively associated with FEV sub(1)/FVC (coefficient = 0.44, P = 0.095). Endotoxin (median score = 12.0) was negatively associated with two or more granulomatous disease-like symptoms (OR = 0.8, 95% CI = 0.670.98) and asthma (0.8, 0.670.96). Fungi or (1 arrow right 3)- beta -D-glucan in dust or heat pump traps was not associated with any health outcomes. Thermophilic actinomycetes and non-tuberculous mycobacteria may have played a role in the occupants' respiratory outcomes in this water-damaged building. JF - Indoor Air AU - Park, J-H AU - Cox-Ganser, J M AU - White, S K AU - Laney, A S AU - Caulfield, S M AU - Turner, WA AU - Sumner, AD AU - Kreiss, K AD - Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 24 EP - 33 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 27 IS - 1 SN - 0905-6947, 0905-6947 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Endotoxins KW - Sludges KW - Thermophilic bacteria KW - Respiratory diseases KW - Dust KW - Fever KW - Heat exchangers KW - Drains KW - Respiratory function KW - Actinomycetes KW - Bacteria KW - Composite materials KW - Inventories KW - Fungi KW - Asthma KW - Sarcoidosis KW - Sludge KW - Buildings KW - Lung KW - Heat KW - Colony-forming cells KW - Traps KW - Indoor environments KW - A 01340:Antibiotics & Antimicrobials KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859485901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Bacteria+in+a+water-damaged+building%3A+associations+of+actinomycetes+and+non-tuberculous+mycobacteria+with+respiratory+health+in+occupants&rft.au=Park%2C+J-H%3BCox-Ganser%2C+J+M%3BWhite%2C+S+K%3BLaney%2C+A+S%3BCaulfield%2C+S+M%3BTurner%2C+WA%3BSumner%2C+AD%3BKreiss%2C+K&rft.aulast=Park&rft.aufirst=J-H&rft.date=2017-01-01&rft.volume=27&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fina.12278 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Endotoxins; Inventories; Sludges; Fungi; Thermophilic bacteria; Asthma; Sarcoidosis; Dust; Fever; Heat; Lung; Colony-forming cells; Traps; Drains; Actinomycetes; Composite materials; Bacteria; Heat exchangers; Respiratory function; Respiratory diseases; Indoor environments; Sludge; Buildings DO - http://dx.doi.org/10.1111/ina.12278 ER - TY - JOUR T1 - Nonstandard work arrangements and worker health and safety AN - 1855077409; PQ0003960549 AB - Arrangements between those who perform work and those who provide jobs come in many different forms. Standard work arrangements now exist alongside several nonstandard arrangements: agency work, contract work, and gig work. While standard work arrangements are still the most prevalent types, the rise of nonstandard work arrangements, especially temporary agency, contract, and "gig" arrangements, and the potential effects of these new arrangements on worker health and safety have captured the attention of government, business, labor, and academia. This article describes the major work arrangements in use today, profiles the nonstandard workforce, discusses several legal questions about how established principles of labor and employment law apply to nonstandard work arrangements, summarizes findings published in the past 20 years about the health and safety risks for workers in nonstandard work arrangements, and outlines current research efforts in the area of healthy work design and worker well-being. Am. J. Ind. Med. 60:1-10, 2017. JF - American Journal of Industrial Medicine AU - Howard, John AD - National Institute for Occupational Safety and Health, Washington, DC. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1 EP - 10 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 1 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Safety engineering KW - Contracts KW - Safety KW - Occupational safety KW - Employment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855077409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Persistence+of+furan-induced+epigenetic+aberrations+in+the+livers+of+F344+rats.&rft.au=de+Conti%2C+Aline%3BKobets%2C+Tetyana%3BTryndyak%2C+Volodymyr%3BBurnett%2C+Sarah+D%3BHan%2C+Tao%3BFuscoe%2C+James+C%3BBeland%2C+Frederick+A%3BDoerge%2C+Daniel+R%3BPogribny%2C+Igor+P&rft.aulast=de+Conti&rft.aufirst=Aline&rft.date=2015-04-01&rft.volume=144&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu313 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Contracts; Safety engineering; Occupational safety; Safety; Employment DO - http://dx.doi.org/10.1002/ajim.22669 ER - TY - JOUR T1 - Method for analyzing left-censored bioassay data in large cohort studies AN - 1855073749; PQ0003964141 AB - In retrospective epidemiological studies of large cohorts of workers exposed to radioactive materials, it is often necessary to analyze large numbers of bioassay data sets containing censored values, or values recorded as less than a detection limit. Censored bioassay data create problems for all bioassay analysis methods, including analytical techniques based on least-squares regression to estimate intakes. A method is presented here that uses a simple empirically-derived equation for imputing replacement values for urine uranium concentration results reported as zero or less than a detection limit, that produces minimal bias in intakes estimated using least-square regression methods with the assumption of lognormally distributed measurement errors. JF - Journal of Exposure Science and Environmental Epidemiology AU - Anderson, Jeri L AU - Apostoaei, A Iulian AD - Division of Surveillance, Hazard Evaluations and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1 EP - 6 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 27 IS - 1 SN - 1559-0631, 1559-0631 KW - Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Bioassays KW - Mathematical models KW - Urine KW - Uranium KW - Radioactive materials KW - Occupational exposure KW - X 24390:Radioactive Materials KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855073749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Method+for+analyzing+left-censored+bioassay+data+in+large+cohort+studies&rft.au=Anderson%2C+Jeri+L%3BApostoaei%2C+A+Iulian&rft.aulast=Anderson&rft.aufirst=Jeri&rft.date=2017-01-01&rft.volume=27&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2015.36 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Mathematical models; Urine; Uranium; Radioactive materials; Bioassays; Occupational exposure DO - http://dx.doi.org/10.1038/jes.2015.36 ER - TY - JOUR T1 - Mortality in a combined cohort of uranium enrichment workers AN - 1855072458; PQ0003960548 AB - Objective To examine the patterns of cause-specific mortality and relationship between internal exposure to uranium and specific causes in a pooled cohort of 29,303 workers employed at three former uranium enrichment facilities in the United States with follow-up through 2011. Methods Cause-specific standardized mortality ratios (SMRs) for the full cohort were calculated with the U.S. population as referent. Internal comparison of the dose-response relation between selected outcomes and estimated organ doses was evaluated using regression models. Results External comparison with the U.S. population showed significantly lower SMRs in most diseases in the pooled cohort. Internal comparison showed positive associations of absorbed organ doses with multiple myeloma, and to a lesser degree with kidney cancer. Conclusion In general, these gaseous diffusion plant workers had significantly lower SMRs than the U.S. population. The internal comparison however, showed associations between internal organ doses and diseases associated with uranium exposure in previous studies. Am. J. Ind. Med. 60:96-108, 2017. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Yiin, James H AU - Anderson, Jeri L AU - Daniels, Robert D AU - Bertke, Stephen J AU - Fleming, Donald A AU - Tollerud, David J AU - Tseng, Chih-Yu AU - Chen, Pi-Hsueh AU - Waters, Kathleen M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 96 EP - 108 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 1 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Organs KW - Cancer KW - Workers KW - USA KW - Multiple myeloma KW - Dose-response effects KW - Uranium KW - Regression analysis KW - Standards KW - Diffusion KW - Occupational exposure KW - X 24390:Radioactive Materials KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855072458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+in+a+combined+cohort+of+uranium+enrichment+workers&rft.au=Yiin%2C+James+H%3BAnderson%2C+Jeri+L%3BDaniels%2C+Robert+D%3BBertke%2C+Stephen+J%3BFleming%2C+Donald+A%3BTollerud%2C+David+J%3BTseng%2C+Chih-Yu%3BChen%2C+Pi-Hsueh%3BWaters%2C+Kathleen+M&rft.aulast=Yiin&rft.aufirst=James&rft.date=2017-01-01&rft.volume=60&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22668 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Workers; Mortality; Multiple myeloma; Uranium; Regression analysis; Diffusion; Cancer; Occupational exposure; Dose-response effects; Standards; Organs; USA DO - http://dx.doi.org/10.1002/ajim.22668 ER - TY - JOUR T1 - Genotoxicity and gene expression analyses of liver and lung tissues of mice treated with titanium dioxide nanoparticles. AN - 1852785796; 28011748 AB - Titanium dioxide nanoparticles (TiO2 NPs) are used in paints, plastics, papers, inks, foods, toothpaste, pharmaceuticals and cosmetics. However, TiO2 NPs cause inflammation, pulmonary damage, fibrosis and lung tumours in animals and are possibly carcinogenic to humans. Although there are a large number of studies on the toxicities of TiO2 NPs, the data are inconclusive and the mechanisms underlying the toxicity are not clear. In this study, we used the Comet assay to evaluate genotoxicity and whole-genome microarray technology to analyse gene expression pattern in vivo to explore the possible mechanisms for toxicity and genotoxicity of TiO2 NPs. Mice were treated with three daily i.p. injections of 50 mg/kg 10 nm anatase TiO2 NPs and sacrificed 4 h after the last treatment. The livers and lungs were then isolated for the Comet assay and whole genome microarray analysis of gene expression. The NPs were heavily accumulated in liver and lung tissues. However, the treatment was positive for DNA strand breaks only in liver measured with the standard Comet assay, but positive for oxidative DNA adducts in both liver and lung as determined with the enzyme-modified Comet assay. The genotoxicity results suggest that DNA damage mainly resulted from oxidised nucleotides. Gene expression profiles and functional analyses revealed that exposure to TiO2 NPs triggered distinct gene expression patterns in both liver and lung tissues. The gene expression results suggest that TiO2 NPs impair DNA and cells by interrupting metabolic homeostasis in liver and by inducing oxidative stress, inflammatory responses and apoptosis in lung. These findings have broad implications when evaluating the safety of TiO2 NPs used in numerous consumer products. Published by Oxford University Press on behalf of The UK Environmental Mutagen Society 2016. JF - Mutagenesis AU - Li, Yan AU - Yan, Jian AU - Ding, Wei AU - Chen, Ying AU - Pack, Lindsay M AU - Chen, Tao AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA. ; Nanotechnology Core Facility, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA, tao.chen@fda.hhs.gov. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 33 EP - 46 VL - 32 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852785796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Genotoxicity+and+gene+expression+analyses+of+liver+and+lung+tissues+of+mice+treated+with+titanium+dioxide+nanoparticles.&rft.au=Li%2C+Yan%3BYan%2C+Jian%3BDing%2C+Wei%3BChen%2C+Ying%3BPack%2C+Lindsay+M%3BChen%2C+Tao&rft.aulast=Li&rft.aufirst=Yan&rft.date=2017-01-01&rft.volume=164&rft.issue=1-2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncu370 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/gew065 ER - TY - JOUR T1 - Factors affecting the in vitro micronucleus assay for evaluation of nanomaterials. AN - 1852784343; 27567283 AB - A number of in vitro methodologies have been used to assess the genotoxicity of different nanomaterials, including titanium dioxide nanoparticles (TiO2 NPs) and silver nanoparticles (AgNPs). The in vitro micronucleus assay is one of the most commonly used test methods for genotoxicity evaluation of nanomaterials. However, due to the novel features of nanomaterials, such as high adsorption capacity and fluorescence properties, there are unexpected interactions with experimental components and detection systems. In this study, we evaluate the interference by two nanoparticles, AgNPs and TiO2 NPs, with the in vitro micronucleus assay system and possible confounding factors affecting cytotoxicity and genotoxicity assessment of the nanomaterials including cell lines with different p53 status, nanoparticle coatings and fluorescence, cytochalasin B, fetal bovine serum in cell treatment medium and different measurement methodologies for detecting micronuclei. Our results showed that micronucleus induction by AgNPs was similar when evaluated using flow cytometry or microscope, whereas the induction by TiO2 NPs was different using the two methods due to TiO2's fluorescence interference with the cytometry equipment. Cells with the mutated p53 gene were more sensitive to micronucleus induction by AgNPs than the p53 wild-type cells. The presence of serum during treatment increased the toxicity of AgNPs. The coatings of nanoparticles played an important role in the genotoxicity of AgNPs. These collective data highlight the importance of considering the unique properties of nanoparticles in assessing their genotoxicity using the in vitro micronucleus assay. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society 2016. JF - Mutagenesis AU - Li, Yan AU - Doak, Shareen H AU - Yan, Jian AU - Chen, David H AU - Zhou, Min AU - Mittelstaedt, Roberta A AU - Chen, Ying AU - Li, Chun AU - Chen, Tao AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. ; Institute of Life Science, Swansea University Medical School, Singleton Park, Swansea SA2 8PP, Wales, UK. ; Columbia College, Columbia University in the City of New York, 2960 Broadway, New York, NY 10027, USA and. ; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, 1881 East Road, Houston, TX 77054, USA. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA, tao.chen@fda.hhs.gov. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 151 EP - 159 VL - 32 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852784343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Factors+affecting+the+in+vitro+micronucleus+assay+for+evaluation+of+nanomaterials.&rft.au=Li%2C+Yan%3BDoak%2C+Shareen+H%3BYan%2C+Jian%3BChen%2C+David+H%3BZhou%2C+Min%3BMittelstaedt%2C+Roberta+A%3BChen%2C+Ying%3BLi%2C+Chun%3BChen%2C+Tao&rft.aulast=Li&rft.aufirst=Yan&rft.date=2017-01-01&rft.volume=32&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgew040 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/gew040 ER - TY - JOUR T1 - Adapting viral safety assurance strategies to continuous processing of biological products AN - 1850784785; PQ0003918271 AB - There has been a recent drive in commercial large-scale production of biotechnology products to convert current batch mode processing to continuous processing manufacturing. There have been reports of model systems capable of adapting and linking upstream and downstream technologies into a continuous manufacturing pipeline. However, in many of these proposed continuous processing model systems, viral safety has not been comprehensively addressed. Viral safety and detection is a highly important and often expensive regulatory requirement for any new biological product. To ensure success in the adaption of continuous processing to large-scale production, there is a need to consider the development of approaches that allow for seamless incorporation of viral testing and clearance/inactivation methods. In this review, we outline potential strategies to apply current viral testing and clearance/inactivation technologies to continuous processing, as well as modifications of existing unit operations to ensure the successful integration of viral clearance into the continuous processing of biological products. Biotechnol. Bioeng. 2017; 114: 21-32. Viral safety and detection is a highly important and often expensive regulatory requirement for any new biological product. In the figure, the authors present a theoretical model of viral safety and detection integration into continuous processing. In this review, they outline potential strategies to apply current/novel viral testing and clearance/inactivation technologies to continuous processing, as well as modifications of existing unit operations to ensure the successful integration of viral clearance into the continuous processing of biological products. JF - Biotechnology and Bioengineering AU - Johnson, Sarah A AU - Brown, Matthew R AU - Lute, Scott C AU - Brorson, Kurt A AD - DBRRII, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, 20993. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 21 EP - 32 PB - Wiley Subscription Services VL - 114 IS - 1 SN - 0006-3592, 0006-3592 KW - Biotechnology and Bioengineering Abstracts KW - Integration KW - Models KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850784785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=Adapting+viral+safety+assurance+strategies+to+continuous+processing+of+biological+products&rft.au=Johnson%2C+Sarah+A%3BBrown%2C+Matthew+R%3BLute%2C+Scott+C%3BBrorson%2C+Kurt+A&rft.aulast=Johnson&rft.aufirst=Sarah&rft.date=2017-01-01&rft.volume=114&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=00063592&rft_id=info:doi/10.1002%2Fbit.26060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Integration; Models DO - http://dx.doi.org/10.1002/bit.26060 ER - TY - JOUR T1 - Autophagy function and its relationship to pathology, clinical applications, drug metabolism and toxicity AN - 1850780126; PQ0003920573 AB - Autophagy is a cellular process that facilitates nutrient turnover and removal of expended macromolecules and organelles to maintain homeostasis. The recycling of cytosolic macromolecules and damaged organelles by autophagosomes occurs through the lysosomal degradation pathway. Autophagy can also be upregulated as a prosurvival pathway in response to stress stimuli such as starvation, hypoxia or cell damage. Over the last two decades, there has been a surge in research revealing the basic molecular mechanisms of autophagy in mammalian cells. A corollary of an advanced understanding of autophagy has been a concurrent expansion of research into understanding autophagic function and dysfunction in pathology. Recent studies have revealed a pivotal role for autophagy in drug toxicity, and for utilizing autophagic components as diagnostic markers and therapeutic targets in treating disease and cancer. In this review, advances in understanding the molecular basis of mammalian autophagy, methods used to induce and evaluate autophagy, and the diverse interactions between autophagy and drug toxicity, disease progression and carcinogenesis are discussed. Autophagy has a critical role in maintaining cellular homeostasis and overall health, as loss of autophagic function is implicated in disease and cancer. Recent studies have revealed a pivotal role for autophagy in drug toxicity, and for utilizing autophagic components as diagnostic markers and therapeutic targets. In this review, we discuss advances in understanding the molecular basis of mammalian autophagy, methods to measure autophagy and the diverse interactions between autophagy and drug toxicity, disease progression and carcinogenesis. JF - Journal of Applied Toxicology AU - Petibone, Dayton M AU - Majeed, Waqar AU - Casciano, Daniel A AD - National Center for Toxicological Research, US FDA, Division of Genetic and Molecular Toxicology, Jefferson, AR, 72079, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 23 EP - 37 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 37 IS - 1 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - Molecular modelling KW - Macromolecules KW - Pathology KW - Degradation KW - Phagosomes KW - Therapeutic applications KW - Nutrients KW - Homeostasis KW - Recycling KW - Waste management KW - Mammalian cells KW - Phagocytosis KW - Drugs KW - Starvation KW - Drug metabolism KW - Stress KW - Drug development KW - Toxicity KW - Cancer KW - Hypoxia KW - Carcinogenesis KW - Organelles KW - Metabolism KW - Lysosomes KW - X 24310:Pharmaceuticals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850780126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Autophagy+function+and+its+relationship+to+pathology%2C+clinical+applications%2C+drug+metabolism+and+toxicity&rft.au=Petibone%2C+Dayton+M%3BMajeed%2C+Waqar%3BCasciano%2C+Daniel+A&rft.aulast=Petibone&rft.aufirst=Dayton&rft.date=2017-01-01&rft.volume=37&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Starvation; Molecular modelling; Macromolecules; Drug metabolism; Phagosomes; Therapeutic applications; Stress; Drug development; Nutrients; Toxicity; Homeostasis; Recycling; Cancer; Mammalian cells; Hypoxia; Carcinogenesis; Phagocytosis; Organelles; Lysosomes; Degradation; Pathology; Drugs; Metabolism; Waste management DO - http://dx.doi.org/10.1002/jat.3393 ER - TY - JOUR T1 - Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. AN - 1847885692; 27537422 AB - In an evaluation of carbon nanotubes (CNTs) for the IARC Monograph 111, the Mechanisms Subgroup was tasked with assessing the strength of evidence on the potential carcinogenicity of CNTs in humans. The mechanistic evidence was considered to be not strong enough to alter the evaluations based on the animal data. In this paper, we provide an extended, in-depth examination of the in vivo and in vitro experimental studies according to current hypotheses on the carcinogenicity of inhaled particles and fibers. We cite additional studies of CNTs that were not available at the time of the IARC meeting in October 2014, and extend our evaluation to include carbon nanofibers (CNFs). Finally, we identify key data gaps and suggest research needs to reduce uncertainty. The focus of this review is on the cancer risk to workers exposed to airborne CNT or CNF during the production and use of these materials. The findings of this review, in general, affirm those of the original evaluation on the inadequate or limited evidence of carcinogenicity for most types of CNTs and CNFs at this time, and possible carcinogenicity of one type of CNT (MWCNT-7). The key evidence gaps to be filled by research include: investigation of possible associations between in vitro and early-stage in vivo events that may be predictive of lung cancer or mesothelioma, and systematic analysis of dose-response relationships across materials, including evaluation of the influence of physico-chemical properties and experimental factors on the observation of nonmalignant and malignant endpoints. JF - Critical reviews in toxicology AU - Kuempel, Eileen D AU - Jaurand, Marie-Claude AU - Møller, Peter AU - Morimoto, Yasuo AU - Kobayashi, Norihiro AU - Pinkerton, Kent E AU - Sargent, Linda M AU - Vermeulen, Roel C H AU - Fubini, Bice AU - Kane, Agnes B AD - a National Institute for Occupational Safety and Health , Cincinnati , OH , USA. ; b Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche , UMR 1162 , Paris , France. ; f Department of Public Health , University of Copenhagen , Copenhagen , Denmark. ; g Department of Occupational Pneumology , University of Occupational and Environmental Health , Kitakyushu City , Japan. ; h National Institute of Health Sciences , Tokyo , Japan. ; i Center for Health and the Environment, University of California , Davis , California , USA. ; j National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA. ; k Institute for Risk Assessment Sciences, Utrecht University , Utrecht , The Netherlands. ; l Department of Chemistry and "G.Scansetti" Interdepartmental Center , Università degli Studi di Torino , Torino , Italy. ; m Department of Pathology and Laboratory Medicine , Brown University , Providence , RI , USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1 EP - 58 VL - 47 IS - 1 KW - inflammation KW - lung cancer KW - Cancer mechanisms KW - genotoxicity KW - carbon nanotubes KW - cell proliferation KW - particle retention KW - pulmonary KW - mesothelioma KW - translocation KW - fibrosis KW - carbon nanofibers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1847885692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+toxicology&rft.atitle=Evaluating+the+mechanistic+evidence+and+key+data+gaps+in+assessing+the+potential+carcinogenicity+of+carbon+nanotubes+and+nanofibers+in+humans.&rft.au=Kuempel%2C+Eileen+D%3BJaurand%2C+Marie-Claude%3BM%C3%B8ller%2C+Peter%3BMorimoto%2C+Yasuo%3BKobayashi%2C+Norihiro%3BPinkerton%2C+Kent+E%3BSargent%2C+Linda+M%3BVermeulen%2C+Roel+C+H%3BFubini%2C+Bice%3BKane%2C+Agnes+B&rft.aulast=Kuempel&rft.aufirst=Eileen&rft.date=2017-01-01&rft.volume=14&rft.issue=4&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Drug+discovery&rft.issn=1474-1784&rft_id=info:doi/10.1038%2Fnrd3845-c1 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-02-13 N1 - Last updated - 2017-02-13 DO - http://dx.doi.org/10.1080/10408444.2016.1206061 ER - TY - JOUR T1 - Polybrominated diphenyl ethers (PBDES) and hexa-brominated biphenyls (Hexa-BBs) in fresh foods ingested in Taiwan. AN - 1844024729; 27884471 AB - Polybrominated diphenyl ethers (PBDEs) and hexa-brominated biphenyls (Hexa-BBs) are bioaccumulative and aggregate in the food chain. Therefore, background monitoring and risk assessment for dietary intake are necessary. In present study, a systematic sampling method was first used to collect the high fat content foodstuff such as poultry, livestock, eggs, fish, other seafood, dairy products, and the infant foods and then foodstuff with high consumption in seven categories of 600 food samples. After integrating four years of background surveys of PBDE levels (2010-2013) and one year of that of Hexa-BBs (2013), the highest estimated daily intake (EDI) of PBDEs for Taiwanese food consumption was found in 0- to 3-year-olds (mean = 9.38 ng kg-1 bw d-1, the 95% upper limit of Monte Carlo Simulation (MCS P95) was 21.52 ng kg-1 bw d-1), and the lowest in 16- to 18-year-old girls (mean = 3.35 ng kg-1 bw d-1, MCS P95 was 6.53 ng kg-1 bw d-1). Moreover, the highest of EDI of Hexa-BBs was found in 0-3 years old (mean = 0.007 ng kg-1 bw d-1, MCS P95 = 0.019 ng kg-1 bw d-1), and lowest in 17-18 years old female (mean = 0.002 ng/kg/day, MCS P95 = 0.005 ng kg-1 bw d-1). This study suggests that the large MOEs (>2.5) for the four important congeners BDE-47, -99, -153, and -209, indicate that the dietary exposures are not probably a significant health concern for Taiwanese. JF - Environmental pollution (Barking, Essex : 1987) AU - Chang, Jung-Wei AU - Hung, Chung-Feng AU - Hsu, Ya-Chen AU - Kao, Yi-Ting AU - Lee, Ching-Chang AD - Research Center for Environmental Trace Toxic Substances, National Cheng Kung University, Tainan, Taiwan. ; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, Taiwan. ; Research Center for Environmental Trace Toxic Substances, National Cheng Kung University, Tainan, Taiwan; Department of Environmental and Occupational Health, National Cheng Kung University College of Medicine, Taiwan. Electronic address: cclee@mail.ncku.edu.tw. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1180 EP - 1189 VL - 220 KW - Risk assessment KW - Food KW - Polybrominated diphenyl ethers (PBDEs) KW - Hexa-brominated biphenyls (Hexa-BBs) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844024729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.atitle=Polybrominated+diphenyl+ethers+%28PBDES%29+and+hexa-brominated+biphenyls+%28Hexa-BBs%29+in+fresh+foods+ingested+in+Taiwan.&rft.au=Chang%2C+Jung-Wei%3BHung%2C+Chung-Feng%3BHsu%2C+Ya-Chen%3BKao%2C+Yi-Ting%3BLee%2C+Ching-Chang&rft.aulast=Chang&rft.aufirst=Jung-Wei&rft.date=2017-01-01&rft.volume=220&rft.issue=&rft.spage=1180&rft.isbn=&rft.btitle=&rft.title=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.issn=1873-6424&rft_id=info:doi/10.1016%2Fj.envpol.2016.11.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-25 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1016/j.envpol.2016.11.017 ER - TY - GEN T1 - A comment on the discussion and application of statistical methods in Mandrup et al. Low-dose effects of bisphenol A on mammary gland development in rats (Andrology 4: 673-683, 2016). AN - 1842601015; 27871129 JF - Andrology AU - Felton, R P AU - Juliar, B E AU - Olson, G R AU - Delclos, K B Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 194 EP - 195 VL - 5 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842601015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Andrology&rft.atitle=A+comment+on+the+discussion+and+application+of+statistical+methods+in+Mandrup+et%C2%A0al.+Low-dose+effects+of+bisphenol+A+on+mammary+gland+development+in+rats+%28Andrology+4%3A+673-683%2C+2016%29.&rft.au=Felton%2C+R+P%3BJuliar%2C+B+E%3BOlson%2C+G+R%3BDelclos%2C+K+B&rft.aulast=Felton&rft.aufirst=R&rft.date=2017-01-01&rft.volume=5&rft.issue=1&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Andrology&rft.issn=2047-2927&rft_id=info:doi/10.1111%2Fandr.12298 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/andr.12298 ER - TY - JOUR T1 - Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study. AN - 1842600255; 27871980 AB - Furan is a volatile organic chemical that is a contaminant in many common foods. Furan is hepatocarcinogenic in mice and rats; however, the risk to humans from dietary exposure to furan cannot be estimated accurately because the lowest tested dose of furan in a 2-year bioassay in rats gave nearly a 100% incidence of cholangiocarcinoma. To provide bioassay data that can be used in preparing risk assessments, the carcinogenicity of furan was determined in male F344/N Nctr rats administered 0, 0.02, 0.044, 0.092, 0.2, 0.44, 0.92, and 2 mg furan/kg body weight (BW) by gavage 5 days/week for 2 years. Exposure to furan was associated with the development of malignant mesothelioma on membranes surrounding the epididymis and on the testicular tunics, with the increase being significant at 2 mg furan/kg BW. There was also a dose-related increase in the incidence of mononuclear cell leukemia, with the increase in incidence being significant at 0.092, 0.2, 0.92, and 2 mg furan/kg BW. Dose-related non-neoplastic liver lesions included cholangiofibrosis, mixed cell foci, basophilic foci, biliary tract hyperplasia, oval cell hyperplasia, regenerative hyperplasia, and cytoplasmic vacuolization. The most sensitive non-neoplastic lesion was cholangiofibrosis, the frequency of which increased significantly at 0.2 mg furan/kg BW. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Von Tungeln, Linda S AU - Walker, Nigel J AU - Olson, Greg R AU - Mendoza, Maria C B AU - Felton, Robert P AU - Thorn, Brett T AU - Marques, M Matilde AU - Pogribny, Igor P AU - Doerge, Daniel R AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States. ; Toxicologic Pathology Associates, Jefferson, AR 72079, United States. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. Electronic address: frederick.beland@fda.hhs.gov. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 170 EP - 181 VL - 99 KW - Rats KW - Cholangiocarcinoma KW - Cholangiofibrosis KW - Furan KW - Tumorigenicity KW - Bioassay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842600255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Low+dose+assessment+of+the+carcinogenicity+of+furan+in+male+F344%2FN+Nctr+rats+in+a+2-year+gavage+study.&rft.au=Von+Tungeln%2C+Linda+S%3BWalker%2C+Nigel+J%3BOlson%2C+Greg+R%3BMendoza%2C+Maria+C+B%3BFelton%2C+Robert+P%3BThorn%2C+Brett+T%3BMarques%2C+M+Matilde%3BPogribny%2C+Igor+P%3BDoerge%2C+Daniel+R%3BBeland%2C+Frederick+A&rft.aulast=Von+Tungeln&rft.aufirst=Linda&rft.date=2017-01-01&rft.volume=99&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.11.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.11.015 ER - TY - JOUR T1 - MicroRNA biomarkers of pancreatic injury in a canine model. AN - 1842549730; 27866884 AB - Pancreas-enriched microRNAs have been experimentally investigated in rodents as candidate serum biomarkers of pancreatic injury with several different acute pancreatic injury models. In the present study, temporal and magnitude responses of exocrine pancreas-enriched miR-216a, miR-216b, and miR-217 and endocrine-enriched miR-375 and miR-148a were measured by droplet digital PCR in serum in a caerulein model of pancreatic injury in the dog. All 5 microRNAs followed a similar time course that mirrored the responses of the conventional serum pancreatic injury biomarkers, amylase and lipase. Detection was improved through the use of assays designed against microRNA isomers (isomirs) identified by sequencing. Serum biomarker increases were concordant with histopathology defined acinar cell injury. Minimal islet cell changes were noted. The pancreas-enriched microRNAs demonstrated similar or greater sensitivity, a larger range of response, and a higher correlation to acinar cell injury compared to amylase and lipase. Our results further support the translational potential of pancreas-enriched microRNAs as sensitive biomarkers of acinar cell injury with evidence from an additional non-clinical model system. Published by Elsevier GmbH. JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie AU - Rouse, Rodney AU - Rosenzweig, Barry AU - Shea, Katie AU - Knapton, Alan AU - Stewart, Sharron AU - Xu, Lin AU - Chockalingam, Ashok AU - Zadrozny, Leah AU - Thompson, Karol AD - U. S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science, HFD-910, White Oak Federal Research Center, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Electronic address: rodney.rouse@fda.hhs.gov. ; U. S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science, HFD-910, White Oak Federal Research Center, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 33 EP - 43 VL - 69 IS - 1 KW - miR-217 KW - Droplet digital PCR KW - miR-148a KW - Pancreas KW - MicroRNA KW - Isomirs KW - miR-375 KW - miR-216a KW - Biomarker KW - Pancreatitis KW - miR-216b UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842549730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+toxicologic+pathology+%3A+official+journal+of+the+Gesellschaft+fur+Toxikologische+Pathologie&rft.atitle=MicroRNA+biomarkers+of+pancreatic+injury+in+a+canine+model.&rft.au=Rouse%2C+Rodney%3BRosenzweig%2C+Barry%3BShea%2C+Katie%3BKnapton%2C+Alan%3BStewart%2C+Sharron%3BXu%2C+Lin%3BChockalingam%2C+Ashok%3BZadrozny%2C+Leah%3BThompson%2C+Karol&rft.aulast=Rouse&rft.aufirst=Rodney&rft.date=2017-01-01&rft.volume=69&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Experimental+and+toxicologic+pathology+%3A+official+journal+of+the+Gesellschaft+fur+Toxikologische+Pathologie&rft.issn=1618-1433&rft_id=info:doi/10.1016%2Fj.etp.2016.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.etp.2016.11.001 ER - TY - JOUR T1 - Behavioral interventions to reduce HIV risk behavior for MSM and transwomen in Southeast Asia: a systematic review AN - 1841801999 AB - This systematic review aims to gain insights from existing literature from Southeast Asian countries to improve future HIV prevention programs for men who have sex with men (MSM) and transgender women (transwomen). We conducted a systematic search in six international databases for literature published prior to 1 January 2015. We included studies describing behavioral interventions targeting MSM and/or transwomen, and conducted in at least one Southeast Asian country. Five out of 575 screened studies met the inclusion criteria and reported a significant intervention effect on at least one outcome measure, that is, condom use (with casual or commercial partner), water-based lubricant use, number of sex partners, HIV prevention knowledge, or willingness to use pre-exposure prophylaxis. Peer education/outreach was the most commonly employed type of intervention in the five included studies and was usually delivered as an element of a larger intervention package, together with condom distribution and the provision of drop-in centers. Motivational interviewing was effective, while internet-based interventions appeared to be a viable platform for intervention delivery. Nevertheless, research on behavioral interventions among MSM and transwomen in Southeast Asia is limited. Future interventions should be culturally appropriate, theoretically grounded, and rigorously evaluated. Only then can we best address the HIV epidemic among MSM and transwomen in this region. JF - AIDS Care AU - Nugroho, Adi AU - Erasmus, Vicki AU - Zomer, Tizza P AU - Wu, Qing AU - Richardus, Jan Hendrik AD - Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Public Health Study Program, Lambung Mangkurat University, Banjarbaru, Indonesia ; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands ; Department of Infectious Disease Control, Municipal Public Health Service of Rotterdam-Rijnmond, Rotterdam, The Netherlands ; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Public Health Study Program, Lambung Mangkurat University, Banjarbaru, Indonesia Y1 - 2017/01// PY - 2017 DA - Jan 2017 SP - 98 EP - 104 CY - London PB - Taylor & Francis Ltd. VL - 29 IS - 1 SN - 0954-0121 KW - Medical Sciences--Psychiatry And Neurology KW - MSM KW - transgender KW - behavioral intervention KW - Southeast Asia KW - review KW - Human immunodeficiency virus--HIV KW - Behavior modification KW - Disease prevention KW - Transgender persons KW - Water KW - Inclusive education KW - Risk reduction KW - Preventive health care KW - Risk behaviour KW - Transsexuality KW - Motivational interviewing KW - Sex education KW - Databases KW - Interventions KW - HIV KW - Outreach programmes KW - Homosexuals KW - Systematic reviews KW - Preventive programmes KW - Willingness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1841801999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Behavioral+interventions+to+reduce+HIV+risk+behavior+for+MSM+and+transwomen+in+Southeast+Asia%3A+a+systematic+review&rft.au=Nugroho%2C+Adi%3BErasmus%2C+Vicki%3BZomer%2C+Tizza+P%3BWu%2C+Qing%3BRichardus%2C+Jan+Hendrik&rft.aulast=Nugroho&rft.aufirst=Adi&rft.date=2017-01-01&rft.volume=29&rft.issue=1&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2016.1200713 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © 2016 Informa UK Limited, trading as Taylor & Francis Group N1 - Last updated - 2017-01-26 N1 - SubjectsTermNotLitGenreText - Southeast Asia DO - http://dx.doi.org/10.1080/09540121.2016.1200713 ER - TY - JOUR T1 - Estimation of iodine nutrition and thyroid function status in late-gestation pregnant women in the United States: Development and application of a population-based pregnancy model. AN - 1837031165; 27818216 AB - Previously, a deterministic biologically-based dose-response (BBDR) pregnancy model was developed to evaluate moderate thyroid axis disturbances with and without thyroid-active chemical exposure in a near-term pregnant woman and fetus. In the current study, the existing BBDR model was adapted to include a wider functional range of iodine nutrition, including more severe iodine deficiency conditions, and to incorporate empirically the effects of homeostatic mechanisms. The extended model was further developed into a population-based model and was constructed using a Monte Carlo-based probabilistic framework. In order to characterize total (T4) and free (fT4) thyroxine levels for a given iodine status at the population-level, the distribution of iodine intake for late-gestation pregnant women in the U.S was reconstructed using various reverse dosimetry methods and available biomonitoring data. The range of median (mean) iodine intake values resulting from three different methods of reverse dosimetry tested was 196.5-219.9μg of iodine/day (228.2-392.9μg of iodine/day). There was minimal variation in model-predicted maternal serum T4 and ft4 thyroxine levels from use of the three reconstructed distributions of iodine intake; the range of geometric mean for T4 and fT4, was 138-151.7nmol/L and 7.9-8.7pmol/L, respectively. The average value of the ratio of the 97.5th percentile to the 2.5th percentile equaled 3.1 and agreed well with similar estimates from recent observations in third-trimester pregnant women in the U.S. In addition, the reconstructed distributions of iodine intake allowed us to estimate nutrient inadequacy for late-gestation pregnant women in the U.S. via the probability approach. The prevalence of iodine inadequacy for third-trimester pregnant women in the U.S. was estimated to be between 21% and 44%. Taken together, the current work provides an improved tool for evaluating iodine nutritional status and the corresponding thyroid function status in pregnant women in the U.S. This model enables future assessments of the relevant risk of thyroid hormone level perturbations due to exposure to thyroid-active chemicals at the population-level. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Lumen, A AU - George, N I AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Annie.Lumen@fda.hhs.gov. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Nysia.George@fda.hhs.gov. Y1 - 2017/01/01/ PY - 2017 DA - 2017 Jan 01 SP - 24 EP - 38 VL - 314 KW - Thyroid hormones KW - Biologically-base dose-response modeling KW - Biomonitoring KW - Iodine KW - Reverse dosimetry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837031165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Estimation+of+iodine+nutrition+and+thyroid+function+status+in+late-gestation+pregnant+women+in+the+United+States%3A+Development+and+application+of+a+population-based+pregnancy+model.&rft.au=Lumen%2C+A%3BGeorge%2C+N+I&rft.aulast=Lumen&rft.aufirst=A&rft.date=2017-01-01&rft.volume=314&rft.issue=&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.10.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.10.026 ER - TY - JOUR T1 - The impact of perceived intensity and frequency of police work occupational stressors on the cortisol awakening response (CAR): Findings from the BCOPS study. AN - 1837025413; 27816820 AB - Police officers encounter unpredictable, evolving, and escalating stressful demands in their work. Utilizing the Spielberger Police Stress Survey (60-item instrument for assessing specific conditions or events considered to be stressors in police work), the present study examined the association of the top five highly rated and bottom five least rated work stressors among police officers with their awakening cortisol pattern. Participants were police officers enrolled in the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) study (n=338). For each group, the total stress index (product of rating and frequency of the stressor) was calculated. Participants collected saliva by means of Salivettes at four time points: on awakening, 15, 30 and 45min after waking to examine the cortisol awakening response (CAR). Saliva samples were analyzed for free cortisol concentrations. A slope reflecting the awakening pattern of cortisol over time was estimated by fitting a linear regression model relating cortisol in log-scale to time of collection. The slope served as the outcome variable. Analysis of covariance, regression, and repeated measures models were used to determine if there was an association of the stress index with the waking cortisol pattern. There was a significant negative linear association between total stress index of the five highest stressful events and slope of the awakening cortisol regression line (trend p-value=0.0024). As the stress index increased, the pattern of the awakening cortisol regression line tended to flatten. Officers with a zero stress index showed a steep and steady increase in cortisol from baseline (which is often observed) while officers with a moderate or high stress index showed a dampened or flatter response over time. Conversely, the total stress index of the five least rated events was not significantly associated with the awakening cortisol pattern. The study suggests that police events or conditions considered highly stressful by the officers may be associated with disturbances of the typical awakening cortisol pattern. The results are consistent with previous research where chronic exposure to stressors is associated with a diminished awakening cortisol response pattern. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Psychoneuroendocrinology AU - Violanti, John M AU - Fekedulegn, Desta AU - Andrew, Michael E AU - Hartley, Tara A AU - Charles, Luenda E AU - Miller, Diane B AU - Burchfiel, Cecil M AD - Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY, USA. Electronic address: violanti@buffalo.edu. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: djf7@cdc.gov. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: mta6@cdc.gov. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: tow9@cdc.gov. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: ley0@cdc.gov. ; Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: dum6@cdc.gov. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: zar5@cdc.gov. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 124 EP - 131 VL - 75 KW - CAR KW - Police KW - Psychosocial stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837025413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychoneuroendocrinology&rft.atitle=The+impact+of+perceived+intensity+and+frequency+of+police+work+occupational+stressors+on+the+cortisol+awakening+response+%28CAR%29%3A+Findings+from+the+BCOPS+study.&rft.au=Violanti%2C+John+M%3BFekedulegn%2C+Desta%3BAndrew%2C+Michael+E%3BHartley%2C+Tara+A%3BCharles%2C+Luenda+E%3BMiller%2C+Diane+B%3BBurchfiel%2C+Cecil+M&rft.aulast=Violanti&rft.aufirst=John&rft.date=2017-01-01&rft.volume=75&rft.issue=&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Psychoneuroendocrinology&rft.issn=1873-3360&rft_id=info:doi/10.1016%2Fj.psyneuen.2016.10.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.psyneuen.2016.10.017 ER - TY - JOUR T1 - A Brief Overview of the STP 35th Annual Symposium on the Basis and Relevance of Variation in Toxicologic Responses. AN - 1836736439; 27815490 AB - The title of the 2016 Society of Toxicologic Pathology (STP) Symposium was the "Basis and Relevance of Variation in Toxicologic Responses." Many factors may contribute to variation in toxicologic responses and can confound results, complicate interpretation of data, interfere with reproducibility, and make extrapolation to humans problematic. This brief overview summarizes speaker presentations from each session which describes important factors that may impact the interpretation of nonclinical discovery and developmental toxicity studies. In addition, summaries of the Continuing Education (CE) courses and other educational events that occurred during the Symposium are highlighted. JF - Toxicologic pathology AU - Irizarry, Armando R AU - Gropp, Kathryn E AU - Dixon, Darlene AD - 1 Eli Lilly & Company, Indianapolis, Indiana, USA. ; 2 Pfizer Inc., Groton, Connecticut, USA. ; 3 National Institute of Environmental Health Sciences and the National Toxicology Program, National Institutes of Health (NIH), U.S. Department of Health and Human Services (HHS), Research Triangle Park, North Carolina, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 52 EP - 56 VL - 45 IS - 1 KW - Toxicologic Pathology KW - clinical pathology KW - variation KW - nonclinical toxicity studies KW - toxicology KW - toxicologic responses KW - annual symposium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1836736439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=A+Brief+Overview+of+the+STP+35th+Annual+Symposium+on+the+Basis+and+Relevance+of+Variation+in+Toxicologic+Responses.&rft.au=Irizarry%2C+Armando+R%3BGropp%2C+Kathryn+E%3BDixon%2C+Darlene&rft.aulast=Irizarry&rft.aufirst=Armando&rft.date=2017-01-01&rft.volume=45&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623316675765 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623316675765 ER - TY - JOUR T1 - The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study. AN - 1836733204; 27810988 AB - Little is known about arsenic and diabetes in youth. We examined the association of arsenic with type 1 and type 2 diabetes in the SEARCH for Diabetes in Youth Case-Control (SEARCH-CC) study. Because one-carbon metabolism can influence arsenic metabolism, we also evaluated the potential interaction of folate and vitamin B12 with arsenic metabolism on the odds of diabetes. Six hundred eighty-eight participants <22 years of age (429 with type 1 diabetes, 85 with type 2 diabetes, and 174 control participants) were evaluated. Arsenic species (inorganic arsenic [iAs], monomethylated arsenic [MMA], dimethylated arsenic [DMA]), and one-carbon metabolism biomarkers (folate and vitamin B12) were measured in plasma. We used the sum of iAs, MMA, and DMA (∑As) and the individual species as biomarkers of arsenic concentrations and the relative proportions of the species over their sum (iAs%, MMA%, DMA%) as biomarkers of arsenic metabolism. Median ∑As, iAs%, MMA%, and DMA% were 83.1 ng/L, 63.4%, 10.3%, and 25.2%, respectively. ∑As was not associated with either type of diabetes. The fully adjusted odds ratios (95% CI), rescaled to compare a difference in levels corresponding to the interquartile range of iAs%, MMA%, and DMA%, were 0.68 (0.50-0.91), 1.33 (1.02-1.74), and 1.28 (1.01-1.63), respectively, for type 1 diabetes and 0.82 (0.48-1.39), 1.09 (0.65-1.82), and 1.17 (0.77-1.77), respectively, for type 2 diabetes. In interaction analysis, the odds ratio of type 1 diabetes by MMA% was 1.80 (1.25-2.58) and 0.98 (0.70-1.38) for participants with plasma folate levels above and below the median (P for interaction = 0.02), respectively. Low iAs% versus high MMA% and DMA% was associated with a higher odds of type 1 diabetes, with a potential interaction by folate levels. These data support further research on the role of arsenic metabolism in type 1 diabetes, including the interplay with one-carbon metabolism biomarkers. © 2017 by the American Diabetes Association. JF - Diabetes care AU - Grau-Pérez, Maria AU - Kuo, Chin-Chi AU - Spratlen, Miranda AU - Thayer, Kristina A AU - Mendez, Michelle A AU - Hamman, Richard F AU - Dabelea, Dana AU - Adgate, John L AU - Knowler, William C AU - Bell, Ronny A AU - Miller, Frederick W AU - Liese, Angela D AU - Zhang, Chongben AU - Douillet, Christelle AU - Drobná, Zuzana AU - Mayer-Davis, Elizabeth J AU - Styblo, Miroslav AU - Navas-Acien, Ana AD - Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD mgraupe1@jhu.edu anavasa1@jhu.edu. ; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC. ; Department of Nutrition, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC. ; Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO. ; Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Denver, Aurora, CO. ; Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ. ; Wake Forest School of Medicine, Winston-Salem, NC. ; National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD. ; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 46 EP - 53 VL - 40 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1836733204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=The+Association+of+Arsenic+Exposure+and+Metabolism+With+Type+1+and+Type+2+Diabetes+in+Youth%3A+The+SEARCH+Case-Control+Study.&rft.au=Grau-P%C3%A9rez%2C+Maria%3BKuo%2C+Chin-Chi%3BSpratlen%2C+Miranda%3BThayer%2C+Kristina+A%3BMendez%2C+Michelle+A%3BHamman%2C+Richard+F%3BDabelea%2C+Dana%3BAdgate%2C+John+L%3BKnowler%2C+William+C%3BBell%2C+Ronny+A%3BMiller%2C+Frederick+W%3BLiese%2C+Angela+D%3BZhang%2C+Chongben%3BDouillet%2C+Christelle%3BDrobn%C3%A1%2C+Zuzana%3BMayer-Davis%2C+Elizabeth+J%3BStyblo%2C+Miroslav%3BNavas-Acien%2C+Ana&rft.aulast=Grau-P%C3%A9rez&rft.aufirst=Maria&rft.date=2017-01-01&rft.volume=40&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=1935-5548&rft_id=info:doi/10.2337%2Fdc16-0810 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2337/dc16-0810 ER - TY - JOUR T1 - Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury. AN - 1835689316; 27634590 AB - Overdose of acetaminophen (APAP) is a major cause of acute liver failure. This study was aimed to identify pathways related to hepatotoxicity and potential biomarkers of liver injury. Rats were treated with low (100 mg/kg) and high (1250 mg/kg) doses of APAP, and liver tissues at 6 and 24 h post-treatment were analyzed using a proteomic approach of 16O/18O labeling and 2D-LC-MS/MS. Molecular pathways evolved progressively from scattered and less significant perturbations to more focused and significant alterations in a dose- and time-dependent manner upon APAP treatment. Imbalanced expression of hemeoxygenase 1 (HMOX1) and biliverdin reductase A (BLVRA) was associated with hepatotoxicity. Protein abundance changes of a total of 31 proteins were uniquely correlated to liver damage, among which a dramatic increase of HMOX1 levels in plasma was observed. Liver injury-associated significant elevation of plasma HMOX1 was further validated in mice treated with APAP. This study unveiled molecular changes associated with APAP-induced liver toxicity at the pathway levels and identified HMOX1 as a potential plasma biomarker of liver injury. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Proteomics. Clinical applications AU - Gao, Yuan AU - Cao, Zhijun AU - Yang, Xi AU - Abdelmegeed, Mohamed A AU - Sun, Jinchun AU - Chen, Si AU - Beger, Richard D AU - Davis, Kelly AU - Salminen, William F AU - Song, Byoung-Joon AU - Mendrick, Donna L AU - Yu, Li-Rong AD - Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Toxicologic Pathology Associates, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 VL - 11 IS - 1-2 KW - Heme oxygenase 1 (HMOX1) KW - Hepatotoxicity KW - Acetaminophen KW - MS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835689316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=A+single+chimpanzee-human+neutralizing+monoclonal+antibody+provides+post-exposure+protection+against+type+1+and+type+2+polioviruses&rft.au=Kouiavskaia%2C+Diana%3BChen%2C+Zhaochun%3BDragunsky%2C+Eugenia%3BMirochnitchenko%2C+Olga%3BPurcell%2C+Robert%3BChumakov%2C+Konstantin&rft.aulast=Kouiavskaia&rft.aufirst=Diana&rft.date=2015-04-01&rft.volume=65&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2015.01.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/prca.201600123 ER - TY - JOUR T1 - FutureTox III: Bridges for Translation. AN - 1835685355; 27780885 AB - Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question-what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Juberg, Daland R AU - Knudsen, Thomas B AU - Sander, Miriam AU - Beck, Nancy B AU - Faustman, Elaine M AU - Mendrick, Donna L AU - Fowle, John R AU - Hartung, Thomas AU - Tice, Raymond R AU - Lemazurier, Emmanuel AU - Becker, Richard A AU - Fitzpatrick, Suzanne Compton AU - Daston, George P AU - Harrill, Alison AU - Hines, Ronald N AU - Keller, Douglas A AU - Lipscomb, John C AU - Watson, David AU - Bahadori, Tina AU - Crofton, Kevin M AD - Dow AgroSciences, Indianapolis, Indiana; drjuberg@dow.com. ; US Environmental Protection Agency, Research Triangle Park, North Carolina. ; Page One Editorial Services, Boulder, Colorado. ; American Chemistry Council, Washington, The District of Columbia. ; University of Washington, Seattle, Washington. ; US Food and Drug Administration, Silver Spring, Maryland. ; Science to Inform, LLC, Pittsboro, North Carolina. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. ; National Toxicology Program/National Institute of Environmental Health Sciences, Durham, North Carolina. ; INERIS-Chronic Risk Division, Verneeuil-en-Halatte, France. ; US Food and Drug Administration, College Park, Maryland. ; Procter & Gamble Company, Cincinnati, Ohio. ; University of Arkansas for Medical Sciences, Little Rock, Arkansas. ; Sanofi, Bridgewater, New Jersey. ; US Environmental Protection Agency, Cincinnati, Ohio. ; Lhasa Limited, Leeds, United Kingdom. ; US Environmental Protection Agency, Washington, The District of Columbia. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 22 EP - 31 VL - 155 IS - 1 KW - predictive toxicology KW - testing alternatives. KW - in vitro and alternatives KW - regulatory/policy KW - risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835685355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=FutureTox+III%3A+Bridges+for+Translation.&rft.au=Juberg%2C+Daland+R%3BKnudsen%2C+Thomas+B%3BSander%2C+Miriam%3BBeck%2C+Nancy+B%3BFaustman%2C+Elaine+M%3BMendrick%2C+Donna+L%3BFowle%2C+John+R%3BHartung%2C+Thomas%3BTice%2C+Raymond+R%3BLemazurier%2C+Emmanuel%3BBecker%2C+Richard+A%3BFitzpatrick%2C+Suzanne+Compton%3BDaston%2C+George+P%3BHarrill%2C+Alison%3BHines%2C+Ronald+N%3BKeller%2C+Douglas+A%3BLipscomb%2C+John+C%3BWatson%2C+David%3BBahadori%2C+Tina%3BCrofton%2C+Kevin+M&rft.aulast=Juberg&rft.aufirst=Daland&rft.date=2017-01-01&rft.volume=155&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw194 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw194 ER - TY - JOUR T1 - The U.S. Department of Veterans' Affairs depleted uranium exposed cohort at 25 Years: Longitudinal surveillance results. AN - 1835683400; 27792941 AB - A small group of Gulf War I veterans wounded in depleted uranium (DU) friendly-fire incidents have been monitored for health changes in a clinical surveillance program at the Veterans Affairs Medical Center, Baltimore since 1994. During the spring of 2015, an in-patient clinical surveillance protocol was performed on 36 members of the cohort, including exposure monitoring for total and isotopic uranium concentrations in urine and a comprehensive assessment of health outcomes. On-going mobilization of U from embedded fragments is evidenced by elevated urine U concentrations. The DU isotopic signature is observed principally in participants possessing embedded fragments. Those with only an inhalation exposure have lower urine U concentration and a natural isotopic signature. At 25 years since first exposure to DU, an aging cohort of military veterans continues to show no U-related health effects in known target organs of U toxicity. As U body burden continues to accrue from in-situ mobilization from metal fragment depots, and increases with exposure duration, critical tissue-specific U concentration thresholds may be reached, thus recommending on-going surveillance of this veteran cohort. Published by Elsevier Inc. JF - Environmental research AU - McDiarmid, Melissa A AU - Gaitens, Joanna M AU - Hines, Stella AU - Condon, Marian AU - Roth, Tracy AU - Oliver, Marc AU - Gucer, Patricia AU - Brown, Lawrence AU - Centeno, Jose A AU - Dux, Moira AU - Squibb, Katherine S AD - Department of Veterans Affairs Medical Center Baltimore, Maryland, 10 N. Greene St., Baltimore, MD 21201, USA; Department of Medicine, University of Maryland School of Medicine, 655 W Baltimore S, Baltimore, MD 21201, USA. ; Department of Veterans Affairs Medical Center Baltimore, Maryland, 10 N. Greene St., Baltimore, MD 21201, USA. Electronic address: mcondon@medicine.umaryland.edu. ; Department of Veterans Affairs Medical Center Baltimore, Maryland, 10 N. Greene St., Baltimore, MD 21201, USA; Department of Pathology, University of Maryland School of Medicine, 655 W Baltimore S, Baltimore, MD 21201, USA. ; US Food and Drug Administration, Center for Devices and Radiological Health Office of Science and Engineering Laboratories, Silver Spring, MD 20993, USA. ; Department of Veterans Affairs Medical Center Baltimore, Maryland, 10 N. Greene St., Baltimore, MD 21201, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 175 EP - 184 VL - 152 KW - Health surveillance KW - DU bio-monitoring KW - Uranium toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835683400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=The+U.S.+Department+of+Veterans%27+Affairs+depleted+uranium+exposed+cohort+at+25+Years%3A+Longitudinal+surveillance+results.&rft.au=McDiarmid%2C+Melissa+A%3BGaitens%2C+Joanna+M%3BHines%2C+Stella%3BCondon%2C+Marian%3BRoth%2C+Tracy%3BOliver%2C+Marc%3BGucer%2C+Patricia%3BBrown%2C+Lawrence%3BCenteno%2C+Jose+A%3BDux%2C+Moira%3BSquibb%2C+Katherine+S&rft.aulast=McDiarmid&rft.aufirst=Melissa&rft.date=2017-01-01&rft.volume=152&rft.issue=&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2016.10.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envres.2016.10.016 ER - TY - JOUR T1 - Toxicity evaluations of nanoclays and thermally degraded byproducts through spectroscopical and microscopical approaches. AN - 1835665794; 27612663 AB - Montmorillonite is a type of nanoclay that originates from the clay fraction of the soil and is incorporated into polymers to form nanocomposites with enhanced mechanical strength, barrier, and flammability properties used for food packaging, automotive, and medical devices. However, with implementation in such consumer applications, the interaction of montmorillonite-based composites or derived byproducts with biological systems needs to be investigated. Herein we examined the potential of Cloisite Na+ (pristine) and Cloisite 30B (organically modified montmorillonite nanoclay) and their thermally degraded byproducts' to induce toxicity in model human lung epithelial cells. The experimental set-up mimicked biological exposure in manufacturing and disposal areas and employed cellular treatments with occupationally relevant doses of nanoclays previously characterized using spectroscopical and microscopical approaches. For nanoclay-cellular interactions and for cellular analyses respectively, biosensorial-based analytical platforms were used, with induced cellular changes being confirmed via live cell counts, viability assays, and cell imaging. Our analysis of byproducts' chemical and physical properties revealed both structural and functional changes. Real-time high throughput analyses of exposed cellular systems confirmed that nanoclay induced significant toxic effects, with Cloisite 30B showing time-dependent decreases in live cell count and cellular viability relative to control and pristine nanoclay, respectively. Byproducts produced less toxic effects; all treatments caused alterations in the cell morphology upon exposure. Our morphological, behavioral, and viability cellular changes show that nanoclays have the potential to produce toxic effects when used both in manufacturing or disposal environments. The reported toxicological mechanisms prove the extensibility of a biosensorial-based platform for cellular behavior analysis upon treatment with a variety of nanomaterials. Copyright © 2016 Elsevier B.V. All rights reserved. JF - Biochimica et biophysica acta AU - Wagner, Alixandra AU - Eldawud, Reem AU - White, Andrew AU - Agarwal, Sushant AU - Stueckle, Todd A AU - Sierros, Konstantinos A AU - Rojanasakul, Yon AU - Gupta, Rakesh K AU - Dinu, Cerasela Zoica AD - Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV 26506, USA. ; National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. ; Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV 26506, USA. ; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA. ; Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV 26506, USA. Electronic address: rakesh.gupta@mail.wvu.edu. ; Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV 26506, USA. Electronic address: cerasela-zoica.dinu@mail.wvu.edu. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 3406 EP - 3415 VL - 1861 IS - 1 Pt A SN - 0006-3002, 0006-3002 KW - Thermal degradation KW - Lung cell KW - Montmorillonite KW - Toxicity KW - Nanoclay KW - Byproduct UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835665794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Toxicity+evaluations+of+nanoclays+and+thermally+degraded+byproducts+through+spectroscopical+and+microscopical+approaches.&rft.au=Wagner%2C+Alixandra%3BEldawud%2C+Reem%3BWhite%2C+Andrew%3BAgarwal%2C+Sushant%3BStueckle%2C+Todd+A%3BSierros%2C+Konstantinos+A%3BRojanasakul%2C+Yon%3BGupta%2C+Rakesh+K%3BDinu%2C+Cerasela+Zoica&rft.aulast=Wagner&rft.aufirst=Alixandra&rft.date=2017-01-01&rft.volume=1861&rft.issue=1+Pt+A&rft.spage=3406&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbagen.2016.09.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbagen.2016.09.003 ER - TY - JOUR T1 - Is It Adverse, Nonadverse, Adaptive, or Artifact? AN - 1835517625; 27770107 AB - One of the principal challenges facing a toxicologic pathologist is to determine and differentiate a true adverse effect from a nonadverse or an adaptive response. Recent publications from the Society of Toxicologic Pathology (STP) and the European STP provide guidance for determining and communicating adversity in nonclinical toxicology studies. In order to provide a forum to inform and engage in a discussion on this important topic, a continuing education (CE) course was held during the 2016 STP Annual meeting in San Diego, CA. The lectures at this course provided guidance on determining and communicating adversity using case studies involving both clinical pathology and anatomic pathology. In addition, one talk also focused on data quality, study design, and interpretation of artifacts that could hinder the determination of adversity. The CE course ended with a talk on understanding adversity in preclinical studies and engaging the regulatory agencies in the decision-making process. This manuscript is designed to provide brief summaries of all the talks in this well-received CE course. JF - Toxicologic pathology AU - Pandiri, Arun R AU - Kerlin, Roy L AU - Mann, Peter C AU - Everds, Nancy E AU - Sharma, Alok K AU - Myers, L Peyton AU - Steinbach, Thomas J AD - 1 National Toxicology Program, Research Triangle Park, North Carolina, USA. ; 2 Drug Safety Research and Development, Pfizer Inc., Groton, Connecticut, USA. ; 3 Experimental Pathology Laboratories, Inc., Northwest, Seattle, Washington, USA. ; 4 Amgen Inc., South San Francisco, California, USA. ; 5 Covance Laboratories, Madison, Wisconsin, USA. ; 6 U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ; 7 Experimental Pathology Laboratories, Inc., Durham, North Carolina, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 238 EP - 247 VL - 45 IS - 1 KW - nonadverse response KW - artifact KW - adversity KW - adaptive response UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835517625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Is+It+Adverse%2C+Nonadverse%2C+Adaptive%2C+or+Artifact%3F&rft.au=Pandiri%2C+Arun+R%3BKerlin%2C+Roy+L%3BMann%2C+Peter+C%3BEverds%2C+Nancy+E%3BSharma%2C+Alok+K%3BMyers%2C+L+Peyton%3BSteinbach%2C+Thomas+J&rft.aulast=Pandiri&rft.aufirst=Arun&rft.date=2017-01-01&rft.volume=45&rft.issue=1&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623316672352 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-22 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1177/0192623316672352 ER - TY - JOUR T1 - Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro™ - United States, 2013. AN - 1826710075; 27367536 AB - In September 2013, the Hawaii Department of Health (HDOH) was notified of seven adults who developed acute hepatitis after taking OxyELITE Pro™, a weight loss and sports dietary supplement. CDC assisted HDOH with their investigation, then conducted case-finding outside of Hawaii with FDA and the Department of Defense (DoD). We defined cases as acute hepatitis of unknown etiology that occurred from April 1, 2013, through December 5, 2013, following exposure to a weight loss or muscle-building dietary supplement, such as OxyELITE Pro™. We conducted case-finding through multiple sources, including data from poison centers (National Poison Data System [NPDS]) and FDA MedWatch. We identified 40 case-patients in 23 states and two military bases with acute hepatitis of unknown etiology and exposure to a weight loss or muscle building dietary supplement. Of 35 case-patients who reported their race, 15 (42.9%) reported white and 9 (25.7%) reported Asian. Commonly reported symptoms included jaundice, fatigue, and dark urine. Twenty-five (62.5%) case-patients reported taking OxyELITE Pro™. Of these 25 patients, 17 of 22 (77.3%) with available data were hospitalized and 1 received a liver transplant. NPDS and FDA MedWatch each captured seven (17.5%) case-patients. Improving the ability to search surveillance systems like NPDS and FDA MedWatch for individual and grouped dietary supplements, as well as coordinating case-finding with DoD, may benefit ongoing surveillance efforts and future outbreak responses involving adverse health effects from dietary supplements. This investigation highlights opportunities and challenges in using multiple sources to identify cases of suspected supplement associated adverse events. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Drug testing and analysis AU - Chatham-Stephens, Kevin AU - Taylor, Ethel AU - Chang, Arthur AU - Peterson, Amy AU - Daniel, Johnni AU - Martin, Colleen AU - Deuster, Patricia AU - Noe, Rebecca AU - Kieszak, Stephanie AU - Schier, Josh AU - Klontz, Karl AU - Lewis, Lauren AD - EIS officer, 1600 Clifton Road NE MS C-09, Atlanta, GA. ; Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention. ; Division of Integrated Biosurveillance, Armed Forces Health Surveillance Center. ; Department of Military and Emergency Medicine, Uniformed Services University. ; Office of Analytics and Outreach, Center for Food Safety and Applied Nutrition, Food and Drug Administration. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 68 EP - 74 VL - 9 IS - 1 KW - Supplement KW - OxyELITE Pro KW - hepatitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826710075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+testing+and+analysis&rft.atitle=Hepatotoxicity+associated+with+weight+loss+or+sports+dietary+supplements%2C+including+OxyELITE+Pro%E2%84%A2+-+United+States%2C+2013.&rft.au=Chatham-Stephens%2C+Kevin%3BTaylor%2C+Ethel%3BChang%2C+Arthur%3BPeterson%2C+Amy%3BDaniel%2C+Johnni%3BMartin%2C+Colleen%3BDeuster%2C+Patricia%3BNoe%2C+Rebecca%3BKieszak%2C+Stephanie%3BSchier%2C+Josh%3BKlontz%2C+Karl%3BLewis%2C+Lauren&rft.aulast=Chatham-Stephens&rft.aufirst=Kevin&rft.date=2017-01-01&rft.volume=9&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Drug+testing+and+analysis&rft.issn=1942-7611&rft_id=info:doi/10.1002%2Fdta.2036 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/dta.2036 ER - TY - JOUR T1 - Effects of titanium dioxide nanoparticles on human keratinocytes. AN - 1826702407; 27310834 AB - Titanium dioxide (TiO2) is a ubiquitous whitening compound widely used in topical products such as sunscreens, lotions and facial creams. The damaging health effects of TiO2 inhalation has been widely studied in rats, mice and humans showing oxidative stress increase, DNA damage, cell death and inflammatory gene upregulation in lung and throat cells; however, the effects on skin cells from long-term topical use of various products remain largely unknown. In this study, we assessed the effect of specific TiO2 nanoparticles (H2TiO7) on a human keratinocyte cell line (HaCaT). We performed a comparative analysis using three TiO2 particles varying in size (Fine, Ultrafine and H2TiO7) and analyzed their effects on HaCaTs. There is a clear dose-dependent increase in superoxide production, caspase 8 and 9 activity, and apoptosis in HaCaTs after treatment with all three forms of TiO2; however, there is no consistent effect on cell viability and proliferation with either of these TiO2 particles. While there is data suggesting UV exposure can enhance the carcinogenic effects of TiO2, we did not observe any significant effect of UV-C exposure combined with TiO2 treatment on HaCaTs. Furthermore, TiO2-treated cells showed minimal effects on VEGF upregulation and Wnt signaling pathway thereby showing no potential effect on angiogenesis and malignant transformation. Overall, we report here an increase in apoptosis, which may be caspase 8/Fas-dependent, and that the H2TiO7 nanoparticles, despite their smaller particle size, had no significant enhanced effect on HaCaT cells as compared to Fine and Ultrafine forms of TiO2. JF - Drug and chemical toxicology AU - Wright, Clayton AU - Iyer, Anand Krishnan V AU - Wang, Liying AU - Wu, Nianqiang AU - Yakisich, Juan S AU - Rojanasakul, Yon AU - Azad, Neelam AD - a Department of Pharmaceutical Sciences , Hampton University , Hampton , VA , USA. ; b Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health , Morgantown , WV , USA. ; c Department of Mechanical & Aerospace Engineering , and. ; d Department of Pharmaceutical and Pharmacological Sciences , West Virginia University , Morgantown , WV , USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 90 EP - 100 VL - 40 IS - 1 KW - keratinocytes KW - Titanium dioxide KW - apoptosis KW - reactive oxygen species KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826702407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=Effects+of+titanium+dioxide+nanoparticles+on+human+keratinocytes.&rft.au=Wright%2C+Clayton%3BIyer%2C+Anand+Krishnan+V%3BWang%2C+Liying%3BWu%2C+Nianqiang%3BYakisich%2C+Juan+S%3BRojanasakul%2C+Yon%3BAzad%2C+Neelam&rft.aulast=Wright&rft.aufirst=Clayton&rft.date=2017-01-01&rft.volume=40&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=1525-6014&rft_id=info:doi/10.1080%2F01480545.2016.1185111 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-16 N1 - Date revised - 2017-02-02 N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1080/01480545.2016.1185111 ER - TY - JOUR T1 - FDA-approved drugs that interfere with laboratory tests: A systematic search of US drug labels. AN - 1826683247; 27193822 AB - Drug-related laboratory test interference or drug/laboratory test interactions (DLTI) are a major source of laboratory errors. DLTI is of concern with regard to both the clinical diagnosis and the monitoring of patients. Although there have been numerous reports about specific drugs that interfere with laboratory tests, there has not been a recent review on the topic. We herein provide a review of the known DLTI of US FDA-approved drugs based on a systematic search of DailyMed, a website containing the labels of US FDA-approved drugs. The labels for all human single-ingredient prescription drugs included in the database (1368) were searched using stemmed keywords and were manually reviewed for their relevance to DLTI. A total of 134 labels were positive, which indicated that the drug interferes with at least one clinical laboratory test. Antibacterial agents, psychotropic drugs and contrast media are the classes of drugs most likely to lead to DLTI. Urine was the clinical sample most frequently affected by DLTI. The FDA drug label is a source of information for studies of DLTI, although information is still lacking for most drugs, and additional improvements are needed for many of the existing records. Medical professionals, clinicians and laboratory staff should keep these possible interactions in mind when interpreting the results of laboratory tests, and should ensure that they obtain a complete and accurate record of all drugs being used by patients in order to anticipate potential DLTI. The development of a reporting system to address potential DLTI is warranted. JF - Critical reviews in clinical laboratory sciences AU - Yao, Hui AU - Rayburn, Elizabeth R AU - Shi, Qiang AU - Gao, Liang AU - Hu, Wenjie AU - Li, Haibo AD - a Department of Clinical Laboratory Medicine , Nantong Maternity and Child Health Hospital , Nantong , P.R. China. ; b CLIA Laboratory Director (various laboratories) , Birmingham , AL , USA , and. ; c Division of Systems Biology , National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson , AR , USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1 EP - 17 VL - 54 IS - 1 KW - DailyMed KW - prescription drugs KW - Drug-related laboratory test interference KW - FDA labels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826683247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+clinical+laboratory+sciences&rft.atitle=FDA-approved+drugs+that+interfere+with+laboratory+tests%3A+A+systematic+search+of+US+drug+labels.&rft.au=Yao%2C+Hui%3BRayburn%2C+Elizabeth+R%3BShi%2C+Qiang%3BGao%2C+Liang%3BHu%2C+Wenjie%3BLi%2C+Haibo&rft.aulast=Yao&rft.aufirst=Hui&rft.date=2017-01-01&rft.volume=54&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+clinical+laboratory+sciences&rft.issn=1549-781X&rft_id=info:doi/10.1080%2F10408363.2016.1191425 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-27 N1 - Date revised - 2017-01-30 N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1080/10408363.2016.1191425 ER - TY - JOUR T1 - Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas. AN - 1854104478; 28029918 AB - Background Effective medical therapies are lacking for the treatment of neurofibromatosis type 1-related plexiform neurofibromas, which are characterized by elevated RAS-mitogen-activated protein kinase (MAPK) signaling. Methods We conducted a phase 1 trial of selumetinib (AZD6244 or ARRY-142886), an oral selective inhibitor of MAPK kinase (MEK) 1 and 2, in children who had neurofibromatosis type 1 and inoperable plexiform neurofibromas to determine the maximum tolerated dose and to evaluate plasma pharmacokinetics. Selumetinib was administered twice daily at a dose of 20 to 30 mg per square meter of body-surface area on a continuous dosing schedule (in 28-day cycles). We also tested selumetinib using a mouse model of neurofibromatosis type 1-related neurofibroma. Response to treatment (i.e., an increase or decrease from baseline in the volume of plexiform neurofibromas) was monitored by using volumetric magnetic resonance imaging analysis to measure the change in size of the plexiform neurofibroma. Results A total of 24 children (median age, 10.9 years; range, 3.0 to 18.5) with a median tumor volume of 1205 ml (range, 29 to 8744) received selumetinib. Patients were able to receive selumetinib on a long-term basis; the median number of cycles was 30 (range, 6 to 56). The maximum tolerated dose was 25 mg per square meter (approximately 60% of the recommended adult dose). The most common toxic effects associated with selumetinib included acneiform rash, gastrointestinal effects, and asymptomatic creatine kinase elevation. The results of pharmacokinetic evaluations of selumetinib among the children in this trial were similar to those published for adults. Treatment with selumetinib resulted in confirmed partial responses (tumor volume decreases from baseline of ≥20%) in 17 of the 24 children (71%) and decreases from baseline in neurofibroma volume in 12 of 18 mice (67%). Disease progression (tumor volume increase from baseline of ≥20%) has not been observed to date. Anecdotal evidence of decreases in tumor-related pain, disfigurement, and functional impairment was observed. Conclusions Our early-phase data suggested that children with neurofibromatosis type 1 and inoperable plexiform neurofibromas benefited from long-term dose-adjusted treatment with selumetinib without having excess toxic effects. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT01362803 .). JF - The New England journal of medicine AU - Dombi, Eva AU - Baldwin, Andrea AU - Marcus, Leigh J AU - Fisher, Michael J AU - Weiss, Brian AU - Kim, AeRang AU - Whitcomb, Patricia AU - Martin, Staci AU - Aschbacher-Smith, Lindsey E AU - Rizvi, Tilat A AU - Wu, Jianqiang AU - Ershler, Rachel AU - Wolters, Pamela AU - Therrien, Janet AU - Glod, John AU - Belasco, Jean B AU - Schorry, Elizabeth AU - Brofferio, Alessandra AU - Starosta, Amy J AU - Gillespie, Andrea AU - Doyle, Austin L AU - Ratner, Nancy AU - Widemann, Brigitte C AD - From the Center for Cancer Research, Pediatric Oncology Branch, Bethesda (E.D., A. Baldwin, L.J.M., P. Whitcomb, S.M., R.E., P. Wolters, J.T., J.G., A.J.S., A.G., B.C.W.) and the Cancer Therapy Evaluation Program, Shady Grove (A.L.D.), National Cancer Institute, and the National Heart, Lung, and Blood Institute (A. Brofferio), Bethesda, National Institutes of Health, and the Food and Drug Administration, Silver Spring (L.J.M., R.E.) - all in Maryland; the Division of Oncology, Children's Hospital of Philadelphia, and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (M.J.F., J.B.B.); Children's National Health System, Washington, DC (A.K.); and Cincinnati Children's Hospital, Cincinnati (B.W., L.E.A.-S., T.A.R., J.W., E.S., N.R.). Y1 - 2016/12/29/ PY - 2016 DA - 2016 Dec 29 SP - 2550 EP - 2560 VL - 375 IS - 26 KW - AZD 6244 KW - 0 KW - Benzimidazoles KW - Protein Kinase Inhibitors KW - Mitogen-Activated Protein Kinase Kinases KW - EC 2.7.12.2 KW - Abridged Index Medicus KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Humans KW - Disease Progression KW - Disease Models, Animal KW - Mice KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Neurofibromatosis 1 -- drug therapy KW - Protein Kinase Inhibitors -- adverse effects KW - Neurofibroma, Plexiform -- drug therapy KW - Benzimidazoles -- adverse effects KW - Benzimidazoles -- administration & dosage KW - Protein Kinase Inhibitors -- administration & dosage KW - Protein Kinase Inhibitors -- pharmacokinetics KW - Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors KW - Benzimidazoles -- pharmacokinetics KW - Neurofibroma, Plexiform -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1854104478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Activity+of+Selumetinib+in+Neurofibromatosis+Type+1-Related+Plexiform+Neurofibromas.&rft.au=Dombi%2C+Eva%3BBaldwin%2C+Andrea%3BMarcus%2C+Leigh+J%3BFisher%2C+Michael+J%3BWeiss%2C+Brian%3BKim%2C+AeRang%3BWhitcomb%2C+Patricia%3BMartin%2C+Staci%3BAschbacher-Smith%2C+Lindsey+E%3BRizvi%2C+Tilat+A%3BWu%2C+Jianqiang%3BErshler%2C+Rachel%3BWolters%2C+Pamela%3BTherrien%2C+Janet%3BGlod%2C+John%3BBelasco%2C+Jean+B%3BSchorry%2C+Elizabeth%3BBrofferio%2C+Alessandra%3BStarosta%2C+Amy+J%3BGillespie%2C+Andrea%3BDoyle%2C+Austin+L%3BRatner%2C+Nancy%3BWidemann%2C+Brigitte+C&rft.aulast=Dombi&rft.aufirst=Eva&rft.date=2016-12-29&rft.volume=375&rft.issue=26&rft.spage=2550&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMoa1605943 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-10 N1 - Date created - 2016-12-28 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT01362803; ClinicalTrials.gov N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMoa1605943 ER - TY - JOUR T1 - Organ-specific epigenetic changes induced by the non-genotoxic liver carcinogen methapyrilene in Fischer 344 rats. AN - 1859755119; 28013212 AB - Continuous lifetime exposure to certain natural and man-made chemicals is a major cause of cancers in humans; therefore, evaluating the carcinogenic risks of chemicals remains important. Currently, substantial progress has been made in identification of genotoxic carcinogens; in contrast, predicting a carcinogenic potential of non-genotoxic compounds is a challenge due to many different modes of action that may lead to tumorigenesis. In the present study, we investigated the effects of the non-genotoxic liver carcinogen methapyrilene and the nongenotoxic non-carcinogen usnic acid at doses that do not exhibit organ cytotoxicity on epigenomic alterations in the liver and kidneys of Fischer 344 (F344) rats. We demonstrate that the repeatdose oral treatment of male F344 rats with methapyrilene for six weeks caused target organspecific epigenetic alterations in the livers. In contrast, slight or no epigenetic changes were found in the livers of F344 rats treated with hepatotoxicant, but non-carcinogen, usnic acid. Themetahpyrilene-induced epigenetic changes consisted of changes in histone lysine acetylation and methylation, with the greatest decrease being in global and gene-specific histone H3 lysine 9 (H3K9) acetylation. Importantly, the results of the present study show an association between gene-specific histone H3K9 deacetylation and a reduced expression of critical cancer-related genes, including prospero homeobox 1 (Prox1), HNF1 homebox A (Hnf1a), and peroxisome proliferator activated receptor alpha (Ppara), which provides a mechanistic link between methapyrilene-induced epigenetic aberrations and liver carcinogenesis. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Shpyleva, Svitlana AU - Dreval, Kostiantyn AU - de Conti, Aline AU - Kindrat, Iryna AU - Melnyk, Stepan AU - Yan, Jian AU - Chen, Tao AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, 72079, USA. ; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72202. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, 72079, USA. Y1 - 2016/12/24/ PY - 2016 DA - 2016 Dec 24 KW - non-genotoxic carcinogens KW - epigenetics KW - liver KW - methapyrilene UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859755119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Organ-specific+epigenetic+changes+induced+by+the+non-genotoxic+liver+carcinogen+methapyrilene+in+Fischer+344+rats.&rft.au=Shpyleva%2C+Svitlana%3BDreval%2C+Kostiantyn%3Bde+Conti%2C+Aline%3BKindrat%2C+Iryna%3BMelnyk%2C+Stepan%3BYan%2C+Jian%3BChen%2C+Tao%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Shpyleva&rft.aufirst=Svitlana&rft.date=2016-12-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw242 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw242 ER - TY - JOUR T1 - Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials. AN - 1852780909; 28009471 AB - As a widely used nanomaterial in daily life, silver nanomaterials may cause great concern to female reproductive system as they are found to penetrate the blood-placental barrier and gain access to the ovary. However, it is largely unknown about how silver nanomaterials influence ovarian physiology and functions such as hormone production. This study performs in vitro toxicology study of silver nanomaterials, focusing especially on cytotoxicity and steroidogenesis and explores their underlying mechanisms. This study exposes primary rat granulosa cells to gold nanorod core/silver shell nanostructures (Au@Ag NRs), and compares outcomes with cells exposed to gold nanorods. The Au@Ag NRs generate more reactive oxygen species and reduce mitochondrial membrane potential and less production of adenosine triphosphate. Au@Ag NRs promote steroidogenesis, including progesterone and estradiol, in a time- and dose-dependent manner. Chemical reactivity and transformation of Au@Ag NRs are then studied by electron spin resonance spectroscopy and X-ray absorption near edge structure, which analyze the generation of free radical and intracellular silver species. Results suggest that both particle-specific activity and intracellular silver ion release of Au@Ag NR contribute to the toxic response of granulosa cells. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. JF - Small (Weinheim an der Bergstrasse, Germany) AU - Jiang, Xiumei AU - Wang, Liming AU - Ji, Yinglu AU - Tang, Jinglong AU - Tian, Xin AU - Cao, Mingjing AU - Li, Jingxuan AU - Bi, Shuying AU - Wu, Xiaochun AU - Chen, Chunying AU - Yin, Jun-Jie AD - CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Ambient Particles Health Effects and Prevention Techniques, National Center for Nanoscience and Technology and Institute of High Energy Physics, Beijing, 100190, China. ; CAS Key Laboratory of Standardization and Measurement for Nanotechnology and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, 20740, USA. ; The General Hospital of the Air Force, PLA, Beijing, 100142, China. Y1 - 2016/12/23/ PY - 2016 DA - 2016 Dec 23 KW - silver nanomaterials KW - cell apoptosis KW - electron spin resonance KW - Au@Ag NRs KW - steroidogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852780909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Small+%28Weinheim+an+der+Bergstrasse%2C+Germany%29&rft.atitle=Interference+of+Steroidogenesis+by+Gold+Nanorod+Core%2FSilver+Shell+Nanostructures%3A+Implications+for+Reproductive+Toxicity+of+Silver+Nanomaterials.&rft.au=Jiang%2C+Xiumei%3BWang%2C+Liming%3BJi%2C+Yinglu%3BTang%2C+Jinglong%3BTian%2C+Xin%3BCao%2C+Mingjing%3BLi%2C+Jingxuan%3BBi%2C+Shuying%3BWu%2C+Xiaochun%3BChen%2C+Chunying%3BYin%2C+Jun-Jie&rft.aulast=Jiang&rft.aufirst=Xiumei&rft.date=2016-12-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Small+%28Weinheim+an+der+Bergstrasse%2C+Germany%29&rft.issn=1613-6829&rft_id=info:doi/10.1002%2Fsmll.201602855 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/smll.201602855 ER - TY - JOUR T1 - Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of U.S. Commercial Cigarettes. AN - 1851693625; 28001416 AB - Tobacco-specific nitrosamines (TSNAs) are N-nitroso-derivatives of pyridine-alkaloids (e.g., nicotine) present in tobacco and cigarette smoke. Two TSNAs, N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), are included on the Food and Drug Administration's list of harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco. The amounts of four TSNAs (NNK, NNN, N-nitrosoanabasine (NAB), and N'-nitrosoanatabine (NAT)) in the tobacco and mainstream smoke from 50 U.S. commercial cigarette brands were measured from November 15, 2011 to January 4, 2012 using a validated HPLC/MS/MS method. Smoke samples were generated using the International Organization of Standardization (ISO) and Canadian Intense (CI) machine-smoking regimens. NNN and NAT were the most abundant TSNAs in tobacco filler and smoke across all cigarette brands, whereas NNK and NAB were present in lesser amounts. The average ratios for each TSNA in mainstream smoke to filler content is 29% by the CI smoking regimen and 13% for the ISO machine-smoking regimen. The reliability of individual TSNAs to predict total TSNA amounts in the filler and smoke was examined. NNN, NAT, and NAB have a moderate to high correlation (R2 = 0.61-0.98, p < 0.0001), and all three TSNAs individually predict total TSNAs with minimal difference between measured and predicted total TSNA amounts (error < 7.4%). NNK has weaker correlation (R2 = 0.56-0.82; p < 0.0001) and is a less reliable predictor of total TSNA quantities. Tobacco weight and levels of TSNAs in filler influence TSNA levels in smoke from the CI machine-smoking regimen. In contrast, filter ventilation is a major determinant of levels of TSNAs in smoke by the ISO machine-smoking regimen. Comparative analysis demonstrates substantial variability in TSNA amounts in tobacco filler and mainstream smoke yields under ISO and CI machine-smoking regimens among U.S. commercial cigarette brands. JF - Chemical research in toxicology AU - Edwards, Selvin H AU - Rossiter, Lana M AU - Taylor, Kenneth M AU - Holman, Matthew R AU - Zhang, Liqin AU - Ding, Yan S AU - Watson, Clifford H AD - Center for Tobacco Products, Food and Drug Administration , Silver Spring, Maryland 20850, United States. ; Centers for Disease Control and Prevention, National Center for Environmental Health , Atlanta, Georgia 30341, United States. Y1 - 2016/12/21/ PY - 2016 DA - 2016 Dec 21 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851693625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Tobacco-Specific+Nitrosamines+in+the+Tobacco+and+Mainstream+Smoke+of+U.S.+Commercial+Cigarettes.&rft.au=Edwards%2C+Selvin+H%3BRossiter%2C+Lana+M%3BTaylor%2C+Kenneth+M%3BHolman%2C+Matthew+R%3BZhang%2C+Liqin%3BDing%2C+Yan+S%3BWatson%2C+Clifford+H&rft.aulast=Edwards&rft.aufirst=Selvin&rft.date=2016-12-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00268 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00268 ER - TY - JOUR T1 - Update on dietary intake of perchlorate and iodine from U.S. food and drug administration's total diet study: 2008-2012. AN - 1851295760; 28000685 AB - The U.S. Food and Drug Administration's (FDA) Total Diet Study (TDS) monitors the US food supply for pesticide residues, industrial chemicals, radionuclides, nutrients, and toxic elements. Perchlorate and iodine intakes based on concentrations in TDS samples collected between 2008 and 2012 were estimated in order to update an earlier TDS dietary assessment. Perchlorate is used as an oxidizing agent in rocket and missile fuel, is formed naturally in the atmosphere, and occurs naturally in some soils. Because of perchlorate's presence in soil, and in irrigation, processing, and source water, it is widely found in food. Iodine was included in the study because perchlorate at high doses interferes with iodide uptake in the thyroid. Iodine (the elemental form of iodide) is essential for growth and development, and metabolism. This study uses a novel statistical method based on a clustered zero-inflated lognormal distribution model to estimate mean and 95th percentile confidence interval concentrations for perchlorate and iodine in US foods. These estimates were used to estimate mean perchlorate and iodine exposures for the total US population and for 14 age/sex groups in the US population. Estimated mean perchlorate intake for the total US population was 0.13 μg/kg bw/day, with mean intakes for the 14 age/sex groups between 0.09 and 0.43 μg/kg bw/day. The estimated mean intakes of perchlorate for all age/sex groups were below EPA's reference dose (RfD) of 0.7 μg/kg bw/day. The estimated mean iodine intake for the total US population was 216.4 μg/person/day, with mean intakes ranging from 140.9 to 296.3 μg/person/day for the 14 age/sex groups, with all age/sex groups exceeding their respective estimated average requirements (EARs).Journal of Exposure Science and Environmental Epidemiology advance online publication, 21 December 2016; doi:10.1038/jes.2016.78. JF - Journal of exposure science & environmental epidemiology AU - Abt, Eileen AU - Spungen, Judith AU - Pouillot, Régis AU - Gamalo-Siebers, Margaret AU - Wirtz, Mark AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, MD, USA. Y1 - 2016/12/21/ PY - 2016 DA - 2016 Dec 21 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851295760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Update+on+dietary+intake+of+perchlorate+and+iodine+from+U.S.+food+and+drug+administration%27s+total+diet+study%3A+2008-2012.&rft.au=Abt%2C+Eileen%3BSpungen%2C+Judith%3BPouillot%2C+R%C3%A9gis%3BGamalo-Siebers%2C+Margaret%3BWirtz%2C+Mark&rft.aulast=Abt&rft.aufirst=Eileen&rft.date=2016-12-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2016.78 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jes.2016.78 ER - TY - JOUR T1 - Induction of cancer-associated fibroblast-like cells by carbon nanotubes dictates its tumorigenicity. AN - 1851299037; 27996035 AB - Tumor microenvironment has been recognized as a key determinant of tumor formation and metastasis, but how tumor microenvironment is affected by nanomaterials is essentially unknown. Here, we investigated whether carbon nanotubes (CNTs), a widely used nanomaterial with known carcinogenic potential, can affect cancer-associated fibroblasts (CAFs), which are a key component of tumor microenvironment that provides necessary support for tumor growth. We show for the first time that single-walled CNT and to a lesser extent multi-walled and its COOH-functionalized form induced CAF-like cells, which are non-tumorigenic in animals, but promote tumor growth of human lung carcinoma and CNT-transformed lung epithelial cells. The mechanism by which CNT-induced CAF-like cells promote tumor growth involved the acquisition of cancer stem cells (CSCs) in cancer population. Gene knockdown experiments showed that an expression of podoplanin on CAF-like cells is essential for their effects, indicating the functional role of CAF-like cells and podoplanin in CNT tumorigenic process. Our findings unveil a novel mechanism of CNT-induced carcinogenesis through the induction of CAF-like cells that support CSCs and drive tumor formation. Our results also suggest the potential utility of podoplanin as a mechanism-based biomarker for rapid screening of carcinogenicity of CNTs and related nanomaterials for their safer design. JF - Scientific reports AU - Luanpitpong, Sudjit AU - Wang, Liying AU - Castranova, Vincent AU - Dinu, Cerasela Zoica AU - Issaragrisil, Surapol AU - Chen, Yi Charlie AU - Rojanasakul, Yon AD - Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. ; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. ; Pharmaceutical and Pharmacological Sciences Program, West Virginia University, WV 26506, USA. ; Department of Chemical Engineering, West Virginia University, WV 26506, USA. ; Natural Science Division, Alderson Broaddus University, Philippi, WV 26416, USA. Y1 - 2016/12/20/ PY - 2016 DA - 2016 Dec 20 SP - 39558 VL - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851299037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Induction+of+cancer-associated+fibroblast-like+cells+by+carbon+nanotubes+dictates+its+tumorigenicity.&rft.au=Luanpitpong%2C+Sudjit%3BWang%2C+Liying%3BCastranova%2C+Vincent%3BDinu%2C+Cerasela+Zoica%3BIssaragrisil%2C+Surapol%3BChen%2C+Yi+Charlie%3BRojanasakul%2C+Yon&rft.aulast=Luanpitpong&rft.aufirst=Sudjit&rft.date=2016-12-20&rft.volume=6&rft.issue=&rft.spage=39558&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep39558 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep39558 ER - TY - JOUR T1 - New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan. AN - 1839121858; 27825936 AB - Furan is a rodent hepatocarcinogen ubiquitously found in the environment and heat-processed foods. Furan undergoes cytochrome P450 2E1-catalyzed bioactivation to cis-2-butene-1,4-dial (BDA), which has been shown to form an electrophilic conjugate (GSH-BDA) with glutathione. Both BDA and GSH-BDA yield covalent adducts with lysine residues in proteins. Dose- and time-dependent epigenetic histone alterations have been observed in furan-treated rats. While the covalent modification of histones by chemical carcinogens has long been proposed, histone-carcinogen adducts have eluded detection in vivo. In this study, we investigated if the covalent modification of histones by furan may occur in vivo prior to epigenetic histone alterations. Using a "bottom-up" methodology, involving the analysis of tryptic peptides by liquid chromatography - high resolution mass spectrometry, we obtained evidence for a cross-link between GSH-BDA and lysine 107 of histone H2B isolated from the livers of male F344 rats treated with tumorigenic doses of furan. This cross-link was detected at the shortest treatment period (90 days) in the lowest dose group (0.92mg/kg body weight/day), prior to the identification of epigenetic changes, and occurred at a lysine residue that is a target for epigenetic modifications and crucial for nucleosome stability. Our results represent the first unequivocal proof of the occurrence of carcinogen-modified histones in vivo and suggest that such modification happens at the initial stages of furan-induced carcinogenesis. This type of alteration may be general in scope, opening new insights into the mechanisms of chemical carcinogenesis/toxicity and new opportunities for the development of early compound-specific biomarkers of exposure. JF - Toxicology letters AU - Nunes, João AU - Martins, Inês L AU - Charneira, Catarina AU - Pogribny, Igor P AU - de Conti, Aline AU - Beland, Frederick A AU - Marques, M Matilde AU - Jacob, Cristina C AU - Antunes, Alexandra M M AD - Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal. Electronic address: alexandra.antunes@tecnico.ulisboa.pt. Y1 - 2016/12/15/ PY - 2016 DA - 2016 Dec 15 SP - 106 EP - 113 VL - 264 KW - Carcinogens KW - 0 KW - Furans KW - Histones KW - Peptides KW - Trypsin KW - EC 3.4.21.4 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Histone adducts KW - Furan KW - Biomarkers KW - Chemically induced cancers KW - Trypsin -- chemistry KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Carcinogenicity Tests KW - Peptides -- chemistry KW - Liver -- metabolism KW - Glutathione -- chemistry KW - Liver -- chemistry KW - Male KW - Furans -- metabolism KW - Furans -- toxicity KW - Carcinogens -- toxicity KW - Carcinogenesis -- drug effects KW - Histones -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1839121858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=New+insights+into+the+molecular+mechanisms+of+chemical+carcinogenesis%3A+In+vivo+adduction+of+histone+H2B+by+a+reactive+metabolite+of+the+chemical+carcinogen+furan.&rft.au=Nunes%2C+Jo%C3%A3o%3BMartins%2C+In%C3%AAs+L%3BCharneira%2C+Catarina%3BPogribny%2C+Igor+P%3Bde+Conti%2C+Aline%3BBeland%2C+Frederick+A%3BMarques%2C+M+Matilde%3BJacob%2C+Cristina+C%3BAntunes%2C+Alexandra+M+M&rft.aulast=Nunes&rft.aufirst=Jo%C3%A3o&rft.date=2016-12-15&rft.volume=264&rft.issue=&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2016.10.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-02 N1 - Date created - 2016-11-09 N1 - Date revised - 2017-02-07 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1016/j.toxlet.2016.10.018 ER - TY - JOUR T1 - Simple and rapid quantification of brominated vegetable oil in commercial soft drinks by LC-MS. AN - 1807080194; 27451219 AB - We report here a simple and rapid method for the quantification of brominated vegetable oil (BVO) in soft drinks based upon liquid chromatography-electrospray ionization mass spectrometry. Unlike previously reported methods, this novel method does not require hydrolysis, extraction or derivatization steps, but rather a simple "dilute and shoot" sample preparation. The quantification is conducted by mass spectrometry in selected ion recording mode and a single point standard addition procedure. The method was validated in the range of 5-25μg/mL BVO, encompassing the legal limit of 15μg/mL established by the US FDA for fruit-flavored beverages in the US market. The method was characterized by excellent intra- and inter-assay accuracy (97.3-103.4%) and very low imprecision [0.5-3.6% (RSD)]. The direct nature of the quantification, simplicity, and excellent statistical performance of this methodology constitute clear advantages in relation to previously published methods for the analysis of BVO in soft drinks. JF - Food chemistry AU - Chitranshi, Priyanka AU - Gamboa da Costa, Gonçalo AD - Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: goncalo.gamboa@fda.hhs.gov. Y1 - 2016/12/15/ PY - 2016 DA - 2016 Dec 15 SP - 567 EP - 570 VL - 213 SN - 0308-8146, 0308-8146 KW - Plant Oils KW - 0 KW - Index Medicus KW - BVO KW - Brominated vegetable oil KW - Method validation KW - LC–MS KW - Soft drinks KW - Halogenation KW - Carbonated Beverages -- analysis KW - Chromatography, Liquid -- methods KW - Beverages -- analysis KW - Plant Oils -- chemistry KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807080194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+chemistry&rft.atitle=Simple+and+rapid+quantification+of+brominated+vegetable+oil+in+commercial+soft+drinks+by+LC-MS.&rft.au=Chitranshi%2C+Priyanka%3BGamboa+da+Costa%2C+Gon%C3%A7alo&rft.aulast=Chitranshi&rft.aufirst=Priyanka&rft.date=2016-12-15&rft.volume=213&rft.issue=&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Food+chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2016.06.110 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-09 N1 - Date created - 2016-07-25 N1 - Date revised - 2017-02-13 N1 - Last updated - 2017-02-13 DO - http://dx.doi.org/10.1016/j.foodchem.2016.06.110 ER - TY - JOUR T1 - Extraction and Liquid Chromatography-Tandem Mass Spectrometry Detection of 3-Monochloropropanediol Esters and Glycidyl Esters in Infant Formula. AN - 1851285226; 27960288 AB - A method was developed for the extraction of fatty acid esters of 3-chloro-1,2-propanediol (3-MCPD) and glycidol from infant formula, followed by quantitative analysis of the extracts using liquid chromatography-tandem mass spectrometry (LC-MS/MS). These process-induced chemical contaminants are found in refined vegetable oils, and studies have shown that they are potentially carcinogenic and/or genotoxic, making their presence in edible oils (and processed foods containing these oils) a potential health risk. The extraction procedure involves a liquid-liquid extraction, where powdered infant formula is dissolved in water and extracted with ethyl acetate. Following shaking, centrifugation, and drying of the organic phase, the resulting fat extract is cleaned-up using solid-phase extraction and analyzed by LC-MS/MS. Method performance was confirmed by verifying the percent recovery of each 3-MCPD and glycidyl ester in a homemade powdered infant formula reference material. Average ester recoveries in the reference material ranged from 84.9 to 109.0% (0.6-9.5% RSD). The method was also validated by fortifying three varieties of commercial infant formulas with a 3-MCPD and glycidyl ester solution. Average recoveries of the esters across all concentrations and varieties of infant formula ranged from 88.7 to 107.5% (1.0-9.5% RSD). Based on the validation results, this method is suitable for producing 3-MCPD and glycidyl ester occurrence data in all commercially available varieties of infant formula. JF - Journal of agricultural and food chemistry AU - Leigh, Jessica K AU - MacMahon, Shaun AD - Center for Food Safety and Applied Nutrition, United States Food and Drug Administration , 5001 Campus Drive, College Park, Maryland 20740, United States. Y1 - 2016/12/14/ PY - 2016 DA - 2016 Dec 14 SP - 9442 EP - 9451 VL - 64 IS - 49 KW - glycidyl esters KW - 3-MCPD KW - fat extraction KW - processing contaminants KW - glycidol KW - 3-MCPD esters KW - infant formula KW - 3-monochloropropanediol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851285226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Extraction+and+Liquid+Chromatography-Tandem+Mass+Spectrometry+Detection+of+3-Monochloropropanediol+Esters+and+Glycidyl+Esters+in+Infant+Formula.&rft.au=Wang%2C+Hua%3BGill%2C+Vikas+S%3BCheng%2C+Chorng-Ming%3BGonzalez-Escalona%2C+Narjol%3BIrvin%2C+Kari+A%3BZheng%2C+Jie%3BBell%2C+Rebecca+L%3BJacobson%2C+Andrew+P%3BHammack%2C+Thomas+S&rft.aulast=Wang&rft.aufirst=Hua&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.06.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Battle in the New World: Helicoverpa armigera versus Helicoverpa zea (Lepidoptera: Noctuidae) AN - 1868339826; PQ0003937321 AB - The corn earworm Helicoverpa zea (Boddie) and the old world bollworm Helicoverpa armigera (Huebner) (Lepidoptera: Noctuidae) are allopatric species and occur in important agricultural crops. In maize, both species tend to infest the ear. The introduction of H. armigera in Brazil has created a new scenario, where these Helicoverpa species might cohabit and interact with one another, affecting the prevalence of each species in the agroecosystem, integrated pest management, and insect resistance management. In this study, larval occurrence and proportion of these species in maize was assessed in three regions of Brazil during three crop seasons. Interaction between the species was evaluated in interspecific and intraspecific scenarios under laboratory and field conditions. Helicoverpa zea was predominant in Rio Grande do Sul and the Planaltina, DF (central Brazil). In western Bahia, H. zea was predominant in the first collection, but approximately equal in number to H armigera in the second crop season. Both species exhibit high cannibalism/predation rates, and larval size was the primary factor for larval survival in the interaction studies. Larva of H. zea had higher survival when interacting with H. armigera, indicating that H. zea has an advantage in intraguild interactions with H. armigera in maize. Overall, the results from this study indicate that maize might play a role as a source of infestation or a sink of insecticide or Bt protein unselected H. armigera populations, depending on the H. zea:H. armigera intraguild competition and adult movement in the landscape. JF - PLoS ONE AU - Bentivenha, Jose PF AU - Paula-Moraes, Silvana V AU - Baldin, Edson LL AU - Specht, Alexandre AU - Silva, Ivana Fda AU - Hunt, Thomas E Y1 - 2016/12// PY - 2016 DA - December 2016 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 11 IS - 12 KW - Entomology Abstracts; Biotechnology and Bioengineering Abstracts KW - Helicoverpa armigera KW - Laboratories KW - Predation KW - Cannibalism KW - Larvae KW - Survival KW - Helicoverpa zea KW - Pest control KW - Crops KW - Lepidoptera KW - Interspecific KW - Infestation KW - Insecticides KW - Zea mays KW - Noctuidae KW - Competition KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - W 30930:Agricultural Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868339826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Battle+in+the+New+World%3A+Helicoverpa+armigera+versus+Helicoverpa+zea+%28Lepidoptera%3A+Noctuidae%29&rft.au=Bentivenha%2C+Jose+PF%3BPaula-Moraes%2C+Silvana+V%3BBaldin%2C+Edson+LL%3BSpecht%2C+Alexandre%3BSilva%2C+Ivana+Fda%3BHunt%2C+Thomas+E&rft.aulast=Bentivenha&rft.aufirst=Jose&rft.date=2016-12-01&rft.volume=11&rft.issue=12&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0167182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Interspecific; Infestation; Insecticides; Laboratories; Predation; Larvae; Cannibalism; Survival; Pest control; Competition; Crops; Helicoverpa armigera; Zea mays; Helicoverpa zea; Noctuidae; Lepidoptera DO - http://dx.doi.org/10.1371/journal.pone.0167182 ER - TY - JOUR T1 - Smoking status, usual adult occupation, and risk of recurrent urothelial bladder carcinoma: data from The Cancer Genome Atlas (TCGA) Project AN - 1868337768; PQ0004057584 AB - Tobacco smoking and occupational exposures are the leading risk factors for developing urothelial bladder carcinoma (UBC), yet little is known about the contribution of these two factors to risk of UBC recurrence. We evaluated whether smoking status and usual adult occupation are associated with time to UBC recurrence for 406 patients with muscle-invasive bladder cancer submitted to The Cancer Genome Atlas (TCGA) project. Kaplan-Meier and Cox proportional hazard methods were used to assess the association between smoking status, employment in a high-risk occupation for bladder cancer, occupational diesel exhaust exposure, and 2010 Standard Occupational Classification group and time to UBC recurrence. Data on time to recurrence were available for 358 patients over a median follow-up time of 15 months. Of these, 133 (37.2%) experienced a recurrence. Current smokers who smoked for more than 40 pack-years had an increased risk of recurrence compared to never smokers (HR 2.1, 95% CI 1.1, 4.1). Additionally, employment in a high-risk occupation was associated with a shorter time to recurrence (log-rank p = 0.005). We found an increased risk of recurrence for those employed in occupations with probable diesel exhaust exposure (HR 1.8, 95% CI 1.1, 3.0) and for those employed in production occupations (HR 2.0, 95% CI 1.1, 3.6). These findings suggest smoking status impacts risk of UBC recurrence, although several previous studies provided equivocal evidence regarding this association. In addition to the known causal relationship between occupational exposure and bladder cancer risk, our study suggests that occupation may also be related to increased risk of recurrence. JF - Cancer Causes & Control AU - Wilcox, Amber N AU - Silverman, Debra T AU - Friesen, Melissa C AU - Locke, Sarah J AU - Russ, Daniel E AU - Hyun, Noorie AU - Colt, Joanne S AU - Figueroa, Jonine D AU - Rothman, Nathaniel AU - Moore, Lee E AU - Koutros, Stella AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, MD, USA, koutross@mail.nih.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1429 EP - 1435 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 27 IS - 12 SN - 0957-5243, 0957-5243 KW - Toxicology Abstracts KW - Genomes KW - Tobacco smoking KW - Classification KW - Urinary bladder KW - Risk factors KW - Risk groups KW - Diesel KW - urothelial carcinoma KW - Occupational exposure KW - Exhausts KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868337768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Smoking+status%2C+usual+adult+occupation%2C+and+risk+of+recurrent+urothelial+bladder+carcinoma%3A+data+from+The+Cancer+Genome+Atlas+%28TCGA%29+Project&rft.au=Wilcox%2C+Amber+N%3BSilverman%2C+Debra+T%3BFriesen%2C+Melissa+C%3BLocke%2C+Sarah+J%3BRuss%2C+Daniel+E%3BHyun%2C+Noorie%3BColt%2C+Joanne+S%3BFigueroa%2C+Jonine+D%3BRothman%2C+Nathaniel%3BMoore%2C+Lee+E%3BKoutros%2C+Stella&rft.aulast=Wilcox&rft.aufirst=Amber&rft.date=2016-12-01&rft.volume=27&rft.issue=12&rft.spage=1429&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-016-0821-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Number of references - 19 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Genomes; Tobacco smoking; Classification; Urinary bladder; Risk factors; Risk groups; Diesel; urothelial carcinoma; Occupational exposure; Exhausts DO - http://dx.doi.org/10.1007/s10552-016-0821-7 ER - TY - JOUR T1 - Biodosimetry: Medicine, Science, and Systems to Support the Medical Decision-Maker Following a Large Scale Nuclear or Radiation Incident AN - 1868318008; PQ0004026991 AB - The public health and medical response to a radiological or nuclear incident requires the capability to sort, assess, treat, triage and to ultimately discharge, refer or transport people to their next step in medical care. The size of the incident and scarcity of resources at the location of each medical decision point will determine how patients are triaged and treated. This will be a rapidly evolving situation impacting medical responders at regional, national and international levels. As capabilities, diagnostics and medical countermeasures improve, a dynamic system-based approach is needed to plan for and manage the incident, and to adapt effectively in real time. In that the concepts and terms can be unfamiliar and possibly confusing, resources and a concept of operations must be considered well in advance. An essential underlying tenet is that medical evaluation and care will be managed by healthcare professionals with biodosimetry assays providing critical supporting data. JF - Radiation Protection Dosimetry AU - Coleman, C Norman AU - Koerner, John F AD - Chemical, Biological, Radiological, Nuclear and Explosive Branch, Office of Emergency Management, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC 20201, USA, john.koerner@hhs.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 38 EP - 46 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 172 IS - 1-3 SN - 0144-8420, 0144-8420 KW - Toxicology Abstracts; Environment Abstracts KW - Radiation KW - Dosimetry KW - Public health KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868318008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Biodosimetry%3A+Medicine%2C+Science%2C+and+Systems+to+Support+the+Medical+Decision-Maker+Following+a+Large+Scale+Nuclear+or+Radiation+Incident&rft.au=Coleman%2C+C+Norman%3BKoerner%2C+John+F&rft.aulast=Coleman&rft.aufirst=C&rft.date=2016-12-01&rft.volume=172&rft.issue=1-3&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncw155 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Radiation; Dosimetry; Public health DO - http://dx.doi.org/10.1093/rpd/ncw155 ER - TY - JOUR T1 - Human antibody repertoire after VSV-Ebola vaccination identifies novel targets and virus-neutralizing IgM antibodies AN - 1855083311; PQ0003943523 AB - Development of an effective vaccine against Ebola virus is of high priority. However, knowledge about potential correlates of protection and the durability of immune response after vaccination is limited. Here, we elucidate the human antibody repertoire after administration of vesicular stomatitis virus (VSV)-Ebola vaccine at 3 million, 20 million and 100 million plaque-forming units (PFU) and homologous VSV-Ebola vaccine boost in healthy adult volunteers. Whole genome-fragment phage display libraries, expressing linear and conformational epitopes of Ebola glycoprotein (GP), showed higher diversity of antibody epitopes in individuals vaccinated with 20 million PFU than in those vaccinated with 3 million or 100 million PFU. Surface plasmon resonance kinetics showed higher levels of GP-binding antibodies after a single vaccination with 20 million or 100 million PFU than with 3 million PFU, and these correlated strongly with neutralization titers. A second vaccination did not boost antibody or virus neutralization titers, which declined rapidly, and induced only minimal antibody affinity maturation. Isotype analysis revealed a predominant IgM response even after the second vaccination, which contributed substantially to virus neutralization in vitro. These findings may help identify new vaccine targets and aid development and evaluation of effective countermeasures against Ebola. JF - Nature Medicine AU - Khurana, Surender AU - Fuentes, Sandra AU - Coyle, Elizabeth M AU - Ravichandran, Supriya AU - Davey, Richard T AU - Beigel, John H AD - Division of Viral Products, Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1439 EP - 1447 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 22 IS - 12 SN - 1078-8956, 1078-8956 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - surface plasmon resonance KW - Ebolavirus KW - Rhabdoviridae KW - Kinetics KW - Phage display KW - Vaccines KW - Immune response KW - Glycoproteins KW - Vaccination KW - Immunoglobulin M KW - Epitopes KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855083311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Human+antibody+repertoire+after+VSV-Ebola+vaccination+identifies+novel+targets+and+virus-neutralizing+IgM+antibodies&rft.au=Khurana%2C+Surender%3BFuentes%2C+Sandra%3BCoyle%2C+Elizabeth+M%3BRavichandran%2C+Supriya%3BDavey%2C+Richard+T%3BBeigel%2C+John+H&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2016-12-01&rft.volume=22&rft.issue=12&rft.spage=1439&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm.4201 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - surface plasmon resonance; Kinetics; Phage display; Glycoproteins; Immune response; Vaccines; Vaccination; Epitopes; Immunoglobulin M; Rhabdoviridae; Ebolavirus DO - http://dx.doi.org/10.1038/nm.4201 ER - TY - JOUR T1 - Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat AN - 1850772854; PQ0003896462 AB - Prolonged vitamin B1 (thiamine) deficiency can lead to neurological disorders such as Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome (WKS) in humans. These thiamine deficiency disorders have been attributed to vascular leakage, blood-brain barrier breakdown and neuronal loss in the diencephalon and brain stem. However, endothelial dysfunction following thiamine deficiency and its relationship to the phenomenon of neurodegeneration has not been clearly elucidated. The present study sought to begin to address this issue by evaluating vascular morphology and integrity in a pyrithiamine (PT)-induced rat model of thiamine deficiency. Adjacent brain sections were used to either assess vascular integrity through immunohistochemical localization of rat endothelial cell antigen (RECA-1) and endothelial brain barrier antigen (EBA-1) or neurodegeneration using the de Olmos cupric silver method. GFAP and CD11b immunolabeling was used to evaluate astrocytic and microglial/macrophagic changes. Extensive neurodegeneration occurred concomitant with both vascular damage (thinning and breakage) and microglial activation in the inferior olive, medial thalamic area, and medial geniculate nuclei of pyrithiamine treated rats. Likewise, glucose transporter-1 (Glut-1), which is mostly expressed in endothelial cells, was also severely decreased in this pyrithiamine induced thiamine deficient rat model. MRI scans of these animals prior to sacrifice show that the pyrithiamine induced thiamine deficient animals have abnormal T2 relaxation values, which are commensurate with, and possibly predictive of, the neurodegeneration and/or endothelial dysfunction subsequently observed histologically in these same animals. JF - Neurotoxicology AU - Sarkar, Sumit AU - Liachenko, Serguei AU - Paule, Merle G AU - Bowyer, John AU - Hanig, Joseph P AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR-72079, USA Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 298 EP - 309 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 57 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Pyrithiamine KW - Endothelial cells KW - Astrocytes KW - Microglia KW - Neurodegeneration KW - pyrithiamine KW - Neurological diseases KW - Leakage KW - Blood-brain barrier KW - Magnetic resonance imaging KW - Brain stem KW - Glial fibrillary acidic protein KW - Thiamine KW - Thalamus KW - Diencephalon KW - Thinning KW - Nutrient deficiency KW - Vitamins KW - CD11b antigen KW - Wernicke's encephalopathy KW - Silver KW - N3 11028:Neuropharmacology & toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850772854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Brain+endothelial+dysfunction+following+pyrithiamine+induced+thiamine+deficiency+in+the+rat&rft.au=Sarkar%2C+Sumit%3BLiachenko%2C+Serguei%3BPaule%2C+Merle+G%3BBowyer%2C+John%3BHanig%2C+Joseph+P&rft.aulast=Sarkar&rft.aufirst=Sumit&rft.date=2016-12-01&rft.volume=57&rft.issue=&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2016.10.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - pyrithiamine; Leakage; Neurological diseases; Blood-brain barrier; Brain stem; Magnetic resonance imaging; Thiamine; Glial fibrillary acidic protein; Neurodegeneration; Thalamus; Diencephalon; Endothelial cells; Thinning; Nutrient deficiency; CD11b antigen; Vitamins; Wernicke's encephalopathy; Silver DO - http://dx.doi.org/10.1016/j.neuro.2016.10.014 ER - TY - JOUR T1 - Depletion of florfenicol in lactating dairy cows after intramammary and subcutaneous administration AN - 1846409278; PQ0003816373 AB - Eighteen Holstein dairy cows ranging in body weight from 500-700 kg and with an average milk yield of 37 plus or minus 6 kg/day were used to investigate the depletion of florfenicol (FFL) in milk and plasma of dairy cows. Three groups of six were administered FFL: Group A, intramammary (IMM) infusion of ~2.5 mg FFL/kg BW at three consecutive milking intervals (total amount of ~7.5 mg/kg BW); Group B, one IMM infusion (20 mg/kg BW) into one quarter and Group C, one subcutaneous (SC) treatment (40 mg/kg BW). IMM infusions were into the right front quarter. Cows were milked daily at 06:00 and 18:00 h. The highest concentrations (C sub(max)) and time to C sub(max) (T sub(max)) were: 1.6 plus or minus 2.2 mu g.FFL/mL milk at 22 h (Group A), 5.5 plus or minus 3.6 mu g.FFL/mL milk at 12 h (Group B), and 1.7 plus or minus 0.4 mu g.FFL/mL milk at 12 h (Group C). The half-lives (t sub(1/2)) were ~19, 5.5, and 60 h, for Groups A, B, and C, respectively. FFL was below the limit of detection (LOD) by 60 h in three Group B cows, but above the LOD at 72, 84, and 120 h in three cows. FFL was above the LOD in milk from Group C's cows for 432-588 h. Plasma values followed the same trends as milk. The results demonstrate that IMM-infused FFL is bioavailable and below the LOD within 72-120 h. The concentration of FFL was detectable in both plasma and milk over the course of 2-3 weeks after SC administration. The absence of residue depletion data presents problems in determining safe levels of FFL residues in milk and edible tissues. The data presented here must not be construed as approval for extra-label use in food animals. JF - Journal of Veterinary Pharmacology and Therapeutics AU - Kawalek, J C AU - Howard, K D AU - Jones, Y AU - Scott, M L AU - Myers, MJ AD - Division of Applied Veterinary Research, U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, MD, USA. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 602 EP - 611 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 39 IS - 6 SN - 0140-7783, 0140-7783 KW - Biotechnology and Bioengineering Abstracts KW - Dairies KW - Data processing KW - Body weight KW - Food KW - Florfenicol KW - Milking KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846409278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.atitle=Depletion+of+florfenicol+in+lactating+dairy+cows+after+intramammary+and+subcutaneous+administration&rft.au=Kawalek%2C+J+C%3BHoward%2C+K+D%3BJones%2C+Y%3BScott%2C+M+L%3BMyers%2C+MJ&rft.aulast=Kawalek&rft.aufirst=J&rft.date=2016-12-01&rft.volume=39&rft.issue=6&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.issn=01407783&rft_id=info:doi/10.1111%2Fjvp.12315 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Dairies; Data processing; Body weight; Food; Milking; Florfenicol DO - http://dx.doi.org/10.1111/jvp.12315 ER - TY - JOUR T1 - Development of methods for using workers' compensation data for surveillance and prevention of occupational injuries among State-insured private employers in Ohio AN - 1846395255; PQ0003858697 AB - Background Workers' compensation (WC) claims data may be useful for identifying high-risk industries and developing prevention strategies. Methods WC claims data from private-industry employers insured by the Ohio state-based workers' compensation carrier from 2001 to 2011 were linked with the state's unemployment insurance (UI) data on the employer's industry and number of employees. National Labor Productivity and Costs survey data were used to adjust UI data and estimate full-time equivalents (FTE). Rates of WC claims per 100 FTE were computed and Poisson regression was used to evaluate differences in rates. Results Most industries showed substantial claim count and rate reductions from 2001 to 2008, followed by a leveling or slight increase in claim count and rate from 2009 to 2011. Despite reductions, there were industry groups that had consistently higher rates. Conclusion WC claims data linked to employment data could be used to prioritize industries for injury research and prevention activities among State-insured private employers. Am. J. Ind. Med. 59:1087-1104, 2016. JF - American Journal of Industrial Medicine AU - Wurzelbacher, Steven J AU - Al-Tarawneh, Ibraheem S AU - Meyers, Alysha R AU - Bushnell, PTimothy AU - Lampl, Michael P AU - Robins, David C AU - Tseng, Chih-Yu AU - Wei, Chia AU - Bertke, Stephen J AU - Raudabaugh, Jill A AU - Haviland, Thomas M AU - Schnorr, Teresa M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, Center for Workers' Compensation Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1087 EP - 1104 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 12 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Data processing KW - Injuries KW - Unemployment KW - Occupational safety KW - Employment KW - Insurance KW - Workers' compensation KW - Prevention KW - Labor productivity KW - Risk groups KW - USA, Ohio KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846395255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Development+of+methods+for+using+workers%27+compensation+data+for+surveillance+and+prevention+of+occupational+injuries+among+State-insured+private+employers+in+Ohio&rft.au=Wurzelbacher%2C+Steven+J%3BAl-Tarawneh%2C+Ibraheem+S%3BMeyers%2C+Alysha+R%3BBushnell%2C+PTimothy%3BLampl%2C+Michael+P%3BRobins%2C+David+C%3BTseng%2C+Chih-Yu%3BWei%2C+Chia%3BBertke%2C+Stephen+J%3BRaudabaugh%2C+Jill+A%3BHaviland%2C+Thomas+M%3BSchnorr%2C+Teresa+M&rft.aulast=Wurzelbacher&rft.aufirst=Steven&rft.date=2016-12-01&rft.volume=59&rft.issue=12&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22653 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Data processing; Injuries; Risk groups; Workers' compensation; Prevention; Labor productivity; Unemployment; Occupational safety; Employment; Insurance; USA, Ohio DO - http://dx.doi.org/10.1002/ajim.22653 ER - TY - JOUR T1 - Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells. AN - 1846365584; 27613715 AB - Nefazodone, an antagonist for the 5-hydroxytryptanine receptor, has been used for the treatment of depression. Acute liver injury has been documented to be associated with the use of nefazodone; however, the mechanisms of nefazodone-induced liver toxicity are not well defined. In this report, using biochemical and molecular analyses, we characterized the molecular mechanisms underlying the hepatotoxicity of nefazodone. We found that nefazodone induced endoplasmic reticulum (ER) stress in HepG2 cells, as the expression of typical ER stress markers, including CHOP, ATF-4, and p-eIF2α, was significantly increased, and splicing of XBP1 was observed. Nefazodone-suppressed protein secretion was evaluated using a Gaussia luciferase reporter assay that measures ER stress. The ER stress inhibitors (4-phenylbutyrate and salubrinal) and knockdown of ATF-4 gene attenuated nefazodone-induced ER stress and cytotoxicity. Nefazodone activated the MAPK signaling pathway, as indicated by increased phosphorylation of JNK, ERK1/2, and p38. Inhibition of ERK1/2 reduced ER stress caused by nefazodone. Taken together, our findings suggest that ER stress contributes to nefazodone-induced toxicity in HepG2 cells and that the MAPK signaling pathway plays an important role in ER stress. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Ren, Zhen AU - Chen, Si AU - Zhang, Jie AU - Doshi, Utkarsh AU - Li, Albert P AU - Guo, Lei AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, Arkansas. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. FDA, Jefferson, Arkansas. ; In Vitro ADMET Laboratories LLC, Columbia, Maryland. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, Arkansas; Lei.Guo@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 368 EP - 380 VL - 154 IS - 2 KW - MAPK pathway KW - nefazodone. KW - reporter gene assay KW - drug-induced liver toxicity KW - endoplasmic reticulum stress (ER stress) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846365584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Endoplasmic+Reticulum+Stress+Induction+and+ERK1%2F2+Activation+Contribute+to+Nefazodone-Induced+Toxicity+in+Hepatic+Cells.&rft.au=Ren%2C+Zhen%3BChen%2C+Si%3BZhang%2C+Jie%3BDoshi%2C+Utkarsh%3BLi%2C+Albert+P%3BGuo%2C+Lei&rft.aulast=Ren&rft.aufirst=Zhen&rft.date=2016-12-01&rft.volume=154&rft.issue=2&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Battle in the New World: Helicoverpa armigera versus Helicoverpa zea (Lepidoptera: Noctuidae) AN - 1845257766 AB - The corn earworm Helicoverpa zea (Boddie) and the old world bollworm Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) are allopatric species and occur in important agricultural crops. In maize, both species tend to infest the ear. The introduction of H. armigera in Brazil has created a new scenario, where these Helicoverpa species might cohabit and interact with one another, affecting the prevalence of each species in the agroecosystem, integrated pest management, and insect resistance management. In this study, larval occurrence and proportion of these species in maize was assessed in three regions of Brazil during three crop seasons. Interaction between the species was evaluated in interspecific and intraspecific scenarios under laboratory and field conditions. Helicoverpa zea was predominant in Rio Grande do Sul and the Planaltina, DF (central Brazil). In western Bahia, H. zea was predominant in the first collection, but approximately equal in number to H armigera in the second crop season. Both species exhibit high cannibalism/predation rates, and larval size was the primary factor for larval survival in the interaction studies. Larva of H. zea had higher survival when interacting with H. armigera, indicating that H. zea has an advantage in intraguild interactions with H. armigera in maize. Overall, the results from this study indicate that maize might play a role as a source of infestation or a sink of insecticide or Bt protein unselected H. armigera populations, depending on the H. zea:H. armigera intraguild competition and adult movement in the landscape. JF - PLoS One AU - Bentivenha, José PF AU - Paula-Moraes, Silvana V AU - Baldin, Edson LL AU - Specht, Alexandre AU - Silva, Ivana Fda AU - Hunt, Thomas E Y1 - 2016/12// PY - 2016 DA - Dec 2016 CY - San Francisco PB - Public Library of Science VL - 11 IS - 12 KW - Sciences: Comprehensive Works KW - Insecticides KW - Proteins KW - Studies KW - Seasons KW - Corn KW - Butterflies & moths KW - Laboratories KW - Soybeans KW - United States--US KW - Florida UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1845257766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=Battle+in+the+New+World%3A+Helicoverpa+armigera+versus+Helicoverpa+zea+%28Lepidoptera%3A+Noctuidae%29&rft.au=Bentivenha%2C+Jos%C3%A9+PF%3BPaula-Moraes%2C+Silvana+V%3BBaldin%2C+Edson+LL%3BSpecht%2C+Alexandre%3BSilva%2C+Ivana+Fda%3BHunt%2C+Thomas+E&rft.aulast=Bentivenha&rft.aufirst=Jos%C3%A9&rft.date=2016-12-01&rft.volume=11&rft.issue=12&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pone.0167182 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Citation: Bentivenha JPF, Paula-Moraes SV, Baldin ELL, Specht A, da Silva IF, Hunt TE (2016) Battle in the New World: Helicoverpa armigera versus Helicoverpa zea (Lepidoptera: Noctuidae). PLoS ONE 11(12): e0167182. doi:10.1371/journal.pone.0167182 N1 - Last updated - 2016-12-03 N1 - SubjectsTermNotLitGenreText - Florida; United States--US DO - http://dx.doi.org/10.1371/journal.pone.0167182 ER - TY - JOUR T1 - Stability of core language skill across the first decade of life in children at biological and social risk AN - 1845015267 AB - Background Command of language is a fundamental skill, a cornerstone of multiple cognitive and socioemotional aspects of development, and a necessary ingredient of successful adjustment and functioning in society. Little is known about the developmental stability of language in at-risk youth or which biological and social risk factors moderate stability. Methods This four-wave 10-year prospective longitudinal study evaluated stability of core language skill in 1,780 children in varying categories of biological and social risk in a multiage, multidomain, multimeasure, and multireporter framework. Results Structural equation modeling supported loadings of diverse age-appropriate measures of child language on single latent variables of core language skill at 15 and 25 months and 5 and 11 years, respectively. Core language skill was stable over the first decade of life; significant and comparable stability coefficients were obtained for children with diverse biological and social risks, including poor health, welfare status, teen motherhood, ethnicity, gender, birth order, and families that changed in income and maternal education over the study period; stability in language was strong even accounting for child nonverbal intelligence and social competence, maternal education and language, and the family home environment. Conclusions Core language skill varies in stability with age but is robustly stable in children regardless of multiple biological and social risk factors. JF - Journal of Child Psychology and Psychiatry AU - Bornstein, Marc H AU - Hahn, Chun-Shin AU - Putnick, Diane L AD - Child and Family Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Public Health Service, Bethesda, MD, USA ; Child and Family Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Public Health Service, Bethesda, MD, USA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 1434 EP - 1443 CY - Malden PB - Wiley Subscription Services, Inc. VL - 57 IS - 12 KW - Psychology KW - At risk KW - Intelligence KW - Birth order KW - Socioemotional aspects KW - Home environment KW - Risk factors KW - Ethnicity KW - Health status KW - Welfare KW - Social competence KW - Motherhood KW - Nonverbal intelligence KW - Adolescent motherhood KW - Childbirth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1845015267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Stability+of+core+language+skill+across+the+first+decade+of+life+in+children+at+biological+and+social+risk&rft.au=Bornstein%2C+Marc+H%3BHahn%2C+Chun-Shin%3BPutnick%2C+Diane+L&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2016-12-01&rft.volume=57&rft.issue=12&rft.spage=1434&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Psychology+and+Psychiatry&rft.issn=&rft_id=info:doi/10.1111%2Fjcpp.12632 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © 2016 Association for Child and Adolescent Mental Health. N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1111/jcpp.12632 ER - TY - JOUR T1 - An Examination of Hospital Nurse Staffing and Patient Experience with Care: Differences between Cross-Sectional and Longitudinal Estimates AN - 1844983395 AB - Objective To study the association between hospital nurse staffing and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores. Data Sources State hospital financial and utilization reports, Healthcare Cost and Utilization Project State Inpatient Databases, HCAHPS survey, and American Hospital Association Annual Survey of Hospitals. Study Design Retrospective study using cross-sectional and longitudinal models to estimate the effect of nurse staffing levels and skill mix on seven HCAHPS measures. Data Collection/Extraction Methods Hospital-level data measuring nurse staffing, patient experience, and hospital characteristics from 2009 to 2011 for 341 hospitals (977 hospital years) in California, Maryland, and Nevada. Principal Findings Nurse staffing level (i.e., number of licensed practical nurses and registered nurses per 1,000 inpatient days) was significantly and positively associated with all seven HCAHPS measures in cross-sectional models and three of seven measures in longitudinal models. Nursing skill mix (i.e., percentage of all staff who are registered nurses) was significantly and negatively associated with scores on one measure in cross-sectional models and none in longitudinal models. Conclusions After controlling for unobserved hospital characteristics, the positive influences of increased nurse staffing levels and skill mix were relatively small in size and limited to a few measures of patients' inpatient experience. JF - Health Services Research AU - Martsolf, Grant R AU - Gibson, Teresa B AU - Benevent, Richele AU - Jiang, H Joanna AU - Stocks, Carol AU - Ehrlich, Emily D AU - Kandrack, Ryan AU - Auerbach, David I AD - RAND Corporation, Pittsburgh, PA ; Health Outcomes Research, Truven Health Analytics, Ann Arbor, MI ; Health Outcomes Research, Truven Health Analytics, Santa Barbara, CA ; Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, MD ; Health Research Division, Mathematica Policy Research, Ann Arbor, MI ; Center for Interdisciplinary Health Workforce Studies at Montana State University, Bozeman, MT ; RAND Corporation, Pittsburgh, PA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 2221 EP - 2241 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 51 IS - 6 SN - 0017-9124 KW - Medical Sciences KW - Surveys KW - Databases KW - Health costs KW - Practice nurses KW - Staffing KW - Staffing levels KW - Patient care KW - Health care industry KW - Extraction KW - Hospitalization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844983395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=An+Examination+of+Hospital+Nurse+Staffing+and+Patient+Experience+with+Care%3A+Differences+between+Cross-Sectional+and+Longitudinal+Estimates&rft.au=Martsolf%2C+Grant+R%3BGibson%2C+Teresa+B%3BBenevent%2C+Richele%3BJiang%2C+H+Joanna%3BStocks%2C+Carol%3BEhrlich%2C+Emily+D%3BKandrack%2C+Ryan%3BAuerbach%2C+David+I&rft.aulast=Martsolf&rft.aufirst=Grant&rft.date=2016-12-01&rft.volume=51&rft.issue=6&rft.spage=2221&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12462 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1111/1475-6773.12462 ER - TY - JOUR T1 - Paving the Way for Progress: The Agency for Healthcare Research and Quality Patient Safety and Medical Liability Demonstration Initiative AN - 1844981942 JF - Health Services Research AU - Battles, James B AU - Reback, Kathryn A AU - Azam, Irim AD - Agency for Healthcare Research and Quality, Rockville, MD ; Agency for Healthcare Research and Quality, Rockville, MD Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 2401 EP - 2413 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 51 IS - S3 SN - 0017-9124 KW - Medical Sciences KW - Health care KW - Medical research KW - Liability KW - Patient care KW - Safety measures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844981942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Paving+the+Way+for+Progress%3A+The+Agency+for+Healthcare+Research+and+Quality+Patient+Safety+and+Medical+Liability+Demonstration+Initiative&rft.au=Battles%2C+James+B%3BReback%2C+Kathryn+A%3BAzam%2C+Irim&rft.aulast=Battles&rft.aufirst=James&rft.date=2016-12-01&rft.volume=51&rft.issue=S3&rft.spage=2401&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12632 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1111/1475-6773.12632 ER - TY - JOUR T1 - Bullying and Victimization Among Young Elementary School Children: The Role of Child Ethnicity and Ethnic School Composition AN - 1842450147 AB - School-aged children with an ethnic minority background are relatively often involved in bullying and victimization, but the role of ethnic composition of schools in this context remains unclear. This study examined the relation between ethnic minority background, ethnic school composition, and bullying behaviour around primary school entry in the Netherlands. The study was based on a 2008/2009 school survey in Rotterdam, a Dutch city where about 50 % of children have a non-Dutch background. For 8523 children, teacher reports of bullying behaviour at age 5-6 years were available. Children with a non-Dutch background had higher odds of being a victim (adjusted OR 1.41, 95 % CI 1.11, 1.80), bully (OR 1.38, 95 % CI 1.20, 1.58) or bully-victim (OR 1.38, 95 % CI 1.19, 1.62) than children of Dutch national origin. Ethnic diversity in schools increased children's risk of bullying behaviour (e.g. ORvictim per 0.1 increase in 0-1 diversity range = 1.06, 95 % CI 1.00, 1.13), with children of both Dutch and non-Dutch national origin relatively more often involved in bullying in ethnically diverse schools. The proportion of same-ethnic peers in school reduced the risk of bullying among children of Dutch national origin (e.g. ORvictim per 10 % more same-ethnic children = 0.90, 95 % CI 0.83, 0.98), but not among non-Dutch children. In conclusion, ethnic minority background and ethnic diversity within schools are risk factors for bullying among 5-6 year olds. Plausibly, reductions in absolute numbers of bullying events may be obtained with tailor-made interventions in ethnically diverse schools. Such interventions should preferably be offered early in the school curriculum. JF - Race and Social Problems AU - Jansen, Pauline W AU - Mieloo, Cathelijne L AU - Dommisse-van Berkel, Anke AU - Verlinden, Marina AU - van der Ende, Jan AU - Stevens, Gonneke AU - Verhulst, Frank C AU - Jansen, Wilma AU - Tiemeier, Henning AD - Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands; Institute of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands ; Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands; Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands ; Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands ; Utrecht Centre of Child and Adolescent Studies, Utrecht University, Utrecht, The Netherlands ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Psychiatry, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands; Institute of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 271 EP - 280 CY - New York PB - Springer Science & Business Media VL - 8 IS - 4 SN - 1867-1748 KW - Social Sciences: Comprehensive Works KW - Bullying KW - Victimization KW - Ethnicity KW - Ethnic diversity KW - School KW - Child KW - Minority Groups KW - Cultural Pluralism KW - Aggression KW - Victims KW - Risk Factors KW - Peers KW - Ethnic Groups KW - Elementary Schools KW - Curriculum KW - Children KW - Elderly KW - Schools UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842450147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Race+and+Social+Problems&rft.atitle=Bullying+and+Victimization+Among+Young+Elementary+School+Children%3A+The+Role+of+Child+Ethnicity+and+Ethnic+School+Composition&rft.au=Jansen%2C+Pauline+W%3BMieloo%2C+Cathelijne+L%3BDommisse-van+Berkel%2C+Anke%3BVerlinden%2C+Marina%3Bvan+der+Ende%2C+Jan%3BStevens%2C+Gonneke%3BVerhulst%2C+Frank+C%3BJansen%2C+Wilma%3BTiemeier%2C+Henning&rft.aulast=Jansen&rft.aufirst=Pauline&rft.date=2016-12-01&rft.volume=8&rft.issue=4&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Race+and+Social+Problems&rft.issn=18671748&rft_id=info:doi/10.1007%2Fs12552-016-9182-9 LA - English DB - Social Services Abstracts; Sociological Abstracts N1 - Copyright - Race and Social Problems is a copyright of Springer, 2016. N1 - Last updated - 2017-01-27 DO - http://dx.doi.org/10.1007/s12552-016-9182-9 ER - TY - JOUR T1 - Pharmacodynamic study of the oral hedgehog pathway inhibitor, vismodegib, in patients with metastatic castration-resistant prostate cancer. AN - 1839107218; 27826729 AB - Hedgehog (Hh) pathway signaling has been implicated in prostate cancer tumorigenesis and metastatic development and may be upregulated even further in the castration-resistant state. We hypothesized that antagonism of the Hh pathway with vismodegib in men with metastatic castration-resistant prostate cancer (mCRPC) would result in pathway engagement, inhibition and perhaps induce measurable clinical responses in patients. This is a single-arm study of oral daily vismodegib in men with mCRPC. All patients were required to have biopsies of the tumor and skin (a surrogate tissue) at baseline and after 4 weeks of therapy. Ten patients were planned for enrollment. The primary outcome was the pharmacodynamic assessment of Gli1 mRNA suppression with vismodegib in tumor tissue. Secondary outcomes included PSA response rates, progression-free survival (PFS), overall survival (OS) and safety. Nine patients were enrolled. Gli1 mRNA was significantly suppressed by vismodegib in both tumor tissue (4/7 evaluable biopsies, 57%) and benign skin biopsies (6/8 evaluable biopsies, 75%). The median number of treatment cycles completed was three, with a median PFS of 1.9 months (95% CI 1.3, NA), and a median OS of 7.04 months (95% CI 3.4, NA). No patient achieved a PSA reduction or a measurable tumor response. Safety data were consistent with the known toxicities of vismodegib. Hh signaling, as measured by Gli1 mRNA expression in mCRPC tissues, was suppressed with vismodegib in the majority of patients. Despite this pharmacodynamic response that indicated target inhibition in some patients, there was no apparent signal of clinical activity. Vismodegib will not be developed further as monotherapy in mCRPC. JF - Cancer chemotherapy and pharmacology AU - Maughan, Benjamin L AU - Suzman, Daniel L AU - Luber, Brandon AU - Wang, Hao AU - Glavaris, Stephanie AU - Hughes, Robert AU - Sullivan, Rana AU - Harb, Rana AU - Boudadi, Karim AU - Paller, Channing AU - Eisenberger, Mario AU - Demarzo, Angelo AU - Ross, Ashely AU - Antonarakis, Emmanuel S AD - Huntsman Cancer Center, University of Utah, 2000 Circle of Hope Dr, Salt Lake City, UT, 84112, USA. ; Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993, USA. ; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans St. CRB1 1M45, Baltimore, MD, 21287, USA. ; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans St. CRB1 1M45, Baltimore, MD, 21287, USA. eantona1@jhmi.edu. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1297 EP - 1304 VL - 78 IS - 6 KW - Gli KW - Hedgehog KW - Metastatic castration-resistant prostate cancer KW - Vismodegib UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1839107218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Pharmacodynamic+study+of+the+oral+hedgehog+pathway+inhibitor%2C+vismodegib%2C+in+patients+with+metastatic+castration-resistant+prostate+cancer.&rft.au=Maughan%2C+Benjamin+L%3BSuzman%2C+Daniel+L%3BLuber%2C+Brandon%3BWang%2C+Hao%3BGlavaris%2C+Stephanie%3BHughes%2C+Robert%3BSullivan%2C+Rana%3BHarb%2C+Rana%3BBoudadi%2C+Karim%3BPaller%2C+Channing%3BEisenberger%2C+Mario%3BDemarzo%2C+Angelo%3BRoss%2C+Ashely%3BAntonarakis%2C+Emmanuel+S&rft.aulast=Maughan&rft.aufirst=Benjamin&rft.date=2016-12-01&rft.volume=78&rft.issue=6&rft.spage=1297&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Outcomes for a Public Hospital Tobacco Cessation Program: The Cook County Health and Hospitals System Experience AN - 1837315645; PQ0003812660 AB - The objective of this study is to determine the rate and predictors of sustained smoking cessation for a cohort of smokers exposed to a guideline-based health education program delivered during routine clinical care at an urban public hospital. This is a retrospective analysis of 755 public hospital system patients who had at least two health educator contacts embedded in routine clinical care, with the latter contact 12-18 months after the baseline. The education occurred during visits to primary care, specialty clinics, urgent/episodic care, or during hospitalization. The assessment of smoking status is determined by the health educators as part of their routine assessment and recorded in the program's database. The primary outcomes are self-reported 12-month sustained smoking cessation at the 12-18 month contact and predictors of cessation. The cohort is predominantly minority smokers (African American 69 % and Latino 15 %) and uninsured (70 %) or on Medicaid (13 %). The sustained cessation rate was 9.3 %. Latino ethnicity, smoking 1-9 cigarettes/day at baseline, reporting smoke-free home, and additional educator contact in the year after the baseline were independent predictors of sustained cessation in the multivariate analysis. Smokers with multiple risks for poor cessation outcomes exposed to a guideline-based program of health education during routine healthcare encounters had sustained smoking cessation rates that compare favorably with published National Health Interview Study population cessation rates. An additional educator contact after the baseline was a predictor of cessation. The findings support development of cessation programs in which health educators are integrated into clinical care settings. JF - Journal of Community Health AU - Goldberg, David N AU - Krantz, Anne J AU - Semal, Sara AU - Zhang, Huiyuan AU - Trick, William E AD - Division of General Internal Medicine, Cook County Health and Hospitals System, Chicago, IL, USA, david.goldberg@ihs.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1130 EP - 1139 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 41 IS - 6 SN - 0094-5145, 0094-5145 KW - Health & Safety Science Abstracts KW - Risk assessment KW - Cigarettes KW - Health care KW - Cigarette smoking KW - Tobacco KW - Socioeconomics KW - Ethnic groups KW - Data bases KW - Hospitals KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837315645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Outcomes+for+a+Public+Hospital+Tobacco+Cessation+Program%3A+The+Cook+County+Health+and+Hospitals+System+Experience&rft.au=Goldberg%2C+David+N%3BKrantz%2C+Anne+J%3BSemal%2C+Sara%3BZhang%2C+Huiyuan%3BTrick%2C+William+E&rft.aulast=Goldberg&rft.aufirst=David&rft.date=2016-12-01&rft.volume=41&rft.issue=6&rft.spage=1130&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-016-0215-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 46 N1 - Last updated - 2016-11-23 N1 - SubjectsTermNotLitGenreText - Risk assessment; Health care; Cigarettes; Cigarette smoking; Tobacco; Socioeconomics; Data bases; Ethnic groups; Hospitals DO - http://dx.doi.org/10.1007/s10900-016-0215-5 ER - TY - JOUR T1 - Effects of maternal silver acetate exposure on immune biomarkers in a rodent model. AN - 1835689543; 27789322 AB - Male and female rats (26-day old) were exposed to 0.0, 0.4, 4 or 40 mg/kg body weight silver acetate (AgAc) in drinking water for 10 weeks prior to and during mating. Sperm positive females remained within their dose groups and were exposed to AgAc during gestation and lactation. Splenic and thymic lymphocyte subsets from F1 generation PD (postnatal day) 4 and 26 pups were assessed by flow cytometry for changes in phenotypic markers. Spleens from PD4 pups had lower percentages of CD8+ lymphocytes in 4 and 40 mg/kg AgAc exposed groups and reduced Concanavalin A (Con A) response at all AgAc exposure groups. Splenic maturation increased in PD26 pups compared to PD4 pups. Con A and lipopolysaccharide (LPS) mediated splenic responses were lower in PD26 pups exposed to 40 mg/kg AgAc. Changes in PD 26 pup splenocyte phenotypic markers included lower TCR + cells at 4 and 40 mg/kg AgAc exposure and higher B cell population in the 40 mg/kg AgAc. PD26 pup splenic natural killer cell (NK) activity was higher in the 0.4 AgAc group and unchanged in 4 and 40 mg/kg AgAc groups. In conclusion, maternal exposure to AgAc had a significant impact on rat splenic development during the early lactation period. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Babu, Uma S AU - Balan, Kannan V AU - Bigley, Elmer AU - Pereira, Marion AU - Black, Thomas AU - Olejnik, Nicholas AU - Keltner, Zachary AU - Sprando, Robert L AD - Division of Virulence Assessment, Office of Applied Research and Safety Assessment, CFSAN, U.S. FDA, Laurel, MD, United States. Electronic address: uma.babu@fda.hhs.gov. ; Division of Virulence Assessment, Office of Applied Research and Safety Assessment, CFSAN, U.S. FDA, Laurel, MD, United States. ; Division of Toxicology, Office of Applied Research and Safety Assessment, CFSAN, U.S. FDA, Laurel, MD, United States. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 195 EP - 200 VL - 98 KW - Silver acetate KW - Natural killer cell activity KW - Maternal exposure KW - Rodent model KW - Immune biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835689543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Effects+of+maternal+silver+acetate+exposure+on+immune+biomarkers%C2%A0in%C2%A0a%C2%A0rodent+model.&rft.au=Babu%2C+Uma+S%3BBalan%2C+Kannan+V%3BBigley%2C+Elmer%3BPereira%2C+Marion%3BBlack%2C+Thomas%3BOlejnik%2C+Nicholas%3BKeltner%2C+Zachary%3BSprando%2C+Robert+L&rft.aulast=Babu&rft.aufirst=Uma&rft.date=2016-12-01&rft.volume=98&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.10.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.10.022 ER - TY - GEN T1 - Editorial: MicroRNAs in toxicology and medicine: A special issue of the journal "Food and Chemical Toxicology". AN - 1835689154; 27523293 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Sahu, Saura C Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1 VL - 98 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835689154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Global+analysis+of+posttranscriptional+gene+expression+in+response+to+sodium+arsenite.&rft.au=Qiu%2C+Lian-Qun%3BAbey%2C+Sarah%3BHarris%2C+Shawn%3BShah%2C+Ruchir%3BGerrish%2C+Kevin+E%3BBlackshear%2C+Perry+J&rft.aulast=Qiu&rft.aufirst=Lian-Qun&rft.date=2015-04-01&rft.volume=123&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408626 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.08.015 ER - TY - JOUR T1 - MicroRNA-mediated maturation of human pluripotent stem cell-derived cardiomyocytes: Towards a better model for cardiotoxicity? AN - 1835677789; 27265266 AB - Human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) are a promising human cardiac model system for drug development and toxicity screening, along with cell therapy and mechanistic research. The scalable differentiation of human PSCs into CMs provides a renewable cell source that overcomes species differences present in rodent primary CMs. In addition, induced pluripotent stem cell (iPSC) technology allows for development of patient-specific CMs, representing a valuable tool that may lead to better prediction, prevention, and treatment of cardiovascular diseases in this new era of precision medicine. However, the utility of PSC-CMs as an in vitro model is currently limited by their immature phenotype when compared to adult CMs. Recent work has identified microRNAs (miRNAs) as critical regulators of heart development and function. These studies have shown that miRNAs are essential to key processes that span the life cycle of a cardiomyocyte, including proliferation, hypertrophy, beating rhythm, and apoptosis. Importantly, emerging evidence strongly suggests that modulation of select miRNAs can enhance the maturation of PSC-CMs. Here, we review key miRNAs associated with heart development and function, and discuss strategies to promote PSC-CM maturation, focusing on current knowledge surrounding miRNA-based approaches and the application of PSC-CMs with respect to drug screening and disease models. Ultimately, it is likely that combinations of both miRNA and non-miRNA maturation strategies may collectively provide the best path forward for producing mature cardiomyocytes in vitro. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - White, Matthew C AU - Pang, Li AU - Yang, Xi AD - Division of Systems Biology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA. ; Division of Systems Biology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA. Electronic address: Xi.Yang@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 17 EP - 24 VL - 98 KW - Maturation KW - Cardiomyocytes KW - MicroRNA KW - Human pluripotent stem cells KW - Disease modeling KW - Cardiotoxicity KW - Drug screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835677789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=MicroRNA-mediated+maturation+of+human+pluripotent+stem+cell-derived+cardiomyocytes%3A+Towards+a+better+model+for+cardiotoxicity%3F&rft.au=White%2C+Matthew+C%3BPang%2C+Li%3BYang%2C+Xi&rft.aulast=White&rft.aufirst=Matthew&rft.date=2016-12-01&rft.volume=98&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.05.025 ER - TY - JOUR T1 - Effect of smokeless tobacco products on human oral bacteria growth and viability. AN - 1835495884; 27756619 AB - To evaluate the toxicity of smokeless tobacco products (STPs) on oral bacteria, seven smokeless tobacco aqueous extracts (STAEs) from major brands of STPs and three tobacco-specific N-nitrosamines (TSNAs) were used in a growth and viability test against 38 oral bacterial species or subspecies. All seven STAEs showed concentration-dependent effects on the growth and viability of tested oral bacteria under anaerobic culture conditions, although there were strain-to-strain variations. In the presence of 1 mg/ml STAEs, the growth of 4 strains decreased over 0.32-2.14 log10 fold, while 14 strains demonstrated enhanced growth of 0.3-1.76 log10 fold, and the growth of 21 strains was not significantly affected. In the presence of 10 mg/ml STAEs, the growth of 17 strains was inhibited 0.3-2.11 log10 fold, 18 strains showed enhanced growth of 0.3-0.97 log10 fold, and 4 strains were not significantly affected. In the presence of 50 mg/ml STAEs, the growth of 32 strains was inhibited 0.3-2.96 log10 fold, 8 strains showed enhanced growth of 0.3-1.0 log10 fold, and 2 strains were not significantly affected. All seven STAEs could promote the growth of 4 bacterial strains, including Eubacterium nodatum, Peptostreptococcus micros, Streptococcus anginosus, and Streptococcus constellatus. Exposure to STAEs modulated the viability of some bacterial strains, with 21.1-66.5% decrease for 4 strains at 1 mg/ml, 20.3-85.7% decrease for 10 strains at 10 mg/ml, 20.0-93.3% decrease for 27 strains at 50 mg/ml, and no significant effect for 11 strains at up to 50 mg/ml. STAEs from snuffs inhibited more tested bacterial strains than those from snus indicating that the snuffs may be more toxic to the oral bacteria than snus. For TSNAs, cell growth and viability of 34 tested strains were not significantly affected at up to 100 μg/ml; while the growth of P. micros was enhanced 0.31-0.54 log10 fold; the growth of Veillonella parvula was repressed 0.33-0.36 log10 fold; and the cell viabilities of 2 strains decreased 56.6-69.9%. The results demonstrate that STAEs affected the growth of some types of oral bacteria, which may affect the healthy ecological balance of oral bacteria in humans. On the other hand, TSNAs did not significantly affect the growth of the oral bacteria. Published by Elsevier Ltd. JF - Anaerobe AU - Liu, Min AU - Jin, Jinshan AU - Pan, Hongmiao AU - Feng, Jinhui AU - Cerniglia, Carl E AU - Yang, Maocheng AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States; Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States; Key Laboratory of Marine Ecology & Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States; National Engineering Laboratory for Industrial Enzymes, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. ; Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993, United States. Electronic address: Maocheng.Yang@fda.hhs.gov. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States. Electronic address: Huizhong.Chen@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 152 EP - 161 VL - 42 KW - Complex Mixtures KW - 0 KW - Culture Media KW - Nitrosamines KW - Index Medicus KW - Smokeless tobacco KW - Oral bacteria KW - Cell viability KW - Toxicology KW - Tobacco-specific N-nitrosamines KW - Streptococcus anginosus -- isolation & purification KW - Veillonella -- drug effects KW - Humans KW - Hydrogen-Ion Concentration KW - Peptostreptococcus -- isolation & purification KW - Streptococcus anginosus -- drug effects KW - Streptococcus constellatus -- physiology KW - Eubacterium -- isolation & purification KW - Peptostreptococcus -- drug effects KW - Streptococcus constellatus -- drug effects KW - Streptococcus anginosus -- physiology KW - Streptococcus constellatus -- isolation & purification KW - Eubacterium -- physiology KW - Eubacterium -- drug effects KW - Microbial Viability -- drug effects KW - Veillonella -- physiology KW - Species Specificity KW - Peptostreptococcus -- physiology KW - Veillonella -- isolation & purification KW - Culture Media -- chemistry KW - Nitrosamines -- pharmacology KW - Microbiota -- drug effects KW - Complex Mixtures -- pharmacology KW - Microbiota -- physiology KW - Tobacco, Smokeless -- analysis KW - Mouth -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835495884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Effect+of+smokeless+tobacco+products+on+human+oral+bacteria+growth+and+viability.&rft.au=Liu%2C+Min%3BJin%2C+Jinshan%3BPan%2C+Hongmiao%3BFeng%2C+Jinhui%3BCerniglia%2C+Carl+E%3BYang%2C+Maocheng%3BChen%2C+Huizhong&rft.aulast=Liu&rft.aufirst=Min&rft.date=2016-12-01&rft.volume=42&rft.issue=&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=1095-8274&rft_id=info:doi/10.1016%2Fj.anaerobe.2016.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-16 N1 - Date created - 2016-10-19 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1016/j.anaerobe.2016.10.006 ER - TY - JOUR T1 - Health risk assessment of the intake of butyltin and phenyltin compounds from fish and seafood in Taiwanese population. AN - 1835358639; 27632793 AB - Organotin compounds have been applied as stabilizers for PVCs, fungicides, and pesticides, those can enter water systems through antifouling paints on ships as well as from diverse industrial and agricultural processes. This study aims to monitor the background levels of six organotins in 200 fishery products. In the current study, the high organotin levels are over tolerable average residue levels in Taiwan. Phenyltins (PTs) levels in fish and seafood are higher than butyltins (BTs). Risk assessment showed that 95% upper confidence limits of the hazard index (HI) of organotins were almost all over 1, indicating that there are probability of health impacts for organotin consumption in Taiwanese consumers. Those who consume higher amounts of seafood and fishery may be at a higher risk of health issues, but the data indicate that organotin levels have become controlled in recent years as compared with health risk data published in 2006. JF - Chemosphere AU - Lee, Ching-Chang AU - Hsu, Ya-Chen AU - Kao, Yi-Ting AU - Chen, Hsiu-Ling AD - Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, Tainan, Taiwan; Environmental Trace Toxic Substances Research Center, Medical College, National Cheng Kung University, Tainan, Taiwan. ; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, Taiwan. ; Institute of Occupational Safety and Hazard Prevention, Hung Kuang University, Taichung, Taiwan. Electronic address: hsiulin@sunrise.hk.edu.tw. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 568 EP - 575 VL - 164 KW - Risk assessment KW - Phenyltins KW - Tolerable average residue level KW - Organotins KW - Butyltins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835358639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Health+risk+assessment+of+the+intake+of+butyltin+and+phenyltin+compounds+from+fish+and+seafood+in+Taiwanese+population.&rft.au=Lee%2C+Ching-Chang%3BHsu%2C+Ya-Chen%3BKao%2C+Yi-Ting%3BChen%2C+Hsiu-Ling&rft.aulast=Lee&rft.aufirst=Ching-Chang&rft.date=2016-12-01&rft.volume=164&rft.issue=&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2016.08.141 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-15 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1016/j.chemosphere.2016.08.141 ER - TY - JOUR T1 - Effects of a 28-day dietary co-exposure to melamine and cyanuric acid on the levels of serum microRNAs in male and female Fisher 344 rats. AN - 1835001675; 27621052 AB - We showed previously that a 28-day combined dietary exposure to melamine and cyanuric acid (MEL&CYA) induced kidney lesions in NCTR Fisher 344 (F344) rats. Histopathological changes were significant in females dosed with ≥240 ppm MEL&CYA and in males dosed with ≥180 ppm MEL&CYA; however, the nephrotoxicity biomarkers blood urea nitrogen (BUN) and serum creatinine (SCr) were increased only by ≥240 ppm MEL&CYA. The serum miRNome has been reported to reflect toxicity of several organs, including the kidney. Here, we compared the dose-response of alterations in serum miRNAs to those of BUN, SCr, and kidney histopathology in rats co-exposed to MEL&CYA. The serum miRNome of male F344 rats dosed with 0, 180, or 240 ppm MEL&CYA was screened using quantitative real-time RT-PCR (qRT-PCR) and the levels of selected serum miRNAs were analyzed further in both sexes over the full dose range. The levels of several miRNAs were significantly reduced in rats treated with 240 ppm MEL&CYA versus control. In addition, miR-128-3p and miR-210-3p were decreased in males treated with 180pm MEL&CYA, a dose at which the levels of BUN and SCr were not yet affected by treatment. These data suggest that the serum miRNome is affected by nephrotoxic doses of MEL&CYA in male and female rats. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Silva, Camila S AU - Chang, Ching-Wei AU - Williams, Denita AU - Porter-Gill, Patricia AU - Gamboa da Costa, Gonçalo AU - Camacho, Luísa AD - Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: luisa.camacho@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 11 EP - 16 VL - 98 KW - SCr KW - Melamine KW - Kidney KW - Cyanuric acid KW - BUN KW - Serum miRNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835001675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=FDA+approval%3A+idelalisib+monotherapy+for+the+treatment+of+patients+with+follicular+lymphoma+and+small+lymphocytic+lymphoma.&rft.au=Miller%2C+Barry+W%3BPrzepiorka%2C+Donna%3Bde+Claro%2C+R+Angelo%3BLee%2C+Kyung%3BNie%2C+Lei%3BSimpson%2C+Natalie%3BGudi%2C+Ramadevi%3BSaber%2C+Haleh%3BShord%2C+Stacy%3BBullock%2C+Julie%3BMarathe%2C+Dhananjay%3BMehrotra%2C+Nitin%3BHsieh%2C+Li+Shan%3BGhosh%2C+Debasis%3BBrown%2C+Janice%3BKane%2C+Robert+C%3BJustice%2C+Robert%3BKaminskas%2C+Edvardas%3BFarrell%2C+Ann+T%3BPazdur%2C+Richard&rft.aulast=Miller&rft.aufirst=Barry&rft.date=2015-04-01&rft.volume=21&rft.issue=7&rft.spage=1525&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-2522 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.09.013 ER - TY - JOUR T1 - Chronic Health Conditions, Physical Activity and Dietary Behaviors of Bhutanese Refugees: A Houston-Based Needs Assessment AN - 1829718310 AB - Bhutanese refugees resettling in the U.S. face many challenges including several related to health and health care. Limited health literacy and the relatively complicated US health care system may contribute to health disparities as well. A health assessment was conducted on adult refugees in Houston, Texas to provide healthcare providers, community organizations, and stakeholders baseline data to plan programs and interventions. A convenience sample of 100 participants had a mean age of 38.37 years, 56 % where males, and almost 80 % did not have high school level education. High blood pressure (27 %), dizziness (27 %), and arthritis (22 %) were the commonly identified chronic health conditions and trouble concentrating (34 %) and fatigue (37 %) were also reported. Sixty-two percent of the respondents reported that they consume recommended servings of fruits and vegetables and 41 %reported that they were currently getting at least 20-30 min of aerobic exercise per day. The assessment concluded with recommendations on how better provide care and services for the refugees. JF - Journal of Immigrant and Minority Health AU - Misra, Sanghamitra M AU - Nepal, Vishnu P AU - Banerjee, Deborah AU - Giardino, Angelo P AD - Academic General Pediatrics, Baylor College of Medicine, Houston, TX, USA; Pediatrics, Texas Children's Hospital, Houston, TX, USA ; Department of Health and Human Services, City of Houston, Houston, TX, USA ; Academic General Pediatrics, Baylor College of Medicine, Houston, TX, USA; Pediatrics, Texas Children's Hospital, Houston, TX, USA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 1423 EP - 1431 CY - New York PB - Springer Science & Business Media VL - 18 IS - 6 SN - 1557-1912 KW - Medical Sciences KW - Refugees KW - Bhutanese KW - Needs assessment KW - Healthy food KW - Hypertension KW - Vegetables KW - Physical activity KW - Assessment KW - Health inequalities KW - Fatigue KW - Arthritis KW - Health education KW - Literacy KW - Community organizations KW - Dizziness KW - Health status KW - Men KW - Chronic sickness KW - Health care industry KW - Blood pressure KW - Aerobic exercise KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1829718310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Chronic+Health+Conditions%2C+Physical+Activity+and+Dietary+Behaviors+of+Bhutanese+Refugees%3A+A+Houston-Based+Needs+Assessment&rft.au=Misra%2C+Sanghamitra+M%3BNepal%2C+Vishnu+P%3BBanerjee%2C+Deborah%3BGiardino%2C+Angelo+P&rft.aulast=Misra&rft.aufirst=Sanghamitra&rft.date=2016-12-01&rft.volume=18&rft.issue=6&rft.spage=1423&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-015-0282-1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-10-18 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1007/s10903-015-0282-1 ER - TY - JOUR T1 - Sensitive detection of influenza viruses with Europium nanoparticles on an epoxy silica sol-gel functionalized polycarbonate-polydimethylsiloxane hybrid microchip AN - 1827908065; PQ0003662347 AB - In an effort to develop new tools for diagnosing influenza in resource-limited settings, we fabricated a polycarbonate (PC)-polydimethylsiloxane (PDMS) hybrid microchip using a simple epoxy silica sol-gel coating/bonding method and employed it in sensitive detection of influenza virus with Europium nanoparticles (EuNPs). The incorporation of sol-gel material in device fabrication provided functionalized channel surfaces ready for covalent immobilization of primary antibodies and a strong bonding between PDMS substrates and PC supports without increasing background fluorescence. In microchip EuNP immunoassay ( mu ENIA) of inactivated influenza viruses, replacing native PDMS microchips with hybrid microchips allowed the achievement of a 6-fold increase in signal-to-background ratio, a 12-fold and a 6-fold decreases in limit-of-detection (LOD) in influenza A and B tests respectively. Using influenza A samples with known titers, the LOD of influenza mu ENIA on hybrid microchips was determined to be ~104 TCID50 titer/mL and 103-104 EID50 titer/mL. A comparison test indicated that the sensitivity of influenza mu ENIA enhanced using the hybrid microchips even surpassed that of a commercial laboratory influenza ELISA test. In addition to the sensitivity improvement, assay variation was clearly reduced when hybrid microchips instead of native PDMS microchips were used in the mu ENIA tests. Finally, infectious reference viruses and nasopharyngeal swab patient specimens were successfully tested using mu ENIA on hybrid microchip platforms, demonstrating the potential of this unique microchip nanoparticle assay in clinical diagnosis of influenza. Meanwhile, the tests showed the necessity of using nucleic acid confirmatory tests to clarify ambiguous test results obtained from prototype or developed point-of-care testing devices for influenza diagnosis. JF - Biosensors and Bioelectronics AU - Liu, Jikun AU - Zhao, Jiangqin AU - Petrochenko, Peter AU - Zheng, Jiwen AU - Hewlett, Indira AD - Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, United States Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 150 EP - 155 PB - Elsevier B.V., 660 White Plains Rd. Tarrytown NY 10591-5153 United States VL - 86 SN - 0956-5663, 0956-5663 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Influenza KW - Europium nanoparticle KW - Immunoassay KW - Sol-gel coating KW - Surface functionalization KW - Lab-on-a-chip KW - Enzyme-linked immunosorbent assay KW - Fluorescence KW - Influenza A KW - Biosensors KW - Antibodies KW - Influenza virus KW - nucleic acids KW - Silica KW - Hybrids KW - microchips KW - Immunoassays KW - nanoparticles KW - Immobilization KW - polycarbonate KW - Coatings KW - W 30955:Biosensors KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827908065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=Sensitive+detection+of+influenza+viruses+with+Europium+nanoparticles+on+an+epoxy+silica+sol-gel+functionalized+polycarbonate-polydimethylsiloxane+hybrid+microchip&rft.au=Liu%2C+Jikun%3BZhao%2C+Jiangqin%3BPetrochenko%2C+Peter%3BZheng%2C+Jiwen%3BHewlett%2C+Indira&rft.aulast=Liu&rft.aufirst=Jikun&rft.date=2016-12-01&rft.volume=86&rft.issue=&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2016.06.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Fluorescence; Influenza A; Biosensors; Antibodies; Silica; nucleic acids; Hybrids; microchips; nanoparticles; Immunoassays; polycarbonate; Immobilization; Coatings; Influenza virus DO - http://dx.doi.org/10.1016/j.bios.2016.06.044 ER - TY - JOUR T1 - Literature information in PubChem: associations between PubChem records and scientific articles AN - 1827902115; PQ0003731662 AB - PubChem is an open archive consisting of a set of three primary public databases (BioAssay, Compound, and Substance). It contains information on a broad range of chemical entities, including small molecules, lipids, carbohydrates, and (chemically modified) amino acid and nucleic acid sequences (including siRNA and miRNA). Currently (as of Nov. 2015), PubChem contains more than 150 million depositor-provided chemical substance descriptions, 60 million unique chemical structures, and 225 million biological activity test results provided from over 1 million biological assay records. Many PubChem records (substances, compounds, and assays) include depositor-provided cross-references to scientific articles in PubMed. Some PubChem contributors provide bioactivity data extracted from scientific articles. Literature-derived bioactivity data complement high-throughput screening (HTS) data from the concluded NIH Molecular Libraries Program and other HTS projects. Some journals provide PubChem with information on chemicals that appear in their newly published articles, enabling concurrent publication of scientific articles in journals and associated data in public databases. In addition, PubChem links records to PubMed articles indexed with the Medical Subject Heading (MeSH) controlled vocabulary thesaurus. Literature information, both provided by depositors and derived from MeSH annotations, can be accessed using PubChem's web interfaces, enabling users to explore information available in literature related to PubChem records beyond typical web search results. [Figure not available: see fulltext.] JF - Journal of Cheminformatics AU - Kim, Sunghwan AU - Thiessen, Paul A AU - Cheng, Tiejun AU - Yu, Bo AU - Shoemaker, Benjamin A AU - Wang, Jiyao AU - Bolton, Evan E AU - Wang, Yanli AU - Bryant, Stephen H AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD, 20894, USA, kimsungh@ncbi.nlm.nih.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1 EP - 15 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 8 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Computer programs KW - Data processing KW - nucleic acids KW - siRNA KW - Informatics KW - Lipids KW - miRNA KW - high-throughput screening KW - Carbohydrates KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827902115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cheminformatics&rft.atitle=Literature+information+in+PubChem%3A+associations+between+PubChem+records+and+scientific+articles&rft.au=Kim%2C+Sunghwan%3BThiessen%2C+Paul+A%3BCheng%2C+Tiejun%3BYu%2C+Bo%3BShoemaker%2C+Benjamin+A%3BWang%2C+Jiyao%3BBolton%2C+Evan+E%3BWang%2C+Yanli%3BBryant%2C+Stephen+H&rft.aulast=Kim&rft.aufirst=Sunghwan&rft.date=2016-12-01&rft.volume=8&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cheminformatics&rft.issn=1758-2946&rft_id=info:doi/10.1186%2Fs13321-016-0142-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 31 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; nucleic acids; Data processing; siRNA; Informatics; Lipids; miRNA; high-throughput screening; Carbohydrates DO - http://dx.doi.org/10.1186/s13321-016-0142-6 ER - TY - JOUR T1 - Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure. AN - 1826715716; 27371368 AB - Furan, a rodent liver carcinogen, is a chemical contaminant found in a broad range of cooked foods. Despite a lack of conclusive evidence regarding furan genotoxicity, several reports indicate that furan induces a broad range of non-genotoxic alterations, including aberrant expression microRNAs (miRNAs). In order to clarify the role of miRNA alterations with respect to furan carcinogenicity, we investigated the expression of several cancer-related miRNAs in the livers of Fischer 344 rats treated continuously with furan. The results demonstrate that furan induced marked changes in miRNA expression, characterized by over-expression of hepatic miRNAs, miR-34a, miR-93, miR-200a, miR-200b, and miR-224, and down-regulation of miR-375. Interestingly, a majority of furan-induced miRNA changes diminished after the cessation of the furan treatment. In contrast, the expression of miR-375 steadily decreased in a time-dependent manner following furan treatment. The reduced expression of miR-375 was accompanied by cytosine DNA hypermethylation and increased lysine methylation of histone H3K9 and H3K27 at the MiR-375 gene. The significance of miR-375 inhibition with respect to the pathogenesis of furan-induced liver toxicity and carcinogenicity may be attributed to its role in the up-regulation of Yes-associated protein 1 (YAP1), which is one of the principal events in the liver carcinogenesis. The results of the present study support the hypothesis of the non-genotoxic mode of action of furan and emphasize the importance of epigenetic alterations in the mechanism of furan hepatotoxicity. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - de Conti, Aline AU - Tryndyak, Volodymyr AU - Doerge, Daniel R AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA. Electronic address: igor.pogribny@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 2 EP - 10 VL - 98 KW - Liver cancer KW - Furan KW - miR-375 KW - Epigenetic KW - miRNAs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826715716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chirality&rft.atitle=Chiral+resolution+and+absolute+configuration+of+the+enantiomers+of+the+psychoactive+%22designer+drug%22+3%2C4-methylenedioxypyrovalerone.&rft.au=Suzuki%2C+Masaki%3BDeschamps%2C+Jeffrey+R%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Suzuki&rft.aufirst=Masaki&rft.date=2015-04-01&rft.volume=27&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Chirality&rft.issn=1520-636X&rft_id=info:doi/10.1002%2Fchir.22423 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.06.027 ER - TY - JOUR T1 - MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. AN - 1826677374; 27157613 AB - ErbB-2 amplification/overexpression accounts for an aggressive breast cancer (BC) subtype (ErbB-2-positive). Enhanced ErbB-2 expression was also found in gastric cancer (GC) and has been correlated with poor clinical outcome. The ErbB-2-targeted therapies trastuzumab (TZ), a monoclonal antibody, and lapatinib, a tyrosine kinase inhibitor, have proved highly beneficial. However, resistance to such therapies remains a major clinical challenge. We here revealed a novel mechanism underlying the antiproliferative effects of both agents in ErbB-2-positive BC and GC. TZ and lapatinib ability to block extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase (PI3K)/AKT in sensitive cells inhibits c-Myc activation, which results in upregulation of miR-16. Forced expression of miR-16 inhibited in vitro proliferation in BC and GC cells, both sensitive and resistant to TZ and lapatinib, as well as in a preclinical BC model resistant to these agents. This reveals miR-16 role as tumor suppressor in ErbB-2-positive BC and GC. Using genome-wide expression studies and miRNA target prediction algorithms, we identified cyclin J and far upstream element-binding protein 1 (FUBP1) as novel miR-16 targets, which mediate miR-16 antiproliferative effects. Supporting the clinical relevance of our results, we found that high levels of miR-16 and low or null FUBP1 expression correlate with TZ response in ErbB-2-positive primary BCs. These findings highlight a potential role of miR-16 and FUBP1 as biomarkers of sensitivity to TZ therapy. Furthermore, we revealed miR-16 as an innovative therapeutic agent for TZ- and lapatinib-resistant ErbB-2-positive BC and GC. JF - Oncogene AU - Venturutti, L AU - Cordo Russo, R I AU - Rivas, M A AU - Mercogliano, M F AU - Izzo, F AU - Oakley, R H AU - Pereyra, M G AU - De Martino, M AU - Proietti, C J AU - Yankilevich, P AU - Roa, J C AU - Guzmán, P AU - Cortese, E AU - Allemand, D H AU - Huang, T H AU - Charreau, E H AU - Cidlowski, J A AU - Schillaci, R AU - Elizalde, P V AD - Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina. ; Department of Medicine, Weill Cornell Medicine, New York, NY, USA. ; Department of Health and Human Services, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. ; Instituto de Investigación en Biomedicina de Buenos Aires, CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina. ; Departamento de Anatomía Patológica (BIOREN), Universidad de La Frontera, Temuco, Chile. ; Servicio de Ginecología, Hospital Aeronáutico Central, Buenos Aires, Argentina. ; Unidad de Patología Mamaria, Hospital General de Agudos 'Juan A Fernández', Buenos Aires, Argentina. ; Department of Molecular Medicine/Institute of Biotechnology, Cancer Therapy and Research Center, University of Texas, San Antonio, TX, USA. Y1 - 2016/12/01/ PY - 2016 DA - 2016 Dec 01 SP - 6189 EP - 6202 VL - 35 IS - 48 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826677374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=MiR-16+mediates+trastuzumab+and+lapatinib+response+in+ErbB-2-positive+breast+and+gastric+cancer+via+its+novel+targets+CCNJ+and+FUBP1.&rft.au=Venturutti%2C+L%3BCordo+Russo%2C+R+I%3BRivas%2C+M+A%3BMercogliano%2C+M+F%3BIzzo%2C+F%3BOakley%2C+R+H%3BPereyra%2C+M+G%3BDe+Martino%2C+M%3BProietti%2C+C+J%3BYankilevich%2C+P%3BRoa%2C+J+C%3BGuzm%C3%A1n%2C+P%3BCortese%2C+E%3BAllemand%2C+D+H%3BHuang%2C+T+H%3BCharreau%2C+E+H%3BCidlowski%2C+J+A%3BSchillaci%2C+R%3BElizalde%2C+P+V&rft.aulast=Venturutti&rft.aufirst=L&rft.date=2016-12-01&rft.volume=35&rft.issue=48&rft.spage=6189&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2016.151 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/onc.2016.151 ER - TY - JOUR T1 - Reproductive history and risk of colorectal adenocarcinoma in parous women: a Nordic population-based case-control study. AN - 1835379465; 27701386 AB - Data are conflicting regarding the role of endogenous sex hormones in colorectal carcinogenesis. In this large population-based study, we pooled data from birth and cancer registries in four Nordic countries, to evaluate the risk of colorectal adenocarcinoma in relation to women's reproductive history. We conducted a population-based case-control study among women registered in Nordic birth registries. The study included colorectal adenocarcinoma cases diagnosed in Denmark, Finland, Norway, and Sweden during 1967-2013 and up to 10 matched controls per case, in total 22 185 cases and 220 246 controls. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were derived from conditional logistic regression models. We had limited information available on possible confounders. We found no evidence for associations between colorectal adenocarcinoma and parity, age at first and last birth, and time since first and last birth. The risk estimates were also close to unity for specific cancer subsites (proximal and distal colon and rectum). As well, when the analyses were stratified on menopausal status, parity, and mother's year of birth, no indication of associations was found. In this large, Nordic population-based study, no evidence for associations was found between women's reproductive history and colorectal adenocarcinoma in parous women. JF - British journal of cancer AU - Bjørge, Tone AU - Gissler, Mika AU - Ording, Anne Gulbech AU - Engeland, Anders AU - Glimelius, Ingrid AU - Leinonen, Maarit AU - Sørensen, Henrik Toft AU - Tretli, Steinar AU - Ekbom, Anders AU - Troisi, Rebecca AU - Grotmol, Tom AD - Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. ; National Institute for Health and Welfare (THL), Helsinki, Finland. ; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. ; Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. ; Cancer Society of Finland, Finnish Cancer Registry, Helsinki, Finland. ; Cancer Registry of Norway, Oslo, Norway. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2016/11/22/ PY - 2016 DA - 2016 Nov 22 SP - 1416 EP - 1420 VL - 115 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835379465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Reproductive+history+and+risk+of+colorectal+adenocarcinoma+in+parous+women%3A+a+Nordic+population-based+case-control+study.&rft.au=Bj%C3%B8rge%2C+Tone%3BGissler%2C+Mika%3BOrding%2C+Anne+Gulbech%3BEngeland%2C+Anders%3BGlimelius%2C+Ingrid%3BLeinonen%2C+Maarit%3BS%C3%B8rensen%2C+Henrik+Toft%3BTretli%2C+Steinar%3BEkbom%2C+Anders%3BTroisi%2C+Rebecca%3BGrotmol%2C+Tom&rft.aulast=Bj%C3%B8rge&rft.aufirst=Tone&rft.date=2016-11-22&rft.volume=115&rft.issue=11&rft.spage=1416&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fbjc.2016.315 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/bjc.2016.315 ER - TY - JOUR T1 - Assessing the reliability of ecotoxicological studies: An overview of current needs and approaches. AN - 1842550464; 27869364 AB - In general, reliable studies are well designed and well performed, and enough details on study design and performance are reported to assess the study. For hazard and risk assessment in various legal frameworks, many different types of ecotoxicity studies need to be evaluated for reliability. These studies vary in study design, methodology, quality, and level of detail reported (e.g., reviews, peer-reviewed research papers, or industry-sponsored studies documented under Good Laboratory Practice [GLP] guidelines). Regulators have the responsibility to make sound and verifiable decisions and should evaluate each study for reliability in accordance with scientific principles regardless of whether they were conducted in accordance with GLP and/or standardized methods. Thus, a systematic and transparent approach is needed to evaluate studies for reliability. In this paper, 8 different methods for reliability assessment were compared using a number of attributes: categorical versus numerical scoring methods, use of exclusion and critical criteria, weighting of criteria, whether methods are tested with case studies, domain of applicability, bias toward GLP studies, incorporation of standard guidelines in the evaluation method, number of criteria used, type of criteria considered, and availability of guidance material. Finally, some considerations are given on how to choose a suitable method for assessing reliability of ecotoxicity studies. Integr Environ Assess Manag. ©2016 SETAC. © 2016 SETAC. JF - Integrated environmental assessment and management AU - Moermond, Caroline AU - Beasley, Amy AU - Breton, Roger AU - Junghans, Marion AU - Laskowski, Ryszard AU - Solomon, Keith AU - Zahner, Holly AD - Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. ; The Dow Chemical Company, Toxicology and Environmental Research and Consulting, Midland, Michigan, USA. ; Intrinsik, Ottawa, Ontario, Canada. ; Swiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland. ; Institute of Environmental Sciences, Jagiellonian University, Kraków, Poland. ; Centre for Toxicology, School of Environmental Science, University of Guelph, Guelph, Ontario, Canada. ; US Food and Drug Administration, Center for Veterinary Medicine, Rockville, Maryland. Y1 - 2016/11/21/ PY - 2016 DA - 2016 Nov 21 KW - Risk assessment KW - Quality evaluation KW - Literature evaluation KW - Reliability assessment KW - Hazard assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842550464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Assessing+the+reliability+of+ecotoxicological+studies%3A+An+overview+of+current+needs+and+approaches.&rft.au=Moermond%2C+Caroline%3BBeasley%2C+Amy%3BBreton%2C+Roger%3BJunghans%2C+Marion%3BLaskowski%2C+Ryszard%3BSolomon%2C+Keith%3BZahner%2C+Holly&rft.aulast=Moermond&rft.aufirst=Caroline&rft.date=2016-11-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1870 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-21 N1 - Date revised - 2017-01-31 N1 - Last updated - 2017-01-31 DO - http://dx.doi.org/10.1002/ieam.1870 ER - TY - JOUR T1 - A mechanistic investigation of thrombotic microangiopathy associated with intravenous abuse of Opana ER. AN - 1841799803; 27864296 AB - Since 2012, a number of case reports have described the occurrence of thrombotic microangiopathy (TMA) following intravenous abuse of extended release oxymorphone hydrochloride (Opana ER), an oral opioid for long-term treatment of chronic pain. Here, we present unique clinical features of three patients and investigate intravenous exposure to the tablet's inert ingredients as a possible causal mechanism. Guinea pigs were used as an animal model to understand the hematopathologic and nephrotoxic potential of the inert ingredient mixture (termed here as PEO+) which primarily contains high molecular weight polyethylene oxide (HMW PEO). Microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury were found in a group of three patients following recent injection of adulterated extended release oxymorphone tablets. Varying degrees of cardiac involvement and retinal ischemia occurred, with TMA evident on kidney biopsy. A TMA-like state also developed in guinea pigs intravenously administered PEO+. Acute tubular and glomerular renal injury was accompanied by non-heme iron deposition and hypoxia inducible factor-1 alpha upregulation in the renal cortex. Similar outcomes were observed following dosing with HMW PEO alone. Intravenous exposure to the inert ingredients in reformulated extended release oxymorphone can elicit thrombotic microangiopathy. While prescription opioid abuse shows geographic variation, all physicians should be highly inquisitive of intravenous drug abuse when presented with cases of thrombotic microangiopathy. Copyright © 2016 American Society of Hematology. JF - Blood AU - Hunt, Ryan AU - Yalamanoglu, Ayla AU - Tumlin, James AU - Schiller, Tal AU - Baek, Jin Hyen AU - Wu, Andrew AU - Fogo, Agnes B AU - Yang, Haichun AU - Wong, Edward AU - Miller, Peter AU - Buehler, Paul W AU - Kimchi-Sarfaty, Chava AD - Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, United States. ; Division of Blood Components and Devices, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, United States. ; Department of Internal Medicine, University of Tennessee College of Medicine at Chattanooga, Chattanooga, TN, United States. ; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. ; Departments of Pediatrics and Pathology, George Washington School of Medicine and Health Sciences, Washington, DC, United States. ; Dept. of Internal Medicine, Section on Hematology and Oncology; Section on Pulmonary, Critical Care, Allergy and Immunology; Department of Anesthesiology, Section on Critical Care Medicine, Wake Forest, Winston-Salem, NC, United States. ; Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, United States; chava.kimchi-sarfaty@fda.hhs.gov. Y1 - 2016/11/18/ PY - 2016 DA - 2016 Nov 18 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1841799803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=A+mechanistic+investigation+of+thrombotic+microangiopathy+associated+with+intravenous+abuse+of+Opana+ER.&rft.au=Hunt%2C+Ryan%3BYalamanoglu%2C+Ayla%3BTumlin%2C+James%3BSchiller%2C+Tal%3BBaek%2C+Jin+Hyen%3BWu%2C+Andrew%3BFogo%2C+Agnes+B%3BYang%2C+Haichun%3BWong%2C+Edward%3BMiller%2C+Peter%3BBuehler%2C+Paul+W%3BKimchi-Sarfaty%2C+Chava&rft.aulast=Hunt&rft.aufirst=Ryan&rft.date=2016-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials-Response AN - 1846407496; PQ0003881684 JF - Clinical Cancer Research AU - Kluetz, Paul G AU - Papadopoulos, Elektra J AU - Johnson, Laura Lee AU - Donoghue, Martha AU - Kwitkowski, Virginia E AU - Chen, Wen-Hung AU - Sridhara, Rajeshwari AU - Farrell, Ann T AU - Keegan, Patricia AU - Kim, Geoffrey AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, paul.kluetz@fda.hhs.gov Y1 - 2016/11/15/ PY - 2016 DA - 2016 Nov 15 SP - 5618 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 22 IS - 22 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846407496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Focusing+on+Core+Patient-Reported+Outcomes+in+Cancer+Clinical+Trials-Response&rft.au=Kluetz%2C+Paul+G%3BPapadopoulos%2C+Elektra+J%3BJohnson%2C+Laura+Lee%3BDonoghue%2C+Martha%3BKwitkowski%2C+Virginia+E%3BChen%2C+Wen-Hung%3BSridhara%2C+Rajeshwari%3BFarrell%2C+Ann+T%3BKeegan%2C+Patricia%3BKim%2C+Geoffrey%3BPazdur%2C+Richard&rft.aulast=Kluetz&rft.aufirst=Paul&rft.date=2016-11-15&rft.volume=22&rft.issue=22&rft.spage=5618&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-16-2140 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-07 DO - http://dx.doi.org/10.1158/1078-0432.CCR-16-2140 ER - TY - JOUR T1 - Magnetic resonance spectroscopic analysis of neurometabolite changes in the developing rat brain at 7T. AN - 1835688591; 27663970 AB - We utilized proton magnetic resonance spectroscopy to evaluate the metabolic profile of the hippocampus and anterior cingulate cortex of the developing rat brain from postnatal days 14-70. Measured metabolite concentrations were modeled using linear, exponential, or logarithmic functions and the time point at which the data reached plateau (i.e. when the portion of the data could be fit to horizontal line) was estimated and was interpreted as the time when the brain has reached maturity with respect to that metabolite. N-acetyl-aspartate and myo-inositol increased within the observed period. Gluthathione did not vary significantly, while taurine decreased initially and then stabilized. Phosphocreatine and total creatine had a tendency to increase towards the end of the experiment. Some differences between our data and the published literature were observed in the concentrations and dynamics of phosphocreatine, myo-inositol, and GABA in the hippocampus and creatine, GABA, glutamine, choline and N-acetyl-aspartate in the cortex. Such differences may be attributed to experimental conditions, analysis approaches and animal species. The latter is supported by differences between in-house rat colony and rats from Charles River Labs. Spectroscopy provides a valuable tool for non-invasive brain neurochemical profiling for use in developmental neurobiology research. Special attention needs to be paid to important sources of variation like animal strain and commercial source. Published by Elsevier B.V. JF - Brain research AU - Ramu, Jaivijay AU - Konak, Tetyana AU - Liachenko, Serguei AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. ; Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. Electronic address: Serguei.liachenko@fda.hhs.gov. Y1 - 2016/11/15/ PY - 2016 DA - 2016 Nov 15 SP - 114 EP - 120 VL - 1651 KW - Rat KW - Neurometabolite KW - Magnetic resonance spectroscopy KW - Developmental neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835688591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Magnetic+resonance+spectroscopic+analysis+of+neurometabolite+changes+in+the+developing+rat+brain+at+7T.&rft.au=Ramu%2C+Jaivijay%3BKonak%2C+Tetyana%3BLiachenko%2C+Serguei&rft.aulast=Ramu&rft.aufirst=Jaivijay&rft.date=2016-11-15&rft.volume=1651&rft.issue=&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2016.09.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.brainres.2016.09.028 ER - TY - JOUR T1 - In Vitro Toxicity Evaluation of Lignin-(Un)coated Cellulose Based Nanomaterials on Human A549 and THP-1 Cells. AN - 1835405437; 27709894 AB - A significant amount of research toward commercial development of cellulose based nanomaterials (CNM) is now in progress with some potential applications. Using human A549 and THP-1 cells, we evaluated the biological responses of various CNMs, made out of similar material but with functional and morphological variations. While A549 cells displayed minimal or no cytotoxic responses following exposure to CNMs, THP-1 cells were more susceptible to cytotoxicity, cellular damage and inflammatory responses. Further analysis of these biological responses evaluated using hierarchical clustering approaches was effective in discriminating (dis)-similarities of various CNMs studied and identified potential inflammatory factors contributing to cytotoxicity. No correlation between cytotoxicity and surface properties of CNMs was found. This study clearly highlights that, in addition to the source and characteristics of CNMs, cell type-specific differences in the recognition/uptake of CNMs along with their inherent capability to respond to external stimuli are crucial for assessing the toxicity of CNMs. JF - Biomacromolecules AU - Yanamala, Naveena AU - Kisin, Elena R AU - Menas, Autumn L AU - Farcas, Mariana T AU - Khaliullin, Timur O AU - Vogel, Ulla B AU - Shurin, Galina V AU - Schwegler-Berry, Diane AU - Fournier, Philip M AU - Star, Alexander AU - Shvedova, Anna A AD - Exposure Assessment Branch/NIOSH/CDC, Morgantown, West Virginia 26505, United States. ; National Research Centre for the Working Environment , Copenhagen DK-2100, Denmark. ; Department of Pathology, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania 15213, United States. ; Pathology & Physiology Research Branch/NIOSH/CDC, Morgantown, West Virginia 26505, United States. ; Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15213, United States. Y1 - 2016/11/14/ PY - 2016 DA - 2016 Nov 14 SP - 3464 EP - 3473 VL - 17 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835405437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomacromolecules&rft.atitle=In+Vitro+Toxicity+Evaluation+of+Lignin-%28Un%29coated+Cellulose+Based+Nanomaterials+on+Human+A549+and+THP-1+Cells.&rft.au=Yanamala%2C+Naveena%3BKisin%2C+Elena+R%3BMenas%2C+Autumn+L%3BFarcas%2C+Mariana+T%3BKhaliullin%2C+Timur+O%3BVogel%2C+Ulla+B%3BShurin%2C+Galina+V%3BSchwegler-Berry%2C+Diane%3BFournier%2C+Philip+M%3BStar%2C+Alexander%3BShvedova%2C+Anna+A&rft.aulast=Yanamala&rft.aufirst=Naveena&rft.date=2016-11-14&rft.volume=17&rft.issue=11&rft.spage=3464&rft.isbn=&rft.btitle=&rft.title=Biomacromolecules&rft.issn=1526-4602&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Myofibroblasts and lung fibrosis induced by carbon nanotube exposure. AN - 1836734631; 27814727 AB - Carbon nanotubes (CNTs) are newly developed materials with unique properties and a range of industrial and commercial applications. A rapid expansion in the production of CNT materials may increase the risk of human exposure to CNTs. Studies in rodents have shown that certain forms of CNTs are potent fibrogenic inducers in the lungs to cause interstitial, bronchial, and pleural fibrosis characterized by the excessive deposition of collagen fibers and the scarring of involved tissues. The cellular and molecular basis underlying the fibrotic response to CNT exposure remains poorly understood. Myofibroblasts are a major type of effector cells in organ fibrosis that secrete copious amounts of extracellular matrix proteins and signaling molecules to drive fibrosis. Myofibroblasts also mediate the mechano-regulation of fibrotic matrix remodeling via contraction of their stress fibers. Recent studies reveal that exposure to CNTs induces the differentiation of myofibroblasts from fibroblasts in vitro and stimulates pulmonary accumulation and activation of myofibroblasts in vivo. Moreover, mechanistic analyses provide insights into the molecular underpinnings of myofibroblast differentiation and function induced by CNTs in the lungs.In view of the apparent fibrogenic activity of CNTs and the emerging role of myofibroblasts in the development of organ fibrosis, we discuss recent findings on CNT-induced lung fibrosis with emphasis on the role of myofibroblasts in the pathologic development of lung fibrosis. Particular attention is given to the formation and activation of myofibroblasts upon CNT exposure and the possible mechanisms by which CNTs regulate the function and dynamics of myofibroblasts in the lungs. It is evident that a fundamental understanding of the myofibroblast and its function and regulation in lung fibrosis will have a major influence on the future research on the pulmonary response to nano exposure, particle and fiber-induced pneumoconiosis, and other human lung fibrosing diseases. JF - Particle and fibre toxicology AU - Dong, Jie AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV, USA. ; Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV, USA. qam1@cdc.gov. Y1 - 2016/11/04/ PY - 2016 DA - 2016 Nov 04 SP - 60 VL - 13 IS - 1 KW - Myofibroblast KW - Mechanism KW - Extracellular matrix KW - Carbon nanotube KW - Lung fibrosis KW - Animal model UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1836734631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Myofibroblasts+and+lung+fibrosis+induced+by+carbon+nanotube+exposure.&rft.au=Dong%2C+Jie%3BMa%2C+Qiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2016-11-04&rft.volume=13&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer. AN - 1826672972; 27132513 AB - The Cancer Genome Atlas (TCGA) network study of 12 cancer types (PanCancer 12) revealed frequent mutation of TP53, and amplification and expression of related TP63 isoform ΔNp63 in squamous cancers. Further, aberrant expression of inflammatory genes and TP53/p63/p73 targets were detected in the PanCancer 12 project, reminiscent of gene programs comodulated by cREL/ΔNp63/TAp73 transcription factors we uncovered in head and neck squamous cell carcinomas (HNSCCs). However, how inflammatory gene signatures and cREL/p63/p73 targets are comodulated genome wide is unclear. Here, we examined how the inflammatory factor tumor necrosis factor-α (TNF-α) broadly modulates redistribution of cREL with ΔNp63α/TAp73 complexes and signatures genome wide in the HNSCC model UM-SCC46 using chromatin immunoprecipitation sequencing (ChIP-seq). TNF-α enhanced genome-wide co-occupancy of cREL with ΔNp63α on TP53/p63 sites, while unexpectedly promoting redistribution of TAp73 from TP53 to activator protein-1 (AP-1) sites. cREL, ΔNp63α and TAp73 binding and oligomerization on NF-κB-, TP53- or AP-1-specific sequences were independently validated by ChIP-qPCR (quantitative PCR), oligonucleotide-binding assays and analytical ultracentrifugation. Function of the binding activity was confirmed using TP53-, AP-1- and NF-κB-specific REs or p21, SERPINE1 and IL-6 promoter luciferase reporter activities. Concurrently, TNF-α regulated a broad gene network with cobinding activities for cREL, ΔNp63α and TAp73 observed upon array profiling and reverse transcription-PCR. Overlapping target gene signatures were observed in squamous cancer subsets and in inflamed skin of transgenic mice overexpressing ΔNp63α. Furthermore, multiple target genes identified in this study were linked to TP63 and TP73 activity and increased gene expression in large squamous cancer samples from PanCancer 12 TCGA by CircleMap. PARADIGM inferred pathway analysis revealed the network connection of TP63 and NF-κB complexes through an AP-1 hub, further supporting our findings. Thus, inflammatory cytokine TNF-α mediates genome-wide redistribution of the cREL/p63/p73, and AP-1 interactome, to diminish TAp73 tumor suppressor function and reciprocally activate NF-κB and AP-1 gene programs implicated in malignancy. JF - Oncogene AU - Si, H AU - Lu, H AU - Yang, X AU - Mattox, A AU - Jang, M AU - Bian, Y AU - Sano, E AU - Viadiu, H AU - Yan, B AU - Yau, C AU - Ng, S AU - Lee, S K AU - Romano, R-A AU - Davis, S AU - Walker, R L AU - Xiao, W AU - Sun, H AU - Wei, L AU - Sinha, S AU - Benz, C C AU - Stuart, J M AU - Meltzer, P S AU - Van Waes, C AU - Chen, Z AD - Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA. ; Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA. ; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Circuito Exterior, Ciudad Universitaria, Mexico City, MÉXICO. ; LKS Faculty of Medicine and School of Biomedical Sciences, LKS Faculty of Medicine and Center of Genome Sciences, The University of Hong Kong, Hong Kong, China. ; Buck Institute for Research on Aging, Novato, CA, USA. ; Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA. ; Department of Biochemistry, State University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences, Buffalo, New York, USA. ; Cancer Genetics Branch, National Cancer Institute, Bethesda, Maryland, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AK, USA. ; Biodata Mining and Discovery Section, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA. ; Clinical Immunology Section, National Eye Institute, NIH, Bethesda, Maryland, USA. Y1 - 2016/11/03/ PY - 2016 DA - 2016 Nov 03 SP - 5781 EP - 5794 VL - 35 IS - 44 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826672972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=TNF-%CE%B1+modulates+genome-wide+redistribution+of+%CE%94Np63%CE%B1%2FTAp73+and+NF-%CE%BAB+cREL+interactive+binding+on+TP53+and+AP-1+motifs+to+promote+an+oncogenic+gene+program+in+squamous+cancer.&rft.au=Si%2C+H%3BLu%2C+H%3BYang%2C+X%3BMattox%2C+A%3BJang%2C+M%3BBian%2C+Y%3BSano%2C+E%3BViadiu%2C+H%3BYan%2C+B%3BYau%2C+C%3BNg%2C+S%3BLee%2C+S+K%3BRomano%2C+R-A%3BDavis%2C+S%3BWalker%2C+R+L%3BXiao%2C+W%3BSun%2C+H%3BWei%2C+L%3BSinha%2C+S%3BBenz%2C+C+C%3BStuart%2C+J+M%3BMeltzer%2C+P+S%3BVan+Waes%2C+C%3BChen%2C+Z&rft.aulast=Si&rft.aufirst=H&rft.date=2016-11-03&rft.volume=35&rft.issue=44&rft.spage=5781&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2016.112 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/onc.2016.112 ER - TY - JOUR T1 - Rapid detection of bacterial endotoxins in ophthalmic viscosurgical device materials by direct analysis in real time mass spectrometry. AN - 1835524679; 27769383 AB - Bacterial endotoxins are lipopolysaccharides bound to the bacterial cell wall and released when bacteria rupture or disintegrate. Possible contamination of endotoxin in ophthalmic devices can cause a painful eye inflammation or result in toxic anterior segment syndrome after cataract surgery. Measurement of bacterial endotoxin in medical device materials is difficult since endotoxin binds with polymer matrix and some of the materials are very viscous and non-water soluble, where traditional enzyme-based Limulus amebocyte lysate (LAL) assay cannot be applied. Here we propose a rapid and high throughput ambient ionization mass spectrometric (MS) method using direct analysis in real time (DART) for the evaluation of endotoxin contamination in medical device materials. Large and structurally complex endotoxin instantaneously breaks down into low-mass characteristic fragment ions using DART and is detected by MS in both positive and negative ion modes. This method enables the identification and separation of endotoxin from medical materials with a detection limit of 0.03 ng mL-1 endotoxins in aqueous solution. Ophthalmic viscosurgical device materials including sodium hyaluronate (NaHA), non-water soluble perfluoro-n-octane (PFO) and silicone oil (SO) were spiked with different known concentrations of endotoxin and analyzed by DART MS, where the presence of endotoxin was successfully detected and featured small mass fragment ions were generated for NaHA, PFO and SO as well. Current findings showed the feasibility of measuring endotoxin contamination in medical device materials using DART-MS, which can lead to a one-step analysis of endotoxins in different matrices, avoiding any potential contamination during sample pre-treatment steps. Published by Elsevier B.V. JF - Analytica chimica acta AU - Li, Hongli AU - Hitchins, Victoria M AU - Wickramasekara, Samanthi AD - Division of Biology, Chemistry, and Materials Science, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, 20993, United States; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. ; Division of Biology, Chemistry, and Materials Science, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, 20993, United States. ; Division of Biology, Chemistry, and Materials Science, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, 20993, United States. Electronic address: Samanthi.Wickramasekara@fda.hhs.gov. Y1 - 2016/11/02/ PY - 2016 DA - 2016 Nov 02 SP - 98 EP - 105 VL - 943 KW - Silicone oil KW - Endotoxin KW - Sodium hyaluronate KW - Mass spectrometry KW - Direct analysis in real time KW - Perfluoro-n-octane UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835524679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+chimica+acta&rft.atitle=Rapid+detection+of+bacterial+endotoxins+in+ophthalmic+viscosurgical+device+materials+by+direct+analysis+in+real+time+mass+spectrometry.&rft.au=Li%2C+Hongli%3BHitchins%2C+Victoria+M%3BWickramasekara%2C+Samanthi&rft.aulast=Li&rft.aufirst=Hongli&rft.date=2016-11-02&rft.volume=943&rft.issue=&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Analytica+chimica+acta&rft.issn=1873-4324&rft_id=info:doi/10.1016%2Fj.aca.2016.09.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aca.2016.09.030 ER - TY - JOUR T1 - DYNAMIC RESPONSE OF CCD ARRAY SPECTRORADIOMETERS AN - 1868319859; PQ0004026973 AB - A number of factors affect the measurements by charge coupled (CCD) array spectroradiometers, including stray light, dynamic response and ambient temperature. The departure from linearity was assessed for four CCD array spectroradiometers and linearity correction calculated with standard uncertainties error estimates. A fixed irradiance source supplemented with neutral density filters was used to allow tests to cover a full range of operational conditions. The dependence of the dynamic response on well depth and integration time was investigated. One spectroradiometer exhibited an accumulated departure from linearity of -20 % near the top of the well; for others the departure from linearity was less pronounced. JF - Radiation Protection Dosimetry AU - Baczynska, Katarzyna Anna AU - Price, Luke L A AU - Khazova, Marina AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, UK, katarzyna.baczynska@PHE.gov.uk Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 291 EP - 296 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 171 IS - 3 SN - 0144-8420, 0144-8420 KW - Environment Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868319859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=DYNAMIC+RESPONSE+OF+CCD+ARRAY+SPECTRORADIOMETERS&rft.au=Baczynska%2C+Katarzyna+Anna%3BPrice%2C+Luke+L+A%3BKhazova%2C+Marina&rft.aulast=Baczynska&rft.aufirst=Katarzyna&rft.date=2016-11-01&rft.volume=171&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncv396 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1093/rpd/ncv396 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIM® VX IN WISTAR HAN [Crl:WI (Han)] RATS AND B6C3F1/N MICE (INHALATION STUDIES) AN - 1854174767 AB - TRIM VX is a metalworking fluid used as a lubricant and coolant liquid for cleaning tools and parts during cutting, drilling, milling, and grinding. Occupational exposures to metalworking fluids, including TRIM VX, occur primarily by dermal contact and inhalation. Inhalation exposure to other metalworking fluids has been reported to cause respiratory problems and to be associated with other health effects. We conducted studies of TRIM VX in rats and mice to determine if it caused cancer or other health effects. We exposed groups of 50 male and female rats and mice to atmospheres containing aerosols of 10, 30, or 100 mg of TRIM VX per cubic meter of air. Similar groups of animals exposed to clean air in the same type of inhalation chambers served as the control groups. Animals were exposed six hours per day, five days per week for two years. Tissues from more than 40 sites were examined for every animal. The respiratory tract was the primary site of toxicity in all groups of male and female rats and mice exposed to TRIM VX. A wide spectrum of lesions (i.e., hyperplasia, inflammation, metaplasia, fibrosis) of the lung, nose, larynx, and lymph nodes was seen. The lesions were significantly increased across exposed groups of rats and mice, and many were observed at the lowest concentration tested (10 mg/m^sup 3^). In addition to these lesions, there were low occurrences of lung tumors in male and female rats and increases in the incidences of lung tumors in male and female mice exposed to the highest concentration of TRIM VX. We conclude that exposure to aerosols of TRIM VX caused tumors of the lung in male and female mice and may have caused tumors of the lung in male and female rats. TRIM VX also caused a spectrum of lesions in the respiratory tract of male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 1 EP - 13,15,17-23,25-65J,67-71,73-93,95-141,143-155,157-186 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Tumors KW - Rodents KW - Animal behavior KW - Females UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1854174767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+TRIM%C2%AE+VX+IN+WISTAR+HAN+%5BCrl%3AWI+%28Han%29%5D+RATS+AND+B6C3F1%2FN+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-11-01&rft.volume=&rft.issue=591&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Name - National Institute for Occupational Safety & Health N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2016 N1 - Document feature - References; Tables; Graphs N1 - Last updated - 2016-12-30 ER - TY - RPRT T1 - Table of contents AN - 1854174728 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1854174728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-11-01&rft.volume=&rft.issue=591&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2016 N1 - Last updated - 2016-12-30 ER - TY - RPRT T1 - FOREWORD AN - 1854174573 AB - The National Toxicology Program (NTP) is an interagency program within the Public Health Service (PHS) of the Department of Health and Human Services (HHS) and is headquartered at the National Institute of Environmental Health Sciences of the National Institutes of Health (NIEHS/NIH). JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Public health KW - Health services KW - Laboratory animals KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1854174573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-11-01&rft.volume=&rft.issue=591&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Name - Food & Drug Administration--FDA; Department of Health & Human Services N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2016 N1 - Last updated - 2016-12-30 ER - TY - JOUR T1 - Adaptive Design Practice at the Center for Devices and Radiological Health (CDRH), January 2007 to May 2013 AN - 1846421960; PQ0003863090 AB - Adaptive designs have generated great interest in the clinical trial community as a result of their versatility and efficiency. Recently, the Center for Devices and Radiological Health (CDRH) at the US Food and Drug Administration (FDA) surveyed all adaptive design applications submitted between 2007 and May 2013 for regulatory review. In this paper, we discuss the overall results and findings that emerged from an in-depth examination of the submissions. We summarize the current status of adaptive designs used in medical device studies. We also identify some of the lessons learned and common pitfalls that we encountered in our review of the designs. JF - Therapeutic Innovation & Regulatory Science AU - Yang, Xiting AU - Thompson, Laura AU - Chu, Jianxiong AU - Liu, Sherry AU - Lu, Hong AU - Zhou, Jie AU - Gomatam, Shanti AU - Tang, Rong AU - Zhao, Yu AU - Ge, Yunjiang AU - Gray, Gerry W AD - 1 .Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA, xiting.yang@fda.hhs.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 710 EP - 717 PB - Sage Publications, Inc. VL - 50 IS - 6 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - adaptive design KW - medical device KW - survey KW - FDA KW - Reviews KW - Drug development KW - Clinical trials KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846421960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Trends+in+worker+hearing+loss+by+industry+sector%2C+1981-2010&rft.au=Masterson%2C+Elizabeth+A%3BDeddens%2C+James+A%3BThemann%2C+Christa+L%3BBertke%2C+Stephen%3BCalvert%2C+Geoffrey+M&rft.aulast=Masterson&rft.aufirst=Elizabeth&rft.date=2015-04-01&rft.volume=58&rft.issue=4&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22429 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 22 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Reviews; Drug development; Clinical trials DO - http://dx.doi.org/10.1177/2168479016656027 ER - TY - JOUR T1 - Expanded Access of Investigational Drugs: The Experience of the Center of Drug Evaluation and Research Over a 10-Year Period AN - 1846420079; PQ0003863104 AB - Background: The purpose of this study was to describe the experience of the Center of Drug Evaluation and Research (CDER) with expanded access of investigational drugs. Methods: Multiple searches of CDER's document tracking system were performed to identify the number, type, and indication for all expanded access requests over the 10-year time period of January 2005 through December 2014. An additional search was performed to identify all active commercial investigational drug development programs during that time period and whether or not the clinical program was placed on hold. The two searches were then cross-referenced to identify those commercial investigational drug development programs placed on clinical hold due to serious adverse events occurring within expanded access programs. Results: CDER receives over 1000 applications for expanded access each year. The majority are for single patients, roughly evenly split between emergency and nonemergency use. The vast majority, 99.7%, are allowed to proceed. The incidence of clinical holds for all commercial investigational drug development programs is 7.9%, as compared to only 0.2% related to adverse events observed in patients receiving drug treatments under expanded access. Conclusions: The expanded access program is viewed as a success from FDA's perspective based on the large number of applications processed and allowed to proceed each year. However, the actual number of patients and their health care providers that desire drug treatments available under expanded access is not known. It is exceedingly rare for a serious adverse event under expanded access to affect the development program for that drug. JF - Therapeutic Innovation & Regulatory Science AU - Jarow, Jonathan P AU - Lemery, Steven AU - Bugin, Kevin AU - Khozin, Sean AU - Moscicki, Richard AD - 1 .Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA, jonathan.jarow@fda.hhs.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 705 EP - 709 PB - Sage Publications, Inc. VL - 50 IS - 6 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - expanded access KW - compassionate use KW - US Food and Drug Administration KW - Drug development KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846420079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Unstable+Sitting+in+the+Workplace-Are+There+Physical+Activity+Benefits%3F&rft.au=Lowe%2C+Brian+D%3BSwanson%2C+Naomi+G%3BHudock%2C+Stephen+D%3BLotz%2C+W+Gregory&rft.aulast=Lowe&rft.aufirst=Brian&rft.date=2015-04-01&rft.volume=29&rft.issue=4&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/10.4278%2Fajhp.140331-CIT-127 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 10 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Drug development; Drugs DO - http://dx.doi.org/10.1177/2168479016656030 ER - TY - JOUR T1 - Stratification, Hypothesis Testing, and Clinical Trial Simulation in Pediatric Drug Development AN - 1846413613; PQ0003863103 AB - Background: Pediatric drug development is plagued by small sample sizes, unvalidated clinical endpoints, and limited studies. Objectives: The objective of this study was to determine whether age stratification within the pediatric population could be used to (1) assess response to a pharmacologic intervention and to (2) design future trials based upon published stratified disease data using clinical trial simulation (CTS). Methods: Data available from the literature for Kawasaki disease (KD) was used in the model. Age-stratified CTS for a theoretical new drug was conducted. Results: Population-specific differences due to age might affect trial success if not taken into account. CTS predicted inflammatory indices, and inclusion cutoff significantly altered the trial outcome. Finally, altered pharmacokinetics/pharmacodynamics in varying age groups of KD patients may alter drug exposure and response. Conclusions: If assumptions regarding a pediatric disease process, such as KD, do not include age stratification with inclusion or response, then the wrong decision could result with regard to age-appropriateness or approval of a drug. JF - Therapeutic Innovation & Regulatory Science AU - McMahon, Ann W AU - Watt, Kevin AU - Wang, Jian AU - Green, Dionna AU - Tiwari, Ram AU - Burckart, Gilbert J AD - 1 .Office of Pediatric Therapeutics, Office of the Commissioner, Food and Drug Administration, Silver Spring, MD, USA, ann.mcmahon@fda.hhs.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 817 EP - 822 PB - Sage Publications, Inc. VL - 50 IS - 6 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - Kawasaki disease KW - age groups KW - modeling KW - pharmacokinetics pharmacodynamics KW - Age KW - Data processing KW - Pediatrics KW - Drug development KW - Clinical trials KW - Drugs KW - Mucocutaneous lymph node syndrome KW - Pharmacokinetics KW - Pharmacodynamics KW - Models KW - Inflammation KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846413613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Healthcare+Materials&rft.atitle=Laser+3D+Printing+with+Sub-Microscale+Resolution+of+Porous+Elastomeric+Scaffolds+for+Supporting+Human+Bone+Stem+Cells&rft.au=Petrochenko%2C+Peter+E%3BTorgersen%2C+Jan%3BGruber%2C+Peter%3BHicks%2C+Lucas+A%3BZheng%2C+Jiwen%3BKumar%2C+Girish%3BNarayan%2C+Roger+J%3BGoering%2C+Peter+L%3BLiska%2C+Robert%3BStampfl%2C+Juergen%3BOvsianikov%2C+Aleksandr&rft.aulast=Petrochenko&rft.aufirst=Peter&rft.date=2015-04-01&rft.volume=4&rft.issue=5&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Advanced+Healthcare+Materials&rft.issn=21922640&rft_id=info:doi/10.1002%2Fadhm.201400442 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 16 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Pediatrics; Drug development; Drugs; Clinical trials; Pharmacodynamics; Pharmacokinetics; Mucocutaneous lymph node syndrome; Inflammation; Models DO - http://dx.doi.org/10.1177/2168479016651661 ER - TY - JOUR T1 - An FDA Analysis of Formal Dispute Resolution in the Center for Drug Evaluation and Research: 2003 Through 2014 AN - 1846409763; PQ0003863096 AB - Scientific and/or medical disputes will inevitably arise with regard to the US Food and Drug Administration's (FDA's) decision making related to drug development, new drug review, generic drug review, and postmarketing oversight. As these disputes can involve complex judgments and issues that are scientifically and commercially important, it is critical that FDA have procedures for effective and efficient resolution. FDA regulations allow a sponsor to obtain a review of an FDA decision by submitting a request for formal dispute resolution (an appeal). FDA's Center for Drug Evaluation and Research (CDER) received 137 appeal issues for fiscal years 2003 through 2014. However, sponsors can appeal the same issue multiple times, and each is considered a unique appeal; CDER received and analyzed 173 of these unique appeals. Of these 173 unique appeals, CDER accepted 140 (81%) for review and refused to accept for review 25 (14%). Eight (5%) were withdrawn by the sponsor prior to CDER making a decision whether to accept the appeal for review. Of the 140 unique appeals accepted and reviewed, CDER granted 23 (16%) appeals and denied 117 (84%). The analysis also examines an array of aspects of the process, such as (1) reasons why CDER rejected appeals, (2) reasons why sponsors submitted appeals, (3) the types of appeals that sponsors submitted, (4) the characteristics of the sponsors that submitted appeals (eg, size, past regulatory experience, legal representation), and (5) CDER's performance in meeting user fee goals associated with dispute resolution. JF - Therapeutic Innovation & Regulatory Science AU - Sharma, Khushboo AU - Harrington, Afi AU - Worrell, Sallamar AU - Bertha, Amy AD - 1 .Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA, Khushboo.Sharma@fda.hhs.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 697 EP - 704 PB - Sage Publications, Inc. VL - 50 IS - 6 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - appeal KW - 30-day goal KW - formal dispute resolution KW - appeal issues KW - FDA deciding official KW - Decision making KW - Reviews KW - Drug development KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846409763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+Innovation+%26+Regulatory+Science&rft.atitle=An+FDA+Analysis+of+Formal+Dispute+Resolution+in+the+Center+for+Drug+Evaluation+and+Research%3A+2003+Through+2014&rft.au=Sharma%2C+Khushboo%3BHarrington%2C+Afi%3BWorrell%2C+Sallamar%3BBertha%2C+Amy&rft.aulast=Sharma&rft.aufirst=Khushboo&rft.date=2016-11-01&rft.volume=50&rft.issue=6&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Therapeutic+Innovation+%26+Regulatory+Science&rft.issn=21684790&rft_id=info:doi/10.1177%2F2168479016651297 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 9 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Decision making; Reviews; Drug development DO - http://dx.doi.org/10.1177/2168479016651297 ER - TY - JOUR T1 - Flavoured non-cigarette tobacco product use among US adults: 2013-2014 AN - 1846396774; PQ0003890692 AB - IntroductionLimited data exist on flavoured non-cigarette tobacco product (NCTP) use among US adults.MethodsData from the 2013 to 2014 National Adult Tobacco Survey (N=75233), a landline and cellular telephone survey of US adults aged greater than or equal to 18, were assessed to estimate past 30-day NCTP use, flavoured NCTP use and flavour types using bivariate analyses.ResultsDuring 2013-2014, 14.4% of US adults were past 30-day NCTP users. Nationally, an estimated 10.2 million e-cigarette users (68.2%), 6.1 million hookah users (82.3%), 4.1 million cigar smokers (36.2%) and 4.0 million smokeless tobacco users (50.6%) used flavoured products in the past 30days. The most prevalent flavours reported were menthol/mint (76.9%) for smokeless tobacco; fruit (74.0%) for hookah; fruit (52.4%), candy/chocolate/other sweet flavours (22.0%) and alcohol (14.5%) for cigars/cigarillos/filtered little cigars; fruit (44.9%), menthol/mint (43.9%) and candy/chocolate/other sweet flavours (25.7%) for e-cigarettes and fruit (56.6%), candy/chocolate/other sweet flavours (26.5%) and menthol/mint (24.8%) for pipes. Except for hookah and pipes, past 30-day flavoured product use was highest among 18-24-year olds. By cigarette smoking, never smoking e-cigarette users (84.8%) were more likely to report flavoured e-cigarette use, followed by recent former smokers (78.1%), long-term former smokers (70.4%) and current smokers (63.2%).ConclusionsFlavoured NCTP use is prominent among US adult tobacco users, particularly among e-cigarette, hookah and cigar users. Flavoured product use, especially fruit and sweet-flavoured products, was higher among younger adults. It is important for tobacco prevention and control strategies to address all forms of tobacco use, including flavoured tobacco products. JF - Tobacco Control AU - Bonhomme, Michele G AU - Holder-Hayes, Enver AU - Ambrose, Bridget K AU - Tworek, Cindy AU - Feirman, Shari P AU - King, Brian A AU - Apelberg, Benjamin J AD - Food and Drug Administration, Center for Tobacco Products, Office of Science, , Silver Spring, Maryland, USA Y1 - 2016/11// PY - 2016 DA - November 2016 SP - ii4 EP - ii13 PB - BMJ Publishing Group Ltd. VL - 25 IS - Suppl 2 SN - 0964-4563, 0964-4563 KW - Toxicology Abstracts KW - Non-cigarette tobacco products KW - Surveillance and monitoring KW - Priority/special populations KW - Disparities KW - Electronic nicotine delivery devices KW - Fruits KW - Flavor KW - Sweet taste KW - Data processing KW - Cigarette smoking KW - Tobacco KW - alcohols KW - Chocolate KW - Cellular telephones KW - Menthol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846396774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+Control&rft.atitle=Flavoured+non-cigarette+tobacco+product+use+among+US+adults%3A+2013-2014&rft.au=Bonhomme%2C+Michele+G%3BHolder-Hayes%2C+Enver%3BAmbrose%2C+Bridget+K%3BTworek%2C+Cindy%3BFeirman%2C+Shari+P%3BKing%2C+Brian+A%3BApelberg%2C+Benjamin+J&rft.aulast=Bonhomme&rft.aufirst=Michele&rft.date=2016-11-01&rft.volume=25&rft.issue=Suppl+2&rft.spage=ii4&rft.isbn=&rft.btitle=&rft.title=Tobacco+Control&rft.issn=09644563&rft_id=info:doi/10.1136%2Ftobaccocontrol-2016-053373 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Fruits; Sweet taste; Flavor; Data processing; Cigarette smoking; alcohols; Tobacco; Chocolate; Cellular telephones; Menthol DO - http://dx.doi.org/10.1136/tobaccocontrol-2016-053373 ER - TY - JOUR T1 - Development and validation of an assessment tool for a national young worker curriculum AN - 1837326346; PQ0003760106 AB - Background An online, multiple-choice assessment was developed and validated for YouthWork-Talking Safety a NIOSH curriculum that equips middle and high school students with foundational workplace safety and health knowledge and skills. Methods Classical Test Theory was used for the test development and validation; the Jaeger method was used for cut score determination. A total of 118 multiple-choice items were developed to measure the acquisition of knowledge and skills taught through the NIOSH curriculum. Pilot testing was conducted with 192 8-12th grade students and a cut score was determined. Results The mean score for all test-takers on the Talking Safety assessment was 80.9%; total test reliability measured using an Alpha/KR20 statistic was 0.93. A minimum passing (cut) score of 74% was established. Conclusions The assessment provides an objective measure of students' acquisition of the foundational workplace safety and health competencies taught through the Talking Safety curriculum. Am. J. Ind. Med. 59:969-978, 2016. JF - American Journal of Industrial Medicine AU - Guerin, Rebecca J AU - Okun, Andrea H AU - Kelley, Patricia AD - National Institute for Occupational Safety and Health, U.S. Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 969 EP - 978 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 11 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Safety KW - Occupational safety KW - Adolescents KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837326346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Development+and+validation+of+an+assessment+tool+for+a+national+young+worker+curriculum&rft.au=Guerin%2C+Rebecca+J%3BOkun%2C+Andrea+H%3BKelley%2C+Patricia&rft.aulast=Guerin&rft.aufirst=Rebecca&rft.date=2016-11-01&rft.volume=59&rft.issue=11&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22610 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-11-23 N1 - SubjectsTermNotLitGenreText - Occupational safety; Safety; Adolescents DO - http://dx.doi.org/10.1002/ajim.22610 ER - TY - JOUR T1 - Outcomes of on-site antiretroviral therapy provision in a South African correctional facility AN - 1837311451; PQ0003812311 AB - We evaluated a novel on-site antiretroviral therapy (ART) programme in a South African correctional facility using routinely collected programme data, from a retrospective cohort of adult inmates starting ART between 03/2007 and 03/2009 followed-up to 09/2009. We report (1) mortality (using survival analysis); (2) retention in the programme (to 09/2009); and (3) virological suppression at six and 12 months (6 months (95% confidence interval 1.1-7.5)/100 person-years; p <0.001. At 09/2009, 35.6% (144/404) remained in the correctional facility, with 94.4% (136/144) retained in the programme; 38.4% (155/404) were released; and 20.0% (81/404) transferred to another facility. ART-naive patients in care six and 12 months after ART initiation, 94.7% (124/131) and 92.5% (74/80) were virologically suppressed, respectively. High early mortality warrants the early identification and management of HIV-positive inmates. The high mobility of inmates necessitates systems for facilitating continuity of care. Good virological responses and retention supports decentralising HIV care to correctional facilities. JF - International Journal of STD & AIDS AU - Telisinghe, Lilanganee AU - Hippner, Piotr AU - Churchyard, Gavin J AU - Gresak, Gillian AU - Grant, Alison D AU - Charalambous, Salome AU - Fielding, Katherine L AD - 1 .The Aurum Institute, Johannesburg, South Africa, lily.telisinghe@phe.gov.uk Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1153 EP - 1161 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 27 IS - 13 SN - 0956-4624, 0956-4624 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - HIV KW - AIDS KW - treatment KW - prisoners KW - correctional facilities KW - inmates KW - antiretroviral therapy KW - Prisons KW - Mortality KW - Acquired immune deficiency syndrome KW - Age KW - Data processing KW - Mobility KW - Retroviridae KW - Survival KW - Antiretroviral agents KW - CD4 antigen KW - Lentivirus KW - Sexually transmitted diseases KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837311451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=Outcomes+of+on-site+antiretroviral+therapy+provision+in+a+South+African+correctional+facility&rft.au=Telisinghe%2C+Lilanganee%3BHippner%2C+Piotr%3BChurchyard%2C+Gavin+J%3BGresak%2C+Gillian%3BGrant%2C+Alison+D%3BCharalambous%2C+Salome%3BFielding%2C+Katherine+L&rft.aulast=Telisinghe&rft.aufirst=Lilanganee&rft.date=2016-11-01&rft.volume=27&rft.issue=13&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462415584467 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 65 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mortality; Age; CD4 antigen; Data processing; Mobility; antiretroviral therapy; Prisons; Acquired immune deficiency syndrome; Survival; Antiretroviral agents; Sexually transmitted diseases; Lentivirus; Retroviridae DO - http://dx.doi.org/10.1177/0956462415584467 ER - TY - JOUR T1 - Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development AN - 1837306117; PQ0003734495 AB - During drug development, matching adult systemic exposures of drugs is a common approach for dose selection in pediatric patients when efficacy is partially or fully extrapolated. This is a systematic review of approaches used for matching adult systemic exposures as the basis for dose selection in pediatric trials submitted to the US Food and Drug Administration (FDA) between 1998 and 2012. The trial design of pediatric pharmacokinetic (PK) studies and the pediatric and adult systemic exposure data were obtained from FDA publicly available databases containing reviews of pediatric trials. Exposure-matching approaches that were used as the basis for pediatric dose selection were reviewed. The PK data from the adult and pediatric populations were used to quantify exposure agreement between the 2 patient populations. The main measures were the pediatric PK studies' trial design elements and drug systemic exposures (adult and pediatric). There were 31 products (86 trials) with full or partial extrapolation of efficacy with an available PK assessment. Pediatric exposures had a range of mean C sub(max) and AUC ratios (pediatric/adult) of 0.63 to 4.19 and 0.36 to 3.60, respectively. Seven of the 86 trials (8.1%) had a predefined acceptance boundary used to match adult exposures. The key PK parameter was consistently predefined for antiviral and anti-infective products. Approaches to match exposure in children and adults varied across products. A consistent approach for systemic exposure matching and evaluating pediatric PK studies is needed to guide future pediatric trials. JF - Journal of Clinical Pharmacology AU - Mulugeta, Yeruk AU - Barrett, Jeffrey S AU - Nelson, Robert AU - Eshete, Abel Tilahun AU - Mushtaq, Alvina AU - Yao, Lynne AU - Glasgow, Nicole AU - Mulberg, Andrew E AU - Gonzalez, Daniel AU - Green, Dionna AU - Florian, Jeffry AU - Krudys, Kevin AU - Seo, Shirley AU - Kim, Insook AU - Chilukuri, Dakshina AU - Burckart, Gilbert J AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1326 EP - 1334 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 56 IS - 11 SN - 0091-2700, 0091-2700 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Data processing KW - Antiviral agents KW - Pediatrics KW - Boundaries KW - Drug development KW - Children KW - Clinical trials KW - Pharmacokinetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837306117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Exposure+Matching+for+Extrapolation+of+Efficacy+in+Pediatric+Drug+Development&rft.au=Mulugeta%2C+Yeruk%3BBarrett%2C+Jeffrey+S%3BNelson%2C+Robert%3BEshete%2C+Abel+Tilahun%3BMushtaq%2C+Alvina%3BYao%2C+Lynne%3BGlasgow%2C+Nicole%3BMulberg%2C+Andrew+E%3BGonzalez%2C+Daniel%3BGreen%2C+Dionna%3BFlorian%2C+Jeffry%3BKrudys%2C+Kevin%3BSeo%2C+Shirley%3BKim%2C+Insook%3BChilukuri%2C+Dakshina%3BBurckart%2C+Gilbert+J&rft.aulast=Mulugeta&rft.aufirst=Yeruk&rft.date=2016-11-01&rft.volume=56&rft.issue=11&rft.spage=1326&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1002%2Fjcph.744 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Antiviral agents; Pediatrics; Boundaries; Drug development; Children; Clinical trials; Pharmacokinetics DO - http://dx.doi.org/10.1002/jcph.744 ER - TY - JOUR T1 - Shiftwork and decline in endothelial function among police officers AN - 1837306076; PQ0003760107 AB - Background Our objective was to assess the influence of shiftwork on change in endothelial function. Methods This longitudinal study was conducted in 188 police officers (78.2% men). Shiftwork status (day, afternoon, night) was assessed objectively using daily Buffalo, NY payroll work history records. Brachial artery flow-mediated dilation (FMD) was assessed using ultrasound. Mean change in FMD% between 2004-2009 and 2010-2015 was compared across shiftwork using analysis of variance/covariance. Results Overall, mean FMD% decreased from 5.74 plus or minus 2.83 to 3.88 plus or minus 2.11 over an average of 7 years among all officers; P<0.0001. Effect modification by gender was significant. Among men (but not women), those who worked day shifts had a smaller mean ( plus or minus SE) decrease in FMD% (-0.89 plus or minus 0.35) compared with those who worked the afternoon (-2.69 plus or minus 0.39; P=0.001) or night shifts (-2.31 plus or minus 0.45; P=0.020) after risk factor adjustment. Conclusions Larger declines in endothelial function were observed among men who worked afternoon or night shifts. Further investigation is warranted. Am. J. Ind. Med. 59:1001-1008, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA JF - American Journal of Industrial Medicine AU - Charles, Luenda E AU - Zhao, Songzhu AU - Fekedulegn, Desta AU - Violanti, John M AU - Andrew, Michael E AU - Burchfiel, Cecil M AD - Health Effects Laboratory Division, Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1001 EP - 1008 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 11 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Longitudinal studies KW - Shift work KW - Historical account KW - USA KW - Risk factors KW - Gender KW - Police KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837306076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Shiftwork+and+decline+in+endothelial+function+among+police+officers&rft.au=Charles%2C+Luenda+E%3BZhao%2C+Songzhu%3BFekedulegn%2C+Desta%3BViolanti%2C+John+M%3BAndrew%2C+Michael+E%3BBurchfiel%2C+Cecil+M&rft.aulast=Charles&rft.aufirst=Luenda&rft.date=2016-11-01&rft.volume=59&rft.issue=11&rft.spage=1001&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22611 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-11-23 N1 - SubjectsTermNotLitGenreText - Longitudinal studies; Historical account; Shift work; Risk factors; Gender; Police; USA DO - http://dx.doi.org/10.1002/ajim.22611 ER - TY - JOUR T1 - Mortality of lead smelter workers: A follow-up study with exposure assessment AN - 1837301860; PQ0003760110 AB - Background Lead exposure has been linked to impaired renal function and kidney failure. High lead exposures have been associated with increased mortality from certain cancers, hypertension, cardiovascular disease, and amyotrophic lateral sclerosis (ALS). Methods We extended vital status follow-up on a cohort of 1,990 lead smelter workers by 25 years and computed standardized mortality ratios and rate ratios (RR) stratified by cumulative lead exposure. Results The update added 13,823 person-years at risk and 721 deaths. Increased risk of mortality was observed for the a priori outcomes of lung cancer, cardiovascular disease (including cerebrovascular disease), chronic kidney disease, and ALS. However, of these outcomes, only cardiovascular, cerebrovascular, and chronic kidney diseases were associated with a positive exposure-response in RR analyses. Conclusions This study reaffirms the association of lead exposure with cardiovascular and kidney diseases; however, increased mortality observed for certain cancers is not likely to be due to lead exposure. Am. J. Ind. Med. 59:979-986, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Bertke, Stephen J AU - Lehman, Everett J AU - Wurzelbacher, Steven J AU - Hein, Misty J AD - Division of Surveillance, Hazard Evaluations, and Field Studies, Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 979 EP - 986 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 11 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Lead KW - Renal function KW - Dose-response effects KW - Occupational exposure KW - Lung cancer KW - Mortality KW - Cerebrovascular diseases KW - Kidney diseases KW - Renal failure KW - Smelters KW - Cancer KW - Health risks KW - USA KW - Amyotrophic lateral sclerosis KW - Standards KW - Mining KW - Cardiovascular diseases KW - Hypertension KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837301860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+of+lead+smelter+workers%3A+A+follow-up+study+with+exposure+assessment&rft.au=Bertke%2C+Stephen+J%3BLehman%2C+Everett+J%3BWurzelbacher%2C+Steven+J%3BHein%2C+Misty+J&rft.aulast=Bertke&rft.aufirst=Stephen&rft.date=2016-11-01&rft.volume=59&rft.issue=11&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mortality; Cerebrovascular diseases; Kidney diseases; Renal failure; Smelters; Lead; Amyotrophic lateral sclerosis; Renal function; Dose-response effects; Cardiovascular diseases; Occupational exposure; Hypertension; Lung cancer; Risk assessment; Cancer; Health risks; Standards; Mining; USA DO - http://dx.doi.org/10.1002/ajim.22618 ER - TY - JOUR T1 - Secondhand smoke in the operating room? Precautionary practices lacking for surgical smoke AN - 1837301253; PQ0003760109 AB - Background Consensus organizations, government bodies, and healthcare organization guidelines recommend that surgical smoke be evacuated at the source by local exhaust ventilation (LEV) (i.e., smoke evacuators or wall suctions with inline filters). Methods Data are from NIOSH's Health and Safety Practices Survey of Healthcare Workers module on precautionary practices for surgical smoke. Results Four thousand five hundred thirty-three survey respondents reported exposure to surgical smoke: 4,500 during electrosurgery; 1,392 during laser surgery procedures. Respondents were mainly nurses (56%) and anesthesiologists (21%). Only 14% of those exposed during electrosurgery reported LEV was always used during these procedures, while 47% reported use during laser surgery. Those reporting LEV was always used were also more likely to report training and employer standard procedures addressing the hazards of surgical smoke. Few respondents reported use of respiratory protection. Conclusions Study findings can be used to raise awareness of the marginal use of exposure controls and impediments for their use. Am. J. Ind. Med. 59:1020-1031, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA JF - American Journal of Industrial Medicine AU - Steege, Andrea L AU - Boiano, James M AU - Sweeney, Marie H AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1020 EP - 1031 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 11 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Ventilation KW - Training KW - Guidelines KW - Safety KW - Medical personnel KW - Smoke KW - Filters KW - USA KW - Passive smoking KW - Health care KW - Surgery KW - Nursing KW - Lasers KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837301253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Secondhand+smoke+in+the+operating+room%3F+Precautionary+practices+lacking+for+surgical+smoke&rft.au=Steege%2C+Andrea+L%3BBoiano%2C+James+M%3BSweeney%2C+Marie+H&rft.aulast=Steege&rft.aufirst=Andrea&rft.date=2016-11-01&rft.volume=59&rft.issue=11&rft.spage=1020&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22614 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-11-23 N1 - SubjectsTermNotLitGenreText - Filters; Smoke; Passive smoking; Ventilation; Health care; Training; Nursing; Surgery; Safety; Guidelines; Lasers; Medical personnel; USA DO - http://dx.doi.org/10.1002/ajim.22614 ER - TY - JOUR T1 - Absolute Measurement of Cardiac Injury-Induced microRNAs in Biofluids across Multiple Test Sites. AN - 1835684828; 27605421 AB - Extracellular microRNAs (miRNAs) represent a promising new source of toxicity biomarkers that are sensitive indicators of site of tissue injury. In order to establish reliable approaches for use in biomarker validation studies, the HESI technical committee on genomics initiated a multi-site study to assess sources of variance associated with quantitating levels of cardiac injury induced miRNAs in biofluids using RT-qPCR. Samples were generated at a central site using a model of acute cardiac injury induced in male Wistar rats by 0.5 mg/kg isoproterenol. Biofluid samples were sent to 11 sites for measurement of 3 cardiac enriched miRNAs (miR-1-3p, miR-208a-3p, and miR-499-5p) and 1 miRNA abundant in blood (miR-16-5p) or urine (miR-192-5p) by absolute quantification using calibration curves of synthetic miRNAs. The samples included serum and plasma prepared from blood collected at 4 h, urine collected from 6 to 24 h, and plasma prepared from blood collected at 24 h post subcutaneous injection. A 3 parameter logistic model was utilized to fit the calibration curve data and estimate levels of miRNAs in biofluid samples by inverse prediction. Most sites observed increased circulating levels of miR-1-3p and miR-208a-3p at 4 and 24 h after isoproterenol treatment, with no difference seen between serum and plasma. The biological differences in miRNA levels and sample type dominated as sources of variance, along with outlying performance by a few sites. The standard protocol established in this study was successfully implemented across multiple sites and provides a benchmark method for further improvements in quantitative assays for circulating miRNAs. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Thompson, Karol L AU - Boitier, Eric AU - Chen, Tao AU - Couttet, Philippe AU - Ellinger-Ziegelbauer, Heidrun AU - Goetschy, Manuela AU - Guillemain, Gregory AU - Kanki, Masayuki AU - Kelsall, Janet AU - Mariet, Claire AU - de La Moureyre-Spire, Catherine AU - Mouritzen, Peter AU - Nassirpour, Rounak AU - O'Lone, Raegan AU - Pine, P Scott AU - Rosenzweig, Barry A AU - Sharapova, Tatiana AU - Smith, Aaron AU - Uchiyama, Hidefumi AU - Yan, Jian AU - Yuen, Peter S AU - Wolfinger, Russ AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993. ; Sanofi R&D, Disposition Safety and Animal Research, Vitry-Sur-Seine, France. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arizona 72079. ; Novartis Pharma AG, Basel, CH 4057, Switzerland. ; Toxicology, Bayer Pharma, Wuppertal, AG 42096, Germany. ; Astellas Pharma Inc, Osaka 532-8514, Japan. ; AstraZeneca Ltd, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. ; Institut De Recherches Servier, 78290 Croissy Sur Seine, France. ; Exiqon, Vedbaek DK-2950, Denmark. ; Pfizer, Andover, Massachusetts 01810. ; ILSI Health and Environmental Sciences Institute, Washington, DC 20005 Rolone@hesiglobal.org. ; National Institute of Standards and Technology, Stanford, California 94305. ; AbbVie, Abbott Park, Illinois 60064. ; Eli Lilly, Indianapolis, Indiana 46285. ; Takeda Pharmaceutical Co Ltd, Fujisawa, Kanagawa 251-8555, Japan. ; NIH/NIDDK, Bethesda, Maryland 20892. ; SAS Institute Inc, Cary, North Carolina 27513. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 115 EP - 125 VL - 154 IS - 1 KW - biomarker KW - variance KW - microRNA KW - interlaboratory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835684828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Absolute+Measurement+of+Cardiac+Injury-Induced+microRNAs+in+Biofluids+across+Multiple+Test+Sites.&rft.au=Thompson%2C+Karol+L%3BBoitier%2C+Eric%3BChen%2C+Tao%3BCouttet%2C+Philippe%3BEllinger-Ziegelbauer%2C+Heidrun%3BGoetschy%2C+Manuela%3BGuillemain%2C+Gregory%3BKanki%2C+Masayuki%3BKelsall%2C+Janet%3BMariet%2C+Claire%3Bde+La+Moureyre-Spire%2C+Catherine%3BMouritzen%2C+Peter%3BNassirpour%2C+Rounak%3BO%27Lone%2C+Raegan%3BPine%2C+P+Scott%3BRosenzweig%2C+Barry+A%3BSharapova%2C+Tatiana%3BSmith%2C+Aaron%3BUchiyama%2C+Hidefumi%3BYan%2C+Jian%3BYuen%2C+Peter+S%3BWolfinger%2C+Russ&rft.aulast=Thompson&rft.aufirst=Karol&rft.date=2016-11-01&rft.volume=154&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - County-Level Vulnerability Assessment for Rapid Dissemination of HIV or HCV Infections Among Persons Who Inject Drugs, United States. AN - 1835506163; 27763996 AB - A recent HIV outbreak in a rural network of persons who inject drugs (PWID) underscored the intersection of the expanding epidemics of opioid abuse, unsterile injection drug use (IDU), and associated increases in hepatitis C virus (HCV) infections. We sought to identify US communities potentially vulnerable to rapid spread of HIV, if introduced, and new or continuing high rates of HCV infections among PWID. We conducted a multistep analysis to identify indicator variables highly associated with IDU. We then used these indicator values to calculate vulnerability scores for each county to identify which were most vulnerable. We used confirmed cases of acute HCV infection reported to the National Notifiable Disease Surveillance System, 2012-2013, as a proxy outcome for IDU, and 15 county-level indicators available nationally in Poisson regression models to identify indicators associated with higher county acute HCV infection rates. Using these indicators, we calculated composite index scores to rank each county's vulnerability. A parsimonious set of 6 indicators were associated with acute HCV infection rates (proxy for IDU): drug-overdose deaths, prescription opioid sales, per capita income, white, non-Hispanic race/ethnicity, unemployment, and buprenorphine prescribing potential by waiver. Based on these indicators, we identified 220 counties in 26 states within the 95th percentile of most vulnerable. Our analysis highlights US counties potentially vulnerable to HIV and HCV infections among PWID in the context of the national opioid epidemic. State and local health departments will need to further explore vulnerability and target interventions to prevent transmission. JF - Journal of acquired immune deficiency syndromes (1999) AU - Van Handel, Michelle M AU - Rose, Charles E AU - Hallisey, Elaine J AU - Kolling, Jessica L AU - Zibbell, Jon E AU - Lewis, Brian AU - Bohm, Michele K AU - Jones, Christopher M AU - Flanagan, Barry E AU - Siddiqi, Azfar-E-Alam AU - Iqbal, Kashif AU - Dent, Andrew L AU - Mermin, Jonathan H AU - McCray, Eugene AU - Ward, John W AU - Brooks, John T AD - *Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA;†Geospatial Research, Analysis and Services Program, Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA;‡DRT Strategies With the Geospatial Research, Analysis and Services Program, Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA;§Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA;‖HP Enterprise Services With the Geospatial Research, Analysis and Services Program, Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA;¶Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA;#Division of Science Policy, Office of the Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, Washington, DC; and**National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA. Y1 - 2016/11/01/ PY - 2016 DA - 2016 Nov 01 SP - 323 EP - 331 VL - 73 IS - 3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835506163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=County-Level+Vulnerability+Assessment+for+Rapid+Dissemination+of+HIV+or+HCV+Infections+Among+Persons+Who+Inject+Drugs%2C+United+States.&rft.au=Van+Handel%2C+Michelle+M%3BRose%2C+Charles+E%3BHallisey%2C+Elaine+J%3BKolling%2C+Jessica+L%3BZibbell%2C+Jon+E%3BLewis%2C+Brian%3BBohm%2C+Michele+K%3BJones%2C+Christopher+M%3BFlanagan%2C+Barry+E%3BSiddiqi%2C+Azfar-E-Alam%3BIqbal%2C+Kashif%3BDent%2C+Andrew+L%3BMermin%2C+Jonathan+H%3BMcCray%2C+Eugene%3BWard%2C+John+W%3BBrooks%2C+John+T&rft.aulast=Van+Handel&rft.aufirst=Michelle&rft.date=2016-11-01&rft.volume=73&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=1944-7884&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - An FDA oncology analysis of immune activating products and first-in-human dose selection. AN - 1835434366; 27743776 AB - As sub-therapeutic doses are not medically justifiable in patients with cancer, we retrospectively analyzed data on immune activating products, to assess approaches used in first-in-human (FIH) dose selection, the utility of animal toxicology studies in dose selection, and the length of time to complete FIH trials. The information collected included pharmacology and toxicology data, FIH dose and rationale, and dose-finding trial design. We used the principles of the Hill equation to estimate the FIH doses for antibodies and compared them to the doses administered to patients with acceptable toxicities. For approximately half the antibodies (44%) examined, the FIH doses were at least a hundred-fold lower than the doses safely administered to patients, indicating optimization of FIH dose selection and/or optimization of dose-finding trial design is needed to minimize patient exposure to sub-therapeutic doses. However, selection of the FIH dose for antibodies based on animal toxicology studies using 1/6th the HNSTD or 1/10th the NOAEL resulted in human doses that were unsafe for several antibodies examined. We also concluded that antibodies with Fc-modifications for increased effector function may be less tolerated, resulting in toxicities at lower doses than those without such modifications. There was insufficient information to evaluate CD3 bispecific products. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Saber, Haleh AU - Gudi, Ramadevi AU - Manning, Michael AU - Wearne, Emily AU - Leighton, John K AD - US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Hematology and Oncology Products, 10903 New Hampshire Ave, Silver Spring, MD 20903, United States. Electronic address: haleh.saber@fda.hhs.gov. ; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Hematology and Oncology Products, 10903 New Hampshire Ave, Silver Spring, MD 20903, United States. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 448 EP - 456 VL - 81 KW - MABEL KW - Immune oncology KW - First-in-human dose UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835434366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=An+FDA+oncology+analysis+of+immune+activating+products+and+first-in-human+dose+selection.&rft.au=Saber%2C+Haleh%3BGudi%2C+Ramadevi%3BManning%2C+Michael%3BWearne%2C+Emily%3BLeighton%2C+John+K&rft.aulast=Saber&rft.aufirst=Haleh&rft.date=2016-11-01&rft.volume=81&rft.issue=&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.10.002 ER - TY - JOUR T1 - Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice. AN - 1835384955; 27644598 AB - Sex is a risk factor for development of cardiotoxicity, induced by the anti-cancer drug, doxorubicin (DOX), in humans. To explore potential mechanisms underlying differential susceptibility to DOX between sexes, 8-week old male and female B6C3F1 mice were dosed with 3mg/kg body weight DOX or an equivalent volume of saline via tail vein once a week for 6, 7, 8, and 9 consecutive weeks, resulting in 18, 21, 24, and 27mg/kg cumulative DOX doses, respectively. At necropsy, one week after each consecutive final dose, the extent of myocardial injury was greater in male mice compared to females as indicated by higher plasma concentrations of cardiac troponin T at all cumulative DOX doses with statistically significant differences between sexes at the 21 and 24mg/kg cumulative doses. A greater susceptibility to DOX in male mice was further confirmed by the presence of cytoplasmic vacuolization in cardiomyocytes, with left atrium being more vulnerable to DOX cardiotoxicity. The number of TUNEL-positive cardiomyocytes was mostly higher in DOX-treated male mice compared to female counterparts, showing a statistically significant sex-related difference only in left atrium at 21mg/kg cumulative dose. DOX-treated male mice also had an increased number of γ-H2A.X-positive (measure of DNA double-strand breaks) cardiomyocytes compared to female counterparts with a significant sex effect in the ventricle at 27mg/kg cumulative dose and right atrium at 21 and 27mg/kg cumulative doses. This newly established mouse model provides a means to identify biomarkers and access potential mechanisms underlying sex-related differences in DOX-induced cardiotoxicity. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Jenkins, G Ronald AU - Lee, Taewon AU - Moland, Carrie L AU - Vijay, Vikrant AU - Herman, Eugene H AU - Lewis, Sherry M AU - Davis, Kelly J AU - Muskhelishvili, Levan AU - Kerr, Susan AU - Fuscoe, James C AU - Desai, Varsha G AD - Personalized Medicine Branch, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; Department of Mathematics, Korea University, Sejong, Republic of Korea. ; Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, The National Cancer Institute, Rockville, MD 20850-9734, United States. ; Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Arkansas Heart Hospital, Little Rock, AR 72211, United States. ; Personalized Medicine Branch, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: varsha.desai@fda.hhs.gov. Y1 - 2016/11/01/ PY - 2016 DA - 2016 Nov 01 SP - 159 EP - 174 VL - 310 KW - DNA damage KW - Apoptosis KW - Mouse model KW - Sex-based differences KW - Cardiotoxicity KW - Doxorubicin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835384955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Sex-related+differential+susceptibility+to+doxorubicin-induced+cardiotoxicity+in+B6C3F1+mice.&rft.au=Jenkins%2C+G+Ronald%3BLee%2C+Taewon%3BMoland%2C+Carrie+L%3BVijay%2C+Vikrant%3BHerman%2C+Eugene+H%3BLewis%2C+Sherry+M%3BDavis%2C+Kelly+J%3BMuskhelishvili%2C+Levan%3BKerr%2C+Susan%3BFuscoe%2C+James+C%3BDesai%2C+Varsha+G&rft.aulast=Jenkins&rft.aufirst=G&rft.date=2016-11-01&rft.volume=310&rft.issue=&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.09.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.09.012 ER - TY - JOUR T1 - Response to "Comment on 'Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures'". AN - 1834999165; 27801650 JF - Environmental health perspectives AU - Parks, Christine G AU - Hoppin, Jane A AU - De Roos, Anneclaire J AU - Costenbader, Karen H AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/11/01/ PY - 2016 DA - 2016 Nov 01 SP - 1 VL - 124 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1834999165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Response+to+%22Comment+on+%27Rheumatoid+Arthritis+in+Agricultural+Health+Study+Spouses%3A+Associations+with+Pesticides+and+Other+Farm+Exposures%27%22.&rft.au=Parks%2C+Christine+G%3BHoppin%2C+Jane+A%3BDe+Roos%2C+Anneclaire+J%3BCostenbader%2C+Karen+H%3BSandler%2C+Dale+P&rft.aulast=Parks&rft.aufirst=Christine&rft.date=2016-11-01&rft.volume=124&rft.issue=11&rft.spage=A197&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Attentional bias training in girls at risk for depression AN - 1834802416 AB - Background This study examined, for the first time, whether attentional biases can be modified in adolescents at risk for depression. Methods The final sample consisted of 41 girls at familial risk for depression, who were randomly assigned to receive six sessions (864 trials) of real or sham attention bias training [Real attentional bias training (ABT) vs. Sham ABT]. Participants who received Real ABT completed a modified dot-probe task designed to train attention toward positive and away from negative facial expressions; in contrast, girls who received Sham ABT completed the standard dot-probe task. Attentional biases, self-reported mood, and psychophysiological responses to stress were measured at pre- and post-training assessments. Results As expected, girls who received Real ABT, but not those who received Sham ABT, exhibited significant increases from pre- to post-training in their attention toward happy faces and away from sad faces. Moreover, adolescents who received Real ABT were buffered against the negative outcomes experienced by adolescents who received Sham ABT. Specifically, only adolescents who received Sham ABT experienced an increase in negative mood and a pre- to post-training increase in heart rate in anticipation of the stressor. Conclusions The current findings provide the first experimental evidence that attentional biases can be modified in youth at risk for depression and further suggest that ABT modulates the heightened response to stress that is otherwise experienced by high-risk adolescents. JF - Journal of Child Psychology and Psychiatry AU - LeMoult, Joelle AU - Joormann, Jutta AU - Kircanski, Katharina AU - Gotlib, Ian H AD - Department of Psychology, Stanford University, California, CA, USA ; Department of Psychology, Yale University, New Haven, CT, USA ; Department of Health and Human Services, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA ; Department of Psychology, Stanford University, California, CA, USA Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 1326 EP - 1333 CY - Malden PB - Wiley Subscription Services, Inc. VL - 57 IS - 11 KW - Psychology KW - Bias KW - Teenagers KW - Heart rate KW - High risk KW - Psychophysiological aspects KW - Attentional bias KW - At risk KW - Facial expressions KW - Familial factors KW - Depression KW - First time KW - Adolescents KW - Girls UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1834802416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Attentional+bias+training+in+girls+at+risk+for+depression&rft.au=LeMoult%2C+Joelle%3BJoormann%2C+Jutta%3BKircanski%2C+Katharina%3BGotlib%2C+Ian+H&rft.aulast=LeMoult&rft.aufirst=Joelle&rft.date=2016-11-01&rft.volume=57&rft.issue=11&rft.spage=1326&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Psychology+and+Psychiatry&rft.issn=&rft_id=info:doi/10.1111%2Fjcpp.12587 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © 2016 Association for Child and Adolescent Mental Health. N1 - Last updated - 2017-01-26 DO - http://dx.doi.org/10.1111/jcpp.12587 ER - TY - JOUR T1 - Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F sub(1) mice AN - 1827934489; PQ0003704418 AB - The present study aimed to identify molecular markers of early stages of cardiotoxicity induced by a potent chemotherapeutic agent, doxorubicin (DOX). Male B6C3F sub(1) mice were dosed with 3mgkg super(-1) DOX or saline via tail vein weekly for 2, 3, 4, 6 or 8weeks (cumulative DOX doses of 6, 9, 12, 18 or 24mgkg super(-1), respectively) and euthanized a week after the last dose. Mass spectrometry-based and nuclear magnetic resonance spectrometry-based metabolic profiling were employed to identify initial biomarkers of cardiotoxicity before myocardial injury and cardiac pathology, which were not noted until after the 18 and 24mgkg super(-1) cumulative doses, respectively. After a cumulative dose of 6mgkg super(-1), 18 amino acids and four biogenic amines (acetylornithine, kynurenine, putrescine and serotonin) were significantly increased in cardiac tissue; 16 amino acids and two biogenic amines (acetylornithine and hydroxyproline) were significantly altered in plasma. In addition, 16 acylcarnitines were significantly increased in plasma and five were significantly decreased in cardiac tissue compared to saline-treated controls. Plasma lactate and succinate, involved in the Krebs cycle, were significantly altered after a cumulative dose of 6mgkg super(-1). A few metabolites remained altered at higher cumulative DOX doses, which could partly indicate a transition from injury processes at 2weeks to repair processes with additional injury happening concurrently before myocardial injury at 8weeks. These altered metabolic profiles in mouse heart and plasma during the initial stages of injury progression due to DOX treatment may suggest these metabolites as candidate early biomarkers of cardiotoxicity. Metabolomics analyses of plasma and heart tissue from male B6C3F sub(1) mice dosed weekly with 3mgkg super(-1) doxorubicin or saline for 2, 3, 4, 6 or 8weeks (cumulative doses of 6, 9, 12, 18 and 24mgkg super(-1), respectively) identified potential early stage injury biomarkers of doxorubicin-induced cardiotoxicity. Select metabolites were altered after the 6mgkg super(-1) cumulative dose whereas myocardial injury and cardiac pathology were not noted until after the 18 and 24mgkg super(-1) cumulative doses, respectively. JF - Journal of Applied Toxicology AU - Schnackenberg, Laura K AU - Pence, Lisa AU - Vijay, Vikrant AU - Moland, Carrie L AU - George, Nysia AU - Cao, Zhijun AU - Yu, Li-Rong AU - Fuscoe, James C AU - Beger, Richard D AU - Desai, Varsha G AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, Jefferson, Arkansas, 72079, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1486 EP - 1495 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 36 IS - 11 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - Pathology KW - Injuries KW - Chemotherapy KW - Metabolites KW - Veins KW - N.M.R. KW - NMR KW - Tricarboxylic acid cycle KW - Bioindicators KW - Biogenic amines KW - Heart KW - Hydroxyproline KW - Amino acids KW - Mice KW - Amines KW - biomarkers KW - Serotonin KW - Doxorubicin KW - Putrescine KW - Lactic acid KW - metabolomics KW - X 24390:Radioactive Materials KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827934489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Early+metabolomics+changes+in+heart+and+plasma+during+chronic+doxorubicin+treatment+in+B6C3F+sub%281%29+mice&rft.au=Schnackenberg%2C+Laura+K%3BPence%2C+Lisa%3BVijay%2C+Vikrant%3BMoland%2C+Carrie+L%3BGeorge%2C+Nysia%3BCao%2C+Zhijun%3BYu%2C+Li-Rong%3BFuscoe%2C+James+C%3BBeger%2C+Richard+D%3BDesai%2C+Varsha+G&rft.aulast=Schnackenberg&rft.aufirst=Laura&rft.date=2016-11-01&rft.volume=36&rft.issue=11&rft.spage=1486&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3307 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Heart; Biogenic amines; Hydroxyproline; Amino acids; Injuries; Chemotherapy; Metabolites; biomarkers; Doxorubicin; Serotonin; Veins; Putrescine; Lactic acid; N.M.R.; Tricarboxylic acid cycle; metabolomics; Bioindicators; Pathology; Mice; NMR; Amines DO - http://dx.doi.org/10.1002/jat.3307 ER - TY - JOUR T1 - The Perils of Integrating Wellness and Safety and Health and the Possibility of a Worker-Oriented Alternative AN - 1826876515 AB - In response to the article by Michael B. Lax, MD entitled "The perils of integrating wellness and safety and health and the possibility of a worker-oriented alternative," the National Institute for Occupational Safety and Health (NIOSH) provides updated information on the current focus and priorities and addresses concerns raised regarding the Total Worker Health® initiative. Many of the concerns and criticisms in the report echo those NIOSH publicly shares on a regular basis. The theory and practice of Total Worker Health (TWH) continues to evolve in response to valuable stakeholder input like that provided by Dr. Lax. In 2015, NIOSH updated the TWH concept to emphasize the main focus of TWH is the primacy of traditional health protection which prioritizes employer responsibilities for the organization of work over individual worker health behaviors. NIOSH acknowledges the past lack of "fit" between theory and practice in some publications of TWH-funded grantees as Dr. Lax points out. NIOSH is hopeful that the solicitation of new research, which is now underway, will clarify the work-centered priorities for TWH-funded research. Based on input from Dr. Lax and other stakeholders, NIOSH looks forward to contributing more effectively to protecting and promoting worker safety and health in the new twenty-first century world of work. JF - New Solutions : a Journal of Environmental and Occupational Health Policy : NS AU - Howard, John AU - Chosewood, L Casey AU - Hudson, Heidi L AD - National Institute for Occupational Safety and Health, Office of the Director, Washington, DC, USA ; National Institute for Occupational Safety and Health, Office for Total Worker Health, Atlanta, GA, USA ; National Institute for Occupational Safety and Health, Office for Total Worker Health, Cincinnati, OH, USA ; National Institute for Occupational Safety and Health, Office of the Director, Washington, DC, USA Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 345 EP - 348 CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 26 IS - 3 SN - 1048-2911 KW - Environmental Studies KW - total worker health KW - worksite wellness KW - integration of worksite health promotion and health protection KW - worker well-being KW - Employers KW - Publications KW - Work KW - Interest Groups KW - Occupational Safety and Health KW - Environmental Policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826876515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Application+of+a+Probabilistic+Framework+to+a+Biologically+Based+Dose-Response+Pregnancy+Model+to+Evaluate+Thyroidal+Effects+for+Environmental+Exposures+to+Perchlorate&rft.au=Lumen%2C+A&rft.aulast=Lumen&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Name - National Institute for Occupational Safety & Health N1 - Copyright - © The Author(s) 2016 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1177/1048291116656631 ER - TY - JOUR T1 - Ambient Air Pollution Exposures and Risk of Parkinson Disease. AN - 1826702958; 27285422 AB - Few epidemiologic studies have evaluated the effects of air pollution on the risk of Parkinson disease (PD). We investigated the associations of long-term residential concentrations of ambient particulate matter (PM) < 10 μm in diameter (PM10) and < 2.5 μm in diameter (PM2.5) and nitrogen dioxide (NO2) in relation to PD risk. Our nested case-control analysis included 1,556 self-reported physician-diagnosed PD cases identified between 1995 and 2006 and 3,313 controls frequency-matched on age, sex, and race. We geocoded home addresses reported in 1995-1996 and estimated the average ambient concentrations of PM10, PM2.5, and NO2 using a national fine-scale geostatistical model incorporating roadway information and other geographic covariates. Air pollutant exposures were analyzed as both quintiles and continuous variables, adjusting for matching variables and potential confounders. We observed no statistically significant overall association between PM or NO2 exposures and PD risk. However, in preplanned subgroup analyses, a higher risk of PD was associated with higher exposure to PM10 (ORQ5 vs. Q1 = 1.65; 95% CI: 1.11, 2.45; p-trend = 0.02) among women, and with higher exposure to PM2.5 (ORQ5 vs. Q1 = 1.29; 95% CI: 0.94, 1.76; p-trend = 0.04) among never smokers. In post hoc analyses among female never smokers, both PM2.5 (ORQ5 vs. Q1 = 1.79; 95% CI: 1.01, 3.17; p-trend = 0.05) and PM10 (ORQ5 vs. Q1 = 2.34; 95% CI: 1.29, 4.26; p-trend = 0.01) showed positive associations with PD risk. Analyses based on continuous exposure variables generally showed similar but nonsignificant associations. Overall, we found limited evidence for an association between exposures to ambient PM10, PM2.5, or NO2 and PD risk. The suggestive evidence that exposures to PM2.5 and PM10 may increase PD risk among female never smokers warrants further investigation. Citation: Liu R, Young MT, Chen JC, Kaufman JD, Chen H. 2016. Ambient air pollution exposures and risk of Parkinson disease. Environ Health Perspect 124:1759-1765; http://dx.doi.org/10.1289/EHP135. JF - Environmental health perspectives AU - Liu, Rui AU - Young, Michael T AU - Chen, Jiu-Chiuan AU - Kaufman, Joel D AU - Chen, Honglei AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1759 EP - 1765 VL - 124 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826702958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Ambient+Air+Pollution+Exposures+and+Risk+of+Parkinson+Disease.&rft.au=Liu%2C+Rui%3BYoung%2C+Michael+T%3BChen%2C+Jiu-Chiuan%3BKaufman%2C+Joel+D%3BChen%2C+Honglei&rft.aulast=Liu&rft.aufirst=Rui&rft.date=2016-11-01&rft.volume=124&rft.issue=11&rft.spage=1759&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 ER - TY - JOUR T1 - Nitrate from Drinking Water and Diet and Bladder Cancer Among Postmenopausal Women in Iowa. AN - 1826700831; 27258851 AB - Nitrate is a drinking water contaminant arising from agricultural sources, and it is a precursor in the endogenous formation of N-nitroso compounds (NOC), which are possible bladder carcinogens. We investigated the ingestion of nitrate and nitrite from drinking water and diet and bladder cancer risk in women. We identified incident bladder cancers among a cohort of 34,708 postmenopausal women in Iowa (1986-2010). Dietary nitrate and nitrite intakes were estimated from a baseline food frequency questionnaire. Drinking water source and duration were assessed in a 1989 follow-up. For women using public water supplies (PWS) > 10 years (n = 15,577), we estimated average nitrate (NO3-N) and total trihalomethane (TTHM) levels and the number of years exceeding one-half the maximum contaminant level (NO3-N: 5 mg/L, TTHM: 40 μg/mL) from historical monitoring data. We computed hazard ratios (HRs) and 95% confidence intervals (CIs), and assessed nitrate interactions with TTHM and with modifiers of NOC formation (smoking, vitamin C). We identified 258 bladder cancer cases, including 130 among women > 10 years at their PWS. In multivariable-adjusted models, we observed nonsignificant associations among women in the highest versus lowest quartile of average drinking water nitrate concentration (HR = 1.48; 95% CI: 0.92, 2.40; ptrend = 0.11), and we found significant associations among those exposed ≥ 4 years to drinking water with > 5 mg/L NO3-N (HR = 1.62; 95% CI: 1.06, 2.47; ptrend = 0.03) compared with women having 0 years of comparable exposure. TTHM adjustment had little influence on associations, and we observed no modification by vitamin C intake. Relative to a common reference group of never smokers with the lowest nitrate exposures, associations were strongest for current smokers with the highest nitrate exposures (HR = 3.67; 95% CI: 1.43, 9.38 for average water NO3-N and HR = 3.48; 95% CI: 1.20, 10.06 and ≥ 4 years > 5 mg/L, respectively). Dietary nitrate and nitrite intakes were not associated with bladder cancer. Long-term ingestion of elevated nitrate in drinking water was associated with an increased risk of bladder cancer among postmenopausal women. Citation: Jones RR, Weyer PJ, DellaValle CT, Inoue-Choi M, Anderson KE, Cantor KP, Krasner S, Robien K, Beane Freeman LE, Silverman DT, Ward MH. 2016. Nitrate from drinking water and diet and bladder cancer among postmenopausal women in Iowa. Environ Health Perspect 124:1751-1758; http://dx.doi.org/10.1289/EHP191. JF - Environmental health perspectives AU - Jones, Rena R AU - Weyer, Peter J AU - DellaValle, Curt T AU - Inoue-Choi, Maki AU - Anderson, Kristin E AU - Cantor, Kenneth P AU - Krasner, Stuart AU - Robien, Kim AU - Freeman, Laura E Beane AU - Silverman, Debra T AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1751 EP - 1758 VL - 124 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826700831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Regulatory+Perspective+for+Nonclinical+Development+and+Safety+Assessment+of+Antibody-+Drug+Conjugates&rft.au=Ricci%2C+S&rft.aulast=Ricci&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures. AN - 1826699916; 27285288 AB - Farming has been associated with rheumatoid arthritis (RA), but the role of pesticides is not known. We examined associations between RA and pesticides or other agricultural exposures among female spouses of licensed pesticide applicators in the Agricultural Health Study. Women were enrolled between 1993 and 1997 and followed through 2010. Cases (n = 275 total, 132 incident), confirmed by a physician or by self-reported use of disease modifying antirheumatic drugs, were compared with noncases (n = 24,018). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models adjusted for age, state, and smoking pack-years. Overall, women with RA were somewhat more likely to have reported lifetime use of any specific pesticide versus no pesticides (OR = 1.4; 95% CI: 1.0, 1.6). Of the 15 pesticides examined, maneb/mancozeb (OR = 3.3; 95% CI: 1.5, 7.1) and glyphosate (OR = 1.4; 95% CI: 1.0, 2.1) were associated with incident RA compared with no pesticide use. An elevated, but non-statistically significant association with incident RA was seen for DDT (OR = 1.9; 95% CI: 0.97, 3.6). Incident RA was also associated with the application of chemical fertilizers (OR = 1.7; 95% CI: 1.1, 2.7) and cleaning with solvents (OR = 1.6; 95% CI: 1.1, 2.4), but inversely associated with lifetime livestock exposure as a child and adult (OR = 0.48; 95% CI: 0.24, 0.97) compared with no livestock exposure. Our results suggest that specific agricultural pesticides, solvents, and chemical fertilizers may increase the risk of RA in women, while exposures involving animal contact may be protective. Citation: Parks CG, Hoppin JA, De Roos AJ, Costenbader KH, Alavanja MC, Sandler DP. 2016. Rheumatoid arthritis in Agricultural Health Study spouses: associations with pesticides and other farm exposures. Environ Health Perspect 124:1728-1734; http://dx.doi.org/10.1289/EHP129. JF - Environmental health perspectives AU - Parks, Christine G AU - Hoppin, Jane A AU - De Roos, Anneclaire J AU - Costenbader, Karen H AU - Alavanja, Michael C AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1728 EP - 1734 VL - 124 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826699916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Rheumatoid+Arthritis+in+Agricultural+Health+Study+Spouses%3A+Associations+with+Pesticides+and+Other+Farm+Exposures.&rft.au=Parks%2C+Christine+G%3BHoppin%2C+Jane+A%3BDe+Roos%2C+Anneclaire+J%3BCostenbader%2C+Karen+H%3BAlavanja%2C+Michael+C%3BSandler%2C+Dale+P&rft.aulast=Parks&rft.aufirst=Christine&rft.date=2016-11-01&rft.volume=124&rft.issue=11&rft.spage=1728&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Distance to testing sites and its association with timing of HIV diagnosis AN - 1818448099 AB - Early HIV diagnosis enables prompt treatment initiation, thereby contributing to decreased morbidity, mortality, and transmission. We aimed to describe the association between distance from residence to testing sites and HIV disease stage at diagnosis. Using HIV surveillance data, we identified all new HIV diagnoses made at publicly funded testing sites in central North Carolina during 2005-2013. Early-stage HIV was defined as acute HIV (antibody-negative test with a positive HIV RNA) or recent HIV (normalized optical density <0.8 on the BED assay for non-AIDS cases); remaining diagnoses were considered post-early-stage HIV. Street distance between residence at diagnosis and (1) the closest testing site and (2) the diagnosis site was dichotomized at 5 miles. We fit log-binomial models using generalized estimating equations to estimate prevalence ratios (PR) and robust 95% confidence intervals (CI) for post-early-stage diagnoses by distance. Models were adjusted for race/ethnicity and testing period. Most of the 3028 new diagnoses were black (N = 2144; 70.8%), men who have sex with men (N = 1685; 55.7%), and post-early-stage HIV diagnoses (N = 2010; 66.4%). Overall, 1145 (37.8%) cases traveled <5 miles for a diagnosis. Among cases traveling [greater than or equal to]5 miles for a diagnosis, 1273 (67.6%) lived <5 miles from a different site. Residing [greater than or equal to]5 miles from a testing site was not associated with post-early-stage HIV (adjusted PR, 95% CI: 0.98, 0.92-1.04), but traveling [greater than or equal to]5 miles for a diagnosis was associated with higher post-early HIV prevalence (1.07, 1.02-1.13). Most of the elevated prevalence observed in cases traveling [greater than or equal to]5 miles for a diagnosis occurred among those living <5 miles from a different site (1.09, 1.03-1.16). Modest increases in post-early-stage HIV diagnosis were apparent among persons living near a site, but choosing to travel longer distances to test. Understanding reasons for increased travel distances could improve accessibility and acceptability of HIV services and increase early diagnosis rates. JF - AIDS Care AU - Cope, Anna B AU - Powers, Kimberly A AU - Serre, Marc L AU - Escamilla, Veronica AU - Emch, Michael E AU - Leone, Peter A AU - Mobley, Victoria L AU - Miller, William C AD - Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA ; Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, USA ; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA; Department of Geography, University of North Carolina, Chapel Hill, NC, USA ; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ; North Carolina Department of Health and Human Services, Raleigh, NC, USA ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 1423 EP - 1427 CY - London PB - Taylor & Francis Ltd. VL - 28 IS - 11 SN - 0954-0121 KW - Medical Sciences--Psychiatry And Neurology KW - Recent HIV infection KW - surveillance KW - HIV testing KW - geographic distance KW - barriers to testing KW - late diagnosis KW - Diagnostic testing KW - Accessibility KW - Morbidity-Mortality KW - Mortality KW - AIDS KW - Residence KW - Density KW - Morbidity KW - Confidence intervals KW - Ethnicity KW - HIV KW - Surveillance KW - Homosexuals KW - Men KW - Race KW - Diagnosis KW - Timing KW - Initiation KW - Human immunodeficiency virus--HIV KW - Acquired immune deficiency syndrome--AIDS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1818448099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Distance+to+testing+sites+and+its+association+with+timing+of+HIV+diagnosis&rft.au=Cope%2C+Anna+B%3BPowers%2C+Kimberly+A%3BSerre%2C+Marc+L%3BEscamilla%2C+Veronica%3BEmch%2C+Michael+E%3BLeone%2C+Peter+A%3BMobley%2C+Victoria+L%3BMiller%2C+William+C&rft.aulast=Cope&rft.aufirst=Anna&rft.date=2016-11-01&rft.volume=28&rft.issue=11&rft.spage=1423&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2016.1191599 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © 2016 Informa UK Limited, trading as Taylor & Francis Group N1 - Last updated - 2016-09-12 DO - http://dx.doi.org/10.1080/09540121.2016.1191599 ER - TY - JOUR T1 - Size- and coating-dependent cytotoxicity and genotoxicity of silver nanoparticles evaluated using in vitro standard assays. AN - 1814659617; 27441588 AB - The physicochemical characteristics of silver nanoparticles (AgNPs) may greatly alter their toxicological potential. To explore the effects of size and coating on the cytotoxicity and genotoxicity of AgNPs, six different types of AgNPs, having three different sizes and two different coatings, were investigated using the Ames test, mouse lymphoma assay (MLA) and in vitro micronucleus assay. The genotoxicities of silver acetate and silver nitrate were evaluated to compare the genotoxicity of nanosilver to that of ionic silver. The Ames test produced inconclusive results for all types of the silver materials due to the high toxicity of silver to the test bacteria and the lack of entry of the nanoparticles into the cells. Treatment of L5718Y cells with AgNPs and ionic silver resulted in concentration-dependent cytotoxicity, mutagenicity in the Tk gene and the induction of micronuclei from exposure to nearly every type of the silver materials. Treatment of TK6 cells with these silver materials also resulted in concentration-dependent cytotoxicity and significantly increased micronucleus frequency. With both the MLA and micronucleus assays, the smaller the AgNPs, the greater the cytotoxicity and genotoxicity. The coatings had less effect on the relative genotoxicity of AgNPs than the particle size. Loss of heterozygosity analysis of the induced Tk mutants indicated that the types of mutations induced by AgNPs were different from those of ionic silver. These results suggest that AgNPs induce cytotoxicity and genotoxicity in a size- and coating-dependent manner. Furthermore, while the MLA and in vitro micronucleus assay (in both types of cells) are useful to quantitatively measure the genotoxic potencies of AgNPs, the Ames test cannot. JF - Nanotoxicology AU - Guo, Xiaoqing AU - Li, Yan AU - Yan, Jian AU - Ingle, Taylor AU - Jones, Margie Yvonne AU - Mei, Nan AU - Boudreau, Mary D AU - Cunningham, Candice K AU - Abbas, Mazhar AU - Paredes, Angel M AU - Zhou, Tong AU - Moore, Martha M AU - Howard, Paul C AU - Chen, Tao AD - a Division of Genetic and Molecular Toxicology . ; b Nanotechnology Core Facility , and. ; c Division of Biochemical Toxicology , National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson , AR , USA . ; e Center for Veterinary Medicine, U.S. Food and Drug Administration , Rockville , MD , USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1373 EP - 1384 VL - 10 IS - 9 KW - Index Medicus KW - genotoxicity KW - in vitro micronucleus assay KW - Ames test KW - mouse lymphoma assay KW - silver nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814659617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Size-+and+coating-dependent+cytotoxicity+and+genotoxicity+of+silver+nanoparticles+evaluated+using+in+vitro+standard+assays.&rft.au=Guo%2C+Xiaoqing%3BLi%2C+Yan%3BYan%2C+Jian%3BIngle%2C+Taylor%3BJones%2C+Margie+Yvonne%3BMei%2C+Nan%3BBoudreau%2C+Mary+D%3BCunningham%2C+Candice+K%3BAbbas%2C+Mazhar%3BParedes%2C+Angel+M%3BZhou%2C+Tong%3BMoore%2C+Martha+M%3BHoward%2C+Paul+C%3BChen%2C+Tao&rft.aulast=Guo&rft.aufirst=Xiaoqing&rft.date=2016-11-01&rft.volume=10&rft.issue=9&rft.spage=1373&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.1080%2F17435390.2016.1214764 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/17435390.2016.1214764 ER - TY - JOUR T1 - Improving drug safety with a systems pharmacology approach. AN - 1826702552; 27287422 AB - Systems pharmacology is used to mechanistically analyze drug-adverse drug reaction (ADRs) pairs and is a promising solution to the complex problem of understanding mechanisms of toxicity. In this research, we have explored the feasibility of retrospectively mapping population-level adverse events from the FDA Adverse Event Reporting System (FAERS) to chemical and biological databases to identify drug safety signals and the underlying molecular mechanisms. We used an analytic platform - Molecular Analysis of Side Effects (MASE™). For this purpose, we selected the adverse event of severe and potentially fatal cutaneous reactions (SCARs) that are associated with acetaminophen (APAP). SCARs encompass the continuum between Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). We found a statistically significant association between APAP and TEN, the most severe form of SCARs. We also explored the influence of APAP on other classes of drugs commonly associated with SCARs. We found that APAP significantly reduced the risk of SCARs commonly associated with carbamazepine (CBZ). We used molecular docking simulations to propose a mechanism for APAP's reduction in CBZ-induced SCARs which is competitive inhibition of the binding of CBZ to HLA-B*15:02. We conclude that systems pharmacology can complement established surveillance methodologies by providing a means to undertake an independent investigation and review of the mechanisms by which drugs cause adverse events. Copyright © 2016. Published by Elsevier B.V. JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences AU - Schotland, Peter AU - Bojunga, Niels AU - Zien, Alexander AU - Trame, Mirjam Nadine AU - Lesko, Lawrence J AD - The Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, United States; Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, United States. ; Molecular Health, Heidelberg, Germany. ; The Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, United States. ; The Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, United States. Electronic address: llesko@cop.ufl.edu. Y1 - 2016/10/30/ PY - 2016 DA - 2016 Oct 30 SP - 84 EP - 92 VL - 94 KW - Systems pharmacology KW - Informatics KW - Stevens-Johnson Syndrome KW - Drug safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826702552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmaceutical+sciences+%3A+official+journal+of+the+European+Federation+for+Pharmaceutical+Sciences&rft.atitle=Improving+drug+safety+with+a+systems+pharmacology+approach.&rft.au=Roberts%2C+J%3BErdely%2C+A&rft.aulast=Roberts&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ejps.2016.06.009 ER - TY - JOUR T1 - Concentrations of Polychlorinated Biphenyls and Organochlorine Pesticides in Umbilical Cord Blood Serum of Newborns in Kingston, Jamaica. AN - 1835511789; 27775677 AB - To date much of the biomonitoring related to exposure to polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides is from middle to high income countries, including the U.S., Canada and Europe, but such data are lacking for the majority of low to middle income countries. Using data from 64 pregnant mothers who were enrolled in 2011, we aimed to assess the concentrations of the aforementioned toxins in umbilical cord blood serum of 67 Jamaican newborns. For 97 of the 100 PCB congeners and 16 of the 17 OC pesticides, all (100%) concentrations were below their respective limits of detection (LOD). Mean (standard deviation (SD)) lipid-adjusted concentrations in cord blood serum for congeners PCB-153, PCB-180, PCB-206 and total PCB were 14.25 (3.21), 7.16 (1.71), 7.30 (1.74) and 28.15 (6.03) ng/g-lipid, respectively. The means (SD) for the 4,4'-dichlorodiphenyldichloroethylene (DDE)-hexane fraction and total-DDE were 61.61 (70.78) and 61.60 (70.76) ng/g-lipid, respectively. Compared to the U.S. and Canada, the concentrations of these toxins were lower in cord-blood serum of Jamaican newborns. We discuss that these differences could be partly due to differences in dietary patterns in these countries. Despite limitations in our dataset, our results provide information on the investigated toxins in cord blood serum that could serve as a reference for Jamaican newborns. JF - International journal of environmental research and public health AU - Rahbar, Mohammad H AU - Samms-Vaughan, Maureen AU - Hessabi, Manouchehr AU - Dickerson, Aisha S AU - Lee, MinJae AU - Bressler, Jan AU - Tomechko, Sara E AU - Moreno, Emily K AU - Loveland, Katherine A AU - Desai, Charlene Coore AU - Shakespeare-Pellington, Sydonnie AU - Reece, Jody-Ann AU - Morgan, Renee AU - Geiger, Matthew J AU - O'Keefe, Michael E AU - Grove, Megan L AU - Boerwinkle, Eric AD - Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Mohammad.H.Rahbar@uth.tmc.edu. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. msammsvaughan@gmail.com. ; Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Manouchehr.Hessabi@uth.tmc.edu. ; Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, TX 77030, USA. adickerson@hsph.harvard.edu. ; Division of Clinical and Translational Sciences, Department of Internal Medicine, University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA. MinJae.Lee@uth.tmc.edu. ; Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Jan.Bressler@uth.tmc.edu. ; Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. sara.tomechko@gmail.com. ; Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. MorenoE@michigan.gov. ; Department of Psychiatry and Behavioral Sciences, University of Texas McGovern Medical School at Houston, Houston, TX 77054, USA. Katherine.A.Loveland@uth.tmc.edu. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. cooredesai@googlemail.com. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. sydonniesp@gmail.com. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. jodyreece@yahoo.com. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. renee.n.morgan@gmail.com. ; Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. geigerm@michigan.gov. ; Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. okeefem@michigan.gov. ; Human Genetics Center, University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Megan.L.Grove@uth.tmc.edu. ; Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Eric.Boerwinkle@uth.tmc.edu. Y1 - 2016/10/21/ PY - 2016 DA - 2016 Oct 21 VL - 13 IS - 10 KW - polychlorinated biphenyls (PCBs) KW - organochlorine (OC) pesticides KW - Jamaica KW - newborns KW - Kingston UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835511789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Concentrations+of+Polychlorinated+Biphenyls+and+Organochlorine+Pesticides+in+Umbilical+Cord+Blood+Serum+of+Newborns+in+Kingston%2C+Jamaica.&rft.au=Rahbar%2C+Mohammad+H%3BSamms-Vaughan%2C+Maureen%3BHessabi%2C+Manouchehr%3BDickerson%2C+Aisha+S%3BLee%2C+MinJae%3BBressler%2C+Jan%3BTomechko%2C+Sara+E%3BMoreno%2C+Emily+K%3BLoveland%2C+Katherine+A%3BDesai%2C+Charlene+Coore%3BShakespeare-Pellington%2C+Sydonnie%3BReece%2C+Jody-Ann%3BMorgan%2C+Renee%3BGeiger%2C+Matthew+J%3BO%27Keefe%2C+Michael+E%3BGrove%2C+Megan+L%3BBoerwinkle%2C+Eric&rft.aulast=Rahbar&rft.aufirst=Mohammad&rft.date=2016-10-21&rft.volume=13&rft.issue=10&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Exploring Oxidative Reactions in Hemoglobin Variants Using Mass Spectrometry: Lessons for Engineering Oxidatively Stable Oxygen Therapeutics. AN - 1835503592; 27626360 AB - Worldwide demand has driven the development of hemoglobin (Hb)-based oxygen carriers (HBOCs) as potential acellular oxygen therapeutics. HBOCs have the potential to provide an oxygen bridge to patients and minimize current problems associated with supply and storage of donated blood. However, to date, safety and efficacy issues have hampered the approval of viable HBOCs in the United States. These previous efforts have underscored the need for a better molecular understanding of toxicity to design safe and oxidatively stable HBOCs. Recent Advances: High-resolution accurate mass (HRAM) mass spectrometry (MS) has recently become a versatile tool in characterizing oxidative post-translational modifications that occur in Hb. When integrated with other analytical techniques, HRAM data have been invaluable in providing mechanistic insight into the extent of oxidative modification by quantifying oxidation in amino acids near the reactive heme or at specific "oxidative hotspots." In addition to providing a deeper understanding of Hb oxidative toxicity, HRAM MS studies are currently being used toward developing suitable HBOCs using a "two-prong" strategy that involves (i) understanding the mechanism of Hb toxicity by evaluating mutant Hbs identified in patients with hemoglobinopathies and (ii) utilizing this information toward designing against (or for) these reactions in acellular oxygen therapeutics that will result in oxidatively stable protein. Future HRAM studies are aimed at fully characterizing engineered candidate HBOCs to determine the most oxidatively stable protein while retaining oxygen carrying function in vivo. Antioxid. Redox Signal. 00, 000-000. JF - Antioxidants & redox signaling AU - Strader, Michael Brad AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research , Food and Drug Administration, Silver Spring, Maryland. Y1 - 2016/10/20/ PY - 2016 DA - 2016 Oct 20 KW - mass spectrometry KW - oxidation reactions KW - hemoglobin mutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835503592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Exploring+Oxidative+Reactions+in+Hemoglobin+Variants+Using+Mass+Spectrometry%3A+Lessons+for+Engineering+Oxidatively+Stable+Oxygen+Therapeutics.&rft.au=Strader%2C+Michael+Brad%3BAlayash%2C+Abdu+I&rft.aulast=Strader&rft.aufirst=Michael&rft.date=2016-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=1557-7716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Occurrence of aflatoxin B1 in baby foods marketed in Iran. AN - 1835438948; 27747874 AB - Aflatoxin B1 (AFB1 ), a toxic fungal metabolite that is found in baby foods, can lead to serious complications for children's health. In the present study, 48 commercial baby foods available in the Iranian market were investigated for the presence of AFB1 using a high performance liquid chromatography system that was equipped with post-column photochemical derivatization and a fluorescence detector. Thirty-three out of 48 samples (68.7%) were contaminated with AFB1 at median, maximum and mean concentration levels of 0.11, 15.15 and 2.602 ± 4.065 µg kg-1 , respectively. The AFB1 concentration in 39.6% of the samples was higher than the maximum level established in Iran for AFB1 within baby foods containing milk (0.5 µg kg-1 ). The incidence of AFB1 in rice, wheat and multigrain infant cereal samples was 90%, 25% and 100%, respectively, whereas rice-based baby foods contained the highest levels of AFB1 . In the present study, the finding of both high rates and high levels of AFB1 in cereal baby foods indicates the need to reduce AFB1 contamination in these products. Therefore, further monitoring and control of pre- and post-harvest, storage, and manufacturing processes is required. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry. JF - Journal of the science of food and agriculture AU - Mottaghianpour, Ehsan AU - Nazari, Firouzeh AU - Mehrasbi, Mohammad Reza AU - Hosseini, Mir-Jamal AD - Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran. ; Food and Drug Administration-Iran University of Medical Sciences, Tehran, Iran. ; Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran. Y1 - 2016/10/16/ PY - 2016 DA - 2016 Oct 16 KW - HPLC KW - aflatoxin B1 KW - Iran KW - baby foods KW - contamination KW - photochemical derivatization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835438948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+science+of+food+and+agriculture&rft.atitle=Occurrence+of+aflatoxin+B1+in+baby+foods+marketed+in+Iran.&rft.au=Mottaghianpour%2C+Ehsan%3BNazari%2C+Firouzeh%3BMehrasbi%2C+Mohammad+Reza%3BHosseini%2C+Mir-Jamal&rft.aulast=Mottaghianpour&rft.aufirst=Ehsan&rft.date=2016-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+science+of+food+and+agriculture&rft.issn=1097-0010&rft_id=info:doi/10.1002%2Fjsfa.8092 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jsfa.8092 ER - TY - JOUR T1 - Bacterial Populations Associated with Smokeless Tobacco Products. AN - 1835369408; 27565615 AB - There are an estimated 8 million users of smokeless tobacco products (STPs) in the United States, and yet limited data on microbial populations within these products exist. To better understand the potential microbiological risks associated with STP use, a study was conducted to provide a baseline microbiological profile of STPs. A total of 90 samples, representing 15 common STPs, were purchased in metropolitan areas in Little Rock, AR, and Washington, DC, in November 2012, March 2013, and July 2013. Bacterial populations were evaluated using culture, pyrosequencing, and denaturing gradient gel electrophoresis (DGGE). Moist-snuff products exhibited higher levels of bacteria (average of 1.05 × 106 CFU/g STP) and diversity of bacterial populations than snus (average of 8.33 × 101 CFU/g STP) and some chewing tobacco products (average of 2.54 × 105 CFU/g STP). The most common species identified by culturing were Bacillus pumilus, B. licheniformis, B. safensis, and B. subtilis, followed by members of the genera Oceanobacillus, Staphylococcus, and Tetragenococcus. Pyrosequencing analyses of the 16S rRNA genes identified the genera Tetragenococcus, Carnobacterium, Lactobacillus, Geobacillus, Bacillus, and Staphylococcus as the predominant taxa. Several species identified are of possible concern due to their potential to cause opportunistic infections and reported abilities to reduce nitrates to nitrites, which may be an important step in the formation of carcinogenic tobacco-specific N'-nitrosamines. This report provides a microbiological baseline to help fill knowledge gaps associated with microbiological risks of STPs and to inform potential regulations regarding manufacture and testing of STPs. It is estimated that there 8 million users of smokeless tobacco products (STPs) in the United States; however, there are limited data on microbial populations that exist within these products. The current study was undertaken to better understand the potential microbiological risks associated with STP use and provide a baseline microbiological profile of STPs. Several bacterial species were identified that are of possible concern due to their potential to cause opportunistic infections. In addition, some species have abilities to reduce nitrates to nitrites, which may be an important step in the formation of carcinogenic tobacco-specific N'-nitrosamines. Overall, this report provides a microbiological baseline to help fill knowledge gaps related to the microbiological risks of STPs and to inform potential regulations regarding the manufacture and testing of STPs. Copyright © 2016, American Society for Microbiology. All Rights Reserved. JF - Applied and environmental microbiology AU - Han, Jing AU - Sanad, Yasser M AU - Deck, Joanna AU - Sutherland, John B AU - Li, Zhong AU - Walters, Matthew J AU - Duran, Norma AU - Holman, Matthew R AU - Foley, Steven L AD - Division of Microbiology, FDA, National Center for Toxicological Research, Jefferson, Arkansas, USA. ; Division of Product Science, FDA, Center for Tobacco Products, Silver Spring, Maryland, USA. ; Division of Microbiology, FDA, National Center for Toxicological Research, Jefferson, Arkansas, USA steven.foley@fda.hhs.gov. Y1 - 2016/10/15/ PY - 2016 DA - 2016 Oct 15 SP - 6273 EP - 6283 VL - 82 IS - 20 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835369408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Bacterial+Populations+Associated+with+Smokeless+Tobacco+Products.&rft.au=Han%2C+Jing%3BSanad%2C+Yasser+M%3BDeck%2C+Joanna%3BSutherland%2C+John+B%3BLi%2C+Zhong%3BWalters%2C+Matthew+J%3BDuran%2C+Norma%3BHolman%2C+Matthew+R%3BFoley%2C+Steven+L&rft.aulast=Han&rft.aufirst=Jing&rft.date=2016-10-15&rft.volume=82&rft.issue=20&rft.spage=6273&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Acute Occupational Pesticide-Related Illness and Injury -United States, 2007-2011. AN - 1835427643; 27736824 AB - CDC's National Institute for Occupational Safety and Health (NIOSH) collects data on acute pesticide-related illness and injury reported by 12 states (California, Florida, Iowa, Louisiana, Michigan, Nebraska, North Carolina, New Mexico, New York, Oregon, Texas, and Washington). This report summarizes the data on illnesses and injuries arising from occupational exposure to conventional pesticides from 2007 through 2011. This report is a part of the Summary of Notifiable Noninfectious Conditions and Disease Outbreaks - United States, which encompasses various surveillance years but is being published in 2016 (1). The Summary of Notifiable Noninfectious Conditions and Disease Outbreaks appears in the same volume of MMWR as the annual Summary of Notifiable Infectious Diseases (2). In a separate report, data on illnesses and injuries from nonoccupational exposure to pesticides during 2007-2011 are summarized (3). JF - MMWR. Morbidity and mortality weekly report AU - Calvert, Geoffrey M AU - Beckman, John AU - Prado, Joanne Bonnar AU - Bojes, Heidi AU - Schwartz, Abby AU - Mulay, Prakash AU - Leinenkugel, Kathy AU - Higgins, Sheila AU - Lackovic, Michelle AU - Waltz, Justin AU - Stover, Derry AU - Moraga-McHaley, Stephanie AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC. ; Public Health Institute and Occupational Health Branch, California Department of Public Health, Richmond, California. ; Office of Environmental Health, Safety, and Toxicology, Washington State Department of Health, Olympia, Washington. ; Environmental and Injury Epidemiology and Toxicology Unit, Texas Department of State Health Services, Austin, Texas. ; Division of Environmental Health, Michigan Department of Health and Human Services, Lansing, Michigan. ; Florida Department of Health, Tallahassee, Florida. ; Iowa Department of Public Health, Des Moines, Iowa. ; North Carolina Department of Health and Human Services, Raleigh, North Carolina. ; Louisiana Department of Health and Hospitals, New Orleans, Louisiana. ; Center for Health Protection, Public Health Division, Oregon Health Authority, Portland, Oregon. ; Nebraska Department of Health and Human Services, Lincoln, Nebraska. ; New Mexico Department of Health, Albuquerque, New Mexico. Y1 - 2016/10/14/ PY - 2016 DA - 2016 Oct 14 SP - 11 EP - 16 VL - 63 IS - 55 KW - Pesticides KW - 0 KW - Index Medicus KW - Acute Disease KW - Humans KW - United States -- epidemiology KW - Male KW - Female KW - Occupational Injuries -- chemically induced KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Occupational Injuries -- epidemiology KW - Occupational Diseases -- chemically induced KW - Population Surveillance KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835427643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+mortality+weekly+report&rft.atitle=Acute+Occupational+Pesticide-Related+Illness+and+Injury+-United+States%2C+2007-2011.&rft.au=Calvert%2C+Geoffrey+M%3BBeckman%2C+John%3BPrado%2C+Joanne+Bonnar%3BBojes%2C+Heidi%3BSchwartz%2C+Abby%3BMulay%2C+Prakash%3BLeinenkugel%2C+Kathy%3BHiggins%2C+Sheila%3BLackovic%2C+Michelle%3BWaltz%2C+Justin%3BStover%2C+Derry%3BMoraga-McHaley%2C+Stephanie&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2016-10-14&rft.volume=63&rft.issue=55&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+mortality+weekly+report&rft.issn=1545-861X&rft_id=info:doi/10.15585%2Fmmwr.mm6355a3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-12 N1 - Date created - 2016-10-13 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.15585/mmwr.mm6355a3 ER - TY - JOUR T1 - Draft Genome Sequences of Four Salmonella enterica Strains Isolated from Turkey-Associated Sources. AN - 1835422505; 27738037 AB - We report the draft genomes of four Salmonella enterica isolates evaluated for the contribution of plasmids to virulence. Strains SE163A, SE696A, and SE710A carry plasmids demonstrated to facilitate plasmid-associated virulence, while SE819 is less virulent and has been used as a recipient for conjugation experiments to assess plasmid-encoded virulence mechanisms. Copyright © 2016 Khajanchi et al. JF - Genome announcements AU - Khajanchi, Bijay K AU - Han, Jing AU - Gokulan, Kuppan AU - Zhao, Shaohua AU - Gies, Allen AU - Foley, Steven L AD - U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, USA bijay.khajanchi@fda.hhs.gov steven.foley@fda.hhs.gov. ; U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, USA. ; U.S. Food and Drug Administration, Center for Veterinary Medicine, Laurel, Maryland, USA. ; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. Y1 - 2016/10/13/ PY - 2016 DA - 2016 Oct 13 VL - 4 IS - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835422505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+announcements&rft.atitle=Draft+Genome+Sequences+of+Four+Salmonella+enterica+Strains+Isolated+from+Turkey-Associated+Sources.&rft.au=Khajanchi%2C+Bijay+K%3BHan%2C+Jing%3BGokulan%2C+Kuppan%3BZhao%2C+Shaohua%3BGies%2C+Allen%3BFoley%2C+Steven+L&rft.aulast=Khajanchi&rft.aufirst=Bijay&rft.date=2016-10-13&rft.volume=4&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/genomeA.01122-16 ER - TY - JOUR T1 - Trastuzumab cardiotoxicity: from clinical trials to experimental studies. AN - 1835401094; 27714776 AB - Epidermal growth factor receptor-2 (HER-2) is overexpressed in 20 to 25% of human breast cancers, which is associated with aggressive tumour growth and poor prognosis. Trastuzumab (Herceptin®) is a humanized monoclonal antibody directed against HER-2, the first highly selective form of therapy targeting HER-2 overexpressing tumours. Although initial trials indicated high efficacy and a favourable safety profile of the drug, the first large, randomized trial prompted a retrospective analysis of cardiac dysfunction in earlier trials utilizing trastuzumab. There has been ongoing debate on the cardiac safety of trastuzumab ever since, initiating numerous clinical and preclinical investigations to better understand the background of trastuzumab cardiotoxicity and evaluate its effects on patient morbidity. Here, we have given a comprehensive overview of our current knowledge on the cardiotoxicity of trastuzumab, primarily focusing on data from clinical trials and highlighting the main molecular mechanisms proposed. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - British journal of pharmacology AU - Nemeth, Balazs T AU - Varga, Zoltan V AU - Wu, Wen Jin AU - Pacher, Pal AD - Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA. ; Division of Biotechnology Research and Review 1, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA. Y1 - 2016/10/07/ PY - 2016 DA - 2016 Oct 07 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835401094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+pharmacology&rft.atitle=Trastuzumab+cardiotoxicity%3A+from+clinical+trials+to+experimental+studies.&rft.au=Nemeth%2C+Balazs+T%3BVarga%2C+Zoltan+V%3BWu%2C+Wen+Jin%3BPacher%2C+Pal&rft.aulast=Nemeth&rft.aufirst=Balazs&rft.date=2016-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=British+journal+of+pharmacology&rft.issn=1476-5381&rft_id=info:doi/10.1111%2Fbph.13643 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/bph.13643 ER - TY - GEN T1 - Proceedings of the 2016 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. AN - 1835520081; 27766933 JF - BMC bioinformatics AU - Wren, Jonathan D AU - Toby, Inimary AU - Hong, Huxiao AU - Nanduri, Bindu AU - Kaundal, Rakesh AU - Dozmorov, Mikhail G AU - Thakkar, Shraddha Y1 - 2016/10/06/ PY - 2016 DA - 2016 Oct 06 SP - 356 VL - 17 KW - Conferences KW - ISCB KW - MCBIOS KW - Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835520081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=BMC+bioinformatics&rft.atitle=Proceedings+of+the+2016+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS%29+Conference.&rft.au=Wren%2C+Jonathan+D%3BToby%2C+Inimary%3BHong%2C+Huxiao%3BNanduri%2C+Bindu%3BKaundal%2C+Rakesh%3BDozmorov%2C+Mikhail+G%3BThakkar%2C+Shraddha&rft.aulast=Wren&rft.aufirst=Jonathan&rft.date=2016-10-06&rft.volume=17&rft.issue=&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=BMC+bioinformatics&rft.issn=1471-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-21 N1 - Date revised - 2017-02-08 N1 - Last updated - 2017-02-08 ER - TY - JOUR T1 - Application of dynamic topic models to toxicogenomics data. AN - 1835519794; 27766956 AB - All biological processes are inherently dynamic. Biological systems evolve transiently or sustainably according to sequential time points after perturbation by environment insults, drugs and chemicals. Investigating the temporal behavior of molecular events has been an important subject to understand the underlying mechanisms governing the biological system in response to, such as, drug treatment. The intrinsic complexity of time series data requires appropriate computational algorithms for data interpretation. In this study, we propose, for the first time, the application of dynamic topic models (DTM) for analyzing time-series gene expression data. A large time-series toxicogenomics dataset was studied. It contains over 3144 microarrays of gene expression data corresponding to rat livers treated with 131 compounds (most are drugs) at two doses (control and high dose) in a repeated schedule containing four separate time points (4-, 8-, 15- and 29-day). We analyzed, with DTM, the topics (consisting of a set of genes) and their biological interpretations over these four time points. We identified hidden patterns embedded in this time-series gene expression profiles. From the topic distribution for compound-time condition, a number of drugs were successfully clustered by their shared mode-of-action such as PPARɑ agonists and COX inhibitors. The biological meaning underlying each topic was interpreted using diverse sources of information such as functional analysis of the pathways and therapeutic uses of the drugs. Additionally, we found that sample clusters produced by DTM are much more coherent in terms of functional categories when compared to traditional clustering algorithms. We demonstrated that DTM, a text mining technique, can be a powerful computational approach for clustering time-series gene expression profiles with the probabilistic representation of their dynamic features along sequential time frames. The method offers an alternative way for uncovering hidden patterns embedded in time series gene expression profiles to gain enhanced understanding of dynamic behavior of gene regulation in the biological system. JF - BMC bioinformatics AU - Lee, Mikyung AU - Liu, Zhichao AU - Huang, Ruili AU - Tong, Weida AD - NIH/National Center for Advancing Translational Sciences, Rockville, MD, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, AR, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, AR, USA. weida.tong@fda.hhs.gov. Y1 - 2016/10/06/ PY - 2016 DA - 2016 Oct 06 SP - 368 VL - 17 KW - TG-GATEs KW - Dynamic topic model (DTM) KW - Latent Dirichlet model KW - Clustering KW - Topic modeling KW - Toxicogenomics KW - Times-series gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835519794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+bioinformatics&rft.atitle=Application+of+dynamic+topic+models+to+toxicogenomics+data.&rft.au=Lee%2C+Mikyung%3BLiu%2C+Zhichao%3BHuang%2C+Ruili%3BTong%2C+Weida&rft.aulast=Lee&rft.aufirst=Mikyung&rft.date=2016-10-06&rft.volume=17&rft.issue=&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=BMC+bioinformatics&rft.issn=1471-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - GEN T1 - State Regulations and Opioid Use among Disabled Adults. AN - 1835356303; 27705248 JF - The New England journal of medicine AU - Jones, Christopher M AU - Baldwin, Grant T AU - Tefera, Lemeneh Y1 - 2016/10/06/ PY - 2016 DA - 2016 Oct 06 SP - 1396 EP - 1397 VL - 375 IS - 14 KW - Analgesics, Opioid KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Adult KW - Disabled Persons KW - Analgesics, Opioid -- therapeutic use KW - Opioid-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835356303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Effect+of+interferents+on+the+performance+of+direct-reading+organic+vapor+monitors&rft.au=LeBouf%2C+Ryan+F%3BCoffey%2C+Christopher+C&rft.aulast=LeBouf&rft.aufirst=Ryan&rft.date=2015-03-04&rft.volume=65&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2014.986308 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-25 N1 - Date created - 2016-10-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: N Engl J Med. 2016 Oct 6;375(14 ):1396-1397 [27705247] Comment On: N Engl J Med. 2016 Jul 7;375(1):44-53 [27332619] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Occupational exposures to new dry cleaning solvents: High-flashpoint hydrocarbons and butylal. AN - 1812888836; 27105306 AB - The dry cleaning industry is moving away from using perchloroethylene. Occupational exposures to two alternative dry cleaning solvents, butylal and high-flashpoint hydrocarbons, have not been well characterized. We evaluated four dry cleaning shops that used these alternative solvents. The shops were staffed by Korean- and Cantonese-speaking owners, and Korean-, Cantonese-, and Spanish-speaking employees. Because most workers had limited English proficiency we used language services in our evaluations. In two shops we collected personal and area air samples for butylal. We also collected air samples for formaldehyde and butanol, potential hydrolysis products of butylal. Because there are no occupational exposure limits for butylal, we assessed employee health risks using control banding tools. In the remaining two shops we collected personal and area air samples for high-flashpoint hydrocarbon solvents. In all shops the highest personal airborne exposures occurred when workers loaded and unloaded the dry cleaning machines and pressed dry cleaned fabrics. The air concentrations of formaldehyde and butanol in the butylal shops were well below occupational exposure limits. Likewise, the air concentrations of high-flashpoint hydrocarbons were also well below occupational exposure limits. However, we saw potential skin exposures to these chemicals. We provided recommendations on appropriate work practices and the selection and use of personal protective equipment. These recommendations were consistent with those derived using control banding tools for butylal. However, there is insufficient toxicological and health information to determine the safety of butylal in occupational settings. Independent evaluation of the toxicological properties of these alternative dry cleaning solvents, especially butylal, is urgently needed. JF - Journal of occupational and environmental hygiene AU - Ceballos, Diana M AU - Whittaker, Stephen G AU - Lee, Eun Gyung AU - Roberts, Jennifer AU - Streicher, Robert AU - Nourian, Fariba AU - Gong, Wei AU - Broadwater, Kendra AD - a Division of Surveillance, Hazard Evaluations, and Field Studies , National Institute for Occupational Safety and Health , Cincinnati , Ohio. ; b Local Hazardous Waste Management Program , Public Health-Seattle & King County , Seattle , Washington. ; c Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia. ; d Division of Applied Research & Technology , National Institute for Occupational Safety and Health , Cincinnati , Ohio. Y1 - 2016/10/02/ PY - 2016 DA - 2016 Oct 02 SP - 759 EP - 769 VL - 13 IS - 10 KW - Index Medicus KW - dibutoxymethane KW - high-flashpoint hydrocarbon KW - Alternative dry cleaning solvents KW - butylal KW - hydrocarbons KW - dry cleaning KW - formaldehyde KW - butanol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812888836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Occupational+exposures+to+new+dry+cleaning+solvents%3A+High-flashpoint+hydrocarbons+and+butylal.&rft.au=Ceballos%2C+Diana+M%3BWhittaker%2C+Stephen+G%3BLee%2C+Eun+Gyung%3BRoberts%2C+Jennifer%3BStreicher%2C+Robert%3BNourian%2C+Fariba%3BGong%2C+Wei%3BBroadwater%2C+Kendra&rft.aulast=Ceballos&rft.aufirst=Diana&rft.date=2016-10-02&rft.volume=13&rft.issue=10&rft.spage=759&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2016.1177648 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2016.1177648 ER - TY - JOUR T1 - Use of auxiliary covariates in estimating a biomarker-adjusted treatment effect model with clinical trial data AN - 1830484150 AB - A biomarker-adjusted treatment effect (BATE) model describes the effect of one treatment versus another on a subpopulation of patients defined by a biomarker. Such a model can be estimated from clinical trial data without relying on additional modeling assumptions, and the estimator can be made more efficient by incorporating information on the main effect of the biomarker on the outcome of interest. Motivated by an HIV trial known as THRIVE, we consider the use of auxiliary covariates, which are usually available in clinical trials and have been used in overall treatment comparisons, in estimating a BATE model. Such covariates can be incorporated using an existing augmentation technique. For a specific type of estimating functions for difference-based BATE models, the optimal augmentation depends only on the joint main effects of marker and covariates. For a ratio-based BATE model, this result holds in special cases but not in general; however, simulation results suggest that the augmentation based on the joint main effects of marker and covariates is virtually equivalent to the theoretically optimal augmentation, especially when the augmentation terms are estimated from data. Application of these methods and results to the THRIVE data yields new insights on the utility of baseline CD4 cell count and viral load as predictive or treatment selection markers. JF - Statistical Methods in Medical Research AU - Zhang, Zhiwei AU - Qu, Yanping AU - Zhang, Bo AU - Nie, Lei AU - Soon, Guoxing AD - Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA ; Biostatistics Core, School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA ; Division of Biometrics IV, Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA ; Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 2103 EP - 2119 CY - London PB - Sage Publications Ltd. VL - 25 IS - 5 SN - 0962-2802 KW - Medical Sciences KW - conditional effect KW - interaction KW - personalized medicine KW - predictive biomarker KW - treatment effect heterogeneity KW - treatment selection KW - Biomarkers KW - Clinical trials KW - Augmentation KW - Immune response system KW - HIV KW - Simulation KW - Clinical research KW - Biological markers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1830484150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Use+of+auxiliary+covariates+in+estimating+a+biomarker-adjusted+treatment+effect+model+with+clinical+trial+data&rft.au=Zhang%2C+Zhiwei%3BQu%2C+Yanping%3BZhang%2C+Bo%3BNie%2C+Lei%3BSoon%2C+Guoxing&rft.aulast=Zhang&rft.aufirst=Zhiwei&rft.date=2016-10-01&rft.volume=25&rft.issue=5&rft.spage=2103&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213515572 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2013 N1 - Last updated - 2016-10-20 DO - http://dx.doi.org/10.1177/0962280213515572 ER - TY - JOUR T1 - New technology in electrophysiology: FDA process and perspective AN - 1827923894; PQ0003723213 AB - The Food and Drug Administration (FDA) is a large regulatory agency that monitors everything from food, tobacco, and veterinary medicine to pharmaceutical drugs and medical devices. The Mission statement of the CDRH, one of the Centers of the FDA, in its most succinct form is to protect and promote public health. This is accomplished through timely and continued access to safe, effective, and high quality medical devices. This paper aims to review the overarching principles of the Agency's review process for cardiac devices as well as highlight some of the newer programs that FDA has engaged in to facilitate innovation, device development, research, and timely market approval. JF - Journal of Interventional Cardiac Electrophysiology AU - Selzman, Kimberly A AU - Fellman, Mark AU - Farb, Andrew AU - de del Castillo, Sergio AU - Zuckerman, Bram AD - Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, Implantable Electrophysiological Devices Branch, WO66, Silver Spring, MD, 20993, USA, kimberly.selzman@fda.hhs.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 11 EP - 18 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 47 IS - 1 SN - 1383-875X, 1383-875X KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Veterinary medicine KW - Reviews KW - Tobacco KW - Pharmaceuticals KW - Electrophysiology KW - Public health KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827923894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interventional+Cardiac+Electrophysiology&rft.atitle=New+technology+in+electrophysiology%3A+FDA+process+and+perspective&rft.au=Selzman%2C+Kimberly+A%3BFellman%2C+Mark%3BFarb%2C+Andrew%3Bde+del+Castillo%2C+Sergio%3BZuckerman%2C+Bram&rft.aulast=Selzman&rft.aufirst=Kimberly&rft.date=2016-10-01&rft.volume=47&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interventional+Cardiac+Electrophysiology&rft.issn=1383875X&rft_id=info:doi/10.1007%2Fs10840-016-0127-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Heart; Veterinary medicine; Reviews; Tobacco; Pharmaceuticals; Electrophysiology; Public health DO - http://dx.doi.org/10.1007/s10840-016-0127-4 ER - TY - JOUR T1 - Suicide Mortality Among Retired National Football League Players Who Played 5 or More Seasons AN - 1827909956; PQ0003722538 AB - Background: There is current disagreement in the scientific literature about the relationship between playing football and suicide risk, particularly among professional players in the National Football League (NFL). While some research indicates players are at high risk of football-related concussions, which may lead to chronic traumatic encephalopathy and suicide, other research finds such a connection to be speculative and unsupported by methodologically sound research. Purpose: To compare the suicide mortality of a cohort of NFL players to what would be expected in the general population of the United States. Study Design: Cohort study; Level of evidence, 3. Methods: A cohort of 3439 NFL players with at least 5 credited playing seasons between 1959 and 1988 was assembled for statistical analysis. The vital status for this cohort was updated through 2013. Standardized mortality ratios (SMRs), the ratio of observed deaths to expected deaths, and 95% CIs were computed for the cohort; 95% CIs that excluded unity were considered statistically significant. For internal comparison purposes, standardized rate ratios were calculated to compare mortality results between players stratified into speed and nonspeed position types. Results: Suicide among this cohort of professional football players was significantly less than would be expected in comparison with the United States population (SMR = 0.47; 95% CI, 0.24-0.82). There were no significant differences in suicide mortality between speed and nonspeed position players. Conclusion: There is no indication of elevated suicide risk in this cohort of professional football players with 5 or more credited seasons of play. Because of the unique nature of this cohort, these study results may not be applicable to professional football players who played fewer than 5 years or to college or high school players. JF - American Journal of Sports Medicine AU - Lehman, Everett J AU - Hein, Misty J AU - Gersic, Christine M AD - .National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA, DYT1@cdc.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 2486 EP - 2491 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 44 IS - 10 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - suicide KW - football KW - National Football League KW - concussion KW - Football (American KW - Athletes (professional) KW - Death KW - Research (statistical design) KW - Associations KW - Suicide KW - Football (American) KW - Professional sports KW - players) KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827909956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Drug+Interactions%3A+An+Evolution+in+Drug+Development&rft.au=Huang%2C+Shiew-Mei&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2016-10-01 N1 - Number of references - 36 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Athletes (professional); Football (American; Death; Research (statistical design); Associations; Football (American); Suicide; Professional sports; players) DO - http://dx.doi.org/10.1177/0363546516645093 ER - TY - JOUR T1 - Nontargeted, Rapid Screening of Extra Virgin Olive Oil Products for Authenticity Using Near-Infrared Spectroscopy in Combination with Conformity Index and Multivariate Statistical Analyses AN - 1827907365; PQ0003726249 AB - A rapid tool for evaluating authenticity was developed and applied to the screening of extra virgin olive oil (EVOO) retail products by using Fourier-transform near infrared (FT-NIR) spectroscopy in combination with univariate and multivariate data analysis methods. Using disposable glass tubes, spectra for 62 reference EVOO, 10 edible oil adulterants, 20 blends consisting of EVOO spiked with adulterants, 88 retail EVOO products and other test samples were rapidly measured in the transmission mode without any sample preparation. The univariate conformity index (CI) and the multivariate supervised soft independent modeling of class analogy (SIMCA) classification tool were used to analyze the various olive oil products which were tested for authenticity against a library of reference EVOO. Better discrimination between the authentic EVOO and some commercial EVOO products was observed with SIMCA than with CI analysis. Approximately 61% of all EVOO commercial products were flagged by SIMCA analysis, suggesting that further analysis be performed to identify quality issues and/or potential adulterants. Due to its simplicity and speed, FT-NIR spectroscopy in combination with multivariate data analysis can be used as a complementary tool to conventional official methods of analysis to rapidly flag EVOO products that may not belong to the class of authentic EVOO. JF - Journal of Food Science AU - Karunathilaka, Sanjeewa R AU - Kia, Ali-Reza Fardin AU - Srigley, Cynthia AU - Chung, Jin Kyu AU - Mossoba, Magdi M AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Md, U.S.A. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - C2390 EP - C2397 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 81 IS - 10 SN - 0022-1147, 0022-1147 KW - Toxicology Abstracts; Environment Abstracts KW - I.R. radiation KW - Classification KW - I.R. spectroscopy KW - Statistical analysis KW - Fats and oils KW - Olive oil KW - Spectroscopy KW - Authenticity KW - X 24320:Food Additives & Contaminants KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827907365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Nontargeted%2C+Rapid+Screening+of+Extra+Virgin+Olive+Oil+Products+for+Authenticity+Using+Near-Infrared+Spectroscopy+in+Combination+with+Conformity+Index+and+Multivariate+Statistical+Analyses&rft.au=Sinha%2C+Vikram&rft.aulast=Sinha&rft.aufirst=Vikram&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - I.R. radiation; Classification; I.R. spectroscopy; Statistical analysis; Spectroscopy; Olive oil; Fats and oils; Authenticity DO - http://dx.doi.org/10.1111/1750-3841.13432 ER - TY - JOUR T1 - Outbreak Investigation of NADC30-Like PRRSV in South-East China AN - 1827907271; PQ0003650111 AB - Epidemiological outbreak investigations were conducted on NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) to investigate the prevalence of the disease in south-east China in 2015. Two more provinces were found to have NADC30-like PRRSV circulating besides previously reported six provinces. Phylogenetic analysis showed that these virus isolates were clustered in an independent branch and shared high nucleotide similarity to NADC30, a type 2 PRRSV that has been isolated in Unite States in 2008. One NADC30-like PRRSV strain from Henan province was successfully isolated on porcine alveolar macrophages and was tested on 6-week-old specific pathogen-free pigs for pathogenic study. The virus-inoculated pigs showed typical PRRSV clinical symptoms, but all pigs survived throughout the study with a period of 14 days. At necropsy, the lungs of infected pigs developed PRRSV-specific interstitial pneumonia, and virus antigen was detected in lung samples. Therefore, our results indicated NADC30-like PRRSV has widely spread in China and could cause clinical disease on pigs. JF - Transboundary and Emerging Diseases AU - Li, C AU - Zhuang, J AU - Wang, J AU - Han, L AU - Sun, Z AU - Xiao, Y AU - Ji, G AU - Li, Y AU - Tan, F AU - Li, X AU - Tian, K AD - National Research Center for Veterinary Medicine, Luoyang, China. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 474 EP - 479 PB - Wiley-Blackwell Verlag GmbH VL - 63 IS - 5 SN - 1865-1674, 1865-1674 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Phylogeny KW - Macrophages KW - Porcine respiratory and reproductive syndrome virus KW - Autopsy KW - Lung KW - Pneumonia KW - Alveoli KW - Nucleotides KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827907271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transboundary+and+Emerging+Diseases&rft.atitle=Outbreak+Investigation+of+NADC30-Like+PRRSV+in+South-East+China&rft.au=Li%2C+C%3BZhuang%2C+J%3BWang%2C+J%3BHan%2C+L%3BSun%2C+Z%3BXiao%2C+Y%3BJi%2C+G%3BLi%2C+Y%3BTan%2C+F%3BLi%2C+X%3BTian%2C+K&rft.aulast=Li&rft.aufirst=C&rft.date=2016-10-01&rft.volume=63&rft.issue=5&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Transboundary+and+Emerging+Diseases&rft.issn=18651674&rft_id=info:doi/10.1111%2Ftbed.12530 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Macrophages; Phylogeny; Autopsy; Lung; Nucleotides; Alveoli; Pneumonia; Porcine respiratory and reproductive syndrome virus DO - http://dx.doi.org/10.1111/tbed.12530 ER - TY - JOUR T1 - Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes AN - 1827894971; PQ0003725500 AB - Background: The Mediterranean diet has been consistently associated with reduced mortality risk. Few prospective studies have examined whether the benefits from a Mediterranean diet are equally shared by obese individuals with varying metabolic health. Objective: The objective of this study was to investigate the association between Mediterranean diet, metabolic phenotypes and mortality risk in a representative obese US population. Methods: Data from 1739 adults aged 20-88 years were analyzed from participants of the National Health and Nutrition Examination Survey III, 1988-1994 followed up for deaths until 31 December 2011 in a prospective cohort analysis. Mediterranean Diet Scores (MDS) were created to assess the adherence to Mediterranean diet. Participants were classified as metabolically healthy obese (MHO) phenotype (0 or 1 metabolic abnormality) or metabolically unhealthy obese (MUO) phenotype (two or more metabolic abnormalities), based on high glucose, insulin resistance, blood pressure, triglycerides, C-reactive protein and low high-density lipoprotein cholesterol. Results: The MHO phenotype (n=598) was observed in 34.8% (s.e., 1.7%) of those who were obese (mean body mass index was 33.4 and 34.8 in MHO and MUO phenotypes, respectively). During a median follow-up of 18.5 years, there were 77 (12.9%) and 309 (27.1%) deaths in MHO and MUO individuals, respectively. In MHO individuals, the multivariable-adjusted hazard ratio (HR) of all-cause mortality in the highest tertile compared with the first tertile of MDS was 0.44 (95% confidence interval (CI), 0.26-0.75; P for trend <0.001), after adjustment for potential confounders. A five-point (1 s.d.) increment in the adherence to MDS was associated with a 41% reduction in the risk of all-cause mortality (HR, 0.59; 95% CI, 0.37-0.94). Similar findings were obtained when we restricted our analyses to those with or without prevalent diabetes mellitus and hypertension. We did not observe mortality risk reduction in either individuals with MUO phenotype or all obese participants combined. Conclusions: Adherence to a Mediterranean dietary pattern appears to reduce mortality in the MHO phenotype, but not among the MUO phenotype in an obese population. JF - International Journal of Obesity AU - Park, Y-M AU - Steck, S E AU - Fung, T T AU - Zhang, J AU - Hazlett, L J AU - Han, K AU - Merchant, A T AD - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1541 EP - 1549 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 40 IS - 10 SN - 0307-0565, 0307-0565 KW - Physical Education Index; Health & Safety Science Abstracts KW - Risk assessment KW - Death KW - Body mass KW - Lipids KW - Compliance KW - Glucose KW - Health KW - Risk reduction KW - Adults KW - Nutrition KW - Blood pressure KW - Insulin KW - Diets KW - Mortality KW - Obesity KW - Cholesterol KW - Diabetes mellitus KW - MED KW - Analysis KW - Proteins KW - Diet KW - Hypertension KW - H 12000:Epidemiology and Public Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827894971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Mediterranean+diet+and+mortality+risk+in+metabolically+healthy+obese+and+metabolically+unhealthy+obese+phenotypes&rft.au=Park%2C+Y-M%3BSteck%2C+S+E%3BFung%2C+T+T%3BZhang%2C+J%3BHazlett%2C+L+J%3BHan%2C+K%3BMerchant%2C+A+T&rft.aulast=Park&rft.aufirst=Y-M&rft.date=2016-10-01&rft.volume=40&rft.issue=10&rft.spage=1541&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fijo.2016.114 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Obesity; Death; Lipids; Analysis; Compliance; Health; Adults; Diet; Nutrition; Diets; Risk assessment; Mortality; Body mass; Glucose; Risk reduction; Cholesterol; Insulin; Blood pressure; Diabetes mellitus; Proteins; Hypertension; MED DO - http://dx.doi.org/10.1038/ijo.2016.114 ER - TY - GEN T1 - Corrigendum to 'The Janus faces of 3-hydroxykynurenine: Dual redox modulatory activity and lack of neurotoxicity in the rat striatum' [Brain Res. 1589 (2014) 1-14]. AN - 1826729398; 27450192 JF - Brain research AU - Colín-González, Ana Laura AU - Maya-López, Marisol AU - Pedraza-Chaverrí, José AU - Ali, Syed F AU - Chavarría, Anahí AU - Santamaría, Abel Y1 - 2016/10/01/ PY - 2016 DA - 2016 Oct 01 SP - 525 VL - 1648 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826729398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Brain+research&rft.atitle=Corrigendum+to+%27The+Janus+faces+of+3-hydroxykynurenine%3A+Dual+redox+modulatory+activity+and+lack+of+neurotoxicity+in+the+rat+striatum%27+%5BBrain+Res.+1589+%282014%29+1-14%5D.&rft.au=Col%C3%ADn-Gonz%C3%A1lez%2C+Ana+Laura%3BMaya-L%C3%B3pez%2C+Marisol%3BPedraza-Chaverr%C3%AD%2C+Jos%C3%A9%3BAli%2C+Syed+F%3BChavarr%C3%ADa%2C+Anah%C3%AD%3BSantamar%C3%ADa%2C+Abel&rft.aulast=Col%C3%ADn-Gonz%C3%A1lez&rft.aufirst=Ana&rft.date=2016-10-01&rft.volume=1648&rft.issue=&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2016.07.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.brainres.2016.07.004 ER - TY - JOUR T1 - Trastuzumab-Related Cardiotoxic Effects in Taiwanese Women: A Nationwide Cohort Study. AN - 1826701949; 27310478 AB - Importance Trastuzumab is an essential medicine per the World Health Organization Model List, but its cardiac safety information in Asian women is limited. Objective To estimate the rate and the risk of heart failure (HF) and/or cardiomyopathy (CM) in Asian women undergoing trastuzumab treatment. Design This cohort study used the Taiwanese National Health Insurance Research Database (NHIRD), a nationwide claim database covering more than 99% of the entire Taiwanese population, to identify 23 006 women with incident breast cancer (BC) who received chemotherapy from 2006 to 2009. We grouped women per their initial treatment regimens and found 1066 new trastuzumab users. We matched trastuzumab users with nonusers by year of BC diagnosis and propensity score (PS) with the caliper widths at 0.25 standard deviation of PS (up to 4 nonusers per trastuzumab user). The study lasted from January 2006 to December 2013 with a median follow-up of 5.29 years and a landmark design to avoid immortal time bias. Exposure Trastuzumab. Main Outcomes and Measures To estimate HF and/or CM rates and time to HF and/or CM, we employed a cause-specific hazard model. Trastuzumab exposure was a time-dependent variable, while cumulative courses of chemotherapy agents with known cardiotoxic effects (including anthracyclines, taxanes, and cyclophosphamide) were defined as time-dependent covariates in the analysis model. We also performed 6 sensitivity analyses. Results In this cohort of 23 006 women (mean age, 50.99 years), the crude incidence of HF and/or CM was 4.03% in trastuzumab users and 2.88% in nonusers. The median time to HF and/or CM was 456 days in trastuzumab users and 966 days in nonusers. The 1-year cumulative hazard ratio was 1.86 (95% CI, 1.08-3.19). The sensitivity analyses yielded similar results. Conclusions and Relevance Compared with the published results, the trastuzumab-related HF and/or CM rate was 5-fold lower in Taiwanese women with breast cancer. Nonetheless, our cohort had a similar trastuzumab-related HF and/or CM risk. Our study provides critical cardiac safety information of trastuzumab for Asian women with BC under current treatment guidelines and label information. JF - JAMA oncology AU - Chien, Hsu-Chih AU - Kao Yang, Yea-Huei AU - Bai, Jane P F AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland2Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan3Health Outcome Research Center, National Cheng Kung University, Tainan, Taiwan. ; Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan3Health Outcome Research Center, National Cheng Kung University, Tainan, Taiwan. ; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland. Y1 - 2016/10/01/ PY - 2016 DA - 2016 Oct 01 SP - 1317 EP - 1325 VL - 2 IS - 10 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826701949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA+oncology&rft.atitle=Trastuzumab-Related+Cardiotoxic+Effects+in+Taiwanese+Women%3A+A+Nationwide+Cohort+Study.&rft.au=Chien%2C+Hsu-Chih%3BKao+Yang%2C+Yea-Huei%3BBai%2C+Jane+P+F&rft.aulast=Chien&rft.aufirst=Hsu-Chih&rft.date=2016-10-01&rft.volume=2&rft.issue=10&rft.spage=1317&rft.isbn=&rft.btitle=&rft.title=JAMA+oncology&rft.issn=2374-2445&rft_id=info:doi/10.1001%2Fjamaoncol.2016.1269 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-16 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1001/jamaoncol.2016.1269 ER - TY - JOUR T1 - Opportunities for social work under the Affordable Care Act: A call for action AN - 1825970871 AB - The Affordable Care Act (ACA) has profoundly restructured American health care. Numerous social work authors have commented on the importance of the ACA's reforms to social work practice, education, and research. This article summarizes the literature, adds relevant information, and makes recommendations for future actions. The policy, opinion, and peer-reviewed literatures were systematically reviewed. Sixty-three publications appeared between 2010 and 2015 are included. Five themes emerged, as follows: 1) the crucial provisions of the ACA, 2) the natural affinity of social work and the ACA reforms, 3) curricular adaptations needed to address changing workforce needs, 4) areas for continued social work advocacy, and 5) opportunities for high-impact social work research. This article provides a comprehensive introduction to the ACA, its reforms, and opportunities for social work to assume a high visibility leadership role in implementing the reforms, with particular emphasis on needed curricular changes and opportunities for research. JF - Social Work in Health Care AU - Lynch, Sean, PhD AU - Greeno, Catherine, PhD AU - Teich, Judith, PhD AU - Delany, Peter, PhD AD - Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA ; School of Social Work, University of Pittsburgh, Pittsburgh, Pennsylvania, USA ; Office of National Drug Control Policy, Washington, District of Columbia, USA ; Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 651 EP - 674 CY - New York PB - Taylor & Francis Ltd. VL - 55 IS - 9 SN - 0098-1389 KW - Social Services And Welfare KW - Affordable Care Act KW - health care reform KW - integrated care KW - policy KW - social work KW - social work practice KW - Health care policy KW - Patient Protection & Affordable Care Act 2010-US KW - Social work KW - Leadership KW - Health Care Services KW - Social Work Education KW - Social Work Research KW - Health Care Services Policy KW - Health care KW - Labour force KW - Professional practices KW - Publications KW - Professional training KW - Occupational health and safety KW - Advocacy KW - Reforms KW - Severely KW - Affinity KW - Visibility KW - 6140:illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825970871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Opportunities+for+social+work+under+the+Affordable+Care+Act%3A+A+call+for+action&rft.au=Lynch%2C+Sean%2C+PhD%3BGreeno%2C+Catherine%2C+PhD%3BTeich%2C+Judith%2C+PhD%3BDelany%2C+Peter%2C+PhD&rft.aulast=Lynch&rft.aufirst=Sean&rft.date=2016-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Social Services Abstracts N1 - Copyright - This article is not subject to U.S. copyright law. N1 - Last updated - 2017-01-06 DO - http://dx.doi.org/10.1080/00981389.2016.1221871 ER - TY - JOUR T1 - Causal inference with missing exposure information: Methods and applications to an obstetric study AN - 1825333867 AB - Causal inference in observational studies is frequently challenged by the occurrence of missing data, in addition to confounding. Motivated by the Consortium on Safe Labor, a large observational study of obstetric labor practice and birth outcomes, this article focuses on the problem of missing exposure information in a causal analysis of observational data. This problem can be approached from different angles (i.e. missing covariates and causal inference), and useful methods can be obtained by drawing upon the available techniques and insights in both areas. In this article, we describe and compare a collection of methods based on different modeling assumptions, under standard assumptions for missing data (i.e. missing-at-random and positivity) and for causal inference with complete data (i.e. no unmeasured confounding and another positivity assumption). These methods involve three models: one for treatment assignment, one for the dependence of outcome on treatment and covariates, and one for the missing data mechanism. In general, consistent estimation of causal quantities requires correct specification of at least two of the three models, although there may be some flexibility as to which two models need to be correct. Such flexibility is afforded by doubly robust estimators adapted from the missing covariates literature and the literature on causal inference with complete data, and by a newly developed triply robust estimator that is consistent if any two of the three models are correct. The methods are applied to the Consortium on Safe Labor data and compared in a simulation study mimicking the Consortium on Safe Labor. JF - Statistical Methods in Medical Research AU - Zhang, Zhiwei AU - Liu, Wei AU - Zhang, Bo AU - Tang, Li AU - Zhang, Jun AD - Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA ; Department of Mathematics, Harbin Institute of Technology, Harbin, P.R. China ; Biostatistics Core, School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA ; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA ; MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China ; Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 2053 EP - 2066 CY - London PB - Sage Publications Ltd. VL - 25 IS - 5 SN - 0962-2802 KW - Medical Sciences KW - counterfactual KW - double robustness KW - inverse probability weighting KW - missing at random KW - missing covariate KW - propensity score KW - triple robustness KW - Obstetrics KW - Consortia KW - Regression analysis KW - Missing data KW - Observational research KW - Simulation KW - Specification KW - Flexibility KW - Positive affect KW - Childbirth KW - Estimators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825333867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Causal+inference+with+missing+exposure+information%3A+Methods+and+applications+to+an+obstetric+study&rft.au=Zhang%2C+Zhiwei%3BLiu%2C+Wei%3BZhang%2C+Bo%3BTang%2C+Li%3BZhang%2C+Jun&rft.aulast=Zhang&rft.aufirst=Zhiwei&rft.date=2016-10-01&rft.volume=25&rft.issue=5&rft.spage=2053&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213513758 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2013 N1 - Last updated - 2016-10-04 DO - http://dx.doi.org/10.1177/0962280213513758 ER - TY - JOUR T1 - Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure. AN - 1825217970; 27473664 AB - Personal exposure to fungal bioaerosols derived from contaminated building materials or agricultural commodities may induce or exacerbate a variety of adverse health effects. The genomic mechanisms that underlie pulmonary immune responses to fungal bioaerosols have remained unclear. The impact of fungal viability on the pulmonary microRNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia. Three groups of naïve B6C3F1/N mice were exposed via nose-only inhalation to A. fumigatus viable conidia, heat-inactivated conidia (HIC), or HEPA-filtered air twice a week for 13 weeks. Total RNA was isolated from whole lung 24 and 48 h postfinal exposure and was further processed for gene expression and microRNA array analysis. The molecular network pathways between viable and HIC groups were evaluated. Comparison of data sets revealed increased Il4, Il13 and Il33 expression in mice exposed to viable vs. HIC. Of 415 microRNAs detected, approximately 50% were altered in mice exposed to viable vs. HIC 48 h postexposure. Significantly down-regulated (P ≤ 0.05) miR-29a-3p was predicted to regulate TGF-β3 and Clec7a, genes involved in innate responses to viable A. fumigatus. Also significantly down-regulated (P ≤ 0.05), miR-23b-3p regulates genes involved in pulmonary IL-13 and IL-33 responses and SMAD2, downstream of TGF-β signalling. Using Ingenuity Pathway Analysis, a novel interaction was identified between viable conidia and SMAD2/3. Examination of the pulmonary genetic profiles revealed differentially expressed genes and microRNAs following subchronic inhalation exposure to A. fumigatus. MicroRNAs regulating genes involved in the pulmonary immune responses were those with the greatest fold change. Specifically, germinating A. fumigatus conidia were associated with Clec7a and were predicted to interact with Il13 and Il33. Furthermore, altered microRNAs may serve as potential biomarkers to evaluate fungal exposure. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology AU - Croston, T L AU - Nayak, A P AU - Lemons, A R AU - Goldsmith, W T AU - Gu, J K AU - Germolec, D R AU - Beezhold, D H AU - Green, B J AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. xzu9@cdc.gov. ; Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. ; Engineering and Control Technology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. ; Toxicology Branch, DNTP/NIEHS, Research Triangle Park, NC, USA. ; Office of the Director, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1315 EP - 1327 VL - 46 IS - 10 KW - Index Medicus KW - genetics KW - allergens and epitopes KW - animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825217970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+allergy+%3A+journal+of+the+British+Society+for+Allergy+and+Clinical+Immunology&rft.atitle=Influence+of+Aspergillus+fumigatus+conidia+viability+on+murine+pulmonary+microRNA+and+mRNA+expression+following+subchronic+inhalation+exposure.&rft.au=Croston%2C+T+L%3BNayak%2C+A+P%3BLemons%2C+A+R%3BGoldsmith%2C+W+T%3BGu%2C+J+K%3BGermolec%2C+D+R%3BBeezhold%2C+D+H%3BGreen%2C+B+J&rft.aulast=Croston&rft.aufirst=T&rft.date=2016-10-01&rft.volume=46&rft.issue=10&rft.spage=1315&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+allergy+%3A+journal+of+the+British+Society+for+Allergy+and+Clinical+Immunology&rft.issn=1365-2222&rft_id=info:doi/10.1111%2Fcea.12783 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/cea.12783 ER - TY - JOUR T1 - Potential Reuse of Oncology Drugs in the Treatment of Rare Diseases. AN - 1822117442; 27461952 AB - Cancer research has made remarkable progress with the help of advancing genomics techniques, resulting in more precise clinical application and many new anticancer drugs on the market. By contrast, very few treatment options are available for rare diseases that are often progressive, severe, and life-threatening. In this opinion we elaborate on the possible association between cancers and rare diseases across three different levels including clinical observation, crosstalk between germline mutation and somatic mutation, and shared biological pathways. Consequently, by utilizing systematic drug-repositioning approaches, and taking safety issues into consideration, we suggest that oncology drugs have great potential for reuse in the treatment of rare diseases. Published by Elsevier Ltd. JF - Trends in pharmacological sciences AU - Liu, Zhichao AU - Fang, Hong AU - Slikker, William AU - Tong, Weida AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Zhichao.liu@fda.hhs.gov. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: weida.tong@fda.hhs.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 843 EP - 857 VL - 37 IS - 10 KW - Index Medicus KW - genetic mutations KW - rare disease KW - oncology drugs KW - cancer KW - drug repositioning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1822117442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+pharmacological+sciences&rft.atitle=Potential+Reuse+of+Oncology+Drugs+in+the+Treatment+of+Rare+Diseases.&rft.au=Liu%2C+Zhichao%3BFang%2C+Hong%3BSlikker%2C+William%3BTong%2C+Weida&rft.aulast=Liu&rft.aufirst=Zhichao&rft.date=2016-10-01&rft.volume=37&rft.issue=10&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Trends+in+pharmacological+sciences&rft.issn=1873-3735&rft_id=info:doi/10.1016%2Fj.tips.2016.06.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tips.2016.06.010 ER - TY - JOUR T1 - Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients. AN - 1820594105; 27259059 AB - Sirolimus, an immunosuppressive agent used in renal transplantation, can prevent allograft rejection. Identification of the therapeutic index (the ratio of minimum toxic concentration to minimum therapeutic concentration) for immunosuppresants is necessary to optimize the care of patients and set standards for bioequivalence evaluation of sirolimus products. However, the therapeutic index for sirolimus has been inconsistently defined, potentially because of inconsistencies in sirolimus exposure-response relationships. The authors used retrospective therapeutic drug monitoring data from the electronic health records of patients treated in a tertiary health care system from 2008 to 2014 to (1) develop a population pharmacokinetic (PK) model, (2) use the model to simulate sirolimus concentrations, and (3) characterize the exposure-response relationship. Using Wilcoxon rank-sum and Fisher exact tests, the authors determined relationships between sirolimus exposure and adverse events (AEs) (anemia, leukopenia, thrombocytopenia, hyperlipidemia, and decline in renal function) and the composite efficacy end point of graft loss or rejection. The developed 2-compartment population PK model showed appropriate goodness of fit. In a late-phase (>12 months), postrenal transplant population of 27 inpatients, the authors identified statistically significant relationships between 83 simulated peak and trough sirolimus concentrations and outcomes: graft loss or rejection (P = 0.018) and decline in renal function (P = 0.006), respectively. Use of therapeutic drug monitoring results and PK modeling permitted correlation of sirolimus concentrations with graft loss or rejection and decline in renal function. However, the method was limited in its assessment of other AEs. To better evaluate sirolimus exposure-response relationships, the method should be applied to a larger sample of newly transplanted patients with a higher propensity toward AEs or efficacy failure. JF - Therapeutic drug monitoring AU - Zimmerman, Kanecia O AU - Wu, Huali AU - Greenberg, Rachel AU - Guptill, Jeffrey T AU - Hill, Kevin AU - Patel, Uptal D AU - Ku, Lawrence AU - Gonzalez, Daniel AU - Hornik, Christoph AU - Jiang, Wenlei AU - Zheng, Nan AU - Melloni, Chiara AU - Cohen-Wolkowiez, Michael AD - *Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina; Departments of †Pediatrics and ‡Medicine, Duke University School of Medicine, Durham, North Carolina; §Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina; and ¶Office of Generic Drugs, US Food and Drug Administration, Silver Spring, Maryland. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 600 EP - 606 VL - 38 IS - 5 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1820594105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+drug+monitoring&rft.atitle=Therapeutic+Drug+Monitoring%2C+Electronic+Health+Records%2C+and+Pharmacokinetic+Modeling+to+Evaluate+Sirolimus+Drug+Exposure-Response+Relationships+in+Renal+Transplant+Patients.&rft.au=Zimmerman%2C+Kanecia+O%3BWu%2C+Huali%3BGreenberg%2C+Rachel%3BGuptill%2C+Jeffrey+T%3BHill%2C+Kevin%3BPatel%2C+Uptal+D%3BKu%2C+Lawrence%3BGonzalez%2C+Daniel%3BHornik%2C+Christoph%3BJiang%2C+Wenlei%3BZheng%2C+Nan%3BMelloni%2C+Chiara%3BCohen-Wolkowiez%2C+Michael&rft.aulast=Zimmerman&rft.aufirst=Kanecia&rft.date=2016-10-01&rft.volume=38&rft.issue=5&rft.spage=600&rft.isbn=&rft.btitle=&rft.title=Therapeutic+drug+monitoring&rft.issn=1536-3694&rft_id=info:doi/10.1097%2FFTD.0000000000000313 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/FTD.0000000000000313 ER - TY - JOUR T1 - Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery. AN - 1819905458; 27195510 AB - Androgen receptor (AR) is a ligand-dependent transcription factor and a member of the nuclear receptor superfamily. It plays a vital role in male sexual development and regulates gene expression in various tissues, including prostate. Androgens are compounds that exert their biological effects via interaction with AR. Binding of androgens to AR initiates conformational changes in AR that affect binding of co-regulator proteins and DNA. AR agonists and antagonists are widely used in a variety of clinical applications (i.e. hypogonadism and prostate cancer therapy). This review provides a close look at structures of AR-ligand complexes and mutations in the receptor that have been revealed, discusses current challenges in the field, and sheds light on future directions. AR is one of the primary targets for the treatment of prostate cancer, as AR antagonists inhibit prostate cancer growth. However, these drugs are not effective for long-term treatment and lead to castration-resistant prostate cancer. The structures of AR-ligand complexes are an invaluable scientific asset that enhances our understanding of biological functions and mechanisms of androgenic and anti-androgenic chemicals as well as promotes the discovery of superior drug candidates. JF - Expert opinion on therapeutic targets AU - Sakkiah, Sugunadevi AU - Ng, Hui Wen AU - Tong, Weida AU - Hong, Huixiao AD - a Division of Bioinformatics and Biostatistics , National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson , AR , USA. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1267 EP - 1282 VL - 20 IS - 10 KW - Index Medicus KW - Androgen receptor KW - testosterone KW - endocrine disruptors KW - dihydrotestosterone KW - endocrine receptor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819905458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+therapeutic+targets&rft.atitle=Structures+of+androgen+receptor+bound+with+ligands%3A+advancing+understanding+of+biological+functions+and+drug+discovery.&rft.au=Sakkiah%2C+Sugunadevi%3BNg%2C+Hui+Wen%3BTong%2C+Weida%3BHong%2C+Huixiao&rft.aulast=Sakkiah&rft.aufirst=Sugunadevi&rft.date=2016-10-01&rft.volume=20&rft.issue=10&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+therapeutic+targets&rft.issn=1744-7631&rft_id=info:doi/10.1080%2F14728222.2016.1192131 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/14728222.2016.1192131 ER - TY - JOUR T1 - Diagnosis lost: Differences between children who had and who currently have an autism spectrum disorder diagnosis AN - 1817564956 AB - Autism spectrum disorder diagnoses sometimes change due to misdiagnosis, maturation, or treatment. This study uses a probability-based national survey--the Survey of Pathways to Diagnosis and Services--to compare currently diagnosed (n = 1420) and previously diagnosed (n = 187) children aged 6-17 years based on retrospective parental reports of early concerns about their children's development, responses to those concerns by doctors and other healthcare providers, the type of provider who made the first autism spectrum disorder diagnosis, and the autism spectrum disorder subtype diagnoses received (if any). Propensity score matching was used to control for differences between the groups on children's current level of functioning and other current characteristics that may have been related to diagnosis loss. Approximately 13% of the children ever diagnosed with autism spectrum disorder were estimated to have lost the diagnosis, and parents of 74% of them believed it was changed due to new information. Previously diagnosed children were less likely to have parents with early concerns about verbal skills, nonverbal communication, learning, and unusual gestures or movements. They were also less likely to have been referred to and diagnosed by a specialist. Previously diagnosed children were less likely to have ever received a diagnosis of Asperger's disorder or autistic disorder. JF - Autism AU - Blumberg, Stephen J AU - Zablotsky, Benjamin AU - Avila, Rosa M AU - Colpe, Lisa J AU - Pringle, Beverly A AU - Kogan, Michael D AD - Centers for Disease Control and Prevention, USA ; University of Washington, USA ; National Institutes of Health, USA ; Health Resources and Services Administration, USA ; Centers for Disease Control and Prevention, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 783 EP - 795 CY - London PB - SAGE PUBLICATIONS, INC. VL - 20 IS - 7 SN - 1362-3613 KW - Psychology KW - autism spectrum disorder KW - diagnosis KW - epidemiology KW - national surveys KW - Health care KW - Maturation KW - Autistic spectrum disorders KW - Misdiagnosis KW - Autistic children KW - National surveys KW - Doctors KW - Learning KW - Asperger's syndrome KW - Child development KW - Gestures KW - Nonverbal communication KW - Diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1817564956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autism&rft.atitle=Diagnosis+lost%3A+Differences+between+children+who+had+and+who+currently+have+an+autism+spectrum+disorder+diagnosis&rft.au=Blumberg%2C+Stephen+J%3BZablotsky%2C+Benjamin%3BAvila%2C+Rosa+M%3BColpe%2C+Lisa+J%3BPringle%2C+Beverly+A%3BKogan%2C+Michael+D&rft.aulast=Blumberg&rft.aufirst=Stephen&rft.date=2016-10-01&rft.volume=20&rft.issue=7&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Autism&rft.issn=13623613&rft_id=info:doi/10.1177%2F1362361315607724 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2015 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1177/1362361315607724 ER - TY - JOUR T1 - The Short-Term Effect of Depressive Symptoms on Labor Market Outcomes AN - 1816900612 AB - We estimated the short-term effects of symptoms of depression on labor market outcomes using data from the 2004-2009 Medical Expenditure Panel Survey. After accounting for the endogeneity of depression through a correlated random effects panel data specification, we found that exhibiting depressive symptoms reduces the likelihood of employment. We did not, however, find evidence of a causal relationship between depressive symptoms and hourly wages or weekly hours worked. Our estimates are substantially smaller than those from previous studies and imply that depressive symptoms reduce the contemporaneous probability of employment by 2.4 percentage points. In addition, we examined the effect of depression on work impairment and found that exhibiting depressive symptoms increases annual work loss days by about 1.4 days (33%), which implies that the annual aggregate productivity loses because of depression-induced absenteeism range from $900m to $1.9bn in 2009 USD. Copyright © 2015 John Wiley & Sons, Ltd. JF - Health Economics AU - Peng, Lizhong AU - Meyerhoefer, Chad D AU - Zuvekas, Samuel H AD - Health and Social Development Program, American Institutes for Research, Washington, DC, USA ; Department of Economics, Lehigh University, Bethlehem, PA, USA ; Center for Financing, Access and Cost Trends, U.S. Agency for Healthcare Research and Quality, Rockville, MD, USA ; Health and Social Development Program, American Institutes for Research, Washington, DC, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 1223 EP - 1238 CY - York PB - Wiley Subscription Services, Inc. VL - 25 IS - 10 SN - 1057-9230 KW - Business And Economics--Economic Situation And Conditions KW - Productivity KW - Short term KW - Labour market KW - Depression KW - Random effects KW - Labour KW - Specification KW - Absenteeism KW - Panel data KW - Employment KW - Working hours KW - Expenditure KW - Wages KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816900612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=The+Short-Term+Effect+of+Depressive+Symptoms+on+Labor+Market+Outcomes&rft.au=Peng%2C+Lizhong%3BMeyerhoefer%2C+Chad+D%3BZuvekas%2C+Samuel+H&rft.aulast=Peng&rft.aufirst=Lizhong&rft.date=2016-10-01&rft.volume=25&rft.issue=10&rft.spage=1223&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.3224 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © 2016 John Wiley & Sons, Ltd. N1 - Last updated - 2016-09-07 DO - http://dx.doi.org/10.1002/hec.3224 ER - TY - JOUR T1 - Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena. AN - 1816864281; 27480511 AB - The association between exposure to smokeless tobacco products (STP) and oral diseases is partially due to the physiological and pathological changes in the composition of the oral microbiome and its metabolic profile. However, it is not clear how STPs affect the physiology and ecology of oral microbiota. A UPLC/QTof-MS-based metabolomics study was employed to analyze metabolic alterations in oral bacterium, Capnocytophaga sputigena as a result of smokeless tobacco exposure and to assess the capability of the bacterium to metabolize nicotine. Pathway analysis of the metabolome profiles indicated that smokeless tobacco extracts caused oxidative stress in the bacterium. The metabolomics data also showed that the arginine-nitric oxide pathway was perturbed by the smokeless tobacco treatment. Results also showed that LC/MS was useful in identifying STP constituents and additives, including caffeine and many flavoring compounds. No significant changes in levels of nicotine and its major metabolites were found when C. sputigena was cultured in a nutrient rich medium, although hydroxylnicotine and cotinine N-oxide were detected in the bacterial metabolites suggesting that nicotine metabolism might be present as a minor degradation pathway in the bacterium. Study results provide new insights regarding the physiological and toxicological effects of smokeless tobacco on oral bacterium C. sputigena and associated oral health as well as measuring the ability of the oral bacterium to metabolize nicotine. Published by Elsevier Ltd. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Sun, Jinchun AU - Jin, Jinshan AU - Beger, Richard D AU - Cerniglia, Carl E AU - Yang, Maocheng AU - Chen, Huizhong AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd, Jefferson, AR 72079, United States. Electronic address: Jinchun.Sun@fda.hhs.gov. ; Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd, Jefferson, AR 72079, United States. ; Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd, Jefferson, AR 72079, United States. ; Office of Science, Center for Tobacco Products, US FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, United States. Electronic address: Maocheng.Yang@fda.hhs.gov. ; Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd, Jefferson, AR 72079, United States. Electronic address: Huizhong.Chen@fda.hhs.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 133 EP - 141 VL - 36 KW - Index Medicus KW - Smokeless tobacco KW - Oral bacteria KW - Toxicology KW - Metabolomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816864281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Metabolomics+evaluation+of+the+impact+of+smokeless+tobacco+exposure+on+the+oral+bacterium+Capnocytophaga+sputigena.&rft.au=Sun%2C+Jinchun%3BJin%2C+Jinshan%3BBeger%2C+Richard+D%3BCerniglia%2C+Carl+E%3BYang%2C+Maocheng%3BChen%2C+Huizhong&rft.aulast=Sun&rft.aufirst=Jinchun&rft.date=2016-10-01&rft.volume=36&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2016.07.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2016.07.020 ER - TY - JOUR T1 - Regulatory bioinformatics for food and drug safety. AN - 1816638572; 27208439 AB - "Regulatory Bioinformatics" strives to develop and implement a standardized and transparent bioinformatic framework to support the implementation of existing and emerging technologies in regulatory decision-making. It has great potential to improve public health through the development and use of clinically important medical products and tools to manage the safety of the food supply. However, the application of regulatory bioinformatics also poses new challenges and requires new knowledge and skill sets. In the latest Global Coalition on Regulatory Science Research (GCRSR) governed conference, Global Summit on Regulatory Science (GSRS2015), regulatory bioinformatics principles were presented with respect to global trends, initiatives and case studies. The discussion revealed that datasets, analytical tools, skills and expertise are rapidly developing, in many cases via large international collaborative consortia. It also revealed that significant research is still required to realize the potential applications of regulatory bioinformatics. While there is significant excitement in the possibilities offered by precision medicine to enhance treatments of serious and/or complex diseases, there is a clear need for further development of mechanisms to securely store, curate and share data, integrate databases, and standardized quality control and data analysis procedures. A greater understanding of the biological significance of the data is also required to fully exploit vast datasets that are becoming available. The application of bioinformatics in the microbiological risk analysis paradigm is delivering clear benefits both for the investigation of food borne pathogens and for decision making on clinically important treatments. It is recognized that regulatory bioinformatics will have many beneficial applications by ensuring high quality data, validated tools and standardized processes, which will help inform the regulatory science community of the requirements necessary to ensure the safe introduction and effective use of these applications. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Healy, Marion J AU - Tong, Weida AU - Ostroff, Stephen AU - Eichler, Hans-Georg AU - Patak, Alex AU - Neuspiel, Margaret AU - Deluyker, Hubert AU - Slikker, William AD - Food Standards Australia New Zealand, Barton, Australian Capital Territory, 2905, Australia. Electronic address: marion.healy@foodstandards.gov.au. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079-9502, USA. Electronic address: weida.tong@fda.hhs.gov. ; US Food and Drug Administration, Silver Spring, MD, 20993-0002, USA. Electronic address: stephen.ostroff@fda.hhs.gov. ; European Medicines Agency, London, E14 5EU, United Kingdom. Electronic address: hans-georg.eichler@ema.europa.eu. ; European Commission, Joint Research Centre, Ispra, Varese, 21027, Italy. Electronic address: alex.patak@ec.europa.eu. ; Canadian Food Inspection Agency, Ottawa, Ontario, Canada. Electronic address: margaret.neuspiel@inspection.gc.ca. ; European Food Safety Authority, Parma, 43126, Italy. Electronic address: Hubert.deluyker@efsa.europa.eu. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079-9502, USA. Electronic address: william.slikker@fda.hhs.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 342 EP - 347 VL - 80 KW - Index Medicus KW - Regulatory science KW - GSRS KW - Microbiome KW - GCRSR KW - Food safety KW - Regulatory bioinformatics KW - Bioinformatics KW - Next-generation sequencing KW - Genomics KW - Drug safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816638572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Regulatory+bioinformatics+for+food+and+drug+safety.&rft.au=Healy%2C+Marion+J%3BTong%2C+Weida%3BOstroff%2C+Stephen%3BEichler%2C+Hans-Georg%3BPatak%2C+Alex%3BNeuspiel%2C+Margaret%3BDeluyker%2C+Hubert%3BSlikker%2C+William&rft.aulast=Healy&rft.aufirst=Marion&rft.date=2016-10-01&rft.volume=80&rft.issue=&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.05.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.05.021 ER - TY - JOUR T1 - A biokinetic model for nickel released from cardiovascular devices. AN - 1816637708; 27208438 AB - Many alloys used in cardiovascular device applications contain high levels of nickel, which if released in sufficient quantities, can lead to adverse health effects. While nickel release from these devices is typically characterized through the use of in-vitro immersion tests, it is unclear if the rate at which nickel is released from a device during in-vitro testing is representative of the release rate following implantation in the body. To address this uncertainty, we have developed a novel biokinetic model that combines a traditional toxicokinetic compartment model with a physics-based model to estimate nickel release from an implanted device. This model links the rate of in-vitro nickel release from a cardiovascular device to serum nickel concentrations, an easily measured endpoint, to estimate the rate and extent of in-vivo nickel release from an implanted device. The model was initially parameterized using data in the literature on in-vitro nickel release from a nickel-containing alloy (nitinol) and baseline serum nickel levels in humans. The results of this first step were then used to validate specific components of the model. The remaining unknown quantities were fit using serum values reported in patients following implantation with nitinol atrial occluder devices. The model is not only consistent with levels of nickel in serum and urine of patients following treatment with the atrial occluders, but also the optimized parameters in the model were all physiologically plausible. The congruity of the model with available data suggests that it can provide a framework to interpret nickel biomonitoring data and use data from in-vitro nickel immersion tests to estimate in-vivo nickel release from implanted cardiovascular devices. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Saylor, David M AU - Adidharma, Lingga AU - Fisher, Jeffrey W AU - Brown, Ronald P AD - Center for Devices and Radiological Health, FDA, Silver Spring, MD 20993, USA. Electronic address: david.saylor@fda.hhs.gov. ; Center for Devices and Radiological Health, FDA, Silver Spring, MD 20993, USA. ; National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1 EP - 8 VL - 80 KW - Index Medicus KW - Compartment model KW - Nickel release KW - Biomonitoring KW - Nitinol KW - Diffusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816637708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=A+biokinetic+model+for+nickel+released+from+cardiovascular+devices.&rft.au=Saylor%2C+David+M%3BAdidharma%2C+Lingga%3BFisher%2C+Jeffrey+W%3BBrown%2C+Ronald+P&rft.aulast=Saylor&rft.aufirst=David&rft.date=2016-10-01&rft.volume=80&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.05.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.05.019 ER - TY - JOUR T1 - Parental investment responses to a low birth weight outcome: who compensates and who reinforces? AN - 1811885882; PQ0003517755 AB - This study analyzes how parental investment responds to a low birth weight (LBW) outcome and finds important differences in investment responses by maternal education. High school dropouts reinforce a LBW outcome by providing less investment in the human capital of their LBW children relative to their normal birth weight children whereas higher educated mothers compensate by investing more in their LBW children. In addition, an increase in the number of LBW siblings present in the home raises investment in a child, which is consistent with reinforcement, but this positive effect tends to be concentrated among high school dropouts. These results suggest that studies analyzing the effects of LBW on child outcomes that do not account for heterogeneity in investment responses to a LBW outcome by maternal education may overestimate effects of LBW on child outcomes for those born to low-educated mothers and underestimate such effects for those born to high-educated mothers. JF - Journal of Population Economics AU - Restrepo, Brandon J AD - Office of the Commissioner, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA, brandon.restrepo@eui.eu Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 969 EP - 989 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 29 IS - 4 SN - 0933-1433, 0933-1433 KW - Environment Abstracts KW - Birth weight KW - Human capital KW - Low-birth-weight KW - Schools KW - Economics KW - Siblings KW - Children KW - ENA 04:Environmental Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811885882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Population+Economics&rft.atitle=Parental+investment+responses+to+a+low+birth+weight+outcome%3A+who+compensates+and+who+reinforces%3F&rft.au=Restrepo%2C+Brandon+J&rft.aulast=Restrepo&rft.aufirst=Brandon&rft.date=2016-10-01&rft.volume=29&rft.issue=4&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=Journal+of+Population+Economics&rft.issn=09331433&rft_id=info:doi/10.1007%2Fs00148-016-0590-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 57 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Birth weight; Human capital; Schools; Low-birth-weight; Economics; Siblings; Children DO - http://dx.doi.org/10.1007/s00148-016-0590-3 ER - TY - JOUR T1 - Latent Tuberculosis Infection Among Immigrant and Refugee Children Arriving in the United States: 2010 AN - 1811041183 AB - Immigrants and refugees age 2-14 years entering the United States from countries with estimated tuberculosis (TB) incidence rate [greater than or equal to]20 per 100,000 population are screened for TB. Children with TB disease are treated before US arrival. Children with positive tuberculin skin tests (TST), but negative TB evaluation during their pre-immigration examination, are classified with latent TB infection (LTBI) and are recommended for re-evaluation post-arrival. We examined post-immigration TB evaluation and therapy for children arriving with LTBI. We reviewed medical exam data from immigrant children with medical conditions and all refugee children arriving during 2010. Medical examination data were available for 67,334 children. Of these, 8231 (12 %) had LTBI pre-immigration; 5749 (70 %) were re-evaluated for TB post-immigration, and 64 % were retested by TST or IGRA. The pre-immigration LTBI diagnosis was changed for 38 % when retested by TST and for 71 % retested by IGRA. Estimated LTBI therapy initiation and completion rates were 68 and 12 %. In this population, testing with IGRA may limit the number of children targeted for therapy. Increased pre-immigration TB screening with post-immigration follow-up evaluation leading to completion of LTBI therapy should be encouraged to prevent TB reactivation. JF - Journal of Immigrant and Minority Health AU - Taylor, Eboni M AU - Painter, John AU - Posey, Drew L AU - Zhou, Weigong AU - Shetty, Sharmila AD - Division of Global Migration and Quarantine, National Center of Emerging Zoonotic and Infectious Diseases, United States Centers for Disease Control and Prevention, Mailstop E-04, Atlanta, GA, USA; United States Public Health Service Commissioned Corps, Washington, DC, USA ; Division of Global Migration and Quarantine, National Center of Emerging Zoonotic and Infectious Diseases, United States Centers for Disease Control and Prevention, Mailstop E-04, Atlanta, GA, USA; United States Public Health Service Commissioned Corps, Washington, DC, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 966 EP - 970 CY - New York PB - Springer Science & Business Media VL - 18 IS - 5 SN - 1557-1912 KW - Medical Sciences KW - Pediatric KW - Tuberculin skin test KW - Interferon gamma release assay KW - Migrants KW - Infection KW - Screening KW - Medical conditions KW - Tuberculosis KW - Immigration KW - Children KW - Diagnosis KW - Refugees KW - Immigrants KW - Initiation KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811041183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Latent+Tuberculosis+Infection+Among+Immigrant+and+Refugee+Children+Arriving+in+the+United+States%3A+2010&rft.au=Taylor%2C+Eboni+M%3BPainter%2C+John%3BPosey%2C+Drew+L%3BZhou%2C+Weigong%3BShetty%2C+Sharmila&rft.aulast=Taylor&rft.aufirst=Eboni&rft.date=2016-10-01&rft.volume=18&rft.issue=5&rft.spage=966&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-015-0273-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1007/s10903-015-0273-2 ER - TY - JOUR T1 - Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations. AN - 1859739552; 27650663 AB - For several decades, regulatory testing schemes for genetic damage have been standardized where the tests being utilized examined mutations and structural and numerical chromosomal damage. This has served the genetic toxicity community well when most of the substances being tested were amenable to such assays. The outcome from this testing is usually a dichotomous (yes/no) evaluation of test results, and in many instances, the information is only used to determine whether a substance has carcinogenic potential or not. Over the same time period, mechanisms and modes of action (MOAs) that elucidate a wider range of genomic damage involved in many adverse health outcomes have been recognized. In addition, a paradigm shift in applied genetic toxicology is moving the field toward a more quantitative dose-response analysis and point-of-departure (PoD) determination with a focus on risks to exposed humans. This is directing emphasis on genomic damage that is likely to induce changes associated with a variety of adverse health outcomes. This paradigm shift is moving the testing emphasis for genetic damage from a hazard identification only evaluation to a more comprehensive risk assessment approach that provides more insightful information for decision makers regarding the potential risk of genetic damage to exposed humans. To enable this broader context for examining genetic damage, a next generation testing strategy needs to take into account a broader, more flexible approach to testing, and ultimately modeling, of genomic damage as it relates to human exposure. This is consistent with the larger risk assessment context being used in regulatory decision making. As presented here, this flexible approach for examining genomic damage focuses on testing for relevant genomic effects that can be, as best as possible, associated with an adverse health effect. The most desired linkage for risk to humans would be changes in loci associated with human diseases, whether in somatic or germ cells. The outline of a flexible approach and associated considerations are presented in a series of nine steps, some of which can occur in parallel, which was developed through a collaborative effort by leading genetic toxicologists from academia, government, and industry through the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Genetic Toxicology Technical Committee (GTTC). The ultimate goal is to provide quantitative data to model the potential risk levels of substances, which induce genomic damage contributing to human adverse health outcomes. Any good risk assessment begins with asking the appropriate risk management questions in a planning and scoping effort. This step sets up the problem to be addressed (e.g., broadly, does genomic damage need to be addressed, and if so, how to proceed). The next two steps assemble what is known about the problem by building a knowledge base about the substance of concern and developing a rational biological argument for why testing for genomic damage is needed or not. By focusing on the risk management problem and potential genomic damage of concern, the next step of assay(s) selection takes place. The work-up of the problem during the earlier steps provides the insight to which assays would most likely produce the most meaningful data. This discussion does not detail the wide range of genomic damage tests available, but points to types of testing systems that can be very useful. Once the assays are performed and analyzed, the relevant data sets are selected for modeling potential risk. From this point on, the data are evaluated and modeled as they are for any other toxicology endpoint. Any observed genomic damage/effects (or genetic event(s)) can be modeled via a dose-response analysis and determination of an estimated PoD. When a quantitative risk analysis is needed for decision making, a parallel exposure assessment effort is performed (exposure assessment is not detailed here as this is not the focus of this discussion; guidelines for this assessment exist elsewhere). Then the PoD for genomic damage is used with the exposure information to develop risk estimations (e.g., using reference dose (RfD), margin of exposure (MOE) approaches) in a risk characterization and presented to risk managers for informing decision making. This approach is applicable now for incorporating genomic damage results into the decision-making process for assessing potential adverse outcomes in chemically exposed humans and is consistent with the ILSI HESI Risk Assessment in the 21st Century (RISK21) roadmap. This applies to any substance to which humans are exposed, including pharmaceuticals, agricultural products, food additives, and other chemicals. It is time for regulatory bodies to incorporate the broader knowledge and insights provided by genomic damage results into the assessments of risk to more fully understand the potential of adverse outcomes in chemically exposed humans, thus improving the assessment of risk due to genomic damage. The historical use of genomic damage data as a yes/no gateway for possible cancer risk has been too narrowly focused in risk assessment. The recent advances in assaying for and understanding genomic damage, including eventually epigenetic alterations, obviously add a greater wealth of information for determining potential risk to humans. Regulatory bodies need to embrace this paradigm shift from hazard identification to quantitative analysis and to incorporate the wider range of genomic damage in their assessments of risk to humans. The quantitative analyses and methodologies discussed here can be readily applied to genomic damage testing results now. Indeed, with the passage of the recent update to the Toxic Substances Control Act (TSCA) in the US, the new generation testing strategy for genomic damage described here provides a regulatory agency (here the US Environmental Protection Agency (EPA), but suitable for others) a golden opportunity to reexamine the way it addresses risk-based genomic damage testing (including hazard identification and exposure). Environ. Mol. Mutagen., 2016. © 2016 The Authors. Environmental and Molecular Mutagenesis Published by Wiley Periodicals, Inc. © 2016 The Authors. Environmental and Molecular Mutagenesis Published by Wiley Periodicals, Inc. JF - Environmental and molecular mutagenesis AU - Dearfield, Kerry L AU - Gollapudi, B Bhaskar AU - Bemis, Jeffrey C AU - Benz, R Daniel AU - Douglas, George R AU - Elespuru, Rosalie K AU - Johnson, George E AU - Kirkland, David J AU - LeBaron, Matthew J AU - Li, Albert P AU - Marchetti, Francesco AU - Pottenger, Lynn H AU - Rorije, Emiel AU - Tanir, Jennifer Y AU - Thybaud, Veronique AU - van Benthem, Jan AU - Yauk, Carole L AU - Zeiger, Errol AU - Luijten, Mirjam AD - U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, District of Columbia. ; Exponent® Inc, Center for Toxicology and Mechanistic Biology, Midland, Michigan. ; Litron Laboratories, Rochester, New York. ; OmnyCorp, Rockville, Maryland. ; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada. ; U.S. Food and Drug Administration, CDRH/OSEL DBCMS, Silver Spring, Maryland. ; Institute of Life Science, College of Medicine, Swansea University, Swansea, SA2 8PP, United Kingdom. ; Kirkland Consulting, Tadcaster, LS24 OAS, United Kingdom. ; The Dow Chemical Company, Molecular, Cellular, and Biochemical Toxicology, Midland, Michigan. ; In Vitro ADMET Laboratories LLC, Columbia, Maryland. ; Formerly of The Dow Chemical Company, Toxicology & Environmental Research and Consulting now with Olin Corporation, Midland, Michigan. ; National Institute for Public Health and the Environment (RIVM), Center for Safety of Substances and Products, Bilthoven, 3720 BA, The Netherlands. ; ILSI Health and Environmental Sciences Institute (HESI), Washington, District of Columbia. jtanir@hesiglobal.org. ; Sanofi, Drug Disposition, Safety and Animal Research, Vitry-sur-Seine, France. ; National Institute for Public Health and the Environment (RIVM), Center for Health Protection, Bilthoven, 3720 BA, The Netherlands. ; Errol Zeiger Consulting, Chapel Hill, North Carolina. Y1 - 2016/09/21/ PY - 2016 DA - 2016 Sep 21 KW - integrated testing strategy KW - exposure assessment KW - genetic toxicology KW - risk assessment KW - mutagenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859739552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Next+generation+testing+strategy+for+assessment+of+genomic+damage%3A+A+conceptual+framework+and+considerations.&rft.au=Dearfield%2C+Kerry+L%3BGollapudi%2C+B+Bhaskar%3BBemis%2C+Jeffrey+C%3BBenz%2C+R+Daniel%3BDouglas%2C+George+R%3BElespuru%2C+Rosalie+K%3BJohnson%2C+George+E%3BKirkland%2C+David+J%3BLeBaron%2C+Matthew+J%3BLi%2C+Albert+P%3BMarchetti%2C+Francesco%3BPottenger%2C+Lynn+H%3BRorije%2C+Emiel%3BTanir%2C+Jennifer+Y%3BThybaud%2C+Veronique%3Bvan+Benthem%2C+Jan%3BYauk%2C+Carole+L%3BZeiger%2C+Errol%3BLuijten%2C+Mirjam&rft.aulast=Dearfield&rft.aufirst=Kerry&rft.date=2016-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.22045 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/em.22045 ER - TY - JOUR T1 - Differential Activation of a Mouse Estrogen Receptor β Isoform (mERβ2) with Endocrine-Disrupting Chemicals (EDCs). AN - 1859740562; 27634370 AB - Endocrine disrupting compounds (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects have been reported in animal studies and extrapolated to human studies. Unlike humans, rodents express a novel isoform of ERβ (mERβ2) with a modified ligand binding domain sequence. EDC activity through this isoform remains uncharacterized. We identified the expression pattern of mERβ2 in mouse tissues and assessed the estrogenic activity of EDCs through mERβ2. mERβ2 mRNA expression was measured in mouse tissues. HepG2 cells were used to assess the transactivation activity of mERβ isoforms with EDCs and ER coactivators. 293A cells transiently transfected with mER isoforms were used to detect EDC-mediated changes in endogenous ER target gene expression. Expression of mERβ2 mRNA was detected in mouse reproductive tissues (ovary, testis, and prostate) and lung and colon tissues from both female and male mice. Five (E2, DES, DPN, BPAF, Coum, 1-BP) of sixteen compounds tested by reporter assay had estrogenic activity through mERβ2. mERβ2 had a compound-specifc negative effect on ERβ/ligand-mediated activity and ER target genes when co-expressed with mERβ1. mERβ2 recruited coactivators SRC2 or SRC3 in the presence of EDCs, but showed less recruitment than mERβ1. mERβ2 showed weaker estrogenic activity than mERβ1 in our in vitro system, and can dampen mERβ1 activity. In vivo models of EDC activity and ER-mediated toxicity should consider the role of mERβ2, as rodent tissue responses involving mERβ2 may not be reproduced in human biology. JF - Environmental health perspectives AU - Donoghue, Lauren J AU - Neufeld, Thomas I AU - Li, Yin AU - Arao, Yukitomo AU - Coons, Laurel A AU - Korach, Kenneth S AD - Receptor Biology Section, Reproductive and Developmental Biology Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/09/16/ PY - 2016 DA - 2016 Sep 16 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859740562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Differential+Activation+of+a+Mouse+Estrogen+Receptor+%CE%B2+Isoform+%28mER%CE%B22%29+with+Endocrine-Disrupting+Chemicals+%28EDCs%29.&rft.au=Donoghue%2C+Lauren+J%3BNeufeld%2C+Thomas+I%3BLi%2C+Yin%3BArao%2C+Yukitomo%3BCoons%2C+Laurel+A%3BKorach%2C+Kenneth+S&rft.aulast=Donoghue&rft.aufirst=Lauren&rft.date=2016-09-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Development of a PBPK model of thiocyanate in rats with an extrapolation to humans: A computational study to quantify the mechanism of action of thiocyanate kinetics in thyroid. AN - 1814144235; 27445130 AB - Thyroid homeostasis can be disturbed due to thiocyanate exposure from the diet or tobacco smoke. Thiocyanate inhibits both thyroidal uptake of iodide, via the sodium-iodide symporter (NIS), and thyroid hormone (TH) synthesis in the thyroid, via thyroid peroxidase (TPO), but the mode of action of thiocyanate is poorly quantified in the literature. The characterization of the link between intra-thyroidal thiocyanate concentrations and dose of exposure is crucial for assessing the risk of thyroid perturbations due to thiocyanate exposure. We developed a PBPK model for thiocyanate that describes its kinetics in the whole-body up to daily doses of 0.15mmol/kg, with a mechanistic description of the thyroidal kinetics including NIS, passive diffusion, and TPO. The model was calibrated in a Bayesian framework using published studies in rats. Goodness-of-fit was satisfactory, especially for intra-thyroidal thiocyanate concentrations. Thiocyanate kinetic processes were quantified in vivo, including the metabolic clearance by TPO. The passive diffusion rate was found to be greater than NIS-mediated uptake rate. The model captured the dose-dependent kinetics of thiocyanate after acute and chronic exposures. Model behavior was evaluated using a Morris screening test. The distribution of thiocyanate into the thyroid was found to be determined primarily by the partition coefficient, followed by NIS and passive diffusion; the impact of the latter two mechanisms appears to increase at very low doses. Extrapolation to humans resulted in good predictions of thiocyanate kinetics during chronic exposure. The developed PBPK model can be used in risk assessment to quantify dose-response effects of thiocyanate on TH. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Willemin, Marie-Emilie AU - Lumen, Annie AD - Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Annie.Lumen@fda.hhs.gov. Y1 - 2016/09/15/ PY - 2016 DA - 2016 Sep 15 SP - 19 EP - 34 VL - 307 KW - Index Medicus KW - Bayesian KW - Thyroid KW - TPO KW - PBPK model KW - Thiocyanate KW - NIS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814144235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Development+of+a+PBPK+model+of+thiocyanate+in+rats+with+an+extrapolation+to+humans%3A+A+computational+study+to+quantify+the+mechanism+of+action+of+thiocyanate+kinetics+in+thyroid.&rft.au=Willemin%2C+Marie-Emilie%3BLumen%2C+Annie&rft.aulast=Willemin&rft.aufirst=Marie-Emilie&rft.date=2016-09-15&rft.volume=307&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.07.011 ER - TY - JOUR T1 - Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury. AN - 1819904076; 27623738 AB - Non-penetrating or mild traumatic brain injury (mTBI) is commonly experienced in accidents, the battlefield and in full-contact sports. Astrocyte cellular edema is one of the major factors that leads to high morbidity post-mTBI. Various studies have reported an upregulation of aquaporin-4 (AQP4), a water channel protein, following brain injury. AZA is an antiepileptic drug that has been shown to inhibit AQP4 expression and in this study we investigate the drug as a therapeutic to mitigate the extent of mTBI induced cellular edema. We hypothesized that mTBI-mediated astrocyte dysfunction, initiated by increased intracellular volume, could be reduced when treated with AZA. We tested our hypothesis in a three-dimensional in vitro astrocyte model of mTBI. Samples were subject to no stretch (control) or one high-speed stretch (mTBI) injury. AQP4 expression was significantly increased 24 hours after mTBI. mTBI resulted in a significant increase in the cell swelling within 30 min of mTBI, which was significantly reduced in the presence of AZA. Cell death and expression of S100B was significantly reduced when AZA was added shortly before mTBI stretch. Overall, our data point to occurrence of astrocyte swelling immediately following mTBI, and AZA as a promising treatment to mitigate downstream cellular mortality. JF - Scientific reports AU - Sturdivant, Nasya M AU - Smith, Sean G AU - Ali, Syed F AU - Wolchok, Jeffrey C AU - Balachandran, Kartik AD - Department of Biomedical Engineering, University of Arkansas, Fayetteville AR 72701, USA. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson AR 72079, USA. Y1 - 2016/09/14/ PY - 2016 DA - 2016 Sep 14 SP - 33330 VL - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819904076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Acetazolamide+Mitigates+Astrocyte+Cellular+Edema+Following+Mild+Traumatic+Brain+Injury.&rft.au=Sturdivant%2C+Nasya+M%3BSmith%2C+Sean+G%3BAli%2C+Syed+F%3BWolchok%2C+Jeffrey+C%3BBalachandran%2C+Kartik&rft.aulast=Sturdivant&rft.aufirst=Nasya&rft.date=2016-09-14&rft.volume=6&rft.issue=&rft.spage=33330&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep33330 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep33330 ER - TY - JOUR T1 - Krüppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death. AN - 1818339374; 27451392 AB - Glucocorticoid receptor (GR) signaling has recently been shown to play a direct role in the regulation of cardiomyocyte function. In this study, we investigated the potential role of KLF13 as a downstream effector of GR action utilizing both in vivo and in vitro approaches. Our data show that KLF13 mRNA and protein levels are significantly diminished in the hearts of mice lacking GR in cardiomyocytes. Glucocorticoid administration up-regulated Klf13 mRNA in the mouse heart, in isolated primary cardiomyocytes, and in immortal cardiomyocyte cell lines. Glucocorticoid Klf13 gene expression was abolished by treatment with a GR antagonist (RU486) or by knockdown of GR in cardiomyocytes. Moreover, glucocorticoid induction of Klf13 mRNA was resistant to de novo protein synthesis inhibition, demonstrating that Klf13 is a direct glucocorticoid receptor gene target. A glucocorticoid responsive element (GRE) was identified in the Klf13 gene and its function was verified by chromatin immunoprecipitation in HL-1 cells and mouse hearts. Functional studies showed that GR regulation of Klf13 is critical to protect cardiomyocytes from DNA damage and cell death induced by cobalt(II) chloride hexahydrate (CoCl2·6H2O) and the antineoplastic drug doxorubicin. These results established a novel role for GR and KLF13 signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. JF - The Journal of biological chemistry AU - Cruz-Topete, Diana AU - He, Bo AU - Xu, Xiaojiang AU - Cidlowski, John A AD - From the Laboratory of Signal Transduction and. ; Integrative Bioinformatics, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709. ; From the Laboratory of Signal Transduction and cidlows1@niehs.nih.gov. Y1 - 2016/09/09/ PY - 2016 DA - 2016 Sep 09 SP - 19374 EP - 19386 VL - 291 IS - 37 KW - Index Medicus KW - Kruppel-like factor (KLF) KW - cardiomyocyte KW - gene regulation KW - hypoxia KW - glucocorticoid receptor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1818339374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Kr%C3%BCppel-like+Factor+13+Is+a+Major+Mediator+of+Glucocorticoid+Receptor+Signaling+in+Cardiomyocytes+and+Protects+These+Cells+from+DNA+Damage+and+Death.&rft.au=Cruz-Topete%2C+Diana%3BHe%2C+Bo%3BXu%2C+Xiaojiang%3BCidlowski%2C+John+A&rft.aulast=Cruz-Topete&rft.aufirst=Diana&rft.date=2016-09-09&rft.volume=291&rft.issue=37&rft.spage=19374&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M116.725903 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1074/jbc.M116.725903 ER - TY - JOUR T1 - Physiologically Based Pharmacokinetic Prediction of Linezolid and Emtricitabine in Neonates and Infants. AN - 1859728504; 27596256 AB - Modeling and simulation approaches are increasingly being utilized in pediatric drug development. Physiologically based pharmacokinetic (PBPK) modeling offers an enhanced ability to predict age-related changes in pharmacokinetics in the pediatric population. In the current study, adult PBPK models were developed for the renally excreted drugs linezolid and emtricitabine. PBPK models were then utilized to predict pharmacokinetics in pediatric patients for various age groups from the oldest to the youngest patients in a stepwise approach. Pharmacokinetic predictions for these two drugs in the pediatric population, including infants and neonates, were within a twofold range of clinical observations. Based on this study, linezolid and emtricitabine pediatric PBPK models incorporating the ontogeny in renal maturation describe the pharmacokinetic differences between adult and pediatric populations, even though the contribution of renal clearance to the total clearance of two drugs was very different (30 % for linezolid vs. 86 % for emtricitabine). These results suggest that PBPK modeling may provide one option to help predict the pharmacokinetics of renally excreted drugs in neonates and infants. JF - Clinical pharmacokinetics AU - Duan, Peng AU - Fisher, Jeffrey W AU - Yoshida, Kenta AU - Zhang, Lei AU - Burckart, Gilbert J AU - Wang, Jian AD - Office of New Drug Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA. ; National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR, 72079, USA. ; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Building 51, Rm 2154, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA. ; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Building 51, Rm 2154, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA. jian.wang@fda.hhs.gov. Y1 - 2016/09/06/ PY - 2016 DA - 2016 Sep 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859728504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacokinetics&rft.atitle=Physiologically+Based+Pharmacokinetic+Prediction+of+Linezolid+and+Emtricitabine+in+Neonates+and+Infants.&rft.au=Duan%2C+Peng%3BFisher%2C+Jeffrey+W%3BYoshida%2C+Kenta%3BZhang%2C+Lei%3BBurckart%2C+Gilbert+J%3BWang%2C+Jian&rft.aulast=Duan&rft.aufirst=Peng&rft.date=2016-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacokinetics&rft.issn=1179-1926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES BIODOSIMETRY AND RADIOLOGICAL/NUCLEAR MEDICAL COUNTERMEASURE PROGRAMS AN - 1855077288; PQ0003960997 AB - The United States Department of Health and Human Services (HHS) is fully committed to the development of medical countermeasures to address national security threats from chemical, biological, radiological, and nuclear agents. Through the Public Health Emergency Medical Countermeasures Enterprise, HHS has launched and managed a multi-agency, comprehensive effort to develop and operationalize medical countermeasures. Within HHS, development of medical countermeasures includes the National Institutes of Health (NIH), (led by the National Institute of Allergy and Infectious Diseases), the Office of the Assistant Secretary of Preparedness and Response/Biomedical Advanced Research and Development Authority (BARDA); with the Division of Medical Countermeasure Strategy and Requirements, the Centers for Disease Control and Prevention, and the Food and Drug Administration as primary partners in this endeavor. This paper describes various programs and coordinating efforts of BARDA and NIH for the development of medical countermeasures for radiological and nuclear threats. JF - Radiation Protection Dosimetry AU - Homer, Mary J AU - Raulli, Robert AU - Dicarlo-Cohen, Andrea L AU - Esker, John AU - Hrdina, Chad AU - Maidment, Bert W AU - Moyer, Brian AU - Rios, Carmen AU - Macchiarini, Francesca AU - Prasanna, Pataje G AU - Wathen, Lynne AD - Biomedical Advanced Research and Development Authority, Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services , 330 Independence Ave., SW, Room G644, Washington, DC 20201, USA, mary.homer@hhs.gov Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 85 EP - 98 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 171 IS - 1 SN - 0144-8420, 0144-8420 KW - Biotechnology and Bioengineering Abstracts; Environment Abstracts KW - Food hypersensitivity KW - Dosimetry KW - Disease control KW - Drug development KW - Allergies KW - Public health KW - Security KW - USA KW - Prevention KW - Radiation KW - Infectious diseases KW - Drugs KW - Research programs KW - W 30935:Food Biotechnology KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855077288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=UNITED+STATES+DEPARTMENT+OF+HEALTH+AND+HUMAN+SERVICES+BIODOSIMETRY+AND+RADIOLOGICAL%2FNUCLEAR+MEDICAL+COUNTERMEASURE+PROGRAMS&rft.au=Homer%2C+Mary+J%3BRaulli%2C+Robert%3BDicarlo-Cohen%2C+Andrea+L%3BEsker%2C+John%3BHrdina%2C+Chad%3BMaidment%2C+Bert+W%3BMoyer%2C+Brian%3BRios%2C+Carmen%3BMacchiarini%2C+Francesca%3BPrasanna%2C+Pataje+G%3BWathen%2C+Lynne&rft.aulast=Homer&rft.aufirst=Mary&rft.date=2016-09-01&rft.volume=171&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncw226 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Food hypersensitivity; Infectious diseases; Dosimetry; Disease control; Drug development; Public health; Security; Prevention; Radiation; Drugs; Allergies; Research programs; USA DO - http://dx.doi.org/10.1093/rpd/ncw226 ER - TY - JOUR T1 - Longitudinal diffusion tensor imaging of the rat brain after hexachlorophene exposure AN - 1837326812; PQ0003736445 AB - Longitudinal MRI employing diffusion tensor imaging and T2 mapping approaches has been applied to investigate the mechanisms of white matter damage caused by acute hexachlorophene neurotoxicity in rats in vivo. Male Sprague-Dawley rats were administered hexachlorophene orally once a day for five consecutive days at a dose of 30mg/kg and were monitored in 7T MRI scanner at days 0 (baseline), 3, 6, 13, and 20 following the first hexachlorophene dose. Quantitative T2 maps as well as a number of diffusion tensor parameters (fractional anisotropy, radial and axial diffusivity, apparent diffusion coefficient, and trace) were calculated from corresponding MR images. T2, as well as all diffusion tensor derived parameters (except fractional anisotropy) showed significant changes during the course of neurotoxicity development. These changes peaked at 6days after the first dose of hexachlorophene (one day after the last dose) and recovered to practically baseline levels at the end of observation (20days from the first dose). While such changes in diffusivity and T2 relaxation clearly demonstrate myelin perturbations consistent with edema, the lack of changes of fractional anisotropy suggests that the structure of the myelin sheath was not disrupted significantly by hexachlorophene in this study. This is also confirmed by the rapid recovery of all observed MRI parameters after cessation of hexachlorophene exposure. JF - Neurotoxicology AU - Ramu, Jaivijay AU - Konak, Tetyana AU - Paule, Merle G AU - Hanig, Joseph P AU - Liachenko, Serguei AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, United States Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 225 EP - 232 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 56 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - AD axial diffusivity KW - cc Corpus Callosum KW - Comm Commissures KW - DTI diffusion tensor imaging KW - fim Fimbria KW - HC hexachlorophene KW - IC Internal Capsule KW - FA fraction anisotropy KW - RD radial diffusivity KW - DTI KW - Axial diffusivity KW - Radial diffusivity KW - Fractional anisotropy KW - Hexachlorophene KW - Anisotropy KW - Myelin KW - Magnetic resonance imaging KW - Neurotoxicity KW - Brain KW - Substantia alba KW - Edema KW - Diffusion coefficient KW - N3 11028:Neuropharmacology & toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837326812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Longitudinal+diffusion+tensor+imaging+of+the+rat+brain+after+hexachlorophene+exposure&rft.au=Ramu%2C+Jaivijay%3BKonak%2C+Tetyana%3BPaule%2C+Merle+G%3BHanig%2C+Joseph+P%3BLiachenko%2C+Serguei&rft.aulast=Ramu&rft.aufirst=Jaivijay&rft.date=2016-09-01&rft.volume=56&rft.issue=&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2016.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Anisotropy; Myelin; Hexachlorophene; Neurotoxicity; Magnetic resonance imaging; Brain; Edema; Substantia alba; Diffusion coefficient DO - http://dx.doi.org/10.1016/j.neuro.2016.08.011 ER - TY - JOUR T1 - Single and repeated exposures to the volatile anesthetic isoflurane do not impair operant performance in aged rats AN - 1837310302; PQ0003736451 AB - Postoperative Cognitive Dysfunction (POCD) is a complication that can occur in the elderly after anesthesia and surgery and is characterized by impairments in information processing, memory, and executive function. Currently, it is unclear whether POCD is due to the effects of surgery, anesthesia, or perhaps some interaction between these or other perioperative variables. Studies in rodents suggest that the development of POCD may be related directly to anesthesia-induced neuroactivity. Volatile anesthetics have been shown to increase cellular inflammation and apoptosis within the hippocampus of aged rodents, while producing corresponding impairments in hippocampal-dependent brain functions. However, it is unclear whether volatile anesthetics can affect additional aspects of cognition that do not primarily depend upon the hippocampus. The purpose of this study was to use established operant tests to examine the effects of isoflurane on aspects of behavioral inhibition, learning, and motivation in aged rats. Twenty-one adult Sprague-Dawley rats (11 male, 10 female) were trained to perform fixed consecutive number (FCN), incremental repeated acquisition (IRA), and progressive ratio (PR) tasks for a minimum of 15 months prior to receiving anesthesia. At 23 months of age, rats were exposed to 1.3% isoflurane or medical grade air for 2h. Initial results revealed that a 2h exposure to isoflurane had no effect on IRA, FCN, or PR performance. Thus, rats received 3 additional exposures to 1.3% isoflurane or medical grade air: 2, 4 and 6h exposures with 2 weeks elapsing before exposure two, 3 weeks elapsing between exposures two and three, and 2 weeks elapsing between exposures three and four. These additional exposures had no observable effects on performance of any operant task. These results suggest that single and repeated exposures to isoflurane do not impair the performance of aged rats in tasks designed to measure behavioral inhibition, learning, and motivation. This lack of significant effect suggests that the impairments associated with isoflurane exposure may not generalize to all aspects of cognition, but may be selective to tasks that primarily measure spatial memory processes. JF - Neurotoxicology AU - Walters, Jennifer L AU - Chelonis, John J AU - Fogle, Charles M AU - Orser, Beverley A AU - Paule, Merle G AD - National Center for Toxicological Research (NCTR)/FDA, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, United States Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 159 EP - 169 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 56 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Anesthesia KW - Isoflurane KW - Operant behavior KW - Fixed consecutive number KW - Incremental repeated acquisition KW - Learning KW - Age KW - Apoptosis KW - Motivation KW - Operant conditioning KW - Hippocampus KW - Brain KW - Anesthetics KW - Cognition KW - Executive function KW - spatial memory KW - Memory KW - Cognitive ability KW - Volatiles KW - Surgery KW - Information processing KW - Geriatrics KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837310302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Single+and+repeated+exposures+to+the+volatile+anesthetic+isoflurane+do+not+impair+operant+performance+in+aged+rats&rft.au=Walters%2C+Jennifer+L%3BChelonis%2C+John+J%3BFogle%2C+Charles+M%3BOrser%2C+Beverley+A%3BPaule%2C+Merle+G&rft.aulast=Walters&rft.aufirst=Jennifer&rft.date=2016-09-01&rft.volume=56&rft.issue=&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2016.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Age; Learning; Apoptosis; Operant conditioning; Motivation; Hippocampus; Brain; Anesthetics; Cognition; Executive function; spatial memory; Memory; Anesthesia; Volatiles; Cognitive ability; Information processing; Surgery; Isoflurane; Geriatrics DO - http://dx.doi.org/10.1016/j.neuro.2016.07.012 ER - TY - JOUR T1 - INHALED AEROSOL DOSIMETRY: SOME CURRENT RESEARCH NEEDS. AN - 1835687165; 27493295 AB - After the presentation of 60 papers at the conference "Advancing Aerosol Dosimetry Research" (October 24-25, 2014 in Irvine, CA, USA), attendees submitted written descriptions of needed research. About 40 research needs were submitted. The suggestions fell into six broad categories: 1) Access to detailed anatomic data; 2) Access to subject-specific aerosol deposition datasets; 3) Improving current inhaled aerosol deposition models; 4) Some current experimental data needs and hot topics; 5) Linking exposure and deposition modeling to health endpoints; and 6) Developing guidelines for appropriate validation of dosimetry and risk assessment models. Summaries of suggestions are provided here as an update on research needs related to inhaled aerosol dosimetry modeling. Taken together, the recommendations support the overarching need for increased collaborations between dose modelers and those that use the models for risk assessments, aerosol medicine applications, design of toxicology experiments, and extrapolation across species. This paper is only a snapshot in time of perceived research needs from the conference attendees; it does not carry the approval of any agency or other group that plans research priorities or that funds research. JF - Journal of aerosol science AU - Darquenne, Chantal AU - Hoover, Mark D AU - Phalen, Robert F AD - Department of Medicine, University of California, San Diego, CA 92093-0623, USA. ; Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, VA 26505-2888, USA. ; Department of Medicine, Center for Occupational and Environmental Health, University of California, Irvine, CA 92617-1830, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1 EP - 5 VL - 99 SN - 0021-8502, 0021-8502 KW - particle deposition KW - risk assessment KW - lung models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835687165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+aerosol+science&rft.atitle=INHALED+AEROSOL+DOSIMETRY%3A+SOME+CURRENT+RESEARCH+NEEDS.&rft.au=Darquenne%2C+Chantal%3BHoover%2C+Mark+D%3BPhalen%2C+Robert+F&rft.aulast=Darquenne&rft.aufirst=Chantal&rft.date=2016-09-01&rft.volume=99&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+aerosol+science&rft.issn=00218502&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Bridging the gap between exposure assessment and inhalation toxicology: Some insights from the carbon nanotube experience. AN - 1835665541; 27546900 AB - The early incorporation of exposure assessment can be invaluable to help design, prioritize, and interpret toxicological studies or outcomes. The sum total of the exposure assessment findings combined with preliminary toxicology results allows for exposure-informed toxicological study design and the findings can then be integrated, together with available epidemiologic data, to provide health effect relevance. With regard to engineered nanomaterial inhalation toxicology in particular, a single type of material (e.g. carbon nanotube, graphene) can have a vast array of physicochemical characteristics resulting in the potential for varying toxicities. To compound the matter, the methodologies necessary to establish a material adequate for in vivo exposure testing raises questions on the applicability of the outcomes. From insights gained from evaluating carbon nanotubes, we recommend the following integrated approach involving exposure-informed hazard assessment and hazard-informed exposure assessment especially for materials as diverse as engineered nanomaterials: 1) market-informed identification of potential hazards and potentially exposed populations, 2) initial toxicity screening to drive prioritized assessments of exposure, 3) development of exposure assessment-informed chronic and sub-chronic in vivo studies, and 4) conduct of exposure- and hazard-informed epidemiological studies. JF - Journal of aerosol science AU - Erdely, Aaron AU - Dahm, Matthew M AU - Schubauer-Berigan, Mary K AU - Chen, Bean T AU - Antonini, James M AU - Hoover, Mark D AD - Health Effects Laboratory Division, NIOSH/HELD/PPRB, 1095 Willowdale Rd, MS-2015, Morgantown, WV 26505, USA. ; Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. ; Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 157 EP - 162 VL - 99 SN - 0021-8502, 0021-8502 KW - Inhalation KW - Epidemiology KW - Carbon nanotube KW - Exposure assessment KW - Toxicology KW - Nanomaterial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835665541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+aerosol+science&rft.atitle=Bridging+the+gap+between+exposure+assessment+and+inhalation+toxicology%3A+Some+insights+from+the+carbon+nanotube+experience.&rft.au=Erdely%2C+Aaron%3BDahm%2C+Matthew+M%3BSchubauer-Berigan%2C+Mary+K%3BChen%2C+Bean+T%3BAntonini%2C+James+M%3BHoover%2C+Mark+D&rft.aulast=Erdely&rft.aufirst=Aaron&rft.date=2016-09-01&rft.volume=99&rft.issue=&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Journal+of+aerosol+science&rft.issn=00218502&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S . mansoni Infections: A Randomized, Exploratory Phase 2 Trial AN - 1829442736 AB - Background Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or clinical studies. Methodology We conducted two single-blind, randomized exploratory Phase 2 trials in Schistosoma mansoni and S. haematobium-infected adolescents in northern and central Côte d'Ivoire. Our primary endpoints were cure rates (CRs) and egg reduction rates (ERRs) based on geometric mean and safety. Each subject was asked to provide two stool samples (S. mansoni trial) for Kato-Katz analysis or three urine samples (S. haematobium trial) for urine filtration and one finger prick for malaria screening at baseline and follow-up. Participants were randomly assigned to either moxidectin, Synriam, Synriam plus praziquantel or praziquantel. Principal Findings 128 adolescents (age: 12-17 years) were included in each study. Against S. haematobium moxidectin and Synriam revealed low efficacy. On the other hand, Synriam plus praziquantel and praziquantel yielded CRs of 60.0% and 38.5% and ERRs of 96.0% and 93.5%, respectively. CRs observed in the treatment of S. mansoni were 13.0%, 6.7%, 27.0%, and 27.6% for moxidectin, Synriam, Synriam plus praziquantel and praziquantel, respectively. ERRs ranged from 64.9% (Synriam) to 87.5% (praziquantel). Conclusion/Significance Synriam and moxidectin show low efficacy against S. haematobium, hence an ancillary benefit is not expected when these drugs are used for treating onchocerciasis and malaria in co-endemic settings. Further studies are needed to corroborate our findings that moxidectin and Synriam show moderate ERRs against S. mansoni. JF - PLoS Neglected Tropical Diseases AU - Barda, Beatrice AU - Coulibaly, Jean T AU - Puchkov, Maxim AU - Huwyler, Jörg AU - Hattendorf, Jan AU - Keiser, Jennifer Y1 - 2016/09// PY - 2016 DA - Sep 2016 CY - San Francisco PB - Public Library of Science VL - 10 IS - 9 KW - Medical Sciences--Communicable Diseases KW - Biology KW - Pharmaceuticals KW - Drugs KW - Public health KW - Teenagers KW - Studies KW - Infections KW - Urine KW - Tropical diseases KW - Funding KW - Malaria KW - Pharmaceutical sciences KW - Parasitology KW - Switzerland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1829442736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Efficacy+and+Safety+of+Moxidectin%2C+Synriam%2C+Synriam-Praziquantel+versus+Praziquantel+against+Schistosoma+haematobium+and+S+.+mansoni+Infections%3A+A+Randomized%2C+Exploratory+Phase+2+Trial&rft.au=Barda%2C+Beatrice%3BCoulibaly%2C+Jean+T%3BPuchkov%2C+Maxim%3BHuwyler%2C+J%C3%B6rg%3BHattendorf%2C+Jan%3BKeiser%2C+Jennifer&rft.aulast=Barda&rft.aufirst=Beatrice&rft.date=2016-09-01&rft.volume=10&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pntd.0005008 LA - English DB - ProQuest Central N1 - Name - University of Basel N1 - Copyright - © 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Infections: A Randomized, Exploratory Phase 2 Trial. PLoS Negl Trop Dis 10(9): e0005008. doi:10.1371/journal.pntd.0005008 N1 - Last updated - 2016-10-17 N1 - SubjectsTermNotLitGenreText - Switzerland DO - http://dx.doi.org/10.1371/journal.pntd.0005008 ER - TY - JOUR T1 - StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control AN - 1829442219 AB - Marco Albonico, Sören L. Becker, Peter Odermatt Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland Andrea Angheben Affiliation: Centre for Tropical Diseases, Sacro Cuore Hospital, Negrar, Verona, Italy Mariella Anselmi Affiliation: Centro de Epidemiología Comunitaria y Medicina Tropical, Esmeraldas, Ecuador Arancha Amor Affiliation: Mundo Sano Foundation, Buenos Aires, Argentina Beatrice Barda Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland Dora Buonfrate Affiliation: Centre for Tropical Diseases, Sacro Cuore Hospital, Negrar, Verona, Italy Philip Cooper Affiliation: Facultad de Ciencias Medicas, de la Salud y la Vida, Universidad Internacional del Ecuador, Quito, Ecuador Laurent Gétaz Affiliation: University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland Jennifer Keiser Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland Virak Khieu Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland, National Center for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia Antonio Montresor Affiliation: Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland José Muñoz Affiliation: ISGlobal, Barcelona Centre for International Health Research, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain Ana Requena-Méndez Affiliation: ISGlobal, Barcelona Centre for International Health Research, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain Lorenzo Savioli Affiliation: Global Schistosomiasis Alliance, Chavannes de Bogis, Switzerland Richard Speare [dagger] Deceased. [...]clinical, diagnostic, epidemiologic, treatment, and control aspects are not adequately addressed to allow for an effective management of the disease, both in clinical medicine and in public health programs [4]. JF - PLoS Neglected Tropical Diseases AU - Albonico, Marco AU - Becker, Sören L AU - Odermatt, Peter AU - Angheben, Andrea AU - Anselmi, Mariella AU - Amor, Arancha AU - Barda, Beatrice AU - Buonfrate, Dora AU - Cooper, Philip AU - Gétaz, Laurent AU - Keiser, Jennifer AU - Khieu, Virak AU - Montresor, Antonio AU - Muñoz, José AU - Requena-Méndez, Ana AU - Savioli, Lorenzo AU - Speare, Richard AU - Steinmann, Peter AU - Lieshout, Lisette van AU - Utzinger, Jürg AU - Bisoffi, Zeno AU - Group, StrongNet Working Y1 - 2016/09// PY - 2016 DA - Sep 2016 CY - San Francisco PB - Public Library of Science VL - 10 IS - 9 KW - Medical Sciences--Communicable Diseases KW - Tropical diseases KW - Colleges & universities KW - Abdomen KW - Hospitals KW - Disease KW - Public health KW - Infections KW - Medical research KW - Drug dosages KW - Funding KW - Malaria KW - Parasitology KW - Working groups KW - Switzerland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1829442219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=StrongNet%3A+An+International+Network+to+Improve+Diagnostics+and+Access+to+Treatment+for+Strongyloidiasis+Control&rft.au=Albonico%2C+Marco%3BBecker%2C+S%C3%B6ren+L%3BOdermatt%2C+Peter%3BAngheben%2C+Andrea%3BAnselmi%2C+Mariella%3BAmor%2C+Arancha%3BBarda%2C+Beatrice%3BBuonfrate%2C+Dora%3BCooper%2C+Philip%3BG%C3%A9taz%2C+Laurent%3BKeiser%2C+Jennifer%3BKhieu%2C+Virak%3BMontresor%2C+Antonio%3BMu%C3%B1oz%2C+Jos%C3%A9%3BRequena-M%C3%A9ndez%2C+Ana%3BSavioli%2C+Lorenzo%3BSpeare%2C+Richard%3BSteinmann%2C+Peter%3BLieshout%2C+Lisette+van%3BUtzinger%2C+J%C3%BCrg%3BBisoffi%2C+Zeno%3BGroup%2C+StrongNet+Working&rft.aulast=Albonico&rft.aufirst=Marco&rft.date=2016-09-01&rft.volume=10&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pntd.0004898 LA - English DB - ProQuest Central N1 - Name - University of Basel N1 - Copyright - © 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Albonico M, Becker SL, Odermatt P, Angheben A, Anselmi M, Amor A, et al. (2016) StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control. PLoS Negl Trop Dis 10(9): e0004898. doi:10.1371/journal.pntd.0004898 N1 - Last updated - 2016-10-17 N1 - SubjectsTermNotLitGenreText - Switzerland DO - http://dx.doi.org/10.1371/journal.pntd.0004898 ER - TY - JOUR T1 - Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus AN - 1827931751; PQ0003606407 AB - Cells use the post-translational modification ADP-ribosylation to control a host of biological activities. In some pathogenic bacteria, an operon-encoded mono-ADP-ribosylation cycle mediates response to host-induced oxidative stress. In this system, reversible mono ADP-ribosylation of a lipoylated target protein represses oxidative stress response. An NAD super(+)-dependent sirtuin catalyzes the single ADP-ribose (ADPr) addition, while a linked macrodomain-containing protein removes the ADPr. Here we report the crystal structure of the sitruin-linked macrodomain protein from Staphylococcus aureus, SauMacro (also known as SAV0325) to 1.75-Aa resolution. The monomeric SauMacro bears a previously unidentified Zn super(2+)-binding site that putatively aids in substrate recognition and catalysis. An amino-terminal three-helix bundle motif unique to this class of macrodomain proteins provides a structural scaffold for the Zn super(2+) site. Structural features of the enzyme further indicate a cleft proximal to the Zn super(2+) binding site appears well suited for ADPr binding, while a deep hydrophobic channel in the protein core is suitable for binding the lipoate of the lipoylated protein target. JF - Protein Science AU - Appel, CDenise AU - Feld, Geoffrey K AU - Wallace, Bret D AU - Williams, RScott AD - Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, 27709. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1682 EP - 1691 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 9 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - Post-translation KW - Oxidative stress KW - Zinc KW - Sirtuins KW - Crystal structure KW - Enzymes KW - Hydrophobicity KW - Staphylococcus aureus KW - ADP-ribosylation KW - scaffolds KW - Catalysis KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827931751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Structure+of+the+sirtuin-linked+macrodomain+SAV0325+from+Staphylococcus+aureus&rft.au=Appel%2C+CDenise%3BFeld%2C+Geoffrey+K%3BWallace%2C+Bret+D%3BWilliams%2C+RScott&rft.aulast=Appel&rft.aufirst=CDenise&rft.date=2016-09-01&rft.volume=25&rft.issue=9&rft.spage=1682&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/10.1002%2Fpro.2974 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Post-translation; Oxidative stress; Zinc; Crystal structure; Sirtuins; Enzymes; Hydrophobicity; ADP-ribosylation; scaffolds; Catalysis; Staphylococcus aureus DO - http://dx.doi.org/10.1002/pro.2974 ER - TY - JOUR T1 - TECHNICAL RECOMMENDATIONS FOR MONITORING INDIVIDUALS FOR OCCUPATIONAL INTAKES OF RADIONUCLIDES AN - 1827929403; PQ0003673710 AB - The TECHREC project, funded by the European Commission, will provide Technical Recommendations for Monitoring Individuals for Occupational Intakes of Radionuclides. It is expected that the document will be published by the European Commission as a report in its Radiation Protection Series during 2016. The project is coordinated by the European Radiation Dosimetry Group (EURADOS) and is being carried out by members of EURADOS Working Group 7 (Internal Dosimetry). This paper describes the aims and purpose of the Technical Recommendations, and explains how the project is organised. JF - Radiation Protection Dosimetry AU - Etherington, G AU - Berard, P AU - Blanchardon, E AU - Breustedt, B AU - Castellani, C M AU - Vathaire, C Challeton-de AU - Giussani, A AU - Franck, D AU - Lopez, M A AU - Marsh, J W AU - Nosske, D AD - Public Health England (PHE), Centre for Radiation Chemical and Environmental Hazards, Didcot, UK, george.etherington@phe.gov.uk Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 8 EP - 12 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 170 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Toxicology Abstracts; Environment Abstracts KW - Radiation KW - Dosimetry KW - Radioisotopes KW - Radiation dosimetry KW - X 24390:Radioactive Materials KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827929403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=TECHNICAL+RECOMMENDATIONS+FOR+MONITORING+INDIVIDUALS+FOR+OCCUPATIONAL+INTAKES+OF+RADIONUCLIDES&rft.au=Etherington%2C+G%3BBerard%2C+P%3BBlanchardon%2C+E%3BBreustedt%2C+B%3BCastellani%2C+C+M%3BVathaire%2C+C+Challeton-de%3BGiussani%2C+A%3BFranck%2C+D%3BLopez%2C+M+A%3BMarsh%2C+J+W%3BNosske%2C+D&rft.aulast=Etherington&rft.aufirst=G&rft.date=2016-09-01&rft.volume=170&rft.issue=1-4&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncv395 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Radiation; Dosimetry; Radioisotopes; Radiation dosimetry DO - http://dx.doi.org/10.1093/rpd/ncv395 ER - TY - JOUR T1 - CALIBRATION OF THERMOLUMINESCENCE AND FILM DOSEMETERS FOR SKIN DOSES FROM HIGH-ACTIVITY MICROPARTICLES AN - 1827927779; PQ0003673747 AB - The use of EXT-RAD(TM) extremity TLDs and radiochromic film to measure doses from primarily beta-emitting microparticles is discussed. Specific calibration techniques have been developed, using both Monte Carlo modelling and experiments. Results for a super(90) Sr/ super(90) Y microparticle are presented to illustrate the general techniques and to demonstrate reasonable agreement between the dosimetry methods. JF - Radiation Protection Dosimetry AU - Eakins, J S AU - Hager, L G AU - Tanner, R J AD - Public Health England, CRCE, Chilton, Didcot, Oxon OX11 0RQ, UK, jonathan.eakins@phe.gov.uk Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 173 EP - 176 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 170 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Monte Carlo simulation KW - Extremities KW - Skin KW - Radiation KW - Dosimetry KW - Thermoluminescence KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827927779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=CALIBRATION+OF+THERMOLUMINESCENCE+AND+FILM+DOSEMETERS+FOR+SKIN+DOSES+FROM+HIGH-ACTIVITY+MICROPARTICLES&rft.au=Eakins%2C+J+S%3BHager%2C+L+G%3BTanner%2C+R+J&rft.aulast=Eakins&rft.aufirst=J&rft.date=2016-09-01&rft.volume=170&rft.issue=1-4&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncv437 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Extremities; Monte Carlo simulation; Skin; Radiation; Dosimetry; Thermoluminescence DO - http://dx.doi.org/10.1093/rpd/ncv437 ER - TY - JOUR T1 - Deactivation of the left dorsolateral prefrontal cortex in Prader-Willi syndrome after meal consumption AN - 1827927237; PQ0003681734 AB - Background/ Objectives: Prader-Willi syndrome (PWS) is a type of human genetic obesity that may give us information regarding the physiology of non-syndromic obesity. The objective of this study was to investigate the functional correlates of hunger and satiety in individuals with PWS in comparison with healthy controls with obesity, hypothesizing that we would see significant differences in activation in the left dorsolateral prefrontal cortex (DLPFC) based on prior findings.Subjects/ Methods: This study compared the central effects of food consumption in nine individuals with PWS (7 men, 2 women; body fat 35.3 plus or minus 10.0%) and seven controls (7 men; body fat 28.8 plus or minus 7.6%), matched for percentage body fat. H sub(2) super(15)O-PET (positron emission tomography) scans were performed before and after consumption of a standardized liquid meal to obtain quantitative measures of regional cerebral blood flow (rCBF), a marker of neuronal activity. Results: Compared with obese controls, PWS showed altered (P<0.05 family-wise error cluster-level corrected; voxelwise P<0.001) rCBF before and after meal consumption in multiple brain regions. There was a significant differential rCBF response within the left DLPFC after meal ingestion with decreases in DLPFC rCBF in PWS; in controls, DLPFC rCBF tended to remain unchanged. In more liberal analyses (P<0.05 family-wise error cluster-level corrected; voxelwise P<0.005), rCBF of the right orbitofrontal cortex (OFC) increased in PWS and decreased in controls. In PWS, Delta rCBF of the right OFC was associated with changes in appetite ratings. Conclusions: The pathophysiology of eating behavior in PWS is characterized by a paradoxical meal-induced deactivation of the left DLPFC and activation in the right OFC, brain regions implicated in the central regulation of eating behavior. JF - International Journal of Obesity AU - Reinhardt, M AU - Parigi, A D AU - Chen, K AU - Reiman, E M AU - Thiyyagura, P AU - Krakoff, J AU - Hohenadel, M G AU - Le, D S N T AU - Weise, C M AD - Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ, USA; Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1360 EP - 1368 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 40 IS - 9 SN - 0307-0565, 0307-0565 KW - CSA Neurosciences Abstracts; Health & Safety Science Abstracts KW - Hunger KW - Obesity KW - Satiety KW - Physiology KW - Brain KW - Prader-Willi syndrome KW - Ingestion KW - Appetite KW - Blood KW - Food consumption KW - Emissions KW - Positron emission tomography KW - Body fat KW - Standards KW - Deactivation KW - Cortex (prefrontal) KW - Cerebral blood flow KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - N3 11023:Neurogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827927237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Deactivation+of+the+left+dorsolateral+prefrontal+cortex+in+Prader-Willi+syndrome+after+meal+consumption&rft.au=Reinhardt%2C+M%3BParigi%2C+A+D%3BChen%2C+K%3BReiman%2C+E+M%3BThiyyagura%2C+P%3BKrakoff%2C+J%3BHohenadel%2C+M+G%3BLe%2C+D+S+N+T%3BWeise%2C+C+M&rft.aulast=Reinhardt&rft.aufirst=M&rft.date=2016-09-01&rft.volume=40&rft.issue=9&rft.spage=1360&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fijo.2016.75 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Hunger; Food consumption; Obesity; Satiety; Positron emission tomography; Brain; Prader-Willi syndrome; Body fat; Deactivation; Appetite; Cerebral blood flow; Cortex (prefrontal); Blood; Physiology; Emissions; Standards; Ingestion DO - http://dx.doi.org/10.1038/ijo.2016.75 ER - TY - JOUR T1 - Regulation of New Drug Approval in Taiwan AN - 1827925056; PQ0003637382 AB - Taiwan Food and Drug Administration (TFDA) was established in 2010 as the nation's principal consumer product protection agency of food, drugs, medical devices, and cosmetics. By integrating 4 agencies (the Bureau of Food Safety, Bureau of Pharmaceutical Affairs, Bureau of Food and Drug Analysis, and Bureau of Controlled Drugs), TFDA holds the mission of protecting and promoting the public health through regulation modernization to enhance the availability of safe medical products and foods. To address the unmet medical needs and public health, TFDA has utilized regulatory science to evaluate review principles and risk management to properly oversee the overall life cycle of medicinal products. A lot of measures have been accomplished to build an efficient, transparent, and internationally harmonized regulatory system. With the first-in-the-world new drug afatinib approved in Taiwan, TFDA has successfully built up capacity and capability in the review and approval of new drugs. This article summarizes the efforts TFDA has been making in the domain of medicinal product management, highlighting policies and strategies for the future. JF - Therapeutic Innovation & Regulatory Science AU - Yang, Ya-Ting AU - Huang, Hsiau-Wen AU - Chen, Ya-Ting AU - Chiang, Yu-Mei AU - Tzou, Meir-Chyun AD - 1 .Taiwan Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan, pamctzou@fda.gov.tw Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 602 EP - 608 PB - Sage Publications, Inc. VL - 50 IS - 5 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - Taiwan Food and Drug Administration (TFDA) KW - new drug approval KW - good review practice (GRevP) KW - multiple review tracks KW - multiregional clinical trial (MRCT) KW - ICH guidelines KW - Medical equipment KW - Reviews KW - Life cycle KW - Pharmaceuticals KW - Cosmetics KW - Consumers KW - Public health KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827925056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+Innovation+%26+Regulatory+Science&rft.atitle=Regulation+of+New+Drug+Approval+in+Taiwan&rft.au=Yang%2C+Ya-Ting%3BHuang%2C+Hsiau-Wen%3BChen%2C+Ya-Ting%3BChiang%2C+Yu-Mei%3BTzou%2C+Meir-Chyun&rft.aulast=Yang&rft.aufirst=Ya-Ting&rft.date=2016-09-01&rft.volume=50&rft.issue=5&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Therapeutic+Innovation+%26+Regulatory+Science&rft.issn=21684790&rft_id=info:doi/10.1177%2F2168479016640317 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 16 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Medical equipment; Reviews; Pharmaceuticals; Life cycle; Consumers; Cosmetics; Public health DO - http://dx.doi.org/10.1177/2168479016640317 ER - TY - JOUR T1 - Whole-Genome Sequencing for Detecting Antimicrobial Resistance in Nontyphoidal Salmonella AN - 1827904757; PQ0003647309 AB - Laboratory-based in vitro antimicrobial susceptibility testing is the foundation for guiding anti-infective therapy and monitoring antimicrobial resistance trends. We used whole-genome sequencing (WGS) technology to identify known antimicrobial resistance determinants among strains of nontyphoidal Salmonella and correlated these with susceptibility phenotypes to evaluate the utility of WGS for antimicrobial resistance surveillance. Six hundred forty Salmonella of 43 different serotypes were selected from among retail meat and human clinical isolates that were tested for susceptibility to 14 antimicrobials using broth microdilution. The MIC for each drug was used to categorize isolates as susceptible or resistant based on Clinical and Laboratory Standards Institute clinical breakpoints or National Antimicrobial Resistance Monitoring System (NARMS) consensus interpretive criteria. Each isolate was subjected to whole-genome shotgun sequencing, and resistance genes were identified from assembled sequences. A total of 65 unique resistance genes, plus mutations in two structural resistance loci, were identified. There were more unique resistance genes (n = 59) in the 104 human isolates than in the 536 retail meat isolates (n = 36). Overall, resistance genotypes and phenotypes correlated in 99.0% of cases. Correlations approached 100% for most classes of antibiotics but were lower for aminoglycosides and beta-lactams. We report the first finding of extended-spectrum beta -lactamases (ESBLs) (blaCTX-M1 and blaSHV2a) in retail meat isolates of Salmonella in the United States. Whole-genome sequencing is an effective tool for predicting antibiotic resistance in nontyphoidal Salmonella, although the use of more appropriate surveillance breakpoints and increased knowledge of new resistance alleles will further improve correlations. JF - Antimicrobial Agents & Chemotherapy AU - McDermott, Patrick F AU - Tyson, Gregory H AU - Kabera, Claudine AU - Chen, Yuansha AU - Li, Cong AU - Folster, Jason P AU - Ayers, Sherry L AU - Lam, Claudia AU - Tate, Heather P AU - Zhao, Shaohua AD - << + $0, Patrick.McDermott@fda.hhs.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 5515 EP - 5520 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 60 IS - 9 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - beta -Lactamase KW - Serotypes KW - Drug resistance KW - Antibiotics KW - Genotypes KW - Minimum inhibitory concentration KW - Aminoglycoside antibiotics KW - Antimicrobial agents KW - Meat KW - Breakpoints KW - Salmonella KW - Mutation KW - Antibiotic resistance KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827904757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Whole-Genome+Sequencing+for+Detecting+Antimicrobial+Resistance+in+Nontyphoidal+Salmonella&rft.au=McDermott%2C+Patrick+F%3BTyson%2C+Gregory+H%3BKabera%2C+Claudine%3BChen%2C+Yuansha%3BLi%2C+Cong%3BFolster%2C+Jason+P%3BAyers%2C+Sherry+L%3BLam%2C+Claudia%3BTate%2C+Heather+P%3BZhao%2C+Shaohua&rft.aulast=McDermott&rft.aufirst=Patrick&rft.date=2016-09-01&rft.volume=60&rft.issue=9&rft.spage=5515&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01030-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 34 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Serotypes; beta -Lactamase; Drug resistance; Antibiotics; Genotypes; Minimum inhibitory concentration; Aminoglycoside antibiotics; Antimicrobial agents; Meat; Breakpoints; Mutation; Antibiotic resistance; Salmonella DO - http://dx.doi.org/10.1128/AAC.01030-16 ER - TY - JOUR T1 - Pharmacovigilance activities in ASEAN countries AN - 1827904063; PQ0003649857 AB - Purpose This study aimed to explore the current landscape and identify challenges of pharmacovigilance (PV) among Association of Southeast Asian Nations (ASEAN) countries. Methods This cross-sectional survey collected data from May 2014 to December 2015. Questionnaires seeking to collect information on resources, processes, roles and responsibility, and functions of PV systems were sent to relevant persons in the ASEAN countries. Functions of PV centers were measured using the minimum World Health Organization requirements for a functional national PV system. Performances of PV centers were measured by the following: (1) the indicators related to the average number of individual case safety reports (ICSR); (2) presence of signal detection activities and subsequent action; and (3) contribution to the global vigilance database. Results Cambodia, Indonesia, Laos, Malaysia, the Philippines, Singapore, Thailand, and Vietnam completed the survey. PV systems in four surveyed countries (Indonesia, Malaysia, Singapore, and Thailand) achieved all aspects of the World Health Organization minimum requirement for a functional national PV system; the remaining countries were deemed to have unclear communication strategies and/or no official advisory committee. Average numbers of recent ICSR national returns ranged from 7 to 3817 reports/year/million population; three countries (Malaysia, Singapore, and Thailand) demonstrated good performance in reporting system and reported signal detection activities and subsequent actions. All participating countries had submitted ICSRs to the Uppsala Monitoring Center during the survey period (2013-2015). Conclusions Four participating countries had functional PV systems. PV capacity, functionality, and legislative framework varied depending on local healthcare ecosystem networks. Implementing effective communication strategies and/or technical assistance from the advisory committee are needed to strengthen PV in ASEAN. JF - Pharmacoepidemiology and Drug Safety AU - Suwankesawong, Wimon AU - Dhippayom, Teerapon AU - Tan-Koi, Wei-Chuen AU - Kongkaew, Chuenjid AD - Health Product Vigilance Center, Thai Food and Drug Administration, Nonthaburi, Thailand. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1061 EP - 1069 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 9 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts KW - Inventories KW - Databases KW - Data processing KW - Information processing KW - Landscape KW - Communication KW - Vigilance KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827904063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Pharmacovigilance+activities+in+ASEAN+countries&rft.au=Suwankesawong%2C+Wimon%3BDhippayom%2C+Teerapon%3BTan-Koi%2C+Wei-Chuen%3BKongkaew%2C+Chuenjid&rft.aulast=Suwankesawong&rft.aufirst=Wimon&rft.date=2016-09-01&rft.volume=25&rft.issue=9&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Databases; Inventories; Data processing; Information processing; Landscape; Communication; Vigilance DO - http://dx.doi.org/10.1002/pds.4023 ER - TY - JOUR T1 - The ChrSA and HrrSA Two-Component Systems Are Required for Transcriptional Regulation of the hemA Promoter in Corynebacterium diphtheriae AN - 1827901203; PQ0003647445 AB - Corynebacterium diphtheriae utilizes heme and hemoglobin (Hb) as iron sources for growth in low-iron environments. In C. diphtheriae, the two-component signal transduction systems (TCSs) ChrSA and HrrSA are responsive to Hb levels and regulate the transcription of promoters for hmuO, hrtAB, and hemA. ChrSA and HrrSA activate transcription at the hmuO promoter and repress transcription at hemA in an Hb-dependent manner. In this study, we show that HrrSA is the predominant repressor at hemA and that its activity results in transcriptional repression in the presence and absence of Hb, whereas repression of hemA by ChrSA is primarily responsive to Hb. DNA binding studies showed that both ChrA and HrrA bind to the hemA promoter region at virtually identical sequences. ChrA binding was enhanced by phosphorylation, while binding to DNA by HrrA was independent of its phosphorylation state. ChrA and HrrA are phosphorylated in vitro by the sensor kinase ChrS, whereas no kinase activity was observed with HrrS in vitro. Phosphorylated ChrA was not observed in vivo, even in the presence of Hb, which is likely due to the instability of the phosphate moiety on ChrA. However, phosphorylation of HrrA was observed in vivo regardless of the presence of the Hb inducer, and genetic analysis indicates that ChrS is responsible for most of the phosphorylation of HrrA in vivo. Phosphorylation studies strongly suggest that HrrS functions primarily as a phosphatase and has only minimal kinase activity. These findings collectively show a complex mechanism of regulation at the hemA promoter, where both two-component systems act in concert to optimize expression of heme biosynthetic enzymes. IMPORTANCE Understanding the mechanism by which two-component signal transduction systems function to respond to environmental stimuli is critical to the study of bacterial pathogenesis. The current study expands on the previous analyses of the ChrSA and HrrSA TCSs in the human pathogen C. diphtheriae. The findings here underscore the complex interactions between the ChrSA and HrrSA systems in the regulation of the hemA promoter and demonstrate how the two systems complement one another to refine and control transcription in the presence and absence of Hb. JF - Journal of Bacteriology AU - Burgos, Jonathan M AU - Schmitt, Michael P Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 2419 EP - 2430 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 198 IS - 18 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Heme KW - Nucleotide sequence KW - Genetic analysis KW - Transcription KW - Enzymes KW - Corynebacterium diphtheriae KW - Pathogens KW - Hemoglobin KW - Promoters KW - Phosphorylation KW - Phosphate KW - Gene regulation KW - DNA KW - Environmental effects KW - Repressors KW - Iron KW - Gene silencing KW - Signal transduction KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827901203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+ChrSA+and+HrrSA+Two-Component+Systems+Are+Required+for+Transcriptional+Regulation+of+the+hemA+Promoter+in+Corynebacterium+diphtheriae&rft.au=Burgos%2C+Jonathan+M%3BSchmitt%2C+Michael+P&rft.aulast=Burgos&rft.aufirst=Jonathan&rft.date=2016-09-01&rft.volume=198&rft.issue=18&rft.spage=2419&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00339-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 49 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Heme; Nucleotide sequence; Genetic analysis; Enzymes; Transcription; Pathogens; Hemoglobin; Promoters; Phosphate; Phosphorylation; Gene regulation; Environmental effects; DNA; Iron; Repressors; Signal transduction; Gene silencing; Corynebacterium diphtheriae DO - http://dx.doi.org/10.1128/JB.00339-16 ER - TY - JOUR T1 - Design and analysis choices for safety surveillance evaluations need to be tuned to the specifics of the hypothesized drug-outcome association AN - 1827900683; PQ0003649862 AB - Background We reviewed the results of the Observational Medical Outcomes Research Partnership (OMOP) 2010 Experiment in hopes of finding examples where apparently well-designed drug studies repeatedly produce anomalous findings. OMOP had applied thousands of designs and design parameters to 53 drug-outcome pairs across 10 electronic data resources. Our intent was to use this repository to elucidate some sources of error in observational studies. Method From the 2010 OMOP Experiment, we sought drug-outcome-method combinations (DOMCs) that met consensus design criteria, yet repeatedly produced results contrary to expectation. We set aside DOMCs for which we could not agree on the suitability of the designs, then selected for an in-depth scrutiny one drug-outcome pair analyzed by a seemingly plausible methodological approach, whose results consistently disagreed with the a priori expectation. Results The OMOP "all-by-all" assessment of possible DOMCs yielded many combinations that would not be chosen by researchers as actual study options. Among those that passed a first level of scrutiny, two of seven drug-outcome pairs for which there were plausible research designs had anomalous results. The use of benzodiazepines was unexpectedly associated with acute renal failure and upper gastrointestinal bleeding. We chose the latter as an example for in-depth study. The factitious appearance of a bleeding risk may have been partly driven by an excess of procedures on the first day of treatment. A risk window definition that excluded the first day largely removed the spurious association. Conclusion One cause of reproducible "error" may be repeated failure to tie design choices closely enough to the research question at hand. JF - Pharmacoepidemiology and Drug Safety AU - Gruber, Susan AU - Chakravarty, Aloka AU - Heckbert, Susan R AU - Levenson, Mark AU - Martin, David AU - Nelson, Jennifer C AU - Psaty, Bruce M AU - Pinheiro, Simone AU - Reich, Christian G AU - Toh, Sengwee AU - Walker, Alexander M AD - Reagan-Udall Foundation for the FDA, Innovation in Medical Evidence Development and Surveillance, Washington, DC, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 973 EP - 981 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 9 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts KW - Data processing KW - Reviews KW - Benzodiazepine KW - Bleeding KW - Renal failure KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827900683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Design+and+analysis+choices+for+safety+surveillance+evaluations+need+to+be+tuned+to+the+specifics+of+the+hypothesized+drug-outcome+association&rft.au=Gruber%2C+Susan%3BChakravarty%2C+Aloka%3BHeckbert%2C+Susan+R%3BLevenson%2C+Mark%3BMartin%2C+David%3BNelson%2C+Jennifer+C%3BPsaty%2C+Bruce+M%3BPinheiro%2C+Simone%3BReich%2C+Christian+G%3BToh%2C+Sengwee%3BWalker%2C+Alexander+M&rft.aulast=Gruber&rft.aufirst=Susan&rft.date=2016-09-01&rft.volume=25&rft.issue=9&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Data processing; Reviews; Benzodiazepine; Bleeding; Renal failure; Drugs DO - http://dx.doi.org/10.1002/pds.4065 ER - TY - JOUR T1 - Uptake of new drugs in the early post-approval period in the Mini-Sentinel distributed database AN - 1827899616; PQ0003649864 AB - Purpose Several factors limit the statistical power of drug safety surveillance during the early post-approval period, including uptake of the drug and lag in data availability. This study characterized new drug uptake in the Mini-Sentinel Distributed Database and determined statistical power to detect levels of risk in post-launch safety assessments. Methods The cumulative exposure among initiators of 46 new molecular entities approved from 2008 to 2011 was assessed. Using a Poisson estimation method, minimum incidence rate ratios (IRRs) detectable, with 80% power, were calculated under varying background incidence rates. Results Twelve products (26.1%) had more than 15000 new users after 2years. With comparator group incidence rate of 1/1000 person-years, 16 (33.3%) products had enough exposure to detect an IRR of 5 with 24months of data collected that would be available for assessment at 33months post-launch. With an incidence rate of 5/1000 person-years, 23 (50%) products had enough exposure to detect an IRR of greater than or equal to 3 with 2years of data collected. At 33months post-launch, only two (4.3%) of the drugs examined had enough data availability to detect IRR of <2, and eight (17.4%) of <3, with a background rate of 1/1000 person-years. Conclusion This study highlights the importance of drug uptake and data availability in early post-approval drug safety surveillance in Mini-Sentinel. There is limited ability to detect rate ratios below three for events with background rates of 1/1000 person-years or lower. This is largely due to low product uptake. JF - Pharmacoepidemiology and Drug Safety AU - Mott, Katrina AU - Graham, David J AU - Toh, Sengwee AU - Gagne, Joshua J AU - Levenson, Mark AU - Ma, Yong AU - Reichman, Marsha E AD - CDER Office of Surveillance and Epidemiology, U.S. Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1023 EP - 1032 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 9 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts KW - Databases KW - Data processing KW - Statistics KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827899616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Uptake+of+new+drugs+in+the+early+post-approval+period+in+the+Mini-Sentinel+distributed+database&rft.au=Mott%2C+Katrina%3BGraham%2C+David+J%3BToh%2C+Sengwee%3BGagne%2C+Joshua+J%3BLevenson%2C+Mark%3BMa%2C+Yong%3BReichman%2C+Marsha+E&rft.aulast=Mott&rft.aufirst=Katrina&rft.date=2016-09-01&rft.volume=25&rft.issue=9&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Databases; Statistics; Data processing; Drugs DO - http://dx.doi.org/10.1002/pds.4013 ER - TY - JOUR T1 - S06-3Us cohort study of uranium miners on the colorado plateau: what new information can we learn? AN - 1827895304; PQ0003696815 AB - Since the 1950s, the U.S. Public Health Service (and subsequently the National Institute for Occupational Safety and Health) has conducted a cohort study of more than 4000 uranium miners on the Colorado Plateau (CP) in the southwest United States. These miners were obtaining raw uranium to supply the U.S. nuclear weapons industry from the 1940s to the late 1980s. Initially, researchers administered questionnaires and physical examinations among the miners (both white and American Indian), who are a subset of a much larger group of miners employed during the cold war era. Thousands of measurements were made of radon progeny in hundreds of mines over a period of decades. Since the 1970s, the CP cohort has been followed for mortality and morbidity outcomes and smoking assessment. The unique features of the CP cohort include its high doses, extensive dosimetry, near-complete smoking information, and long follow-up. The cohort has contributed extensively to knowledge of lung cancer risk from radon exposure, including understanding of inverse dose-rate effects, changes in risk with time since exposure, and the form of interaction with smoking. As of the last follow-up in 2005, 75% of the cohort was deceased. Despite the anticipation that lung cancer rates would decline in the late follow-up, published findings suggest that attributable risk of lung cancer continues to be high in the cohort, particularly for miners who smoked little or not at all. The form of interaction of radon dose with smoking appears to remain sub-multiplicative but super-additive. Outcomes other than lung cancer, such as idiopathic pulmonary fibrosis, and some forms of renal disease, have shown associations with radon exposure. With a final wave of follow-up, the CP cohort continues to provide key information to support the development of protective standards to minimise lifetime lung cancer risk from occupational radon exposure. JF - Occupational and Environmental Medicine AU - Schubauer-Berigan, Mary AU - Daniels, Robert AD - National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A103 EP - A104 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Fibrosis KW - Occupational safety KW - renal KW - Morbidity KW - Public health KW - Smoking KW - Plateaus KW - Uranium KW - Occupational exposure KW - Lung cancer KW - Inventories KW - Mortality KW - Dosimetry KW - Kidney diseases KW - Lung diseases KW - USA, Colorado Plateau KW - Mines KW - Cancer KW - Radon KW - Health risks KW - Radiation measurements KW - Progeny KW - Mining KW - X 24380:Social Poisons & Drug Abuse KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827895304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=S06-3Us+cohort+study+of+uranium+miners+on+the+colorado+plateau%3A+what+new+information+can+we+learn%3F&rft.au=Schubauer-Berigan%2C+Mary%3BDaniels%2C+Robert&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A103&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.280 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Mortality; Inventories; Fibrosis; Dosimetry; Lung diseases; Kidney diseases; Mines; Radon; Morbidity; Public health; Smoking; Uranium; Progeny; Occupational exposure; Lung cancer; Risk assessment; Occupational safety; renal; Cancer; Health risks; Plateaus; Radiation measurements; Mining; USA, Colorado Plateau DO - http://dx.doi.org/10.1136/oemed-2016-103951.280 ER - TY - JOUR T1 - O13-3Risk assessment: conventional diesel exhaust and lung cancer AN - 1827895173; PQ0003697241 AB - Studies in railroad workers, truck drivers, and miners reveal diesel exhaust to be carcinogenic. Although technology has evolved, a large capacity in the U.S and globally still comprises traditional diesel engine design in transportation, mining, construction and farming. The Diesel Exhaust in Miners Study (DEMS) with an extensive exposure assessment investigated 200 lung cancer deaths in non-coal and non-metal miners. A DEMS dataset was used to calculate the excess lifetime risk for airborne concentrations of respirable elemental carbon (REC). A healthy worker survivor effect and possible confounding by non-diesel power generation and other mining exposures (e.g., explosives) were investigated along with dose-rate effects using Poisson regression methods with high-resolution classification. Lung cancer mortality declined with employment duration and more so when REC and non diesel exposure effects were also estimated, revealing a strong survivor bias. Attenuation of the REC effect was also observed with increasing (lagged) cumulative REC exposure. In underground miners, the excess relative rate of lung cancer mortality was 0.67 (p < 0.0001) for a 10 year exposure to 200 mu g/m3 REC, a typical underground exposure. At occupational REC exposures of 200, 10 and 1 mu g/m3 the excess lifetime risks, respectively, were 119, 43 and 8.7 per thousand. The estimated lifetime risk was greater than some previous estimates not accounting for heathy worker survival bias. This bias was addressed using employment duration and mine above/below ground status. A model-fitted function of cumulative exposure accommodated attenuation of exposure effect. The estimated excess lifetime risks of lung cancer at old diesel REC exposure levels common in occupational groups in the past exceed 5%. JF - Occupational and Environmental Medicine AU - Park, Robert AD - CDC/National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A25 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Survival KW - Employment KW - Workers KW - Carbon KW - Classification KW - Occupational exposure KW - Lung cancer KW - Mortality KW - diesel exhaust* KW - Mines KW - Cancer KW - Exhausts KW - Health risks KW - Electric power generation KW - Diesel KW - Mining KW - Explosives KW - Diesel engines KW - Technology KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827895173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O13-3Risk+assessment%3A+conventional+diesel+exhaust+and+lung+cancer&rft.au=Park%2C+Robert&rft.aulast=Park&rft.aufirst=Robert&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A25&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.68 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mortality; Workers; Carbon; Classification; Survival; Diesel; Explosives; Mines; Occupational exposure; Exhausts; Lung cancer; Risk assessment; diesel exhaust*; Employment; Cancer; Health risks; Electric power generation; Mining; Diesel engines; Technology DO - http://dx.doi.org/10.1136/oemed-2016-103951.68 ER - TY - JOUR T1 - Refinement of the Nanoparticle Emission Assessment Technique into the Nanomaterial Exposure Assessment Technique (NEAT 2.0) AN - 1827895072; PQ0003699924 AB - Engineered nanomaterial emission and exposure characterization studies have been completed at more than 60 different facilities by the National Institute for Occupational Safety and Health (NIOSH). These experiences have provided NIOSH the opportunity to refine an earlier published technique, the Nanoparticle Emission Assessment Technique (NEAT 1.0), into a more comprehensive technique for assessing worker and workplace exposures to engineered nanomaterials. This change is reflected in the new name Nanomaterial Exposure Assessment Technique (NEAT 2.0) which distinguishes it from NEAT 1.0. NEAT 2.0 places a stronger emphasis on time-integrated, filter-based sampling (i.e., elemental mass analysis and particle morphology) in the worker's breathing zone (full shift and task specific) and area samples to develop job exposure matrices. NEAT 2.0 includes a comprehensive assessment of emissions at processes and job tasks, using direct-reading instruments (i.e., particle counters) in data-logging mode to better understand peak emission periods. Evaluation of worker practices, ventilation efficacy, and other engineering exposure control systems and risk management strategies serve to allow for a comprehensive exposure assessment. JF - Journal of Occupational and Environmental Hygiene AU - Eastlake, Adrienne C AU - Beaucham, Catherine AU - Martinez, Kenneth F AU - Dahm, Matthew M AU - Sparks, Christopher AU - Hodson, Laura L AU - Geraci, Charles L AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 708 EP - 717 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 9 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Particle counters KW - Ventilation KW - Respiration KW - Occupational safety KW - Particulates KW - Nanotechnology KW - Risk management KW - Workers KW - Control systems KW - Morphology KW - Emissions KW - Sampling KW - nanoparticles KW - Occupational exposure KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827895072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Refinement+of+the+Nanoparticle+Emission+Assessment+Technique+into+the+Nanomaterial+Exposure+Assessment+Technique+%28NEAT+2.0%29&rft.au=Eastlake%2C+Adrienne+C%3BBeaucham%2C+Catherine%3BMartinez%2C+Kenneth+F%3BDahm%2C+Matthew+M%3BSparks%2C+Christopher%3BHodson%2C+Laura+L%3BGeraci%2C+Charles+L&rft.aulast=Eastlake&rft.aufirst=Adrienne&rft.date=2016-09-01&rft.volume=13&rft.issue=9&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1167278 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Workers; Ventilation; Respiration; Sampling; nanoparticles; Occupational exposure; Environmental hygiene; Risk management; Particle counters; Control systems; Morphology; Occupational safety; Emissions; Particulates; Nanotechnology DO - http://dx.doi.org/10.1080/15459624.2016.1167278 ER - TY - JOUR T1 - O46-2Development of an asthma-specific job exposure matrix for use in the united states AN - 1827891163; PQ0003696763 AB - ObjectivesTo develop an asthma-specific job-exposure matrix (JEM) optimised for the United States (US).MethodsWe started with the asthma-specific N-JEM that was developed for use in northern Europe, and adapted it to reflect workplace conditions in the US and function with the 2010 Standard Occupational Classification (SOC-2010) codes, which are used widely in the US. The N-JEM functions with the 1988 International Standard Classification of Occupations (ISCO-88). Exposures assessed by the N-JEM for ISCO-88 codes were transferred to comparable SOC-2010 codes by using two cross-walks (ISCO-88 to ISCO-08 to SOC-2010). Three experts (two industrial hygienists, one epidemiologist) used the criterion of a high probability of relevant exposure for at least half the workers to delete or confirm exposure status assigned to SOC-2010 occupations, and to identify additional occupations as exposed. The experts worked independently, submitted initial decisions to the study coordinator, and discussed their decisions with the other experts before submitting final decisions. Exposure status in the JEM was based on a majority opinion of the three experts. The resulting alpha version of the new US Asthma-specific JEM (USA-JEM) was applied to current occupations in a cohort of working adults with asthma, exposures were compared to those assessed by the N-JEM, and disagreements were reviewed to consider further modifications to the USA-JEM. ResultsWe made numerous changes to N-JEM exposures assigned to SOC-2010 occupations by cross-walking from the ISCO-88 codes. Comparing exposure assessments from the two JEMs in the same cohort yielded changes for only 15 SOC-2010 detailed occupations. A total of 399 (47.5%) of the 840 SOC-2010 detailed occupations were assessed by the USA-JEM as having probable exposure to at least one of 19 types of work-related asthma agents. ConclusionsThe new USA-JEM could be a useful research tool, but further evaluation of its performance is needed. JF - Occupational and Environmental Medicine AU - Henneberger, Paul AU - Kurth, Laura AU - Doney, Brent AU - Liang, Xiaoming AU - Andersson, Eva AD - CDC/NIOSH, Morgantown, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A87 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Asthma KW - Respiratory diseases KW - International standards KW - USA KW - Classification KW - ANE, Europe KW - Reviews KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827891163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O46-2Development+of+an+asthma-specific+job+exposure+matrix+for+use+in+the+united+states&rft.au=Henneberger%2C+Paul%3BKurth%2C+Laura%3BDoney%2C+Brent%3BLiang%2C+Xiaoming%3BAndersson%2C+Eva&rft.aulast=Henneberger&rft.aufirst=Paul&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A87&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.233 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - International standards; Classification; Reviews; Asthma; Occupational exposure; Respiratory diseases; International standardization; USA; ANE, Europe DO - http://dx.doi.org/10.1136/oemed-2016-103951.233 ER - TY - JOUR T1 - P303Exploring the role of shift work in population-based prospective cohort studies of cancer AN - 1827891012; PQ0003697190 AB - Epidemiologic evidence in humans for a link between shift work and cancer remains inconclusive, despite renewed interest in the subject subsequent to the International Agency for Research on Cancer classification of shift work involving circadian rhythm disruption as a probable carcinogen (group 2A) in 2007.In this study, we reviewed ongoing or recently completed population-based prospective cohort studies of cancer risk factors in adults to evaluate the data collected on occupation, including work schedules and shift work, and the use of these data in the assessment of cancer risk. We also recorded information collected on lifestyle factors that may be associated with cancer or modify risks associated with shift work.Fifty-three cohorts were identified using the National Cancer Institute Cohort Consortium Membership list, pooled studies that used prospective population-based cohorts, and a NIH RePORTER database search. Publications with cancer-specific outcomes were identified using publication lists on cohort websites, searches in journal databases such as PubMed and Scopus, and citation tracking from previously found publications.Questionnaires from 45 cohorts and 3,393 publications that met inclusion criteria were reviewed; principal investigators of each cohort were contacted to corroborate the information abstracted. Twenty-four cohorts collected occupational histories and thirteen have obtained information on shift work, including duration (77%), intensity (46%), and rotating shift schedules (85%). Eighteen publications from six cohorts have investigated associations between shift work and breast, ovarian, uterine, lung, colorectal, prostate, or pancreatic cancers.Relatively few reviewed studies have investigated the relationship between shift work and cancer. We are exploring opportunities to collaborate in studies by analysing existing data or by collecting information on occupation, work schedules, and shift work in studies that are still following up study participants, to further scientific knowledge of the role of shift work in cancer. JF - Occupational and Environmental Medicine AU - Carreon, Tania AU - Robinson, Susan AU - DeBono, Nathaniel AU - MacDonald, Leslie AU - Pinkerton, Lynne AD - National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A223 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - Risk assessment KW - Historical account KW - Carcinogens KW - Working conditions KW - Cancer KW - Shift work KW - Health risks KW - Classification KW - Lung KW - Risk factors KW - Circadian rhythms KW - Data bases KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827891012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=P303Exploring+the+role+of+shift+work+in+population-based+prospective+cohort+studies+of+cancer&rft.au=Carreon%2C+Tania%3BRobinson%2C+Susan%3BDeBono%2C+Nathaniel%3BMacDonald%2C+Leslie%3BPinkerton%2C+Lynne&rft.aulast=Carreon&rft.aufirst=Tania&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A223&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Risk assessment; Historical account; Health risks; Shift work; Classification; Lung; Risk factors; Circadian rhythms; Carcinogens; Data bases; Cancer; Working conditions DO - http://dx.doi.org/10.1136/oemed-2016-103951.618 ER - TY - JOUR T1 - Surface wipe sampling for antineoplastic (chemotherapy) and other hazardous drug residue in healthcare settings: Methodology and recommendations AN - 1827890899; PQ0003699920 AB - Surface wipe sampling for various hazardous agents has been employed in many occupational settings over the years for various reasons such as evaluation of potential dermal exposure and health risk, source determination, quality or cleanliness, compliance, and others. Wipe sampling for surface residue of antineoplastic and other hazardous drugs in healthcare settings is currently the method of choice to determine surface contamination of the workplace with these drugs. The purpose of this article is to review published studies of wipe sampling for antineoplastic and other hazardous drugs, to summarize the methods in use by various organizations and researchers, and to provide some basic guidance for conducting surface wipe sampling for these drugs in healthcare settings. Recommendations on wipe sampling methodology from several government agencies and organizations were reviewed. Published reports on wipe sampling for hazardous drugs in numerous studies were also examined. The critical elements of a wipe sampling program and related limitations were reviewed and summarized. Recommendations and guidance are presented concerning the purposes of wipe sampling for antineoplastic and other hazardous drugs in the healthcare setting, technical factors and variables, sampling strategy, materials required, and limitations. The reporting and interpretation of wipe sample results is also discussed. It is recommended that all healthcare settings where antineoplastic and other hazardous drugs are handled consider wipe sampling as part of a comprehensive hazardous drug "safe handling" program. Although no standards exist for acceptable or allowable surface concentrations for these drugs in the healthcare setting, wipe sampling may be used as a method to characterize potential occupational dermal exposure risk and to evaluate the effectiveness of implemented controls and the overall safety program. A comprehensive safe-handling program for antineoplastic drugs may utilize wipe sampling as a screening tool to evaluate environmental contamination and strive to reduce contamination levels as much as possible, using the industrial hygiene hierarchy of controls. JF - Journal of Occupational and Environmental Hygiene AU - Connor, Thomas H AU - Zock, Matthew D AU - Snow, Amy H AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 658 EP - 667 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Contamination KW - Residues KW - Chemotherapy KW - Compliance KW - Safety KW - Antineoplastic drugs KW - Health risks KW - Health care KW - Risk factors KW - Hygiene KW - Drugs KW - Government agencies KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827890899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Surface+wipe+sampling+for+antineoplastic+%28chemotherapy%29+and+other+hazardous+drug+residue+in+healthcare+settings%3A+Methodology+and+recommendations&rft.au=Connor%2C+Thomas+H%3BZock%2C+Matthew+D%3BSnow%2C+Amy+H&rft.aulast=Connor&rft.aufirst=Thomas&rft.date=2016-09-01&rft.volume=13&rft.issue=9&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1165912 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Health risks; Residues; Contamination; Health care; Chemotherapy; Risk factors; Safety; Compliance; Antineoplastic drugs; Hygiene; Drugs; Government agencies DO - http://dx.doi.org/10.1080/15459624.2016.1165912 ER - TY - JOUR T1 - O41-1Is beryllium-induced lung cancer caused only by soluble forms and high exposure levels? AN - 1827889805; PQ0003696740 AB - The International Agency for Research on Cancer has deemed beryllium a Group 1 lung carcinogen, based in part on findings from a pooled cohort of U.S. beryllium processing workers. The U.S. Occupational Safety and Health Administration (OSHA) recently proposed a tenfold-decreased permissible exposure limit for beryllium, based partly on estimates of lung cancer risk from recent follow-up of this pooled cohort (the only cohort available with quantitative exposure information). Criticisms in the literature and public comments hypothesise that workers hired after 1954 (when exposures were lower) or exposed only to insoluble forms of beryllium do not exhibit increased risk of lung cancer. We evaluated this hypothesis by conducting Cox proportional hazards regression analyses in age-based risk sets within two (of three) plants in the pooled cohort. 98% of workers at these plants were hired 1955-1969. We used categorical and power models to evaluate exposure-response patterns for mean and cumulative beryllium exposure in the two-plant cohort, comparing findings to published estimates from the full pooled cohort. We also evaluated the distribution of exposure-years in each cohort by solubility class (soluble, insoluble, mixed). Mean beryllium exposure averaged <2 mu g/m3 and the predominant form was insoluble, among the two-plant cohort. We observed 75 lung cancer cases (through 2005). Adjusting for confounders related to smoking and the healthy worker effect, we observed a monotonic increase in lung cancer mortality across exposure categories. The exposure-response coefficients (per unit of exposure) were 0.242 (p = 0.087) for mean exposure and 0.151 (p = 0.049) for cumulative exposure, compared to 0.155 and 0.094 (respectively) in the full cohort. The low exposure levels at these two plants and the predominance of insoluble beryllium suggest that the overall pooled cohort findings upon which OSHA's lung cancer risk assessment is based are highly relevant for current workers exposed to all forms of beryllium. JF - Occupational and Environmental Medicine AU - Schubauer-Berigan, Mary AU - Couch, James AU - Deddens, James AD - National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A79 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Safety regulations KW - Occupational safety KW - Carcinogens KW - Workers KW - Smoking KW - Dose-response effects KW - Regression analysis KW - Occupational exposure KW - Lung cancer KW - Mortality KW - Federal regulations KW - Solubility KW - Cancer KW - Health risks KW - Beryllium KW - X 24380:Social Poisons & Drug Abuse KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827889805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O41-1Is+beryllium-induced+lung+cancer+caused+only+by+soluble+forms+and+high+exposure+levels%3F&rft.au=Schubauer-Berigan%2C+Mary%3BCouch%2C+James%3BDeddens%2C+James&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A79&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.212 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Risk assessment; Smoking; Mortality; Workers; Solubility; Dose-response effects; Beryllium; Regression analysis; Carcinogens; Occupational exposure; Lung cancer; Federal regulations; Safety regulations; Occupational safety; Cancer; Health risks DO - http://dx.doi.org/10.1136/oemed-2016-103951.212 ER - TY - JOUR T1 - Vaginal progesterone decreases preterm birth less than or equal to 34weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study AN - 1827887866; PQ0003650973 AB - Objective To evaluate the efficacy of vaginal progesterone administration for preventing preterm birth and perinatal morbidity and mortality in asymptomatic women with a singleton gestation and a mid-trimester sonographic cervical length (CL) less than or equal to 25mm. Methods This was an updated systematic review and meta-analysis of randomized controlled trials comparing the use of vaginal progesterone to placebo/no treatment in women with a singleton gestation and a mid-trimester sonographic CL less than or equal to 25mm. Electronic databases, from their inception to May 2016, bibliographies and conference proceedings were searched. The primary outcome measure was preterm birth less than or equal to 34weeks of gestation or fetal death. Two reviewers independently selected studies, assessed the risk of bias and extracted the data. Pooled relative risks (RRs) with 95% confidence intervals (CI) were calculated. Results Five trials involving 974 women were included. A meta-analysis, including data from the OPPTIMUM study, showed that vaginal progesterone significantly decreased the risk of preterm birth less than or equal to 34weeks of gestation or fetal death compared to placebo (18.1% vs 27.5%; RR, 0.66 (95%CI, 0.52-0.83); P =0.0005; five studies; 974 women). Meta-analyses of data from four trials (723 women) showed that vaginal progesterone administration was associated with a statistically significant reduction in the risk of preterm birth occurring at <28 to<36 gestational weeks (RRs from 0.51 to 0.79), respiratory distress syndrome (RR, 0.47 (95%CI, 0.27-0.81)), composite neonatal morbidity and mortality (RR, 0.59 (95%CI, 0.38-0.91)), birth weight<1500g (RR, 0.52 (95%CI, 0.34-0.81)) and admission to the neonatal intensive care unit (RR, 0.67 (95%CI, 0.50-0.91)). There were no significant differences in neurodevelopmental outcomes at 2years of age between the vaginal progesterone and placebo groups. Conclusion This updated systematic review and meta-analysis reaffirms that vaginal progesterone reduces the risk of preterm birth and neonatal morbidity and mortality in women with a singleton gestation and a mid-trimester CL less than or equal to 25mm, without any deleterious effects on neurodevelopmental outcome. Clinicians should continue to perform universal transvaginal CL screening at 18-24weeks of gestation in women with a singleton gestation and to offer vaginal progesterone to those with a CL less than or equal to 25mm. This article has been selected for Journal Club. Click here to view slides and discussion points. JF - Ultrasound in Obstetrics and Gynecology AU - Romero, R AU - Nicolaides, KH AU - Conde-Agudelo, A AU - O'Brien, J M AU - Cetingoz, E AU - Da Fonseca, E AU - Creasy, G W AU - Hassan, S S AD - Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 308 EP - 317 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 48 IS - 3 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Mortality KW - Age KW - Data processing KW - Gynecology KW - Progesterone KW - Statistical analysis KW - Fetuses KW - Morbidity KW - Pregnancy KW - Intensive care units KW - Bibliographies KW - Reviews KW - Vagina KW - Gestation KW - Neonates KW - Cervix KW - Obstetrics KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827887866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Vaginal+progesterone+decreases+preterm+birth+less+than+or+equal+to+34weeks+of+gestation+in+women+with+a+singleton+pregnancy+and+a+short+cervix%3A+an+updated+meta-analysis+including+data+from+the+OPPTIMUM+study&rft.au=Romero%2C+R%3BNicolaides%2C+KH%3BConde-Agudelo%2C+A%3BO%27Brien%2C+J+M%3BCetingoz%2C+E%3BDa+Fonseca%2C+E%3BCreasy%2C+G+W%3BHassan%2C+S+S&rft.aulast=Romero&rft.aufirst=R&rft.date=2016-09-01&rft.volume=48&rft.issue=3&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.15953 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Age; Data processing; Progesterone; Gynecology; Statistical analysis; Morbidity; Fetuses; Pregnancy; Intensive care units; Bibliographies; Reviews; Gestation; Vagina; Neonates; Cervix; Ultrasound; Obstetrics DO - http://dx.doi.org/10.1002/uog.15953 ER - TY - JOUR T1 - O47-5Association of metrics of peak exposure with beryllium sensitisation AN - 1827886466; PQ0003696773 AB - Interday or intraday high-intensity exposures (i.e., exposure peaks) may be more relevant for initiating beryllium sensitisation (BeS); such exposures may exceed a threshold necessary to activate the immune response. This study evaluated the relationships of exposure metrics reflecting normal process variation and upset conditions with the prevalence of BeS.In a study of workers employed from 1994-1999 at a primary beryllium manufacturing facility, exposure metrics were developed using personal full-shift measurement, 15 minutes to 24 hour process-specific area measurements, and process-upset information gleaned from historical reports. Quantitative intensity metrics included highest-ever job-specific average, maximum, 95th percentile, upper tolerance limit (UTL), exceedance fractions (>0.2 and >2 mu g/m3), and the product of the geometric mean and geometric standard deviation (GMxGSD). Qualitative metrics included professional judgment of process-upsets (PJPU), and number of process-upset events (e.g., power outage). Relationships among these metrics were evaluated using Spearman correlation and their association with BeS was evaluated using logistic regression with splined and log-transformed exposures.As anticipated, a high degree of correlation existed among metrics within full-shift measurements (rS: 0.57-0.99) and task/process measurements (rS: 0.56-0.96), and moderate correlation across the two measurement types (rS: 0.48-0.79). Most of these metrics were associated with BeS in logistic models of log-transformed exposures. In splined models, non-linear associations were observed with average, 95th percentile, UTL, and exceedance fraction > 2 mu g/m3 from the personal samples. Strong associations with BeS were observed for GMxGSD (OR = 1.8 and 3.6) and PJPU (OR = 8.3 and 8.5) for medium and high categories compared to low category. Professional judgments regarding process-upset potential and the combined GMxGSD were valuable in predicting BeS; each may reflect a different aspect of interday and intraday exposure peaks. Non-linear associations were possibly due to confounding by chemical form and/or skin exposure, use of respiratory protection, presence of a threshold and/or by genetic susceptibility. JF - Occupational and Environmental Medicine AU - Virji, Mohammed Abbas AU - Schuler, Christine AU - Stanton, Marcia AU - Kent, Michael AU - Stefaniak, Alexandr AD - NIOSH, Morgantown, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A90 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Manufacturing industry KW - Skin KW - Electricity KW - Models KW - Standard deviation KW - Information processing KW - Beryllium KW - Immune response KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827886466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O47-5Association+of+metrics+of+peak+exposure+with+beryllium+sensitisation&rft.au=Virji%2C+Mohammed+Abbas%3BSchuler%2C+Christine%3BStanton%2C+Marcia%3BKent%2C+Michael%3BStefaniak%2C+Alexandr&rft.aulast=Virji&rft.aufirst=Mohammed&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A90&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.242 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Standard deviation; Skin; Information processing; Beryllium; Immune response; Occupational exposure; Models; Manufacturing industry; Historical account; Electricity DO - http://dx.doi.org/10.1136/oemed-2016-103951.242 ER - TY - JOUR T1 - O13-1An exploratory risk assessment for metalworking fluids (MWFS) AN - 1827885773; PQ0003697236 AB - MWF mixtures vary across manufacturing process, facilities, enterprises and over time. The routes of exposure are dermal in liquid phase, and inhalation as dusts, mists and vapours. The challenge is to generalise from specific worker populations observed over many decades and from animal studies limited to few priority components. Cancer risks have been observed in both hazard identification and exposure-response studies. Respiratory disorders and performance deficits are other health effects of MWFs appearing as increased morbidity and mortality or reduced pulmonary function, as well as immune-mediated disorders: adult-onset asthma and hypersensitivity pneumonitis (HP). Dermatitis has been a constant associate of MWFs for more than two centuries. The goal here was to explore the development of a generic summary of MWF effects to determine exposure levels conferring an acceptable low level of risk in most metalworking environments. Only total gravimetric measures of airborne dusts or mists were considered, usually with restriction to the respirable fraction. Aggregate cancer excess risk was estimated from the few studies with adequate retrospective exposure assessments and work history. Lifetime risk was calculated. Annual proportional loss of respiratory capacity was evaluated, using a benchmark dose procedure. Incidence of asthma and hypersensitivity pneumonitis (HP) was examined as were aggregate symptoms focusing largely on respiratory complaints. For MWF exposure to 0.1 mg/m3 over 45 yr, the lifetime risk of attributable cancer was about 3.5% and attributable respiratory impairment would occur in 4.5% of workers. Lifetime risk of asthma or HP (under outbreak conditions) was 80% at 0.1 mg/m3. After 45 yr at 0.1 mg/m3 MWF, excess prevalence of primarily respiratory symptoms would be 9 percent based on published studies, and 20 percent from NIOSH investigations. JF - Occupational and Environmental Medicine AU - Park, Robert AD - CDC/National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A25 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Inhalation KW - Respiratory diseases KW - Morbidity KW - Dust KW - Workers KW - Hypersensitivity KW - Dose-response effects KW - Risk factors KW - Respiratory function KW - Occupational exposure KW - Dermatitis KW - Mortality KW - Skin KW - Asthma KW - Cancer KW - Health risks KW - Lung KW - Priorities KW - Benchmarks KW - Alveolitis KW - X 24360:Metals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827885773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O13-1An+exploratory+risk+assessment+for+metalworking+fluids+%28MWFS%29&rft.au=Park%2C+Robert&rft.aulast=Park&rft.aufirst=Robert&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A25&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.66 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Inhalation; Risk assessment; Mortality; Skin; Asthma; Cancer; Dust; Morbidity; Workers; Lung; Risk factors; Dose-response effects; Alveolitis; Occupational exposure; Dermatitis; Respiratory diseases; Health risks; Hypersensitivity; Priorities; Respiratory function; Benchmarks DO - http://dx.doi.org/10.1136/oemed-2016-103951.66 ER - TY - JOUR T1 - Effective dust control systems on concrete dowel drilling machinery AN - 1827885738; PQ0003699927 AB - Rotary-type percussion dowel drilling machines, which drill horizontal holes in concrete pavement, have been documented to produce respirable crystalline silica concentrations above recommended exposure criteria. This places operators at potential risk for developing health effects from exposure. United States manufacturers of these machines offer optional dust control systems. The effectiveness of the dust control systems to reduce respirable dust concentrations on two types of drilling machines was evaluated under controlled conditions with the machines operating inside large tent structures in an effort to eliminate secondary exposure sources not related to the dowel-drilling operation. Area air samples were collected at breathing zone height at three locations around each machine. Through equal numbers of sampling rounds with the control systems randomly selected to be on or off, the control systems were found to significantly reduce respirable dust concentrations from a geometric mean of 54 mg per cubic meter to 3.0 mg per cubic meter on one machine and 57 mg per cubic meter to 5.3 mg per cubic meter on the other machine. This research shows that the dust control systems can dramatically reduce respirable dust concentrations by over 90% under controlled conditions. However, these systems need to be evaluated under actual work conditions to determine their effectiveness in reducing worker exposures to crystalline silica below hazardous levels. JF - Journal of Occupational and Environmental Hygiene AU - Echt, Alan S AU - Sanderson, Wayne T AU - Mead, Kenneth R AU - Feng, HAmy AU - Farwick, Daniel R AU - Farwick, Dawn Ramsey AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 718 EP - 724 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - USA KW - Silica KW - Control systems KW - Machinery KW - Air sampling KW - Dust KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827885738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Effective+dust+control+systems+on+concrete+dowel+drilling+machinery&rft.au=Echt%2C+Alan+S%3BSanderson%2C+Wayne+T%3BMead%2C+Kenneth+R%3BFeng%2C+HAmy%3BFarwick%2C+Daniel+R%3BFarwick%2C+Dawn+Ramsey&rft.aulast=Echt&rft.aufirst=Alan&rft.date=2016-09-01&rft.volume=13&rft.issue=9&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1177644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Silica; Control systems; Machinery; Air sampling; Occupational exposure; Dust; USA DO - http://dx.doi.org/10.1080/15459624.2016.1177644 ER - TY - JOUR T1 - P026Using cancer registry data and job exposure matrices for occupational cancer surveillance AN - 1827885614; PQ0003696894 AB - Cancer is the second leading cause of death in the US, accounting for 1 out of 4 deaths, and cancer incidence is over two-fold higher compared to cancer mortality. Occupational exposures are an important cancer risk factor, exceeded only by tobacco consumption, and infectious disease. However, it is estimated that only less than 2% of chemicals in commerce have been tested for carcinogenicity. In addition, many workers are exposed to multiple carcinogens at low levels, and the effect of exposure to these mixtures is unknown. Therefore, despite progress in understanding cancer aetiology, much is still unknown about the role played by work and workplace exposures. Without a better understanding of the occupational role in cancer aetiology, targeting public health interventions is fraught with difficulty. In October 2015 NIOSH began developing a multistate population-based occupational cancer surveillance system utilising cancer registry data from six states (California, Iowa, Kentucky, Massachusetts, New Hampshire, and Texas), and creating job exposure matrices (JEMs) for use with the cancer registry data. The occupational cancer surveillance system will be used to identify occupational cancer risks, and to explore dose-response relationships using JEMs. It builds upon the successes of a NIOSH pilot initiative begun in 2007 with the California Cancer Registry. By the end of the project in 2019, it is estimated that 3.8 million cancer cases from the six participating states will be available for analysis. For each of these cases, NIOSH will have information on their longest held job (i.e. industry and occupation titles and corresponding codes, and JEM scores for at least four exposures). This presentation will provide the latest findings from the NIOSH occupational cancer surveillance project. JF - Occupational and Environmental Medicine AU - Calvert, Geoffrey AD - NIOSH/CDC, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A128 EP - A129 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Pilots KW - Intervention KW - Carcinogens KW - Public health KW - ASW, USA, Texas KW - Infectious diseases KW - Carcinogenicity KW - INE, USA, California KW - Dose-response effects KW - Risk factors KW - Tobacco KW - USA, New Hampshire KW - Occupational exposure KW - Mortality KW - USA, Massachusetts KW - Data processing KW - Cancer KW - Health risks KW - USA, Kentucky KW - USA, Iowa KW - X 24380:Social Poisons & Drug Abuse KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827885614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=P026Using+cancer+registry+data+and+job+exposure+matrices+for+occupational+cancer+surveillance&rft.au=Calvert%2C+Geoffrey&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A128&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.351 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Infectious diseases; Carcinogenicity; Risk factors; Dose-response effects; Tobacco; Carcinogens; Occupational exposure; Cancer; Public health; Chemicals; Pilots; Intervention; Health risks; ASW, USA, Texas; USA, Massachusetts; USA, Kentucky; USA, Iowa; INE, USA, California; USA, New Hampshire DO - http://dx.doi.org/10.1136/oemed-2016-103951.351 ER - TY - JOUR T1 - DNA-PK Deficiency in Alzheimer's Disease. AN - 1826718927; 27376156 AB - Alzheimer's disease (AD) is characterized by neuronal death with an accumulaton of intra-cellular neurofibrillary tangles (NFT) and extracellular amyloid plaques. Reduced DNA repair ability has been reported in AD brains. In neurons, the predominant mechanism to repair double-strand DNA breaks (DSB) is non-homologous end joining (NHEJ) that requires DNA-dependent protein kinase (DNA-PK) activity. DNA-PK is a holoenzyme comprising the p460 kD DNA-PK catalytic subunit (DNA-PKcs) and its activator Ku, a heterodimer of p86 (Ku80) and p70 (Ku70) subunits. Upon binding to double-stranded DNA ends, Ku recruits DNA-PKcs to process NHEJ. In AD brains, reduced NHEJ activity as well as DNA-PKcs and Ku protein levels have been shown. Normal aging brains also show a reduction in both DNA-PKcs and Ku levels questioning a direct link between NHEJ ability and AD, and suggesting additional players/events in AD pathogenesis. Deficiency of Ku80, a somatostatin receptor, can disrupt somatostatin signaling thus inducing amyloid beta (Aβ) generation, which in turn can potentiate DNA-PKcs degradation and consequently loss of NHEJ activity, an additional step negatively affecting DSB repair. Trigger of these two different pathways culminating in genome instability may differentiate the outcomes between AD and normal aging. JF - Journal of neurology & neuromedicine AU - Kanungo, Jyotshna AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 17 EP - 22 VL - 1 IS - 3 KW - DNA Break KW - Ku KW - Alzheimer’s Disease KW - DNA-PK KW - NHEJ UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826718927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurology+%26+neuromedicine&rft.atitle=DNA-PK+Deficiency+in+Alzheimer%27s+Disease.&rft.au=Kanungo%2C+Jyotshna&rft.aulast=Kanungo&rft.aufirst=Jyotshna&rft.date=2016-09-01&rft.volume=1&rft.issue=3&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurology+%26+neuromedicine&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Getting the most out of PubChem for virtual screening. AN - 1825220259; 27454129 AB - With the emergence of the 'big data' era, the biomedical research community has great interest in exploiting publicly available chemical information for drug discovery. PubChem is an example of public databases that provide a large amount of chemical information free of charge. This article provides an overview of how PubChem's data, tools, and services can be used for virtual screening and reviews recent publications that discuss important aspects of exploiting PubChem for drug discovery. PubChem offers comprehensive chemical information useful for drug discovery. It also provides multiple programmatic access routes, which are essential to build automated virtual screening pipelines that exploit PubChem data. In addition, PubChemRDF allows users to download PubChem data and load them into a local computing facility, facilitating data integration between PubChem and other resources. PubChem resources have been used in many studies for developing bioactivity and toxicity prediction models, discovering polypharmacologic (multi-target) ligands, and identifying new macromolecule targets of compounds (for drug-repurposing or off-target side effect prediction). These studies demonstrate the usefulness of PubChem as a key resource for computer-aided drug discovery and related area. JF - Expert opinion on drug discovery AU - Kim, Sunghwan AD - a National Center for Biotechnology Information, National Library of Medicine , National Institutes of Health , Department of Health and Human Services, Bethesda , MD , USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 843 EP - 855 VL - 11 IS - 9 KW - Index Medicus KW - data mining KW - biological assay KW - cheminformatics KW - polypharmacology KW - computer-aided drug discovery KW - computational toxicology KW - PubChem KW - quantitative structure-activity relationship (QSAR) KW - database KW - virtual screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825220259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+discovery&rft.atitle=Getting+the+most+out+of+PubChem+for+virtual+screening.&rft.au=Kim%2C+Sunghwan&rft.aulast=Kim&rft.aufirst=Sunghwan&rft.date=2016-09-01&rft.volume=11&rft.issue=9&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+discovery&rft.issn=1746-045X&rft_id=info:doi/10.1080%2F17460441.2016.1216967 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/17460441.2016.1216967 ER - TY - JOUR T1 - Observation-based blended projections from ensembles of regional climate models AN - 1819147407; PQ0003618172 AB - We consider the problem of projecting future climate from ensembles of regional climate model (RCM) simulations using results from the North American Regional Climate Change Assessment Program (NARCCAP). To this end, we develop a hierarchical Bayesian space-time model that quantifies the discrepancies between different members of an ensemble of RCMs corresponding to present day conditions, and observational records. Discrepancies are then propagated into the future to obtain high resolution blended projections of 21st century climate. In addition to blended projections, the proposed method provides location-dependent comparisons between the different simulations by estimating the different modes of spatial variability, and using the climate model-specific coefficients of the spatial factors for comparisons. The approach has the flexibility to provide projections at customizable scales of potential interest to stakeholders while accounting for the uncertainties associated with projections at these scales based on a comprehensive statistical framework. We demonstrate the methodology with simulations from the Weather Research & Forecasting regional model (WRF) using three different boundary conditions. We use simulations for two time periods: current climate conditions, covering 1971 to 2000, and future climate conditions under the Special Report on Emissions Scenarios (SRES) A2 emissions scenario, covering 2041 to 2070. We investigate and project yearly mean summer and winter temperatures for a domain in the South West of the United States. JF - Climatic Change AU - Salazar, Esther AU - Hammerling, Dorit AU - Wang, Xia AU - Sanso, Bruno AU - Finley, Andrew O AU - Mearns, Linda O AD - U.S. Food and Drug Administration, Center for Tobacco Products, Silver Spring, MD, USA, bruno@ams.ucsc.edu Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 55 EP - 69 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 138 IS - 1-2 SN - 0165-0009, 0165-0009 KW - Pollution Abstracts; Environment Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; Water Resources Abstracts; Meteorological & Geoastrophysical Abstracts KW - Prediction KW - Variability KW - Climate change KW - Summer KW - Regional climates KW - Boundary conditions KW - Winter temperatures KW - Winter KW - Spatial variations KW - Emissions KW - Forecasting KW - Regional climate models KW - Weather forecasting KW - Spatial variability KW - Modelling KW - Weather KW - Climate models KW - Simulation Analysis KW - Boundary Conditions KW - Climates KW - Climate KW - Temperature KW - Simulation KW - Methodology KW - USA KW - Air pollution forecasting KW - Numerical simulations KW - Regional-scale models KW - Future climates KW - Q5 08503:Characteristics, behavior and fate KW - P 0000:AIR POLLUTION KW - M2 551.583:Variations (551.583) KW - SW 0810:General KW - O 4080:Pollution - Control and Prevention KW - ENA 20:Weather Modification & Geophysical Change UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819147407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Climatic+Change&rft.atitle=Observation-based+blended+projections+from+ensembles+of+regional+climate+models&rft.au=Salazar%2C+Esther%3BHammerling%2C+Dorit%3BWang%2C+Xia%3BSanso%2C+Bruno%3BFinley%2C+Andrew+O%3BMearns%2C+Linda+O&rft.aulast=Salazar&rft.aufirst=Esther&rft.date=2016-09-01&rft.volume=138&rft.issue=1-2&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Climatic+Change&rft.issn=01650009&rft_id=info:doi/10.1007%2Fs10584-016-1722-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Number of references - 26 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Spatial variations; Prediction; Climate change; Climate; Weather forecasting; Methodology; Modelling; Climate models; Numerical simulations; Regional-scale models; Regional climates; Regional climate models; Winter temperatures; Boundary conditions; Spatial variability; Future climates; Weather; Air pollution forecasting; Temperature; Emissions; Simulation; Summer; Winter; Variability; Boundary Conditions; Simulation Analysis; Climates; Forecasting; USA DO - http://dx.doi.org/10.1007/s10584-016-1722-1 ER - TY - JOUR T1 - Ensemble survival trees for identifying subpopulations in personalized medicine. AN - 1817027829; 27073016 AB - Recently, personalized medicine has received great attention to improve safety and effectiveness in drug development. Personalized medicine aims to provide medical treatment that is tailored to the patient's characteristics such as genomic biomarkers, disease history, etc., so that the benefit of treatment can be optimized. Subpopulations identification is to divide patients into several different subgroups where each subgroup corresponds to an optimal treatment. For two subgroups, traditionally the multivariate Cox proportional hazards model is fitted and used to calculate the risk score when outcome is survival time endpoint. Median is commonly chosen as the cutoff value to separate patients. However, using median as the cutoff value is quite subjective and sometimes may be inappropriate in situations where data are imbalanced. Here, we propose a novel tree-based method that adopts the algorithm of relative risk trees to identify subgroup patients. After growing a relative risk tree, we apply k-means clustering to group the terminal nodes based on the averaged covariates. We adopt an ensemble Bagging method to improve the performance of a single tree since it is well known that the performance of a single tree is quite unstable. A simulation study is conducted to compare the performance between our proposed method and the multivariate Cox model. The applications of our proposed method to two public cancer data sets are also conducted for illustration. © Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Biometrical journal. Biometrische Zeitschrift AU - Chen, Yu-Chuan AU - Chen, James J AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. jamesJ.chen@fda.hhs.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1151 EP - 1163 VL - 58 IS - 5 KW - Index Medicus KW - Ensemble method KW - Subgroup identification KW - Cox proportional hazards model KW - Survival trees KW - Personalized medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1817027829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+journal.+Biometrische+Zeitschrift&rft.atitle=Ensemble+survival+trees+for+identifying+subpopulations+in+personalized+medicine.&rft.au=Chen%2C+Yu-Chuan%3BChen%2C+James+J&rft.aulast=Chen&rft.aufirst=Yu-Chuan&rft.date=2016-09-01&rft.volume=58&rft.issue=5&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Biometrical+journal.+Biometrische+Zeitschrift&rft.issn=1521-4036&rft_id=info:doi/10.1002%2Fbimj.201500075 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bimj.201500075 ER - TY - JOUR T1 - Cooking Coal Use and All-Cause and Cause-Specific Mortality in a Prospective Cohort Study of Women in Shanghai, China. AN - 1816630804; 27091488 AB - Nearly 4.3 million deaths worldwide were attributable to exposure to household air pollution in 2012. However, household coal use remains widespread. We investigated the association of cooking coal and all-cause and cause-specific mortality in a prospective cohort of primarily never-smoking women in Shanghai, China. A cohort of 74,941 women were followed from 1996 through 2009 with annual linkage to the Shanghai vital statistics database. Cause-specific mortality was identified through 2009. Use of household coal for cooking was assessed through a residential history questionnaire. Cox proportional hazards models estimated the risk of mortality associated with household coal use. In this cohort, 63% of the women ever used coal (n = 46,287). Compared with never coal use, ever use of coal was associated with mortality from all causes [hazard ratio (HR) = 1.12; 95% confidence interval (CI): 1.05, 1.21], cancer (HR = 1.14; 95% CI: 1.03, 1.27), and ischemic heart disease (overall HR = 1.61; 95% CI: 1.14, 2.27; HR for myocardial infarction specifically = 1.80; 95% CI: 1.16, 2.79). The risk of cardiovascular mortality increased with increasing duration of coal use, compared with the risk in never users. The association between coal use and ischemic heart disease mortality diminished with increasing years since cessation of coal use. Evidence from this study suggests that past use of coal among women in Shanghai is associated with excess all-cause mortality, and from cardiovascular diseases in particular. The decreasing association with cardiovascular mortality as the time since last use of coal increased emphasizes the importance of reducing use of household coal where use is still widespread. Kim C, Seow WJ, Shu XO, Bassig BA, Rothman N, Chen BE, Xiang YB, Hosgood HD III, Ji BT, Hu W, Wen C, Chow WH, Cai Q, Yang G, Gao YT, Zheng W, Lan Q. 2016. Cooking coal use and all-cause and cause-specific mortality in a prospective cohort study of women in Shanghai, China. Environ Health Perspect 124:1384-1389; http://dx.doi.org/10.1289/EHP236. JF - Environmental health perspectives AU - Kim, Christopher AU - Seow, Wei Jie AU - Shu, Xiao-Ou AU - Bassig, Bryan A AU - Rothman, Nathaniel AU - Chen, Bingshu E AU - Xiang, Yong-Bing AU - Hosgood, H Dean AU - Ji, Bu-Tian AU - Hu, Wei AU - Wen, Cuiju AU - Chow, Wong-Ho AU - Cai, Qiuyin AU - Yang, Gong AU - Gao, Yu-Tang AU - Zheng, Wei AU - Lan, Qing AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1384 EP - 1389 VL - 124 IS - 9 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816630804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cooking+Coal+Use+and+All-Cause+and+Cause-Specific+Mortality+in+a+Prospective+Cohort+Study+of+Women+in+Shanghai%2C+China.&rft.au=Kim%2C+Christopher%3BSeow%2C+Wei+Jie%3BShu%2C+Xiao-Ou%3BBassig%2C+Bryan+A%3BRothman%2C+Nathaniel%3BChen%2C+Bingshu+E%3BXiang%2C+Yong-Bing%3BHosgood%2C+H+Dean%3BJi%2C+Bu-Tian%3BHu%2C+Wei%3BWen%2C+Cuiju%3BChow%2C+Wong-Ho%3BCai%2C+Qiuyin%3BYang%2C+Gong%3BGao%2C+Yu-Tang%3BZheng%2C+Wei%3BLan%2C+Qing&rft.aulast=Kim&rft.aufirst=Christopher&rft.date=2016-09-01&rft.volume=124&rft.issue=9&rft.spage=1384&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2FEHP236 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/EHP236 ER - TY - JOUR T1 - Post-9/11 cancer incidence in World Trade Center-exposed New York City firefighters as compared to a pooled cohort of firefighters from San Francisco, Chicago and Philadelphia (9/11/2001-2009). AN - 1816629159; 27582474 AB - BACKGROUND We previously reported a modest excess of cancer in World Trade Center (WTC)-exposed firefighters versus the general population. This study aimed to separate the potential carcinogenic effects of firefighting and WTC exposure by comparing to a cohort of non-WTC-exposed firefighters. METHODS Relative rates (RRs) for all cancers combined and individual cancer subtypes from 9/11/2001 to 12/31/2009 were modeled using Poisson regression comparing 11,457 WTC-exposed firefighters to 8,220 urban non-WTC-exposed firefighters. RESULTS Compared with non-WTC-exposed firefighters, there was no difference in the RR of all cancers combined for WTC-exposed firefighters (RR = 0.96, 95%CI: 0.83-1.12). Thyroid cancer was significantly elevated (RR = 3.82, 95%CI: 1.07-20.81) from 2001 to 2009; this was attenuated (RR = 3.43, 95%CI: 0.94-18.94) and non-significant when controlling for possible surveillance bias. Prostate cancer was elevated during the latter half (2005-2009; RR = 1.38, 95%CI: 1.01-1.88). CONCLUSIONS Further follow-up is needed to assess the relationship between WTC exposure and cancers with longer latency periods. Am. J. Ind. Med. 59:722-730, 2016. © 2016 Wiley Periodicals, Inc. JF - American journal of industrial medicine AU - Moir, William AU - Zeig-Owens, Rachel AU - Daniels, Robert D AU - Hall, Charles B AU - Webber, Mayris P AU - Jaber, Nadia AU - Yiin, James H AU - Schwartz, Theresa AU - Liu, Xiaoxue AU - Vossbrinck, Madeline AU - Kelly, Kerry AU - Prezant, David J AD - Department of Medicine, Montefiore Medical Center, Bronx, New York. ; Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, Ohio. ; Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York. ; Bureau of Health Services, Fire Department of the City of New York, Brooklyn, New York. ; Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 722 EP - 730 VL - 59 IS - 9 KW - Index Medicus KW - firefighters KW - epidemiology KW - World Trade Center (WTC) KW - environmental disaster KW - cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816629159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Post-9%2F11+cancer+incidence+in+World+Trade+Center-exposed+New+York+City+firefighters+as+compared+to+a+pooled+cohort+of+firefighters+from+San+Francisco%2C+Chicago+and+Philadelphia+%289%2F11%2F2001-2009%29.&rft.au=Moir%2C+William%3BZeig-Owens%2C+Rachel%3BDaniels%2C+Robert+D%3BHall%2C+Charles+B%3BWebber%2C+Mayris+P%3BJaber%2C+Nadia%3BYiin%2C+James+H%3BSchwartz%2C+Theresa%3BLiu%2C+Xiaoxue%3BVossbrinck%2C+Madeline%3BKelly%2C+Kerry%3BPrezant%2C+David+J&rft.aulast=Moir&rft.aufirst=William&rft.date=2016-09-01&rft.volume=59&rft.issue=9&rft.spage=722&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.22635 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-01 N1 - Date revised - 2017-02-16 N1 - Last updated - 2017-02-16 DO - http://dx.doi.org/10.1002/ajim.22635 ER - TY - JOUR T1 - Development of a quality instrument for assessing the spontaneous reports of ADR/ADE using Delphi method in China AN - 1815707704; PQ0003588739 AB - The frequently low quality of submitted spontaneous reports is of an increasing concern; to our knowledge, no validated instrument exists for assessing case reports' quality comprehensively enough. This work was conducted to develop such a quality instrument for assessing the spontaneous reports of adverse drug reaction (ADR)/adverse drug event (ADE) in China. Initial evaluation indicators were generated using systematic and literature data analysis. Final indicators and their weights were identified using Delphi method. The final quality instrument was developed by adopting the synthetic scoring method. A consensus was reached after four rounds of Delphi survey. The developed quality instrument consisted of 6 first-rank indicators, 18 second-rank indicators, and 115 third-rank indicators, and each rank indicator has been weighted. It evaluates the quality of spontaneous reports of ADR/ADE comprehensively and quantitatively on six parameters: authenticity, duplication, regulatory, completeness, vigilance level, and reporting time frame. The developed instrument was tested with good reliability and validity, which can be used to comprehensively and quantitatively assess the submitted spontaneous reports of ADR/ADE in China. JF - European Journal of Clinical Pharmacology AU - Chen, Lixun AU - Jiang, Ling AU - Shen, Aizong AU - Wei, Wei AD - Zhejiang Food and Drug Administration, Hangzhou, China, chenlixun@outlook.com Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1135 EP - 1142 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 72 IS - 9 SN - 0031-6970, 0031-6970 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Case reports KW - Vigilance KW - Drugs KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815707704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Pharmacology&rft.atitle=Development+of+a+quality+instrument+for+assessing+the+spontaneous+reports+of+ADR%2FADE+using+Delphi+method+in+China&rft.au=Chen%2C+Lixun%3BJiang%2C+Ling%3BShen%2C+Aizong%3BWei%2C+Wei&rft.aulast=Chen&rft.aufirst=Lixun&rft.date=2016-09-01&rft.volume=72&rft.issue=9&rft.spage=1135&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Pharmacology&rft.issn=00316970&rft_id=info:doi/10.1007%2Fs00228-016-2081-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 22 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Data processing; Case reports; Vigilance; Drugs DO - http://dx.doi.org/10.1007/s00228-016-2081-6 ER - TY - JOUR T1 - Evaluation of sampling methods for toxicological testing of indoor air particulate matter. AN - 1815368857; 27569522 AB - There is a need for toxicity tests capable of recognizing indoor environments with compromised air quality, especially in the context of moisture damage. One of the key issues is sampling, which should both provide meaningful material for analyses and fulfill requirements imposed by practitioners using toxicity tests for health risk assessment. We aimed to evaluate different existing methods of sampling indoor particulate matter (PM) to develop a suitable sampling strategy for a toxicological assay. During three sampling campaigns in moisture-damaged and non-damaged school buildings, we evaluated one passive and three active sampling methods: the Settled Dust Box (SDB), the Button Aerosol Sampler, the Harvard Impactor and the National Institute for Occupational Safety and Health (NIOSH) Bioaerosol Cyclone Sampler. Mouse RAW264.7 macrophages were exposed to particle suspensions and cell metabolic activity (CMA), production of nitric oxide (NO) and tumor necrosis factor (TNFα) were determined after 24 h of exposure. The repeatability of the toxicological analyses was very good for all tested sampler types. Variability within the schools was found to be high especially between different classrooms in the moisture-damaged school. Passively collected settled dust and PM collected actively with the NIOSH Sampler (Stage 1) caused a clear response in exposed cells. The results suggested the higher relative immunotoxicological activity of dust from the moisture-damaged school. The NIOSH Sampler is a promising candidate for the collection of size-fractionated PM to be used in toxicity testing. The applicability of such sampling strategy in grading moisture damage severity in buildings needs to be developed further in a larger cohort of buildings. JF - Inhalation toxicology AU - Tirkkonen, Jenni AU - Täubel, Martin AU - Hirvonen, Maija-Riitta AU - Leppänen, Hanna AU - Lindsley, William G AU - Chen, Bean T AU - Hyvärinen, Anne AU - Huttunen, Kati AD - a Department of Environmental Science , University of Eastern Finland , Kuopio , Finland . ; c National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Morgantown , WV , USA. ; b Department of Health Protection , Living Environment and Health Unit, National Institute for Health and Welfare , Kuopio , Finland , and. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 500 EP - 507 VL - 28 IS - 11 KW - Index Medicus KW - toxicity testing KW - moisture damage KW - particulate matter KW - sampling KW - Indoor air KW - in vitro UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815368857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Evaluation+of+sampling+methods+for+toxicological+testing+of+indoor+air+particulate+matter.&rft.au=Tirkkonen%2C+Jenni%3BT%C3%A4ubel%2C+Martin%3BHirvonen%2C+Maija-Riitta%3BLepp%C3%A4nen%2C+Hanna%3BLindsley%2C+William+G%3BChen%2C+Bean+T%3BHyv%C3%A4rinen%2C+Anne%3BHuttunen%2C+Kati&rft.aulast=Tirkkonen&rft.aufirst=Jenni&rft.date=2016-09-01&rft.volume=28&rft.issue=11&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958378.2016.1210702 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/08958378.2016.1210702 ER - TY - JOUR T1 - A Randomized Controlled Trial of POWER: An Internet-Based HIV Prevention Intervention for Black Bisexual Men AN - 1813587853 AB - POWER is a theory-based, on-line HIV prevention intervention developed specifically for Black men who have sex with men and women (BMSMW), an understudied group significantly impacted by HIV. To test its efficacy, we recruited 224 BMSMW using chain referral methods and randomly assigned 108 to POWER and 103 to a health information comparison condition. Three months after the intervention, participants assigned to POWER had lower odds of reporting any condomless vaginal or condomless anal intercourse (CVAI) compared to those in the comparison group (aOR = 0.49; 95 % CI 0.25-0.98; p = 0.044). The intervention was associated with significantly lower odds of condomless anal intercourse with male partners (aOR = 0.55; 95 % CI 0.34-0.91; p = 0.020) but not with female partners and serodiscordant sex with male partners but not with female partners. Future studies are needed to replicate these findings in larger and more diverse samples of BMSMW and to understand the underlying mechanisms through which intervention efficacy was achieved. JF - AIDS and Behavior AU - Fernandez, M Isabel AU - Hosek, Sybil G AU - Hotton, Anna L AU - Gaylord, Sanford E AU - Hernandez, Nilda AU - Alfonso, Sarah V AU - Joseph, Heather AD - Behavioral Health Promotion Program, College of Osteopathic Medicine, Nova Southeastern University, Miami, FL, USA ; Department of Psychiatry, Stroger Hospital of Cook County, Chicago, IL, USA ; Division of Epidemiology and Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, IL, USA ; Regional Resource Network Program, US Department of Health and Human Services, Region V, Chicago, IL, USA ; Centers for Disease Control and Prevention, Atlanta, GA, USA ; Behavioral Health Promotion Program, College of Osteopathic Medicine, Nova Southeastern University, Miami, FL, USA Y1 - 2016/09// PY - 2016 DA - Sep 2016 SP - 1951 EP - 1960 CY - New York PB - Springer Science & Business Media VL - 20 IS - 9 SN - 1090-7165 KW - Psychology KW - BMSMW KW - HIV prevention KW - Interventions KW - Sexual behavior KW - Acquired Immune Deficiency Syndrome KW - Intervention KW - Prevention KW - Homosexuality KW - Methodology (Data Collection) KW - Sexual Intercourse KW - Bisexuality KW - Internet KW - Power KW - 6129:addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1813587853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=A+Randomized+Controlled+Trial+of+POWER%3A+An+Internet-Based+HIV+Prevention+Intervention+for+Black+Bisexual+Men&rft.au=Fernandez%2C+M+Isabel%3BHosek%2C+Sybil+G%3BHotton%2C+Anna+L%3BGaylord%2C+Sanford+E%3BHernandez%2C+Nilda%3BAlfonso%2C+Sarah+V%3BJoseph%2C+Heather&rft.aulast=Fernandez&rft.aufirst=M&rft.date=2016-09-01&rft.volume=20&rft.issue=9&rft.spage=1951&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-016-1403-0 LA - English DB - Social Services Abstracts N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-12-07 DO - http://dx.doi.org/10.1007/s10461-016-1403-0 ER - TY - JOUR T1 - A Model to predict severity of drug-induced liver injury in humans. AN - 1812881614; 27302180 AB - Drug-induced liver injury (DILI) is a major public health concern, and improving its prediction remains an unmet challenge. Recently, we reported the Rule-of-2 (RO2) and found lipophilicity (logP ≥3) and daily dose ≥100 mg of oral medications to be associated with significant risk for DILI; however, the RO2 failed to estimate grades of DILI severity. In an effort to develop a quantitative metrics, we analyzed the association of daily dose, logP, and formation of reactive metabolites (RM) in a large set of Food and Drug Administration-approved oral medications and found factoring RM into the RO2 to highly improve DILI prediction. Based on these parameters and by considering n = 354 drugs, an algorithm to assign a DILI score was developed. In univariate and multivariate logistic regression analyses the algorithm (i.e., DILI score model) defined the relative contribution of daily dose, logP, and RM and permitted a quantitative assessment of risk of clinical DILI. Furthermore, a clear relationship between calculated DILI scores and DILI risk was obtained when applied to three independent studies. The DILI score model was also functional with drug pairs defined by similar chemical structure and mode of action but divergent toxicities. Specifically, for drug pairs where the RO2 failed, the DILI score correctly identified toxic drugs. Finally, the model was applied to n = 159 clinical cases collected from the National Institutes of Health's LiverTox database to demonstrate that the DILI score correlated with the severity of clinical outcome. Based on daily dose, lipophilicity, and RM, a DILI score algorithm was developed that provides a scale of assessing the severity of DILI risk in humans associated with oral medications. (Hepatology 2016;64:931-940). © 2016 by the American Association for the Study of Liver Diseases. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. JF - Hepatology (Baltimore, Md.) AU - Chen, Minjun AU - Borlak, Jürgen AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR. ; Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 931 EP - 940 VL - 64 IS - 3 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812881614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=A+Model+to+predict+severity+of+drug-induced+liver+injury+in+humans.&rft.au=Chen%2C+Minjun%3BBorlak%2C+J%C3%BCrgen%3BTong%2C+Weida&rft.aulast=Chen&rft.aufirst=Minjun&rft.date=2016-09-01&rft.volume=64&rft.issue=3&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.28678 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/hep.28678 ER - TY - JOUR T1 - Differentiating parts of Cinnamomum cassia using LC-qTOF-MS in conjunction with principal component analysis AN - 1811881422; PQ0003549777 AB - Cinnamon bark (Rou Gui in Chinese), cinnamon twig (Gui Zhi) and shaved cinnamon bark (Gui Sin) have been widely used as spices and in traditional Chinese medicine since ancient times. On-going issues related to quality and authenticity necessitate the development of analytical methods capable of providing an objective evaluation of samples. In this study, chemical fingerprints of cinnamon bark, cinnamon twigs and shaved cinnamon bark were established using liquid chromatography quadruple time-of-flight mass spectrometry in conjunction with principal component analysis (PCA). From 125 samples of cinnamon, we identified the following eight compounds and their the detection ratios: coumarin, cinnamaldehyde, cinnamyl alcohol, cinnamic acid, 2-hydroxycinnamaldehyde, 2-hydroxycinnamic acid, 2-methoxycinnamaldehyde and 4-methoxycinnamaldehyde. Of these, 4-methoxycinnamaldehyde presented the largest variations in detection ratio, making up 64.0, 97.4 and 50.0% in cinnamon bark, cinnamon twig, and shaved cinnamon bark, respectively. The quantities of cinnamyl alcohol, coumarin and cinnamaldehyde also varied between the three parts of the plant. Chemical fingerprints of the three cinnamon samples were established using principal component analysis, the results of which indicate that cinnamon bark and shaved cinnamon bark could be easily differentiated, despite a marked similarity in outward appearance. Cinnamon twig was also shown to depart from the other clusters. The proposed method provides a fast and efficient means of identifying cinnamon herbs for quality control purposes. JF - Biomedical Chromatography AU - Chen, Pei-Yi AU - Yu, Jhe-Wei AU - Lu, Fen-Ling AU - Lin, Mei-Chih AU - Cheng, Hwei-Fang AD - Division of Research and Analysis, Food and Drug Administration, Ministry of Health and Welfare, Taiwan, Republic of China. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1449 EP - 1457 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 9 SN - 0269-3879, 0269-3879 KW - Biotechnology and Bioengineering Abstracts KW - cinnamon KW - cinnamaldehyde KW - Spices KW - Bark KW - Traditional Chinese Medicine KW - Cinnamic acid KW - Mass spectroscopy KW - Liquid chromatography KW - Cinnamomum KW - Quality control KW - Principal components analysis KW - Coumarin KW - alcohols KW - Herbs KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811881422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Chromatography&rft.atitle=Differentiating+parts+of+Cinnamomum+cassia+using+LC-qTOF-MS+in+conjunction+with+principal+component+analysis&rft.au=Chen%2C+Pei-Yi%3BYu%2C+Jhe-Wei%3BLu%2C+Fen-Ling%3BLin%2C+Mei-Chih%3BCheng%2C+Hwei-Fang&rft.aulast=Chen&rft.aufirst=Pei-Yi&rft.date=2016-09-01&rft.volume=30&rft.issue=9&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Biomedical+Chromatography&rft.issn=02693879&rft_id=info:doi/10.1002%2Fbmc.3703 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - cinnamon; cinnamaldehyde; Spices; Bark; Mass spectroscopy; Cinnamic acid; Traditional Chinese Medicine; Liquid chromatography; Principal components analysis; Quality control; Coumarin; alcohols; Herbs; Cinnamomum DO - http://dx.doi.org/10.1002/bmc.3703 ER - TY - JOUR T1 - Teratogenic drugs and their drug interactions with hormonal contraceptives. AN - 1811300188; 27090193 AB - The US Food and Drug Administration (FDA) Guidance for Industry-Drug Interaction Studies, recommends that a potential human teratogen needs to be studied in vivo for effects on contraceptive steroids.(1) This article highlights the need to evaluate the drug-drug interactions (DDIs) between drugs with teratogenic potential and hormonal contraceptives (HCs) during drug development. It also addresses the FDA's effort of communicating DDI findings in product labels to mitigate the risk of unintended pregnancy. © 2016 ASCPT. JF - Clinical pharmacology and therapeutics AU - Ahn, M R AU - Li, L AU - Shon, J AU - Bashaw, E D AU - Kim, M-J AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 217 EP - 219 VL - 100 IS - 3 KW - Abridged Index Medicus KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811300188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Teratogenic+drugs+and+their+drug+interactions+with+hormonal+contraceptives.&rft.au=Ahn%2C+M+R%3BLi%2C+L%3BShon%2C+J%3BBashaw%2C+E+D%3BKim%2C+M-J&rft.aulast=Ahn&rft.aufirst=M&rft.date=2016-09-01&rft.volume=100&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1002%2Fcpt.384 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cpt.384 ER - TY - JOUR T1 - In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotubes. AN - 1811296975; 27106021 AB - Pulmonary exposure to certain forms of carbon nanotubes (CNT) induces fibrosing lesions in the lungs that manifest an acute inflammation followed by chronic interstitial fibrosis. The mechanism of CNT-induced fibrogenesis is largely unknown. The biphasic development with drastically distinct pathologic manifestations suggests a junction of acute-to-chronic transition. Here we analyzed the molecular pathways and regulators underlying the pathologic development of CNT-induced lung fibrosis. Mice were exposed to multi-walled CNT (MWCNT; XNRI MWNT-7, Mitsui; 40 μg) by pharyngeal aspiration for 7 days along with vehicle and carbonaceous controls. Genome-wide microarray analyses of the lungs identified a range of differentially expressed genes that potentially function in the acute-to-chronic transition through pathways involving immune and inflammatory regulation, responses to stress and extracellular stimuli, and cell migration and adhesion. In particular, a T helper 2 (Th2)-driven innate immune response was significantly enriched. We then demonstrated that MWCNT induced the expression of Th2 cytokines interleukin (IL)-4 and IL-13, and a panel of signature downstream genes, such as Il4i1, Chia, and Ccl11/Eotaxin, time dependently. Induction of Th2 cytokines took place in CD4+ T lymphocytes indicating activation of Th2 cells. Furthermore, induction involved activation of a Th2 cell-specific signaling pathway through phosphorylation of STAT6 and up-regulation of GATA-3 to mediate the transcription of Th2 target genes. Our study uncovers activation of a Th2-driven immune/inflammatory response during pulmonary fibrosis development induced by MWCNT. The findings provide novel insights into the molecular events that control the transition from an acute inflammatory response to chronic fibrosis through Th2 functions in CNT-exposed lungs. JF - Archives of toxicology AU - Dong, Jie AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, 1095 Willowdale Road, Morgantown, WV, 26505, USA. ; Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, 1095 Willowdale Road, Morgantown, WV, 26505, USA. qam1@cdc.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 2231 EP - 2248 VL - 90 IS - 9 KW - Index Medicus KW - Pulmonary fibrosis KW - Th2-type response KW - IL-13 KW - Multi-walled carbon nanotubes KW - IL-4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811296975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=In+vivo+activation+of+a+T+helper+2-driven+innate+immune+response+in+lung+fibrosis+induced+by+multi-walled+carbon+nanotubes.&rft.au=Dong%2C+Jie%3BMa%2C+Qiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2016-09-01&rft.volume=90&rft.issue=9&rft.spage=2231&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-016-1711-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-13 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1007/s00204-016-1711-1 ER - TY - JOUR T1 - Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women. AN - 1809599839; 27255803 AB - Urine and serum biomonitoring was used to measure internal exposure to selected dietary estrogens in a cohort of 30 pregnant women. Exposure was measured over a period comprising one-half day in the field (6 h) and one day in a clinic (24 h). Biomonitoring of the dietary phytoestrogens genistein (GEN), daidzein (DDZ) and equol (EQ), as well as the mycoestrogen, zearalenone (ZEN) and its congeners, was conducted using UPLC-MS/MS. Biomonitoring revealed evidence of internal exposure to naturally occurring dietary estrogens during pregnancy. Urinary concentrations of total GEN, DDZ and EQ were similar to levels reported for general adult U.S. Measurable concentrations of total (parent and metabolites) GEN, DDZ and EQ were present in 240, 207 and 2 of 270 serum samples, respectively. Six out of 30 subjects had measurable concentrations of unconjugated GEN and/or DDZ in serum between 0.6 and 7.1 nM. Urine to serum total isoflavone ratios for GEN, DDZ and EQ were 13, 47, and 180, respectively. ZEN and its reductive metabolite, α-zearalenol (α-ZEL), were present in pregnant women (11 out of 30 subjects) as conjugates at levels near the limit of quantification. The average total urinary concentration was 0.10 μg/L for ZEN and 0.11 μg/L for α-ZEL. Copyright © 2016. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Fleck, Stefanie C AU - Churchwell, Mona I AU - Doerge, Daniel R AU - Teeguarden, Justin G AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: stefanie.fleck@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: mona.churchwell@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: daniel.doerge@fda.hhs.gov. ; Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99352, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 93771, USA. Electronic address: jt@pnnl.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 19 EP - 27 VL - 95 KW - Index Medicus KW - Zearalenone KW - Soy isoflavones KW - Exposure KW - Endocrine disruptors KW - Biomonitoring KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809599839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Urine+and+serum+biomonitoring+of+exposure+to+environmental+estrogens+II%3A+Soy+isoflavones+and+zearalenone+in+pregnant+women.&rft.au=Fleck%2C+Stefanie+C%3BChurchwell%2C+Mona+I%3BDoerge%2C+Daniel+R%3BTeeguarden%2C+Justin+G&rft.aulast=Fleck&rft.aufirst=Stefanie&rft.date=2016-09-01&rft.volume=95&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.05.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.05.021 ER - TY - JOUR T1 - Association of MHC region SNPs with irritant susceptibility in healthcare workers. AN - 1809046673; 27258892 AB - Irritant contact dermatitis is the most common work-related skin disease, especially affecting workers in "wet-work" occupations. This study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) within the major histocompatibility complex (MHC) and skin irritant response in a group of healthcare workers. 585 volunteer healthcare workers were genotyped for MHC SNPs and patch tested with three different irritants: sodium lauryl sulfate (SLS), sodium hydroxide (NaOH) and benzalkonium chloride (BKC). Genotyping was performed using Illumina Goldengate MHC panels. A number of SNPs within the MHC Class I (OR2B3, TRIM31, TRIM10, TRIM40 and IER3), Class II (HLA-DPA1, HLA-DPB1) and Class III (C2) genes were associated (p < 0.001) with skin response to tested irritants in different genetic models. Linkage disequilibrium patterns and functional annotations identified two SNPs in the TRIM40 (rs1573298) and HLA-DPB1 (rs9277554) genes, with a potential impact on gene regulation. In addition, SNPs in PSMB9 (rs10046277 and ITPR3 (rs499384) were associated with hand dermatitis. The results are of interest as they demonstrate that genetic variations in inflammation-related genes within the MHC can influence chemical-induced skin irritation and may explain the connection between inflamed skin and propensity to subsequent allergic contact sensitization. JF - Journal of immunotoxicology AU - Yucesoy, Berran AU - Talzhanov, Yerkebulan AU - Michael Barmada, M AU - Johnson, Victor J AU - Kashon, Michael L AU - Baron, Elma AU - Wilson, Nevin W AU - Frye, Bonnie AU - Wang, Wei AU - Fluharty, Kara AU - Gharib, Rola AU - Meade, Jean AU - Germolec, Dori AU - Luster, Michael I AU - Nedorost, Susan AD - a Health Effects Laboratory Division , CDC/NIOSH , Morgantown , WV , USA ; ; b Department of Human Genetics, Graduate School of Public Health , University of Pittsburgh , Pittsburgh , PA , USA ; ; c BRT-Burleson Research Technologies , Morrisville , NC , USA ; ; d University Hospitals Case Medical Center, Case Western Reserve University , Cleveland , OH , USA ; ; e Department of Pediatrics, School of Medicine , University of Nevada , Reno , NV , USA ; ; f Department of Dermatology, School of Medicine , West Virginia University , Morgantown , WV , USA ; ; g Office of Director, CDC/NIOSH , Morgantown , WV , USA ; ; h Toxicology Branch, DNTP/NIEHS, Research Triangle Park , NC , USA ; ; i School of Public Health, West Virginia University , Morgantown , WV , USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 738 EP - 744 VL - 13 IS - 5 KW - Index Medicus KW - Genetics KW - healthcare workers KW - irritant contact dermatitis KW - MHC UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809046673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Association+of+MHC+region+SNPs+with+irritant+susceptibility+in+healthcare+workers.&rft.au=Yucesoy%2C+Berran%3BTalzhanov%2C+Yerkebulan%3BMichael+Barmada%2C+M%3BJohnson%2C+Victor+J%3BKashon%2C+Michael+L%3BBaron%2C+Elma%3BWilson%2C+Nevin+W%3BFrye%2C+Bonnie%3BWang%2C+Wei%3BFluharty%2C+Kara%3BGharib%2C+Rola%3BMeade%2C+Jean%3BGermolec%2C+Dori%3BLuster%2C+Michael+I%3BNedorost%2C+Susan&rft.aulast=Yucesoy&rft.aufirst=Berran&rft.date=2016-09-01&rft.volume=13&rft.issue=5&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.3109%2F1547691X.2016.1173135 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-03 N1 - Date revised - 2017-02-06 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.3109/1547691X.2016.1173135 ER - TY - JOUR T1 - Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions. AN - 1804867467; 27309676 AB - In October 2013, the International Life Sciences Institute - Health and Environmental Sciences Institute Immunotoxicology Technical Committee (ILSI-HESI ITC) held a one-day workshop entitled, "Workshop on Cytokine Release: State-of-the-Science, Current Challenges and Future Directions". The workshop brought together scientists from pharmaceutical, academic, health authority, and contract research organizations to discuss novel approaches and current challenges for the use of in vitro cytokine release assays (CRAs) for the identification of cytokine release syndrome (CRS) potential of novel monoclonal antibody (mAb) therapeutics. Topics presented encompassed a regulatory perspective on cytokine release and assessment, case studies regarding the translatability of preclinical cytokine data to the clinic, and the latest state of the science of CRAs, including comparisons between mAb therapeutics within one platform and across several assay platforms, a novel physiological assay platform, and assay optimization approaches such as determination of FcR expression profiles and use of statistical tests. The data and approaches presented confirmed that multiple CRA platforms are in use for identification of CRS potential and that the choice of a particular CRA platform is highly dependent on the availability of resources for individual laboratories (e.g. positive and negative controls, number of human blood donors), the assay through-put required, and the mechanism-of-action of the therapeutic candidate to be tested. Workshop participants agreed that more data on the predictive performance of CRA platforms is needed, and current efforts to compare in vitro assay results with clinical cytokine assessments were discussed. In summary, many laboratories continue to focus research efforts on the improvement of the translatability of current CRA platforms as well explore novel approaches which may lead to more accurate, and potentially patient-specific, CRS prediction in the future. Copyright © 2016. Published by Elsevier Ltd. JF - Cytokine AU - Grimaldi, Christine AU - Finco, Deborah AU - Fort, Madeline M AU - Gliddon, Daniel AU - Harper, Kirsty AU - Helms, Whitney S AU - Mitchell, Jane A AU - O'Lone, Raegan AU - Parish, Stanley T AU - Piche, Marie-Soleil AU - Reed, Daniel M AU - Reichmann, Gabriele AU - Ryan, Patricia C AU - Stebbings, Richard AU - Walker, Mindi AD - Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA. ; Pfizer Inc., 1 Eastern Point Road, Groton, CT 06340, USA. ; Amgen, Inc., Comparative Biology and Safety Sciences, USA. ; Envigo, Woolley Road, Alconbury, Huntingdon, Cambridgeshire PE28 4HS, United Kingdom. ; US Food and Drug Administration, 10903 New Hampshire Ave, Rockville, MD, USA. ; Imperial College London, London SW3 6LY, United Kingdom. ; ILSI Health and Environmental Sciences Institute, 1156 15th St NW, Suite 200, Washington, DC 20005, USA. ; ILSI Health and Environmental Sciences Institute, 1156 15th St NW, Suite 200, Washington, DC 20005, USA. Electronic address: sparish@hesiglobal.org. ; Charles River Laboratories, 20222 Transcanadien, Senneville, QC H9X 3R3, Canada. ; Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich Str. 51-59, 63225 Langen, Germany. ; Medimmune, Inc., One MedImmune Way, Gaithersburg, MD 20878, USA. ; The National Institute of Biological Standards and Controls, Blanche Ln, South Mimms, Potters Bar EN6 3QG, United Kingdom. ; Johnson and Johnson, Inc., 1 Johnson and Johnson Plaza, New Brunswick, NJ 08933, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 101 EP - 108 VL - 85 KW - Index Medicus KW - Cytokine release syndrome KW - Pro-inflammatory cytokines KW - Cytokine release assay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1804867467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Cytokine+release%3A+A+workshop+proceedings+on+the+state-of-the-science%2C+current+challenges+and+future+directions.&rft.au=Grimaldi%2C+Christine%3BFinco%2C+Deborah%3BFort%2C+Madeline+M%3BGliddon%2C+Daniel%3BHarper%2C+Kirsty%3BHelms%2C+Whitney+S%3BMitchell%2C+Jane+A%3BO%27Lone%2C+Raegan%3BParish%2C+Stanley+T%3BPiche%2C+Marie-Soleil%3BReed%2C+Daniel+M%3BReichmann%2C+Gabriele%3BRyan%2C+Patricia+C%3BStebbings%2C+Richard%3BWalker%2C+Mindi&rft.aulast=Grimaldi&rft.aufirst=Christine&rft.date=2016-09-01&rft.volume=85&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=1096-0023&rft_id=info:doi/10.1016%2Fj.cyto.2016.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cyto.2016.06.006 ER - TY - JOUR T1 - Integrated decision strategies for skin sensitization hazard. AN - 1804855247; 26851134 AB - One of the top priorities of the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVAM) is the identification and evaluation of non-animal alternatives for skin sensitization testing. Although skin sensitization is a complex process, the key biological events of the process have been well characterized in an adverse outcome pathway (AOP) proposed by the Organisation for Economic Co-operation and Development (OECD). Accordingly, ICCVAM is working to develop integrated decision strategies based on the AOP using in vitro, in chemico and in silico information. Data were compiled for 120 substances tested in the murine local lymph node assay (LLNA), direct peptide reactivity assay (DPRA), human cell line activation test (h-CLAT) and KeratinoSens assay. Data for six physicochemical properties, which may affect skin penetration, were also collected, and skin sensitization read-across predictions were performed using OECD QSAR Toolbox. All data were combined into a variety of potential integrated decision strategies to predict LLNA outcomes using a training set of 94 substances and an external test set of 26 substances. Fifty-four models were built using multiple combinations of machine learning approaches and predictor variables. The seven models with the highest accuracy (89-96% for the test set and 96-99% for the training set) for predicting LLNA outcomes used a support vector machine (SVM) approach with different combinations of predictor variables. The performance statistics of the SVM models were higher than any of the non-animal tests alone and higher than simple test battery approaches using these methods. These data suggest that computational approaches are promising tools to effectively integrate data sources to identify potential skin sensitizers without animal testing. Published 2016. This article has been contributed to by US Government employees and their work is in the public domain in the USA. Published 2016. This article has been contributed to by US Government employees and their work is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Strickland, Judy AU - Zang, Qingda AU - Kleinstreuer, Nicole AU - Paris, Michael AU - Lehmann, David M AU - Choksi, Neepa AU - Matheson, Joanna AU - Jacobs, Abigail AU - Lowit, Anna AU - Allen, David AU - Casey, Warren AD - ILS, Research Triangle Park, North Carolina, 27709, USA. ; EPA/NHEERL/EPHD/CIB, Research Triangle Park, North Carolina, 27709, USA. ; U.S. Consumer Product Safety Commission, Bethesda, Maryland, 20814, USA. ; FDA/CDER, Silver Spring, Maryland, 20993, USA. ; EPA/OCSPP/OPP/HED, Washington, District of Columbia, 20460, USA. ; NIH/NIEHS/DNTP/NICEATM, Research Triangle Park, North Carolina, 27709, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1150 EP - 1162 VL - 36 IS - 9 KW - Index Medicus KW - support vector machine KW - skin sensitization KW - machine learning KW - LLNA KW - DPRA KW - h-CLAT KW - KeratinoSens KW - integrated decision strategy KW - allergic contact dermatitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1804855247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Integrated+decision+strategies+for+skin+sensitization+hazard.&rft.au=Strickland%2C+Judy%3BZang%2C+Qingda%3BKleinstreuer%2C+Nicole%3BParis%2C+Michael%3BLehmann%2C+David+M%3BChoksi%2C+Neepa%3BMatheson%2C+Joanna%3BJacobs%2C+Abigail%3BLowit%2C+Anna%3BAllen%2C+David%3BCasey%2C+Warren&rft.aulast=Strickland&rft.aufirst=Judy&rft.date=2016-09-01&rft.volume=36&rft.issue=9&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3281 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-14 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1002/jat.3281 ER - TY - JOUR T1 - Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb. AN - 1802736760; 27139982 AB - Four new dianthrone glycosides, named polygonumnolides C1-C4 (1-4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5-6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1-4 showed weak hepatotoxicity against L-02 cell lines with IC50 values of 313.05, 205.20, 294.20, and 207.35 μM, respectively. JF - Journal of Asian natural products research AU - Yang, Jian-Bo AU - Li, Li AU - Dai, Zhong AU - Wu, Yu AU - Geng, Xing-Chao AU - Li, Bo AU - Ma, Shuang-Cheng AU - Wang, Ai-Guo AU - Su, Ya-Lun AD - a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China. ; b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 813 EP - 822 VL - 18 IS - 9 KW - Anthracenes KW - 0 KW - Drugs, Chinese Herbal KW - Glycosides KW - Emodin KW - KA46RNI6HN KW - Index Medicus KW - polygonumnolides C1–C4 KW - dianthrone glycosides KW - Polygonum multiflorum KW - L-02 cell lines KW - Molecular Structure KW - Emodin -- chemistry KW - Stereoisomerism KW - Nuclear Magnetic Resonance, Biomolecular KW - Humans KW - Plant Roots -- chemistry KW - Drugs, Chinese Herbal -- chemistry KW - Anthracenes -- isolation & purification KW - Glycosides -- isolation & purification KW - Anthracenes -- chemistry KW - Glycosides -- chemistry KW - Liver -- drug effects KW - Drugs, Chinese Herbal -- isolation & purification KW - Polygonum -- chemistry KW - Drugs, Chinese Herbal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802736760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Asian+natural+products+research&rft.atitle=Polygonumnolides+C1-C4%3B+minor+dianthrone+glycosides+from+the+roots+of+Polygonum+multiflorum+Thunb.&rft.au=Yang%2C+Jian-Bo%3BLi%2C+Li%3BDai%2C+Zhong%3BWu%2C+Yu%3BGeng%2C+Xing-Chao%3BLi%2C+Bo%3BMa%2C+Shuang-Cheng%3BWang%2C+Ai-Guo%3BSu%2C+Ya-Lun&rft.aulast=Yang&rft.aufirst=Jian-Bo&rft.date=2016-09-01&rft.volume=18&rft.issue=9&rft.spage=813&rft.isbn=&rft.btitle=&rft.title=Journal+of+Asian+natural+products+research&rft.issn=1477-2213&rft_id=info:doi/10.1080%2F10286020.2016.1171758 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-03 N1 - Date created - 2016-07-07 N1 - Date revised - 2017-02-07 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1080/10286020.2016.1171758 ER - TY - JOUR T1 - Assessing the protection of the nanomaterial workforce. AN - 1793569167; 26865347 AB - Responsible development of any technology, including nanotechnology, requires protecting workers, the first people to be exposed to the products of the technology. In the case of nanotechnology, this is difficult to achieve because in spite of early evidence raising health and safety concerns, there are uncertainties about hazards and risks. The global response to these concerns has been the issuance by authoritative agencies of precautionary guidance to strictly control exposures to engineered nanomaterials (ENMs). This commentary summarizes discussions at the "Symposium on the Health Protection of Nanomaterial Workers" held in Rome (25 and 26 February 2015). There scientists and practitioners from 11 countries took stock of what is known about hazards and risks resulting from exposure to ENMs, confirmed that uncertainties still exist, and deliberated on what it would take to conduct a global assessment of how well workers are being protected from potentially harmful exposures. JF - Nanotoxicology AU - Schulte, Paul A AU - Iavicoli, Ivo AU - Rantanen, Jorma H AU - Dahmann, Dirk AU - Iavicoli, Sergio AU - Pipke, Rüdiger AU - Guseva Canu, Irina AU - Boccuni, Fabio AU - Ricci, Maximo AU - Polci, Maria Letizia AU - Sabbioni, Enrico AU - Pietroiusti, Antonio AU - Mantovani, Elvio AD - a Education and Information Division , Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH) , Cincinnati , OH , USA . ; b Department of Public Health , University of Naples Federico II , Naples , Italy . ; c International Commission on Occupational Health (ICOH) , Hyvinkää , Finland . ; d Institute for the Research on Hazardous Substances (IGF) , Bochum , Germany . ; e Department of Occupational and Environmental Medicine , Epidemiology and Hygiene, Italian Workers' Compensation Authority (INAIL) , Rome , Italy . ; f Federal Institute for Occupational Safety and Health (BAuA) , Dortmund , Germany . ; g Department of Occupational Health , French Institute for Public Health Surveillance, Occupational Health Department , St. Maurice , France . ; h SHO-NANO , Campana , Argentina . ; i Italian Ministry of Health , Rome , Italy . ; j Italian Society of Nanotoxicology , Rome , Italy . ; k Department of Biomedicine and Prevention , University of Rome Tor Vergata , Rome , Italy , and. ; l Italian Association for Industrial Research (AIRI) , Rome , Italy. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1013 EP - 1019 VL - 10 IS - 7 KW - Index Medicus KW - occupational exposure limits KW - precautionary guidance KW - toxicity KW - Control procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793569167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Assessing+the+protection+of+the+nanomaterial+workforce.&rft.au=Schulte%2C+Paul+A%3BIavicoli%2C+Ivo%3BRantanen%2C+Jorma+H%3BDahmann%2C+Dirk%3BIavicoli%2C+Sergio%3BPipke%2C+R%C3%BCdiger%3BGuseva+Canu%2C+Irina%3BBoccuni%2C+Fabio%3BRicci%2C+Maximo%3BPolci%2C+Maria+Letizia%3BSabbioni%2C+Enrico%3BPietroiusti%2C+Antonio%3BMantovani%2C+Elvio&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2016-09-01&rft.volume=10&rft.issue=7&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2015.1132347 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/17435390.2015.1132347 ER - TY - JOUR T1 - Evaluation of the effect of valence state on cerium oxide nanoparticle toxicity following intratracheal instillation in rats. AN - 1793567125; 26898289 AB - Cerium (Ce) is becoming a popular metal for use in electrochemical applications. When in the form of cerium oxide (CeO2), Ce can exist in both 3 + and 4 + valence states, acting as an ideal catalyst. Previous in vitro and in vivo evidence have demonstrated that CeO2 has either anti- or pro-oxidant properties, possibly due to the ability of the nanoparticles to transition between valence states. Therefore, we chose to chemically modify the nanoparticles to shift the valence state toward 3+. During the hydrothermal synthesis process, 10 mol% gadolinium (Gd) and 20 mol% Gd, were substituted into the lattice of the CeO2 nanoparticles forming a perfect solid solution with various A-site valence states. These two Gd-doped CeO2 nanoparticles were compared to pure CeO2 nanoparticles. Preliminary characteristics indicated that doping results in minimal size and zeta potential changes but alters valence state. Following characterization, male Sprague-Dawley rats were exposed to 0.5 or 1.0 mg/kg nanoparticles via a single intratracheal instillation. Animals were sacrificed and bronchoalveolar lavage fluid and various tissues were collected to determine the effect of valence state and oxygen vacancies on toxicity 1-, 7-, or 84-day post-exposure. Results indicate that damage, as measured by elevations in lactate dehydrogenase, occurred within 1-day post-exposure and was sustained 7-day post-exposure, but subsided to control levels 84-day post-exposure. Furthermore, no inflammatory signaling or lipid peroxidation occurred following exposure with any of the nanoparticles. Our results implicate that valence state has a minimal effect on CeO2 nanoparticle toxicity in vivo. JF - Nanotoxicology AU - Dunnick, Katherine M AU - Morris, Anna M AU - Badding, Melissa A AU - Barger, Mark AU - Stefaniak, Aleksandr B AU - Sabolsky, Edward M AU - Leonard, Stephen S AD - a HELD , National Institute for Occupational Safety and Health , Morgantown , WV , USA . ; c RHD , National Institute for Occupational Safety and Health , Morgantown , WV , USA , and. ; d WVU Benjamin M. Statler College of Engineering and Mineral Resources , Morgantown , WV , USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 992 EP - 1000 VL - 10 IS - 7 KW - Index Medicus KW - intratracheal instillation KW - Cerium oxide KW - nanotoxicity KW - valence state KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793567125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Evaluation+of+the+effect+of+valence+state+on+cerium+oxide+nanoparticle+toxicity+following+intratracheal+instillation+in+rats.&rft.au=Dunnick%2C+Katherine+M%3BMorris%2C+Anna+M%3BBadding%2C+Melissa+A%3BBarger%2C+Mark%3BStefaniak%2C+Aleksandr+B%3BSabolsky%2C+Edward+M%3BLeonard%2C+Stephen+S&rft.aulast=Dunnick&rft.aufirst=Katherine&rft.date=2016-09-01&rft.volume=10&rft.issue=7&rft.spage=992&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2016.1157220 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Mol Sci. 2014;15(4):6072-85 [24727375] Biol Trace Elem Res. 2015 Jul;166(1):96-107 [25778836] Biomed Pharmacother. 2015 Jul;73:80-6 [26211586] J Exp Med. 2003 May 5;197(9):1107-17 [12719479] Chest. 1983 May;83(5):780-3 [6839821] Occup Environ Med. 1994 Mar;51(3):195-9 [8130849] Am J Ind Med. 1995 Mar;27(3):349-58 [7747741] Regul Toxicol Pharmacol. 1995 Feb;21(1):123-35 [7784625] Fundam Appl Toxicol. 1995 Nov;28(1):65-70 [8566485] Int J Toxicol. 2006 Nov-Dec;25(6):451-7 [17132603] Biomaterials. 2007 Apr;28(10):1918-25 [17222903] Toxicology. 2008 Mar 12;245(1-2):90-100 [18243471] ACS Nano. 2008 Oct 28;2(10):2121-34 [19206459] Toxicol Lett. 2009 Jun 1;187(2):77-83 [19429248] Nanotechnology. 2010 Jul 16;21(28):285103 [20562477] Nanomedicine. 2010 Oct;6(5):698-705 [20172051] Crit Rev Toxicol. 2011 Mar;41(3):213-29 [21244219] ScientificWorldJournal. 2011;11:801-25 [21479351] ACS Nano. 2011 Jun 28;5(6):4537-49 [21612305] Toxicol Lett. 2011 Aug 28;205(2):105-15 [21624445] Nanotoxicology. 2011 Sep;5(3):312-25 [20925443] Int J Nanomedicine. 2011;6:2327-35 [22072870] Toxicol Appl Pharmacol. 2012 Aug 1;262(3):255-64 [22613087] PLoS One. 2012;7(8):e42656 [22880072] Nanotoxicology. 2013 Dec;7(8):1338-50 [23061914] Nanotoxicology. 2014 Nov;8(7):786-98 [23914771] Toxicol Appl Pharmacol. 2015 Oct 1;288(1):63-73 [26210349] Arch Toxicol. 2016 Feb;90(2):269-78 [25618551] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/17435390.2016.1157220 ER - TY - JOUR T1 - Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells. AN - 1811294643; 27320055 AB - Designer drugs such as synthetic psychostimulants are indicative of a worldwide problem of drug abuse and addiction. In addition to methamphetamine (METH), these drugs include 3,4-methylenedioxy-methamphetamine (MDMA) and commercial preparations of synthetic cathinones including 3,4-methylenedioxypyrovalerone (MDPV), typically referred to as "bath salts." These psychostimulants exert neurotoxic effects by altering monoamine systems in the brain. Additionally, METH and MDMA adversely affect the integrity of the blood-brain barrier (BBB): there are no current reports on the effects of MDPV on the BBB. The aim of this study was to compare the effects of METH, MDMA and MDPV on bovine brain microvessel endothelial cells (bBMVECs), an accepted in vitro model of the BBB. Confluent bBMVEC monolayers were treated with METH, MDMA and MDPV (0.5mM-2.5mM) for 24h. METH and MDMA increased lactate dehydrogenase release only at the highest concentration (2.5mM), whereas MDPV induced cytotoxicity at all concentrations. MDMA and METH decreased cellular proliferation only at 2.5mM, with similar effects observed after MDPV exposures starting at 1mM. Only MDPV increased reactive oxygen species production at all concentrations tested whereas all 3 drugs increased nitric oxide production. Morphological analysis revealed different patterns of compound-induced cell damage. METH induced vacuole formation at 1mM and disruption of the monolayer at 2.5mM. MDMA induced disruption of the endothelial monolayer from 1mM without vacuolization. On the other hand, MDPV induced monolayer disruption at doses ≥0.5mM without vacuole formation; at 2.5mM, the few remaining cells lacked endothelial morphology. These data suggest that even though these synthetic psychostimulants alter monoaminergic systems, they each induce BBB toxicity by different mechanisms with MDPV being the most toxic. Published by Elsevier Ireland Ltd. JF - Neuroscience letters AU - Rosas-Hernandez, Hector AU - Cuevas, Elvis AU - Lantz, Susan M AU - Rice, Kenner C AU - Gannon, Brenda M AU - Fantegrossi, William E AU - Gonzalez, Carmen AU - Paule, Merle G AU - Ali, Syed F AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. ; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, NIDA/NIAAA, Bethesda, MD, USA. ; Department of Pharmacology & Toxicology, UAMS, Little Rock, AR, USA. ; Facultad de Ciencias Quimicas, UASLP, SLP, Mexico. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. Electronic address: Syed.Ali@fda.hhs.gov. Y1 - 2016/08/26/ PY - 2016 DA - 2016 Aug 26 SP - 125 EP - 130 VL - 629 KW - Index Medicus KW - MDPV KW - Methamphetamine KW - Cytotoxicity KW - Blood-brain barrier KW - MDMA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811294643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Methamphetamine%2C+3%2C4-methylenedioxymethamphetamine+%28MDMA%29+and+3%2C4-methylenedioxypyrovalerone+%28MDPV%29+induce+differential+cytotoxic+effects+in+bovine+brain+microvessel+endothelial+cells.&rft.au=Rosas-Hernandez%2C+Hector%3BCuevas%2C+Elvis%3BLantz%2C+Susan+M%3BRice%2C+Kenner+C%3BGannon%2C+Brenda+M%3BFantegrossi%2C+William+E%3BGonzalez%2C+Carmen%3BPaule%2C+Merle+G%3BAli%2C+Syed+F&rft.aulast=Rosas-Hernandez&rft.aufirst=Hector&rft.date=2016-08-26&rft.volume=629&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=1872-7972&rft_id=info:doi/10.1016%2Fj.neulet.2016.06.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neulet.2016.06.029 ER - TY - JOUR T1 - sNebula, a network-based algorithm to predict binding between human leukocyte antigens and peptides. AN - 1814677310; 27558848 AB - Understanding the binding between human leukocyte antigens (HLAs) and peptides is important to understand the functioning of the immune system. Since it is time-consuming and costly to measure the binding between large numbers of HLAs and peptides, computational methods including machine learning models and network approaches have been developed to predict HLA-peptide binding. However, there are several limitations for the existing methods. We developed a network-based algorithm called sNebula to address these limitations. We curated qualitative Class I HLA-peptide binding data and demonstrated the prediction performance of sNebula on this dataset using leave-one-out cross-validation and five-fold cross-validations. This algorithm can predict not only peptides of different lengths and different types of HLAs, but also the peptides or HLAs that have no existing binding data. We believe sNebula is an effective method to predict HLA-peptide binding and thus improve our understanding of the immune system. JF - Scientific reports AU - Luo, Heng AU - Ye, Hao AU - Ng, Hui Wen AU - Sakkiah, Sugunadevi AU - Mendrick, Donna L AU - Hong, Huixiao AD - National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 USA. Y1 - 2016/08/25/ PY - 2016 DA - 2016 Aug 25 SP - 32115 VL - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814677310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=sNebula%2C+a+network-based+algorithm+to+predict+binding+between+human+leukocyte+antigens+and+peptides.&rft.au=Luo%2C+Heng%3BYe%2C+Hao%3BNg%2C+Hui+Wen%3BSakkiah%2C+Sugunadevi%3BMendrick%2C+Donna+L%3BHong%2C+Huixiao&rft.aulast=Luo&rft.aufirst=Heng&rft.date=2016-08-25&rft.volume=6&rft.issue=&rft.spage=32115&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep32115 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep32115 ER - TY - JOUR T1 - The immature rat as a potential model for chemical risks to children: Ontogeny of selected hepatic P450s. AN - 1810354085; 27387539 AB - Concern about potential susceptibilities of infants and children to chemicals has led to the consideration of immature rodents as potential test surrogates. Maturation of some hepatic microsomal cytochrome P450s (CYPs), that participate in metabolic activation of organic solvents and polycyclic aromatic hydrocarbons (PAHs), may differ significantly between humans and rodents. The present investigation was undertaken to delineate the ontogeny of selected hepatic CYPs in male and female Sprague-Dawley (S-D) rats, and to contrast them with developmental profiles in humans. Microsomes were prepared from the liver of sexed and unsexed postnatal day (PND) 1-90 rats, and total CYP450 levels, as well as CYP1A1/2, CYP2E1 and CYP2B1/2 activities and protein, were quantified. CYP1A1/2 and CYP2E1 activity and expression rose rapidly after birth, peaked from PND 21-40/50, and declined substantially to adult values by PND 90. The same ontogenic profiles were manifested when the enzyme activities were expressed per entire liver or liver normalized to body weight. CYP1A1/2 and CYP2E1 activity and protein expression were well correlated. CYP2B1/2 activity peaked abruptly on PND 21 and declined irregularly to adult values. These patterns are in contrast to human CYP1A2 and CYP2E1, which are reported to progressively increase in liver during the first few months to years of life. The three CYP protein developmental profiles were largely gender independent in rats. The immature rat does not appear to be a suitable model for assessing risks posed to infants and children by chemicals metabolically activated by CYP2E1, based on the findings of greater carbon tetrachloride hepatotoxicity in preweanlings and weanlings than in adult animals. Additional studies are required to determine whether immature S-D rats may be used as an animal model for substrates of other CYPs, as total CYP450 levels in the liver progressively rose during maturation, similarly to humans. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. JF - Chemico-biological interactions AU - McPhail, Brooks T AU - White, Catherine A AU - Cummings, Brian S AU - Muralidhara, Srinivasa AU - Wilson, Jewell T AU - Bruckner, James V AD - Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy and Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. ; ATSDR, Division of Toxicology and Human Health Sciences, Department of Health and Human Services, Atlanta, GA 30333, USA. ; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy and Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. Electronic address: bruckner@uga.edu. Y1 - 2016/08/25/ PY - 2016 DA - 2016 Aug 25 SP - 167 EP - 177 VL - 256 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Steroid Hydroxylases KW - EC 1.14.- KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1A2 KW - Cytochrome P-450 CYP2B1 KW - steroid 16-beta-hydroxylase KW - Index Medicus KW - Carbon tetrachloride KW - Metabolic activation KW - Cytochrome P450 ontogeny KW - Hepatotoxicity KW - Children’s risk assessment KW - Animal model KW - Animals KW - Age Factors KW - Microsomes, Liver -- metabolism KW - Humans KW - Cytochrome P-450 CYP1A2 -- metabolism KW - Cytochrome P-450 CYP2B1 -- metabolism KW - Steroid Hydroxylases -- metabolism KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Child KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Risk Assessment KW - Activation, Metabolic -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Microsomes, Liver -- drug effects KW - Female KW - Male KW - Liver -- pathology KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Liver -- growth & development KW - Liver -- drug effects KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Carbon Tetrachloride -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1810354085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=The+immature+rat+as+a+potential+model+for+chemical+risks+to+children%3A+Ontogeny+of+selected+hepatic+P450s.&rft.au=McPhail%2C+Brooks+T%3BWhite%2C+Catherine+A%3BCummings%2C+Brian+S%3BMuralidhara%2C+Srinivasa%3BWilson%2C+Jewell+T%3BBruckner%2C+James+V&rft.aulast=McPhail&rft.aufirst=Brooks&rft.date=2016-08-25&rft.volume=256&rft.issue=&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2016.07.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-30 N1 - Date created - 2016-08-08 N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-01 DO - http://dx.doi.org/10.1016/j.cbi.2016.07.005 ER - TY - JOUR T1 - Estimating Inorganic Arsenic Exposure from U.S. Rice and Total Water Intakes. AN - 1859718423; 27539714 AB - Among nonoccupationally exposed U.S. residents, drinking water and diet are considered primary exposure pathways for inorganic arsenic (iAs). In drinking water, iAs is the primary form of arsenic (As), while dietary As speciation techniques are used to differentiate iAs from less toxic arsenicals in food matrices. To estimate the distribution of iAs exposure rates from drinking water intakes and rice consumption in the U.S. population and ethnic- and age-based subpopulations. The distribution of iAs in drinking water was estimated by population, weighting the iAs concentrations for each drinking water utility in the Second Six-Year Review data set. To estimate the distribution of iAs concentrations in rice ingested by U.S. consumers, 54 grain-specific, production-weighted composites of rice obtained from U.S. mills were extracted and speciated using both a quantitative dilute nitric acid extraction and speciation (DNAS) and an in vitro gastrointestinal assay to provide an upper bound and bioaccessible estimates, respectively. Daily drinking water intake and rice consumption rate distributions were developed using data from the What We Eat in America (WWEIA) study. Using these datasets, the Stochastic Human Exposure and Dose Simulation (SHEDS) model estimated mean iAs exposures from drinking water and rice were 4.2 μg/day and 1.4 μg/day, respectively, for the entire U.S. population. The Tribal, Asian, and Pacific population exhibited the highest mean daily exposure of iAs from cooked rice (2.8 μg/day); the mean exposure rate for children between ages 1 and 2 years in this population is 0.104 μg/kg body weight (BW)-day. An average consumer drinking 1.5 L of water daily that contains between 2 and 3 ng iAs/mL is exposed to approximately the same amount of iAs as a mean Tribal, Asian, and Pacific consumer is exposed to from rice. JF - Environmental health perspectives AU - Mantha, Madhavi AU - Yeary, Edward AU - Trent, John AU - Creed, Patricia A AU - Kubachka, Kevin AU - Hanley, Traci AU - Shockey, Nohora AU - Heitkemper, Douglas AU - Caruso, Joseph AU - Xue, Jianping AU - Rice, Glenn AU - Wymer, Larry AU - Creed, John T AD - Oak Ridge Institute for Science and Education Scholar, U.S. Environmental Protection Agency (U.S. EPA), National Exposure Research Laboratory (NERL), Cincinnati, Ohio, USA. ; Student Service Contractor, U.S. EPA, NERL, Cincinnati, Ohio, USA. ; U.S. EPA, NERL, Cincinnati, Ohio, USA. ; U.S. Food and Drug Administration (U.S. FDA), Forensic Chemistry Center, Cincinnati, Ohio, USA. ; University of Cincinnati, Department of Chemistry, Cincinnati, Ohio, USA. ; U.S. EPA, NERL, Research Triangle Park, North Carolina, USA. ; U.S. EPA, National Center for Environmental Assessment (NCEA), Cincinnati, Ohio, USA. Y1 - 2016/08/19/ PY - 2016 DA - 2016 Aug 19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859718423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Estimating+Inorganic+Arsenic+Exposure+from+U.S.+Rice+and+Total+Water+Intakes.&rft.au=Mantha%2C+Madhavi%3BYeary%2C+Edward%3BTrent%2C+John%3BCreed%2C+Patricia+A%3BKubachka%2C+Kevin%3BHanley%2C+Traci%3BShockey%2C+Nohora%3BHeitkemper%2C+Douglas%3BCaruso%2C+Joseph%3BXue%2C+Jianping%3BRice%2C+Glenn%3BWymer%2C+Larry%3BCreed%2C+John+T&rft.aulast=Mantha&rft.aufirst=Madhavi&rft.date=2016-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology. AN - 1811843913; 27367298 AB - The U.S. Environmental Protection Agency's (EPA) ToxCast program is testing a large library of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to support the development of improved toxicity prediction models. Launched in 2007, Phase I of the program screened 310 chemicals, mostly pesticides, across hundreds of ToxCast assay end points. In Phase II, the ToxCast library was expanded to 1878 chemicals, culminating in the public release of screening data at the end of 2013. Subsequent expansion in Phase III has resulted in more than 3800 chemicals actively undergoing ToxCast screening, 96% of which are also being screened in the multi-Agency Tox21 project. The chemical library unpinning these efforts plays a central role in defining the scope and potential application of ToxCast HTS results. The history of the phased construction of EPA's ToxCast library is reviewed, followed by a survey of the library contents from several different vantage points. CAS Registry Numbers are used to assess ToxCast library coverage of important toxicity, regulatory, and exposure inventories. Structure-based representations of ToxCast chemicals are then used to compute physicochemical properties, substructural features, and structural alerts for toxicity and biotransformation. Cheminformatics approaches using these varied representations are applied to defining the boundaries of HTS testability, evaluating chemical diversity, and comparing the ToxCast library to potential target application inventories, such as used in EPA's Endocrine Disruption Screening Program (EDSP). Through several examples, the ToxCast chemical library is demonstrated to provide comprehensive coverage of the knowledge domains and target inventories of potential interest to EPA. Furthermore, the varied representations and approaches presented here define local chemistry domains potentially worthy of further investigation (e.g., not currently covered in the testing library or defined by toxicity "alerts") to strategically support data mining and predictive toxicology modeling moving forward. JF - Chemical research in toxicology AU - Richard, Ann M AU - Judson, Richard S AU - Houck, Keith A AU - Grulke, Christopher M AU - Volarath, Patra AU - Thillainadarajah, Inthirany AU - Yang, Chihae AU - Rathman, James AU - Martin, Matthew T AU - Wambaugh, John F AU - Knudsen, Thomas B AU - Kancherla, Jayaram AU - Mansouri, Kamel AU - Patlewicz, Grace AU - Williams, Antony J AU - Little, Stephen B AU - Crofton, Kevin M AU - Thomas, Russell S AD - National Center for Computational Toxicology, Office of Research & Development, U.S. Environmental Protection Agency , Mail Code B205-01, Research Triangle Park, Durham, North Carolina 27711, United States. ; Center for Food Safety and Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States. ; Senior Environmental Employment Program, U.S. Environmental Protection Agency , Research Triangle Park, Durham, North Carolina 27711, United States. ; Molecular Networks GmbH , Henkestraße 91, 91052 Erlangen, Germany. ; Altamira, LLC , 1455 Candlewood Drive, Columbus, Ohio 43235, United States. ; ORISE Fellow, U.S. Environmental Protection Agency, Research Triangle Park, Durham, North Carolina 27711, United States. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 1225 EP - 1251 VL - 29 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811843913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=ToxCast+Chemical+Landscape%3A+Paving+the+Road+to+21st+Century+Toxicology.&rft.au=Richard%2C+Ann+M%3BJudson%2C+Richard+S%3BHouck%2C+Keith+A%3BGrulke%2C+Christopher+M%3BVolarath%2C+Patra%3BThillainadarajah%2C+Inthirany%3BYang%2C+Chihae%3BRathman%2C+James%3BMartin%2C+Matthew+T%3BWambaugh%2C+John+F%3BKnudsen%2C+Thomas+B%3BKancherla%2C+Jayaram%3BMansouri%2C+Kamel%3BPatlewicz%2C+Grace%3BWilliams%2C+Antony+J%3BLittle%2C+Stephen+B%3BCrofton%2C+Kevin+M%3BThomas%2C+Russell+S&rft.aulast=Richard&rft.aufirst=Ann&rft.date=2016-08-15&rft.volume=29&rft.issue=8&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00135 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00135 ER - TY - JOUR T1 - Pyrrolizidine Alkaloid-Protein Adducts: Potential Non-invasive Biomarkers of Pyrrolizidine Alkaloid-Induced Liver Toxicity and Exposure. AN - 1811843109; 27388689 AB - Pyrrolizidine alkaloids (PAs) are phytochemicals present in hundreds of plant species from different families widely distributed in many geographical regions around the world. PA-containing plants are probably the most common type of poisonous plants affecting livestock, wildlife, and humans. There have been many large-scale human poisonings caused by the consumption of food contaminated with toxic PAs. PAs require metabolic activation to generate pyrrolic metabolites to exert their toxicity. In this study, we developed a novel method to quantify pyrrole-protein adducts present in the blood. This method involves the use of AgNO3 in acidic ethanol to cleave the thiol linkage of pyrrole-protein (DHP-protein) adducts, and the resulting 7,9-di-C2H5O-DHP is quantified by HPLC-ES-MS/MS multiple reaction monitoring analysis in the presence of a known quantity of isotopically labeled 7,9-di-C2D5O-DHP internal standard. Using this method, we determined that diester-type PAs administered to rats produced higher levels of DHP-protein adducts than other types of PAs. The results suggest that DHP-protein adducts can potentially serve as minimally invasive biomarkers of PA exposure. JF - Chemical research in toxicology AU - Xia, Qingsu AU - Zhao, Yuewei AU - Lin, Ge AU - Beland, Frederick A AU - Cai, Lining AU - Fu, Peter P AD - National Center for Toxicological Research , Jefferson, Arkansas 72079, United States. ; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong , Hong Kong SAR. ; Biotranex LLC , Monmouth Junction, New Jersey 08852, United States. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 1282 EP - 1292 VL - 29 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811843109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Pyrrolizidine+Alkaloid-Protein+Adducts%3A+Potential+Non-invasive+Biomarkers+of+Pyrrolizidine+Alkaloid-Induced+Liver+Toxicity+and+Exposure.&rft.au=Xia%2C+Qingsu%3BZhao%2C+Yuewei%3BLin%2C+Ge%3BBeland%2C+Frederick+A%3BCai%2C+Lining%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2016-08-15&rft.volume=29&rft.issue=8&rft.spage=1282&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00120 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00120 ER - TY - JOUR T1 - Development and application of novel histochemical tracers for localizing brain connectivity and pathology. AN - 1808386537; 27155454 AB - A NEW FLUORESCENT RETROGRADE AXONAL TRACER WITH NUMEROUS UNIQUE PROPERTIES: A new fluorescent dye, Fluoro-Gold, has been demonstrated to undergo retrograde axonal transport. Its properties include (1) intense fluorescence, (2) extensive filling of dendrites, (3) high resistance to fading, (4) no uptake by intact undamaged fibers of passage, (5) no diffusion from labeled cells, (6) consistent and pure commercial source, (7) wide latitude of survival times and (8) compatibility with all other tested neuro-histochemical techniques. © 1986. Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons: The causes and effects of neuronal degeneration are of major interest to a wide variety of neuroscientists. Paralleling this growing interest is an increasing number of methods applicable to the detection of neuronal degeneration. The earliest methods employing aniline dyes were methodologically simple, but difficult to interpret due to a lack of staining specificity. In an attempt to circumvent this problem, numerous suppressed silver methods have been introduced. However, these methods are labor intensive, incompatible with most other histochemical procedures and notoriously capricious. In an attempt to develop a tracer with the methodological simplicity and reliability of conventional stains but with the specificity of an ideal suppressed silver preparation, the Fluoro-Jade dyes were developed. Fluoro-Jade C, like its predecessors, Fluoro-Jade and Fluoro-Jade B, was found to stain all degenerating neurons, regardless of specific insult or mechanism of cell death. Therefore, the patterns of neuronal degeneration seen following exposure to either the glutamate agonist, kainic acid, or the inhibitor of mitochondrial respiration, 3-NPA, were the same for all of the Fluoro-Jade dyes. However, there was a qualitative difference in the staining characteristics of the three fluorochromes. Specifically, Fluoro-Jade C exhibited the greatest signal to background ratio, as well as the highest resolution. This translates to a stain of maximal contrast and affinity for degenerating neurons. This makes it ideal for localizing not only degenerating nerve cell bodies, but also distal dendrites, axons and terminals. The dye is highly resistant to fading and is compatible with virtually all histological processing and staining protocols. Triple labeling was accomplished by staining degenerating neurons with Fluoro-Jade C, cell nuclei with DAPI and activated astrocytes with GFAP immunofluoresence. © 2005. The development of novel tracers and associated histochemical methods has always been need driven. One such need was the development of tracers that could be administered to discrete brain regions in vivo to subsequently reveal neuronal connectivity via axonal transport of the tracer. One such compound is Fluoro-Gold (F-G), which can be used to demonstrate retrograde axonal transport. Advantages of this fluorescent tracer include brightness, sensitivity, contrast, stability, permanence and compatibility with multiple labeling studies. It may be applied to resolve either the afferent or efferent connections of brain regions of interest. Another need addressed was for a simple and definitive way to localize degenerating neurons in brain tissue sections. This led to the development of Fluoro-Jade B (FJ-B) and Fluoro-Jade C (FJ-C). Advantages of these fluorescent histochemical tracers include high specificity, resolution, contrast, stability and suitability for use in multiple labeling studies. These methods can be applied to detect both apoptotic and necrotic neuronal degeneration following a variety of insults including physical trauma, neurodegenerative disease and a wide variety of neurotoxicants. This article is part of a Special Issue entitled SI:50th Anniversary Issue. Copyright © 2016. Published by Elsevier B.V. JF - Brain research AU - Schmued, Larry C AD - US Food and Drug Administration (FDA), National Center for Toxicological Research (NCTR), Division of Neurotoxicology, 3900 NCTR Rd, Jefferson, AR 72079United States. Electronic address: larry.schmued@fda.hhs.gov. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 31 EP - 35 VL - 1645 KW - Index Medicus KW - Neurotoxicants KW - Axonal transport KW - Fluoro-Jade C KW - Fluoro-Gold KW - Neuronal degeneration KW - Brain pathology KW - Neuronal connectivity KW - Axonal tract tracing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808386537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Development+and+application+of+novel+histochemical+tracers+for+localizing+brain+connectivity+and+pathology.&rft.au=Schmued%2C+Larry+C&rft.aulast=Schmued&rft.aufirst=Larry&rft.date=2016-08-15&rft.volume=1645&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2016.03.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.brainres.2016.03.053 ER - TY - JOUR T1 - Arsenic in private well water part 3 of 3: Socioeconomic vulnerability to exposure in Maine and New Jersey. AN - 1793903070; 27118035 AB - Arsenic is a naturally occurring toxic element often concentrated in groundwater at levels unsafe for human consumption. Private well water in the United States is mostly unregulated by federal and state drinking water standards. It is the responsibility of the over 13 million U.S. households regularly depending on private wells for their water to ensure it is safe for drinking. There is a consistent graded association with health outcomes at all levels of socioeconomic status (SES) in the U.S. Differential exposure to environmental risk may be contributing to this persistent SES-health gradient. Environmental justice advocates cite overwhelming evidence that income and other SES measures are consistently inversely correlated with exposure to suboptimal environmental conditions including pollutants, toxins, and their impacts. Here we use private well household surveys from two states to investigate the association between SES and risks for arsenic exposure, examining the potentially cumulative effects of residential location, testing and treatment behavior, and psychological factors influencing behavior. We find that the distribution of natural arsenic hazard in the environment is socioeconomically random. There is no evidence that higher SES households are avoiding areas with arsenic or that lower SES groups are disproportionately residing in areas with arsenic. Instead, disparities in exposure arise from differing rates of protective action, primarily testing well water for arsenic, and secondly treating or avoiding contaminated water. We observe these SES disparities in behavior as well as in the psychological factors that are most favorable to these behaviors. Assessment of risk should not be limited to the spatial occurrence of arsenic alone. It is important that social vulnerability factors are incorporated into risk modeling and identifying priority areas for intervention, which should include strategies that specifically target socioeconomically vulnerable groups as well as all the conditions which cause these disparities in testing and treatment behavior. Copyright © 2016 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Flanagan, Sara V AU - Spayd, Steven E AU - Procopio, Nicholas A AU - Marvinney, Robert G AU - Smith, Andrew E AU - Chillrud, Steven N AU - Braman, Stuart AU - Zheng, Yan AD - Columbia University, Lamont-Doherty Earth Observatory, 61 Route 9W, Palisades, NY 10964, USA; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th Street, New York, NY 10027, USA; New Jersey Department of Environmental Protection, P.O. Box 420, Trenton, NJ 08625-0420, USA. Electronic address: Flanagan@ldeo.columbia.edu. ; New Jersey Department of Environmental Protection, P.O. Box 420, Trenton, NJ 08625-0420, USA. Electronic address: Steve.Spayd@dep.nj.gov. ; New Jersey Department of Environmental Protection, P.O. Box 420, Trenton, NJ 08625-0420, USA. Electronic address: Nick.Procopio@dep.nj.gov. ; Maine Geological Survey, 93 State House Station, Augusta, ME 04333, USA. Electronic address: Robert.G.Marvinney@maine.gov. ; Maine Department of Health and Human Services, Maine Center for Disease Control and Prevention, 286 Water Street, Augusta, ME 04333, USA. Electronic address: Andy.E.Smith@maine.gov. ; Columbia University, Lamont-Doherty Earth Observatory, 61 Route 9W, Palisades, NY 10964, USA. Electronic address: Chilli@ldeo.columbia.edu. ; Columbia University, Lamont-Doherty Earth Observatory, 61 Route 9W, Palisades, NY 10964, USA. Electronic address: SBraman@ldeo.columbia.edu. ; Columbia University, Lamont-Doherty Earth Observatory, 61 Route 9W, Palisades, NY 10964, USA; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th Street, New York, NY 10027, USA; Queens College, City University of New York, 65-30 Kissena Blvd, Flushing, NY 11367, USA. Electronic address: YZheng@ldeo.columbia.edu. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 1019 EP - 1030 VL - 562 KW - Index Medicus KW - Arsenic KW - Private well KW - Environmental justice KW - Disparities KW - Socioeconomic status KW - Drinking water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793903070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Arsenic+in+private+well+water+part+3+of+3%3A+Socioeconomic+vulnerability+to+exposure+in+Maine+and+New+Jersey.&rft.au=Flanagan%2C+Sara+V%3BSpayd%2C+Steven+E%3BProcopio%2C+Nicholas+A%3BMarvinney%2C+Robert+G%3BSmith%2C+Andrew+E%3BChillrud%2C+Steven+N%3BBraman%2C+Stuart%3BZheng%2C+Yan&rft.aulast=Flanagan&rft.aufirst=Sara&rft.date=2016-08-15&rft.volume=562&rft.issue=&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2016.03.217 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2016.03.217 ER - TY - JOUR T1 - Editorial: Promising approaches to identify DILI drugs. AN - 1803115162; 27393768 JF - Chemico-biological interactions AU - Li, Albert P AU - Zhang, Jie AD - In Vitro ADMET Laboratories Inc., Columbia, MD, USA. Electronic address: liabert@invitroadmet.com. ; The National Center for Toxicological Research U. S. Food and Drug Administration, Jefferson, AR, USA. Electronic address: Jie.Zhang@fda.hhs.gov. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 1 EP - 2 VL - 255 KW - Pharmaceutical Preparations KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Pharmaceutical Preparations -- metabolism KW - Humans KW - Toxicity Tests -- methods KW - Cytochrome P-450 Enzyme System -- metabolism KW - Chemical and Drug Induced Liver Injury -- etiology KW - Drug Evaluation, Preclinical -- methods KW - Chemical and Drug Induced Liver Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803115162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Editorial%3A+Promising+approaches+to+identify+DILI+drugs.&rft.au=Li%2C+Albert+P%3BZhang%2C+Jie&rft.aulast=Li&rft.aufirst=Albert&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2016.06.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2016.06.021 ER - TY - JOUR T1 - Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse. AN - 1803112065; 27000539 AB - Interference of bile salt transport is one of the underlying mechanisms for drug-induced liver injury (DILI). We developed a novel bile salt transport activity assay involving in situ biosynthesis of bile salts from their precursors in primary human, monkey, dog, rat, and mouse hepatocytes in suspension as well as LC-MS/MS determination of extracellular bile salts transported out of hepatocytes. Glycine- and taurine-conjugated bile acids were rapidly formed in hepatocytes and effectively transported into the extracellular medium. The bile salt formation and transport activities were time‒ and bile-acid-concentration‒dependent in primary human hepatocytes. The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone. The assay was used to test 86 drugs for their potential to inhibit bile salt transport activity in human hepatocytes, which included 35 drugs associated with severe DILI (sDILI) and 51 with non-severe DILI (non-sDILI). Approximately 60% of the sDILI drugs showed potent inhibition (with IC50 values <50 μM), but only about 20% of the non-sDILI drugs showed this strength of inhibition in primary human hepatocytes and these drugs are associated only with cholestatic and mixed hepatocellular cholestatic (mixed) injuries. The sDILI drugs, which did not show substantial inhibition of bile salt transport activity, are likely to be associated with immune-mediated liver injury. Twenty-four drugs were also tested in monkey, dog, rat and mouse hepatocytes. Species differences in potency were observed with mouse being less sensitive than other species to inhibition of bile salt transport. In summary, a novel assay has been developed using hepatocytes in suspension from human and animal species that can be used to assess the potential for drugs and/or drug-derived metabolites to inhibit bile salt transport and/or formation activity. Drugs causing sDILI, except those by immune-mediated mechanism, are highly associated with potent inhibition of bile salt transport. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Zhang, Jie AU - He, Kan AU - Cai, Lining AU - Chen, Yu-Chuan AU - Yang, Yifan AU - Shi, Qin AU - Woolf, Thomas F AU - Ge, Weigong AU - Guo, Lei AU - Borlak, Jürgen AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: jie.zhang@fda.hhs.gov. ; Biotranex LLC, Monmouth Junction, NJ 08852, USA. Electronic address: khe@biotranex.com. ; Biotranex LLC, Monmouth Junction, NJ 08852, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 45 EP - 54 VL - 255 KW - ABCB11 protein, human KW - 0 KW - Bile Acids and Salts KW - Pharmaceutical Preparations KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Species difference KW - DILI KW - Hepatocytes KW - Bile salts KW - ABCB11 KW - Drug-induced liver injury KW - Bile salt export pump KW - BSEP KW - Young Adult KW - Animals KW - Humans KW - Tandem Mass Spectrometry -- methods KW - Aged KW - Mice KW - Haplorhini KW - Rats KW - Pharmaceutical Preparations -- metabolism KW - Cells, Cultured KW - Adenosine Triphosphate -- metabolism KW - Adult KW - Dogs KW - Cell Culture Techniques -- methods KW - Middle Aged KW - Adolescent KW - Drug Evaluation, Preclinical -- methods KW - Male KW - Female KW - Biological Transport, Active -- drug effects KW - Hepatocytes -- drug effects KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - ATP-Binding Cassette Transporters -- metabolism KW - Hepatocytes -- pathology KW - ATP-Binding Cassette Transporters -- antagonists & inhibitors KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Bile Acids and Salts -- metabolism KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803112065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Inhibition+of+bile+salt+transport+by+drugs+associated+with+liver+injury+in+primary+hepatocytes+from+human%2C+monkey%2C+dog%2C+rat%2C+and+mouse.&rft.au=Zhang%2C+Jie%3BHe%2C+Kan%3BCai%2C+Lining%3BChen%2C+Yu-Chuan%3BYang%2C+Yifan%3BShi%2C+Qin%3BWoolf%2C+Thomas+F%3BGe%2C+Weigong%3BGuo%2C+Lei%3BBorlak%2C+J%C3%BCrgen%3BTong%2C+Weida&rft.aulast=Zhang&rft.aufirst=Jie&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2016.03.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2016.03.019 ER - TY - JOUR T1 - The cytochrome P450 inhibitor SKF-525A disrupts autophagy in primary rat hepatocytes. AN - 1803111825; 26964495 AB - The cytochrome P450 (CYP) inhibitor SKF-525A is commonly used to study drug metabolism and toxicity, particularly hepatotoxicity. By using Western blot and immunofluorescence staining, we unexpectedly found that SKF-525A at 2-20 μM caused remarkable accumulation of microtubule-associated protein light chain 3 II (LC3-II) in primary rat hepatocytes at 1, 4 and 24 h, indicating that autophagy was disrupted. SKF-525A showed no effects on chloroquine induced LC3-II accumulation, suggesting that autophagic flux was blocked, which is further supported by the increased level of the p62 protein after SKF-525A treatment. SKF-525A did not affect proteasome activities or gene expression of LC3-II or p62. Immunofluorescence of green fluorescent protein fused lysosomal-associated membrane protein 1 (LAMP1, a specific protein marker for lysosomes) and LC3-II showed that co-localization of these two proteins was partially abolished by SKF-525A, indicating that autophagosome-lysosome fusion was blocked. The other five CYP inhibitors, metyrapone, 1-aminobenzotriazole, alpha-naphthoflavone, ticlopidine, and ketoconazole, showed no effects in parallel experiments. These findings provide novel insights into the mechanisms by which various CYP inhibitors differentially affect a same drug's toxicity in hepatocytes. The data also indicate that SKF-525A is not an ideal chemical inhibitor for probing the relation between CYP mediated metabolism and toxicity in primary hepatocytes. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Luo, Yong AU - Yang, Xi AU - Shi, Qiang AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: qiang.shi@fda.hhs.gov. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 55 EP - 62 VL - 255 KW - Cytochrome P-450 Enzyme Inhibitors KW - 0 KW - LC3 protein, rat KW - Microtubule-Associated Proteins KW - Proadifen KW - A510CA4CBT KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Hepatocyte KW - Autophagy KW - Cytochrome P450 KW - Hepatotoxicity KW - SKF-525A KW - Animals KW - Microtubule-Associated Proteins -- metabolism KW - Lysosomes -- pathology KW - Autophagosomes -- drug effects KW - Lysosomes -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Proteasome Endopeptidase Complex -- metabolism KW - Cells, Cultured KW - Membrane Fusion -- drug effects KW - Autophagosomes -- metabolism KW - Lysosomes -- drug effects KW - Autophagosomes -- pathology KW - Male KW - Autophagy -- drug effects KW - Hepatocytes -- drug effects KW - Cytochrome P-450 Enzyme Inhibitors -- toxicity KW - Proadifen -- toxicity KW - Hepatocytes -- pathology KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803111825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=The+cytochrome+P450+inhibitor+SKF-525A+disrupts+autophagy+in+primary+rat+hepatocytes.&rft.au=Luo%2C+Yong%3BYang%2C+Xi%3BShi%2C+Qiang&rft.aulast=Luo&rft.aufirst=Yong&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2016.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2016.03.007 ER - TY - JOUR T1 - Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity. AN - 1803111396; 26477383 AB - The generation of reactive metabolites from therapeutic agents is one of the major mechanisms of drug-induced liver injury (DILI). In order to evaluate metabolism-related toxicity and improve drug efficacy and safety, we generated a battery of HepG2-derived cell lines that express 14 cytochrome P450s (CYPs) (1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 3A4, 3A5 and 3A7) individually using a lentiviral expression system. The expression/production of a specific CYP in each cell line was confirmed by an increased abundance of the CYP at both mRNA and protein levels. Moreover, the enzymatic activities of representative CYPs in the corresponding cell lines were also measured. Using our CYP-expressed HepG2 cells, the toxicity of three drugs that could induce DILI (amiodarone, chlorpromazine and primaquine) was assessed, and all of them showed altered (increased or decreased) toxicity compared to the toxicity in drug-treated wild-type HepG2 cells. CYP-mediated drug toxicity examined in our cell system is consistent with previous reports, demonstrating the potential of these cells for assessing metabolism-related drug toxicity. This cell system provides a practical in vitro approach for drug metabolism screening and for early detection of drug toxicity. It is also a surrogate enzyme source for the enzymatic characterization of a particular CYP that contributes to drug-induced liver toxicity. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Xuan, Jiekun AU - Chen, Si AU - Ning, Baitang AU - Tolleson, William H AU - Guo, Lei AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of System Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Lei.Guo@fda.hhs.gov. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 63 EP - 73 VL - 255 KW - Antimalarials KW - 0 KW - Antipsychotic Agents KW - Cytochrome P-450 Enzyme Inhibitors KW - Protein Isoforms KW - RNA, Messenger KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Primaquine KW - MVR3634GX1 KW - Amiodarone KW - N3RQ532IUT KW - Chlorpromazine KW - U42B7VYA4P KW - Index Medicus KW - Drug metabolizing enzyme KW - HepG2 KW - Cytochrome P450s KW - Drug-induced liver toxicity KW - Antimalarials -- toxicity KW - Primaquine -- toxicity KW - Humans KW - Protein Isoforms -- metabolism KW - Gene Expression KW - RNA, Messenger -- genetics KW - Hep G2 Cells KW - Cytochrome P-450 Enzyme Inhibitors -- toxicity KW - Drug Evaluation, Preclinical -- methods KW - Protein Isoforms -- genetics KW - Chlorpromazine -- toxicity KW - Cell Line KW - Antipsychotic Agents -- toxicity KW - Liver -- pathology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Liver -- drug effects KW - Cytochrome P-450 Enzyme System -- genetics KW - Chemical and Drug Induced Liver Injury -- genetics KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Amiodarone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803111396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Development+of+HepG2-derived+cells+expressing+cytochrome+P450s+for+assessing+metabolism-associated+drug-induced+liver+toxicity.&rft.au=Xuan%2C+Jiekun%3BChen%2C+Si%3BNing%2C+Baitang%3BTolleson%2C+William+H%3BGuo%2C+Lei&rft.aulast=Xuan&rft.aufirst=Jiekun&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2015.10.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2015.10.009 ER - TY - JOUR T1 - Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles. AN - 1803111297; 26581450 AB - We report here the results of a collaborative research program to develop a robust and reliable in vitro system to allow an accurate definition of the drug-induced liver injury (DILI) potential of new drug entities during drug development. The in vitro hepatotoxic potential of 152 drugs with known DILI profiles were evaluated in primary cultured human hepatocytes with four mechanistically-relevant endpoints: cellular ATP depletion, reactive oxygen species (ROS), glutathione (GSH) depletion, and caspase activation for apoptosis. The drugs, 80 in the testing set and 72 in the validation set, were classified based on serious clinical/regulatory outcomes as defined by reported acute liver failure, black-box warning, and/or withdrawal. The drugs were further sub-categorized for dominant types of liver injury. Logistic regression models were performed to calculate the area under the receiver operating characteristics curve (AUROC) and to evaluate the prediction potential of the selected endpoints for serious clinical/regulatory outcomes. The ROS/ATP ratio was found to yield an excellent AUROC in both the testing (0.8989, P < 0.0001) and validation set (0.8545, P < 0.0001), and was found to distinguish drugs associated with severe from non-severe DILI cases (p < 0.0001). The results suggest that evaluation of drugs in primary human hepatocytes using the ROS/ATP ratio endpoint may aid the definition of their potential to cause severe DILI. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Chemico-biological interactions AU - Zhang, Jie AU - Doshi, Utkarsh AU - Suzuki, Ayako AU - Chang, Ching-Wei AU - Borlak, Jürgen AU - Li, Albert P AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, NCTR/FDA, Jefferson, AR, USA. ; In Vitro ADMET Laboratories LLC, Columbia, MD, USA. ; Division of Gastroenterology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA. ; Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. ; In Vitro ADMET Laboratories LLC, Columbia, MD, USA. Electronic address: lialbert@invitroadmet.com. ; Division of Bioinformatics and Biostatistics, NCTR/FDA, Jefferson, AR, USA. Electronic address: Weida.Tong@fda.hhs.gov. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 3 EP - 11 VL - 255 KW - Pharmaceutical Preparations KW - 0 KW - Reactive Oxygen Species KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Acute liver failure KW - Oxidative stress KW - In vitro toxicity testing KW - Drug induced liver injury KW - Drug development KW - Human hepatocytes KW - Young Adult KW - Liver -- pathology KW - Liver -- drug effects KW - Cells, Cultured KW - Humans KW - Glutathione -- metabolism KW - Liver -- metabolism KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Reactive Oxygen Species -- metabolism KW - Pharmaceutical Preparations -- metabolism KW - Hepatocytes -- drug effects KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Adenosine Triphosphate -- metabolism KW - Hepatocytes -- pathology KW - Drug Evaluation, Preclinical -- methods KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803111297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Evaluation+of+multiple+mechanism-based+toxicity+endpoints+in+primary+cultured+human+hepatocytes+for+the+identification+of+drugs+with+clinical+hepatotoxicity%3A+Results+from+152+marketed+drugs+with+known+liver+injury+profiles.&rft.au=Zhang%2C+Jie%3BDoshi%2C+Utkarsh%3BSuzuki%2C+Ayako%3BChang%2C+Ching-Wei%3BBorlak%2C+J%C3%BCrgen%3BLi%2C+Albert+P%3BTong%2C+Weida&rft.aulast=Zhang&rft.aufirst=Jie&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2015.11.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2015.11.008 ER - TY - JOUR T1 - Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk. AN - 1809603683; 27453575 AB - Genome-wide association studies (GWASs) have provided many insights into cancer genetics. However, the molecular mechanisms of many susceptibility SNPs defined by GWASs in cancer heritability and in promoting cancer risk remain elusive. New research strategies, including functional evaluations, are warranted to systematically explore truly causal genetic variants. In this study, we developed an integrative functional genomics methodology to identify cancer susceptibility SNPs in transcription factor-binding sites across the whole genome. Employing integration of functional genomic data from c-Myc cistromics, 1000 Genomes, and the TRANSFAC matrix, we successfully annotated 12 SNPs present in the c-Myc cistrome with properties consistent with modulating c-Myc binding affinity in hepatocellular carcinoma (HCC). After genotyping these 12 SNPs in 1,806 HBV-related HCC case subjects and 1,708 control subjects, we identified a HCC susceptibility SNP, rs157224G>T, in Chinese populations (T allele: odds ratio = 1.64, 95% confidence interval = 1.32-2.02; p = 5.2 × 10(-6)). This polymorphism leads to HCC predisposition through modifying c-Myc-mediated transcriptional regulation of EPB41, with the risk rs157224T allele showing significantly decreased gene expression. Based on cell proliferation, wound healing, and transwell assays as well as the mouse xenograft model, we identify EPB41 as a HCC susceptibility gene in vitro and in vivo. Consistent with this notion, we note that EPB41 expression is significantly decreased in HCC tissue specimens, especially in portal vein metastasis or intrahepatic metastasis, compared to normal tissues. Our results highlight the involvement of regulatory genetic variants in HCC and provide pathogenic insights of this malignancy via a genome-wide approach. Copyright © 2016 American Society of Human Genetics. All rights reserved. JF - American journal of human genetics AU - Yang, Xinyu AU - Yu, Dianke AU - Ren, Yanli AU - Wei, Jinyu AU - Pan, Wenting AU - Zhou, Changchun AU - Zhou, Liqing AU - Liu, Yu AU - Yang, Ming AD - Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. ; Clinical Laboratory, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China. ; Department of Radiation Oncology, Huaian No. 2 Hospital, Huaian, Jiangsu Province 223002, China. ; Department of Etiology and Carcinogenesis, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. ; Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China. Electronic address: aaryoung@yeah.net. Y1 - 2016/08/04/ PY - 2016 DA - 2016 Aug 04 SP - 275 EP - 286 VL - 99 IS - 2 KW - Index Medicus KW - EPB41 KW - susceptibility KW - HBV KW - genetic variant KW - c-Myc KW - HCC UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809603683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+human+genetics&rft.atitle=Integrative+Functional+Genomics+Implicates+EPB41+Dysregulation+in+Hepatocellular+Carcinoma+Risk.&rft.au=Yang%2C+Xinyu%3BYu%2C+Dianke%3BRen%2C+Yanli%3BWei%2C+Jinyu%3BPan%2C+Wenting%3BZhou%2C+Changchun%3BZhou%2C+Liqing%3BLiu%2C+Yu%3BYang%2C+Ming&rft.aulast=Yang&rft.aufirst=Xinyu&rft.date=2016-08-04&rft.volume=99&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=American+journal+of+human+genetics&rft.issn=1537-6605&rft_id=info:doi/10.1016%2Fj.ajhg.2016.05.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-04 N1 - Date revised - 2017-02-06 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1016/j.ajhg.2016.05.029 ER - TY - JOUR T1 - Survey of undeclared egg allergen levels in the most frequently recalled food types (including products bearing precautionary labelling) AN - 1827906312; PQ0003693530 AB - Since the number of recalls involving undeclared allergens is commonly associated with bakery and snack foods, we aimed to determine the frequency of egg allergens in a large number of these products using two commercial enzyme-linked immunosorbent assay (ELISA) methods. Samples were chosen that either had no egg identified on the product label or which had an egg precautionary statement. Among all samples, egg protein was detected in 5% of products using a Morinaga (MO) kit and 1% of products using a R-Biopharm (RB) kit. For bakery samples, egg protein was detected in 6% of 363 samples with no precautionary labelling (6% by MO and 1% by RB kit) and 12% of 80 samples which had precautionary labelling. For snack samples, egg protein was detected in 2% of 371 samples with no precautionary labelling (2% by MO and < 1% by RB kit) and 5% of 21 samples which had precautionary labelling. The disagreement rates between two methods were 5.2% for bakery products and 2.6% for snack products. The sample repeatability was at an acceptable level for bakery (< 12.5%) and snack foods (< 7.5%) for each method. The relative standard deviation between test kits was high (103.1%) for bakery foods. Four bakery products without precautionary labelling had a higher level of egg protein per serving compared with the eliciting dose (ED sub(10) of 3.7 mg protein) for egg allergic patients. These results highlight the fact that detection methodology plays a vital role for accurate labelling control and mitigation of risk for egg allergic consumers. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Khuda, Sefat E AU - Sharma, Girdhari M AU - Gaines, Dennis AU - Do, Andrew B AU - Pereira, Marion AU - Chang, Michael AU - Ferguson, Martine AU - Williams, Kristina M AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration (USFDA), 8301 Muirkirk Road, Laurel, MD 20708, USA Y1 - 2016/08/02/ PY - 2016 DA - 2016 Aug 02 SP - 1265 EP - 1273 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 8 SN - 1944-0049, 1944-0049 KW - Immunology Abstracts; Environment Abstracts KW - Risk assessment KW - Mitigation KW - Food additives KW - Allergens KW - Proteins KW - Immunoassays KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827906312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Survey+of+undeclared+egg+allergen+levels+in+the+most+frequently+recalled+food+types+%28including+products+bearing+precautionary+labelling%29&rft.au=Khuda%2C+Sefat+E%3BSharma%2C+Girdhari+M%3BGaines%2C+Dennis%3BDo%2C+Andrew+B%3BPereira%2C+Marion%3BChang%2C+Michael%3BFerguson%2C+Martine%3BWilliams%2C+Kristina+M&rft.aulast=Khuda&rft.aufirst=Sefat&rft.date=2016-08-02&rft.volume=33&rft.issue=8&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1198051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Mitigation; Allergens; Proteins; Immunoassays DO - http://dx.doi.org/10.1080/19440049.2016.1198051 ER - TY - JOUR T1 - Survey of undeclared soy allergen levels in the most frequently recalled food categories with or without precautionary labelling AN - 1827902856; PQ0003693531 AB - A comprehensive study was designed to determine the frequency and levels of soy allergen in packaged bakery and snack food products. A representative sample of products with no soy allergen disclosed on the label was analysed using two widely used enzyme-linked immunosorbent assay (ELISA) methods. Samples were chosen that either had no soy identified on the product label or which had a soy precautionary statement. Among 558 bakery and snack products, soy protein was detected in 17% of the products using the Neogen (NE) kit and 11% of the products using the Elisa Systems (ES) kit. The disagreement rates between kits were 8.8% for bakery products and 3.3% for snack products. Overall soy protein was detected at higher frequency in bakery products than in snack foods. Among 284 bakery samples, soy protein was detected in 25% of the samples with no precautionary statement and 19% of the samples which had a precautionary statement. Among 274 snack samples, soy protein was detected in 11% of the samples with no precautionary statement and 9% of the samples which had a precautionary statement. The sample repeatability was at an acceptable level ( 5 ppm) had a higher level of soy protein per serving compared with the eliciting dose sub(10) (ED sub(10)) of 10.6 mg for soy allergic patients. But the level of soy protein per serving may be clinically relevant to a subpopulation of soy allergic patients if a more stringent eliciting dose is applied. These findings emphasise that suitable detection methodologies and references doses are crucial for labelling accuracy and the safety of soy allergic consumers. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Khuda, Sefat E AU - Sharma, Girdhari M AU - Gaines, Dennis AU - Do, Andrew B AU - Pereira, Marion AU - Chang, Michael AU - Ferguson, Martine AU - Williams, Kristina M AD - Center for Food Safety and Applied Nutrition, United States Food and Drug Administration (USFDA), Laurel, MD, USA Y1 - 2016/08/02/ PY - 2016 DA - 2016 Aug 02 SP - 1274 EP - 1282 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 8 SN - 1944-0049, 1944-0049 KW - Immunology Abstracts; Environment Abstracts KW - Risk assessment KW - Food additives KW - Allergens KW - Subpopulations KW - Safety KW - Proteins KW - Immunoassays KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827902856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Survey+of+undeclared+soy+allergen+levels+in+the+most+frequently+recalled+food+categories+with+or+without+precautionary+labelling&rft.au=Khuda%2C+Sefat+E%3BSharma%2C+Girdhari+M%3BGaines%2C+Dennis%3BDo%2C+Andrew+B%3BPereira%2C+Marion%3BChang%2C+Michael%3BFerguson%2C+Martine%3BWilliams%2C+Kristina+M&rft.aulast=Khuda&rft.aufirst=Sefat&rft.date=2016-08-02&rft.volume=33&rft.issue=8&rft.spage=1274&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1207809 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Subpopulations; Allergens; Safety; Proteins; Immunoassays DO - http://dx.doi.org/10.1080/19440049.2016.1207809 ER - TY - JOUR T1 - The development and testing of a prototype mini-baghouse to control the release of respirable crystalline silica from sand movers AN - 1808664081; PQ0003402130 AB - Inhalation of respirable crystalline silica (RCS) is a significant risk to worker health during well completions operations (which include hydraulic fracturing) at conventional and unconventional oil and gas extraction sites. RCS is generated by pneumatic transfer of quartz-containing sand during hydraulic fracturing operations. National Institute for Occupational Safety and Health (NIOSH) researchers identified concentrations of RCS at hydraulic fracturing sites that exceed 10 times the Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (PEL) and up to 50 times the NIOSH Recommended Exposure Limit (REL). NIOSH research identified at least seven point sources of dust release at contemporary oil and gas extraction sites where RCS aerosols were generated. NIOSH researchers recommend the use of engineering controls wherever they can be implemented to limit the RCS released. A control developed to address one of the largest sources of RCS aerosol generation is the NIOSH mini-baghouse assembly, mounted on the thief hatches on top of the sand mover. This article details the results of a trial of the NIOSH mini-baghouse at a sand mine in Arkansas from November 18-21, 2013. During the trial, area air samples were collected at 12 locations on and around a sand mover with and without the mini-baghouse control installed. Analytical results for respirable dust and RCS indicate the use of the mini-baghouse effectively reduced both respirable dust and RCS downwind of the thief hatches. Reduction of airborne respirable dust ranged from 85-98%; reductions in airborne RCS ranged from 79-99%. A bulk sample of dust collected by the baghouse assembly showed the likely presence of freshly fractured quartz, a particularly hazardous form of RCS. Planned future design enhancements will increase the performance and durability of the mini-baghouse, including an improved bag clamp mechanism and upgraded filter fabric with a modified air-to-cloth ratio. Future trials are planned to determine additional respirable dust and RCS concentration reductions achieved through these design changes. JF - Journal of Occupational and Environmental Hygiene AU - Alexander, Barbara M AU - Esswein, Eric J AU - Gressel, Michael G AU - Kratzer, Jerry L AU - Feng, HAmy AU - King, Bradley AU - Miller, Arthur L AU - Cauda, Emanuele AD - National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio Y1 - 2016/08/02/ PY - 2016 DA - 2016 Aug 02 SP - 628 EP - 638 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 8 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Hydraulics KW - Prototypes KW - Occupational safety KW - Dust KW - Oil KW - Workers KW - Sand KW - Quartz KW - Air sampling KW - Baghouses KW - Pollution control equipment KW - Wind KW - Occupational exposure KW - Environmental hygiene KW - Aerosols KW - Oil and gas industry KW - Fractures KW - Mines KW - Filters KW - Fabrics KW - Silica KW - USA, Arkansas KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808664081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=The+development+and+testing+of+a+prototype+mini-baghouse+to+control+the+release+of+respirable+crystalline+silica+from+sand+movers&rft.au=Alexander%2C+Barbara+M%3BEsswein%2C+Eric+J%3BGressel%2C+Michael+G%3BKratzer%2C+Jerry+L%3BFeng%2C+HAmy%3BKing%2C+Bradley%3BMiller%2C+Arthur+L%3BCauda%2C+Emanuele&rft.aulast=Alexander&rft.aufirst=Barbara&rft.date=2016-08-02&rft.volume=13&rft.issue=8&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1168239 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Hydraulics; Aerosols; Fractures; Mines; Dust; Fabrics; Oil; Filters; Workers; Silica; Sand; Quartz; Occupational exposure; Environmental hygiene; Prototypes; Oil and gas industry; Occupational safety; Air sampling; Baghouses; Pollution control equipment; Wind; USA, Arkansas DO - http://dx.doi.org/10.1080/15459624.2016.1168239 ER - TY - JOUR T1 - Comparison of estimated core body temperature measured with the BioHarness and rectal temperature under several heat stress conditions AN - 1808660634; PQ0003402128 AB - Monitoring and measuring core body temperature is important to prevent or minimize physiological strain and cognitive dysfunction for workers such as first responders (e.g., firefighters) and military personnel. The purpose of this study is to compare estimated core body temperature (Tco-est), determined by heart rate (HR) data from a wearable chest strap physiology monitor, to standard rectal thermometry (Tre) under different conditions. Tco-est and Tre measurements were obtained in thermoneutral and heat stress conditions (high temperature and relative humidity) during four different experiments including treadmill exercise, cycling exercise, passive heat stress, and treadmill exercise while wearing personal protective equipment (PPE). Overall, the mean Tco-est did not differ significantly from Tre across the four conditions. During exercise at low-moderate work rates under heat stress conditions, Tco-est was consistently higher than Tre at all-time points. Tco-est underestimated temperature compared to Tre at rest in heat stress conditions and at a low work rate under heat stress while wearing PPE. The mean differences between the two measurements ranged from -0.1 plus or minus 0.4 to 0.3 plus or minus 0.4 degree C and Tco-est correlated well with HR (r = 0.795 - 0.849) and mean body temperature (r = 0.637 - 0.861). These results indicate that, the comparison of Tco-est to Tre may result in over- or underestimation which could possibly lead to heat-related illness during monitoring in certain conditions. Modifications to the current algorithm should be considered to address such issues. JF - Journal of Occupational and Environmental Hygiene AU - Seo, Yongsuk AU - DiLeo, Travis AU - Powell, Jeffrey B AU - Kim, Jung-Hyun AU - Roberge, Raymond J AU - Coca, Aitor AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, Pennsylvania Y1 - 2016/08/02/ PY - 2016 DA - 2016 Aug 02 SP - 612 EP - 620 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 8 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - High temperature KW - Physiology KW - Heart rate KW - Firefighter services KW - Heat tolerance KW - Temperature KW - Humidity KW - Military KW - Protective equipment KW - Working conditions KW - Occupational health KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808660634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Comparison+of+estimated+core+body+temperature+measured+with+the+BioHarness+and+rectal+temperature+under+several+heat+stress+conditions&rft.au=Seo%2C+Yongsuk%3BDiLeo%2C+Travis%3BPowell%2C+Jeffrey+B%3BKim%2C+Jung-Hyun%3BRoberge%2C+Raymond+J%3BCoca%2C+Aitor&rft.aulast=Seo&rft.aufirst=Yongsuk&rft.date=2016-08-02&rft.volume=13&rft.issue=8&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1161199 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - High temperature; Firefighter services; Heart rate; Physiology; Temperature; Heat tolerance; Humidity; Military; Protective equipment; Working conditions; Occupational health DO - http://dx.doi.org/10.1080/15459624.2016.1161199 ER - TY - JOUR T1 - Detecting bacteria contamination on medical device surfaces using an integrated fiber-optic mid-infrared spectroscopy sensing method AN - 1846410354; PQ0002968536 AB - Bacterial contamination on medical device surfaces is a critical public health concern. In order to detect bacteria on medical device surface, alternative methods for quantitative, accurate, easy-to-use, and real-time detection and identification of microorganism contamination are needed. We have recently presented a novel proof-of-concept platform for non-contact, label-free and real-time detection of surface contamination employing a fiber-optic Fourier transform infrared (FO-FTIR) spectroscopy sensing methodology in the mid-infrared (mid-IR) spectral range of 1.6-12 mu m. In the present study, we demonstrate the detection capability and sensitivity of the integrated FO-FTIR approach using four species of commonly encountered bacteria: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pneumoniae. FO-FTIR combined with multivariate approaches such as hierarchical clustering and principal component analysis provided specific mid-IR spectral differentiation of the four microorganisms including when the sample contained mixtures of bacteria types. To assess the sensitivity of the FO-FTIR platform, bacteria samples were prepared at 109 colony forming unit (CFU)/ mu L and then serially diluted 1:10 eight times. The salient findings of this investigation showed that the integrated FO-FTIR based sensor can detect the presence of the bacteria at concentrations between 103 and 104 CFU/2 mu L, producing unique bacteria signatures with high reproducibility. The advanced features of this sensing method in terms of sensitivity, specificity and repeatability employing non-contact, label-free, and real-time approaches, demonstrate its potential use as an alternative effective screening tool for routine monitoring of bacterial contaminated surfaces. JF - Sensors and Actuators B: Chemical AU - Hassan, Moinuddin AU - Gonzalez, Elizabeth AU - Hitchins, Victoria AU - Ilev, Ilko AD - Optical Therapeutics and Medical Nanophotonics Laboratory, Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 646 EP - 654 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 231 SN - 0925-4005, 0925-4005 KW - Microbiology Abstracts B: Bacteriology KW - Bacteria contamination KW - Fourier transform infrared (FTIR) spectroscopy KW - Fiber-optics sensors KW - Medical devices KW - Principal component analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846410354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sensors+and+Actuators+B%3A+Chemical&rft.atitle=Detecting+bacteria+contamination+on+medical+device+surfaces+using+an+integrated+fiber-optic+mid-infrared+spectroscopy+sensing+method&rft.au=Hassan%2C+Moinuddin%3BGonzalez%2C+Elizabeth%3BHitchins%2C+Victoria%3BIlev%2C+Ilko&rft.aulast=Hassan&rft.aufirst=Moinuddin&rft.date=2016-08-01&rft.volume=231&rft.issue=&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=Sensors+and+Actuators+B%3A+Chemical&rft.issn=09254005&rft_id=info:doi/10.1016%2Fj.snb.2016.03.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-07 DO - http://dx.doi.org/10.1016/j.snb.2016.03.044 ER - TY - JOUR T1 - Variable Lifting Index (VLI): A New Method for Evaluating Variable Lifting Tasks AN - 1827890587; PQ0003686888 AB - Objective: We seek to develop a new approach for analyzing the physical demands of highly variable lifting tasks through an adaptation of the Revised NIOSH (National Institute for Occupational Safety and Health) Lifting Equation (RNLE) into a Variable Lifting Index (VLI). Background: There are many jobs that contain individual lifts that vary from lift to lift due to the task requirements. The NIOSH Lifting Equation is not suitable in its present form to analyze variable lifting tasks. Method: In extending the prior work on the VLI, two procedures are presented to allow users to analyze variable lifting tasks. One approach involves the sampling of lifting tasks performed by a worker over a shift and the calculation of the Frequency Independent Lift Index (FILI) for each sampled lift and the aggregation of the FILI values into six categories. The Composite Lift Index (CLI) equation is used with lifting index (LI) category frequency data to calculate the VLI. The second approach employs a detailed systematic collection of lifting task data from production and/or organizational sources. The data are organized into simplified task parameter categories and further aggregated into six FILI categories, which also use the CLI equation to calculate the VLI. Results: The two procedures will allow practitioners to systematically employ the VLI method to a variety of work situations where highly variable lifting tasks are performed. Conclusions: The scientific basis for the VLI procedure is similar to that for the CLI originally presented by NIOSH; however, the VLI method remains to be validated. Application: The VLI method allows an analyst to assess highly variable manual lifting jobs in which the task characteristics vary from lift to lift during a shift. JF - Human Factors AU - Waters, Thomas AU - Occhipinti, Enrico AU - Colombini, Daniela AU - Alvarez-Casado, Enrique AU - Fox, Robert AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, epmenrico@tiscali.it Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 695 EP - 711 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 USA VL - 58 IS - 5 SN - 0018-7208, 0018-7208 KW - Health & Safety Science Abstracts KW - biomechanics KW - physical ergonomics KW - job analysis KW - manual materials handling KW - risk assessment KW - Adaptability KW - Occupational safety KW - Human factors KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827890587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Factors&rft.atitle=Variable+Lifting+Index+%28VLI%29%3A+A+New+Method+for+Evaluating+Variable+Lifting+Tasks&rft.au=Waters%2C+Thomas%3BOcchipinti%2C+Enrico%3BColombini%2C+Daniela%3BAlvarez-Casado%2C+Enrique%3BFox%2C+Robert&rft.aulast=Waters&rft.aufirst=Thomas&rft.date=2016-08-01&rft.volume=58&rft.issue=5&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Human+Factors&rft.issn=00187208&rft_id=info:doi/10.1177%2F0018720815612256 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 20 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Adaptability; Occupational safety; Human factors DO - http://dx.doi.org/10.1177/0018720815612256 ER - TY - JOUR T1 - Linear combination methods to improve diagnostic/prognostic accuracy on future observations AN - 1814271964 AB - Multiple diagnostic tests or biomarkers can be combined to improve diagnostic accuracy. The problem of finding the optimal linear combinations of biomarkers to maximise the area under the receiver operating characteristic curve has been extensively addressed in the literature. The purpose of this article is threefold: (1) to provide an extensive review of the existing methods for biomarker combination; (2) to propose a new combination method, namely, the nonparametric stepwise approach; (3) to use leave-one-pair-out cross-validation method, instead of re-substitution method, which is overoptimistic and hence might lead to wrong conclusion, to empirically evaluate and compare the performance of different linear combination methods in yielding the largest area under receiver operating characteristic curve. A data set of Duchenne muscular dystrophy was analysed to illustrate the applications of the discussed combination methods. JF - Statistical Methods in Medical Research AU - Kang, Le AU - Liu, Aiyi AU - Tian, Lili AD - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA ; Biostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA ; Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY, USA ; Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 1359 EP - 1380 CY - London PB - Sage Publications Ltd. VL - 25 IS - 4 SN - 0962-2802 KW - Medical Sciences KW - Multiple biomarkers KW - receiver operating characteristic curve KW - area under the receiver operating characteristic curve KW - linear combination KW - diagnostic/prognostic accuracy KW - Accuracy KW - Biological markers KW - Duchenne muscular dystrophy KW - Prognosis KW - Validation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814271964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Linear+combination+methods+to+improve+diagnostic%2Fprognostic+accuracy+on+future+observations&rft.au=Kang%2C+Le%3BLiu%2C+Aiyi%3BTian%2C+Lili&rft.aulast=Kang&rft.aufirst=Le&rft.date=2016-08-01&rft.volume=25&rft.issue=4&rft.spage=1359&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213481053 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2013 N1 - Last updated - 2016-08-27 DO - http://dx.doi.org/10.1177/0962280213481053 ER - TY - JOUR T1 - Statistical methods for multivariate meta-analysis of diagnostic tests: An overview and tutorial AN - 1814271426 AB - In this article, we present an overview and tutorial of statistical methods for meta-analysis of diagnostic tests under two scenarios: (1) when the reference test can be considered a gold standard and (2) when the reference test cannot be considered a gold standard. In the first scenario, we first review the conventional summary receiver operating characteristics approach and a bivariate approach using linear mixed models. Both approaches require direct calculations of study-specific sensitivities and specificities. We next discuss the hierarchical summary receiver operating characteristics curve approach for jointly modeling positivity criteria and accuracy parameters, and the bivariate generalized linear mixed models for jointly modeling sensitivities and specificities. We further discuss the trivariate generalized linear mixed models for jointly modeling prevalence, sensitivities and specificities, which allows us to assess the correlations among the three parameters. These approaches are based on the exact binomial distribution and thus do not require an ad hoc continuity correction. Lastly, we discuss a latent class random effects model for meta-analysis of diagnostic tests when the reference test itself is imperfect for the second scenario. A number of case studies with detailed annotated SAS code in MIXED and NLMIXED procedures are presented to facilitate the implementation of these approaches. JF - Statistical Methods in Medical Research AU - Ma, Xiaoye AU - Nie, Lei AU - Cole, Stephen R AU - Chu, Haitao AD - Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA ; Division of Biometrics IV, Office of Biometrics/OTS/CDER /FDA, Silver Spring, MD, USA ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA ; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 1596 EP - 1619 CY - London PB - Sage Publications Ltd. VL - 25 IS - 4 SN - 0962-2802 KW - Medical Sciences KW - Meta-analysis KW - diagnostic test KW - gold standard KW - generalized linear mixed models KW - Accuracy KW - Analysis KW - Approaches KW - Parameters KW - Positive affect KW - Random effects KW - Sensitivity KW - Statistical methods KW - Diagnostic tests KW - Binomial distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814271426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Statistical+methods+for+multivariate+meta-analysis+of+diagnostic+tests%3A+An+overview+and+tutorial&rft.au=Ma%2C+Xiaoye%3BNie%2C+Lei%3BCole%2C+Stephen+R%3BChu%2C+Haitao&rft.aulast=Ma&rft.aufirst=Xiaoye&rft.date=2016-08-01&rft.volume=25&rft.issue=4&rft.spage=1596&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213492588 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2013 N1 - Last updated - 2016-08-27 DO - http://dx.doi.org/10.1177/0962280213492588 ER - TY - JOUR T1 - Transmissible Plasmid Containing Salmonella enterica Heidelberg Isolates Modulate Cytokine Production During Early Stage of Interaction with Intestinal Epithelial Cells AN - 1811894240; PQ0003547551 AB - The variation in cytokine production during bacterial invasion of human intestinal epithelial cells (IECs) is a contributing factor for progression of the infection. A few Salmonella enterica Heidelberg strains isolated from poultry products harbor transmissible plasmids (TPs), including those that encode a type-IV secretion system. Earlier, we showed that these TPs are responsible for increased virulence during infection. This study examines the potential role of these TPs in cytokine production in IECs. This study showed that S. Heidelberg strains containing TPs (we refer as virulent strains) caused decreased interleukin (IL)-10 production in IECs after 1h infection. The virulent strains induced a high level of tumor necrosis factor- alpha production under identical conditions. The virulent strains of S. Heidelberg also altered the production of IL-2, IL-17, and granulocyte macrophage colony-stimulating factor compared to an avirulent strain. As a part of infection, bacteria cross the epithelial barrier and encounter intestinal macrophages. Hence, we examined the cytotoxic mechanism of strains of S. Heidelberg in macrophages. Scanning electron microscopy showed cell necrosis occurs during the early stage of infection. In conclusion, virulent S. Heidelberg strains were able to modify the host cytokine profile during the early stages of infection and also caused necrosis in macrophages. JF - DNA and Cell Biology AU - Gokulan, Kuppan AU - Khare, Sangeeta AU - Williams, Katherine AU - Foley, Steven L AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 443 EP - 453 PB - Mary Ann Liebert, Inc., 140 Huguenot Street New Rochelle NY 10801 United States VL - 35 IS - 8 SN - 1044-5498, 1044-5498 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Scanning electron microscopy KW - Epithelial cells KW - Poultry KW - Interleukin 2 KW - Granulocyte-macrophage colony-stimulating factor KW - Plasmids KW - Infection KW - Virulence KW - Cytotoxicity KW - Salmonella enterica KW - Interleukin 17 KW - Intestine KW - Cytokines KW - Tumor necrosis factor- alpha KW - J 02350:Immunology KW - N 14845:Miscellaneous KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811894240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+and+Cell+Biology&rft.atitle=Transmissible+Plasmid+Containing+Salmonella+enterica+Heidelberg+Isolates+Modulate+Cytokine+Production+During+Early+Stage+of+Interaction+with+Intestinal+Epithelial+Cells&rft.au=Gokulan%2C+Kuppan%3BKhare%2C+Sangeeta%3BWilliams%2C+Katherine%3BFoley%2C+Steven+L&rft.aulast=Gokulan&rft.aufirst=Kuppan&rft.date=2016-08-01&rft.volume=35&rft.issue=8&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=DNA+and+Cell+Biology&rft.issn=10445498&rft_id=info:doi/10.1089%2Fdna.2015.3142 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 63 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Scanning electron microscopy; Poultry; Interleukin 2; Granulocyte-macrophage colony-stimulating factor; Infection; Plasmids; Virulence; Cytotoxicity; Interleukin 17; Intestine; Cytokines; Tumor necrosis factor- alpha; Salmonella enterica DO - http://dx.doi.org/10.1089/dna.2015.3142 ER - TY - JOUR T1 - Exploration of testing practices and population characteristics support an increase in chlamydia positivity in Tasmania between 2001 and 2010 AN - 1811882020; PQ0003549707 AB - Objective: The proportion of positive chlamydia tests in young people in Tasmania increased significantly between 2001 and 2010. While female positivity rates increased steadily, male positivity rose steeply to 2005 then stabilised. Crude positivity rates can be influenced by a variety of factors making interpretation difficult. Unique Tasmanian datasets were used to explore whether symptom status, reason for testing or sexual exposure could explain the observed positivity trends. Methods: Population-level chlamydia positivity rates in Tasmania over a 10-year period were compared with surveillance data collected on people aged 15 to 29 years notified with chlamydia. Results: The proportion of asymptomatic chlamydia cases increased, with the largest increase in males aged 15 to 19 years (28%). Opportunistic testing of cases increased (greatest in males, range 17-32%). Sexual exposure remained consistent. Conclusions: After allowing for any changes in sexual exposure, symptom status and reason for testing, an increase in chlamydia positivity occurred over the 10 years. Healthcare providers have increased chlamydia testing in high-risk groups. Implications: Monitoring chlamydia testing patterns and positivity rates at a population level is a step forward in surveillance practices. Targeted surveys provide valuable information to supplement routine surveillance data. JF - Australian and New Zealand Journal of Public Health AU - Stephens, Nicola AU - Coleman, David AU - Shaw, Kelly AU - O'Sullivan, Maree AU - Vally, Hassan AU - Venn, Alison AD - Communicable Disease Epidemiology and Surveillance, Department of Health and Human Services Victoria. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 362 EP - 367 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 40 IS - 4 SN - 1326-0200, 1326-0200 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Data processing KW - Population characteristics KW - PSE, New Zealand KW - Risk groups KW - Population levels KW - PSE, Australia, Tasmania KW - Sexually transmitted diseases KW - Medical personnel KW - Chlamydia KW - Public health KW - J 02400:Human Diseases KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811882020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Australian+and+New+Zealand+Journal+of+Public+Health&rft.atitle=Exploration+of+testing+practices+and+population+characteristics+support+an+increase+in+chlamydia+positivity+in+Tasmania+between+2001+and+2010&rft.au=Stephens%2C+Nicola%3BColeman%2C+David%3BShaw%2C+Kelly%3BO%27Sullivan%2C+Maree%3BVally%2C+Hassan%3BVenn%2C+Alison&rft.aulast=Stephens&rft.aufirst=Nicola&rft.date=2016-08-01&rft.volume=40&rft.issue=4&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Australian+and+New+Zealand+Journal+of+Public+Health&rft.issn=13260200&rft_id=info:doi/10.1111%2F1753-6405.12502 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Data processing; Risk groups; Population levels; Public health; Population characteristics; Medical personnel; Sexually transmitted diseases; Chlamydia; PSE, New Zealand; PSE, Australia, Tasmania DO - http://dx.doi.org/10.1111/1753-6405.12502 ER - TY - JOUR T1 - Effects of Intertidal Harvest Practices on Levels of Vibrio parahaemolyticus and Vibrio vulnificus Bacteria in Oysters AN - 1811880442; PQ0003548963 AB - Vibrio parahaemolyticus and Vibrio vulnificus can grow rapidly in shellfish subjected to ambient air conditions, such as during intertidal exposure. In this study, levels of total and pathogenic (tdh+ and/or trh+) V. parahaemolyticus and total V. vulnificus were determined in oysters collected from two study locations where intertidal harvest practices are common. Samples were collected directly off intertidal flats, after exposure (ambient air [WashingtonState] or refrigerated [NewJersey]), and after reimmersion by natural tidal cycles. Samples were processed using a most-probable-number (MPN) real-time PCR method for total and pathogenic V. parahaemolyticus or V. vulnificus. In Washington State, the mean levels of V. parahaemolyticus increased 1.38 log MPN/g following intertidal exposure and dropped 1.41 log MPN/g after reimmersion for 1 day, but the levels were dependent upon the container type utilized. Pathogenic V. parahaemolyticus levels followed a similar trend. However, V. vulnificus levels increased 0.10 log MPN/g during intertidal exposure in Washington but decreased by >1 log MPN/g after reimmersion. In New Jersey, initial levels of all vibrios studied were not significantly altered during the refrigerated sorting and containerizing process. However, there was an increase in levels after the first day of reimmersion by 0.79, 0.72, 0.92, and 0.71 log MPN/g for total, tdh+ and trh+ V. parahaemolyticus, and V. vulnificus, respectively. The levels of all targets decreased to those similar to background after a second day of reimmersion. These data indicate that the intertidal harvest and handling practices for oysters that were studied in Washington and New Jersey do not increase the risk of illness from V. parahaemolyticus or V. vulnificus. IMPORTANCE Vibrio parahaemolyticus and Vibrio vulnificus are the leading causes of seafood-associated infectious morbidity and mortality in the United States. Vibrio spp. can grow rapidly in shellfish subjected to ambient air conditions, such as during periods of intertidal exposure. When oysters are submersed with the incoming tide, the vibrios can be purged. However, data on the rates of increase and purging during intertidal harvest are scarce, which limits the accuracy of risk assessments. The objective of this study was to help fill these data gaps by determining the levels of total and pathogenic (tdh+ and/or trh+) V. parahaemolyticus and V. vulnificus in oysters from two locations where intertidal harvest practices are common, using the current industry practices. The data generated provide insight into the responses of Vibrio spp. to relevant practices of the industry and public health, which can be incorporated into risk management decisions. JF - Antimicrobial Agents & Chemotherapy AU - Jones, J L AU - Kinsey, T P AU - Johnson, L W AU - Porso, R AU - Friedman, B AU - Curtis, M AU - Wesighan, P AU - Schuster, R AU - Bowers, J C AD - << + $0, Jessica.Jones@fda.hhs.gov. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 4517 EP - 4522 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 15 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Risk assessment KW - Mortality KW - Vibrio KW - Data processing KW - Vibrio vulnificus KW - Vibrio parahaemolyticus KW - Polymerase chain reaction KW - Tides KW - Morbidity KW - Public health KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811880442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Effects+of+Intertidal+Harvest+Practices+on+Levels+of+Vibrio+parahaemolyticus+and+Vibrio+vulnificus+Bacteria+in+Oysters&rft.au=Jones%2C+J+L%3BKinsey%2C+T+P%3BJohnson%2C+L+W%3BPorso%2C+R%3BFriedman%2C+B%3BCurtis%2C+M%3BWesighan%2C+P%3BSchuster%2C+R%3BBowers%2C+J+C&rft.aulast=Jones&rft.aufirst=J&rft.date=2016-08-01&rft.volume=82&rft.issue=15&rft.spage=4517&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00721-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 30 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Data processing; Polymerase chain reaction; Morbidity; Tides; Public health; Vibrio; Vibrio vulnificus; Vibrio parahaemolyticus DO - http://dx.doi.org/10.1128/AEM.00721-16 ER - TY - JOUR T1 - Birth defects in infants born to employees of a microelectronics and business machine manufacturing facility. AN - 1811300414; 27224896 AB - Concerns about solvent releases from a microelectronics/business machine manufacturing facility in upstate New York led to interest in the health of former workers, including this investigation of birth defects in children of male and female employees. Children born 1983 to 2001 to facility employees were enumerated and matched to New York State's Congenital Malformations Registry. Reported structural birth defects were compared with numbers expected from state rates (excluding New York City), generating standardized prevalence ratios (SPRs). Exposure assessors classified employees as ever/never potentially exposed at the facility to metals, chlorinated hydrocarbons, and other hydrocarbons during windows critical to organogenesis (female workers) or spermatogenesis (male workers). Among workers, adjusted prevalence ratios were generated to evaluate associations between potential exposures and specific birth defects. External comparisons for structural defects were at expectation for infants of male workers (SPR = 1.01; 95% confidence interval [CI], 0.77-1.29; n = 60) and lower for births to female workers (SPR = 0.84; 95% CI, 0.50-1.33; n = 18). Among full-term infants of male workers, ventricular septal defects (VSDs) were somewhat elevated compared with the general population (SPR = 1.58; 95% CI, 0.99-2.39; n = 22). Within the cohort, potential paternal metal exposure was associated with increased VSD risk (adjusted prevalence ratio = 2.70; 95% CI, = 1.09-6.67; n = 7). While overall SPRs were near expectation, paternal exposure to metals (primarily lead) appeared to be associated with increased VSD risk in infants. Take-home of occupational exposures, nonoccupational exposures, and chance could not be ruled out as causes. Case numbers for many defects were small, limiting assessment of the role of occupational exposures. Birth Defects Research (Part A) 106:696-707, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Silver, Sharon R AU - Pinkerton, Lynne E AU - Rocheleau, Carissa M AU - Deddens, James A AU - Michalski, Adrian M AU - Van Zutphen, Alissa R AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio. ; New York State Department of Health, Bureau of Environmental and Occupational Epidemiology, Albany, New York. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 696 EP - 707 VL - 106 IS - 8 KW - Index Medicus KW - chlorinated hydrocarbons KW - metals KW - lead KW - congenital heart defects KW - occupational exposure KW - paternal exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811300414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Birth+defects+in+infants+born+to+employees+of+a+microelectronics+and+business+machine+manufacturing+facility.&rft.au=Silver%2C+Sharon+R%3BPinkerton%2C+Lynne+E%3BRocheleau%2C+Carissa+M%3BDeddens%2C+James+A%3BMichalski%2C+Adrian+M%3BVan+Zutphen%2C+Alissa+R&rft.aulast=Silver&rft.aufirst=Sharon&rft.date=2016-08-01&rft.volume=106&rft.issue=8&rft.spage=696&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23520 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23520 ER - TY - JOUR T1 - Regulation of striatal astrocytic receptor for advanced glycation end-products variants in an early stage of experimental Parkinson's disease. AN - 1810555325; 27221633 AB - Convincing evidence indicates that advanced glycation end-products and danger-associated protein S100B play a role in Parkinson's disease (PD). These agents operate through the receptor for advanced glycation end-products (RAGE), which displays distinct isoforms playing protective/deleterious effects. However, the nature of RAGE variants has been overlooked in PD studies. Hence, we attempted to characterize RAGE regulation in early stages of PD striatal pathology. A neurotoxin-based rodent model of PD was used in this study, through administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to C57BL/6 mice. Animals were killed 6 h post-MPTP to assess S100B/RAGE contents (RT-qPCR, ELISA) and RAGE isoform density (WB) and cellular distribution (immunohistochemistry). Dopaminergic and gliotic status were also mapped (HPLC-ED, WB, immunohistochemistry). At this preliminary stage of MPTP-induced PD in mice, RAGE inhibitory isoforms were increased whereas full-length RAGE was not affected. This putative cytoprotective RAGE phenotype paired an inflammatory and pro-oxidant setting fueling DAergic denervation. Increased RAGE inhibitory variants occur in astrocytes showing higher S100B density but no overt signs of hypertrophy or NF-κB activation, a canonical effector of RAGE. These findings expand our understanding of the toxic effect of MPTP on striatum and offer first in vivo evidence of RAGE being a responder in early stages of astrogliosis dynamics, supporting a protective rather tissue-destructive phenotype of RAGE in the initial phase of PD degeneration. These data lay the groundwork for future studies on the relevance of astrocytic RAGE in DAergic neuroprotection strategies. We report increased antagonistic RAGE variants paralleling S100B up-regulation in early stages of MPTP-induced astrogliosis dynamics . We propose that selective RAGE regulation reflects a self-protective mechanism to maintain low levels of RAGE ligands , preventing long-term inflammation and oxidative stress arising from sustained ligands/flRAGE activation . Understanding loss of RAGE protective response to stress may provide new therapeutic options to halt or slow down dopaminergic axonopathy and, ultimately, neuronal death . © 2016 International Society for Neurochemistry. JF - Journal of neurochemistry AU - Viana, Sofia D AU - Valero, Jorge AU - Rodrigues-Santos, Paulo AU - Couceiro, Patrícia AU - Silva, Andréa M AU - Carvalho, Félix AU - Ali, Syed F AU - Fontes-Ribeiro, Carlos A AU - Pereira, Frederico C AD - Laboratory of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. ; CNC.IBILI - University of Coimbra, Coimbra, Portugal. ; Institute of Immunology - Faculty of Medicine, University of Coimbra, Coimbra, Portugal. ; Immunology and Oncology Laboratory, Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal. ; UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center of Toxicological Research/Food and Drug Administration, Jefferson, Arkansas, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 598 EP - 609 VL - 138 IS - 4 KW - Index Medicus KW - S100B KW - MPTP KW - striatum KW - RAGE isoforms KW - astrocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1810555325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Regulation+of+striatal+astrocytic+receptor+for+advanced+glycation+end-products+variants+in+an+early+stage+of+experimental+Parkinson%27s+disease.&rft.au=Viana%2C+Sofia+D%3BValero%2C+Jorge%3BRodrigues-Santos%2C+Paulo%3BCouceiro%2C+Patr%C3%ADcia%3BSilva%2C+Andr%C3%A9a+M%3BCarvalho%2C+F%C3%A9lix%3BAli%2C+Syed+F%3BFontes-Ribeiro%2C+Carlos+A%3BPereira%2C+Frederico+C&rft.aulast=Viana&rft.aufirst=Sofia&rft.date=2016-08-01&rft.volume=138&rft.issue=4&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fjnc.13682 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/jnc.13682 ER - TY - JOUR T1 - Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts. AN - 1809046512; 27082013 AB - Exposure to bisphenol A (BPA) has been reported to alter global gene expression, induce epigenetic modifications, and interfere with complex regulatory networks of cells. In addition to these reprogramming events, we have demonstrated that BPA exposure generates reactive oxygen species and promotes cellular survival when co-exposed with the oxidizing agent potassium bromate (KBrO3). We determined the cellular microenvironment changes induced by co-exposure of BPA and KBrO3 versus either agent alone. Ku70-deficient cells were exposed to 150 μM BPA, 20 mM KBrO3, or co-exposed to both agents. Four and 24 hr post-damage initiation by KBrO3, with BPA-only samples timed to coincide with these designated time points, we performed whole-genome microarray analysis and evaluated chromatin structure, DNA lesion load, glutathione content, and intracellular pH. We found that 4 hr post-damage initiation, BPA exposure and co-exposure transiently condensed chromatin compared with untreated and KBrO3-only treated cells; the transcription of DNA repair proteins was also reduced. At this time point, BPA exposure and co-exposure also reduced the change in intracellular pH observed after treatment with KBrO3 alone. Twenty-four hours post-damage initiation, BPA-exposed cells showed less condensed chromatin than cells treated with KBrO3 alone; the intracellular pH of the co-exposed cells was significantly reduced compared with untreated and KBrO3-treated cells; and significant up-regulation of DNA repair proteins was observed after co-exposure. These results support the induction of an adaptive response by BPA co-exposure that alters the microcellular environment and modulates DNA repair. Further work is required to determine whether BPA induces similar DNA lesions in vivo at environmentally relevant doses; however, in the Ku70-deficient mouse embryonic fibroblasts, exposure to a high dose of BPA was associated with changes in the cellular microenvironment that may promote survival. Gassman NR, Coskun E, Jaruga P, Dizdaroglu M, Wilson SH. 2016. Combined effects of high-dose bisphenol A and oxidizing agent (KBrO3) on cellular microenvironment, gene expression, and chromatin structure of Ku70-deficient mouse embryonic fibroblasts. Environ Health Perspect 124:1241-1252; http://dx.doi.org/10.1289/EHP237. JF - Environmental health perspectives AU - Gassman, Natalie R AU - Coskun, Erdem AU - Jaruga, Pawel AU - Dizdaroglu, Miral AU - Wilson, Samuel H AD - Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1241 EP - 1252 VL - 124 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809046512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Combined+Effects+of+High-Dose+Bisphenol+A+and+Oxidizing+Agent+%28KBrO3%29+on+Cellular+Microenvironment%2C+Gene+Expression%2C+and+Chromatin+Structure+of+Ku70-deficient+Mouse+Embryonic+Fibroblasts.&rft.au=Gassman%2C+Natalie+R%3BCoskun%2C+Erdem%3BJaruga%2C+Pawel%3BDizdaroglu%2C+Miral%3BWilson%2C+Samuel+H&rft.aulast=Gassman&rft.aufirst=Natalie&rft.date=2016-08-01&rft.volume=124&rft.issue=8&rft.spage=1241&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2FEHP237 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/EHP237 ER - TY - JOUR T1 - Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data. AN - 1809046364; 26978842 AB - Diabetes and obesity are major threats to public health in the United States and abroad. Understanding the role that chemicals in our environment play in the development of these conditions is an emerging issue in environmental health, although identifying and prioritizing chemicals for testing beyond those already implicated in the literature is challenging. This review is intended to help researchers generate hypotheses about chemicals that may contribute to diabetes and to obesity-related health outcomes by summarizing relevant findings from the U.S. Environmental Protection Agency (EPA) ToxCast™ high-throughput screening (HTS) program. Our aim was to develop new hypotheses around environmental chemicals of potential interest for diabetes- or obesity-related outcomes using high-throughput screening data. We identified ToxCast™ assay targets relevant to several biological processes related to diabetes and obesity (insulin sensitivity in peripheral tissue, pancreatic islet and β cell function, adipocyte differentiation, and feeding behavior) and presented chemical screening data against those assay targets to identify chemicals of potential interest. The results of this screening-level analysis suggest that the spectrum of environmental chemicals to consider in research related to diabetes and obesity is much broader than indicated by research papers and reviews published in the peer-reviewed literature. Testing hypotheses based on ToxCast™ data will also help assess the predictive utility of this HTS platform. More research is required to put these screening-level analyses into context, but the information presented in this review should facilitate the development of new hypotheses. Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA. 2016. Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCast™ high-throughput data. Environ Health Perspect 124:1141-1154; http://dx.doi.org/10.1289/ehp.1510456. JF - Environmental health perspectives AU - Auerbach, Scott AU - Filer, Dayne AU - Reif, David AU - Walker, Vickie AU - Holloway, Alison C AU - Schlezinger, Jennifer AU - Srinivasan, Supriya AU - Svoboda, Daniel AU - Judson, Richard AU - Bucher, John R AU - Thayer, Kristina A AD - Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1141 EP - 1154 VL - 124 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809046364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Prioritizing+Environmental+Chemicals+for+Obesity+and+Diabetes+Outcomes+Research%3A+A+Screening+Approach+Using+ToxCast%E2%84%A2+High-Throughput+Data.&rft.au=Auerbach%2C+Scott%3BFiler%2C+Dayne%3BReif%2C+David%3BWalker%2C+Vickie%3BHolloway%2C+Alison+C%3BSchlezinger%2C+Jennifer%3BSrinivasan%2C+Supriya%3BSvoboda%2C+Daniel%3BJudson%2C+Richard%3BBucher%2C+John+R%3BThayer%2C+Kristina+A&rft.aulast=Auerbach&rft.aufirst=Scott&rft.date=2016-08-01&rft.volume=124&rft.issue=8&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1510456 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-03 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1289/ehp.1510456 ER - TY - JOUR T1 - Development and calibration of a dietary nitrate and nitrite database in the NIH-AARP Diet and Health Study AN - 1808735443; PQ0003406816 AB - Nitrate and nitrite are probable human carcinogens when ingested under conditions that increase the formation of N-nitroso compounds. There have been limited efforts to develop US databases of dietary nitrate and nitrite for standard FFQ. Here we describe the development of a dietary nitrate and nitrite database and its calibration. We analysed data from a calibration study of 1942 members of the NIH-AARP (NIH-AARP, National Institutes of Health-AARP) Diet and Health Study who reported all foods and beverages consumed on the preceding day in two non-consecutive 24 h dietary recalls (24HR) and completed an FFQ. Based on a literature review, we developed a database of nitrate and nitrite contents for foods reported on these 24HR and for food category line items on the FFQ. We calculated daily nitrate and nitrite intakes for both instruments, and used a measurement error model to compute correlation coefficients and attenuation factors for the FFQ-based intake estimates using 24HR-based values as reference data. FFQ-based median nitrate intake was 68.9 and 74.1 mg/d, and nitrite intake was 1.3 and 1.0 mg/d, in men and women, respectively. These values were similar to 24HR-based intake estimates. Energy-adjusted correlation coefficients between FFQ- and 24HR-based values for men and women respectively were 0.59 and 0.57 for nitrate and 0.59 and 0.58 for nitrite; energy-adjusted attenuation factors were 0.59 and 0.57 for nitrate and 0.47 and 0.38 for nitrite. The performance of the FFQ in assessing dietary nitrate and nitrite intakes is comparable to that for many other macro- and micronutrients. JF - Public Health Nutrition AU - Inoue-Choi, Maki AU - Virk-Baker, Mandeep K AU - Aschebrook-Kilfoy, Briseis AU - Cross, Amanda J AU - Subar, Amy F AU - Thompson, Frances E AU - Sinha, Rashmi AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9609 Medical Center Drive, 6E314, Rockville, MD 20850, USA, wardm@exchange.nih.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1934 EP - 1943 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 19 IS - 11 SN - 1368-9800, 1368-9800 KW - Health & Safety Science Abstracts; Calcium & Calcified Tissue Abstracts KW - Diets KW - Nitrate KW - Beverages KW - Data processing KW - Nitrates KW - Food KW - Carcinogens KW - Ingestion KW - Models KW - Public health KW - Databases KW - N-Nitroso compounds KW - Nitrites KW - Literature reviews KW - Micronutrients KW - Nitrite KW - Data bases KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808735443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Development+and+calibration+of+a+dietary+nitrate+and+nitrite+database+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Inoue-Choi%2C+Maki%3BVirk-Baker%2C+Mandeep+K%3BAschebrook-Kilfoy%2C+Briseis%3BCross%2C+Amanda+J%3BSubar%2C+Amy+F%3BThompson%2C+Frances+E%3BSinha%2C+Rashmi%3BWard%2C+Mary+H&rft.aulast=Inoue-Choi&rft.aufirst=Maki&rft.date=2016-08-01&rft.volume=19&rft.issue=11&rft.spage=1934&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS1368980015003407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 67 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Diets; Nitrate; Data processing; Beverages; Food; Carcinogens; Public health; Models; Databases; N-Nitroso compounds; Literature reviews; Micronutrients; Nitrite; Nitrates; Nitrites; Ingestion; Data bases DO - http://dx.doi.org/10.1017/S1368980015003407 ER - TY - JOUR T1 - Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys AN - 1808660572; PQ0003465635 AB - Nicotine, the main psychoactive component of tobacco, and (-)- Delta super(9)-tetrahydroca nnabinol (THC), the main psychoactive ingredient in cannabis, play major roles in tobacco and marijuana dependence as reinforcers of drug-seeking and drug-taking behavior. Drugs that act as inverse agonists of cannabinoid CB1 receptors in the brain can attenuate the rewarding and abuse-related effects of nicotine and THC, but their clinical use is hindered by potentially serious side effects. The recently developed CB1-receptor neutral antagonists may provide an alternative therapeutic approach to nicotine and cannabinoid dependence. Here we compare attenuation of nicotine and THC reinforcement and reinstatement in squirrel monkeys by the CB1-receptor inverse agonist rimonabant and by the recently developed CB1-receptor neutral antagonist AM4113. Both rimonabant and AM4113 reduced two effects of nicotine and THC that play major roles in tobacco and marijuana dependence: (1) maintenance of high rates of drug-taking behavior, and (2) priming- or cue-induced reinstatement of drug-seeking behavior in abstinent subjects (models of relapse). In contrast, neither rimonabant nor AM4113 modified cocaine-reinforced or food-reinforced operant behavior under similar experimental conditions. However, both rimonabant and AM4113 reduced cue-induced reinstatement in monkeys trained to self-administer cocaine, suggesting the involvement of a common cannabinoid-mediated mechanism in the cue-induced reinstatement for different drugs of abuse. These findings point to CB1-receptor neutral antagonists as a new class of medications for treatment of both tobacco dependence and cannabis dependence. JF - Neuropsychopharmacology AU - Schindler, Charles W AU - Redhi, Godfrey H AU - Vemuri, Kiran AU - Makriyannis, Alexandros AU - Le Foll, Bernard AU - Bergman, Jack AU - Goldberg, Steven R AU - Justinova, Zuzana AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 2283 EP - 2293 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 41 IS - 9 SN - 0893-133X, 0893-133X KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Inverse agonists KW - Operant conditioning KW - Food KW - Brain KW - Drug abuse KW - Reinstatement KW - Tetrahydrocannabinol KW - Saimiri KW - Drug dependence KW - Nicotine KW - Reinforcement KW - Cannabis KW - Tobacco KW - Drug addiction KW - Cannabinoid CB1 receptors KW - Cocaine KW - Side effects KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808660572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology&rft.atitle=Blockade+of+Nicotine+and+Cannabinoid+Reinforcement+and+Relapse+by+a+Cannabinoid+CB1-Receptor+Neutral+Antagonist+AM4113+and+Inverse+Agonist+Rimonabant+in+Squirrel+Monkeys&rft.au=Schindler%2C+Charles+W%3BRedhi%2C+Godfrey+H%3BVemuri%2C+Kiran%3BMakriyannis%2C+Alexandros%3BLe+Foll%2C+Bernard%3BBergman%2C+Jack%3BGoldberg%2C+Steven+R%3BJustinova%2C+Zuzana&rft.aulast=Schindler&rft.aufirst=Charles&rft.date=2016-08-01&rft.volume=41&rft.issue=9&rft.spage=2283&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/10.1038%2Fnpp.2016.27 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Inverse agonists; Operant conditioning; Food; Brain; Drug abuse; Reinstatement; Tetrahydrocannabinol; Drug dependence; Nicotine; Tobacco; Cannabis; Reinforcement; Cocaine; Cannabinoid CB1 receptors; Drug addiction; Side effects; Saimiri DO - http://dx.doi.org/10.1038/npp.2016.27 ER - TY - JOUR T1 - Reported work-related injuries and illnesses among Hispanic workers: Results from an emergency department surveillance system follow-back survey AN - 1808656984; PQ0003466166 AB - Background Research suggests Hispanic workers underreport injuries/illnesses to their employer. Methods The National Electronic Injury Surveillance System-occupational supplement was used to conduct a follow-back study of workers treated in emergency departments (EDs) from June 2012 through December 2013. Results An estimated 448,000 (95%CI 230,000-665,000) Hispanic workers treated in EDs for a work-related injury or illness were represented by 362 completed interviews. Of these, an estimated 443,000 (95%CI 228,000-657,000) workers reported the injury or illness to their employer or were self-employed. The majority had not heard of workers' compensation. Only 10% expected workers' compensation to cover their medical payment while 62% expected payment to be covered by their employer. Conclusion We characterized our respondent workforce who reported their injury or illness. We determined that NEISS-Work data are not the most appropriate source to capture underreporting of work-related injuries and illnesses to employers among Hispanic workers. Am. J. Ind. Med. 59:621-629, 2016. JF - American Journal of Industrial Medicine AU - Tonozzi, Theresa R AU - Marsh, Suzanne M AU - Reichard, Audrey A AU - Bhandari, Ruchi AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, Morgantown, West Virginia. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 621 EP - 629 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 8 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Workers' compensation KW - Injuries KW - Ethnic groups KW - Emergency medical services KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808656984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Reported+work-related+injuries+and+illnesses+among+Hispanic+workers%3A+Results+from+an+emergency+department+surveillance+system+follow-back+survey&rft.au=Tonozzi%2C+Theresa+R%3BMarsh%2C+Suzanne+M%3BReichard%2C+Audrey+A%3BBhandari%2C+Ruchi&rft.aulast=Tonozzi&rft.aufirst=Theresa&rft.date=2016-08-01&rft.volume=59&rft.issue=8&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22606 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Injuries; Ethnic groups; Emergency medical services DO - http://dx.doi.org/10.1002/ajim.22606 ER - TY - JOUR T1 - Reverse Integration in Wheelchair Basketball: A Serious Leisure Perspective AN - 1808650715; PQ0003413396 AB - Wheelchair basketball is one of the most popular sport activities among persons with disabilities. The current study focuses on "reverse integration" (RI) groups of athletes with and without disabilities playing wheelchair basketball in Israel. A qualitative analysis approach was chosen to examine whether the able-bodied participants in RI wheelchair basketball training and competition identify their participation as a "serious leisure" (SL) activity, and to determine which additional insights could be gained about this activity from participants' perspectives. Eight male able-bodied participants, who have taken part in three Israeli wheelchair basketball leagues (divisions), were interviewed. All eight participants in this study played longer than a year. The findings revealed support for the SL premise within all six SL criteria. Participation of our informants was categorized within the establishment and maintenance phases. All participants reported sustained perseverance in spite of having to deal with significant challenges, including the physical strain and mental difficulties associated with the game, coping with dual roles of participation as player and coach, and finally, having to face the same economical and social barriers typically reported by athletes with disability. JF - Journal of Sport and Social Issues AU - Hutzler, Yeshayahu AU - Barda, Rachel AU - Mintz, Ahuva AU - Hayosh, Tali AD - 1 .Zinman College for Physical Education and Sport Sciences, Netanya, Israel, shayke@wincol.ac.il Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 338 EP - 360 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 40 IS - 4 SN - 0193-7235, 0193-7235 KW - Physical Education Index KW - sport games KW - disability KW - inclusion KW - able-bodied KW - Handicapped KW - Integration KW - Participation KW - Leisure KW - Basketball KW - Activities KW - Perspective KW - Wheelchairs KW - Athletes KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808650715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Sport+and+Social+Issues&rft.atitle=Reverse+Integration+in+Wheelchair+Basketball%3A+A+Serious+Leisure+Perspective&rft.au=Hutzler%2C+Yeshayahu%3BBarda%2C+Rachel%3BMintz%2C+Ahuva%3BHayosh%2C+Tali&rft.aulast=Hutzler&rft.aufirst=Yeshayahu&rft.date=2016-08-01&rft.volume=40&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Journal+of+Sport+and+Social+Issues&rft.issn=01937235&rft_id=info:doi/10.1177%2F0193723516632043 LA - English DB - Physical Education Index N1 - Date revised - 2016-07-01 N1 - Number of references - 46 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Integration; Handicapped; Leisure; Participation; Basketball; Activities; Perspective; Athletes; Wheelchairs DO - http://dx.doi.org/10.1177/0193723516632043 ER - TY - JOUR T1 - Characterizing emergency department patients who reported work-related injuries and illnesses AN - 1808642574; PQ0003466167 AB - Background Per a Congressional directive and funding, this study describes worker and workplace characteristics of emergency department (ED) patients who reported their injury/illness to their employer. The study also responds to Congress's request to enumerate injured/ill self-employed workers and workers with chronic conditions. Methods We conducted a follow-back study on injured/ill workers, including self-employed, identified from a national ED surveillance system from June 2012 through December 2013. Results An estimated 3,357,000 (95%CI: 2,516,000-4,199,000) workers treated in EDs reported their injury/illness to their employer or were self-employed. Of those, 202,000 (95%CI: 133,000-272,000) had a chronic condition. Of all reporters, excluding self-employed, 77% indicated they received instructions as to whom to report. Conclusion The study did not identify underreporting issues and revealed that medical records data may not be appropriate for assessing underreporting. Additional research is needed to examine workplace characteristics that encourage injury and illness reporting. Am. J. Ind. Med. 59:610-620, 2016. JF - American Journal of Industrial Medicine AU - Bhandari, Ruchi AU - Marsh, Suzanne M AU - Reichard, Audrey A AU - Tonozzi, Theresa R AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, Morgantown, West Virginia. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 610 EP - 620 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 8 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Injuries KW - Congress KW - Emergency medical services KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808642574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Characterizing+emergency+department+patients+who+reported+work-related+injuries+and+illnesses&rft.au=Bhandari%2C+Ruchi%3BMarsh%2C+Suzanne+M%3BReichard%2C+Audrey+A%3BTonozzi%2C+Theresa+R&rft.aulast=Bhandari&rft.aufirst=Ruchi&rft.date=2016-08-01&rft.volume=59&rft.issue=8&rft.spage=610&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22607 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Injuries; Congress; Emergency medical services DO - http://dx.doi.org/10.1002/ajim.22607 ER - TY - JOUR T1 - Genetic Characterization of Cronobacter sakazakii Recovered from the Environmental Surveillance Samples During a Sporadic Case Investigation of Foodborne Illness AN - 1808641619; PQ0003358891 AB - Cronobacter sakazakii is an opportunistic human-pathogenic bacterium known to cause acute meningitis and necrotizing enterocolitis in neonates and immunocompromised individuals. This human-pathogenic microorganism has been isolated from a variety of food and environmental samples, and has been also linked to foodborne outbreaks associated with powdered infant formula (PIF). The U.S. Food and Drug Administration have a policy of zero tolerance of these organisms in PIF. Thus, this agency utilizes the presence of these microorganisms as one of the criteria in implementing regulatory actions and assessing adulteration of food products of public health importance. In this study, we recovered two isolates of Cronobacter from the 91 environmental swab samples during an investigation of sporadic case of foodborne illness following conventional microbiological protocols. The isolated typical colonies were identified using VITEK2 and real-time PCR protocols. The recovered Cronobacter isolates were then characterized for species identification by sequencing the 16S rRNA locus. Further, multilocus sequence typing (MLST) was accomplished characterizing seven known C. sakazakii-specific MLST loci (atpD, fusA, glnS, gltB, gyrB, infB, and pps). Results of this study confirmed all of the recovered Cronobacter isolates from the environmental swab samples to be C. sakazakii. The MLST profile matched with the published profile of the complex 31 of C. sakazakii. Thus, rRNA and 7-loci MLST-based sequencing protocols are robust techniques for rapid detection and differentiation of Cronobacter species, and these molecular diagnostic tools can be used in implementing successful surveillance program and in the control and prevention of foodborne illness. JF - Current Microbiology AU - Sulaiman, Irshad M AU - Jacobs, Emily AU - Segars, Katharine AU - Simpson, Steven AU - Kerdahi, Khalil AD - Southeast Regional Laboratory, U.S. Food and Drug Administration, 60, Eighth Street, Atlanta, GA, 30309, USA, Irshad.Sulaiman@fda.hhs.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 273 EP - 279 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 73 IS - 2 SN - 0343-8651, 0343-8651 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Infant formulas KW - DNA topoisomerase KW - Necrotizing enterocolitis KW - multilocus sequence typing KW - Meningitis KW - Public health KW - Differentiation KW - rRNA KW - Colonies KW - Microorganisms KW - Polymerase chain reaction KW - Neonates KW - rRNA 16S KW - G 07880:Human Genetics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808641619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Microbiology&rft.atitle=Genetic+Characterization+of+Cronobacter+sakazakii+Recovered+from+the+Environmental+Surveillance+Samples+During+a+Sporadic+Case+Investigation+of+Foodborne+Illness&rft.au=Sulaiman%2C+Irshad+M%3BJacobs%2C+Emily%3BSegars%2C+Katharine%3BSimpson%2C+Steven%3BKerdahi%2C+Khalil&rft.aulast=Sulaiman&rft.aufirst=Irshad&rft.date=2016-08-01&rft.volume=73&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Current+Microbiology&rft.issn=03438651&rft_id=info:doi/10.1007%2Fs00284-016-1059-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 43 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Infant formulas; DNA topoisomerase; Necrotizing enterocolitis; Public health; Meningitis; multilocus sequence typing; rRNA; Differentiation; Colonies; Microorganisms; Polymerase chain reaction; Neonates; rRNA 16S DO - http://dx.doi.org/10.1007/s00284-016-1059-z ER - TY - JOUR T1 - Mortality among workers exposed to toluene diisocyanate in the US polyurethane foam industry: Update and exposure-response analyses AN - 1808637979; PQ0003466168 AB - Background Mortality among 4,545 toluene diisocyante (TDI)-exposed workers was updated through 2011. The primary outcome of interest was lung cancer. Methods Life table analyses, including internal analyses by exposure duration and cumulative TDI exposure, were conducted. Results Compared with the US population, all cause and all cancer mortality was increased. Lung cancer mortality was increased but was not associated with exposure duration or cumulative TDI exposure. In post hoc analyses, lung cancer mortality was associated with employment duration in finishing jobs, but not in finishing jobs involving cutting polyurethane foam. Conclusions Dermal exposure, in contrast to inhalational exposure, to TDI is expected to be greater in finishing jobs and may play a role in the observed increase in lung cancer mortality. Limitations include the lack of smoking data, uncertainty in the exposure estimates, and exposure estimates that reflected inhalational exposure only. Am. J. Ind. Med. 59:630-643, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA JF - American Journal of Industrial Medicine AU - Pinkerton, Lynne E AU - Yiin, James H AU - Daniels, Robert D AU - Fent, Kenneth W AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 630 EP - 643 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 8 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Skin KW - Data processing KW - Life tables KW - Toluene KW - toluene diisocyanate KW - Employment KW - Foams KW - Cancer KW - Smoking KW - Workers KW - USA KW - Dose-response effects KW - polyurethane KW - Occupational exposure KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808637979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+among+workers+exposed+to+toluene+diisocyanate+in+the+US+polyurethane+foam+industry%3A+Update+and+exposure-response+analyses&rft.au=Pinkerton%2C+Lynne+E%3BYiin%2C+James+H%3BDaniels%2C+Robert+D%3BFent%2C+Kenneth+W&rft.aulast=Pinkerton&rft.aufirst=Lynne&rft.date=2016-08-01&rft.volume=59&rft.issue=8&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22622 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Skin; Toluene; Life tables; toluene diisocyanate; Foams; Workers; Smoking; Dose-response effects; polyurethane; Occupational exposure; Lung cancer; Employment; Cancer; USA DO - http://dx.doi.org/10.1002/ajim.22622 ER - TY - JOUR T1 - Using emergency department surveillance data to assess occupational injury and illness reporting by workers AN - 1808637817; PQ0003466172 AB - Objective Researchers from the National Institute for Occupational Safety and Health (NIOSH) share detailed methodologies from conducting two follow-back studies initiated in 2010 that were designed to assess whether workers reported their injuries and illnesses to their employers and to identify worker incentives and disincentives for reporting work-related injuries to employers. Methodology Study respondents were sampled from the National Electronic Injury Surveillance System occupational supplement (NEISS-Work), an emergency department-based surveillance system. Telephone interviews were used to collect information directly from workers. Outcomes Among persons treated in emergency departments who could be identified as working at the time of injury or illness, most reported their injury or illness to their employer. Our studies did not assess if these reported injuries and illnesses were recorded on the Occupational Safety and Health logs. Discussion Our approach suggests that emergency department-based surveillance data are limited in their utility to investigate underreporting among workers. Am. J. Ind. Med. 59:600-609, 2016. JF - American Journal of Industrial Medicine AU - Marsh, Suzanne M AU - Reichard, Audrey A AU - Bhandari, Ruchi AU - Tonozzi, Theresa R AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, Morgantown, West Virginia. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 600 EP - 609 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 8 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Workers KW - Data processing KW - Injuries KW - Occupational safety KW - Incentives KW - Emergency medical services KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808637817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Using+emergency+department+surveillance+data+to+assess+occupational+injury+and+illness+reporting+by+workers&rft.au=Marsh%2C+Suzanne+M%3BReichard%2C+Audrey+A%3BBhandari%2C+Ruchi%3BTonozzi%2C+Theresa+R&rft.aulast=Marsh&rft.aufirst=Suzanne&rft.date=2016-08-01&rf