TY - JOUR T1 - Pre-diagnosis insulin-like growth factor-I and risk of epithelial invasive ovarian cancer by histological subtypes: A collaborative re-analysis from the Ovarian Cancer Cohort Consortium. AN - 1869069415; 28205047 AB - PURPOSE Biologic evidence suggests that the Insulin-like growth factor (IGF)-family may be involved in the etiology of epithelial invasive ovarian cancer (EOC). However, prospective studies investigating the role of IGF-I in ovarian carcinogenesis have yielded conflicting results. METHODS We pooled and harmonized data from 6 case-control studies nested within the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis IGF-I concentrations and subsequent risk of EOC. We evaluated IGF-I concentrations and risk of EOC overall and by tumor subtype (defined by histology, grade, stage) in 1,270 cases and 2,907 matched controls. Multivariable conditional logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS Doubling of IGF-I concentration was associated with significantly lower risk of overall EOC [ORlog2 = 0.82; CI 0.72-0.93]. We observed no heterogeneity by tumor characteristics (e.g., histology, p het = 0.62), menopausal status at blood collection (p het = 0.79), or age at diagnosis (p het = 0.60). CONCLUSIONS These results suggest that IGF-I concentrations are inversely associated with EOC risk, independent of histological phenotype. Future prospective research should consider potential mechanisms for this association, including, considering other members of the IGF-family to better characterize the role of IGF-signaling in the etiology of EOC. JF - Cancer causes & control : CCC AU - Ose, Jennifer AU - Schock, Helena AU - Poole, Elizabeth M AU - Lehtinen, Matti AU - Visvanathan, Kala AU - Helzlsouer, Kathy AU - Buring, Julie E AU - Lee, I-Min AU - Tjønneland, Anne AU - Boutron-Ruault, Marie-Christine AU - Trichopoulou, Antonia AU - Mattiello, Amalia AU - Onland-Moret, N Charlotte AU - Weiderpass, Elisabete AU - Sánchez, María-José AU - Idahl, Annika AU - Travis, Ruth C AU - Rinaldi, Sabina AU - Merritt, Melissa A AU - Wentzensen, Nicolas AU - Tworoger, Shelley S AU - Kaaks, Rudolf AU - Fortner, Renée T AD - Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Baden-Württemberg, Germany. ; Channing Division of Network Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. ; Department of Laboratory Medicine, Karolinska Institutet, Huddinge, Sweden. ; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ; Division of Preventive Medicine, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA. ; Unit of Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark. ; Université Paris-Saclay, Université Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France. ; Hellenic Health Foundation, Athens, Greece. ; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. ; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. ; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. ; Escuela Andaluza de Salud Pública, Instituto de Investigación Biosanitaria ibs.GRANADA, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain. ; Department of Clinical Sciences, Obstetrics and Gynecology, Umea University, Umea, Sweden. ; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. ; Section of Nutrition and Metabolism, International Agency for Research on Cancer (IARC), Lyon, France. ; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. ; Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. ; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Baden-Württemberg, Germany. r.fortner@dkfz-heidelberg.de. Y1 - 2017/02/16/ PY - 2017 DA - 2017 Feb 16 KW - Developmental pathways KW - IGF-I KW - Histological subtypes KW - Epithelial ovarian cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1869069415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Pre-diagnosis+insulin-like+growth+factor-I+and+risk+of+epithelial+invasive+ovarian+cancer+by+histological+subtypes%3A+A+collaborative+re-analysis+from+the+Ovarian+Cancer+Cohort+Consortium.&rft.au=Ose%2C+Jennifer%3BSchock%2C+Helena%3BPoole%2C+Elizabeth+M%3BLehtinen%2C+Matti%3BVisvanathan%2C+Kala%3BHelzlsouer%2C+Kathy%3BBuring%2C+Julie+E%3BLee%2C+I-Min%3BTj%C3%B8nneland%2C+Anne%3BBoutron-Ruault%2C+Marie-Christine%3BTrichopoulou%2C+Antonia%3BMattiello%2C+Amalia%3BOnland-Moret%2C+N+Charlotte%3BWeiderpass%2C+Elisabete%3BS%C3%A1nchez%2C+Mar%C3%ADa-Jos%C3%A9%3BIdahl%2C+Annika%3BTravis%2C+Ruth+C%3BRinaldi%2C+Sabina%3BMerritt%2C+Melissa+A%3BWentzensen%2C+Nicolas%3BTworoger%2C+Shelley+S%3BKaaks%2C+Rudolf%3BFortner%2C+Ren%C3%A9e+T&rft.aulast=Ose&rft.aufirst=Jennifer&rft.date=2017-02-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=1573-7225&rft_id=info:doi/10.1007%2Fs10552-017-0852-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-02-16 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-17 DO - http://dx.doi.org/10.1007/s10552-017-0852-8 ER - TY - JOUR T1 - Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles. AN - 1867538710; 28187746 AB - BACKGROUND Concerns have been expressed that inhaled nanoparticles may behave differently to larger particles in terms of lung clearance and translocation, with potential implications for their toxicity. Studies undertaken to investigate this have typically involved limited post-exposure periods. There is a shortage of information on longer-term clearance and translocation patterns and their dependence on particle size, which this study aimed to address. METHODS Rats were exposed (<3 h) nose-only to aerosols of spark-generated radioactive iridium-192 nanoparticles of four sizes: 10 nm, 15 nm, 35 nm and 75 nm (count median diameter) (aerosol mass concentrations 17, 140, 430, and 690 μg/m3, respectively). The content of iridium-192 in the whole animal, organs, tissues, and excreta was measured at various times post-exposure to ≥ 1 month. Limited toxicological investigations were undertaken for the 10 nm aerosol using bronchoalveolar lavage fluid. Elemental maps of tissue samples were produced using laser ablation inductively coupled plasma mass spectrometry and synchrotron micro-focus x-ray fluorescence. The chemical speciation of the iridium was explored using synchrotron micro focus x-ray near-edge absorption spectroscopy. RESULTS Long-term lung retention half-times of several hundred days were found, which were not dependent on particle size. There was significant variation between individual animals. Analysis of bronchoalveolar lavage fluid for the 10 nm aerosol indicated a limited inflammatory response resolving within the first 7 days. Low levels of, particle size dependent, translocation to the kidney and liver were found (maximum 0.4% of the lung content). Any translocation to the brain was below the limits of detection (i.e. < 0.01% of the lung content). The kidney content increased to approximately 30 days and then remained broadly constant or decreased, whereas the content in the liver increased throughout the study. Laser ablation inductively coupled plasma mass spectrometry analysis indicated homogeneous iridium distribution in the liver and within the cortex in the kidney. CONCLUSIONS Slow lung clearance and a pattern of temporally increasing concentrations in key secondary target organs has been demonstrated for inhaled iridium aerosol particles < 100 nm, which may have implications for long-term toxicity, especially in the context of chronic exposures. JF - Particle and fibre toxicology AU - Buckley, Alison AU - Warren, James AU - Hodgson, Alan AU - Marczylo, Tim AU - Ignatyev, Konstantin AU - Guo, Chang AU - Smith, Rachel AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0RQ, UK. ; Diamond Light Source Ltd., Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, UK. ; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0RQ, UK. rachel.smith@phe.gov.uk. Y1 - 2017/02/10/ PY - 2017 DA - 2017 Feb 10 SP - 5 VL - 14 IS - 1 KW - Rat KW - Tissue distribution KW - Lung clearance KW - Toxicity KW - Inhalation exposure KW - In vivo study KW - Nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1867538710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Slow+lung+clearance+and+limited+translocation+of+four+sizes+of+inhaled+iridium+nanoparticles.&rft.au=Buckley%2C+Alison%3BWarren%2C+James%3BHodgson%2C+Alan%3BMarczylo%2C+Tim%3BIgnatyev%2C+Konstantin%3BGuo%2C+Chang%3BSmith%2C+Rachel&rft.aulast=Buckley&rft.aufirst=Alison&rft.date=2017-02-10&rft.volume=14&rft.issue=1&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2Fs12989-017-0185-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-02-11 N1 - Date revised - 2017-02-14 N1 - Last updated - 2017-02-14 DO - http://dx.doi.org/10.1186/s12989-017-0185-5 ER - TY - JOUR T1 - Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned with Heliotropium europaeum. AN - 1862767063; 28125883 AB - Pyrrolizidine alkaloids are among the most common poisonous plants affecting livestock, wildlife, and humans. Exposure of humans and livestock to toxic pyrrolizidine alkaloids through the intake of contaminated food and feed may result in poisoning, leading to devastating epidemics. During February 2014, 73 mixed breed female beef cows from the Galilee region of Israel were accidently fed pyrrolizidine alkaloid contaminated hay for 42 days, resulting in the sudden death of 24 cows over a period of 63 days. The remaining cows were slaughtered 2.5 months after the last ingestion of the contaminated hay. In this study, we report the histopathological analysis of the livers from five of the slaughtered cows and quantitation of pyrrolizidine alkaloid-derived DNA adducts from their livers and three livers of control cows fed with feed free of weeds producing pyrrolizidine alkaloids. Histopathological examination revealed that the five cows suffered from varying degrees of bile duct proliferation, fibrosis, and megalocytosis. Selected reaction monitoring HPLC-ES-MS/MS analysis indicated that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts were formed in all five livers. The livers from the three control cows did not have any liver damage nor any indication of DHP-DNA adduct formed. These results confirm that the toxicity observed in these cattle was caused by pyrrolizidine alkaloid poisoning and that pyrrolizidine alkaloid-derived DNA adducts could still be detected and quantified in the livers of the chronically poisoned cows 2.5 months after their last exposure to the contaminated feed, suggesting that DHP-derived DNA adducts can serve as biomarkers for pyrrolizidine alkaloid exposure and poisoning. JF - Chemical research in toxicology AU - Fu, Peter P AU - Xia, Qingsu AU - He, Xiaobo AU - Barel, Shimon AU - Edery, Nir AU - Beland, Frederick A AU - Shimshoni, Jakob A AD - National Center for Toxicological Research , Jefferson, Arkansas 72079, United States. ; Department of Toxicology, Kimron Veterinary Institute , 50250 Bet Dagan, Israel. ; Department of Pathology, Kimron Veterinary Institute , 50250 Bet Dagan, Israel. Y1 - 2017/02/10/ PY - 2017 DA - 2017 Feb 10 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862767063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Detection+of+Pyrrolizidine+Alkaloid+DNA+Adducts+in+Livers+of+Cattle+Poisoned+with+Heliotropium+europaeum.&rft.au=Fu%2C+Peter+P%3BXia%2C+Qingsu%3BHe%2C+Xiaobo%3BBarel%2C+Shimon%3BEdery%2C+Nir%3BBeland%2C+Frederick+A%3BShimshoni%2C+Jakob+A&rft.aulast=Fu&rft.aufirst=Peter&rft.date=2017-02-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00456 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-27 N1 - Date revised - 2017-02-13 N1 - Last updated - 2017-02-13 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00456 ER - TY - JOUR T1 - Pharmacokinetic Profile of Oral Cannabis in Humans: Blood and Oral Fluid Disposition and Relation to Pharmacodynamic Outcomes. AN - 1865528789; 28158482 JF - Journal of analytical toxicology AU - Vandrey, Ryan AU - Herrmann, Evan S AU - Mitchell, John M AU - Bigelow, George E AU - Flegel, Ronald AU - LoDico, Charles AU - Cone, Edward J AD - Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, 5510 Nathan Shock Dr., Baltimore, MD 21224, USA. ; Columbia University & the New York State Psychiatric Institute, 1051 Riverside Drive, Unit#120, New York, NY 10032, USA. ; RTI International, 3040 East Cornwallis Rd., Research Triangle Park, NC 27709, USA. ; Substance Abuse and Mental Health Services Administration (SAMHSA), Division of Workplace Programs (DWP), 5600 Fishers Lane, Rockville, MD 20857, USA. Y1 - 2017/02/03/ PY - 2017 DA - 2017 Feb 03 SP - 1 EP - 17 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1865528789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Pharmacokinetic+Profile+of+Oral+Cannabis+in+Humans%3A+Blood+and+Oral+Fluid+Disposition+and+Relation+to+Pharmacodynamic+Outcomes.&rft.au=Vandrey%2C+Ryan%3BHerrmann%2C+Evan+S%3BMitchell%2C+John+M%3BBigelow%2C+George+E%3BFlegel%2C+Ronald%3BLoDico%2C+Charles%3BCone%2C+Edward+J&rft.aulast=Vandrey&rft.aufirst=Ryan&rft.date=2017-02-03&rft.volume=&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbkx012 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-02-03 N1 - Date revised - 2017-02-07 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1093/jat/bkx012 ER - TY - JOUR T1 - Non-malignant respiratory disease among workers in industries using styrene-A review of the evidence AN - 1868327840; PQ0004034723 AB - Background Asthma and obliterative bronchiolitis (OB) cases have occurred among styrene-exposed workers. We aimed to investigate styrene as a risk factor for non-malignant respiratory disease (NMRD). Methods From a literature review, we identified case reports and assessed cross-sectional and mortality studies for strength of evidence of positive association (i.e., strong, intermediate, suggestive, none) between styrene exposure and NMRD-related morbidity and mortality. Results We analyzed 55 articles and two unpublished case reports. Ten OB cases and eight asthma cases were identified. Six (75%) asthma cases had abnormal styrene inhalation challenges. Thirteen (87%) of 15 cross-sectional studies and 12 (50%) of 24 mortality studies provided at least suggestive evidence that styrene was associated with NMRD-related morbidity or mortality. Six (66%) of nine mortality studies assessing chronic obstructive pulmonary disease-related mortality indicated excess mortality. Conclusions Available evidence suggests styrene exposure is a potential risk factor for NMRD. Additional studies of styrene-exposed workers are warranted. Am. J. Ind. Med. 60:163-180, 2017. JF - American Journal of Industrial Medicine AU - Nett, Randall J AU - Cox-Ganser, Jean M AU - Hubbs, Ann F AU - Ruder, Avima M AU - Cummings, Kristin J AU - Huang, Yuh-Chin T AU - Kreiss, Kathleen AD - Respiratory Health Division, Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 163 EP - 180 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 2 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868327840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Non-malignant+respiratory+disease+among+workers+in+industries+using+styrene-A+review+of+the+evidence&rft.au=Nett%2C+Randall+J%3BCox-Ganser%2C+Jean+M%3BHubbs%2C+Ann+F%3BRuder%2C+Avima+M%3BCummings%2C+Kristin+J%3BHuang%2C+Yuh-Chin+T%3BKreiss%2C+Kathleen&rft.aulast=Nett&rft.aufirst=Randall&rft.date=2017-02-01&rft.volume=60&rft.issue=2&rft.spage=163&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22655 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/ajim.22655 ER - TY - JOUR T1 - Cancer incidence among capacitor manufacturing workers exposed to polychlorinated biphenyls AN - 1868324402; PQ0004034724 AB - Background We evaluated cancer incidence in a cohort of polychlorinated biphenyl (PCB) exposed workers. Methods Incident cancers, identified using state registries, were compared to those in a national population using standardized incidence ratios. Trends in prostate cancer incidence with cumulative PCB exposure were evaluated using standardized rate ratios and Cox regression models. For selected sites, cumulative PCB exposure was compared between aggressive (fatal/distant stage) and localized/regional cancers. Results We identified 3,371 invasive first primary cancer diagnoses among 21,317 eligible workers through 2007. Overall relative incidence was reduced. Elevations were only observed for respiratory cancers and among women, urinary organ cancers. Among men, prostate cancer incidence was reduced and not associated with cumulative PCB exposure although median exposures were significantly higher for aggressive compared to localized/regional prostate cancers. Conclusion Previously observed associations between cumulative PCB exposure and prostate cancer mortality were not confirmed in this analysis; prostate cancer stage at diagnosis may explain the discrepancy. Am. J. Ind. Med. 60:198-207, 2017. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Ruder, Avima M AU - Hein, Misty J AU - Hopf, Nancy B AU - Waters, Martha A AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 198 EP - 207 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 2 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Workers KW - Invasiveness KW - polychlorinated biphenyls KW - Prostate cancer KW - Regression analysis KW - PCB KW - Models KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868324402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Cancer+incidence+among+capacitor+manufacturing+workers+exposed+to+polychlorinated+biphenyls&rft.au=Ruder%2C+Avima+M%3BHein%2C+Misty+J%3BHopf%2C+Nancy+B%3BWaters%2C+Martha+A&rft.aulast=Ruder&rft.aufirst=Avima&rft.date=2017-02-01&rft.volume=60&rft.issue=2&rft.spage=198&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22657 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Workers; Mortality; Invasiveness; Prostate cancer; polychlorinated biphenyls; Regression analysis; PCB; Models DO - http://dx.doi.org/10.1002/ajim.22657 ER - TY - JOUR T1 - The new ANSI nail gun standard: A lost opportunity for safety AN - 1868324140; PQ0004034725 AB - Pneumatic nail guns have been shown in published studies to cause injury and death to both workers and consumers, but those equipped with sequential trigger mechanisms provide much greater safety protection against unintentional discharge than those equipped with contact triggers. In 2015 the American National Standards Institute (ANSI) approved a revision to its 2002 nail gun standard, but failed to require sequential triggers. Substantive and procedural deficiencies in the ANSI standard's development process resulted in a scientifically unsound nail gun safety standard, detracting from its use as the basis for a mandatory national safety standard and ultimately from its ability to protect worker and consumer users. Am. J. Ind. Med. 60:147-151, 2017. JF - American Journal of Industrial Medicine AU - Howard, John AU - Branche, Christine M AU - Earnest, GScott AD - Office of the Director, National Institute for Occupational Safety and Health, Washington, District of Columbia. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 147 EP - 151 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 2 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868324140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=The+new+ANSI+nail+gun+standard%3A+A+lost+opportunity+for+safety&rft.au=Howard%2C+John%3BBranche%2C+Christine+M%3BEarnest%2C+GScott&rft.aulast=Howard&rft.aufirst=John&rft.date=2017-02-01&rft.volume=60&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22673 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/ajim.22673 ER - TY - JOUR T1 - Surface coating and matrix effect on the electrophoretic mobility of gold nanoparticles: a capillary electrophoresis-inductively coupled plasma mass spectrometry study AN - 1868323646; PQ0004063586 AB - Capillary electrophoresis (CE) is considered as a versatile technique in the size-based separation and speciation of nanomaterials. The electrophoretic mobility is determined by charge and size of an analyte which are affected by the surface composition of nanomaterials. Size-dependent differential electrophoretic mobility is used as a mechanism for size-based separation of nanoparticles. Understanding the effect of surface chemistry on the electrophoretic mobility of nanomaterials in CE is critical in obtaining accurate results in retention-based size calculation. A suite of gold nanoparticles (NPs) varied in sizes with different coatings, including citric acid (CA), lipoic acid (LA), tannic acid (TA), polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), branched polyethyleneimine (BPEI), and bovine serum albumin (BSA), were selected to evaluate their impact to the migration pattern of gold NPs. Additionally, surface-coated gold NPs dispersed in Suwannee River humic acid (SRHA) solution and fetal bovine serum (FBS) were used to investigate the matrix effect. It was found that the correlation between NP size and relative electrophoretic mobility is highly dependent on the capping agents. The matrix component in the SRHA solution only exhibited limited influence to the migration of NPs while electrophoretic behaviors were drastically altered in the presence of FBS matrix. JF - Analytical and Bioanalytical Chemistry AU - Qu, Haiou AU - Linder, Sean W AU - Mudalige, Thilak K AD - 0000 0001 2243 3366, grid.417587.8, Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA, Thilak.Mudalige@fda.hhs.gov Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 979 EP - 988 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 409 IS - 4 SN - 1618-2642, 1618-2642 KW - Biotechnology and Bioengineering Abstracts KW - Rivers KW - Speciation KW - polyvinylpyrrolidone KW - Electrophoretic mobility KW - Migration KW - Mass spectroscopy KW - Lipoic acid KW - polyethyleneimine KW - Bovine serum albumin KW - Humic acids KW - capillary electrophoresis KW - Gold KW - Tannic acid KW - Polyethylene glycol KW - nanoparticles KW - Citric acid KW - Coatings KW - nanotechnology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868323646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Surface+coating+and+matrix+effect+on+the+electrophoretic+mobility+of+gold+nanoparticles%3A+a+capillary+electrophoresis-inductively+coupled+plasma+mass+spectrometry+study&rft.au=Qu%2C+Haiou%3BLinder%2C+Sean+W%3BMudalige%2C+Thilak+K&rft.aulast=Qu&rft.aufirst=Haiou&rft.date=2017-02-01&rft.volume=409&rft.issue=4&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-016-0012-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Number of references - 37 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Rivers; Speciation; polyvinylpyrrolidone; Electrophoretic mobility; Migration; Lipoic acid; Mass spectroscopy; polyethyleneimine; Bovine serum albumin; Humic acids; capillary electrophoresis; Gold; Tannic acid; nanoparticles; Polyethylene glycol; nanotechnology; Coatings; Citric acid DO - http://dx.doi.org/10.1007/s00216-016-0012-0 ER - TY - JOUR T1 - The long persistence of pyrrolizidine alkaloid-derived DNA adducts in vivo: kinetic study following single and multiple exposures in male ICR mice AN - 1868322789; PQ0004095372 AB - Pyrrolizidine alkaloid (PA)-containing plants are widespread in the world and the most common poisonous plants affecting livestock, wildlife, and humans. Our previous studies demonstrated that PA-derived DNA adducts can potentially be a common biological biomarker of PA-induced liver tumor formation. In order to validate the use of these PA-derived DNA adducts as a biomarker, it is necessary to understand the basic kinetics of the PA-derived DNA adducts formed in vivo. In this study, we studied the dose-dependent response and kinetics of PA-derived DNA adduct formation and removal in male ICR mice orally administered with a single dose (40 mg/kg) or multiple doses (10 mg/kg/day) of retrorsine, a representative carcinogenic PA. In the single-dose exposure, the PA-derived DNA adducts exhibited dose-dependent linearity and persisted for up to 4 weeks. The removal of the adducts following a single-dose exposure to retrorsine was biphasic with half-lives of 9 h (t sub(1/2 alpha )) and 301 h (~12.5 days, t sub(1/2 beta )). In the 8-week multiple exposure study, a marked accumulation of PA-derived DNA adducts without attaining a steady state was observed. The removal of adducts after the multiple exposure also demonstrated a biphasic pattern but with much extended half-lives of 176 h (~7.33 days, t sub(1/2 alpha )) and 1736 h (~72.3 days, t sub(1/2 beta )). The lifetime of PA-derived DNA adducts was more than 8 weeks following the multiple-dose treatment. The significant persistence of PA-derived DNA adducts in vivo supports their role in serving as a biomarker of PA exposure. JF - Archives of Toxicology AU - Zhu, Lin AU - Xue, Junyi AU - Xia, Qingsu AU - Fu, Peter P AU - Lin, Ge AD - 0000 0004 1937 0482, grid.10784.3a, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China, peter.fu@fda.hhs.gov Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 949 EP - 965 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 91 IS - 2 SN - 0340-5761, 0340-5761 KW - Health & Safety Science Abstracts; Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868322789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=The+long+persistence+of+pyrrolizidine+alkaloid-derived+DNA+adducts+in+vivo%3A+kinetic+study+following+single+and+multiple+exposures+in+male+ICR+mice&rft.au=Zhu%2C+Lin%3BXue%2C+Junyi%3BXia%2C+Qingsu%3BFu%2C+Peter+P%3BLin%2C+Ge&rft.aulast=Zhu&rft.aufirst=Lin&rft.date=2017-02-01&rft.volume=91&rft.issue=2&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-016-1713-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Number of references - 62 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1007/s00204-016-1713-z ER - TY - JOUR T1 - Pioglitazone and bladder cancer: FDA's assessment AN - 1868321273; PQ0004093354 JF - Pharmacoepidemiology and Drug Safety AU - Hampp, Christian AU - Pippins, Jennifer AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 117 EP - 118 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 2 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868321273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Pioglitazone+and+bladder+cancer%3A+FDA%27s+assessment&rft.au=Hampp%2C+Christian%3BPippins%2C+Jennifer&rft.aulast=Hampp&rft.aufirst=Christian&rft.date=2017-02-01&rft.volume=26&rft.issue=2&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4154 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/pds.4154 ER - TY - JOUR T1 - A systematic review of pregnancy exposure registries: examination of protocol-specified pregnancy outcomes, target sample size, and comparator selection AN - 1868316088; PQ0004093353 AB - Purpose Our study sought to systematically evaluate protocol-specified study methodology in prospective pregnancy exposure registries including pre-specified pregnancy outcomes, power calculations for sample size, and comparator group selection. Methods U.S. pregnancy exposure registries designed to evaluate safety of drugs or biologics were identified from www.clinicaltrials.gov , the FDA's Office of Women's Health website, and the FDA's list of postmarketing studies. Protocols or similar documentation were obtained. Results We identified 35 U.S. registries for drugs or biologic use during pregnancy. All registries assessed risk for overall major congenital malformations. Pre-specified target enrollment was stated for 18 (51%) registries, and ranged from 150 to 500 exposed pregnancies (median 300). Thirty-two (91%) registries identified at least one comparison group, but only nine (26%) planned to use an internal comparator. The most common external comparator group (n=24, 69%) was the Metropolitan Atlanta Congenital Defects Program (MACDP). Conclusions No registries were designed to have sufficient power to assess specific malformations, despite the plausibility that most teratogens cause specific defects. Only half of the registries included a power analysis. Despite their common use, external comparators, including MACDP, have important limitations. In the absence of randomized controlled trial data in pregnant women, pregnancy registries remain an important tool as part of a comprehensive pregnancy surveillance program; however, pregnancy registries alone may not be sufficient to obtain adequate data regarding risks of specific malformations. JF - Pharmacoepidemiology and Drug Safety AU - Gelperin, Kate AU - Hammad, Hoda AU - Leishear, Kira AU - Bird, Steven T AU - Taylor, Lockwood AU - Hampp, Christian AU - Sahin, Leyla AD - U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER), Office of Surveillance and Epidemiology, Silver Spring, MD, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 208 EP - 214 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 2 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868316088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=A+systematic+review+of+pregnancy+exposure+registries%3A+examination+of+protocol-specified+pregnancy+outcomes%2C+target+sample+size%2C+and+comparator+selection&rft.au=Gelperin%2C+Kate%3BHammad%2C+Hoda%3BLeishear%2C+Kira%3BBird%2C+Steven+T%3BTaylor%2C+Lockwood%3BHampp%2C+Christian%3BSahin%2C+Leyla&rft.aulast=Gelperin&rft.aufirst=Kate&rft.date=2017-02-01&rft.volume=26&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4150 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/pds.4150 ER - TY - JOUR T1 - Drug availability adjustments in population-based studies of prescription opioid abuse AN - 1868310223; PQ0004093351 AB - Purpose Population-based prescription opioid abuse studies in which one drug is compared to another, or drugs are compared across time, often account for the availability of those drugs in the community. The objective of this investigation is to assess consistency in the relative abuse ratios (RARs) across different approaches for adjusting for drug availability. Methods For the years 2004 through 2010, RARs for each of four prescription opioids (hydrocodone, oxycodone, hydromorphone, and morphine) were calculated using negative binomial regression. Measures of abuse (outcome) were misuse/abuse-related emergency department visits obtained from the Drug Abuse Warning Network. Measures of drug availability (offsets) were drug utilization estimates obtained from IMS Health. Separate regression models were run using each of five measures of drug utilization: unique patients (URDD), prescriptions dispensed (RX), tablets dispensed (TD), kilograms (KGs) sold, and morphine-equivalents (MEs) of kilograms sold. These results were compared for consistency. Results Aside from oxycodone-combination products, across molecules, RARs adjusted by RXs, TDs, and URDDs were generally similar to each other while RARs adjusted by KGs and MEs were different. For example, compared to hydrocodone, oxycodone had statistically significantly increased RARs of 3.6 (95%CI: 2.0-6.5), 3.5 (95%CI: 1.9-6.4), and 2.7 (95%CI: 1.5-5.0) when adjusted by URDDs, RXs, and TDs, respectively, but not when adjusted by KGs or MEs. Conclusions Different drug utilization adjustment approaches may yield inconsistent RAR estimates in population-based prescription opioid abuse analyses. JF - Pharmacoepidemiology and Drug Safety AU - Secora, Alex AU - Trinidad, James Phillip AU - Zhang, Rongmei AU - Gill, Rajdeep AU - Dal Pan, Gerald AD - Office of Surveillance and Epidemiology, Division of Epidemiology, Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 180 EP - 191 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 2 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868310223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Drug+availability+adjustments+in+population-based+studies+of+prescription+opioid+abuse&rft.au=Secora%2C+Alex%3BTrinidad%2C+James+Phillip%3BZhang%2C+Rongmei%3BGill%2C+Rajdeep%3BDal+Pan%2C+Gerald&rft.aulast=Secora&rft.aufirst=Alex&rft.date=2017-02-01&rft.volume=26&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4139 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/pds.4139 ER - TY - JOUR T1 - Rapid Testing of Food Matrices for Bacillus cereus Enterotoxins AN - 1868306184; PQ0004035381 AB - Nine different food products frequently associated with Bacillus cereus outbreaks were chosen as representative matrices to be evaluated with end-point polymerase chain reaction (PCR), enzyme linked immunosorbent assay, lateral flow device and mass spectrometry for detection of enterotoxins associated with human illness. Testing was performed on food portions inoculated with a bacterial strain and incubated at 30 degree C for either 5 h or 24 h. A screening end-point multiplex PCR targeting enterotoxin genes including the emetic toxin and three diarrheal toxins, hemolytic hemolysin BL (Hbl), nonhemoltyic enterotoxin (Nhe), and cytolysin K. Commercially available kits were used to determine the presence/absence of Nhe and Hbl. Finally; a quantitative analysis using mass spectrometry was performed for the detection of the emetic toxin. Definitive results were available after a five hour pre-enrichment in five food products. The following strategy would allow for more efficient testing of surveillance or environmental samples as well as more rapid response time during a foodborne outbreak. Practical Applications The application of a strategy for processing and analyzing food products for Bacillus cereus and the enterotoxins associated with foodborne illness was explored. Employment of such a strategy will decrease time spent processing negative samples allowing more time for analysis of potentially positive food products. JF - Journal of Food Safety AU - Tallent, Sandra M AU - Hait, Jennifer M AU - Knolhoff, Ann M AU - Bennett, Reginald W AU - Hammack, Thomas S AU - Croley, Timothy R AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD, 20740. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - [np] PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 37 IS - 1 SN - 0149-6085, 0149-6085 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868306184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Effects+of+subchronic+exposure+of+silver+nanoparticles+on+intestinal+microbiota+and+gut-associated+immune+responses+in+the+ileum+of+Sprague-Dawley+rats&rft.au=Williams%2C+Katherine%3BMilner%2C+Jessica%3BBoudreau%2C+Mary+D%3BGokulan%2C+Kuppan%3BCerniglia%2C+Carl+E%3BKhare%2C+Sangeeta&rft.aulast=Williams&rft.aufirst=Katherine&rft.date=2015-05-01&rft.volume=9&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2014.921346 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1111/jfs.12292 ER - TY - JOUR T1 - Flow-Cytometry-Based Method to Detect Escherichia coli and Shigella Spp. Using 16S rRNA-Based Probe. AN - 1863711267; 28146281 AB - Detection of microbial contamination in foods before they go on to the market can help prevent the occurrence of foodborne illness outbreaks. Current methods for the detection of Escherichia coli are limited by time-consuming procedures, which include multiple culture incubation steps, and require several days to get results. This unit describes the development of an improved rapid flow-cytometry-based detection method that has greater sensitivity and specificity. This method requires less time-to-results (TTR) and can detect a small number of E. coli in the presence of large numbers of other bacteria. Clear step-by-step protocols for cell concentration determination, sample preparation, and flow cytometric analysis are provided. © 2017 by John Wiley & Sons, Inc. Copyright © 2017 John Wiley & Sons, Inc. JF - Current protocols in toxicology AU - Xue, Yong AU - Wilkes, Jon G AU - Moskal, Ted J AU - Williams, Anna J AU - Cooper, Willie M AU - Buzatu, Dan A AD - Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. ; Life Sciences Consultant, Jonesboro, Arkansas. Y1 - 2017/02/01/ PY - 2017 DA - 2017 Feb 01 SP - 2.25.1 EP - 2.25.8 VL - 71 KW - microbial contamination KW - oligonucleotide probe KW - Escherichia coli KW - Shigella KW - flow cytometry KW - Salmonella KW - foodborne illness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1863711267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+protocols+in+toxicology&rft.atitle=Flow-Cytometry-Based+Method+to+Detect+Escherichia+coli+and+Shigella+Spp.+Using+16S+rRNA-Based+Probe.&rft.au=Xue%2C+Yong%3BWilkes%2C+Jon+G%3BMoskal%2C+Ted+J%3BWilliams%2C+Anna+J%3BCooper%2C+Willie+M%3BBuzatu%2C+Dan+A&rft.aulast=Xue&rft.aufirst=Yong&rft.date=2017-02-01&rft.volume=71&rft.issue=&rft.spage=2.25.1&rft.isbn=&rft.btitle=&rft.title=Current+protocols+in+toxicology&rft.issn=1934-9262&rft_id=info:doi/10.1002%2Fcptx.14 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-02-01 N1 - Date revised - 2017-02-03 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1002/cptx.14 ER - TY - JOUR T1 - Whole genome sequencing of mouse lymphoma L5178Y-3.7.2C (TK+/-) reveals millions of mutations and genetic markers. AN - 1863217172; 28137362 AB - The mouse lymphoma L5178Y-3.7.2C (TK+/-) cell line is extensively used in genetic toxicology to conduct the mouse lymphoma assay (MLA). The MLA is used to establish the mutagenic and clastogenic effects of chemicals and pharmaceuticals, and is one of the few genetic tests widely accepted by regulatory agencies throughout the world. Despite the extensive use and regulatory impact of L5178Y-3.7.2C (TK+/-) cells, little is known about their genetic composition or how it affects the outcome of the MLA. To determine the genetic background of this cell line, we sequenced and analyzed its entire genome. Our results confirm the existence of previously described mutations in the Tk1 and Trp53 genes and catalog millions of other mutations, many of which impair the function of genes with key roles in cell physiology and genetic toxicology. Published by Elsevier B.V. JF - Mutation research AU - McKinzie, Page B AU - Revollo, Javier R AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Page.McKinzie@fda.hhs.gov. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Javier.Revollo@fda.hhs.gov. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 1 EP - 6 VL - 814 KW - Genetics KW - Next generation sequencing KW - SNPs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1863217172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Whole+genome+sequencing+of+mouse+lymphoma+L5178Y-3.7.2C+%28TK%2B%2F-%29+reveals+millions+of+mutations+and+genetic+markers.&rft.au=McKinzie%2C+Page+B%3BRevollo%2C+Javier+R&rft.aulast=McKinzie&rft.aufirst=Page&rft.date=2017-02-01&rft.volume=30&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgeu082 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-31 N1 - Date revised - 2017-02-02 N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1016/j.mrgentox.2016.12.001 ER - TY - JOUR T1 - The Epicenter of Effectiveness and Efficiency in Health Care Delivery: The Evolving U.S. Health Workforce AN - 1862137659 AB - In the decade between 2014 and 2024, the health care and social assistance sector is projected to add more jobs to the U.S. economy than any other industry (BLS, 2015). According to the Bureau of Labor Statistics, 19 of the 30 fastest growing occupations in the United States are in health care (BLS, 2016). The drivers of this demand in health care employment include an increased need for care by a rapidly aging population, expansion of insurance coverage under the Affordable Care Act (ACA), and subsector innovations, such as those in Health Information Technology and medical science. In addition to these factors, the push toward improved access to care and improved quality of care has put the health care workforce at the center of the system transformation “storm.” This environment has created a demand for an innovative and flexible health care workforce. However, there are very real concerns that the United States does not and will not have the workforce it needs to meet this demand without significant change. This sentiment stems from several current trends. First, there is the question of whether there will be enough providers in certain occupations and professions. Workforce projections for health care occupations vary in terms of predicted shortages and surpluses (HRSA, 2016). Second, there continues to be uneven geographic distribution for some occupations, including dentists (HRSA, 2015), primary care physicians (Petterson et al. 2013; AHRQ, 2014), and nurses (HRSA, 2014). Finally, how and what providers learn when they are trained for practice, with an eye toward improved delivery and quality of care, is still evolving. For example, there has been a movement toward teaching interprofessional, team-based care (Bridgeset al. 2011). JF - Health Services Research AU - Washko, Michelle M AU - Fennell, Mary L AD - National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD ; Department of Sociology, Department of Health Services Policy and Practice, Brown University, Providence, RI ; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 353 EP - 359 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - S1 SN - 0017-9124 KW - Medical Sciences KW - Labour force KW - Health care KW - Service delivery KW - Care delivery KW - Occupational health and safety KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862137659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=The+Epicenter+of+Effectiveness+and+Efficiency+in+Health+Care+Delivery%3A+The+Evolving+U.S.+Health+Workforce&rft.au=Washko%2C+Michelle+M%3BFennell%2C+Mary+L&rft.aulast=Washko&rft.aufirst=Michelle&rft.date=2017-02-01&rft.volume=52&rft.issue=S1&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12662 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-27 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1111/1475-6773.12662 ER - TY - JOUR T1 - Perspectives: Using Results from HRSA's Health Workforce Simulation Model to Examine the Geography of Primary Care AN - 1862137605 AB - Objective Inform health planning and policy discussions by describing Health Resources and Services Administration's (HRSA's) Health Workforce Simulation Model (HWSM) and examining the HWSM's 2025 supply and demand projections for primary care physicians, nurse practitioners (NPs), and physician assistants (PAs). Data Sources HRSA's recently published projections for primary care providers derive from an integrated microsimulation model that estimates health workforce supply and demand at national, regional, and state levels. Principal Findings Thirty-seven states are projected to have shortages of primary care physicians in 2025, and nine states are projected to have shortages of both primary care physicians and PAs. While no state is projected to have a 2025 shortage of primary care NPs, many states are expected to have only a small surplus. Conclusions Primary care physician shortages are projected for all parts of the United States, while primary care PA shortages are generally confined to Midwestern and Southern states. No state is projected to have shortages of all three provider types. Projected shortages must be considered in the context of baseline assumptions regarding current supply, demand, provider-service ratios, and other factors. Still, these findings suggest geographies with possible primary care workforce shortages in 2025 and offer opportunities for targeting efforts to enhance workforce flexibility. JF - Health Services Research AU - Streeter, Robin A AU - Zangaro, George A AU - Chattopadhyay, Arpita AD - National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD ; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 481 EP - 507 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - S1 SN - 0017-9124 KW - Medical Sciences KW - Doctors' assistants KW - Supply and demand KW - Labour force KW - Flexibility KW - Doctors KW - Simulation KW - Projections KW - Shortages KW - Geography KW - Health status KW - Primary health care KW - Nurse practitioners KW - Health professionals KW - Occupational health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862137605?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Perspectives%3A+Using+Results+from+HRSA%27s+Health+Workforce+Simulation+Model+to+Examine+the+Geography+of+Primary+Care&rft.au=Streeter%2C+Robin+A%3BZangaro%2C+George+A%3BChattopadhyay%2C+Arpita&rft.aulast=Streeter&rft.aufirst=Robin&rft.date=2017-02-01&rft.volume=52&rft.issue=S1&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12663 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-27 DO - http://dx.doi.org/10.1111/1475-6773.12663 ER - TY - JOUR T1 - Veterans' Location in Health Professional Shortage Areas: Implications for Access to Care and Workforce Supply AN - 1862136670 AB - Objective To describe the distribution of Veterans in areas of the United States where there are potentially inadequate supplies of health professionals, and to explore opportunities suggested by this distribution for fostering health workforce flexibility. Data Sources County-level data from the 2015-2016 Health Resources and Services Administration's (HRSA's) Area Health Resources Files (AHRF) were used to estimate Veteran populations in HRSA-designated health professional shortage areas (HPSAs). This information was then linked to 2015 VA health facility information from the Department of Veterans Affairs. Study Design Potential Veteran populations living in Shortage Area Counties with no VHA facilities were estimated, and the composition of these populations was explored by Census division and state. Principal Findings Nationwide, approximately 24 percent of all Veterans and 23 percent of Veterans enrolled in VHA health care live in Shortage Area Counties. These estimates mask considerable variation across states. Conclusions An examination of Veterans residing in Shortage Area Counties suggests extensive maldistribution of health services across the United States and the continued need to find ways to improve health care access for all Veterans. Effective avenues for doing so may include increasing health workforce flexibility through expansion of nurse practitioner scopes of practice. JF - Health Services Research AU - Doyle, Jamie Mihoko AU - Streeter, Robin A AD - Office of Extramural Research, Office of the Director, National Institutes of Health, Bethesda, MD; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD ; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD ; Office of Extramural Research, Office of the Director, National Institutes of Health, Bethesda, MD; National Center for Health Workforce Analysis, Health Resources and Services Administration, Rockville, MD Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 459 EP - 480 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - S1 SN - 0017-9124 KW - Medical Sciences KW - Veterans KW - Labour force KW - Composition KW - Service provision KW - Flexibility KW - Census KW - Health services KW - Occupational health and safety KW - Health professionals KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862136670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Veterans%27+Location+in+Health+Professional+Shortage+Areas%3A+Implications+for+Access+to+Care+and+Workforce+Supply&rft.au=Doyle%2C+Jamie+Mihoko%3BStreeter%2C+Robin+A&rft.aulast=Doyle&rft.aufirst=Jamie&rft.date=2017-02-01&rft.volume=52&rft.issue=S1&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12633 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-27 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1111/1475-6773.12633 ER - TY - JOUR T1 - Clarifying the Predictive Value of Family-Centered Care and Shared Decision Making for Pediatric Healthcare Outcomes Using the Medical Expenditure Panel Survey AN - 1861335445 AB - Objectives To estimate (1) family-centered care (FCC) and shared decision-making (SDM) prevalence, and (2) associations of FCC and SDM (FCC/SDM) with health care outcomes among U.S. children. Data Source The Medical Expenditure Panel Survey Household Component (MEPS-HC), a nationally representative survey of the noninstitutionalized, civilian population. Study Design Secondary analyses of prospectively collected data on 15,764 U.S. children were conducted to examine FCC/SDM prevalence in year 1 and associations of FCC/SDM in year 1 with health services utilization, medical expenditures, and unmet health care needs in year 2. Data Collection/Extraction Methods We combined four MEPS-HC longitudinal files from 2007 to 2011. Principal Findings FCC/SDM prevalence in year 1 varied from 38.6 to 93.7 percent, and it was lower for composites with more stringent scoring approaches. FCC/SDM composites with stringent scoring approaches in year 1 were associated with reduced unmet needs in year 2. FCC/SDM, across all year 1 composites, was not associated with health services utilization or medical expenditures in year 2. FCC/SDM year 1 subcomponents describing consensus building and mutual agreement were consistently associated with unmet health care needs in year 2. Conclusions FCC/SDM composites with stringent scoring approaches measuring consensus building and mutual agreement may have the greatest utility for pediatric health care quality improvement efforts. JF - Health Services Research AU - Lindly, Olivia J AU - Zuckerman, Katharine E AU - Mistry, Kamila B AD - School of Social and Behavioral Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR; Division of General Pediatrics, Oregon Health & Science University, Portland, OR ; Division of General Pediatrics, Oregon Health & Science University, Portland, OR ; Agency for Healthcare Research and Quality, Office of Extramural Research, Education, and Priority Populations, Rockville, MD ; School of Social and Behavioral Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR; Division of General Pediatrics, Oregon Health & Science University, Portland, OR Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 313 EP - 345 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - 1 SN - 0017-9124 KW - Medical Sciences KW - Quality management KW - Clinical outcomes KW - Extraction KW - Consensus building KW - Decision making KW - Family centred care KW - Health status KW - Collaborative decision making KW - Surveys KW - Helpseeking KW - Quality of care KW - Approaches KW - Unmet needs KW - Health services KW - Health costs KW - Expenditure KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861335445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Clarifying+the+Predictive+Value+of+Family-Centered+Care+and+Shared+Decision+Making+for+Pediatric+Healthcare+Outcomes+Using+the+Medical+Expenditure+Panel%26amp%3B%23xa0%3BSurvey&rft.au=Lindly%2C+Olivia+J%3BZuckerman%2C+Katharine+E%3BMistry%2C+Kamila+B&rft.aulast=Lindly&rft.aufirst=Olivia&rft.date=2017-02-01&rft.volume=52&rft.issue=1&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12488 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Federal Communications Commission--FCC N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-25 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1111/1475-6773.12488 ER - TY - JOUR T1 - Physician and Practice-Level Drivers and Disparities around Meaningful Use Progress AN - 1861335428 AB - Objective To identify physician and practice characteristics that are markers of success for meaningful use of electronic health records (EHRs). Data Sources American Medical Association survey, Centers for Medicare & Medicaid Services' (CMS) EHR Incentive, Pioneer Accountable Care Organization, and PECOS Programs, the Office of the National Coordinator for Health IT's Regional Extension Center Program, and National Committee for Quality Assurance Patient-centered Medical Home certification program. Study Design Retrospective analysis of 865,370 physicians' participation in CMS's EHR Incentive Program and progress to stage 1 Meaningful Use between 2011 and 2013. Physician specialty, age, practice size, geographic markers, delivery reform participation, and technical assistance receipt were predictive elements. Principal Findings Medicaid physicians were progressing more slowly to Meaningful Use than Medicare physicians: by 2013, 8 in 10 physicians registered with Medicare had achieved meaningful use, compared to one-third of Medicaid-registered physicians. The strongest predictors of meaningful use were technical assistance (79 percent more likely) and delivery reform participation (34 percent more likely). Conclusions Continued outreach and technical assistance that demonstrates strong interactions between meaningful use of health IT and delivery reform may facilitate further adoption of both initiatives. JF - Health Services Research AU - Heisey-Grove, Dawn AU - King, Jennifer A AD - U.S. Department of Health and Human Services, Office of the National Coordinator for Health IT, Washington, DC ; Aledade, Inc., Bethesda, MD ; U.S. Department of Health and Human Services, Office of the National Coordinator for Health IT, Washington, DC Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 244 EP - 267 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - 1 SN - 0017-9124 KW - Medical Sciences KW - Participation KW - Doctors KW - Health inequalities KW - Patient centredness KW - Certification KW - Technical assistance KW - Assistance KW - Quality assurance KW - Medicare KW - Computerized medical records KW - Outreach programmes KW - Medicaid KW - Health records KW - Health initiatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861335428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Physician+and+Practice-Level+Drivers+and+Disparities+around+Meaningful+Use+Progress&rft.au=Heisey-Grove%2C+Dawn%3BKing%2C+Jennifer+A&rft.aulast=Heisey-Grove&rft.aufirst=Dawn&rft.date=2017-02-01&rft.volume=52&rft.issue=1&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12481 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1111/1475-6773.12481 ER - TY - JOUR T1 - Understanding Racial and Ethnic Disparities in Postsurgical Complications Occurring in U.S. Hospitals AN - 1861335279 AB - Objective To examine the role of patient, hospital, and community characteristics on racial and ethnic disparities in in-hospital postsurgical complications. Data Sources Healthcare Cost and Utilization Project, 2011 State Inpatient Databases; American Hospital Association Annual Survey of Hospitals; Area Health Resources Files; Centers for Medicare & Medicaid Services Hospital Compare database. Methods Nonlinear hierarchical modeling was conducted to examine the odds of patients experiencing any in-hospital postsurgical complication, as defined by Agency for Healthcare Research and Quality Patient Safety Indicators. Principal Findings A total of 5,474,067 inpatient surgical discharges were assessed using multivariable logistic regression. Clinical risk, payer coverage, and community-level characteristics (especially income) completely attenuated the effect of race on the odds of postsurgical complications. Patients without private insurance were 30 to 50 percent more likely to have a complication; patients from low-income communities were nearly 12 percent more likely to experience a complication. Private, not-for-profit hospitals in small metropolitan or micropolitan areas and higher nurse-to-patient ratios led to fewer postsurgical complications. Conclusions Race does not appear to be an important determinant of in-hospital postsurgical complications, but insurance and community characteristics have an effect. A population-based approach that includes improving the socioeconomic context may help reduce disparities in these outcomes. JF - Health Services Research AU - Witt, Whitney P AU - Coffey, Rosanna M AU - Lopez-Gonzalez, Lorena AU - Barrett, Marguerite L AU - Moore, Brian J AU - Andrews, Roxanne M AU - Washington, Raynard E AD - Maternal and Child Health Research, Truven Health Analytics, Inc., Durham, NC ; Federal Government, Truven Health Analytics, Inc., Bethesda, MD ; Life Sciences, Truven Health Analytics, Inc., Austin, TX ; ML Barrett INC, San Diego, CA ; Center for Organization and Delivery Studies, Agency for Healthcare Research and Quality, Rockville, MD ; Department of Health and Human Services, Agency for Healthcare Research and Quality, Rockville, MD ; Maternal and Child Health Research, Truven Health Analytics, Inc., Durham, NC Y1 - 2017/02// PY - 2017 DA - Feb 2017 SP - 220 EP - 243 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 52 IS - 1 SN - 0017-9124 KW - Medical Sciences KW - Safety measures KW - Databases KW - Ethnic differences KW - Health inequalities KW - Private hospitals KW - Nonprofit making organizations KW - Insurance KW - Race KW - Medicare KW - Racial inequalities KW - Health insurance KW - Nonlinear KW - Medical research KW - Coverage KW - Medicaid KW - Hospitalization KW - Low income people KW - Communities KW - Complications KW - Characteristics KW - Private sector KW - Patient care KW - Socioeconomic factors KW - Health costs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861335279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Understanding+Racial+and+Ethnic+Disparities+in+Postsurgical+Complications+Occurring+in+U.S.+Hospitals&rft.au=Witt%2C+Whitney+P%3BCoffey%2C+Rosanna+M%3BLopez-Gonzalez%2C+Lorena%3BBarrett%2C+Marguerite+L%3BMoore%2C+Brian+J%3BAndrews%2C+Roxanne+M%3BWashington%2C+Raynard+E&rft.aulast=Witt&rft.aufirst=Whitney&rft.date=2017-02-01&rft.volume=52&rft.issue=1&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12475 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1111/1475-6773.12475 ER - TY - JOUR T1 - Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Research Recommendations. AN - 1859715278; 27517672 AB - BACKGROUND The current single-chemical-as-carcinogen risk assessment paradigm might underestimate or miss the cumulative effects of exposure to chemical mixtures, as highlighted in recent work from the Halifax Project. This is particularly important for chemical exposures in the low-dose range that may be affecting crucial cancer hallmark mechanisms that serve to enable carcinogenesis. OBJECTIVE Could ongoing low-dose exposures to a mixture of commonly encountered environmental chemicals produce effects in concert that lead to carcinogenesis? A workshop held at the NIEHS in August 2015 evaluated the scientific support for the low-dose mixture hypothesis of carcinogenesis and developed a research agenda. Here we describe the science that supports this novel theory, identify knowledge gaps, recommend future methodologies, and explore preventative risk assessment and policy decision-making that incorporates cancer biology, environmental health science, translational toxicology, and clinical epidemiology. DISCUSSION AND CONCLUSIONS The theoretical merits of the low-dose carcinogenesis hypothesis are well founded with clear biological relevance, and therefore, the premise warrants further investigation. Expert recommendations include the need for better insights into the ways in which noncarcinogenic constituents might combine to uniquely affect the process of cellular transformation (in vitro) and environmental carcinogenesis (in vivo), including investigations of the role of key defense mechanisms in maintaining transformed cells in a dormant state. The scientific community will need to acknowledge limitations of animal-based models in predicting human responses; evaluate biological events leading to carcinogenesis both spatially and temporally; examine the overlap between measurable cancer hallmarks and characteristics of carcinogens; incorporate epigenetic biomarkers, in silico modelling, high-performance computing and high-resolution imaging, microbiome, metabolomics, and transcriptomics into future research efforts; and build molecular annotations of network perturbations. The restructuring of many existing regulatory frameworks will require adequate testing of relevant environmental mixtures to build a critical mass of evidence on which to base policy decisions. Citation: Miller MF, Goodson WH III, Manjili MH, Kleinstreuer N, Bisson WH, Lowe L. 2017. Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: scientific underpinnings and research recommendations. Environ Health Perspect 125:163-169; http://dx.doi.org/10.1289/EHP411. JF - Environmental health perspectives AU - Miller, Mark F AU - Goodson, William H AU - Manjili, Masoud H AU - Kleinstreuer, Nicole AU - Bisson, William H AU - Lowe, Leroy AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2017/02// PY - 2017 DA - February 2017 SP - 163 EP - 169 VL - 125 IS - 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859715278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Low-Dose+Mixture+Hypothesis+of+Carcinogenesis+Workshop%3A+Scientific+Underpinnings+and+Research+Recommendations.&rft.au=Miller%2C+Mark+F%3BGoodson%2C+William+H%3BManjili%2C+Masoud+H%3BKleinstreuer%2C+Nicole%3BBisson%2C+William+H%3BLowe%2C+Leroy&rft.aulast=Pan&rft.aufirst=Hongmiao&rft.date=2015-05-01&rft.volume=42&rft.issue=5&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.issn=13675435&rft_id=info:doi/10.1007%2Fs10295-015-1599-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-02-08 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1289/EHP411 ER - TY - JOUR T1 - Simultaneous Analysis of 3-MCPD and 1,3-DCP in Asian Style Sauces Using QuEChERS Extraction and Gas Chromatography-Triple Quadrupole Mass Spectrometry. AN - 1856866657; 28064506 AB - Acid hydrolyzed vegetable protein (aHVP) is used for flavoring a wide variety of foods and also in the production of nonfermented soy sauce. During the production of aHVP, chloropropanols including 3-monochloropropane-1,2-diol (3-MCPD) and 1,3 dichloropropane-2-ol (1,3-DCP) can be formed through the reaction of the hydrochloric acid catalyst and residual fat and the reaction of 3-MCPD with acetic acid, respectively. 3-MCPD is a carcinogen, and 1,3-DCP has been classified as a genotoxic carcinogen. The European Union (EU) has set a maximum concentration of 0.02 mg/kg of 3-MCPD in aHVP, and the Food and Drug Administration (FDA) set a guidance limit of 1 mg/kg of 3-MCPD in aHVP. 1,3-DCP is not an approved food additive, and the Joint FAO/WHO Expert Committee on Food Additives (JEFCA) has set a limit at 0.005 mg/kg, which is close to the estimated method detection limit. Currently there are few analytical methods for the simultaneous determination of 3-MCPD and 1,3-DCP without derivatization due to differences in their physical chemical properties and reactivity. A new method was developed using QuEChERS (quick, easy, cheap, effective, rugged, and safe) with direct analysis of the extract without derivatization using gas chromatography-triple quadrupole mass spectrometry (GC-QQQ). Additionally, a market sampling of 60 soy sauce samples was performed in 2015 to determine if concentrations have changed since the FDA limit was set in 2008. The sampling results were compared between the new QuEChERS method and a method using phenylboronic acid (PBA) as a derivatizing agent for 3-MCPD analysis. The concentrations of 3-MCPD detected in soy sauce samples collected in 2015 (19000 genes across organs, ages, and sexes ranged from 2.35 to >109-fold, with a median of 165-fold. The expression of 278 SEGs was found to vary ≤4-fold and these genes were significantly involved in protein catabolism (proteasome and ubiquitination), RNA transport, protein processing, and the spliceosome. Such stability of expression was further validated in human samples where the expression variability of the homologous human SEGs was significantly lower than that of other genes in the human genome. It was also found that the homologous human SEGs were generally less subject to non-synonymous mutation than other genes, as would be expected of stably expressed genes. We also found that knockout of SEG homologs in mouse models was more likely to cause complete preweaning lethality than non-SEG homologs, corroborating the fundamental roles played by SEGs in biological development. Such stably expressed genes and pathways across life-stages suggest that tight control of these processes is important in basic cellular functions and that perturbation by endogenous (e.g., genetics) or exogenous agents (e.g., drugs, environmental factors) may cause serious adverse effects. JF - PloS one AU - Wang, Kejian AU - Vijay, Vikrant AU - Fuscoe, James C AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America. Y1 - 2017 PY - 2017 DA - 2017 SP - 1 VL - 12 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1865555466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Tuberculosis+Control+in+South+African+Gold+Mines%3A+Mathematical+Modeling+of+a+Trial+of+Community-Wide+Isoniazid+Preventive+Therapy&rft.au=Vynnycky%2C+Emilia%3BSumner%2C+Tom%3BFielding%2C+Katherine+L%3BLewis%2C+James+J%3BCox%2C+Andrew+P%3BHayes%2C+Richard+J%3BCorbett%2C+Elizabeth+L%3BChurchyard%2C+Gavin+J%3BGrant%2C+Alison+D%3BWhite%2C+Richard+G&rft.aulast=Vynnycky&rft.aufirst=Emilia&rft.date=2015-04-15&rft.volume=181&rft.issue=8&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwu320 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-26 N1 - Date revised - 2017-02-07 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1371/journal.pone.0170813 ER - TY - JOUR T1 - Reasons for Not Seeking Substance Use Disorder Treatment: Variations by Health Insurance Coverage AN - 1865315478 AB - A large number of adults with substance use disorder (SUD) do not receive treatment for their condition. Using data from the 2008-2013 National Survey of Drug Use and Health (NSDUH), this study analyzes why individuals with SUD report not receiving treatment even when they perceived a need for it. It further examines the variations in reported reasons for not receiving treatment by health insurance status and type. The results suggest that barriers such as stigma, lack of readiness to stop using substances, and not making treatment a priority are more common among the insured population, especially among those with private insurance. Financial barriers, such as not being able to afford the cost of treatment, are more prominent among the uninsured population. Efforts to improve utilization of treatment services will need to address financial as well as barriers related to stigma. JF - Journal of Behavioral Health Services & Research AU - Ali, Mir M, PhD AU - Teich, Judith L, MSW AU - Mutter, Ryan, PhD AD - Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA ; Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA Y1 - 2017/01// PY - 2017 DA - Jan 2017 SP - 63 EP - 74 CY - Gaithersburg PB - Springer Science & Business Media VL - 44 IS - 1 SN - 1094-3412 KW - Public Health And Safety KW - Treatment needs KW - Substance abuse disorders KW - Barriers KW - Treatment KW - Readiness KW - Stigmatization KW - Insurance KW - Health status KW - Health insurance KW - Coverage KW - Helpseeking KW - National surveys KW - Uninsured patients KW - Drug abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1865315478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Reasons+for+Not+Seeking+Substance+Use+Disorder+Treatment%3A+Variations+by+Health+Insurance+Coverage&rft.au=Ali%2C+Mir+M%2C+PhD%3BTeich%2C+Judith+L%2C+MSW%3BMutter%2C+Ryan%2C+PhD&rft.aulast=Ali&rft.aufirst=Mir&rft.date=2017-01-01&rft.volume=44&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-016-9538-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - The Journal of Behavioral Health Services & Research is a copyright of Springer, 2017. N1 - Last updated - 2017-02-06 DO - http://dx.doi.org/10.1007/s11414-016-9538-3 ER - TY - JOUR T1 - Assessing Sex Differences in the Risk of Cardiovascular Disease and Mortality per Increment in Systolic Blood Pressure: A Systematic Review and Meta-Analysis of Follow-Up Studies in the United States. AN - 1862285127; 28122035 AB - In the United States (US), cardiovascular (CV) disease accounts for nearly 20% of national health care expenses. Since costs are expected to increase with the aging population, informative research is necessary to address the growing burden of CV disease and sex-related differences in diagnosis, treatment, and outcomes. Hypertension is a major risk factor for CV disease and mortality. To evaluate whether there are sex-related differences in the effect of systolic blood pressure (SBP) on the risk of CV disease and mortality, we performed a systematic review and meta-analysis. We conducted a comprehensive search using PubMed and Google Scholar to identify US-based studies published prior to 31 December, 2015. We identified eight publications for CV disease risk, which provided 9 female and 8 male effect size (ES) observations. We also identified twelve publications for CV mortality, which provided 10 female and 18 male ES estimates. Our meta-analysis estimated that the pooled ES for increased risk of CV disease per 10 mmHg increment in SBP was 25% for women (95% Confidence Interval (CI): 1.18, 1.32) and 15% for men (95% CI: 1.11, 1.19). The pooled increase in CV mortality per 10 mm Hg SBP increment was similar for both women and men (Women: 1.16; 95% CI: 1.10, 1.23; Men: 1.17; 95% CI: 1.12, 1.22). After adjusting for age and baseline SBP, the results demonstrated that the risk of CV disease per 10 mm Hg SBP increment for women was 1.1-fold higher than men (P<0.01; 95% CI: 1.04, 1.17). Heterogeneity was moderate but significant. There was no significant sex difference in CV mortality. JF - PloS one AU - Wei, Yu-Chung AU - George, Nysia I AU - Chang, Ching-Wei AU - Hicks, Karen A AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America. ; Office of Drug Evaluation I, Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, United States of America. Y1 - 2017 PY - 2017 DA - 2017 SP - 1 VL - 12 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1862285127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Assessing+Sex+Differences+in+the+Risk+of+Cardiovascular+Disease+and+Mortality+per+Increment+in+Systolic+Blood+Pressure%3A+A+Systematic+Review+and+Meta-Analysis+of+Follow-Up+Studies+in+the+United+States.&rft.au=Wei%2C+Yu-Chung%3BGeorge%2C+Nysia+I%3BChang%2C+Ching-Wei%3BHicks%2C+Karen+A&rft.aulast=Wei&rft.aufirst=Yu-Chung&rft.date=2017-01-01&rft.volume=12&rft.issue=1&rft.spage=e0170218&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0170218 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2017-01-25 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1371/journal.pone.0170218 ER - TY - JOUR T1 - New Composites LnBDC@AC and CB[6]@AC: From Design toward Selective Adsorption of Methylene Blue or Methyl Orange AN - 1860295780 AB - New porous composites LnBDC@AC (AC = Activated carbon, Ln = Eu and Gd and BDC = 1,4-benzenedicaboxylate) and CB[6]@AC (CB[6] = Cucurbit[6]uril) were obtained using hydrothermal route. The LnBDC and CB[B] are located inside the pore of the carbon materials as was observed in SEM-EDS, XRPD and FT-IR analysis. Porosimetry analysis showed values typically between AC and LnBDC material, with pore size and surface area, respectively, 29,56 Å and 353.98 m2g-1 for LnBDC@AC and 35,53 Å and 353.98 m2g-1 for CB[6]@AC. Both materials showed good absorptive capacity of metil orange (MO) and methylene blue (MB) with selectivity as a function of pH. For acid pH, both materials present selectivity by MB and alkaline pH for MO, with notable performance for CB[6]@AC. Additionally, europium luminescence was used as structural probe to investigate the coordination environment of Eu3+ ions in the EuBDC@AC composite after adsorption experiment. JF - PLoS One AU - Santos, Guilherme deC AU - Barros, Amanda L AU - Oliveira, A Fde AU - Luz, Leonis Lda AU - Silva, Fausthon Fda AU - Demets, Grégoire J-F AU - Júnior, Severino Alves Y1 - 2017/01// PY - 2017 DA - Jan 2017 CY - San Francisco PB - Public Library of Science VL - 12 IS - 1 KW - Sciences: Comprehensive Works KW - Dyes KW - Adsorption KW - Spectrum analysis KW - Activated carbon KW - Aqueous solutions KW - Stainless steel KW - Ligands KW - Photovoltaic cells KW - Porous materials KW - Charcoal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1860295780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=New+Composites+LnBDC%40AC+and+CB%5B6%5D%40AC%3A+From+Design+toward+Selective+Adsorption+of+Methylene+Blue+or+Methyl+Orange&rft.au=Santos%2C+Guilherme+deC%3BBarros%2C+Amanda+L%3BOliveira%2C+A+Fde%3BLuz%2C+Leonis+Lda%3BSilva%2C+Fausthon+Fda%3BDemets%2C+Gr%C3%A9goire+J-F%3BJ%C3%BAnior%2C+Severino+Alves&rft.aulast=Santos&rft.aufirst=Guilherme&rft.date=2017-01-01&rft.volume=12&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pone.0170026 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - © 2017 Santos et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Santos GdC, Barros AL, de Oliveira CAF, da Luz LL, da Silva FF, Demets GJ-F, et al. (2017) New Composites LnBDC@AC and CB[6]@AC: From Design toward Selective Adsorption of Methylene Blue or Methyl Orange. PLoS ONE 12(1): e0170026. doi:10.1371/journal.pone.0170026 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1371/journal.pone.0170026 ER - TY - JOUR T1 - Trimmed means for symptom trials with dropouts. AN - 1859716096; 27523396 AB - Dropouts from randomized trials, often for lack of efficacy or toxicity, have usually been handled as 'missing data'. We suggest that they are instead complete observations, just not numeric ones. We propose an exact test of the hypothesis of no drug effect, taking all randomized patients into account, based on a readily interpretable statistic. The method also copes with a drug that is toxic in some patients but beneficial to others, a difficult problem for standard methods. A robust conclusion of efficacy can be drawn with no assumptions other than randomization. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Pharmaceutical statistics AU - Permutt, Thomas AU - Li, Feng AD - Division of Biometrics II, Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, U.S.A. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 20 EP - 28 VL - 16 IS - 1 KW - robust KW - missing data KW - dropout KW - trimmed mean UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859716096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+statistics&rft.atitle=Trimmed+means+for+symptom+trials+with+dropouts.&rft.au=Permutt%2C+Thomas%3BLi%2C+Feng&rft.aulast=Permutt&rft.aufirst=Thomas&rft.date=2017-01-01&rft.volume=16&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+statistics&rft.issn=1539-1612&rft_id=info:doi/10.1002%2Fpst.1768 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-15 N1 - Date revised - 2017-01-30 N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1002/pst.1768 ER - TY - JOUR T1 - Comparative analysis of INLIGHT(TM)-labeled enzymatically depolymerized heparin by reverse-phase chromatography and high-performance mass spectrometry AN - 1859500312; PQ0004000489 AB - Structural characterization of the microheterogeneity of heparin, heparan sulfate, and other glycosaminoglycans is a major analytical challenge. We present the use of a stable isotope-labeled hydrazide tag (INLIGHT(TM)) with high-resolution/accurate mass (HRAM) reverse-phase LC-MS/MS, which was recently introduced for detailed study of N-glycan heterogeneity, to characterize heparinase-digested heparin (digHep) products without the use of semi-volatile ion pairing reagents. Using both full scan LC-MS and data-dependent LC-MS/MS, we identified 116 unique digHep species, a feat possible because of INLIGHT(TM) labeling. Of these, 83 digHep products were structurally identified, including the 12 standard disaccharides as well as 34 tetra- (DP4), 26 hexa- (DP6), 21 octa- (DP8), and 2 decasaccharides (DP10). Each of the 116 digHep species co-eluted with both light and heavy INLIGHT(TM) tags (L/H sub(avg)=1.039 plus or minus 0.163); thus enhancing confidence in their identification via MS and MS/MS. This work sets the foundation for INLIGHT(TM)-based comparative analyses of different forms of heparin, heparan sulfate, and other GAGs with high quantitative precision using mainstay reverse-phase HRAM LC-MS/MS. [Figure not available: see fulltext.] JF - Analytical and Bioanalytical Chemistry AU - Mangrum, John B AU - Mehta, Akul Y AU - Alabbas, Alhumaidi B AU - Desai, Umesh R AU - Hawkridge, Adam M AD - Food and Drug Administration, College Park, MD, 20740-3835, USA, amhawkridge@vcu.edu Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 499 EP - 509 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 409 IS - 2 SN - 1618-2642, 1618-2642 KW - Biotechnology and Bioengineering Abstracts KW - Glycosaminoglycans KW - Chromatography KW - N-glycans KW - Microheterogeneity KW - Heparin KW - Heparan sulfate KW - Mass spectroscopy KW - Disaccharides KW - Light effects KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859500312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Comparative+analysis+of+INLIGHT%28TM%29-labeled+enzymatically+depolymerized+heparin+by+reverse-phase+chromatography+and+high-performance+mass+spectrometry&rft.au=Mangrum%2C+John+B%3BMehta%2C+Akul+Y%3BAlabbas%2C+Alhumaidi+B%3BDesai%2C+Umesh+R%3BHawkridge%2C+Adam+M&rft.aulast=Mangrum&rft.aufirst=John&rft.date=2017-01-01&rft.volume=409&rft.issue=2&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-016-0055-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 53 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Glycosaminoglycans; Chromatography; N-glycans; Microheterogeneity; Heparan sulfate; Heparin; Mass spectroscopy; Light effects; Disaccharides DO - http://dx.doi.org/10.1007/s00216-016-0055-2 ER - TY - JOUR T1 - Bacteria in a water-damaged building: associations of actinomycetes and non-tuberculous mycobacteria with respiratory health in occupants AN - 1859485901; PQ0003987188 AB - We examined microbial correlates of health outcomes in building occupants with a sarcoidosis cluster and excess asthma. We offered employees a questionnaire and pulmonary function testing and collected floor dust and liquid/sludge from drain tubing traps of heat pumps that were analyzed for various microbial agents. Forty-nine percent of participants reported any symptom reflecting possible granulomatous disease (shortness of breath on exertion, flu-like achiness, or fever and chills) weekly in the last 4 weeks. In multivariate regressions, thermophilic actinomycetes (median = 529 CFU/m super(2)) in dust were associated with FEV sub(1)/FVC [coefficient = -2.8 per interquartile range change, P = 0.02], percent predicted FEF sub(25-75%) (coefficient = -12.9, P = 0.01), and any granulomatous disease-like symptom [odds ratio (OR) = 3.1, 95% confidence interval (CI) = 1.456.73]. Mycobacteria (median = 658 CFU/m super(2)) were positively associated with asthma symptoms (OR = 1.5, 95% CI = 0.972.43). Composite score (median = 11.5) of total bacteria from heat pumps was negatively associated with asthma (0.8, 0.711.00) and positively associated with FEV sub(1)/FVC (coefficient = 0.44, P = 0.095). Endotoxin (median score = 12.0) was negatively associated with two or more granulomatous disease-like symptoms (OR = 0.8, 95% CI = 0.670.98) and asthma (0.8, 0.670.96). Fungi or (1 arrow right 3)- beta -D-glucan in dust or heat pump traps was not associated with any health outcomes. Thermophilic actinomycetes and non-tuberculous mycobacteria may have played a role in the occupants' respiratory outcomes in this water-damaged building. JF - Indoor Air AU - Park, J-H AU - Cox-Ganser, J M AU - White, S K AU - Laney, A S AU - Caulfield, S M AU - Turner, WA AU - Sumner, AD AU - Kreiss, K AD - Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 24 EP - 33 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 27 IS - 1 SN - 0905-6947, 0905-6947 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Endotoxins KW - Sludges KW - Thermophilic bacteria KW - Respiratory diseases KW - Dust KW - Fever KW - Heat exchangers KW - Drains KW - Respiratory function KW - Actinomycetes KW - Bacteria KW - Composite materials KW - Inventories KW - Fungi KW - Asthma KW - Sarcoidosis KW - Sludge KW - Buildings KW - Lung KW - Heat KW - Colony-forming cells KW - Traps KW - Indoor environments KW - A 01340:Antibiotics & Antimicrobials KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859485901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Bacteria+in+a+water-damaged+building%3A+associations+of+actinomycetes+and+non-tuberculous+mycobacteria+with+respiratory+health+in+occupants&rft.au=Park%2C+J-H%3BCox-Ganser%2C+J+M%3BWhite%2C+S+K%3BLaney%2C+A+S%3BCaulfield%2C+S+M%3BTurner%2C+WA%3BSumner%2C+AD%3BKreiss%2C+K&rft.aulast=Park&rft.aufirst=J-H&rft.date=2017-01-01&rft.volume=27&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fina.12278 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Endotoxins; Inventories; Sludges; Fungi; Thermophilic bacteria; Asthma; Sarcoidosis; Dust; Fever; Heat; Lung; Colony-forming cells; Traps; Drains; Actinomycetes; Composite materials; Bacteria; Heat exchangers; Respiratory function; Respiratory diseases; Indoor environments; Sludge; Buildings DO - http://dx.doi.org/10.1111/ina.12278 ER - TY - JOUR T1 - Nonstandard work arrangements and worker health and safety AN - 1855077409; PQ0003960549 AB - Arrangements between those who perform work and those who provide jobs come in many different forms. Standard work arrangements now exist alongside several nonstandard arrangements: agency work, contract work, and gig work. While standard work arrangements are still the most prevalent types, the rise of nonstandard work arrangements, especially temporary agency, contract, and "gig" arrangements, and the potential effects of these new arrangements on worker health and safety have captured the attention of government, business, labor, and academia. This article describes the major work arrangements in use today, profiles the nonstandard workforce, discusses several legal questions about how established principles of labor and employment law apply to nonstandard work arrangements, summarizes findings published in the past 20 years about the health and safety risks for workers in nonstandard work arrangements, and outlines current research efforts in the area of healthy work design and worker well-being. Am. J. Ind. Med. 60:1-10, 2017. JF - American Journal of Industrial Medicine AU - Howard, John AD - National Institute for Occupational Safety and Health, Washington, DC. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1 EP - 10 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 1 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Safety engineering KW - Contracts KW - Safety KW - Occupational safety KW - Employment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855077409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Persistence+of+furan-induced+epigenetic+aberrations+in+the+livers+of+F344+rats.&rft.au=de+Conti%2C+Aline%3BKobets%2C+Tetyana%3BTryndyak%2C+Volodymyr%3BBurnett%2C+Sarah+D%3BHan%2C+Tao%3BFuscoe%2C+James+C%3BBeland%2C+Frederick+A%3BDoerge%2C+Daniel+R%3BPogribny%2C+Igor+P&rft.aulast=de+Conti&rft.aufirst=Aline&rft.date=2015-04-01&rft.volume=144&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu313 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Contracts; Safety engineering; Occupational safety; Safety; Employment DO - http://dx.doi.org/10.1002/ajim.22669 ER - TY - JOUR T1 - Method for analyzing left-censored bioassay data in large cohort studies AN - 1855073749; PQ0003964141 AB - In retrospective epidemiological studies of large cohorts of workers exposed to radioactive materials, it is often necessary to analyze large numbers of bioassay data sets containing censored values, or values recorded as less than a detection limit. Censored bioassay data create problems for all bioassay analysis methods, including analytical techniques based on least-squares regression to estimate intakes. A method is presented here that uses a simple empirically-derived equation for imputing replacement values for urine uranium concentration results reported as zero or less than a detection limit, that produces minimal bias in intakes estimated using least-square regression methods with the assumption of lognormally distributed measurement errors. JF - Journal of Exposure Science and Environmental Epidemiology AU - Anderson, Jeri L AU - Apostoaei, A Iulian AD - Division of Surveillance, Hazard Evaluations and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio, USA Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1 EP - 6 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 27 IS - 1 SN - 1559-0631, 1559-0631 KW - Environment Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Bioassays KW - Mathematical models KW - Urine KW - Uranium KW - Radioactive materials KW - Occupational exposure KW - X 24390:Radioactive Materials KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855073749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Method+for+analyzing+left-censored+bioassay+data+in+large+cohort+studies&rft.au=Anderson%2C+Jeri+L%3BApostoaei%2C+A+Iulian&rft.aulast=Anderson&rft.aufirst=Jeri&rft.date=2017-01-01&rft.volume=27&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2015.36 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Mathematical models; Urine; Uranium; Radioactive materials; Bioassays; Occupational exposure DO - http://dx.doi.org/10.1038/jes.2015.36 ER - TY - JOUR T1 - Mortality in a combined cohort of uranium enrichment workers AN - 1855072458; PQ0003960548 AB - Objective To examine the patterns of cause-specific mortality and relationship between internal exposure to uranium and specific causes in a pooled cohort of 29,303 workers employed at three former uranium enrichment facilities in the United States with follow-up through 2011. Methods Cause-specific standardized mortality ratios (SMRs) for the full cohort were calculated with the U.S. population as referent. Internal comparison of the dose-response relation between selected outcomes and estimated organ doses was evaluated using regression models. Results External comparison with the U.S. population showed significantly lower SMRs in most diseases in the pooled cohort. Internal comparison showed positive associations of absorbed organ doses with multiple myeloma, and to a lesser degree with kidney cancer. Conclusion In general, these gaseous diffusion plant workers had significantly lower SMRs than the U.S. population. The internal comparison however, showed associations between internal organ doses and diseases associated with uranium exposure in previous studies. Am. J. Ind. Med. 60:96-108, 2017. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Yiin, James H AU - Anderson, Jeri L AU - Daniels, Robert D AU - Bertke, Stephen J AU - Fleming, Donald A AU - Tollerud, David J AU - Tseng, Chih-Yu AU - Chen, Pi-Hsueh AU - Waters, Kathleen M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 96 EP - 108 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 60 IS - 1 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Organs KW - Cancer KW - Workers KW - USA KW - Multiple myeloma KW - Dose-response effects KW - Uranium KW - Regression analysis KW - Standards KW - Diffusion KW - Occupational exposure KW - X 24390:Radioactive Materials KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855072458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+in+a+combined+cohort+of+uranium+enrichment+workers&rft.au=Yiin%2C+James+H%3BAnderson%2C+Jeri+L%3BDaniels%2C+Robert+D%3BBertke%2C+Stephen+J%3BFleming%2C+Donald+A%3BTollerud%2C+David+J%3BTseng%2C+Chih-Yu%3BChen%2C+Pi-Hsueh%3BWaters%2C+Kathleen+M&rft.aulast=Yiin&rft.aufirst=James&rft.date=2017-01-01&rft.volume=60&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22668 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Workers; Mortality; Multiple myeloma; Uranium; Regression analysis; Diffusion; Cancer; Occupational exposure; Dose-response effects; Standards; Organs; USA DO - http://dx.doi.org/10.1002/ajim.22668 ER - TY - JOUR T1 - Genotoxicity and gene expression analyses of liver and lung tissues of mice treated with titanium dioxide nanoparticles. AN - 1852785796; 28011748 AB - Titanium dioxide nanoparticles (TiO2 NPs) are used in paints, plastics, papers, inks, foods, toothpaste, pharmaceuticals and cosmetics. However, TiO2 NPs cause inflammation, pulmonary damage, fibrosis and lung tumours in animals and are possibly carcinogenic to humans. Although there are a large number of studies on the toxicities of TiO2 NPs, the data are inconclusive and the mechanisms underlying the toxicity are not clear. In this study, we used the Comet assay to evaluate genotoxicity and whole-genome microarray technology to analyse gene expression pattern in vivo to explore the possible mechanisms for toxicity and genotoxicity of TiO2 NPs. Mice were treated with three daily i.p. injections of 50 mg/kg 10 nm anatase TiO2 NPs and sacrificed 4 h after the last treatment. The livers and lungs were then isolated for the Comet assay and whole genome microarray analysis of gene expression. The NPs were heavily accumulated in liver and lung tissues. However, the treatment was positive for DNA strand breaks only in liver measured with the standard Comet assay, but positive for oxidative DNA adducts in both liver and lung as determined with the enzyme-modified Comet assay. The genotoxicity results suggest that DNA damage mainly resulted from oxidised nucleotides. Gene expression profiles and functional analyses revealed that exposure to TiO2 NPs triggered distinct gene expression patterns in both liver and lung tissues. The gene expression results suggest that TiO2 NPs impair DNA and cells by interrupting metabolic homeostasis in liver and by inducing oxidative stress, inflammatory responses and apoptosis in lung. These findings have broad implications when evaluating the safety of TiO2 NPs used in numerous consumer products. Published by Oxford University Press on behalf of The UK Environmental Mutagen Society 2016. JF - Mutagenesis AU - Li, Yan AU - Yan, Jian AU - Ding, Wei AU - Chen, Ying AU - Pack, Lindsay M AU - Chen, Tao AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA. ; Nanotechnology Core Facility, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079, USA, tao.chen@fda.hhs.gov. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 33 EP - 46 VL - 32 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852785796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Genotoxicity+and+gene+expression+analyses+of+liver+and+lung+tissues+of+mice+treated+with+titanium+dioxide+nanoparticles.&rft.au=Li%2C+Yan%3BYan%2C+Jian%3BDing%2C+Wei%3BChen%2C+Ying%3BPack%2C+Lindsay+M%3BChen%2C+Tao&rft.aulast=Li&rft.aufirst=Yan&rft.date=2017-01-01&rft.volume=164&rft.issue=1-2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncu370 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/gew065 ER - TY - JOUR T1 - Factors affecting the in vitro micronucleus assay for evaluation of nanomaterials. AN - 1852784343; 27567283 AB - A number of in vitro methodologies have been used to assess the genotoxicity of different nanomaterials, including titanium dioxide nanoparticles (TiO2 NPs) and silver nanoparticles (AgNPs). The in vitro micronucleus assay is one of the most commonly used test methods for genotoxicity evaluation of nanomaterials. However, due to the novel features of nanomaterials, such as high adsorption capacity and fluorescence properties, there are unexpected interactions with experimental components and detection systems. In this study, we evaluate the interference by two nanoparticles, AgNPs and TiO2 NPs, with the in vitro micronucleus assay system and possible confounding factors affecting cytotoxicity and genotoxicity assessment of the nanomaterials including cell lines with different p53 status, nanoparticle coatings and fluorescence, cytochalasin B, fetal bovine serum in cell treatment medium and different measurement methodologies for detecting micronuclei. Our results showed that micronucleus induction by AgNPs was similar when evaluated using flow cytometry or microscope, whereas the induction by TiO2 NPs was different using the two methods due to TiO2's fluorescence interference with the cytometry equipment. Cells with the mutated p53 gene were more sensitive to micronucleus induction by AgNPs than the p53 wild-type cells. The presence of serum during treatment increased the toxicity of AgNPs. The coatings of nanoparticles played an important role in the genotoxicity of AgNPs. These collective data highlight the importance of considering the unique properties of nanoparticles in assessing their genotoxicity using the in vitro micronucleus assay. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society 2016. JF - Mutagenesis AU - Li, Yan AU - Doak, Shareen H AU - Yan, Jian AU - Chen, David H AU - Zhou, Min AU - Mittelstaedt, Roberta A AU - Chen, Ying AU - Li, Chun AU - Chen, Tao AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. ; Institute of Life Science, Swansea University Medical School, Singleton Park, Swansea SA2 8PP, Wales, UK. ; Columbia College, Columbia University in the City of New York, 2960 Broadway, New York, NY 10027, USA and. ; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, 1881 East Road, Houston, TX 77054, USA. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA, tao.chen@fda.hhs.gov. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 151 EP - 159 VL - 32 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852784343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Factors+affecting+the+in+vitro+micronucleus+assay+for+evaluation+of+nanomaterials.&rft.au=Li%2C+Yan%3BDoak%2C+Shareen+H%3BYan%2C+Jian%3BChen%2C+David+H%3BZhou%2C+Min%3BMittelstaedt%2C+Roberta+A%3BChen%2C+Ying%3BLi%2C+Chun%3BChen%2C+Tao&rft.aulast=Li&rft.aufirst=Yan&rft.date=2017-01-01&rft.volume=32&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgew040 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/gew040 ER - TY - JOUR T1 - Adapting viral safety assurance strategies to continuous processing of biological products AN - 1850784785; PQ0003918271 AB - There has been a recent drive in commercial large-scale production of biotechnology products to convert current batch mode processing to continuous processing manufacturing. There have been reports of model systems capable of adapting and linking upstream and downstream technologies into a continuous manufacturing pipeline. However, in many of these proposed continuous processing model systems, viral safety has not been comprehensively addressed. Viral safety and detection is a highly important and often expensive regulatory requirement for any new biological product. To ensure success in the adaption of continuous processing to large-scale production, there is a need to consider the development of approaches that allow for seamless incorporation of viral testing and clearance/inactivation methods. In this review, we outline potential strategies to apply current viral testing and clearance/inactivation technologies to continuous processing, as well as modifications of existing unit operations to ensure the successful integration of viral clearance into the continuous processing of biological products. Biotechnol. Bioeng. 2017; 114: 21-32. Viral safety and detection is a highly important and often expensive regulatory requirement for any new biological product. In the figure, the authors present a theoretical model of viral safety and detection integration into continuous processing. In this review, they outline potential strategies to apply current/novel viral testing and clearance/inactivation technologies to continuous processing, as well as modifications of existing unit operations to ensure the successful integration of viral clearance into the continuous processing of biological products. JF - Biotechnology and Bioengineering AU - Johnson, Sarah A AU - Brown, Matthew R AU - Lute, Scott C AU - Brorson, Kurt A AD - DBRRII, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, 20993. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 21 EP - 32 PB - Wiley Subscription Services VL - 114 IS - 1 SN - 0006-3592, 0006-3592 KW - Biotechnology and Bioengineering Abstracts KW - Integration KW - Models KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850784785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Bioengineering&rft.atitle=Adapting+viral+safety+assurance+strategies+to+continuous+processing+of+biological+products&rft.au=Johnson%2C+Sarah+A%3BBrown%2C+Matthew+R%3BLute%2C+Scott+C%3BBrorson%2C+Kurt+A&rft.aulast=Johnson&rft.aufirst=Sarah&rft.date=2017-01-01&rft.volume=114&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Bioengineering&rft.issn=00063592&rft_id=info:doi/10.1002%2Fbit.26060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Integration; Models DO - http://dx.doi.org/10.1002/bit.26060 ER - TY - JOUR T1 - Autophagy function and its relationship to pathology, clinical applications, drug metabolism and toxicity AN - 1850780126; PQ0003920573 AB - Autophagy is a cellular process that facilitates nutrient turnover and removal of expended macromolecules and organelles to maintain homeostasis. The recycling of cytosolic macromolecules and damaged organelles by autophagosomes occurs through the lysosomal degradation pathway. Autophagy can also be upregulated as a prosurvival pathway in response to stress stimuli such as starvation, hypoxia or cell damage. Over the last two decades, there has been a surge in research revealing the basic molecular mechanisms of autophagy in mammalian cells. A corollary of an advanced understanding of autophagy has been a concurrent expansion of research into understanding autophagic function and dysfunction in pathology. Recent studies have revealed a pivotal role for autophagy in drug toxicity, and for utilizing autophagic components as diagnostic markers and therapeutic targets in treating disease and cancer. In this review, advances in understanding the molecular basis of mammalian autophagy, methods used to induce and evaluate autophagy, and the diverse interactions between autophagy and drug toxicity, disease progression and carcinogenesis are discussed. Autophagy has a critical role in maintaining cellular homeostasis and overall health, as loss of autophagic function is implicated in disease and cancer. Recent studies have revealed a pivotal role for autophagy in drug toxicity, and for utilizing autophagic components as diagnostic markers and therapeutic targets. In this review, we discuss advances in understanding the molecular basis of mammalian autophagy, methods to measure autophagy and the diverse interactions between autophagy and drug toxicity, disease progression and carcinogenesis. JF - Journal of Applied Toxicology AU - Petibone, Dayton M AU - Majeed, Waqar AU - Casciano, Daniel A AD - National Center for Toxicological Research, US FDA, Division of Genetic and Molecular Toxicology, Jefferson, AR, 72079, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 23 EP - 37 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 37 IS - 1 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - Molecular modelling KW - Macromolecules KW - Pathology KW - Degradation KW - Phagosomes KW - Therapeutic applications KW - Nutrients KW - Homeostasis KW - Recycling KW - Waste management KW - Mammalian cells KW - Phagocytosis KW - Drugs KW - Starvation KW - Drug metabolism KW - Stress KW - Drug development KW - Toxicity KW - Cancer KW - Hypoxia KW - Carcinogenesis KW - Organelles KW - Metabolism KW - Lysosomes KW - X 24310:Pharmaceuticals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850780126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Autophagy+function+and+its+relationship+to+pathology%2C+clinical+applications%2C+drug+metabolism+and+toxicity&rft.au=Petibone%2C+Dayton+M%3BMajeed%2C+Waqar%3BCasciano%2C+Daniel+A&rft.aulast=Petibone&rft.aufirst=Dayton&rft.date=2017-01-01&rft.volume=37&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - Starvation; Molecular modelling; Macromolecules; Drug metabolism; Phagosomes; Therapeutic applications; Stress; Drug development; Nutrients; Toxicity; Homeostasis; Recycling; Cancer; Mammalian cells; Hypoxia; Carcinogenesis; Phagocytosis; Organelles; Lysosomes; Degradation; Pathology; Drugs; Metabolism; Waste management DO - http://dx.doi.org/10.1002/jat.3393 ER - TY - JOUR T1 - Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. AN - 1847885692; 27537422 AB - In an evaluation of carbon nanotubes (CNTs) for the IARC Monograph 111, the Mechanisms Subgroup was tasked with assessing the strength of evidence on the potential carcinogenicity of CNTs in humans. The mechanistic evidence was considered to be not strong enough to alter the evaluations based on the animal data. In this paper, we provide an extended, in-depth examination of the in vivo and in vitro experimental studies according to current hypotheses on the carcinogenicity of inhaled particles and fibers. We cite additional studies of CNTs that were not available at the time of the IARC meeting in October 2014, and extend our evaluation to include carbon nanofibers (CNFs). Finally, we identify key data gaps and suggest research needs to reduce uncertainty. The focus of this review is on the cancer risk to workers exposed to airborne CNT or CNF during the production and use of these materials. The findings of this review, in general, affirm those of the original evaluation on the inadequate or limited evidence of carcinogenicity for most types of CNTs and CNFs at this time, and possible carcinogenicity of one type of CNT (MWCNT-7). The key evidence gaps to be filled by research include: investigation of possible associations between in vitro and early-stage in vivo events that may be predictive of lung cancer or mesothelioma, and systematic analysis of dose-response relationships across materials, including evaluation of the influence of physico-chemical properties and experimental factors on the observation of nonmalignant and malignant endpoints. JF - Critical reviews in toxicology AU - Kuempel, Eileen D AU - Jaurand, Marie-Claude AU - Møller, Peter AU - Morimoto, Yasuo AU - Kobayashi, Norihiro AU - Pinkerton, Kent E AU - Sargent, Linda M AU - Vermeulen, Roel C H AU - Fubini, Bice AU - Kane, Agnes B AD - a National Institute for Occupational Safety and Health , Cincinnati , OH , USA. ; b Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche , UMR 1162 , Paris , France. ; f Department of Public Health , University of Copenhagen , Copenhagen , Denmark. ; g Department of Occupational Pneumology , University of Occupational and Environmental Health , Kitakyushu City , Japan. ; h National Institute of Health Sciences , Tokyo , Japan. ; i Center for Health and the Environment, University of California , Davis , California , USA. ; j National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA. ; k Institute for Risk Assessment Sciences, Utrecht University , Utrecht , The Netherlands. ; l Department of Chemistry and "G.Scansetti" Interdepartmental Center , Università degli Studi di Torino , Torino , Italy. ; m Department of Pathology and Laboratory Medicine , Brown University , Providence , RI , USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1 EP - 58 VL - 47 IS - 1 KW - inflammation KW - lung cancer KW - Cancer mechanisms KW - genotoxicity KW - carbon nanotubes KW - cell proliferation KW - particle retention KW - pulmonary KW - mesothelioma KW - translocation KW - fibrosis KW - carbon nanofibers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1847885692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+toxicology&rft.atitle=Evaluating+the+mechanistic+evidence+and+key+data+gaps+in+assessing+the+potential+carcinogenicity+of+carbon+nanotubes+and+nanofibers+in+humans.&rft.au=Kuempel%2C+Eileen+D%3BJaurand%2C+Marie-Claude%3BM%C3%B8ller%2C+Peter%3BMorimoto%2C+Yasuo%3BKobayashi%2C+Norihiro%3BPinkerton%2C+Kent+E%3BSargent%2C+Linda+M%3BVermeulen%2C+Roel+C+H%3BFubini%2C+Bice%3BKane%2C+Agnes+B&rft.aulast=Kuempel&rft.aufirst=Eileen&rft.date=2017-01-01&rft.volume=14&rft.issue=4&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Drug+discovery&rft.issn=1474-1784&rft_id=info:doi/10.1038%2Fnrd3845-c1 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-02-13 N1 - Last updated - 2017-02-13 DO - http://dx.doi.org/10.1080/10408444.2016.1206061 ER - TY - JOUR T1 - Polybrominated diphenyl ethers (PBDES) and hexa-brominated biphenyls (Hexa-BBs) in fresh foods ingested in Taiwan. AN - 1844024729; 27884471 AB - Polybrominated diphenyl ethers (PBDEs) and hexa-brominated biphenyls (Hexa-BBs) are bioaccumulative and aggregate in the food chain. Therefore, background monitoring and risk assessment for dietary intake are necessary. In present study, a systematic sampling method was first used to collect the high fat content foodstuff such as poultry, livestock, eggs, fish, other seafood, dairy products, and the infant foods and then foodstuff with high consumption in seven categories of 600 food samples. After integrating four years of background surveys of PBDE levels (2010-2013) and one year of that of Hexa-BBs (2013), the highest estimated daily intake (EDI) of PBDEs for Taiwanese food consumption was found in 0- to 3-year-olds (mean = 9.38 ng kg-1 bw d-1, the 95% upper limit of Monte Carlo Simulation (MCS P95) was 21.52 ng kg-1 bw d-1), and the lowest in 16- to 18-year-old girls (mean = 3.35 ng kg-1 bw d-1, MCS P95 was 6.53 ng kg-1 bw d-1). Moreover, the highest of EDI of Hexa-BBs was found in 0-3 years old (mean = 0.007 ng kg-1 bw d-1, MCS P95 = 0.019 ng kg-1 bw d-1), and lowest in 17-18 years old female (mean = 0.002 ng/kg/day, MCS P95 = 0.005 ng kg-1 bw d-1). This study suggests that the large MOEs (>2.5) for the four important congeners BDE-47, -99, -153, and -209, indicate that the dietary exposures are not probably a significant health concern for Taiwanese. JF - Environmental pollution (Barking, Essex : 1987) AU - Chang, Jung-Wei AU - Hung, Chung-Feng AU - Hsu, Ya-Chen AU - Kao, Yi-Ting AU - Lee, Ching-Chang AD - Research Center for Environmental Trace Toxic Substances, National Cheng Kung University, Tainan, Taiwan. ; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, Taiwan. ; Research Center for Environmental Trace Toxic Substances, National Cheng Kung University, Tainan, Taiwan; Department of Environmental and Occupational Health, National Cheng Kung University College of Medicine, Taiwan. Electronic address: cclee@mail.ncku.edu.tw. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1180 EP - 1189 VL - 220 KW - Risk assessment KW - Food KW - Polybrominated diphenyl ethers (PBDEs) KW - Hexa-brominated biphenyls (Hexa-BBs) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844024729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.atitle=Polybrominated+diphenyl+ethers+%28PBDES%29+and+hexa-brominated+biphenyls+%28Hexa-BBs%29+in+fresh+foods+ingested+in+Taiwan.&rft.au=Chang%2C+Jung-Wei%3BHung%2C+Chung-Feng%3BHsu%2C+Ya-Chen%3BKao%2C+Yi-Ting%3BLee%2C+Ching-Chang&rft.aulast=Chang&rft.aufirst=Jung-Wei&rft.date=2017-01-01&rft.volume=220&rft.issue=&rft.spage=1180&rft.isbn=&rft.btitle=&rft.title=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.issn=1873-6424&rft_id=info:doi/10.1016%2Fj.envpol.2016.11.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-25 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1016/j.envpol.2016.11.017 ER - TY - GEN T1 - A comment on the discussion and application of statistical methods in Mandrup et al. Low-dose effects of bisphenol A on mammary gland development in rats (Andrology 4: 673-683, 2016). AN - 1842601015; 27871129 JF - Andrology AU - Felton, R P AU - Juliar, B E AU - Olson, G R AU - Delclos, K B Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 194 EP - 195 VL - 5 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842601015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Andrology&rft.atitle=A+comment+on+the+discussion+and+application+of+statistical+methods+in+Mandrup+et%C2%A0al.+Low-dose+effects+of+bisphenol+A+on+mammary+gland+development+in+rats+%28Andrology+4%3A+673-683%2C+2016%29.&rft.au=Felton%2C+R+P%3BJuliar%2C+B+E%3BOlson%2C+G+R%3BDelclos%2C+K+B&rft.aulast=Felton&rft.aufirst=R&rft.date=2017-01-01&rft.volume=5&rft.issue=1&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Andrology&rft.issn=2047-2927&rft_id=info:doi/10.1111%2Fandr.12298 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/andr.12298 ER - TY - JOUR T1 - Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study. AN - 1842600255; 27871980 AB - Furan is a volatile organic chemical that is a contaminant in many common foods. Furan is hepatocarcinogenic in mice and rats; however, the risk to humans from dietary exposure to furan cannot be estimated accurately because the lowest tested dose of furan in a 2-year bioassay in rats gave nearly a 100% incidence of cholangiocarcinoma. To provide bioassay data that can be used in preparing risk assessments, the carcinogenicity of furan was determined in male F344/N Nctr rats administered 0, 0.02, 0.044, 0.092, 0.2, 0.44, 0.92, and 2 mg furan/kg body weight (BW) by gavage 5 days/week for 2 years. Exposure to furan was associated with the development of malignant mesothelioma on membranes surrounding the epididymis and on the testicular tunics, with the increase being significant at 2 mg furan/kg BW. There was also a dose-related increase in the incidence of mononuclear cell leukemia, with the increase in incidence being significant at 0.092, 0.2, 0.92, and 2 mg furan/kg BW. Dose-related non-neoplastic liver lesions included cholangiofibrosis, mixed cell foci, basophilic foci, biliary tract hyperplasia, oval cell hyperplasia, regenerative hyperplasia, and cytoplasmic vacuolization. The most sensitive non-neoplastic lesion was cholangiofibrosis, the frequency of which increased significantly at 0.2 mg furan/kg BW. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Von Tungeln, Linda S AU - Walker, Nigel J AU - Olson, Greg R AU - Mendoza, Maria C B AU - Felton, Robert P AU - Thorn, Brett T AU - Marques, M Matilde AU - Pogribny, Igor P AU - Doerge, Daniel R AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States. ; Toxicologic Pathology Associates, Jefferson, AR 72079, United States. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. Electronic address: frederick.beland@fda.hhs.gov. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 170 EP - 181 VL - 99 KW - Rats KW - Cholangiocarcinoma KW - Cholangiofibrosis KW - Furan KW - Tumorigenicity KW - Bioassay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842600255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Low+dose+assessment+of+the+carcinogenicity+of+furan+in+male+F344%2FN+Nctr+rats+in+a+2-year+gavage+study.&rft.au=Von+Tungeln%2C+Linda+S%3BWalker%2C+Nigel+J%3BOlson%2C+Greg+R%3BMendoza%2C+Maria+C+B%3BFelton%2C+Robert+P%3BThorn%2C+Brett+T%3BMarques%2C+M+Matilde%3BPogribny%2C+Igor+P%3BDoerge%2C+Daniel+R%3BBeland%2C+Frederick+A&rft.aulast=Von+Tungeln&rft.aufirst=Linda&rft.date=2017-01-01&rft.volume=99&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.11.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.11.015 ER - TY - JOUR T1 - MicroRNA biomarkers of pancreatic injury in a canine model. AN - 1842549730; 27866884 AB - Pancreas-enriched microRNAs have been experimentally investigated in rodents as candidate serum biomarkers of pancreatic injury with several different acute pancreatic injury models. In the present study, temporal and magnitude responses of exocrine pancreas-enriched miR-216a, miR-216b, and miR-217 and endocrine-enriched miR-375 and miR-148a were measured by droplet digital PCR in serum in a caerulein model of pancreatic injury in the dog. All 5 microRNAs followed a similar time course that mirrored the responses of the conventional serum pancreatic injury biomarkers, amylase and lipase. Detection was improved through the use of assays designed against microRNA isomers (isomirs) identified by sequencing. Serum biomarker increases were concordant with histopathology defined acinar cell injury. Minimal islet cell changes were noted. The pancreas-enriched microRNAs demonstrated similar or greater sensitivity, a larger range of response, and a higher correlation to acinar cell injury compared to amylase and lipase. Our results further support the translational potential of pancreas-enriched microRNAs as sensitive biomarkers of acinar cell injury with evidence from an additional non-clinical model system. Published by Elsevier GmbH. JF - Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie AU - Rouse, Rodney AU - Rosenzweig, Barry AU - Shea, Katie AU - Knapton, Alan AU - Stewart, Sharron AU - Xu, Lin AU - Chockalingam, Ashok AU - Zadrozny, Leah AU - Thompson, Karol AD - U. S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science, HFD-910, White Oak Federal Research Center, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Electronic address: rodney.rouse@fda.hhs.gov. ; U. S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science, HFD-910, White Oak Federal Research Center, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 33 EP - 43 VL - 69 IS - 1 KW - miR-217 KW - Droplet digital PCR KW - miR-148a KW - Pancreas KW - MicroRNA KW - Isomirs KW - miR-375 KW - miR-216a KW - Biomarker KW - Pancreatitis KW - miR-216b UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842549730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+toxicologic+pathology+%3A+official+journal+of+the+Gesellschaft+fur+Toxikologische+Pathologie&rft.atitle=MicroRNA+biomarkers+of+pancreatic+injury+in+a+canine+model.&rft.au=Rouse%2C+Rodney%3BRosenzweig%2C+Barry%3BShea%2C+Katie%3BKnapton%2C+Alan%3BStewart%2C+Sharron%3BXu%2C+Lin%3BChockalingam%2C+Ashok%3BZadrozny%2C+Leah%3BThompson%2C+Karol&rft.aulast=Rouse&rft.aufirst=Rodney&rft.date=2017-01-01&rft.volume=69&rft.issue=1&rft.spage=33&rft.isbn=&rft.btitle=&rft.title=Experimental+and+toxicologic+pathology+%3A+official+journal+of+the+Gesellschaft+fur+Toxikologische+Pathologie&rft.issn=1618-1433&rft_id=info:doi/10.1016%2Fj.etp.2016.11.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.etp.2016.11.001 ER - TY - JOUR T1 - Behavioral interventions to reduce HIV risk behavior for MSM and transwomen in Southeast Asia: a systematic review AN - 1841801999 AB - This systematic review aims to gain insights from existing literature from Southeast Asian countries to improve future HIV prevention programs for men who have sex with men (MSM) and transgender women (transwomen). We conducted a systematic search in six international databases for literature published prior to 1 January 2015. We included studies describing behavioral interventions targeting MSM and/or transwomen, and conducted in at least one Southeast Asian country. Five out of 575 screened studies met the inclusion criteria and reported a significant intervention effect on at least one outcome measure, that is, condom use (with casual or commercial partner), water-based lubricant use, number of sex partners, HIV prevention knowledge, or willingness to use pre-exposure prophylaxis. Peer education/outreach was the most commonly employed type of intervention in the five included studies and was usually delivered as an element of a larger intervention package, together with condom distribution and the provision of drop-in centers. Motivational interviewing was effective, while internet-based interventions appeared to be a viable platform for intervention delivery. Nevertheless, research on behavioral interventions among MSM and transwomen in Southeast Asia is limited. Future interventions should be culturally appropriate, theoretically grounded, and rigorously evaluated. Only then can we best address the HIV epidemic among MSM and transwomen in this region. JF - AIDS Care AU - Nugroho, Adi AU - Erasmus, Vicki AU - Zomer, Tizza P AU - Wu, Qing AU - Richardus, Jan Hendrik AD - Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Public Health Study Program, Lambung Mangkurat University, Banjarbaru, Indonesia ; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands ; Department of Infectious Disease Control, Municipal Public Health Service of Rotterdam-Rijnmond, Rotterdam, The Netherlands ; Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands; Public Health Study Program, Lambung Mangkurat University, Banjarbaru, Indonesia Y1 - 2017/01// PY - 2017 DA - Jan 2017 SP - 98 EP - 104 CY - London PB - Taylor & Francis Ltd. VL - 29 IS - 1 SN - 0954-0121 KW - Medical Sciences--Psychiatry And Neurology KW - MSM KW - transgender KW - behavioral intervention KW - Southeast Asia KW - review KW - Human immunodeficiency virus--HIV KW - Behavior modification KW - Disease prevention KW - Transgender persons KW - Water KW - Inclusive education KW - Risk reduction KW - Preventive health care KW - Risk behaviour KW - Transsexuality KW - Motivational interviewing KW - Sex education KW - Databases KW - Interventions KW - HIV KW - Outreach programmes KW - Homosexuals KW - Systematic reviews KW - Preventive programmes KW - Willingness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1841801999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Behavioral+interventions+to+reduce+HIV+risk+behavior+for+MSM+and+transwomen+in+Southeast+Asia%3A+a+systematic+review&rft.au=Nugroho%2C+Adi%3BErasmus%2C+Vicki%3BZomer%2C+Tizza+P%3BWu%2C+Qing%3BRichardus%2C+Jan+Hendrik&rft.aulast=Nugroho&rft.aufirst=Adi&rft.date=2017-01-01&rft.volume=29&rft.issue=1&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2016.1200713 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © 2016 Informa UK Limited, trading as Taylor & Francis Group N1 - Last updated - 2017-01-26 N1 - SubjectsTermNotLitGenreText - Southeast Asia DO - http://dx.doi.org/10.1080/09540121.2016.1200713 ER - TY - JOUR T1 - Estimation of iodine nutrition and thyroid function status in late-gestation pregnant women in the United States: Development and application of a population-based pregnancy model. AN - 1837031165; 27818216 AB - Previously, a deterministic biologically-based dose-response (BBDR) pregnancy model was developed to evaluate moderate thyroid axis disturbances with and without thyroid-active chemical exposure in a near-term pregnant woman and fetus. In the current study, the existing BBDR model was adapted to include a wider functional range of iodine nutrition, including more severe iodine deficiency conditions, and to incorporate empirically the effects of homeostatic mechanisms. The extended model was further developed into a population-based model and was constructed using a Monte Carlo-based probabilistic framework. In order to characterize total (T4) and free (fT4) thyroxine levels for a given iodine status at the population-level, the distribution of iodine intake for late-gestation pregnant women in the U.S was reconstructed using various reverse dosimetry methods and available biomonitoring data. The range of median (mean) iodine intake values resulting from three different methods of reverse dosimetry tested was 196.5-219.9μg of iodine/day (228.2-392.9μg of iodine/day). There was minimal variation in model-predicted maternal serum T4 and ft4 thyroxine levels from use of the three reconstructed distributions of iodine intake; the range of geometric mean for T4 and fT4, was 138-151.7nmol/L and 7.9-8.7pmol/L, respectively. The average value of the ratio of the 97.5th percentile to the 2.5th percentile equaled 3.1 and agreed well with similar estimates from recent observations in third-trimester pregnant women in the U.S. In addition, the reconstructed distributions of iodine intake allowed us to estimate nutrient inadequacy for late-gestation pregnant women in the U.S. via the probability approach. The prevalence of iodine inadequacy for third-trimester pregnant women in the U.S. was estimated to be between 21% and 44%. Taken together, the current work provides an improved tool for evaluating iodine nutritional status and the corresponding thyroid function status in pregnant women in the U.S. This model enables future assessments of the relevant risk of thyroid hormone level perturbations due to exposure to thyroid-active chemicals at the population-level. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Lumen, A AU - George, N I AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Annie.Lumen@fda.hhs.gov. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Nysia.George@fda.hhs.gov. Y1 - 2017/01/01/ PY - 2017 DA - 2017 Jan 01 SP - 24 EP - 38 VL - 314 KW - Thyroid hormones KW - Biologically-base dose-response modeling KW - Biomonitoring KW - Iodine KW - Reverse dosimetry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837031165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Estimation+of+iodine+nutrition+and+thyroid+function+status+in+late-gestation+pregnant+women+in+the+United+States%3A+Development+and+application+of+a+population-based+pregnancy+model.&rft.au=Lumen%2C+A%3BGeorge%2C+N+I&rft.aulast=Lumen&rft.aufirst=A&rft.date=2017-01-01&rft.volume=314&rft.issue=&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.10.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.10.026 ER - TY - JOUR T1 - The impact of perceived intensity and frequency of police work occupational stressors on the cortisol awakening response (CAR): Findings from the BCOPS study. AN - 1837025413; 27816820 AB - Police officers encounter unpredictable, evolving, and escalating stressful demands in their work. Utilizing the Spielberger Police Stress Survey (60-item instrument for assessing specific conditions or events considered to be stressors in police work), the present study examined the association of the top five highly rated and bottom five least rated work stressors among police officers with their awakening cortisol pattern. Participants were police officers enrolled in the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) study (n=338). For each group, the total stress index (product of rating and frequency of the stressor) was calculated. Participants collected saliva by means of Salivettes at four time points: on awakening, 15, 30 and 45min after waking to examine the cortisol awakening response (CAR). Saliva samples were analyzed for free cortisol concentrations. A slope reflecting the awakening pattern of cortisol over time was estimated by fitting a linear regression model relating cortisol in log-scale to time of collection. The slope served as the outcome variable. Analysis of covariance, regression, and repeated measures models were used to determine if there was an association of the stress index with the waking cortisol pattern. There was a significant negative linear association between total stress index of the five highest stressful events and slope of the awakening cortisol regression line (trend p-value=0.0024). As the stress index increased, the pattern of the awakening cortisol regression line tended to flatten. Officers with a zero stress index showed a steep and steady increase in cortisol from baseline (which is often observed) while officers with a moderate or high stress index showed a dampened or flatter response over time. Conversely, the total stress index of the five least rated events was not significantly associated with the awakening cortisol pattern. The study suggests that police events or conditions considered highly stressful by the officers may be associated with disturbances of the typical awakening cortisol pattern. The results are consistent with previous research where chronic exposure to stressors is associated with a diminished awakening cortisol response pattern. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Psychoneuroendocrinology AU - Violanti, John M AU - Fekedulegn, Desta AU - Andrew, Michael E AU - Hartley, Tara A AU - Charles, Luenda E AU - Miller, Diane B AU - Burchfiel, Cecil M AD - Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, NY, USA. Electronic address: violanti@buffalo.edu. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: djf7@cdc.gov. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: mta6@cdc.gov. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: tow9@cdc.gov. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: ley0@cdc.gov. ; Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: dum6@cdc.gov. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. Electronic address: zar5@cdc.gov. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 124 EP - 131 VL - 75 KW - CAR KW - Police KW - Psychosocial stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837025413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychoneuroendocrinology&rft.atitle=The+impact+of+perceived+intensity+and+frequency+of+police+work+occupational+stressors+on+the+cortisol+awakening+response+%28CAR%29%3A+Findings+from+the+BCOPS+study.&rft.au=Violanti%2C+John+M%3BFekedulegn%2C+Desta%3BAndrew%2C+Michael+E%3BHartley%2C+Tara+A%3BCharles%2C+Luenda+E%3BMiller%2C+Diane+B%3BBurchfiel%2C+Cecil+M&rft.aulast=Violanti&rft.aufirst=John&rft.date=2017-01-01&rft.volume=75&rft.issue=&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=Psychoneuroendocrinology&rft.issn=1873-3360&rft_id=info:doi/10.1016%2Fj.psyneuen.2016.10.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.psyneuen.2016.10.017 ER - TY - JOUR T1 - A Brief Overview of the STP 35th Annual Symposium on the Basis and Relevance of Variation in Toxicologic Responses. AN - 1836736439; 27815490 AB - The title of the 2016 Society of Toxicologic Pathology (STP) Symposium was the "Basis and Relevance of Variation in Toxicologic Responses." Many factors may contribute to variation in toxicologic responses and can confound results, complicate interpretation of data, interfere with reproducibility, and make extrapolation to humans problematic. This brief overview summarizes speaker presentations from each session which describes important factors that may impact the interpretation of nonclinical discovery and developmental toxicity studies. In addition, summaries of the Continuing Education (CE) courses and other educational events that occurred during the Symposium are highlighted. JF - Toxicologic pathology AU - Irizarry, Armando R AU - Gropp, Kathryn E AU - Dixon, Darlene AD - 1 Eli Lilly & Company, Indianapolis, Indiana, USA. ; 2 Pfizer Inc., Groton, Connecticut, USA. ; 3 National Institute of Environmental Health Sciences and the National Toxicology Program, National Institutes of Health (NIH), U.S. Department of Health and Human Services (HHS), Research Triangle Park, North Carolina, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 52 EP - 56 VL - 45 IS - 1 KW - Toxicologic Pathology KW - clinical pathology KW - variation KW - nonclinical toxicity studies KW - toxicology KW - toxicologic responses KW - annual symposium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1836736439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=A+Brief+Overview+of+the+STP+35th+Annual+Symposium+on+the+Basis+and+Relevance+of+Variation+in+Toxicologic+Responses.&rft.au=Irizarry%2C+Armando+R%3BGropp%2C+Kathryn+E%3BDixon%2C+Darlene&rft.aulast=Irizarry&rft.aufirst=Armando&rft.date=2017-01-01&rft.volume=45&rft.issue=1&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623316675765 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623316675765 ER - TY - JOUR T1 - The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study. AN - 1836733204; 27810988 AB - Little is known about arsenic and diabetes in youth. We examined the association of arsenic with type 1 and type 2 diabetes in the SEARCH for Diabetes in Youth Case-Control (SEARCH-CC) study. Because one-carbon metabolism can influence arsenic metabolism, we also evaluated the potential interaction of folate and vitamin B12 with arsenic metabolism on the odds of diabetes. Six hundred eighty-eight participants <22 years of age (429 with type 1 diabetes, 85 with type 2 diabetes, and 174 control participants) were evaluated. Arsenic species (inorganic arsenic [iAs], monomethylated arsenic [MMA], dimethylated arsenic [DMA]), and one-carbon metabolism biomarkers (folate and vitamin B12) were measured in plasma. We used the sum of iAs, MMA, and DMA (∑As) and the individual species as biomarkers of arsenic concentrations and the relative proportions of the species over their sum (iAs%, MMA%, DMA%) as biomarkers of arsenic metabolism. Median ∑As, iAs%, MMA%, and DMA% were 83.1 ng/L, 63.4%, 10.3%, and 25.2%, respectively. ∑As was not associated with either type of diabetes. The fully adjusted odds ratios (95% CI), rescaled to compare a difference in levels corresponding to the interquartile range of iAs%, MMA%, and DMA%, were 0.68 (0.50-0.91), 1.33 (1.02-1.74), and 1.28 (1.01-1.63), respectively, for type 1 diabetes and 0.82 (0.48-1.39), 1.09 (0.65-1.82), and 1.17 (0.77-1.77), respectively, for type 2 diabetes. In interaction analysis, the odds ratio of type 1 diabetes by MMA% was 1.80 (1.25-2.58) and 0.98 (0.70-1.38) for participants with plasma folate levels above and below the median (P for interaction = 0.02), respectively. Low iAs% versus high MMA% and DMA% was associated with a higher odds of type 1 diabetes, with a potential interaction by folate levels. These data support further research on the role of arsenic metabolism in type 1 diabetes, including the interplay with one-carbon metabolism biomarkers. © 2017 by the American Diabetes Association. JF - Diabetes care AU - Grau-Pérez, Maria AU - Kuo, Chin-Chi AU - Spratlen, Miranda AU - Thayer, Kristina A AU - Mendez, Michelle A AU - Hamman, Richard F AU - Dabelea, Dana AU - Adgate, John L AU - Knowler, William C AU - Bell, Ronny A AU - Miller, Frederick W AU - Liese, Angela D AU - Zhang, Chongben AU - Douillet, Christelle AU - Drobná, Zuzana AU - Mayer-Davis, Elizabeth J AU - Styblo, Miroslav AU - Navas-Acien, Ana AD - Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD mgraupe1@jhu.edu anavasa1@jhu.edu. ; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC. ; Department of Nutrition, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC. ; Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO. ; Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Denver, Aurora, CO. ; Diabetes Epidemiology and Clinical Research Section, National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ. ; Wake Forest School of Medicine, Winston-Salem, NC. ; National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD. ; Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 46 EP - 53 VL - 40 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1836733204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=The+Association+of+Arsenic+Exposure+and+Metabolism+With+Type+1+and+Type+2+Diabetes+in+Youth%3A+The+SEARCH+Case-Control+Study.&rft.au=Grau-P%C3%A9rez%2C+Maria%3BKuo%2C+Chin-Chi%3BSpratlen%2C+Miranda%3BThayer%2C+Kristina+A%3BMendez%2C+Michelle+A%3BHamman%2C+Richard+F%3BDabelea%2C+Dana%3BAdgate%2C+John+L%3BKnowler%2C+William+C%3BBell%2C+Ronny+A%3BMiller%2C+Frederick+W%3BLiese%2C+Angela+D%3BZhang%2C+Chongben%3BDouillet%2C+Christelle%3BDrobn%C3%A1%2C+Zuzana%3BMayer-Davis%2C+Elizabeth+J%3BStyblo%2C+Miroslav%3BNavas-Acien%2C+Ana&rft.aulast=Grau-P%C3%A9rez&rft.aufirst=Maria&rft.date=2017-01-01&rft.volume=40&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=1935-5548&rft_id=info:doi/10.2337%2Fdc16-0810 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2337/dc16-0810 ER - TY - JOUR T1 - Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury. AN - 1835689316; 27634590 AB - Overdose of acetaminophen (APAP) is a major cause of acute liver failure. This study was aimed to identify pathways related to hepatotoxicity and potential biomarkers of liver injury. Rats were treated with low (100 mg/kg) and high (1250 mg/kg) doses of APAP, and liver tissues at 6 and 24 h post-treatment were analyzed using a proteomic approach of 16O/18O labeling and 2D-LC-MS/MS. Molecular pathways evolved progressively from scattered and less significant perturbations to more focused and significant alterations in a dose- and time-dependent manner upon APAP treatment. Imbalanced expression of hemeoxygenase 1 (HMOX1) and biliverdin reductase A (BLVRA) was associated with hepatotoxicity. Protein abundance changes of a total of 31 proteins were uniquely correlated to liver damage, among which a dramatic increase of HMOX1 levels in plasma was observed. Liver injury-associated significant elevation of plasma HMOX1 was further validated in mice treated with APAP. This study unveiled molecular changes associated with APAP-induced liver toxicity at the pathway levels and identified HMOX1 as a potential plasma biomarker of liver injury. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Proteomics. Clinical applications AU - Gao, Yuan AU - Cao, Zhijun AU - Yang, Xi AU - Abdelmegeed, Mohamed A AU - Sun, Jinchun AU - Chen, Si AU - Beger, Richard D AU - Davis, Kelly AU - Salminen, William F AU - Song, Byoung-Joon AU - Mendrick, Donna L AU - Yu, Li-Rong AD - Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Toxicologic Pathology Associates, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 VL - 11 IS - 1-2 KW - Heme oxygenase 1 (HMOX1) KW - Hepatotoxicity KW - Acetaminophen KW - MS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835689316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=A+single+chimpanzee-human+neutralizing+monoclonal+antibody+provides+post-exposure+protection+against+type+1+and+type+2+polioviruses&rft.au=Kouiavskaia%2C+Diana%3BChen%2C+Zhaochun%3BDragunsky%2C+Eugenia%3BMirochnitchenko%2C+Olga%3BPurcell%2C+Robert%3BChumakov%2C+Konstantin&rft.aulast=Kouiavskaia&rft.aufirst=Diana&rft.date=2015-04-01&rft.volume=65&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2015.01.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/prca.201600123 ER - TY - JOUR T1 - FutureTox III: Bridges for Translation. AN - 1835685355; 27780885 AB - Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question-what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Juberg, Daland R AU - Knudsen, Thomas B AU - Sander, Miriam AU - Beck, Nancy B AU - Faustman, Elaine M AU - Mendrick, Donna L AU - Fowle, John R AU - Hartung, Thomas AU - Tice, Raymond R AU - Lemazurier, Emmanuel AU - Becker, Richard A AU - Fitzpatrick, Suzanne Compton AU - Daston, George P AU - Harrill, Alison AU - Hines, Ronald N AU - Keller, Douglas A AU - Lipscomb, John C AU - Watson, David AU - Bahadori, Tina AU - Crofton, Kevin M AD - Dow AgroSciences, Indianapolis, Indiana; drjuberg@dow.com. ; US Environmental Protection Agency, Research Triangle Park, North Carolina. ; Page One Editorial Services, Boulder, Colorado. ; American Chemistry Council, Washington, The District of Columbia. ; University of Washington, Seattle, Washington. ; US Food and Drug Administration, Silver Spring, Maryland. ; Science to Inform, LLC, Pittsboro, North Carolina. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. ; National Toxicology Program/National Institute of Environmental Health Sciences, Durham, North Carolina. ; INERIS-Chronic Risk Division, Verneeuil-en-Halatte, France. ; US Food and Drug Administration, College Park, Maryland. ; Procter & Gamble Company, Cincinnati, Ohio. ; University of Arkansas for Medical Sciences, Little Rock, Arkansas. ; Sanofi, Bridgewater, New Jersey. ; US Environmental Protection Agency, Cincinnati, Ohio. ; Lhasa Limited, Leeds, United Kingdom. ; US Environmental Protection Agency, Washington, The District of Columbia. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 22 EP - 31 VL - 155 IS - 1 KW - predictive toxicology KW - testing alternatives. KW - in vitro and alternatives KW - regulatory/policy KW - risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835685355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=FutureTox+III%3A+Bridges+for+Translation.&rft.au=Juberg%2C+Daland+R%3BKnudsen%2C+Thomas+B%3BSander%2C+Miriam%3BBeck%2C+Nancy+B%3BFaustman%2C+Elaine+M%3BMendrick%2C+Donna+L%3BFowle%2C+John+R%3BHartung%2C+Thomas%3BTice%2C+Raymond+R%3BLemazurier%2C+Emmanuel%3BBecker%2C+Richard+A%3BFitzpatrick%2C+Suzanne+Compton%3BDaston%2C+George+P%3BHarrill%2C+Alison%3BHines%2C+Ronald+N%3BKeller%2C+Douglas+A%3BLipscomb%2C+John+C%3BWatson%2C+David%3BBahadori%2C+Tina%3BCrofton%2C+Kevin+M&rft.aulast=Juberg&rft.aufirst=Daland&rft.date=2017-01-01&rft.volume=155&rft.issue=1&rft.spage=22&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw194 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw194 ER - TY - JOUR T1 - The U.S. Department of Veterans' Affairs depleted uranium exposed cohort at 25 Years: Longitudinal surveillance results. AN - 1835683400; 27792941 AB - A small group of Gulf War I veterans wounded in depleted uranium (DU) friendly-fire incidents have been monitored for health changes in a clinical surveillance program at the Veterans Affairs Medical Center, Baltimore since 1994. During the spring of 2015, an in-patient clinical surveillance protocol was performed on 36 members of the cohort, including exposure monitoring for total and isotopic uranium concentrations in urine and a comprehensive assessment of health outcomes. On-going mobilization of U from embedded fragments is evidenced by elevated urine U concentrations. The DU isotopic signature is observed principally in participants possessing embedded fragments. Those with only an inhalation exposure have lower urine U concentration and a natural isotopic signature. At 25 years since first exposure to DU, an aging cohort of military veterans continues to show no U-related health effects in known target organs of U toxicity. As U body burden continues to accrue from in-situ mobilization from metal fragment depots, and increases with exposure duration, critical tissue-specific U concentration thresholds may be reached, thus recommending on-going surveillance of this veteran cohort. Published by Elsevier Inc. JF - Environmental research AU - McDiarmid, Melissa A AU - Gaitens, Joanna M AU - Hines, Stella AU - Condon, Marian AU - Roth, Tracy AU - Oliver, Marc AU - Gucer, Patricia AU - Brown, Lawrence AU - Centeno, Jose A AU - Dux, Moira AU - Squibb, Katherine S AD - Department of Veterans Affairs Medical Center Baltimore, Maryland, 10 N. Greene St., Baltimore, MD 21201, USA; Department of Medicine, University of Maryland School of Medicine, 655 W Baltimore S, Baltimore, MD 21201, USA. ; Department of Veterans Affairs Medical Center Baltimore, Maryland, 10 N. Greene St., Baltimore, MD 21201, USA. Electronic address: mcondon@medicine.umaryland.edu. ; Department of Veterans Affairs Medical Center Baltimore, Maryland, 10 N. Greene St., Baltimore, MD 21201, USA; Department of Pathology, University of Maryland School of Medicine, 655 W Baltimore S, Baltimore, MD 21201, USA. ; US Food and Drug Administration, Center for Devices and Radiological Health Office of Science and Engineering Laboratories, Silver Spring, MD 20993, USA. ; Department of Veterans Affairs Medical Center Baltimore, Maryland, 10 N. Greene St., Baltimore, MD 21201, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 175 EP - 184 VL - 152 KW - Health surveillance KW - DU bio-monitoring KW - Uranium toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835683400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=The+U.S.+Department+of+Veterans%27+Affairs+depleted+uranium+exposed+cohort+at+25+Years%3A+Longitudinal+surveillance+results.&rft.au=McDiarmid%2C+Melissa+A%3BGaitens%2C+Joanna+M%3BHines%2C+Stella%3BCondon%2C+Marian%3BRoth%2C+Tracy%3BOliver%2C+Marc%3BGucer%2C+Patricia%3BBrown%2C+Lawrence%3BCenteno%2C+Jose+A%3BDux%2C+Moira%3BSquibb%2C+Katherine+S&rft.aulast=McDiarmid&rft.aufirst=Melissa&rft.date=2017-01-01&rft.volume=152&rft.issue=&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2016.10.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envres.2016.10.016 ER - TY - JOUR T1 - Toxicity evaluations of nanoclays and thermally degraded byproducts through spectroscopical and microscopical approaches. AN - 1835665794; 27612663 AB - Montmorillonite is a type of nanoclay that originates from the clay fraction of the soil and is incorporated into polymers to form nanocomposites with enhanced mechanical strength, barrier, and flammability properties used for food packaging, automotive, and medical devices. However, with implementation in such consumer applications, the interaction of montmorillonite-based composites or derived byproducts with biological systems needs to be investigated. Herein we examined the potential of Cloisite Na+ (pristine) and Cloisite 30B (organically modified montmorillonite nanoclay) and their thermally degraded byproducts' to induce toxicity in model human lung epithelial cells. The experimental set-up mimicked biological exposure in manufacturing and disposal areas and employed cellular treatments with occupationally relevant doses of nanoclays previously characterized using spectroscopical and microscopical approaches. For nanoclay-cellular interactions and for cellular analyses respectively, biosensorial-based analytical platforms were used, with induced cellular changes being confirmed via live cell counts, viability assays, and cell imaging. Our analysis of byproducts' chemical and physical properties revealed both structural and functional changes. Real-time high throughput analyses of exposed cellular systems confirmed that nanoclay induced significant toxic effects, with Cloisite 30B showing time-dependent decreases in live cell count and cellular viability relative to control and pristine nanoclay, respectively. Byproducts produced less toxic effects; all treatments caused alterations in the cell morphology upon exposure. Our morphological, behavioral, and viability cellular changes show that nanoclays have the potential to produce toxic effects when used both in manufacturing or disposal environments. The reported toxicological mechanisms prove the extensibility of a biosensorial-based platform for cellular behavior analysis upon treatment with a variety of nanomaterials. Copyright © 2016 Elsevier B.V. All rights reserved. JF - Biochimica et biophysica acta AU - Wagner, Alixandra AU - Eldawud, Reem AU - White, Andrew AU - Agarwal, Sushant AU - Stueckle, Todd A AU - Sierros, Konstantinos A AU - Rojanasakul, Yon AU - Gupta, Rakesh K AU - Dinu, Cerasela Zoica AD - Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV 26506, USA. ; National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. ; Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, WV 26506, USA. ; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA. ; Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV 26506, USA. Electronic address: rakesh.gupta@mail.wvu.edu. ; Department of Chemical and Biomedical Engineering, West Virginia University, Morgantown, WV 26506, USA. Electronic address: cerasela-zoica.dinu@mail.wvu.edu. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 3406 EP - 3415 VL - 1861 IS - 1 Pt A SN - 0006-3002, 0006-3002 KW - Thermal degradation KW - Lung cell KW - Montmorillonite KW - Toxicity KW - Nanoclay KW - Byproduct UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835665794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Toxicity+evaluations+of+nanoclays+and+thermally+degraded+byproducts+through+spectroscopical+and+microscopical+approaches.&rft.au=Wagner%2C+Alixandra%3BEldawud%2C+Reem%3BWhite%2C+Andrew%3BAgarwal%2C+Sushant%3BStueckle%2C+Todd+A%3BSierros%2C+Konstantinos+A%3BRojanasakul%2C+Yon%3BGupta%2C+Rakesh+K%3BDinu%2C+Cerasela+Zoica&rft.aulast=Wagner&rft.aufirst=Alixandra&rft.date=2017-01-01&rft.volume=1861&rft.issue=1+Pt+A&rft.spage=3406&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbagen.2016.09.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbagen.2016.09.003 ER - TY - JOUR T1 - Is It Adverse, Nonadverse, Adaptive, or Artifact? AN - 1835517625; 27770107 AB - One of the principal challenges facing a toxicologic pathologist is to determine and differentiate a true adverse effect from a nonadverse or an adaptive response. Recent publications from the Society of Toxicologic Pathology (STP) and the European STP provide guidance for determining and communicating adversity in nonclinical toxicology studies. In order to provide a forum to inform and engage in a discussion on this important topic, a continuing education (CE) course was held during the 2016 STP Annual meeting in San Diego, CA. The lectures at this course provided guidance on determining and communicating adversity using case studies involving both clinical pathology and anatomic pathology. In addition, one talk also focused on data quality, study design, and interpretation of artifacts that could hinder the determination of adversity. The CE course ended with a talk on understanding adversity in preclinical studies and engaging the regulatory agencies in the decision-making process. This manuscript is designed to provide brief summaries of all the talks in this well-received CE course. JF - Toxicologic pathology AU - Pandiri, Arun R AU - Kerlin, Roy L AU - Mann, Peter C AU - Everds, Nancy E AU - Sharma, Alok K AU - Myers, L Peyton AU - Steinbach, Thomas J AD - 1 National Toxicology Program, Research Triangle Park, North Carolina, USA. ; 2 Drug Safety Research and Development, Pfizer Inc., Groton, Connecticut, USA. ; 3 Experimental Pathology Laboratories, Inc., Northwest, Seattle, Washington, USA. ; 4 Amgen Inc., South San Francisco, California, USA. ; 5 Covance Laboratories, Madison, Wisconsin, USA. ; 6 U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ; 7 Experimental Pathology Laboratories, Inc., Durham, North Carolina, USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 238 EP - 247 VL - 45 IS - 1 KW - nonadverse response KW - artifact KW - adversity KW - adaptive response UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835517625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Is+It+Adverse%2C+Nonadverse%2C+Adaptive%2C+or+Artifact%3F&rft.au=Pandiri%2C+Arun+R%3BKerlin%2C+Roy+L%3BMann%2C+Peter+C%3BEverds%2C+Nancy+E%3BSharma%2C+Alok+K%3BMyers%2C+L+Peyton%3BSteinbach%2C+Thomas+J&rft.aulast=Pandiri&rft.aufirst=Arun&rft.date=2017-01-01&rft.volume=45&rft.issue=1&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623316672352 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-22 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1177/0192623316672352 ER - TY - JOUR T1 - Hepatotoxicity associated with weight loss or sports dietary supplements, including OxyELITE Pro™ - United States, 2013. AN - 1826710075; 27367536 AB - In September 2013, the Hawaii Department of Health (HDOH) was notified of seven adults who developed acute hepatitis after taking OxyELITE Pro™, a weight loss and sports dietary supplement. CDC assisted HDOH with their investigation, then conducted case-finding outside of Hawaii with FDA and the Department of Defense (DoD). We defined cases as acute hepatitis of unknown etiology that occurred from April 1, 2013, through December 5, 2013, following exposure to a weight loss or muscle-building dietary supplement, such as OxyELITE Pro™. We conducted case-finding through multiple sources, including data from poison centers (National Poison Data System [NPDS]) and FDA MedWatch. We identified 40 case-patients in 23 states and two military bases with acute hepatitis of unknown etiology and exposure to a weight loss or muscle building dietary supplement. Of 35 case-patients who reported their race, 15 (42.9%) reported white and 9 (25.7%) reported Asian. Commonly reported symptoms included jaundice, fatigue, and dark urine. Twenty-five (62.5%) case-patients reported taking OxyELITE Pro™. Of these 25 patients, 17 of 22 (77.3%) with available data were hospitalized and 1 received a liver transplant. NPDS and FDA MedWatch each captured seven (17.5%) case-patients. Improving the ability to search surveillance systems like NPDS and FDA MedWatch for individual and grouped dietary supplements, as well as coordinating case-finding with DoD, may benefit ongoing surveillance efforts and future outbreak responses involving adverse health effects from dietary supplements. This investigation highlights opportunities and challenges in using multiple sources to identify cases of suspected supplement associated adverse events. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Drug testing and analysis AU - Chatham-Stephens, Kevin AU - Taylor, Ethel AU - Chang, Arthur AU - Peterson, Amy AU - Daniel, Johnni AU - Martin, Colleen AU - Deuster, Patricia AU - Noe, Rebecca AU - Kieszak, Stephanie AU - Schier, Josh AU - Klontz, Karl AU - Lewis, Lauren AD - EIS officer, 1600 Clifton Road NE MS C-09, Atlanta, GA. ; Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention. ; Division of Integrated Biosurveillance, Armed Forces Health Surveillance Center. ; Department of Military and Emergency Medicine, Uniformed Services University. ; Office of Analytics and Outreach, Center for Food Safety and Applied Nutrition, Food and Drug Administration. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 68 EP - 74 VL - 9 IS - 1 KW - Supplement KW - OxyELITE Pro KW - hepatitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826710075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+testing+and+analysis&rft.atitle=Hepatotoxicity+associated+with+weight+loss+or+sports+dietary+supplements%2C+including+OxyELITE+Pro%E2%84%A2+-+United+States%2C+2013.&rft.au=Chatham-Stephens%2C+Kevin%3BTaylor%2C+Ethel%3BChang%2C+Arthur%3BPeterson%2C+Amy%3BDaniel%2C+Johnni%3BMartin%2C+Colleen%3BDeuster%2C+Patricia%3BNoe%2C+Rebecca%3BKieszak%2C+Stephanie%3BSchier%2C+Josh%3BKlontz%2C+Karl%3BLewis%2C+Lauren&rft.aulast=Chatham-Stephens&rft.aufirst=Kevin&rft.date=2017-01-01&rft.volume=9&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Drug+testing+and+analysis&rft.issn=1942-7611&rft_id=info:doi/10.1002%2Fdta.2036 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/dta.2036 ER - TY - JOUR T1 - Effects of titanium dioxide nanoparticles on human keratinocytes. AN - 1826702407; 27310834 AB - Titanium dioxide (TiO2) is a ubiquitous whitening compound widely used in topical products such as sunscreens, lotions and facial creams. The damaging health effects of TiO2 inhalation has been widely studied in rats, mice and humans showing oxidative stress increase, DNA damage, cell death and inflammatory gene upregulation in lung and throat cells; however, the effects on skin cells from long-term topical use of various products remain largely unknown. In this study, we assessed the effect of specific TiO2 nanoparticles (H2TiO7) on a human keratinocyte cell line (HaCaT). We performed a comparative analysis using three TiO2 particles varying in size (Fine, Ultrafine and H2TiO7) and analyzed their effects on HaCaTs. There is a clear dose-dependent increase in superoxide production, caspase 8 and 9 activity, and apoptosis in HaCaTs after treatment with all three forms of TiO2; however, there is no consistent effect on cell viability and proliferation with either of these TiO2 particles. While there is data suggesting UV exposure can enhance the carcinogenic effects of TiO2, we did not observe any significant effect of UV-C exposure combined with TiO2 treatment on HaCaTs. Furthermore, TiO2-treated cells showed minimal effects on VEGF upregulation and Wnt signaling pathway thereby showing no potential effect on angiogenesis and malignant transformation. Overall, we report here an increase in apoptosis, which may be caspase 8/Fas-dependent, and that the H2TiO7 nanoparticles, despite their smaller particle size, had no significant enhanced effect on HaCaT cells as compared to Fine and Ultrafine forms of TiO2. JF - Drug and chemical toxicology AU - Wright, Clayton AU - Iyer, Anand Krishnan V AU - Wang, Liying AU - Wu, Nianqiang AU - Yakisich, Juan S AU - Rojanasakul, Yon AU - Azad, Neelam AD - a Department of Pharmaceutical Sciences , Hampton University , Hampton , VA , USA. ; b Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health , Morgantown , WV , USA. ; c Department of Mechanical & Aerospace Engineering , and. ; d Department of Pharmaceutical and Pharmacological Sciences , West Virginia University , Morgantown , WV , USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 90 EP - 100 VL - 40 IS - 1 KW - keratinocytes KW - Titanium dioxide KW - apoptosis KW - reactive oxygen species KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826702407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=Effects+of+titanium+dioxide+nanoparticles+on+human+keratinocytes.&rft.au=Wright%2C+Clayton%3BIyer%2C+Anand+Krishnan+V%3BWang%2C+Liying%3BWu%2C+Nianqiang%3BYakisich%2C+Juan+S%3BRojanasakul%2C+Yon%3BAzad%2C+Neelam&rft.aulast=Wright&rft.aufirst=Clayton&rft.date=2017-01-01&rft.volume=40&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=1525-6014&rft_id=info:doi/10.1080%2F01480545.2016.1185111 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-16 N1 - Date revised - 2017-02-02 N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1080/01480545.2016.1185111 ER - TY - JOUR T1 - FDA-approved drugs that interfere with laboratory tests: A systematic search of US drug labels. AN - 1826683247; 27193822 AB - Drug-related laboratory test interference or drug/laboratory test interactions (DLTI) are a major source of laboratory errors. DLTI is of concern with regard to both the clinical diagnosis and the monitoring of patients. Although there have been numerous reports about specific drugs that interfere with laboratory tests, there has not been a recent review on the topic. We herein provide a review of the known DLTI of US FDA-approved drugs based on a systematic search of DailyMed, a website containing the labels of US FDA-approved drugs. The labels for all human single-ingredient prescription drugs included in the database (1368) were searched using stemmed keywords and were manually reviewed for their relevance to DLTI. A total of 134 labels were positive, which indicated that the drug interferes with at least one clinical laboratory test. Antibacterial agents, psychotropic drugs and contrast media are the classes of drugs most likely to lead to DLTI. Urine was the clinical sample most frequently affected by DLTI. The FDA drug label is a source of information for studies of DLTI, although information is still lacking for most drugs, and additional improvements are needed for many of the existing records. Medical professionals, clinicians and laboratory staff should keep these possible interactions in mind when interpreting the results of laboratory tests, and should ensure that they obtain a complete and accurate record of all drugs being used by patients in order to anticipate potential DLTI. The development of a reporting system to address potential DLTI is warranted. JF - Critical reviews in clinical laboratory sciences AU - Yao, Hui AU - Rayburn, Elizabeth R AU - Shi, Qiang AU - Gao, Liang AU - Hu, Wenjie AU - Li, Haibo AD - a Department of Clinical Laboratory Medicine , Nantong Maternity and Child Health Hospital , Nantong , P.R. China. ; b CLIA Laboratory Director (various laboratories) , Birmingham , AL , USA , and. ; c Division of Systems Biology , National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson , AR , USA. Y1 - 2017/01// PY - 2017 DA - January 2017 SP - 1 EP - 17 VL - 54 IS - 1 KW - DailyMed KW - prescription drugs KW - Drug-related laboratory test interference KW - FDA labels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826683247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+clinical+laboratory+sciences&rft.atitle=FDA-approved+drugs+that+interfere+with+laboratory+tests%3A+A+systematic+search+of+US+drug+labels.&rft.au=Yao%2C+Hui%3BRayburn%2C+Elizabeth+R%3BShi%2C+Qiang%3BGao%2C+Liang%3BHu%2C+Wenjie%3BLi%2C+Haibo&rft.aulast=Yao&rft.aufirst=Hui&rft.date=2017-01-01&rft.volume=54&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+clinical+laboratory+sciences&rft.issn=1549-781X&rft_id=info:doi/10.1080%2F10408363.2016.1191425 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-27 N1 - Date revised - 2017-01-30 N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1080/10408363.2016.1191425 ER - TY - JOUR T1 - Activity of Selumetinib in Neurofibromatosis Type 1-Related Plexiform Neurofibromas. AN - 1854104478; 28029918 AB - Background Effective medical therapies are lacking for the treatment of neurofibromatosis type 1-related plexiform neurofibromas, which are characterized by elevated RAS-mitogen-activated protein kinase (MAPK) signaling. Methods We conducted a phase 1 trial of selumetinib (AZD6244 or ARRY-142886), an oral selective inhibitor of MAPK kinase (MEK) 1 and 2, in children who had neurofibromatosis type 1 and inoperable plexiform neurofibromas to determine the maximum tolerated dose and to evaluate plasma pharmacokinetics. Selumetinib was administered twice daily at a dose of 20 to 30 mg per square meter of body-surface area on a continuous dosing schedule (in 28-day cycles). We also tested selumetinib using a mouse model of neurofibromatosis type 1-related neurofibroma. Response to treatment (i.e., an increase or decrease from baseline in the volume of plexiform neurofibromas) was monitored by using volumetric magnetic resonance imaging analysis to measure the change in size of the plexiform neurofibroma. Results A total of 24 children (median age, 10.9 years; range, 3.0 to 18.5) with a median tumor volume of 1205 ml (range, 29 to 8744) received selumetinib. Patients were able to receive selumetinib on a long-term basis; the median number of cycles was 30 (range, 6 to 56). The maximum tolerated dose was 25 mg per square meter (approximately 60% of the recommended adult dose). The most common toxic effects associated with selumetinib included acneiform rash, gastrointestinal effects, and asymptomatic creatine kinase elevation. The results of pharmacokinetic evaluations of selumetinib among the children in this trial were similar to those published for adults. Treatment with selumetinib resulted in confirmed partial responses (tumor volume decreases from baseline of ≥20%) in 17 of the 24 children (71%) and decreases from baseline in neurofibroma volume in 12 of 18 mice (67%). Disease progression (tumor volume increase from baseline of ≥20%) has not been observed to date. Anecdotal evidence of decreases in tumor-related pain, disfigurement, and functional impairment was observed. Conclusions Our early-phase data suggested that children with neurofibromatosis type 1 and inoperable plexiform neurofibromas benefited from long-term dose-adjusted treatment with selumetinib without having excess toxic effects. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT01362803 .). JF - The New England journal of medicine AU - Dombi, Eva AU - Baldwin, Andrea AU - Marcus, Leigh J AU - Fisher, Michael J AU - Weiss, Brian AU - Kim, AeRang AU - Whitcomb, Patricia AU - Martin, Staci AU - Aschbacher-Smith, Lindsey E AU - Rizvi, Tilat A AU - Wu, Jianqiang AU - Ershler, Rachel AU - Wolters, Pamela AU - Therrien, Janet AU - Glod, John AU - Belasco, Jean B AU - Schorry, Elizabeth AU - Brofferio, Alessandra AU - Starosta, Amy J AU - Gillespie, Andrea AU - Doyle, Austin L AU - Ratner, Nancy AU - Widemann, Brigitte C AD - From the Center for Cancer Research, Pediatric Oncology Branch, Bethesda (E.D., A. Baldwin, L.J.M., P. Whitcomb, S.M., R.E., P. Wolters, J.T., J.G., A.J.S., A.G., B.C.W.) and the Cancer Therapy Evaluation Program, Shady Grove (A.L.D.), National Cancer Institute, and the National Heart, Lung, and Blood Institute (A. Brofferio), Bethesda, National Institutes of Health, and the Food and Drug Administration, Silver Spring (L.J.M., R.E.) - all in Maryland; the Division of Oncology, Children's Hospital of Philadelphia, and the Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia (M.J.F., J.B.B.); Children's National Health System, Washington, DC (A.K.); and Cincinnati Children's Hospital, Cincinnati (B.W., L.E.A.-S., T.A.R., J.W., E.S., N.R.). Y1 - 2016/12/29/ PY - 2016 DA - 2016 Dec 29 SP - 2550 EP - 2560 VL - 375 IS - 26 KW - AZD 6244 KW - 0 KW - Benzimidazoles KW - Protein Kinase Inhibitors KW - Mitogen-Activated Protein Kinase Kinases KW - EC 2.7.12.2 KW - Abridged Index Medicus KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Humans KW - Disease Progression KW - Disease Models, Animal KW - Mice KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Neurofibromatosis 1 -- drug therapy KW - Protein Kinase Inhibitors -- adverse effects KW - Neurofibroma, Plexiform -- drug therapy KW - Benzimidazoles -- adverse effects KW - Benzimidazoles -- administration & dosage KW - Protein Kinase Inhibitors -- administration & dosage KW - Protein Kinase Inhibitors -- pharmacokinetics KW - Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors KW - Benzimidazoles -- pharmacokinetics KW - Neurofibroma, Plexiform -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1854104478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Activity+of+Selumetinib+in+Neurofibromatosis+Type+1-Related+Plexiform+Neurofibromas.&rft.au=Dombi%2C+Eva%3BBaldwin%2C+Andrea%3BMarcus%2C+Leigh+J%3BFisher%2C+Michael+J%3BWeiss%2C+Brian%3BKim%2C+AeRang%3BWhitcomb%2C+Patricia%3BMartin%2C+Staci%3BAschbacher-Smith%2C+Lindsey+E%3BRizvi%2C+Tilat+A%3BWu%2C+Jianqiang%3BErshler%2C+Rachel%3BWolters%2C+Pamela%3BTherrien%2C+Janet%3BGlod%2C+John%3BBelasco%2C+Jean+B%3BSchorry%2C+Elizabeth%3BBrofferio%2C+Alessandra%3BStarosta%2C+Amy+J%3BGillespie%2C+Andrea%3BDoyle%2C+Austin+L%3BRatner%2C+Nancy%3BWidemann%2C+Brigitte+C&rft.aulast=Dombi&rft.aufirst=Eva&rft.date=2016-12-29&rft.volume=375&rft.issue=26&rft.spage=2550&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMoa1605943 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-10 N1 - Date created - 2016-12-28 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT01362803; ClinicalTrials.gov N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMoa1605943 ER - TY - JOUR T1 - Organ-specific epigenetic changes induced by the non-genotoxic liver carcinogen methapyrilene in Fischer 344 rats. AN - 1859755119; 28013212 AB - Continuous lifetime exposure to certain natural and man-made chemicals is a major cause of cancers in humans; therefore, evaluating the carcinogenic risks of chemicals remains important. Currently, substantial progress has been made in identification of genotoxic carcinogens; in contrast, predicting a carcinogenic potential of non-genotoxic compounds is a challenge due to many different modes of action that may lead to tumorigenesis. In the present study, we investigated the effects of the non-genotoxic liver carcinogen methapyrilene and the nongenotoxic non-carcinogen usnic acid at doses that do not exhibit organ cytotoxicity on epigenomic alterations in the liver and kidneys of Fischer 344 (F344) rats. We demonstrate that the repeatdose oral treatment of male F344 rats with methapyrilene for six weeks caused target organspecific epigenetic alterations in the livers. In contrast, slight or no epigenetic changes were found in the livers of F344 rats treated with hepatotoxicant, but non-carcinogen, usnic acid. Themetahpyrilene-induced epigenetic changes consisted of changes in histone lysine acetylation and methylation, with the greatest decrease being in global and gene-specific histone H3 lysine 9 (H3K9) acetylation. Importantly, the results of the present study show an association between gene-specific histone H3K9 deacetylation and a reduced expression of critical cancer-related genes, including prospero homeobox 1 (Prox1), HNF1 homebox A (Hnf1a), and peroxisome proliferator activated receptor alpha (Ppara), which provides a mechanistic link between methapyrilene-induced epigenetic aberrations and liver carcinogenesis. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Shpyleva, Svitlana AU - Dreval, Kostiantyn AU - de Conti, Aline AU - Kindrat, Iryna AU - Melnyk, Stepan AU - Yan, Jian AU - Chen, Tao AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, 72079, USA. ; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72202. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, 72079, USA. Y1 - 2016/12/24/ PY - 2016 DA - 2016 Dec 24 KW - non-genotoxic carcinogens KW - epigenetics KW - liver KW - methapyrilene UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859755119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Organ-specific+epigenetic+changes+induced+by+the+non-genotoxic+liver+carcinogen+methapyrilene+in+Fischer+344+rats.&rft.au=Shpyleva%2C+Svitlana%3BDreval%2C+Kostiantyn%3Bde+Conti%2C+Aline%3BKindrat%2C+Iryna%3BMelnyk%2C+Stepan%3BYan%2C+Jian%3BChen%2C+Tao%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Shpyleva&rft.aufirst=Svitlana&rft.date=2016-12-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw242 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw242 ER - TY - JOUR T1 - Interference of Steroidogenesis by Gold Nanorod Core/Silver Shell Nanostructures: Implications for Reproductive Toxicity of Silver Nanomaterials. AN - 1852780909; 28009471 AB - As a widely used nanomaterial in daily life, silver nanomaterials may cause great concern to female reproductive system as they are found to penetrate the blood-placental barrier and gain access to the ovary. However, it is largely unknown about how silver nanomaterials influence ovarian physiology and functions such as hormone production. This study performs in vitro toxicology study of silver nanomaterials, focusing especially on cytotoxicity and steroidogenesis and explores their underlying mechanisms. This study exposes primary rat granulosa cells to gold nanorod core/silver shell nanostructures (Au@Ag NRs), and compares outcomes with cells exposed to gold nanorods. The Au@Ag NRs generate more reactive oxygen species and reduce mitochondrial membrane potential and less production of adenosine triphosphate. Au@Ag NRs promote steroidogenesis, including progesterone and estradiol, in a time- and dose-dependent manner. Chemical reactivity and transformation of Au@Ag NRs are then studied by electron spin resonance spectroscopy and X-ray absorption near edge structure, which analyze the generation of free radical and intracellular silver species. Results suggest that both particle-specific activity and intracellular silver ion release of Au@Ag NR contribute to the toxic response of granulosa cells. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. JF - Small (Weinheim an der Bergstrasse, Germany) AU - Jiang, Xiumei AU - Wang, Liming AU - Ji, Yinglu AU - Tang, Jinglong AU - Tian, Xin AU - Cao, Mingjing AU - Li, Jingxuan AU - Bi, Shuying AU - Wu, Xiaochun AU - Chen, Chunying AU - Yin, Jun-Jie AD - CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, Beijing Key Laboratory of Ambient Particles Health Effects and Prevention Techniques, National Center for Nanoscience and Technology and Institute of High Energy Physics, Beijing, 100190, China. ; CAS Key Laboratory of Standardization and Measurement for Nanotechnology and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, China. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, 20740, USA. ; The General Hospital of the Air Force, PLA, Beijing, 100142, China. Y1 - 2016/12/23/ PY - 2016 DA - 2016 Dec 23 KW - silver nanomaterials KW - cell apoptosis KW - electron spin resonance KW - Au@Ag NRs KW - steroidogenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1852780909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Small+%28Weinheim+an+der+Bergstrasse%2C+Germany%29&rft.atitle=Interference+of+Steroidogenesis+by+Gold+Nanorod+Core%2FSilver+Shell+Nanostructures%3A+Implications+for+Reproductive+Toxicity+of+Silver+Nanomaterials.&rft.au=Jiang%2C+Xiumei%3BWang%2C+Liming%3BJi%2C+Yinglu%3BTang%2C+Jinglong%3BTian%2C+Xin%3BCao%2C+Mingjing%3BLi%2C+Jingxuan%3BBi%2C+Shuying%3BWu%2C+Xiaochun%3BChen%2C+Chunying%3BYin%2C+Jun-Jie&rft.aulast=Jiang&rft.aufirst=Xiumei&rft.date=2016-12-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Small+%28Weinheim+an+der+Bergstrasse%2C+Germany%29&rft.issn=1613-6829&rft_id=info:doi/10.1002%2Fsmll.201602855 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/smll.201602855 ER - TY - JOUR T1 - Tobacco-Specific Nitrosamines in the Tobacco and Mainstream Smoke of U.S. Commercial Cigarettes. AN - 1851693625; 28001416 AB - Tobacco-specific nitrosamines (TSNAs) are N-nitroso-derivatives of pyridine-alkaloids (e.g., nicotine) present in tobacco and cigarette smoke. Two TSNAs, N'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), are included on the Food and Drug Administration's list of harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco. The amounts of four TSNAs (NNK, NNN, N-nitrosoanabasine (NAB), and N'-nitrosoanatabine (NAT)) in the tobacco and mainstream smoke from 50 U.S. commercial cigarette brands were measured from November 15, 2011 to January 4, 2012 using a validated HPLC/MS/MS method. Smoke samples were generated using the International Organization of Standardization (ISO) and Canadian Intense (CI) machine-smoking regimens. NNN and NAT were the most abundant TSNAs in tobacco filler and smoke across all cigarette brands, whereas NNK and NAB were present in lesser amounts. The average ratios for each TSNA in mainstream smoke to filler content is 29% by the CI smoking regimen and 13% for the ISO machine-smoking regimen. The reliability of individual TSNAs to predict total TSNA amounts in the filler and smoke was examined. NNN, NAT, and NAB have a moderate to high correlation (R2 = 0.61-0.98, p < 0.0001), and all three TSNAs individually predict total TSNAs with minimal difference between measured and predicted total TSNA amounts (error < 7.4%). NNK has weaker correlation (R2 = 0.56-0.82; p < 0.0001) and is a less reliable predictor of total TSNA quantities. Tobacco weight and levels of TSNAs in filler influence TSNA levels in smoke from the CI machine-smoking regimen. In contrast, filter ventilation is a major determinant of levels of TSNAs in smoke by the ISO machine-smoking regimen. Comparative analysis demonstrates substantial variability in TSNA amounts in tobacco filler and mainstream smoke yields under ISO and CI machine-smoking regimens among U.S. commercial cigarette brands. JF - Chemical research in toxicology AU - Edwards, Selvin H AU - Rossiter, Lana M AU - Taylor, Kenneth M AU - Holman, Matthew R AU - Zhang, Liqin AU - Ding, Yan S AU - Watson, Clifford H AD - Center for Tobacco Products, Food and Drug Administration , Silver Spring, Maryland 20850, United States. ; Centers for Disease Control and Prevention, National Center for Environmental Health , Atlanta, Georgia 30341, United States. Y1 - 2016/12/21/ PY - 2016 DA - 2016 Dec 21 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851693625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Tobacco-Specific+Nitrosamines+in+the+Tobacco+and+Mainstream+Smoke+of+U.S.+Commercial+Cigarettes.&rft.au=Edwards%2C+Selvin+H%3BRossiter%2C+Lana+M%3BTaylor%2C+Kenneth+M%3BHolman%2C+Matthew+R%3BZhang%2C+Liqin%3BDing%2C+Yan+S%3BWatson%2C+Clifford+H&rft.aulast=Edwards&rft.aufirst=Selvin&rft.date=2016-12-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00268 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00268 ER - TY - JOUR T1 - Update on dietary intake of perchlorate and iodine from U.S. food and drug administration's total diet study: 2008-2012. AN - 1851295760; 28000685 AB - The U.S. Food and Drug Administration's (FDA) Total Diet Study (TDS) monitors the US food supply for pesticide residues, industrial chemicals, radionuclides, nutrients, and toxic elements. Perchlorate and iodine intakes based on concentrations in TDS samples collected between 2008 and 2012 were estimated in order to update an earlier TDS dietary assessment. Perchlorate is used as an oxidizing agent in rocket and missile fuel, is formed naturally in the atmosphere, and occurs naturally in some soils. Because of perchlorate's presence in soil, and in irrigation, processing, and source water, it is widely found in food. Iodine was included in the study because perchlorate at high doses interferes with iodide uptake in the thyroid. Iodine (the elemental form of iodide) is essential for growth and development, and metabolism. This study uses a novel statistical method based on a clustered zero-inflated lognormal distribution model to estimate mean and 95th percentile confidence interval concentrations for perchlorate and iodine in US foods. These estimates were used to estimate mean perchlorate and iodine exposures for the total US population and for 14 age/sex groups in the US population. Estimated mean perchlorate intake for the total US population was 0.13 μg/kg bw/day, with mean intakes for the 14 age/sex groups between 0.09 and 0.43 μg/kg bw/day. The estimated mean intakes of perchlorate for all age/sex groups were below EPA's reference dose (RfD) of 0.7 μg/kg bw/day. The estimated mean iodine intake for the total US population was 216.4 μg/person/day, with mean intakes ranging from 140.9 to 296.3 μg/person/day for the 14 age/sex groups, with all age/sex groups exceeding their respective estimated average requirements (EARs).Journal of Exposure Science and Environmental Epidemiology advance online publication, 21 December 2016; doi:10.1038/jes.2016.78. JF - Journal of exposure science & environmental epidemiology AU - Abt, Eileen AU - Spungen, Judith AU - Pouillot, Régis AU - Gamalo-Siebers, Margaret AU - Wirtz, Mark AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, MD, USA. Y1 - 2016/12/21/ PY - 2016 DA - 2016 Dec 21 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851295760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Update+on+dietary+intake+of+perchlorate+and+iodine+from+U.S.+food+and+drug+administration%27s+total+diet+study%3A+2008-2012.&rft.au=Abt%2C+Eileen%3BSpungen%2C+Judith%3BPouillot%2C+R%C3%A9gis%3BGamalo-Siebers%2C+Margaret%3BWirtz%2C+Mark&rft.aulast=Abt&rft.aufirst=Eileen&rft.date=2016-12-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2016.78 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jes.2016.78 ER - TY - JOUR T1 - Induction of cancer-associated fibroblast-like cells by carbon nanotubes dictates its tumorigenicity. AN - 1851299037; 27996035 AB - Tumor microenvironment has been recognized as a key determinant of tumor formation and metastasis, but how tumor microenvironment is affected by nanomaterials is essentially unknown. Here, we investigated whether carbon nanotubes (CNTs), a widely used nanomaterial with known carcinogenic potential, can affect cancer-associated fibroblasts (CAFs), which are a key component of tumor microenvironment that provides necessary support for tumor growth. We show for the first time that single-walled CNT and to a lesser extent multi-walled and its COOH-functionalized form induced CAF-like cells, which are non-tumorigenic in animals, but promote tumor growth of human lung carcinoma and CNT-transformed lung epithelial cells. The mechanism by which CNT-induced CAF-like cells promote tumor growth involved the acquisition of cancer stem cells (CSCs) in cancer population. Gene knockdown experiments showed that an expression of podoplanin on CAF-like cells is essential for their effects, indicating the functional role of CAF-like cells and podoplanin in CNT tumorigenic process. Our findings unveil a novel mechanism of CNT-induced carcinogenesis through the induction of CAF-like cells that support CSCs and drive tumor formation. Our results also suggest the potential utility of podoplanin as a mechanism-based biomarker for rapid screening of carcinogenicity of CNTs and related nanomaterials for their safer design. JF - Scientific reports AU - Luanpitpong, Sudjit AU - Wang, Liying AU - Castranova, Vincent AU - Dinu, Cerasela Zoica AU - Issaragrisil, Surapol AU - Chen, Yi Charlie AU - Rojanasakul, Yon AD - Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. ; Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. ; Pharmaceutical and Pharmacological Sciences Program, West Virginia University, WV 26506, USA. ; Department of Chemical Engineering, West Virginia University, WV 26506, USA. ; Natural Science Division, Alderson Broaddus University, Philippi, WV 26416, USA. Y1 - 2016/12/20/ PY - 2016 DA - 2016 Dec 20 SP - 39558 VL - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851299037?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Induction+of+cancer-associated+fibroblast-like+cells+by+carbon+nanotubes+dictates+its+tumorigenicity.&rft.au=Luanpitpong%2C+Sudjit%3BWang%2C+Liying%3BCastranova%2C+Vincent%3BDinu%2C+Cerasela+Zoica%3BIssaragrisil%2C+Surapol%3BChen%2C+Yi+Charlie%3BRojanasakul%2C+Yon&rft.aulast=Luanpitpong&rft.aufirst=Sudjit&rft.date=2016-12-20&rft.volume=6&rft.issue=&rft.spage=39558&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep39558 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep39558 ER - TY - JOUR T1 - New insights into the molecular mechanisms of chemical carcinogenesis: In vivo adduction of histone H2B by a reactive metabolite of the chemical carcinogen furan. AN - 1839121858; 27825936 AB - Furan is a rodent hepatocarcinogen ubiquitously found in the environment and heat-processed foods. Furan undergoes cytochrome P450 2E1-catalyzed bioactivation to cis-2-butene-1,4-dial (BDA), which has been shown to form an electrophilic conjugate (GSH-BDA) with glutathione. Both BDA and GSH-BDA yield covalent adducts with lysine residues in proteins. Dose- and time-dependent epigenetic histone alterations have been observed in furan-treated rats. While the covalent modification of histones by chemical carcinogens has long been proposed, histone-carcinogen adducts have eluded detection in vivo. In this study, we investigated if the covalent modification of histones by furan may occur in vivo prior to epigenetic histone alterations. Using a "bottom-up" methodology, involving the analysis of tryptic peptides by liquid chromatography - high resolution mass spectrometry, we obtained evidence for a cross-link between GSH-BDA and lysine 107 of histone H2B isolated from the livers of male F344 rats treated with tumorigenic doses of furan. This cross-link was detected at the shortest treatment period (90 days) in the lowest dose group (0.92mg/kg body weight/day), prior to the identification of epigenetic changes, and occurred at a lysine residue that is a target for epigenetic modifications and crucial for nucleosome stability. Our results represent the first unequivocal proof of the occurrence of carcinogen-modified histones in vivo and suggest that such modification happens at the initial stages of furan-induced carcinogenesis. This type of alteration may be general in scope, opening new insights into the mechanisms of chemical carcinogenesis/toxicity and new opportunities for the development of early compound-specific biomarkers of exposure. JF - Toxicology letters AU - Nunes, João AU - Martins, Inês L AU - Charneira, Catarina AU - Pogribny, Igor P AU - de Conti, Aline AU - Beland, Frederick A AU - Marques, M Matilde AU - Jacob, Cristina C AU - Antunes, Alexandra M M AD - Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal. Electronic address: alexandra.antunes@tecnico.ulisboa.pt. Y1 - 2016/12/15/ PY - 2016 DA - 2016 Dec 15 SP - 106 EP - 113 VL - 264 KW - Carcinogens KW - 0 KW - Furans KW - Histones KW - Peptides KW - Trypsin KW - EC 3.4.21.4 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Histone adducts KW - Furan KW - Biomarkers KW - Chemically induced cancers KW - Trypsin -- chemistry KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Carcinogenicity Tests KW - Peptides -- chemistry KW - Liver -- metabolism KW - Glutathione -- chemistry KW - Liver -- chemistry KW - Male KW - Furans -- metabolism KW - Furans -- toxicity KW - Carcinogens -- toxicity KW - Carcinogenesis -- drug effects KW - Histones -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1839121858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=New+insights+into+the+molecular+mechanisms+of+chemical+carcinogenesis%3A+In+vivo+adduction+of+histone+H2B+by+a+reactive+metabolite+of+the+chemical+carcinogen+furan.&rft.au=Nunes%2C+Jo%C3%A3o%3BMartins%2C+In%C3%AAs+L%3BCharneira%2C+Catarina%3BPogribny%2C+Igor+P%3Bde+Conti%2C+Aline%3BBeland%2C+Frederick+A%3BMarques%2C+M+Matilde%3BJacob%2C+Cristina+C%3BAntunes%2C+Alexandra+M+M&rft.aulast=Nunes&rft.aufirst=Jo%C3%A3o&rft.date=2016-12-15&rft.volume=264&rft.issue=&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2016.10.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-02 N1 - Date created - 2016-11-09 N1 - Date revised - 2017-02-07 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1016/j.toxlet.2016.10.018 ER - TY - JOUR T1 - Simple and rapid quantification of brominated vegetable oil in commercial soft drinks by LC-MS. AN - 1807080194; 27451219 AB - We report here a simple and rapid method for the quantification of brominated vegetable oil (BVO) in soft drinks based upon liquid chromatography-electrospray ionization mass spectrometry. Unlike previously reported methods, this novel method does not require hydrolysis, extraction or derivatization steps, but rather a simple "dilute and shoot" sample preparation. The quantification is conducted by mass spectrometry in selected ion recording mode and a single point standard addition procedure. The method was validated in the range of 5-25μg/mL BVO, encompassing the legal limit of 15μg/mL established by the US FDA for fruit-flavored beverages in the US market. The method was characterized by excellent intra- and inter-assay accuracy (97.3-103.4%) and very low imprecision [0.5-3.6% (RSD)]. The direct nature of the quantification, simplicity, and excellent statistical performance of this methodology constitute clear advantages in relation to previously published methods for the analysis of BVO in soft drinks. JF - Food chemistry AU - Chitranshi, Priyanka AU - Gamboa da Costa, Gonçalo AD - Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: goncalo.gamboa@fda.hhs.gov. Y1 - 2016/12/15/ PY - 2016 DA - 2016 Dec 15 SP - 567 EP - 570 VL - 213 SN - 0308-8146, 0308-8146 KW - Plant Oils KW - 0 KW - Index Medicus KW - BVO KW - Brominated vegetable oil KW - Method validation KW - LC–MS KW - Soft drinks KW - Halogenation KW - Carbonated Beverages -- analysis KW - Chromatography, Liquid -- methods KW - Beverages -- analysis KW - Plant Oils -- chemistry KW - Spectrometry, Mass, Electrospray Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807080194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+chemistry&rft.atitle=Simple+and+rapid+quantification+of+brominated+vegetable+oil+in+commercial+soft+drinks+by+LC-MS.&rft.au=Chitranshi%2C+Priyanka%3BGamboa+da+Costa%2C+Gon%C3%A7alo&rft.aulast=Chitranshi&rft.aufirst=Priyanka&rft.date=2016-12-15&rft.volume=213&rft.issue=&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Food+chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2016.06.110 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-09 N1 - Date created - 2016-07-25 N1 - Date revised - 2017-02-13 N1 - Last updated - 2017-02-13 DO - http://dx.doi.org/10.1016/j.foodchem.2016.06.110 ER - TY - JOUR T1 - Extraction and Liquid Chromatography-Tandem Mass Spectrometry Detection of 3-Monochloropropanediol Esters and Glycidyl Esters in Infant Formula. AN - 1851285226; 27960288 AB - A method was developed for the extraction of fatty acid esters of 3-chloro-1,2-propanediol (3-MCPD) and glycidol from infant formula, followed by quantitative analysis of the extracts using liquid chromatography-tandem mass spectrometry (LC-MS/MS). These process-induced chemical contaminants are found in refined vegetable oils, and studies have shown that they are potentially carcinogenic and/or genotoxic, making their presence in edible oils (and processed foods containing these oils) a potential health risk. The extraction procedure involves a liquid-liquid extraction, where powdered infant formula is dissolved in water and extracted with ethyl acetate. Following shaking, centrifugation, and drying of the organic phase, the resulting fat extract is cleaned-up using solid-phase extraction and analyzed by LC-MS/MS. Method performance was confirmed by verifying the percent recovery of each 3-MCPD and glycidyl ester in a homemade powdered infant formula reference material. Average ester recoveries in the reference material ranged from 84.9 to 109.0% (0.6-9.5% RSD). The method was also validated by fortifying three varieties of commercial infant formulas with a 3-MCPD and glycidyl ester solution. Average recoveries of the esters across all concentrations and varieties of infant formula ranged from 88.7 to 107.5% (1.0-9.5% RSD). Based on the validation results, this method is suitable for producing 3-MCPD and glycidyl ester occurrence data in all commercially available varieties of infant formula. JF - Journal of agricultural and food chemistry AU - Leigh, Jessica K AU - MacMahon, Shaun AD - Center for Food Safety and Applied Nutrition, United States Food and Drug Administration , 5001 Campus Drive, College Park, Maryland 20740, United States. Y1 - 2016/12/14/ PY - 2016 DA - 2016 Dec 14 SP - 9442 EP - 9451 VL - 64 IS - 49 KW - glycidyl esters KW - 3-MCPD KW - fat extraction KW - processing contaminants KW - glycidol KW - 3-MCPD esters KW - infant formula KW - 3-monochloropropanediol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1851285226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Extraction+and+Liquid+Chromatography-Tandem+Mass+Spectrometry+Detection+of+3-Monochloropropanediol+Esters+and+Glycidyl+Esters+in+Infant+Formula.&rft.au=Wang%2C+Hua%3BGill%2C+Vikas+S%3BCheng%2C+Chorng-Ming%3BGonzalez-Escalona%2C+Narjol%3BIrvin%2C+Kari+A%3BZheng%2C+Jie%3BBell%2C+Rebecca+L%3BJacobson%2C+Andrew+P%3BHammack%2C+Thomas+S&rft.aulast=Wang&rft.aufirst=Hua&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.06.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-12-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Battle in the New World: Helicoverpa armigera versus Helicoverpa zea (Lepidoptera: Noctuidae) AN - 1868339826; PQ0003937321 AB - The corn earworm Helicoverpa zea (Boddie) and the old world bollworm Helicoverpa armigera (Huebner) (Lepidoptera: Noctuidae) are allopatric species and occur in important agricultural crops. In maize, both species tend to infest the ear. The introduction of H. armigera in Brazil has created a new scenario, where these Helicoverpa species might cohabit and interact with one another, affecting the prevalence of each species in the agroecosystem, integrated pest management, and insect resistance management. In this study, larval occurrence and proportion of these species in maize was assessed in three regions of Brazil during three crop seasons. Interaction between the species was evaluated in interspecific and intraspecific scenarios under laboratory and field conditions. Helicoverpa zea was predominant in Rio Grande do Sul and the Planaltina, DF (central Brazil). In western Bahia, H. zea was predominant in the first collection, but approximately equal in number to H armigera in the second crop season. Both species exhibit high cannibalism/predation rates, and larval size was the primary factor for larval survival in the interaction studies. Larva of H. zea had higher survival when interacting with H. armigera, indicating that H. zea has an advantage in intraguild interactions with H. armigera in maize. Overall, the results from this study indicate that maize might play a role as a source of infestation or a sink of insecticide or Bt protein unselected H. armigera populations, depending on the H. zea:H. armigera intraguild competition and adult movement in the landscape. JF - PLoS ONE AU - Bentivenha, Jose PF AU - Paula-Moraes, Silvana V AU - Baldin, Edson LL AU - Specht, Alexandre AU - Silva, Ivana Fda AU - Hunt, Thomas E Y1 - 2016/12// PY - 2016 DA - December 2016 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 11 IS - 12 KW - Entomology Abstracts; Biotechnology and Bioengineering Abstracts KW - Helicoverpa armigera KW - Laboratories KW - Predation KW - Cannibalism KW - Larvae KW - Survival KW - Helicoverpa zea KW - Pest control KW - Crops KW - Lepidoptera KW - Interspecific KW - Infestation KW - Insecticides KW - Zea mays KW - Noctuidae KW - Competition KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - W 30930:Agricultural Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868339826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+ONE&rft.atitle=Battle+in+the+New+World%3A+Helicoverpa+armigera+versus+Helicoverpa+zea+%28Lepidoptera%3A+Noctuidae%29&rft.au=Bentivenha%2C+Jose+PF%3BPaula-Moraes%2C+Silvana+V%3BBaldin%2C+Edson+LL%3BSpecht%2C+Alexandre%3BSilva%2C+Ivana+Fda%3BHunt%2C+Thomas+E&rft.aulast=Bentivenha&rft.aufirst=Jose&rft.date=2016-12-01&rft.volume=11&rft.issue=12&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+ONE&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0167182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Interspecific; Infestation; Insecticides; Laboratories; Predation; Larvae; Cannibalism; Survival; Pest control; Competition; Crops; Helicoverpa armigera; Zea mays; Helicoverpa zea; Noctuidae; Lepidoptera DO - http://dx.doi.org/10.1371/journal.pone.0167182 ER - TY - JOUR T1 - Smoking status, usual adult occupation, and risk of recurrent urothelial bladder carcinoma: data from The Cancer Genome Atlas (TCGA) Project AN - 1868337768; PQ0004057584 AB - Tobacco smoking and occupational exposures are the leading risk factors for developing urothelial bladder carcinoma (UBC), yet little is known about the contribution of these two factors to risk of UBC recurrence. We evaluated whether smoking status and usual adult occupation are associated with time to UBC recurrence for 406 patients with muscle-invasive bladder cancer submitted to The Cancer Genome Atlas (TCGA) project. Kaplan-Meier and Cox proportional hazard methods were used to assess the association between smoking status, employment in a high-risk occupation for bladder cancer, occupational diesel exhaust exposure, and 2010 Standard Occupational Classification group and time to UBC recurrence. Data on time to recurrence were available for 358 patients over a median follow-up time of 15 months. Of these, 133 (37.2%) experienced a recurrence. Current smokers who smoked for more than 40 pack-years had an increased risk of recurrence compared to never smokers (HR 2.1, 95% CI 1.1, 4.1). Additionally, employment in a high-risk occupation was associated with a shorter time to recurrence (log-rank p = 0.005). We found an increased risk of recurrence for those employed in occupations with probable diesel exhaust exposure (HR 1.8, 95% CI 1.1, 3.0) and for those employed in production occupations (HR 2.0, 95% CI 1.1, 3.6). These findings suggest smoking status impacts risk of UBC recurrence, although several previous studies provided equivocal evidence regarding this association. In addition to the known causal relationship between occupational exposure and bladder cancer risk, our study suggests that occupation may also be related to increased risk of recurrence. JF - Cancer Causes & Control AU - Wilcox, Amber N AU - Silverman, Debra T AU - Friesen, Melissa C AU - Locke, Sarah J AU - Russ, Daniel E AU - Hyun, Noorie AU - Colt, Joanne S AU - Figueroa, Jonine D AU - Rothman, Nathaniel AU - Moore, Lee E AU - Koutros, Stella AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Rockville, MD, USA, koutross@mail.nih.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1429 EP - 1435 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 27 IS - 12 SN - 0957-5243, 0957-5243 KW - Toxicology Abstracts KW - Genomes KW - Tobacco smoking KW - Classification KW - Urinary bladder KW - Risk factors KW - Risk groups KW - Diesel KW - urothelial carcinoma KW - Occupational exposure KW - Exhausts KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868337768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Smoking+status%2C+usual+adult+occupation%2C+and+risk+of+recurrent+urothelial+bladder+carcinoma%3A+data+from+The+Cancer+Genome+Atlas+%28TCGA%29+Project&rft.au=Wilcox%2C+Amber+N%3BSilverman%2C+Debra+T%3BFriesen%2C+Melissa+C%3BLocke%2C+Sarah+J%3BRuss%2C+Daniel+E%3BHyun%2C+Noorie%3BColt%2C+Joanne+S%3BFigueroa%2C+Jonine+D%3BRothman%2C+Nathaniel%3BMoore%2C+Lee+E%3BKoutros%2C+Stella&rft.aulast=Wilcox&rft.aufirst=Amber&rft.date=2016-12-01&rft.volume=27&rft.issue=12&rft.spage=1429&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-016-0821-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Number of references - 19 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Genomes; Tobacco smoking; Classification; Urinary bladder; Risk factors; Risk groups; Diesel; urothelial carcinoma; Occupational exposure; Exhausts DO - http://dx.doi.org/10.1007/s10552-016-0821-7 ER - TY - JOUR T1 - Biodosimetry: Medicine, Science, and Systems to Support the Medical Decision-Maker Following a Large Scale Nuclear or Radiation Incident AN - 1868318008; PQ0004026991 AB - The public health and medical response to a radiological or nuclear incident requires the capability to sort, assess, treat, triage and to ultimately discharge, refer or transport people to their next step in medical care. The size of the incident and scarcity of resources at the location of each medical decision point will determine how patients are triaged and treated. This will be a rapidly evolving situation impacting medical responders at regional, national and international levels. As capabilities, diagnostics and medical countermeasures improve, a dynamic system-based approach is needed to plan for and manage the incident, and to adapt effectively in real time. In that the concepts and terms can be unfamiliar and possibly confusing, resources and a concept of operations must be considered well in advance. An essential underlying tenet is that medical evaluation and care will be managed by healthcare professionals with biodosimetry assays providing critical supporting data. JF - Radiation Protection Dosimetry AU - Coleman, C Norman AU - Koerner, John F AD - Chemical, Biological, Radiological, Nuclear and Explosive Branch, Office of Emergency Management, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC 20201, USA, john.koerner@hhs.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 38 EP - 46 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 172 IS - 1-3 SN - 0144-8420, 0144-8420 KW - Toxicology Abstracts; Environment Abstracts KW - Radiation KW - Dosimetry KW - Public health KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868318008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Biodosimetry%3A+Medicine%2C+Science%2C+and+Systems+to+Support+the+Medical+Decision-Maker+Following+a+Large+Scale+Nuclear+or+Radiation+Incident&rft.au=Coleman%2C+C+Norman%3BKoerner%2C+John+F&rft.aulast=Coleman&rft.aufirst=C&rft.date=2016-12-01&rft.volume=172&rft.issue=1-3&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncw155 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Radiation; Dosimetry; Public health DO - http://dx.doi.org/10.1093/rpd/ncw155 ER - TY - JOUR T1 - Human antibody repertoire after VSV-Ebola vaccination identifies novel targets and virus-neutralizing IgM antibodies AN - 1855083311; PQ0003943523 AB - Development of an effective vaccine against Ebola virus is of high priority. However, knowledge about potential correlates of protection and the durability of immune response after vaccination is limited. Here, we elucidate the human antibody repertoire after administration of vesicular stomatitis virus (VSV)-Ebola vaccine at 3 million, 20 million and 100 million plaque-forming units (PFU) and homologous VSV-Ebola vaccine boost in healthy adult volunteers. Whole genome-fragment phage display libraries, expressing linear and conformational epitopes of Ebola glycoprotein (GP), showed higher diversity of antibody epitopes in individuals vaccinated with 20 million PFU than in those vaccinated with 3 million or 100 million PFU. Surface plasmon resonance kinetics showed higher levels of GP-binding antibodies after a single vaccination with 20 million or 100 million PFU than with 3 million PFU, and these correlated strongly with neutralization titers. A second vaccination did not boost antibody or virus neutralization titers, which declined rapidly, and induced only minimal antibody affinity maturation. Isotype analysis revealed a predominant IgM response even after the second vaccination, which contributed substantially to virus neutralization in vitro. These findings may help identify new vaccine targets and aid development and evaluation of effective countermeasures against Ebola. JF - Nature Medicine AU - Khurana, Surender AU - Fuentes, Sandra AU - Coyle, Elizabeth M AU - Ravichandran, Supriya AU - Davey, Richard T AU - Beigel, John H AD - Division of Viral Products, Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1439 EP - 1447 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 22 IS - 12 SN - 1078-8956, 1078-8956 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - surface plasmon resonance KW - Ebolavirus KW - Rhabdoviridae KW - Kinetics KW - Phage display KW - Vaccines KW - Immune response KW - Glycoproteins KW - Vaccination KW - Immunoglobulin M KW - Epitopes KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855083311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Human+antibody+repertoire+after+VSV-Ebola+vaccination+identifies+novel+targets+and+virus-neutralizing+IgM+antibodies&rft.au=Khurana%2C+Surender%3BFuentes%2C+Sandra%3BCoyle%2C+Elizabeth+M%3BRavichandran%2C+Supriya%3BDavey%2C+Richard+T%3BBeigel%2C+John+H&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2016-12-01&rft.volume=22&rft.issue=12&rft.spage=1439&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm.4201 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - surface plasmon resonance; Kinetics; Phage display; Glycoproteins; Immune response; Vaccines; Vaccination; Epitopes; Immunoglobulin M; Rhabdoviridae; Ebolavirus DO - http://dx.doi.org/10.1038/nm.4201 ER - TY - JOUR T1 - Brain endothelial dysfunction following pyrithiamine induced thiamine deficiency in the rat AN - 1850772854; PQ0003896462 AB - Prolonged vitamin B1 (thiamine) deficiency can lead to neurological disorders such as Wernicke's encephalopathy and Wernicke-Korsakoff Syndrome (WKS) in humans. These thiamine deficiency disorders have been attributed to vascular leakage, blood-brain barrier breakdown and neuronal loss in the diencephalon and brain stem. However, endothelial dysfunction following thiamine deficiency and its relationship to the phenomenon of neurodegeneration has not been clearly elucidated. The present study sought to begin to address this issue by evaluating vascular morphology and integrity in a pyrithiamine (PT)-induced rat model of thiamine deficiency. Adjacent brain sections were used to either assess vascular integrity through immunohistochemical localization of rat endothelial cell antigen (RECA-1) and endothelial brain barrier antigen (EBA-1) or neurodegeneration using the de Olmos cupric silver method. GFAP and CD11b immunolabeling was used to evaluate astrocytic and microglial/macrophagic changes. Extensive neurodegeneration occurred concomitant with both vascular damage (thinning and breakage) and microglial activation in the inferior olive, medial thalamic area, and medial geniculate nuclei of pyrithiamine treated rats. Likewise, glucose transporter-1 (Glut-1), which is mostly expressed in endothelial cells, was also severely decreased in this pyrithiamine induced thiamine deficient rat model. MRI scans of these animals prior to sacrifice show that the pyrithiamine induced thiamine deficient animals have abnormal T2 relaxation values, which are commensurate with, and possibly predictive of, the neurodegeneration and/or endothelial dysfunction subsequently observed histologically in these same animals. JF - Neurotoxicology AU - Sarkar, Sumit AU - Liachenko, Serguei AU - Paule, Merle G AU - Bowyer, John AU - Hanig, Joseph P AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR-72079, USA Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 298 EP - 309 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 57 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Pyrithiamine KW - Endothelial cells KW - Astrocytes KW - Microglia KW - Neurodegeneration KW - pyrithiamine KW - Neurological diseases KW - Leakage KW - Blood-brain barrier KW - Magnetic resonance imaging KW - Brain stem KW - Glial fibrillary acidic protein KW - Thiamine KW - Thalamus KW - Diencephalon KW - Thinning KW - Nutrient deficiency KW - Vitamins KW - CD11b antigen KW - Wernicke's encephalopathy KW - Silver KW - N3 11028:Neuropharmacology & toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1850772854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Brain+endothelial+dysfunction+following+pyrithiamine+induced+thiamine+deficiency+in+the+rat&rft.au=Sarkar%2C+Sumit%3BLiachenko%2C+Serguei%3BPaule%2C+Merle+G%3BBowyer%2C+John%3BHanig%2C+Joseph+P&rft.aulast=Sarkar&rft.aufirst=Sumit&rft.date=2016-12-01&rft.volume=57&rft.issue=&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2016.10.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-21 N1 - SubjectsTermNotLitGenreText - pyrithiamine; Leakage; Neurological diseases; Blood-brain barrier; Brain stem; Magnetic resonance imaging; Thiamine; Glial fibrillary acidic protein; Neurodegeneration; Thalamus; Diencephalon; Endothelial cells; Thinning; Nutrient deficiency; CD11b antigen; Vitamins; Wernicke's encephalopathy; Silver DO - http://dx.doi.org/10.1016/j.neuro.2016.10.014 ER - TY - JOUR T1 - Depletion of florfenicol in lactating dairy cows after intramammary and subcutaneous administration AN - 1846409278; PQ0003816373 AB - Eighteen Holstein dairy cows ranging in body weight from 500-700 kg and with an average milk yield of 37 plus or minus 6 kg/day were used to investigate the depletion of florfenicol (FFL) in milk and plasma of dairy cows. Three groups of six were administered FFL: Group A, intramammary (IMM) infusion of ~2.5 mg FFL/kg BW at three consecutive milking intervals (total amount of ~7.5 mg/kg BW); Group B, one IMM infusion (20 mg/kg BW) into one quarter and Group C, one subcutaneous (SC) treatment (40 mg/kg BW). IMM infusions were into the right front quarter. Cows were milked daily at 06:00 and 18:00 h. The highest concentrations (C sub(max)) and time to C sub(max) (T sub(max)) were: 1.6 plus or minus 2.2 mu g.FFL/mL milk at 22 h (Group A), 5.5 plus or minus 3.6 mu g.FFL/mL milk at 12 h (Group B), and 1.7 plus or minus 0.4 mu g.FFL/mL milk at 12 h (Group C). The half-lives (t sub(1/2)) were ~19, 5.5, and 60 h, for Groups A, B, and C, respectively. FFL was below the limit of detection (LOD) by 60 h in three Group B cows, but above the LOD at 72, 84, and 120 h in three cows. FFL was above the LOD in milk from Group C's cows for 432-588 h. Plasma values followed the same trends as milk. The results demonstrate that IMM-infused FFL is bioavailable and below the LOD within 72-120 h. The concentration of FFL was detectable in both plasma and milk over the course of 2-3 weeks after SC administration. The absence of residue depletion data presents problems in determining safe levels of FFL residues in milk and edible tissues. The data presented here must not be construed as approval for extra-label use in food animals. JF - Journal of Veterinary Pharmacology and Therapeutics AU - Kawalek, J C AU - Howard, K D AU - Jones, Y AU - Scott, M L AU - Myers, MJ AD - Division of Applied Veterinary Research, U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, MD, USA. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 602 EP - 611 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 39 IS - 6 SN - 0140-7783, 0140-7783 KW - Biotechnology and Bioengineering Abstracts KW - Dairies KW - Data processing KW - Body weight KW - Food KW - Florfenicol KW - Milking KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846409278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.atitle=Depletion+of+florfenicol+in+lactating+dairy+cows+after+intramammary+and+subcutaneous+administration&rft.au=Kawalek%2C+J+C%3BHoward%2C+K+D%3BJones%2C+Y%3BScott%2C+M+L%3BMyers%2C+MJ&rft.aulast=Kawalek&rft.aufirst=J&rft.date=2016-12-01&rft.volume=39&rft.issue=6&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.issn=01407783&rft_id=info:doi/10.1111%2Fjvp.12315 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Dairies; Data processing; Body weight; Food; Milking; Florfenicol DO - http://dx.doi.org/10.1111/jvp.12315 ER - TY - JOUR T1 - Development of methods for using workers' compensation data for surveillance and prevention of occupational injuries among State-insured private employers in Ohio AN - 1846395255; PQ0003858697 AB - Background Workers' compensation (WC) claims data may be useful for identifying high-risk industries and developing prevention strategies. Methods WC claims data from private-industry employers insured by the Ohio state-based workers' compensation carrier from 2001 to 2011 were linked with the state's unemployment insurance (UI) data on the employer's industry and number of employees. National Labor Productivity and Costs survey data were used to adjust UI data and estimate full-time equivalents (FTE). Rates of WC claims per 100 FTE were computed and Poisson regression was used to evaluate differences in rates. Results Most industries showed substantial claim count and rate reductions from 2001 to 2008, followed by a leveling or slight increase in claim count and rate from 2009 to 2011. Despite reductions, there were industry groups that had consistently higher rates. Conclusion WC claims data linked to employment data could be used to prioritize industries for injury research and prevention activities among State-insured private employers. Am. J. Ind. Med. 59:1087-1104, 2016. JF - American Journal of Industrial Medicine AU - Wurzelbacher, Steven J AU - Al-Tarawneh, Ibraheem S AU - Meyers, Alysha R AU - Bushnell, PTimothy AU - Lampl, Michael P AU - Robins, David C AU - Tseng, Chih-Yu AU - Wei, Chia AU - Bertke, Stephen J AU - Raudabaugh, Jill A AU - Haviland, Thomas M AU - Schnorr, Teresa M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, Center for Workers' Compensation Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1087 EP - 1104 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 12 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Data processing KW - Injuries KW - Unemployment KW - Occupational safety KW - Employment KW - Insurance KW - Workers' compensation KW - Prevention KW - Labor productivity KW - Risk groups KW - USA, Ohio KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846395255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Development+of+methods+for+using+workers%27+compensation+data+for+surveillance+and+prevention+of+occupational+injuries+among+State-insured+private+employers+in+Ohio&rft.au=Wurzelbacher%2C+Steven+J%3BAl-Tarawneh%2C+Ibraheem+S%3BMeyers%2C+Alysha+R%3BBushnell%2C+PTimothy%3BLampl%2C+Michael+P%3BRobins%2C+David+C%3BTseng%2C+Chih-Yu%3BWei%2C+Chia%3BBertke%2C+Stephen+J%3BRaudabaugh%2C+Jill+A%3BHaviland%2C+Thomas+M%3BSchnorr%2C+Teresa+M&rft.aulast=Wurzelbacher&rft.aufirst=Steven&rft.date=2016-12-01&rft.volume=59&rft.issue=12&rft.spage=1087&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22653 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Data processing; Injuries; Risk groups; Workers' compensation; Prevention; Labor productivity; Unemployment; Occupational safety; Employment; Insurance; USA, Ohio DO - http://dx.doi.org/10.1002/ajim.22653 ER - TY - JOUR T1 - Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells. AN - 1846365584; 27613715 AB - Nefazodone, an antagonist for the 5-hydroxytryptanine receptor, has been used for the treatment of depression. Acute liver injury has been documented to be associated with the use of nefazodone; however, the mechanisms of nefazodone-induced liver toxicity are not well defined. In this report, using biochemical and molecular analyses, we characterized the molecular mechanisms underlying the hepatotoxicity of nefazodone. We found that nefazodone induced endoplasmic reticulum (ER) stress in HepG2 cells, as the expression of typical ER stress markers, including CHOP, ATF-4, and p-eIF2α, was significantly increased, and splicing of XBP1 was observed. Nefazodone-suppressed protein secretion was evaluated using a Gaussia luciferase reporter assay that measures ER stress. The ER stress inhibitors (4-phenylbutyrate and salubrinal) and knockdown of ATF-4 gene attenuated nefazodone-induced ER stress and cytotoxicity. Nefazodone activated the MAPK signaling pathway, as indicated by increased phosphorylation of JNK, ERK1/2, and p38. Inhibition of ERK1/2 reduced ER stress caused by nefazodone. Taken together, our findings suggest that ER stress contributes to nefazodone-induced toxicity in HepG2 cells and that the MAPK signaling pathway plays an important role in ER stress. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Ren, Zhen AU - Chen, Si AU - Zhang, Jie AU - Doshi, Utkarsh AU - Li, Albert P AU - Guo, Lei AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, Arkansas. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. FDA, Jefferson, Arkansas. ; In Vitro ADMET Laboratories LLC, Columbia, Maryland. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, Arkansas; Lei.Guo@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 368 EP - 380 VL - 154 IS - 2 KW - MAPK pathway KW - nefazodone. KW - reporter gene assay KW - drug-induced liver toxicity KW - endoplasmic reticulum stress (ER stress) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846365584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Endoplasmic+Reticulum+Stress+Induction+and+ERK1%2F2+Activation+Contribute+to+Nefazodone-Induced+Toxicity+in+Hepatic+Cells.&rft.au=Ren%2C+Zhen%3BChen%2C+Si%3BZhang%2C+Jie%3BDoshi%2C+Utkarsh%3BLi%2C+Albert+P%3BGuo%2C+Lei&rft.aulast=Ren&rft.aufirst=Zhen&rft.date=2016-12-01&rft.volume=154&rft.issue=2&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Battle in the New World: Helicoverpa armigera versus Helicoverpa zea (Lepidoptera: Noctuidae) AN - 1845257766 AB - The corn earworm Helicoverpa zea (Boddie) and the old world bollworm Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) are allopatric species and occur in important agricultural crops. In maize, both species tend to infest the ear. The introduction of H. armigera in Brazil has created a new scenario, where these Helicoverpa species might cohabit and interact with one another, affecting the prevalence of each species in the agroecosystem, integrated pest management, and insect resistance management. In this study, larval occurrence and proportion of these species in maize was assessed in three regions of Brazil during three crop seasons. Interaction between the species was evaluated in interspecific and intraspecific scenarios under laboratory and field conditions. Helicoverpa zea was predominant in Rio Grande do Sul and the Planaltina, DF (central Brazil). In western Bahia, H. zea was predominant in the first collection, but approximately equal in number to H armigera in the second crop season. Both species exhibit high cannibalism/predation rates, and larval size was the primary factor for larval survival in the interaction studies. Larva of H. zea had higher survival when interacting with H. armigera, indicating that H. zea has an advantage in intraguild interactions with H. armigera in maize. Overall, the results from this study indicate that maize might play a role as a source of infestation or a sink of insecticide or Bt protein unselected H. armigera populations, depending on the H. zea:H. armigera intraguild competition and adult movement in the landscape. JF - PLoS One AU - Bentivenha, José PF AU - Paula-Moraes, Silvana V AU - Baldin, Edson LL AU - Specht, Alexandre AU - Silva, Ivana Fda AU - Hunt, Thomas E Y1 - 2016/12// PY - 2016 DA - Dec 2016 CY - San Francisco PB - Public Library of Science VL - 11 IS - 12 KW - Sciences: Comprehensive Works KW - Insecticides KW - Proteins KW - Studies KW - Seasons KW - Corn KW - Butterflies & moths KW - Laboratories KW - Soybeans KW - United States--US KW - Florida UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1845257766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=Battle+in+the+New+World%3A+Helicoverpa+armigera+versus+Helicoverpa+zea+%28Lepidoptera%3A+Noctuidae%29&rft.au=Bentivenha%2C+Jos%C3%A9+PF%3BPaula-Moraes%2C+Silvana+V%3BBaldin%2C+Edson+LL%3BSpecht%2C+Alexandre%3BSilva%2C+Ivana+Fda%3BHunt%2C+Thomas+E&rft.aulast=Bentivenha&rft.aufirst=Jos%C3%A9&rft.date=2016-12-01&rft.volume=11&rft.issue=12&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pone.0167182 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Citation: Bentivenha JPF, Paula-Moraes SV, Baldin ELL, Specht A, da Silva IF, Hunt TE (2016) Battle in the New World: Helicoverpa armigera versus Helicoverpa zea (Lepidoptera: Noctuidae). PLoS ONE 11(12): e0167182. doi:10.1371/journal.pone.0167182 N1 - Last updated - 2016-12-03 N1 - SubjectsTermNotLitGenreText - Florida; United States--US DO - http://dx.doi.org/10.1371/journal.pone.0167182 ER - TY - JOUR T1 - Stability of core language skill across the first decade of life in children at biological and social risk AN - 1845015267 AB - Background Command of language is a fundamental skill, a cornerstone of multiple cognitive and socioemotional aspects of development, and a necessary ingredient of successful adjustment and functioning in society. Little is known about the developmental stability of language in at-risk youth or which biological and social risk factors moderate stability. Methods This four-wave 10-year prospective longitudinal study evaluated stability of core language skill in 1,780 children in varying categories of biological and social risk in a multiage, multidomain, multimeasure, and multireporter framework. Results Structural equation modeling supported loadings of diverse age-appropriate measures of child language on single latent variables of core language skill at 15 and 25 months and 5 and 11 years, respectively. Core language skill was stable over the first decade of life; significant and comparable stability coefficients were obtained for children with diverse biological and social risks, including poor health, welfare status, teen motherhood, ethnicity, gender, birth order, and families that changed in income and maternal education over the study period; stability in language was strong even accounting for child nonverbal intelligence and social competence, maternal education and language, and the family home environment. Conclusions Core language skill varies in stability with age but is robustly stable in children regardless of multiple biological and social risk factors. JF - Journal of Child Psychology and Psychiatry AU - Bornstein, Marc H AU - Hahn, Chun-Shin AU - Putnick, Diane L AD - Child and Family Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Public Health Service, Bethesda, MD, USA ; Child and Family Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Public Health Service, Bethesda, MD, USA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 1434 EP - 1443 CY - Malden PB - Wiley Subscription Services, Inc. VL - 57 IS - 12 KW - Psychology KW - At risk KW - Intelligence KW - Birth order KW - Socioemotional aspects KW - Home environment KW - Risk factors KW - Ethnicity KW - Health status KW - Welfare KW - Social competence KW - Motherhood KW - Nonverbal intelligence KW - Adolescent motherhood KW - Childbirth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1845015267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Stability+of+core+language+skill+across+the+first+decade+of+life+in+children+at+biological+and+social+risk&rft.au=Bornstein%2C+Marc+H%3BHahn%2C+Chun-Shin%3BPutnick%2C+Diane+L&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2016-12-01&rft.volume=57&rft.issue=12&rft.spage=1434&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Psychology+and+Psychiatry&rft.issn=&rft_id=info:doi/10.1111%2Fjcpp.12632 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © 2016 Association for Child and Adolescent Mental Health. N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1111/jcpp.12632 ER - TY - JOUR T1 - An Examination of Hospital Nurse Staffing and Patient Experience with Care: Differences between Cross-Sectional and Longitudinal Estimates AN - 1844983395 AB - Objective To study the association between hospital nurse staffing and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) scores. Data Sources State hospital financial and utilization reports, Healthcare Cost and Utilization Project State Inpatient Databases, HCAHPS survey, and American Hospital Association Annual Survey of Hospitals. Study Design Retrospective study using cross-sectional and longitudinal models to estimate the effect of nurse staffing levels and skill mix on seven HCAHPS measures. Data Collection/Extraction Methods Hospital-level data measuring nurse staffing, patient experience, and hospital characteristics from 2009 to 2011 for 341 hospitals (977 hospital years) in California, Maryland, and Nevada. Principal Findings Nurse staffing level (i.e., number of licensed practical nurses and registered nurses per 1,000 inpatient days) was significantly and positively associated with all seven HCAHPS measures in cross-sectional models and three of seven measures in longitudinal models. Nursing skill mix (i.e., percentage of all staff who are registered nurses) was significantly and negatively associated with scores on one measure in cross-sectional models and none in longitudinal models. Conclusions After controlling for unobserved hospital characteristics, the positive influences of increased nurse staffing levels and skill mix were relatively small in size and limited to a few measures of patients' inpatient experience. JF - Health Services Research AU - Martsolf, Grant R AU - Gibson, Teresa B AU - Benevent, Richele AU - Jiang, H Joanna AU - Stocks, Carol AU - Ehrlich, Emily D AU - Kandrack, Ryan AU - Auerbach, David I AD - RAND Corporation, Pittsburgh, PA ; Health Outcomes Research, Truven Health Analytics, Ann Arbor, MI ; Health Outcomes Research, Truven Health Analytics, Santa Barbara, CA ; Center for Delivery, Organization and Markets, Agency for Healthcare Research and Quality, Rockville, MD ; Health Research Division, Mathematica Policy Research, Ann Arbor, MI ; Center for Interdisciplinary Health Workforce Studies at Montana State University, Bozeman, MT ; RAND Corporation, Pittsburgh, PA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 2221 EP - 2241 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 51 IS - 6 SN - 0017-9124 KW - Medical Sciences KW - Surveys KW - Databases KW - Health costs KW - Practice nurses KW - Staffing KW - Staffing levels KW - Patient care KW - Health care industry KW - Extraction KW - Hospitalization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844983395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=An+Examination+of+Hospital+Nurse+Staffing+and+Patient+Experience+with+Care%3A+Differences+between+Cross-Sectional+and+Longitudinal+Estimates&rft.au=Martsolf%2C+Grant+R%3BGibson%2C+Teresa+B%3BBenevent%2C+Richele%3BJiang%2C+H+Joanna%3BStocks%2C+Carol%3BEhrlich%2C+Emily+D%3BKandrack%2C+Ryan%3BAuerbach%2C+David+I&rft.aulast=Martsolf&rft.aufirst=Grant&rft.date=2016-12-01&rft.volume=51&rft.issue=6&rft.spage=2221&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12462 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1111/1475-6773.12462 ER - TY - JOUR T1 - Paving the Way for Progress: The Agency for Healthcare Research and Quality Patient Safety and Medical Liability Demonstration Initiative AN - 1844981942 JF - Health Services Research AU - Battles, James B AU - Reback, Kathryn A AU - Azam, Irim AD - Agency for Healthcare Research and Quality, Rockville, MD ; Agency for Healthcare Research and Quality, Rockville, MD Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 2401 EP - 2413 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 51 IS - S3 SN - 0017-9124 KW - Medical Sciences KW - Health care KW - Medical research KW - Liability KW - Patient care KW - Safety measures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1844981942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Paving+the+Way+for+Progress%3A+The+Agency+for+Healthcare+Research+and+Quality+Patient+Safety+and+Medical+Liability+Demonstration+Initiative&rft.au=Battles%2C+James+B%3BReback%2C+Kathryn+A%3BAzam%2C+Irim&rft.aulast=Battles&rft.aufirst=James&rft.date=2016-12-01&rft.volume=51&rft.issue=S3&rft.spage=2401&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12632 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.1111/1475-6773.12632 ER - TY - JOUR T1 - Bullying and Victimization Among Young Elementary School Children: The Role of Child Ethnicity and Ethnic School Composition AN - 1842450147 AB - School-aged children with an ethnic minority background are relatively often involved in bullying and victimization, but the role of ethnic composition of schools in this context remains unclear. This study examined the relation between ethnic minority background, ethnic school composition, and bullying behaviour around primary school entry in the Netherlands. The study was based on a 2008/2009 school survey in Rotterdam, a Dutch city where about 50 % of children have a non-Dutch background. For 8523 children, teacher reports of bullying behaviour at age 5-6 years were available. Children with a non-Dutch background had higher odds of being a victim (adjusted OR 1.41, 95 % CI 1.11, 1.80), bully (OR 1.38, 95 % CI 1.20, 1.58) or bully-victim (OR 1.38, 95 % CI 1.19, 1.62) than children of Dutch national origin. Ethnic diversity in schools increased children's risk of bullying behaviour (e.g. ORvictim per 0.1 increase in 0-1 diversity range = 1.06, 95 % CI 1.00, 1.13), with children of both Dutch and non-Dutch national origin relatively more often involved in bullying in ethnically diverse schools. The proportion of same-ethnic peers in school reduced the risk of bullying among children of Dutch national origin (e.g. ORvictim per 10 % more same-ethnic children = 0.90, 95 % CI 0.83, 0.98), but not among non-Dutch children. In conclusion, ethnic minority background and ethnic diversity within schools are risk factors for bullying among 5-6 year olds. Plausibly, reductions in absolute numbers of bullying events may be obtained with tailor-made interventions in ethnically diverse schools. Such interventions should preferably be offered early in the school curriculum. JF - Race and Social Problems AU - Jansen, Pauline W AU - Mieloo, Cathelijne L AU - Dommisse-van Berkel, Anke AU - Verlinden, Marina AU - van der Ende, Jan AU - Stevens, Gonneke AU - Verhulst, Frank C AU - Jansen, Wilma AU - Tiemeier, Henning AD - Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands; Institute of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands ; Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands; Department of Public Health, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands ; Municipal Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands; The Generation R Study Group, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands ; Utrecht Centre of Child and Adolescent Studies, Utrecht University, Utrecht, The Netherlands ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Psychiatry, Erasmus MC-University Medical Center Rotterdam, Rotterdam, The Netherlands ; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC-University Medical Center Rotterdam, PO BOX 2060, Rotterdam, The Netherlands; Institute of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 271 EP - 280 CY - New York PB - Springer Science & Business Media VL - 8 IS - 4 SN - 1867-1748 KW - Social Sciences: Comprehensive Works KW - Bullying KW - Victimization KW - Ethnicity KW - Ethnic diversity KW - School KW - Child KW - Minority Groups KW - Cultural Pluralism KW - Aggression KW - Victims KW - Risk Factors KW - Peers KW - Ethnic Groups KW - Elementary Schools KW - Curriculum KW - Children KW - Elderly KW - Schools UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842450147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Race+and+Social+Problems&rft.atitle=Bullying+and+Victimization+Among+Young+Elementary+School+Children%3A+The+Role+of+Child+Ethnicity+and+Ethnic+School+Composition&rft.au=Jansen%2C+Pauline+W%3BMieloo%2C+Cathelijne+L%3BDommisse-van+Berkel%2C+Anke%3BVerlinden%2C+Marina%3Bvan+der+Ende%2C+Jan%3BStevens%2C+Gonneke%3BVerhulst%2C+Frank+C%3BJansen%2C+Wilma%3BTiemeier%2C+Henning&rft.aulast=Jansen&rft.aufirst=Pauline&rft.date=2016-12-01&rft.volume=8&rft.issue=4&rft.spage=271&rft.isbn=&rft.btitle=&rft.title=Race+and+Social+Problems&rft.issn=18671748&rft_id=info:doi/10.1007%2Fs12552-016-9182-9 LA - English DB - Social Services Abstracts; Sociological Abstracts N1 - Copyright - Race and Social Problems is a copyright of Springer, 2016. N1 - Last updated - 2017-01-27 DO - http://dx.doi.org/10.1007/s12552-016-9182-9 ER - TY - JOUR T1 - Pharmacodynamic study of the oral hedgehog pathway inhibitor, vismodegib, in patients with metastatic castration-resistant prostate cancer. AN - 1839107218; 27826729 AB - Hedgehog (Hh) pathway signaling has been implicated in prostate cancer tumorigenesis and metastatic development and may be upregulated even further in the castration-resistant state. We hypothesized that antagonism of the Hh pathway with vismodegib in men with metastatic castration-resistant prostate cancer (mCRPC) would result in pathway engagement, inhibition and perhaps induce measurable clinical responses in patients. This is a single-arm study of oral daily vismodegib in men with mCRPC. All patients were required to have biopsies of the tumor and skin (a surrogate tissue) at baseline and after 4 weeks of therapy. Ten patients were planned for enrollment. The primary outcome was the pharmacodynamic assessment of Gli1 mRNA suppression with vismodegib in tumor tissue. Secondary outcomes included PSA response rates, progression-free survival (PFS), overall survival (OS) and safety. Nine patients were enrolled. Gli1 mRNA was significantly suppressed by vismodegib in both tumor tissue (4/7 evaluable biopsies, 57%) and benign skin biopsies (6/8 evaluable biopsies, 75%). The median number of treatment cycles completed was three, with a median PFS of 1.9 months (95% CI 1.3, NA), and a median OS of 7.04 months (95% CI 3.4, NA). No patient achieved a PSA reduction or a measurable tumor response. Safety data were consistent with the known toxicities of vismodegib. Hh signaling, as measured by Gli1 mRNA expression in mCRPC tissues, was suppressed with vismodegib in the majority of patients. Despite this pharmacodynamic response that indicated target inhibition in some patients, there was no apparent signal of clinical activity. Vismodegib will not be developed further as monotherapy in mCRPC. JF - Cancer chemotherapy and pharmacology AU - Maughan, Benjamin L AU - Suzman, Daniel L AU - Luber, Brandon AU - Wang, Hao AU - Glavaris, Stephanie AU - Hughes, Robert AU - Sullivan, Rana AU - Harb, Rana AU - Boudadi, Karim AU - Paller, Channing AU - Eisenberger, Mario AU - Demarzo, Angelo AU - Ross, Ashely AU - Antonarakis, Emmanuel S AD - Huntsman Cancer Center, University of Utah, 2000 Circle of Hope Dr, Salt Lake City, UT, 84112, USA. ; Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993, USA. ; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans St. CRB1 1M45, Baltimore, MD, 21287, USA. ; Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, 1650 Orleans St. CRB1 1M45, Baltimore, MD, 21287, USA. eantona1@jhmi.edu. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1297 EP - 1304 VL - 78 IS - 6 KW - Gli KW - Hedgehog KW - Metastatic castration-resistant prostate cancer KW - Vismodegib UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1839107218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Pharmacodynamic+study+of+the+oral+hedgehog+pathway+inhibitor%2C+vismodegib%2C+in+patients+with+metastatic+castration-resistant+prostate+cancer.&rft.au=Maughan%2C+Benjamin+L%3BSuzman%2C+Daniel+L%3BLuber%2C+Brandon%3BWang%2C+Hao%3BGlavaris%2C+Stephanie%3BHughes%2C+Robert%3BSullivan%2C+Rana%3BHarb%2C+Rana%3BBoudadi%2C+Karim%3BPaller%2C+Channing%3BEisenberger%2C+Mario%3BDemarzo%2C+Angelo%3BRoss%2C+Ashely%3BAntonarakis%2C+Emmanuel+S&rft.aulast=Maughan&rft.aufirst=Benjamin&rft.date=2016-12-01&rft.volume=78&rft.issue=6&rft.spage=1297&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Outcomes for a Public Hospital Tobacco Cessation Program: The Cook County Health and Hospitals System Experience AN - 1837315645; PQ0003812660 AB - The objective of this study is to determine the rate and predictors of sustained smoking cessation for a cohort of smokers exposed to a guideline-based health education program delivered during routine clinical care at an urban public hospital. This is a retrospective analysis of 755 public hospital system patients who had at least two health educator contacts embedded in routine clinical care, with the latter contact 12-18 months after the baseline. The education occurred during visits to primary care, specialty clinics, urgent/episodic care, or during hospitalization. The assessment of smoking status is determined by the health educators as part of their routine assessment and recorded in the program's database. The primary outcomes are self-reported 12-month sustained smoking cessation at the 12-18 month contact and predictors of cessation. The cohort is predominantly minority smokers (African American 69 % and Latino 15 %) and uninsured (70 %) or on Medicaid (13 %). The sustained cessation rate was 9.3 %. Latino ethnicity, smoking 1-9 cigarettes/day at baseline, reporting smoke-free home, and additional educator contact in the year after the baseline were independent predictors of sustained cessation in the multivariate analysis. Smokers with multiple risks for poor cessation outcomes exposed to a guideline-based program of health education during routine healthcare encounters had sustained smoking cessation rates that compare favorably with published National Health Interview Study population cessation rates. An additional educator contact after the baseline was a predictor of cessation. The findings support development of cessation programs in which health educators are integrated into clinical care settings. JF - Journal of Community Health AU - Goldberg, David N AU - Krantz, Anne J AU - Semal, Sara AU - Zhang, Huiyuan AU - Trick, William E AD - Division of General Internal Medicine, Cook County Health and Hospitals System, Chicago, IL, USA, david.goldberg@ihs.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1130 EP - 1139 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 41 IS - 6 SN - 0094-5145, 0094-5145 KW - Health & Safety Science Abstracts KW - Risk assessment KW - Cigarettes KW - Health care KW - Cigarette smoking KW - Tobacco KW - Socioeconomics KW - Ethnic groups KW - Data bases KW - Hospitals KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837315645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Community+Health&rft.atitle=Outcomes+for+a+Public+Hospital+Tobacco+Cessation+Program%3A+The+Cook+County+Health+and+Hospitals+System+Experience&rft.au=Goldberg%2C+David+N%3BKrantz%2C+Anne+J%3BSemal%2C+Sara%3BZhang%2C+Huiyuan%3BTrick%2C+William+E&rft.aulast=Goldberg&rft.aufirst=David&rft.date=2016-12-01&rft.volume=41&rft.issue=6&rft.spage=1130&rft.isbn=&rft.btitle=&rft.title=Journal+of+Community+Health&rft.issn=00945145&rft_id=info:doi/10.1007%2Fs10900-016-0215-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 46 N1 - Last updated - 2016-11-23 N1 - SubjectsTermNotLitGenreText - Risk assessment; Health care; Cigarettes; Cigarette smoking; Tobacco; Socioeconomics; Data bases; Ethnic groups; Hospitals DO - http://dx.doi.org/10.1007/s10900-016-0215-5 ER - TY - JOUR T1 - Effects of maternal silver acetate exposure on immune biomarkers in a rodent model. AN - 1835689543; 27789322 AB - Male and female rats (26-day old) were exposed to 0.0, 0.4, 4 or 40 mg/kg body weight silver acetate (AgAc) in drinking water for 10 weeks prior to and during mating. Sperm positive females remained within their dose groups and were exposed to AgAc during gestation and lactation. Splenic and thymic lymphocyte subsets from F1 generation PD (postnatal day) 4 and 26 pups were assessed by flow cytometry for changes in phenotypic markers. Spleens from PD4 pups had lower percentages of CD8+ lymphocytes in 4 and 40 mg/kg AgAc exposed groups and reduced Concanavalin A (Con A) response at all AgAc exposure groups. Splenic maturation increased in PD26 pups compared to PD4 pups. Con A and lipopolysaccharide (LPS) mediated splenic responses were lower in PD26 pups exposed to 40 mg/kg AgAc. Changes in PD 26 pup splenocyte phenotypic markers included lower TCR + cells at 4 and 40 mg/kg AgAc exposure and higher B cell population in the 40 mg/kg AgAc. PD26 pup splenic natural killer cell (NK) activity was higher in the 0.4 AgAc group and unchanged in 4 and 40 mg/kg AgAc groups. In conclusion, maternal exposure to AgAc had a significant impact on rat splenic development during the early lactation period. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Babu, Uma S AU - Balan, Kannan V AU - Bigley, Elmer AU - Pereira, Marion AU - Black, Thomas AU - Olejnik, Nicholas AU - Keltner, Zachary AU - Sprando, Robert L AD - Division of Virulence Assessment, Office of Applied Research and Safety Assessment, CFSAN, U.S. FDA, Laurel, MD, United States. Electronic address: uma.babu@fda.hhs.gov. ; Division of Virulence Assessment, Office of Applied Research and Safety Assessment, CFSAN, U.S. FDA, Laurel, MD, United States. ; Division of Toxicology, Office of Applied Research and Safety Assessment, CFSAN, U.S. FDA, Laurel, MD, United States. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 195 EP - 200 VL - 98 KW - Silver acetate KW - Natural killer cell activity KW - Maternal exposure KW - Rodent model KW - Immune biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835689543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Effects+of+maternal+silver+acetate+exposure+on+immune+biomarkers%C2%A0in%C2%A0a%C2%A0rodent+model.&rft.au=Babu%2C+Uma+S%3BBalan%2C+Kannan+V%3BBigley%2C+Elmer%3BPereira%2C+Marion%3BBlack%2C+Thomas%3BOlejnik%2C+Nicholas%3BKeltner%2C+Zachary%3BSprando%2C+Robert+L&rft.aulast=Babu&rft.aufirst=Uma&rft.date=2016-12-01&rft.volume=98&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.10.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.10.022 ER - TY - GEN T1 - Editorial: MicroRNAs in toxicology and medicine: A special issue of the journal "Food and Chemical Toxicology". AN - 1835689154; 27523293 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Sahu, Saura C Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1 VL - 98 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835689154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Global+analysis+of+posttranscriptional+gene+expression+in+response+to+sodium+arsenite.&rft.au=Qiu%2C+Lian-Qun%3BAbey%2C+Sarah%3BHarris%2C+Shawn%3BShah%2C+Ruchir%3BGerrish%2C+Kevin+E%3BBlackshear%2C+Perry+J&rft.aulast=Qiu&rft.aufirst=Lian-Qun&rft.date=2015-04-01&rft.volume=123&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408626 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.08.015 ER - TY - JOUR T1 - MicroRNA-mediated maturation of human pluripotent stem cell-derived cardiomyocytes: Towards a better model for cardiotoxicity? AN - 1835677789; 27265266 AB - Human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) are a promising human cardiac model system for drug development and toxicity screening, along with cell therapy and mechanistic research. The scalable differentiation of human PSCs into CMs provides a renewable cell source that overcomes species differences present in rodent primary CMs. In addition, induced pluripotent stem cell (iPSC) technology allows for development of patient-specific CMs, representing a valuable tool that may lead to better prediction, prevention, and treatment of cardiovascular diseases in this new era of precision medicine. However, the utility of PSC-CMs as an in vitro model is currently limited by their immature phenotype when compared to adult CMs. Recent work has identified microRNAs (miRNAs) as critical regulators of heart development and function. These studies have shown that miRNAs are essential to key processes that span the life cycle of a cardiomyocyte, including proliferation, hypertrophy, beating rhythm, and apoptosis. Importantly, emerging evidence strongly suggests that modulation of select miRNAs can enhance the maturation of PSC-CMs. Here, we review key miRNAs associated with heart development and function, and discuss strategies to promote PSC-CM maturation, focusing on current knowledge surrounding miRNA-based approaches and the application of PSC-CMs with respect to drug screening and disease models. Ultimately, it is likely that combinations of both miRNA and non-miRNA maturation strategies may collectively provide the best path forward for producing mature cardiomyocytes in vitro. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - White, Matthew C AU - Pang, Li AU - Yang, Xi AD - Division of Systems Biology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA. ; Division of Systems Biology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA. Electronic address: Xi.Yang@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 17 EP - 24 VL - 98 KW - Maturation KW - Cardiomyocytes KW - MicroRNA KW - Human pluripotent stem cells KW - Disease modeling KW - Cardiotoxicity KW - Drug screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835677789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=MicroRNA-mediated+maturation+of+human+pluripotent+stem+cell-derived+cardiomyocytes%3A+Towards+a+better+model+for+cardiotoxicity%3F&rft.au=White%2C+Matthew+C%3BPang%2C+Li%3BYang%2C+Xi&rft.aulast=White&rft.aufirst=Matthew&rft.date=2016-12-01&rft.volume=98&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.05.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.05.025 ER - TY - JOUR T1 - Effect of smokeless tobacco products on human oral bacteria growth and viability. AN - 1835495884; 27756619 AB - To evaluate the toxicity of smokeless tobacco products (STPs) on oral bacteria, seven smokeless tobacco aqueous extracts (STAEs) from major brands of STPs and three tobacco-specific N-nitrosamines (TSNAs) were used in a growth and viability test against 38 oral bacterial species or subspecies. All seven STAEs showed concentration-dependent effects on the growth and viability of tested oral bacteria under anaerobic culture conditions, although there were strain-to-strain variations. In the presence of 1 mg/ml STAEs, the growth of 4 strains decreased over 0.32-2.14 log10 fold, while 14 strains demonstrated enhanced growth of 0.3-1.76 log10 fold, and the growth of 21 strains was not significantly affected. In the presence of 10 mg/ml STAEs, the growth of 17 strains was inhibited 0.3-2.11 log10 fold, 18 strains showed enhanced growth of 0.3-0.97 log10 fold, and 4 strains were not significantly affected. In the presence of 50 mg/ml STAEs, the growth of 32 strains was inhibited 0.3-2.96 log10 fold, 8 strains showed enhanced growth of 0.3-1.0 log10 fold, and 2 strains were not significantly affected. All seven STAEs could promote the growth of 4 bacterial strains, including Eubacterium nodatum, Peptostreptococcus micros, Streptococcus anginosus, and Streptococcus constellatus. Exposure to STAEs modulated the viability of some bacterial strains, with 21.1-66.5% decrease for 4 strains at 1 mg/ml, 20.3-85.7% decrease for 10 strains at 10 mg/ml, 20.0-93.3% decrease for 27 strains at 50 mg/ml, and no significant effect for 11 strains at up to 50 mg/ml. STAEs from snuffs inhibited more tested bacterial strains than those from snus indicating that the snuffs may be more toxic to the oral bacteria than snus. For TSNAs, cell growth and viability of 34 tested strains were not significantly affected at up to 100 μg/ml; while the growth of P. micros was enhanced 0.31-0.54 log10 fold; the growth of Veillonella parvula was repressed 0.33-0.36 log10 fold; and the cell viabilities of 2 strains decreased 56.6-69.9%. The results demonstrate that STAEs affected the growth of some types of oral bacteria, which may affect the healthy ecological balance of oral bacteria in humans. On the other hand, TSNAs did not significantly affect the growth of the oral bacteria. Published by Elsevier Ltd. JF - Anaerobe AU - Liu, Min AU - Jin, Jinshan AU - Pan, Hongmiao AU - Feng, Jinhui AU - Cerniglia, Carl E AU - Yang, Maocheng AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States; Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States; Key Laboratory of Marine Ecology & Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States; National Engineering Laboratory for Industrial Enzymes, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. ; Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993, United States. Electronic address: Maocheng.Yang@fda.hhs.gov. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, United States. Electronic address: Huizhong.Chen@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 152 EP - 161 VL - 42 KW - Complex Mixtures KW - 0 KW - Culture Media KW - Nitrosamines KW - Index Medicus KW - Smokeless tobacco KW - Oral bacteria KW - Cell viability KW - Toxicology KW - Tobacco-specific N-nitrosamines KW - Streptococcus anginosus -- isolation & purification KW - Veillonella -- drug effects KW - Humans KW - Hydrogen-Ion Concentration KW - Peptostreptococcus -- isolation & purification KW - Streptococcus anginosus -- drug effects KW - Streptococcus constellatus -- physiology KW - Eubacterium -- isolation & purification KW - Peptostreptococcus -- drug effects KW - Streptococcus constellatus -- drug effects KW - Streptococcus anginosus -- physiology KW - Streptococcus constellatus -- isolation & purification KW - Eubacterium -- physiology KW - Eubacterium -- drug effects KW - Microbial Viability -- drug effects KW - Veillonella -- physiology KW - Species Specificity KW - Peptostreptococcus -- physiology KW - Veillonella -- isolation & purification KW - Culture Media -- chemistry KW - Nitrosamines -- pharmacology KW - Microbiota -- drug effects KW - Complex Mixtures -- pharmacology KW - Microbiota -- physiology KW - Tobacco, Smokeless -- analysis KW - Mouth -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835495884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Effect+of+smokeless+tobacco+products+on+human+oral+bacteria+growth+and+viability.&rft.au=Liu%2C+Min%3BJin%2C+Jinshan%3BPan%2C+Hongmiao%3BFeng%2C+Jinhui%3BCerniglia%2C+Carl+E%3BYang%2C+Maocheng%3BChen%2C+Huizhong&rft.aulast=Liu&rft.aufirst=Min&rft.date=2016-12-01&rft.volume=42&rft.issue=&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=1095-8274&rft_id=info:doi/10.1016%2Fj.anaerobe.2016.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-16 N1 - Date created - 2016-10-19 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1016/j.anaerobe.2016.10.006 ER - TY - JOUR T1 - Health risk assessment of the intake of butyltin and phenyltin compounds from fish and seafood in Taiwanese population. AN - 1835358639; 27632793 AB - Organotin compounds have been applied as stabilizers for PVCs, fungicides, and pesticides, those can enter water systems through antifouling paints on ships as well as from diverse industrial and agricultural processes. This study aims to monitor the background levels of six organotins in 200 fishery products. In the current study, the high organotin levels are over tolerable average residue levels in Taiwan. Phenyltins (PTs) levels in fish and seafood are higher than butyltins (BTs). Risk assessment showed that 95% upper confidence limits of the hazard index (HI) of organotins were almost all over 1, indicating that there are probability of health impacts for organotin consumption in Taiwanese consumers. Those who consume higher amounts of seafood and fishery may be at a higher risk of health issues, but the data indicate that organotin levels have become controlled in recent years as compared with health risk data published in 2006. JF - Chemosphere AU - Lee, Ching-Chang AU - Hsu, Ya-Chen AU - Kao, Yi-Ting AU - Chen, Hsiu-Ling AD - Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, Tainan, Taiwan; Environmental Trace Toxic Substances Research Center, Medical College, National Cheng Kung University, Tainan, Taiwan. ; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, Taiwan. ; Institute of Occupational Safety and Hazard Prevention, Hung Kuang University, Taichung, Taiwan. Electronic address: hsiulin@sunrise.hk.edu.tw. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 568 EP - 575 VL - 164 KW - Risk assessment KW - Phenyltins KW - Tolerable average residue level KW - Organotins KW - Butyltins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835358639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Health+risk+assessment+of+the+intake+of+butyltin+and+phenyltin+compounds+from+fish+and+seafood+in+Taiwanese+population.&rft.au=Lee%2C+Ching-Chang%3BHsu%2C+Ya-Chen%3BKao%2C+Yi-Ting%3BChen%2C+Hsiu-Ling&rft.aulast=Lee&rft.aufirst=Ching-Chang&rft.date=2016-12-01&rft.volume=164&rft.issue=&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2016.08.141 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-15 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1016/j.chemosphere.2016.08.141 ER - TY - JOUR T1 - Effects of a 28-day dietary co-exposure to melamine and cyanuric acid on the levels of serum microRNAs in male and female Fisher 344 rats. AN - 1835001675; 27621052 AB - We showed previously that a 28-day combined dietary exposure to melamine and cyanuric acid (MEL&CYA) induced kidney lesions in NCTR Fisher 344 (F344) rats. Histopathological changes were significant in females dosed with ≥240 ppm MEL&CYA and in males dosed with ≥180 ppm MEL&CYA; however, the nephrotoxicity biomarkers blood urea nitrogen (BUN) and serum creatinine (SCr) were increased only by ≥240 ppm MEL&CYA. The serum miRNome has been reported to reflect toxicity of several organs, including the kidney. Here, we compared the dose-response of alterations in serum miRNAs to those of BUN, SCr, and kidney histopathology in rats co-exposed to MEL&CYA. The serum miRNome of male F344 rats dosed with 0, 180, or 240 ppm MEL&CYA was screened using quantitative real-time RT-PCR (qRT-PCR) and the levels of selected serum miRNAs were analyzed further in both sexes over the full dose range. The levels of several miRNAs were significantly reduced in rats treated with 240 ppm MEL&CYA versus control. In addition, miR-128-3p and miR-210-3p were decreased in males treated with 180pm MEL&CYA, a dose at which the levels of BUN and SCr were not yet affected by treatment. These data suggest that the serum miRNome is affected by nephrotoxic doses of MEL&CYA in male and female rats. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Silva, Camila S AU - Chang, Ching-Wei AU - Williams, Denita AU - Porter-Gill, Patricia AU - Gamboa da Costa, Gonçalo AU - Camacho, Luísa AD - Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: luisa.camacho@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 11 EP - 16 VL - 98 KW - SCr KW - Melamine KW - Kidney KW - Cyanuric acid KW - BUN KW - Serum miRNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835001675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=FDA+approval%3A+idelalisib+monotherapy+for+the+treatment+of+patients+with+follicular+lymphoma+and+small+lymphocytic+lymphoma.&rft.au=Miller%2C+Barry+W%3BPrzepiorka%2C+Donna%3Bde+Claro%2C+R+Angelo%3BLee%2C+Kyung%3BNie%2C+Lei%3BSimpson%2C+Natalie%3BGudi%2C+Ramadevi%3BSaber%2C+Haleh%3BShord%2C+Stacy%3BBullock%2C+Julie%3BMarathe%2C+Dhananjay%3BMehrotra%2C+Nitin%3BHsieh%2C+Li+Shan%3BGhosh%2C+Debasis%3BBrown%2C+Janice%3BKane%2C+Robert+C%3BJustice%2C+Robert%3BKaminskas%2C+Edvardas%3BFarrell%2C+Ann+T%3BPazdur%2C+Richard&rft.aulast=Miller&rft.aufirst=Barry&rft.date=2015-04-01&rft.volume=21&rft.issue=7&rft.spage=1525&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-2522 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.09.013 ER - TY - JOUR T1 - Chronic Health Conditions, Physical Activity and Dietary Behaviors of Bhutanese Refugees: A Houston-Based Needs Assessment AN - 1829718310 AB - Bhutanese refugees resettling in the U.S. face many challenges including several related to health and health care. Limited health literacy and the relatively complicated US health care system may contribute to health disparities as well. A health assessment was conducted on adult refugees in Houston, Texas to provide healthcare providers, community organizations, and stakeholders baseline data to plan programs and interventions. A convenience sample of 100 participants had a mean age of 38.37 years, 56 % where males, and almost 80 % did not have high school level education. High blood pressure (27 %), dizziness (27 %), and arthritis (22 %) were the commonly identified chronic health conditions and trouble concentrating (34 %) and fatigue (37 %) were also reported. Sixty-two percent of the respondents reported that they consume recommended servings of fruits and vegetables and 41 %reported that they were currently getting at least 20-30 min of aerobic exercise per day. The assessment concluded with recommendations on how better provide care and services for the refugees. JF - Journal of Immigrant and Minority Health AU - Misra, Sanghamitra M AU - Nepal, Vishnu P AU - Banerjee, Deborah AU - Giardino, Angelo P AD - Academic General Pediatrics, Baylor College of Medicine, Houston, TX, USA; Pediatrics, Texas Children's Hospital, Houston, TX, USA ; Department of Health and Human Services, City of Houston, Houston, TX, USA ; Academic General Pediatrics, Baylor College of Medicine, Houston, TX, USA; Pediatrics, Texas Children's Hospital, Houston, TX, USA Y1 - 2016/12// PY - 2016 DA - Dec 2016 SP - 1423 EP - 1431 CY - New York PB - Springer Science & Business Media VL - 18 IS - 6 SN - 1557-1912 KW - Medical Sciences KW - Refugees KW - Bhutanese KW - Needs assessment KW - Healthy food KW - Hypertension KW - Vegetables KW - Physical activity KW - Assessment KW - Health inequalities KW - Fatigue KW - Arthritis KW - Health education KW - Literacy KW - Community organizations KW - Dizziness KW - Health status KW - Men KW - Chronic sickness KW - Health care industry KW - Blood pressure KW - Aerobic exercise KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1829718310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Chronic+Health+Conditions%2C+Physical+Activity+and+Dietary+Behaviors+of+Bhutanese+Refugees%3A+A+Houston-Based+Needs+Assessment&rft.au=Misra%2C+Sanghamitra+M%3BNepal%2C+Vishnu+P%3BBanerjee%2C+Deborah%3BGiardino%2C+Angelo+P&rft.aulast=Misra&rft.aufirst=Sanghamitra&rft.date=2016-12-01&rft.volume=18&rft.issue=6&rft.spage=1423&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-015-0282-1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-10-18 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1007/s10903-015-0282-1 ER - TY - JOUR T1 - Sensitive detection of influenza viruses with Europium nanoparticles on an epoxy silica sol-gel functionalized polycarbonate-polydimethylsiloxane hybrid microchip AN - 1827908065; PQ0003662347 AB - In an effort to develop new tools for diagnosing influenza in resource-limited settings, we fabricated a polycarbonate (PC)-polydimethylsiloxane (PDMS) hybrid microchip using a simple epoxy silica sol-gel coating/bonding method and employed it in sensitive detection of influenza virus with Europium nanoparticles (EuNPs). The incorporation of sol-gel material in device fabrication provided functionalized channel surfaces ready for covalent immobilization of primary antibodies and a strong bonding between PDMS substrates and PC supports without increasing background fluorescence. In microchip EuNP immunoassay ( mu ENIA) of inactivated influenza viruses, replacing native PDMS microchips with hybrid microchips allowed the achievement of a 6-fold increase in signal-to-background ratio, a 12-fold and a 6-fold decreases in limit-of-detection (LOD) in influenza A and B tests respectively. Using influenza A samples with known titers, the LOD of influenza mu ENIA on hybrid microchips was determined to be ~104 TCID50 titer/mL and 103-104 EID50 titer/mL. A comparison test indicated that the sensitivity of influenza mu ENIA enhanced using the hybrid microchips even surpassed that of a commercial laboratory influenza ELISA test. In addition to the sensitivity improvement, assay variation was clearly reduced when hybrid microchips instead of native PDMS microchips were used in the mu ENIA tests. Finally, infectious reference viruses and nasopharyngeal swab patient specimens were successfully tested using mu ENIA on hybrid microchip platforms, demonstrating the potential of this unique microchip nanoparticle assay in clinical diagnosis of influenza. Meanwhile, the tests showed the necessity of using nucleic acid confirmatory tests to clarify ambiguous test results obtained from prototype or developed point-of-care testing devices for influenza diagnosis. JF - Biosensors and Bioelectronics AU - Liu, Jikun AU - Zhao, Jiangqin AU - Petrochenko, Peter AU - Zheng, Jiwen AU - Hewlett, Indira AD - Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, United States Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 150 EP - 155 PB - Elsevier B.V., 660 White Plains Rd. Tarrytown NY 10591-5153 United States VL - 86 SN - 0956-5663, 0956-5663 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Influenza KW - Europium nanoparticle KW - Immunoassay KW - Sol-gel coating KW - Surface functionalization KW - Lab-on-a-chip KW - Enzyme-linked immunosorbent assay KW - Fluorescence KW - Influenza A KW - Biosensors KW - Antibodies KW - Influenza virus KW - nucleic acids KW - Silica KW - Hybrids KW - microchips KW - Immunoassays KW - nanoparticles KW - Immobilization KW - polycarbonate KW - Coatings KW - W 30955:Biosensors KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827908065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=Sensitive+detection+of+influenza+viruses+with+Europium+nanoparticles+on+an+epoxy+silica+sol-gel+functionalized+polycarbonate-polydimethylsiloxane+hybrid+microchip&rft.au=Liu%2C+Jikun%3BZhao%2C+Jiangqin%3BPetrochenko%2C+Peter%3BZheng%2C+Jiwen%3BHewlett%2C+Indira&rft.aulast=Liu&rft.aufirst=Jikun&rft.date=2016-12-01&rft.volume=86&rft.issue=&rft.spage=150&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2016.06.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Fluorescence; Influenza A; Biosensors; Antibodies; Silica; nucleic acids; Hybrids; microchips; nanoparticles; Immunoassays; polycarbonate; Immobilization; Coatings; Influenza virus DO - http://dx.doi.org/10.1016/j.bios.2016.06.044 ER - TY - JOUR T1 - Literature information in PubChem: associations between PubChem records and scientific articles AN - 1827902115; PQ0003731662 AB - PubChem is an open archive consisting of a set of three primary public databases (BioAssay, Compound, and Substance). It contains information on a broad range of chemical entities, including small molecules, lipids, carbohydrates, and (chemically modified) amino acid and nucleic acid sequences (including siRNA and miRNA). Currently (as of Nov. 2015), PubChem contains more than 150 million depositor-provided chemical substance descriptions, 60 million unique chemical structures, and 225 million biological activity test results provided from over 1 million biological assay records. Many PubChem records (substances, compounds, and assays) include depositor-provided cross-references to scientific articles in PubMed. Some PubChem contributors provide bioactivity data extracted from scientific articles. Literature-derived bioactivity data complement high-throughput screening (HTS) data from the concluded NIH Molecular Libraries Program and other HTS projects. Some journals provide PubChem with information on chemicals that appear in their newly published articles, enabling concurrent publication of scientific articles in journals and associated data in public databases. In addition, PubChem links records to PubMed articles indexed with the Medical Subject Heading (MeSH) controlled vocabulary thesaurus. Literature information, both provided by depositors and derived from MeSH annotations, can be accessed using PubChem's web interfaces, enabling users to explore information available in literature related to PubChem records beyond typical web search results. [Figure not available: see fulltext.] JF - Journal of Cheminformatics AU - Kim, Sunghwan AU - Thiessen, Paul A AU - Cheng, Tiejun AU - Yu, Bo AU - Shoemaker, Benjamin A AU - Wang, Jiyao AU - Bolton, Evan E AU - Wang, Yanli AU - Bryant, Stephen H AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD, 20894, USA, kimsungh@ncbi.nlm.nih.gov Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 1 EP - 15 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 8 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Computer programs KW - Data processing KW - nucleic acids KW - siRNA KW - Informatics KW - Lipids KW - miRNA KW - high-throughput screening KW - Carbohydrates KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827902115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cheminformatics&rft.atitle=Literature+information+in+PubChem%3A+associations+between+PubChem+records+and+scientific+articles&rft.au=Kim%2C+Sunghwan%3BThiessen%2C+Paul+A%3BCheng%2C+Tiejun%3BYu%2C+Bo%3BShoemaker%2C+Benjamin+A%3BWang%2C+Jiyao%3BBolton%2C+Evan+E%3BWang%2C+Yanli%3BBryant%2C+Stephen+H&rft.aulast=Kim&rft.aufirst=Sunghwan&rft.date=2016-12-01&rft.volume=8&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cheminformatics&rft.issn=1758-2946&rft_id=info:doi/10.1186%2Fs13321-016-0142-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 31 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; nucleic acids; Data processing; siRNA; Informatics; Lipids; miRNA; high-throughput screening; Carbohydrates DO - http://dx.doi.org/10.1186/s13321-016-0142-6 ER - TY - JOUR T1 - Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure. AN - 1826715716; 27371368 AB - Furan, a rodent liver carcinogen, is a chemical contaminant found in a broad range of cooked foods. Despite a lack of conclusive evidence regarding furan genotoxicity, several reports indicate that furan induces a broad range of non-genotoxic alterations, including aberrant expression microRNAs (miRNAs). In order to clarify the role of miRNA alterations with respect to furan carcinogenicity, we investigated the expression of several cancer-related miRNAs in the livers of Fischer 344 rats treated continuously with furan. The results demonstrate that furan induced marked changes in miRNA expression, characterized by over-expression of hepatic miRNAs, miR-34a, miR-93, miR-200a, miR-200b, and miR-224, and down-regulation of miR-375. Interestingly, a majority of furan-induced miRNA changes diminished after the cessation of the furan treatment. In contrast, the expression of miR-375 steadily decreased in a time-dependent manner following furan treatment. The reduced expression of miR-375 was accompanied by cytosine DNA hypermethylation and increased lysine methylation of histone H3K9 and H3K27 at the MiR-375 gene. The significance of miR-375 inhibition with respect to the pathogenesis of furan-induced liver toxicity and carcinogenicity may be attributed to its role in the up-regulation of Yes-associated protein 1 (YAP1), which is one of the principal events in the liver carcinogenesis. The results of the present study support the hypothesis of the non-genotoxic mode of action of furan and emphasize the importance of epigenetic alterations in the mechanism of furan hepatotoxicity. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - de Conti, Aline AU - Tryndyak, Volodymyr AU - Doerge, Daniel R AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, 3900 NCTR Rd., Jefferson, AR 72079, USA. Electronic address: igor.pogribny@fda.hhs.gov. Y1 - 2016/12// PY - 2016 DA - December 2016 SP - 2 EP - 10 VL - 98 KW - Liver cancer KW - Furan KW - miR-375 KW - Epigenetic KW - miRNAs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826715716?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chirality&rft.atitle=Chiral+resolution+and+absolute+configuration+of+the+enantiomers+of+the+psychoactive+%22designer+drug%22+3%2C4-methylenedioxypyrovalerone.&rft.au=Suzuki%2C+Masaki%3BDeschamps%2C+Jeffrey+R%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Suzuki&rft.aufirst=Masaki&rft.date=2015-04-01&rft.volume=27&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Chirality&rft.issn=1520-636X&rft_id=info:doi/10.1002%2Fchir.22423 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.06.027 ER - TY - JOUR T1 - MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. AN - 1826677374; 27157613 AB - ErbB-2 amplification/overexpression accounts for an aggressive breast cancer (BC) subtype (ErbB-2-positive). Enhanced ErbB-2 expression was also found in gastric cancer (GC) and has been correlated with poor clinical outcome. The ErbB-2-targeted therapies trastuzumab (TZ), a monoclonal antibody, and lapatinib, a tyrosine kinase inhibitor, have proved highly beneficial. However, resistance to such therapies remains a major clinical challenge. We here revealed a novel mechanism underlying the antiproliferative effects of both agents in ErbB-2-positive BC and GC. TZ and lapatinib ability to block extracellular signal-regulated kinases 1/2 and phosphatidylinositol-3 kinase (PI3K)/AKT in sensitive cells inhibits c-Myc activation, which results in upregulation of miR-16. Forced expression of miR-16 inhibited in vitro proliferation in BC and GC cells, both sensitive and resistant to TZ and lapatinib, as well as in a preclinical BC model resistant to these agents. This reveals miR-16 role as tumor suppressor in ErbB-2-positive BC and GC. Using genome-wide expression studies and miRNA target prediction algorithms, we identified cyclin J and far upstream element-binding protein 1 (FUBP1) as novel miR-16 targets, which mediate miR-16 antiproliferative effects. Supporting the clinical relevance of our results, we found that high levels of miR-16 and low or null FUBP1 expression correlate with TZ response in ErbB-2-positive primary BCs. These findings highlight a potential role of miR-16 and FUBP1 as biomarkers of sensitivity to TZ therapy. Furthermore, we revealed miR-16 as an innovative therapeutic agent for TZ- and lapatinib-resistant ErbB-2-positive BC and GC. JF - Oncogene AU - Venturutti, L AU - Cordo Russo, R I AU - Rivas, M A AU - Mercogliano, M F AU - Izzo, F AU - Oakley, R H AU - Pereyra, M G AU - De Martino, M AU - Proietti, C J AU - Yankilevich, P AU - Roa, J C AU - Guzmán, P AU - Cortese, E AU - Allemand, D H AU - Huang, T H AU - Charreau, E H AU - Cidlowski, J A AU - Schillaci, R AU - Elizalde, P V AD - Laboratory of Molecular Mechanisms of Carcinogenesis, Instituto de Biología y Medicina Experimental, CONICET, Buenos Aires, Argentina. ; Department of Medicine, Weill Cornell Medicine, New York, NY, USA. ; Department of Health and Human Services, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA. ; Instituto de Investigación en Biomedicina de Buenos Aires, CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina. ; Departamento de Anatomía Patológica (BIOREN), Universidad de La Frontera, Temuco, Chile. ; Servicio de Ginecología, Hospital Aeronáutico Central, Buenos Aires, Argentina. ; Unidad de Patología Mamaria, Hospital General de Agudos 'Juan A Fernández', Buenos Aires, Argentina. ; Department of Molecular Medicine/Institute of Biotechnology, Cancer Therapy and Research Center, University of Texas, San Antonio, TX, USA. Y1 - 2016/12/01/ PY - 2016 DA - 2016 Dec 01 SP - 6189 EP - 6202 VL - 35 IS - 48 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826677374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=MiR-16+mediates+trastuzumab+and+lapatinib+response+in+ErbB-2-positive+breast+and+gastric+cancer+via+its+novel+targets+CCNJ+and+FUBP1.&rft.au=Venturutti%2C+L%3BCordo+Russo%2C+R+I%3BRivas%2C+M+A%3BMercogliano%2C+M+F%3BIzzo%2C+F%3BOakley%2C+R+H%3BPereyra%2C+M+G%3BDe+Martino%2C+M%3BProietti%2C+C+J%3BYankilevich%2C+P%3BRoa%2C+J+C%3BGuzm%C3%A1n%2C+P%3BCortese%2C+E%3BAllemand%2C+D+H%3BHuang%2C+T+H%3BCharreau%2C+E+H%3BCidlowski%2C+J+A%3BSchillaci%2C+R%3BElizalde%2C+P+V&rft.aulast=Venturutti&rft.aufirst=L&rft.date=2016-12-01&rft.volume=35&rft.issue=48&rft.spage=6189&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2016.151 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/onc.2016.151 ER - TY - JOUR T1 - Reproductive history and risk of colorectal adenocarcinoma in parous women: a Nordic population-based case-control study. AN - 1835379465; 27701386 AB - Data are conflicting regarding the role of endogenous sex hormones in colorectal carcinogenesis. In this large population-based study, we pooled data from birth and cancer registries in four Nordic countries, to evaluate the risk of colorectal adenocarcinoma in relation to women's reproductive history. We conducted a population-based case-control study among women registered in Nordic birth registries. The study included colorectal adenocarcinoma cases diagnosed in Denmark, Finland, Norway, and Sweden during 1967-2013 and up to 10 matched controls per case, in total 22 185 cases and 220 246 controls. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were derived from conditional logistic regression models. We had limited information available on possible confounders. We found no evidence for associations between colorectal adenocarcinoma and parity, age at first and last birth, and time since first and last birth. The risk estimates were also close to unity for specific cancer subsites (proximal and distal colon and rectum). As well, when the analyses were stratified on menopausal status, parity, and mother's year of birth, no indication of associations was found. In this large, Nordic population-based study, no evidence for associations was found between women's reproductive history and colorectal adenocarcinoma in parous women. JF - British journal of cancer AU - Bjørge, Tone AU - Gissler, Mika AU - Ording, Anne Gulbech AU - Engeland, Anders AU - Glimelius, Ingrid AU - Leinonen, Maarit AU - Sørensen, Henrik Toft AU - Tretli, Steinar AU - Ekbom, Anders AU - Troisi, Rebecca AU - Grotmol, Tom AD - Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. ; National Institute for Health and Welfare (THL), Helsinki, Finland. ; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. ; Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. ; Cancer Society of Finland, Finnish Cancer Registry, Helsinki, Finland. ; Cancer Registry of Norway, Oslo, Norway. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2016/11/22/ PY - 2016 DA - 2016 Nov 22 SP - 1416 EP - 1420 VL - 115 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835379465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+cancer&rft.atitle=Reproductive+history+and+risk+of+colorectal+adenocarcinoma+in+parous+women%3A+a+Nordic+population-based+case-control+study.&rft.au=Bj%C3%B8rge%2C+Tone%3BGissler%2C+Mika%3BOrding%2C+Anne+Gulbech%3BEngeland%2C+Anders%3BGlimelius%2C+Ingrid%3BLeinonen%2C+Maarit%3BS%C3%B8rensen%2C+Henrik+Toft%3BTretli%2C+Steinar%3BEkbom%2C+Anders%3BTroisi%2C+Rebecca%3BGrotmol%2C+Tom&rft.aulast=Bj%C3%B8rge&rft.aufirst=Tone&rft.date=2016-11-22&rft.volume=115&rft.issue=11&rft.spage=1416&rft.isbn=&rft.btitle=&rft.title=British+journal+of+cancer&rft.issn=1532-1827&rft_id=info:doi/10.1038%2Fbjc.2016.315 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/bjc.2016.315 ER - TY - JOUR T1 - Assessing the reliability of ecotoxicological studies: An overview of current needs and approaches. AN - 1842550464; 27869364 AB - In general, reliable studies are well designed and well performed, and enough details on study design and performance are reported to assess the study. For hazard and risk assessment in various legal frameworks, many different types of ecotoxicity studies need to be evaluated for reliability. These studies vary in study design, methodology, quality, and level of detail reported (e.g., reviews, peer-reviewed research papers, or industry-sponsored studies documented under Good Laboratory Practice [GLP] guidelines). Regulators have the responsibility to make sound and verifiable decisions and should evaluate each study for reliability in accordance with scientific principles regardless of whether they were conducted in accordance with GLP and/or standardized methods. Thus, a systematic and transparent approach is needed to evaluate studies for reliability. In this paper, 8 different methods for reliability assessment were compared using a number of attributes: categorical versus numerical scoring methods, use of exclusion and critical criteria, weighting of criteria, whether methods are tested with case studies, domain of applicability, bias toward GLP studies, incorporation of standard guidelines in the evaluation method, number of criteria used, type of criteria considered, and availability of guidance material. Finally, some considerations are given on how to choose a suitable method for assessing reliability of ecotoxicity studies. Integr Environ Assess Manag. ©2016 SETAC. © 2016 SETAC. JF - Integrated environmental assessment and management AU - Moermond, Caroline AU - Beasley, Amy AU - Breton, Roger AU - Junghans, Marion AU - Laskowski, Ryszard AU - Solomon, Keith AU - Zahner, Holly AD - Centre for Safety of Substances and Products, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. ; The Dow Chemical Company, Toxicology and Environmental Research and Consulting, Midland, Michigan, USA. ; Intrinsik, Ottawa, Ontario, Canada. ; Swiss Centre for Applied Ecotoxicology Eawag-EPFL, Dübendorf, Switzerland. ; Institute of Environmental Sciences, Jagiellonian University, Kraków, Poland. ; Centre for Toxicology, School of Environmental Science, University of Guelph, Guelph, Ontario, Canada. ; US Food and Drug Administration, Center for Veterinary Medicine, Rockville, Maryland. Y1 - 2016/11/21/ PY - 2016 DA - 2016 Nov 21 KW - Risk assessment KW - Quality evaluation KW - Literature evaluation KW - Reliability assessment KW - Hazard assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842550464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrated+environmental+assessment+and+management&rft.atitle=Assessing+the+reliability+of+ecotoxicological+studies%3A+An+overview+of+current+needs+and+approaches.&rft.au=Moermond%2C+Caroline%3BBeasley%2C+Amy%3BBreton%2C+Roger%3BJunghans%2C+Marion%3BLaskowski%2C+Ryszard%3BSolomon%2C+Keith%3BZahner%2C+Holly&rft.aulast=Moermond&rft.aufirst=Caroline&rft.date=2016-11-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Integrated+environmental+assessment+and+management&rft.issn=1551-3793&rft_id=info:doi/10.1002%2Fieam.1870 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-21 N1 - Date revised - 2017-01-31 N1 - Last updated - 2017-01-31 DO - http://dx.doi.org/10.1002/ieam.1870 ER - TY - JOUR T1 - A mechanistic investigation of thrombotic microangiopathy associated with intravenous abuse of Opana ER. AN - 1841799803; 27864296 AB - Since 2012, a number of case reports have described the occurrence of thrombotic microangiopathy (TMA) following intravenous abuse of extended release oxymorphone hydrochloride (Opana ER), an oral opioid for long-term treatment of chronic pain. Here, we present unique clinical features of three patients and investigate intravenous exposure to the tablet's inert ingredients as a possible causal mechanism. Guinea pigs were used as an animal model to understand the hematopathologic and nephrotoxic potential of the inert ingredient mixture (termed here as PEO+) which primarily contains high molecular weight polyethylene oxide (HMW PEO). Microangiopathic hemolytic anemia, thrombocytopenia and acute kidney injury were found in a group of three patients following recent injection of adulterated extended release oxymorphone tablets. Varying degrees of cardiac involvement and retinal ischemia occurred, with TMA evident on kidney biopsy. A TMA-like state also developed in guinea pigs intravenously administered PEO+. Acute tubular and glomerular renal injury was accompanied by non-heme iron deposition and hypoxia inducible factor-1 alpha upregulation in the renal cortex. Similar outcomes were observed following dosing with HMW PEO alone. Intravenous exposure to the inert ingredients in reformulated extended release oxymorphone can elicit thrombotic microangiopathy. While prescription opioid abuse shows geographic variation, all physicians should be highly inquisitive of intravenous drug abuse when presented with cases of thrombotic microangiopathy. Copyright © 2016 American Society of Hematology. JF - Blood AU - Hunt, Ryan AU - Yalamanoglu, Ayla AU - Tumlin, James AU - Schiller, Tal AU - Baek, Jin Hyen AU - Wu, Andrew AU - Fogo, Agnes B AU - Yang, Haichun AU - Wong, Edward AU - Miller, Peter AU - Buehler, Paul W AU - Kimchi-Sarfaty, Chava AD - Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, United States. ; Division of Blood Components and Devices, Office of Blood Research and Review, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, United States. ; Department of Internal Medicine, University of Tennessee College of Medicine at Chattanooga, Chattanooga, TN, United States. ; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. ; Departments of Pediatrics and Pathology, George Washington School of Medicine and Health Sciences, Washington, DC, United States. ; Dept. of Internal Medicine, Section on Hematology and Oncology; Section on Pulmonary, Critical Care, Allergy and Immunology; Department of Anesthesiology, Section on Critical Care Medicine, Wake Forest, Winston-Salem, NC, United States. ; Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, United States; chava.kimchi-sarfaty@fda.hhs.gov. Y1 - 2016/11/18/ PY - 2016 DA - 2016 Nov 18 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1841799803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=A+mechanistic+investigation+of+thrombotic+microangiopathy+associated+with+intravenous+abuse+of+Opana+ER.&rft.au=Hunt%2C+Ryan%3BYalamanoglu%2C+Ayla%3BTumlin%2C+James%3BSchiller%2C+Tal%3BBaek%2C+Jin+Hyen%3BWu%2C+Andrew%3BFogo%2C+Agnes+B%3BYang%2C+Haichun%3BWong%2C+Edward%3BMiller%2C+Peter%3BBuehler%2C+Paul+W%3BKimchi-Sarfaty%2C+Chava&rft.aulast=Hunt&rft.aufirst=Ryan&rft.date=2016-11-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=1528-0020&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Focusing on Core Patient-Reported Outcomes in Cancer Clinical Trials-Response AN - 1846407496; PQ0003881684 JF - Clinical Cancer Research AU - Kluetz, Paul G AU - Papadopoulos, Elektra J AU - Johnson, Laura Lee AU - Donoghue, Martha AU - Kwitkowski, Virginia E AU - Chen, Wen-Hung AU - Sridhara, Rajeshwari AU - Farrell, Ann T AU - Keegan, Patricia AU - Kim, Geoffrey AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, paul.kluetz@fda.hhs.gov Y1 - 2016/11/15/ PY - 2016 DA - 2016 Nov 15 SP - 5618 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 22 IS - 22 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846407496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Focusing+on+Core+Patient-Reported+Outcomes+in+Cancer+Clinical+Trials-Response&rft.au=Kluetz%2C+Paul+G%3BPapadopoulos%2C+Elektra+J%3BJohnson%2C+Laura+Lee%3BDonoghue%2C+Martha%3BKwitkowski%2C+Virginia+E%3BChen%2C+Wen-Hung%3BSridhara%2C+Rajeshwari%3BFarrell%2C+Ann+T%3BKeegan%2C+Patricia%3BKim%2C+Geoffrey%3BPazdur%2C+Richard&rft.aulast=Kluetz&rft.aufirst=Paul&rft.date=2016-11-15&rft.volume=22&rft.issue=22&rft.spage=5618&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-16-2140 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-07 DO - http://dx.doi.org/10.1158/1078-0432.CCR-16-2140 ER - TY - JOUR T1 - Magnetic resonance spectroscopic analysis of neurometabolite changes in the developing rat brain at 7T. AN - 1835688591; 27663970 AB - We utilized proton magnetic resonance spectroscopy to evaluate the metabolic profile of the hippocampus and anterior cingulate cortex of the developing rat brain from postnatal days 14-70. Measured metabolite concentrations were modeled using linear, exponential, or logarithmic functions and the time point at which the data reached plateau (i.e. when the portion of the data could be fit to horizontal line) was estimated and was interpreted as the time when the brain has reached maturity with respect to that metabolite. N-acetyl-aspartate and myo-inositol increased within the observed period. Gluthathione did not vary significantly, while taurine decreased initially and then stabilized. Phosphocreatine and total creatine had a tendency to increase towards the end of the experiment. Some differences between our data and the published literature were observed in the concentrations and dynamics of phosphocreatine, myo-inositol, and GABA in the hippocampus and creatine, GABA, glutamine, choline and N-acetyl-aspartate in the cortex. Such differences may be attributed to experimental conditions, analysis approaches and animal species. The latter is supported by differences between in-house rat colony and rats from Charles River Labs. Spectroscopy provides a valuable tool for non-invasive brain neurochemical profiling for use in developmental neurobiology research. Special attention needs to be paid to important sources of variation like animal strain and commercial source. Published by Elsevier B.V. JF - Brain research AU - Ramu, Jaivijay AU - Konak, Tetyana AU - Liachenko, Serguei AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. ; Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. Electronic address: Serguei.liachenko@fda.hhs.gov. Y1 - 2016/11/15/ PY - 2016 DA - 2016 Nov 15 SP - 114 EP - 120 VL - 1651 KW - Rat KW - Neurometabolite KW - Magnetic resonance spectroscopy KW - Developmental neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835688591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Magnetic+resonance+spectroscopic+analysis+of+neurometabolite+changes+in+the+developing+rat+brain+at+7T.&rft.au=Ramu%2C+Jaivijay%3BKonak%2C+Tetyana%3BLiachenko%2C+Serguei&rft.aulast=Ramu&rft.aufirst=Jaivijay&rft.date=2016-11-15&rft.volume=1651&rft.issue=&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2016.09.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.brainres.2016.09.028 ER - TY - JOUR T1 - In Vitro Toxicity Evaluation of Lignin-(Un)coated Cellulose Based Nanomaterials on Human A549 and THP-1 Cells. AN - 1835405437; 27709894 AB - A significant amount of research toward commercial development of cellulose based nanomaterials (CNM) is now in progress with some potential applications. Using human A549 and THP-1 cells, we evaluated the biological responses of various CNMs, made out of similar material but with functional and morphological variations. While A549 cells displayed minimal or no cytotoxic responses following exposure to CNMs, THP-1 cells were more susceptible to cytotoxicity, cellular damage and inflammatory responses. Further analysis of these biological responses evaluated using hierarchical clustering approaches was effective in discriminating (dis)-similarities of various CNMs studied and identified potential inflammatory factors contributing to cytotoxicity. No correlation between cytotoxicity and surface properties of CNMs was found. This study clearly highlights that, in addition to the source and characteristics of CNMs, cell type-specific differences in the recognition/uptake of CNMs along with their inherent capability to respond to external stimuli are crucial for assessing the toxicity of CNMs. JF - Biomacromolecules AU - Yanamala, Naveena AU - Kisin, Elena R AU - Menas, Autumn L AU - Farcas, Mariana T AU - Khaliullin, Timur O AU - Vogel, Ulla B AU - Shurin, Galina V AU - Schwegler-Berry, Diane AU - Fournier, Philip M AU - Star, Alexander AU - Shvedova, Anna A AD - Exposure Assessment Branch/NIOSH/CDC, Morgantown, West Virginia 26505, United States. ; National Research Centre for the Working Environment , Copenhagen DK-2100, Denmark. ; Department of Pathology, University of Pittsburgh Medical Center , Pittsburgh, Pennsylvania 15213, United States. ; Pathology & Physiology Research Branch/NIOSH/CDC, Morgantown, West Virginia 26505, United States. ; Department of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15213, United States. Y1 - 2016/11/14/ PY - 2016 DA - 2016 Nov 14 SP - 3464 EP - 3473 VL - 17 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835405437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomacromolecules&rft.atitle=In+Vitro+Toxicity+Evaluation+of+Lignin-%28Un%29coated+Cellulose+Based+Nanomaterials+on+Human+A549+and+THP-1+Cells.&rft.au=Yanamala%2C+Naveena%3BKisin%2C+Elena+R%3BMenas%2C+Autumn+L%3BFarcas%2C+Mariana+T%3BKhaliullin%2C+Timur+O%3BVogel%2C+Ulla+B%3BShurin%2C+Galina+V%3BSchwegler-Berry%2C+Diane%3BFournier%2C+Philip+M%3BStar%2C+Alexander%3BShvedova%2C+Anna+A&rft.aulast=Yanamala&rft.aufirst=Naveena&rft.date=2016-11-14&rft.volume=17&rft.issue=11&rft.spage=3464&rft.isbn=&rft.btitle=&rft.title=Biomacromolecules&rft.issn=1526-4602&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Myofibroblasts and lung fibrosis induced by carbon nanotube exposure. AN - 1836734631; 27814727 AB - Carbon nanotubes (CNTs) are newly developed materials with unique properties and a range of industrial and commercial applications. A rapid expansion in the production of CNT materials may increase the risk of human exposure to CNTs. Studies in rodents have shown that certain forms of CNTs are potent fibrogenic inducers in the lungs to cause interstitial, bronchial, and pleural fibrosis characterized by the excessive deposition of collagen fibers and the scarring of involved tissues. The cellular and molecular basis underlying the fibrotic response to CNT exposure remains poorly understood. Myofibroblasts are a major type of effector cells in organ fibrosis that secrete copious amounts of extracellular matrix proteins and signaling molecules to drive fibrosis. Myofibroblasts also mediate the mechano-regulation of fibrotic matrix remodeling via contraction of their stress fibers. Recent studies reveal that exposure to CNTs induces the differentiation of myofibroblasts from fibroblasts in vitro and stimulates pulmonary accumulation and activation of myofibroblasts in vivo. Moreover, mechanistic analyses provide insights into the molecular underpinnings of myofibroblast differentiation and function induced by CNTs in the lungs.In view of the apparent fibrogenic activity of CNTs and the emerging role of myofibroblasts in the development of organ fibrosis, we discuss recent findings on CNT-induced lung fibrosis with emphasis on the role of myofibroblasts in the pathologic development of lung fibrosis. Particular attention is given to the formation and activation of myofibroblasts upon CNT exposure and the possible mechanisms by which CNTs regulate the function and dynamics of myofibroblasts in the lungs. It is evident that a fundamental understanding of the myofibroblast and its function and regulation in lung fibrosis will have a major influence on the future research on the pulmonary response to nano exposure, particle and fiber-induced pneumoconiosis, and other human lung fibrosing diseases. JF - Particle and fibre toxicology AU - Dong, Jie AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV, USA. ; Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, WV, USA. qam1@cdc.gov. Y1 - 2016/11/04/ PY - 2016 DA - 2016 Nov 04 SP - 60 VL - 13 IS - 1 KW - Myofibroblast KW - Mechanism KW - Extracellular matrix KW - Carbon nanotube KW - Lung fibrosis KW - Animal model UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1836734631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Myofibroblasts+and+lung+fibrosis+induced+by+carbon+nanotube+exposure.&rft.au=Dong%2C+Jie%3BMa%2C+Qiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2016-11-04&rft.volume=13&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - TNF-α modulates genome-wide redistribution of ΔNp63α/TAp73 and NF-κB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer. AN - 1826672972; 27132513 AB - The Cancer Genome Atlas (TCGA) network study of 12 cancer types (PanCancer 12) revealed frequent mutation of TP53, and amplification and expression of related TP63 isoform ΔNp63 in squamous cancers. Further, aberrant expression of inflammatory genes and TP53/p63/p73 targets were detected in the PanCancer 12 project, reminiscent of gene programs comodulated by cREL/ΔNp63/TAp73 transcription factors we uncovered in head and neck squamous cell carcinomas (HNSCCs). However, how inflammatory gene signatures and cREL/p63/p73 targets are comodulated genome wide is unclear. Here, we examined how the inflammatory factor tumor necrosis factor-α (TNF-α) broadly modulates redistribution of cREL with ΔNp63α/TAp73 complexes and signatures genome wide in the HNSCC model UM-SCC46 using chromatin immunoprecipitation sequencing (ChIP-seq). TNF-α enhanced genome-wide co-occupancy of cREL with ΔNp63α on TP53/p63 sites, while unexpectedly promoting redistribution of TAp73 from TP53 to activator protein-1 (AP-1) sites. cREL, ΔNp63α and TAp73 binding and oligomerization on NF-κB-, TP53- or AP-1-specific sequences were independently validated by ChIP-qPCR (quantitative PCR), oligonucleotide-binding assays and analytical ultracentrifugation. Function of the binding activity was confirmed using TP53-, AP-1- and NF-κB-specific REs or p21, SERPINE1 and IL-6 promoter luciferase reporter activities. Concurrently, TNF-α regulated a broad gene network with cobinding activities for cREL, ΔNp63α and TAp73 observed upon array profiling and reverse transcription-PCR. Overlapping target gene signatures were observed in squamous cancer subsets and in inflamed skin of transgenic mice overexpressing ΔNp63α. Furthermore, multiple target genes identified in this study were linked to TP63 and TP73 activity and increased gene expression in large squamous cancer samples from PanCancer 12 TCGA by CircleMap. PARADIGM inferred pathway analysis revealed the network connection of TP63 and NF-κB complexes through an AP-1 hub, further supporting our findings. Thus, inflammatory cytokine TNF-α mediates genome-wide redistribution of the cREL/p63/p73, and AP-1 interactome, to diminish TAp73 tumor suppressor function and reciprocally activate NF-κB and AP-1 gene programs implicated in malignancy. JF - Oncogene AU - Si, H AU - Lu, H AU - Yang, X AU - Mattox, A AU - Jang, M AU - Bian, Y AU - Sano, E AU - Viadiu, H AU - Yan, B AU - Yau, C AU - Ng, S AU - Lee, S K AU - Romano, R-A AU - Davis, S AU - Walker, R L AU - Xiao, W AU - Sun, H AU - Wei, L AU - Sinha, S AU - Benz, C C AU - Stuart, J M AU - Meltzer, P S AU - Van Waes, C AU - Chen, Z AD - Tumor Biology Section, Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders, NIH, Bethesda, Maryland, USA. ; Department of Chemistry and Biochemistry, University of California, San Diego, CA, USA. ; Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Circuito Exterior, Ciudad Universitaria, Mexico City, MÉXICO. ; LKS Faculty of Medicine and School of Biomedical Sciences, LKS Faculty of Medicine and Center of Genome Sciences, The University of Hong Kong, Hong Kong, China. ; Buck Institute for Research on Aging, Novato, CA, USA. ; Department of Biomolecular Engineering, Center for Biomolecular Sciences and Engineering, University of California, Santa Cruz, Santa Cruz, CA, USA. ; Department of Biochemistry, State University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences, Buffalo, New York, USA. ; Cancer Genetics Branch, National Cancer Institute, Bethesda, Maryland, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AK, USA. ; Biodata Mining and Discovery Section, National Institute of Arthritis, Musculoskeletal and Skin Diseases, Bethesda, Maryland, USA. ; Clinical Immunology Section, National Eye Institute, NIH, Bethesda, Maryland, USA. Y1 - 2016/11/03/ PY - 2016 DA - 2016 Nov 03 SP - 5781 EP - 5794 VL - 35 IS - 44 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826672972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=TNF-%CE%B1+modulates+genome-wide+redistribution+of+%CE%94Np63%CE%B1%2FTAp73+and+NF-%CE%BAB+cREL+interactive+binding+on+TP53+and+AP-1+motifs+to+promote+an+oncogenic+gene+program+in+squamous+cancer.&rft.au=Si%2C+H%3BLu%2C+H%3BYang%2C+X%3BMattox%2C+A%3BJang%2C+M%3BBian%2C+Y%3BSano%2C+E%3BViadiu%2C+H%3BYan%2C+B%3BYau%2C+C%3BNg%2C+S%3BLee%2C+S+K%3BRomano%2C+R-A%3BDavis%2C+S%3BWalker%2C+R+L%3BXiao%2C+W%3BSun%2C+H%3BWei%2C+L%3BSinha%2C+S%3BBenz%2C+C+C%3BStuart%2C+J+M%3BMeltzer%2C+P+S%3BVan+Waes%2C+C%3BChen%2C+Z&rft.aulast=Si&rft.aufirst=H&rft.date=2016-11-03&rft.volume=35&rft.issue=44&rft.spage=5781&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2016.112 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/onc.2016.112 ER - TY - JOUR T1 - Rapid detection of bacterial endotoxins in ophthalmic viscosurgical device materials by direct analysis in real time mass spectrometry. AN - 1835524679; 27769383 AB - Bacterial endotoxins are lipopolysaccharides bound to the bacterial cell wall and released when bacteria rupture or disintegrate. Possible contamination of endotoxin in ophthalmic devices can cause a painful eye inflammation or result in toxic anterior segment syndrome after cataract surgery. Measurement of bacterial endotoxin in medical device materials is difficult since endotoxin binds with polymer matrix and some of the materials are very viscous and non-water soluble, where traditional enzyme-based Limulus amebocyte lysate (LAL) assay cannot be applied. Here we propose a rapid and high throughput ambient ionization mass spectrometric (MS) method using direct analysis in real time (DART) for the evaluation of endotoxin contamination in medical device materials. Large and structurally complex endotoxin instantaneously breaks down into low-mass characteristic fragment ions using DART and is detected by MS in both positive and negative ion modes. This method enables the identification and separation of endotoxin from medical materials with a detection limit of 0.03 ng mL-1 endotoxins in aqueous solution. Ophthalmic viscosurgical device materials including sodium hyaluronate (NaHA), non-water soluble perfluoro-n-octane (PFO) and silicone oil (SO) were spiked with different known concentrations of endotoxin and analyzed by DART MS, where the presence of endotoxin was successfully detected and featured small mass fragment ions were generated for NaHA, PFO and SO as well. Current findings showed the feasibility of measuring endotoxin contamination in medical device materials using DART-MS, which can lead to a one-step analysis of endotoxins in different matrices, avoiding any potential contamination during sample pre-treatment steps. Published by Elsevier B.V. JF - Analytica chimica acta AU - Li, Hongli AU - Hitchins, Victoria M AU - Wickramasekara, Samanthi AD - Division of Biology, Chemistry, and Materials Science, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, 20993, United States; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biomedical Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. ; Division of Biology, Chemistry, and Materials Science, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, 20993, United States. ; Division of Biology, Chemistry, and Materials Science, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, 20993, United States. Electronic address: Samanthi.Wickramasekara@fda.hhs.gov. Y1 - 2016/11/02/ PY - 2016 DA - 2016 Nov 02 SP - 98 EP - 105 VL - 943 KW - Silicone oil KW - Endotoxin KW - Sodium hyaluronate KW - Mass spectrometry KW - Direct analysis in real time KW - Perfluoro-n-octane UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835524679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+chimica+acta&rft.atitle=Rapid+detection+of+bacterial+endotoxins+in+ophthalmic+viscosurgical+device+materials+by+direct+analysis+in+real+time+mass+spectrometry.&rft.au=Li%2C+Hongli%3BHitchins%2C+Victoria+M%3BWickramasekara%2C+Samanthi&rft.aulast=Li&rft.aufirst=Hongli&rft.date=2016-11-02&rft.volume=943&rft.issue=&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Analytica+chimica+acta&rft.issn=1873-4324&rft_id=info:doi/10.1016%2Fj.aca.2016.09.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aca.2016.09.030 ER - TY - JOUR T1 - DYNAMIC RESPONSE OF CCD ARRAY SPECTRORADIOMETERS AN - 1868319859; PQ0004026973 AB - A number of factors affect the measurements by charge coupled (CCD) array spectroradiometers, including stray light, dynamic response and ambient temperature. The departure from linearity was assessed for four CCD array spectroradiometers and linearity correction calculated with standard uncertainties error estimates. A fixed irradiance source supplemented with neutral density filters was used to allow tests to cover a full range of operational conditions. The dependence of the dynamic response on well depth and integration time was investigated. One spectroradiometer exhibited an accumulated departure from linearity of -20 % near the top of the well; for others the departure from linearity was less pronounced. JF - Radiation Protection Dosimetry AU - Baczynska, Katarzyna Anna AU - Price, Luke L A AU - Khazova, Marina AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 0RQ, UK, katarzyna.baczynska@PHE.gov.uk Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 291 EP - 296 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 171 IS - 3 SN - 0144-8420, 0144-8420 KW - Environment Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868319859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=DYNAMIC+RESPONSE+OF+CCD+ARRAY+SPECTRORADIOMETERS&rft.au=Baczynska%2C+Katarzyna+Anna%3BPrice%2C+Luke+L+A%3BKhazova%2C+Marina&rft.aulast=Baczynska&rft.aufirst=Katarzyna&rft.date=2016-11-01&rft.volume=171&rft.issue=3&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncv396 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1093/rpd/ncv396 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIM® VX IN WISTAR HAN [Crl:WI (Han)] RATS AND B6C3F1/N MICE (INHALATION STUDIES) AN - 1854174767 AB - TRIM VX is a metalworking fluid used as a lubricant and coolant liquid for cleaning tools and parts during cutting, drilling, milling, and grinding. Occupational exposures to metalworking fluids, including TRIM VX, occur primarily by dermal contact and inhalation. Inhalation exposure to other metalworking fluids has been reported to cause respiratory problems and to be associated with other health effects. We conducted studies of TRIM VX in rats and mice to determine if it caused cancer or other health effects. We exposed groups of 50 male and female rats and mice to atmospheres containing aerosols of 10, 30, or 100 mg of TRIM VX per cubic meter of air. Similar groups of animals exposed to clean air in the same type of inhalation chambers served as the control groups. Animals were exposed six hours per day, five days per week for two years. Tissues from more than 40 sites were examined for every animal. The respiratory tract was the primary site of toxicity in all groups of male and female rats and mice exposed to TRIM VX. A wide spectrum of lesions (i.e., hyperplasia, inflammation, metaplasia, fibrosis) of the lung, nose, larynx, and lymph nodes was seen. The lesions were significantly increased across exposed groups of rats and mice, and many were observed at the lowest concentration tested (10 mg/m^sup 3^). In addition to these lesions, there were low occurrences of lung tumors in male and female rats and increases in the incidences of lung tumors in male and female mice exposed to the highest concentration of TRIM VX. We conclude that exposure to aerosols of TRIM VX caused tumors of the lung in male and female mice and may have caused tumors of the lung in male and female rats. TRIM VX also caused a spectrum of lesions in the respiratory tract of male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 1 EP - 13,15,17-23,25-65J,67-71,73-93,95-141,143-155,157-186 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Tumors KW - Rodents KW - Animal behavior KW - Females UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1854174767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+TRIM%C2%AE+VX+IN+WISTAR+HAN+%5BCrl%3AWI+%28Han%29%5D+RATS+AND+B6C3F1%2FN+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-11-01&rft.volume=&rft.issue=591&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Name - National Institute for Occupational Safety & Health N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2016 N1 - Document feature - References; Tables; Graphs N1 - Last updated - 2016-12-30 ER - TY - RPRT T1 - Table of contents AN - 1854174728 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1854174728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-11-01&rft.volume=&rft.issue=591&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2016 N1 - Last updated - 2016-12-30 ER - TY - RPRT T1 - FOREWORD AN - 1854174573 AB - The National Toxicology Program (NTP) is an interagency program within the Public Health Service (PHS) of the Department of Health and Human Services (HHS) and is headquartered at the National Institute of Environmental Health Sciences of the National Institutes of Health (NIEHS/NIH). JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Public health KW - Health services KW - Laboratory animals KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1854174573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-11-01&rft.volume=&rft.issue=591&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Name - Food & Drug Administration--FDA; Department of Health & Human Services N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2016 N1 - Last updated - 2016-12-30 ER - TY - JOUR T1 - Adaptive Design Practice at the Center for Devices and Radiological Health (CDRH), January 2007 to May 2013 AN - 1846421960; PQ0003863090 AB - Adaptive designs have generated great interest in the clinical trial community as a result of their versatility and efficiency. Recently, the Center for Devices and Radiological Health (CDRH) at the US Food and Drug Administration (FDA) surveyed all adaptive design applications submitted between 2007 and May 2013 for regulatory review. In this paper, we discuss the overall results and findings that emerged from an in-depth examination of the submissions. We summarize the current status of adaptive designs used in medical device studies. We also identify some of the lessons learned and common pitfalls that we encountered in our review of the designs. JF - Therapeutic Innovation & Regulatory Science AU - Yang, Xiting AU - Thompson, Laura AU - Chu, Jianxiong AU - Liu, Sherry AU - Lu, Hong AU - Zhou, Jie AU - Gomatam, Shanti AU - Tang, Rong AU - Zhao, Yu AU - Ge, Yunjiang AU - Gray, Gerry W AD - 1 .Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA, xiting.yang@fda.hhs.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 710 EP - 717 PB - Sage Publications, Inc. VL - 50 IS - 6 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - adaptive design KW - medical device KW - survey KW - FDA KW - Reviews KW - Drug development KW - Clinical trials KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846421960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Trends+in+worker+hearing+loss+by+industry+sector%2C+1981-2010&rft.au=Masterson%2C+Elizabeth+A%3BDeddens%2C+James+A%3BThemann%2C+Christa+L%3BBertke%2C+Stephen%3BCalvert%2C+Geoffrey+M&rft.aulast=Masterson&rft.aufirst=Elizabeth&rft.date=2015-04-01&rft.volume=58&rft.issue=4&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22429 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 22 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Reviews; Drug development; Clinical trials DO - http://dx.doi.org/10.1177/2168479016656027 ER - TY - JOUR T1 - Expanded Access of Investigational Drugs: The Experience of the Center of Drug Evaluation and Research Over a 10-Year Period AN - 1846420079; PQ0003863104 AB - Background: The purpose of this study was to describe the experience of the Center of Drug Evaluation and Research (CDER) with expanded access of investigational drugs. Methods: Multiple searches of CDER's document tracking system were performed to identify the number, type, and indication for all expanded access requests over the 10-year time period of January 2005 through December 2014. An additional search was performed to identify all active commercial investigational drug development programs during that time period and whether or not the clinical program was placed on hold. The two searches were then cross-referenced to identify those commercial investigational drug development programs placed on clinical hold due to serious adverse events occurring within expanded access programs. Results: CDER receives over 1000 applications for expanded access each year. The majority are for single patients, roughly evenly split between emergency and nonemergency use. The vast majority, 99.7%, are allowed to proceed. The incidence of clinical holds for all commercial investigational drug development programs is 7.9%, as compared to only 0.2% related to adverse events observed in patients receiving drug treatments under expanded access. Conclusions: The expanded access program is viewed as a success from FDA's perspective based on the large number of applications processed and allowed to proceed each year. However, the actual number of patients and their health care providers that desire drug treatments available under expanded access is not known. It is exceedingly rare for a serious adverse event under expanded access to affect the development program for that drug. JF - Therapeutic Innovation & Regulatory Science AU - Jarow, Jonathan P AU - Lemery, Steven AU - Bugin, Kevin AU - Khozin, Sean AU - Moscicki, Richard AD - 1 .Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA, jonathan.jarow@fda.hhs.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 705 EP - 709 PB - Sage Publications, Inc. VL - 50 IS - 6 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - expanded access KW - compassionate use KW - US Food and Drug Administration KW - Drug development KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846420079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Unstable+Sitting+in+the+Workplace-Are+There+Physical+Activity+Benefits%3F&rft.au=Lowe%2C+Brian+D%3BSwanson%2C+Naomi+G%3BHudock%2C+Stephen+D%3BLotz%2C+W+Gregory&rft.aulast=Lowe&rft.aufirst=Brian&rft.date=2015-04-01&rft.volume=29&rft.issue=4&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/10.4278%2Fajhp.140331-CIT-127 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 10 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Drug development; Drugs DO - http://dx.doi.org/10.1177/2168479016656030 ER - TY - JOUR T1 - Stratification, Hypothesis Testing, and Clinical Trial Simulation in Pediatric Drug Development AN - 1846413613; PQ0003863103 AB - Background: Pediatric drug development is plagued by small sample sizes, unvalidated clinical endpoints, and limited studies. Objectives: The objective of this study was to determine whether age stratification within the pediatric population could be used to (1) assess response to a pharmacologic intervention and to (2) design future trials based upon published stratified disease data using clinical trial simulation (CTS). Methods: Data available from the literature for Kawasaki disease (KD) was used in the model. Age-stratified CTS for a theoretical new drug was conducted. Results: Population-specific differences due to age might affect trial success if not taken into account. CTS predicted inflammatory indices, and inclusion cutoff significantly altered the trial outcome. Finally, altered pharmacokinetics/pharmacodynamics in varying age groups of KD patients may alter drug exposure and response. Conclusions: If assumptions regarding a pediatric disease process, such as KD, do not include age stratification with inclusion or response, then the wrong decision could result with regard to age-appropriateness or approval of a drug. JF - Therapeutic Innovation & Regulatory Science AU - McMahon, Ann W AU - Watt, Kevin AU - Wang, Jian AU - Green, Dionna AU - Tiwari, Ram AU - Burckart, Gilbert J AD - 1 .Office of Pediatric Therapeutics, Office of the Commissioner, Food and Drug Administration, Silver Spring, MD, USA, ann.mcmahon@fda.hhs.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 817 EP - 822 PB - Sage Publications, Inc. VL - 50 IS - 6 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - Kawasaki disease KW - age groups KW - modeling KW - pharmacokinetics pharmacodynamics KW - Age KW - Data processing KW - Pediatrics KW - Drug development KW - Clinical trials KW - Drugs KW - Mucocutaneous lymph node syndrome KW - Pharmacokinetics KW - Pharmacodynamics KW - Models KW - Inflammation KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846413613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Healthcare+Materials&rft.atitle=Laser+3D+Printing+with+Sub-Microscale+Resolution+of+Porous+Elastomeric+Scaffolds+for+Supporting+Human+Bone+Stem+Cells&rft.au=Petrochenko%2C+Peter+E%3BTorgersen%2C+Jan%3BGruber%2C+Peter%3BHicks%2C+Lucas+A%3BZheng%2C+Jiwen%3BKumar%2C+Girish%3BNarayan%2C+Roger+J%3BGoering%2C+Peter+L%3BLiska%2C+Robert%3BStampfl%2C+Juergen%3BOvsianikov%2C+Aleksandr&rft.aulast=Petrochenko&rft.aufirst=Peter&rft.date=2015-04-01&rft.volume=4&rft.issue=5&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Advanced+Healthcare+Materials&rft.issn=21922640&rft_id=info:doi/10.1002%2Fadhm.201400442 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 16 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Pediatrics; Drug development; Drugs; Clinical trials; Pharmacodynamics; Pharmacokinetics; Mucocutaneous lymph node syndrome; Inflammation; Models DO - http://dx.doi.org/10.1177/2168479016651661 ER - TY - JOUR T1 - An FDA Analysis of Formal Dispute Resolution in the Center for Drug Evaluation and Research: 2003 Through 2014 AN - 1846409763; PQ0003863096 AB - Scientific and/or medical disputes will inevitably arise with regard to the US Food and Drug Administration's (FDA's) decision making related to drug development, new drug review, generic drug review, and postmarketing oversight. As these disputes can involve complex judgments and issues that are scientifically and commercially important, it is critical that FDA have procedures for effective and efficient resolution. FDA regulations allow a sponsor to obtain a review of an FDA decision by submitting a request for formal dispute resolution (an appeal). FDA's Center for Drug Evaluation and Research (CDER) received 137 appeal issues for fiscal years 2003 through 2014. However, sponsors can appeal the same issue multiple times, and each is considered a unique appeal; CDER received and analyzed 173 of these unique appeals. Of these 173 unique appeals, CDER accepted 140 (81%) for review and refused to accept for review 25 (14%). Eight (5%) were withdrawn by the sponsor prior to CDER making a decision whether to accept the appeal for review. Of the 140 unique appeals accepted and reviewed, CDER granted 23 (16%) appeals and denied 117 (84%). The analysis also examines an array of aspects of the process, such as (1) reasons why CDER rejected appeals, (2) reasons why sponsors submitted appeals, (3) the types of appeals that sponsors submitted, (4) the characteristics of the sponsors that submitted appeals (eg, size, past regulatory experience, legal representation), and (5) CDER's performance in meeting user fee goals associated with dispute resolution. JF - Therapeutic Innovation & Regulatory Science AU - Sharma, Khushboo AU - Harrington, Afi AU - Worrell, Sallamar AU - Bertha, Amy AD - 1 .Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA, Khushboo.Sharma@fda.hhs.gov Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 697 EP - 704 PB - Sage Publications, Inc. VL - 50 IS - 6 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - appeal KW - 30-day goal KW - formal dispute resolution KW - appeal issues KW - FDA deciding official KW - Decision making KW - Reviews KW - Drug development KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846409763?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+Innovation+%26+Regulatory+Science&rft.atitle=An+FDA+Analysis+of+Formal+Dispute+Resolution+in+the+Center+for+Drug+Evaluation+and+Research%3A+2003+Through+2014&rft.au=Sharma%2C+Khushboo%3BHarrington%2C+Afi%3BWorrell%2C+Sallamar%3BBertha%2C+Amy&rft.aulast=Sharma&rft.aufirst=Khushboo&rft.date=2016-11-01&rft.volume=50&rft.issue=6&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Therapeutic+Innovation+%26+Regulatory+Science&rft.issn=21684790&rft_id=info:doi/10.1177%2F2168479016651297 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Number of references - 9 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Decision making; Reviews; Drug development DO - http://dx.doi.org/10.1177/2168479016651297 ER - TY - JOUR T1 - Flavoured non-cigarette tobacco product use among US adults: 2013-2014 AN - 1846396774; PQ0003890692 AB - IntroductionLimited data exist on flavoured non-cigarette tobacco product (NCTP) use among US adults.MethodsData from the 2013 to 2014 National Adult Tobacco Survey (N=75233), a landline and cellular telephone survey of US adults aged greater than or equal to 18, were assessed to estimate past 30-day NCTP use, flavoured NCTP use and flavour types using bivariate analyses.ResultsDuring 2013-2014, 14.4% of US adults were past 30-day NCTP users. Nationally, an estimated 10.2 million e-cigarette users (68.2%), 6.1 million hookah users (82.3%), 4.1 million cigar smokers (36.2%) and 4.0 million smokeless tobacco users (50.6%) used flavoured products in the past 30days. The most prevalent flavours reported were menthol/mint (76.9%) for smokeless tobacco; fruit (74.0%) for hookah; fruit (52.4%), candy/chocolate/other sweet flavours (22.0%) and alcohol (14.5%) for cigars/cigarillos/filtered little cigars; fruit (44.9%), menthol/mint (43.9%) and candy/chocolate/other sweet flavours (25.7%) for e-cigarettes and fruit (56.6%), candy/chocolate/other sweet flavours (26.5%) and menthol/mint (24.8%) for pipes. Except for hookah and pipes, past 30-day flavoured product use was highest among 18-24-year olds. By cigarette smoking, never smoking e-cigarette users (84.8%) were more likely to report flavoured e-cigarette use, followed by recent former smokers (78.1%), long-term former smokers (70.4%) and current smokers (63.2%).ConclusionsFlavoured NCTP use is prominent among US adult tobacco users, particularly among e-cigarette, hookah and cigar users. Flavoured product use, especially fruit and sweet-flavoured products, was higher among younger adults. It is important for tobacco prevention and control strategies to address all forms of tobacco use, including flavoured tobacco products. JF - Tobacco Control AU - Bonhomme, Michele G AU - Holder-Hayes, Enver AU - Ambrose, Bridget K AU - Tworek, Cindy AU - Feirman, Shari P AU - King, Brian A AU - Apelberg, Benjamin J AD - Food and Drug Administration, Center for Tobacco Products, Office of Science, , Silver Spring, Maryland, USA Y1 - 2016/11// PY - 2016 DA - November 2016 SP - ii4 EP - ii13 PB - BMJ Publishing Group Ltd. VL - 25 IS - Suppl 2 SN - 0964-4563, 0964-4563 KW - Toxicology Abstracts KW - Non-cigarette tobacco products KW - Surveillance and monitoring KW - Priority/special populations KW - Disparities KW - Electronic nicotine delivery devices KW - Fruits KW - Flavor KW - Sweet taste KW - Data processing KW - Cigarette smoking KW - Tobacco KW - alcohols KW - Chocolate KW - Cellular telephones KW - Menthol KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846396774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+Control&rft.atitle=Flavoured+non-cigarette+tobacco+product+use+among+US+adults%3A+2013-2014&rft.au=Bonhomme%2C+Michele+G%3BHolder-Hayes%2C+Enver%3BAmbrose%2C+Bridget+K%3BTworek%2C+Cindy%3BFeirman%2C+Shari+P%3BKing%2C+Brian+A%3BApelberg%2C+Benjamin+J&rft.aulast=Bonhomme&rft.aufirst=Michele&rft.date=2016-11-01&rft.volume=25&rft.issue=Suppl+2&rft.spage=ii4&rft.isbn=&rft.btitle=&rft.title=Tobacco+Control&rft.issn=09644563&rft_id=info:doi/10.1136%2Ftobaccocontrol-2016-053373 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Fruits; Sweet taste; Flavor; Data processing; Cigarette smoking; alcohols; Tobacco; Chocolate; Cellular telephones; Menthol DO - http://dx.doi.org/10.1136/tobaccocontrol-2016-053373 ER - TY - JOUR T1 - Development and validation of an assessment tool for a national young worker curriculum AN - 1837326346; PQ0003760106 AB - Background An online, multiple-choice assessment was developed and validated for YouthWork-Talking Safety a NIOSH curriculum that equips middle and high school students with foundational workplace safety and health knowledge and skills. Methods Classical Test Theory was used for the test development and validation; the Jaeger method was used for cut score determination. A total of 118 multiple-choice items were developed to measure the acquisition of knowledge and skills taught through the NIOSH curriculum. Pilot testing was conducted with 192 8-12th grade students and a cut score was determined. Results The mean score for all test-takers on the Talking Safety assessment was 80.9%; total test reliability measured using an Alpha/KR20 statistic was 0.93. A minimum passing (cut) score of 74% was established. Conclusions The assessment provides an objective measure of students' acquisition of the foundational workplace safety and health competencies taught through the Talking Safety curriculum. Am. J. Ind. Med. 59:969-978, 2016. JF - American Journal of Industrial Medicine AU - Guerin, Rebecca J AU - Okun, Andrea H AU - Kelley, Patricia AD - National Institute for Occupational Safety and Health, U.S. Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 969 EP - 978 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 11 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Safety KW - Occupational safety KW - Adolescents KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837326346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Development+and+validation+of+an+assessment+tool+for+a+national+young+worker+curriculum&rft.au=Guerin%2C+Rebecca+J%3BOkun%2C+Andrea+H%3BKelley%2C+Patricia&rft.aulast=Guerin&rft.aufirst=Rebecca&rft.date=2016-11-01&rft.volume=59&rft.issue=11&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22610 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-11-23 N1 - SubjectsTermNotLitGenreText - Occupational safety; Safety; Adolescents DO - http://dx.doi.org/10.1002/ajim.22610 ER - TY - JOUR T1 - Outcomes of on-site antiretroviral therapy provision in a South African correctional facility AN - 1837311451; PQ0003812311 AB - We evaluated a novel on-site antiretroviral therapy (ART) programme in a South African correctional facility using routinely collected programme data, from a retrospective cohort of adult inmates starting ART between 03/2007 and 03/2009 followed-up to 09/2009. We report (1) mortality (using survival analysis); (2) retention in the programme (to 09/2009); and (3) virological suppression at six and 12 months (6 months (95% confidence interval 1.1-7.5)/100 person-years; p <0.001. At 09/2009, 35.6% (144/404) remained in the correctional facility, with 94.4% (136/144) retained in the programme; 38.4% (155/404) were released; and 20.0% (81/404) transferred to another facility. ART-naive patients in care six and 12 months after ART initiation, 94.7% (124/131) and 92.5% (74/80) were virologically suppressed, respectively. High early mortality warrants the early identification and management of HIV-positive inmates. The high mobility of inmates necessitates systems for facilitating continuity of care. Good virological responses and retention supports decentralising HIV care to correctional facilities. JF - International Journal of STD & AIDS AU - Telisinghe, Lilanganee AU - Hippner, Piotr AU - Churchyard, Gavin J AU - Gresak, Gillian AU - Grant, Alison D AU - Charalambous, Salome AU - Fielding, Katherine L AD - 1 .The Aurum Institute, Johannesburg, South Africa, lily.telisinghe@phe.gov.uk Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1153 EP - 1161 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 United States VL - 27 IS - 13 SN - 0956-4624, 0956-4624 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - HIV KW - AIDS KW - treatment KW - prisoners KW - correctional facilities KW - inmates KW - antiretroviral therapy KW - Prisons KW - Mortality KW - Acquired immune deficiency syndrome KW - Age KW - Data processing KW - Mobility KW - Retroviridae KW - Survival KW - Antiretroviral agents KW - CD4 antigen KW - Lentivirus KW - Sexually transmitted diseases KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837311451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=Outcomes+of+on-site+antiretroviral+therapy+provision+in+a+South+African+correctional+facility&rft.au=Telisinghe%2C+Lilanganee%3BHippner%2C+Piotr%3BChurchyard%2C+Gavin+J%3BGresak%2C+Gillian%3BGrant%2C+Alison+D%3BCharalambous%2C+Salome%3BFielding%2C+Katherine+L&rft.aulast=Telisinghe&rft.aufirst=Lilanganee&rft.date=2016-11-01&rft.volume=27&rft.issue=13&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/10.1177%2F0956462415584467 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 65 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mortality; Age; CD4 antigen; Data processing; Mobility; antiretroviral therapy; Prisons; Acquired immune deficiency syndrome; Survival; Antiretroviral agents; Sexually transmitted diseases; Lentivirus; Retroviridae DO - http://dx.doi.org/10.1177/0956462415584467 ER - TY - JOUR T1 - Exposure Matching for Extrapolation of Efficacy in Pediatric Drug Development AN - 1837306117; PQ0003734495 AB - During drug development, matching adult systemic exposures of drugs is a common approach for dose selection in pediatric patients when efficacy is partially or fully extrapolated. This is a systematic review of approaches used for matching adult systemic exposures as the basis for dose selection in pediatric trials submitted to the US Food and Drug Administration (FDA) between 1998 and 2012. The trial design of pediatric pharmacokinetic (PK) studies and the pediatric and adult systemic exposure data were obtained from FDA publicly available databases containing reviews of pediatric trials. Exposure-matching approaches that were used as the basis for pediatric dose selection were reviewed. The PK data from the adult and pediatric populations were used to quantify exposure agreement between the 2 patient populations. The main measures were the pediatric PK studies' trial design elements and drug systemic exposures (adult and pediatric). There were 31 products (86 trials) with full or partial extrapolation of efficacy with an available PK assessment. Pediatric exposures had a range of mean C sub(max) and AUC ratios (pediatric/adult) of 0.63 to 4.19 and 0.36 to 3.60, respectively. Seven of the 86 trials (8.1%) had a predefined acceptance boundary used to match adult exposures. The key PK parameter was consistently predefined for antiviral and anti-infective products. Approaches to match exposure in children and adults varied across products. A consistent approach for systemic exposure matching and evaluating pediatric PK studies is needed to guide future pediatric trials. JF - Journal of Clinical Pharmacology AU - Mulugeta, Yeruk AU - Barrett, Jeffrey S AU - Nelson, Robert AU - Eshete, Abel Tilahun AU - Mushtaq, Alvina AU - Yao, Lynne AU - Glasgow, Nicole AU - Mulberg, Andrew E AU - Gonzalez, Daniel AU - Green, Dionna AU - Florian, Jeffry AU - Krudys, Kevin AU - Seo, Shirley AU - Kim, Insook AU - Chilukuri, Dakshina AU - Burckart, Gilbert J AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1326 EP - 1334 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 56 IS - 11 SN - 0091-2700, 0091-2700 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Data processing KW - Antiviral agents KW - Pediatrics KW - Boundaries KW - Drug development KW - Children KW - Clinical trials KW - Pharmacokinetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837306117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Exposure+Matching+for+Extrapolation+of+Efficacy+in+Pediatric+Drug+Development&rft.au=Mulugeta%2C+Yeruk%3BBarrett%2C+Jeffrey+S%3BNelson%2C+Robert%3BEshete%2C+Abel+Tilahun%3BMushtaq%2C+Alvina%3BYao%2C+Lynne%3BGlasgow%2C+Nicole%3BMulberg%2C+Andrew+E%3BGonzalez%2C+Daniel%3BGreen%2C+Dionna%3BFlorian%2C+Jeffry%3BKrudys%2C+Kevin%3BSeo%2C+Shirley%3BKim%2C+Insook%3BChilukuri%2C+Dakshina%3BBurckart%2C+Gilbert+J&rft.aulast=Mulugeta&rft.aufirst=Yeruk&rft.date=2016-11-01&rft.volume=56&rft.issue=11&rft.spage=1326&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/10.1002%2Fjcph.744 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Antiviral agents; Pediatrics; Boundaries; Drug development; Children; Clinical trials; Pharmacokinetics DO - http://dx.doi.org/10.1002/jcph.744 ER - TY - JOUR T1 - Shiftwork and decline in endothelial function among police officers AN - 1837306076; PQ0003760107 AB - Background Our objective was to assess the influence of shiftwork on change in endothelial function. Methods This longitudinal study was conducted in 188 police officers (78.2% men). Shiftwork status (day, afternoon, night) was assessed objectively using daily Buffalo, NY payroll work history records. Brachial artery flow-mediated dilation (FMD) was assessed using ultrasound. Mean change in FMD% between 2004-2009 and 2010-2015 was compared across shiftwork using analysis of variance/covariance. Results Overall, mean FMD% decreased from 5.74 plus or minus 2.83 to 3.88 plus or minus 2.11 over an average of 7 years among all officers; P<0.0001. Effect modification by gender was significant. Among men (but not women), those who worked day shifts had a smaller mean ( plus or minus SE) decrease in FMD% (-0.89 plus or minus 0.35) compared with those who worked the afternoon (-2.69 plus or minus 0.39; P=0.001) or night shifts (-2.31 plus or minus 0.45; P=0.020) after risk factor adjustment. Conclusions Larger declines in endothelial function were observed among men who worked afternoon or night shifts. Further investigation is warranted. Am. J. Ind. Med. 59:1001-1008, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA JF - American Journal of Industrial Medicine AU - Charles, Luenda E AU - Zhao, Songzhu AU - Fekedulegn, Desta AU - Violanti, John M AU - Andrew, Michael E AU - Burchfiel, Cecil M AD - Health Effects Laboratory Division, Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1001 EP - 1008 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 11 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Longitudinal studies KW - Shift work KW - Historical account KW - USA KW - Risk factors KW - Gender KW - Police KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837306076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Shiftwork+and+decline+in+endothelial+function+among+police+officers&rft.au=Charles%2C+Luenda+E%3BZhao%2C+Songzhu%3BFekedulegn%2C+Desta%3BViolanti%2C+John+M%3BAndrew%2C+Michael+E%3BBurchfiel%2C+Cecil+M&rft.aulast=Charles&rft.aufirst=Luenda&rft.date=2016-11-01&rft.volume=59&rft.issue=11&rft.spage=1001&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22611 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-11-23 N1 - SubjectsTermNotLitGenreText - Longitudinal studies; Historical account; Shift work; Risk factors; Gender; Police; USA DO - http://dx.doi.org/10.1002/ajim.22611 ER - TY - JOUR T1 - Mortality of lead smelter workers: A follow-up study with exposure assessment AN - 1837301860; PQ0003760110 AB - Background Lead exposure has been linked to impaired renal function and kidney failure. High lead exposures have been associated with increased mortality from certain cancers, hypertension, cardiovascular disease, and amyotrophic lateral sclerosis (ALS). Methods We extended vital status follow-up on a cohort of 1,990 lead smelter workers by 25 years and computed standardized mortality ratios and rate ratios (RR) stratified by cumulative lead exposure. Results The update added 13,823 person-years at risk and 721 deaths. Increased risk of mortality was observed for the a priori outcomes of lung cancer, cardiovascular disease (including cerebrovascular disease), chronic kidney disease, and ALS. However, of these outcomes, only cardiovascular, cerebrovascular, and chronic kidney diseases were associated with a positive exposure-response in RR analyses. Conclusions This study reaffirms the association of lead exposure with cardiovascular and kidney diseases; however, increased mortality observed for certain cancers is not likely to be due to lead exposure. Am. J. Ind. Med. 59:979-986, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Bertke, Stephen J AU - Lehman, Everett J AU - Wurzelbacher, Steven J AU - Hein, Misty J AD - Division of Surveillance, Hazard Evaluations, and Field Studies, Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 979 EP - 986 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 11 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Lead KW - Renal function KW - Dose-response effects KW - Occupational exposure KW - Lung cancer KW - Mortality KW - Cerebrovascular diseases KW - Kidney diseases KW - Renal failure KW - Smelters KW - Cancer KW - Health risks KW - USA KW - Amyotrophic lateral sclerosis KW - Standards KW - Mining KW - Cardiovascular diseases KW - Hypertension KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837301860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+of+lead+smelter+workers%3A+A+follow-up+study+with+exposure+assessment&rft.au=Bertke%2C+Stephen+J%3BLehman%2C+Everett+J%3BWurzelbacher%2C+Steven+J%3BHein%2C+Misty+J&rft.aulast=Bertke&rft.aufirst=Stephen&rft.date=2016-11-01&rft.volume=59&rft.issue=11&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mortality; Cerebrovascular diseases; Kidney diseases; Renal failure; Smelters; Lead; Amyotrophic lateral sclerosis; Renal function; Dose-response effects; Cardiovascular diseases; Occupational exposure; Hypertension; Lung cancer; Risk assessment; Cancer; Health risks; Standards; Mining; USA DO - http://dx.doi.org/10.1002/ajim.22618 ER - TY - JOUR T1 - Secondhand smoke in the operating room? Precautionary practices lacking for surgical smoke AN - 1837301253; PQ0003760109 AB - Background Consensus organizations, government bodies, and healthcare organization guidelines recommend that surgical smoke be evacuated at the source by local exhaust ventilation (LEV) (i.e., smoke evacuators or wall suctions with inline filters). Methods Data are from NIOSH's Health and Safety Practices Survey of Healthcare Workers module on precautionary practices for surgical smoke. Results Four thousand five hundred thirty-three survey respondents reported exposure to surgical smoke: 4,500 during electrosurgery; 1,392 during laser surgery procedures. Respondents were mainly nurses (56%) and anesthesiologists (21%). Only 14% of those exposed during electrosurgery reported LEV was always used during these procedures, while 47% reported use during laser surgery. Those reporting LEV was always used were also more likely to report training and employer standard procedures addressing the hazards of surgical smoke. Few respondents reported use of respiratory protection. Conclusions Study findings can be used to raise awareness of the marginal use of exposure controls and impediments for their use. Am. J. Ind. Med. 59:1020-1031, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA JF - American Journal of Industrial Medicine AU - Steege, Andrea L AU - Boiano, James M AU - Sweeney, Marie H AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1020 EP - 1031 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 11 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Ventilation KW - Training KW - Guidelines KW - Safety KW - Medical personnel KW - Smoke KW - Filters KW - USA KW - Passive smoking KW - Health care KW - Surgery KW - Nursing KW - Lasers KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837301253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Secondhand+smoke+in+the+operating+room%3F+Precautionary+practices+lacking+for+surgical+smoke&rft.au=Steege%2C+Andrea+L%3BBoiano%2C+James+M%3BSweeney%2C+Marie+H&rft.aulast=Steege&rft.aufirst=Andrea&rft.date=2016-11-01&rft.volume=59&rft.issue=11&rft.spage=1020&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22614 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-11-23 N1 - SubjectsTermNotLitGenreText - Filters; Smoke; Passive smoking; Ventilation; Health care; Training; Nursing; Surgery; Safety; Guidelines; Lasers; Medical personnel; USA DO - http://dx.doi.org/10.1002/ajim.22614 ER - TY - JOUR T1 - Absolute Measurement of Cardiac Injury-Induced microRNAs in Biofluids across Multiple Test Sites. AN - 1835684828; 27605421 AB - Extracellular microRNAs (miRNAs) represent a promising new source of toxicity biomarkers that are sensitive indicators of site of tissue injury. In order to establish reliable approaches for use in biomarker validation studies, the HESI technical committee on genomics initiated a multi-site study to assess sources of variance associated with quantitating levels of cardiac injury induced miRNAs in biofluids using RT-qPCR. Samples were generated at a central site using a model of acute cardiac injury induced in male Wistar rats by 0.5 mg/kg isoproterenol. Biofluid samples were sent to 11 sites for measurement of 3 cardiac enriched miRNAs (miR-1-3p, miR-208a-3p, and miR-499-5p) and 1 miRNA abundant in blood (miR-16-5p) or urine (miR-192-5p) by absolute quantification using calibration curves of synthetic miRNAs. The samples included serum and plasma prepared from blood collected at 4 h, urine collected from 6 to 24 h, and plasma prepared from blood collected at 24 h post subcutaneous injection. A 3 parameter logistic model was utilized to fit the calibration curve data and estimate levels of miRNAs in biofluid samples by inverse prediction. Most sites observed increased circulating levels of miR-1-3p and miR-208a-3p at 4 and 24 h after isoproterenol treatment, with no difference seen between serum and plasma. The biological differences in miRNA levels and sample type dominated as sources of variance, along with outlying performance by a few sites. The standard protocol established in this study was successfully implemented across multiple sites and provides a benchmark method for further improvements in quantitative assays for circulating miRNAs. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Thompson, Karol L AU - Boitier, Eric AU - Chen, Tao AU - Couttet, Philippe AU - Ellinger-Ziegelbauer, Heidrun AU - Goetschy, Manuela AU - Guillemain, Gregory AU - Kanki, Masayuki AU - Kelsall, Janet AU - Mariet, Claire AU - de La Moureyre-Spire, Catherine AU - Mouritzen, Peter AU - Nassirpour, Rounak AU - O'Lone, Raegan AU - Pine, P Scott AU - Rosenzweig, Barry A AU - Sharapova, Tatiana AU - Smith, Aaron AU - Uchiyama, Hidefumi AU - Yan, Jian AU - Yuen, Peter S AU - Wolfinger, Russ AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993. ; Sanofi R&D, Disposition Safety and Animal Research, Vitry-Sur-Seine, France. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arizona 72079. ; Novartis Pharma AG, Basel, CH 4057, Switzerland. ; Toxicology, Bayer Pharma, Wuppertal, AG 42096, Germany. ; Astellas Pharma Inc, Osaka 532-8514, Japan. ; AstraZeneca Ltd, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. ; Institut De Recherches Servier, 78290 Croissy Sur Seine, France. ; Exiqon, Vedbaek DK-2950, Denmark. ; Pfizer, Andover, Massachusetts 01810. ; ILSI Health and Environmental Sciences Institute, Washington, DC 20005 Rolone@hesiglobal.org. ; National Institute of Standards and Technology, Stanford, California 94305. ; AbbVie, Abbott Park, Illinois 60064. ; Eli Lilly, Indianapolis, Indiana 46285. ; Takeda Pharmaceutical Co Ltd, Fujisawa, Kanagawa 251-8555, Japan. ; NIH/NIDDK, Bethesda, Maryland 20892. ; SAS Institute Inc, Cary, North Carolina 27513. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 115 EP - 125 VL - 154 IS - 1 KW - biomarker KW - variance KW - microRNA KW - interlaboratory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835684828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Absolute+Measurement+of+Cardiac+Injury-Induced+microRNAs+in+Biofluids+across+Multiple+Test+Sites.&rft.au=Thompson%2C+Karol+L%3BBoitier%2C+Eric%3BChen%2C+Tao%3BCouttet%2C+Philippe%3BEllinger-Ziegelbauer%2C+Heidrun%3BGoetschy%2C+Manuela%3BGuillemain%2C+Gregory%3BKanki%2C+Masayuki%3BKelsall%2C+Janet%3BMariet%2C+Claire%3Bde+La+Moureyre-Spire%2C+Catherine%3BMouritzen%2C+Peter%3BNassirpour%2C+Rounak%3BO%27Lone%2C+Raegan%3BPine%2C+P+Scott%3BRosenzweig%2C+Barry+A%3BSharapova%2C+Tatiana%3BSmith%2C+Aaron%3BUchiyama%2C+Hidefumi%3BYan%2C+Jian%3BYuen%2C+Peter+S%3BWolfinger%2C+Russ&rft.aulast=Thompson&rft.aufirst=Karol&rft.date=2016-11-01&rft.volume=154&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - County-Level Vulnerability Assessment for Rapid Dissemination of HIV or HCV Infections Among Persons Who Inject Drugs, United States. AN - 1835506163; 27763996 AB - A recent HIV outbreak in a rural network of persons who inject drugs (PWID) underscored the intersection of the expanding epidemics of opioid abuse, unsterile injection drug use (IDU), and associated increases in hepatitis C virus (HCV) infections. We sought to identify US communities potentially vulnerable to rapid spread of HIV, if introduced, and new or continuing high rates of HCV infections among PWID. We conducted a multistep analysis to identify indicator variables highly associated with IDU. We then used these indicator values to calculate vulnerability scores for each county to identify which were most vulnerable. We used confirmed cases of acute HCV infection reported to the National Notifiable Disease Surveillance System, 2012-2013, as a proxy outcome for IDU, and 15 county-level indicators available nationally in Poisson regression models to identify indicators associated with higher county acute HCV infection rates. Using these indicators, we calculated composite index scores to rank each county's vulnerability. A parsimonious set of 6 indicators were associated with acute HCV infection rates (proxy for IDU): drug-overdose deaths, prescription opioid sales, per capita income, white, non-Hispanic race/ethnicity, unemployment, and buprenorphine prescribing potential by waiver. Based on these indicators, we identified 220 counties in 26 states within the 95th percentile of most vulnerable. Our analysis highlights US counties potentially vulnerable to HIV and HCV infections among PWID in the context of the national opioid epidemic. State and local health departments will need to further explore vulnerability and target interventions to prevent transmission. JF - Journal of acquired immune deficiency syndromes (1999) AU - Van Handel, Michelle M AU - Rose, Charles E AU - Hallisey, Elaine J AU - Kolling, Jessica L AU - Zibbell, Jon E AU - Lewis, Brian AU - Bohm, Michele K AU - Jones, Christopher M AU - Flanagan, Barry E AU - Siddiqi, Azfar-E-Alam AU - Iqbal, Kashif AU - Dent, Andrew L AU - Mermin, Jonathan H AU - McCray, Eugene AU - Ward, John W AU - Brooks, John T AD - *Division of HIV/AIDS Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA;†Geospatial Research, Analysis and Services Program, Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA;‡DRT Strategies With the Geospatial Research, Analysis and Services Program, Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA;§Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA;‖HP Enterprise Services With the Geospatial Research, Analysis and Services Program, Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA;¶Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA;#Division of Science Policy, Office of the Assistant Secretary for Planning and Evaluation, US Department of Health and Human Services, Washington, DC; and**National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA. Y1 - 2016/11/01/ PY - 2016 DA - 2016 Nov 01 SP - 323 EP - 331 VL - 73 IS - 3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835506163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=County-Level+Vulnerability+Assessment+for+Rapid+Dissemination+of+HIV+or+HCV+Infections+Among+Persons+Who+Inject+Drugs%2C+United+States.&rft.au=Van+Handel%2C+Michelle+M%3BRose%2C+Charles+E%3BHallisey%2C+Elaine+J%3BKolling%2C+Jessica+L%3BZibbell%2C+Jon+E%3BLewis%2C+Brian%3BBohm%2C+Michele+K%3BJones%2C+Christopher+M%3BFlanagan%2C+Barry+E%3BSiddiqi%2C+Azfar-E-Alam%3BIqbal%2C+Kashif%3BDent%2C+Andrew+L%3BMermin%2C+Jonathan+H%3BMcCray%2C+Eugene%3BWard%2C+John+W%3BBrooks%2C+John+T&rft.aulast=Van+Handel&rft.aufirst=Michelle&rft.date=2016-11-01&rft.volume=73&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=1944-7884&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - An FDA oncology analysis of immune activating products and first-in-human dose selection. AN - 1835434366; 27743776 AB - As sub-therapeutic doses are not medically justifiable in patients with cancer, we retrospectively analyzed data on immune activating products, to assess approaches used in first-in-human (FIH) dose selection, the utility of animal toxicology studies in dose selection, and the length of time to complete FIH trials. The information collected included pharmacology and toxicology data, FIH dose and rationale, and dose-finding trial design. We used the principles of the Hill equation to estimate the FIH doses for antibodies and compared them to the doses administered to patients with acceptable toxicities. For approximately half the antibodies (44%) examined, the FIH doses were at least a hundred-fold lower than the doses safely administered to patients, indicating optimization of FIH dose selection and/or optimization of dose-finding trial design is needed to minimize patient exposure to sub-therapeutic doses. However, selection of the FIH dose for antibodies based on animal toxicology studies using 1/6th the HNSTD or 1/10th the NOAEL resulted in human doses that were unsafe for several antibodies examined. We also concluded that antibodies with Fc-modifications for increased effector function may be less tolerated, resulting in toxicities at lower doses than those without such modifications. There was insufficient information to evaluate CD3 bispecific products. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Saber, Haleh AU - Gudi, Ramadevi AU - Manning, Michael AU - Wearne, Emily AU - Leighton, John K AD - US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Hematology and Oncology Products, 10903 New Hampshire Ave, Silver Spring, MD 20903, United States. Electronic address: haleh.saber@fda.hhs.gov. ; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Hematology and Oncology Products, 10903 New Hampshire Ave, Silver Spring, MD 20903, United States. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 448 EP - 456 VL - 81 KW - MABEL KW - Immune oncology KW - First-in-human dose UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835434366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=An+FDA+oncology+analysis+of+immune+activating+products+and+first-in-human+dose+selection.&rft.au=Saber%2C+Haleh%3BGudi%2C+Ramadevi%3BManning%2C+Michael%3BWearne%2C+Emily%3BLeighton%2C+John+K&rft.aulast=Saber&rft.aufirst=Haleh&rft.date=2016-11-01&rft.volume=81&rft.issue=&rft.spage=448&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.10.002 ER - TY - JOUR T1 - Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice. AN - 1835384955; 27644598 AB - Sex is a risk factor for development of cardiotoxicity, induced by the anti-cancer drug, doxorubicin (DOX), in humans. To explore potential mechanisms underlying differential susceptibility to DOX between sexes, 8-week old male and female B6C3F1 mice were dosed with 3mg/kg body weight DOX or an equivalent volume of saline via tail vein once a week for 6, 7, 8, and 9 consecutive weeks, resulting in 18, 21, 24, and 27mg/kg cumulative DOX doses, respectively. At necropsy, one week after each consecutive final dose, the extent of myocardial injury was greater in male mice compared to females as indicated by higher plasma concentrations of cardiac troponin T at all cumulative DOX doses with statistically significant differences between sexes at the 21 and 24mg/kg cumulative doses. A greater susceptibility to DOX in male mice was further confirmed by the presence of cytoplasmic vacuolization in cardiomyocytes, with left atrium being more vulnerable to DOX cardiotoxicity. The number of TUNEL-positive cardiomyocytes was mostly higher in DOX-treated male mice compared to female counterparts, showing a statistically significant sex-related difference only in left atrium at 21mg/kg cumulative dose. DOX-treated male mice also had an increased number of γ-H2A.X-positive (measure of DNA double-strand breaks) cardiomyocytes compared to female counterparts with a significant sex effect in the ventricle at 27mg/kg cumulative dose and right atrium at 21 and 27mg/kg cumulative doses. This newly established mouse model provides a means to identify biomarkers and access potential mechanisms underlying sex-related differences in DOX-induced cardiotoxicity. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Jenkins, G Ronald AU - Lee, Taewon AU - Moland, Carrie L AU - Vijay, Vikrant AU - Herman, Eugene H AU - Lewis, Sherry M AU - Davis, Kelly J AU - Muskhelishvili, Levan AU - Kerr, Susan AU - Fuscoe, James C AU - Desai, Varsha G AD - Personalized Medicine Branch, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; Department of Mathematics, Korea University, Sejong, Republic of Korea. ; Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, The National Cancer Institute, Rockville, MD 20850-9734, United States. ; Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Arkansas Heart Hospital, Little Rock, AR 72211, United States. ; Personalized Medicine Branch, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: varsha.desai@fda.hhs.gov. Y1 - 2016/11/01/ PY - 2016 DA - 2016 Nov 01 SP - 159 EP - 174 VL - 310 KW - DNA damage KW - Apoptosis KW - Mouse model KW - Sex-based differences KW - Cardiotoxicity KW - Doxorubicin UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835384955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Sex-related+differential+susceptibility+to+doxorubicin-induced+cardiotoxicity+in+B6C3F1+mice.&rft.au=Jenkins%2C+G+Ronald%3BLee%2C+Taewon%3BMoland%2C+Carrie+L%3BVijay%2C+Vikrant%3BHerman%2C+Eugene+H%3BLewis%2C+Sherry+M%3BDavis%2C+Kelly+J%3BMuskhelishvili%2C+Levan%3BKerr%2C+Susan%3BFuscoe%2C+James+C%3BDesai%2C+Varsha+G&rft.aulast=Jenkins&rft.aufirst=G&rft.date=2016-11-01&rft.volume=310&rft.issue=&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.09.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.09.012 ER - TY - JOUR T1 - Response to "Comment on 'Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures'". AN - 1834999165; 27801650 JF - Environmental health perspectives AU - Parks, Christine G AU - Hoppin, Jane A AU - De Roos, Anneclaire J AU - Costenbader, Karen H AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/11/01/ PY - 2016 DA - 2016 Nov 01 SP - 1 VL - 124 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1834999165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Response+to+%22Comment+on+%27Rheumatoid+Arthritis+in+Agricultural+Health+Study+Spouses%3A+Associations+with+Pesticides+and+Other+Farm+Exposures%27%22.&rft.au=Parks%2C+Christine+G%3BHoppin%2C+Jane+A%3BDe+Roos%2C+Anneclaire+J%3BCostenbader%2C+Karen+H%3BSandler%2C+Dale+P&rft.aulast=Parks&rft.aufirst=Christine&rft.date=2016-11-01&rft.volume=124&rft.issue=11&rft.spage=A197&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-11-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Attentional bias training in girls at risk for depression AN - 1834802416 AB - Background This study examined, for the first time, whether attentional biases can be modified in adolescents at risk for depression. Methods The final sample consisted of 41 girls at familial risk for depression, who were randomly assigned to receive six sessions (864 trials) of real or sham attention bias training [Real attentional bias training (ABT) vs. Sham ABT]. Participants who received Real ABT completed a modified dot-probe task designed to train attention toward positive and away from negative facial expressions; in contrast, girls who received Sham ABT completed the standard dot-probe task. Attentional biases, self-reported mood, and psychophysiological responses to stress were measured at pre- and post-training assessments. Results As expected, girls who received Real ABT, but not those who received Sham ABT, exhibited significant increases from pre- to post-training in their attention toward happy faces and away from sad faces. Moreover, adolescents who received Real ABT were buffered against the negative outcomes experienced by adolescents who received Sham ABT. Specifically, only adolescents who received Sham ABT experienced an increase in negative mood and a pre- to post-training increase in heart rate in anticipation of the stressor. Conclusions The current findings provide the first experimental evidence that attentional biases can be modified in youth at risk for depression and further suggest that ABT modulates the heightened response to stress that is otherwise experienced by high-risk adolescents. JF - Journal of Child Psychology and Psychiatry AU - LeMoult, Joelle AU - Joormann, Jutta AU - Kircanski, Katharina AU - Gotlib, Ian H AD - Department of Psychology, Stanford University, California, CA, USA ; Department of Psychology, Yale University, New Haven, CT, USA ; Department of Health and Human Services, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA ; Department of Psychology, Stanford University, California, CA, USA Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 1326 EP - 1333 CY - Malden PB - Wiley Subscription Services, Inc. VL - 57 IS - 11 KW - Psychology KW - Bias KW - Teenagers KW - Heart rate KW - High risk KW - Psychophysiological aspects KW - Attentional bias KW - At risk KW - Facial expressions KW - Familial factors KW - Depression KW - First time KW - Adolescents KW - Girls UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1834802416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Attentional+bias+training+in+girls+at+risk+for+depression&rft.au=LeMoult%2C+Joelle%3BJoormann%2C+Jutta%3BKircanski%2C+Katharina%3BGotlib%2C+Ian+H&rft.aulast=LeMoult&rft.aufirst=Joelle&rft.date=2016-11-01&rft.volume=57&rft.issue=11&rft.spage=1326&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Psychology+and+Psychiatry&rft.issn=&rft_id=info:doi/10.1111%2Fjcpp.12587 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © 2016 Association for Child and Adolescent Mental Health. N1 - Last updated - 2017-01-26 DO - http://dx.doi.org/10.1111/jcpp.12587 ER - TY - JOUR T1 - Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F sub(1) mice AN - 1827934489; PQ0003704418 AB - The present study aimed to identify molecular markers of early stages of cardiotoxicity induced by a potent chemotherapeutic agent, doxorubicin (DOX). Male B6C3F sub(1) mice were dosed with 3mgkg super(-1) DOX or saline via tail vein weekly for 2, 3, 4, 6 or 8weeks (cumulative DOX doses of 6, 9, 12, 18 or 24mgkg super(-1), respectively) and euthanized a week after the last dose. Mass spectrometry-based and nuclear magnetic resonance spectrometry-based metabolic profiling were employed to identify initial biomarkers of cardiotoxicity before myocardial injury and cardiac pathology, which were not noted until after the 18 and 24mgkg super(-1) cumulative doses, respectively. After a cumulative dose of 6mgkg super(-1), 18 amino acids and four biogenic amines (acetylornithine, kynurenine, putrescine and serotonin) were significantly increased in cardiac tissue; 16 amino acids and two biogenic amines (acetylornithine and hydroxyproline) were significantly altered in plasma. In addition, 16 acylcarnitines were significantly increased in plasma and five were significantly decreased in cardiac tissue compared to saline-treated controls. Plasma lactate and succinate, involved in the Krebs cycle, were significantly altered after a cumulative dose of 6mgkg super(-1). A few metabolites remained altered at higher cumulative DOX doses, which could partly indicate a transition from injury processes at 2weeks to repair processes with additional injury happening concurrently before myocardial injury at 8weeks. These altered metabolic profiles in mouse heart and plasma during the initial stages of injury progression due to DOX treatment may suggest these metabolites as candidate early biomarkers of cardiotoxicity. Metabolomics analyses of plasma and heart tissue from male B6C3F sub(1) mice dosed weekly with 3mgkg super(-1) doxorubicin or saline for 2, 3, 4, 6 or 8weeks (cumulative doses of 6, 9, 12, 18 and 24mgkg super(-1), respectively) identified potential early stage injury biomarkers of doxorubicin-induced cardiotoxicity. Select metabolites were altered after the 6mgkg super(-1) cumulative dose whereas myocardial injury and cardiac pathology were not noted until after the 18 and 24mgkg super(-1) cumulative doses, respectively. JF - Journal of Applied Toxicology AU - Schnackenberg, Laura K AU - Pence, Lisa AU - Vijay, Vikrant AU - Moland, Carrie L AU - George, Nysia AU - Cao, Zhijun AU - Yu, Li-Rong AU - Fuscoe, James C AU - Beger, Richard D AU - Desai, Varsha G AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, Jefferson, Arkansas, 72079, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1486 EP - 1495 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 36 IS - 11 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - Pathology KW - Injuries KW - Chemotherapy KW - Metabolites KW - Veins KW - N.M.R. KW - NMR KW - Tricarboxylic acid cycle KW - Bioindicators KW - Biogenic amines KW - Heart KW - Hydroxyproline KW - Amino acids KW - Mice KW - Amines KW - biomarkers KW - Serotonin KW - Doxorubicin KW - Putrescine KW - Lactic acid KW - metabolomics KW - X 24390:Radioactive Materials KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827934489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Early+metabolomics+changes+in+heart+and+plasma+during+chronic+doxorubicin+treatment+in+B6C3F+sub%281%29+mice&rft.au=Schnackenberg%2C+Laura+K%3BPence%2C+Lisa%3BVijay%2C+Vikrant%3BMoland%2C+Carrie+L%3BGeorge%2C+Nysia%3BCao%2C+Zhijun%3BYu%2C+Li-Rong%3BFuscoe%2C+James+C%3BBeger%2C+Richard+D%3BDesai%2C+Varsha+G&rft.aulast=Schnackenberg&rft.aufirst=Laura&rft.date=2016-11-01&rft.volume=36&rft.issue=11&rft.spage=1486&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3307 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Heart; Biogenic amines; Hydroxyproline; Amino acids; Injuries; Chemotherapy; Metabolites; biomarkers; Doxorubicin; Serotonin; Veins; Putrescine; Lactic acid; N.M.R.; Tricarboxylic acid cycle; metabolomics; Bioindicators; Pathology; Mice; NMR; Amines DO - http://dx.doi.org/10.1002/jat.3307 ER - TY - JOUR T1 - The Perils of Integrating Wellness and Safety and Health and the Possibility of a Worker-Oriented Alternative AN - 1826876515 AB - In response to the article by Michael B. Lax, MD entitled "The perils of integrating wellness and safety and health and the possibility of a worker-oriented alternative," the National Institute for Occupational Safety and Health (NIOSH) provides updated information on the current focus and priorities and addresses concerns raised regarding the Total Worker Health® initiative. Many of the concerns and criticisms in the report echo those NIOSH publicly shares on a regular basis. The theory and practice of Total Worker Health (TWH) continues to evolve in response to valuable stakeholder input like that provided by Dr. Lax. In 2015, NIOSH updated the TWH concept to emphasize the main focus of TWH is the primacy of traditional health protection which prioritizes employer responsibilities for the organization of work over individual worker health behaviors. NIOSH acknowledges the past lack of "fit" between theory and practice in some publications of TWH-funded grantees as Dr. Lax points out. NIOSH is hopeful that the solicitation of new research, which is now underway, will clarify the work-centered priorities for TWH-funded research. Based on input from Dr. Lax and other stakeholders, NIOSH looks forward to contributing more effectively to protecting and promoting worker safety and health in the new twenty-first century world of work. JF - New Solutions : a Journal of Environmental and Occupational Health Policy : NS AU - Howard, John AU - Chosewood, L Casey AU - Hudson, Heidi L AD - National Institute for Occupational Safety and Health, Office of the Director, Washington, DC, USA ; National Institute for Occupational Safety and Health, Office for Total Worker Health, Atlanta, GA, USA ; National Institute for Occupational Safety and Health, Office for Total Worker Health, Cincinnati, OH, USA ; National Institute for Occupational Safety and Health, Office of the Director, Washington, DC, USA Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 345 EP - 348 CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 26 IS - 3 SN - 1048-2911 KW - Environmental Studies KW - total worker health KW - worksite wellness KW - integration of worksite health promotion and health protection KW - worker well-being KW - Employers KW - Publications KW - Work KW - Interest Groups KW - Occupational Safety and Health KW - Environmental Policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826876515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Application+of+a+Probabilistic+Framework+to+a+Biologically+Based+Dose-Response+Pregnancy+Model+to+Evaluate+Thyroidal+Effects+for+Environmental+Exposures+to+Perchlorate&rft.au=Lumen%2C+A&rft.aulast=Lumen&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Name - National Institute for Occupational Safety & Health N1 - Copyright - © The Author(s) 2016 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1177/1048291116656631 ER - TY - JOUR T1 - Ambient Air Pollution Exposures and Risk of Parkinson Disease. AN - 1826702958; 27285422 AB - Few epidemiologic studies have evaluated the effects of air pollution on the risk of Parkinson disease (PD). We investigated the associations of long-term residential concentrations of ambient particulate matter (PM) < 10 μm in diameter (PM10) and < 2.5 μm in diameter (PM2.5) and nitrogen dioxide (NO2) in relation to PD risk. Our nested case-control analysis included 1,556 self-reported physician-diagnosed PD cases identified between 1995 and 2006 and 3,313 controls frequency-matched on age, sex, and race. We geocoded home addresses reported in 1995-1996 and estimated the average ambient concentrations of PM10, PM2.5, and NO2 using a national fine-scale geostatistical model incorporating roadway information and other geographic covariates. Air pollutant exposures were analyzed as both quintiles and continuous variables, adjusting for matching variables and potential confounders. We observed no statistically significant overall association between PM or NO2 exposures and PD risk. However, in preplanned subgroup analyses, a higher risk of PD was associated with higher exposure to PM10 (ORQ5 vs. Q1 = 1.65; 95% CI: 1.11, 2.45; p-trend = 0.02) among women, and with higher exposure to PM2.5 (ORQ5 vs. Q1 = 1.29; 95% CI: 0.94, 1.76; p-trend = 0.04) among never smokers. In post hoc analyses among female never smokers, both PM2.5 (ORQ5 vs. Q1 = 1.79; 95% CI: 1.01, 3.17; p-trend = 0.05) and PM10 (ORQ5 vs. Q1 = 2.34; 95% CI: 1.29, 4.26; p-trend = 0.01) showed positive associations with PD risk. Analyses based on continuous exposure variables generally showed similar but nonsignificant associations. Overall, we found limited evidence for an association between exposures to ambient PM10, PM2.5, or NO2 and PD risk. The suggestive evidence that exposures to PM2.5 and PM10 may increase PD risk among female never smokers warrants further investigation. Citation: Liu R, Young MT, Chen JC, Kaufman JD, Chen H. 2016. Ambient air pollution exposures and risk of Parkinson disease. Environ Health Perspect 124:1759-1765; http://dx.doi.org/10.1289/EHP135. JF - Environmental health perspectives AU - Liu, Rui AU - Young, Michael T AU - Chen, Jiu-Chiuan AU - Kaufman, Joel D AU - Chen, Honglei AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1759 EP - 1765 VL - 124 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826702958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Ambient+Air+Pollution+Exposures+and+Risk+of+Parkinson+Disease.&rft.au=Liu%2C+Rui%3BYoung%2C+Michael+T%3BChen%2C+Jiu-Chiuan%3BKaufman%2C+Joel+D%3BChen%2C+Honglei&rft.aulast=Liu&rft.aufirst=Rui&rft.date=2016-11-01&rft.volume=124&rft.issue=11&rft.spage=1759&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 ER - TY - JOUR T1 - Nitrate from Drinking Water and Diet and Bladder Cancer Among Postmenopausal Women in Iowa. AN - 1826700831; 27258851 AB - Nitrate is a drinking water contaminant arising from agricultural sources, and it is a precursor in the endogenous formation of N-nitroso compounds (NOC), which are possible bladder carcinogens. We investigated the ingestion of nitrate and nitrite from drinking water and diet and bladder cancer risk in women. We identified incident bladder cancers among a cohort of 34,708 postmenopausal women in Iowa (1986-2010). Dietary nitrate and nitrite intakes were estimated from a baseline food frequency questionnaire. Drinking water source and duration were assessed in a 1989 follow-up. For women using public water supplies (PWS) > 10 years (n = 15,577), we estimated average nitrate (NO3-N) and total trihalomethane (TTHM) levels and the number of years exceeding one-half the maximum contaminant level (NO3-N: 5 mg/L, TTHM: 40 μg/mL) from historical monitoring data. We computed hazard ratios (HRs) and 95% confidence intervals (CIs), and assessed nitrate interactions with TTHM and with modifiers of NOC formation (smoking, vitamin C). We identified 258 bladder cancer cases, including 130 among women > 10 years at their PWS. In multivariable-adjusted models, we observed nonsignificant associations among women in the highest versus lowest quartile of average drinking water nitrate concentration (HR = 1.48; 95% CI: 0.92, 2.40; ptrend = 0.11), and we found significant associations among those exposed ≥ 4 years to drinking water with > 5 mg/L NO3-N (HR = 1.62; 95% CI: 1.06, 2.47; ptrend = 0.03) compared with women having 0 years of comparable exposure. TTHM adjustment had little influence on associations, and we observed no modification by vitamin C intake. Relative to a common reference group of never smokers with the lowest nitrate exposures, associations were strongest for current smokers with the highest nitrate exposures (HR = 3.67; 95% CI: 1.43, 9.38 for average water NO3-N and HR = 3.48; 95% CI: 1.20, 10.06 and ≥ 4 years > 5 mg/L, respectively). Dietary nitrate and nitrite intakes were not associated with bladder cancer. Long-term ingestion of elevated nitrate in drinking water was associated with an increased risk of bladder cancer among postmenopausal women. Citation: Jones RR, Weyer PJ, DellaValle CT, Inoue-Choi M, Anderson KE, Cantor KP, Krasner S, Robien K, Beane Freeman LE, Silverman DT, Ward MH. 2016. Nitrate from drinking water and diet and bladder cancer among postmenopausal women in Iowa. Environ Health Perspect 124:1751-1758; http://dx.doi.org/10.1289/EHP191. JF - Environmental health perspectives AU - Jones, Rena R AU - Weyer, Peter J AU - DellaValle, Curt T AU - Inoue-Choi, Maki AU - Anderson, Kristin E AU - Cantor, Kenneth P AU - Krasner, Stuart AU - Robien, Kim AU - Freeman, Laura E Beane AU - Silverman, Debra T AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1751 EP - 1758 VL - 124 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826700831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Regulatory+Perspective+for+Nonclinical+Development+and+Safety+Assessment+of+Antibody-+Drug+Conjugates&rft.au=Ricci%2C+S&rft.aulast=Ricci&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Rheumatoid Arthritis in Agricultural Health Study Spouses: Associations with Pesticides and Other Farm Exposures. AN - 1826699916; 27285288 AB - Farming has been associated with rheumatoid arthritis (RA), but the role of pesticides is not known. We examined associations between RA and pesticides or other agricultural exposures among female spouses of licensed pesticide applicators in the Agricultural Health Study. Women were enrolled between 1993 and 1997 and followed through 2010. Cases (n = 275 total, 132 incident), confirmed by a physician or by self-reported use of disease modifying antirheumatic drugs, were compared with noncases (n = 24,018). Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models adjusted for age, state, and smoking pack-years. Overall, women with RA were somewhat more likely to have reported lifetime use of any specific pesticide versus no pesticides (OR = 1.4; 95% CI: 1.0, 1.6). Of the 15 pesticides examined, maneb/mancozeb (OR = 3.3; 95% CI: 1.5, 7.1) and glyphosate (OR = 1.4; 95% CI: 1.0, 2.1) were associated with incident RA compared with no pesticide use. An elevated, but non-statistically significant association with incident RA was seen for DDT (OR = 1.9; 95% CI: 0.97, 3.6). Incident RA was also associated with the application of chemical fertilizers (OR = 1.7; 95% CI: 1.1, 2.7) and cleaning with solvents (OR = 1.6; 95% CI: 1.1, 2.4), but inversely associated with lifetime livestock exposure as a child and adult (OR = 0.48; 95% CI: 0.24, 0.97) compared with no livestock exposure. Our results suggest that specific agricultural pesticides, solvents, and chemical fertilizers may increase the risk of RA in women, while exposures involving animal contact may be protective. Citation: Parks CG, Hoppin JA, De Roos AJ, Costenbader KH, Alavanja MC, Sandler DP. 2016. Rheumatoid arthritis in Agricultural Health Study spouses: associations with pesticides and other farm exposures. Environ Health Perspect 124:1728-1734; http://dx.doi.org/10.1289/EHP129. JF - Environmental health perspectives AU - Parks, Christine G AU - Hoppin, Jane A AU - De Roos, Anneclaire J AU - Costenbader, Karen H AU - Alavanja, Michael C AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1728 EP - 1734 VL - 124 IS - 11 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826699916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Rheumatoid+Arthritis+in+Agricultural+Health+Study+Spouses%3A+Associations+with+Pesticides+and+Other+Farm+Exposures.&rft.au=Parks%2C+Christine+G%3BHoppin%2C+Jane+A%3BDe+Roos%2C+Anneclaire+J%3BCostenbader%2C+Karen+H%3BAlavanja%2C+Michael+C%3BSandler%2C+Dale+P&rft.aulast=Parks&rft.aufirst=Christine&rft.date=2016-11-01&rft.volume=124&rft.issue=11&rft.spage=1728&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Distance to testing sites and its association with timing of HIV diagnosis AN - 1818448099 AB - Early HIV diagnosis enables prompt treatment initiation, thereby contributing to decreased morbidity, mortality, and transmission. We aimed to describe the association between distance from residence to testing sites and HIV disease stage at diagnosis. Using HIV surveillance data, we identified all new HIV diagnoses made at publicly funded testing sites in central North Carolina during 2005-2013. Early-stage HIV was defined as acute HIV (antibody-negative test with a positive HIV RNA) or recent HIV (normalized optical density <0.8 on the BED assay for non-AIDS cases); remaining diagnoses were considered post-early-stage HIV. Street distance between residence at diagnosis and (1) the closest testing site and (2) the diagnosis site was dichotomized at 5 miles. We fit log-binomial models using generalized estimating equations to estimate prevalence ratios (PR) and robust 95% confidence intervals (CI) for post-early-stage diagnoses by distance. Models were adjusted for race/ethnicity and testing period. Most of the 3028 new diagnoses were black (N = 2144; 70.8%), men who have sex with men (N = 1685; 55.7%), and post-early-stage HIV diagnoses (N = 2010; 66.4%). Overall, 1145 (37.8%) cases traveled <5 miles for a diagnosis. Among cases traveling [greater than or equal to]5 miles for a diagnosis, 1273 (67.6%) lived <5 miles from a different site. Residing [greater than or equal to]5 miles from a testing site was not associated with post-early-stage HIV (adjusted PR, 95% CI: 0.98, 0.92-1.04), but traveling [greater than or equal to]5 miles for a diagnosis was associated with higher post-early HIV prevalence (1.07, 1.02-1.13). Most of the elevated prevalence observed in cases traveling [greater than or equal to]5 miles for a diagnosis occurred among those living <5 miles from a different site (1.09, 1.03-1.16). Modest increases in post-early-stage HIV diagnosis were apparent among persons living near a site, but choosing to travel longer distances to test. Understanding reasons for increased travel distances could improve accessibility and acceptability of HIV services and increase early diagnosis rates. JF - AIDS Care AU - Cope, Anna B AU - Powers, Kimberly A AU - Serre, Marc L AU - Escamilla, Veronica AU - Emch, Michael E AU - Leone, Peter A AU - Mobley, Victoria L AU - Miller, William C AD - Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA ; Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC, USA ; Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL, USA ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA; Department of Geography, University of North Carolina, Chapel Hill, NC, USA ; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ; North Carolina Department of Health and Human Services, Raleigh, NC, USA ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA; Division of Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA Y1 - 2016/11// PY - 2016 DA - Nov 2016 SP - 1423 EP - 1427 CY - London PB - Taylor & Francis Ltd. VL - 28 IS - 11 SN - 0954-0121 KW - Medical Sciences--Psychiatry And Neurology KW - Recent HIV infection KW - surveillance KW - HIV testing KW - geographic distance KW - barriers to testing KW - late diagnosis KW - Diagnostic testing KW - Accessibility KW - Morbidity-Mortality KW - Mortality KW - AIDS KW - Residence KW - Density KW - Morbidity KW - Confidence intervals KW - Ethnicity KW - HIV KW - Surveillance KW - Homosexuals KW - Men KW - Race KW - Diagnosis KW - Timing KW - Initiation KW - Human immunodeficiency virus--HIV KW - Acquired immune deficiency syndrome--AIDS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1818448099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Distance+to+testing+sites+and+its+association+with+timing+of+HIV+diagnosis&rft.au=Cope%2C+Anna+B%3BPowers%2C+Kimberly+A%3BSerre%2C+Marc+L%3BEscamilla%2C+Veronica%3BEmch%2C+Michael+E%3BLeone%2C+Peter+A%3BMobley%2C+Victoria+L%3BMiller%2C+William+C&rft.aulast=Cope&rft.aufirst=Anna&rft.date=2016-11-01&rft.volume=28&rft.issue=11&rft.spage=1423&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2016.1191599 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © 2016 Informa UK Limited, trading as Taylor & Francis Group N1 - Last updated - 2016-09-12 DO - http://dx.doi.org/10.1080/09540121.2016.1191599 ER - TY - JOUR T1 - Size- and coating-dependent cytotoxicity and genotoxicity of silver nanoparticles evaluated using in vitro standard assays. AN - 1814659617; 27441588 AB - The physicochemical characteristics of silver nanoparticles (AgNPs) may greatly alter their toxicological potential. To explore the effects of size and coating on the cytotoxicity and genotoxicity of AgNPs, six different types of AgNPs, having three different sizes and two different coatings, were investigated using the Ames test, mouse lymphoma assay (MLA) and in vitro micronucleus assay. The genotoxicities of silver acetate and silver nitrate were evaluated to compare the genotoxicity of nanosilver to that of ionic silver. The Ames test produced inconclusive results for all types of the silver materials due to the high toxicity of silver to the test bacteria and the lack of entry of the nanoparticles into the cells. Treatment of L5718Y cells with AgNPs and ionic silver resulted in concentration-dependent cytotoxicity, mutagenicity in the Tk gene and the induction of micronuclei from exposure to nearly every type of the silver materials. Treatment of TK6 cells with these silver materials also resulted in concentration-dependent cytotoxicity and significantly increased micronucleus frequency. With both the MLA and micronucleus assays, the smaller the AgNPs, the greater the cytotoxicity and genotoxicity. The coatings had less effect on the relative genotoxicity of AgNPs than the particle size. Loss of heterozygosity analysis of the induced Tk mutants indicated that the types of mutations induced by AgNPs were different from those of ionic silver. These results suggest that AgNPs induce cytotoxicity and genotoxicity in a size- and coating-dependent manner. Furthermore, while the MLA and in vitro micronucleus assay (in both types of cells) are useful to quantitatively measure the genotoxic potencies of AgNPs, the Ames test cannot. JF - Nanotoxicology AU - Guo, Xiaoqing AU - Li, Yan AU - Yan, Jian AU - Ingle, Taylor AU - Jones, Margie Yvonne AU - Mei, Nan AU - Boudreau, Mary D AU - Cunningham, Candice K AU - Abbas, Mazhar AU - Paredes, Angel M AU - Zhou, Tong AU - Moore, Martha M AU - Howard, Paul C AU - Chen, Tao AD - a Division of Genetic and Molecular Toxicology . ; b Nanotechnology Core Facility , and. ; c Division of Biochemical Toxicology , National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson , AR , USA . ; e Center for Veterinary Medicine, U.S. Food and Drug Administration , Rockville , MD , USA. Y1 - 2016/11// PY - 2016 DA - November 2016 SP - 1373 EP - 1384 VL - 10 IS - 9 KW - Index Medicus KW - genotoxicity KW - in vitro micronucleus assay KW - Ames test KW - mouse lymphoma assay KW - silver nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814659617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Size-+and+coating-dependent+cytotoxicity+and+genotoxicity+of+silver+nanoparticles+evaluated+using+in+vitro+standard+assays.&rft.au=Guo%2C+Xiaoqing%3BLi%2C+Yan%3BYan%2C+Jian%3BIngle%2C+Taylor%3BJones%2C+Margie+Yvonne%3BMei%2C+Nan%3BBoudreau%2C+Mary+D%3BCunningham%2C+Candice+K%3BAbbas%2C+Mazhar%3BParedes%2C+Angel+M%3BZhou%2C+Tong%3BMoore%2C+Martha+M%3BHoward%2C+Paul+C%3BChen%2C+Tao&rft.aulast=Guo&rft.aufirst=Xiaoqing&rft.date=2016-11-01&rft.volume=10&rft.issue=9&rft.spage=1373&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.1080%2F17435390.2016.1214764 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/17435390.2016.1214764 ER - TY - JOUR T1 - Improving drug safety with a systems pharmacology approach. AN - 1826702552; 27287422 AB - Systems pharmacology is used to mechanistically analyze drug-adverse drug reaction (ADRs) pairs and is a promising solution to the complex problem of understanding mechanisms of toxicity. In this research, we have explored the feasibility of retrospectively mapping population-level adverse events from the FDA Adverse Event Reporting System (FAERS) to chemical and biological databases to identify drug safety signals and the underlying molecular mechanisms. We used an analytic platform - Molecular Analysis of Side Effects (MASE™). For this purpose, we selected the adverse event of severe and potentially fatal cutaneous reactions (SCARs) that are associated with acetaminophen (APAP). SCARs encompass the continuum between Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). We found a statistically significant association between APAP and TEN, the most severe form of SCARs. We also explored the influence of APAP on other classes of drugs commonly associated with SCARs. We found that APAP significantly reduced the risk of SCARs commonly associated with carbamazepine (CBZ). We used molecular docking simulations to propose a mechanism for APAP's reduction in CBZ-induced SCARs which is competitive inhibition of the binding of CBZ to HLA-B*15:02. We conclude that systems pharmacology can complement established surveillance methodologies by providing a means to undertake an independent investigation and review of the mechanisms by which drugs cause adverse events. Copyright © 2016. Published by Elsevier B.V. JF - European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences AU - Schotland, Peter AU - Bojunga, Niels AU - Zien, Alexander AU - Trame, Mirjam Nadine AU - Lesko, Lawrence J AD - The Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, United States; Office of Clinical Pharmacology, Office of Translational Sciences, US Food and Drug Administration, United States. ; Molecular Health, Heidelberg, Germany. ; The Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, United States. ; The Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, United States. Electronic address: llesko@cop.ufl.edu. Y1 - 2016/10/30/ PY - 2016 DA - 2016 Oct 30 SP - 84 EP - 92 VL - 94 KW - Systems pharmacology KW - Informatics KW - Stevens-Johnson Syndrome KW - Drug safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826702552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmaceutical+sciences+%3A+official+journal+of+the+European+Federation+for+Pharmaceutical+Sciences&rft.atitle=Improving+drug+safety+with+a+systems+pharmacology+approach.&rft.au=Roberts%2C+J%3BErdely%2C+A&rft.aulast=Roberts&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ejps.2016.06.009 ER - TY - JOUR T1 - Concentrations of Polychlorinated Biphenyls and Organochlorine Pesticides in Umbilical Cord Blood Serum of Newborns in Kingston, Jamaica. AN - 1835511789; 27775677 AB - To date much of the biomonitoring related to exposure to polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides is from middle to high income countries, including the U.S., Canada and Europe, but such data are lacking for the majority of low to middle income countries. Using data from 64 pregnant mothers who were enrolled in 2011, we aimed to assess the concentrations of the aforementioned toxins in umbilical cord blood serum of 67 Jamaican newborns. For 97 of the 100 PCB congeners and 16 of the 17 OC pesticides, all (100%) concentrations were below their respective limits of detection (LOD). Mean (standard deviation (SD)) lipid-adjusted concentrations in cord blood serum for congeners PCB-153, PCB-180, PCB-206 and total PCB were 14.25 (3.21), 7.16 (1.71), 7.30 (1.74) and 28.15 (6.03) ng/g-lipid, respectively. The means (SD) for the 4,4'-dichlorodiphenyldichloroethylene (DDE)-hexane fraction and total-DDE were 61.61 (70.78) and 61.60 (70.76) ng/g-lipid, respectively. Compared to the U.S. and Canada, the concentrations of these toxins were lower in cord-blood serum of Jamaican newborns. We discuss that these differences could be partly due to differences in dietary patterns in these countries. Despite limitations in our dataset, our results provide information on the investigated toxins in cord blood serum that could serve as a reference for Jamaican newborns. JF - International journal of environmental research and public health AU - Rahbar, Mohammad H AU - Samms-Vaughan, Maureen AU - Hessabi, Manouchehr AU - Dickerson, Aisha S AU - Lee, MinJae AU - Bressler, Jan AU - Tomechko, Sara E AU - Moreno, Emily K AU - Loveland, Katherine A AU - Desai, Charlene Coore AU - Shakespeare-Pellington, Sydonnie AU - Reece, Jody-Ann AU - Morgan, Renee AU - Geiger, Matthew J AU - O'Keefe, Michael E AU - Grove, Megan L AU - Boerwinkle, Eric AD - Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Mohammad.H.Rahbar@uth.tmc.edu. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. msammsvaughan@gmail.com. ; Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Manouchehr.Hessabi@uth.tmc.edu. ; Biostatistics/Epidemiology/Research Design (BERD) Component, Center for Clinical and Translational Sciences (CCTS), University of Texas Health Science Center at Houston, Houston, TX 77030, USA. adickerson@hsph.harvard.edu. ; Division of Clinical and Translational Sciences, Department of Internal Medicine, University of Texas McGovern Medical School at Houston, Houston, TX 77030, USA. MinJae.Lee@uth.tmc.edu. ; Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Jan.Bressler@uth.tmc.edu. ; Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. sara.tomechko@gmail.com. ; Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. MorenoE@michigan.gov. ; Department of Psychiatry and Behavioral Sciences, University of Texas McGovern Medical School at Houston, Houston, TX 77054, USA. Katherine.A.Loveland@uth.tmc.edu. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. cooredesai@googlemail.com. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. sydonniesp@gmail.com. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. jodyreece@yahoo.com. ; Department of Child & Adolescent Health, The University of the West Indies (UWI), Mona Campus, Kingston 7, Jamaica. renee.n.morgan@gmail.com. ; Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. geigerm@michigan.gov. ; Division of Chemistry and Toxicology, Michigan Department of Health and Human Services (MDHHS), Lansing, MI 48906, USA. okeefem@michigan.gov. ; Human Genetics Center, University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Megan.L.Grove@uth.tmc.edu. ; Division of Epidemiology, Human Genetics, and Environmental Sciences (EHGES), University of Texas School of Public Health at Houston, Houston, TX 77030, USA. Eric.Boerwinkle@uth.tmc.edu. Y1 - 2016/10/21/ PY - 2016 DA - 2016 Oct 21 VL - 13 IS - 10 KW - polychlorinated biphenyls (PCBs) KW - organochlorine (OC) pesticides KW - Jamaica KW - newborns KW - Kingston UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835511789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+environmental+research+and+public+health&rft.atitle=Concentrations+of+Polychlorinated+Biphenyls+and+Organochlorine+Pesticides+in+Umbilical+Cord+Blood+Serum+of+Newborns+in+Kingston%2C+Jamaica.&rft.au=Rahbar%2C+Mohammad+H%3BSamms-Vaughan%2C+Maureen%3BHessabi%2C+Manouchehr%3BDickerson%2C+Aisha+S%3BLee%2C+MinJae%3BBressler%2C+Jan%3BTomechko%2C+Sara+E%3BMoreno%2C+Emily+K%3BLoveland%2C+Katherine+A%3BDesai%2C+Charlene+Coore%3BShakespeare-Pellington%2C+Sydonnie%3BReece%2C+Jody-Ann%3BMorgan%2C+Renee%3BGeiger%2C+Matthew+J%3BO%27Keefe%2C+Michael+E%3BGrove%2C+Megan+L%3BBoerwinkle%2C+Eric&rft.aulast=Rahbar&rft.aufirst=Mohammad&rft.date=2016-10-21&rft.volume=13&rft.issue=10&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Exploring Oxidative Reactions in Hemoglobin Variants Using Mass Spectrometry: Lessons for Engineering Oxidatively Stable Oxygen Therapeutics. AN - 1835503592; 27626360 AB - Worldwide demand has driven the development of hemoglobin (Hb)-based oxygen carriers (HBOCs) as potential acellular oxygen therapeutics. HBOCs have the potential to provide an oxygen bridge to patients and minimize current problems associated with supply and storage of donated blood. However, to date, safety and efficacy issues have hampered the approval of viable HBOCs in the United States. These previous efforts have underscored the need for a better molecular understanding of toxicity to design safe and oxidatively stable HBOCs. Recent Advances: High-resolution accurate mass (HRAM) mass spectrometry (MS) has recently become a versatile tool in characterizing oxidative post-translational modifications that occur in Hb. When integrated with other analytical techniques, HRAM data have been invaluable in providing mechanistic insight into the extent of oxidative modification by quantifying oxidation in amino acids near the reactive heme or at specific "oxidative hotspots." In addition to providing a deeper understanding of Hb oxidative toxicity, HRAM MS studies are currently being used toward developing suitable HBOCs using a "two-prong" strategy that involves (i) understanding the mechanism of Hb toxicity by evaluating mutant Hbs identified in patients with hemoglobinopathies and (ii) utilizing this information toward designing against (or for) these reactions in acellular oxygen therapeutics that will result in oxidatively stable protein. Future HRAM studies are aimed at fully characterizing engineered candidate HBOCs to determine the most oxidatively stable protein while retaining oxygen carrying function in vivo. Antioxid. Redox Signal. 00, 000-000. JF - Antioxidants & redox signaling AU - Strader, Michael Brad AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research , Food and Drug Administration, Silver Spring, Maryland. Y1 - 2016/10/20/ PY - 2016 DA - 2016 Oct 20 KW - mass spectrometry KW - oxidation reactions KW - hemoglobin mutants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835503592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+%26+redox+signaling&rft.atitle=Exploring+Oxidative+Reactions+in+Hemoglobin+Variants+Using+Mass+Spectrometry%3A+Lessons+for+Engineering+Oxidatively+Stable+Oxygen+Therapeutics.&rft.au=Strader%2C+Michael+Brad%3BAlayash%2C+Abdu+I&rft.aulast=Strader&rft.aufirst=Michael&rft.date=2016-10-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Antioxidants+%26+redox+signaling&rft.issn=1557-7716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Occurrence of aflatoxin B1 in baby foods marketed in Iran. AN - 1835438948; 27747874 AB - Aflatoxin B1 (AFB1 ), a toxic fungal metabolite that is found in baby foods, can lead to serious complications for children's health. In the present study, 48 commercial baby foods available in the Iranian market were investigated for the presence of AFB1 using a high performance liquid chromatography system that was equipped with post-column photochemical derivatization and a fluorescence detector. Thirty-three out of 48 samples (68.7%) were contaminated with AFB1 at median, maximum and mean concentration levels of 0.11, 15.15 and 2.602 ± 4.065 µg kg-1 , respectively. The AFB1 concentration in 39.6% of the samples was higher than the maximum level established in Iran for AFB1 within baby foods containing milk (0.5 µg kg-1 ). The incidence of AFB1 in rice, wheat and multigrain infant cereal samples was 90%, 25% and 100%, respectively, whereas rice-based baby foods contained the highest levels of AFB1 . In the present study, the finding of both high rates and high levels of AFB1 in cereal baby foods indicates the need to reduce AFB1 contamination in these products. Therefore, further monitoring and control of pre- and post-harvest, storage, and manufacturing processes is required. © 2016 Society of Chemical Industry. © 2016 Society of Chemical Industry. JF - Journal of the science of food and agriculture AU - Mottaghianpour, Ehsan AU - Nazari, Firouzeh AU - Mehrasbi, Mohammad Reza AU - Hosseini, Mir-Jamal AD - Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran. ; Food and Drug Administration-Iran University of Medical Sciences, Tehran, Iran. ; Department of Pharmacology and Toxicology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran. Y1 - 2016/10/16/ PY - 2016 DA - 2016 Oct 16 KW - HPLC KW - aflatoxin B1 KW - Iran KW - baby foods KW - contamination KW - photochemical derivatization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835438948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+science+of+food+and+agriculture&rft.atitle=Occurrence+of+aflatoxin+B1+in+baby+foods+marketed+in+Iran.&rft.au=Mottaghianpour%2C+Ehsan%3BNazari%2C+Firouzeh%3BMehrasbi%2C+Mohammad+Reza%3BHosseini%2C+Mir-Jamal&rft.aulast=Mottaghianpour&rft.aufirst=Ehsan&rft.date=2016-10-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+science+of+food+and+agriculture&rft.issn=1097-0010&rft_id=info:doi/10.1002%2Fjsfa.8092 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jsfa.8092 ER - TY - JOUR T1 - Bacterial Populations Associated with Smokeless Tobacco Products. AN - 1835369408; 27565615 AB - There are an estimated 8 million users of smokeless tobacco products (STPs) in the United States, and yet limited data on microbial populations within these products exist. To better understand the potential microbiological risks associated with STP use, a study was conducted to provide a baseline microbiological profile of STPs. A total of 90 samples, representing 15 common STPs, were purchased in metropolitan areas in Little Rock, AR, and Washington, DC, in November 2012, March 2013, and July 2013. Bacterial populations were evaluated using culture, pyrosequencing, and denaturing gradient gel electrophoresis (DGGE). Moist-snuff products exhibited higher levels of bacteria (average of 1.05 × 106 CFU/g STP) and diversity of bacterial populations than snus (average of 8.33 × 101 CFU/g STP) and some chewing tobacco products (average of 2.54 × 105 CFU/g STP). The most common species identified by culturing were Bacillus pumilus, B. licheniformis, B. safensis, and B. subtilis, followed by members of the genera Oceanobacillus, Staphylococcus, and Tetragenococcus. Pyrosequencing analyses of the 16S rRNA genes identified the genera Tetragenococcus, Carnobacterium, Lactobacillus, Geobacillus, Bacillus, and Staphylococcus as the predominant taxa. Several species identified are of possible concern due to their potential to cause opportunistic infections and reported abilities to reduce nitrates to nitrites, which may be an important step in the formation of carcinogenic tobacco-specific N'-nitrosamines. This report provides a microbiological baseline to help fill knowledge gaps associated with microbiological risks of STPs and to inform potential regulations regarding manufacture and testing of STPs. It is estimated that there 8 million users of smokeless tobacco products (STPs) in the United States; however, there are limited data on microbial populations that exist within these products. The current study was undertaken to better understand the potential microbiological risks associated with STP use and provide a baseline microbiological profile of STPs. Several bacterial species were identified that are of possible concern due to their potential to cause opportunistic infections. In addition, some species have abilities to reduce nitrates to nitrites, which may be an important step in the formation of carcinogenic tobacco-specific N'-nitrosamines. Overall, this report provides a microbiological baseline to help fill knowledge gaps related to the microbiological risks of STPs and to inform potential regulations regarding the manufacture and testing of STPs. Copyright © 2016, American Society for Microbiology. All Rights Reserved. JF - Applied and environmental microbiology AU - Han, Jing AU - Sanad, Yasser M AU - Deck, Joanna AU - Sutherland, John B AU - Li, Zhong AU - Walters, Matthew J AU - Duran, Norma AU - Holman, Matthew R AU - Foley, Steven L AD - Division of Microbiology, FDA, National Center for Toxicological Research, Jefferson, Arkansas, USA. ; Division of Product Science, FDA, Center for Tobacco Products, Silver Spring, Maryland, USA. ; Division of Microbiology, FDA, National Center for Toxicological Research, Jefferson, Arkansas, USA steven.foley@fda.hhs.gov. Y1 - 2016/10/15/ PY - 2016 DA - 2016 Oct 15 SP - 6273 EP - 6283 VL - 82 IS - 20 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835369408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Bacterial+Populations+Associated+with+Smokeless+Tobacco+Products.&rft.au=Han%2C+Jing%3BSanad%2C+Yasser+M%3BDeck%2C+Joanna%3BSutherland%2C+John+B%3BLi%2C+Zhong%3BWalters%2C+Matthew+J%3BDuran%2C+Norma%3BHolman%2C+Matthew+R%3BFoley%2C+Steven+L&rft.aulast=Han&rft.aufirst=Jing&rft.date=2016-10-15&rft.volume=82&rft.issue=20&rft.spage=6273&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Acute Occupational Pesticide-Related Illness and Injury -United States, 2007-2011. AN - 1835427643; 27736824 AB - CDC's National Institute for Occupational Safety and Health (NIOSH) collects data on acute pesticide-related illness and injury reported by 12 states (California, Florida, Iowa, Louisiana, Michigan, Nebraska, North Carolina, New Mexico, New York, Oregon, Texas, and Washington). This report summarizes the data on illnesses and injuries arising from occupational exposure to conventional pesticides from 2007 through 2011. This report is a part of the Summary of Notifiable Noninfectious Conditions and Disease Outbreaks - United States, which encompasses various surveillance years but is being published in 2016 (1). The Summary of Notifiable Noninfectious Conditions and Disease Outbreaks appears in the same volume of MMWR as the annual Summary of Notifiable Infectious Diseases (2). In a separate report, data on illnesses and injuries from nonoccupational exposure to pesticides during 2007-2011 are summarized (3). JF - MMWR. Morbidity and mortality weekly report AU - Calvert, Geoffrey M AU - Beckman, John AU - Prado, Joanne Bonnar AU - Bojes, Heidi AU - Schwartz, Abby AU - Mulay, Prakash AU - Leinenkugel, Kathy AU - Higgins, Sheila AU - Lackovic, Michelle AU - Waltz, Justin AU - Stover, Derry AU - Moraga-McHaley, Stephanie AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC. ; Public Health Institute and Occupational Health Branch, California Department of Public Health, Richmond, California. ; Office of Environmental Health, Safety, and Toxicology, Washington State Department of Health, Olympia, Washington. ; Environmental and Injury Epidemiology and Toxicology Unit, Texas Department of State Health Services, Austin, Texas. ; Division of Environmental Health, Michigan Department of Health and Human Services, Lansing, Michigan. ; Florida Department of Health, Tallahassee, Florida. ; Iowa Department of Public Health, Des Moines, Iowa. ; North Carolina Department of Health and Human Services, Raleigh, North Carolina. ; Louisiana Department of Health and Hospitals, New Orleans, Louisiana. ; Center for Health Protection, Public Health Division, Oregon Health Authority, Portland, Oregon. ; Nebraska Department of Health and Human Services, Lincoln, Nebraska. ; New Mexico Department of Health, Albuquerque, New Mexico. Y1 - 2016/10/14/ PY - 2016 DA - 2016 Oct 14 SP - 11 EP - 16 VL - 63 IS - 55 KW - Pesticides KW - 0 KW - Index Medicus KW - Acute Disease KW - Humans KW - United States -- epidemiology KW - Male KW - Female KW - Occupational Injuries -- chemically induced KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Occupational Injuries -- epidemiology KW - Occupational Diseases -- chemically induced KW - Population Surveillance KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835427643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+mortality+weekly+report&rft.atitle=Acute+Occupational+Pesticide-Related+Illness+and+Injury+-United+States%2C+2007-2011.&rft.au=Calvert%2C+Geoffrey+M%3BBeckman%2C+John%3BPrado%2C+Joanne+Bonnar%3BBojes%2C+Heidi%3BSchwartz%2C+Abby%3BMulay%2C+Prakash%3BLeinenkugel%2C+Kathy%3BHiggins%2C+Sheila%3BLackovic%2C+Michelle%3BWaltz%2C+Justin%3BStover%2C+Derry%3BMoraga-McHaley%2C+Stephanie&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2016-10-14&rft.volume=63&rft.issue=55&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+mortality+weekly+report&rft.issn=1545-861X&rft_id=info:doi/10.15585%2Fmmwr.mm6355a3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-12 N1 - Date created - 2016-10-13 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.15585/mmwr.mm6355a3 ER - TY - JOUR T1 - Draft Genome Sequences of Four Salmonella enterica Strains Isolated from Turkey-Associated Sources. AN - 1835422505; 27738037 AB - We report the draft genomes of four Salmonella enterica isolates evaluated for the contribution of plasmids to virulence. Strains SE163A, SE696A, and SE710A carry plasmids demonstrated to facilitate plasmid-associated virulence, while SE819 is less virulent and has been used as a recipient for conjugation experiments to assess plasmid-encoded virulence mechanisms. Copyright © 2016 Khajanchi et al. JF - Genome announcements AU - Khajanchi, Bijay K AU - Han, Jing AU - Gokulan, Kuppan AU - Zhao, Shaohua AU - Gies, Allen AU - Foley, Steven L AD - U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, USA bijay.khajanchi@fda.hhs.gov steven.foley@fda.hhs.gov. ; U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas, USA. ; U.S. Food and Drug Administration, Center for Veterinary Medicine, Laurel, Maryland, USA. ; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. Y1 - 2016/10/13/ PY - 2016 DA - 2016 Oct 13 VL - 4 IS - 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835422505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+announcements&rft.atitle=Draft+Genome+Sequences+of+Four+Salmonella+enterica+Strains+Isolated+from+Turkey-Associated+Sources.&rft.au=Khajanchi%2C+Bijay+K%3BHan%2C+Jing%3BGokulan%2C+Kuppan%3BZhao%2C+Shaohua%3BGies%2C+Allen%3BFoley%2C+Steven+L&rft.aulast=Khajanchi&rft.aufirst=Bijay&rft.date=2016-10-13&rft.volume=4&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/genomeA.01122-16 ER - TY - JOUR T1 - Trastuzumab cardiotoxicity: from clinical trials to experimental studies. AN - 1835401094; 27714776 AB - Epidermal growth factor receptor-2 (HER-2) is overexpressed in 20 to 25% of human breast cancers, which is associated with aggressive tumour growth and poor prognosis. Trastuzumab (Herceptin®) is a humanized monoclonal antibody directed against HER-2, the first highly selective form of therapy targeting HER-2 overexpressing tumours. Although initial trials indicated high efficacy and a favourable safety profile of the drug, the first large, randomized trial prompted a retrospective analysis of cardiac dysfunction in earlier trials utilizing trastuzumab. There has been ongoing debate on the cardiac safety of trastuzumab ever since, initiating numerous clinical and preclinical investigations to better understand the background of trastuzumab cardiotoxicity and evaluate its effects on patient morbidity. Here, we have given a comprehensive overview of our current knowledge on the cardiotoxicity of trastuzumab, primarily focusing on data from clinical trials and highlighting the main molecular mechanisms proposed. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - British journal of pharmacology AU - Nemeth, Balazs T AU - Varga, Zoltan V AU - Wu, Wen Jin AU - Pacher, Pal AD - Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD, USA. ; Division of Biotechnology Research and Review 1, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA. Y1 - 2016/10/07/ PY - 2016 DA - 2016 Oct 07 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835401094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+journal+of+pharmacology&rft.atitle=Trastuzumab+cardiotoxicity%3A+from+clinical+trials+to+experimental+studies.&rft.au=Nemeth%2C+Balazs+T%3BVarga%2C+Zoltan+V%3BWu%2C+Wen+Jin%3BPacher%2C+Pal&rft.aulast=Nemeth&rft.aufirst=Balazs&rft.date=2016-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=British+journal+of+pharmacology&rft.issn=1476-5381&rft_id=info:doi/10.1111%2Fbph.13643 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/bph.13643 ER - TY - GEN T1 - Proceedings of the 2016 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. AN - 1835520081; 27766933 JF - BMC bioinformatics AU - Wren, Jonathan D AU - Toby, Inimary AU - Hong, Huxiao AU - Nanduri, Bindu AU - Kaundal, Rakesh AU - Dozmorov, Mikhail G AU - Thakkar, Shraddha Y1 - 2016/10/06/ PY - 2016 DA - 2016 Oct 06 SP - 356 VL - 17 KW - Conferences KW - ISCB KW - MCBIOS KW - Bioinformatics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835520081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=BMC+bioinformatics&rft.atitle=Proceedings+of+the+2016+MidSouth+Computational+Biology+and+Bioinformatics+Society+%28MCBIOS%29+Conference.&rft.au=Wren%2C+Jonathan+D%3BToby%2C+Inimary%3BHong%2C+Huxiao%3BNanduri%2C+Bindu%3BKaundal%2C+Rakesh%3BDozmorov%2C+Mikhail+G%3BThakkar%2C+Shraddha&rft.aulast=Wren&rft.aufirst=Jonathan&rft.date=2016-10-06&rft.volume=17&rft.issue=&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=BMC+bioinformatics&rft.issn=1471-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-21 N1 - Date revised - 2017-02-08 N1 - Last updated - 2017-02-08 ER - TY - JOUR T1 - Application of dynamic topic models to toxicogenomics data. AN - 1835519794; 27766956 AB - All biological processes are inherently dynamic. Biological systems evolve transiently or sustainably according to sequential time points after perturbation by environment insults, drugs and chemicals. Investigating the temporal behavior of molecular events has been an important subject to understand the underlying mechanisms governing the biological system in response to, such as, drug treatment. The intrinsic complexity of time series data requires appropriate computational algorithms for data interpretation. In this study, we propose, for the first time, the application of dynamic topic models (DTM) for analyzing time-series gene expression data. A large time-series toxicogenomics dataset was studied. It contains over 3144 microarrays of gene expression data corresponding to rat livers treated with 131 compounds (most are drugs) at two doses (control and high dose) in a repeated schedule containing four separate time points (4-, 8-, 15- and 29-day). We analyzed, with DTM, the topics (consisting of a set of genes) and their biological interpretations over these four time points. We identified hidden patterns embedded in this time-series gene expression profiles. From the topic distribution for compound-time condition, a number of drugs were successfully clustered by their shared mode-of-action such as PPARɑ agonists and COX inhibitors. The biological meaning underlying each topic was interpreted using diverse sources of information such as functional analysis of the pathways and therapeutic uses of the drugs. Additionally, we found that sample clusters produced by DTM are much more coherent in terms of functional categories when compared to traditional clustering algorithms. We demonstrated that DTM, a text mining technique, can be a powerful computational approach for clustering time-series gene expression profiles with the probabilistic representation of their dynamic features along sequential time frames. The method offers an alternative way for uncovering hidden patterns embedded in time series gene expression profiles to gain enhanced understanding of dynamic behavior of gene regulation in the biological system. JF - BMC bioinformatics AU - Lee, Mikyung AU - Liu, Zhichao AU - Huang, Ruili AU - Tong, Weida AD - NIH/National Center for Advancing Translational Sciences, Rockville, MD, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, AR, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, AR, USA. weida.tong@fda.hhs.gov. Y1 - 2016/10/06/ PY - 2016 DA - 2016 Oct 06 SP - 368 VL - 17 KW - TG-GATEs KW - Dynamic topic model (DTM) KW - Latent Dirichlet model KW - Clustering KW - Topic modeling KW - Toxicogenomics KW - Times-series gene expression UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835519794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+bioinformatics&rft.atitle=Application+of+dynamic+topic+models+to+toxicogenomics+data.&rft.au=Lee%2C+Mikyung%3BLiu%2C+Zhichao%3BHuang%2C+Ruili%3BTong%2C+Weida&rft.aulast=Lee&rft.aufirst=Mikyung&rft.date=2016-10-06&rft.volume=17&rft.issue=&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=BMC+bioinformatics&rft.issn=1471-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - GEN T1 - State Regulations and Opioid Use among Disabled Adults. AN - 1835356303; 27705248 JF - The New England journal of medicine AU - Jones, Christopher M AU - Baldwin, Grant T AU - Tefera, Lemeneh Y1 - 2016/10/06/ PY - 2016 DA - 2016 Oct 06 SP - 1396 EP - 1397 VL - 375 IS - 14 KW - Analgesics, Opioid KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Humans KW - Adult KW - Disabled Persons KW - Analgesics, Opioid -- therapeutic use KW - Opioid-Related Disorders -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835356303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Effect+of+interferents+on+the+performance+of+direct-reading+organic+vapor+monitors&rft.au=LeBouf%2C+Ryan+F%3BCoffey%2C+Christopher+C&rft.aulast=LeBouf&rft.aufirst=Ryan&rft.date=2015-03-04&rft.volume=65&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2014.986308 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-25 N1 - Date created - 2016-10-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: N Engl J Med. 2016 Oct 6;375(14 ):1396-1397 [27705247] Comment On: N Engl J Med. 2016 Jul 7;375(1):44-53 [27332619] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Occupational exposures to new dry cleaning solvents: High-flashpoint hydrocarbons and butylal. AN - 1812888836; 27105306 AB - The dry cleaning industry is moving away from using perchloroethylene. Occupational exposures to two alternative dry cleaning solvents, butylal and high-flashpoint hydrocarbons, have not been well characterized. We evaluated four dry cleaning shops that used these alternative solvents. The shops were staffed by Korean- and Cantonese-speaking owners, and Korean-, Cantonese-, and Spanish-speaking employees. Because most workers had limited English proficiency we used language services in our evaluations. In two shops we collected personal and area air samples for butylal. We also collected air samples for formaldehyde and butanol, potential hydrolysis products of butylal. Because there are no occupational exposure limits for butylal, we assessed employee health risks using control banding tools. In the remaining two shops we collected personal and area air samples for high-flashpoint hydrocarbon solvents. In all shops the highest personal airborne exposures occurred when workers loaded and unloaded the dry cleaning machines and pressed dry cleaned fabrics. The air concentrations of formaldehyde and butanol in the butylal shops were well below occupational exposure limits. Likewise, the air concentrations of high-flashpoint hydrocarbons were also well below occupational exposure limits. However, we saw potential skin exposures to these chemicals. We provided recommendations on appropriate work practices and the selection and use of personal protective equipment. These recommendations were consistent with those derived using control banding tools for butylal. However, there is insufficient toxicological and health information to determine the safety of butylal in occupational settings. Independent evaluation of the toxicological properties of these alternative dry cleaning solvents, especially butylal, is urgently needed. JF - Journal of occupational and environmental hygiene AU - Ceballos, Diana M AU - Whittaker, Stephen G AU - Lee, Eun Gyung AU - Roberts, Jennifer AU - Streicher, Robert AU - Nourian, Fariba AU - Gong, Wei AU - Broadwater, Kendra AD - a Division of Surveillance, Hazard Evaluations, and Field Studies , National Institute for Occupational Safety and Health , Cincinnati , Ohio. ; b Local Hazardous Waste Management Program , Public Health-Seattle & King County , Seattle , Washington. ; c Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia. ; d Division of Applied Research & Technology , National Institute for Occupational Safety and Health , Cincinnati , Ohio. Y1 - 2016/10/02/ PY - 2016 DA - 2016 Oct 02 SP - 759 EP - 769 VL - 13 IS - 10 KW - Index Medicus KW - dibutoxymethane KW - high-flashpoint hydrocarbon KW - Alternative dry cleaning solvents KW - butylal KW - hydrocarbons KW - dry cleaning KW - formaldehyde KW - butanol UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812888836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Occupational+exposures+to+new+dry+cleaning+solvents%3A+High-flashpoint+hydrocarbons+and+butylal.&rft.au=Ceballos%2C+Diana+M%3BWhittaker%2C+Stephen+G%3BLee%2C+Eun+Gyung%3BRoberts%2C+Jennifer%3BStreicher%2C+Robert%3BNourian%2C+Fariba%3BGong%2C+Wei%3BBroadwater%2C+Kendra&rft.aulast=Ceballos&rft.aufirst=Diana&rft.date=2016-10-02&rft.volume=13&rft.issue=10&rft.spage=759&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2016.1177648 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2016.1177648 ER - TY - JOUR T1 - Use of auxiliary covariates in estimating a biomarker-adjusted treatment effect model with clinical trial data AN - 1830484150 AB - A biomarker-adjusted treatment effect (BATE) model describes the effect of one treatment versus another on a subpopulation of patients defined by a biomarker. Such a model can be estimated from clinical trial data without relying on additional modeling assumptions, and the estimator can be made more efficient by incorporating information on the main effect of the biomarker on the outcome of interest. Motivated by an HIV trial known as THRIVE, we consider the use of auxiliary covariates, which are usually available in clinical trials and have been used in overall treatment comparisons, in estimating a BATE model. Such covariates can be incorporated using an existing augmentation technique. For a specific type of estimating functions for difference-based BATE models, the optimal augmentation depends only on the joint main effects of marker and covariates. For a ratio-based BATE model, this result holds in special cases but not in general; however, simulation results suggest that the augmentation based on the joint main effects of marker and covariates is virtually equivalent to the theoretically optimal augmentation, especially when the augmentation terms are estimated from data. Application of these methods and results to the THRIVE data yields new insights on the utility of baseline CD4 cell count and viral load as predictive or treatment selection markers. JF - Statistical Methods in Medical Research AU - Zhang, Zhiwei AU - Qu, Yanping AU - Zhang, Bo AU - Nie, Lei AU - Soon, Guoxing AD - Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA ; Biostatistics Core, School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA ; Division of Biometrics IV, Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA ; Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 2103 EP - 2119 CY - London PB - Sage Publications Ltd. VL - 25 IS - 5 SN - 0962-2802 KW - Medical Sciences KW - conditional effect KW - interaction KW - personalized medicine KW - predictive biomarker KW - treatment effect heterogeneity KW - treatment selection KW - Biomarkers KW - Clinical trials KW - Augmentation KW - Immune response system KW - HIV KW - Simulation KW - Clinical research KW - Biological markers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1830484150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Use+of+auxiliary+covariates+in+estimating+a+biomarker-adjusted+treatment+effect+model+with+clinical+trial+data&rft.au=Zhang%2C+Zhiwei%3BQu%2C+Yanping%3BZhang%2C+Bo%3BNie%2C+Lei%3BSoon%2C+Guoxing&rft.aulast=Zhang&rft.aufirst=Zhiwei&rft.date=2016-10-01&rft.volume=25&rft.issue=5&rft.spage=2103&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213515572 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2013 N1 - Last updated - 2016-10-20 DO - http://dx.doi.org/10.1177/0962280213515572 ER - TY - JOUR T1 - New technology in electrophysiology: FDA process and perspective AN - 1827923894; PQ0003723213 AB - The Food and Drug Administration (FDA) is a large regulatory agency that monitors everything from food, tobacco, and veterinary medicine to pharmaceutical drugs and medical devices. The Mission statement of the CDRH, one of the Centers of the FDA, in its most succinct form is to protect and promote public health. This is accomplished through timely and continued access to safe, effective, and high quality medical devices. This paper aims to review the overarching principles of the Agency's review process for cardiac devices as well as highlight some of the newer programs that FDA has engaged in to facilitate innovation, device development, research, and timely market approval. JF - Journal of Interventional Cardiac Electrophysiology AU - Selzman, Kimberly A AU - Fellman, Mark AU - Farb, Andrew AU - de del Castillo, Sergio AU - Zuckerman, Bram AD - Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, 10903 New Hampshire Avenue, Implantable Electrophysiological Devices Branch, WO66, Silver Spring, MD, 20993, USA, kimberly.selzman@fda.hhs.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 11 EP - 18 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 47 IS - 1 SN - 1383-875X, 1383-875X KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Veterinary medicine KW - Reviews KW - Tobacco KW - Pharmaceuticals KW - Electrophysiology KW - Public health KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827923894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interventional+Cardiac+Electrophysiology&rft.atitle=New+technology+in+electrophysiology%3A+FDA+process+and+perspective&rft.au=Selzman%2C+Kimberly+A%3BFellman%2C+Mark%3BFarb%2C+Andrew%3Bde+del+Castillo%2C+Sergio%3BZuckerman%2C+Bram&rft.aulast=Selzman&rft.aufirst=Kimberly&rft.date=2016-10-01&rft.volume=47&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interventional+Cardiac+Electrophysiology&rft.issn=1383875X&rft_id=info:doi/10.1007%2Fs10840-016-0127-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Heart; Veterinary medicine; Reviews; Tobacco; Pharmaceuticals; Electrophysiology; Public health DO - http://dx.doi.org/10.1007/s10840-016-0127-4 ER - TY - JOUR T1 - Suicide Mortality Among Retired National Football League Players Who Played 5 or More Seasons AN - 1827909956; PQ0003722538 AB - Background: There is current disagreement in the scientific literature about the relationship between playing football and suicide risk, particularly among professional players in the National Football League (NFL). While some research indicates players are at high risk of football-related concussions, which may lead to chronic traumatic encephalopathy and suicide, other research finds such a connection to be speculative and unsupported by methodologically sound research. Purpose: To compare the suicide mortality of a cohort of NFL players to what would be expected in the general population of the United States. Study Design: Cohort study; Level of evidence, 3. Methods: A cohort of 3439 NFL players with at least 5 credited playing seasons between 1959 and 1988 was assembled for statistical analysis. The vital status for this cohort was updated through 2013. Standardized mortality ratios (SMRs), the ratio of observed deaths to expected deaths, and 95% CIs were computed for the cohort; 95% CIs that excluded unity were considered statistically significant. For internal comparison purposes, standardized rate ratios were calculated to compare mortality results between players stratified into speed and nonspeed position types. Results: Suicide among this cohort of professional football players was significantly less than would be expected in comparison with the United States population (SMR = 0.47; 95% CI, 0.24-0.82). There were no significant differences in suicide mortality between speed and nonspeed position players. Conclusion: There is no indication of elevated suicide risk in this cohort of professional football players with 5 or more credited seasons of play. Because of the unique nature of this cohort, these study results may not be applicable to professional football players who played fewer than 5 years or to college or high school players. JF - American Journal of Sports Medicine AU - Lehman, Everett J AU - Hein, Misty J AU - Gersic, Christine M AD - .National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio, USA, DYT1@cdc.gov Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 2486 EP - 2491 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 44 IS - 10 SN - 0363-5465, 0363-5465 KW - Physical Education Index KW - suicide KW - football KW - National Football League KW - concussion KW - Football (American KW - Athletes (professional) KW - Death KW - Research (statistical design) KW - Associations KW - Suicide KW - Football (American) KW - Professional sports KW - players) KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827909956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Drug+Interactions%3A+An+Evolution+in+Drug+Development&rft.au=Huang%2C+Shiew-Mei&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2016-10-01 N1 - Number of references - 36 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Athletes (professional); Football (American; Death; Research (statistical design); Associations; Football (American); Suicide; Professional sports; players) DO - http://dx.doi.org/10.1177/0363546516645093 ER - TY - JOUR T1 - Nontargeted, Rapid Screening of Extra Virgin Olive Oil Products for Authenticity Using Near-Infrared Spectroscopy in Combination with Conformity Index and Multivariate Statistical Analyses AN - 1827907365; PQ0003726249 AB - A rapid tool for evaluating authenticity was developed and applied to the screening of extra virgin olive oil (EVOO) retail products by using Fourier-transform near infrared (FT-NIR) spectroscopy in combination with univariate and multivariate data analysis methods. Using disposable glass tubes, spectra for 62 reference EVOO, 10 edible oil adulterants, 20 blends consisting of EVOO spiked with adulterants, 88 retail EVOO products and other test samples were rapidly measured in the transmission mode without any sample preparation. The univariate conformity index (CI) and the multivariate supervised soft independent modeling of class analogy (SIMCA) classification tool were used to analyze the various olive oil products which were tested for authenticity against a library of reference EVOO. Better discrimination between the authentic EVOO and some commercial EVOO products was observed with SIMCA than with CI analysis. Approximately 61% of all EVOO commercial products were flagged by SIMCA analysis, suggesting that further analysis be performed to identify quality issues and/or potential adulterants. Due to its simplicity and speed, FT-NIR spectroscopy in combination with multivariate data analysis can be used as a complementary tool to conventional official methods of analysis to rapidly flag EVOO products that may not belong to the class of authentic EVOO. JF - Journal of Food Science AU - Karunathilaka, Sanjeewa R AU - Kia, Ali-Reza Fardin AU - Srigley, Cynthia AU - Chung, Jin Kyu AU - Mossoba, Magdi M AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, Md, U.S.A. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - C2390 EP - C2397 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 81 IS - 10 SN - 0022-1147, 0022-1147 KW - Toxicology Abstracts; Environment Abstracts KW - I.R. radiation KW - Classification KW - I.R. spectroscopy KW - Statistical analysis KW - Fats and oils KW - Olive oil KW - Spectroscopy KW - Authenticity KW - X 24320:Food Additives & Contaminants KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827907365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Nontargeted%2C+Rapid+Screening+of+Extra+Virgin+Olive+Oil+Products+for+Authenticity+Using+Near-Infrared+Spectroscopy+in+Combination+with+Conformity+Index+and+Multivariate+Statistical+Analyses&rft.au=Sinha%2C+Vikram&rft.aulast=Sinha&rft.aufirst=Vikram&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - I.R. radiation; Classification; I.R. spectroscopy; Statistical analysis; Spectroscopy; Olive oil; Fats and oils; Authenticity DO - http://dx.doi.org/10.1111/1750-3841.13432 ER - TY - JOUR T1 - Outbreak Investigation of NADC30-Like PRRSV in South-East China AN - 1827907271; PQ0003650111 AB - Epidemiological outbreak investigations were conducted on NADC30-like porcine reproductive and respiratory syndrome virus (PRRSV) to investigate the prevalence of the disease in south-east China in 2015. Two more provinces were found to have NADC30-like PRRSV circulating besides previously reported six provinces. Phylogenetic analysis showed that these virus isolates were clustered in an independent branch and shared high nucleotide similarity to NADC30, a type 2 PRRSV that has been isolated in Unite States in 2008. One NADC30-like PRRSV strain from Henan province was successfully isolated on porcine alveolar macrophages and was tested on 6-week-old specific pathogen-free pigs for pathogenic study. The virus-inoculated pigs showed typical PRRSV clinical symptoms, but all pigs survived throughout the study with a period of 14 days. At necropsy, the lungs of infected pigs developed PRRSV-specific interstitial pneumonia, and virus antigen was detected in lung samples. Therefore, our results indicated NADC30-like PRRSV has widely spread in China and could cause clinical disease on pigs. JF - Transboundary and Emerging Diseases AU - Li, C AU - Zhuang, J AU - Wang, J AU - Han, L AU - Sun, Z AU - Xiao, Y AU - Ji, G AU - Li, Y AU - Tan, F AU - Li, X AU - Tian, K AD - National Research Center for Veterinary Medicine, Luoyang, China. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 474 EP - 479 PB - Wiley-Blackwell Verlag GmbH VL - 63 IS - 5 SN - 1865-1674, 1865-1674 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Phylogeny KW - Macrophages KW - Porcine respiratory and reproductive syndrome virus KW - Autopsy KW - Lung KW - Pneumonia KW - Alveoli KW - Nucleotides KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827907271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transboundary+and+Emerging+Diseases&rft.atitle=Outbreak+Investigation+of+NADC30-Like+PRRSV+in+South-East+China&rft.au=Li%2C+C%3BZhuang%2C+J%3BWang%2C+J%3BHan%2C+L%3BSun%2C+Z%3BXiao%2C+Y%3BJi%2C+G%3BLi%2C+Y%3BTan%2C+F%3BLi%2C+X%3BTian%2C+K&rft.aulast=Li&rft.aufirst=C&rft.date=2016-10-01&rft.volume=63&rft.issue=5&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Transboundary+and+Emerging+Diseases&rft.issn=18651674&rft_id=info:doi/10.1111%2Ftbed.12530 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Macrophages; Phylogeny; Autopsy; Lung; Nucleotides; Alveoli; Pneumonia; Porcine respiratory and reproductive syndrome virus DO - http://dx.doi.org/10.1111/tbed.12530 ER - TY - JOUR T1 - Mediterranean diet and mortality risk in metabolically healthy obese and metabolically unhealthy obese phenotypes AN - 1827894971; PQ0003725500 AB - Background: The Mediterranean diet has been consistently associated with reduced mortality risk. Few prospective studies have examined whether the benefits from a Mediterranean diet are equally shared by obese individuals with varying metabolic health. Objective: The objective of this study was to investigate the association between Mediterranean diet, metabolic phenotypes and mortality risk in a representative obese US population. Methods: Data from 1739 adults aged 20-88 years were analyzed from participants of the National Health and Nutrition Examination Survey III, 1988-1994 followed up for deaths until 31 December 2011 in a prospective cohort analysis. Mediterranean Diet Scores (MDS) were created to assess the adherence to Mediterranean diet. Participants were classified as metabolically healthy obese (MHO) phenotype (0 or 1 metabolic abnormality) or metabolically unhealthy obese (MUO) phenotype (two or more metabolic abnormalities), based on high glucose, insulin resistance, blood pressure, triglycerides, C-reactive protein and low high-density lipoprotein cholesterol. Results: The MHO phenotype (n=598) was observed in 34.8% (s.e., 1.7%) of those who were obese (mean body mass index was 33.4 and 34.8 in MHO and MUO phenotypes, respectively). During a median follow-up of 18.5 years, there were 77 (12.9%) and 309 (27.1%) deaths in MHO and MUO individuals, respectively. In MHO individuals, the multivariable-adjusted hazard ratio (HR) of all-cause mortality in the highest tertile compared with the first tertile of MDS was 0.44 (95% confidence interval (CI), 0.26-0.75; P for trend <0.001), after adjustment for potential confounders. A five-point (1 s.d.) increment in the adherence to MDS was associated with a 41% reduction in the risk of all-cause mortality (HR, 0.59; 95% CI, 0.37-0.94). Similar findings were obtained when we restricted our analyses to those with or without prevalent diabetes mellitus and hypertension. We did not observe mortality risk reduction in either individuals with MUO phenotype or all obese participants combined. Conclusions: Adherence to a Mediterranean dietary pattern appears to reduce mortality in the MHO phenotype, but not among the MUO phenotype in an obese population. JF - International Journal of Obesity AU - Park, Y-M AU - Steck, S E AU - Fung, T T AU - Zhang, J AU - Hazlett, L J AU - Han, K AU - Merchant, A T AD - Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1541 EP - 1549 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 40 IS - 10 SN - 0307-0565, 0307-0565 KW - Physical Education Index; Health & Safety Science Abstracts KW - Risk assessment KW - Death KW - Body mass KW - Lipids KW - Compliance KW - Glucose KW - Health KW - Risk reduction KW - Adults KW - Nutrition KW - Blood pressure KW - Insulin KW - Diets KW - Mortality KW - Obesity KW - Cholesterol KW - Diabetes mellitus KW - MED KW - Analysis KW - Proteins KW - Diet KW - Hypertension KW - H 12000:Epidemiology and Public Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827894971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Mediterranean+diet+and+mortality+risk+in+metabolically+healthy+obese+and+metabolically+unhealthy+obese+phenotypes&rft.au=Park%2C+Y-M%3BSteck%2C+S+E%3BFung%2C+T+T%3BZhang%2C+J%3BHazlett%2C+L+J%3BHan%2C+K%3BMerchant%2C+A+T&rft.aulast=Park&rft.aufirst=Y-M&rft.date=2016-10-01&rft.volume=40&rft.issue=10&rft.spage=1541&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fijo.2016.114 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Obesity; Death; Lipids; Analysis; Compliance; Health; Adults; Diet; Nutrition; Diets; Risk assessment; Mortality; Body mass; Glucose; Risk reduction; Cholesterol; Insulin; Blood pressure; Diabetes mellitus; Proteins; Hypertension; MED DO - http://dx.doi.org/10.1038/ijo.2016.114 ER - TY - GEN T1 - Corrigendum to 'The Janus faces of 3-hydroxykynurenine: Dual redox modulatory activity and lack of neurotoxicity in the rat striatum' [Brain Res. 1589 (2014) 1-14]. AN - 1826729398; 27450192 JF - Brain research AU - Colín-González, Ana Laura AU - Maya-López, Marisol AU - Pedraza-Chaverrí, José AU - Ali, Syed F AU - Chavarría, Anahí AU - Santamaría, Abel Y1 - 2016/10/01/ PY - 2016 DA - 2016 Oct 01 SP - 525 VL - 1648 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826729398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Brain+research&rft.atitle=Corrigendum+to+%27The+Janus+faces+of+3-hydroxykynurenine%3A+Dual+redox+modulatory+activity+and+lack+of+neurotoxicity+in+the+rat+striatum%27+%5BBrain+Res.+1589+%282014%29+1-14%5D.&rft.au=Col%C3%ADn-Gonz%C3%A1lez%2C+Ana+Laura%3BMaya-L%C3%B3pez%2C+Marisol%3BPedraza-Chaverr%C3%AD%2C+Jos%C3%A9%3BAli%2C+Syed+F%3BChavarr%C3%ADa%2C+Anah%C3%AD%3BSantamar%C3%ADa%2C+Abel&rft.aulast=Col%C3%ADn-Gonz%C3%A1lez&rft.aufirst=Ana&rft.date=2016-10-01&rft.volume=1648&rft.issue=&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2016.07.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.brainres.2016.07.004 ER - TY - JOUR T1 - Trastuzumab-Related Cardiotoxic Effects in Taiwanese Women: A Nationwide Cohort Study. AN - 1826701949; 27310478 AB - Importance Trastuzumab is an essential medicine per the World Health Organization Model List, but its cardiac safety information in Asian women is limited. Objective To estimate the rate and the risk of heart failure (HF) and/or cardiomyopathy (CM) in Asian women undergoing trastuzumab treatment. Design This cohort study used the Taiwanese National Health Insurance Research Database (NHIRD), a nationwide claim database covering more than 99% of the entire Taiwanese population, to identify 23 006 women with incident breast cancer (BC) who received chemotherapy from 2006 to 2009. We grouped women per their initial treatment regimens and found 1066 new trastuzumab users. We matched trastuzumab users with nonusers by year of BC diagnosis and propensity score (PS) with the caliper widths at 0.25 standard deviation of PS (up to 4 nonusers per trastuzumab user). The study lasted from January 2006 to December 2013 with a median follow-up of 5.29 years and a landmark design to avoid immortal time bias. Exposure Trastuzumab. Main Outcomes and Measures To estimate HF and/or CM rates and time to HF and/or CM, we employed a cause-specific hazard model. Trastuzumab exposure was a time-dependent variable, while cumulative courses of chemotherapy agents with known cardiotoxic effects (including anthracyclines, taxanes, and cyclophosphamide) were defined as time-dependent covariates in the analysis model. We also performed 6 sensitivity analyses. Results In this cohort of 23 006 women (mean age, 50.99 years), the crude incidence of HF and/or CM was 4.03% in trastuzumab users and 2.88% in nonusers. The median time to HF and/or CM was 456 days in trastuzumab users and 966 days in nonusers. The 1-year cumulative hazard ratio was 1.86 (95% CI, 1.08-3.19). The sensitivity analyses yielded similar results. Conclusions and Relevance Compared with the published results, the trastuzumab-related HF and/or CM rate was 5-fold lower in Taiwanese women with breast cancer. Nonetheless, our cohort had a similar trastuzumab-related HF and/or CM risk. Our study provides critical cardiac safety information of trastuzumab for Asian women with BC under current treatment guidelines and label information. JF - JAMA oncology AU - Chien, Hsu-Chih AU - Kao Yang, Yea-Huei AU - Bai, Jane P F AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland2Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan3Health Outcome Research Center, National Cheng Kung University, Tainan, Taiwan. ; Institute of Clinical Pharmacy and Pharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan3Health Outcome Research Center, National Cheng Kung University, Tainan, Taiwan. ; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland. Y1 - 2016/10/01/ PY - 2016 DA - 2016 Oct 01 SP - 1317 EP - 1325 VL - 2 IS - 10 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826701949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA+oncology&rft.atitle=Trastuzumab-Related+Cardiotoxic+Effects+in+Taiwanese+Women%3A+A+Nationwide+Cohort+Study.&rft.au=Chien%2C+Hsu-Chih%3BKao+Yang%2C+Yea-Huei%3BBai%2C+Jane+P+F&rft.aulast=Chien&rft.aufirst=Hsu-Chih&rft.date=2016-10-01&rft.volume=2&rft.issue=10&rft.spage=1317&rft.isbn=&rft.btitle=&rft.title=JAMA+oncology&rft.issn=2374-2445&rft_id=info:doi/10.1001%2Fjamaoncol.2016.1269 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-16 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1001/jamaoncol.2016.1269 ER - TY - JOUR T1 - Opportunities for social work under the Affordable Care Act: A call for action AN - 1825970871 AB - The Affordable Care Act (ACA) has profoundly restructured American health care. Numerous social work authors have commented on the importance of the ACA's reforms to social work practice, education, and research. This article summarizes the literature, adds relevant information, and makes recommendations for future actions. The policy, opinion, and peer-reviewed literatures were systematically reviewed. Sixty-three publications appeared between 2010 and 2015 are included. Five themes emerged, as follows: 1) the crucial provisions of the ACA, 2) the natural affinity of social work and the ACA reforms, 3) curricular adaptations needed to address changing workforce needs, 4) areas for continued social work advocacy, and 5) opportunities for high-impact social work research. This article provides a comprehensive introduction to the ACA, its reforms, and opportunities for social work to assume a high visibility leadership role in implementing the reforms, with particular emphasis on needed curricular changes and opportunities for research. JF - Social Work in Health Care AU - Lynch, Sean, PhD AU - Greeno, Catherine, PhD AU - Teich, Judith, PhD AU - Delany, Peter, PhD AD - Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA ; School of Social Work, University of Pittsburgh, Pittsburgh, Pennsylvania, USA ; Office of National Drug Control Policy, Washington, District of Columbia, USA ; Substance Abuse and Mental Health Services Administration, Rockville, Maryland, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 651 EP - 674 CY - New York PB - Taylor & Francis Ltd. VL - 55 IS - 9 SN - 0098-1389 KW - Social Services And Welfare KW - Affordable Care Act KW - health care reform KW - integrated care KW - policy KW - social work KW - social work practice KW - Health care policy KW - Patient Protection & Affordable Care Act 2010-US KW - Social work KW - Leadership KW - Health Care Services KW - Social Work Education KW - Social Work Research KW - Health Care Services Policy KW - Health care KW - Labour force KW - Professional practices KW - Publications KW - Professional training KW - Occupational health and safety KW - Advocacy KW - Reforms KW - Severely KW - Affinity KW - Visibility KW - 6140:illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825970871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Opportunities+for+social+work+under+the+Affordable+Care+Act%3A+A+call+for+action&rft.au=Lynch%2C+Sean%2C+PhD%3BGreeno%2C+Catherine%2C+PhD%3BTeich%2C+Judith%2C+PhD%3BDelany%2C+Peter%2C+PhD&rft.aulast=Lynch&rft.aufirst=Sean&rft.date=2016-10-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Social Services Abstracts N1 - Copyright - This article is not subject to U.S. copyright law. N1 - Last updated - 2017-01-06 DO - http://dx.doi.org/10.1080/00981389.2016.1221871 ER - TY - JOUR T1 - Causal inference with missing exposure information: Methods and applications to an obstetric study AN - 1825333867 AB - Causal inference in observational studies is frequently challenged by the occurrence of missing data, in addition to confounding. Motivated by the Consortium on Safe Labor, a large observational study of obstetric labor practice and birth outcomes, this article focuses on the problem of missing exposure information in a causal analysis of observational data. This problem can be approached from different angles (i.e. missing covariates and causal inference), and useful methods can be obtained by drawing upon the available techniques and insights in both areas. In this article, we describe and compare a collection of methods based on different modeling assumptions, under standard assumptions for missing data (i.e. missing-at-random and positivity) and for causal inference with complete data (i.e. no unmeasured confounding and another positivity assumption). These methods involve three models: one for treatment assignment, one for the dependence of outcome on treatment and covariates, and one for the missing data mechanism. In general, consistent estimation of causal quantities requires correct specification of at least two of the three models, although there may be some flexibility as to which two models need to be correct. Such flexibility is afforded by doubly robust estimators adapted from the missing covariates literature and the literature on causal inference with complete data, and by a newly developed triply robust estimator that is consistent if any two of the three models are correct. The methods are applied to the Consortium on Safe Labor data and compared in a simulation study mimicking the Consortium on Safe Labor. JF - Statistical Methods in Medical Research AU - Zhang, Zhiwei AU - Liu, Wei AU - Zhang, Bo AU - Tang, Li AU - Zhang, Jun AD - Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA ; Department of Mathematics, Harbin Institute of Technology, Harbin, P.R. China ; Biostatistics Core, School of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA ; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA ; MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China ; Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 2053 EP - 2066 CY - London PB - Sage Publications Ltd. VL - 25 IS - 5 SN - 0962-2802 KW - Medical Sciences KW - counterfactual KW - double robustness KW - inverse probability weighting KW - missing at random KW - missing covariate KW - propensity score KW - triple robustness KW - Obstetrics KW - Consortia KW - Regression analysis KW - Missing data KW - Observational research KW - Simulation KW - Specification KW - Flexibility KW - Positive affect KW - Childbirth KW - Estimators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825333867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Causal+inference+with+missing+exposure+information%3A+Methods+and+applications+to+an+obstetric+study&rft.au=Zhang%2C+Zhiwei%3BLiu%2C+Wei%3BZhang%2C+Bo%3BTang%2C+Li%3BZhang%2C+Jun&rft.aulast=Zhang&rft.aufirst=Zhiwei&rft.date=2016-10-01&rft.volume=25&rft.issue=5&rft.spage=2053&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213513758 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2013 N1 - Last updated - 2016-10-04 DO - http://dx.doi.org/10.1177/0962280213513758 ER - TY - JOUR T1 - Influence of Aspergillus fumigatus conidia viability on murine pulmonary microRNA and mRNA expression following subchronic inhalation exposure. AN - 1825217970; 27473664 AB - Personal exposure to fungal bioaerosols derived from contaminated building materials or agricultural commodities may induce or exacerbate a variety of adverse health effects. The genomic mechanisms that underlie pulmonary immune responses to fungal bioaerosols have remained unclear. The impact of fungal viability on the pulmonary microRNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia. Three groups of naïve B6C3F1/N mice were exposed via nose-only inhalation to A. fumigatus viable conidia, heat-inactivated conidia (HIC), or HEPA-filtered air twice a week for 13 weeks. Total RNA was isolated from whole lung 24 and 48 h postfinal exposure and was further processed for gene expression and microRNA array analysis. The molecular network pathways between viable and HIC groups were evaluated. Comparison of data sets revealed increased Il4, Il13 and Il33 expression in mice exposed to viable vs. HIC. Of 415 microRNAs detected, approximately 50% were altered in mice exposed to viable vs. HIC 48 h postexposure. Significantly down-regulated (P ≤ 0.05) miR-29a-3p was predicted to regulate TGF-β3 and Clec7a, genes involved in innate responses to viable A. fumigatus. Also significantly down-regulated (P ≤ 0.05), miR-23b-3p regulates genes involved in pulmonary IL-13 and IL-33 responses and SMAD2, downstream of TGF-β signalling. Using Ingenuity Pathway Analysis, a novel interaction was identified between viable conidia and SMAD2/3. Examination of the pulmonary genetic profiles revealed differentially expressed genes and microRNAs following subchronic inhalation exposure to A. fumigatus. MicroRNAs regulating genes involved in the pulmonary immune responses were those with the greatest fold change. Specifically, germinating A. fumigatus conidia were associated with Clec7a and were predicted to interact with Il13 and Il33. Furthermore, altered microRNAs may serve as potential biomarkers to evaluate fungal exposure. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology AU - Croston, T L AU - Nayak, A P AU - Lemons, A R AU - Goldsmith, W T AU - Gu, J K AU - Germolec, D R AU - Beezhold, D H AU - Green, B J AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. xzu9@cdc.gov. ; Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. ; Engineering and Control Technology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. ; Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. ; Toxicology Branch, DNTP/NIEHS, Research Triangle Park, NC, USA. ; Office of the Director, Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1315 EP - 1327 VL - 46 IS - 10 KW - Index Medicus KW - genetics KW - allergens and epitopes KW - animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825217970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+allergy+%3A+journal+of+the+British+Society+for+Allergy+and+Clinical+Immunology&rft.atitle=Influence+of+Aspergillus+fumigatus+conidia+viability+on+murine+pulmonary+microRNA+and+mRNA+expression+following+subchronic+inhalation+exposure.&rft.au=Croston%2C+T+L%3BNayak%2C+A+P%3BLemons%2C+A+R%3BGoldsmith%2C+W+T%3BGu%2C+J+K%3BGermolec%2C+D+R%3BBeezhold%2C+D+H%3BGreen%2C+B+J&rft.aulast=Croston&rft.aufirst=T&rft.date=2016-10-01&rft.volume=46&rft.issue=10&rft.spage=1315&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+allergy+%3A+journal+of+the+British+Society+for+Allergy+and+Clinical+Immunology&rft.issn=1365-2222&rft_id=info:doi/10.1111%2Fcea.12783 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/cea.12783 ER - TY - JOUR T1 - Potential Reuse of Oncology Drugs in the Treatment of Rare Diseases. AN - 1822117442; 27461952 AB - Cancer research has made remarkable progress with the help of advancing genomics techniques, resulting in more precise clinical application and many new anticancer drugs on the market. By contrast, very few treatment options are available for rare diseases that are often progressive, severe, and life-threatening. In this opinion we elaborate on the possible association between cancers and rare diseases across three different levels including clinical observation, crosstalk between germline mutation and somatic mutation, and shared biological pathways. Consequently, by utilizing systematic drug-repositioning approaches, and taking safety issues into consideration, we suggest that oncology drugs have great potential for reuse in the treatment of rare diseases. Published by Elsevier Ltd. JF - Trends in pharmacological sciences AU - Liu, Zhichao AU - Fang, Hong AU - Slikker, William AU - Tong, Weida AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Zhichao.liu@fda.hhs.gov. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: weida.tong@fda.hhs.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 843 EP - 857 VL - 37 IS - 10 KW - Index Medicus KW - genetic mutations KW - rare disease KW - oncology drugs KW - cancer KW - drug repositioning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1822117442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+pharmacological+sciences&rft.atitle=Potential+Reuse+of+Oncology+Drugs+in+the+Treatment+of+Rare+Diseases.&rft.au=Liu%2C+Zhichao%3BFang%2C+Hong%3BSlikker%2C+William%3BTong%2C+Weida&rft.aulast=Liu&rft.aufirst=Zhichao&rft.date=2016-10-01&rft.volume=37&rft.issue=10&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Trends+in+pharmacological+sciences&rft.issn=1873-3735&rft_id=info:doi/10.1016%2Fj.tips.2016.06.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tips.2016.06.010 ER - TY - JOUR T1 - Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients. AN - 1820594105; 27259059 AB - Sirolimus, an immunosuppressive agent used in renal transplantation, can prevent allograft rejection. Identification of the therapeutic index (the ratio of minimum toxic concentration to minimum therapeutic concentration) for immunosuppresants is necessary to optimize the care of patients and set standards for bioequivalence evaluation of sirolimus products. However, the therapeutic index for sirolimus has been inconsistently defined, potentially because of inconsistencies in sirolimus exposure-response relationships. The authors used retrospective therapeutic drug monitoring data from the electronic health records of patients treated in a tertiary health care system from 2008 to 2014 to (1) develop a population pharmacokinetic (PK) model, (2) use the model to simulate sirolimus concentrations, and (3) characterize the exposure-response relationship. Using Wilcoxon rank-sum and Fisher exact tests, the authors determined relationships between sirolimus exposure and adverse events (AEs) (anemia, leukopenia, thrombocytopenia, hyperlipidemia, and decline in renal function) and the composite efficacy end point of graft loss or rejection. The developed 2-compartment population PK model showed appropriate goodness of fit. In a late-phase (>12 months), postrenal transplant population of 27 inpatients, the authors identified statistically significant relationships between 83 simulated peak and trough sirolimus concentrations and outcomes: graft loss or rejection (P = 0.018) and decline in renal function (P = 0.006), respectively. Use of therapeutic drug monitoring results and PK modeling permitted correlation of sirolimus concentrations with graft loss or rejection and decline in renal function. However, the method was limited in its assessment of other AEs. To better evaluate sirolimus exposure-response relationships, the method should be applied to a larger sample of newly transplanted patients with a higher propensity toward AEs or efficacy failure. JF - Therapeutic drug monitoring AU - Zimmerman, Kanecia O AU - Wu, Huali AU - Greenberg, Rachel AU - Guptill, Jeffrey T AU - Hill, Kevin AU - Patel, Uptal D AU - Ku, Lawrence AU - Gonzalez, Daniel AU - Hornik, Christoph AU - Jiang, Wenlei AU - Zheng, Nan AU - Melloni, Chiara AU - Cohen-Wolkowiez, Michael AD - *Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina; Departments of †Pediatrics and ‡Medicine, Duke University School of Medicine, Durham, North Carolina; §Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina; and ¶Office of Generic Drugs, US Food and Drug Administration, Silver Spring, Maryland. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 600 EP - 606 VL - 38 IS - 5 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1820594105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+drug+monitoring&rft.atitle=Therapeutic+Drug+Monitoring%2C+Electronic+Health+Records%2C+and+Pharmacokinetic+Modeling+to+Evaluate+Sirolimus+Drug+Exposure-Response+Relationships+in+Renal+Transplant+Patients.&rft.au=Zimmerman%2C+Kanecia+O%3BWu%2C+Huali%3BGreenberg%2C+Rachel%3BGuptill%2C+Jeffrey+T%3BHill%2C+Kevin%3BPatel%2C+Uptal+D%3BKu%2C+Lawrence%3BGonzalez%2C+Daniel%3BHornik%2C+Christoph%3BJiang%2C+Wenlei%3BZheng%2C+Nan%3BMelloni%2C+Chiara%3BCohen-Wolkowiez%2C+Michael&rft.aulast=Zimmerman&rft.aufirst=Kanecia&rft.date=2016-10-01&rft.volume=38&rft.issue=5&rft.spage=600&rft.isbn=&rft.btitle=&rft.title=Therapeutic+drug+monitoring&rft.issn=1536-3694&rft_id=info:doi/10.1097%2FFTD.0000000000000313 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/FTD.0000000000000313 ER - TY - JOUR T1 - Structures of androgen receptor bound with ligands: advancing understanding of biological functions and drug discovery. AN - 1819905458; 27195510 AB - Androgen receptor (AR) is a ligand-dependent transcription factor and a member of the nuclear receptor superfamily. It plays a vital role in male sexual development and regulates gene expression in various tissues, including prostate. Androgens are compounds that exert their biological effects via interaction with AR. Binding of androgens to AR initiates conformational changes in AR that affect binding of co-regulator proteins and DNA. AR agonists and antagonists are widely used in a variety of clinical applications (i.e. hypogonadism and prostate cancer therapy). This review provides a close look at structures of AR-ligand complexes and mutations in the receptor that have been revealed, discusses current challenges in the field, and sheds light on future directions. AR is one of the primary targets for the treatment of prostate cancer, as AR antagonists inhibit prostate cancer growth. However, these drugs are not effective for long-term treatment and lead to castration-resistant prostate cancer. The structures of AR-ligand complexes are an invaluable scientific asset that enhances our understanding of biological functions and mechanisms of androgenic and anti-androgenic chemicals as well as promotes the discovery of superior drug candidates. JF - Expert opinion on therapeutic targets AU - Sakkiah, Sugunadevi AU - Ng, Hui Wen AU - Tong, Weida AU - Hong, Huixiao AD - a Division of Bioinformatics and Biostatistics , National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson , AR , USA. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1267 EP - 1282 VL - 20 IS - 10 KW - Index Medicus KW - Androgen receptor KW - testosterone KW - endocrine disruptors KW - dihydrotestosterone KW - endocrine receptor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819905458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+therapeutic+targets&rft.atitle=Structures+of+androgen+receptor+bound+with+ligands%3A+advancing+understanding+of+biological+functions+and+drug+discovery.&rft.au=Sakkiah%2C+Sugunadevi%3BNg%2C+Hui+Wen%3BTong%2C+Weida%3BHong%2C+Huixiao&rft.aulast=Sakkiah&rft.aufirst=Sugunadevi&rft.date=2016-10-01&rft.volume=20&rft.issue=10&rft.spage=1267&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+therapeutic+targets&rft.issn=1744-7631&rft_id=info:doi/10.1080%2F14728222.2016.1192131 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/14728222.2016.1192131 ER - TY - JOUR T1 - Diagnosis lost: Differences between children who had and who currently have an autism spectrum disorder diagnosis AN - 1817564956 AB - Autism spectrum disorder diagnoses sometimes change due to misdiagnosis, maturation, or treatment. This study uses a probability-based national survey--the Survey of Pathways to Diagnosis and Services--to compare currently diagnosed (n = 1420) and previously diagnosed (n = 187) children aged 6-17 years based on retrospective parental reports of early concerns about their children's development, responses to those concerns by doctors and other healthcare providers, the type of provider who made the first autism spectrum disorder diagnosis, and the autism spectrum disorder subtype diagnoses received (if any). Propensity score matching was used to control for differences between the groups on children's current level of functioning and other current characteristics that may have been related to diagnosis loss. Approximately 13% of the children ever diagnosed with autism spectrum disorder were estimated to have lost the diagnosis, and parents of 74% of them believed it was changed due to new information. Previously diagnosed children were less likely to have parents with early concerns about verbal skills, nonverbal communication, learning, and unusual gestures or movements. They were also less likely to have been referred to and diagnosed by a specialist. Previously diagnosed children were less likely to have ever received a diagnosis of Asperger's disorder or autistic disorder. JF - Autism AU - Blumberg, Stephen J AU - Zablotsky, Benjamin AU - Avila, Rosa M AU - Colpe, Lisa J AU - Pringle, Beverly A AU - Kogan, Michael D AD - Centers for Disease Control and Prevention, USA ; University of Washington, USA ; National Institutes of Health, USA ; Health Resources and Services Administration, USA ; Centers for Disease Control and Prevention, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 783 EP - 795 CY - London PB - SAGE PUBLICATIONS, INC. VL - 20 IS - 7 SN - 1362-3613 KW - Psychology KW - autism spectrum disorder KW - diagnosis KW - epidemiology KW - national surveys KW - Health care KW - Maturation KW - Autistic spectrum disorders KW - Misdiagnosis KW - Autistic children KW - National surveys KW - Doctors KW - Learning KW - Asperger's syndrome KW - Child development KW - Gestures KW - Nonverbal communication KW - Diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1817564956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autism&rft.atitle=Diagnosis+lost%3A+Differences+between+children+who+had+and+who+currently+have+an+autism+spectrum+disorder+diagnosis&rft.au=Blumberg%2C+Stephen+J%3BZablotsky%2C+Benjamin%3BAvila%2C+Rosa+M%3BColpe%2C+Lisa+J%3BPringle%2C+Beverly+A%3BKogan%2C+Michael+D&rft.aulast=Blumberg&rft.aufirst=Stephen&rft.date=2016-10-01&rft.volume=20&rft.issue=7&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Autism&rft.issn=13623613&rft_id=info:doi/10.1177%2F1362361315607724 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2015 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1177/1362361315607724 ER - TY - JOUR T1 - The Short-Term Effect of Depressive Symptoms on Labor Market Outcomes AN - 1816900612 AB - We estimated the short-term effects of symptoms of depression on labor market outcomes using data from the 2004-2009 Medical Expenditure Panel Survey. After accounting for the endogeneity of depression through a correlated random effects panel data specification, we found that exhibiting depressive symptoms reduces the likelihood of employment. We did not, however, find evidence of a causal relationship between depressive symptoms and hourly wages or weekly hours worked. Our estimates are substantially smaller than those from previous studies and imply that depressive symptoms reduce the contemporaneous probability of employment by 2.4 percentage points. In addition, we examined the effect of depression on work impairment and found that exhibiting depressive symptoms increases annual work loss days by about 1.4 days (33%), which implies that the annual aggregate productivity loses because of depression-induced absenteeism range from $900m to $1.9bn in 2009 USD. Copyright © 2015 John Wiley & Sons, Ltd. JF - Health Economics AU - Peng, Lizhong AU - Meyerhoefer, Chad D AU - Zuvekas, Samuel H AD - Health and Social Development Program, American Institutes for Research, Washington, DC, USA ; Department of Economics, Lehigh University, Bethlehem, PA, USA ; Center for Financing, Access and Cost Trends, U.S. Agency for Healthcare Research and Quality, Rockville, MD, USA ; Health and Social Development Program, American Institutes for Research, Washington, DC, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 1223 EP - 1238 CY - York PB - Wiley Subscription Services, Inc. VL - 25 IS - 10 SN - 1057-9230 KW - Business And Economics--Economic Situation And Conditions KW - Productivity KW - Short term KW - Labour market KW - Depression KW - Random effects KW - Labour KW - Specification KW - Absenteeism KW - Panel data KW - Employment KW - Working hours KW - Expenditure KW - Wages KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816900612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=The+Short-Term+Effect+of+Depressive+Symptoms+on+Labor+Market+Outcomes&rft.au=Peng%2C+Lizhong%3BMeyerhoefer%2C+Chad+D%3BZuvekas%2C+Samuel+H&rft.aulast=Peng&rft.aufirst=Lizhong&rft.date=2016-10-01&rft.volume=25&rft.issue=10&rft.spage=1223&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.3224 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © 2016 John Wiley & Sons, Ltd. N1 - Last updated - 2016-09-07 DO - http://dx.doi.org/10.1002/hec.3224 ER - TY - JOUR T1 - Metabolomics evaluation of the impact of smokeless tobacco exposure on the oral bacterium Capnocytophaga sputigena. AN - 1816864281; 27480511 AB - The association between exposure to smokeless tobacco products (STP) and oral diseases is partially due to the physiological and pathological changes in the composition of the oral microbiome and its metabolic profile. However, it is not clear how STPs affect the physiology and ecology of oral microbiota. A UPLC/QTof-MS-based metabolomics study was employed to analyze metabolic alterations in oral bacterium, Capnocytophaga sputigena as a result of smokeless tobacco exposure and to assess the capability of the bacterium to metabolize nicotine. Pathway analysis of the metabolome profiles indicated that smokeless tobacco extracts caused oxidative stress in the bacterium. The metabolomics data also showed that the arginine-nitric oxide pathway was perturbed by the smokeless tobacco treatment. Results also showed that LC/MS was useful in identifying STP constituents and additives, including caffeine and many flavoring compounds. No significant changes in levels of nicotine and its major metabolites were found when C. sputigena was cultured in a nutrient rich medium, although hydroxylnicotine and cotinine N-oxide were detected in the bacterial metabolites suggesting that nicotine metabolism might be present as a minor degradation pathway in the bacterium. Study results provide new insights regarding the physiological and toxicological effects of smokeless tobacco on oral bacterium C. sputigena and associated oral health as well as measuring the ability of the oral bacterium to metabolize nicotine. Published by Elsevier Ltd. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Sun, Jinchun AU - Jin, Jinshan AU - Beger, Richard D AU - Cerniglia, Carl E AU - Yang, Maocheng AU - Chen, Huizhong AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd, Jefferson, AR 72079, United States. Electronic address: Jinchun.Sun@fda.hhs.gov. ; Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd, Jefferson, AR 72079, United States. ; Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd, Jefferson, AR 72079, United States. ; Office of Science, Center for Tobacco Products, US FDA, 10903 New Hampshire Ave, Silver Spring, MD 20993, United States. Electronic address: Maocheng.Yang@fda.hhs.gov. ; Division of Microbiology, National Center for Toxicological Research, US FDA, 3900 NCTR Rd, Jefferson, AR 72079, United States. Electronic address: Huizhong.Chen@fda.hhs.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 133 EP - 141 VL - 36 KW - Index Medicus KW - Smokeless tobacco KW - Oral bacteria KW - Toxicology KW - Metabolomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816864281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Metabolomics+evaluation+of+the+impact+of+smokeless+tobacco+exposure+on+the+oral+bacterium+Capnocytophaga+sputigena.&rft.au=Sun%2C+Jinchun%3BJin%2C+Jinshan%3BBeger%2C+Richard+D%3BCerniglia%2C+Carl+E%3BYang%2C+Maocheng%3BChen%2C+Huizhong&rft.aulast=Sun&rft.aufirst=Jinchun&rft.date=2016-10-01&rft.volume=36&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2016.07.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2016.07.020 ER - TY - JOUR T1 - Regulatory bioinformatics for food and drug safety. AN - 1816638572; 27208439 AB - "Regulatory Bioinformatics" strives to develop and implement a standardized and transparent bioinformatic framework to support the implementation of existing and emerging technologies in regulatory decision-making. It has great potential to improve public health through the development and use of clinically important medical products and tools to manage the safety of the food supply. However, the application of regulatory bioinformatics also poses new challenges and requires new knowledge and skill sets. In the latest Global Coalition on Regulatory Science Research (GCRSR) governed conference, Global Summit on Regulatory Science (GSRS2015), regulatory bioinformatics principles were presented with respect to global trends, initiatives and case studies. The discussion revealed that datasets, analytical tools, skills and expertise are rapidly developing, in many cases via large international collaborative consortia. It also revealed that significant research is still required to realize the potential applications of regulatory bioinformatics. While there is significant excitement in the possibilities offered by precision medicine to enhance treatments of serious and/or complex diseases, there is a clear need for further development of mechanisms to securely store, curate and share data, integrate databases, and standardized quality control and data analysis procedures. A greater understanding of the biological significance of the data is also required to fully exploit vast datasets that are becoming available. The application of bioinformatics in the microbiological risk analysis paradigm is delivering clear benefits both for the investigation of food borne pathogens and for decision making on clinically important treatments. It is recognized that regulatory bioinformatics will have many beneficial applications by ensuring high quality data, validated tools and standardized processes, which will help inform the regulatory science community of the requirements necessary to ensure the safe introduction and effective use of these applications. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Healy, Marion J AU - Tong, Weida AU - Ostroff, Stephen AU - Eichler, Hans-Georg AU - Patak, Alex AU - Neuspiel, Margaret AU - Deluyker, Hubert AU - Slikker, William AD - Food Standards Australia New Zealand, Barton, Australian Capital Territory, 2905, Australia. Electronic address: marion.healy@foodstandards.gov.au. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079-9502, USA. Electronic address: weida.tong@fda.hhs.gov. ; US Food and Drug Administration, Silver Spring, MD, 20993-0002, USA. Electronic address: stephen.ostroff@fda.hhs.gov. ; European Medicines Agency, London, E14 5EU, United Kingdom. Electronic address: hans-georg.eichler@ema.europa.eu. ; European Commission, Joint Research Centre, Ispra, Varese, 21027, Italy. Electronic address: alex.patak@ec.europa.eu. ; Canadian Food Inspection Agency, Ottawa, Ontario, Canada. Electronic address: margaret.neuspiel@inspection.gc.ca. ; European Food Safety Authority, Parma, 43126, Italy. Electronic address: Hubert.deluyker@efsa.europa.eu. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079-9502, USA. Electronic address: william.slikker@fda.hhs.gov. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 342 EP - 347 VL - 80 KW - Index Medicus KW - Regulatory science KW - GSRS KW - Microbiome KW - GCRSR KW - Food safety KW - Regulatory bioinformatics KW - Bioinformatics KW - Next-generation sequencing KW - Genomics KW - Drug safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816638572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Regulatory+bioinformatics+for+food+and+drug+safety.&rft.au=Healy%2C+Marion+J%3BTong%2C+Weida%3BOstroff%2C+Stephen%3BEichler%2C+Hans-Georg%3BPatak%2C+Alex%3BNeuspiel%2C+Margaret%3BDeluyker%2C+Hubert%3BSlikker%2C+William&rft.aulast=Healy&rft.aufirst=Marion&rft.date=2016-10-01&rft.volume=80&rft.issue=&rft.spage=342&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.05.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.05.021 ER - TY - JOUR T1 - A biokinetic model for nickel released from cardiovascular devices. AN - 1816637708; 27208438 AB - Many alloys used in cardiovascular device applications contain high levels of nickel, which if released in sufficient quantities, can lead to adverse health effects. While nickel release from these devices is typically characterized through the use of in-vitro immersion tests, it is unclear if the rate at which nickel is released from a device during in-vitro testing is representative of the release rate following implantation in the body. To address this uncertainty, we have developed a novel biokinetic model that combines a traditional toxicokinetic compartment model with a physics-based model to estimate nickel release from an implanted device. This model links the rate of in-vitro nickel release from a cardiovascular device to serum nickel concentrations, an easily measured endpoint, to estimate the rate and extent of in-vivo nickel release from an implanted device. The model was initially parameterized using data in the literature on in-vitro nickel release from a nickel-containing alloy (nitinol) and baseline serum nickel levels in humans. The results of this first step were then used to validate specific components of the model. The remaining unknown quantities were fit using serum values reported in patients following implantation with nitinol atrial occluder devices. The model is not only consistent with levels of nickel in serum and urine of patients following treatment with the atrial occluders, but also the optimized parameters in the model were all physiologically plausible. The congruity of the model with available data suggests that it can provide a framework to interpret nickel biomonitoring data and use data from in-vitro nickel immersion tests to estimate in-vivo nickel release from implanted cardiovascular devices. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Saylor, David M AU - Adidharma, Lingga AU - Fisher, Jeffrey W AU - Brown, Ronald P AD - Center for Devices and Radiological Health, FDA, Silver Spring, MD 20993, USA. Electronic address: david.saylor@fda.hhs.gov. ; Center for Devices and Radiological Health, FDA, Silver Spring, MD 20993, USA. ; National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 1 EP - 8 VL - 80 KW - Index Medicus KW - Compartment model KW - Nickel release KW - Biomonitoring KW - Nitinol KW - Diffusion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816637708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=A+biokinetic+model+for+nickel+released+from+cardiovascular+devices.&rft.au=Saylor%2C+David+M%3BAdidharma%2C+Lingga%3BFisher%2C+Jeffrey+W%3BBrown%2C+Ronald+P&rft.aulast=Saylor&rft.aufirst=David&rft.date=2016-10-01&rft.volume=80&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.05.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.05.019 ER - TY - JOUR T1 - Parental investment responses to a low birth weight outcome: who compensates and who reinforces? AN - 1811885882; PQ0003517755 AB - This study analyzes how parental investment responds to a low birth weight (LBW) outcome and finds important differences in investment responses by maternal education. High school dropouts reinforce a LBW outcome by providing less investment in the human capital of their LBW children relative to their normal birth weight children whereas higher educated mothers compensate by investing more in their LBW children. In addition, an increase in the number of LBW siblings present in the home raises investment in a child, which is consistent with reinforcement, but this positive effect tends to be concentrated among high school dropouts. These results suggest that studies analyzing the effects of LBW on child outcomes that do not account for heterogeneity in investment responses to a LBW outcome by maternal education may overestimate effects of LBW on child outcomes for those born to low-educated mothers and underestimate such effects for those born to high-educated mothers. JF - Journal of Population Economics AU - Restrepo, Brandon J AD - Office of the Commissioner, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA, brandon.restrepo@eui.eu Y1 - 2016/10// PY - 2016 DA - October 2016 SP - 969 EP - 989 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 29 IS - 4 SN - 0933-1433, 0933-1433 KW - Environment Abstracts KW - Birth weight KW - Human capital KW - Low-birth-weight KW - Schools KW - Economics KW - Siblings KW - Children KW - ENA 04:Environmental Education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811885882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Population+Economics&rft.atitle=Parental+investment+responses+to+a+low+birth+weight+outcome%3A+who+compensates+and+who+reinforces%3F&rft.au=Restrepo%2C+Brandon+J&rft.aulast=Restrepo&rft.aufirst=Brandon&rft.date=2016-10-01&rft.volume=29&rft.issue=4&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=Journal+of+Population+Economics&rft.issn=09331433&rft_id=info:doi/10.1007%2Fs00148-016-0590-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 57 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Birth weight; Human capital; Schools; Low-birth-weight; Economics; Siblings; Children DO - http://dx.doi.org/10.1007/s00148-016-0590-3 ER - TY - JOUR T1 - Latent Tuberculosis Infection Among Immigrant and Refugee Children Arriving in the United States: 2010 AN - 1811041183 AB - Immigrants and refugees age 2-14 years entering the United States from countries with estimated tuberculosis (TB) incidence rate [greater than or equal to]20 per 100,000 population are screened for TB. Children with TB disease are treated before US arrival. Children with positive tuberculin skin tests (TST), but negative TB evaluation during their pre-immigration examination, are classified with latent TB infection (LTBI) and are recommended for re-evaluation post-arrival. We examined post-immigration TB evaluation and therapy for children arriving with LTBI. We reviewed medical exam data from immigrant children with medical conditions and all refugee children arriving during 2010. Medical examination data were available for 67,334 children. Of these, 8231 (12 %) had LTBI pre-immigration; 5749 (70 %) were re-evaluated for TB post-immigration, and 64 % were retested by TST or IGRA. The pre-immigration LTBI diagnosis was changed for 38 % when retested by TST and for 71 % retested by IGRA. Estimated LTBI therapy initiation and completion rates were 68 and 12 %. In this population, testing with IGRA may limit the number of children targeted for therapy. Increased pre-immigration TB screening with post-immigration follow-up evaluation leading to completion of LTBI therapy should be encouraged to prevent TB reactivation. JF - Journal of Immigrant and Minority Health AU - Taylor, Eboni M AU - Painter, John AU - Posey, Drew L AU - Zhou, Weigong AU - Shetty, Sharmila AD - Division of Global Migration and Quarantine, National Center of Emerging Zoonotic and Infectious Diseases, United States Centers for Disease Control and Prevention, Mailstop E-04, Atlanta, GA, USA; United States Public Health Service Commissioned Corps, Washington, DC, USA ; Division of Global Migration and Quarantine, National Center of Emerging Zoonotic and Infectious Diseases, United States Centers for Disease Control and Prevention, Mailstop E-04, Atlanta, GA, USA; United States Public Health Service Commissioned Corps, Washington, DC, USA Y1 - 2016/10// PY - 2016 DA - Oct 2016 SP - 966 EP - 970 CY - New York PB - Springer Science & Business Media VL - 18 IS - 5 SN - 1557-1912 KW - Medical Sciences KW - Pediatric KW - Tuberculin skin test KW - Interferon gamma release assay KW - Migrants KW - Infection KW - Screening KW - Medical conditions KW - Tuberculosis KW - Immigration KW - Children KW - Diagnosis KW - Refugees KW - Immigrants KW - Initiation KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811041183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Latent+Tuberculosis+Infection+Among+Immigrant+and+Refugee+Children+Arriving+in+the+United+States%3A+2010&rft.au=Taylor%2C+Eboni+M%3BPainter%2C+John%3BPosey%2C+Drew+L%3BZhou%2C+Weigong%3BShetty%2C+Sharmila&rft.aulast=Taylor&rft.aufirst=Eboni&rft.date=2016-10-01&rft.volume=18&rft.issue=5&rft.spage=966&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-015-0273-2 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1007/s10903-015-0273-2 ER - TY - JOUR T1 - Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations. AN - 1859739552; 27650663 AB - For several decades, regulatory testing schemes for genetic damage have been standardized where the tests being utilized examined mutations and structural and numerical chromosomal damage. This has served the genetic toxicity community well when most of the substances being tested were amenable to such assays. The outcome from this testing is usually a dichotomous (yes/no) evaluation of test results, and in many instances, the information is only used to determine whether a substance has carcinogenic potential or not. Over the same time period, mechanisms and modes of action (MOAs) that elucidate a wider range of genomic damage involved in many adverse health outcomes have been recognized. In addition, a paradigm shift in applied genetic toxicology is moving the field toward a more quantitative dose-response analysis and point-of-departure (PoD) determination with a focus on risks to exposed humans. This is directing emphasis on genomic damage that is likely to induce changes associated with a variety of adverse health outcomes. This paradigm shift is moving the testing emphasis for genetic damage from a hazard identification only evaluation to a more comprehensive risk assessment approach that provides more insightful information for decision makers regarding the potential risk of genetic damage to exposed humans. To enable this broader context for examining genetic damage, a next generation testing strategy needs to take into account a broader, more flexible approach to testing, and ultimately modeling, of genomic damage as it relates to human exposure. This is consistent with the larger risk assessment context being used in regulatory decision making. As presented here, this flexible approach for examining genomic damage focuses on testing for relevant genomic effects that can be, as best as possible, associated with an adverse health effect. The most desired linkage for risk to humans would be changes in loci associated with human diseases, whether in somatic or germ cells. The outline of a flexible approach and associated considerations are presented in a series of nine steps, some of which can occur in parallel, which was developed through a collaborative effort by leading genetic toxicologists from academia, government, and industry through the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) Genetic Toxicology Technical Committee (GTTC). The ultimate goal is to provide quantitative data to model the potential risk levels of substances, which induce genomic damage contributing to human adverse health outcomes. Any good risk assessment begins with asking the appropriate risk management questions in a planning and scoping effort. This step sets up the problem to be addressed (e.g., broadly, does genomic damage need to be addressed, and if so, how to proceed). The next two steps assemble what is known about the problem by building a knowledge base about the substance of concern and developing a rational biological argument for why testing for genomic damage is needed or not. By focusing on the risk management problem and potential genomic damage of concern, the next step of assay(s) selection takes place. The work-up of the problem during the earlier steps provides the insight to which assays would most likely produce the most meaningful data. This discussion does not detail the wide range of genomic damage tests available, but points to types of testing systems that can be very useful. Once the assays are performed and analyzed, the relevant data sets are selected for modeling potential risk. From this point on, the data are evaluated and modeled as they are for any other toxicology endpoint. Any observed genomic damage/effects (or genetic event(s)) can be modeled via a dose-response analysis and determination of an estimated PoD. When a quantitative risk analysis is needed for decision making, a parallel exposure assessment effort is performed (exposure assessment is not detailed here as this is not the focus of this discussion; guidelines for this assessment exist elsewhere). Then the PoD for genomic damage is used with the exposure information to develop risk estimations (e.g., using reference dose (RfD), margin of exposure (MOE) approaches) in a risk characterization and presented to risk managers for informing decision making. This approach is applicable now for incorporating genomic damage results into the decision-making process for assessing potential adverse outcomes in chemically exposed humans and is consistent with the ILSI HESI Risk Assessment in the 21st Century (RISK21) roadmap. This applies to any substance to which humans are exposed, including pharmaceuticals, agricultural products, food additives, and other chemicals. It is time for regulatory bodies to incorporate the broader knowledge and insights provided by genomic damage results into the assessments of risk to more fully understand the potential of adverse outcomes in chemically exposed humans, thus improving the assessment of risk due to genomic damage. The historical use of genomic damage data as a yes/no gateway for possible cancer risk has been too narrowly focused in risk assessment. The recent advances in assaying for and understanding genomic damage, including eventually epigenetic alterations, obviously add a greater wealth of information for determining potential risk to humans. Regulatory bodies need to embrace this paradigm shift from hazard identification to quantitative analysis and to incorporate the wider range of genomic damage in their assessments of risk to humans. The quantitative analyses and methodologies discussed here can be readily applied to genomic damage testing results now. Indeed, with the passage of the recent update to the Toxic Substances Control Act (TSCA) in the US, the new generation testing strategy for genomic damage described here provides a regulatory agency (here the US Environmental Protection Agency (EPA), but suitable for others) a golden opportunity to reexamine the way it addresses risk-based genomic damage testing (including hazard identification and exposure). Environ. Mol. Mutagen., 2016. © 2016 The Authors. Environmental and Molecular Mutagenesis Published by Wiley Periodicals, Inc. © 2016 The Authors. Environmental and Molecular Mutagenesis Published by Wiley Periodicals, Inc. JF - Environmental and molecular mutagenesis AU - Dearfield, Kerry L AU - Gollapudi, B Bhaskar AU - Bemis, Jeffrey C AU - Benz, R Daniel AU - Douglas, George R AU - Elespuru, Rosalie K AU - Johnson, George E AU - Kirkland, David J AU - LeBaron, Matthew J AU - Li, Albert P AU - Marchetti, Francesco AU - Pottenger, Lynn H AU - Rorije, Emiel AU - Tanir, Jennifer Y AU - Thybaud, Veronique AU - van Benthem, Jan AU - Yauk, Carole L AU - Zeiger, Errol AU - Luijten, Mirjam AD - U.S. Department of Agriculture, Food Safety and Inspection Service, Washington, District of Columbia. ; Exponent® Inc, Center for Toxicology and Mechanistic Biology, Midland, Michigan. ; Litron Laboratories, Rochester, New York. ; OmnyCorp, Rockville, Maryland. ; Environmental Health Science and Research Bureau, Health Canada, Ottawa, ON, K1A 0K9, Canada. ; U.S. Food and Drug Administration, CDRH/OSEL DBCMS, Silver Spring, Maryland. ; Institute of Life Science, College of Medicine, Swansea University, Swansea, SA2 8PP, United Kingdom. ; Kirkland Consulting, Tadcaster, LS24 OAS, United Kingdom. ; The Dow Chemical Company, Molecular, Cellular, and Biochemical Toxicology, Midland, Michigan. ; In Vitro ADMET Laboratories LLC, Columbia, Maryland. ; Formerly of The Dow Chemical Company, Toxicology & Environmental Research and Consulting now with Olin Corporation, Midland, Michigan. ; National Institute for Public Health and the Environment (RIVM), Center for Safety of Substances and Products, Bilthoven, 3720 BA, The Netherlands. ; ILSI Health and Environmental Sciences Institute (HESI), Washington, District of Columbia. jtanir@hesiglobal.org. ; Sanofi, Drug Disposition, Safety and Animal Research, Vitry-sur-Seine, France. ; National Institute for Public Health and the Environment (RIVM), Center for Health Protection, Bilthoven, 3720 BA, The Netherlands. ; Errol Zeiger Consulting, Chapel Hill, North Carolina. Y1 - 2016/09/21/ PY - 2016 DA - 2016 Sep 21 KW - integrated testing strategy KW - exposure assessment KW - genetic toxicology KW - risk assessment KW - mutagenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859739552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Next+generation+testing+strategy+for+assessment+of+genomic+damage%3A+A+conceptual+framework+and+considerations.&rft.au=Dearfield%2C+Kerry+L%3BGollapudi%2C+B+Bhaskar%3BBemis%2C+Jeffrey+C%3BBenz%2C+R+Daniel%3BDouglas%2C+George+R%3BElespuru%2C+Rosalie+K%3BJohnson%2C+George+E%3BKirkland%2C+David+J%3BLeBaron%2C+Matthew+J%3BLi%2C+Albert+P%3BMarchetti%2C+Francesco%3BPottenger%2C+Lynn+H%3BRorije%2C+Emiel%3BTanir%2C+Jennifer+Y%3BThybaud%2C+Veronique%3Bvan+Benthem%2C+Jan%3BYauk%2C+Carole+L%3BZeiger%2C+Errol%3BLuijten%2C+Mirjam&rft.aulast=Dearfield&rft.aufirst=Kerry&rft.date=2016-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.22045 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/em.22045 ER - TY - JOUR T1 - Differential Activation of a Mouse Estrogen Receptor β Isoform (mERβ2) with Endocrine-Disrupting Chemicals (EDCs). AN - 1859740562; 27634370 AB - Endocrine disrupting compounds (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects have been reported in animal studies and extrapolated to human studies. Unlike humans, rodents express a novel isoform of ERβ (mERβ2) with a modified ligand binding domain sequence. EDC activity through this isoform remains uncharacterized. We identified the expression pattern of mERβ2 in mouse tissues and assessed the estrogenic activity of EDCs through mERβ2. mERβ2 mRNA expression was measured in mouse tissues. HepG2 cells were used to assess the transactivation activity of mERβ isoforms with EDCs and ER coactivators. 293A cells transiently transfected with mER isoforms were used to detect EDC-mediated changes in endogenous ER target gene expression. Expression of mERβ2 mRNA was detected in mouse reproductive tissues (ovary, testis, and prostate) and lung and colon tissues from both female and male mice. Five (E2, DES, DPN, BPAF, Coum, 1-BP) of sixteen compounds tested by reporter assay had estrogenic activity through mERβ2. mERβ2 had a compound-specifc negative effect on ERβ/ligand-mediated activity and ER target genes when co-expressed with mERβ1. mERβ2 recruited coactivators SRC2 or SRC3 in the presence of EDCs, but showed less recruitment than mERβ1. mERβ2 showed weaker estrogenic activity than mERβ1 in our in vitro system, and can dampen mERβ1 activity. In vivo models of EDC activity and ER-mediated toxicity should consider the role of mERβ2, as rodent tissue responses involving mERβ2 may not be reproduced in human biology. JF - Environmental health perspectives AU - Donoghue, Lauren J AU - Neufeld, Thomas I AU - Li, Yin AU - Arao, Yukitomo AU - Coons, Laurel A AU - Korach, Kenneth S AD - Receptor Biology Section, Reproductive and Developmental Biology Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/09/16/ PY - 2016 DA - 2016 Sep 16 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859740562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Differential+Activation+of+a+Mouse+Estrogen+Receptor+%CE%B2+Isoform+%28mER%CE%B22%29+with+Endocrine-Disrupting+Chemicals+%28EDCs%29.&rft.au=Donoghue%2C+Lauren+J%3BNeufeld%2C+Thomas+I%3BLi%2C+Yin%3BArao%2C+Yukitomo%3BCoons%2C+Laurel+A%3BKorach%2C+Kenneth+S&rft.aulast=Donoghue&rft.aufirst=Lauren&rft.date=2016-09-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Development of a PBPK model of thiocyanate in rats with an extrapolation to humans: A computational study to quantify the mechanism of action of thiocyanate kinetics in thyroid. AN - 1814144235; 27445130 AB - Thyroid homeostasis can be disturbed due to thiocyanate exposure from the diet or tobacco smoke. Thiocyanate inhibits both thyroidal uptake of iodide, via the sodium-iodide symporter (NIS), and thyroid hormone (TH) synthesis in the thyroid, via thyroid peroxidase (TPO), but the mode of action of thiocyanate is poorly quantified in the literature. The characterization of the link between intra-thyroidal thiocyanate concentrations and dose of exposure is crucial for assessing the risk of thyroid perturbations due to thiocyanate exposure. We developed a PBPK model for thiocyanate that describes its kinetics in the whole-body up to daily doses of 0.15mmol/kg, with a mechanistic description of the thyroidal kinetics including NIS, passive diffusion, and TPO. The model was calibrated in a Bayesian framework using published studies in rats. Goodness-of-fit was satisfactory, especially for intra-thyroidal thiocyanate concentrations. Thiocyanate kinetic processes were quantified in vivo, including the metabolic clearance by TPO. The passive diffusion rate was found to be greater than NIS-mediated uptake rate. The model captured the dose-dependent kinetics of thiocyanate after acute and chronic exposures. Model behavior was evaluated using a Morris screening test. The distribution of thiocyanate into the thyroid was found to be determined primarily by the partition coefficient, followed by NIS and passive diffusion; the impact of the latter two mechanisms appears to increase at very low doses. Extrapolation to humans resulted in good predictions of thiocyanate kinetics during chronic exposure. The developed PBPK model can be used in risk assessment to quantify dose-response effects of thiocyanate on TH. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Willemin, Marie-Emilie AU - Lumen, Annie AD - Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Annie.Lumen@fda.hhs.gov. Y1 - 2016/09/15/ PY - 2016 DA - 2016 Sep 15 SP - 19 EP - 34 VL - 307 KW - Index Medicus KW - Bayesian KW - Thyroid KW - TPO KW - PBPK model KW - Thiocyanate KW - NIS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814144235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Development+of+a+PBPK+model+of+thiocyanate+in+rats+with+an+extrapolation+to+humans%3A+A+computational+study+to+quantify+the+mechanism+of+action+of+thiocyanate+kinetics+in+thyroid.&rft.au=Willemin%2C+Marie-Emilie%3BLumen%2C+Annie&rft.aulast=Willemin&rft.aufirst=Marie-Emilie&rft.date=2016-09-15&rft.volume=307&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.07.011 ER - TY - JOUR T1 - Acetazolamide Mitigates Astrocyte Cellular Edema Following Mild Traumatic Brain Injury. AN - 1819904076; 27623738 AB - Non-penetrating or mild traumatic brain injury (mTBI) is commonly experienced in accidents, the battlefield and in full-contact sports. Astrocyte cellular edema is one of the major factors that leads to high morbidity post-mTBI. Various studies have reported an upregulation of aquaporin-4 (AQP4), a water channel protein, following brain injury. AZA is an antiepileptic drug that has been shown to inhibit AQP4 expression and in this study we investigate the drug as a therapeutic to mitigate the extent of mTBI induced cellular edema. We hypothesized that mTBI-mediated astrocyte dysfunction, initiated by increased intracellular volume, could be reduced when treated with AZA. We tested our hypothesis in a three-dimensional in vitro astrocyte model of mTBI. Samples were subject to no stretch (control) or one high-speed stretch (mTBI) injury. AQP4 expression was significantly increased 24 hours after mTBI. mTBI resulted in a significant increase in the cell swelling within 30 min of mTBI, which was significantly reduced in the presence of AZA. Cell death and expression of S100B was significantly reduced when AZA was added shortly before mTBI stretch. Overall, our data point to occurrence of astrocyte swelling immediately following mTBI, and AZA as a promising treatment to mitigate downstream cellular mortality. JF - Scientific reports AU - Sturdivant, Nasya M AU - Smith, Sean G AU - Ali, Syed F AU - Wolchok, Jeffrey C AU - Balachandran, Kartik AD - Department of Biomedical Engineering, University of Arkansas, Fayetteville AR 72701, USA. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson AR 72079, USA. Y1 - 2016/09/14/ PY - 2016 DA - 2016 Sep 14 SP - 33330 VL - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819904076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Acetazolamide+Mitigates+Astrocyte+Cellular+Edema+Following+Mild+Traumatic+Brain+Injury.&rft.au=Sturdivant%2C+Nasya+M%3BSmith%2C+Sean+G%3BAli%2C+Syed+F%3BWolchok%2C+Jeffrey+C%3BBalachandran%2C+Kartik&rft.aulast=Sturdivant&rft.aufirst=Nasya&rft.date=2016-09-14&rft.volume=6&rft.issue=&rft.spage=33330&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep33330 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep33330 ER - TY - JOUR T1 - Krüppel-like Factor 13 Is a Major Mediator of Glucocorticoid Receptor Signaling in Cardiomyocytes and Protects These Cells from DNA Damage and Death. AN - 1818339374; 27451392 AB - Glucocorticoid receptor (GR) signaling has recently been shown to play a direct role in the regulation of cardiomyocyte function. In this study, we investigated the potential role of KLF13 as a downstream effector of GR action utilizing both in vivo and in vitro approaches. Our data show that KLF13 mRNA and protein levels are significantly diminished in the hearts of mice lacking GR in cardiomyocytes. Glucocorticoid administration up-regulated Klf13 mRNA in the mouse heart, in isolated primary cardiomyocytes, and in immortal cardiomyocyte cell lines. Glucocorticoid Klf13 gene expression was abolished by treatment with a GR antagonist (RU486) or by knockdown of GR in cardiomyocytes. Moreover, glucocorticoid induction of Klf13 mRNA was resistant to de novo protein synthesis inhibition, demonstrating that Klf13 is a direct glucocorticoid receptor gene target. A glucocorticoid responsive element (GRE) was identified in the Klf13 gene and its function was verified by chromatin immunoprecipitation in HL-1 cells and mouse hearts. Functional studies showed that GR regulation of Klf13 is critical to protect cardiomyocytes from DNA damage and cell death induced by cobalt(II) chloride hexahydrate (CoCl2·6H2O) and the antineoplastic drug doxorubicin. These results established a novel role for GR and KLF13 signaling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxicity induced heart failure. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc. JF - The Journal of biological chemistry AU - Cruz-Topete, Diana AU - He, Bo AU - Xu, Xiaojiang AU - Cidlowski, John A AD - From the Laboratory of Signal Transduction and. ; Integrative Bioinformatics, NIEHS, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709. ; From the Laboratory of Signal Transduction and cidlows1@niehs.nih.gov. Y1 - 2016/09/09/ PY - 2016 DA - 2016 Sep 09 SP - 19374 EP - 19386 VL - 291 IS - 37 KW - Index Medicus KW - Kruppel-like factor (KLF) KW - cardiomyocyte KW - gene regulation KW - hypoxia KW - glucocorticoid receptor UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1818339374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Kr%C3%BCppel-like+Factor+13+Is+a+Major+Mediator+of+Glucocorticoid+Receptor+Signaling+in+Cardiomyocytes+and+Protects+These+Cells+from+DNA+Damage+and+Death.&rft.au=Cruz-Topete%2C+Diana%3BHe%2C+Bo%3BXu%2C+Xiaojiang%3BCidlowski%2C+John+A&rft.aulast=Cruz-Topete&rft.aufirst=Diana&rft.date=2016-09-09&rft.volume=291&rft.issue=37&rft.spage=19374&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M116.725903 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1074/jbc.M116.725903 ER - TY - JOUR T1 - Physiologically Based Pharmacokinetic Prediction of Linezolid and Emtricitabine in Neonates and Infants. AN - 1859728504; 27596256 AB - Modeling and simulation approaches are increasingly being utilized in pediatric drug development. Physiologically based pharmacokinetic (PBPK) modeling offers an enhanced ability to predict age-related changes in pharmacokinetics in the pediatric population. In the current study, adult PBPK models were developed for the renally excreted drugs linezolid and emtricitabine. PBPK models were then utilized to predict pharmacokinetics in pediatric patients for various age groups from the oldest to the youngest patients in a stepwise approach. Pharmacokinetic predictions for these two drugs in the pediatric population, including infants and neonates, were within a twofold range of clinical observations. Based on this study, linezolid and emtricitabine pediatric PBPK models incorporating the ontogeny in renal maturation describe the pharmacokinetic differences between adult and pediatric populations, even though the contribution of renal clearance to the total clearance of two drugs was very different (30 % for linezolid vs. 86 % for emtricitabine). These results suggest that PBPK modeling may provide one option to help predict the pharmacokinetics of renally excreted drugs in neonates and infants. JF - Clinical pharmacokinetics AU - Duan, Peng AU - Fisher, Jeffrey W AU - Yoshida, Kenta AU - Zhang, Lei AU - Burckart, Gilbert J AU - Wang, Jian AD - Office of New Drug Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA. ; National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR, 72079, USA. ; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Building 51, Rm 2154, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA. ; Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Building 51, Rm 2154, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA. jian.wang@fda.hhs.gov. Y1 - 2016/09/06/ PY - 2016 DA - 2016 Sep 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859728504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacokinetics&rft.atitle=Physiologically+Based+Pharmacokinetic+Prediction+of+Linezolid+and+Emtricitabine+in+Neonates+and+Infants.&rft.au=Duan%2C+Peng%3BFisher%2C+Jeffrey+W%3BYoshida%2C+Kenta%3BZhang%2C+Lei%3BBurckart%2C+Gilbert+J%3BWang%2C+Jian&rft.aulast=Duan&rft.aufirst=Peng&rft.date=2016-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacokinetics&rft.issn=1179-1926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES BIODOSIMETRY AND RADIOLOGICAL/NUCLEAR MEDICAL COUNTERMEASURE PROGRAMS AN - 1855077288; PQ0003960997 AB - The United States Department of Health and Human Services (HHS) is fully committed to the development of medical countermeasures to address national security threats from chemical, biological, radiological, and nuclear agents. Through the Public Health Emergency Medical Countermeasures Enterprise, HHS has launched and managed a multi-agency, comprehensive effort to develop and operationalize medical countermeasures. Within HHS, development of medical countermeasures includes the National Institutes of Health (NIH), (led by the National Institute of Allergy and Infectious Diseases), the Office of the Assistant Secretary of Preparedness and Response/Biomedical Advanced Research and Development Authority (BARDA); with the Division of Medical Countermeasure Strategy and Requirements, the Centers for Disease Control and Prevention, and the Food and Drug Administration as primary partners in this endeavor. This paper describes various programs and coordinating efforts of BARDA and NIH for the development of medical countermeasures for radiological and nuclear threats. JF - Radiation Protection Dosimetry AU - Homer, Mary J AU - Raulli, Robert AU - Dicarlo-Cohen, Andrea L AU - Esker, John AU - Hrdina, Chad AU - Maidment, Bert W AU - Moyer, Brian AU - Rios, Carmen AU - Macchiarini, Francesca AU - Prasanna, Pataje G AU - Wathen, Lynne AD - Biomedical Advanced Research and Development Authority, Office of the Assistant Secretary for Preparedness and Response, US Department of Health and Human Services , 330 Independence Ave., SW, Room G644, Washington, DC 20201, USA, mary.homer@hhs.gov Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 85 EP - 98 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 171 IS - 1 SN - 0144-8420, 0144-8420 KW - Biotechnology and Bioengineering Abstracts; Environment Abstracts KW - Food hypersensitivity KW - Dosimetry KW - Disease control KW - Drug development KW - Allergies KW - Public health KW - Security KW - USA KW - Prevention KW - Radiation KW - Infectious diseases KW - Drugs KW - Research programs KW - W 30935:Food Biotechnology KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855077288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=UNITED+STATES+DEPARTMENT+OF+HEALTH+AND+HUMAN+SERVICES+BIODOSIMETRY+AND+RADIOLOGICAL%2FNUCLEAR+MEDICAL+COUNTERMEASURE+PROGRAMS&rft.au=Homer%2C+Mary+J%3BRaulli%2C+Robert%3BDicarlo-Cohen%2C+Andrea+L%3BEsker%2C+John%3BHrdina%2C+Chad%3BMaidment%2C+Bert+W%3BMoyer%2C+Brian%3BRios%2C+Carmen%3BMacchiarini%2C+Francesca%3BPrasanna%2C+Pataje+G%3BWathen%2C+Lynne&rft.aulast=Homer&rft.aufirst=Mary&rft.date=2016-09-01&rft.volume=171&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncw226 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Food hypersensitivity; Infectious diseases; Dosimetry; Disease control; Drug development; Public health; Security; Prevention; Radiation; Drugs; Allergies; Research programs; USA DO - http://dx.doi.org/10.1093/rpd/ncw226 ER - TY - JOUR T1 - Longitudinal diffusion tensor imaging of the rat brain after hexachlorophene exposure AN - 1837326812; PQ0003736445 AB - Longitudinal MRI employing diffusion tensor imaging and T2 mapping approaches has been applied to investigate the mechanisms of white matter damage caused by acute hexachlorophene neurotoxicity in rats in vivo. Male Sprague-Dawley rats were administered hexachlorophene orally once a day for five consecutive days at a dose of 30mg/kg and were monitored in 7T MRI scanner at days 0 (baseline), 3, 6, 13, and 20 following the first hexachlorophene dose. Quantitative T2 maps as well as a number of diffusion tensor parameters (fractional anisotropy, radial and axial diffusivity, apparent diffusion coefficient, and trace) were calculated from corresponding MR images. T2, as well as all diffusion tensor derived parameters (except fractional anisotropy) showed significant changes during the course of neurotoxicity development. These changes peaked at 6days after the first dose of hexachlorophene (one day after the last dose) and recovered to practically baseline levels at the end of observation (20days from the first dose). While such changes in diffusivity and T2 relaxation clearly demonstrate myelin perturbations consistent with edema, the lack of changes of fractional anisotropy suggests that the structure of the myelin sheath was not disrupted significantly by hexachlorophene in this study. This is also confirmed by the rapid recovery of all observed MRI parameters after cessation of hexachlorophene exposure. JF - Neurotoxicology AU - Ramu, Jaivijay AU - Konak, Tetyana AU - Paule, Merle G AU - Hanig, Joseph P AU - Liachenko, Serguei AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, United States Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 225 EP - 232 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 56 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - AD axial diffusivity KW - cc Corpus Callosum KW - Comm Commissures KW - DTI diffusion tensor imaging KW - fim Fimbria KW - HC hexachlorophene KW - IC Internal Capsule KW - FA fraction anisotropy KW - RD radial diffusivity KW - DTI KW - Axial diffusivity KW - Radial diffusivity KW - Fractional anisotropy KW - Hexachlorophene KW - Anisotropy KW - Myelin KW - Magnetic resonance imaging KW - Neurotoxicity KW - Brain KW - Substantia alba KW - Edema KW - Diffusion coefficient KW - N3 11028:Neuropharmacology & toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837326812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Longitudinal+diffusion+tensor+imaging+of+the+rat+brain+after+hexachlorophene+exposure&rft.au=Ramu%2C+Jaivijay%3BKonak%2C+Tetyana%3BPaule%2C+Merle+G%3BHanig%2C+Joseph+P%3BLiachenko%2C+Serguei&rft.aulast=Ramu&rft.aufirst=Jaivijay&rft.date=2016-09-01&rft.volume=56&rft.issue=&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2016.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Anisotropy; Myelin; Hexachlorophene; Neurotoxicity; Magnetic resonance imaging; Brain; Edema; Substantia alba; Diffusion coefficient DO - http://dx.doi.org/10.1016/j.neuro.2016.08.011 ER - TY - JOUR T1 - Single and repeated exposures to the volatile anesthetic isoflurane do not impair operant performance in aged rats AN - 1837310302; PQ0003736451 AB - Postoperative Cognitive Dysfunction (POCD) is a complication that can occur in the elderly after anesthesia and surgery and is characterized by impairments in information processing, memory, and executive function. Currently, it is unclear whether POCD is due to the effects of surgery, anesthesia, or perhaps some interaction between these or other perioperative variables. Studies in rodents suggest that the development of POCD may be related directly to anesthesia-induced neuroactivity. Volatile anesthetics have been shown to increase cellular inflammation and apoptosis within the hippocampus of aged rodents, while producing corresponding impairments in hippocampal-dependent brain functions. However, it is unclear whether volatile anesthetics can affect additional aspects of cognition that do not primarily depend upon the hippocampus. The purpose of this study was to use established operant tests to examine the effects of isoflurane on aspects of behavioral inhibition, learning, and motivation in aged rats. Twenty-one adult Sprague-Dawley rats (11 male, 10 female) were trained to perform fixed consecutive number (FCN), incremental repeated acquisition (IRA), and progressive ratio (PR) tasks for a minimum of 15 months prior to receiving anesthesia. At 23 months of age, rats were exposed to 1.3% isoflurane or medical grade air for 2h. Initial results revealed that a 2h exposure to isoflurane had no effect on IRA, FCN, or PR performance. Thus, rats received 3 additional exposures to 1.3% isoflurane or medical grade air: 2, 4 and 6h exposures with 2 weeks elapsing before exposure two, 3 weeks elapsing between exposures two and three, and 2 weeks elapsing between exposures three and four. These additional exposures had no observable effects on performance of any operant task. These results suggest that single and repeated exposures to isoflurane do not impair the performance of aged rats in tasks designed to measure behavioral inhibition, learning, and motivation. This lack of significant effect suggests that the impairments associated with isoflurane exposure may not generalize to all aspects of cognition, but may be selective to tasks that primarily measure spatial memory processes. JF - Neurotoxicology AU - Walters, Jennifer L AU - Chelonis, John J AU - Fogle, Charles M AU - Orser, Beverley A AU - Paule, Merle G AD - National Center for Toxicological Research (NCTR)/FDA, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, AR 72079, United States Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 159 EP - 169 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 56 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Anesthesia KW - Isoflurane KW - Operant behavior KW - Fixed consecutive number KW - Incremental repeated acquisition KW - Learning KW - Age KW - Apoptosis KW - Motivation KW - Operant conditioning KW - Hippocampus KW - Brain KW - Anesthetics KW - Cognition KW - Executive function KW - spatial memory KW - Memory KW - Cognitive ability KW - Volatiles KW - Surgery KW - Information processing KW - Geriatrics KW - N3 11001:Behavioral and Cognitive Neuroscience KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837310302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Single+and+repeated+exposures+to+the+volatile+anesthetic+isoflurane+do+not+impair+operant+performance+in+aged+rats&rft.au=Walters%2C+Jennifer+L%3BChelonis%2C+John+J%3BFogle%2C+Charles+M%3BOrser%2C+Beverley+A%3BPaule%2C+Merle+G&rft.aulast=Walters&rft.aufirst=Jennifer&rft.date=2016-09-01&rft.volume=56&rft.issue=&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2016.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Age; Learning; Apoptosis; Operant conditioning; Motivation; Hippocampus; Brain; Anesthetics; Cognition; Executive function; spatial memory; Memory; Anesthesia; Volatiles; Cognitive ability; Information processing; Surgery; Isoflurane; Geriatrics DO - http://dx.doi.org/10.1016/j.neuro.2016.07.012 ER - TY - JOUR T1 - INHALED AEROSOL DOSIMETRY: SOME CURRENT RESEARCH NEEDS. AN - 1835687165; 27493295 AB - After the presentation of 60 papers at the conference "Advancing Aerosol Dosimetry Research" (October 24-25, 2014 in Irvine, CA, USA), attendees submitted written descriptions of needed research. About 40 research needs were submitted. The suggestions fell into six broad categories: 1) Access to detailed anatomic data; 2) Access to subject-specific aerosol deposition datasets; 3) Improving current inhaled aerosol deposition models; 4) Some current experimental data needs and hot topics; 5) Linking exposure and deposition modeling to health endpoints; and 6) Developing guidelines for appropriate validation of dosimetry and risk assessment models. Summaries of suggestions are provided here as an update on research needs related to inhaled aerosol dosimetry modeling. Taken together, the recommendations support the overarching need for increased collaborations between dose modelers and those that use the models for risk assessments, aerosol medicine applications, design of toxicology experiments, and extrapolation across species. This paper is only a snapshot in time of perceived research needs from the conference attendees; it does not carry the approval of any agency or other group that plans research priorities or that funds research. JF - Journal of aerosol science AU - Darquenne, Chantal AU - Hoover, Mark D AU - Phalen, Robert F AD - Department of Medicine, University of California, San Diego, CA 92093-0623, USA. ; Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, VA 26505-2888, USA. ; Department of Medicine, Center for Occupational and Environmental Health, University of California, Irvine, CA 92617-1830, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1 EP - 5 VL - 99 SN - 0021-8502, 0021-8502 KW - particle deposition KW - risk assessment KW - lung models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835687165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+aerosol+science&rft.atitle=INHALED+AEROSOL+DOSIMETRY%3A+SOME+CURRENT+RESEARCH+NEEDS.&rft.au=Darquenne%2C+Chantal%3BHoover%2C+Mark+D%3BPhalen%2C+Robert+F&rft.aulast=Darquenne&rft.aufirst=Chantal&rft.date=2016-09-01&rft.volume=99&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+aerosol+science&rft.issn=00218502&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Bridging the gap between exposure assessment and inhalation toxicology: Some insights from the carbon nanotube experience. AN - 1835665541; 27546900 AB - The early incorporation of exposure assessment can be invaluable to help design, prioritize, and interpret toxicological studies or outcomes. The sum total of the exposure assessment findings combined with preliminary toxicology results allows for exposure-informed toxicological study design and the findings can then be integrated, together with available epidemiologic data, to provide health effect relevance. With regard to engineered nanomaterial inhalation toxicology in particular, a single type of material (e.g. carbon nanotube, graphene) can have a vast array of physicochemical characteristics resulting in the potential for varying toxicities. To compound the matter, the methodologies necessary to establish a material adequate for in vivo exposure testing raises questions on the applicability of the outcomes. From insights gained from evaluating carbon nanotubes, we recommend the following integrated approach involving exposure-informed hazard assessment and hazard-informed exposure assessment especially for materials as diverse as engineered nanomaterials: 1) market-informed identification of potential hazards and potentially exposed populations, 2) initial toxicity screening to drive prioritized assessments of exposure, 3) development of exposure assessment-informed chronic and sub-chronic in vivo studies, and 4) conduct of exposure- and hazard-informed epidemiological studies. JF - Journal of aerosol science AU - Erdely, Aaron AU - Dahm, Matthew M AU - Schubauer-Berigan, Mary K AU - Chen, Bean T AU - Antonini, James M AU - Hoover, Mark D AD - Health Effects Laboratory Division, NIOSH/HELD/PPRB, 1095 Willowdale Rd, MS-2015, Morgantown, WV 26505, USA. ; Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH 45226, USA. ; Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 157 EP - 162 VL - 99 SN - 0021-8502, 0021-8502 KW - Inhalation KW - Epidemiology KW - Carbon nanotube KW - Exposure assessment KW - Toxicology KW - Nanomaterial UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835665541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+aerosol+science&rft.atitle=Bridging+the+gap+between+exposure+assessment+and+inhalation+toxicology%3A+Some+insights+from+the+carbon+nanotube+experience.&rft.au=Erdely%2C+Aaron%3BDahm%2C+Matthew+M%3BSchubauer-Berigan%2C+Mary+K%3BChen%2C+Bean+T%3BAntonini%2C+James+M%3BHoover%2C+Mark+D&rft.aulast=Erdely&rft.aufirst=Aaron&rft.date=2016-09-01&rft.volume=99&rft.issue=&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Journal+of+aerosol+science&rft.issn=00218502&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S . mansoni Infections: A Randomized, Exploratory Phase 2 Trial AN - 1829442736 AB - Background Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or clinical studies. Methodology We conducted two single-blind, randomized exploratory Phase 2 trials in Schistosoma mansoni and S. haematobium-infected adolescents in northern and central Côte d'Ivoire. Our primary endpoints were cure rates (CRs) and egg reduction rates (ERRs) based on geometric mean and safety. Each subject was asked to provide two stool samples (S. mansoni trial) for Kato-Katz analysis or three urine samples (S. haematobium trial) for urine filtration and one finger prick for malaria screening at baseline and follow-up. Participants were randomly assigned to either moxidectin, Synriam, Synriam plus praziquantel or praziquantel. Principal Findings 128 adolescents (age: 12-17 years) were included in each study. Against S. haematobium moxidectin and Synriam revealed low efficacy. On the other hand, Synriam plus praziquantel and praziquantel yielded CRs of 60.0% and 38.5% and ERRs of 96.0% and 93.5%, respectively. CRs observed in the treatment of S. mansoni were 13.0%, 6.7%, 27.0%, and 27.6% for moxidectin, Synriam, Synriam plus praziquantel and praziquantel, respectively. ERRs ranged from 64.9% (Synriam) to 87.5% (praziquantel). Conclusion/Significance Synriam and moxidectin show low efficacy against S. haematobium, hence an ancillary benefit is not expected when these drugs are used for treating onchocerciasis and malaria in co-endemic settings. Further studies are needed to corroborate our findings that moxidectin and Synriam show moderate ERRs against S. mansoni. JF - PLoS Neglected Tropical Diseases AU - Barda, Beatrice AU - Coulibaly, Jean T AU - Puchkov, Maxim AU - Huwyler, Jörg AU - Hattendorf, Jan AU - Keiser, Jennifer Y1 - 2016/09// PY - 2016 DA - Sep 2016 CY - San Francisco PB - Public Library of Science VL - 10 IS - 9 KW - Medical Sciences--Communicable Diseases KW - Biology KW - Pharmaceuticals KW - Drugs KW - Public health KW - Teenagers KW - Studies KW - Infections KW - Urine KW - Tropical diseases KW - Funding KW - Malaria KW - Pharmaceutical sciences KW - Parasitology KW - Switzerland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1829442736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Efficacy+and+Safety+of+Moxidectin%2C+Synriam%2C+Synriam-Praziquantel+versus+Praziquantel+against+Schistosoma+haematobium+and+S+.+mansoni+Infections%3A+A+Randomized%2C+Exploratory+Phase+2+Trial&rft.au=Barda%2C+Beatrice%3BCoulibaly%2C+Jean+T%3BPuchkov%2C+Maxim%3BHuwyler%2C+J%C3%B6rg%3BHattendorf%2C+Jan%3BKeiser%2C+Jennifer&rft.aulast=Barda&rft.aufirst=Beatrice&rft.date=2016-09-01&rft.volume=10&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pntd.0005008 LA - English DB - ProQuest Central N1 - Name - University of Basel N1 - Copyright - © 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Infections: A Randomized, Exploratory Phase 2 Trial. PLoS Negl Trop Dis 10(9): e0005008. doi:10.1371/journal.pntd.0005008 N1 - Last updated - 2016-10-17 N1 - SubjectsTermNotLitGenreText - Switzerland DO - http://dx.doi.org/10.1371/journal.pntd.0005008 ER - TY - JOUR T1 - StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control AN - 1829442219 AB - Marco Albonico, Sören L. Becker, Peter Odermatt Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland Andrea Angheben Affiliation: Centre for Tropical Diseases, Sacro Cuore Hospital, Negrar, Verona, Italy Mariella Anselmi Affiliation: Centro de Epidemiología Comunitaria y Medicina Tropical, Esmeraldas, Ecuador Arancha Amor Affiliation: Mundo Sano Foundation, Buenos Aires, Argentina Beatrice Barda Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland Dora Buonfrate Affiliation: Centre for Tropical Diseases, Sacro Cuore Hospital, Negrar, Verona, Italy Philip Cooper Affiliation: Facultad de Ciencias Medicas, de la Salud y la Vida, Universidad Internacional del Ecuador, Quito, Ecuador Laurent Gétaz Affiliation: University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland Jennifer Keiser Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland Virak Khieu Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland, National Center for Parasitology, Entomology and Malaria Control, Ministry of Health, Phnom Penh, Cambodia Antonio Montresor Affiliation: Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland José Muñoz Affiliation: ISGlobal, Barcelona Centre for International Health Research, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain Ana Requena-Méndez Affiliation: ISGlobal, Barcelona Centre for International Health Research, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain Lorenzo Savioli Affiliation: Global Schistosomiasis Alliance, Chavannes de Bogis, Switzerland Richard Speare [dagger] Deceased. [...]clinical, diagnostic, epidemiologic, treatment, and control aspects are not adequately addressed to allow for an effective management of the disease, both in clinical medicine and in public health programs [4]. JF - PLoS Neglected Tropical Diseases AU - Albonico, Marco AU - Becker, Sören L AU - Odermatt, Peter AU - Angheben, Andrea AU - Anselmi, Mariella AU - Amor, Arancha AU - Barda, Beatrice AU - Buonfrate, Dora AU - Cooper, Philip AU - Gétaz, Laurent AU - Keiser, Jennifer AU - Khieu, Virak AU - Montresor, Antonio AU - Muñoz, José AU - Requena-Méndez, Ana AU - Savioli, Lorenzo AU - Speare, Richard AU - Steinmann, Peter AU - Lieshout, Lisette van AU - Utzinger, Jürg AU - Bisoffi, Zeno AU - Group, StrongNet Working Y1 - 2016/09// PY - 2016 DA - Sep 2016 CY - San Francisco PB - Public Library of Science VL - 10 IS - 9 KW - Medical Sciences--Communicable Diseases KW - Tropical diseases KW - Colleges & universities KW - Abdomen KW - Hospitals KW - Disease KW - Public health KW - Infections KW - Medical research KW - Drug dosages KW - Funding KW - Malaria KW - Parasitology KW - Working groups KW - Switzerland UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1829442219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=StrongNet%3A+An+International+Network+to+Improve+Diagnostics+and+Access+to+Treatment+for+Strongyloidiasis+Control&rft.au=Albonico%2C+Marco%3BBecker%2C+S%C3%B6ren+L%3BOdermatt%2C+Peter%3BAngheben%2C+Andrea%3BAnselmi%2C+Mariella%3BAmor%2C+Arancha%3BBarda%2C+Beatrice%3BBuonfrate%2C+Dora%3BCooper%2C+Philip%3BG%C3%A9taz%2C+Laurent%3BKeiser%2C+Jennifer%3BKhieu%2C+Virak%3BMontresor%2C+Antonio%3BMu%C3%B1oz%2C+Jos%C3%A9%3BRequena-M%C3%A9ndez%2C+Ana%3BSavioli%2C+Lorenzo%3BSpeare%2C+Richard%3BSteinmann%2C+Peter%3BLieshout%2C+Lisette+van%3BUtzinger%2C+J%C3%BCrg%3BBisoffi%2C+Zeno%3BGroup%2C+StrongNet+Working&rft.aulast=Albonico&rft.aufirst=Marco&rft.date=2016-09-01&rft.volume=10&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pntd.0004898 LA - English DB - ProQuest Central N1 - Name - University of Basel N1 - Copyright - © 2016 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Albonico M, Becker SL, Odermatt P, Angheben A, Anselmi M, Amor A, et al. (2016) StrongNet: An International Network to Improve Diagnostics and Access to Treatment for Strongyloidiasis Control. PLoS Negl Trop Dis 10(9): e0004898. doi:10.1371/journal.pntd.0004898 N1 - Last updated - 2016-10-17 N1 - SubjectsTermNotLitGenreText - Switzerland DO - http://dx.doi.org/10.1371/journal.pntd.0004898 ER - TY - JOUR T1 - Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus AN - 1827931751; PQ0003606407 AB - Cells use the post-translational modification ADP-ribosylation to control a host of biological activities. In some pathogenic bacteria, an operon-encoded mono-ADP-ribosylation cycle mediates response to host-induced oxidative stress. In this system, reversible mono ADP-ribosylation of a lipoylated target protein represses oxidative stress response. An NAD super(+)-dependent sirtuin catalyzes the single ADP-ribose (ADPr) addition, while a linked macrodomain-containing protein removes the ADPr. Here we report the crystal structure of the sitruin-linked macrodomain protein from Staphylococcus aureus, SauMacro (also known as SAV0325) to 1.75-Aa resolution. The monomeric SauMacro bears a previously unidentified Zn super(2+)-binding site that putatively aids in substrate recognition and catalysis. An amino-terminal three-helix bundle motif unique to this class of macrodomain proteins provides a structural scaffold for the Zn super(2+) site. Structural features of the enzyme further indicate a cleft proximal to the Zn super(2+) binding site appears well suited for ADPr binding, while a deep hydrophobic channel in the protein core is suitable for binding the lipoate of the lipoylated protein target. JF - Protein Science AU - Appel, CDenise AU - Feld, Geoffrey K AU - Wallace, Bret D AU - Williams, RScott AD - Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, US National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, 27709. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1682 EP - 1691 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 9 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - Post-translation KW - Oxidative stress KW - Zinc KW - Sirtuins KW - Crystal structure KW - Enzymes KW - Hydrophobicity KW - Staphylococcus aureus KW - ADP-ribosylation KW - scaffolds KW - Catalysis KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827931751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Structure+of+the+sirtuin-linked+macrodomain+SAV0325+from+Staphylococcus+aureus&rft.au=Appel%2C+CDenise%3BFeld%2C+Geoffrey+K%3BWallace%2C+Bret+D%3BWilliams%2C+RScott&rft.aulast=Appel&rft.aufirst=CDenise&rft.date=2016-09-01&rft.volume=25&rft.issue=9&rft.spage=1682&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/10.1002%2Fpro.2974 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Post-translation; Oxidative stress; Zinc; Crystal structure; Sirtuins; Enzymes; Hydrophobicity; ADP-ribosylation; scaffolds; Catalysis; Staphylococcus aureus DO - http://dx.doi.org/10.1002/pro.2974 ER - TY - JOUR T1 - TECHNICAL RECOMMENDATIONS FOR MONITORING INDIVIDUALS FOR OCCUPATIONAL INTAKES OF RADIONUCLIDES AN - 1827929403; PQ0003673710 AB - The TECHREC project, funded by the European Commission, will provide Technical Recommendations for Monitoring Individuals for Occupational Intakes of Radionuclides. It is expected that the document will be published by the European Commission as a report in its Radiation Protection Series during 2016. The project is coordinated by the European Radiation Dosimetry Group (EURADOS) and is being carried out by members of EURADOS Working Group 7 (Internal Dosimetry). This paper describes the aims and purpose of the Technical Recommendations, and explains how the project is organised. JF - Radiation Protection Dosimetry AU - Etherington, G AU - Berard, P AU - Blanchardon, E AU - Breustedt, B AU - Castellani, C M AU - Vathaire, C Challeton-de AU - Giussani, A AU - Franck, D AU - Lopez, M A AU - Marsh, J W AU - Nosske, D AD - Public Health England (PHE), Centre for Radiation Chemical and Environmental Hazards, Didcot, UK, george.etherington@phe.gov.uk Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 8 EP - 12 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 170 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Toxicology Abstracts; Environment Abstracts KW - Radiation KW - Dosimetry KW - Radioisotopes KW - Radiation dosimetry KW - X 24390:Radioactive Materials KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827929403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=TECHNICAL+RECOMMENDATIONS+FOR+MONITORING+INDIVIDUALS+FOR+OCCUPATIONAL+INTAKES+OF+RADIONUCLIDES&rft.au=Etherington%2C+G%3BBerard%2C+P%3BBlanchardon%2C+E%3BBreustedt%2C+B%3BCastellani%2C+C+M%3BVathaire%2C+C+Challeton-de%3BGiussani%2C+A%3BFranck%2C+D%3BLopez%2C+M+A%3BMarsh%2C+J+W%3BNosske%2C+D&rft.aulast=Etherington&rft.aufirst=G&rft.date=2016-09-01&rft.volume=170&rft.issue=1-4&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncv395 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Radiation; Dosimetry; Radioisotopes; Radiation dosimetry DO - http://dx.doi.org/10.1093/rpd/ncv395 ER - TY - JOUR T1 - CALIBRATION OF THERMOLUMINESCENCE AND FILM DOSEMETERS FOR SKIN DOSES FROM HIGH-ACTIVITY MICROPARTICLES AN - 1827927779; PQ0003673747 AB - The use of EXT-RAD(TM) extremity TLDs and radiochromic film to measure doses from primarily beta-emitting microparticles is discussed. Specific calibration techniques have been developed, using both Monte Carlo modelling and experiments. Results for a super(90) Sr/ super(90) Y microparticle are presented to illustrate the general techniques and to demonstrate reasonable agreement between the dosimetry methods. JF - Radiation Protection Dosimetry AU - Eakins, J S AU - Hager, L G AU - Tanner, R J AD - Public Health England, CRCE, Chilton, Didcot, Oxon OX11 0RQ, UK, jonathan.eakins@phe.gov.uk Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 173 EP - 176 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 170 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Monte Carlo simulation KW - Extremities KW - Skin KW - Radiation KW - Dosimetry KW - Thermoluminescence KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827927779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=CALIBRATION+OF+THERMOLUMINESCENCE+AND+FILM+DOSEMETERS+FOR+SKIN+DOSES+FROM+HIGH-ACTIVITY+MICROPARTICLES&rft.au=Eakins%2C+J+S%3BHager%2C+L+G%3BTanner%2C+R+J&rft.aulast=Eakins&rft.aufirst=J&rft.date=2016-09-01&rft.volume=170&rft.issue=1-4&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncv437 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Extremities; Monte Carlo simulation; Skin; Radiation; Dosimetry; Thermoluminescence DO - http://dx.doi.org/10.1093/rpd/ncv437 ER - TY - JOUR T1 - Deactivation of the left dorsolateral prefrontal cortex in Prader-Willi syndrome after meal consumption AN - 1827927237; PQ0003681734 AB - Background/ Objectives: Prader-Willi syndrome (PWS) is a type of human genetic obesity that may give us information regarding the physiology of non-syndromic obesity. The objective of this study was to investigate the functional correlates of hunger and satiety in individuals with PWS in comparison with healthy controls with obesity, hypothesizing that we would see significant differences in activation in the left dorsolateral prefrontal cortex (DLPFC) based on prior findings.Subjects/ Methods: This study compared the central effects of food consumption in nine individuals with PWS (7 men, 2 women; body fat 35.3 plus or minus 10.0%) and seven controls (7 men; body fat 28.8 plus or minus 7.6%), matched for percentage body fat. H sub(2) super(15)O-PET (positron emission tomography) scans were performed before and after consumption of a standardized liquid meal to obtain quantitative measures of regional cerebral blood flow (rCBF), a marker of neuronal activity. Results: Compared with obese controls, PWS showed altered (P<0.05 family-wise error cluster-level corrected; voxelwise P<0.001) rCBF before and after meal consumption in multiple brain regions. There was a significant differential rCBF response within the left DLPFC after meal ingestion with decreases in DLPFC rCBF in PWS; in controls, DLPFC rCBF tended to remain unchanged. In more liberal analyses (P<0.05 family-wise error cluster-level corrected; voxelwise P<0.005), rCBF of the right orbitofrontal cortex (OFC) increased in PWS and decreased in controls. In PWS, Delta rCBF of the right OFC was associated with changes in appetite ratings. Conclusions: The pathophysiology of eating behavior in PWS is characterized by a paradoxical meal-induced deactivation of the left DLPFC and activation in the right OFC, brain regions implicated in the central regulation of eating behavior. JF - International Journal of Obesity AU - Reinhardt, M AU - Parigi, A D AU - Chen, K AU - Reiman, E M AU - Thiyyagura, P AU - Krakoff, J AU - Hohenadel, M G AU - Le, D S N T AU - Weise, C M AD - Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ, USA; Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1360 EP - 1368 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 40 IS - 9 SN - 0307-0565, 0307-0565 KW - CSA Neurosciences Abstracts; Health & Safety Science Abstracts KW - Hunger KW - Obesity KW - Satiety KW - Physiology KW - Brain KW - Prader-Willi syndrome KW - Ingestion KW - Appetite KW - Blood KW - Food consumption KW - Emissions KW - Positron emission tomography KW - Body fat KW - Standards KW - Deactivation KW - Cortex (prefrontal) KW - Cerebral blood flow KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - N3 11023:Neurogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827927237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Deactivation+of+the+left+dorsolateral+prefrontal+cortex+in+Prader-Willi+syndrome+after+meal+consumption&rft.au=Reinhardt%2C+M%3BParigi%2C+A+D%3BChen%2C+K%3BReiman%2C+E+M%3BThiyyagura%2C+P%3BKrakoff%2C+J%3BHohenadel%2C+M+G%3BLe%2C+D+S+N+T%3BWeise%2C+C+M&rft.aulast=Reinhardt&rft.aufirst=M&rft.date=2016-09-01&rft.volume=40&rft.issue=9&rft.spage=1360&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fijo.2016.75 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Hunger; Food consumption; Obesity; Satiety; Positron emission tomography; Brain; Prader-Willi syndrome; Body fat; Deactivation; Appetite; Cerebral blood flow; Cortex (prefrontal); Blood; Physiology; Emissions; Standards; Ingestion DO - http://dx.doi.org/10.1038/ijo.2016.75 ER - TY - JOUR T1 - Regulation of New Drug Approval in Taiwan AN - 1827925056; PQ0003637382 AB - Taiwan Food and Drug Administration (TFDA) was established in 2010 as the nation's principal consumer product protection agency of food, drugs, medical devices, and cosmetics. By integrating 4 agencies (the Bureau of Food Safety, Bureau of Pharmaceutical Affairs, Bureau of Food and Drug Analysis, and Bureau of Controlled Drugs), TFDA holds the mission of protecting and promoting the public health through regulation modernization to enhance the availability of safe medical products and foods. To address the unmet medical needs and public health, TFDA has utilized regulatory science to evaluate review principles and risk management to properly oversee the overall life cycle of medicinal products. A lot of measures have been accomplished to build an efficient, transparent, and internationally harmonized regulatory system. With the first-in-the-world new drug afatinib approved in Taiwan, TFDA has successfully built up capacity and capability in the review and approval of new drugs. This article summarizes the efforts TFDA has been making in the domain of medicinal product management, highlighting policies and strategies for the future. JF - Therapeutic Innovation & Regulatory Science AU - Yang, Ya-Ting AU - Huang, Hsiau-Wen AU - Chen, Ya-Ting AU - Chiang, Yu-Mei AU - Tzou, Meir-Chyun AD - 1 .Taiwan Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan, pamctzou@fda.gov.tw Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 602 EP - 608 PB - Sage Publications, Inc. VL - 50 IS - 5 SN - 2168-4790, 2168-4790 KW - Biotechnology and Bioengineering Abstracts KW - Taiwan Food and Drug Administration (TFDA) KW - new drug approval KW - good review practice (GRevP) KW - multiple review tracks KW - multiregional clinical trial (MRCT) KW - ICH guidelines KW - Medical equipment KW - Reviews KW - Life cycle KW - Pharmaceuticals KW - Cosmetics KW - Consumers KW - Public health KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827925056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Therapeutic+Innovation+%26+Regulatory+Science&rft.atitle=Regulation+of+New+Drug+Approval+in+Taiwan&rft.au=Yang%2C+Ya-Ting%3BHuang%2C+Hsiau-Wen%3BChen%2C+Ya-Ting%3BChiang%2C+Yu-Mei%3BTzou%2C+Meir-Chyun&rft.aulast=Yang&rft.aufirst=Ya-Ting&rft.date=2016-09-01&rft.volume=50&rft.issue=5&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Therapeutic+Innovation+%26+Regulatory+Science&rft.issn=21684790&rft_id=info:doi/10.1177%2F2168479016640317 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 16 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Medical equipment; Reviews; Pharmaceuticals; Life cycle; Consumers; Cosmetics; Public health DO - http://dx.doi.org/10.1177/2168479016640317 ER - TY - JOUR T1 - Whole-Genome Sequencing for Detecting Antimicrobial Resistance in Nontyphoidal Salmonella AN - 1827904757; PQ0003647309 AB - Laboratory-based in vitro antimicrobial susceptibility testing is the foundation for guiding anti-infective therapy and monitoring antimicrobial resistance trends. We used whole-genome sequencing (WGS) technology to identify known antimicrobial resistance determinants among strains of nontyphoidal Salmonella and correlated these with susceptibility phenotypes to evaluate the utility of WGS for antimicrobial resistance surveillance. Six hundred forty Salmonella of 43 different serotypes were selected from among retail meat and human clinical isolates that were tested for susceptibility to 14 antimicrobials using broth microdilution. The MIC for each drug was used to categorize isolates as susceptible or resistant based on Clinical and Laboratory Standards Institute clinical breakpoints or National Antimicrobial Resistance Monitoring System (NARMS) consensus interpretive criteria. Each isolate was subjected to whole-genome shotgun sequencing, and resistance genes were identified from assembled sequences. A total of 65 unique resistance genes, plus mutations in two structural resistance loci, were identified. There were more unique resistance genes (n = 59) in the 104 human isolates than in the 536 retail meat isolates (n = 36). Overall, resistance genotypes and phenotypes correlated in 99.0% of cases. Correlations approached 100% for most classes of antibiotics but were lower for aminoglycosides and beta-lactams. We report the first finding of extended-spectrum beta -lactamases (ESBLs) (blaCTX-M1 and blaSHV2a) in retail meat isolates of Salmonella in the United States. Whole-genome sequencing is an effective tool for predicting antibiotic resistance in nontyphoidal Salmonella, although the use of more appropriate surveillance breakpoints and increased knowledge of new resistance alleles will further improve correlations. JF - Antimicrobial Agents & Chemotherapy AU - McDermott, Patrick F AU - Tyson, Gregory H AU - Kabera, Claudine AU - Chen, Yuansha AU - Li, Cong AU - Folster, Jason P AU - Ayers, Sherry L AU - Lam, Claudia AU - Tate, Heather P AU - Zhao, Shaohua AD - << + $0, Patrick.McDermott@fda.hhs.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 5515 EP - 5520 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 60 IS - 9 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - beta -Lactamase KW - Serotypes KW - Drug resistance KW - Antibiotics KW - Genotypes KW - Minimum inhibitory concentration KW - Aminoglycoside antibiotics KW - Antimicrobial agents KW - Meat KW - Breakpoints KW - Salmonella KW - Mutation KW - Antibiotic resistance KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827904757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Whole-Genome+Sequencing+for+Detecting+Antimicrobial+Resistance+in+Nontyphoidal+Salmonella&rft.au=McDermott%2C+Patrick+F%3BTyson%2C+Gregory+H%3BKabera%2C+Claudine%3BChen%2C+Yuansha%3BLi%2C+Cong%3BFolster%2C+Jason+P%3BAyers%2C+Sherry+L%3BLam%2C+Claudia%3BTate%2C+Heather+P%3BZhao%2C+Shaohua&rft.aulast=McDermott&rft.aufirst=Patrick&rft.date=2016-09-01&rft.volume=60&rft.issue=9&rft.spage=5515&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.01030-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 34 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Serotypes; beta -Lactamase; Drug resistance; Antibiotics; Genotypes; Minimum inhibitory concentration; Aminoglycoside antibiotics; Antimicrobial agents; Meat; Breakpoints; Mutation; Antibiotic resistance; Salmonella DO - http://dx.doi.org/10.1128/AAC.01030-16 ER - TY - JOUR T1 - Pharmacovigilance activities in ASEAN countries AN - 1827904063; PQ0003649857 AB - Purpose This study aimed to explore the current landscape and identify challenges of pharmacovigilance (PV) among Association of Southeast Asian Nations (ASEAN) countries. Methods This cross-sectional survey collected data from May 2014 to December 2015. Questionnaires seeking to collect information on resources, processes, roles and responsibility, and functions of PV systems were sent to relevant persons in the ASEAN countries. Functions of PV centers were measured using the minimum World Health Organization requirements for a functional national PV system. Performances of PV centers were measured by the following: (1) the indicators related to the average number of individual case safety reports (ICSR); (2) presence of signal detection activities and subsequent action; and (3) contribution to the global vigilance database. Results Cambodia, Indonesia, Laos, Malaysia, the Philippines, Singapore, Thailand, and Vietnam completed the survey. PV systems in four surveyed countries (Indonesia, Malaysia, Singapore, and Thailand) achieved all aspects of the World Health Organization minimum requirement for a functional national PV system; the remaining countries were deemed to have unclear communication strategies and/or no official advisory committee. Average numbers of recent ICSR national returns ranged from 7 to 3817 reports/year/million population; three countries (Malaysia, Singapore, and Thailand) demonstrated good performance in reporting system and reported signal detection activities and subsequent actions. All participating countries had submitted ICSRs to the Uppsala Monitoring Center during the survey period (2013-2015). Conclusions Four participating countries had functional PV systems. PV capacity, functionality, and legislative framework varied depending on local healthcare ecosystem networks. Implementing effective communication strategies and/or technical assistance from the advisory committee are needed to strengthen PV in ASEAN. JF - Pharmacoepidemiology and Drug Safety AU - Suwankesawong, Wimon AU - Dhippayom, Teerapon AU - Tan-Koi, Wei-Chuen AU - Kongkaew, Chuenjid AD - Health Product Vigilance Center, Thai Food and Drug Administration, Nonthaburi, Thailand. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1061 EP - 1069 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 9 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts KW - Inventories KW - Databases KW - Data processing KW - Information processing KW - Landscape KW - Communication KW - Vigilance KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827904063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Pharmacovigilance+activities+in+ASEAN+countries&rft.au=Suwankesawong%2C+Wimon%3BDhippayom%2C+Teerapon%3BTan-Koi%2C+Wei-Chuen%3BKongkaew%2C+Chuenjid&rft.aulast=Suwankesawong&rft.aufirst=Wimon&rft.date=2016-09-01&rft.volume=25&rft.issue=9&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Databases; Inventories; Data processing; Information processing; Landscape; Communication; Vigilance DO - http://dx.doi.org/10.1002/pds.4023 ER - TY - JOUR T1 - The ChrSA and HrrSA Two-Component Systems Are Required for Transcriptional Regulation of the hemA Promoter in Corynebacterium diphtheriae AN - 1827901203; PQ0003647445 AB - Corynebacterium diphtheriae utilizes heme and hemoglobin (Hb) as iron sources for growth in low-iron environments. In C. diphtheriae, the two-component signal transduction systems (TCSs) ChrSA and HrrSA are responsive to Hb levels and regulate the transcription of promoters for hmuO, hrtAB, and hemA. ChrSA and HrrSA activate transcription at the hmuO promoter and repress transcription at hemA in an Hb-dependent manner. In this study, we show that HrrSA is the predominant repressor at hemA and that its activity results in transcriptional repression in the presence and absence of Hb, whereas repression of hemA by ChrSA is primarily responsive to Hb. DNA binding studies showed that both ChrA and HrrA bind to the hemA promoter region at virtually identical sequences. ChrA binding was enhanced by phosphorylation, while binding to DNA by HrrA was independent of its phosphorylation state. ChrA and HrrA are phosphorylated in vitro by the sensor kinase ChrS, whereas no kinase activity was observed with HrrS in vitro. Phosphorylated ChrA was not observed in vivo, even in the presence of Hb, which is likely due to the instability of the phosphate moiety on ChrA. However, phosphorylation of HrrA was observed in vivo regardless of the presence of the Hb inducer, and genetic analysis indicates that ChrS is responsible for most of the phosphorylation of HrrA in vivo. Phosphorylation studies strongly suggest that HrrS functions primarily as a phosphatase and has only minimal kinase activity. These findings collectively show a complex mechanism of regulation at the hemA promoter, where both two-component systems act in concert to optimize expression of heme biosynthetic enzymes. IMPORTANCE Understanding the mechanism by which two-component signal transduction systems function to respond to environmental stimuli is critical to the study of bacterial pathogenesis. The current study expands on the previous analyses of the ChrSA and HrrSA TCSs in the human pathogen C. diphtheriae. The findings here underscore the complex interactions between the ChrSA and HrrSA systems in the regulation of the hemA promoter and demonstrate how the two systems complement one another to refine and control transcription in the presence and absence of Hb. JF - Journal of Bacteriology AU - Burgos, Jonathan M AU - Schmitt, Michael P Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 2419 EP - 2430 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 198 IS - 18 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Heme KW - Nucleotide sequence KW - Genetic analysis KW - Transcription KW - Enzymes KW - Corynebacterium diphtheriae KW - Pathogens KW - Hemoglobin KW - Promoters KW - Phosphorylation KW - Phosphate KW - Gene regulation KW - DNA KW - Environmental effects KW - Repressors KW - Iron KW - Gene silencing KW - Signal transduction KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827901203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=The+ChrSA+and+HrrSA+Two-Component+Systems+Are+Required+for+Transcriptional+Regulation+of+the+hemA+Promoter+in+Corynebacterium+diphtheriae&rft.au=Burgos%2C+Jonathan+M%3BSchmitt%2C+Michael+P&rft.aulast=Burgos&rft.aufirst=Jonathan&rft.date=2016-09-01&rft.volume=198&rft.issue=18&rft.spage=2419&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00339-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 49 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Heme; Nucleotide sequence; Genetic analysis; Enzymes; Transcription; Pathogens; Hemoglobin; Promoters; Phosphate; Phosphorylation; Gene regulation; Environmental effects; DNA; Iron; Repressors; Signal transduction; Gene silencing; Corynebacterium diphtheriae DO - http://dx.doi.org/10.1128/JB.00339-16 ER - TY - JOUR T1 - Design and analysis choices for safety surveillance evaluations need to be tuned to the specifics of the hypothesized drug-outcome association AN - 1827900683; PQ0003649862 AB - Background We reviewed the results of the Observational Medical Outcomes Research Partnership (OMOP) 2010 Experiment in hopes of finding examples where apparently well-designed drug studies repeatedly produce anomalous findings. OMOP had applied thousands of designs and design parameters to 53 drug-outcome pairs across 10 electronic data resources. Our intent was to use this repository to elucidate some sources of error in observational studies. Method From the 2010 OMOP Experiment, we sought drug-outcome-method combinations (DOMCs) that met consensus design criteria, yet repeatedly produced results contrary to expectation. We set aside DOMCs for which we could not agree on the suitability of the designs, then selected for an in-depth scrutiny one drug-outcome pair analyzed by a seemingly plausible methodological approach, whose results consistently disagreed with the a priori expectation. Results The OMOP "all-by-all" assessment of possible DOMCs yielded many combinations that would not be chosen by researchers as actual study options. Among those that passed a first level of scrutiny, two of seven drug-outcome pairs for which there were plausible research designs had anomalous results. The use of benzodiazepines was unexpectedly associated with acute renal failure and upper gastrointestinal bleeding. We chose the latter as an example for in-depth study. The factitious appearance of a bleeding risk may have been partly driven by an excess of procedures on the first day of treatment. A risk window definition that excluded the first day largely removed the spurious association. Conclusion One cause of reproducible "error" may be repeated failure to tie design choices closely enough to the research question at hand. JF - Pharmacoepidemiology and Drug Safety AU - Gruber, Susan AU - Chakravarty, Aloka AU - Heckbert, Susan R AU - Levenson, Mark AU - Martin, David AU - Nelson, Jennifer C AU - Psaty, Bruce M AU - Pinheiro, Simone AU - Reich, Christian G AU - Toh, Sengwee AU - Walker, Alexander M AD - Reagan-Udall Foundation for the FDA, Innovation in Medical Evidence Development and Surveillance, Washington, DC, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 973 EP - 981 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 9 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts KW - Data processing KW - Reviews KW - Benzodiazepine KW - Bleeding KW - Renal failure KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827900683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Design+and+analysis+choices+for+safety+surveillance+evaluations+need+to+be+tuned+to+the+specifics+of+the+hypothesized+drug-outcome+association&rft.au=Gruber%2C+Susan%3BChakravarty%2C+Aloka%3BHeckbert%2C+Susan+R%3BLevenson%2C+Mark%3BMartin%2C+David%3BNelson%2C+Jennifer+C%3BPsaty%2C+Bruce+M%3BPinheiro%2C+Simone%3BReich%2C+Christian+G%3BToh%2C+Sengwee%3BWalker%2C+Alexander+M&rft.aulast=Gruber&rft.aufirst=Susan&rft.date=2016-09-01&rft.volume=25&rft.issue=9&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Data processing; Reviews; Benzodiazepine; Bleeding; Renal failure; Drugs DO - http://dx.doi.org/10.1002/pds.4065 ER - TY - JOUR T1 - Uptake of new drugs in the early post-approval period in the Mini-Sentinel distributed database AN - 1827899616; PQ0003649864 AB - Purpose Several factors limit the statistical power of drug safety surveillance during the early post-approval period, including uptake of the drug and lag in data availability. This study characterized new drug uptake in the Mini-Sentinel Distributed Database and determined statistical power to detect levels of risk in post-launch safety assessments. Methods The cumulative exposure among initiators of 46 new molecular entities approved from 2008 to 2011 was assessed. Using a Poisson estimation method, minimum incidence rate ratios (IRRs) detectable, with 80% power, were calculated under varying background incidence rates. Results Twelve products (26.1%) had more than 15000 new users after 2years. With comparator group incidence rate of 1/1000 person-years, 16 (33.3%) products had enough exposure to detect an IRR of 5 with 24months of data collected that would be available for assessment at 33months post-launch. With an incidence rate of 5/1000 person-years, 23 (50%) products had enough exposure to detect an IRR of greater than or equal to 3 with 2years of data collected. At 33months post-launch, only two (4.3%) of the drugs examined had enough data availability to detect IRR of <2, and eight (17.4%) of <3, with a background rate of 1/1000 person-years. Conclusion This study highlights the importance of drug uptake and data availability in early post-approval drug safety surveillance in Mini-Sentinel. There is limited ability to detect rate ratios below three for events with background rates of 1/1000 person-years or lower. This is largely due to low product uptake. JF - Pharmacoepidemiology and Drug Safety AU - Mott, Katrina AU - Graham, David J AU - Toh, Sengwee AU - Gagne, Joshua J AU - Levenson, Mark AU - Ma, Yong AU - Reichman, Marsha E AD - CDER Office of Surveillance and Epidemiology, U.S. Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1023 EP - 1032 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 9 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts KW - Databases KW - Data processing KW - Statistics KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827899616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Uptake+of+new+drugs+in+the+early+post-approval+period+in+the+Mini-Sentinel+distributed+database&rft.au=Mott%2C+Katrina%3BGraham%2C+David+J%3BToh%2C+Sengwee%3BGagne%2C+Joshua+J%3BLevenson%2C+Mark%3BMa%2C+Yong%3BReichman%2C+Marsha+E&rft.aulast=Mott&rft.aufirst=Katrina&rft.date=2016-09-01&rft.volume=25&rft.issue=9&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.4013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Databases; Statistics; Data processing; Drugs DO - http://dx.doi.org/10.1002/pds.4013 ER - TY - JOUR T1 - S06-3Us cohort study of uranium miners on the colorado plateau: what new information can we learn? AN - 1827895304; PQ0003696815 AB - Since the 1950s, the U.S. Public Health Service (and subsequently the National Institute for Occupational Safety and Health) has conducted a cohort study of more than 4000 uranium miners on the Colorado Plateau (CP) in the southwest United States. These miners were obtaining raw uranium to supply the U.S. nuclear weapons industry from the 1940s to the late 1980s. Initially, researchers administered questionnaires and physical examinations among the miners (both white and American Indian), who are a subset of a much larger group of miners employed during the cold war era. Thousands of measurements were made of radon progeny in hundreds of mines over a period of decades. Since the 1970s, the CP cohort has been followed for mortality and morbidity outcomes and smoking assessment. The unique features of the CP cohort include its high doses, extensive dosimetry, near-complete smoking information, and long follow-up. The cohort has contributed extensively to knowledge of lung cancer risk from radon exposure, including understanding of inverse dose-rate effects, changes in risk with time since exposure, and the form of interaction with smoking. As of the last follow-up in 2005, 75% of the cohort was deceased. Despite the anticipation that lung cancer rates would decline in the late follow-up, published findings suggest that attributable risk of lung cancer continues to be high in the cohort, particularly for miners who smoked little or not at all. The form of interaction of radon dose with smoking appears to remain sub-multiplicative but super-additive. Outcomes other than lung cancer, such as idiopathic pulmonary fibrosis, and some forms of renal disease, have shown associations with radon exposure. With a final wave of follow-up, the CP cohort continues to provide key information to support the development of protective standards to minimise lifetime lung cancer risk from occupational radon exposure. JF - Occupational and Environmental Medicine AU - Schubauer-Berigan, Mary AU - Daniels, Robert AD - National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A103 EP - A104 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Fibrosis KW - Occupational safety KW - renal KW - Morbidity KW - Public health KW - Smoking KW - Plateaus KW - Uranium KW - Occupational exposure KW - Lung cancer KW - Inventories KW - Mortality KW - Dosimetry KW - Kidney diseases KW - Lung diseases KW - USA, Colorado Plateau KW - Mines KW - Cancer KW - Radon KW - Health risks KW - Radiation measurements KW - Progeny KW - Mining KW - X 24380:Social Poisons & Drug Abuse KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827895304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=S06-3Us+cohort+study+of+uranium+miners+on+the+colorado+plateau%3A+what+new+information+can+we+learn%3F&rft.au=Schubauer-Berigan%2C+Mary%3BDaniels%2C+Robert&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A103&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.280 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Mortality; Inventories; Fibrosis; Dosimetry; Lung diseases; Kidney diseases; Mines; Radon; Morbidity; Public health; Smoking; Uranium; Progeny; Occupational exposure; Lung cancer; Risk assessment; Occupational safety; renal; Cancer; Health risks; Plateaus; Radiation measurements; Mining; USA, Colorado Plateau DO - http://dx.doi.org/10.1136/oemed-2016-103951.280 ER - TY - JOUR T1 - O13-3Risk assessment: conventional diesel exhaust and lung cancer AN - 1827895173; PQ0003697241 AB - Studies in railroad workers, truck drivers, and miners reveal diesel exhaust to be carcinogenic. Although technology has evolved, a large capacity in the U.S and globally still comprises traditional diesel engine design in transportation, mining, construction and farming. The Diesel Exhaust in Miners Study (DEMS) with an extensive exposure assessment investigated 200 lung cancer deaths in non-coal and non-metal miners. A DEMS dataset was used to calculate the excess lifetime risk for airborne concentrations of respirable elemental carbon (REC). A healthy worker survivor effect and possible confounding by non-diesel power generation and other mining exposures (e.g., explosives) were investigated along with dose-rate effects using Poisson regression methods with high-resolution classification. Lung cancer mortality declined with employment duration and more so when REC and non diesel exposure effects were also estimated, revealing a strong survivor bias. Attenuation of the REC effect was also observed with increasing (lagged) cumulative REC exposure. In underground miners, the excess relative rate of lung cancer mortality was 0.67 (p < 0.0001) for a 10 year exposure to 200 mu g/m3 REC, a typical underground exposure. At occupational REC exposures of 200, 10 and 1 mu g/m3 the excess lifetime risks, respectively, were 119, 43 and 8.7 per thousand. The estimated lifetime risk was greater than some previous estimates not accounting for heathy worker survival bias. This bias was addressed using employment duration and mine above/below ground status. A model-fitted function of cumulative exposure accommodated attenuation of exposure effect. The estimated excess lifetime risks of lung cancer at old diesel REC exposure levels common in occupational groups in the past exceed 5%. JF - Occupational and Environmental Medicine AU - Park, Robert AD - CDC/National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A25 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Survival KW - Employment KW - Workers KW - Carbon KW - Classification KW - Occupational exposure KW - Lung cancer KW - Mortality KW - diesel exhaust* KW - Mines KW - Cancer KW - Exhausts KW - Health risks KW - Electric power generation KW - Diesel KW - Mining KW - Explosives KW - Diesel engines KW - Technology KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827895173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O13-3Risk+assessment%3A+conventional+diesel+exhaust+and+lung+cancer&rft.au=Park%2C+Robert&rft.aulast=Park&rft.aufirst=Robert&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A25&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.68 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mortality; Workers; Carbon; Classification; Survival; Diesel; Explosives; Mines; Occupational exposure; Exhausts; Lung cancer; Risk assessment; diesel exhaust*; Employment; Cancer; Health risks; Electric power generation; Mining; Diesel engines; Technology DO - http://dx.doi.org/10.1136/oemed-2016-103951.68 ER - TY - JOUR T1 - Refinement of the Nanoparticle Emission Assessment Technique into the Nanomaterial Exposure Assessment Technique (NEAT 2.0) AN - 1827895072; PQ0003699924 AB - Engineered nanomaterial emission and exposure characterization studies have been completed at more than 60 different facilities by the National Institute for Occupational Safety and Health (NIOSH). These experiences have provided NIOSH the opportunity to refine an earlier published technique, the Nanoparticle Emission Assessment Technique (NEAT 1.0), into a more comprehensive technique for assessing worker and workplace exposures to engineered nanomaterials. This change is reflected in the new name Nanomaterial Exposure Assessment Technique (NEAT 2.0) which distinguishes it from NEAT 1.0. NEAT 2.0 places a stronger emphasis on time-integrated, filter-based sampling (i.e., elemental mass analysis and particle morphology) in the worker's breathing zone (full shift and task specific) and area samples to develop job exposure matrices. NEAT 2.0 includes a comprehensive assessment of emissions at processes and job tasks, using direct-reading instruments (i.e., particle counters) in data-logging mode to better understand peak emission periods. Evaluation of worker practices, ventilation efficacy, and other engineering exposure control systems and risk management strategies serve to allow for a comprehensive exposure assessment. JF - Journal of Occupational and Environmental Hygiene AU - Eastlake, Adrienne C AU - Beaucham, Catherine AU - Martinez, Kenneth F AU - Dahm, Matthew M AU - Sparks, Christopher AU - Hodson, Laura L AU - Geraci, Charles L AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 708 EP - 717 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 9 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Particle counters KW - Ventilation KW - Respiration KW - Occupational safety KW - Particulates KW - Nanotechnology KW - Risk management KW - Workers KW - Control systems KW - Morphology KW - Emissions KW - Sampling KW - nanoparticles KW - Occupational exposure KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24300:Methods KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827895072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Refinement+of+the+Nanoparticle+Emission+Assessment+Technique+into+the+Nanomaterial+Exposure+Assessment+Technique+%28NEAT+2.0%29&rft.au=Eastlake%2C+Adrienne+C%3BBeaucham%2C+Catherine%3BMartinez%2C+Kenneth+F%3BDahm%2C+Matthew+M%3BSparks%2C+Christopher%3BHodson%2C+Laura+L%3BGeraci%2C+Charles+L&rft.aulast=Eastlake&rft.aufirst=Adrienne&rft.date=2016-09-01&rft.volume=13&rft.issue=9&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1167278 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Workers; Ventilation; Respiration; Sampling; nanoparticles; Occupational exposure; Environmental hygiene; Risk management; Particle counters; Control systems; Morphology; Occupational safety; Emissions; Particulates; Nanotechnology DO - http://dx.doi.org/10.1080/15459624.2016.1167278 ER - TY - JOUR T1 - O46-2Development of an asthma-specific job exposure matrix for use in the united states AN - 1827891163; PQ0003696763 AB - ObjectivesTo develop an asthma-specific job-exposure matrix (JEM) optimised for the United States (US).MethodsWe started with the asthma-specific N-JEM that was developed for use in northern Europe, and adapted it to reflect workplace conditions in the US and function with the 2010 Standard Occupational Classification (SOC-2010) codes, which are used widely in the US. The N-JEM functions with the 1988 International Standard Classification of Occupations (ISCO-88). Exposures assessed by the N-JEM for ISCO-88 codes were transferred to comparable SOC-2010 codes by using two cross-walks (ISCO-88 to ISCO-08 to SOC-2010). Three experts (two industrial hygienists, one epidemiologist) used the criterion of a high probability of relevant exposure for at least half the workers to delete or confirm exposure status assigned to SOC-2010 occupations, and to identify additional occupations as exposed. The experts worked independently, submitted initial decisions to the study coordinator, and discussed their decisions with the other experts before submitting final decisions. Exposure status in the JEM was based on a majority opinion of the three experts. The resulting alpha version of the new US Asthma-specific JEM (USA-JEM) was applied to current occupations in a cohort of working adults with asthma, exposures were compared to those assessed by the N-JEM, and disagreements were reviewed to consider further modifications to the USA-JEM. ResultsWe made numerous changes to N-JEM exposures assigned to SOC-2010 occupations by cross-walking from the ISCO-88 codes. Comparing exposure assessments from the two JEMs in the same cohort yielded changes for only 15 SOC-2010 detailed occupations. A total of 399 (47.5%) of the 840 SOC-2010 detailed occupations were assessed by the USA-JEM as having probable exposure to at least one of 19 types of work-related asthma agents. ConclusionsThe new USA-JEM could be a useful research tool, but further evaluation of its performance is needed. JF - Occupational and Environmental Medicine AU - Henneberger, Paul AU - Kurth, Laura AU - Doney, Brent AU - Liang, Xiaoming AU - Andersson, Eva AD - CDC/NIOSH, Morgantown, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A87 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Asthma KW - Respiratory diseases KW - International standards KW - USA KW - Classification KW - ANE, Europe KW - Reviews KW - Occupational exposure KW - International standardization KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827891163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O46-2Development+of+an+asthma-specific+job+exposure+matrix+for+use+in+the+united+states&rft.au=Henneberger%2C+Paul%3BKurth%2C+Laura%3BDoney%2C+Brent%3BLiang%2C+Xiaoming%3BAndersson%2C+Eva&rft.aulast=Henneberger&rft.aufirst=Paul&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A87&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.233 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - International standards; Classification; Reviews; Asthma; Occupational exposure; Respiratory diseases; International standardization; USA; ANE, Europe DO - http://dx.doi.org/10.1136/oemed-2016-103951.233 ER - TY - JOUR T1 - P303Exploring the role of shift work in population-based prospective cohort studies of cancer AN - 1827891012; PQ0003697190 AB - Epidemiologic evidence in humans for a link between shift work and cancer remains inconclusive, despite renewed interest in the subject subsequent to the International Agency for Research on Cancer classification of shift work involving circadian rhythm disruption as a probable carcinogen (group 2A) in 2007.In this study, we reviewed ongoing or recently completed population-based prospective cohort studies of cancer risk factors in adults to evaluate the data collected on occupation, including work schedules and shift work, and the use of these data in the assessment of cancer risk. We also recorded information collected on lifestyle factors that may be associated with cancer or modify risks associated with shift work.Fifty-three cohorts were identified using the National Cancer Institute Cohort Consortium Membership list, pooled studies that used prospective population-based cohorts, and a NIH RePORTER database search. Publications with cancer-specific outcomes were identified using publication lists on cohort websites, searches in journal databases such as PubMed and Scopus, and citation tracking from previously found publications.Questionnaires from 45 cohorts and 3,393 publications that met inclusion criteria were reviewed; principal investigators of each cohort were contacted to corroborate the information abstracted. Twenty-four cohorts collected occupational histories and thirteen have obtained information on shift work, including duration (77%), intensity (46%), and rotating shift schedules (85%). Eighteen publications from six cohorts have investigated associations between shift work and breast, ovarian, uterine, lung, colorectal, prostate, or pancreatic cancers.Relatively few reviewed studies have investigated the relationship between shift work and cancer. We are exploring opportunities to collaborate in studies by analysing existing data or by collecting information on occupation, work schedules, and shift work in studies that are still following up study participants, to further scientific knowledge of the role of shift work in cancer. JF - Occupational and Environmental Medicine AU - Carreon, Tania AU - Robinson, Susan AU - DeBono, Nathaniel AU - MacDonald, Leslie AU - Pinkerton, Lynne AD - National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A223 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - Risk assessment KW - Historical account KW - Carcinogens KW - Working conditions KW - Cancer KW - Shift work KW - Health risks KW - Classification KW - Lung KW - Risk factors KW - Circadian rhythms KW - Data bases KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827891012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=P303Exploring+the+role+of+shift+work+in+population-based+prospective+cohort+studies+of+cancer&rft.au=Carreon%2C+Tania%3BRobinson%2C+Susan%3BDeBono%2C+Nathaniel%3BMacDonald%2C+Leslie%3BPinkerton%2C+Lynne&rft.aulast=Carreon&rft.aufirst=Tania&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A223&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Risk assessment; Historical account; Health risks; Shift work; Classification; Lung; Risk factors; Circadian rhythms; Carcinogens; Data bases; Cancer; Working conditions DO - http://dx.doi.org/10.1136/oemed-2016-103951.618 ER - TY - JOUR T1 - Surface wipe sampling for antineoplastic (chemotherapy) and other hazardous drug residue in healthcare settings: Methodology and recommendations AN - 1827890899; PQ0003699920 AB - Surface wipe sampling for various hazardous agents has been employed in many occupational settings over the years for various reasons such as evaluation of potential dermal exposure and health risk, source determination, quality or cleanliness, compliance, and others. Wipe sampling for surface residue of antineoplastic and other hazardous drugs in healthcare settings is currently the method of choice to determine surface contamination of the workplace with these drugs. The purpose of this article is to review published studies of wipe sampling for antineoplastic and other hazardous drugs, to summarize the methods in use by various organizations and researchers, and to provide some basic guidance for conducting surface wipe sampling for these drugs in healthcare settings. Recommendations on wipe sampling methodology from several government agencies and organizations were reviewed. Published reports on wipe sampling for hazardous drugs in numerous studies were also examined. The critical elements of a wipe sampling program and related limitations were reviewed and summarized. Recommendations and guidance are presented concerning the purposes of wipe sampling for antineoplastic and other hazardous drugs in the healthcare setting, technical factors and variables, sampling strategy, materials required, and limitations. The reporting and interpretation of wipe sample results is also discussed. It is recommended that all healthcare settings where antineoplastic and other hazardous drugs are handled consider wipe sampling as part of a comprehensive hazardous drug "safe handling" program. Although no standards exist for acceptable or allowable surface concentrations for these drugs in the healthcare setting, wipe sampling may be used as a method to characterize potential occupational dermal exposure risk and to evaluate the effectiveness of implemented controls and the overall safety program. A comprehensive safe-handling program for antineoplastic drugs may utilize wipe sampling as a screening tool to evaluate environmental contamination and strive to reduce contamination levels as much as possible, using the industrial hygiene hierarchy of controls. JF - Journal of Occupational and Environmental Hygiene AU - Connor, Thomas H AU - Zock, Matthew D AU - Snow, Amy H AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 658 EP - 667 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Contamination KW - Residues KW - Chemotherapy KW - Compliance KW - Safety KW - Antineoplastic drugs KW - Health risks KW - Health care KW - Risk factors KW - Hygiene KW - Drugs KW - Government agencies KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827890899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Surface+wipe+sampling+for+antineoplastic+%28chemotherapy%29+and+other+hazardous+drug+residue+in+healthcare+settings%3A+Methodology+and+recommendations&rft.au=Connor%2C+Thomas+H%3BZock%2C+Matthew+D%3BSnow%2C+Amy+H&rft.aulast=Connor&rft.aufirst=Thomas&rft.date=2016-09-01&rft.volume=13&rft.issue=9&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1165912 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Health risks; Residues; Contamination; Health care; Chemotherapy; Risk factors; Safety; Compliance; Antineoplastic drugs; Hygiene; Drugs; Government agencies DO - http://dx.doi.org/10.1080/15459624.2016.1165912 ER - TY - JOUR T1 - O41-1Is beryllium-induced lung cancer caused only by soluble forms and high exposure levels? AN - 1827889805; PQ0003696740 AB - The International Agency for Research on Cancer has deemed beryllium a Group 1 lung carcinogen, based in part on findings from a pooled cohort of U.S. beryllium processing workers. The U.S. Occupational Safety and Health Administration (OSHA) recently proposed a tenfold-decreased permissible exposure limit for beryllium, based partly on estimates of lung cancer risk from recent follow-up of this pooled cohort (the only cohort available with quantitative exposure information). Criticisms in the literature and public comments hypothesise that workers hired after 1954 (when exposures were lower) or exposed only to insoluble forms of beryllium do not exhibit increased risk of lung cancer. We evaluated this hypothesis by conducting Cox proportional hazards regression analyses in age-based risk sets within two (of three) plants in the pooled cohort. 98% of workers at these plants were hired 1955-1969. We used categorical and power models to evaluate exposure-response patterns for mean and cumulative beryllium exposure in the two-plant cohort, comparing findings to published estimates from the full pooled cohort. We also evaluated the distribution of exposure-years in each cohort by solubility class (soluble, insoluble, mixed). Mean beryllium exposure averaged <2 mu g/m3 and the predominant form was insoluble, among the two-plant cohort. We observed 75 lung cancer cases (through 2005). Adjusting for confounders related to smoking and the healthy worker effect, we observed a monotonic increase in lung cancer mortality across exposure categories. The exposure-response coefficients (per unit of exposure) were 0.242 (p = 0.087) for mean exposure and 0.151 (p = 0.049) for cumulative exposure, compared to 0.155 and 0.094 (respectively) in the full cohort. The low exposure levels at these two plants and the predominance of insoluble beryllium suggest that the overall pooled cohort findings upon which OSHA's lung cancer risk assessment is based are highly relevant for current workers exposed to all forms of beryllium. JF - Occupational and Environmental Medicine AU - Schubauer-Berigan, Mary AU - Couch, James AU - Deddens, James AD - National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A79 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Safety regulations KW - Occupational safety KW - Carcinogens KW - Workers KW - Smoking KW - Dose-response effects KW - Regression analysis KW - Occupational exposure KW - Lung cancer KW - Mortality KW - Federal regulations KW - Solubility KW - Cancer KW - Health risks KW - Beryllium KW - X 24380:Social Poisons & Drug Abuse KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827889805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O41-1Is+beryllium-induced+lung+cancer+caused+only+by+soluble+forms+and+high+exposure+levels%3F&rft.au=Schubauer-Berigan%2C+Mary%3BCouch%2C+James%3BDeddens%2C+James&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A79&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.212 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Risk assessment; Smoking; Mortality; Workers; Solubility; Dose-response effects; Beryllium; Regression analysis; Carcinogens; Occupational exposure; Lung cancer; Federal regulations; Safety regulations; Occupational safety; Cancer; Health risks DO - http://dx.doi.org/10.1136/oemed-2016-103951.212 ER - TY - JOUR T1 - Vaginal progesterone decreases preterm birth less than or equal to 34weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study AN - 1827887866; PQ0003650973 AB - Objective To evaluate the efficacy of vaginal progesterone administration for preventing preterm birth and perinatal morbidity and mortality in asymptomatic women with a singleton gestation and a mid-trimester sonographic cervical length (CL) less than or equal to 25mm. Methods This was an updated systematic review and meta-analysis of randomized controlled trials comparing the use of vaginal progesterone to placebo/no treatment in women with a singleton gestation and a mid-trimester sonographic CL less than or equal to 25mm. Electronic databases, from their inception to May 2016, bibliographies and conference proceedings were searched. The primary outcome measure was preterm birth less than or equal to 34weeks of gestation or fetal death. Two reviewers independently selected studies, assessed the risk of bias and extracted the data. Pooled relative risks (RRs) with 95% confidence intervals (CI) were calculated. Results Five trials involving 974 women were included. A meta-analysis, including data from the OPPTIMUM study, showed that vaginal progesterone significantly decreased the risk of preterm birth less than or equal to 34weeks of gestation or fetal death compared to placebo (18.1% vs 27.5%; RR, 0.66 (95%CI, 0.52-0.83); P =0.0005; five studies; 974 women). Meta-analyses of data from four trials (723 women) showed that vaginal progesterone administration was associated with a statistically significant reduction in the risk of preterm birth occurring at <28 to<36 gestational weeks (RRs from 0.51 to 0.79), respiratory distress syndrome (RR, 0.47 (95%CI, 0.27-0.81)), composite neonatal morbidity and mortality (RR, 0.59 (95%CI, 0.38-0.91)), birth weight<1500g (RR, 0.52 (95%CI, 0.34-0.81)) and admission to the neonatal intensive care unit (RR, 0.67 (95%CI, 0.50-0.91)). There were no significant differences in neurodevelopmental outcomes at 2years of age between the vaginal progesterone and placebo groups. Conclusion This updated systematic review and meta-analysis reaffirms that vaginal progesterone reduces the risk of preterm birth and neonatal morbidity and mortality in women with a singleton gestation and a mid-trimester CL less than or equal to 25mm, without any deleterious effects on neurodevelopmental outcome. Clinicians should continue to perform universal transvaginal CL screening at 18-24weeks of gestation in women with a singleton gestation and to offer vaginal progesterone to those with a CL less than or equal to 25mm. This article has been selected for Journal Club. Click here to view slides and discussion points. JF - Ultrasound in Obstetrics and Gynecology AU - Romero, R AU - Nicolaides, KH AU - Conde-Agudelo, A AU - O'Brien, J M AU - Cetingoz, E AU - Da Fonseca, E AU - Creasy, G W AU - Hassan, S S AD - Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 308 EP - 317 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 48 IS - 3 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Mortality KW - Age KW - Data processing KW - Gynecology KW - Progesterone KW - Statistical analysis KW - Fetuses KW - Morbidity KW - Pregnancy KW - Intensive care units KW - Bibliographies KW - Reviews KW - Vagina KW - Gestation KW - Neonates KW - Cervix KW - Obstetrics KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827887866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Vaginal+progesterone+decreases+preterm+birth+less+than+or+equal+to+34weeks+of+gestation+in+women+with+a+singleton+pregnancy+and+a+short+cervix%3A+an+updated+meta-analysis+including+data+from+the+OPPTIMUM+study&rft.au=Romero%2C+R%3BNicolaides%2C+KH%3BConde-Agudelo%2C+A%3BO%27Brien%2C+J+M%3BCetingoz%2C+E%3BDa+Fonseca%2C+E%3BCreasy%2C+G+W%3BHassan%2C+S+S&rft.aulast=Romero&rft.aufirst=R&rft.date=2016-09-01&rft.volume=48&rft.issue=3&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.15953 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Age; Data processing; Progesterone; Gynecology; Statistical analysis; Morbidity; Fetuses; Pregnancy; Intensive care units; Bibliographies; Reviews; Gestation; Vagina; Neonates; Cervix; Ultrasound; Obstetrics DO - http://dx.doi.org/10.1002/uog.15953 ER - TY - JOUR T1 - O47-5Association of metrics of peak exposure with beryllium sensitisation AN - 1827886466; PQ0003696773 AB - Interday or intraday high-intensity exposures (i.e., exposure peaks) may be more relevant for initiating beryllium sensitisation (BeS); such exposures may exceed a threshold necessary to activate the immune response. This study evaluated the relationships of exposure metrics reflecting normal process variation and upset conditions with the prevalence of BeS.In a study of workers employed from 1994-1999 at a primary beryllium manufacturing facility, exposure metrics were developed using personal full-shift measurement, 15 minutes to 24 hour process-specific area measurements, and process-upset information gleaned from historical reports. Quantitative intensity metrics included highest-ever job-specific average, maximum, 95th percentile, upper tolerance limit (UTL), exceedance fractions (>0.2 and >2 mu g/m3), and the product of the geometric mean and geometric standard deviation (GMxGSD). Qualitative metrics included professional judgment of process-upsets (PJPU), and number of process-upset events (e.g., power outage). Relationships among these metrics were evaluated using Spearman correlation and their association with BeS was evaluated using logistic regression with splined and log-transformed exposures.As anticipated, a high degree of correlation existed among metrics within full-shift measurements (rS: 0.57-0.99) and task/process measurements (rS: 0.56-0.96), and moderate correlation across the two measurement types (rS: 0.48-0.79). Most of these metrics were associated with BeS in logistic models of log-transformed exposures. In splined models, non-linear associations were observed with average, 95th percentile, UTL, and exceedance fraction > 2 mu g/m3 from the personal samples. Strong associations with BeS were observed for GMxGSD (OR = 1.8 and 3.6) and PJPU (OR = 8.3 and 8.5) for medium and high categories compared to low category. Professional judgments regarding process-upset potential and the combined GMxGSD were valuable in predicting BeS; each may reflect a different aspect of interday and intraday exposure peaks. Non-linear associations were possibly due to confounding by chemical form and/or skin exposure, use of respiratory protection, presence of a threshold and/or by genetic susceptibility. JF - Occupational and Environmental Medicine AU - Virji, Mohammed Abbas AU - Schuler, Christine AU - Stanton, Marcia AU - Kent, Michael AU - Stefaniak, Alexandr AD - NIOSH, Morgantown, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A90 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Manufacturing industry KW - Skin KW - Electricity KW - Models KW - Standard deviation KW - Information processing KW - Beryllium KW - Immune response KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827886466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O47-5Association+of+metrics+of+peak+exposure+with+beryllium+sensitisation&rft.au=Virji%2C+Mohammed+Abbas%3BSchuler%2C+Christine%3BStanton%2C+Marcia%3BKent%2C+Michael%3BStefaniak%2C+Alexandr&rft.aulast=Virji&rft.aufirst=Mohammed&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A90&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.242 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Standard deviation; Skin; Information processing; Beryllium; Immune response; Occupational exposure; Models; Manufacturing industry; Historical account; Electricity DO - http://dx.doi.org/10.1136/oemed-2016-103951.242 ER - TY - JOUR T1 - O13-1An exploratory risk assessment for metalworking fluids (MWFS) AN - 1827885773; PQ0003697236 AB - MWF mixtures vary across manufacturing process, facilities, enterprises and over time. The routes of exposure are dermal in liquid phase, and inhalation as dusts, mists and vapours. The challenge is to generalise from specific worker populations observed over many decades and from animal studies limited to few priority components. Cancer risks have been observed in both hazard identification and exposure-response studies. Respiratory disorders and performance deficits are other health effects of MWFs appearing as increased morbidity and mortality or reduced pulmonary function, as well as immune-mediated disorders: adult-onset asthma and hypersensitivity pneumonitis (HP). Dermatitis has been a constant associate of MWFs for more than two centuries. The goal here was to explore the development of a generic summary of MWF effects to determine exposure levels conferring an acceptable low level of risk in most metalworking environments. Only total gravimetric measures of airborne dusts or mists were considered, usually with restriction to the respirable fraction. Aggregate cancer excess risk was estimated from the few studies with adequate retrospective exposure assessments and work history. Lifetime risk was calculated. Annual proportional loss of respiratory capacity was evaluated, using a benchmark dose procedure. Incidence of asthma and hypersensitivity pneumonitis (HP) was examined as were aggregate symptoms focusing largely on respiratory complaints. For MWF exposure to 0.1 mg/m3 over 45 yr, the lifetime risk of attributable cancer was about 3.5% and attributable respiratory impairment would occur in 4.5% of workers. Lifetime risk of asthma or HP (under outbreak conditions) was 80% at 0.1 mg/m3. After 45 yr at 0.1 mg/m3 MWF, excess prevalence of primarily respiratory symptoms would be 9 percent based on published studies, and 20 percent from NIOSH investigations. JF - Occupational and Environmental Medicine AU - Park, Robert AD - CDC/National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A25 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Inhalation KW - Respiratory diseases KW - Morbidity KW - Dust KW - Workers KW - Hypersensitivity KW - Dose-response effects KW - Risk factors KW - Respiratory function KW - Occupational exposure KW - Dermatitis KW - Mortality KW - Skin KW - Asthma KW - Cancer KW - Health risks KW - Lung KW - Priorities KW - Benchmarks KW - Alveolitis KW - X 24360:Metals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827885773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=O13-1An+exploratory+risk+assessment+for+metalworking+fluids+%28MWFS%29&rft.au=Park%2C+Robert&rft.aulast=Park&rft.aufirst=Robert&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A25&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.66 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Inhalation; Risk assessment; Mortality; Skin; Asthma; Cancer; Dust; Morbidity; Workers; Lung; Risk factors; Dose-response effects; Alveolitis; Occupational exposure; Dermatitis; Respiratory diseases; Health risks; Hypersensitivity; Priorities; Respiratory function; Benchmarks DO - http://dx.doi.org/10.1136/oemed-2016-103951.66 ER - TY - JOUR T1 - Effective dust control systems on concrete dowel drilling machinery AN - 1827885738; PQ0003699927 AB - Rotary-type percussion dowel drilling machines, which drill horizontal holes in concrete pavement, have been documented to produce respirable crystalline silica concentrations above recommended exposure criteria. This places operators at potential risk for developing health effects from exposure. United States manufacturers of these machines offer optional dust control systems. The effectiveness of the dust control systems to reduce respirable dust concentrations on two types of drilling machines was evaluated under controlled conditions with the machines operating inside large tent structures in an effort to eliminate secondary exposure sources not related to the dowel-drilling operation. Area air samples were collected at breathing zone height at three locations around each machine. Through equal numbers of sampling rounds with the control systems randomly selected to be on or off, the control systems were found to significantly reduce respirable dust concentrations from a geometric mean of 54 mg per cubic meter to 3.0 mg per cubic meter on one machine and 57 mg per cubic meter to 5.3 mg per cubic meter on the other machine. This research shows that the dust control systems can dramatically reduce respirable dust concentrations by over 90% under controlled conditions. However, these systems need to be evaluated under actual work conditions to determine their effectiveness in reducing worker exposures to crystalline silica below hazardous levels. JF - Journal of Occupational and Environmental Hygiene AU - Echt, Alan S AU - Sanderson, Wayne T AU - Mead, Kenneth R AU - Feng, HAmy AU - Farwick, Daniel R AU - Farwick, Dawn Ramsey AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2016/09/01/ PY - 2016 DA - 2016 Sep 01 SP - 718 EP - 724 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 9 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - USA KW - Silica KW - Control systems KW - Machinery KW - Air sampling KW - Dust KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827885738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Effective+dust+control+systems+on+concrete+dowel+drilling+machinery&rft.au=Echt%2C+Alan+S%3BSanderson%2C+Wayne+T%3BMead%2C+Kenneth+R%3BFeng%2C+HAmy%3BFarwick%2C+Daniel+R%3BFarwick%2C+Dawn+Ramsey&rft.aulast=Echt&rft.aufirst=Alan&rft.date=2016-09-01&rft.volume=13&rft.issue=9&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1177644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Silica; Control systems; Machinery; Air sampling; Occupational exposure; Dust; USA DO - http://dx.doi.org/10.1080/15459624.2016.1177644 ER - TY - JOUR T1 - P026Using cancer registry data and job exposure matrices for occupational cancer surveillance AN - 1827885614; PQ0003696894 AB - Cancer is the second leading cause of death in the US, accounting for 1 out of 4 deaths, and cancer incidence is over two-fold higher compared to cancer mortality. Occupational exposures are an important cancer risk factor, exceeded only by tobacco consumption, and infectious disease. However, it is estimated that only less than 2% of chemicals in commerce have been tested for carcinogenicity. In addition, many workers are exposed to multiple carcinogens at low levels, and the effect of exposure to these mixtures is unknown. Therefore, despite progress in understanding cancer aetiology, much is still unknown about the role played by work and workplace exposures. Without a better understanding of the occupational role in cancer aetiology, targeting public health interventions is fraught with difficulty. In October 2015 NIOSH began developing a multistate population-based occupational cancer surveillance system utilising cancer registry data from six states (California, Iowa, Kentucky, Massachusetts, New Hampshire, and Texas), and creating job exposure matrices (JEMs) for use with the cancer registry data. The occupational cancer surveillance system will be used to identify occupational cancer risks, and to explore dose-response relationships using JEMs. It builds upon the successes of a NIOSH pilot initiative begun in 2007 with the California Cancer Registry. By the end of the project in 2019, it is estimated that 3.8 million cancer cases from the six participating states will be available for analysis. For each of these cases, NIOSH will have information on their longest held job (i.e. industry and occupation titles and corresponding codes, and JEM scores for at least four exposures). This presentation will provide the latest findings from the NIOSH occupational cancer surveillance project. JF - Occupational and Environmental Medicine AU - Calvert, Geoffrey AD - NIOSH/CDC, Cincinnati, USA Y1 - 2016/09// PY - 2016 DA - September 2016 SP - A128 EP - A129 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 73 IS - Suppl 1 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Pilots KW - Intervention KW - Carcinogens KW - Public health KW - ASW, USA, Texas KW - Infectious diseases KW - Carcinogenicity KW - INE, USA, California KW - Dose-response effects KW - Risk factors KW - Tobacco KW - USA, New Hampshire KW - Occupational exposure KW - Mortality KW - USA, Massachusetts KW - Data processing KW - Cancer KW - Health risks KW - USA, Kentucky KW - USA, Iowa KW - X 24380:Social Poisons & Drug Abuse KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827885614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=P026Using+cancer+registry+data+and+job+exposure+matrices+for+occupational+cancer+surveillance&rft.au=Calvert%2C+Geoffrey&rft.aulast=Calvert&rft.aufirst=Geoffrey&rft.date=2016-09-01&rft.volume=73&rft.issue=Suppl+1&rft.spage=A128&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2016-103951.351 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Infectious diseases; Carcinogenicity; Risk factors; Dose-response effects; Tobacco; Carcinogens; Occupational exposure; Cancer; Public health; Chemicals; Pilots; Intervention; Health risks; ASW, USA, Texas; USA, Massachusetts; USA, Kentucky; USA, Iowa; INE, USA, California; USA, New Hampshire DO - http://dx.doi.org/10.1136/oemed-2016-103951.351 ER - TY - JOUR T1 - DNA-PK Deficiency in Alzheimer's Disease. AN - 1826718927; 27376156 AB - Alzheimer's disease (AD) is characterized by neuronal death with an accumulaton of intra-cellular neurofibrillary tangles (NFT) and extracellular amyloid plaques. Reduced DNA repair ability has been reported in AD brains. In neurons, the predominant mechanism to repair double-strand DNA breaks (DSB) is non-homologous end joining (NHEJ) that requires DNA-dependent protein kinase (DNA-PK) activity. DNA-PK is a holoenzyme comprising the p460 kD DNA-PK catalytic subunit (DNA-PKcs) and its activator Ku, a heterodimer of p86 (Ku80) and p70 (Ku70) subunits. Upon binding to double-stranded DNA ends, Ku recruits DNA-PKcs to process NHEJ. In AD brains, reduced NHEJ activity as well as DNA-PKcs and Ku protein levels have been shown. Normal aging brains also show a reduction in both DNA-PKcs and Ku levels questioning a direct link between NHEJ ability and AD, and suggesting additional players/events in AD pathogenesis. Deficiency of Ku80, a somatostatin receptor, can disrupt somatostatin signaling thus inducing amyloid beta (Aβ) generation, which in turn can potentiate DNA-PKcs degradation and consequently loss of NHEJ activity, an additional step negatively affecting DSB repair. Trigger of these two different pathways culminating in genome instability may differentiate the outcomes between AD and normal aging. JF - Journal of neurology & neuromedicine AU - Kanungo, Jyotshna AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 17 EP - 22 VL - 1 IS - 3 KW - DNA Break KW - Ku KW - Alzheimer’s Disease KW - DNA-PK KW - NHEJ UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826718927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurology+%26+neuromedicine&rft.atitle=DNA-PK+Deficiency+in+Alzheimer%27s+Disease.&rft.au=Kanungo%2C+Jyotshna&rft.aulast=Kanungo&rft.aufirst=Jyotshna&rft.date=2016-09-01&rft.volume=1&rft.issue=3&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurology+%26+neuromedicine&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Getting the most out of PubChem for virtual screening. AN - 1825220259; 27454129 AB - With the emergence of the 'big data' era, the biomedical research community has great interest in exploiting publicly available chemical information for drug discovery. PubChem is an example of public databases that provide a large amount of chemical information free of charge. This article provides an overview of how PubChem's data, tools, and services can be used for virtual screening and reviews recent publications that discuss important aspects of exploiting PubChem for drug discovery. PubChem offers comprehensive chemical information useful for drug discovery. It also provides multiple programmatic access routes, which are essential to build automated virtual screening pipelines that exploit PubChem data. In addition, PubChemRDF allows users to download PubChem data and load them into a local computing facility, facilitating data integration between PubChem and other resources. PubChem resources have been used in many studies for developing bioactivity and toxicity prediction models, discovering polypharmacologic (multi-target) ligands, and identifying new macromolecule targets of compounds (for drug-repurposing or off-target side effect prediction). These studies demonstrate the usefulness of PubChem as a key resource for computer-aided drug discovery and related area. JF - Expert opinion on drug discovery AU - Kim, Sunghwan AD - a National Center for Biotechnology Information, National Library of Medicine , National Institutes of Health , Department of Health and Human Services, Bethesda , MD , USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 843 EP - 855 VL - 11 IS - 9 KW - Index Medicus KW - data mining KW - biological assay KW - cheminformatics KW - polypharmacology KW - computer-aided drug discovery KW - computational toxicology KW - PubChem KW - quantitative structure-activity relationship (QSAR) KW - database KW - virtual screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1825220259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+discovery&rft.atitle=Getting+the+most+out+of+PubChem+for+virtual+screening.&rft.au=Kim%2C+Sunghwan&rft.aulast=Kim&rft.aufirst=Sunghwan&rft.date=2016-09-01&rft.volume=11&rft.issue=9&rft.spage=843&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+discovery&rft.issn=1746-045X&rft_id=info:doi/10.1080%2F17460441.2016.1216967 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/17460441.2016.1216967 ER - TY - JOUR T1 - Observation-based blended projections from ensembles of regional climate models AN - 1819147407; PQ0003618172 AB - We consider the problem of projecting future climate from ensembles of regional climate model (RCM) simulations using results from the North American Regional Climate Change Assessment Program (NARCCAP). To this end, we develop a hierarchical Bayesian space-time model that quantifies the discrepancies between different members of an ensemble of RCMs corresponding to present day conditions, and observational records. Discrepancies are then propagated into the future to obtain high resolution blended projections of 21st century climate. In addition to blended projections, the proposed method provides location-dependent comparisons between the different simulations by estimating the different modes of spatial variability, and using the climate model-specific coefficients of the spatial factors for comparisons. The approach has the flexibility to provide projections at customizable scales of potential interest to stakeholders while accounting for the uncertainties associated with projections at these scales based on a comprehensive statistical framework. We demonstrate the methodology with simulations from the Weather Research & Forecasting regional model (WRF) using three different boundary conditions. We use simulations for two time periods: current climate conditions, covering 1971 to 2000, and future climate conditions under the Special Report on Emissions Scenarios (SRES) A2 emissions scenario, covering 2041 to 2070. We investigate and project yearly mean summer and winter temperatures for a domain in the South West of the United States. JF - Climatic Change AU - Salazar, Esther AU - Hammerling, Dorit AU - Wang, Xia AU - Sanso, Bruno AU - Finley, Andrew O AU - Mearns, Linda O AD - U.S. Food and Drug Administration, Center for Tobacco Products, Silver Spring, MD, USA, bruno@ams.ucsc.edu Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 55 EP - 69 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 138 IS - 1-2 SN - 0165-0009, 0165-0009 KW - Pollution Abstracts; Environment Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Oceanic Abstracts; Water Resources Abstracts; Meteorological & Geoastrophysical Abstracts KW - Prediction KW - Variability KW - Climate change KW - Summer KW - Regional climates KW - Boundary conditions KW - Winter temperatures KW - Winter KW - Spatial variations KW - Emissions KW - Forecasting KW - Regional climate models KW - Weather forecasting KW - Spatial variability KW - Modelling KW - Weather KW - Climate models KW - Simulation Analysis KW - Boundary Conditions KW - Climates KW - Climate KW - Temperature KW - Simulation KW - Methodology KW - USA KW - Air pollution forecasting KW - Numerical simulations KW - Regional-scale models KW - Future climates KW - Q5 08503:Characteristics, behavior and fate KW - P 0000:AIR POLLUTION KW - M2 551.583:Variations (551.583) KW - SW 0810:General KW - O 4080:Pollution - Control and Prevention KW - ENA 20:Weather Modification & Geophysical Change UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819147407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Climatic+Change&rft.atitle=Observation-based+blended+projections+from+ensembles+of+regional+climate+models&rft.au=Salazar%2C+Esther%3BHammerling%2C+Dorit%3BWang%2C+Xia%3BSanso%2C+Bruno%3BFinley%2C+Andrew+O%3BMearns%2C+Linda+O&rft.aulast=Salazar&rft.aufirst=Esther&rft.date=2016-09-01&rft.volume=138&rft.issue=1-2&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Climatic+Change&rft.issn=01650009&rft_id=info:doi/10.1007%2Fs10584-016-1722-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Number of references - 26 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Spatial variations; Prediction; Climate change; Climate; Weather forecasting; Methodology; Modelling; Climate models; Numerical simulations; Regional-scale models; Regional climates; Regional climate models; Winter temperatures; Boundary conditions; Spatial variability; Future climates; Weather; Air pollution forecasting; Temperature; Emissions; Simulation; Summer; Winter; Variability; Boundary Conditions; Simulation Analysis; Climates; Forecasting; USA DO - http://dx.doi.org/10.1007/s10584-016-1722-1 ER - TY - JOUR T1 - Ensemble survival trees for identifying subpopulations in personalized medicine. AN - 1817027829; 27073016 AB - Recently, personalized medicine has received great attention to improve safety and effectiveness in drug development. Personalized medicine aims to provide medical treatment that is tailored to the patient's characteristics such as genomic biomarkers, disease history, etc., so that the benefit of treatment can be optimized. Subpopulations identification is to divide patients into several different subgroups where each subgroup corresponds to an optimal treatment. For two subgroups, traditionally the multivariate Cox proportional hazards model is fitted and used to calculate the risk score when outcome is survival time endpoint. Median is commonly chosen as the cutoff value to separate patients. However, using median as the cutoff value is quite subjective and sometimes may be inappropriate in situations where data are imbalanced. Here, we propose a novel tree-based method that adopts the algorithm of relative risk trees to identify subgroup patients. After growing a relative risk tree, we apply k-means clustering to group the terminal nodes based on the averaged covariates. We adopt an ensemble Bagging method to improve the performance of a single tree since it is well known that the performance of a single tree is quite unstable. A simulation study is conducted to compare the performance between our proposed method and the multivariate Cox model. The applications of our proposed method to two public cancer data sets are also conducted for illustration. © Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Biometrical journal. Biometrische Zeitschrift AU - Chen, Yu-Chuan AU - Chen, James J AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. jamesJ.chen@fda.hhs.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1151 EP - 1163 VL - 58 IS - 5 KW - Index Medicus KW - Ensemble method KW - Subgroup identification KW - Cox proportional hazards model KW - Survival trees KW - Personalized medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1817027829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+journal.+Biometrische+Zeitschrift&rft.atitle=Ensemble+survival+trees+for+identifying+subpopulations+in+personalized+medicine.&rft.au=Chen%2C+Yu-Chuan%3BChen%2C+James+J&rft.aulast=Chen&rft.aufirst=Yu-Chuan&rft.date=2016-09-01&rft.volume=58&rft.issue=5&rft.spage=1151&rft.isbn=&rft.btitle=&rft.title=Biometrical+journal.+Biometrische+Zeitschrift&rft.issn=1521-4036&rft_id=info:doi/10.1002%2Fbimj.201500075 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bimj.201500075 ER - TY - JOUR T1 - Cooking Coal Use and All-Cause and Cause-Specific Mortality in a Prospective Cohort Study of Women in Shanghai, China. AN - 1816630804; 27091488 AB - Nearly 4.3 million deaths worldwide were attributable to exposure to household air pollution in 2012. However, household coal use remains widespread. We investigated the association of cooking coal and all-cause and cause-specific mortality in a prospective cohort of primarily never-smoking women in Shanghai, China. A cohort of 74,941 women were followed from 1996 through 2009 with annual linkage to the Shanghai vital statistics database. Cause-specific mortality was identified through 2009. Use of household coal for cooking was assessed through a residential history questionnaire. Cox proportional hazards models estimated the risk of mortality associated with household coal use. In this cohort, 63% of the women ever used coal (n = 46,287). Compared with never coal use, ever use of coal was associated with mortality from all causes [hazard ratio (HR) = 1.12; 95% confidence interval (CI): 1.05, 1.21], cancer (HR = 1.14; 95% CI: 1.03, 1.27), and ischemic heart disease (overall HR = 1.61; 95% CI: 1.14, 2.27; HR for myocardial infarction specifically = 1.80; 95% CI: 1.16, 2.79). The risk of cardiovascular mortality increased with increasing duration of coal use, compared with the risk in never users. The association between coal use and ischemic heart disease mortality diminished with increasing years since cessation of coal use. Evidence from this study suggests that past use of coal among women in Shanghai is associated with excess all-cause mortality, and from cardiovascular diseases in particular. The decreasing association with cardiovascular mortality as the time since last use of coal increased emphasizes the importance of reducing use of household coal where use is still widespread. Kim C, Seow WJ, Shu XO, Bassig BA, Rothman N, Chen BE, Xiang YB, Hosgood HD III, Ji BT, Hu W, Wen C, Chow WH, Cai Q, Yang G, Gao YT, Zheng W, Lan Q. 2016. Cooking coal use and all-cause and cause-specific mortality in a prospective cohort study of women in Shanghai, China. Environ Health Perspect 124:1384-1389; http://dx.doi.org/10.1289/EHP236. JF - Environmental health perspectives AU - Kim, Christopher AU - Seow, Wei Jie AU - Shu, Xiao-Ou AU - Bassig, Bryan A AU - Rothman, Nathaniel AU - Chen, Bingshu E AU - Xiang, Yong-Bing AU - Hosgood, H Dean AU - Ji, Bu-Tian AU - Hu, Wei AU - Wen, Cuiju AU - Chow, Wong-Ho AU - Cai, Qiuyin AU - Yang, Gong AU - Gao, Yu-Tang AU - Zheng, Wei AU - Lan, Qing AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1384 EP - 1389 VL - 124 IS - 9 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816630804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cooking+Coal+Use+and+All-Cause+and+Cause-Specific+Mortality+in+a+Prospective+Cohort+Study+of+Women+in+Shanghai%2C+China.&rft.au=Kim%2C+Christopher%3BSeow%2C+Wei+Jie%3BShu%2C+Xiao-Ou%3BBassig%2C+Bryan+A%3BRothman%2C+Nathaniel%3BChen%2C+Bingshu+E%3BXiang%2C+Yong-Bing%3BHosgood%2C+H+Dean%3BJi%2C+Bu-Tian%3BHu%2C+Wei%3BWen%2C+Cuiju%3BChow%2C+Wong-Ho%3BCai%2C+Qiuyin%3BYang%2C+Gong%3BGao%2C+Yu-Tang%3BZheng%2C+Wei%3BLan%2C+Qing&rft.aulast=Kim&rft.aufirst=Christopher&rft.date=2016-09-01&rft.volume=124&rft.issue=9&rft.spage=1384&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2FEHP236 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/EHP236 ER - TY - JOUR T1 - Post-9/11 cancer incidence in World Trade Center-exposed New York City firefighters as compared to a pooled cohort of firefighters from San Francisco, Chicago and Philadelphia (9/11/2001-2009). AN - 1816629159; 27582474 AB - BACKGROUND We previously reported a modest excess of cancer in World Trade Center (WTC)-exposed firefighters versus the general population. This study aimed to separate the potential carcinogenic effects of firefighting and WTC exposure by comparing to a cohort of non-WTC-exposed firefighters. METHODS Relative rates (RRs) for all cancers combined and individual cancer subtypes from 9/11/2001 to 12/31/2009 were modeled using Poisson regression comparing 11,457 WTC-exposed firefighters to 8,220 urban non-WTC-exposed firefighters. RESULTS Compared with non-WTC-exposed firefighters, there was no difference in the RR of all cancers combined for WTC-exposed firefighters (RR = 0.96, 95%CI: 0.83-1.12). Thyroid cancer was significantly elevated (RR = 3.82, 95%CI: 1.07-20.81) from 2001 to 2009; this was attenuated (RR = 3.43, 95%CI: 0.94-18.94) and non-significant when controlling for possible surveillance bias. Prostate cancer was elevated during the latter half (2005-2009; RR = 1.38, 95%CI: 1.01-1.88). CONCLUSIONS Further follow-up is needed to assess the relationship between WTC exposure and cancers with longer latency periods. Am. J. Ind. Med. 59:722-730, 2016. © 2016 Wiley Periodicals, Inc. JF - American journal of industrial medicine AU - Moir, William AU - Zeig-Owens, Rachel AU - Daniels, Robert D AU - Hall, Charles B AU - Webber, Mayris P AU - Jaber, Nadia AU - Yiin, James H AU - Schwartz, Theresa AU - Liu, Xiaoxue AU - Vossbrinck, Madeline AU - Kelly, Kerry AU - Prezant, David J AD - Department of Medicine, Montefiore Medical Center, Bronx, New York. ; Education and Information Division, National Institute for Occupational Safety and Health, Cincinnati, Ohio. ; Division of Biostatistics, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York. ; Bureau of Health Services, Fire Department of the City of New York, Brooklyn, New York. ; Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 722 EP - 730 VL - 59 IS - 9 KW - Index Medicus KW - firefighters KW - epidemiology KW - World Trade Center (WTC) KW - environmental disaster KW - cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816629159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+industrial+medicine&rft.atitle=Post-9%2F11+cancer+incidence+in+World+Trade+Center-exposed+New+York+City+firefighters+as+compared+to+a+pooled+cohort+of+firefighters+from+San+Francisco%2C+Chicago+and+Philadelphia+%289%2F11%2F2001-2009%29.&rft.au=Moir%2C+William%3BZeig-Owens%2C+Rachel%3BDaniels%2C+Robert+D%3BHall%2C+Charles+B%3BWebber%2C+Mayris+P%3BJaber%2C+Nadia%3BYiin%2C+James+H%3BSchwartz%2C+Theresa%3BLiu%2C+Xiaoxue%3BVossbrinck%2C+Madeline%3BKelly%2C+Kerry%3BPrezant%2C+David+J&rft.aulast=Moir&rft.aufirst=William&rft.date=2016-09-01&rft.volume=59&rft.issue=9&rft.spage=722&rft.isbn=&rft.btitle=&rft.title=American+journal+of+industrial+medicine&rft.issn=1097-0274&rft_id=info:doi/10.1002%2Fajim.22635 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-01 N1 - Date revised - 2017-02-16 N1 - Last updated - 2017-02-16 DO - http://dx.doi.org/10.1002/ajim.22635 ER - TY - JOUR T1 - Development of a quality instrument for assessing the spontaneous reports of ADR/ADE using Delphi method in China AN - 1815707704; PQ0003588739 AB - The frequently low quality of submitted spontaneous reports is of an increasing concern; to our knowledge, no validated instrument exists for assessing case reports' quality comprehensively enough. This work was conducted to develop such a quality instrument for assessing the spontaneous reports of adverse drug reaction (ADR)/adverse drug event (ADE) in China. Initial evaluation indicators were generated using systematic and literature data analysis. Final indicators and their weights were identified using Delphi method. The final quality instrument was developed by adopting the synthetic scoring method. A consensus was reached after four rounds of Delphi survey. The developed quality instrument consisted of 6 first-rank indicators, 18 second-rank indicators, and 115 third-rank indicators, and each rank indicator has been weighted. It evaluates the quality of spontaneous reports of ADR/ADE comprehensively and quantitatively on six parameters: authenticity, duplication, regulatory, completeness, vigilance level, and reporting time frame. The developed instrument was tested with good reliability and validity, which can be used to comprehensively and quantitatively assess the submitted spontaneous reports of ADR/ADE in China. JF - European Journal of Clinical Pharmacology AU - Chen, Lixun AU - Jiang, Ling AU - Shen, Aizong AU - Wei, Wei AD - Zhejiang Food and Drug Administration, Hangzhou, China, chenlixun@outlook.com Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1135 EP - 1142 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 72 IS - 9 SN - 0031-6970, 0031-6970 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Case reports KW - Vigilance KW - Drugs KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815707704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Pharmacology&rft.atitle=Development+of+a+quality+instrument+for+assessing+the+spontaneous+reports+of+ADR%2FADE+using+Delphi+method+in+China&rft.au=Chen%2C+Lixun%3BJiang%2C+Ling%3BShen%2C+Aizong%3BWei%2C+Wei&rft.aulast=Chen&rft.aufirst=Lixun&rft.date=2016-09-01&rft.volume=72&rft.issue=9&rft.spage=1135&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Pharmacology&rft.issn=00316970&rft_id=info:doi/10.1007%2Fs00228-016-2081-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 22 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Data processing; Case reports; Vigilance; Drugs DO - http://dx.doi.org/10.1007/s00228-016-2081-6 ER - TY - JOUR T1 - Evaluation of sampling methods for toxicological testing of indoor air particulate matter. AN - 1815368857; 27569522 AB - There is a need for toxicity tests capable of recognizing indoor environments with compromised air quality, especially in the context of moisture damage. One of the key issues is sampling, which should both provide meaningful material for analyses and fulfill requirements imposed by practitioners using toxicity tests for health risk assessment. We aimed to evaluate different existing methods of sampling indoor particulate matter (PM) to develop a suitable sampling strategy for a toxicological assay. During three sampling campaigns in moisture-damaged and non-damaged school buildings, we evaluated one passive and three active sampling methods: the Settled Dust Box (SDB), the Button Aerosol Sampler, the Harvard Impactor and the National Institute for Occupational Safety and Health (NIOSH) Bioaerosol Cyclone Sampler. Mouse RAW264.7 macrophages were exposed to particle suspensions and cell metabolic activity (CMA), production of nitric oxide (NO) and tumor necrosis factor (TNFα) were determined after 24 h of exposure. The repeatability of the toxicological analyses was very good for all tested sampler types. Variability within the schools was found to be high especially between different classrooms in the moisture-damaged school. Passively collected settled dust and PM collected actively with the NIOSH Sampler (Stage 1) caused a clear response in exposed cells. The results suggested the higher relative immunotoxicological activity of dust from the moisture-damaged school. The NIOSH Sampler is a promising candidate for the collection of size-fractionated PM to be used in toxicity testing. The applicability of such sampling strategy in grading moisture damage severity in buildings needs to be developed further in a larger cohort of buildings. JF - Inhalation toxicology AU - Tirkkonen, Jenni AU - Täubel, Martin AU - Hirvonen, Maija-Riitta AU - Leppänen, Hanna AU - Lindsley, William G AU - Chen, Bean T AU - Hyvärinen, Anne AU - Huttunen, Kati AD - a Department of Environmental Science , University of Eastern Finland , Kuopio , Finland . ; c National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Morgantown , WV , USA. ; b Department of Health Protection , Living Environment and Health Unit, National Institute for Health and Welfare , Kuopio , Finland , and. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 500 EP - 507 VL - 28 IS - 11 KW - Index Medicus KW - toxicity testing KW - moisture damage KW - particulate matter KW - sampling KW - Indoor air KW - in vitro UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815368857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Evaluation+of+sampling+methods+for+toxicological+testing+of+indoor+air+particulate+matter.&rft.au=Tirkkonen%2C+Jenni%3BT%C3%A4ubel%2C+Martin%3BHirvonen%2C+Maija-Riitta%3BLepp%C3%A4nen%2C+Hanna%3BLindsley%2C+William+G%3BChen%2C+Bean+T%3BHyv%C3%A4rinen%2C+Anne%3BHuttunen%2C+Kati&rft.aulast=Tirkkonen&rft.aufirst=Jenni&rft.date=2016-09-01&rft.volume=28&rft.issue=11&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958378.2016.1210702 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/08958378.2016.1210702 ER - TY - JOUR T1 - A Randomized Controlled Trial of POWER: An Internet-Based HIV Prevention Intervention for Black Bisexual Men AN - 1813587853 AB - POWER is a theory-based, on-line HIV prevention intervention developed specifically for Black men who have sex with men and women (BMSMW), an understudied group significantly impacted by HIV. To test its efficacy, we recruited 224 BMSMW using chain referral methods and randomly assigned 108 to POWER and 103 to a health information comparison condition. Three months after the intervention, participants assigned to POWER had lower odds of reporting any condomless vaginal or condomless anal intercourse (CVAI) compared to those in the comparison group (aOR = 0.49; 95 % CI 0.25-0.98; p = 0.044). The intervention was associated with significantly lower odds of condomless anal intercourse with male partners (aOR = 0.55; 95 % CI 0.34-0.91; p = 0.020) but not with female partners and serodiscordant sex with male partners but not with female partners. Future studies are needed to replicate these findings in larger and more diverse samples of BMSMW and to understand the underlying mechanisms through which intervention efficacy was achieved. JF - AIDS and Behavior AU - Fernandez, M Isabel AU - Hosek, Sybil G AU - Hotton, Anna L AU - Gaylord, Sanford E AU - Hernandez, Nilda AU - Alfonso, Sarah V AU - Joseph, Heather AD - Behavioral Health Promotion Program, College of Osteopathic Medicine, Nova Southeastern University, Miami, FL, USA ; Department of Psychiatry, Stroger Hospital of Cook County, Chicago, IL, USA ; Division of Epidemiology and Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, IL, USA ; Regional Resource Network Program, US Department of Health and Human Services, Region V, Chicago, IL, USA ; Centers for Disease Control and Prevention, Atlanta, GA, USA ; Behavioral Health Promotion Program, College of Osteopathic Medicine, Nova Southeastern University, Miami, FL, USA Y1 - 2016/09// PY - 2016 DA - Sep 2016 SP - 1951 EP - 1960 CY - New York PB - Springer Science & Business Media VL - 20 IS - 9 SN - 1090-7165 KW - Psychology KW - BMSMW KW - HIV prevention KW - Interventions KW - Sexual behavior KW - Acquired Immune Deficiency Syndrome KW - Intervention KW - Prevention KW - Homosexuality KW - Methodology (Data Collection) KW - Sexual Intercourse KW - Bisexuality KW - Internet KW - Power KW - 6129:addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1813587853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=A+Randomized+Controlled+Trial+of+POWER%3A+An+Internet-Based+HIV+Prevention+Intervention+for+Black+Bisexual+Men&rft.au=Fernandez%2C+M+Isabel%3BHosek%2C+Sybil+G%3BHotton%2C+Anna+L%3BGaylord%2C+Sanford+E%3BHernandez%2C+Nilda%3BAlfonso%2C+Sarah+V%3BJoseph%2C+Heather&rft.aulast=Fernandez&rft.aufirst=M&rft.date=2016-09-01&rft.volume=20&rft.issue=9&rft.spage=1951&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-016-1403-0 LA - English DB - Social Services Abstracts N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-12-07 DO - http://dx.doi.org/10.1007/s10461-016-1403-0 ER - TY - JOUR T1 - A Model to predict severity of drug-induced liver injury in humans. AN - 1812881614; 27302180 AB - Drug-induced liver injury (DILI) is a major public health concern, and improving its prediction remains an unmet challenge. Recently, we reported the Rule-of-2 (RO2) and found lipophilicity (logP ≥3) and daily dose ≥100 mg of oral medications to be associated with significant risk for DILI; however, the RO2 failed to estimate grades of DILI severity. In an effort to develop a quantitative metrics, we analyzed the association of daily dose, logP, and formation of reactive metabolites (RM) in a large set of Food and Drug Administration-approved oral medications and found factoring RM into the RO2 to highly improve DILI prediction. Based on these parameters and by considering n = 354 drugs, an algorithm to assign a DILI score was developed. In univariate and multivariate logistic regression analyses the algorithm (i.e., DILI score model) defined the relative contribution of daily dose, logP, and RM and permitted a quantitative assessment of risk of clinical DILI. Furthermore, a clear relationship between calculated DILI scores and DILI risk was obtained when applied to three independent studies. The DILI score model was also functional with drug pairs defined by similar chemical structure and mode of action but divergent toxicities. Specifically, for drug pairs where the RO2 failed, the DILI score correctly identified toxic drugs. Finally, the model was applied to n = 159 clinical cases collected from the National Institutes of Health's LiverTox database to demonstrate that the DILI score correlated with the severity of clinical outcome. Based on daily dose, lipophilicity, and RM, a DILI score algorithm was developed that provides a scale of assessing the severity of DILI risk in humans associated with oral medications. (Hepatology 2016;64:931-940). © 2016 by the American Association for the Study of Liver Diseases. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. JF - Hepatology (Baltimore, Md.) AU - Chen, Minjun AU - Borlak, Jürgen AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR. ; Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 931 EP - 940 VL - 64 IS - 3 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812881614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=A+Model+to+predict+severity+of+drug-induced+liver+injury+in+humans.&rft.au=Chen%2C+Minjun%3BBorlak%2C+J%C3%BCrgen%3BTong%2C+Weida&rft.aulast=Chen&rft.aufirst=Minjun&rft.date=2016-09-01&rft.volume=64&rft.issue=3&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/10.1002%2Fhep.28678 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/hep.28678 ER - TY - JOUR T1 - Differentiating parts of Cinnamomum cassia using LC-qTOF-MS in conjunction with principal component analysis AN - 1811881422; PQ0003549777 AB - Cinnamon bark (Rou Gui in Chinese), cinnamon twig (Gui Zhi) and shaved cinnamon bark (Gui Sin) have been widely used as spices and in traditional Chinese medicine since ancient times. On-going issues related to quality and authenticity necessitate the development of analytical methods capable of providing an objective evaluation of samples. In this study, chemical fingerprints of cinnamon bark, cinnamon twigs and shaved cinnamon bark were established using liquid chromatography quadruple time-of-flight mass spectrometry in conjunction with principal component analysis (PCA). From 125 samples of cinnamon, we identified the following eight compounds and their the detection ratios: coumarin, cinnamaldehyde, cinnamyl alcohol, cinnamic acid, 2-hydroxycinnamaldehyde, 2-hydroxycinnamic acid, 2-methoxycinnamaldehyde and 4-methoxycinnamaldehyde. Of these, 4-methoxycinnamaldehyde presented the largest variations in detection ratio, making up 64.0, 97.4 and 50.0% in cinnamon bark, cinnamon twig, and shaved cinnamon bark, respectively. The quantities of cinnamyl alcohol, coumarin and cinnamaldehyde also varied between the three parts of the plant. Chemical fingerprints of the three cinnamon samples were established using principal component analysis, the results of which indicate that cinnamon bark and shaved cinnamon bark could be easily differentiated, despite a marked similarity in outward appearance. Cinnamon twig was also shown to depart from the other clusters. The proposed method provides a fast and efficient means of identifying cinnamon herbs for quality control purposes. JF - Biomedical Chromatography AU - Chen, Pei-Yi AU - Yu, Jhe-Wei AU - Lu, Fen-Ling AU - Lin, Mei-Chih AU - Cheng, Hwei-Fang AD - Division of Research and Analysis, Food and Drug Administration, Ministry of Health and Welfare, Taiwan, Republic of China. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1449 EP - 1457 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 30 IS - 9 SN - 0269-3879, 0269-3879 KW - Biotechnology and Bioengineering Abstracts KW - cinnamon KW - cinnamaldehyde KW - Spices KW - Bark KW - Traditional Chinese Medicine KW - Cinnamic acid KW - Mass spectroscopy KW - Liquid chromatography KW - Cinnamomum KW - Quality control KW - Principal components analysis KW - Coumarin KW - alcohols KW - Herbs KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811881422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+Chromatography&rft.atitle=Differentiating+parts+of+Cinnamomum+cassia+using+LC-qTOF-MS+in+conjunction+with+principal+component+analysis&rft.au=Chen%2C+Pei-Yi%3BYu%2C+Jhe-Wei%3BLu%2C+Fen-Ling%3BLin%2C+Mei-Chih%3BCheng%2C+Hwei-Fang&rft.aulast=Chen&rft.aufirst=Pei-Yi&rft.date=2016-09-01&rft.volume=30&rft.issue=9&rft.spage=1449&rft.isbn=&rft.btitle=&rft.title=Biomedical+Chromatography&rft.issn=02693879&rft_id=info:doi/10.1002%2Fbmc.3703 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - cinnamon; cinnamaldehyde; Spices; Bark; Mass spectroscopy; Cinnamic acid; Traditional Chinese Medicine; Liquid chromatography; Principal components analysis; Quality control; Coumarin; alcohols; Herbs; Cinnamomum DO - http://dx.doi.org/10.1002/bmc.3703 ER - TY - JOUR T1 - Teratogenic drugs and their drug interactions with hormonal contraceptives. AN - 1811300188; 27090193 AB - The US Food and Drug Administration (FDA) Guidance for Industry-Drug Interaction Studies, recommends that a potential human teratogen needs to be studied in vivo for effects on contraceptive steroids.(1) This article highlights the need to evaluate the drug-drug interactions (DDIs) between drugs with teratogenic potential and hormonal contraceptives (HCs) during drug development. It also addresses the FDA's effort of communicating DDI findings in product labels to mitigate the risk of unintended pregnancy. © 2016 ASCPT. JF - Clinical pharmacology and therapeutics AU - Ahn, M R AU - Li, L AU - Shon, J AU - Bashaw, E D AU - Kim, M-J AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 217 EP - 219 VL - 100 IS - 3 KW - Abridged Index Medicus KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811300188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Teratogenic+drugs+and+their+drug+interactions+with+hormonal+contraceptives.&rft.au=Ahn%2C+M+R%3BLi%2C+L%3BShon%2C+J%3BBashaw%2C+E+D%3BKim%2C+M-J&rft.aulast=Ahn&rft.aufirst=M&rft.date=2016-09-01&rft.volume=100&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1002%2Fcpt.384 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cpt.384 ER - TY - JOUR T1 - In vivo activation of a T helper 2-driven innate immune response in lung fibrosis induced by multi-walled carbon nanotubes. AN - 1811296975; 27106021 AB - Pulmonary exposure to certain forms of carbon nanotubes (CNT) induces fibrosing lesions in the lungs that manifest an acute inflammation followed by chronic interstitial fibrosis. The mechanism of CNT-induced fibrogenesis is largely unknown. The biphasic development with drastically distinct pathologic manifestations suggests a junction of acute-to-chronic transition. Here we analyzed the molecular pathways and regulators underlying the pathologic development of CNT-induced lung fibrosis. Mice were exposed to multi-walled CNT (MWCNT; XNRI MWNT-7, Mitsui; 40 μg) by pharyngeal aspiration for 7 days along with vehicle and carbonaceous controls. Genome-wide microarray analyses of the lungs identified a range of differentially expressed genes that potentially function in the acute-to-chronic transition through pathways involving immune and inflammatory regulation, responses to stress and extracellular stimuli, and cell migration and adhesion. In particular, a T helper 2 (Th2)-driven innate immune response was significantly enriched. We then demonstrated that MWCNT induced the expression of Th2 cytokines interleukin (IL)-4 and IL-13, and a panel of signature downstream genes, such as Il4i1, Chia, and Ccl11/Eotaxin, time dependently. Induction of Th2 cytokines took place in CD4+ T lymphocytes indicating activation of Th2 cells. Furthermore, induction involved activation of a Th2 cell-specific signaling pathway through phosphorylation of STAT6 and up-regulation of GATA-3 to mediate the transcription of Th2 target genes. Our study uncovers activation of a Th2-driven immune/inflammatory response during pulmonary fibrosis development induced by MWCNT. The findings provide novel insights into the molecular events that control the transition from an acute inflammatory response to chronic fibrosis through Th2 functions in CNT-exposed lungs. JF - Archives of toxicology AU - Dong, Jie AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, 1095 Willowdale Road, Morgantown, WV, 26505, USA. ; Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, 1095 Willowdale Road, Morgantown, WV, 26505, USA. qam1@cdc.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 2231 EP - 2248 VL - 90 IS - 9 KW - Index Medicus KW - Pulmonary fibrosis KW - Th2-type response KW - IL-13 KW - Multi-walled carbon nanotubes KW - IL-4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811296975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=In+vivo+activation+of+a+T+helper+2-driven+innate+immune+response+in+lung+fibrosis+induced+by+multi-walled+carbon+nanotubes.&rft.au=Dong%2C+Jie%3BMa%2C+Qiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2016-09-01&rft.volume=90&rft.issue=9&rft.spage=2231&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-016-1711-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-13 N1 - Date revised - 2017-02-09 N1 - Last updated - 2017-02-09 DO - http://dx.doi.org/10.1007/s00204-016-1711-1 ER - TY - JOUR T1 - Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women. AN - 1809599839; 27255803 AB - Urine and serum biomonitoring was used to measure internal exposure to selected dietary estrogens in a cohort of 30 pregnant women. Exposure was measured over a period comprising one-half day in the field (6 h) and one day in a clinic (24 h). Biomonitoring of the dietary phytoestrogens genistein (GEN), daidzein (DDZ) and equol (EQ), as well as the mycoestrogen, zearalenone (ZEN) and its congeners, was conducted using UPLC-MS/MS. Biomonitoring revealed evidence of internal exposure to naturally occurring dietary estrogens during pregnancy. Urinary concentrations of total GEN, DDZ and EQ were similar to levels reported for general adult U.S. Measurable concentrations of total (parent and metabolites) GEN, DDZ and EQ were present in 240, 207 and 2 of 270 serum samples, respectively. Six out of 30 subjects had measurable concentrations of unconjugated GEN and/or DDZ in serum between 0.6 and 7.1 nM. Urine to serum total isoflavone ratios for GEN, DDZ and EQ were 13, 47, and 180, respectively. ZEN and its reductive metabolite, α-zearalenol (α-ZEL), were present in pregnant women (11 out of 30 subjects) as conjugates at levels near the limit of quantification. The average total urinary concentration was 0.10 μg/L for ZEN and 0.11 μg/L for α-ZEL. Copyright © 2016. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Fleck, Stefanie C AU - Churchwell, Mona I AU - Doerge, Daniel R AU - Teeguarden, Justin G AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: stefanie.fleck@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: mona.churchwell@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: daniel.doerge@fda.hhs.gov. ; Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99352, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 93771, USA. Electronic address: jt@pnnl.gov. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 19 EP - 27 VL - 95 KW - Index Medicus KW - Zearalenone KW - Soy isoflavones KW - Exposure KW - Endocrine disruptors KW - Biomonitoring KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809599839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Urine+and+serum+biomonitoring+of+exposure+to+environmental+estrogens+II%3A+Soy+isoflavones+and+zearalenone+in+pregnant+women.&rft.au=Fleck%2C+Stefanie+C%3BChurchwell%2C+Mona+I%3BDoerge%2C+Daniel+R%3BTeeguarden%2C+Justin+G&rft.aulast=Fleck&rft.aufirst=Stefanie&rft.date=2016-09-01&rft.volume=95&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.05.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.05.021 ER - TY - JOUR T1 - Association of MHC region SNPs with irritant susceptibility in healthcare workers. AN - 1809046673; 27258892 AB - Irritant contact dermatitis is the most common work-related skin disease, especially affecting workers in "wet-work" occupations. This study was conducted to investigate the association between single nucleotide polymorphisms (SNPs) within the major histocompatibility complex (MHC) and skin irritant response in a group of healthcare workers. 585 volunteer healthcare workers were genotyped for MHC SNPs and patch tested with three different irritants: sodium lauryl sulfate (SLS), sodium hydroxide (NaOH) and benzalkonium chloride (BKC). Genotyping was performed using Illumina Goldengate MHC panels. A number of SNPs within the MHC Class I (OR2B3, TRIM31, TRIM10, TRIM40 and IER3), Class II (HLA-DPA1, HLA-DPB1) and Class III (C2) genes were associated (p < 0.001) with skin response to tested irritants in different genetic models. Linkage disequilibrium patterns and functional annotations identified two SNPs in the TRIM40 (rs1573298) and HLA-DPB1 (rs9277554) genes, with a potential impact on gene regulation. In addition, SNPs in PSMB9 (rs10046277 and ITPR3 (rs499384) were associated with hand dermatitis. The results are of interest as they demonstrate that genetic variations in inflammation-related genes within the MHC can influence chemical-induced skin irritation and may explain the connection between inflamed skin and propensity to subsequent allergic contact sensitization. JF - Journal of immunotoxicology AU - Yucesoy, Berran AU - Talzhanov, Yerkebulan AU - Michael Barmada, M AU - Johnson, Victor J AU - Kashon, Michael L AU - Baron, Elma AU - Wilson, Nevin W AU - Frye, Bonnie AU - Wang, Wei AU - Fluharty, Kara AU - Gharib, Rola AU - Meade, Jean AU - Germolec, Dori AU - Luster, Michael I AU - Nedorost, Susan AD - a Health Effects Laboratory Division , CDC/NIOSH , Morgantown , WV , USA ; ; b Department of Human Genetics, Graduate School of Public Health , University of Pittsburgh , Pittsburgh , PA , USA ; ; c BRT-Burleson Research Technologies , Morrisville , NC , USA ; ; d University Hospitals Case Medical Center, Case Western Reserve University , Cleveland , OH , USA ; ; e Department of Pediatrics, School of Medicine , University of Nevada , Reno , NV , USA ; ; f Department of Dermatology, School of Medicine , West Virginia University , Morgantown , WV , USA ; ; g Office of Director, CDC/NIOSH , Morgantown , WV , USA ; ; h Toxicology Branch, DNTP/NIEHS, Research Triangle Park , NC , USA ; ; i School of Public Health, West Virginia University , Morgantown , WV , USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 738 EP - 744 VL - 13 IS - 5 KW - Index Medicus KW - Genetics KW - healthcare workers KW - irritant contact dermatitis KW - MHC UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809046673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Association+of+MHC+region+SNPs+with+irritant+susceptibility+in+healthcare+workers.&rft.au=Yucesoy%2C+Berran%3BTalzhanov%2C+Yerkebulan%3BMichael+Barmada%2C+M%3BJohnson%2C+Victor+J%3BKashon%2C+Michael+L%3BBaron%2C+Elma%3BWilson%2C+Nevin+W%3BFrye%2C+Bonnie%3BWang%2C+Wei%3BFluharty%2C+Kara%3BGharib%2C+Rola%3BMeade%2C+Jean%3BGermolec%2C+Dori%3BLuster%2C+Michael+I%3BNedorost%2C+Susan&rft.aulast=Yucesoy&rft.aufirst=Berran&rft.date=2016-09-01&rft.volume=13&rft.issue=5&rft.spage=738&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.3109%2F1547691X.2016.1173135 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-03 N1 - Date revised - 2017-02-06 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.3109/1547691X.2016.1173135 ER - TY - JOUR T1 - Cytokine release: A workshop proceedings on the state-of-the-science, current challenges and future directions. AN - 1804867467; 27309676 AB - In October 2013, the International Life Sciences Institute - Health and Environmental Sciences Institute Immunotoxicology Technical Committee (ILSI-HESI ITC) held a one-day workshop entitled, "Workshop on Cytokine Release: State-of-the-Science, Current Challenges and Future Directions". The workshop brought together scientists from pharmaceutical, academic, health authority, and contract research organizations to discuss novel approaches and current challenges for the use of in vitro cytokine release assays (CRAs) for the identification of cytokine release syndrome (CRS) potential of novel monoclonal antibody (mAb) therapeutics. Topics presented encompassed a regulatory perspective on cytokine release and assessment, case studies regarding the translatability of preclinical cytokine data to the clinic, and the latest state of the science of CRAs, including comparisons between mAb therapeutics within one platform and across several assay platforms, a novel physiological assay platform, and assay optimization approaches such as determination of FcR expression profiles and use of statistical tests. The data and approaches presented confirmed that multiple CRA platforms are in use for identification of CRS potential and that the choice of a particular CRA platform is highly dependent on the availability of resources for individual laboratories (e.g. positive and negative controls, number of human blood donors), the assay through-put required, and the mechanism-of-action of the therapeutic candidate to be tested. Workshop participants agreed that more data on the predictive performance of CRA platforms is needed, and current efforts to compare in vitro assay results with clinical cytokine assessments were discussed. In summary, many laboratories continue to focus research efforts on the improvement of the translatability of current CRA platforms as well explore novel approaches which may lead to more accurate, and potentially patient-specific, CRS prediction in the future. Copyright © 2016. Published by Elsevier Ltd. JF - Cytokine AU - Grimaldi, Christine AU - Finco, Deborah AU - Fort, Madeline M AU - Gliddon, Daniel AU - Harper, Kirsty AU - Helms, Whitney S AU - Mitchell, Jane A AU - O'Lone, Raegan AU - Parish, Stanley T AU - Piche, Marie-Soleil AU - Reed, Daniel M AU - Reichmann, Gabriele AU - Ryan, Patricia C AU - Stebbings, Richard AU - Walker, Mindi AD - Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA. ; Pfizer Inc., 1 Eastern Point Road, Groton, CT 06340, USA. ; Amgen, Inc., Comparative Biology and Safety Sciences, USA. ; Envigo, Woolley Road, Alconbury, Huntingdon, Cambridgeshire PE28 4HS, United Kingdom. ; US Food and Drug Administration, 10903 New Hampshire Ave, Rockville, MD, USA. ; Imperial College London, London SW3 6LY, United Kingdom. ; ILSI Health and Environmental Sciences Institute, 1156 15th St NW, Suite 200, Washington, DC 20005, USA. ; ILSI Health and Environmental Sciences Institute, 1156 15th St NW, Suite 200, Washington, DC 20005, USA. Electronic address: sparish@hesiglobal.org. ; Charles River Laboratories, 20222 Transcanadien, Senneville, QC H9X 3R3, Canada. ; Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Paul-Ehrlich Str. 51-59, 63225 Langen, Germany. ; Medimmune, Inc., One MedImmune Way, Gaithersburg, MD 20878, USA. ; The National Institute of Biological Standards and Controls, Blanche Ln, South Mimms, Potters Bar EN6 3QG, United Kingdom. ; Johnson and Johnson, Inc., 1 Johnson and Johnson Plaza, New Brunswick, NJ 08933, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 101 EP - 108 VL - 85 KW - Index Medicus KW - Cytokine release syndrome KW - Pro-inflammatory cytokines KW - Cytokine release assay UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1804867467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Cytokine+release%3A+A+workshop+proceedings+on+the+state-of-the-science%2C+current+challenges+and+future+directions.&rft.au=Grimaldi%2C+Christine%3BFinco%2C+Deborah%3BFort%2C+Madeline+M%3BGliddon%2C+Daniel%3BHarper%2C+Kirsty%3BHelms%2C+Whitney+S%3BMitchell%2C+Jane+A%3BO%27Lone%2C+Raegan%3BParish%2C+Stanley+T%3BPiche%2C+Marie-Soleil%3BReed%2C+Daniel+M%3BReichmann%2C+Gabriele%3BRyan%2C+Patricia+C%3BStebbings%2C+Richard%3BWalker%2C+Mindi&rft.aulast=Grimaldi&rft.aufirst=Christine&rft.date=2016-09-01&rft.volume=85&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=1096-0023&rft_id=info:doi/10.1016%2Fj.cyto.2016.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cyto.2016.06.006 ER - TY - JOUR T1 - Integrated decision strategies for skin sensitization hazard. AN - 1804855247; 26851134 AB - One of the top priorities of the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVAM) is the identification and evaluation of non-animal alternatives for skin sensitization testing. Although skin sensitization is a complex process, the key biological events of the process have been well characterized in an adverse outcome pathway (AOP) proposed by the Organisation for Economic Co-operation and Development (OECD). Accordingly, ICCVAM is working to develop integrated decision strategies based on the AOP using in vitro, in chemico and in silico information. Data were compiled for 120 substances tested in the murine local lymph node assay (LLNA), direct peptide reactivity assay (DPRA), human cell line activation test (h-CLAT) and KeratinoSens assay. Data for six physicochemical properties, which may affect skin penetration, were also collected, and skin sensitization read-across predictions were performed using OECD QSAR Toolbox. All data were combined into a variety of potential integrated decision strategies to predict LLNA outcomes using a training set of 94 substances and an external test set of 26 substances. Fifty-four models were built using multiple combinations of machine learning approaches and predictor variables. The seven models with the highest accuracy (89-96% for the test set and 96-99% for the training set) for predicting LLNA outcomes used a support vector machine (SVM) approach with different combinations of predictor variables. The performance statistics of the SVM models were higher than any of the non-animal tests alone and higher than simple test battery approaches using these methods. These data suggest that computational approaches are promising tools to effectively integrate data sources to identify potential skin sensitizers without animal testing. Published 2016. This article has been contributed to by US Government employees and their work is in the public domain in the USA. Published 2016. This article has been contributed to by US Government employees and their work is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Strickland, Judy AU - Zang, Qingda AU - Kleinstreuer, Nicole AU - Paris, Michael AU - Lehmann, David M AU - Choksi, Neepa AU - Matheson, Joanna AU - Jacobs, Abigail AU - Lowit, Anna AU - Allen, David AU - Casey, Warren AD - ILS, Research Triangle Park, North Carolina, 27709, USA. ; EPA/NHEERL/EPHD/CIB, Research Triangle Park, North Carolina, 27709, USA. ; U.S. Consumer Product Safety Commission, Bethesda, Maryland, 20814, USA. ; FDA/CDER, Silver Spring, Maryland, 20993, USA. ; EPA/OCSPP/OPP/HED, Washington, District of Columbia, 20460, USA. ; NIH/NIEHS/DNTP/NICEATM, Research Triangle Park, North Carolina, 27709, USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1150 EP - 1162 VL - 36 IS - 9 KW - Index Medicus KW - support vector machine KW - skin sensitization KW - machine learning KW - LLNA KW - DPRA KW - h-CLAT KW - KeratinoSens KW - integrated decision strategy KW - allergic contact dermatitis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1804855247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Integrated+decision+strategies+for+skin+sensitization+hazard.&rft.au=Strickland%2C+Judy%3BZang%2C+Qingda%3BKleinstreuer%2C+Nicole%3BParis%2C+Michael%3BLehmann%2C+David+M%3BChoksi%2C+Neepa%3BMatheson%2C+Joanna%3BJacobs%2C+Abigail%3BLowit%2C+Anna%3BAllen%2C+David%3BCasey%2C+Warren&rft.aulast=Strickland&rft.aufirst=Judy&rft.date=2016-09-01&rft.volume=36&rft.issue=9&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3281 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-14 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1002/jat.3281 ER - TY - JOUR T1 - Polygonumnolides C1-C4; minor dianthrone glycosides from the roots of Polygonum multiflorum Thunb. AN - 1802736760; 27139982 AB - Four new dianthrone glycosides, named polygonumnolides C1-C4 (1-4), were isolated from the dried roots of Polygonum multiflorum Thunb, together with two known emodin dianthrones (5-6). Their hepatotoxicities were evaluated against L-02 cell lines. Compounds 1-4 showed weak hepatotoxicity against L-02 cell lines with IC50 values of 313.05, 205.20, 294.20, and 207.35 μM, respectively. JF - Journal of Asian natural products research AU - Yang, Jian-Bo AU - Li, Li AU - Dai, Zhong AU - Wu, Yu AU - Geng, Xing-Chao AU - Li, Bo AU - Ma, Shuang-Cheng AU - Wang, Ai-Guo AU - Su, Ya-Lun AD - a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China. ; b National Institutes for Food and Drug Control, China Food and Drug Administration , Beijing 100050 , China. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 813 EP - 822 VL - 18 IS - 9 KW - Anthracenes KW - 0 KW - Drugs, Chinese Herbal KW - Glycosides KW - Emodin KW - KA46RNI6HN KW - Index Medicus KW - polygonumnolides C1–C4 KW - dianthrone glycosides KW - Polygonum multiflorum KW - L-02 cell lines KW - Molecular Structure KW - Emodin -- chemistry KW - Stereoisomerism KW - Nuclear Magnetic Resonance, Biomolecular KW - Humans KW - Plant Roots -- chemistry KW - Drugs, Chinese Herbal -- chemistry KW - Anthracenes -- isolation & purification KW - Glycosides -- isolation & purification KW - Anthracenes -- chemistry KW - Glycosides -- chemistry KW - Liver -- drug effects KW - Drugs, Chinese Herbal -- isolation & purification KW - Polygonum -- chemistry KW - Drugs, Chinese Herbal -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802736760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Asian+natural+products+research&rft.atitle=Polygonumnolides+C1-C4%3B+minor+dianthrone+glycosides+from+the+roots+of+Polygonum+multiflorum+Thunb.&rft.au=Yang%2C+Jian-Bo%3BLi%2C+Li%3BDai%2C+Zhong%3BWu%2C+Yu%3BGeng%2C+Xing-Chao%3BLi%2C+Bo%3BMa%2C+Shuang-Cheng%3BWang%2C+Ai-Guo%3BSu%2C+Ya-Lun&rft.aulast=Yang&rft.aufirst=Jian-Bo&rft.date=2016-09-01&rft.volume=18&rft.issue=9&rft.spage=813&rft.isbn=&rft.btitle=&rft.title=Journal+of+Asian+natural+products+research&rft.issn=1477-2213&rft_id=info:doi/10.1080%2F10286020.2016.1171758 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-03 N1 - Date created - 2016-07-07 N1 - Date revised - 2017-02-07 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1080/10286020.2016.1171758 ER - TY - JOUR T1 - Assessing the protection of the nanomaterial workforce. AN - 1793569167; 26865347 AB - Responsible development of any technology, including nanotechnology, requires protecting workers, the first people to be exposed to the products of the technology. In the case of nanotechnology, this is difficult to achieve because in spite of early evidence raising health and safety concerns, there are uncertainties about hazards and risks. The global response to these concerns has been the issuance by authoritative agencies of precautionary guidance to strictly control exposures to engineered nanomaterials (ENMs). This commentary summarizes discussions at the "Symposium on the Health Protection of Nanomaterial Workers" held in Rome (25 and 26 February 2015). There scientists and practitioners from 11 countries took stock of what is known about hazards and risks resulting from exposure to ENMs, confirmed that uncertainties still exist, and deliberated on what it would take to conduct a global assessment of how well workers are being protected from potentially harmful exposures. JF - Nanotoxicology AU - Schulte, Paul A AU - Iavicoli, Ivo AU - Rantanen, Jorma H AU - Dahmann, Dirk AU - Iavicoli, Sergio AU - Pipke, Rüdiger AU - Guseva Canu, Irina AU - Boccuni, Fabio AU - Ricci, Maximo AU - Polci, Maria Letizia AU - Sabbioni, Enrico AU - Pietroiusti, Antonio AU - Mantovani, Elvio AD - a Education and Information Division , Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH) , Cincinnati , OH , USA . ; b Department of Public Health , University of Naples Federico II , Naples , Italy . ; c International Commission on Occupational Health (ICOH) , Hyvinkää , Finland . ; d Institute for the Research on Hazardous Substances (IGF) , Bochum , Germany . ; e Department of Occupational and Environmental Medicine , Epidemiology and Hygiene, Italian Workers' Compensation Authority (INAIL) , Rome , Italy . ; f Federal Institute for Occupational Safety and Health (BAuA) , Dortmund , Germany . ; g Department of Occupational Health , French Institute for Public Health Surveillance, Occupational Health Department , St. Maurice , France . ; h SHO-NANO , Campana , Argentina . ; i Italian Ministry of Health , Rome , Italy . ; j Italian Society of Nanotoxicology , Rome , Italy . ; k Department of Biomedicine and Prevention , University of Rome Tor Vergata , Rome , Italy , and. ; l Italian Association for Industrial Research (AIRI) , Rome , Italy. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 1013 EP - 1019 VL - 10 IS - 7 KW - Index Medicus KW - occupational exposure limits KW - precautionary guidance KW - toxicity KW - Control procedures UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793569167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Assessing+the+protection+of+the+nanomaterial+workforce.&rft.au=Schulte%2C+Paul+A%3BIavicoli%2C+Ivo%3BRantanen%2C+Jorma+H%3BDahmann%2C+Dirk%3BIavicoli%2C+Sergio%3BPipke%2C+R%C3%BCdiger%3BGuseva+Canu%2C+Irina%3BBoccuni%2C+Fabio%3BRicci%2C+Maximo%3BPolci%2C+Maria+Letizia%3BSabbioni%2C+Enrico%3BPietroiusti%2C+Antonio%3BMantovani%2C+Elvio&rft.aulast=Schulte&rft.aufirst=Paul&rft.date=2016-09-01&rft.volume=10&rft.issue=7&rft.spage=1013&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2015.1132347 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/17435390.2015.1132347 ER - TY - JOUR T1 - Evaluation of the effect of valence state on cerium oxide nanoparticle toxicity following intratracheal instillation in rats. AN - 1793567125; 26898289 AB - Cerium (Ce) is becoming a popular metal for use in electrochemical applications. When in the form of cerium oxide (CeO2), Ce can exist in both 3 + and 4 + valence states, acting as an ideal catalyst. Previous in vitro and in vivo evidence have demonstrated that CeO2 has either anti- or pro-oxidant properties, possibly due to the ability of the nanoparticles to transition between valence states. Therefore, we chose to chemically modify the nanoparticles to shift the valence state toward 3+. During the hydrothermal synthesis process, 10 mol% gadolinium (Gd) and 20 mol% Gd, were substituted into the lattice of the CeO2 nanoparticles forming a perfect solid solution with various A-site valence states. These two Gd-doped CeO2 nanoparticles were compared to pure CeO2 nanoparticles. Preliminary characteristics indicated that doping results in minimal size and zeta potential changes but alters valence state. Following characterization, male Sprague-Dawley rats were exposed to 0.5 or 1.0 mg/kg nanoparticles via a single intratracheal instillation. Animals were sacrificed and bronchoalveolar lavage fluid and various tissues were collected to determine the effect of valence state and oxygen vacancies on toxicity 1-, 7-, or 84-day post-exposure. Results indicate that damage, as measured by elevations in lactate dehydrogenase, occurred within 1-day post-exposure and was sustained 7-day post-exposure, but subsided to control levels 84-day post-exposure. Furthermore, no inflammatory signaling or lipid peroxidation occurred following exposure with any of the nanoparticles. Our results implicate that valence state has a minimal effect on CeO2 nanoparticle toxicity in vivo. JF - Nanotoxicology AU - Dunnick, Katherine M AU - Morris, Anna M AU - Badding, Melissa A AU - Barger, Mark AU - Stefaniak, Aleksandr B AU - Sabolsky, Edward M AU - Leonard, Stephen S AD - a HELD , National Institute for Occupational Safety and Health , Morgantown , WV , USA . ; c RHD , National Institute for Occupational Safety and Health , Morgantown , WV , USA , and. ; d WVU Benjamin M. Statler College of Engineering and Mineral Resources , Morgantown , WV , USA. Y1 - 2016/09// PY - 2016 DA - September 2016 SP - 992 EP - 1000 VL - 10 IS - 7 KW - Index Medicus KW - intratracheal instillation KW - Cerium oxide KW - nanotoxicity KW - valence state KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793567125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Evaluation+of+the+effect+of+valence+state+on+cerium+oxide+nanoparticle+toxicity+following+intratracheal+instillation+in+rats.&rft.au=Dunnick%2C+Katherine+M%3BMorris%2C+Anna+M%3BBadding%2C+Melissa+A%3BBarger%2C+Mark%3BStefaniak%2C+Aleksandr+B%3BSabolsky%2C+Edward+M%3BLeonard%2C+Stephen+S&rft.aulast=Dunnick&rft.aufirst=Katherine&rft.date=2016-09-01&rft.volume=10&rft.issue=7&rft.spage=992&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2016.1157220 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Mol Sci. 2014;15(4):6072-85 [24727375] Biol Trace Elem Res. 2015 Jul;166(1):96-107 [25778836] Biomed Pharmacother. 2015 Jul;73:80-6 [26211586] J Exp Med. 2003 May 5;197(9):1107-17 [12719479] Chest. 1983 May;83(5):780-3 [6839821] Occup Environ Med. 1994 Mar;51(3):195-9 [8130849] Am J Ind Med. 1995 Mar;27(3):349-58 [7747741] Regul Toxicol Pharmacol. 1995 Feb;21(1):123-35 [7784625] Fundam Appl Toxicol. 1995 Nov;28(1):65-70 [8566485] Int J Toxicol. 2006 Nov-Dec;25(6):451-7 [17132603] Biomaterials. 2007 Apr;28(10):1918-25 [17222903] Toxicology. 2008 Mar 12;245(1-2):90-100 [18243471] ACS Nano. 2008 Oct 28;2(10):2121-34 [19206459] Toxicol Lett. 2009 Jun 1;187(2):77-83 [19429248] Nanotechnology. 2010 Jul 16;21(28):285103 [20562477] Nanomedicine. 2010 Oct;6(5):698-705 [20172051] Crit Rev Toxicol. 2011 Mar;41(3):213-29 [21244219] ScientificWorldJournal. 2011;11:801-25 [21479351] ACS Nano. 2011 Jun 28;5(6):4537-49 [21612305] Toxicol Lett. 2011 Aug 28;205(2):105-15 [21624445] Nanotoxicology. 2011 Sep;5(3):312-25 [20925443] Int J Nanomedicine. 2011;6:2327-35 [22072870] Toxicol Appl Pharmacol. 2012 Aug 1;262(3):255-64 [22613087] PLoS One. 2012;7(8):e42656 [22880072] Nanotoxicology. 2013 Dec;7(8):1338-50 [23061914] Nanotoxicology. 2014 Nov;8(7):786-98 [23914771] Toxicol Appl Pharmacol. 2015 Oct 1;288(1):63-73 [26210349] Arch Toxicol. 2016 Feb;90(2):269-78 [25618551] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/17435390.2016.1157220 ER - TY - JOUR T1 - Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells. AN - 1811294643; 27320055 AB - Designer drugs such as synthetic psychostimulants are indicative of a worldwide problem of drug abuse and addiction. In addition to methamphetamine (METH), these drugs include 3,4-methylenedioxy-methamphetamine (MDMA) and commercial preparations of synthetic cathinones including 3,4-methylenedioxypyrovalerone (MDPV), typically referred to as "bath salts." These psychostimulants exert neurotoxic effects by altering monoamine systems in the brain. Additionally, METH and MDMA adversely affect the integrity of the blood-brain barrier (BBB): there are no current reports on the effects of MDPV on the BBB. The aim of this study was to compare the effects of METH, MDMA and MDPV on bovine brain microvessel endothelial cells (bBMVECs), an accepted in vitro model of the BBB. Confluent bBMVEC monolayers were treated with METH, MDMA and MDPV (0.5mM-2.5mM) for 24h. METH and MDMA increased lactate dehydrogenase release only at the highest concentration (2.5mM), whereas MDPV induced cytotoxicity at all concentrations. MDMA and METH decreased cellular proliferation only at 2.5mM, with similar effects observed after MDPV exposures starting at 1mM. Only MDPV increased reactive oxygen species production at all concentrations tested whereas all 3 drugs increased nitric oxide production. Morphological analysis revealed different patterns of compound-induced cell damage. METH induced vacuole formation at 1mM and disruption of the monolayer at 2.5mM. MDMA induced disruption of the endothelial monolayer from 1mM without vacuolization. On the other hand, MDPV induced monolayer disruption at doses ≥0.5mM without vacuole formation; at 2.5mM, the few remaining cells lacked endothelial morphology. These data suggest that even though these synthetic psychostimulants alter monoaminergic systems, they each induce BBB toxicity by different mechanisms with MDPV being the most toxic. Published by Elsevier Ireland Ltd. JF - Neuroscience letters AU - Rosas-Hernandez, Hector AU - Cuevas, Elvis AU - Lantz, Susan M AU - Rice, Kenner C AU - Gannon, Brenda M AU - Fantegrossi, William E AU - Gonzalez, Carmen AU - Paule, Merle G AU - Ali, Syed F AD - Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. ; Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, NIDA/NIAAA, Bethesda, MD, USA. ; Department of Pharmacology & Toxicology, UAMS, Little Rock, AR, USA. ; Facultad de Ciencias Quimicas, UASLP, SLP, Mexico. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. Electronic address: Syed.Ali@fda.hhs.gov. Y1 - 2016/08/26/ PY - 2016 DA - 2016 Aug 26 SP - 125 EP - 130 VL - 629 KW - Index Medicus KW - MDPV KW - Methamphetamine KW - Cytotoxicity KW - Blood-brain barrier KW - MDMA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811294643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Methamphetamine%2C+3%2C4-methylenedioxymethamphetamine+%28MDMA%29+and+3%2C4-methylenedioxypyrovalerone+%28MDPV%29+induce+differential+cytotoxic+effects+in+bovine+brain+microvessel+endothelial+cells.&rft.au=Rosas-Hernandez%2C+Hector%3BCuevas%2C+Elvis%3BLantz%2C+Susan+M%3BRice%2C+Kenner+C%3BGannon%2C+Brenda+M%3BFantegrossi%2C+William+E%3BGonzalez%2C+Carmen%3BPaule%2C+Merle+G%3BAli%2C+Syed+F&rft.aulast=Rosas-Hernandez&rft.aufirst=Hector&rft.date=2016-08-26&rft.volume=629&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=1872-7972&rft_id=info:doi/10.1016%2Fj.neulet.2016.06.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neulet.2016.06.029 ER - TY - JOUR T1 - sNebula, a network-based algorithm to predict binding between human leukocyte antigens and peptides. AN - 1814677310; 27558848 AB - Understanding the binding between human leukocyte antigens (HLAs) and peptides is important to understand the functioning of the immune system. Since it is time-consuming and costly to measure the binding between large numbers of HLAs and peptides, computational methods including machine learning models and network approaches have been developed to predict HLA-peptide binding. However, there are several limitations for the existing methods. We developed a network-based algorithm called sNebula to address these limitations. We curated qualitative Class I HLA-peptide binding data and demonstrated the prediction performance of sNebula on this dataset using leave-one-out cross-validation and five-fold cross-validations. This algorithm can predict not only peptides of different lengths and different types of HLAs, but also the peptides or HLAs that have no existing binding data. We believe sNebula is an effective method to predict HLA-peptide binding and thus improve our understanding of the immune system. JF - Scientific reports AU - Luo, Heng AU - Ye, Hao AU - Ng, Hui Wen AU - Sakkiah, Sugunadevi AU - Mendrick, Donna L AU - Hong, Huixiao AD - National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR 72079 USA. Y1 - 2016/08/25/ PY - 2016 DA - 2016 Aug 25 SP - 32115 VL - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814677310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=sNebula%2C+a+network-based+algorithm+to+predict+binding+between+human+leukocyte+antigens+and+peptides.&rft.au=Luo%2C+Heng%3BYe%2C+Hao%3BNg%2C+Hui+Wen%3BSakkiah%2C+Sugunadevi%3BMendrick%2C+Donna+L%3BHong%2C+Huixiao&rft.aulast=Luo&rft.aufirst=Heng&rft.date=2016-08-25&rft.volume=6&rft.issue=&rft.spage=32115&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep32115 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep32115 ER - TY - JOUR T1 - The immature rat as a potential model for chemical risks to children: Ontogeny of selected hepatic P450s. AN - 1810354085; 27387539 AB - Concern about potential susceptibilities of infants and children to chemicals has led to the consideration of immature rodents as potential test surrogates. Maturation of some hepatic microsomal cytochrome P450s (CYPs), that participate in metabolic activation of organic solvents and polycyclic aromatic hydrocarbons (PAHs), may differ significantly between humans and rodents. The present investigation was undertaken to delineate the ontogeny of selected hepatic CYPs in male and female Sprague-Dawley (S-D) rats, and to contrast them with developmental profiles in humans. Microsomes were prepared from the liver of sexed and unsexed postnatal day (PND) 1-90 rats, and total CYP450 levels, as well as CYP1A1/2, CYP2E1 and CYP2B1/2 activities and protein, were quantified. CYP1A1/2 and CYP2E1 activity and expression rose rapidly after birth, peaked from PND 21-40/50, and declined substantially to adult values by PND 90. The same ontogenic profiles were manifested when the enzyme activities were expressed per entire liver or liver normalized to body weight. CYP1A1/2 and CYP2E1 activity and protein expression were well correlated. CYP2B1/2 activity peaked abruptly on PND 21 and declined irregularly to adult values. These patterns are in contrast to human CYP1A2 and CYP2E1, which are reported to progressively increase in liver during the first few months to years of life. The three CYP protein developmental profiles were largely gender independent in rats. The immature rat does not appear to be a suitable model for assessing risks posed to infants and children by chemicals metabolically activated by CYP2E1, based on the findings of greater carbon tetrachloride hepatotoxicity in preweanlings and weanlings than in adult animals. Additional studies are required to determine whether immature S-D rats may be used as an animal model for substrates of other CYPs, as total CYP450 levels in the liver progressively rose during maturation, similarly to humans. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. JF - Chemico-biological interactions AU - McPhail, Brooks T AU - White, Catherine A AU - Cummings, Brian S AU - Muralidhara, Srinivasa AU - Wilson, Jewell T AU - Bruckner, James V AD - Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy and Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. ; ATSDR, Division of Toxicology and Human Health Sciences, Department of Health and Human Services, Atlanta, GA 30333, USA. ; Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy and Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. Electronic address: bruckner@uga.edu. Y1 - 2016/08/25/ PY - 2016 DA - 2016 Aug 25 SP - 167 EP - 177 VL - 256 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Steroid Hydroxylases KW - EC 1.14.- KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1A2 KW - Cytochrome P-450 CYP2B1 KW - steroid 16-beta-hydroxylase KW - Index Medicus KW - Carbon tetrachloride KW - Metabolic activation KW - Cytochrome P450 ontogeny KW - Hepatotoxicity KW - Children’s risk assessment KW - Animal model KW - Animals KW - Age Factors KW - Microsomes, Liver -- metabolism KW - Humans KW - Cytochrome P-450 CYP1A2 -- metabolism KW - Cytochrome P-450 CYP2B1 -- metabolism KW - Steroid Hydroxylases -- metabolism KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Child KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Risk Assessment KW - Activation, Metabolic -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Microsomes, Liver -- drug effects KW - Female KW - Male KW - Liver -- pathology KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Liver -- growth & development KW - Liver -- drug effects KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Carbon Tetrachloride -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1810354085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=The+immature+rat+as+a+potential+model+for+chemical+risks+to+children%3A+Ontogeny+of+selected+hepatic+P450s.&rft.au=McPhail%2C+Brooks+T%3BWhite%2C+Catherine+A%3BCummings%2C+Brian+S%3BMuralidhara%2C+Srinivasa%3BWilson%2C+Jewell+T%3BBruckner%2C+James+V&rft.aulast=McPhail&rft.aufirst=Brooks&rft.date=2016-08-25&rft.volume=256&rft.issue=&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2016.07.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-30 N1 - Date created - 2016-08-08 N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-01 DO - http://dx.doi.org/10.1016/j.cbi.2016.07.005 ER - TY - JOUR T1 - Estimating Inorganic Arsenic Exposure from U.S. Rice and Total Water Intakes. AN - 1859718423; 27539714 AB - Among nonoccupationally exposed U.S. residents, drinking water and diet are considered primary exposure pathways for inorganic arsenic (iAs). In drinking water, iAs is the primary form of arsenic (As), while dietary As speciation techniques are used to differentiate iAs from less toxic arsenicals in food matrices. To estimate the distribution of iAs exposure rates from drinking water intakes and rice consumption in the U.S. population and ethnic- and age-based subpopulations. The distribution of iAs in drinking water was estimated by population, weighting the iAs concentrations for each drinking water utility in the Second Six-Year Review data set. To estimate the distribution of iAs concentrations in rice ingested by U.S. consumers, 54 grain-specific, production-weighted composites of rice obtained from U.S. mills were extracted and speciated using both a quantitative dilute nitric acid extraction and speciation (DNAS) and an in vitro gastrointestinal assay to provide an upper bound and bioaccessible estimates, respectively. Daily drinking water intake and rice consumption rate distributions were developed using data from the What We Eat in America (WWEIA) study. Using these datasets, the Stochastic Human Exposure and Dose Simulation (SHEDS) model estimated mean iAs exposures from drinking water and rice were 4.2 μg/day and 1.4 μg/day, respectively, for the entire U.S. population. The Tribal, Asian, and Pacific population exhibited the highest mean daily exposure of iAs from cooked rice (2.8 μg/day); the mean exposure rate for children between ages 1 and 2 years in this population is 0.104 μg/kg body weight (BW)-day. An average consumer drinking 1.5 L of water daily that contains between 2 and 3 ng iAs/mL is exposed to approximately the same amount of iAs as a mean Tribal, Asian, and Pacific consumer is exposed to from rice. JF - Environmental health perspectives AU - Mantha, Madhavi AU - Yeary, Edward AU - Trent, John AU - Creed, Patricia A AU - Kubachka, Kevin AU - Hanley, Traci AU - Shockey, Nohora AU - Heitkemper, Douglas AU - Caruso, Joseph AU - Xue, Jianping AU - Rice, Glenn AU - Wymer, Larry AU - Creed, John T AD - Oak Ridge Institute for Science and Education Scholar, U.S. Environmental Protection Agency (U.S. EPA), National Exposure Research Laboratory (NERL), Cincinnati, Ohio, USA. ; Student Service Contractor, U.S. EPA, NERL, Cincinnati, Ohio, USA. ; U.S. EPA, NERL, Cincinnati, Ohio, USA. ; U.S. Food and Drug Administration (U.S. FDA), Forensic Chemistry Center, Cincinnati, Ohio, USA. ; University of Cincinnati, Department of Chemistry, Cincinnati, Ohio, USA. ; U.S. EPA, NERL, Research Triangle Park, North Carolina, USA. ; U.S. EPA, National Center for Environmental Assessment (NCEA), Cincinnati, Ohio, USA. Y1 - 2016/08/19/ PY - 2016 DA - 2016 Aug 19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859718423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Estimating+Inorganic+Arsenic+Exposure+from+U.S.+Rice+and+Total+Water+Intakes.&rft.au=Mantha%2C+Madhavi%3BYeary%2C+Edward%3BTrent%2C+John%3BCreed%2C+Patricia+A%3BKubachka%2C+Kevin%3BHanley%2C+Traci%3BShockey%2C+Nohora%3BHeitkemper%2C+Douglas%3BCaruso%2C+Joseph%3BXue%2C+Jianping%3BRice%2C+Glenn%3BWymer%2C+Larry%3BCreed%2C+John+T&rft.aulast=Mantha&rft.aufirst=Madhavi&rft.date=2016-08-19&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - ToxCast Chemical Landscape: Paving the Road to 21st Century Toxicology. AN - 1811843913; 27367298 AB - The U.S. Environmental Protection Agency's (EPA) ToxCast program is testing a large library of Agency-relevant chemicals using in vitro high-throughput screening (HTS) approaches to support the development of improved toxicity prediction models. Launched in 2007, Phase I of the program screened 310 chemicals, mostly pesticides, across hundreds of ToxCast assay end points. In Phase II, the ToxCast library was expanded to 1878 chemicals, culminating in the public release of screening data at the end of 2013. Subsequent expansion in Phase III has resulted in more than 3800 chemicals actively undergoing ToxCast screening, 96% of which are also being screened in the multi-Agency Tox21 project. The chemical library unpinning these efforts plays a central role in defining the scope and potential application of ToxCast HTS results. The history of the phased construction of EPA's ToxCast library is reviewed, followed by a survey of the library contents from several different vantage points. CAS Registry Numbers are used to assess ToxCast library coverage of important toxicity, regulatory, and exposure inventories. Structure-based representations of ToxCast chemicals are then used to compute physicochemical properties, substructural features, and structural alerts for toxicity and biotransformation. Cheminformatics approaches using these varied representations are applied to defining the boundaries of HTS testability, evaluating chemical diversity, and comparing the ToxCast library to potential target application inventories, such as used in EPA's Endocrine Disruption Screening Program (EDSP). Through several examples, the ToxCast chemical library is demonstrated to provide comprehensive coverage of the knowledge domains and target inventories of potential interest to EPA. Furthermore, the varied representations and approaches presented here define local chemistry domains potentially worthy of further investigation (e.g., not currently covered in the testing library or defined by toxicity "alerts") to strategically support data mining and predictive toxicology modeling moving forward. JF - Chemical research in toxicology AU - Richard, Ann M AU - Judson, Richard S AU - Houck, Keith A AU - Grulke, Christopher M AU - Volarath, Patra AU - Thillainadarajah, Inthirany AU - Yang, Chihae AU - Rathman, James AU - Martin, Matthew T AU - Wambaugh, John F AU - Knudsen, Thomas B AU - Kancherla, Jayaram AU - Mansouri, Kamel AU - Patlewicz, Grace AU - Williams, Antony J AU - Little, Stephen B AU - Crofton, Kevin M AU - Thomas, Russell S AD - National Center for Computational Toxicology, Office of Research & Development, U.S. Environmental Protection Agency , Mail Code B205-01, Research Triangle Park, Durham, North Carolina 27711, United States. ; Center for Food Safety and Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States. ; Senior Environmental Employment Program, U.S. Environmental Protection Agency , Research Triangle Park, Durham, North Carolina 27711, United States. ; Molecular Networks GmbH , Henkestraße 91, 91052 Erlangen, Germany. ; Altamira, LLC , 1455 Candlewood Drive, Columbus, Ohio 43235, United States. ; ORISE Fellow, U.S. Environmental Protection Agency, Research Triangle Park, Durham, North Carolina 27711, United States. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 1225 EP - 1251 VL - 29 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811843913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=ToxCast+Chemical+Landscape%3A+Paving+the+Road+to+21st+Century+Toxicology.&rft.au=Richard%2C+Ann+M%3BJudson%2C+Richard+S%3BHouck%2C+Keith+A%3BGrulke%2C+Christopher+M%3BVolarath%2C+Patra%3BThillainadarajah%2C+Inthirany%3BYang%2C+Chihae%3BRathman%2C+James%3BMartin%2C+Matthew+T%3BWambaugh%2C+John+F%3BKnudsen%2C+Thomas+B%3BKancherla%2C+Jayaram%3BMansouri%2C+Kamel%3BPatlewicz%2C+Grace%3BWilliams%2C+Antony+J%3BLittle%2C+Stephen+B%3BCrofton%2C+Kevin+M%3BThomas%2C+Russell+S&rft.aulast=Richard&rft.aufirst=Ann&rft.date=2016-08-15&rft.volume=29&rft.issue=8&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00135 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00135 ER - TY - JOUR T1 - Pyrrolizidine Alkaloid-Protein Adducts: Potential Non-invasive Biomarkers of Pyrrolizidine Alkaloid-Induced Liver Toxicity and Exposure. AN - 1811843109; 27388689 AB - Pyrrolizidine alkaloids (PAs) are phytochemicals present in hundreds of plant species from different families widely distributed in many geographical regions around the world. PA-containing plants are probably the most common type of poisonous plants affecting livestock, wildlife, and humans. There have been many large-scale human poisonings caused by the consumption of food contaminated with toxic PAs. PAs require metabolic activation to generate pyrrolic metabolites to exert their toxicity. In this study, we developed a novel method to quantify pyrrole-protein adducts present in the blood. This method involves the use of AgNO3 in acidic ethanol to cleave the thiol linkage of pyrrole-protein (DHP-protein) adducts, and the resulting 7,9-di-C2H5O-DHP is quantified by HPLC-ES-MS/MS multiple reaction monitoring analysis in the presence of a known quantity of isotopically labeled 7,9-di-C2D5O-DHP internal standard. Using this method, we determined that diester-type PAs administered to rats produced higher levels of DHP-protein adducts than other types of PAs. The results suggest that DHP-protein adducts can potentially serve as minimally invasive biomarkers of PA exposure. JF - Chemical research in toxicology AU - Xia, Qingsu AU - Zhao, Yuewei AU - Lin, Ge AU - Beland, Frederick A AU - Cai, Lining AU - Fu, Peter P AD - National Center for Toxicological Research , Jefferson, Arkansas 72079, United States. ; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong , Hong Kong SAR. ; Biotranex LLC , Monmouth Junction, New Jersey 08852, United States. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 1282 EP - 1292 VL - 29 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811843109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Pyrrolizidine+Alkaloid-Protein+Adducts%3A+Potential+Non-invasive+Biomarkers+of+Pyrrolizidine+Alkaloid-Induced+Liver+Toxicity+and+Exposure.&rft.au=Xia%2C+Qingsu%3BZhao%2C+Yuewei%3BLin%2C+Ge%3BBeland%2C+Frederick+A%3BCai%2C+Lining%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2016-08-15&rft.volume=29&rft.issue=8&rft.spage=1282&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00120 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00120 ER - TY - JOUR T1 - Development and application of novel histochemical tracers for localizing brain connectivity and pathology. AN - 1808386537; 27155454 AB - A NEW FLUORESCENT RETROGRADE AXONAL TRACER WITH NUMEROUS UNIQUE PROPERTIES: A new fluorescent dye, Fluoro-Gold, has been demonstrated to undergo retrograde axonal transport. Its properties include (1) intense fluorescence, (2) extensive filling of dendrites, (3) high resistance to fading, (4) no uptake by intact undamaged fibers of passage, (5) no diffusion from labeled cells, (6) consistent and pure commercial source, (7) wide latitude of survival times and (8) compatibility with all other tested neuro-histochemical techniques. © 1986. Fluoro-Jade C results in ultra high resolution and contrast labeling of degenerating neurons: The causes and effects of neuronal degeneration are of major interest to a wide variety of neuroscientists. Paralleling this growing interest is an increasing number of methods applicable to the detection of neuronal degeneration. The earliest methods employing aniline dyes were methodologically simple, but difficult to interpret due to a lack of staining specificity. In an attempt to circumvent this problem, numerous suppressed silver methods have been introduced. However, these methods are labor intensive, incompatible with most other histochemical procedures and notoriously capricious. In an attempt to develop a tracer with the methodological simplicity and reliability of conventional stains but with the specificity of an ideal suppressed silver preparation, the Fluoro-Jade dyes were developed. Fluoro-Jade C, like its predecessors, Fluoro-Jade and Fluoro-Jade B, was found to stain all degenerating neurons, regardless of specific insult or mechanism of cell death. Therefore, the patterns of neuronal degeneration seen following exposure to either the glutamate agonist, kainic acid, or the inhibitor of mitochondrial respiration, 3-NPA, were the same for all of the Fluoro-Jade dyes. However, there was a qualitative difference in the staining characteristics of the three fluorochromes. Specifically, Fluoro-Jade C exhibited the greatest signal to background ratio, as well as the highest resolution. This translates to a stain of maximal contrast and affinity for degenerating neurons. This makes it ideal for localizing not only degenerating nerve cell bodies, but also distal dendrites, axons and terminals. The dye is highly resistant to fading and is compatible with virtually all histological processing and staining protocols. Triple labeling was accomplished by staining degenerating neurons with Fluoro-Jade C, cell nuclei with DAPI and activated astrocytes with GFAP immunofluoresence. © 2005. The development of novel tracers and associated histochemical methods has always been need driven. One such need was the development of tracers that could be administered to discrete brain regions in vivo to subsequently reveal neuronal connectivity via axonal transport of the tracer. One such compound is Fluoro-Gold (F-G), which can be used to demonstrate retrograde axonal transport. Advantages of this fluorescent tracer include brightness, sensitivity, contrast, stability, permanence and compatibility with multiple labeling studies. It may be applied to resolve either the afferent or efferent connections of brain regions of interest. Another need addressed was for a simple and definitive way to localize degenerating neurons in brain tissue sections. This led to the development of Fluoro-Jade B (FJ-B) and Fluoro-Jade C (FJ-C). Advantages of these fluorescent histochemical tracers include high specificity, resolution, contrast, stability and suitability for use in multiple labeling studies. These methods can be applied to detect both apoptotic and necrotic neuronal degeneration following a variety of insults including physical trauma, neurodegenerative disease and a wide variety of neurotoxicants. This article is part of a Special Issue entitled SI:50th Anniversary Issue. Copyright © 2016. Published by Elsevier B.V. JF - Brain research AU - Schmued, Larry C AD - US Food and Drug Administration (FDA), National Center for Toxicological Research (NCTR), Division of Neurotoxicology, 3900 NCTR Rd, Jefferson, AR 72079United States. Electronic address: larry.schmued@fda.hhs.gov. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 31 EP - 35 VL - 1645 KW - Index Medicus KW - Neurotoxicants KW - Axonal transport KW - Fluoro-Jade C KW - Fluoro-Gold KW - Neuronal degeneration KW - Brain pathology KW - Neuronal connectivity KW - Axonal tract tracing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808386537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Development+and+application+of+novel+histochemical+tracers+for+localizing+brain+connectivity+and+pathology.&rft.au=Schmued%2C+Larry+C&rft.aulast=Schmued&rft.aufirst=Larry&rft.date=2016-08-15&rft.volume=1645&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=1872-6240&rft_id=info:doi/10.1016%2Fj.brainres.2016.03.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.brainres.2016.03.053 ER - TY - JOUR T1 - Arsenic in private well water part 3 of 3: Socioeconomic vulnerability to exposure in Maine and New Jersey. AN - 1793903070; 27118035 AB - Arsenic is a naturally occurring toxic element often concentrated in groundwater at levels unsafe for human consumption. Private well water in the United States is mostly unregulated by federal and state drinking water standards. It is the responsibility of the over 13 million U.S. households regularly depending on private wells for their water to ensure it is safe for drinking. There is a consistent graded association with health outcomes at all levels of socioeconomic status (SES) in the U.S. Differential exposure to environmental risk may be contributing to this persistent SES-health gradient. Environmental justice advocates cite overwhelming evidence that income and other SES measures are consistently inversely correlated with exposure to suboptimal environmental conditions including pollutants, toxins, and their impacts. Here we use private well household surveys from two states to investigate the association between SES and risks for arsenic exposure, examining the potentially cumulative effects of residential location, testing and treatment behavior, and psychological factors influencing behavior. We find that the distribution of natural arsenic hazard in the environment is socioeconomically random. There is no evidence that higher SES households are avoiding areas with arsenic or that lower SES groups are disproportionately residing in areas with arsenic. Instead, disparities in exposure arise from differing rates of protective action, primarily testing well water for arsenic, and secondly treating or avoiding contaminated water. We observe these SES disparities in behavior as well as in the psychological factors that are most favorable to these behaviors. Assessment of risk should not be limited to the spatial occurrence of arsenic alone. It is important that social vulnerability factors are incorporated into risk modeling and identifying priority areas for intervention, which should include strategies that specifically target socioeconomically vulnerable groups as well as all the conditions which cause these disparities in testing and treatment behavior. Copyright © 2016 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Flanagan, Sara V AU - Spayd, Steven E AU - Procopio, Nicholas A AU - Marvinney, Robert G AU - Smith, Andrew E AU - Chillrud, Steven N AU - Braman, Stuart AU - Zheng, Yan AD - Columbia University, Lamont-Doherty Earth Observatory, 61 Route 9W, Palisades, NY 10964, USA; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th Street, New York, NY 10027, USA; New Jersey Department of Environmental Protection, P.O. Box 420, Trenton, NJ 08625-0420, USA. Electronic address: Flanagan@ldeo.columbia.edu. ; New Jersey Department of Environmental Protection, P.O. Box 420, Trenton, NJ 08625-0420, USA. Electronic address: Steve.Spayd@dep.nj.gov. ; New Jersey Department of Environmental Protection, P.O. Box 420, Trenton, NJ 08625-0420, USA. Electronic address: Nick.Procopio@dep.nj.gov. ; Maine Geological Survey, 93 State House Station, Augusta, ME 04333, USA. Electronic address: Robert.G.Marvinney@maine.gov. ; Maine Department of Health and Human Services, Maine Center for Disease Control and Prevention, 286 Water Street, Augusta, ME 04333, USA. Electronic address: Andy.E.Smith@maine.gov. ; Columbia University, Lamont-Doherty Earth Observatory, 61 Route 9W, Palisades, NY 10964, USA. Electronic address: Chilli@ldeo.columbia.edu. ; Columbia University, Lamont-Doherty Earth Observatory, 61 Route 9W, Palisades, NY 10964, USA. Electronic address: SBraman@ldeo.columbia.edu. ; Columbia University, Lamont-Doherty Earth Observatory, 61 Route 9W, Palisades, NY 10964, USA; Graduate School of Public Health and Health Policy, City University of New York, 55 W 125th Street, New York, NY 10027, USA; Queens College, City University of New York, 65-30 Kissena Blvd, Flushing, NY 11367, USA. Electronic address: YZheng@ldeo.columbia.edu. Y1 - 2016/08/15/ PY - 2016 DA - 2016 Aug 15 SP - 1019 EP - 1030 VL - 562 KW - Index Medicus KW - Arsenic KW - Private well KW - Environmental justice KW - Disparities KW - Socioeconomic status KW - Drinking water UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793903070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Arsenic+in+private+well+water+part+3+of+3%3A+Socioeconomic+vulnerability+to+exposure+in+Maine+and+New+Jersey.&rft.au=Flanagan%2C+Sara+V%3BSpayd%2C+Steven+E%3BProcopio%2C+Nicholas+A%3BMarvinney%2C+Robert+G%3BSmith%2C+Andrew+E%3BChillrud%2C+Steven+N%3BBraman%2C+Stuart%3BZheng%2C+Yan&rft.aulast=Flanagan&rft.aufirst=Sara&rft.date=2016-08-15&rft.volume=562&rft.issue=&rft.spage=1019&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2016.03.217 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2016.03.217 ER - TY - JOUR T1 - Editorial: Promising approaches to identify DILI drugs. AN - 1803115162; 27393768 JF - Chemico-biological interactions AU - Li, Albert P AU - Zhang, Jie AD - In Vitro ADMET Laboratories Inc., Columbia, MD, USA. Electronic address: liabert@invitroadmet.com. ; The National Center for Toxicological Research U. S. Food and Drug Administration, Jefferson, AR, USA. Electronic address: Jie.Zhang@fda.hhs.gov. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 1 EP - 2 VL - 255 KW - Pharmaceutical Preparations KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Pharmaceutical Preparations -- metabolism KW - Humans KW - Toxicity Tests -- methods KW - Cytochrome P-450 Enzyme System -- metabolism KW - Chemical and Drug Induced Liver Injury -- etiology KW - Drug Evaluation, Preclinical -- methods KW - Chemical and Drug Induced Liver Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803115162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Editorial%3A+Promising+approaches+to+identify+DILI+drugs.&rft.au=Li%2C+Albert+P%3BZhang%2C+Jie&rft.aulast=Li&rft.aufirst=Albert&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2016.06.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2016.06.021 ER - TY - JOUR T1 - Inhibition of bile salt transport by drugs associated with liver injury in primary hepatocytes from human, monkey, dog, rat, and mouse. AN - 1803112065; 27000539 AB - Interference of bile salt transport is one of the underlying mechanisms for drug-induced liver injury (DILI). We developed a novel bile salt transport activity assay involving in situ biosynthesis of bile salts from their precursors in primary human, monkey, dog, rat, and mouse hepatocytes in suspension as well as LC-MS/MS determination of extracellular bile salts transported out of hepatocytes. Glycine- and taurine-conjugated bile acids were rapidly formed in hepatocytes and effectively transported into the extracellular medium. The bile salt formation and transport activities were time‒ and bile-acid-concentration‒dependent in primary human hepatocytes. The transport activity was inhibited by the bile salt export pump (BSEP) inhibitors ketoconazole, saquinavir, cyclosporine, and troglitazone. The assay was used to test 86 drugs for their potential to inhibit bile salt transport activity in human hepatocytes, which included 35 drugs associated with severe DILI (sDILI) and 51 with non-severe DILI (non-sDILI). Approximately 60% of the sDILI drugs showed potent inhibition (with IC50 values <50 μM), but only about 20% of the non-sDILI drugs showed this strength of inhibition in primary human hepatocytes and these drugs are associated only with cholestatic and mixed hepatocellular cholestatic (mixed) injuries. The sDILI drugs, which did not show substantial inhibition of bile salt transport activity, are likely to be associated with immune-mediated liver injury. Twenty-four drugs were also tested in monkey, dog, rat and mouse hepatocytes. Species differences in potency were observed with mouse being less sensitive than other species to inhibition of bile salt transport. In summary, a novel assay has been developed using hepatocytes in suspension from human and animal species that can be used to assess the potential for drugs and/or drug-derived metabolites to inhibit bile salt transport and/or formation activity. Drugs causing sDILI, except those by immune-mediated mechanism, are highly associated with potent inhibition of bile salt transport. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Zhang, Jie AU - He, Kan AU - Cai, Lining AU - Chen, Yu-Chuan AU - Yang, Yifan AU - Shi, Qin AU - Woolf, Thomas F AU - Ge, Weigong AU - Guo, Lei AU - Borlak, Jürgen AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: jie.zhang@fda.hhs.gov. ; Biotranex LLC, Monmouth Junction, NJ 08852, USA. Electronic address: khe@biotranex.com. ; Biotranex LLC, Monmouth Junction, NJ 08852, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 45 EP - 54 VL - 255 KW - ABCB11 protein, human KW - 0 KW - Bile Acids and Salts KW - Pharmaceutical Preparations KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Species difference KW - DILI KW - Hepatocytes KW - Bile salts KW - ABCB11 KW - Drug-induced liver injury KW - Bile salt export pump KW - BSEP KW - Young Adult KW - Animals KW - Humans KW - Tandem Mass Spectrometry -- methods KW - Aged KW - Mice KW - Haplorhini KW - Rats KW - Pharmaceutical Preparations -- metabolism KW - Cells, Cultured KW - Adenosine Triphosphate -- metabolism KW - Adult KW - Dogs KW - Cell Culture Techniques -- methods KW - Middle Aged KW - Adolescent KW - Drug Evaluation, Preclinical -- methods KW - Male KW - Female KW - Biological Transport, Active -- drug effects KW - Hepatocytes -- drug effects KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - ATP-Binding Cassette Transporters -- metabolism KW - Hepatocytes -- pathology KW - ATP-Binding Cassette Transporters -- antagonists & inhibitors KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Bile Acids and Salts -- metabolism KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803112065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Inhibition+of+bile+salt+transport+by+drugs+associated+with+liver+injury+in+primary+hepatocytes+from+human%2C+monkey%2C+dog%2C+rat%2C+and+mouse.&rft.au=Zhang%2C+Jie%3BHe%2C+Kan%3BCai%2C+Lining%3BChen%2C+Yu-Chuan%3BYang%2C+Yifan%3BShi%2C+Qin%3BWoolf%2C+Thomas+F%3BGe%2C+Weigong%3BGuo%2C+Lei%3BBorlak%2C+J%C3%BCrgen%3BTong%2C+Weida&rft.aulast=Zhang&rft.aufirst=Jie&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2016.03.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2016.03.019 ER - TY - JOUR T1 - The cytochrome P450 inhibitor SKF-525A disrupts autophagy in primary rat hepatocytes. AN - 1803111825; 26964495 AB - The cytochrome P450 (CYP) inhibitor SKF-525A is commonly used to study drug metabolism and toxicity, particularly hepatotoxicity. By using Western blot and immunofluorescence staining, we unexpectedly found that SKF-525A at 2-20 μM caused remarkable accumulation of microtubule-associated protein light chain 3 II (LC3-II) in primary rat hepatocytes at 1, 4 and 24 h, indicating that autophagy was disrupted. SKF-525A showed no effects on chloroquine induced LC3-II accumulation, suggesting that autophagic flux was blocked, which is further supported by the increased level of the p62 protein after SKF-525A treatment. SKF-525A did not affect proteasome activities or gene expression of LC3-II or p62. Immunofluorescence of green fluorescent protein fused lysosomal-associated membrane protein 1 (LAMP1, a specific protein marker for lysosomes) and LC3-II showed that co-localization of these two proteins was partially abolished by SKF-525A, indicating that autophagosome-lysosome fusion was blocked. The other five CYP inhibitors, metyrapone, 1-aminobenzotriazole, alpha-naphthoflavone, ticlopidine, and ketoconazole, showed no effects in parallel experiments. These findings provide novel insights into the mechanisms by which various CYP inhibitors differentially affect a same drug's toxicity in hepatocytes. The data also indicate that SKF-525A is not an ideal chemical inhibitor for probing the relation between CYP mediated metabolism and toxicity in primary hepatocytes. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Luo, Yong AU - Yang, Xi AU - Shi, Qiang AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: qiang.shi@fda.hhs.gov. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 55 EP - 62 VL - 255 KW - Cytochrome P-450 Enzyme Inhibitors KW - 0 KW - LC3 protein, rat KW - Microtubule-Associated Proteins KW - Proadifen KW - A510CA4CBT KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Hepatocyte KW - Autophagy KW - Cytochrome P450 KW - Hepatotoxicity KW - SKF-525A KW - Animals KW - Microtubule-Associated Proteins -- metabolism KW - Lysosomes -- pathology KW - Autophagosomes -- drug effects KW - Lysosomes -- metabolism KW - Rats KW - Rats, Sprague-Dawley KW - Proteasome Endopeptidase Complex -- metabolism KW - Cells, Cultured KW - Membrane Fusion -- drug effects KW - Autophagosomes -- metabolism KW - Lysosomes -- drug effects KW - Autophagosomes -- pathology KW - Male KW - Autophagy -- drug effects KW - Hepatocytes -- drug effects KW - Cytochrome P-450 Enzyme Inhibitors -- toxicity KW - Proadifen -- toxicity KW - Hepatocytes -- pathology KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803111825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=The+cytochrome+P450+inhibitor+SKF-525A+disrupts+autophagy+in+primary+rat+hepatocytes.&rft.au=Luo%2C+Yong%3BYang%2C+Xi%3BShi%2C+Qiang&rft.aulast=Luo&rft.aufirst=Yong&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2016.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2016.03.007 ER - TY - JOUR T1 - Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity. AN - 1803111396; 26477383 AB - The generation of reactive metabolites from therapeutic agents is one of the major mechanisms of drug-induced liver injury (DILI). In order to evaluate metabolism-related toxicity and improve drug efficacy and safety, we generated a battery of HepG2-derived cell lines that express 14 cytochrome P450s (CYPs) (1A1, 1A2, 1B1, 2A6, 2B6, 2C8, 2C9, 2C18, 2C19, 2D6, 2E1, 3A4, 3A5 and 3A7) individually using a lentiviral expression system. The expression/production of a specific CYP in each cell line was confirmed by an increased abundance of the CYP at both mRNA and protein levels. Moreover, the enzymatic activities of representative CYPs in the corresponding cell lines were also measured. Using our CYP-expressed HepG2 cells, the toxicity of three drugs that could induce DILI (amiodarone, chlorpromazine and primaquine) was assessed, and all of them showed altered (increased or decreased) toxicity compared to the toxicity in drug-treated wild-type HepG2 cells. CYP-mediated drug toxicity examined in our cell system is consistent with previous reports, demonstrating the potential of these cells for assessing metabolism-related drug toxicity. This cell system provides a practical in vitro approach for drug metabolism screening and for early detection of drug toxicity. It is also a surrogate enzyme source for the enzymatic characterization of a particular CYP that contributes to drug-induced liver toxicity. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Xuan, Jiekun AU - Chen, Si AU - Ning, Baitang AU - Tolleson, William H AU - Guo, Lei AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of System Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Lei.Guo@fda.hhs.gov. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 63 EP - 73 VL - 255 KW - Antimalarials KW - 0 KW - Antipsychotic Agents KW - Cytochrome P-450 Enzyme Inhibitors KW - Protein Isoforms KW - RNA, Messenger KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Primaquine KW - MVR3634GX1 KW - Amiodarone KW - N3RQ532IUT KW - Chlorpromazine KW - U42B7VYA4P KW - Index Medicus KW - Drug metabolizing enzyme KW - HepG2 KW - Cytochrome P450s KW - Drug-induced liver toxicity KW - Antimalarials -- toxicity KW - Primaquine -- toxicity KW - Humans KW - Protein Isoforms -- metabolism KW - Gene Expression KW - RNA, Messenger -- genetics KW - Hep G2 Cells KW - Cytochrome P-450 Enzyme Inhibitors -- toxicity KW - Drug Evaluation, Preclinical -- methods KW - Protein Isoforms -- genetics KW - Chlorpromazine -- toxicity KW - Cell Line KW - Antipsychotic Agents -- toxicity KW - Liver -- pathology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Liver -- drug effects KW - Cytochrome P-450 Enzyme System -- genetics KW - Chemical and Drug Induced Liver Injury -- genetics KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Amiodarone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803111396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Development+of+HepG2-derived+cells+expressing+cytochrome+P450s+for+assessing+metabolism-associated+drug-induced+liver+toxicity.&rft.au=Xuan%2C+Jiekun%3BChen%2C+Si%3BNing%2C+Baitang%3BTolleson%2C+William+H%3BGuo%2C+Lei&rft.aulast=Xuan&rft.aufirst=Jiekun&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2015.10.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2015.10.009 ER - TY - JOUR T1 - Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles. AN - 1803111297; 26581450 AB - We report here the results of a collaborative research program to develop a robust and reliable in vitro system to allow an accurate definition of the drug-induced liver injury (DILI) potential of new drug entities during drug development. The in vitro hepatotoxic potential of 152 drugs with known DILI profiles were evaluated in primary cultured human hepatocytes with four mechanistically-relevant endpoints: cellular ATP depletion, reactive oxygen species (ROS), glutathione (GSH) depletion, and caspase activation for apoptosis. The drugs, 80 in the testing set and 72 in the validation set, were classified based on serious clinical/regulatory outcomes as defined by reported acute liver failure, black-box warning, and/or withdrawal. The drugs were further sub-categorized for dominant types of liver injury. Logistic regression models were performed to calculate the area under the receiver operating characteristics curve (AUROC) and to evaluate the prediction potential of the selected endpoints for serious clinical/regulatory outcomes. The ROS/ATP ratio was found to yield an excellent AUROC in both the testing (0.8989, P < 0.0001) and validation set (0.8545, P < 0.0001), and was found to distinguish drugs associated with severe from non-severe DILI cases (p < 0.0001). The results suggest that evaluation of drugs in primary human hepatocytes using the ROS/ATP ratio endpoint may aid the definition of their potential to cause severe DILI. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Chemico-biological interactions AU - Zhang, Jie AU - Doshi, Utkarsh AU - Suzuki, Ayako AU - Chang, Ching-Wei AU - Borlak, Jürgen AU - Li, Albert P AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, NCTR/FDA, Jefferson, AR, USA. ; In Vitro ADMET Laboratories LLC, Columbia, MD, USA. ; Division of Gastroenterology, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA. ; Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. ; In Vitro ADMET Laboratories LLC, Columbia, MD, USA. Electronic address: lialbert@invitroadmet.com. ; Division of Bioinformatics and Biostatistics, NCTR/FDA, Jefferson, AR, USA. Electronic address: Weida.Tong@fda.hhs.gov. Y1 - 2016/08/05/ PY - 2016 DA - 2016 Aug 05 SP - 3 EP - 11 VL - 255 KW - Pharmaceutical Preparations KW - 0 KW - Reactive Oxygen Species KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Acute liver failure KW - Oxidative stress KW - In vitro toxicity testing KW - Drug induced liver injury KW - Drug development KW - Human hepatocytes KW - Young Adult KW - Liver -- pathology KW - Liver -- drug effects KW - Cells, Cultured KW - Humans KW - Glutathione -- metabolism KW - Liver -- metabolism KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Reactive Oxygen Species -- metabolism KW - Pharmaceutical Preparations -- metabolism KW - Hepatocytes -- drug effects KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Adenosine Triphosphate -- metabolism KW - Hepatocytes -- pathology KW - Drug Evaluation, Preclinical -- methods KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803111297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Evaluation+of+multiple+mechanism-based+toxicity+endpoints+in+primary+cultured+human+hepatocytes+for+the+identification+of+drugs+with+clinical+hepatotoxicity%3A+Results+from+152+marketed+drugs+with+known+liver+injury+profiles.&rft.au=Zhang%2C+Jie%3BDoshi%2C+Utkarsh%3BSuzuki%2C+Ayako%3BChang%2C+Ching-Wei%3BBorlak%2C+J%C3%BCrgen%3BLi%2C+Albert+P%3BTong%2C+Weida&rft.aulast=Zhang&rft.aufirst=Jie&rft.date=2016-08-05&rft.volume=255&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2015.11.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-25 N1 - Date created - 2016-07-10 N1 - Date revised - 2017-01-27 N1 - Last updated - 2017-01-28 DO - http://dx.doi.org/10.1016/j.cbi.2015.11.008 ER - TY - JOUR T1 - Integrative Functional Genomics Implicates EPB41 Dysregulation in Hepatocellular Carcinoma Risk. AN - 1809603683; 27453575 AB - Genome-wide association studies (GWASs) have provided many insights into cancer genetics. However, the molecular mechanisms of many susceptibility SNPs defined by GWASs in cancer heritability and in promoting cancer risk remain elusive. New research strategies, including functional evaluations, are warranted to systematically explore truly causal genetic variants. In this study, we developed an integrative functional genomics methodology to identify cancer susceptibility SNPs in transcription factor-binding sites across the whole genome. Employing integration of functional genomic data from c-Myc cistromics, 1000 Genomes, and the TRANSFAC matrix, we successfully annotated 12 SNPs present in the c-Myc cistrome with properties consistent with modulating c-Myc binding affinity in hepatocellular carcinoma (HCC). After genotyping these 12 SNPs in 1,806 HBV-related HCC case subjects and 1,708 control subjects, we identified a HCC susceptibility SNP, rs157224G>T, in Chinese populations (T allele: odds ratio = 1.64, 95% confidence interval = 1.32-2.02; p = 5.2 × 10(-6)). This polymorphism leads to HCC predisposition through modifying c-Myc-mediated transcriptional regulation of EPB41, with the risk rs157224T allele showing significantly decreased gene expression. Based on cell proliferation, wound healing, and transwell assays as well as the mouse xenograft model, we identify EPB41 as a HCC susceptibility gene in vitro and in vivo. Consistent with this notion, we note that EPB41 expression is significantly decreased in HCC tissue specimens, especially in portal vein metastasis or intrahepatic metastasis, compared to normal tissues. Our results highlight the involvement of regulatory genetic variants in HCC and provide pathogenic insights of this malignancy via a genome-wide approach. Copyright © 2016 American Society of Human Genetics. All rights reserved. JF - American journal of human genetics AU - Yang, Xinyu AU - Yu, Dianke AU - Ren, Yanli AU - Wei, Jinyu AU - Pan, Wenting AU - Zhou, Changchun AU - Zhou, Liqing AU - Liu, Yu AU - Yang, Ming AD - Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China. ; Clinical Laboratory, Shandong Cancer Hospital, Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China. ; Department of Radiation Oncology, Huaian No. 2 Hospital, Huaian, Jiangsu Province 223002, China. ; Department of Etiology and Carcinogenesis, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. ; Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong Province 250117, China. Electronic address: aaryoung@yeah.net. Y1 - 2016/08/04/ PY - 2016 DA - 2016 Aug 04 SP - 275 EP - 286 VL - 99 IS - 2 KW - Index Medicus KW - EPB41 KW - susceptibility KW - HBV KW - genetic variant KW - c-Myc KW - HCC UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809603683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+human+genetics&rft.atitle=Integrative+Functional+Genomics+Implicates+EPB41+Dysregulation+in+Hepatocellular+Carcinoma+Risk.&rft.au=Yang%2C+Xinyu%3BYu%2C+Dianke%3BRen%2C+Yanli%3BWei%2C+Jinyu%3BPan%2C+Wenting%3BZhou%2C+Changchun%3BZhou%2C+Liqing%3BLiu%2C+Yu%3BYang%2C+Ming&rft.aulast=Yang&rft.aufirst=Xinyu&rft.date=2016-08-04&rft.volume=99&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=American+journal+of+human+genetics&rft.issn=1537-6605&rft_id=info:doi/10.1016%2Fj.ajhg.2016.05.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-04 N1 - Date revised - 2017-02-06 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1016/j.ajhg.2016.05.029 ER - TY - JOUR T1 - Survey of undeclared egg allergen levels in the most frequently recalled food types (including products bearing precautionary labelling) AN - 1827906312; PQ0003693530 AB - Since the number of recalls involving undeclared allergens is commonly associated with bakery and snack foods, we aimed to determine the frequency of egg allergens in a large number of these products using two commercial enzyme-linked immunosorbent assay (ELISA) methods. Samples were chosen that either had no egg identified on the product label or which had an egg precautionary statement. Among all samples, egg protein was detected in 5% of products using a Morinaga (MO) kit and 1% of products using a R-Biopharm (RB) kit. For bakery samples, egg protein was detected in 6% of 363 samples with no precautionary labelling (6% by MO and 1% by RB kit) and 12% of 80 samples which had precautionary labelling. For snack samples, egg protein was detected in 2% of 371 samples with no precautionary labelling (2% by MO and < 1% by RB kit) and 5% of 21 samples which had precautionary labelling. The disagreement rates between two methods were 5.2% for bakery products and 2.6% for snack products. The sample repeatability was at an acceptable level for bakery (< 12.5%) and snack foods (< 7.5%) for each method. The relative standard deviation between test kits was high (103.1%) for bakery foods. Four bakery products without precautionary labelling had a higher level of egg protein per serving compared with the eliciting dose (ED sub(10) of 3.7 mg protein) for egg allergic patients. These results highlight the fact that detection methodology plays a vital role for accurate labelling control and mitigation of risk for egg allergic consumers. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Khuda, Sefat E AU - Sharma, Girdhari M AU - Gaines, Dennis AU - Do, Andrew B AU - Pereira, Marion AU - Chang, Michael AU - Ferguson, Martine AU - Williams, Kristina M AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration (USFDA), 8301 Muirkirk Road, Laurel, MD 20708, USA Y1 - 2016/08/02/ PY - 2016 DA - 2016 Aug 02 SP - 1265 EP - 1273 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 8 SN - 1944-0049, 1944-0049 KW - Immunology Abstracts; Environment Abstracts KW - Risk assessment KW - Mitigation KW - Food additives KW - Allergens KW - Proteins KW - Immunoassays KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827906312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Survey+of+undeclared+egg+allergen+levels+in+the+most+frequently+recalled+food+types+%28including+products+bearing+precautionary+labelling%29&rft.au=Khuda%2C+Sefat+E%3BSharma%2C+Girdhari+M%3BGaines%2C+Dennis%3BDo%2C+Andrew+B%3BPereira%2C+Marion%3BChang%2C+Michael%3BFerguson%2C+Martine%3BWilliams%2C+Kristina+M&rft.aulast=Khuda&rft.aufirst=Sefat&rft.date=2016-08-02&rft.volume=33&rft.issue=8&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1198051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Mitigation; Allergens; Proteins; Immunoassays DO - http://dx.doi.org/10.1080/19440049.2016.1198051 ER - TY - JOUR T1 - Survey of undeclared soy allergen levels in the most frequently recalled food categories with or without precautionary labelling AN - 1827902856; PQ0003693531 AB - A comprehensive study was designed to determine the frequency and levels of soy allergen in packaged bakery and snack food products. A representative sample of products with no soy allergen disclosed on the label was analysed using two widely used enzyme-linked immunosorbent assay (ELISA) methods. Samples were chosen that either had no soy identified on the product label or which had a soy precautionary statement. Among 558 bakery and snack products, soy protein was detected in 17% of the products using the Neogen (NE) kit and 11% of the products using the Elisa Systems (ES) kit. The disagreement rates between kits were 8.8% for bakery products and 3.3% for snack products. Overall soy protein was detected at higher frequency in bakery products than in snack foods. Among 284 bakery samples, soy protein was detected in 25% of the samples with no precautionary statement and 19% of the samples which had a precautionary statement. Among 274 snack samples, soy protein was detected in 11% of the samples with no precautionary statement and 9% of the samples which had a precautionary statement. The sample repeatability was at an acceptable level ( 5 ppm) had a higher level of soy protein per serving compared with the eliciting dose sub(10) (ED sub(10)) of 10.6 mg for soy allergic patients. But the level of soy protein per serving may be clinically relevant to a subpopulation of soy allergic patients if a more stringent eliciting dose is applied. These findings emphasise that suitable detection methodologies and references doses are crucial for labelling accuracy and the safety of soy allergic consumers. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Khuda, Sefat E AU - Sharma, Girdhari M AU - Gaines, Dennis AU - Do, Andrew B AU - Pereira, Marion AU - Chang, Michael AU - Ferguson, Martine AU - Williams, Kristina M AD - Center for Food Safety and Applied Nutrition, United States Food and Drug Administration (USFDA), Laurel, MD, USA Y1 - 2016/08/02/ PY - 2016 DA - 2016 Aug 02 SP - 1274 EP - 1282 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 8 SN - 1944-0049, 1944-0049 KW - Immunology Abstracts; Environment Abstracts KW - Risk assessment KW - Food additives KW - Allergens KW - Subpopulations KW - Safety KW - Proteins KW - Immunoassays KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827902856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Survey+of+undeclared+soy+allergen+levels+in+the+most+frequently+recalled+food+categories+with+or+without+precautionary+labelling&rft.au=Khuda%2C+Sefat+E%3BSharma%2C+Girdhari+M%3BGaines%2C+Dennis%3BDo%2C+Andrew+B%3BPereira%2C+Marion%3BChang%2C+Michael%3BFerguson%2C+Martine%3BWilliams%2C+Kristina+M&rft.aulast=Khuda&rft.aufirst=Sefat&rft.date=2016-08-02&rft.volume=33&rft.issue=8&rft.spage=1274&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1207809 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Subpopulations; Allergens; Safety; Proteins; Immunoassays DO - http://dx.doi.org/10.1080/19440049.2016.1207809 ER - TY - JOUR T1 - The development and testing of a prototype mini-baghouse to control the release of respirable crystalline silica from sand movers AN - 1808664081; PQ0003402130 AB - Inhalation of respirable crystalline silica (RCS) is a significant risk to worker health during well completions operations (which include hydraulic fracturing) at conventional and unconventional oil and gas extraction sites. RCS is generated by pneumatic transfer of quartz-containing sand during hydraulic fracturing operations. National Institute for Occupational Safety and Health (NIOSH) researchers identified concentrations of RCS at hydraulic fracturing sites that exceed 10 times the Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (PEL) and up to 50 times the NIOSH Recommended Exposure Limit (REL). NIOSH research identified at least seven point sources of dust release at contemporary oil and gas extraction sites where RCS aerosols were generated. NIOSH researchers recommend the use of engineering controls wherever they can be implemented to limit the RCS released. A control developed to address one of the largest sources of RCS aerosol generation is the NIOSH mini-baghouse assembly, mounted on the thief hatches on top of the sand mover. This article details the results of a trial of the NIOSH mini-baghouse at a sand mine in Arkansas from November 18-21, 2013. During the trial, area air samples were collected at 12 locations on and around a sand mover with and without the mini-baghouse control installed. Analytical results for respirable dust and RCS indicate the use of the mini-baghouse effectively reduced both respirable dust and RCS downwind of the thief hatches. Reduction of airborne respirable dust ranged from 85-98%; reductions in airborne RCS ranged from 79-99%. A bulk sample of dust collected by the baghouse assembly showed the likely presence of freshly fractured quartz, a particularly hazardous form of RCS. Planned future design enhancements will increase the performance and durability of the mini-baghouse, including an improved bag clamp mechanism and upgraded filter fabric with a modified air-to-cloth ratio. Future trials are planned to determine additional respirable dust and RCS concentration reductions achieved through these design changes. JF - Journal of Occupational and Environmental Hygiene AU - Alexander, Barbara M AU - Esswein, Eric J AU - Gressel, Michael G AU - Kratzer, Jerry L AU - Feng, HAmy AU - King, Bradley AU - Miller, Arthur L AU - Cauda, Emanuele AD - National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio Y1 - 2016/08/02/ PY - 2016 DA - 2016 Aug 02 SP - 628 EP - 638 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 8 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Hydraulics KW - Prototypes KW - Occupational safety KW - Dust KW - Oil KW - Workers KW - Sand KW - Quartz KW - Air sampling KW - Baghouses KW - Pollution control equipment KW - Wind KW - Occupational exposure KW - Environmental hygiene KW - Aerosols KW - Oil and gas industry KW - Fractures KW - Mines KW - Filters KW - Fabrics KW - Silica KW - USA, Arkansas KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808664081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=The+development+and+testing+of+a+prototype+mini-baghouse+to+control+the+release+of+respirable+crystalline+silica+from+sand+movers&rft.au=Alexander%2C+Barbara+M%3BEsswein%2C+Eric+J%3BGressel%2C+Michael+G%3BKratzer%2C+Jerry+L%3BFeng%2C+HAmy%3BKing%2C+Bradley%3BMiller%2C+Arthur+L%3BCauda%2C+Emanuele&rft.aulast=Alexander&rft.aufirst=Barbara&rft.date=2016-08-02&rft.volume=13&rft.issue=8&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1168239 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Hydraulics; Aerosols; Fractures; Mines; Dust; Fabrics; Oil; Filters; Workers; Silica; Sand; Quartz; Occupational exposure; Environmental hygiene; Prototypes; Oil and gas industry; Occupational safety; Air sampling; Baghouses; Pollution control equipment; Wind; USA, Arkansas DO - http://dx.doi.org/10.1080/15459624.2016.1168239 ER - TY - JOUR T1 - Comparison of estimated core body temperature measured with the BioHarness and rectal temperature under several heat stress conditions AN - 1808660634; PQ0003402128 AB - Monitoring and measuring core body temperature is important to prevent or minimize physiological strain and cognitive dysfunction for workers such as first responders (e.g., firefighters) and military personnel. The purpose of this study is to compare estimated core body temperature (Tco-est), determined by heart rate (HR) data from a wearable chest strap physiology monitor, to standard rectal thermometry (Tre) under different conditions. Tco-est and Tre measurements were obtained in thermoneutral and heat stress conditions (high temperature and relative humidity) during four different experiments including treadmill exercise, cycling exercise, passive heat stress, and treadmill exercise while wearing personal protective equipment (PPE). Overall, the mean Tco-est did not differ significantly from Tre across the four conditions. During exercise at low-moderate work rates under heat stress conditions, Tco-est was consistently higher than Tre at all-time points. Tco-est underestimated temperature compared to Tre at rest in heat stress conditions and at a low work rate under heat stress while wearing PPE. The mean differences between the two measurements ranged from -0.1 plus or minus 0.4 to 0.3 plus or minus 0.4 degree C and Tco-est correlated well with HR (r = 0.795 - 0.849) and mean body temperature (r = 0.637 - 0.861). These results indicate that, the comparison of Tco-est to Tre may result in over- or underestimation which could possibly lead to heat-related illness during monitoring in certain conditions. Modifications to the current algorithm should be considered to address such issues. JF - Journal of Occupational and Environmental Hygiene AU - Seo, Yongsuk AU - DiLeo, Travis AU - Powell, Jeffrey B AU - Kim, Jung-Hyun AU - Roberge, Raymond J AU - Coca, Aitor AD - National Personal Protective Technology Laboratory, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Pittsburgh, Pennsylvania Y1 - 2016/08/02/ PY - 2016 DA - 2016 Aug 02 SP - 612 EP - 620 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 8 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - High temperature KW - Physiology KW - Heart rate KW - Firefighter services KW - Heat tolerance KW - Temperature KW - Humidity KW - Military KW - Protective equipment KW - Working conditions KW - Occupational health KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808660634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Comparison+of+estimated+core+body+temperature+measured+with+the+BioHarness+and+rectal+temperature+under+several+heat+stress+conditions&rft.au=Seo%2C+Yongsuk%3BDiLeo%2C+Travis%3BPowell%2C+Jeffrey+B%3BKim%2C+Jung-Hyun%3BRoberge%2C+Raymond+J%3BCoca%2C+Aitor&rft.aulast=Seo&rft.aufirst=Yongsuk&rft.date=2016-08-02&rft.volume=13&rft.issue=8&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1161199 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - High temperature; Firefighter services; Heart rate; Physiology; Temperature; Heat tolerance; Humidity; Military; Protective equipment; Working conditions; Occupational health DO - http://dx.doi.org/10.1080/15459624.2016.1161199 ER - TY - JOUR T1 - Detecting bacteria contamination on medical device surfaces using an integrated fiber-optic mid-infrared spectroscopy sensing method AN - 1846410354; PQ0002968536 AB - Bacterial contamination on medical device surfaces is a critical public health concern. In order to detect bacteria on medical device surface, alternative methods for quantitative, accurate, easy-to-use, and real-time detection and identification of microorganism contamination are needed. We have recently presented a novel proof-of-concept platform for non-contact, label-free and real-time detection of surface contamination employing a fiber-optic Fourier transform infrared (FO-FTIR) spectroscopy sensing methodology in the mid-infrared (mid-IR) spectral range of 1.6-12 mu m. In the present study, we demonstrate the detection capability and sensitivity of the integrated FO-FTIR approach using four species of commonly encountered bacteria: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Streptococcus pneumoniae. FO-FTIR combined with multivariate approaches such as hierarchical clustering and principal component analysis provided specific mid-IR spectral differentiation of the four microorganisms including when the sample contained mixtures of bacteria types. To assess the sensitivity of the FO-FTIR platform, bacteria samples were prepared at 109 colony forming unit (CFU)/ mu L and then serially diluted 1:10 eight times. The salient findings of this investigation showed that the integrated FO-FTIR based sensor can detect the presence of the bacteria at concentrations between 103 and 104 CFU/2 mu L, producing unique bacteria signatures with high reproducibility. The advanced features of this sensing method in terms of sensitivity, specificity and repeatability employing non-contact, label-free, and real-time approaches, demonstrate its potential use as an alternative effective screening tool for routine monitoring of bacterial contaminated surfaces. JF - Sensors and Actuators B: Chemical AU - Hassan, Moinuddin AU - Gonzalez, Elizabeth AU - Hitchins, Victoria AU - Ilev, Ilko AD - Optical Therapeutics and Medical Nanophotonics Laboratory, Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, USA Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 646 EP - 654 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 231 SN - 0925-4005, 0925-4005 KW - Microbiology Abstracts B: Bacteriology KW - Bacteria contamination KW - Fourier transform infrared (FTIR) spectroscopy KW - Fiber-optics sensors KW - Medical devices KW - Principal component analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846410354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sensors+and+Actuators+B%3A+Chemical&rft.atitle=Detecting+bacteria+contamination+on+medical+device+surfaces+using+an+integrated+fiber-optic+mid-infrared+spectroscopy+sensing+method&rft.au=Hassan%2C+Moinuddin%3BGonzalez%2C+Elizabeth%3BHitchins%2C+Victoria%3BIlev%2C+Ilko&rft.aulast=Hassan&rft.aufirst=Moinuddin&rft.date=2016-08-01&rft.volume=231&rft.issue=&rft.spage=646&rft.isbn=&rft.btitle=&rft.title=Sensors+and+Actuators+B%3A+Chemical&rft.issn=09254005&rft_id=info:doi/10.1016%2Fj.snb.2016.03.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2016-12-07 DO - http://dx.doi.org/10.1016/j.snb.2016.03.044 ER - TY - JOUR T1 - Variable Lifting Index (VLI): A New Method for Evaluating Variable Lifting Tasks AN - 1827890587; PQ0003686888 AB - Objective: We seek to develop a new approach for analyzing the physical demands of highly variable lifting tasks through an adaptation of the Revised NIOSH (National Institute for Occupational Safety and Health) Lifting Equation (RNLE) into a Variable Lifting Index (VLI). Background: There are many jobs that contain individual lifts that vary from lift to lift due to the task requirements. The NIOSH Lifting Equation is not suitable in its present form to analyze variable lifting tasks. Method: In extending the prior work on the VLI, two procedures are presented to allow users to analyze variable lifting tasks. One approach involves the sampling of lifting tasks performed by a worker over a shift and the calculation of the Frequency Independent Lift Index (FILI) for each sampled lift and the aggregation of the FILI values into six categories. The Composite Lift Index (CLI) equation is used with lifting index (LI) category frequency data to calculate the VLI. The second approach employs a detailed systematic collection of lifting task data from production and/or organizational sources. The data are organized into simplified task parameter categories and further aggregated into six FILI categories, which also use the CLI equation to calculate the VLI. Results: The two procedures will allow practitioners to systematically employ the VLI method to a variety of work situations where highly variable lifting tasks are performed. Conclusions: The scientific basis for the VLI procedure is similar to that for the CLI originally presented by NIOSH; however, the VLI method remains to be validated. Application: The VLI method allows an analyst to assess highly variable manual lifting jobs in which the task characteristics vary from lift to lift during a shift. JF - Human Factors AU - Waters, Thomas AU - Occhipinti, Enrico AU - Colombini, Daniela AU - Alvarez-Casado, Enrique AU - Fox, Robert AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio, epmenrico@tiscali.it Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 695 EP - 711 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 USA VL - 58 IS - 5 SN - 0018-7208, 0018-7208 KW - Health & Safety Science Abstracts KW - biomechanics KW - physical ergonomics KW - job analysis KW - manual materials handling KW - risk assessment KW - Adaptability KW - Occupational safety KW - Human factors KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827890587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Factors&rft.atitle=Variable+Lifting+Index+%28VLI%29%3A+A+New+Method+for+Evaluating+Variable+Lifting+Tasks&rft.au=Waters%2C+Thomas%3BOcchipinti%2C+Enrico%3BColombini%2C+Daniela%3BAlvarez-Casado%2C+Enrique%3BFox%2C+Robert&rft.aulast=Waters&rft.aufirst=Thomas&rft.date=2016-08-01&rft.volume=58&rft.issue=5&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Human+Factors&rft.issn=00187208&rft_id=info:doi/10.1177%2F0018720815612256 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 20 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Adaptability; Occupational safety; Human factors DO - http://dx.doi.org/10.1177/0018720815612256 ER - TY - JOUR T1 - Linear combination methods to improve diagnostic/prognostic accuracy on future observations AN - 1814271964 AB - Multiple diagnostic tests or biomarkers can be combined to improve diagnostic accuracy. The problem of finding the optimal linear combinations of biomarkers to maximise the area under the receiver operating characteristic curve has been extensively addressed in the literature. The purpose of this article is threefold: (1) to provide an extensive review of the existing methods for biomarker combination; (2) to propose a new combination method, namely, the nonparametric stepwise approach; (3) to use leave-one-pair-out cross-validation method, instead of re-substitution method, which is overoptimistic and hence might lead to wrong conclusion, to empirically evaluate and compare the performance of different linear combination methods in yielding the largest area under receiver operating characteristic curve. A data set of Duchenne muscular dystrophy was analysed to illustrate the applications of the discussed combination methods. JF - Statistical Methods in Medical Research AU - Kang, Le AU - Liu, Aiyi AU - Tian, Lili AD - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA ; Biostatistics and Bioinformatics Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA ; Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY, USA ; Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 1359 EP - 1380 CY - London PB - Sage Publications Ltd. VL - 25 IS - 4 SN - 0962-2802 KW - Medical Sciences KW - Multiple biomarkers KW - receiver operating characteristic curve KW - area under the receiver operating characteristic curve KW - linear combination KW - diagnostic/prognostic accuracy KW - Accuracy KW - Biological markers KW - Duchenne muscular dystrophy KW - Prognosis KW - Validation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814271964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Linear+combination+methods+to+improve+diagnostic%2Fprognostic+accuracy+on+future+observations&rft.au=Kang%2C+Le%3BLiu%2C+Aiyi%3BTian%2C+Lili&rft.aulast=Kang&rft.aufirst=Le&rft.date=2016-08-01&rft.volume=25&rft.issue=4&rft.spage=1359&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213481053 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2013 N1 - Last updated - 2016-08-27 DO - http://dx.doi.org/10.1177/0962280213481053 ER - TY - JOUR T1 - Statistical methods for multivariate meta-analysis of diagnostic tests: An overview and tutorial AN - 1814271426 AB - In this article, we present an overview and tutorial of statistical methods for meta-analysis of diagnostic tests under two scenarios: (1) when the reference test can be considered a gold standard and (2) when the reference test cannot be considered a gold standard. In the first scenario, we first review the conventional summary receiver operating characteristics approach and a bivariate approach using linear mixed models. Both approaches require direct calculations of study-specific sensitivities and specificities. We next discuss the hierarchical summary receiver operating characteristics curve approach for jointly modeling positivity criteria and accuracy parameters, and the bivariate generalized linear mixed models for jointly modeling sensitivities and specificities. We further discuss the trivariate generalized linear mixed models for jointly modeling prevalence, sensitivities and specificities, which allows us to assess the correlations among the three parameters. These approaches are based on the exact binomial distribution and thus do not require an ad hoc continuity correction. Lastly, we discuss a latent class random effects model for meta-analysis of diagnostic tests when the reference test itself is imperfect for the second scenario. A number of case studies with detailed annotated SAS code in MIXED and NLMIXED procedures are presented to facilitate the implementation of these approaches. JF - Statistical Methods in Medical Research AU - Ma, Xiaoye AU - Nie, Lei AU - Cole, Stephen R AU - Chu, Haitao AD - Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA ; Division of Biometrics IV, Office of Biometrics/OTS/CDER /FDA, Silver Spring, MD, USA ; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA ; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 1596 EP - 1619 CY - London PB - Sage Publications Ltd. VL - 25 IS - 4 SN - 0962-2802 KW - Medical Sciences KW - Meta-analysis KW - diagnostic test KW - gold standard KW - generalized linear mixed models KW - Accuracy KW - Analysis KW - Approaches KW - Parameters KW - Positive affect KW - Random effects KW - Sensitivity KW - Statistical methods KW - Diagnostic tests KW - Binomial distribution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1814271426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Statistical+methods+for+multivariate+meta-analysis+of+diagnostic+tests%3A+An+overview+and+tutorial&rft.au=Ma%2C+Xiaoye%3BNie%2C+Lei%3BCole%2C+Stephen+R%3BChu%2C+Haitao&rft.aulast=Ma&rft.aufirst=Xiaoye&rft.date=2016-08-01&rft.volume=25&rft.issue=4&rft.spage=1596&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213492588 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2013 N1 - Last updated - 2016-08-27 DO - http://dx.doi.org/10.1177/0962280213492588 ER - TY - JOUR T1 - Transmissible Plasmid Containing Salmonella enterica Heidelberg Isolates Modulate Cytokine Production During Early Stage of Interaction with Intestinal Epithelial Cells AN - 1811894240; PQ0003547551 AB - The variation in cytokine production during bacterial invasion of human intestinal epithelial cells (IECs) is a contributing factor for progression of the infection. A few Salmonella enterica Heidelberg strains isolated from poultry products harbor transmissible plasmids (TPs), including those that encode a type-IV secretion system. Earlier, we showed that these TPs are responsible for increased virulence during infection. This study examines the potential role of these TPs in cytokine production in IECs. This study showed that S. Heidelberg strains containing TPs (we refer as virulent strains) caused decreased interleukin (IL)-10 production in IECs after 1h infection. The virulent strains induced a high level of tumor necrosis factor- alpha production under identical conditions. The virulent strains of S. Heidelberg also altered the production of IL-2, IL-17, and granulocyte macrophage colony-stimulating factor compared to an avirulent strain. As a part of infection, bacteria cross the epithelial barrier and encounter intestinal macrophages. Hence, we examined the cytotoxic mechanism of strains of S. Heidelberg in macrophages. Scanning electron microscopy showed cell necrosis occurs during the early stage of infection. In conclusion, virulent S. Heidelberg strains were able to modify the host cytokine profile during the early stages of infection and also caused necrosis in macrophages. JF - DNA and Cell Biology AU - Gokulan, Kuppan AU - Khare, Sangeeta AU - Williams, Katherine AU - Foley, Steven L AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 443 EP - 453 PB - Mary Ann Liebert, Inc., 140 Huguenot Street New Rochelle NY 10801 United States VL - 35 IS - 8 SN - 1044-5498, 1044-5498 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Scanning electron microscopy KW - Epithelial cells KW - Poultry KW - Interleukin 2 KW - Granulocyte-macrophage colony-stimulating factor KW - Plasmids KW - Infection KW - Virulence KW - Cytotoxicity KW - Salmonella enterica KW - Interleukin 17 KW - Intestine KW - Cytokines KW - Tumor necrosis factor- alpha KW - J 02350:Immunology KW - N 14845:Miscellaneous KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811894240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+and+Cell+Biology&rft.atitle=Transmissible+Plasmid+Containing+Salmonella+enterica+Heidelberg+Isolates+Modulate+Cytokine+Production+During+Early+Stage+of+Interaction+with+Intestinal+Epithelial+Cells&rft.au=Gokulan%2C+Kuppan%3BKhare%2C+Sangeeta%3BWilliams%2C+Katherine%3BFoley%2C+Steven+L&rft.aulast=Gokulan&rft.aufirst=Kuppan&rft.date=2016-08-01&rft.volume=35&rft.issue=8&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=DNA+and+Cell+Biology&rft.issn=10445498&rft_id=info:doi/10.1089%2Fdna.2015.3142 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 63 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Scanning electron microscopy; Poultry; Interleukin 2; Granulocyte-macrophage colony-stimulating factor; Infection; Plasmids; Virulence; Cytotoxicity; Interleukin 17; Intestine; Cytokines; Tumor necrosis factor- alpha; Salmonella enterica DO - http://dx.doi.org/10.1089/dna.2015.3142 ER - TY - JOUR T1 - Exploration of testing practices and population characteristics support an increase in chlamydia positivity in Tasmania between 2001 and 2010 AN - 1811882020; PQ0003549707 AB - Objective: The proportion of positive chlamydia tests in young people in Tasmania increased significantly between 2001 and 2010. While female positivity rates increased steadily, male positivity rose steeply to 2005 then stabilised. Crude positivity rates can be influenced by a variety of factors making interpretation difficult. Unique Tasmanian datasets were used to explore whether symptom status, reason for testing or sexual exposure could explain the observed positivity trends. Methods: Population-level chlamydia positivity rates in Tasmania over a 10-year period were compared with surveillance data collected on people aged 15 to 29 years notified with chlamydia. Results: The proportion of asymptomatic chlamydia cases increased, with the largest increase in males aged 15 to 19 years (28%). Opportunistic testing of cases increased (greatest in males, range 17-32%). Sexual exposure remained consistent. Conclusions: After allowing for any changes in sexual exposure, symptom status and reason for testing, an increase in chlamydia positivity occurred over the 10 years. Healthcare providers have increased chlamydia testing in high-risk groups. Implications: Monitoring chlamydia testing patterns and positivity rates at a population level is a step forward in surveillance practices. Targeted surveys provide valuable information to supplement routine surveillance data. JF - Australian and New Zealand Journal of Public Health AU - Stephens, Nicola AU - Coleman, David AU - Shaw, Kelly AU - O'Sullivan, Maree AU - Vally, Hassan AU - Venn, Alison AD - Communicable Disease Epidemiology and Surveillance, Department of Health and Human Services Victoria. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 362 EP - 367 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 40 IS - 4 SN - 1326-0200, 1326-0200 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - Data processing KW - Population characteristics KW - PSE, New Zealand KW - Risk groups KW - Population levels KW - PSE, Australia, Tasmania KW - Sexually transmitted diseases KW - Medical personnel KW - Chlamydia KW - Public health KW - J 02400:Human Diseases KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811882020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Australian+and+New+Zealand+Journal+of+Public+Health&rft.atitle=Exploration+of+testing+practices+and+population+characteristics+support+an+increase+in+chlamydia+positivity+in+Tasmania+between+2001+and+2010&rft.au=Stephens%2C+Nicola%3BColeman%2C+David%3BShaw%2C+Kelly%3BO%27Sullivan%2C+Maree%3BVally%2C+Hassan%3BVenn%2C+Alison&rft.aulast=Stephens&rft.aufirst=Nicola&rft.date=2016-08-01&rft.volume=40&rft.issue=4&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Australian+and+New+Zealand+Journal+of+Public+Health&rft.issn=13260200&rft_id=info:doi/10.1111%2F1753-6405.12502 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Data processing; Risk groups; Population levels; Public health; Population characteristics; Medical personnel; Sexually transmitted diseases; Chlamydia; PSE, New Zealand; PSE, Australia, Tasmania DO - http://dx.doi.org/10.1111/1753-6405.12502 ER - TY - JOUR T1 - Effects of Intertidal Harvest Practices on Levels of Vibrio parahaemolyticus and Vibrio vulnificus Bacteria in Oysters AN - 1811880442; PQ0003548963 AB - Vibrio parahaemolyticus and Vibrio vulnificus can grow rapidly in shellfish subjected to ambient air conditions, such as during intertidal exposure. In this study, levels of total and pathogenic (tdh+ and/or trh+) V. parahaemolyticus and total V. vulnificus were determined in oysters collected from two study locations where intertidal harvest practices are common. Samples were collected directly off intertidal flats, after exposure (ambient air [WashingtonState] or refrigerated [NewJersey]), and after reimmersion by natural tidal cycles. Samples were processed using a most-probable-number (MPN) real-time PCR method for total and pathogenic V. parahaemolyticus or V. vulnificus. In Washington State, the mean levels of V. parahaemolyticus increased 1.38 log MPN/g following intertidal exposure and dropped 1.41 log MPN/g after reimmersion for 1 day, but the levels were dependent upon the container type utilized. Pathogenic V. parahaemolyticus levels followed a similar trend. However, V. vulnificus levels increased 0.10 log MPN/g during intertidal exposure in Washington but decreased by >1 log MPN/g after reimmersion. In New Jersey, initial levels of all vibrios studied were not significantly altered during the refrigerated sorting and containerizing process. However, there was an increase in levels after the first day of reimmersion by 0.79, 0.72, 0.92, and 0.71 log MPN/g for total, tdh+ and trh+ V. parahaemolyticus, and V. vulnificus, respectively. The levels of all targets decreased to those similar to background after a second day of reimmersion. These data indicate that the intertidal harvest and handling practices for oysters that were studied in Washington and New Jersey do not increase the risk of illness from V. parahaemolyticus or V. vulnificus. IMPORTANCE Vibrio parahaemolyticus and Vibrio vulnificus are the leading causes of seafood-associated infectious morbidity and mortality in the United States. Vibrio spp. can grow rapidly in shellfish subjected to ambient air conditions, such as during periods of intertidal exposure. When oysters are submersed with the incoming tide, the vibrios can be purged. However, data on the rates of increase and purging during intertidal harvest are scarce, which limits the accuracy of risk assessments. The objective of this study was to help fill these data gaps by determining the levels of total and pathogenic (tdh+ and/or trh+) V. parahaemolyticus and V. vulnificus in oysters from two locations where intertidal harvest practices are common, using the current industry practices. The data generated provide insight into the responses of Vibrio spp. to relevant practices of the industry and public health, which can be incorporated into risk management decisions. JF - Antimicrobial Agents & Chemotherapy AU - Jones, J L AU - Kinsey, T P AU - Johnson, L W AU - Porso, R AU - Friedman, B AU - Curtis, M AU - Wesighan, P AU - Schuster, R AU - Bowers, J C AD - << + $0, Jessica.Jones@fda.hhs.gov. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 4517 EP - 4522 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 15 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Risk assessment KW - Mortality KW - Vibrio KW - Data processing KW - Vibrio vulnificus KW - Vibrio parahaemolyticus KW - Polymerase chain reaction KW - Tides KW - Morbidity KW - Public health KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811880442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Effects+of+Intertidal+Harvest+Practices+on+Levels+of+Vibrio+parahaemolyticus+and+Vibrio+vulnificus+Bacteria+in+Oysters&rft.au=Jones%2C+J+L%3BKinsey%2C+T+P%3BJohnson%2C+L+W%3BPorso%2C+R%3BFriedman%2C+B%3BCurtis%2C+M%3BWesighan%2C+P%3BSchuster%2C+R%3BBowers%2C+J+C&rft.aulast=Jones&rft.aufirst=J&rft.date=2016-08-01&rft.volume=82&rft.issue=15&rft.spage=4517&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00721-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 30 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mortality; Data processing; Polymerase chain reaction; Morbidity; Tides; Public health; Vibrio; Vibrio vulnificus; Vibrio parahaemolyticus DO - http://dx.doi.org/10.1128/AEM.00721-16 ER - TY - JOUR T1 - Birth defects in infants born to employees of a microelectronics and business machine manufacturing facility. AN - 1811300414; 27224896 AB - Concerns about solvent releases from a microelectronics/business machine manufacturing facility in upstate New York led to interest in the health of former workers, including this investigation of birth defects in children of male and female employees. Children born 1983 to 2001 to facility employees were enumerated and matched to New York State's Congenital Malformations Registry. Reported structural birth defects were compared with numbers expected from state rates (excluding New York City), generating standardized prevalence ratios (SPRs). Exposure assessors classified employees as ever/never potentially exposed at the facility to metals, chlorinated hydrocarbons, and other hydrocarbons during windows critical to organogenesis (female workers) or spermatogenesis (male workers). Among workers, adjusted prevalence ratios were generated to evaluate associations between potential exposures and specific birth defects. External comparisons for structural defects were at expectation for infants of male workers (SPR = 1.01; 95% confidence interval [CI], 0.77-1.29; n = 60) and lower for births to female workers (SPR = 0.84; 95% CI, 0.50-1.33; n = 18). Among full-term infants of male workers, ventricular septal defects (VSDs) were somewhat elevated compared with the general population (SPR = 1.58; 95% CI, 0.99-2.39; n = 22). Within the cohort, potential paternal metal exposure was associated with increased VSD risk (adjusted prevalence ratio = 2.70; 95% CI, = 1.09-6.67; n = 7). While overall SPRs were near expectation, paternal exposure to metals (primarily lead) appeared to be associated with increased VSD risk in infants. Take-home of occupational exposures, nonoccupational exposures, and chance could not be ruled out as causes. Case numbers for many defects were small, limiting assessment of the role of occupational exposures. Birth Defects Research (Part A) 106:696-707, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Silver, Sharon R AU - Pinkerton, Lynne E AU - Rocheleau, Carissa M AU - Deddens, James A AU - Michalski, Adrian M AU - Van Zutphen, Alissa R AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio. ; New York State Department of Health, Bureau of Environmental and Occupational Epidemiology, Albany, New York. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 696 EP - 707 VL - 106 IS - 8 KW - Index Medicus KW - chlorinated hydrocarbons KW - metals KW - lead KW - congenital heart defects KW - occupational exposure KW - paternal exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811300414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Birth+defects+in+infants+born+to+employees+of+a+microelectronics+and+business+machine+manufacturing+facility.&rft.au=Silver%2C+Sharon+R%3BPinkerton%2C+Lynne+E%3BRocheleau%2C+Carissa+M%3BDeddens%2C+James+A%3BMichalski%2C+Adrian+M%3BVan+Zutphen%2C+Alissa+R&rft.aulast=Silver&rft.aufirst=Sharon&rft.date=2016-08-01&rft.volume=106&rft.issue=8&rft.spage=696&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23520 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23520 ER - TY - JOUR T1 - Regulation of striatal astrocytic receptor for advanced glycation end-products variants in an early stage of experimental Parkinson's disease. AN - 1810555325; 27221633 AB - Convincing evidence indicates that advanced glycation end-products and danger-associated protein S100B play a role in Parkinson's disease (PD). These agents operate through the receptor for advanced glycation end-products (RAGE), which displays distinct isoforms playing protective/deleterious effects. However, the nature of RAGE variants has been overlooked in PD studies. Hence, we attempted to characterize RAGE regulation in early stages of PD striatal pathology. A neurotoxin-based rodent model of PD was used in this study, through administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to C57BL/6 mice. Animals were killed 6 h post-MPTP to assess S100B/RAGE contents (RT-qPCR, ELISA) and RAGE isoform density (WB) and cellular distribution (immunohistochemistry). Dopaminergic and gliotic status were also mapped (HPLC-ED, WB, immunohistochemistry). At this preliminary stage of MPTP-induced PD in mice, RAGE inhibitory isoforms were increased whereas full-length RAGE was not affected. This putative cytoprotective RAGE phenotype paired an inflammatory and pro-oxidant setting fueling DAergic denervation. Increased RAGE inhibitory variants occur in astrocytes showing higher S100B density but no overt signs of hypertrophy or NF-κB activation, a canonical effector of RAGE. These findings expand our understanding of the toxic effect of MPTP on striatum and offer first in vivo evidence of RAGE being a responder in early stages of astrogliosis dynamics, supporting a protective rather tissue-destructive phenotype of RAGE in the initial phase of PD degeneration. These data lay the groundwork for future studies on the relevance of astrocytic RAGE in DAergic neuroprotection strategies. We report increased antagonistic RAGE variants paralleling S100B up-regulation in early stages of MPTP-induced astrogliosis dynamics . We propose that selective RAGE regulation reflects a self-protective mechanism to maintain low levels of RAGE ligands , preventing long-term inflammation and oxidative stress arising from sustained ligands/flRAGE activation . Understanding loss of RAGE protective response to stress may provide new therapeutic options to halt or slow down dopaminergic axonopathy and, ultimately, neuronal death . © 2016 International Society for Neurochemistry. JF - Journal of neurochemistry AU - Viana, Sofia D AU - Valero, Jorge AU - Rodrigues-Santos, Paulo AU - Couceiro, Patrícia AU - Silva, Andréa M AU - Carvalho, Félix AU - Ali, Syed F AU - Fontes-Ribeiro, Carlos A AU - Pereira, Frederico C AD - Laboratory of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. ; CNC.IBILI - University of Coimbra, Coimbra, Portugal. ; Institute of Immunology - Faculty of Medicine, University of Coimbra, Coimbra, Portugal. ; Immunology and Oncology Laboratory, Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Coimbra, Portugal. ; UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center of Toxicological Research/Food and Drug Administration, Jefferson, Arkansas, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 598 EP - 609 VL - 138 IS - 4 KW - Index Medicus KW - S100B KW - MPTP KW - striatum KW - RAGE isoforms KW - astrocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1810555325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Regulation+of+striatal+astrocytic+receptor+for+advanced+glycation+end-products+variants+in+an+early+stage+of+experimental+Parkinson%27s+disease.&rft.au=Viana%2C+Sofia+D%3BValero%2C+Jorge%3BRodrigues-Santos%2C+Paulo%3BCouceiro%2C+Patr%C3%ADcia%3BSilva%2C+Andr%C3%A9a+M%3BCarvalho%2C+F%C3%A9lix%3BAli%2C+Syed+F%3BFontes-Ribeiro%2C+Carlos+A%3BPereira%2C+Frederico+C&rft.aulast=Viana&rft.aufirst=Sofia&rft.date=2016-08-01&rft.volume=138&rft.issue=4&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fjnc.13682 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/jnc.13682 ER - TY - JOUR T1 - Combined Effects of High-Dose Bisphenol A and Oxidizing Agent (KBrO3) on Cellular Microenvironment, Gene Expression, and Chromatin Structure of Ku70-deficient Mouse Embryonic Fibroblasts. AN - 1809046512; 27082013 AB - Exposure to bisphenol A (BPA) has been reported to alter global gene expression, induce epigenetic modifications, and interfere with complex regulatory networks of cells. In addition to these reprogramming events, we have demonstrated that BPA exposure generates reactive oxygen species and promotes cellular survival when co-exposed with the oxidizing agent potassium bromate (KBrO3). We determined the cellular microenvironment changes induced by co-exposure of BPA and KBrO3 versus either agent alone. Ku70-deficient cells were exposed to 150 μM BPA, 20 mM KBrO3, or co-exposed to both agents. Four and 24 hr post-damage initiation by KBrO3, with BPA-only samples timed to coincide with these designated time points, we performed whole-genome microarray analysis and evaluated chromatin structure, DNA lesion load, glutathione content, and intracellular pH. We found that 4 hr post-damage initiation, BPA exposure and co-exposure transiently condensed chromatin compared with untreated and KBrO3-only treated cells; the transcription of DNA repair proteins was also reduced. At this time point, BPA exposure and co-exposure also reduced the change in intracellular pH observed after treatment with KBrO3 alone. Twenty-four hours post-damage initiation, BPA-exposed cells showed less condensed chromatin than cells treated with KBrO3 alone; the intracellular pH of the co-exposed cells was significantly reduced compared with untreated and KBrO3-treated cells; and significant up-regulation of DNA repair proteins was observed after co-exposure. These results support the induction of an adaptive response by BPA co-exposure that alters the microcellular environment and modulates DNA repair. Further work is required to determine whether BPA induces similar DNA lesions in vivo at environmentally relevant doses; however, in the Ku70-deficient mouse embryonic fibroblasts, exposure to a high dose of BPA was associated with changes in the cellular microenvironment that may promote survival. Gassman NR, Coskun E, Jaruga P, Dizdaroglu M, Wilson SH. 2016. Combined effects of high-dose bisphenol A and oxidizing agent (KBrO3) on cellular microenvironment, gene expression, and chromatin structure of Ku70-deficient mouse embryonic fibroblasts. Environ Health Perspect 124:1241-1252; http://dx.doi.org/10.1289/EHP237. JF - Environmental health perspectives AU - Gassman, Natalie R AU - Coskun, Erdem AU - Jaruga, Pawel AU - Dizdaroglu, Miral AU - Wilson, Samuel H AD - Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1241 EP - 1252 VL - 124 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809046512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Combined+Effects+of+High-Dose+Bisphenol+A+and+Oxidizing+Agent+%28KBrO3%29+on+Cellular+Microenvironment%2C+Gene+Expression%2C+and+Chromatin+Structure+of+Ku70-deficient+Mouse+Embryonic+Fibroblasts.&rft.au=Gassman%2C+Natalie+R%3BCoskun%2C+Erdem%3BJaruga%2C+Pawel%3BDizdaroglu%2C+Miral%3BWilson%2C+Samuel+H&rft.aulast=Gassman&rft.aufirst=Natalie&rft.date=2016-08-01&rft.volume=124&rft.issue=8&rft.spage=1241&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2FEHP237 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/EHP237 ER - TY - JOUR T1 - Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data. AN - 1809046364; 26978842 AB - Diabetes and obesity are major threats to public health in the United States and abroad. Understanding the role that chemicals in our environment play in the development of these conditions is an emerging issue in environmental health, although identifying and prioritizing chemicals for testing beyond those already implicated in the literature is challenging. This review is intended to help researchers generate hypotheses about chemicals that may contribute to diabetes and to obesity-related health outcomes by summarizing relevant findings from the U.S. Environmental Protection Agency (EPA) ToxCast™ high-throughput screening (HTS) program. Our aim was to develop new hypotheses around environmental chemicals of potential interest for diabetes- or obesity-related outcomes using high-throughput screening data. We identified ToxCast™ assay targets relevant to several biological processes related to diabetes and obesity (insulin sensitivity in peripheral tissue, pancreatic islet and β cell function, adipocyte differentiation, and feeding behavior) and presented chemical screening data against those assay targets to identify chemicals of potential interest. The results of this screening-level analysis suggest that the spectrum of environmental chemicals to consider in research related to diabetes and obesity is much broader than indicated by research papers and reviews published in the peer-reviewed literature. Testing hypotheses based on ToxCast™ data will also help assess the predictive utility of this HTS platform. More research is required to put these screening-level analyses into context, but the information presented in this review should facilitate the development of new hypotheses. Auerbach S, Filer D, Reif D, Walker V, Holloway AC, Schlezinger J, Srinivasan S, Svoboda D, Judson R, Bucher JR, Thayer KA. 2016. Prioritizing environmental chemicals for obesity and diabetes outcomes research: a screening approach using ToxCast™ high-throughput data. Environ Health Perspect 124:1141-1154; http://dx.doi.org/10.1289/ehp.1510456. JF - Environmental health perspectives AU - Auerbach, Scott AU - Filer, Dayne AU - Reif, David AU - Walker, Vickie AU - Holloway, Alison C AU - Schlezinger, Jennifer AU - Srinivasan, Supriya AU - Svoboda, Daniel AU - Judson, Richard AU - Bucher, John R AU - Thayer, Kristina A AD - Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1141 EP - 1154 VL - 124 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1809046364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Prioritizing+Environmental+Chemicals+for+Obesity+and+Diabetes+Outcomes+Research%3A+A+Screening+Approach+Using+ToxCast%E2%84%A2+High-Throughput+Data.&rft.au=Auerbach%2C+Scott%3BFiler%2C+Dayne%3BReif%2C+David%3BWalker%2C+Vickie%3BHolloway%2C+Alison+C%3BSchlezinger%2C+Jennifer%3BSrinivasan%2C+Supriya%3BSvoboda%2C+Daniel%3BJudson%2C+Richard%3BBucher%2C+John+R%3BThayer%2C+Kristina+A&rft.aulast=Auerbach&rft.aufirst=Scott&rft.date=2016-08-01&rft.volume=124&rft.issue=8&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1510456 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-03 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1289/ehp.1510456 ER - TY - JOUR T1 - Development and calibration of a dietary nitrate and nitrite database in the NIH-AARP Diet and Health Study AN - 1808735443; PQ0003406816 AB - Nitrate and nitrite are probable human carcinogens when ingested under conditions that increase the formation of N-nitroso compounds. There have been limited efforts to develop US databases of dietary nitrate and nitrite for standard FFQ. Here we describe the development of a dietary nitrate and nitrite database and its calibration. We analysed data from a calibration study of 1942 members of the NIH-AARP (NIH-AARP, National Institutes of Health-AARP) Diet and Health Study who reported all foods and beverages consumed on the preceding day in two non-consecutive 24 h dietary recalls (24HR) and completed an FFQ. Based on a literature review, we developed a database of nitrate and nitrite contents for foods reported on these 24HR and for food category line items on the FFQ. We calculated daily nitrate and nitrite intakes for both instruments, and used a measurement error model to compute correlation coefficients and attenuation factors for the FFQ-based intake estimates using 24HR-based values as reference data. FFQ-based median nitrate intake was 68.9 and 74.1 mg/d, and nitrite intake was 1.3 and 1.0 mg/d, in men and women, respectively. These values were similar to 24HR-based intake estimates. Energy-adjusted correlation coefficients between FFQ- and 24HR-based values for men and women respectively were 0.59 and 0.57 for nitrate and 0.59 and 0.58 for nitrite; energy-adjusted attenuation factors were 0.59 and 0.57 for nitrate and 0.47 and 0.38 for nitrite. The performance of the FFQ in assessing dietary nitrate and nitrite intakes is comparable to that for many other macro- and micronutrients. JF - Public Health Nutrition AU - Inoue-Choi, Maki AU - Virk-Baker, Mandeep K AU - Aschebrook-Kilfoy, Briseis AU - Cross, Amanda J AU - Subar, Amy F AU - Thompson, Frances E AU - Sinha, Rashmi AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9609 Medical Center Drive, 6E314, Rockville, MD 20850, USA, wardm@exchange.nih.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1934 EP - 1943 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 19 IS - 11 SN - 1368-9800, 1368-9800 KW - Health & Safety Science Abstracts; Calcium & Calcified Tissue Abstracts KW - Diets KW - Nitrate KW - Beverages KW - Data processing KW - Nitrates KW - Food KW - Carcinogens KW - Ingestion KW - Models KW - Public health KW - Databases KW - N-Nitroso compounds KW - Nitrites KW - Literature reviews KW - Micronutrients KW - Nitrite KW - Data bases KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808735443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Development+and+calibration+of+a+dietary+nitrate+and+nitrite+database+in+the+NIH-AARP+Diet+and+Health+Study&rft.au=Inoue-Choi%2C+Maki%3BVirk-Baker%2C+Mandeep+K%3BAschebrook-Kilfoy%2C+Briseis%3BCross%2C+Amanda+J%3BSubar%2C+Amy+F%3BThompson%2C+Frances+E%3BSinha%2C+Rashmi%3BWard%2C+Mary+H&rft.aulast=Inoue-Choi&rft.aufirst=Maki&rft.date=2016-08-01&rft.volume=19&rft.issue=11&rft.spage=1934&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS1368980015003407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 67 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Diets; Nitrate; Data processing; Beverages; Food; Carcinogens; Public health; Models; Databases; N-Nitroso compounds; Literature reviews; Micronutrients; Nitrite; Nitrates; Nitrites; Ingestion; Data bases DO - http://dx.doi.org/10.1017/S1368980015003407 ER - TY - JOUR T1 - Blockade of Nicotine and Cannabinoid Reinforcement and Relapse by a Cannabinoid CB1-Receptor Neutral Antagonist AM4113 and Inverse Agonist Rimonabant in Squirrel Monkeys AN - 1808660572; PQ0003465635 AB - Nicotine, the main psychoactive component of tobacco, and (-)- Delta super(9)-tetrahydroca nnabinol (THC), the main psychoactive ingredient in cannabis, play major roles in tobacco and marijuana dependence as reinforcers of drug-seeking and drug-taking behavior. Drugs that act as inverse agonists of cannabinoid CB1 receptors in the brain can attenuate the rewarding and abuse-related effects of nicotine and THC, but their clinical use is hindered by potentially serious side effects. The recently developed CB1-receptor neutral antagonists may provide an alternative therapeutic approach to nicotine and cannabinoid dependence. Here we compare attenuation of nicotine and THC reinforcement and reinstatement in squirrel monkeys by the CB1-receptor inverse agonist rimonabant and by the recently developed CB1-receptor neutral antagonist AM4113. Both rimonabant and AM4113 reduced two effects of nicotine and THC that play major roles in tobacco and marijuana dependence: (1) maintenance of high rates of drug-taking behavior, and (2) priming- or cue-induced reinstatement of drug-seeking behavior in abstinent subjects (models of relapse). In contrast, neither rimonabant nor AM4113 modified cocaine-reinforced or food-reinforced operant behavior under similar experimental conditions. However, both rimonabant and AM4113 reduced cue-induced reinstatement in monkeys trained to self-administer cocaine, suggesting the involvement of a common cannabinoid-mediated mechanism in the cue-induced reinstatement for different drugs of abuse. These findings point to CB1-receptor neutral antagonists as a new class of medications for treatment of both tobacco dependence and cannabis dependence. JF - Neuropsychopharmacology AU - Schindler, Charles W AU - Redhi, Godfrey H AU - Vemuri, Kiran AU - Makriyannis, Alexandros AU - Le Foll, Bernard AU - Bergman, Jack AU - Goldberg, Steven R AU - Justinova, Zuzana AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 2283 EP - 2293 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 41 IS - 9 SN - 0893-133X, 0893-133X KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Inverse agonists KW - Operant conditioning KW - Food KW - Brain KW - Drug abuse KW - Reinstatement KW - Tetrahydrocannabinol KW - Saimiri KW - Drug dependence KW - Nicotine KW - Reinforcement KW - Cannabis KW - Tobacco KW - Drug addiction KW - Cannabinoid CB1 receptors KW - Cocaine KW - Side effects KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808660572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology&rft.atitle=Blockade+of+Nicotine+and+Cannabinoid+Reinforcement+and+Relapse+by+a+Cannabinoid+CB1-Receptor+Neutral+Antagonist+AM4113+and+Inverse+Agonist+Rimonabant+in+Squirrel+Monkeys&rft.au=Schindler%2C+Charles+W%3BRedhi%2C+Godfrey+H%3BVemuri%2C+Kiran%3BMakriyannis%2C+Alexandros%3BLe+Foll%2C+Bernard%3BBergman%2C+Jack%3BGoldberg%2C+Steven+R%3BJustinova%2C+Zuzana&rft.aulast=Schindler&rft.aufirst=Charles&rft.date=2016-08-01&rft.volume=41&rft.issue=9&rft.spage=2283&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/10.1038%2Fnpp.2016.27 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Inverse agonists; Operant conditioning; Food; Brain; Drug abuse; Reinstatement; Tetrahydrocannabinol; Drug dependence; Nicotine; Tobacco; Cannabis; Reinforcement; Cocaine; Cannabinoid CB1 receptors; Drug addiction; Side effects; Saimiri DO - http://dx.doi.org/10.1038/npp.2016.27 ER - TY - JOUR T1 - Reported work-related injuries and illnesses among Hispanic workers: Results from an emergency department surveillance system follow-back survey AN - 1808656984; PQ0003466166 AB - Background Research suggests Hispanic workers underreport injuries/illnesses to their employer. Methods The National Electronic Injury Surveillance System-occupational supplement was used to conduct a follow-back study of workers treated in emergency departments (EDs) from June 2012 through December 2013. Results An estimated 448,000 (95%CI 230,000-665,000) Hispanic workers treated in EDs for a work-related injury or illness were represented by 362 completed interviews. Of these, an estimated 443,000 (95%CI 228,000-657,000) workers reported the injury or illness to their employer or were self-employed. The majority had not heard of workers' compensation. Only 10% expected workers' compensation to cover their medical payment while 62% expected payment to be covered by their employer. Conclusion We characterized our respondent workforce who reported their injury or illness. We determined that NEISS-Work data are not the most appropriate source to capture underreporting of work-related injuries and illnesses to employers among Hispanic workers. Am. J. Ind. Med. 59:621-629, 2016. JF - American Journal of Industrial Medicine AU - Tonozzi, Theresa R AU - Marsh, Suzanne M AU - Reichard, Audrey A AU - Bhandari, Ruchi AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, Morgantown, West Virginia. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 621 EP - 629 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 8 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Workers' compensation KW - Injuries KW - Ethnic groups KW - Emergency medical services KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808656984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Reported+work-related+injuries+and+illnesses+among+Hispanic+workers%3A+Results+from+an+emergency+department+surveillance+system+follow-back+survey&rft.au=Tonozzi%2C+Theresa+R%3BMarsh%2C+Suzanne+M%3BReichard%2C+Audrey+A%3BBhandari%2C+Ruchi&rft.aulast=Tonozzi&rft.aufirst=Theresa&rft.date=2016-08-01&rft.volume=59&rft.issue=8&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22606 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Injuries; Ethnic groups; Emergency medical services DO - http://dx.doi.org/10.1002/ajim.22606 ER - TY - JOUR T1 - Reverse Integration in Wheelchair Basketball: A Serious Leisure Perspective AN - 1808650715; PQ0003413396 AB - Wheelchair basketball is one of the most popular sport activities among persons with disabilities. The current study focuses on "reverse integration" (RI) groups of athletes with and without disabilities playing wheelchair basketball in Israel. A qualitative analysis approach was chosen to examine whether the able-bodied participants in RI wheelchair basketball training and competition identify their participation as a "serious leisure" (SL) activity, and to determine which additional insights could be gained about this activity from participants' perspectives. Eight male able-bodied participants, who have taken part in three Israeli wheelchair basketball leagues (divisions), were interviewed. All eight participants in this study played longer than a year. The findings revealed support for the SL premise within all six SL criteria. Participation of our informants was categorized within the establishment and maintenance phases. All participants reported sustained perseverance in spite of having to deal with significant challenges, including the physical strain and mental difficulties associated with the game, coping with dual roles of participation as player and coach, and finally, having to face the same economical and social barriers typically reported by athletes with disability. JF - Journal of Sport and Social Issues AU - Hutzler, Yeshayahu AU - Barda, Rachel AU - Mintz, Ahuva AU - Hayosh, Tali AD - 1 .Zinman College for Physical Education and Sport Sciences, Netanya, Israel, shayke@wincol.ac.il Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 338 EP - 360 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 40 IS - 4 SN - 0193-7235, 0193-7235 KW - Physical Education Index KW - sport games KW - disability KW - inclusion KW - able-bodied KW - Handicapped KW - Integration KW - Participation KW - Leisure KW - Basketball KW - Activities KW - Perspective KW - Wheelchairs KW - Athletes KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808650715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Sport+and+Social+Issues&rft.atitle=Reverse+Integration+in+Wheelchair+Basketball%3A+A+Serious+Leisure+Perspective&rft.au=Hutzler%2C+Yeshayahu%3BBarda%2C+Rachel%3BMintz%2C+Ahuva%3BHayosh%2C+Tali&rft.aulast=Hutzler&rft.aufirst=Yeshayahu&rft.date=2016-08-01&rft.volume=40&rft.issue=4&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Journal+of+Sport+and+Social+Issues&rft.issn=01937235&rft_id=info:doi/10.1177%2F0193723516632043 LA - English DB - Physical Education Index N1 - Date revised - 2016-07-01 N1 - Number of references - 46 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Integration; Handicapped; Leisure; Participation; Basketball; Activities; Perspective; Athletes; Wheelchairs DO - http://dx.doi.org/10.1177/0193723516632043 ER - TY - JOUR T1 - Characterizing emergency department patients who reported work-related injuries and illnesses AN - 1808642574; PQ0003466167 AB - Background Per a Congressional directive and funding, this study describes worker and workplace characteristics of emergency department (ED) patients who reported their injury/illness to their employer. The study also responds to Congress's request to enumerate injured/ill self-employed workers and workers with chronic conditions. Methods We conducted a follow-back study on injured/ill workers, including self-employed, identified from a national ED surveillance system from June 2012 through December 2013. Results An estimated 3,357,000 (95%CI: 2,516,000-4,199,000) workers treated in EDs reported their injury/illness to their employer or were self-employed. Of those, 202,000 (95%CI: 133,000-272,000) had a chronic condition. Of all reporters, excluding self-employed, 77% indicated they received instructions as to whom to report. Conclusion The study did not identify underreporting issues and revealed that medical records data may not be appropriate for assessing underreporting. Additional research is needed to examine workplace characteristics that encourage injury and illness reporting. Am. J. Ind. Med. 59:610-620, 2016. JF - American Journal of Industrial Medicine AU - Bhandari, Ruchi AU - Marsh, Suzanne M AU - Reichard, Audrey A AU - Tonozzi, Theresa R AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, Morgantown, West Virginia. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 610 EP - 620 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 8 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Injuries KW - Congress KW - Emergency medical services KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808642574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Characterizing+emergency+department+patients+who+reported+work-related+injuries+and+illnesses&rft.au=Bhandari%2C+Ruchi%3BMarsh%2C+Suzanne+M%3BReichard%2C+Audrey+A%3BTonozzi%2C+Theresa+R&rft.aulast=Bhandari&rft.aufirst=Ruchi&rft.date=2016-08-01&rft.volume=59&rft.issue=8&rft.spage=610&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22607 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Injuries; Congress; Emergency medical services DO - http://dx.doi.org/10.1002/ajim.22607 ER - TY - JOUR T1 - Genetic Characterization of Cronobacter sakazakii Recovered from the Environmental Surveillance Samples During a Sporadic Case Investigation of Foodborne Illness AN - 1808641619; PQ0003358891 AB - Cronobacter sakazakii is an opportunistic human-pathogenic bacterium known to cause acute meningitis and necrotizing enterocolitis in neonates and immunocompromised individuals. This human-pathogenic microorganism has been isolated from a variety of food and environmental samples, and has been also linked to foodborne outbreaks associated with powdered infant formula (PIF). The U.S. Food and Drug Administration have a policy of zero tolerance of these organisms in PIF. Thus, this agency utilizes the presence of these microorganisms as one of the criteria in implementing regulatory actions and assessing adulteration of food products of public health importance. In this study, we recovered two isolates of Cronobacter from the 91 environmental swab samples during an investigation of sporadic case of foodborne illness following conventional microbiological protocols. The isolated typical colonies were identified using VITEK2 and real-time PCR protocols. The recovered Cronobacter isolates were then characterized for species identification by sequencing the 16S rRNA locus. Further, multilocus sequence typing (MLST) was accomplished characterizing seven known C. sakazakii-specific MLST loci (atpD, fusA, glnS, gltB, gyrB, infB, and pps). Results of this study confirmed all of the recovered Cronobacter isolates from the environmental swab samples to be C. sakazakii. The MLST profile matched with the published profile of the complex 31 of C. sakazakii. Thus, rRNA and 7-loci MLST-based sequencing protocols are robust techniques for rapid detection and differentiation of Cronobacter species, and these molecular diagnostic tools can be used in implementing successful surveillance program and in the control and prevention of foodborne illness. JF - Current Microbiology AU - Sulaiman, Irshad M AU - Jacobs, Emily AU - Segars, Katharine AU - Simpson, Steven AU - Kerdahi, Khalil AD - Southeast Regional Laboratory, U.S. Food and Drug Administration, 60, Eighth Street, Atlanta, GA, 30309, USA, Irshad.Sulaiman@fda.hhs.gov Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 273 EP - 279 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 73 IS - 2 SN - 0343-8651, 0343-8651 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Infant formulas KW - DNA topoisomerase KW - Necrotizing enterocolitis KW - multilocus sequence typing KW - Meningitis KW - Public health KW - Differentiation KW - rRNA KW - Colonies KW - Microorganisms KW - Polymerase chain reaction KW - Neonates KW - rRNA 16S KW - G 07880:Human Genetics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808641619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Microbiology&rft.atitle=Genetic+Characterization+of+Cronobacter+sakazakii+Recovered+from+the+Environmental+Surveillance+Samples+During+a+Sporadic+Case+Investigation+of+Foodborne+Illness&rft.au=Sulaiman%2C+Irshad+M%3BJacobs%2C+Emily%3BSegars%2C+Katharine%3BSimpson%2C+Steven%3BKerdahi%2C+Khalil&rft.aulast=Sulaiman&rft.aufirst=Irshad&rft.date=2016-08-01&rft.volume=73&rft.issue=2&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Current+Microbiology&rft.issn=03438651&rft_id=info:doi/10.1007%2Fs00284-016-1059-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 43 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Infant formulas; DNA topoisomerase; Necrotizing enterocolitis; Public health; Meningitis; multilocus sequence typing; rRNA; Differentiation; Colonies; Microorganisms; Polymerase chain reaction; Neonates; rRNA 16S DO - http://dx.doi.org/10.1007/s00284-016-1059-z ER - TY - JOUR T1 - Mortality among workers exposed to toluene diisocyanate in the US polyurethane foam industry: Update and exposure-response analyses AN - 1808637979; PQ0003466168 AB - Background Mortality among 4,545 toluene diisocyante (TDI)-exposed workers was updated through 2011. The primary outcome of interest was lung cancer. Methods Life table analyses, including internal analyses by exposure duration and cumulative TDI exposure, were conducted. Results Compared with the US population, all cause and all cancer mortality was increased. Lung cancer mortality was increased but was not associated with exposure duration or cumulative TDI exposure. In post hoc analyses, lung cancer mortality was associated with employment duration in finishing jobs, but not in finishing jobs involving cutting polyurethane foam. Conclusions Dermal exposure, in contrast to inhalational exposure, to TDI is expected to be greater in finishing jobs and may play a role in the observed increase in lung cancer mortality. Limitations include the lack of smoking data, uncertainty in the exposure estimates, and exposure estimates that reflected inhalational exposure only. Am. J. Ind. Med. 59:630-643, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA JF - American Journal of Industrial Medicine AU - Pinkerton, Lynne E AU - Yiin, James H AU - Daniels, Robert D AU - Fent, Kenneth W AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 630 EP - 643 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 8 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Skin KW - Data processing KW - Life tables KW - Toluene KW - toluene diisocyanate KW - Employment KW - Foams KW - Cancer KW - Smoking KW - Workers KW - USA KW - Dose-response effects KW - polyurethane KW - Occupational exposure KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808637979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+among+workers+exposed+to+toluene+diisocyanate+in+the+US+polyurethane+foam+industry%3A+Update+and+exposure-response+analyses&rft.au=Pinkerton%2C+Lynne+E%3BYiin%2C+James+H%3BDaniels%2C+Robert+D%3BFent%2C+Kenneth+W&rft.aulast=Pinkerton&rft.aufirst=Lynne&rft.date=2016-08-01&rft.volume=59&rft.issue=8&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22622 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Skin; Toluene; Life tables; toluene diisocyanate; Foams; Workers; Smoking; Dose-response effects; polyurethane; Occupational exposure; Lung cancer; Employment; Cancer; USA DO - http://dx.doi.org/10.1002/ajim.22622 ER - TY - JOUR T1 - Using emergency department surveillance data to assess occupational injury and illness reporting by workers AN - 1808637817; PQ0003466172 AB - Objective Researchers from the National Institute for Occupational Safety and Health (NIOSH) share detailed methodologies from conducting two follow-back studies initiated in 2010 that were designed to assess whether workers reported their injuries and illnesses to their employers and to identify worker incentives and disincentives for reporting work-related injuries to employers. Methodology Study respondents were sampled from the National Electronic Injury Surveillance System occupational supplement (NEISS-Work), an emergency department-based surveillance system. Telephone interviews were used to collect information directly from workers. Outcomes Among persons treated in emergency departments who could be identified as working at the time of injury or illness, most reported their injury or illness to their employer. Our studies did not assess if these reported injuries and illnesses were recorded on the Occupational Safety and Health logs. Discussion Our approach suggests that emergency department-based surveillance data are limited in their utility to investigate underreporting among workers. Am. J. Ind. Med. 59:600-609, 2016. JF - American Journal of Industrial Medicine AU - Marsh, Suzanne M AU - Reichard, Audrey A AU - Bhandari, Ruchi AU - Tonozzi, Theresa R AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, Morgantown, West Virginia. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 600 EP - 609 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 8 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Workers KW - Data processing KW - Injuries KW - Occupational safety KW - Incentives KW - Emergency medical services KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808637817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Using+emergency+department+surveillance+data+to+assess+occupational+injury+and+illness+reporting+by+workers&rft.au=Marsh%2C+Suzanne+M%3BReichard%2C+Audrey+A%3BBhandari%2C+Ruchi%3BTonozzi%2C+Theresa+R&rft.aulast=Marsh&rft.aufirst=Suzanne&rft.date=2016-08-01&rft.volume=59&rft.issue=8&rft.spage=600&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22615 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Workers; Data processing; Injuries; Occupational safety; Incentives; Emergency medical services DO - http://dx.doi.org/10.1002/ajim.22615 ER - TY - JOUR T1 - EHP Highlights of the Past Year. AN - 1808607719; 27479990 JF - Environmental health perspectives AU - Darney, Sally Perreault AD - Environmental Health Perspectives, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/08/01/ PY - 2016 DA - 2016 Aug 01 SP - 1 VL - 124 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808607719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=EHP+Highlights+of+the+Past+Year.&rft.au=Darney%2C+Sally+Perreault&rft.aulast=Darney&rft.aufirst=Sally&rft.date=2016-08-01&rft.volume=124&rft.issue=8&rft.spage=A132&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2FEHP777 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/EHP777 ER - TY - JOUR T1 - The Exposome: Embracing the Complexity for Discovery in Environmental Health. AN - 1808606747; 27479988 JF - Environmental health perspectives AU - Cui, Yuxia AU - Balshaw, David M AU - Kwok, Richard K AU - Thompson, Claudia L AU - Collman, Gwen W AU - Birnbaum, Linda S AD - Exposure, Response, and Technology Branch, Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), U.S. Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA. Y1 - 2016/08/01/ PY - 2016 DA - 2016 Aug 01 SP - A137 EP - A140 VL - 124 IS - 8 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808606747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+Exposome%3A+Embracing+the+Complexity+for+Discovery+in+Environmental+Health.&rft.au=Cui%2C+Yuxia%3BBalshaw%2C+David+M%3BKwok%2C+Richard+K%3BThompson%2C+Claudia+L%3BCollman%2C+Gwen+W%3BBirnbaum%2C+Linda+S&rft.aulast=Cui&rft.aufirst=Yuxia&rft.date=2016-08-01&rft.volume=124&rft.issue=8&rft.spage=A137&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2FEHP412 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/EHP412 ER - TY - JOUR T1 - Characterizing "Adversity" of Pathology Findings in Nonclinical Toxicity Studies: Results from the 4th ESTP International Expert Workshop. AN - 1807899212; 27102650 AB - The identification of adverse health effects has a central role in the development and risk/safety assessment of chemical entities and pharmaceuticals. There is currently a need for better alignment regarding how nonclinical adversity is determined and characterized. The European Society of Toxicologic Pathology (ESTP) therefore coordinated a workshop to review available definitions of adversity, weigh determining and qualifying factors of adversity based on case examples, and recommend a practical approach to define and characterize adversity in toxicology reports, to serve as a valuable prerequisite for future organ- or lesion-specific workshops planned by the ESTP. © 2016 by The Author(s) 2016. JF - Toxicologic pathology AU - Palazzi, Xavier AU - Burkhardt, John E AU - Caplain, Henri AU - Dellarco, Vicki AU - Fant, Pierluigi AU - Foster, John R AU - Francke, Sabine AU - Germann, Paul AU - Gröters, Sibylle AU - Harada, Takanori AU - Harleman, Johannes AU - Inui, Kosei AU - Kaufmann, Wolfgang AU - Lenz, Barbara AU - Nagai, Hirofumi AU - Pohlmeyer-Esch, Gabriele AU - Schulte, Agnes AU - Skydsgaard, Mikala AU - Tomlinson, Lindsay AU - Wood, Charles E AU - Yoshida, Midori AD - Sanofi, Vitry-sur-Seine, France xavier.palazzi@sanofi.com. ; Pfizer Inc., Groton, CT, USA. ; Sanofi, Vitry-sur-Seine, France. ; Independent Consultant, Silver Spring, Maryland, USA. ; WIL Research, a Charles River Company, Lyon, France. ; Tox Path Science, Congleton, Cheshire, UK. ; U.S. FDA, College Park, Maryland, USA. ; AbbVie, Ludwigshafen, Germany. ; BASF, Ludwigshafen, Germany. ; Institute of Environmental Toxicology, Ibaraki, Japan. ; Fresenius Kabi, Bad Homburg, Germany. ; Ishihara Sangyo Kaisha, Ltd., Osaka, Japan. ; Merck, Darmstadt, Germany. ; Roche Pharmaceutical Research and Early Development, Basel, Switzerland. ; Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan. ; Kaleidis Consultancy, Saint-Louis, France. ; Federal Institute for Risk Assessment, Berlin, Germany. ; Novo Nordisk A/S, Måløv, Denmark. ; Office of Research and Development, U.S. EPA, Research Triangle Park, North Carolina, USA. ; Food Safety Commission, Cabinet Office, Tokyo, Japan. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 810 EP - 824 VL - 44 IS - 6 KW - Index Medicus KW - NOAEL KW - LOAEL KW - hazard identification KW - adversity KW - toxicologic pathology KW - adverse effect UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807899212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Characterizing+%22Adversity%22+of+Pathology+Findings+in+Nonclinical+Toxicity+Studies%3A+Results+from+the+4th+ESTP+International+Expert+Workshop.&rft.au=Palazzi%2C+Xavier%3BBurkhardt%2C+John+E%3BCaplain%2C+Henri%3BDellarco%2C+Vicki%3BFant%2C+Pierluigi%3BFoster%2C+John+R%3BFrancke%2C+Sabine%3BGermann%2C+Paul%3BGr%C3%B6ters%2C+Sibylle%3BHarada%2C+Takanori%3BHarleman%2C+Johannes%3BInui%2C+Kosei%3BKaufmann%2C+Wolfgang%3BLenz%2C+Barbara%3BNagai%2C+Hirofumi%3BPohlmeyer-Esch%2C+Gabriele%3BSchulte%2C+Agnes%3BSkydsgaard%2C+Mikala%3BTomlinson%2C+Lindsay%3BWood%2C+Charles+E%3BYoshida%2C+Midori&rft.aulast=Palazzi&rft.aufirst=Xavier&rft.date=2016-08-01&rft.volume=44&rft.issue=6&rft.spage=810&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623316642527 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623316642527 ER - TY - JOUR T1 - Consensus Report of the 2015 Weinman International Conference on Mesothelioma. AN - 1807081958; 27453164 AB - On November 9 and 10, 2015, the International Conference on Mesothelioma in Populations Exposed to Naturally Occurring Asbestiform Fibers was held at the University of Hawaii Cancer Center in Honolulu, Hawaii. The meeting was cosponsored by the International Association for the Study of Lung Cancer, and the agenda was designed with significant input from staff at the U.S. National Cancer Institute and National Institute of Environmental Health Sciences. A multidisciplinary group of participants presented updates reflecting a range of disciplinary perspectives, including mineralogy, geology, epidemiology, toxicology, biochemistry, molecular biology, genetics, public health, and clinical oncology. The group identified knowledge gaps that are barriers to preventing and treating malignant mesothelioma (MM) and the required next steps to address barriers. This manuscript reports the group's efforts and focus on strategies to limit risk to the population and reduce the incidence of MM. Four main topics were explored: genetic risk, environmental exposure, biomarkers, and clinical interventions. Genetics plays a critical role in MM when the disease occurs in carriers of germline BRCA1 associated protein 1 mutations. Moreover, it appears likely that, in addition to BRCA1 associated protein 1, other yet unknown genetic variants may also influence the individual risk for development of MM, especially after exposure to asbestos and related mineral fibers. MM is an almost entirely preventable malignancy as it is most often caused by exposure to commercial asbestos or mineral fibers with asbestos-like health effects, such as erionite. In the past in North America and in Europe, the most prominent source of exposure was related to occupation. Present regulations have reduced occupational exposure in these countries; however, some people continue to be exposed to previously installed asbestos in older construction and other settings. Moreover, an increasing number of people are being exposed in rural areas that contain noncommercial asbestos, erionite, and other mineral fibers in soil or rock (termed naturally occurring asbestos [NOA]) and are being developed. Public health authorities, scientists, residents, and other affected groups must work together in the areas where exposure to asbestos, including NOA, has been documented in the environment to mitigate or reduce this exposure. Although a blood biomarker validated to be effective for use in screening and identifying MM at an early stage in asbestos/NOA-exposed populations is not currently available, novel biomarkers presented at the meeting, such as high mobility group box 1 and fibulin-3, are promising. There was general agreement that current treatment for MM, which is based on surgery and standard chemotherapy, has a modest effect on the overall survival (OS), which remains dismal. Additionally, although much needed novel therapeutic approaches for MM are being developed and explored in clinical trials, there is a critical need to invest in prevention research, in which there is a great opportunity to reduce the incidence and mortality from MM. Copyright © 2016 International Association for the Study of Lung Cancer. All rights reserved. JF - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer AU - Carbone, Michele AU - Kanodia, Shreya AU - Chao, Ann AU - Miller, Aubrey AU - Wali, Anil AU - Weissman, David AU - Adjei, Alex AU - Baumann, Francine AU - Boffetta, Paolo AU - Buck, Brenda AU - de Perrot, Marc AU - Dogan, A Umran AU - Gavett, Steve AU - Gualtieri, Alessandro AU - Hassan, Raffit AU - Hesdorffer, Mary AU - Hirsch, Fred R AU - Larson, David AU - Mao, Weimin AU - Masten, Scott AU - Pass, Harvey I AU - Peto, Julian AU - Pira, Enrico AU - Steele, Ian AU - Tsao, Anne AU - Woodard, Gavitt Alida AU - Yang, Haining AU - Malik, Shakun AD - Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, Hawaii. Electronic address: mcarbone@cc.hawaii.edu. ; Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, Hawaii; Samuel Oschin Comprehensive Cancer Institute and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California. ; Center for Global Health, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. ; National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina. ; Center to Reduce Cancer Health Disparities, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. ; Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. ; Mayo Clinic, Rochester, Minnesota. ; ERIM, University of New Caledonia, Noumea, New Caledonia. ; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York. ; Department of Geoscience, University of Nevada Las Vegas, Las Vegas, Nevada. ; Princess Margaret Cancer Centre, University Health Network, Toronto, Canada. ; Chemical and Biochemical Engineering Department and Center for Global and Regional Environmental Research, University of Iowa, Iowa City, Iowa. ; Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. ; Chemical/Earth Sciences Department, University of Modena, Modena, Italy. ; Thoracic Oncology Branch, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland. ; Mesothelioma Applied Research Foundation, Alexandria, Virginia. ; University of Colorado Cancer Center, Denver, Colorado. ; Thoracic Oncology, University of Hawaii Cancer Center, Honolulu, Hawaii. ; Cancer Research Institute, Zhejiang Cancer Hospital and Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang, Hangzhou, People's Republic of China. ; National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina. ; Cardiothoracic Surgery, New York University Langone Medical Center, New York, New York. ; Cancer Research UK, London School of Hygiene and Tropical Medicine, London, United Kingdom. ; Department of Public Health and Pediatrics, University of Turin, Turin, Italy. ; Notre Dame Integrated Imaging Facility, Notre Dame University, Notre Dame, Indiana. ; Department of Thoracic and Head and Neck Medical Oncology, Division of Cancer Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, Texas. ; Thoracic Surgery, University of California at San Francisco, San Francisco, California. ; Cancer Therapy Evaluation Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 1246 EP - 1262 VL - 11 IS - 8 KW - Index Medicus KW - Genetics KW - Asbestos KW - Therapy KW - Mesothelioma KW - BAP1 KW - Biomarkers KW - Erionite UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807081958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.atitle=Consensus+Report+of+the+2015+Weinman+International+Conference+on+Mesothelioma.&rft.au=Carbone%2C+Michele%3BKanodia%2C+Shreya%3BChao%2C+Ann%3BMiller%2C+Aubrey%3BWali%2C+Anil%3BWeissman%2C+David%3BAdjei%2C+Alex%3BBaumann%2C+Francine%3BBoffetta%2C+Paolo%3BBuck%2C+Brenda%3Bde+Perrot%2C+Marc%3BDogan%2C+A+Umran%3BGavett%2C+Steve%3BGualtieri%2C+Alessandro%3BHassan%2C+Raffit%3BHesdorffer%2C+Mary%3BHirsch%2C+Fred+R%3BLarson%2C+David%3BMao%2C+Weimin%3BMasten%2C+Scott%3BPass%2C+Harvey+I%3BPeto%2C+Julian%3BPira%2C+Enrico%3BSteele%2C+Ian%3BTsao%2C+Anne%3BWoodard%2C+Gavitt+Alida%3BYang%2C+Haining%3BMalik%2C+Shakun&rft.aulast=Carbone&rft.aufirst=Michele&rft.date=2016-08-01&rft.volume=11&rft.issue=8&rft.spage=1246&rft.isbn=&rft.btitle=&rft.title=Journal+of+thoracic+oncology+%3A+official+publication+of+the+International+Association+for+the+Study+of+Lung+Cancer&rft.issn=1556-1380&rft_id=info:doi/10.1016%2Fj.jtho.2016.04.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jtho.2016.04.028 ER - TY - JOUR T1 - An Electrocorticography Grid with Conductive Nanoparticles in a Polymer Thick Film on an Organic Substrate Improves CT and MR Imaging. AN - 1805768420; 26844363 AB - Purpose To develop an electrocorticography (ECoG) grid by using deposition of conductive nanoparticles in a polymer thick film on an organic substrate (PTFOS) that induces minimal, if any, artifacts on computed tomographic (CT) and magnetic resonance (MR) images and is safe in terms of tissue reactivity and MR heating. Materials and Methods All procedures were approved by the Animal Care and Use Committee and complied with the Public Health Services Guide for the Care and Use of Animals. Electrical functioning of PTFOS for cortical recording and stimulation was tested in two mice. PTFOS disks were implanted in two mice; after 30 days, the tissues surrounding the implants were harvested, and tissue injury was studied by using immunostaining. Five neurosurgeons rated mechanical properties of PTFOS compared with conventional grids by using a three-level Likert scale. Temperature increases during 30 minutes of 3-T MR imaging were measured in a head phantom with no grid, a conventional grid, and a PTFOS grid. Two neuroradiologists rated artifacts on CT and MR images of a cadaveric head specimen with no grid, a conventional grid, and a PTFOS grid by using a four-level Likert scale, and the mean ratings were compared between grids. Results Oscillatory local field potentials were captured with cortical recordings. Cortical stimulations in motor cortex elicited muscle contractions. PTFOS implants caused no adverse tissue reaction. Mechanical properties were rated superior to conventional grids (χ(2) test, P < .05). The temperature increase during MR imaging for the three cases of no grid, PTFOS grid, and conventional grid was 3.84°C, 4.05°C, and 10.13°C, respectively. PTFOS induced no appreciable artifacts on CT and MR images, and PTFOS image quality was rated significantly higher than that with conventional grids (two-tailed t test, P < .05). Conclusion PTFOS grids may be an attractive alternative to conventional ECoG grids with regard to mechanical properties, 3-T MR heating profile, and CT and MR imaging artifacts. (©) RSNA, 2016 Online supplemental material is available for this article. JF - Radiology AU - Ahmadi, Emad AU - Katnani, Husam A AU - Daftari Besheli, Laleh AU - Gu, Qiang AU - Atefi, Reza AU - Villeneuve, Martin Y AU - Eskandar, Emad AU - Lev, Michael H AU - Golby, Alexandra J AU - Gupta, Rajiv AU - Bonmassar, Giorgio AD - From the Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology (E.A., R.A., M.Y.V., G.B.), Massachusetts General Hospital, Harvard Medical School, 75 Third Ave, Room 1.402, Charlestown, MA 02129; Advanced X-ray Imaging Sciences Center, Department of Radiology (E.A., L.D.B., M.H.L., R.G.), and Department of Neurosurgery (H.A.K., E.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Ark (Q.G.); and Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass (A.J.G.). Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 595 EP - 601 VL - 280 IS - 2 KW - Abridged Index Medicus KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805768420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=An+Electrocorticography+Grid+with+Conductive+Nanoparticles+in+a+Polymer+Thick+Film+on+an+Organic+Substrate+Improves+CT+and+MR+Imaging.&rft.au=Ahmadi%2C+Emad%3BKatnani%2C+Husam+A%3BDaftari+Besheli%2C+Laleh%3BGu%2C+Qiang%3BAtefi%2C+Reza%3BVilleneuve%2C+Martin+Y%3BEskandar%2C+Emad%3BLev%2C+Michael+H%3BGolby%2C+Alexandra+J%3BGupta%2C+Rajiv%3BBonmassar%2C+Giorgio&rft.aulast=Ahmadi&rft.aufirst=Emad&rft.date=2016-08-01&rft.volume=280&rft.issue=2&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=1527-1315&rft_id=info:doi/10.1148%2Fradiol.2016142529 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1148/radiol.2016142529 ER - TY - JOUR T1 - Effects of a Pilot Church-Based Intervention to Reduce HIV Stigma and Promote HIV Testing Among African Americans and Latinos AN - 1803278806 AB - HIV-related stigma and mistrust contribute to HIV disparities. Addressing stigma with faith partners may be effective, but few church-based stigma reduction interventions have been tested. We implemented a pilot intervention with 3 Latino and 2 African American churches (4 in matched pairs) in high HIV prevalence areas of Los Angeles County to reduce HIV stigma and mistrust and increase HIV testing. The intervention included HIV education and peer leader workshops, pastor-delivered sermons on HIV with imagined contact scenarios, and HIV testing events. We surveyed congregants at baseline and 6 month follow-up (n = 1235) and found statistically significant (p < 0.05) reductions in HIV stigma and mistrust in the Latino intervention churches but not in the African American intervention church nor overall across matched African American and Latino pairs. However, within matched pairs, intervention churches had much higher rates of HIV testing (p < 0.001). Stigma reduction and HIV testing may have synergistic effects in community settings. JF - AIDS and Behavior AU - Derose, Kathryn P AU - Griffin, Beth Ann AU - Kanouse, David E AU - Bogart, Laura M AU - Williams, Malcolm V AU - Haas, Ann C AU - Flórez, Karen R AU - Collins, Deborah Owens AU - Hawes-dawson, Jennifer AU - Mata, Michael A AU - Oden, Clyde W AU - Stucky, Brian D AD - RAND Corporation, PO Box 2138, Santa Monica, CA, USA ; RAND Corporation, Arlington, VA, USA ; RAND Corporation, PO Box 2138, Santa Monica, CA, USA; Division of General Pediatrics, Department of Medicine, Boston Children's Hospital, Boston, MA, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, USA ; RAND Corporation, Pittsburgh, PA, USA ; Long Beach Department of Health and Human Services, Long Beach, CA, USA ; Azusa Pacific Seminary, Azusa, CA, USA ; Bryant Temple African Methodist Episcopal Church, Los Angeles, CA, USA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 1692 EP - 1705 CY - New York PB - Springer Science & Business Media VL - 20 IS - 8 SN - 1090-7165 KW - Psychology KW - HIV stigma KW - HIV mistrust KW - African Americans KW - Latinos KW - Stigma reduction KW - Church-based interventions KW - Acquired Immune Deficiency Syndrome KW - Intervention KW - Black Americans KW - Stigma KW - Hispanic Americans KW - Racial Differences KW - Sermons KW - Los Angeles County California KW - 6126:acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803278806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Effects+of+a+Pilot+Church-Based+Intervention+to+Reduce+HIV+Stigma+and+Promote+HIV+Testing+Among+African+Americans+and+Latinos&rft.au=Derose%2C+Kathryn+P%3BGriffin%2C+Beth+Ann%3BKanouse%2C+David+E%3BBogart%2C+Laura+M%3BWilliams%2C+Malcolm+V%3BHaas%2C+Ann+C%3BFl%C3%B3rez%2C+Karen+R%3BCollins%2C+Deborah+Owens%3BHawes-dawson%2C+Jennifer%3BMata%2C+Michael+A%3BOden%2C+Clyde+W%3BStucky%2C+Brian+D&rft.aulast=Derose&rft.aufirst=Kathryn&rft.date=2016-08-01&rft.volume=20&rft.issue=8&rft.spage=1692&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-015-1280-y LA - English DB - Social Services Abstracts N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-10-25 N1 - SubjectsTermNotLitGenreText - Los Angeles County California DO - http://dx.doi.org/10.1007/s10461-015-1280-y ER - TY - JOUR T1 - MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes. AN - 1802472590; 27311985 AB - Cytochrome P450 2B6 (CYP2B6), mainly expressed in the liver and brain, is important for processing a number of widely used drugs. Variations in CYP2B6 expression are associated with decreased drug efficacy or adverse effects in some patients. Although CYP2B6 genetic variants are associated with its differential expression, epigenetic mechanisms affecting CYP2B6 gene regulation have not been established. Sequence analysis identified 29 domains in the CYP2B6 mRNA transcript that could be subject to regulation by microRNAs. Inverse correlations were found in human hepatocytes for the levels of the microRNAs hsa-miR-504-5p and hsa-miR-25-3p compared with CYP2B6 mRNA. Reporter gene assays showed that hsa-miR-25-3p suppresses CYP2B6 expression by targeting a specific sequence in the 3'-untranslated region of the mRNA transcript. Electrophoretic mobility shift assays confirmed that hsa-miR-25-3p forms stable complexes with its cognate mRNA sequence and that it recruits cellular factors, including Ago-4. Transfection of HepaRG cells with hsa-miR-25-3p mimics inhibited expression of the endogenous CYP2B6 gene and it also decreased rifampicin-dependent induction of CYP2B6 at the mRNA and protein levels. In summary, in silico and in vitro analyses show that hsa-miR-25-3p suppresses CYP2B6 expression in human liver cells via an epigenetic mechanism. Published by Elsevier Inc. JF - Biochemical pharmacology AU - Jin, Yaqiong AU - Yu, Dianke AU - Tolleson, William H AU - Knox, Bridgett AU - Wang, Yong AU - Chen, Si AU - Ren, Zhen AU - Deng, Helen AU - Guo, Yongli AU - Ning, Baitang AD - Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: dianke.yu@fda.hhs.gov. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Arkansas Department of Health, Little Rock, AR 72205, USA. ; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. Electronic address: guoyongli@bch.com.cn. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: baitang.ning@fda.hhs.gov. Y1 - 2016/08/01/ PY - 2016 DA - 2016 Aug 01 SP - 88 EP - 96 VL - 113 KW - Index Medicus KW - Pharmacogenomics KW - CYP2B6 KW - Drug metabolizing enzymes KW - hsa-miR-25-3p KW - Inter-individual variability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802472590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=MicroRNA+hsa-miR-25-3p+suppresses+the+expression+and+drug+induction+of+CYP2B6+in+human+hepatocytes.&rft.au=Jin%2C+Yaqiong%3BYu%2C+Dianke%3BTolleson%2C+William+H%3BKnox%2C+Bridgett%3BWang%2C+Yong%3BChen%2C+Si%3BRen%2C+Zhen%3BDeng%2C+Helen%3BGuo%2C+Yongli%3BNing%2C+Baitang&rft.aulast=Jin&rft.aufirst=Yaqiong&rft.date=2016-08-01&rft.volume=113&rft.issue=&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2016.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcp.2016.06.007 ER - TY - JOUR T1 - Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents. AN - 1801861554; 27234134 AB - Diet is an important variable in toxicology. There are mixed reports on the impact of soy components on energy utilization, fat deposition, and reproductive parameters. Three generations of CD-1 mice were fed irradiated natural ingredient diets with varying levels of soy (NIH-41, 5K96, or 5008/5001), purified irradiated AIN-93 diet, or the AIN-93 formulation modified with ethanol-washed soy protein concentrate (SPC) or SPC with isoflavones (SPC-IF). NIH-41 was the control for pairwise comparisons. Minimal differences were observed among natural ingredient diet groups. F0 males fed AIN-93, SPC, and SPC-IF diets had elevated glucose levels and lower insulin levels compared with the NIH-41 group. In both sexes of the F1 and F2 generations, the SPC and SPC-IF groups had lower body weight gains than the NIH-41 controls and the AIN-93 group had an increased percent body fat at postnatal day 21. AIN-93 F1 pups had higher baseline glucose than NIH-41 controls, but diet did not significantly affect breeding performance or responses to glucose or uterotrophic challenges. Reduced testes weight and sperm in the AIN-93 group may be related to low thiamine levels. Our observations underline the importance of careful selection, manufacturing procedures, and nutritional characterization of diets used in toxicological studies. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Camacho, Luísa AU - Lewis, Sherry M AU - Vanlandingham, Michelle M AU - Juliar, Beth E AU - Olson, Greg R AU - Patton, Ralph E AU - Gamboa da Costa, Gonçalo AU - Woodling, Kellie AU - Sepehr, Estatira AU - Bryant, Matthew S AU - Doerge, Daniel R AU - Basavarajappa, Mallikarjuna S AU - Felton, Robert P AU - Delclos, K Barry AD - Divisions of Biochemical Toxicology, Jefferson, AR 72079, USA. ; Office of Scientific Coordination, Jefferson, AR 72079, USA. ; Bioinformatics and Biostatistics, Jefferson, AR 72079, USA. ; National Center for Toxicological Research, and Toxicologic Pathology Associates, Jefferson, AR 72079, USA. ; Divisions of Biochemical Toxicology, Jefferson, AR 72079, USA. Electronic address: barry.delclos@fda.hhs.gov. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 39 EP - 56 VL - 94 KW - Index Medicus KW - Purified ingredient diet KW - Soy KW - Natural ingredient diet KW - Thiamine KW - Isoflavones KW - CD-1 mouse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1801861554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Comparison+of+endpoints+relevant+to+toxicity+assessments+in+3+generations+of+CD-1+mice+fed+irradiated+natural+and+purified+ingredient+diets+with+varying+soy+protein+and+isoflavone+contents.&rft.au=Camacho%2C+Lu%C3%ADsa%3BLewis%2C+Sherry+M%3BVanlandingham%2C+Michelle+M%3BJuliar%2C+Beth+E%3BOlson%2C+Greg+R%3BPatton%2C+Ralph+E%3BGamboa+da+Costa%2C+Gon%C3%A7alo%3BWoodling%2C+Kellie%3BSepehr%2C+Estatira%3BBryant%2C+Matthew+S%3BDoerge%2C+Daniel+R%3BBasavarajappa%2C+Mallikarjuna+S%3BFelton%2C+Robert+P%3BDelclos%2C+K+Barry&rft.aulast=Camacho&rft.aufirst=Lu%C3%ADsa&rft.date=2016-08-01&rft.volume=94&rft.issue=&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.05.014 ER - TY - JOUR T1 - Valuing Reductions in Fatal Illness Risks: Implications of Recent Research AN - 1801377468 AB - The value of mortality risk reductions, conventionally expressed as the value per statistical life, is an important determinant of the net benefits of many government policies. US regulators currently rely primarily on studies of fatal injuries, raising questions about whether different values might be appropriate for risks associated with fatal illnesses. Our review suggests that, despite the substantial expansion of the research base in recent years, few US studies of illness-related risks meet criteria for quality, and those that do yield similar values to studies of injury-related risks. Given this result, combining the findings of these few studies with the findings of the more robust literature on injury-related risks appears to provide a reasonable range of estimates for application in regulatory analysis. Our review yields estimates ranging from about $4.2 million to $13.7 million with a mid-point of $9.0 million (2013 dollars). Although the studies we identify differ from those that underlie the values currently used by Federal agencies, the resulting estimates are remarkably similar, suggesting that there is substantial consensus emerging on the values applicable to the general US population. Copyright © 2015 John Wiley & Sons, Ltd. JF - Health Economics AU - Robinson, Lisa A AU - Hammitt, James K AD - Harvard University (Center for Risk Analysis), Boston, MA, USA ; Harvard University (Center for Risk Analysis), Boston, MA, USA; Toulouse School of Economics (LERNA), Toulouse, France; U.S. Department of Health and Human Services, Washington, D.C., USA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 1039 EP - 1052 CY - York PB - Wiley Subscription Services, Inc. VL - 25 IS - 8 SN - 1057-9230 KW - Business And Economics--Economic Situation And Conditions KW - Sickness KW - Mortality KW - Federal agencies KW - Values KW - Injuries KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1801377468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Valuing+Reductions+in+Fatal+Illness+Risks%3A+Implications+of+Recent+Research&rft.au=Robinson%2C+Lisa+A%3BHammitt%2C+James+K&rft.aulast=Robinson&rft.aufirst=Lisa&rft.date=2016-08-01&rft.volume=25&rft.issue=8&rft.spage=1039&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.3214 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © 2016 John Wiley & Sons, Ltd. N1 - Last updated - 2016-09-09 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1002/hec.3214 ER - TY - JOUR T1 - Effectiveness of an Adaptation of the Project Connect Health Systems Intervention: Youth and Clinic-Level Findings AN - 1801372472 AB - BACKGROUND The Project Connect Health Systems Intervention (Project Connect) uses a systematic process of collecting community and healthcare infrastructure information to craft a referral guide highlighting local healthcare providers who provide high quality sexual and reproductive healthcare. Previous self-report data on healthcare usage indicated Project Connect was successful with sexually experienced female youth, where it increased rates of human immunodeficiency virus (HIV) and sexually transmitted disease (STD) testing and receipt of contraception. This adaption of Project Connect examined its effectiveness in a new context and via collection of clinic encounter-level data. METHODS Project Connect was implemented in 3 high schools. (only 2 schools remained open throughout the entire project period). Participant recruitment and data collection occurred in 5 of 8 participating health clinics. Students completed Youth Surveys (N=608) and a Clinic Survey (paired with medical data abstraction in 2 clinics [N=305]). RESULTS Students were more likely than nonstudents to report having reached a clinic via Project Connect. Nearly 40% of students attended a Project Connect school, with 32.7% using Project Connect to reach the clinic. Students were most likely to have been referred by a school nurse or coach. CONCLUSIONS Project Connect is a low-cost, sustainable structural intervention with multiple applications within schools, either as a standalone intervention or in combination with ongoing efforts. JF - The Journal of School Health AU - Loosier, Penny S AU - Doll, Shelli AU - Lepar, Danielle AU - Ward, Kristin AU - Gamble, Ginger AU - Dittus, Patricia J AD - Centers for Disease Control and Prevention, GA ; HIV Care and Prevention Section, Michigan Department of Health and Human Services, Lansing, MI ; Center for Data Management and Translational Research, Michigan Public Health Institute, Okemos, MI ; Centers for Disease Control and Prevention, 1600 Clifton Road, MS-E44, Atlanta, GA Y1 - 2016/08// PY - 2016 DA - Aug 2016 SP - 595 EP - 603 CY - Kent PB - Wiley Subscription Services, Inc. VL - 86 IS - 8 SN - 0022-4391 KW - Physical Fitness And Hygiene KW - Students KW - Schools KW - Sexually transmitted diseases--STD KW - Human immunodeficiency virus--HIV KW - Clinics KW - Immune disorders KW - Contraception KW - High schools KW - Recruitment KW - Surveys KW - Young people KW - Sexually transmitted diseases KW - Interventions KW - HIV KW - Selfreport KW - Data collection KW - Infrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1801372472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+School+Health&rft.atitle=Effectiveness+of+an+Adaptation+of+the+Project+Connect+Health+Systems+Intervention%3A+Youth+and+Clinic-Level+Findings&rft.au=Loosier%2C+Penny+S%3BDoll%2C+Shelli%3BLepar%2C+Danielle%3BWard%2C+Kristin%3BGamble%2C+Ginger%3BDittus%2C+Patricia+J&rft.aulast=Loosier&rft.aufirst=Penny&rft.date=2016-08-01&rft.volume=86&rft.issue=8&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fjosh.12414 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © 2016, American School Health Association N1 - Last updated - 2016-08-16 DO - http://dx.doi.org/10.1111/josh.12414 ER - TY - JOUR T1 - Comparison of cell counting methods in rodent pulmonary toxicity studies: automated and manual protocols and considerations for experimental design. AN - 1797866110; 27251196 AB - Pulmonary toxicity studies often use bronchoalveolar lavage (BAL) to investigate potential adverse lung responses to a particulate exposure. The BAL cellular fraction is counted, using automated (i.e. Coulter Counter®), flow cytometry or manual (i.e. hemocytometer) methods, to determine inflammatory cell influx. The goal of the study was to compare the different counting methods to determine which is optimal for examining BAL cell influx after exposure by inhalation or intratracheal instillation (ITI) to different particles with varying inherent pulmonary toxicities in both rat and mouse models. General findings indicate that total BAL cell counts using the automated and manual methods tended to agree after inhalation or ITI exposure to particle samples that are relatively nontoxic or at later time points after exposure to a pneumotoxic particle when the response resolves. However, when the initial lung inflammation and cytotoxicity was high after exposure to a pneumotoxic particle, significant differences were observed when comparing cell counts from the automated, flow cytometry and manual methods. When using total BAL cell count for differential calculations from the automated method, depending on the cell diameter size range cutoff, the data suggest that the number of lung polymorphonuclear leukocytes (PMN) varies. Importantly, the automated counts, regardless of the size cutoff, still indicated a greater number of total lung PMN when compared with the manual method, which agreed more closely with flow cytometry. The results suggest that either the manual method or flow cytometry would be better suited for BAL studies where cytotoxicity is an unknown variable. JF - Inhalation toxicology AU - Zeidler-Erdely, Patti C AU - Antonini, James M AU - Meighan, Terence G AU - Young, Shih-Houng AU - Eye, Tracy J AU - Hammer, Mary Ann AU - Erdely, Aaron AD - a Health Effects Laboratory Division, National Institute for Occupational Safety and Health , Morgantown , WV , USA and. ; b Army Public Health Center (Provisional) , Aberdeen Proving Ground , MD , USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 410 EP - 420 VL - 28 IS - 9 KW - Index Medicus KW - carbon nanotubes KW - hemocytometer KW - metals KW - cytotoxicity KW - flow cytometry KW - welding fume KW - Bronchoalveolar lavage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797866110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Comparison+of+cell+counting+methods+in+rodent+pulmonary+toxicity+studies%3A+automated+and+manual+protocols+and+considerations+for+experimental+design.&rft.au=Zeidler-Erdely%2C+Patti+C%3BAntonini%2C+James+M%3BMeighan%2C+Terence+G%3BYoung%2C+Shih-Houng%3BEye%2C+Tracy+J%3BHammer%2C+Mary+Ann%3BErdely%2C+Aaron&rft.aulast=Zeidler-Erdely&rft.aufirst=Patti&rft.date=2016-08-01&rft.volume=28&rft.issue=9&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.1080%2F08958378.2016.1189985 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/08958378.2016.1189985 ER - TY - JOUR T1 - An FDA oncology view of juvenile animal studies in support of initial pediatric trials for anticancer drugs. AN - 1794469494; 26952647 JF - Regulatory toxicology and pharmacology : RTP AU - Leighton, John K AU - Saber, Haleh AU - Reaman, Gregory AU - Pazdur, Richard AD - US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Hematology and Oncology Products, 10903 New Hampshire Ave, Silver Spring, MD 20903, United States. Electronic address: john.leighton@fda.hhs.gov. ; US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Hematology and Oncology Products, 10903 New Hampshire Ave, Silver Spring, MD 20903, United States. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 142 EP - 143 VL - 79 KW - Index Medicus KW - Juvenile animal studies KW - First in pediatric trials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1794469494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=An+FDA+oncology+view+of+juvenile+animal+studies+in+support+of+initial+pediatric+trials+for+anticancer+drugs.&rft.au=Leighton%2C+John+K%3BSaber%2C+Haleh%3BReaman%2C+Gregory%3BPazdur%2C+Richard&rft.aulast=Leighton&rft.aufirst=John&rft.date=2016-08-01&rft.volume=79&rft.issue=&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.03.001 ER - TY - JOUR T1 - Relevance of nanocomposite packaging on the stability of vacuum-packed dry cured ham. AN - 1789044785; 26998947 AB - In this study effects of a novel high barrier multilayer polyamide film containing dispersed nanoclays (PAN) on the stability of vacuum packed dry-cured ham were investigated during 90days refrigerated storage in comparison with non-modified multilayer polyamide (PA) and a commercial high barrier film. Characteristic bands of the mineral in FT-IR spectra confirmed the presence of nanoclays in PAN, enhancing oxygen transmission barrier properties and UV protection. Packaging in PAN films did not originate significant changes on colour or lipid oxidation during prolonged storage of vacuum-packed dry-cured ham. Larger oxygen transmission rates in PA films caused changes in CIE b* during refrigerated storage. Ham quality was not affected by light exposition during 90days and only curing had a significant benefit on colour and TBARS, being cured samples more stable during storage in all the packages used. Packaging of dry-cured ham in PAN was equivalent to commercial high barrier films. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Meat science AU - Lloret, Elsa AU - Fernandez, Avelina AU - Trbojevich, Raul AU - Arnau, Jacint AU - Picouet, Pierre A AD - Departament de Tecnologia dels Aliments, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Monells, Girona, Spain. ; Instituto de Física Corpuscular (CSIC-UVEG), Parc Científic, Paterna, Valencia, Spain. ; Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, United States. ; Departament de Tecnologia dels Aliments, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Monells, Girona, Spain. Electronic address: pierre.picouet@irta.cat. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 8 EP - 14 VL - 118 KW - Index Medicus KW - Meat KW - TBARS KW - Skin KW - Clay KW - Ham KW - Vacuum KW - Nanocomposite KW - Polyamide UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789044785?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Meat+science&rft.atitle=Relevance+of+nanocomposite+packaging+on+the+stability+of+vacuum-packed+dry+cured+ham.&rft.au=Lloret%2C+Elsa%3BFernandez%2C+Avelina%3BTrbojevich%2C+Raul%3BArnau%2C+Jacint%3BPicouet%2C+Pierre+A&rft.aulast=Lloret&rft.aufirst=Elsa&rft.date=2016-08-01&rft.volume=118&rft.issue=&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Meat+science&rft.issn=1873-4138&rft_id=info:doi/10.1016%2Fj.meatsci.2016.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.meatsci.2016.03.007 ER - TY - JOUR T1 - Suppression of basal and carbon nanotube-induced oxidative stress, inflammation and fibrosis in mouse lungs by Nrf2. AN - 1789041053; 26592091 AB - The lungs are susceptible to oxidative damage by inhaled pathogenic agents, including multi-walled carbon nanotubes (MWCNT). The nuclear factor erythroid 2-related factor 2 (Nrf2) has been implicated in regulating the body's defense against oxidative stress. Here, we analyzed the function of Nrf2 in the lungs. Under a basal condition, Nrf2 knockout (KO) mice showed apparent pulmonary infiltration of granulocytes, macrophages and B and T lymphocytes, and elevated deposition of collagen fibers. Exposure to MWCNT (XNRI MWNT-7, Mitsui, Tokyo, Japan) by pharyngeal aspiration elicited rapid inflammatory and fibrotic responses in a dose (0, 5, 20 and 40 μg) and time (1, 3, 7 and 14 d)-dependent manner. The responses reached peak levels on day 7 post-exposure to 40 μg MWCNT, evidenced by massive inflammatory infiltration and formation of inflammatory and fibrotic foci, which were more evident in Nrf2 KO than wild-type (WT) lungs. At the molecular level, Nrf2 protein was detected at a low level under a basal condition, and was dramatically increased by MWCNT in WT, but not Nrf2 KO, lungs. Activation of Nrf2 was inversely correlated with induced expression of fibrosis marker genes and profibrotic cytokines. Furthermore, the levels of ROS and oxidative stress were remarkably higher in Nrf2 KO than WT lungs under a physiological condition, and were dramatically increased by MWCNT, with the increase significantly more striking in KO lungs. The findings reveal that Nrf2 plays an important role in suppressing the basal and MWCNT-induced oxidant production, inflammation and fibrosis in the lungs, thereby protecting against MWCNT lung toxicity. JF - Nanotoxicology AU - Dong, Jie AU - Ma, Qiang AD - a Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Morgantown , WV , USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 699 EP - 709 VL - 10 IS - 6 KW - Index Medicus KW - multi-walled carbon nanotubes KW - lung inflammation KW - nanotoxicity KW - Lung fibrosis KW - oxidative stress KW - nuclear factor erythroid 2-related factor 2 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789041053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Suppression+of+basal+and+carbon+nanotube-induced+oxidative+stress%2C+inflammation+and+fibrosis+in+mouse+lungs+by+Nrf2.&rft.au=Dong%2C+Jie%3BMa%2C+Qiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2016-08-01&rft.volume=10&rft.issue=6&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2015.1110758 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/17435390.2015.1110758 ER - TY - JOUR T1 - Distribution and accumulation of 10 nm silver nanoparticles in maternal tissues and visceral yolk sac of pregnant mice, and a potential effect on embryo growth. AN - 1789041049; 26593872 AB - We examined the distribution of silver in pregnant mice and embryos/fetuses following intravenous injections of 10 nm silver nanoparticles (AgNPs) or soluble silver nitrate (AgNO3) at dose levels of 0 (citrate buffer control) or 66 µg Ag/mouse to pregnant mice on gestation days (GDs) 7, 8 and 9. Selected maternal tissues and all embryos/fetuses from control, AgNP- and AgNO3-treated groups on GD10 and control and AgNP-treated groups on GD16 were processed for the measurement of silver concentrations, intracellular AgNP localization, histopathology and gross examination of tissue morphology. Inductively-coupled plasma mass spectrometry revealed silver in all examined tissues following either AgNP or AgNO3 treatment, with highest concentrations of silver in maternal liver, spleen and visceral yolk sac (VYS), and lowest concentrations in embryos/fetuses. For VYS, mean silver concentration following AgNO3 treatment (4.87 ng Ag/mg tissue) was approximately two-fold that following AgNP treatment (2.31 ng Ag/mg tissue); for all other tissues examined, mean silver concentrations following either AgNP or AgNO3 treatment were not significantly different from each other (e.g. 2.57 or 2.84 ng Ag/mg tissue in maternal liver and 1.61 or 2.50 ng Ag/mg tissue in maternal spleen following AgNP or AgNO3 treatment, respectively). Hyperspectral imaging revealed AgNP aggregates in maternal liver, kidney, spleen and VYS from AgNP-treated mice, but not AgNO3-treated mice. Additionally, one or more embryos collected on GD10 from eight of ten AgNP-treated mice appeared small for their age (i.e. Theiler stage 13 [GD8.5] or younger). In the control group (N = 11), this effect was seen in embryos from only one mouse. In conclusion, intravenous injection of 10 nm AgNPs to pregnant mice resulted in notable silver accumulation in maternal liver, spleen and VYS, and may have affected embryonic growth. Silver accumulation in embryos/fetuses was negligible. JF - Nanotoxicology AU - Austin, Carlye A AU - Hinkley, Georgia K AU - Mishra, Anurag R AU - Zhang, Qin AU - Umbreit, Thomas H AU - Betz, Martha W AU - E Wildt, Bridget AU - Casey, Brendan J AU - Francke-Carroll, Sabine AU - Hussain, Saber M AU - Roberts, Stephen M AU - Brown, Ken M AU - Goering, Peter L AD - a Department of Biological Sciences , George Washington University , Washington , DC , USA . ; b Center for Environmental and Human Toxicology, University of Florida , Gainesville , FL , USA . ; c Center for Devices and Radiological Health, US Food and Drug Administration , Silver Spring , MD , USA . ; d Center for Food Safety and Nutrition, US Food and Drug Administration , College Park , MD , USA , and. ; e Air Force Research Laboratory, Wright-Patterson Air Force Base , Dayton , OH , USA. Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 654 EP - 661 VL - 10 IS - 6 KW - Index Medicus KW - fetus KW - nanosilver KW - toxicity KW - pregnancy KW - Development KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789041049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Distribution+and+accumulation+of+10%E2%80%89nm+silver+nanoparticles+in+maternal+tissues+and+visceral+yolk+sac+of+pregnant+mice%2C+and+a+potential+effect+on+embryo+growth.&rft.au=Austin%2C+Carlye+A%3BHinkley%2C+Georgia+K%3BMishra%2C+Anurag+R%3BZhang%2C+Qin%3BUmbreit%2C+Thomas+H%3BBetz%2C+Martha+W%3BE+Wildt%2C+Bridget%3BCasey%2C+Brendan+J%3BFrancke-Carroll%2C+Sabine%3BHussain%2C+Saber+M%3BRoberts%2C+Stephen+M%3BBrown%2C+Ken+M%3BGoering%2C+Peter+L&rft.aulast=Austin&rft.aufirst=Carlye&rft.date=2016-08-01&rft.volume=10&rft.issue=6&rft.spage=654&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2015.1107143 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/17435390.2015.1107143 ER - TY - JOUR T1 - Evaluation of corn oil as an additive in the pre-enrichment step to increase recovery of Salmonella enterica from oregano AN - 1785241199; PQ0002919485 AB - Phenolic compounds associated with essential oils of spices and herbs possess a variety of antioxidant and antimicrobial properties that interfere with Salmonella detection from fresh and dried products. Finding a compound to neutralize the effect of these antimicrobial compounds, while allowing Salmonella growth during pre-enrichment, is a crucial step in both traditional pathogen isolation and molecular detection from these foods. This study evaluated the effectiveness of corn oil as a component of the pre-enrichment broth to counteract antimicrobial compounds properties and increase the recovery of Salmonella from spices. Oregano samples artificially contaminated with Salmonella enterica were pre-enriched in modified Buffered Peptone Water (mBPW) supplemented with and without 2% (vol/vol) corn oil respectively. Samples were incubated overnight at 37 degree C. The results showed that recovery of Salmonella from oregano samples was increased by greater than or equal to 50% when pre-enriched with corn oil. Serovars were confirmed using a PCR serotyping method. In addition, shot-gun metagenomics analyses demonstrated bacterial diversity and the effect of corn oil on the relative prevalence of Salmonella in the oregano samples. Modifying pre-enrichment broths with corn oil improved the detection and isolation of Salmonella from oregano, and may provide an alternative method for pathogen detection in dried food matrices such as spices. JF - Food Microbiology AU - Jean-Gilles Beaubrun, Junia AU - Flamer, Marie-Laure AU - Addy, Nicole AU - Ewing, Laura AU - Gopinath, Gopal AU - Jarvis, Karen AU - Grim, Chris AU - Hanes, Darcy E AD - U.S. Food and Drug Administration, Laurel, MD, 20708, USA Y1 - 2016/08// PY - 2016 DA - August 2016 SP - 195 EP - 203 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 57 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salmonella spp. KW - Montevideo KW - Oregano KW - Additives KW - Corn oil KW - Molecular serotyping KW - Shot-gun metagenomics KW - Antioxidants KW - Food KW - Spices KW - Serotyping KW - Origanum KW - Pathogens KW - Antimicrobial agents KW - Salmonella enterica KW - peptone KW - Corn KW - Essential oils KW - phenolic compounds KW - Polymerase chain reaction KW - Peptones KW - Herbs KW - J 02320:Cell Biology KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785241199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Evaluation+of+corn+oil+as+an+additive+in+the+pre-enrichment+step+to+increase+recovery+of+Salmonella+enterica+from+oregano&rft.au=Jean-Gilles+Beaubrun%2C+Junia%3BFlamer%2C+Marie-Laure%3BAddy%2C+Nicole%3BEwing%2C+Laura%3BGopinath%2C+Gopal%3BJarvis%2C+Karen%3BGrim%2C+Chris%3BHanes%2C+Darcy+E&rft.aulast=Jean-Gilles+Beaubrun&rft.aufirst=Junia&rft.date=2016-08-01&rft.volume=57&rft.issue=&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2016.03.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Antioxidants; peptone; Food; Spices; Polymerase chain reaction; phenolic compounds; Essential oils; Serotyping; Pathogens; Herbs; Antimicrobial agents; Corn; Peptones; Additives; Salmonella enterica; Origanum DO - http://dx.doi.org/10.1016/j.fm.2016.03.005 ER - TY - JOUR T1 - Temperature-mediated recombinant anthrax protective antigen aggregate development: Implications for toxin formation and immunogenicity. AN - 1806436996; 27364097 AB - Anthrax vaccines containing recombinant PA (rPA) as the only antigen face a stability issue: rPA forms aggregates in solution after exposure to temperatures ⩾40°C, thus losing its ability to form lethal toxin (LeTx) with Lethal Factor. To study rPA aggregation's impact on immune response, we subjected rPA to several time and temperature combinations. rPA treated at 50°C for 30min formed high mass aggregates when analyzed by gel electrophoresis and failed to form LeTx as measured by a macrophage lysis assay (MLA). Aggregated rPA-formed LeTx was about 30 times less active than LeTx containing native rPA. Mice immunized with heat-treated rPA combined with Al(OH)3 developed antibody titers about 49 times lower than mice immunized with native rPA, as measured by a Toxicity Neutralization Assay (TNA). Enzyme Linked Immunosorbent Assay (ELISA) of the same immune sera showed anti-rPA titers only 2-7 times lower than titers elicited by native rPA. Thus, rPA's ability to form LeTx correlates with its production of neutralizing antibodies, and aggregation significantly impairs the protein's antibody response. However, while these findings suggest MLA has some value as an in-process quality test for rPA in new anthrax vaccines, they also confirm the superiority of TNA for use in vaccine potency. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Vaccine AU - Amador-Molina, Juan C AU - Valerdi-Madrigal, Esther D AU - Domínguez-Castillo, Rocío I AU - Sirota, Lev A AU - Arciniega, Juan L AD - Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States. Electronic address: jc.amador@itesm.mx. ; Center for Biologics Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States. Y1 - 2016/07/29/ PY - 2016 DA - 2016 Jul 29 SP - 4188 EP - 4195 VL - 34 IS - 35 KW - Index Medicus KW - Vaccine KW - Anthrax KW - Aggregation KW - Stability KW - Protective antigen UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1806436996?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Temperature-mediated+recombinant+anthrax+protective+antigen+aggregate+development%3A+Implications+for+toxin+formation+and+immunogenicity.&rft.au=Amador-Molina%2C+Juan+C%3BValerdi-Madrigal%2C+Esther+D%3BDom%C3%ADnguez-Castillo%2C+Roc%C3%ADo+I%3BSirota%2C+Lev+A%3BArciniega%2C+Juan+L&rft.aulast=Amador-Molina&rft.aufirst=Juan&rft.date=2016-07-29&rft.volume=34&rft.issue=35&rft.spage=4188&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=1873-2518&rft_id=info:doi/10.1016%2Fj.vaccine.2016.06.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.vaccine.2016.06.057 ER - TY - JOUR T1 - Size and dose dependent effects of silver nanoparticle exposure on intestinal permeability in an in vitro model of the human gut epithelium. AN - 1807899135; 27465730 AB - The antimicrobial activity of silver nanoparticles (AgNP) has led to interest in their use in consumer products such as food contact materials, utensils, and storage containers. Incorporation of these materials into items intended for food processing and storage suggests that consumer use of these products could result in gastrointestinal exposure to AgNP, should the nanoparticles migrate from the product. The health impact of AgNP exposure is unknown, especially effects related to intestinal epithelial permeability and barrier function. This study examined the effects of AgNP exposure of different sizes (10, 20, 75 and 110 nm) and doses (20 and 100 µg/mL) on the permeability of T84 human colonic epithelial cells, which serve as an in vitro model of the human gut epithelium. Results showed that effects of AgNP on the T84 epithelial cells were size- and dose-dependent, with the 10 nm AgNP causing the most significant changes. Changes in permeability of the epithelial cell monolayer, as measured by transepithelial electrical resistance, after exposure to 10 nm AgNP were most dramatic at the highest dose (100 µg/mL), but also observed at the lower dose (20 µg/mL). AgNP could be visualized inside cells using transmission electron microscopy and silver was detected in basal wells using inductively coupled plasma-mass spectrometry. Exposure to AgNP significantly affected the expression of genes involved in anchoring tight junctions, cellular proliferation and signaling, endocytosis, and cell-cell adhesion, with the 10 nm AgNP having the greatest effect. The results of this study show that small-size AgNP have significant effects on intestinal permeability in an in vitro model of the human gastrointestinal epithelium. Such effects have the potential to compromise the integrity of the intestinal epithelium and this disruption of barrier function could have health consequences for the gastrointestinal tract. JF - Journal of nanobiotechnology AU - Williams, Katherine M AU - Gokulan, Kuppan AU - Cerniglia, Carl E AU - Khare, Sangeeta AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR, 72079, USA. ; Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd, Jefferson, AR, 72079, USA. sangeeta.khare@fda.hhs.gov. Y1 - 2016/07/28/ PY - 2016 DA - 2016 Jul 28 SP - 62 VL - 14 IS - 1 KW - Index Medicus KW - Intestinal permeability KW - Silver nanoparticles KW - Barrier function KW - Cell junctions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807899135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+nanobiotechnology&rft.atitle=Size+and+dose+dependent+effects+of+silver+nanoparticle+exposure+on+intestinal+permeability+in+an+in+vitro+model+of+the+human+gut+epithelium.&rft.au=Williams%2C+Katherine+M%3BGokulan%2C+Kuppan%3BCerniglia%2C+Carl+E%3BKhare%2C+Sangeeta&rft.aulast=Williams&rft.aufirst=Katherine&rft.date=2016-07-28&rft.volume=14&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Journal+of+nanobiotechnology&rft.issn=1477-3155&rft_id=info:doi/10.1186%2Fs12951-016-0214-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12951-016-0214-9 ER - TY - JOUR T1 - Subchronic Immunotoxicity Assessment of Genetically Modified Virus-Resistant Papaya in Rats. AN - 1807534507; 27396727 AB - Papaya is an important fruit that provides a variety of vitamins with nutritional value and also holds some pharmacological properties, including immunomodulation. Genetically modified (GM) papaya plants resistant to Papaya ringspot virus (PRSV) infection have been generated by cloning the coat protein gene of the PRSV which can be used as a valuable strategy to fight PRSV infection and to increase papaya production. In order to assess the safety of GM papaya as a food, this subchronic study was conducted to assess the immunomodulatory responses of the GM papaya line 823-2210, when compared with its parent plant of non-GM papaya, Tainung-2 (TN-2), in Sprague-Dawley (SD) rats. Both non-GM and GM 823-2210 papaya fruits at low (1 g/kg bw) and high (2 g/kg bw) dosages were administered via daily oral gavage to male and female rats consecutively for 90 days. Immunophenotyping, mitogen-induced splenic cell proliferation, antigen-specific antibody response, and histopathology of the spleen and thymus were evaluated at the end of the experiment. Results of immunotoxicity assays revealed no consistent difference between rats fed for 90 days with GM 823-2210 papaya fruits, as opposed to those fed non-GM TN-2 papaya fruits, suggesting that with regard to immunomodulatory responses, GM 823-2210 papaya fruits maintain substantial equivalence to fruits of their non-GM TN-2 parent. JF - Journal of agricultural and food chemistry AU - Lin, Hsin-Tang AU - Lee, Wei-Cheng AU - Tsai, Yi-Ting AU - Wu, Jhaol-Huei AU - Yen, Gow-Chin AU - Yeh, Shyi-Dong AU - Cheng, Ying-Huey AU - Chang, Shih-Chieh AU - Liao, Jiunn-Wang AD - Food and Drug Administration, Ministry of Health and Welfare , Taipei City115, Taiwan, Republic of China. ; Graduate Institute of Veterinary Pathobiology, National Chung Hsing University , Taichung 402, Taiwan, Republic of China. ; Department of Food Science and Biotechnology, National Chung Hsing University , Taichung 402, Taiwan, Republic of China. ; Department of Plant Pathology, National Chung Hsing University , Taichung 402, Taiwan, Republic of China. ; National Plant Genetic Resources Center, Taiwan Agricultural Research Institute , Taichung 413, Taiwan, Republic of China. ; Department of Veterinary Medicine, National Chung Hsing University , Taichung 402, Taiwan, Republic of China. Y1 - 2016/07/27/ PY - 2016 DA - 2016 Jul 27 SP - 5935 EP - 5940 VL - 64 IS - 29 KW - Index Medicus KW - subchronic KW - PRSV-GM papaya fruit KW - immunotoxicity KW - rats UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1807534507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Subchronic+Immunotoxicity+Assessment+of+Genetically+Modified+Virus-Resistant+Papaya+in+Rats.&rft.au=Lin%2C+Hsin-Tang%3BLee%2C+Wei-Cheng%3BTsai%2C+Yi-Ting%3BWu%2C+Jhaol-Huei%3BYen%2C+Gow-Chin%3BYeh%2C+Shyi-Dong%3BCheng%2C+Ying-Huey%3BChang%2C+Shih-Chieh%3BLiao%2C+Jiunn-Wang&rft.aulast=Lin&rft.aufirst=Hsin-Tang&rft.date=2016-07-27&rft.volume=64&rft.issue=29&rft.spage=5935&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Facs.jafc.6b02242 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.jafc.6b02242 ER - TY - JOUR T1 - Active tuberculosis case-finding among drug users and homeless persons: after the outbreak AN - 1808692327; PQ0003376270 AB - Tuberculosis (TB) control in high-risk settings and populations is a fascinating challenge, as it also is in the context of the World Health Organization (WHO) End TB strategy [1]; and it is frequently reported in medical journals. We previously described how an outbreak was built up among illicit drug users and homeless persons in Rotterdam, the Netherlands, and successfully controlled by a systematic targeted TB active case-finding programme, using a mobile digital X-ray unit (MDXU) [2, 3]. On the contrast, programmatic implications after an outbreak are rarely reported. This study evaluates the intervention among these urban risk groups by describing trends of TB disease, recent transmission, active case finding and treatment outcome, and by comparing efficiency and yield of screening during outbreak management (May 2002-2005) with post-outbreak screening (2006-2014). JF - European Respiratory Journal AU - van Hest, Rob AU - de Vries, Gerard AD - Municipal Public Health Service Groningen, Groningen, The Netherlands, nah.vanhest@rotterdam.nl Y1 - 2016/07/21/ PY - 2016 DA - 2016 Jul 21 SP - 269 EP - 271 PB - W.S. Maney & Son Ltd., Hudson Road Leeds LS9 7DL United Kingdom VL - 48 IS - 1 SN - 0903-1936, 0903-1936 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mycobacterium KW - Ionizing radiation KW - Risk groups KW - Tuberculosis KW - Drug abuse KW - Disease transmission KW - J 02310:Genetics & Taxonomy KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808692327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Respiratory+Journal&rft.atitle=Active+tuberculosis+case-finding+among+drug+users+and+homeless+persons%3A+after+the+outbreak&rft.au=van+Hest%2C+Rob%3Bde+Vries%2C+Gerard&rft.aulast=van+Hest&rft.aufirst=Rob&rft.date=2016-07-21&rft.volume=48&rft.issue=1&rft.spage=269&rft.isbn=&rft.btitle=&rft.title=European+Respiratory+Journal&rft.issn=09031936&rft_id=info:doi/10.1183%2F13993003.00284-2016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Ionizing radiation; Risk groups; Tuberculosis; Drug abuse; Disease transmission; Mycobacterium DO - http://dx.doi.org/10.1183/13993003.00284-2016 ER - TY - JOUR T1 - In Chemico Evaluation of Tea Tree Essential Oils as Skin Sensitizers: Impact of the Chemical Composition on Aging and Generation of Reactive Species. AN - 1805487227; 27286037 AB - Tea tree oil (TTO) is an essential oil obtained from the leaves of Melaleuca alternifolia, M. linariifolia, or M. dissitiflora. Because of the commercial importance of TTO, substitution or adulteration with other tea tree species (such as cajeput, niaouli, manuka, or kanuka oils) is common and may pose significant risks along with perceived health benefits. The distinctive nature, qualitative and quantitative compositional variation of these oils, is responsible for the various pharmacological as well as adverse effects. Authentic TTOs (especially aged ones) have been identified as potential skin sensitizers, while reports of adverse allergic reactions to the other tea trees essential oils are less frequent. Chemical sensitizers are usually electrophilic compounds, and in chemico methods have been developed to identify skin allergens in terms of their ability to bind to biological nucleophiles. However, little information is available on the assessment of sensitization potential of mixtures, such as essential oils, due to their complexity. In the present study, 10 "tea tree" oils and six major TTO constituents have been investigated for their sensitization potential using a fluorescence in chemico method. The reactivity of authentic TTOs was found to correlate with the age of the oils, while the majority of nonauthentic TTOs were less reactive, even after aging. Further thio-trapping experiments with DCYA and characterization by UHPLC-DAD-MS led to the identification of several possible DCYA-adducts which can be used to deduce the structure of the candidate reactive species. The major TTO components, terpinolene, α-terpinene, and terpinene-4-ol, were unstable under accelerated aging conditions, which led to the formation of several DCYA-adducts. JF - Chemical research in toxicology AU - Avonto, Cristina AU - Chittiboyina, Amar G AU - Wang, Mei AU - Vasquez, Yelkaira AU - Rua, Diego AU - Khan, Ikhlas A AD - The Center for Food Safety and Applied Nutrition, US Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States. Y1 - 2016/07/18/ PY - 2016 DA - 2016 Jul 18 SP - 1108 EP - 1117 VL - 29 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805487227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=In+Chemico+Evaluation+of+Tea+Tree+Essential+Oils+as+Skin+Sensitizers%3A+Impact+of+the+Chemical+Composition+on+Aging+and+Generation+of+Reactive+Species.&rft.au=Avonto%2C+Cristina%3BChittiboyina%2C+Amar+G%3BWang%2C+Mei%3BVasquez%2C+Yelkaira%3BRua%2C+Diego%3BKhan%2C+Ikhlas+A&rft.aulast=Avonto&rft.aufirst=Cristina&rft.date=2016-07-18&rft.volume=29&rft.issue=7&rft.spage=1108&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.5b00530 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00530 ER - TY - JOUR T1 - Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules. AN - 1803792049; 27385551 AB - The investigation of the complex processes involved in cellular differentiation must be based on unbiased, high throughput data processing methods to identify relevant biological pathways. A number of bioinformatics tools are available that can generate lists of pathways ranked by statistical significance (i.e. by p-value), while ideally it would be desirable to functionally score the pathways relative to each other or to other interacting parts of the system or process. We describe a new computational method (Network Activity Score Finder - NASFinder) to identify tissue-specific, omics-determined sub-networks and the connections with their upstream regulator receptors to obtain a systems view of the differentiation of human adipocytes. Adipogenesis of human SBGS pre-adipocyte cells in vitro was monitored with a transcriptomic data set comprising six time points (0, 6, 48, 96, 192, 384 hours). To elucidate the mechanisms of adipogenesis, NASFinder was used to perform time-point analysis by comparing each time point against the control (0 h) and time-lapse analysis by comparing each time point with the previous one. NASFinder identified the coordinated activity of seemingly unrelated processes between each comparison, providing the first systems view of adipogenesis in culture. NASFinder has been implemented into a web-based, freely available resource associated with novel, easy to read visualization of omics data sets and network modules. JF - Scientific reports AU - Nassiri, Isar AU - Lombardo, Rosario AU - Lauria, Mario AU - Morine, Melissa J AU - Moyseos, Petros AU - Varma, Vijayalakshmi AU - Nolen, Greg T AU - Knox, Bridgett AU - Sloper, Daniel AU - Kaput, Jim AU - Priami, Corrado AD - The Microsoft Research - University of Trento Centre for Computational and Systems Biology, Piazza Manifattura 1, 38068 Rovereto, Italy. ; Division of Systems Biology, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Nestlé Institute of Health Science, Lausanne, Switzerland. Y1 - 2016/07/07/ PY - 2016 DA - 2016 Jul 07 SP - 28851 VL - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803792049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Systems+view+of+adipogenesis+via+novel+omics-driven+and+tissue-specific+activity+scoring+of+network+functional+modules.&rft.au=Nassiri%2C+Isar%3BLombardo%2C+Rosario%3BLauria%2C+Mario%3BMorine%2C+Melissa+J%3BMoyseos%2C+Petros%3BVarma%2C+Vijayalakshmi%3BNolen%2C+Greg+T%3BKnox%2C+Bridgett%3BSloper%2C+Daniel%3BKaput%2C+Jim%3BPriami%2C+Corrado&rft.aulast=Nassiri&rft.aufirst=Isar&rft.date=2016-07-07&rft.volume=6&rft.issue=&rft.spage=28851&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep28851 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep28851 ER - TY - JOUR T1 - Pesticides Are Associated with Allergic and Non-Allergic Wheeze among Male Farmers. AN - 1826716877; 27384423 AB - Growing evidence suggests that pesticide use may contribute to respiratory symptoms. To evaluate the association of currently used pesticides with allergic and non-allergic wheeze among male farmers. Using the 2005-2010 interview data of the Agricultural Health Study, a prospective study of farmers in North Carolina and Iowa, we evaluated the association between allergic and non-allergic wheeze and self-reported use of 78 specific pesticides, reported by ≥ 1% of the 22,134 men interviewed. We used polytomous regression models adjusted for age, BMI, state, smoking, and current asthma, as well as for days applying pesticides and days driving diesel tractors. We defined allergic wheeze as reporting both wheeze and doctor-diagnosed hay fever (n=1,310, 6%) and non-allergic wheeze as reporting wheeze but not hay fever (n=3,939, 18%); men without wheeze were the referent. In models evaluating current use of specific pesticides, 19 pesticides were significantly associated (p<0.05) with allergic wheeze (18 positive, 1 negative) and 21 pesticides with non-allergic wheeze (19 positive, 2 negative); 11 pesticides with both. Seven pesticides (herbicides: 2,4-D and simazine; insecticides: carbaryl, dimethoate, disulfoton, and zeta-cypermethrin; and fungicide pyraclostrobin) had significantly different associations for allergic and non-allergic wheeze. In exposure-response models with up to five exposure categories, we saw evidence of an exposure-response relationship for several pesticides including the commonly used herbicides 2,4-D and glyphosate, the insecticides permethrin and carbaryl and the rodenticide warfarin. These results for farmers implicate several pesticides that are commonly used in agricultural and residential settings with adverse respiratory effects. JF - Environmental health perspectives AU - Hoppin, Jane A AU - Umbach, David M AU - Long, Stuart AU - London, Stephanie J AU - Henneberger, Paul K AU - Blair, Aaron AU - Alavanja, Michael AU - Beane Freeman, Laura E AU - Sandler, Dale P AD - Department of Biological Sciences and Center for Human Health and the Environment, North Carolina State University, Raleigh, NC. ; Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, RTP, NC. ; Westat, Durham, NC. ; Epidemiology Branch, National Institute of Environmental Health Sciences, RTP, NC. ; Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV. ; National Cancer Institute, Rockville, MD. Y1 - 2016/07/06/ PY - 2016 DA - 2016 Jul 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826716877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Pesticides+Are+Associated+with+Allergic+and+Non-Allergic+Wheeze+among+Male+Farmers.&rft.au=Hoppin%2C+Jane+A%3BUmbach%2C+David+M%3BLong%2C+Stuart%3BLondon%2C+Stephanie+J%3BHenneberger%2C+Paul+K%3BBlair%2C+Aaron%3BAlavanja%2C+Michael%3BBeane+Freeman%2C+Laura+E%3BSandler%2C+Dale+P&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2016-07-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Occupational Exposure to Pesticides and the Incidence of Lung Cancer in the Agricultural Health Study. AN - 1826716666; 27384818 AB - Occupational pesticide use is associated with lung cancer in some, but not all, epidemiologic studies. In the Agricultural Health Study (AHS), we previously reported positive associations between several pesticides and lung cancer incidence. We evaluated use of 43 pesticides and 654 lung cancer cases after ten years of additional follow-up in the AHS, a prospective cohort study comprised of 57,310 pesticide applicators from Iowa and North Carolina. Information about lifetime pesticide use and other factors was ascertained at enrollment (1993-1997) and updated with a follow-up questionnaire (1999-2005). Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI), adjusting for smoking (smoking status and pack-years), gender, and lifetime days of use of any pesticides. Hazard ratios were elevated in the highest exposure category of lifetime days of use for pendimethalin (1.50; 95% CI = 0.98-2.31), dieldrin (1.93; 95% CI = 0.70-5.30), and chlorimuron-ethyl (1.74; 95% CI = 1.02-2.96), although monotonic exposure-response gradients were not evident. The HRs for intensity-weighted lifetime days of use of these pesticides were similar. For parathion, the trend was statistically significant for intensity-weighted lifetime days (p=0.049) and borderline for lifetime days (p=0.073). None of the remaining pesticides evaluated were associated with lung cancer incidence. These analyses provide additional evidence for an association between pendimethalin, dieldrin, and parathion use and lung cancer risk. We found an association between chlorimuron-ethyl, a herbicide introduced in 1986, and lung cancer that has not been previously reported. Continued follow-up is warranted. JF - Environmental health perspectives AU - Bonner, Matthew R AU - Beane Freeman, Laura E AU - Hoppin, Jane A AU - Koutros, Stella AU - Sandler, Dale P AU - Lynch, Charles F AU - Hines, Cynthia J AU - Thomas, Kent AU - Blair, Aaron AU - Alavanja, Michael C R AD - Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, New York. ; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. ; Department of Biological Sciences, Center for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina. ; Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina. ; College of Public Health, University of Iowa, Iowa City, Iowa. ; Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. ; National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. Y1 - 2016/07/06/ PY - 2016 DA - 2016 Jul 06 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826716666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Occupational+Exposure+to+Pesticides+and+the+Incidence+of+Lung+Cancer+in+the+Agricultural+Health+Study.&rft.au=Bonner%2C+Matthew+R%3BBeane+Freeman%2C+Laura+E%3BHoppin%2C+Jane+A%3BKoutros%2C+Stella%3BSandler%2C+Dale+P%3BLynch%2C+Charles+F%3BHines%2C+Cynthia+J%3BThomas%2C+Kent%3BBlair%2C+Aaron%3BAlavanja%2C+Michael+C+R&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2016-07-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Differential Role of Leptin as an Immunomodulator in Controlling Visceral Leishmaniasis in Normal and Leptin-Deficient Mice. AN - 1802735362; 27114296 AB - Visceral leishmaniasis (VL) is caused by the protozoan parasite Leishmania donovani There are no vaccines and available drugs against leishmaniasis are toxic. Immunomodulators that specifically boost the anti-microbial activities of the immune cells could alleviate several of these limitations. Therefore, finding novel immunomodulators for VL therapy is a pressing need. This study is aimed to evaluate the immunomodulatory role of leptin, an adipocyte-derived hormone capable of regulating the immune response, in L. donovani-infected mice. We observed that recombinant leptin treatment reduced splenic parasite burden compared with non-treated infected normal mice. Decrease in parasite burden correlated with an induction of innate immune response in antigen-presenting cells that showed an increase in nitric oxide, enhanced pro-inflammatory cytokine (interferon gamma [IFNγ], interleukin12 [IL]12, and IL1β) response in the splenocytes, indicating host-protecting Th1 response mediated by leptin. Moreover, in infected normal mice, leptin treatment induced IFNγ production from both CD4(+) and CD8(+) T cells, compared with non-treated infected mice. Alternatively, leptin-deficient (Ob/Ob) mice had higher splenic and liver parasite burden compared with the infected normal mice. However, leptin treatment failed to reduce the splenic parasite burden and improve a host-protective cytokine response in these mice. In addition, in contrast to dendritic cells (DCs) from a normal mouse, Ob/Ob mouse-derived DCs showed a defect in the induction of innate immune response on Leishmania infection that could not be reversed by leptin treatment. Therefore, our findings reveal that leptin has a differential immunomodulatory effect in controlling VL in normal and Ob/Ob mice. © The American Society of Tropical Medicine and Hygiene. JF - The American journal of tropical medicine and hygiene AU - Maurya, Radheshyam AU - Bhattacharya, Parna AU - Ismail, Nevien AU - Dagur, Pradeep K AU - Joshi, Amritanshu B AU - Razdan, Kundan AU - McCoy, J Philip AU - Ascher, Jill AU - Dey, Ranadhir AU - Nakhasi, Hira L AD - Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. Department of Animal Biology, School of Life Science, University of Hyderabad, Hyderabad, India. rmusl@uohyd.ernet.in ranadhir.dey@fda.hhs.gov. ; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. ; Flow Cytometry Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. ; Division of Veterinary Services, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. ; Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. rmusl@uohyd.ernet.in ranadhir.dey@fda.hhs.gov. Y1 - 2016/07/06/ PY - 2016 DA - 2016 Jul 06 SP - 109 EP - 119 VL - 95 IS - 1 KW - Abridged Index Medicus KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802735362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+tropical+medicine+and+hygiene&rft.atitle=Differential+Role+of+Leptin+as+an+Immunomodulator+in+Controlling+Visceral+Leishmaniasis+in+Normal+and+Leptin-Deficient+Mice.&rft.au=Maurya%2C+Radheshyam%3BBhattacharya%2C+Parna%3BIsmail%2C+Nevien%3BDagur%2C+Pradeep+K%3BJoshi%2C+Amritanshu+B%3BRazdan%2C+Kundan%3BMcCoy%2C+J+Philip%3BAscher%2C+Jill%3BDey%2C+Ranadhir%3BNakhasi%2C+Hira+L&rft.aulast=Maurya&rft.aufirst=Radheshyam&rft.date=2016-07-06&rft.volume=95&rft.issue=1&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+tropical+medicine+and+hygiene&rft.issn=1476-1645&rft_id=info:doi/10.4269%2Fajtmh.15-0804 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.4269/ajtmh.15-0804 ER - TY - JOUR T1 - Intracellular accumulation and dissolution of silver nanoparticles in L-929 fibroblast cells using live cell time-lapse microscopy AN - 1808643699; PQ0003332007 AB - Cytotoxicity assessments of nanomaterials, such as silver nanoparticles, are challenging due to interferences with test reagents and indicators as well uncertainties in dosing as a result of the complex nature of nanoparticle intracellular accumulation. Furthermore, current theories suggest that silver nanoparticle cytotoxicity is a result of silver nanoparticle dissolution and subsequent ion release. This study introduces a novel technique, nanoparticle associated cytotoxicity microscopy analysis (NACMA), which combines fluorescence microscopy detection using ethidium homodimer-1, a cell permeability marker that binds to DNA after a cell membrane is compromised (a classical dead-cell indicator dye), with live cell time-lapse microscopy and image analysis to simultaneously investigate silver nanoparticle accumulation and cytotoxicity in L-929 fibroblast cells. Results of this method are consistent with traditional methods of assessing cytotoxicity and nanoparticle accumulation. Studies conducted on 10, 50, 100 and 200 nm silver nanoparticles reveal size dependent cytotoxicity with particularly high cytotoxicity from 10 nm particles. In addition, NACMA results, when combined with transmission electron microscopy imaging, reveal direct evidence of intracellular silver ion dissolution and possible nanoparticle reformation within cells for all silver nanoparticle sizes. JF - Nanotoxicology AU - Wildt, Bridget E AU - Celedon, Alfredo AU - Maurer, Elizabeth I AU - Casey, Brendan J AU - Nagy, Amber M AU - Hussain, Saber M AU - Goering, Peter L AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA Y1 - 2016/07/02/ PY - 2016 DA - 2016 Jul 02 SP - 710 EP - 719 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 10 IS - 6 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Transmission electron microscopy KW - Image processing KW - Cell permeability KW - imaging KW - Fibroblasts KW - Cytotoxicity KW - Cell membranes KW - DNA KW - Dissolution KW - nanoparticles KW - Silver KW - nanotechnology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808643699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Intracellular+accumulation+and+dissolution+of+silver+nanoparticles+in+L-929+fibroblast+cells+using+live+cell+time-lapse+microscopy&rft.au=Wildt%2C+Bridget+E%3BCeledon%2C+Alfredo%3BMaurer%2C+Elizabeth+I%3BCasey%2C+Brendan+J%3BNagy%2C+Amber+M%3BHussain%2C+Saber+M%3BGoering%2C+Peter+L&rft.aulast=Wildt&rft.aufirst=Bridget&rft.date=2016-07-02&rft.volume=10&rft.issue=6&rft.spage=710&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2015.1113321 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Cell membranes; Transmission electron microscopy; DNA; Image processing; Dissolution; Cell permeability; imaging; Silver; nanoparticles; nanotechnology; Fibroblasts DO - http://dx.doi.org/10.3109/17435390.2015.1113321 ER - TY - JOUR T1 - Performance of a scanning mobility particle sizer in measuring diverse types of airborne nanoparticles: Multi-walled carbon nanotubes, welding fumes, and titanium dioxide spray AN - 1808610435; PQ0003207501 AB - Direct-reading instruments have been widely used for characterizing airborne nanoparticles in inhalation toxicology and industrial hygiene studies for exposure/risk assessments. Instruments using electrical mobility sizing followed by optical counting, e.g., scanning or sequential mobility particle spectrometers (SMPS), have been considered as the "gold standard" for characterizing nanoparticles. An SMPS has the advantage of rapid response and has been widely used, but there is little information on its performance in assessing the full spectrum of nanoparticles encountered in the workplace. In this study, an SMPS was evaluated for its effectiveness in producing "monodisperse" aerosol and its adequacy in characterizing overall particle size distribution using three test aerosols, each mimicking a unique class of real-life nanoparticles: singlets of nearly spherical titanium dioxide (TiO sub(2)), agglomerates of fiber-like multi-walled carbon nanotube (MWCNT), and aggregates that constitutes welding fume (WF). These aerosols were analyzed by SMPS, cascade impactor, and by counting and sizing of discrete particles by scanning and transmission electron microscopy. The effectiveness of the SMPS to produce classified particles (fixed voltage mode) was assessed by examination of the resulting geometric standard deviation (GSD) from the impactor measurement. Results indicated that SMPS performed reasonably well for TiO sub(2) (GSD = 1.3), but not for MWCNT and WF as evidenced by the large GSD values of 1.8 and 1.5, respectively. For overall characterization, results from SMPS (scanning voltage mode) exhibited particle-dependent discrepancies in the size distribution and total number concentration compared to those from microscopic analysis. Further investigation showed that use of a single-stage impactor at the SMPS inlet could distort the size distribution and underestimate the concentration as shown by the SMPS, whereas the presence of vapor molecules or atom clusters in some test aerosols might cause artifacts by counting "phantom particles." Overall, the information obtained from this study will help understand the limitations of the SMPS in measuring nanoparticles so that one can adequately interpret the results for risk assessments and exposure prevention in an occupational or ambient environment. JF - Journal of Occupational and Environmental Hygiene AU - Chen, Bean T AU - Schwegler-Berry, Diane AU - Cumpston, Amy AU - Cumpston, Jared AU - Friend, Sherri AU - Stone, Samuel AU - Keane, Michael AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia Y1 - 2016/07/02/ PY - 2016 DA - 2016 Jul 02 SP - 501 EP - 518 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 7 SN - 1545-9624, 1545-9624 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Aerosols KW - Artifacts KW - Fumes KW - Mobility KW - Sprays KW - Measuring instruments KW - Particulates KW - Nanotechnology KW - Prevention KW - Titanium dioxide KW - Carbon KW - Microscopy KW - Welding KW - Hygiene KW - H 1000:Occupational Safety and Health KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808610435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Performance+of+a+scanning+mobility+particle+sizer+in+measuring+diverse+types+of+airborne+nanoparticles%3A+Multi-walled+carbon+nanotubes%2C+welding+fumes%2C+and+titanium+dioxide+spray&rft.au=Chen%2C+Bean+T%3BSchwegler-Berry%2C+Diane%3BCumpston%2C+Amy%3BCumpston%2C+Jared%3BFriend%2C+Sherri%3BStone%2C+Samuel%3BKeane%2C+Michael&rft.aulast=Chen&rft.aufirst=Bean&rft.date=2016-07-02&rft.volume=13&rft.issue=7&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1148267 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Risk assessment; Aerosols; Fumes; Artifacts; Mobility; Sprays; Particulates; Measuring instruments; Nanotechnology; Prevention; Carbon; Titanium dioxide; Microscopy; Welding; Hygiene DO - http://dx.doi.org/10.1080/15459624.2016.1148267 ER - TY - JOUR T1 - Respirable crystalline silica exposures during asphalt pavement milling at eleven highway construction sites AN - 1808610211; PQ0003207505 AB - Asphalt pavement milling machines use a rotating cutter drum to remove the deteriorated road surface for recycling. The removal of the road surface has the potential to release respirable crystalline silica, to which workers can be exposed. This article describes an evaluation of respirable crystalline silica exposures to the operator and ground worker from two different half-lane and larger asphalt pavement milling machines that had ventilation dust controls and water-sprays designed and installed by the manufacturers. Manufacturer A completed milling for 11 days at 4 highway construction sites in Wisconsin, and Manufacturer B completed milling for 10 days at 7 highway construction sites in Indiana. To evaluate the dust controls, full-shift personal breathing zone air samples were collected from an operator and ground worker during the course of normal employee work activities of asphalt pavement milling at 11 different sites. Forty-two personal breathing zone air samples were collected over 21 days (sampling on an operator and ground worker each day). All samples were below 50 mu g/m super(3) for respirable crystalline silica, the National Institute for Occupational Safety and Health recommended exposure limit. The geometric mean personal breathing zone air sample was 6.2 mu g/m super(3) for the operator and 6.1 mu g/m super(3) for the ground worker for the Manufacturer A milling machine. The geometric mean personal breathing zone air sample was 4.2 mu g/m super(3) for the operator and 9.0 mu g/m super(3) for the ground worker for the Manufacturer B milling machine. In addition, upper 95% confidence limits for the mean exposure for each occupation were well below 50 mu g/m super(3) for both studies. The silica content in the bulk asphalt material being milled ranged from 7-23% silica for roads milled by Manufacturer A and from 5-12% silica for roads milled by Manufacturer B. The results indicate that engineering controls consisting of ventilation controls in combination with water-sprays are capable of controlling occupational exposures to respirable crystalline silica generated by asphalt pavement milling machines on highway construction sites. JF - Journal of Occupational and Environmental Hygiene AU - Hammond, Duane R AU - Shulman, Stanley A AU - Echt, Alan S AD - National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio Y1 - 2016/07/02/ PY - 2016 DA - 2016 Jul 02 SP - 538 EP - 548 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 7 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Ventilation KW - Respiration KW - Occupational safety KW - USA, Wisconsin KW - Recycling KW - Dust KW - Waste management KW - USA, Indiana KW - Silica KW - Asphalt KW - Air sampling KW - Sampling KW - Highways KW - Construction industry KW - Occupational exposure KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808610211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Respirable+crystalline+silica+exposures+during+asphalt+pavement+milling+at+eleven+highway+construction+sites&rft.au=Hammond%2C+Duane+R%3BShulman%2C+Stanley+A%3BEcht%2C+Alan+S&rft.aulast=Hammond&rft.aufirst=Duane&rft.date=2016-07-02&rft.volume=13&rft.issue=7&rft.spage=538&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2016.1153803 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Silica; Ventilation; Asphalt; Respiration; Sampling; Recycling; Dust; Occupational exposure; Environmental hygiene; Occupational safety; Air sampling; Highways; Construction industry; Waste management; USA, Indiana; USA, Wisconsin DO - http://dx.doi.org/10.1080/15459624.2016.1153803 ER - TY - JOUR T1 - Isolation and Short-Term Persistence of Ehrlichia ewingii in Cell Culture AN - 1827883079; PQ0003681437 AB - Ehrlichia ewingii is the causative agent of human and canine granulocytic ehrlichiosis. Since its discovery in 1970, little work has been done to characterize the pathogen or study the transmission dynamics due to the inability to grow the agent in vitro. The aim of this study was to assess the suitability of multiple cell lines and media formulations for propagation of E. ewingii in cell culture. In this study, we present an overview of attempts to isolate E. ewingii from the buffy coat of goats naturally infected by Amblyomma americanum ticks, as well as a methodology for maintaining the pathogen for up to 16 weeks in culture. The most promising results were seen with HL-60 cells differentiated by the addition of 1.5% DMSO to the media and supplemented with 8mM l-glutamine. Cultures were passaged multiple times, and fluorescence and morulae were observed by indirect fluorescent antibody test and Diff-Quik staining. It is our hope that this information will provide a foundation for future attempts to propagate and maintain E. ewingii in cell culture. JF - Vector Borne and Zoonotic Diseases AU - Killmaster, Lindsay F AU - Levin, Michael L AD - Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 445 EP - 448 PB - Mary Ann Liebert, Inc., 2 Madison Ave Larchmont NY 10538-1962 United States VL - 16 IS - 7 SN - 1530-3667, 1530-3667 KW - Microbiology Abstracts B: Bacteriology KW - Cell culture KW - Ehrlichia ewingii KW - In vitro propagation KW - Glutamine KW - Fluorescence KW - Ixodidae KW - Buffy coat KW - Vectors KW - Ehrlichiosis KW - Pathogens KW - Disease transmission KW - Amblyomma americanum KW - Indirect fluorescent antibody test KW - Reviews KW - Media (culture) KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827883079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vector+Borne+and+Zoonotic+Diseases&rft.atitle=Isolation+and+Short-Term+Persistence+of+Ehrlichia+ewingii+in+Cell+Culture&rft.au=Killmaster%2C+Lindsay+F%3BLevin%2C+Michael+L&rft.aulast=Killmaster&rft.aufirst=Lindsay&rft.date=2016-07-01&rft.volume=16&rft.issue=7&rft.spage=445&rft.isbn=&rft.btitle=&rft.title=Vector+Borne+and+Zoonotic+Diseases&rft.issn=15303667&rft_id=info:doi/10.1089%2Fvbz.2015.1938 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 19 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Indirect fluorescent antibody test; Glutamine; Fluorescence; Reviews; Buffy coat; Vectors; Ehrlichiosis; Cell culture; Pathogens; Media (culture); Disease transmission; Amblyomma americanum; Ehrlichia ewingii; Ixodidae DO - http://dx.doi.org/10.1089/vbz.2015.1938 ER - TY - JOUR T1 - Activation of the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells. AN - 1826713920; 27369375 AB - Many usnic acid-containing dietary supplements have been marketed as weight loss agents, although severe hepatotoxicity and acute liver failure have been associated with their overuse. Our previous mechanistic studies revealed that autophagy, disturbance of calcium homeostasis, and ER stress are involved in usnic acid-induced toxicity. In this study, we investigated the role of oxidative stress and the Nrf2 signaling pathway in usnic acid-induced toxicity in HepG2 cells. We found that a 24-h treatment with usnic acid caused DNA damage and S-phase cell cycle arrest in a concentration-dependent manner. Usnic acid also triggered oxidative stress as demonstrated by increased reactive oxygen species generation and glutathione depletion. Short-term treatment (6 h) with usnic acid significantly increased the protein level for Nrf2 (nuclear factor erythroid 2-related factor 2), promoted Nrf2 translocation to the nucleus, up-regulated antioxidant response element (ARE)-luciferase reporter activity, and induced the expression of Nrf2-regulated targets, including glutathione reductase, glutathione S-transferase, and NAD(P)H quinone oxidoreductase-1 (NQO1). Furthermore, knockdown of Nrf2 with shRNA potentiated usnic acid-induced DNA damage and cytotoxicity. Taken together, our results show that usnic acid causes cell cycle dysregulation, DNA damage, and oxidative stress and that the Nrf2 signaling pathway is activated in usnic acid-induced cytotoxicity. JF - Archives of toxicology AU - Chen, Si AU - Zhang, Zhuhong AU - Qing, Tao AU - Ren, Zhen AU - Yu, Dianke AU - Couch, Letha AU - Ning, Baitang AU - Mei, Nan AU - Shi, Leming AU - Tolleson, William H AU - Guo, Lei AD - Division of Biochemical Toxicology, National Center for Toxicological Research (NCTR)/U.S. Food and Drug Administration (FDA), HFT-110, 3900 NCTR Road, Jefferson, AR, 72079, USA. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR, 72079, USA. ; School of Pharmacy, School of Life Sciences, Fudan-Zhangjiang Center for Clinical Genomics and Zhanjiang Center for Translational Medicine, Fudan University, Shanghai, 200438, China. ; Division of Systems Biology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR, 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research (NCTR)/U.S. Food and Drug Administration (FDA), HFT-110, 3900 NCTR Road, Jefferson, AR, 72079, USA. lei.guo@fda.hhs.gov. Y1 - 2016/07/01/ PY - 2016 DA - 2016 Jul 01 KW - Liver toxicity KW - Nrf2 pathway KW - Oxidative stress KW - Usnic acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826713920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Activation+of+the+Nrf2+signaling+pathway+in+usnic+acid-induced+toxicity+in+HepG2+cells.&rft.au=Chen%2C+Si%3BZhang%2C+Zhuhong%3BQing%2C+Tao%3BRen%2C+Zhen%3BYu%2C+Dianke%3BCouch%2C+Letha%3BNing%2C+Baitang%3BMei%2C+Nan%3BShi%2C+Leming%3BTolleson%2C+William+H%3BGuo%2C+Lei&rft.aulast=Chen&rft.aufirst=Si&rft.date=2016-07-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Hybrid Shiga Toxin-Producing and Enterotoxigenic Escherichia sp. Cryptic Lineage 1 Strain 7v Harbors a Hybrid Plasmid AN - 1811898606; PQ0003494136 AB - Hybrid isolates of Shiga toxin-producing Escherichia coli (STEC) and enterotoxigenic E. coli (ETEC) encoding heat-stable enterotoxin (ST) are being reported with increasing frequency from a variety of sources. However, information regarding the plasmids that these strains harbor is scarce. In this study, we sequence and characterize a plasmid, p7v, from the STEC/ETEC hybrid strain 7v. Whole-genome phylogenetic analyses of STEC/ETEC hybrid strains and prototype E. coli isolates of other pathotypes placed 7v in the Escherichia sp. cryptic lineage 1 (CL1) clade. The complete plasmid, p7v, was determined to be 229,275 bp and encodes putative virulence factors that are typically carried on STEC plasmids as well as those often carried on ETEC plasmids, indicating that the hybrid nature of the strain extends beyond merely encoding the two toxins. Plasmid p7v carries two copies of sta with identical sequences, which were discovered to be divergent from the sta sequences found in the prototype human ETEC strains. Using a nomenclature scheme based on a phylogeny constructed from sta and stb sequences, the sta encoded on p7v is designated STa4. In silico analysis determined that p7v also encodes the K88 fimbria, a colonization factor usually associated with porcine ETEC plasmids. The p7v sequence and the presence of plasmid-encoded virulence factors are compared to those of other STEC/ETEC CL1 hybrid genomes and reveal gene acquisition/loss at the strain level. In addition, the interrogation of 24 STEC/ETEC hybrid genomes for identification of plasmid replicons, colonization factors, Stx and ST subtypes, and other plasmid-encoded virulence genes highlights the diversity of these hybrid strains. IMPORTANCE Hybrid Shiga toxin-producing Escherichia coli/enterotoxigenic Escherichia coli (STEC/ETEC) strains, which have been isolated from environmental, animal, and human clinical samples, may represent an emerging threat as food-borne pathogens. Characterization of these strains is important for assessing virulence potential, aiding in the development of pathogen detection methods, and understanding how the hybrid strains evolve to potentially have a greater impact on public health. This study represents, to our knowledge, both the first characterization of a closed plasmid sequence from a STEC/ETEC hybrid strain and the most comprehensive phylogenetic analysis of available STEC/ETEC hybrid genomes to date. The results demonstrate how the mobility of plasmid-associated virulence genes has resulted in the creation of a diverse plasmid repertoire within the STEC/ETEC hybrid strains. JF - Antimicrobial Agents & Chemotherapy AU - Leonard, Susan R AU - Mammel, Mark K AU - Rasko, David A AU - Lacher, David W AD - << + $0, susan.leonard@fda.hhs.gov. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 4309 EP - 4319 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 14 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Nomenclature KW - Phylogeny KW - Genomes KW - Mobility KW - virulence factors KW - Food KW - Pathogens KW - Plasmids KW - Toxins KW - Public health KW - Hybrids KW - Escherichia coli KW - Enterotoxins KW - Thermal stability KW - Fimbria KW - Colonization factor KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811898606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Hybrid+Shiga+Toxin-Producing+and+Enterotoxigenic+Escherichia+sp.+Cryptic+Lineage+1+Strain+7v+Harbors+a+Hybrid+Plasmid&rft.au=Leonard%2C+Susan+R%3BMammel%2C+Mark+K%3BRasko%2C+David+A%3BLacher%2C+David+W&rft.aulast=Leonard&rft.aufirst=Susan&rft.date=2016-07-01&rft.volume=82&rft.issue=14&rft.spage=4309&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01129-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 52 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Genomes; Phylogeny; Nomenclature; virulence factors; Mobility; Food; Pathogens; Plasmids; Toxins; Public health; Hybrids; Enterotoxins; Thermal stability; Colonization factor; Escherichia coli; Fimbria DO - http://dx.doi.org/10.1128/AEM.01129-16 ER - TY - JOUR T1 - A retrospective review of the economic impact of the food and drug administration's proposed egg rule AN - 1808684343; PQ0003373878 AB - Using novel 1998-2008 data collected by the Centers for Disease Control and Prevention on foodborne illnesses and outbreaks, we test using a difference-in-differences approach whether the Food and Drug Administration's proposed rule entitled "Prevention of Salmonella Enteritidis in Shell Eggs During Production" decreased the number of Salmonella illnesses associated with the consumption of shell eggs. We find that this rule led to a reduction in the number of Salmonella illnesses of between 308 and 434 illnesses per year, which we attribute to a reduction in the number of outbreaks associated with egg-containing products rather than a reduction in the average number of illnesses reported in each outbreak. JF - Agricultural Economics AU - Minor, Travis AU - Parrett, Matt AD - Food and Drug Administration, Office of the Commissioner, 5100 Paint Branch Parkway, College Park, MD, 20740, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 457 EP - 464 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 47 IS - 4 SN - 0169-5150, 0169-5150 KW - Environment Abstracts KW - Prevention KW - Reviews KW - Economics KW - Disease control KW - Outbreaks KW - Food contamination KW - Drugs KW - Salmonella enteritidis KW - Eggs KW - Food-borne diseases KW - ENA 06:Food & Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808684343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Agricultural+Economics&rft.atitle=A+retrospective+review+of+the+economic+impact+of+the+food+and+drug+administration%27s+proposed+egg+rule&rft.au=Minor%2C+Travis%3BParrett%2C+Matt&rft.aulast=Minor&rft.aufirst=Travis&rft.date=2016-07-01&rft.volume=47&rft.issue=4&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=Agricultural+Economics&rft.issn=01695150&rft_id=info:doi/10.1111%2Fagec.12244 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Prevention; Reviews; Economics; Disease control; Outbreaks; Food contamination; Drugs; Food-borne diseases; Eggs; Salmonella enteritidis DO - http://dx.doi.org/10.1111/agec.12244 ER - TY - JOUR T1 - A Flow Cytometry Method for Rapidly Assessing Mycobacterium tuberculosis Responses to Antibiotics with Different Modes of Action AN - 1808679754; PQ0003483843 AB - Current methods for assessing the drug susceptibility of Mycobacterium tuberculosis are lengthy and do not capture information about viable organisms that are not immediately culturable under standard laboratory conditions as a result of antibiotic exposure. We have developed a rapid dual-fluorescence flow cytometry method using markers for cell viability and death. We show that the fluorescent marker calcein violet with an acetoxy-methyl ester group (CV-AM) can differentiate between populations of M. tuberculosis growing at different rates, while Sytox green (SG) can differentiate between live and dead mycobacteria. M. tuberculosis was exposed to isoniazid or rifampin at different concentrations over time and either dual stained with CV-AM and SG and analyzed by flow cytometry or plated to determine the viability of the cells. Although similar trends in the loss of viability were observed when the results of flow cytometry and the plate counting methods were compared, there was a lack of correlation between these two approaches, as the flow cytometry analysis potentially captured information about cell populations that were unable to grow under standard conditions. The flow cytometry approach had an additional advantage in that it could provide insights into the mode of action of the drug: antibiotics targeting the cell wall gave a flow cytometry profile distinct from those inhibiting intracellular processes. This rapid drug susceptibility testing method could identify more effective antimycobacterials, provide information about their potential mode of action, and accelerate their progress to the clinic. JF - Antimicrobial Agents & Chemotherapy AU - Hendon-Dunn, Charlotte Louise AU - Doris, Kathryn Sarah AU - Thomas, Stephen Richard AU - Allnutt, Jonathan Charles AU - Neville Marriott, Alice Ann AU - Hatch, Kim Alexandra AU - Watson, Robert James AU - Bottley, Graham AU - Marsh, Philip David AU - Taylor, Stephen Charles AD - << + $0, joanna.bacon@phe.gov.uk. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 3869 EP - 3883 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 60 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Drug delivery KW - Calcein KW - Counting methods KW - Antibiotics KW - Drug screening KW - Esters KW - Flow cytometry KW - Rifampin KW - Fluorescent indicators KW - Tuberculosis KW - Drugs KW - Mycobacterium tuberculosis KW - Cell walls KW - Isoniazid KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808679754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=A+Flow+Cytometry+Method+for+Rapidly+Assessing+Mycobacterium+tuberculosis+Responses+to+Antibiotics+with+Different+Modes+of+Action&rft.au=Hendon-Dunn%2C+Charlotte+Louise%3BDoris%2C+Kathryn+Sarah%3BThomas%2C+Stephen+Richard%3BAllnutt%2C+Jonathan+Charles%3BNeville+Marriott%2C+Alice+Ann%3BHatch%2C+Kim+Alexandra%3BWatson%2C+Robert+James%3BBottley%2C+Graham%3BMarsh%2C+Philip+David%3BTaylor%2C+Stephen+Charles&rft.aulast=Hendon-Dunn&rft.aufirst=Charlotte&rft.date=2016-07-01&rft.volume=60&rft.issue=7&rft.spage=3869&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.02712-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 57 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Drug delivery; Calcein; Counting methods; Antibiotics; Esters; Drug screening; Flow cytometry; Rifampin; Fluorescent indicators; Tuberculosis; Drugs; Isoniazid; Cell walls; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/AAC.02712-15 ER - TY - JOUR T1 - Induction of Unconventional T Cells by a Mutant Mycobacterium bovis BCG Strain Formulated in Cationic Liposomes Correlates with Protection against Mycobacterium tuberculosis Infections of Immunocompromised Mice AN - 1808675394; PQ0003406209 AB - Earlier studies aimed at defining protective immunity induced by Mycobacterium bovis BCG immunization have largely focused on the induction of antituberculosis CD4+ and CD8+ T cell responses. Here we describe a vaccine consisting of a BCG Delta mmaA4 deletion mutant formulated in dimethyl dioctadecyl-ammonium bromide (DDA) with d-(+)-trehalose 6,6'-dibehenate (TDB) (DDA/TDB) adjuvant (A4/Adj) that protected TCR delta -/- mice depleted of CD4+, CD8+, and NK1.1+ T cells against an aerosol challenge with M. tuberculosis. These mice were significantly protected relative to mice immunized with a nonadjuvanted BCG Delta mmaA4 (BCG-A4) mutant and nonvaccinated controls at 2 months and 9 months postvaccination. In the absence of all T cells following treatment with anti-Thy1.2 antibody, the immunized mice lost the ability to control the infection. These results indicate that an unconventional T cell population was mediating protection in the absence of CD4+, CD8+, NK1.1+, and TCR gamma delta T cells and could exhibit memory. Focusing on CD4- CD8- double-negative (DN) T cells, we found that these cells accumulated in the lungs postchallenge significantly more in A4/Adj-immunized mice and induced significantly greater frequencies of pulmonary gamma interferon (IFN- gamma )-producing cells than were seen in the nonvaccinated or nonadjuvanted BCG control groups. Moreover, pulmonary DN T cells from the A4/Adj group exhibited significantly higher IFN- gamma integrated median fluorescence intensity (iMFI) values than were seen in the control groups. We also showed that enriched DN T cells from mice immunized with A4/Adj could control mycobacterial growth in vitro significantly better than naive whole-spleen cells. These results suggest that formulating BCG in DDA/TDB adjuvant confers superior protection in immunocompromised mice and likely involves the induction of long-lived memory DN T cells. JF - Clinical and Vaccine Immunology AU - Derrick, Steven C AU - Yabe, Idalia AU - Morris, Sheldon AU - Cowley, Siobhan AD - << + $0, steven.derrick@fda.hhs.gov. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 638 EP - 647 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 23 IS - 7 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Aerosols KW - T-cell receptor KW - Fluorescence KW - Deletion mutant KW - Memory cells KW - Immunological memory KW - Mycobacterium bovis KW - Adjuvants KW - CD8 antigen KW - Infection KW - bromides KW - Liposomes KW - Immunization KW - CD4 antigen KW - Antibodies KW - Lung KW - BCG KW - Lymphocytes T KW - Tuberculosis KW - Vaccines KW - Mycobacterium tuberculosis KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808675394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Induction+of+Unconventional+T+Cells+by+a+Mutant+Mycobacterium+bovis+BCG+Strain+Formulated+in+Cationic+Liposomes+Correlates+with+Protection+against+Mycobacterium+tuberculosis+Infections+of+Immunocompromised+Mice&rft.au=Derrick%2C+Steven+C%3BYabe%2C+Idalia%3BMorris%2C+Sheldon%3BCowley%2C+Siobhan&rft.aulast=Derrick&rft.aufirst=Steven&rft.date=2016-07-01&rft.volume=23&rft.issue=7&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00232-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 39 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; T-cell receptor; Aerosols; Deletion mutant; Fluorescence; Immunological memory; Memory cells; CD8 antigen; Adjuvants; bromides; Infection; Liposomes; Immunization; Antibodies; CD4 antigen; BCG; Lung; Lymphocytes T; Tuberculosis; Vaccines; Mycobacterium bovis; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/CVI.00232-16 ER - TY - JOUR T1 - Virulence Gene Profiles and Clonal Relationships of Escherichia coli O26:H11 Isolates from Feedlot Cattle as Determined by Whole-Genome Sequencing AN - 1808671070; PQ0003406231 AB - Escherichia coli O26 is the second most important enterohemorrhagic E. coli (EHEC) serogroup worldwide. Serogroup O26 strains are categorized mainly into two groups: enteropathogenic (EPEC) O26, carrying a locus of enterocyte effacement (LEE) and mostly causing mild diarrhea, and Shiga-toxigenic (STEC) O26, which carries the Shiga toxin (STX) gene (stx), responsible for more severe outcomes. stx-negative O26 strains can be further split into two groups. One O26 group differs significantly from O26 EHEC, while the other O26 EHEC-like group shows all the characteristics of EHEC O26 except production of STX. In order to determine the different populations of O26 E. coli present in U.S. cattle, we sequenced 42 O26:H11 strains isolated from feedlot cattle and compared them to 37 O26:H11 genomes available in GenBank. Phylogenetic analysis by whole-genome multilocus sequence typing (wgMLST) showed that O26:H11/H- strains in U.S. cattle were highly diverse. Most strains were sequence type 29 (ST29). By wgMLST, two clear lineages could be distinguished among cattle strains. Lineage 1 consisted of O26:H11 EHEC-like strains (ST29) (4 strains) and O26:H11 EHEC strains (ST21) (2 strains), and lineage 2 (36 strains) consisted of O26:H11 EPEC strains (ST29). Overall, our analysis showed U.S. cattle carried pathogenic (ST21; stx1+ ehxA+ toxB+) and also potentially pathogenic (ST29; ehxA+ toxB+) O26:H11 E. coli strains. Furthermore, in silico analysis showed that 70% of the cattle strains carried at least one antimicrobial resistance gene. Our results showed that whole-genome sequence analysis is a robust and valid approach to identify and genetically characterize E. coli O26:H11, which is of importance for food safety and public health. IMPORTANCE Escherichia coli O26 is the second most important type of enterohemorrhagic E. coli (EHEC) worldwide. Serogroup O26 strains are categorized into two groups: enteropathogenic (EPEC) carrying LEE, causing mild diarrhea, and Shiga toxigenic (STEC) carrying the stx gene, responsible for more severe outcomes. However, there are currently problems in distinguishing one group from the other. Furthermore, several O26 stx-negative strains are consistently misidentified as either EHEC-like or EPEC. The use of whole-genome sequence (WGS) analysis of O26 strains from cattle in the United States (i) allowed identification of O26 strains present in U.S. cattle, (ii) determined O26 strain diversity, (iii) solved the misidentification problem, and (iv) screened for the presence of antimicrobial resistance and virulence genes in the strains. This study provided a framework showing how to easily and rapidly use WGS information to identify and genetically characterize E. coli O26:H11, which is important for food safety and public health. JF - Antimicrobial Agents & Chemotherapy AU - Gonzalez-Escalona, Narjol AU - Toro, Magaly AU - Rump, Lydia V AU - Cao, Guojie AU - Nagaraja, T G AU - Meng, Jianghong AD - << + $0, narjol.gonzalez-escalona@fda.hhs.gov. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 3900 EP - 3912 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 13 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Phylogeny KW - Diarrhea KW - Drug resistance KW - Food KW - Public health KW - multilocus sequence typing KW - Virulence KW - stx gene KW - Escherichia coli KW - Enterocytes KW - Shiga toxin KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - N 14815:Nucleotide Sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808671070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Virulence+Gene+Profiles+and+Clonal+Relationships+of+Escherichia+coli+O26%3AH11+Isolates+from+Feedlot+Cattle+as+Determined+by+Whole-Genome+Sequencing&rft.au=Gonzalez-Escalona%2C+Narjol%3BToro%2C+Magaly%3BRump%2C+Lydia+V%3BCao%2C+Guojie%3BNagaraja%2C+T+G%3BMeng%2C+Jianghong&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2016-07-01&rft.volume=82&rft.issue=13&rft.spage=3900&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00498-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 55 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Phylogeny; Genomes; stx gene; Virulence; Diarrhea; Food; Drug resistance; Shiga toxin; Enterocytes; multilocus sequence typing; Public health; Escherichia coli DO - http://dx.doi.org/10.1128/AEM.00498-16 ER - TY - JOUR T1 - Direct determination of glyphosate, glufosinate, and AMPA in soybean and corn by liquid chromatography/tandem mass spectrometry AN - 1808667300; PQ0003331338 AB - Glyphosate, glufosinate, and aminomethylphosphonic acid (AMPA) are amphoteric, low mass, high water soluble, and do not have chromophore. They are very difficult to be retained on a reversed phase HPLC and detected by UV or fluorescence detectors. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed to determine these analytes in soybean and corn using a reversed phase with weak anion-exchange and cation-exchange mixed-mode Acclaim(TM) Trinity(TM) Q1 column. The sample was shaken with water containing ethylenediaminetetraacetic acid disodium salt (Na sub(2)EDTA) and acetic acid for 10 min to precipitate protein and extract the analytes into the solution. The supernatant was passed thru an Oasis HLB SPE to retain suspended particulates and non-polar interferences. The sample was directly injected and analyzed in 6 min by LC-MS/MS with no sample concentration or derivatization steps. Three isotopically labeled internal standards corresponding to each analyte were used to counter matrix suppression effect. Linearity of the detector response with a minimum coefficient of determination (R super(2)) of more than 0.995 was demonstrated in the range of 10 to 1000 ng/mL for each analyte. Accuracy (recovery %) and precision (relative standard deviation or RSD %) were evaluated at the fortification levels of 0.1, 0.5, and 2 mu g/g in seven replicates in both soybean and corn samples. JF - Analytical and Bioanalytical Chemistry AU - Chamkasem, Narong AU - Harmon, Tiffany AD - Southeast Regional Laboratory, U.S. Food and Drug Administration, 60 Eighth Street, N.E., Atlanta, GA, 30309, USA, narong.chamkasem@fda.hhs.gov Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 4995 EP - 5004 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 408 IS - 18 SN - 1618-2642, 1618-2642 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - High-performance liquid chromatography KW - Fluorescence KW - Chromophores KW - Acetic acid KW - Mass spectroscopy KW - Soybeans KW - Salts KW - glufosinate KW - Standard deviation KW - Liquid chromatography KW - alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid KW - Glyphosate KW - X 24330:Agrochemicals KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808667300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Direct+determination+of+glyphosate%2C+glufosinate%2C+and+AMPA+in+soybean+and+corn+by+liquid+chromatography%2Ftandem+mass+spectrometry&rft.au=Chamkasem%2C+Narong%3BHarmon%2C+Tiffany&rft.aulast=Chamkasem&rft.aufirst=Narong&rft.date=2016-07-01&rft.volume=408&rft.issue=18&rft.spage=4995&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-016-9597-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 16 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Salts; Fluorescence; Standard deviation; glufosinate; Liquid chromatography; alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; Chromophores; Acetic acid; Glyphosate; Mass spectroscopy; Soybeans DO - http://dx.doi.org/10.1007/s00216-016-9597-6 ER - TY - JOUR T1 - Air pollution in perspective: Health risks of air pollution expressed in equivalent numbers of passively smoked cigarettes AN - 1808641733; PQ0003166157 AB - Background Although the health effects of long term exposure to air pollution are well established, it is difficult to effectively communicate the health risks of this (largely invisible) risk factor to the public and policy makers. The purpose of this study is to develop a method that expresses the health effects of air pollution in an equivalent number of daily passively smoked cigarettes. Methods Defined changes in PM2.5, nitrogen dioxide (NO2) and Black Carbon (BC) concentration were expressed into number of passively smoked cigarettes, based on equivalent health risks for four outcome measures: Low Birth Weight (<2500g at term), decreased lung function (FEV1), cardiovascular mortality and lung cancer. To describe the strength of the relationship with ETS and air pollutants, we summarized the epidemiological literature using published or new meta-analyses. Results Realistic increments of 10 mu g/m3 in PM2.5 and NO2 concentration and a 1 mu g/m3 increment in BC concentration correspond to on average (standard error in parentheses) 5.5 (1.6), 2.5 (0.6) and 4.0 (1.2) passively smoked cigarettes per day across the four health endpoints, respectively. The uncertainty reflects differences in equivalence between the health endpoints and uncertainty in the concentration response functions. The health risk of living along a major freeway in Amsterdam is, compared to a counterfactual situation with 'clean' air, equivalent to 10 daily passively smoked cigarettes.. Conclusions We developed a method that expresses the health risks of air pollution and the health benefits of better air quality in a simple, appealing manner. The method can be used both at the national/regional and the local level. Evaluation of the usefulness of the method as a communication tool is needed. JF - Environmental Research AU - van der Zee, Saskia C AU - Fischer, Paul H AU - Hoek, Gerard AD - Public Health Service of Amsterdam, Department of Environmental Health, P.O. Box 2200, 1000 CE Amsterdam, The Netherlands Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 475 EP - 483 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 148 SN - 0013-9351, 0013-9351 KW - Toxicology Abstracts; Pollution Abstracts; Environment Abstracts KW - BC black carbon KW - CRF concentration response function KW - ETS environmental tobacco smoke KW - FEV1 Forced Expiratory Volume in 1s KW - LBW Low Birth Weight (Birthweight 2500g after 37 weeks of gestation) KW - IHD ischaemic heart disease KW - NO2 nitrogen dioxide KW - OR odds ratio KW - PM2.5 particles smaller than 2.5 mu m KW - PM10 particles smaller than 10 mu m KW - RAP risk advancement period KW - RR relative risk KW - YLL years of life lost KW - Air quality KW - Environmental tobacco smoke (ETS) KW - Particulate matter KW - Traffic KW - Health impact evaluation KW - Birth weight KW - Cigarettes KW - Communication KW - Pollution effects KW - Nitrogen dioxide KW - Pollutants KW - black carbon KW - Risk factors KW - Respiratory function KW - Highways KW - Lung cancer KW - Particle size KW - Mortality KW - Cancer KW - Air pollution KW - Health risks KW - ANE, Netherlands, Noord-Holland, Amsterdam KW - Low-birth-weight KW - Communications KW - Reviews KW - Cardiovascular diseases KW - X 24380:Social Poisons & Drug Abuse KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808641733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Air+pollution+in+perspective%3A+Health+risks+of+air+pollution+expressed+in+equivalent+numbers+of+passively+smoked+cigarettes&rft.au=van+der+Zee%2C+Saskia+C%3BFischer%2C+Paul+H%3BHoek%2C+Gerard&rft.aulast=van+der+Zee&rft.aufirst=Saskia&rft.date=2016-07-01&rft.volume=148&rft.issue=&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2016.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Nitrogen dioxide; Air pollution; Mortality; Birth weight; black carbon; Pollutants; Cigarettes; Risk factors; Reviews; Communication; Cardiovascular diseases; Lung cancer; Particle size; Pollution effects; Air quality; Cancer; Health risks; Communications; Low-birth-weight; Respiratory function; Highways; ANE, Netherlands, Noord-Holland, Amsterdam DO - http://dx.doi.org/10.1016/j.envres.2016.04.001 ER - TY - JOUR T1 - Regional investigation of a cyclosporiasis outbreak linked to imported romaine lettuce - Nebraska and Iowa, June-August 2013 AN - 1808620298; PQ0003309257 AB - A regional, multistate investigation into a June-August 2013 cyclosporiasis outbreak was conducted in Nebraska, Iowa, and neighbouring states. Cases were confirmed on the basis of laboratory and clinical findings. Of 227 cases in Iowa (n = 140) and Nebraska (n = 87) residents, 162 (71%) reported dining at chain A/B restaurants - 96% reported house salad consumption. A case-control study identified chain A/B house salad as the most likely vehicle. Traceback was conducted to ascertain production lot codes of bagged salad mix (iceberg and romaine lettuce, red cabbage, and carrots) served as house salad in implicated restaurants. A single production lot code of salad mix supplied by both a common producer and distributor was linked to the majority of confirmed cases in persons reporting regional chain A/B exposure. The salad mix linked to illnesses contained imported romaine lettuce from two separate single-grower fields-of-origin and 1 additional field from another grower. JF - Epidemiology and Infection AU - Buss, B F AU - Joshi, M V AU - O'Keefe, Al AU - Allensworth, C D AU - Garvey, A AU - Obbink, K AU - Mandernach, S AU - Safranek, T J AD - Division of Public Health, Nebraska Department of Health and Human Services, Lincoln, NE, USA, bryan.buss@nebraska.gov Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 1807 EP - 1817 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 144 IS - 9 SN - 0950-2688, 0950-2688 KW - Health & Safety Science Abstracts KW - Housing KW - USA, Iowa KW - USA, Nebraska KW - Residential areas KW - Daucus KW - Lactuca sativa KW - Outbreaks KW - Brassica KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808620298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Regional+investigation+of+a+cyclosporiasis+outbreak+linked+to+imported+romaine+lettuce+-+Nebraska+and+Iowa%2C+June-August+2013&rft.au=Buss%2C+B+F%3BJoshi%2C+M+V%3BO%27Keefe%2C+Al%3BAllensworth%2C+C+D%3BGarvey%2C+A%3BObbink%2C+K%3BMandernach%2C+S%3BSafranek%2C+T+J&rft.aulast=Buss&rft.aufirst=B&rft.date=2016-07-01&rft.volume=144&rft.issue=9&rft.spage=1807&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268815002484 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 4 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Housing; Residential areas; Outbreaks; Daucus; Lactuca sativa; Brassica; USA, Iowa; USA, Nebraska DO - http://dx.doi.org/10.1017/S0950268815002484 ER - TY - JOUR T1 - Mortality from neurodegenerative diseases in a cohort of US flight attendants AN - 1808618779; PQ0003269724 AB - Background Concern exists about the potential chronic neurological effects among aircrew of exposure to chemical contaminants from engine oil in aircraft cabin air. We evaluated mortality from neurodegenerative diseases among 11,311 former US flight attendants. Methods Vital status was ascertained through 2007, and life table analyses were conducted to obtain standardized mortality ratios (SMRs). Results Amyotrophic lateral sclerosis (ALS) mortality was over twice as high in the cohort as in the US general population, based on nine observed ALS deaths. There was no clear pattern in risk when SMRs for ALS were stratified by exposure duration. Mortality from other neurodegenerative diseases was not elevated. Conclusions Our findings are limited due to small numbers of observed deaths and reliance on mortality data, but suggest that flight attendants may have an increased risk of ALS. Additional research is needed. Am. J. Ind. Med. 59:532-537, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Pinkerton, Lynne E AU - Hein, Misty J AU - Grajewski, Barbara AU - Kamel, Freya AD - Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 532 EP - 537 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 7 SN - 0271-3586, 0271-3586 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Oil KW - Mortality KW - USA KW - Aircraft KW - Standards KW - Chemical pollution KW - P 9999:GENERAL POLLUTION KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808618779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+from+neurodegenerative+diseases+in+a+cohort+of+US+flight+attendants&rft.au=Pinkerton%2C+Lynne+E%3BHein%2C+Misty+J%3BGrajewski%2C+Barbara%3BKamel%2C+Freya&rft.aulast=Pinkerton&rft.aufirst=Lynne&rft.date=2016-07-01&rft.volume=59&rft.issue=7&rft.spage=532&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22608 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Oil; Mortality; Aircraft; Standards; Chemical pollution; USA DO - http://dx.doi.org/10.1002/ajim.22608 ER - TY - JOUR T1 - Assessing the impact of a nurse-delivered home dried blood spot service on uptake of testing for household contacts of hepatitis B-infected pregnant women across two London trusts AN - 1808613127; PQ0003320294 AB - Despite national guidance recommending testing and vaccination of household contacts of hepatitis B-infected pregnant women, provision and uptake of this is sub-optimal. The aim of this study was to evaluate the use of in-home dried blood spot (DBS) testing to increase testing and vaccination of household contacts of hepatitis B-infected pregnant women as an alternative approach to conventional primary-care follow-up. The study was conducted across two London maternity trusts (North Middlesex and Newham). All hepatitis B surface antigen-positive pregnant women identified through these trusts were eligible for inclusion. The intervention of in-home DBS testing for household contacts was introduced at North Middlesex Trust from November 2010 to December 2011. Data on testing and vaccination uptake from GP records across the two trusts were compared between baseline (2009) and intervention (2010-2011) periods. In-home DBS service increased testing uptake for all ages (P < 0.001) with the biggest impact seen in partners, where testing increased from 30.3% during the baseline period to 96.6% during the intervention period in North Middlesex Trust. Although impact on vaccine uptake was less marked, improvements were observed for adults. The provision of nurse-led home-based DBS may be useful in areas of high prevalence. JF - Epidemiology and Infection AU - Keel, P AU - Edwards, G AU - Flood, J AU - Nixon, G AU - Beebeejaun, K AU - Shute, J AU - Poh, J AU - Millar, A AU - Ijaz, S AU - Parry, J AU - Mandal, S AU - Ramsay, M AU - Amirthalingam, G AD - Immunisation, Hepatitis and Blood Safety Department, Centre for Infectious Disease Surveillance & Control (CIDSC), Public Health England, UK, philip.keel@phe.gov.uk Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 2087 EP - 2097 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 144 IS - 10 SN - 0950-2688, 0950-2688 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Age KW - Data processing KW - Hepatitis B virus KW - British Isles, England, Greater London, London KW - Intervention KW - Vaccination KW - Pregnancy KW - Hepatitis KW - Blood KW - Hepatitis B KW - Uptake KW - Females KW - Vaccines KW - V 22400:Human Diseases KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808613127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Assessing+the+impact+of+a+nurse-delivered+home+dried+blood+spot+service+on+uptake+of+testing+for+household+contacts+of+hepatitis+B-infected+pregnant+women+across+two+London+trusts&rft.au=Keel%2C+P%3BEdwards%2C+G%3BFlood%2C+J%3BNixon%2C+G%3BBeebeejaun%2C+K%3BShute%2C+J%3BPoh%2C+J%3BMillar%2C+A%3BIjaz%2C+S%3BParry%2C+J%3BMandal%2C+S%3BRamsay%2C+M%3BAmirthalingam%2C+G&rft.aulast=Keel&rft.aufirst=P&rft.date=2016-07-01&rft.volume=144&rft.issue=10&rft.spage=2087&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268815003325 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 9 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Blood; Age; Data processing; Hepatitis B; Vaccines; Vaccination; Pregnancy; Hepatitis; Intervention; Uptake; Females; Hepatitis B virus; British Isles, England, Greater London, London DO - http://dx.doi.org/10.1017/S0950268815003325 ER - TY - JOUR T1 - A meta-analysis of studies investigating the effects of occupational lead exposure on thyroid hormones AN - 1808611617; PQ0003269716 AB - Introduction Investigations of the effects of occupational exposure to lead on the concentrations of thyroid hormones in the blood have not produced consistent results. A meta-analysis was performed to assess the effect of occupational exposure to lead on thyroid hormone concentrations using the results from published studies. Methods Group means from studies of the thyroid function of persons occupationally exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between thyroid hormone concentrations and log sub(10) blood lead concentrations or duration of exposure to lead were estimated using mixed models. The hormones analyzed were thyroid stimulating hormone, total and free thyroxine, and total and free triiodothyronine. Results No differences in mean thyroid hormone concentrations were found between the exposed and control groups. No relationships were found between blood lead or the duration of exposure to lead and thyroid hormone concentrations. Conclusion The results of the analysis do not provide evidence for an effect of occupational lead exposure on thyroid function in men. Am. J. Ind. Med. 59:583-590, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Krieg, Edward F AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 583 EP - 590 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 7 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Thyroid KW - Triiodothyronine KW - Hormones KW - Lead KW - Blood levels KW - Models KW - Thyroid hormones KW - Blood KW - USA KW - Reviews KW - Thyroxine KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808611617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=A+meta-analysis+of+studies+investigating+the+effects+of+occupational+lead+exposure+on+thyroid+hormones&rft.au=Krieg%2C+Edward+F&rft.aulast=Krieg&rft.aufirst=Edward&rft.date=2016-07-01&rft.volume=59&rft.issue=7&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22591 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Blood; Thyroid hormones; Reviews; Thyroxine; Triiodothyronine; Occupational exposure; Lead; Models; Thyroid; Hormones; Blood levels; USA DO - http://dx.doi.org/10.1002/ajim.22591 ER - TY - JOUR T1 - Respirable indium exposures, plasma indium, and respiratory health among indium-tin oxide (ITO) workers AN - 1808610556; PQ0003269719 AB - Background Workers manufacturing indium-tin oxide (ITO) are at risk of elevated indium concentration in blood and indium lung disease, but relationships between respirable indium exposures and biomarkers of exposure and disease are unknown. Methods For 87 (93%) current ITO workers, we determined correlations between respirable and plasma indium and evaluated associations between exposures and health outcomes. Results Current respirable indium exposure ranged from 0.4 to 108 mu g/m super(3) and cumulative respirable indium exposure from 0.4 to 923 mu g-yr/m super(3). Plasma indium better correlated with cumulative (r sub(s)=0.77) than current exposure (r sub(s)=0.54) overall and with tenure greater than or equal to 1.9 years. Higher cumulative respirable indium exposures were associated with more dyspnea, lower spirometric parameters, and higher serum biomarkers of lung disease (KL-6 and SP-D), with significant effects starting at 22 mu g-yr/m super(3), reached by 46% of participants. Conclusions Plasma indium concentration reflected cumulative respirable indium exposure, which was associated with clinical, functional, and serum biomarkers of lung disease. Am. J. Ind. Med. 59:522-531, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Cummings, Kristin J AU - Virji, MAbbas AU - Park, Ji Young AU - Stanton, Marcia L AU - Edwards, Nicole T AU - Trapnell, Bruce C AU - Carey, Brenna AU - Stefaniak, Aleksandr B AU - Kreiss, Kathleen AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 522 EP - 531 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 7 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Bioindicators KW - Respiration KW - Lung diseases KW - biomarkers KW - Blood levels KW - Blood KW - Workers KW - USA KW - Lung KW - Indium KW - oxides KW - Dyspnea KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808610556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Respirable+indium+exposures%2C+plasma+indium%2C+and+respiratory+health+among+indium-tin+oxide+%28ITO%29+workers&rft.au=Cummings%2C+Kristin+J%3BVirji%2C+MAbbas%3BPark%2C+Ji+Young%3BStanton%2C+Marcia+L%3BEdwards%2C+Nicole+T%3BTrapnell%2C+Bruce+C%3BCarey%2C+Brenna%3BStefaniak%2C+Aleksandr+B%3BKreiss%2C+Kathleen&rft.aulast=Cummings&rft.aufirst=Kristin&rft.date=2016-07-01&rft.volume=59&rft.issue=7&rft.spage=522&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22585 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Workers; Respiration; Lung diseases; oxides; Dyspnea; biomarkers; Occupational exposure; Blood levels; Bioindicators; Blood; Lung; Indium; USA DO - http://dx.doi.org/10.1002/ajim.22585 ER - TY - JOUR T1 - Arsenic and Environmental Health: State of the Science and Future Research Opportunities. AN - 1808606878; 26587579 AB - Exposure to inorganic and organic arsenic compounds is a major public health problem that affects hundreds of millions of people worldwide. Exposure to arsenic is associated with cancer and noncancer effects in nearly every organ in the body, and evidence is mounting for health effects at lower levels of arsenic exposure than previously thought. Building from a tremendous knowledge base with > 1,000 scientific papers published annually with "arsenic" in the title, the question becomes, what questions would best drive future research directions? The objective is to discuss emerging issues in arsenic research and identify data gaps across disciplines. The National Institutes of Health's National Institute of Environmental Health Sciences Superfund Research Program convened a workshop to identify emerging issues and research needs to address the multi-faceted challenges related to arsenic and environmental health. This review summarizes information captured during the workshop. More information about aggregate exposure to arsenic is needed, including the amount and forms of arsenic found in foods. New strategies for mitigating arsenic exposures and related health effects range from engineered filtering systems to phytogenetics and nutritional interventions. Furthermore, integration of omics data with mechanistic and epidemiological data is a key step toward the goal of linking biomarkers of exposure and susceptibility to disease mechanisms and outcomes. Promising research strategies and technologies for arsenic exposure and adverse health effect mitigation are being pursued, and future research is moving toward deeper collaborations and integration of information across disciplines to address data gaps. Carlin DJ, Naujokas MF, Bradham KD, Cowden J, Heacock M, Henry HF, Lee JS, Thomas DJ, Thompson C, Tokar EJ, Waalkes MP, Birnbaum LS, Suk WA. 2016. Arsenic and environmental health: state of the science and future research opportunities. Environ Health Perspect 124:890-899; http://dx.doi.org/10.1289/ehp.1510209. JF - Environmental health perspectives AU - Carlin, Danielle J AU - Naujokas, Marisa F AU - Bradham, Karen D AU - Cowden, John AU - Heacock, Michelle AU - Henry, Heather F AU - Lee, Janice S AU - Thomas, David J AU - Thompson, Claudia AU - Tokar, Erik J AU - Waalkes, Michael P AU - Birnbaum, Linda S AU - Suk, William A AD - Superfund Research Program, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 890 EP - 899 VL - 124 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808606878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Arsenic+and+Environmental+Health%3A+State+of+the+Science+and+Future+Research+Opportunities.&rft.au=Carlin%2C+Danielle+J%3BNaujokas%2C+Marisa+F%3BBradham%2C+Karen+D%3BCowden%2C+John%3BHeacock%2C+Michelle%3BHenry%2C+Heather+F%3BLee%2C+Janice+S%3BThomas%2C+David+J%3BThompson%2C+Claudia%3BTokar%2C+Erik+J%3BWaalkes%2C+Michael+P%3BBirnbaum%2C+Linda+S%3BSuk%2C+William+A&rft.aulast=Carlin&rft.aufirst=Danielle&rft.date=2016-07-01&rft.volume=124&rft.issue=7&rft.spage=890&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1510209 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-08-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1510209 ER - TY - JOUR T1 - Evolution of strategies to improve preclinical cardiac safety testing. AN - 1801437099; 26893184 AB - The early and efficient assessment of cardiac safety liabilities is essential to confidently advance novel drug candidates. This article discusses evolving mechanistically based preclinical strategies for detecting drug-induced electrophysiological and structural cardiotoxicity using in vitro human ion channel assays, human-based in silico reconstructions and human stem cell-derived cardiomyocytes. These strategies represent a paradigm shift from current approaches, which rely on simplistic in vitro assays that measure blockade of the Kv11.1 current (also known as the hERG current or IKr) and on the use of non-human cells or tissues. These new strategies have the potential to improve sensitivity and specificity in the early detection of genuine cardiotoxicity risks, thereby reducing the likelihood of mistakenly discarding viable drug candidates and speeding the progression of worthy drugs into clinical trials. JF - Nature reviews. Drug discovery AU - Gintant, Gary AU - Sager, Philip T AU - Stockbridge, Norman AD - Department of Integrative Pharmacology, Integrated Science and Technology, AbbVie, Department ZR 13, Building AP9 01, 1 North Waukegan Road, North Chicago, Illinois 60064-6118, USA. ; Stanford University, 719 Carolina Street, San Francisco, California 94107, USA. ; Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 457 EP - 471 VL - 15 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1801437099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Nature+reviews.+Drug+discovery&rft.atitle=Evolution+of+strategies+to+improve+preclinical+cardiac+safety+testing.&rft.au=Gintant%2C+Gary%3BSager%2C+Philip+T%3BStockbridge%2C+Norman&rft.aulast=Gintant&rft.aufirst=Gary&rft.date=2016-07-01&rft.volume=15&rft.issue=7&rft.spage=457&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Drug+discovery&rft.issn=1474-1784&rft_id=info:doi/10.1038%2Fnrd.2015.34 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-30 N1 - Date revised - 2017-02-10 N1 - Last updated - 2017-02-10 DO - http://dx.doi.org/10.1038/nrd.2015.34 ER - TY - JOUR T1 - Inflammatory-Related Genetic Variants in Non-Muscle-Invasive Bladder Cancer Prognosis: A Multimarker Bayesian Assessment. AN - 1801434917; 27197286 AB - Increasing evidence points to the role of tumor immunologic environment on urothelial bladder cancer prognosis. This effect might be partly dependent on the host genetic context. We evaluated the association of SNPs in inflammation-related genes with non-muscle-invasive bladder cancer (NMIBC) risk-of-recurrence and risk-of-progression. We considered 822 NMIBC included in the SBC/EPICURO Study followed-up >10 years. We selected 1,679 SNPs belonging to 251 inflammatory genes. The association of SNPs with risk-of-recurrence and risk-of-progression was assessed using Cox regression single-marker (SMM) and multimarker methods (MMM) Bayes A and Bayesian LASSO. Discriminative abilities of the models were calculated using the c index and validated with bootstrap cross-validation procedures. While no SNP was found to be associated with risk-of-recurrence using SMM, three SNPs in TNIP1, CD5, and JAK3 showed very strong association with posterior probabilities >90% using MMM. Regarding risk-of-progression, one SNP in CD3G was significantly associated using SMM (HR, 2.69; P = 1.55 × 10(-5)) and two SNPs in MASP1 and AIRE, showed a posterior probability ≥80% with MMM. Validated discriminative abilities of the models without and with the SNPs were 58.4% versus 60.5% and 72.1% versus 72.8% for risk-of-recurrence and risk-of-progression, respectively. Using innovative analytic approaches, we demonstrated that SNPs in inflammatory-related genes were associated with NMIBC prognosis and that they improve the discriminative ability of prognostic clinical models for NMIBC. This study provides proof of concept for the joint effect of genetic variants in improving the discriminative ability of clinical prognostic models. The approach may be extended to other diseases. Cancer Epidemiol Biomarkers Prev; 25(7); 1144-50. ©2016 AACR. ©2016 American Association for Cancer Research. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Masson-Lecomte, Alexandra AU - López de Maturana, Evangelina AU - Goddard, Michael E AU - Picornell, Antoni AU - Rava, Marta AU - González-Neira, Anna AU - Márquez, Mirari AU - Carrato, Alfredo AU - Tardon, Adonina AU - Lloreta, Josep AU - Garcia-Closas, Montserrat AU - Silverman, Debra AU - Rothman, Nathaniel AU - Kogevinas, Manolis AU - Allory, Yves AU - Chanock, Stephen J AU - Real, Francisco X AU - Malats, Núria AU - SBC/EPICURO Study Investigators AD - Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Urology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, Créteil, France. ; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. ; Biosciences Research Division, Department of Environment and Primary Industries, Agribio, Bundoora, Victoria, Australia. Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Australia. ; Human Genotyping-CEGEN Unit, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. ; Servicio de Oncología, Hospital Universitario Ramon y Cajal, Madrid, and Servicio de Oncología, Hospital Universitario de Elche, Elche, Spain. ; Department of Preventive Medicine, Universidad de Oviedo, Oviedo, Spain. ; Institut Municipal d'Investigació Mèdica - Hospital del Mar and Departament de Patologia, Hospital del Mar - IMAS, Barcelona, Spain. ; Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland. ; Centre for Research in Environmental Epidemiology (CREAL) and Institut Municipal d'Investigació Mèdica - Hospital del Mar, Barcelona, Spain. ; Pathology Department, Henri Mondor Academic Hospital, Paris Est Créteil University, INSERM, Créteil, France. ; Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. ; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain. nmalats@cnio.es. ; SBC/EPICURO Study Investigators Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 1144 EP - 1150 VL - 25 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1801434917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Inflammatory-Related+Genetic+Variants+in+Non-Muscle-Invasive+Bladder+Cancer+Prognosis%3A+A+Multimarker+Bayesian+Assessment.&rft.au=Masson-Lecomte%2C+Alexandra%3BL%C3%B3pez+de+Maturana%2C+Evangelina%3BGoddard%2C+Michael+E%3BPicornell%2C+Antoni%3BRava%2C+Marta%3BGonz%C3%A1lez-Neira%2C+Anna%3BM%C3%A1rquez%2C+Mirari%3BCarrato%2C+Alfredo%3BTardon%2C+Adonina%3BLloreta%2C+Josep%3BGarcia-Closas%2C+Montserrat%3BSilverman%2C+Debra%3BRothman%2C+Nathaniel%3BKogevinas%2C+Manolis%3BAllory%2C+Yves%3BChanock%2C+Stephen+J%3BReal%2C+Francisco+X%3BMalats%2C+N%C3%BAria%3BSBC%2FEPICURO+Study+Investigators&rft.aulast=Masson-Lecomte&rft.aufirst=Alexandra&rft.date=2016-07-01&rft.volume=25&rft.issue=7&rft.spage=1144&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-15-0894 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1055-9965.EPI-15-0894 ER - TY - JOUR T1 - The Emergence of Systematic Review in Toxicology. AN - 1800703660; 27208075 AB - The Evidence-based Toxicology Collaboration hosted a workshop on "The Emergence of Systematic Review and Related Evidence-based Approaches in Toxicology," on November 21, 2014 in Baltimore, Maryland. The workshop featured speakers from agencies and organizations applying systematic review approaches to questions in toxicology, speakers with experience in conducting systematic reviews in medicine and healthcare, and stakeholders in industry, government, academia, and non-governmental organizations. Based on the workshop presentations and discussion, here we address the state of systematic review methods in toxicology, historical antecedents in both medicine and toxicology, challenges to the translation of systematic review from medicine to toxicology, and thoughts on the way forward. We conclude with a recommendation that as various agencies and organizations adapt systematic review methods, they continue to work together to ensure that there is a harmonized process for how the basic elements of systematic review methods are applied in toxicology. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Stephens, Martin L AU - Betts, Kellyn AU - Beck, Nancy B AU - Cogliano, Vincent AU - Dickersin, Kay AU - Fitzpatrick, Suzanne AU - Freeman, James AU - Gray, George AU - Hartung, Thomas AU - McPartland, Jennifer AU - Rooney, Andrew A AU - Scherer, Roberta W AU - Verloo, Didier AU - Hoffmann, Sebastian AD - Johns Hopkins Center for Alternatives to Animal Testing, Baltimore, Maryland msteph14@jhu.edu. ; Freelance Science and Technology Writer, Takoma Park, Maryland. ; American Chemistry Council, Washington, District of Columbia. ; US Environmental Protection Agency, Arlington, Virginia. ; Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland. ; Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland. ; ExxonMobil Biomedical Sciences, Annandale, New Jersey. ; George Washington University Milken Institute School of Public Health, Washington, DC. ; Johns Hopkins Center for Alternatives to Animal Testing, Baltimore, Maryland University of Konstanz, CAAT-Europe, Germany. ; Environmental Defense Fund, Washington, District of Columbia. ; Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina. ; European Food Safety Authority, Parma 43126, Italy. ; seh consulting + services, Paderborn 33098, Germany. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 10 EP - 16 VL - 152 IS - 1 KW - Index Medicus KW - risk of bias KW - data integration. KW - systematic review UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1800703660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=The+Emergence+of+Systematic+Review+in+Toxicology.&rft.au=Stephens%2C+Martin+L%3BBetts%2C+Kellyn%3BBeck%2C+Nancy+B%3BCogliano%2C+Vincent%3BDickersin%2C+Kay%3BFitzpatrick%2C+Suzanne%3BFreeman%2C+James%3BGray%2C+George%3BHartung%2C+Thomas%3BMcPartland%2C+Jennifer%3BRooney%2C+Andrew+A%3BScherer%2C+Roberta+W%3BVerloo%2C+Didier%3BHoffmann%2C+Sebastian&rft.aulast=Stephens&rft.aufirst=Martin&rft.date=2016-07-01&rft.volume=152&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw059 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw059 ER - TY - JOUR T1 - A Role for Regulatory T Cells in a Murine Model of Epicutaneous Toluene Diisocyanate Sensitization. AN - 1800703517; 27103660 AB - Toluene diisocyanate (TDI) is a leading cause of chemical-induced occupational asthma which impacts workers in a variety of industries worldwide. Recently, the robust regulatory potential of regulatory T cells (Tregs) has become apparent, including their functional role in the regulation of allergic disease; however, their function in TDI-induced sensitization has not been explored. To elucidate the kinetics, phenotype, and function of Tregs during TDI sensitization, BALB/c mice were dermally exposed (on each ear) to a single application of TDI (0.5-4% v/v) or acetone vehicle and endpoints were evaluated via RT-PCR and flow cytometry. The draining lymph node (dLN) Treg population expanded significantly 4, 7, and 9 days after single 4% TDI exposure. This population was identified using a variety of surface and intracellular markers and was found to be phenotypically heterogeneous based on increased expression of markers including CD103, CCR6, CTLA4, ICOS, and Neuropilin-1 during TDI sensitization. Tregs isolated from TDI-sensitized mice were significantly more suppressive compared with their control counterparts, further supporting a functional role for Tregs during TDI sensitization. Last, Tregs were depleted prior to TDI sensitization and an intensified sensitization response was observed. Collectively, these data indicate that Tregs exhibit a functional role during TDI sensitization. Because the role of Tregs in TDI sensitization has not been previously elucidated, these data contribute to the understanding of the immunologic mechanisms of chemical induced allergic disease. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. 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JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Long, Carrie Mae AU - Marshall, Nikki B AU - Lukomska, Ewa AU - Kashon, Michael L AU - Meade, B Jean AU - Shane, Hillary AU - Anderson, Stacey E AD - *Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 Immunology and Microbial Pathogenesis Graduate Program, West Virginia University School of Medicine, Morgantown, West Virginia 26505 cmlong@cdc.gov. ; *Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505. ; Biostatics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 85 EP - 98 VL - 152 IS - 1 KW - Index Medicus KW - hypersensitivity KW - regulatory T cells KW - chemical sensitization KW - TDI KW - isocyanate KW - chemical allergy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1800703517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=A+Role+for+Regulatory+T+Cells+in+a+Murine+Model+of+Epicutaneous+Toluene+Diisocyanate+Sensitization.&rft.au=Long%2C+Carrie+Mae%3BMarshall%2C+Nikki+B%3BLukomska%2C+Ewa%3BKashon%2C+Michael+L%3BMeade%2C+B+Jean%3BShane%2C+Hillary%3BAnderson%2C+Stacey+E&rft.aulast=Long&rft.aufirst=Carrie&rft.date=2016-07-01&rft.volume=152&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw074 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw074 ER - TY - JOUR T1 - Adverse neuropsychiatric effects of antimalarial drugs. AN - 1799559921; 27077782 AB - Antimalarial drugs are the primary weapon to treat parasite infection, save lives, and curtail further transmission. Accumulating data have indicated that at least some antimalarial drugs may contribute to severe neurological and/or psychiatric side effects which further complicates their use and limits the pool of available medications. In this review article, we summarize published scientific studies in search of evidence of the neuropsychiatric effects that may be attributed to the commonly used antimalarial drugs administered alone or in combination. Each individual drug was used as a search term in addition to keywords such as neuropsychiatric, adverse events, and neurotoxicity. Accumulating data based on published reports over several decades have suggested that among the major commonly used antimalarial drugs, only mefloquine exhibited clear indications of serious neurological and/or psychiatric side effects. A more systematic approach to assess the neuropsychiatric adverse effects of new or repurposed antimalarial drugs on their safety, tolerability and efficacy phases of clinical studies and in post-marketing surveillance, is needed to ensure that these life-saving tools remain available and can be prescribed with appropriate caution and medical judgment. JF - Expert opinion on drug safety AU - Grabias, Bryan AU - Kumar, Sanjai AD - a Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases , Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring , MD , USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 903 EP - 910 VL - 15 IS - 7 KW - Antimalarials KW - 0 KW - Mefloquine KW - TML814419R KW - Index Medicus KW - neurotoxicity KW - psychiatric adverse events KW - Mental Disorders -- chemically induced KW - Humans KW - Mefloquine -- therapeutic use KW - Mefloquine -- adverse effects KW - Malaria -- drug therapy KW - Neurotoxicity Syndromes -- etiology KW - Antimalarials -- adverse effects KW - Antimalarials -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1799559921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+safety&rft.atitle=Adverse+neuropsychiatric+effects+of+antimalarial+drugs.&rft.au=Grabias%2C+Bryan%3BKumar%2C+Sanjai&rft.aulast=Grabias&rft.aufirst=Bryan&rft.date=2016-07-01&rft.volume=15&rft.issue=7&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+safety&rft.issn=1744-764X&rft_id=info:doi/10.1080%2F14740338.2016.1175428 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-30 N1 - Date created - 2016-06-25 N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-01 DO - http://dx.doi.org/10.1080/14740338.2016.1175428 ER - TY - JOUR T1 - In Vivo Monitoring of Sevoflurane-induced Adverse Effects in Neonatal Nonhuman Primates Using Small-animal Positron Emission Tomography. AN - 1799204765; 27183169 AB - Animals exposed to sevoflurane during development sustain neuronal cell death in their developing brains. In vivo micro-positron emission tomography (PET)/computed tomography imaging has been utilized as a minimally invasive method to detect anesthetic-induced neuronal adverse effects in animal studies. Neonatal rhesus monkeys (postnatal day 5 or 6, 3 to 6 per group) were exposed for 8 h to 2.5% sevoflurane with or without acetyl-L-carnitine (ALC). Control monkeys were exposed to room air with or without ALC. Physiologic status was monitored throughout exposures. Depth of anesthesia was monitored using quantitative electroencephalography. After the exposure, microPET/computed tomography scans using F-labeled fluoroethoxybenzyl-N-(4-phenoxypyridin-3-yl) acetamide (FEPPA) were performed repeatedly on day 1, 1 and 3 weeks, and 2 and 6 months after exposure. Critical physiologic metrics in neonatal monkeys remained within the normal range during anesthetic exposures. The uptake of [F]-FEPPA in the frontal and temporal lobes was increased significantly 1 day or 1 week after exposure, respectively. Analyses of microPET images recorded 1 day after exposure showed that sevoflurane exposure increased [F]-FEPPA uptake in the frontal lobe from 0.927 ± 0.04 to 1.146 ± 0.04, and in the temporal lobe from 0.859 ± 0.05 to 1.046 ± 0.04 (mean ± SE, P < 0.05). Coadministration of ALC effectively blocked the increase in FEPPA uptake. Sevoflurane-induced adverse effects were confirmed by histopathologic evidence as well. Sevoflurane-induced general anesthesia during development increases glial activation, which may serve as a surrogate for neurotoxicity in the nonhuman primate brain. ALC is a potential protective agent against some of the adverse effects associated with such exposures. JF - Anesthesiology AU - Zhang, Xuan AU - Liu, Shuliang AU - Newport, Glenn D AU - Paule, Merle G AU - Callicott, Ralph AU - Thompson, James AU - Liu, Fang AU - Patterson, Tucker A AU - Berridge, Marc S AU - Apana, Scott M AU - Brown, Christina C AU - Maisha, Mackean P AU - Hanig, Joseph P AU - Slikker, William AU - Wang, Cheng AD - From the Divisions of Neurotoxicology (X.Z., S.L., G.D.N., M.G.P., F.L., T.A.P., C.W.) and Bioinformatics and Biostatistics (M.P.M.) and Priority One Services (R.C., J.T.), National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas; 3D Imaging, LLC, Little Rock, Arkansas (M.S.B., S.M.A., C.C.B.); and Center for Drug Evaluation and Research/U.S. Food and Drug Administration, Silver Spring, Maryland (J.P.H., W.S.). Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 133 EP - 146 VL - 125 IS - 1 KW - Abridged Index Medicus KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1799204765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anesthesiology&rft.atitle=In+Vivo+Monitoring+of+Sevoflurane-induced+Adverse+Effects+in+Neonatal+Nonhuman+Primates+Using+Small-animal+Positron+Emission+Tomography.&rft.au=Zhang%2C+Xuan%3BLiu%2C+Shuliang%3BNewport%2C+Glenn+D%3BPaule%2C+Merle+G%3BCallicott%2C+Ralph%3BThompson%2C+James%3BLiu%2C+Fang%3BPatterson%2C+Tucker+A%3BBerridge%2C+Marc+S%3BApana%2C+Scott+M%3BBrown%2C+Christina+C%3BMaisha%2C+Mackean+P%3BHanig%2C+Joseph+P%3BSlikker%2C+William%3BWang%2C+Cheng&rft.aulast=Zhang&rft.aufirst=Xuan&rft.date=2016-07-01&rft.volume=125&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Anesthesiology&rft.issn=1528-1175&rft_id=info:doi/10.1097%2FALN.0000000000001154 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/ALN.0000000000001154 ER - TY - JOUR T1 - The Effects of Pharmaceutical Excipients on Gastrointestinal Tract Metabolic Enzymes and Transporters-an Update. AN - 1798993013; 27184579 AB - Accumulating evidence from the last decade has shown that many pharmaceutical excipients are not pharmacologically inert but instead have effects on metabolic enzymes and/or drug transporters. Hence, the absorption, distribution, metabolism, and elimination (ADME) of active pharmaceutical ingredients (APIs) may be altered due to the modulation of their metabolism and transport by excipients. The impact of excipients is a potential concern for Biopharmaceutics Classification System (BCS)-based biowaivers, particularly as the BCS-based biowaivers have been extended to class 3 drugs in certain dosage forms. The presence of different excipients or varying amounts of excipients between formulations may result in bio-inequivalence. The excipient impact may lead to significant variations in clinical outcomes as well. The aim of this paper is to review the recent findings of excipient effects on gastrointestinal (GI) absorption, focusing on their interactions with the metabolic enzymes and transporters in the GI tract. A wide range of commonly used excipients such as binders, diluents, fillers, solvents, and surfactants are discussed here. We summarized the reported effects of those excipients on GI tract phase I and phase II enzymes, uptake and efflux transporters, and relevant clinical significance. This information can enhance our understanding of excipient influence on drug absorption and is useful in designing pharmacokinetic studies and evaluating the resultant data. JF - The AAPS journal AU - Zhang, Wenpeng AU - Li, Yanyan AU - Zou, Peng AU - Wu, Man AU - Zhang, Zhenqing AU - Zhang, Tao AD - State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China. ; School of Science and Humanities, Husson University, Bangor, Maine, USA. ; CDER/OPQ, Food and Drug Administration (FDA), Silver Springs, Maryland, USA. ; Department of Basic Pharmaceutical Sciences, School of Pharmacy, Husson University, Bangor, Maine, USA. zhangt@husson.edu. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 830 EP - 843 VL - 18 IS - 4 KW - Excipients KW - 0 KW - Membrane Transport Proteins KW - Pharmaceutical Preparations KW - Index Medicus KW - transporter KW - metabolic enzyme KW - absorption KW - pharmacokinetics KW - pharmaceutical excipient KW - Chemistry, Pharmaceutical KW - Humans KW - Gastrointestinal Tract -- metabolism KW - Biopharmaceutics -- classification KW - Excipients -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798993013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=The+Effects+of+Pharmaceutical+Excipients+on+Gastrointestinal+Tract+Metabolic+Enzymes+and+Transporters-an+Update.&rft.au=Zhang%2C+Wenpeng%3BLi%2C+Yanyan%3BZou%2C+Peng%3BWu%2C+Man%3BZhang%2C+Zhenqing%3BZhang%2C+Tao&rft.aulast=Zhang&rft.aufirst=Wenpeng&rft.date=2016-07-01&rft.volume=18&rft.issue=4&rft.spage=830&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-016-9928-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-31 N1 - Date created - 2016-06-21 N1 - Date revised - 2017-02-02 N1 - SuppNotes - Comment On: Eur J Pharm Sci. 2009 Mar 2;36(4-5):401-11 [19041719] Mol Pharm. 2013 Jul 1;10(7):2739-48 [23701529] Pharm Res. 2010 Aug;27(8):1703-12 [20503067] Eur J Pharm Biopharm. 2010 Oct;76(2):260-8 [20600890] Eur J Pharm Sci. 2013 Nov 20;50(3-4):429-39 [23981337] Iran J Pharm Res. 2013 Winter;12(Suppl):37-46 [24250670] Mol Pharm. 2014 Jan 6;11(1):71-80 [24256068] Int J Pharm. 2011 May 16;409(1-2):164-8 [21382460] Mol Pharm. 2008 Sep-Oct;5(5):863-75 [18651749] Drug Metab Dispos. 2007 Jul;35(7):1142-8 [17446265] N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1208/s12248-016-9928-8 ER - TY - JOUR T1 - The FDA's Experience with Emerging Genomics Technologies-Past, Present, and Future. AN - 1798992938; 27116022 AB - The rapid advancement of emerging genomics technologies and their application for assessing safety and efficacy of FDA-regulated products require a high standard of reliability and robustness supporting regulatory decision-making in the FDA. To facilitate the regulatory application, the FDA implemented a novel data submission program, Voluntary Genomics Data Submission (VGDS), and also to engage the stakeholders. As part of the endeavor, for the past 10 years, the FDA has led an international consortium of regulatory agencies, academia, pharmaceutical companies, and genomics platform providers, which was named MicroArray Quality Control Consortium (MAQC), to address issues such as reproducibility, precision, specificity/sensitivity, and data interpretation. Three projects have been completed so far assessing these genomics technologies: gene expression microarrays, whole genome genotyping arrays, and whole transcriptome sequencing (i.e., RNA-seq). The resultant studies provide the basic parameters for fit-for-purpose application of these new data streams in regulatory environments, and the solutions have been made available to the public through peer-reviewed publications. The latest MAQC project is also called the SEquencing Quality Control (SEQC) project focused on next-generation sequencing. Using reference samples with built-in controls, SEQC studies have demonstrated that relative gene expression can be measured accurately and reliably across laboratories and RNA-seq platforms. Besides prediction performance comparable to microarrays in clinical settings and safety assessments, RNA-seq is shown to have better sensitivity for low expression and reveal novel transcriptomic features. Future effort of MAQC will be focused on quality control of whole genome sequencing and targeted sequencing. JF - The AAPS journal AU - Xu, Joshua AU - Thakkar, Shraddha AU - Gong, Binsheng AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. Weida.tong@fda.hhs.gov. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 814 EP - 818 VL - 18 IS - 4 KW - Index Medicus KW - next-generation sequencing KW - RNA-seq KW - reproducibility KW - genomics KW - big data KW - United States KW - Gene Expression Profiling KW - Humans KW - Sequence Analysis, RNA KW - Quality Control KW - High-Throughput Nucleotide Sequencing KW - United States Food and Drug Administration KW - Genomics -- legislation & jurisprudence KW - Microarray Analysis -- standards KW - Genomics -- ethics KW - Genomics -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798992938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=The+FDA%27s+Experience+with+Emerging+Genomics+Technologies-Past%2C+Present%2C+and+Future.&rft.au=Xu%2C+Joshua%3BThakkar%2C+Shraddha%3BGong%2C+Binsheng%3BTong%2C+Weida&rft.aulast=Xu&rft.aufirst=Joshua&rft.date=2016-07-01&rft.volume=18&rft.issue=4&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-016-9917-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-14 N1 - Date created - 2016-06-21 N1 - Date revised - 2017-02-16 N1 - Last updated - 2017-02-16 DO - http://dx.doi.org/10.1208/s12248-016-9917-y ER - TY - JOUR T1 - Linking MedDRA(®)-Coded Clinical Phenotypes to Biological Mechanisms by the Ontology of Adverse Events: A Pilot Study on Tyrosine Kinase Inhibitors. AN - 1798723243; 27003817 AB - A translational bioinformatics challenge exists in connecting population and individual clinical phenotypes in various formats to biological mechanisms. The Medical Dictionary for Regulatory Activities (MedDRA(®)) is the default dictionary for adverse event (AE) reporting in the US Food and Drug Administration Adverse Event Reporting System (FAERS). The ontology of adverse events (OAE) represents AEs as pathological processes occurring after drug exposures. The aim of this work was to establish a semantic framework to link biological mechanisms to phenotypes of AEs by combining OAE with MedDRA(®) in FAERS data analysis. We investigated the AEs associated with tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs) targeting tyrosine kinases. The five selected TKIs/mAbs (i.e., dasatinib, imatinib, lapatinib, cetuximab, and trastuzumab) are known to induce impaired ventricular function (non-QT) cardiotoxicity. Statistical analysis of FAERS data identified 1053 distinct MedDRA(®) terms significantly associated with TKIs/mAbs, where 884 did not have corresponding OAE terms. We manually annotated these terms, added them to OAE by the standard OAE development strategy, and mapped them to MedDRA(®). The data integration to provide insights into molecular mechanisms of drug-associated AEs was performed by including linkages in OAE for all related AE terms to MedDRA(®) and the existing ontologies, including the human phenotype ontology (HP), Uber anatomy ontology (UBERON), and gene ontology (GO). Sixteen AEs were shared by all five TKIs/mAbs, and each of 17 cardiotoxicity AEs was associated with at least one TKI/mAb. As an example, we analyzed "cardiac failure" using the relations established in OAE with other ontologies and demonstrated that one of the biological processes associated with cardiac failure maps to the genes associated with heart contraction. By expanding the existing OAE ontological design, our TKI use case demonstrated that the combination of OAE and MedDRA(®) provides a semantic framework to link clinical phenotypes of adverse drug events to biological mechanisms. JF - Drug safety AU - Sarntivijai, Sirarat AU - Zhang, Shelley AU - Jagannathan, Desikan G AU - Zaman, Shadia AU - Burkhart, Keith K AU - Omenn, Gilbert S AU - He, Yongqun AU - Athey, Brian D AU - Abernethy, Darrell R AD - Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. siiraa@umich.edu. ; College of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI, USA. ; College of Engineering, University of Michigan, Ann Arbor, MI, USA. ; Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. ; Department of Internal Medicine and Human Genetics and School of Public Health, University of Michigan, Ann Arbor, MI, USA. ; Unit of Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, USA. ; Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 697 EP - 707 VL - 39 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798723243?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Linking+MedDRA%28%C2%AE%29-Coded+Clinical+Phenotypes+to+Biological+Mechanisms+by+the+Ontology+of+Adverse+Events%3A+A+Pilot+Study+on+Tyrosine+Kinase+Inhibitors.&rft.au=Sarntivijai%2C+Sirarat%3BZhang%2C+Shelley%3BJagannathan%2C+Desikan+G%3BZaman%2C+Shadia%3BBurkhart%2C+Keith+K%3BOmenn%2C+Gilbert+S%3BHe%2C+Yongqun%3BAthey%2C+Brian+D%3BAbernethy%2C+Darrell+R&rft.aulast=Sarntivijai&rft.aufirst=Sirarat&rft.date=2016-07-01&rft.volume=39&rft.issue=7&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=1179-1942&rft_id=info:doi/10.1007%2Fs40264-016-0414-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s40264-016-0414-0 ER - TY - JOUR T1 - Metal binding mediated conformational change of XPA protein:a potential cytotoxic mechanism of nickel in the nucleotide excision repair. AN - 1797878272; 27307058 AB - Nucleotide excision repair (NER) is a pivotal life process for repairing DNA nucleotide mismatch caused by chemicals, metal ions, radiation, and other factors. As the initiation step of NER, the xeroderma pigmentosum complementation group A protein (XPA) recognizes damaged DNA molecules, and recruits the replication protein A (RPA), another important player in the NER process. The stability of the Zn(2+)-chelated Zn-finger domain of XPA center core portion (i.e., XPA98-210) is the foundation of its biological functionality, while the displacement of the Zn(2+) by toxic metal ions (such as Ni(2+), a known human carcinogen and allergen) may impair the effectiveness of NER and hence elevate the chance of carcinogenesis. In this study, we first calculated the force field parameters for the bonded model in the metal center of the XPA98-210 system, showing that the calculated results, including charges, bonds, angles etc., are congruent with previously reported results measured by spectrometry experiments and quantum chemistry computation. Then, comparative molecular dynamics simulations using these parameters revealed the changes in the conformation and motion mode of XPA98-210 Zn-finger after the substitution of Zn(2+) by Ni(2+). The results showed that Ni(2+) dramatically disrupted the relative positions of the four Cys residues in the Zn-finger structure, forcing them to collapse from a tetrahedron into an almost planar structure. Finally, we acquired the binding mode of XPA98-210 with its ligands RPA70N and DNA based on molecular docking and structural alignment. We found that XPA98-210's Zn-finger domain primarily binds to a V-shaped cleft in RPA70N, while the cationic band in its C-terminal subdomain participates in the recognition of damaged DNA. In addition, this article sheds light on the multi-component interaction pattern among XPA, DNA, and other NER-related proteins (i.e., RPA70N, RPA70A, RPA70B, RPA70C, RPA32, and RPA14) based on previously reported structural biology information. Thus, we derived a putative cytotoxic mechanism associated with the nickel ion, where the Ni(2+) disrupts the conformation of the XPA Zn-finger, directly weakening its interaction with RPA70N, and thus lowering the effectiveness of the NER process. In sum, this work not only provides a theoretical insight into the multi-protein interactions involved in the NER process and potential cytotoxic mechanism associated with Ni(2+) binding in XPA, but may also facilitate rational anti-cancer drug design based on the NER mechanism. JF - Journal of molecular modeling AU - Hu, Jianping AU - Hu, Ziheng AU - Zhang, Yan AU - Gou, Xiaojun AU - Mu, Ying AU - Wang, Lirong AU - Xie, Xiang-Qun AD - College of Chemistry, Leshan Normal University, Leshan, Sichuan, 614004, China. ; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; NIH National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Department of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA. ; School of Pharmacy and Bioengineering; Key Laboratory of Medicinal and Edible Plants Resources Development, School of Bioengineering, Chengdu University, Chengdu, Sichuan, 610106, China. ; Division of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA. ; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; NIH National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Department of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA. liw30@pitt.edu. ; Department of Pharmaceutical Sciences and Computational Chemical Genomics Screening Center, School of Pharmacy; NIH National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Department of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15260, USA. xix15@pitt.edu. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 156 VL - 22 IS - 7 KW - Index Medicus KW - XPA KW - Cytotoxic mechanism KW - Nucleotide excision repair KW - Nickel ion KW - Zn-finger UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797878272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+modeling&rft.atitle=Metal+binding+mediated+conformational+change+of+XPA+protein%3Aa+potential+cytotoxic+mechanism+of+nickel+in+the+nucleotide+excision+repair.&rft.au=Hu%2C+Jianping%3BHu%2C+Ziheng%3BZhang%2C+Yan%3BGou%2C+Xiaojun%3BMu%2C+Ying%3BWang%2C+Lirong%3BXie%2C+Xiang-Qun&rft.aulast=Hu&rft.aufirst=Jianping&rft.date=2016-07-01&rft.volume=22&rft.issue=7&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+modeling&rft.issn=0948-5023&rft_id=info:doi/10.1007%2Fs00894-016-3017-x LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-16 N1 - Date revised - 2017-02-06 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1007/s00894-016-3017-x ER - TY - JOUR T1 - Virulence Gene Profiles and Clonal Relationships of Escherichia coli O26:H11 Isolates from Feedlot Cattle as Determined by Whole-Genome Sequencing. AN - 1797229107; 27107118 AB - Escherichia coli O26 is the second most important enterohemorrhagic E. coli (EHEC) serogroup worldwide. Serogroup O26 strains are categorized mainly into two groups: enteropathogenic (EPEC) O26, carrying a locus of enterocyte effacement (LEE) and mostly causing mild diarrhea, and Shiga-toxigenic (STEC) O26, which carries the Shiga toxin (STX) gene (stx), responsible for more severe outcomes. stx-negative O26 strains can be further split into two groups. One O26 group differs significantly from O26 EHEC, while the other O26 EHEC-like group shows all the characteristics of EHEC O26 except production of STX. In order to determine the different populations of O26 E. coli present in U.S. cattle, we sequenced 42 O26:H11 strains isolated from feedlot cattle and compared them to 37 O26:H11 genomes available in GenBank. Phylogenetic analysis by whole-genome multilocus sequence typing (wgMLST) showed that O26:H11/H(-) strains in U.S. cattle were highly diverse. Most strains were sequence type 29 (ST29). By wgMLST, two clear lineages could be distinguished among cattle strains. Lineage 1 consisted of O26:H11 EHEC-like strains (ST29) (4 strains) and O26:H11 EHEC strains (ST21) (2 strains), and lineage 2 (36 strains) consisted of O26:H11 EPEC strains (ST29). Overall, our analysis showed U.S. cattle carried pathogenic (ST21; stx1 (+) ehxA(+) toxB(+)) and also potentially pathogenic (ST29; ehxA(+) toxB(+)) O26:H11 E. coli strains. Furthermore, in silico analysis showed that 70% of the cattle strains carried at least one antimicrobial resistance gene. Our results showed that whole-genome sequence analysis is a robust and valid approach to identify and genetically characterize E. coli O26:H11, which is of importance for food safety and public health. Escherichia coli O26 is the second most important type of enterohemorrhagic E. coli (EHEC) worldwide. Serogroup O26 strains are categorized into two groups: enteropathogenic (EPEC) carrying LEE, causing mild diarrhea, and Shiga toxigenic (STEC) carrying the stx gene, responsible for more severe outcomes. However, there are currently problems in distinguishing one group from the other. Furthermore, several O26 stx-negative strains are consistently misidentified as either EHEC-like or EPEC. The use of whole-genome sequence (WGS) analysis of O26 strains from cattle in the United States (i) allowed identification of O26 strains present in U.S. cattle, (ii) determined O26 strain diversity, (iii) solved the misidentification problem, and (iv) screened for the presence of antimicrobial resistance and virulence genes in the strains. This study provided a framework showing how to easily and rapidly use WGS information to identify and genetically characterize E. coli O26:H11, which is important for food safety and public health. Copyright © 2016, American Society for Microbiology. All Rights Reserved. JF - Applied and environmental microbiology AU - Gonzalez-Escalona, Narjol AU - Toro, Magaly AU - Rump, Lydia V AU - Cao, Guojie AU - Nagaraja, T G AU - Meng, Jianghong AD - Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA narjol.gonzalez-escalona@fda.hhs.gov. ; Instituto de Nutricion y Tecnologia de los Alimentos, Universidad de Chile, Santiago, Chile. ; Joint Institute for Food Safety and Applied Nutrition and Department of Nutrition and Food Science, University of Maryland, College Park, Maryland, USA. ; Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA. Y1 - 2016/07/01/ PY - 2016 DA - 2016 Jul 01 SP - 3900 EP - 3912 VL - 82 IS - 13 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1797229107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Virulence+Gene+Profiles+and+Clonal+Relationships+of+Escherichia+coli+O26%3AH11+Isolates+from+Feedlot+Cattle+as+Determined+by+Whole-Genome+Sequencing.&rft.au=Gonzalez-Escalona%2C+Narjol%3BToro%2C+Magaly%3BRump%2C+Lydia+V%3BCao%2C+Guojie%3BNagaraja%2C+T+G%3BMeng%2C+Jianghong&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2016-07-01&rft.volume=82&rft.issue=13&rft.spage=3900&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.00498-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/AEM.00498-16 ER - TY - JOUR T1 - Using GRADE to respond to health questions with different levels of urgency. AN - 1795870654; 27126781 AB - Increasing interest exists in applying the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to environmental health evidence. While ideally applied to evidence synthesized in systematic reviews and corresponding summary tables, such as evidence profiles, GRADE's correct application requires that "the evidence that was assessed and the methods that were used to identify and appraise that evidence should be clearly described." In this article, we suggest that GRADE could be applied to evidence assembled from narrative reviews, modelled (indirect) evidence, or evidence assembled as part of a rapid response, if the underlying judgments about the certainty in this evidence are based on the relevant GRADE domains and provided transparently. Health questions that require assessing the certainty in a body of evidence to provide trustworthy answers may range from hours, to days or weeks, to a few months to scenarios that allow assessing evidence without short-term time pressures. Time frames of emergent, urgent or rapid evidence assessments will often require relying on existing summaries or rapidly compiling the available evidence and making assessments. Even without available full systematic reviews, expressing the certainty in the evidence can provide useful guidance for users of the evidence and those who evaluate certainty in effects. The ratings also help clarifying disagreement between organizations tackling similar questions about the evidence. Using the structured GRADE domains, narrative or other summaries of the evidence can be presented transparently. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Environment international AU - Thayer, Kristina A AU - Schünemann, Holger J AD - Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA. Electronic address: thayer@niehs.nih.gov. ; Department of Clinical Epidemiology & Biostatistics, Department of Medicine, McMaster University, Health Sciences Centre, Room 2C14, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address: schuneh@mcmaster.ca. PY - 2016 SP - 585 EP - 589 VL - 92-93 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795870654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Using+GRADE+to+respond+to+health+questions+with+different+levels+of+urgency.&rft.au=Thayer%2C+Kristina+A%3BSch%C3%BCnemann%2C+Holger+J&rft.aulast=Thayer&rft.aufirst=Kristina&rft.date=2016-07-01&rft.volume=92-93&rft.issue=&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.03.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2016.03.027 ER - TY - JOUR T1 - Effects of iron oxide nanoparticles on biological responses and MR imaging properties in human mammary healthy and breast cancer epithelial cells. AN - 1795867941; 26013845 AB - Superparamagnetic iron oxide nanoparticles (SPIONs, diameters >50 nm) have received great attention due to their promising use as magnetic resonance imaging (MRI) contrast agents. In this study, we evaluated the cellular uptake and biological responses in vitro of ultrasmall SPIONs (USPIONs, diameters < 50 nm). We compared the cellular responses between breast epithelia isolated from healthy and breast cancer donors after exposure to carboxy-terminated USPIONs (10 and 30 nm PEG-coated, 10 and 30 nm non-PEG-coated). The particles were characterized using transmission electron microscopy (TEM), dynamic light scattering (DLS) and gel electrophoresis. Cellular interactions with USPIONs were assessed by confocal microscopy and TEM. Cellular uptake of USPIONs was quantified using ICP-MS. Cell viability was measured by MTT and neutral red uptake assays. T2* weighted MRI scans were performed using a 7T scanner. Results demonstrated that cell association/internalization of USPIONs was size- and surface coating-dependent (PEG vs. non-PEG), and higher cellular uptake of 10 and 30 nm non-coated particles was observed in both cell types compared with PEG-coated particles. Cell uptake for 10 and 30 nm non-coated particles was higher in cancer cells from two of three tested donors compared to healthy cells from three donors. There was no significant cytotoxicity observed for all tested particles. Significantly enhanced MRI contrast was observed following exposure to 10 and 30 nm non-coated particles compared to PEG-coated particles in both cell types. In comparison, cancer cells showed more enhanced MRI signals when compared to normal cells. The data indicate that cell responses following exposure to USPIONs are dependent on particle properties. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1032-1042, 2016. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of biomedical materials research. Part B, Applied biomaterials AU - Zhang, Qin AU - Rajan, Sunder S AU - Tyner, Katherine M AU - Casey, Brendan J AU - Dugard, Christopher K AU - Jones, Yvonne AU - Paredes, Angel M AU - Clingman, Chekesha S AU - Howard, Paul C AU - Goering, Peter L AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland, 20993. ; Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, 20993. ; Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, 72079. ; Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, 20993. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 1032 EP - 1042 VL - 104 IS - 5 KW - Index Medicus KW - breast epithelial cells KW - magnetic resonance imaging KW - contrast agents KW - iron oxide KW - nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795867941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomedical+materials+research.+Part+B%2C+Applied+biomaterials&rft.atitle=Effects+of+iron+oxide+nanoparticles+on+biological+responses+and+MR+imaging+properties+in+human+mammary+healthy+and+breast+cancer+epithelial+cells.&rft.au=Zhang%2C+Qin%3BRajan%2C+Sunder+S%3BTyner%2C+Katherine+M%3BCasey%2C+Brendan+J%3BDugard%2C+Christopher+K%3BJones%2C+Yvonne%3BParedes%2C+Angel+M%3BClingman%2C+Chekesha+S%3BHoward%2C+Paul+C%3BGoering%2C+Peter+L&rft.aulast=Zhang&rft.aufirst=Qin&rft.date=2016-07-01&rft.volume=104&rft.issue=5&rft.spage=1032&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomedical+materials+research.+Part+B%2C+Applied+biomaterials&rft.issn=1552-4981&rft_id=info:doi/10.1002%2Fjbm.b.33450 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jbm.b.33450 ER - TY - JOUR T1 - Implementing systematic review techniques in chemical risk assessment: Challenges, opportunities and recommendations. AN - 1795867832; 26687863 AB - Systematic review (SR) is a rigorous, protocol-driven approach designed to minimise error and bias when summarising the body of research evidence relevant to a specific scientific question. Taking as a comparator the use of SR in synthesising research in healthcare, we argue that SR methods could also pave the way for a "step change" in the transparency, objectivity and communication of chemical risk assessments (CRA) in Europe and elsewhere. We suggest that current controversies around the safety of certain chemicals are partly due to limitations in current CRA procedures which have contributed to ambiguity about the health risks posed by these substances. We present an overview of how SR methods can be applied to the assessment of risks from chemicals, and indicate how challenges in adapting SR methods from healthcare research to the CRA context might be overcome. Regarding the latter, we report the outcomes from a workshop exploring how to increase uptake of SR methods, attended by experts representing a wide range of fields related to chemical toxicology, risk analysis and SR. Priorities which were identified include: the conduct of CRA-focused prototype SRs; the development of a recognised standard of reporting and conduct for SRs in toxicology and CRA; and establishing a network to facilitate research, communication and training in SR methods. We see this paper as a milestone in the creation of a research climate that fosters communication between experts in CRA and SR and facilitates wider uptake of SR methods into CRA. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved. JF - Environment international AU - Whaley, Paul AU - Halsall, Crispin AU - Ågerstrand, Marlene AU - Aiassa, Elisa AU - Benford, Diane AU - Bilotta, Gary AU - Coggon, David AU - Collins, Chris AU - Dempsey, Ciara AU - Duarte-Davidson, Raquel AU - FitzGerald, Rex AU - Galay-Burgos, Malyka AU - Gee, David AU - Hoffmann, Sebastian AU - Lam, Juleen AU - Lasserson, Toby AU - Levy, Len AU - Lipworth, Steven AU - Ross, Sarah Mackenzie AU - Martin, Olwenn AU - Meads, Catherine AU - Meyer-Baron, Monika AU - Miller, James AU - Pease, Camilla AU - Rooney, Andrew AU - Sapiets, Alison AU - Stewart, Gavin AU - Taylor, David AD - Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK. ; Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK. Electronic address: c.halsall@lancaster.ac.uk. ; Department of Environmental Science and Analytical Chemistry, Stockholm University, SE-106 91, Stockholm, Sweden. ; Assessment and Methodological Support Unit, European Food Safety Authority, Via Carlo Magno 1/a 43126, Parma, Italy. ; Food Standards Agency, Aviation House, 125 Kingsway, London WC2B 6NH, UK. ; Aquatic Research Centre, University of Brighton, Lewes Road, Brighton BN2 4GJ, UK. ; MRC Lifecourse Epidemiology Unit, University of Southampton, MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK. ; Department of Geography and Environmental Science, School of Archaeology, Geography and Environmental Science, University of Reading, Reading, RG6 6DW, United Kingdom. ; Royal Society of Chemistry, Burlington House, Piccadilly, London W1J 0BA, UK. ; Centre for Radiation, Chemicals and Environmental Hazards, Public Health England, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0RQ, UK. ; Swiss Centre for Applied Human Toxicology, University of Basel, Missionsstrasse 64, 4055 Basel, Switzerland. ; European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), Avenue Edmond Van Nieuwenhuyse 2 Bte 8B-1160 Brussels, Belgium. ; Institute for the Environment, Health and Societies, Brunel University London, Kingston Lane, Uxbridge UB8 3PH, UK. ; Evidence-Based Toxicology Collaboration (EBTC), Stembergring 15, 33106 Paderborn, Germany. ; University of California San Francisco, Program on Reproductive Health and the Environment, San Francisco, CA, USA. ; Cochrane Editorial Unit, Cochrane Central Executive, St Albans House, 57-9 Haymarket, London SW1Y 4QX, UK. ; Institute of Environment, Health, Risks and Futures, School of Energy, Environment and Agrifood, Cranfield University, Cranfield, Bedfordshire MK43 0AL, UK. ; Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London WC1E 6BT, UK. ; Health Economics Research Group, Brunel University London, Kingston Lane, Uxbridge UB8 3PH, UK. ; Leibniz Research Centre for Working Environment and Human Factors (IfADo), Neurobehavioural Toxicology, Ardeystr 67, D-44139 Dortmund, Germany. ; Centre for Ecology and Hydrology, Wallingford, Oxfordshire 0X10 8BB, UK. ; Ramboll Environ, 1 Broad Gate, The Headrow, Leeds LS1 8EQ, UK. ; National Institute of Environmental Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, NC, USA. ; Syngenta Ltd., Jealott's Hill International Research Centre, Bracknell RG42 6EY, UK. ; Centre for Rural Economy, School of Agriculture, Food and Rural Development, University of Newcastle upon Tyne, UK. PY - 2016 SP - 556 EP - 564 VL - 92-93 KW - Index Medicus KW - Risk assessment KW - Environment KW - Chemicals KW - Research synthesis KW - Systematic review KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795867832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Implementing+systematic+review+techniques+in+chemical+risk+assessment%3A+Challenges%2C+opportunities+and+recommendations.&rft.au=Whaley%2C+Paul%3BHalsall%2C+Crispin%3B%C3%85gerstrand%2C+Marlene%3BAiassa%2C+Elisa%3BBenford%2C+Diane%3BBilotta%2C+Gary%3BCoggon%2C+David%3BCollins%2C+Chris%3BDempsey%2C+Ciara%3BDuarte-Davidson%2C+Raquel%3BFitzGerald%2C+Rex%3BGalay-Burgos%2C+Malyka%3BGee%2C+David%3BHoffmann%2C+Sebastian%3BLam%2C+Juleen%3BLasserson%2C+Toby%3BLevy%2C+Len%3BLipworth%2C+Steven%3BRoss%2C+Sarah+Mackenzie%3BMartin%2C+Olwenn%3BMeads%2C+Catherine%3BMeyer-Baron%2C+Monika%3BMiller%2C+James%3BPease%2C+Camilla%3BRooney%2C+Andrew%3BSapiets%2C+Alison%3BStewart%2C+Gavin%3BTaylor%2C+David&rft.aulast=Whaley&rft.aufirst=Paul&rft.date=2016-07-01&rft.volume=92-93&rft.issue=&rft.spage=556&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2015.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2015.11.002 ER - TY - JOUR T1 - Safe use of high intakes of folic acid: research challenges and paths forward. AN - 1795867829; 27272334 AB - Adequate folic acid intake is an effective dietary-based prevention tool for reducing the risk of neural tube defects. Achieving adequate intake for the prevention of neural tube defects frequently requires the consumption of foods fortified with folic acid and/or the use of folic acid-containing dietary supplements. To date, research on the potential for adverse effects of high intakes of folic acid has been limited. Without such research, it is difficult to define a value for high intake. In May 2015, an expert panel was tasked with examining the available scientific literature and making research recommendations within 4 general categories of potential folate-related adverse health effects: cancer, cognition in conjunction with vitamin B12 deficiency, hypersensitivity-related outcomes, and thyroid and diabetes-related disorders. This article summarizes the expert panel's conclusions, outlines the challenges faced when reviewing the literature, and examines some of the panel's recommendations for research. Published by Oxford University Press on behalf of the International Life Sciences Institute 2016. This work is written by US Government employees and is in the public domain in the United States. JF - Nutrition reviews AU - Boyles, Abee L AU - Yetley, Elizabeth A AU - Thayer, Kristina A AU - Coates, Paul M AD - A.L. Boyles and K.A. Thayer are with the Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA. E.A. Yetley and P.M. Coates are with the Office of Dietary Supplements, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. abee.boyles@nih.gov. ; A.L. Boyles and K.A. Thayer are with the Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina, USA. E.A. Yetley and P.M. Coates are with the Office of Dietary Supplements, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 469 EP - 474 VL - 74 IS - 7 KW - Index Medicus KW - folic acid KW - research recommendations KW - high vitamin intake KW - safety. UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795867829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nutrition+reviews&rft.atitle=Safe+use+of+high+intakes+of+folic+acid%3A+research+challenges+and+paths+forward.&rft.au=Boyles%2C+Abee+L%3BYetley%2C+Elizabeth+A%3BThayer%2C+Kristina+A%3BCoates%2C+Paul+M&rft.aulast=Boyles&rft.aufirst=Abee&rft.date=2016-07-01&rft.volume=74&rft.issue=7&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Nutrition+reviews&rft.issn=1753-4887&rft_id=info:doi/10.1093%2Fnutrit%2Fnuw015 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Erratum In: Nutr Rev. 2016 Sep;74(9):600 [27353599] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/nutrit/nuw015 ER - TY - JOUR T1 - GRADE: Assessing the quality of evidence in environmental and occupational health. AN - 1795867290; 26827182 AB - There is high demand in environmental health for adoption of a structured process that evaluates and integrates evidence while making decisions and recommendations transparent. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework holds promise to address this demand. For over a decade, GRADE has been applied successfully to areas of clinical medicine, public health, and health policy, but experience with GRADE in environmental and occupational health is just beginning. Environmental and occupational health questions focus on understanding whether an exposure is a potential health hazard or risk, assessing the exposure to understand the extent and magnitude of risk, and exploring interventions to mitigate exposure or risk. Although GRADE offers many advantages, including its flexibility and methodological rigor, there are features of the different sources of evidence used in environmental and occupational health that will require further consideration to assess the need for method refinement. An issue that requires particular attention is the evaluation and integration of evidence from human, animal, in vitro, and in silico (computer modeling) studies when determining whether an environmental factor represents a potential health hazard or risk. Assessment of the hazard of exposures can produce analyses for use in the GRADE evidence-to-decision (EtD) framework to inform risk-management decisions about removing harmful exposures or mitigating risks. The EtD framework allows for grading the strength of the recommendations based on judgments of the certainty in the evidence (also known as quality of the evidence), as well as other factors that inform recommendations such as social values and preferences, resource implications, and benefits. GRADE represents an untapped opportunity for environmental and occupational health to make evidence-based recommendations in a systematic and transparent manner. The objectives of this article are to provide an overview of GRADE, discuss GRADE's applicability to environmental health, and identify priority areas for method assessment and development. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Environment international AU - Morgan, Rebecca L AU - Thayer, Kristina A AU - Bero, Lisa AU - Bruce, Nigel AU - Falck-Ytter, Yngve AU - Ghersi, Davina AU - Guyatt, Gordon AU - Hooijmans, Carlijn AU - Langendam, Miranda AU - Mandrioli, Daniele AU - Mustafa, Reem A AU - Rehfuess, Eva A AU - Rooney, Andrew A AU - Shea, Beverley AU - Silbergeld, Ellen K AU - Sutton, Patrice AU - Wolfe, Mary S AU - Woodruff, Tracey J AU - Verbeek, Jos H AU - Holloway, Alison C AU - Santesso, Nancy AU - Schünemann, Holger J AD - Department of Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Centre, Room 2C14, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address: morganrl@mcmaster.ca. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA. Electronic address: thayer@niehs.nih.gov. ; Charles Perkins Centre, The University of Sydney, D17, The Hub, 6th floor, New South Wales, 2006, Australia. Electronic address: lisa.bero@sydney.edu.au. ; Department of Public Health and Policy, University of Liverpool, L69 3GB, United Kingdom. Electronic address: ngb@liv.ac.uk. ; Division of Gastroenterology, Case Western Reserve University and Louis Stokes VA Medical Center, 10701 East Blvd., Cleveland, OH 44106, USA. Electronic address: Yngve.Falck-Ytter@case.edu. ; Sydney Medical School, University of Sydney, New South Wales 2006, Australia; National Health and Medical Research Council, 16 Marcus Clarke Street, Canberra City, ACT 2601, Australia. Electronic address: davina.ghersi@nhmrc.gov.au. ; Department of Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Centre, Room 2C14, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address: guyatt@mcmaster.ca. ; Departments of SYRCLE and Anesthesiology, Radboud University Medical Centre, Geert Grooteplein-Noord 29, Route 231, 6525 GA Nijmegen, The Netherlands. Electronic address: Carlijn.Hooijmans@radboudumc.nl. ; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Room J1B-211, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. Electronic address: m.w.langendam@amc.uva.nl. ; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Via Saliceto 3, Bentivoglio, Bologna, P.O. Box 40133, Italy. Electronic address: mandriolid@ramazzini.it. ; Department of Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Centre, Room 2C14, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada; Departments of Medicine/Nephrology and Biomedical & Health Informatics, University of Missouri-Kansas City, School of Medicine, M4-303, 2411 Holmes St., Kansas City, Missouri 64108-2792, USA. Electronic address: ramustafa@gmail.com. ; Institute for Medical Informatics, Biometry and Epidemiology, University of Munich, Marchioninistr. 15, 81377 Munich, Germany. Electronic address: rehfuess@ibe.med.uni-muenchen.de. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA. Electronic address: andrew.rooney@nih.gov. ; Bruyere Research Institute and Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada. Electronic address: bevshea@uottawa.ca. ; Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, E6644, Baltimore, MD 21205, USA. Electronic address: esilber2@jhu.edu. ; Program on Reproductive Health and the Environment, University of California-San Francisco, 550 16th Street, San Francisco, CA 94143, USA. Electronic address: patrice.sutton@ucsf.edu. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA. Electronic address: wolfe@niehs.nih.gov. ; Program on Reproductive Health and the Environment, University of California-San Francisco, 550 16th Street, San Francisco, CA 94143, USA. Electronic address: tracey.woodrfuff@ucsf.edu. ; Finnish Institute of Occupational Health, Cochrane Work, PO Box 310, 70101 Kuopio, Finland. Electronic address: Jos.Verbeek@ttl.fi. ; Department of Obstetrics and Gynecology, McMaster University, Health Sciences Centre, Room 3N52A, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address: hollow@mcmaster.ca. ; Department of Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Centre, Room 2C14, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address: santesna@mcmaster.ca. ; Department of Clinical Epidemiology & Biostatistics, McMaster University, Health Sciences Centre, Room 2C14, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada; Department of Medicine, McMaster University, Health Sciences Centre, Room 2C14, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada. Electronic address: schuneha@mcmaster.ca. PY - 2016 SP - 611 EP - 616 VL - 92-93 KW - Index Medicus KW - Risk assessment KW - GRADE KW - Evidence-based KW - Risk of bias KW - Environmental health KW - Recommendations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795867290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=GRADE%3A+Assessing+the+quality+of+evidence+in+environmental+and+occupational+health.&rft.au=Morgan%2C+Rebecca+L%3BThayer%2C+Kristina+A%3BBero%2C+Lisa%3BBruce%2C+Nigel%3BFalck-Ytter%2C+Yngve%3BGhersi%2C+Davina%3BGuyatt%2C+Gordon%3BHooijmans%2C+Carlijn%3BLangendam%2C+Miranda%3BMandrioli%2C+Daniele%3BMustafa%2C+Reem+A%3BRehfuess%2C+Eva+A%3BRooney%2C+Andrew+A%3BShea%2C+Beverley%3BSilbergeld%2C+Ellen+K%3BSutton%2C+Patrice%3BWolfe%2C+Mary+S%3BWoodruff%2C+Tracey+J%3BVerbeek%2C+Jos+H%3BHolloway%2C+Alison+C%3BSantesso%2C+Nancy%3BSch%C3%BCnemann%2C+Holger+J&rft.aulast=Morgan&rft.aufirst=Rebecca&rft.date=2016-07-01&rft.volume=92-93&rft.issue=&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.01.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2016.01.004 ER - TY - JOUR T1 - Dosing recommendations for pharmacogenetic interactions related to drug metabolism. AN - 1793904920; 27058883 AB - OBJECTIVE Pharmacogenomic studies have established the important contribution of drug-metabolizing enzyme genotype toward drug toxicity and treatment failure; however, clinical implementation of pharmacogenomics has been slow. The aim of this study was to systematically review the information on drug-metabolizing enzyme pharmacogenomics available in the US drug labeling, practice guidelines, and recommendations. METHODS Drug-metabolizing enzyme genotype and phenotype information was assessed in US FDA drug labeling, clinical practice guidelines, and independent technology assessors to evaluate the consistency in information sources for healthcare providers. RESULTS Eighty four gene-drug pairs were identified as having drug-metabolizing enzyme genotype or phenotype information within the label. The manner in which pharmacogenomic information was presented was heterogeneous both within the label and between clinical practice recommendations. CONCLUSION For proper implementation of pharmacogenomics in clinical practice, information sources for healthcare providers should relay consistent and clear information for the appropriate use of biomarkers. JF - Pharmacogenetics and genomics AU - Filipski, Kelly K AU - Pacanowski, Michael A AU - Ramamoorthy, Anuradha AU - Feero, William Gregory AU - Freedman, Andrew N AD - aEpidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville bOffice of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland cMaine Dartmouth Family Medicine Residency Program, Augusta, Maine, USA. Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 334 EP - 339 VL - 26 IS - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793904920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Dosing+recommendations+for+pharmacogenetic+interactions+related+to+drug+metabolism.&rft.au=Filipski%2C+Kelly+K%3BPacanowski%2C+Michael+A%3BRamamoorthy%2C+Anuradha%3BFeero%2C+William+Gregory%3BFreedman%2C+Andrew+N&rft.aulast=Filipski&rft.aufirst=Kelly&rft.date=2016-07-01&rft.volume=26&rft.issue=7&rft.spage=334&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=1744-6880&rft_id=info:doi/10.1097%2FFPC.0000000000000220 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-04 N1 - Date revised - 2017-02-17 N1 - Last updated - 2017-02-17 DO - http://dx.doi.org/10.1097/FPC.0000000000000220 ER - TY - JOUR T1 - Interactions of Staphylococcus aureus with ultrasoft hydrogel biomaterials AN - 1790962984; PQ0003064611 AB - Ultrasoft biomaterials-polymers, gels, and human soft tissues with an elastic modulus less than 100 kPa-are increasingly used in medical devices. While bacterial interactions (adhesion and biofilm formation) have been extensively studied on stiffer materials, little is known about how bacteria colonize ultrasoft materials as a nidus for infection. The goal of this work was to determine how material properties of ultrasoft hydrogels used for dermal fillers might affect pathogenesis of associated infections. We first synthesized a range of polyacrylamide hydrogels (PAAm) with moduli similar to clinically used dermal fillers and characterized the rheological, morphological and porous properties. We then developed a novel microfabricated insert to contain the PAAm in a flow system for quantification of bacterial adhesion and biofilm formation. The rate of adhesion and numbers of adherent Staphylococcus aureus on the surface of PAAm both decreased as the modulus increased. Adhesion was reduced by 3 logs (from 93 104/cm2 to 0.083 104/cm2) with increasing modulus (from 17 Pa to 654 Pa). However, the number of bacteria in the bulk was the highest within the stiffest gels. This trend was further amplified in subsequent biofilm studies, where interfacial coverage of biofilm decreased as the modulus increased, while the fraction of biofilm in the bulk was the highest within the stiffest gel. The results show significant differences in bacterial colonization of PAAm based on material properties, and reveal how the injection process may unexpectedly create discontinuities that provide a microenvironmental niche for bacterial colonization. JF - Biomaterials AU - Wang, Yi AU - Guan, Allan AU - Isayeva, Irada AU - Vorvolakos, Katherine AU - Das, Srilekha AU - Li, Zhenyu AU - Phillips, KScott AD - United States Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry and Materials Science, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA Y1 - 2016/07// PY - 2016 DA - July 2016 SP - 74 EP - 85 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 95 SN - 0142-9612, 0142-9612 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Hydrogel KW - Medical device KW - Biofilm KW - Infection KW - Bacteria KW - Plastic surgery KW - Colonization KW - Skin KW - hydrogels KW - Niches KW - Biomaterials KW - Biofilms KW - Staphylococcus aureus KW - Soft tissues KW - Mechanical properties KW - J 02320:Cell Biology KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790962984?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Interactions+of+Staphylococcus+aureus+with+ultrasoft+hydrogel+biomaterials&rft.au=Wang%2C+Yi%3BGuan%2C+Allan%3BIsayeva%2C+Irada%3BVorvolakos%2C+Katherine%3BDas%2C+Srilekha%3BLi%2C+Zhenyu%3BPhillips%2C+KScott&rft.aulast=Wang&rft.aufirst=Yi&rft.date=2016-07-01&rft.volume=95&rft.issue=&rft.spage=74&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2016.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Colonization; Skin; hydrogels; Niches; Biomaterials; Biofilms; Infection; Soft tissues; Mechanical properties; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.biomaterials.2016.04.005 ER - TY - JOUR T1 - Iron overload by Superparamagnetic Iron Oxide Nanoparticles is a High Risk Factor in Cirrhosis by a Systems Toxicology Assessment. AN - 1801434067; 27357559 AB - Superparamagnetic iron oxide nanoparticles (SPIONs) as a contrast agent have been widely used in magnetic resonance imaging for tumor diagnosis and theranostics. However, there has been safety concern of SPIONs with cirrhosis related to excess iron-induced oxidative stress. In this study, the impact of iron overload by SPIONs was assessed on a mouse cirrhosis model. A single dose of SPION injection at 0.5 or 5 mg Fe/kg in the cirrhosis group induced a septic shock response at 24 h with elevated serum levels of liver and kidney function markers and extended impacts over 14 days including high levels of serum cholesterols and persistent low serum iron level. In contrast, full restoration of liver functions was found in the normal group with the same dosages over time. Analysis with PCR array of the toxicity pathways revealed the high dose of SPIONs induced significant expression changes of a distinct subset of genes in the cirrhosis liver. All these results suggested that excess iron of the high dose of SPIONs might be a risk factor for cirrhosis because of the marked impacts of elevated lipid metabolism, disruption of iron homeostasis and possibly, aggravated loss of liver functions. JF - Scientific reports AU - Wei, Yushuang AU - Zhao, Mengzhu AU - Yang, Fang AU - Mao, Yang AU - Xie, Hang AU - Zhou, Qibing AD - Department of Nanomedicine &Biopharmaceuticals, National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, Hubei, China. ; Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, United States of America. Y1 - 2016/06/30/ PY - 2016 DA - 2016 Jun 30 SP - 29110 VL - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1801434067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Iron+overload+by+Superparamagnetic+Iron+Oxide+Nanoparticles+is+a+High+Risk+Factor+in+Cirrhosis+by+a+Systems+Toxicology+Assessment.&rft.au=Wei%2C+Yushuang%3BZhao%2C+Mengzhu%3BYang%2C+Fang%3BMao%2C+Yang%3BXie%2C+Hang%3BZhou%2C+Qibing&rft.aulast=Wei&rft.aufirst=Yushuang&rft.date=2016-06-30&rft.volume=6&rft.issue=&rft.spage=29110&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep29110 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep29110 ER - TY - JOUR T1 - The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity. AN - 1789044995; 27113703 AB - Amiodarone is a widely used potent antiarrhythmic for the treatment of cardiac disease; however, its use is often discontinued due to numerous adverse effects, including hepatotoxicity. To investigate the role of drug metabolism in this liver toxicity, amiodarone and its major metabolite desethylamiodarone were incubated with HepG2 cells overexpressing a series of cytochrome P450 (CYP) isoforms. Significantly higher cytotoxicity of amiodarone was observed in HepG2 cells overexpressing CYP3A4 or CYP1A1, compared with that observed in empty vector transduced control cells. Further, higher levels of the more potent hepatotoxic metabolite desethylamiodarone were detected in CYP3A4 or CYP1A1 expressed cells. The CYP3A4 inhibitor ketoconazole and the CYP1A1 inhibitor α-naphthoflavone drastically inhibited the metabolism of amiodarone to desethylamiodarone. Along with the inhibition of CYP1A1 or CYP3A4, the cytotoxicity of amiodarone was significantly reduced. These data indicate that the metabolism of amiodarone to desethylamiodarone by CYP1A1 or CYP3A4 plays an important role in the hepatocellular toxicity of amiodarone. JF - Toxicology letters AU - Wu, Qiangen AU - Ning, Baitang AU - Xuan, Jiekun AU - Ren, Zhen AU - Guo, Lei AU - Bryant, Matthew S AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of System Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Lei.Guo@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Matthew.Bryant@fda.hhs.gov. Y1 - 2016/06/24/ PY - 2016 DA - 2016 Jun 24 SP - 55 EP - 62 VL - 253 KW - Anti-Arrhythmia Agents KW - 0 KW - Benzoflavones KW - Cytochrome P-450 CYP3A Inhibitors KW - alpha-naphthoflavone KW - 604-59-1 KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - CYP1A1 protein, human KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP3A KW - desethylamiodarone KW - M31FU99E3Y KW - Amiodarone KW - N3RQ532IUT KW - Ketoconazole KW - R9400W927I KW - Index Medicus KW - Amiodarone metabolism KW - HepG2 expressing CYP KW - HepG2 cells KW - Cytochrome P450s (CYPs) KW - Desethylamiodarone KW - Hep G2 Cells KW - Cell Survival -- drug effects KW - Transfection KW - Dose-Response Relationship, Drug KW - Humans KW - Cytochrome P-450 CYP3A Inhibitors -- pharmacology KW - Activation, Metabolic KW - Time Factors KW - Ketoconazole -- pharmacology KW - Benzoflavones -- pharmacology KW - Hepatocytes -- drug effects KW - Cytochrome P-450 CYP1A1 -- genetics KW - Anti-Arrhythmia Agents -- toxicity KW - Chemical and Drug Induced Liver Injury -- pathology KW - Chemical and Drug Induced Liver Injury -- genetics KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Hepatocytes -- pathology KW - Cytochrome P-450 CYP3A -- genetics KW - Hepatocytes -- enzymology KW - Cytochrome P-450 CYP1A1 -- antagonists & inhibitors KW - Amiodarone -- toxicity KW - Chemical and Drug Induced Liver Injury -- enzymology KW - Amiodarone -- metabolism KW - Chemical and Drug Induced Liver Injury -- etiology KW - Amiodarone -- analogs & derivatives KW - Cytochrome P-450 CYP3A -- metabolism KW - Anti-Arrhythmia Agents -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789044995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=The+role+of+CYP+3A4+and+1A1+in+amiodarone-induced+hepatocellular+toxicity.&rft.au=Wu%2C+Qiangen%3BNing%2C+Baitang%3BXuan%2C+Jiekun%3BRen%2C+Zhen%3BGuo%2C+Lei%3BBryant%2C+Matthew+S&rft.aulast=Wu&rft.aufirst=Qiangen&rft.date=2016-06-24&rft.volume=253&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2016.04.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-03 N1 - Date created - 2016-05-13 N1 - Date revised - 2017-02-07 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.1016/j.toxlet.2016.04.016 ER - TY - JOUR T1 - Multivariate Statistical Analysis of Cigarette Design Feature Influence on ISO TNCO Yields. AN - 1798723680; 27222918 AB - The aim of this study is to explore how differences in cigarette physical design parameters influence tar, nicotine, and carbon monoxide (TNCO) yields in mainstream smoke (MSS) using the International Organization of Standardization (ISO) smoking regimen. Standardized smoking methods were used to evaluate 50 U.S. domestic brand cigarettes and a reference cigarette representing a range of TNCO yields in MSS collected from linear smoking machines using a nonintense smoking regimen. Multivariate statistical methods were used to form clusters of cigarettes based on their ISO TNCO yields and then to explore the relationship between the ISO generated TNCO yields and the nine cigarette physical design parameters between and within each cluster simultaneously. The ISO generated TNCO yields in MSS are 1.1-17.0 mg tar/cigarette, 0.1-2.2 mg nicotine/cigarette, and 1.6-17.3 mg CO/cigarette. Cluster analysis divided the 51 cigarettes into five discrete clusters based on their ISO TNCO yields. No one physical parameter dominated across all clusters. Predicting ISO machine generated TNCO yields based on these nine physical design parameters is complex due to the correlation among and between the nine physical design parameters and TNCO yields. From these analyses, it is estimated that approximately 20% of the variability in the ISO generated TNCO yields comes from other parameters (e.g., filter material, filter type, inclusion of expanded or reconstituted tobacco, and tobacco blend composition, along with differences in tobacco leaf origin and stalk positions and added ingredients). A future article will examine the influence of these physical design parameters on TNCO yields under a Canadian Intense (CI) smoking regimen. Together, these papers will provide a more robust picture of the design features that contribute to TNCO exposure across the range of real world smoking patterns. JF - Chemical research in toxicology AU - Agnew-Heard, Kimberly A AU - Lancaster, Vicki A AU - Bravo, Roberto AU - Watson, Clifford AU - Walters, Matthew J AU - Holman, Matthew R AD - Center for Tobacco Products, U.S. Food and Drug Administration , 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, United States. ; National Center for Environmental Health, Centers For Disease Control and Prevention , 4770 Buford Highway, NE, Atlanta, Georgia 30341, United States. Y1 - 2016/06/20/ PY - 2016 DA - 2016 Jun 20 SP - 1051 EP - 1063 VL - 29 IS - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798723680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Multivariate+Statistical+Analysis+of+Cigarette+Design+Feature+Influence+on+ISO+TNCO+Yields.&rft.au=Agnew-Heard%2C+Kimberly+A%3BLancaster%2C+Vicki+A%3BBravo%2C+Roberto%3BWatson%2C+Clifford%3BWalters%2C+Matthew+J%3BHolman%2C+Matthew+R&rft.aulast=Agnew-Heard&rft.aufirst=Kimberly&rft.date=2016-06-20&rft.volume=29&rft.issue=6&rft.spage=1051&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00096 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00096 ER - TY - JOUR T1 - Unkinking the Lewis and Clark tectonic zone, Belt Basin, Idaho and Montana AN - 1828850241; 2016-087181 AB - A succession of separate tectonic events affected Mesoproterozoic Belt Supergroup strata of NW Montana, just as in the better-displayed Coeur d'Alene Mining District of Idaho. A series of these established a tectonic zone historically known as the Lewis and Clark line, here re-identified as the Lewis and Clark tectonic zone, an apparent product of periodic reactivation of fundamental basement structures and physical constraint of a growth fault on developing folds. Six events identify a partial tectonic history of the west-central Belt Basin. The oldest produced growth faults concentrated along at least two structural lineaments, one of which, the Jocko line, substantially controlled the distribution of subsequent structures; the other, the north-trending Noxon line, is implicated in creation of metal-enriched source rock for Coeur d'Alene veins and provides a marker for right-lateral faulting within the Lewis and Clark tectonic zone. Subsequent deformation produced (1) west-northwest-trending folds, mostly confined to the Lewis and Clark tectonic zone and terminating northward against the Jocko line as the likely result of their having been compressed against this pre-Belt Basin structure; (2) north-trending regional folds, which extend southward from Canada and cross the ultimate Lewis and Clark tectonic zone; (3) foliated shear zones in the Lewis and Clark tectonic zone and associated Coeur d'Alene veins and reverse faults; (4) right-lateral, transcurrent faults, so identified by offsets of the Noxon line, north-trending regional folds, and the Montana overthrust belt and its associated foredeep basin; and, last, (5) Lewis and Clark tectonic zone normal faults and associated kink folds, which extensively reached gigantic, "megakink" proportions. These megakinks locally disrupted all prior structures, greatly confusing local structure; these need to be "unkinked," so that structures resulting from prior tectonism may be fully recognized and correctly interpreted. Many faults of the Lewis and Clark tectonic zone trend southeasterly in its easterly part, tracking pre-Belt Basin structures separate from those associated with the Jocko line. JF - Special Paper - Geological Society of America AU - White, Brian G Y1 - 2016/06/16/ PY - 2016 DA - 2016 Jun 16 SP - SPE522 EP - 13 PB - Geological Society of America (GSA), Boulder, CO VL - 522 SN - 0072-1077, 0072-1077 KW - United States KW - North America KW - Idaho KW - shear zones KW - Noxon Line KW - upper Precambrian KW - Precambrian KW - stereographic projection KW - structural analysis KW - Lewis and Clark Lineament KW - Jocko Line KW - Proterozoic KW - Belt Basin KW - preferred orientation KW - Montana KW - Mesoproterozoic KW - Coeur d'Alene mining district KW - folds KW - foliation KW - tectonics KW - faults KW - 16:Structural geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1828850241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Special+Paper+-+Geological+Society+of+America&rft.atitle=Unkinking+the+Lewis+and+Clark+tectonic+zone%2C+Belt+Basin%2C+Idaho+and+Montana&rft.au=White%2C+Brian+G&rft.aulast=White&rft.aufirst=Brian&rft.date=2016-06-16&rft.volume=522&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Special+Paper+-+Geological+Society+of+America&rft.issn=00721077&rft_id=info:doi/10.1130%2F2016.2522%2813%29 L2 - http://specialpapers.gsapubs.org/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2016-01-01 N1 - Number of references - 50 N1 - PubXState - CO N1 - Document feature - illus. incl. sketch map N1 - SuppNotes - Online First N1 - Last updated - 2016-10-25 N1 - CODEN - GSAPAZ N1 - SubjectsTermNotLitGenreText - Belt Basin; Coeur d'Alene mining district; faults; folds; foliation; Idaho; Jocko Line; Lewis and Clark Lineament; Mesoproterozoic; Montana; North America; Noxon Line; Precambrian; preferred orientation; Proterozoic; shear zones; stereographic projection; structural analysis; tectonics; United States; upper Precambrian DO - http://dx.doi.org/10.1130/2016.2522(13) ER - TY - JOUR T1 - Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome. AN - 1796682733; 27291797 AB - To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) and detected 124 mosaic X events >2 Mb in 97 (0.25%) women. Here we show rates for X-chromosome mosaicism are four times higher than mean autosomal rates; X mosaic events more often include the entire chromosome and participants with X events more likely harbour autosomal mosaic events. X mosaicism frequency increases with age (0.11% in 50-year olds; 0.45% in 75-year olds), as reported for Y and autosomes. Methylation array analyses of 33 women with X mosaicism indicate events preferentially involve the inactive X chromosome. Our results provide further evidence that the sex chromosomes undergo mosaic events more frequently than autosomes, which could have implications for understanding the underlying mechanisms of mosaic events and their possible contribution to risk for chronic diseases. JF - Nature communications AU - Machiela, Mitchell J AU - Zhou, Weiyin AU - Karlins, Eric AU - Sampson, Joshua N AU - Freedman, Neal D AU - Yang, Qi AU - Hicks, Belynda AU - Dagnall, Casey AU - Hautman, Christopher AU - Jacobs, Kevin B AU - Abnet, Christian C AU - Aldrich, Melinda C AU - Amos, Christopher AU - Amundadottir, Laufey T AU - Arslan, Alan A AU - Beane-Freeman, Laura E AU - Berndt, Sonja I AU - Black, Amanda AU - Blot, William J AU - Bock, Cathryn H AU - Bracci, Paige M AU - Brinton, Louise A AU - Bueno-de-Mesquita, H Bas AU - Burdett, Laurie AU - Buring, Julie E AU - Butler, Mary A AU - Canzian, Federico AU - Carreón, Tania AU - Chaffee, Kari G AU - Chang, I-Shou AU - Chatterjee, Nilanjan AU - Chen, Chu AU - Chen, Constance AU - Chen, Kexin AU - Chung, Charles C AU - Cook, Linda S AU - Crous Bou, Marta AU - Cullen, Michael AU - Davis, Faith G AU - De Vivo, Immaculata AU - Ding, Ti AU - Doherty, Jennifer AU - Duell, Eric J AU - Epstein, Caroline G AU - Fan, Jin-Hu AU - Figueroa, Jonine D AU - Fraumeni, Joseph F AU - Friedenreich, Christine M AU - Fuchs, Charles S AU - Gallinger, Steven AU - Gao, Yu-Tang AU - Gapstur, Susan M AU - Garcia-Closas, Montserrat AU - Gaudet, Mia M AU - Gaziano, J Michael AU - Giles, Graham G AU - Gillanders, Elizabeth M AU - Giovannucci, Edward L AU - Goldin, Lynn AU - Goldstein, Alisa M AU - Haiman, Christopher A AU - Hallmans, Goran AU - Hankinson, Susan E AU - Harris, Curtis C AU - Henriksson, Roger AU - Holly, Elizabeth A AU - Hong, Yun-Chul AU - Hoover, Robert N AU - Hsiung, Chao A AU - Hu, Nan AU - Hu, Wei AU - Hunter, David J AU - Hutchinson, Amy AU - Jenab, Mazda AU - Johansen, Christoffer AU - Khaw, Kay-Tee AU - Kim, Hee Nam AU - Kim, Yeul Hong AU - Kim, Young Tae AU - Klein, Alison P AU - Klein, Robert AU - Koh, Woon-Puay AU - Kolonel, Laurence N AU - Kooperberg, Charles AU - Kraft, Peter AU - Krogh, Vittorio AU - Kurtz, Robert C AU - LaCroix, Andrea AU - Lan, Qing AU - Landi, Maria Teresa AU - Marchand, Loic Le AU - Li, Donghui AU - Liang, Xiaolin AU - Liao, Linda M AU - Lin, Dongxin AU - Liu, Jianjun AU - Lissowska, Jolanta AU - Lu, Lingeng AU - Magliocco, Anthony M AU - Malats, Nuria AU - Matsuo, Keitaro AU - McNeill, Lorna H AU - McWilliams, Robert R AU - Melin, Beatrice S AU - Mirabello, Lisa AU - Moore, Lee AU - Olson, Sara H AU - Orlow, Irene AU - Park, Jae Yong AU - Patiño-Garcia, Ana AU - Peplonska, Beata AU - Peters, Ulrike AU - Petersen, Gloria M AU - Pooler, Loreall AU - Prescott, Jennifer AU - Prokunina-Olsson, Ludmila AU - Purdue, Mark P AU - Qiao, You-Lin AU - Rajaraman, Preetha AU - Real, Francisco X AU - Riboli, Elio AU - Risch, Harvey A AU - Rodriguez-Santiago, Benjamin AU - Ruder, Avima M AU - Savage, Sharon A AU - Schumacher, Fredrick AU - Schwartz, Ann G AU - Schwartz, Kendra L AU - Seow, Adeline AU - Wendy Setiawan, Veronica AU - Severi, Gianluca AU - Shen, Hongbing AU - Sheng, Xin AU - Shin, Min-Ho AU - Shu, Xiao-Ou AU - Silverman, Debra T AU - Spitz, Margaret R AU - Stevens, Victoria L AU - Stolzenberg-Solomon, Rachael AU - Stram, Daniel AU - Tang, Ze-Zhong AU - Taylor, Philip R AU - Teras, Lauren R AU - Tobias, Geoffrey S AU - Van Den Berg, David AU - Visvanathan, Kala AU - Wacholder, Sholom AU - Wang, Jiu-Cun AU - Wang, Zhaoming AU - Wentzensen, Nicolas AU - Wheeler, William AU - White, Emily AU - Wiencke, John K AU - Wolpin, Brian M AU - Wong, Maria Pik AU - Wu, Chen AU - Wu, Tangchun AU - Wu, Xifeng AU - Wu, Yi-Long AU - Wunder, Jay S AU - Xia, Lucy AU - Yang, Hannah P AU - Yang, Pan-Chyr AU - Yu, Kai AU - Zanetti, Krista A AU - Zeleniuch-Jacquotte, Anne AU - Zheng, Wei AU - Zhou, Baosen AU - Ziegler, Regina G AU - Perez-Jurado, Luis A AU - Caporaso, Neil E AU - Rothman, Nathaniel AU - Tucker, Margaret AU - Dean, Michael C AU - Yeager, Meredith AU - Chanock, Stephen J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA. ; Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, Leidos Biomedical Research Inc., Bethesda, Maryland 20892, USA. ; Department of Thoracic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. ; Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ; Department of Obstetrics and Gynecology, New York University School of Medicine, New York, New York 10016, USA. ; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. ; Karmanos Cancer Institute and Department of Oncology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. ; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94143, USA. ; Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), 3721 Bilthoven, The Netherlands. ; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. ; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45226, USA. ; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. ; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA. ; National Institute of Cancer Research, National Health Research Institutes, Zhunan 35053, Taiwan. ; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. ; Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts 02115, USA. ; Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300040, China. ; University of New Mexico, Albuquerque, New Mexico 87131, USA. ; Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada T6G 2R3. ; Shanxi Cancer Hospital, Taiyuan, Shanxi 030013, China. ; Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire 03755, USA. ; Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology (ICO-IDIBELL), 08908 Barcelona, Spain. ; Shanghai Cancer Institute, Shanghai 200032, China. ; Department of Population Health Research, Cancer Control Alberta, Alberta Health Services, Calgary, Alberta, Canada T2N 2T9. ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. ; Fred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada M5G 1X5. ; Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotaong University School of Medicine, Shanghai 200032, China. ; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA. ; Division of Genetics and Epidemiology, and Breakthrough Breast Cancer Centre, Institute for Cancer Research, London SM2 5NG, UK. ; Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. ; Cancer Epidemiology Centre, Cancer Council Victoria &Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria 3010, Australia. ; Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892, USA. ; Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern California, Los Angeles, California 90033, USA. ; Department of Public Health and Clinical Medicine/Nutritional Research, Umeå University, 901 87 Umeå, Sweden. ; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. ; Department of Radiation Sciences, Oncology, Umeå University, 901 87 Umeå, Sweden. ; Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 151-742, Republic of Korea. ; Institute of Population Health Sciences, National Health Research Institutes, Zhunan 35053, Taiwan. ; International Agency for Research on Cancer (IARC-WHO), 69372 Lyon, France. ; Oncology, Finsen Centre, Rigshospitalet, 2100 Copenhagen, Denmark. ; School of Clinical Medicine, University of Cambridge, Cambridge CB2 1TN, UK. ; Center for Creative Biomedical Scientists, Chonnam National University, Gwangju 500-757, Republic of Korea. ; Department of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam Hospital, Seoul 151-742, Republic of Korea. ; Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea. ; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. ; Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, New York, 10065, USA. ; Duke-NUS Graduate Medical School, Singapore 169857, Singapore. ; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA. ; Fondazione IRCCS Istituto Nazionale dei Tumori, Milano 20133, Italy. ; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ; Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. ; Department of Etiology &Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. ; Department of Human Genetics, Genome Institute of Singapore 138672, Singapore. ; Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw 02-781, Poland. ; Yale School of Public Health, New Haven, Connecticut 06510, USA. ; H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA. ; Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain. ; Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan. ; Department of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, and Center for Community-Engaged Translational Research, Duncan Family Institute, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ; Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA. ; Lung Cancer Center, Kyungpook National University Medical Center, Daegu 101, Republic of Korea. ; Department of Pediatrics, University Clinic of Navarra, Universidad de Navarra, IdiSNA, Navarra Institute for Health Research, Pamplona 31080, Spain. ; Nofer Institute of Occupational Medicine, Lodz 91-348, Poland. ; University of Southern California, Los Angeles, California 90007, USA. ; Department of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing 100730, China. ; Division of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London SW7 2AZ, UK. ; Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona 08002, Spain. ; Karmanos Cancer Institute and Department of Family Medicine and Public Health Sciences, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. ; Saw Swee Hock School of Public Health, National University of Singapore, Singapore 119077, Singapore. ; Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Nanjing Medical University, Nanjing 210029, China. ; Department of Preventive Medicine, Chonnam National University Medical School, Gwanju 501-746, Republic of Korea. ; Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. ; Baylor College of Medicine, Houston, Texas 77030, USA. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21218, USA. ; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China. ; Information Management Services Inc., Calverton, Maryland, 20904, USA. ; University of California San Francisco, San Francisco, California 94143, USA. ; Department of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. ; Institute of Occupational Medicine and Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan 430400, China. ; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. ; Guangdong Lung Cancer Institute, Guangdong General Hospital &Guangdong Academy of Medical Sciences, Guangzhou 515200, China. ; Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA. ; New York University Cancer Institute, New York, New York 10016, USA. ; Department of Epidemiology, School of Public Health, China Medical University, Shenyang 110001, China. Y1 - 2016/06/13/ PY - 2016 DA - 2016 Jun 13 SP - 11843 VL - 7 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1796682733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+communications&rft.atitle=Female+chromosome+X+mosaicism+is+age-related+and+preferentially+affects+the+inactivated+X+chromosome.&rft.au=Machiela%2C+Mitchell+J%3BZhou%2C+Weiyin%3BKarlins%2C+Eric%3BSampson%2C+Joshua+N%3BFreedman%2C+Neal+D%3BYang%2C+Qi%3BHicks%2C+Belynda%3BDagnall%2C+Casey%3BHautman%2C+Christopher%3BJacobs%2C+Kevin+B%3BAbnet%2C+Christian+C%3BAldrich%2C+Melinda+C%3BAmos%2C+Christopher%3BAmundadottir%2C+Laufey+T%3BArslan%2C+Alan+A%3BBeane-Freeman%2C+Laura+E%3BBerndt%2C+Sonja+I%3BBlack%2C+Amanda%3BBlot%2C+William+J%3BBock%2C+Cathryn+H%3BBracci%2C+Paige+M%3BBrinton%2C+Louise+A%3BBueno-de-Mesquita%2C+H+Bas%3BBurdett%2C+Laurie%3BBuring%2C+Julie+E%3BButler%2C+Mary+A%3BCanzian%2C+Federico%3BCarre%C3%B3n%2C+Tania%3BChaffee%2C+Kari+G%3BChang%2C+I-Shou%3BChatterjee%2C+Nilanjan%3BChen%2C+Chu%3BChen%2C+Constance%3BChen%2C+Kexin%3BChung%2C+Charles+C%3BCook%2C+Linda+S%3BCrous+Bou%2C+Marta%3BCullen%2C+Michael%3BDavis%2C+Faith+G%3BDe+Vivo%2C+Immaculata%3BDing%2C+Ti%3BDoherty%2C+Jennifer%3BDuell%2C+Eric+J%3BEpstein%2C+Caroline+G%3BFan%2C+Jin-Hu%3BFigueroa%2C+Jonine+D%3BFraumeni%2C+Joseph+F%3BFriedenreich%2C+Christine+M%3BFuchs%2C+Charles+S%3BGallinger%2C+Steven%3BGao%2C+Yu-Tang%3BGapstur%2C+Susan+M%3BGarcia-Closas%2C+Montserrat%3BGaudet%2C+Mia+M%3BGaziano%2C+J+Michael%3BGiles%2C+Graham+G%3BGillanders%2C+Elizabeth+M%3BGiovannucci%2C+Edward+L%3BGoldin%2C+Lynn%3BGoldstein%2C+Alisa+M%3BHaiman%2C+Christopher+A%3BHallmans%2C+Goran%3BHankinson%2C+Susan+E%3BHarris%2C+Curtis+C%3BHenriksson%2C+Roger%3BHolly%2C+Elizabeth+A%3BHong%2C+Yun-Chul%3BHoover%2C+Robert+N%3BHsiung%2C+Chao+A%3BHu%2C+Nan%3BHu%2C+Wei%3BHunter%2C+David+J%3BHutchinson%2C+Amy%3BJenab%2C+Mazda%3BJohansen%2C+Christoffer%3BKhaw%2C+Kay-Tee%3BKim%2C+Hee+Nam%3BKim%2C+Yeul+Hong%3BKim%2C+Young+Tae%3BKlein%2C+Alison+P%3BKlein%2C+Robert%3BKoh%2C+Woon-Puay%3BKolonel%2C+Laurence+N%3BKooperberg%2C+Charles%3BKraft%2C+Peter%3BKrogh%2C+Vittorio%3BKurtz%2C+Robert+C%3BLaCroix%2C+Andrea%3BLan%2C+Qing%3BLandi%2C+Maria+Teresa%3BMarchand%2C+Loic+Le%3BLi%2C+Donghui%3BLiang%2C+Xiaolin%3BLiao%2C+Linda+M%3BLin%2C+Dongxin%3BLiu%2C+Jianjun%3BLissowska%2C+Jolanta%3BLu%2C+Lingeng%3BMagliocco%2C+Anthony+M%3BMalats%2C+Nuria%3BMatsuo%2C+Keitaro%3BMcNeill%2C+Lorna+H%3BMcWilliams%2C+Robert+R%3BMelin%2C+Beatrice+S%3BMirabello%2C+Lisa%3BMoore%2C+Lee%3BOlson%2C+Sara+H%3BOrlow%2C+Irene%3BPark%2C+Jae+Yong%3BPati%C3%B1o-Garcia%2C+Ana%3BPeplonska%2C+Beata%3BPeters%2C+Ulrike%3BPetersen%2C+Gloria+M%3BPooler%2C+Loreall%3BPrescott%2C+Jennifer%3BProkunina-Olsson%2C+Ludmila%3BPurdue%2C+Mark+P%3BQiao%2C+You-Lin%3BRajaraman%2C+Preetha%3BReal%2C+Francisco+X%3BRiboli%2C+Elio%3BRisch%2C+Harvey+A%3BRodriguez-Santiago%2C+Benjamin%3BRuder%2C+Avima+M%3BSavage%2C+Sharon+A%3BSchumacher%2C+Fredrick%3BSchwartz%2C+Ann+G%3BSchwartz%2C+Kendra+L%3BSeow%2C+Adeline%3BWendy+Setiawan%2C+Veronica%3BSeveri%2C+Gianluca%3BShen%2C+Hongbing%3BSheng%2C+Xin%3BShin%2C+Min-Ho%3BShu%2C+Xiao-Ou%3BSilverman%2C+Debra+T%3BSpitz%2C+Margaret+R%3BStevens%2C+Victoria+L%3BStolzenberg-Solomon%2C+Rachael%3BStram%2C+Daniel%3BTang%2C+Ze-Zhong%3BTaylor%2C+Philip+R%3BTeras%2C+Lauren+R%3BTobias%2C+Geoffrey+S%3BVan+Den+Berg%2C+David%3BVisvanathan%2C+Kala%3BWacholder%2C+Sholom%3BWang%2C+Jiu-Cun%3BWang%2C+Zhaoming%3BWentzensen%2C+Nicolas%3BWheeler%2C+William%3BWhite%2C+Emily%3BWiencke%2C+John+K%3BWolpin%2C+Brian+M%3BWong%2C+Maria+Pik%3BWu%2C+Chen%3BWu%2C+Tangchun%3BWu%2C+Xifeng%3BWu%2C+Yi-Long%3BWunder%2C+Jay+S%3BXia%2C+Lucy%3BYang%2C+Hannah+P%3BYang%2C+Pan-Chyr%3BYu%2C+Kai%3BZanetti%2C+Krista+A%3BZeleniuch-Jacquotte%2C+Anne%3BZheng%2C+Wei%3BZhou%2C+Baosen%3BZiegler%2C+Regina+G%3BPerez-Jurado%2C+Luis+A%3BCaporaso%2C+Neil+E%3BRothman%2C+Nathaniel%3BTucker%2C+Margaret%3BDean%2C+Michael+C%3BYeager%2C+Meredith%3BChanock%2C+Stephen+J&rft.aulast=Machiela&rft.aufirst=Mitchell&rft.date=2016-06-13&rft.volume=7&rft.issue=&rft.spage=11843&rft.isbn=&rft.btitle=&rft.title=Nature+communications&rft.issn=2041-1723&rft_id=info:doi/10.1038%2Fncomms11843 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/ncomms11843 ER - TY - JOUR T1 - Incorporation of Propionibacteria in Fermented Milks as a Probiotic AN - 1808610034; PQ0003264963 AB - Propionibacteria are mainly found in dairy products and fermented milks but are found in other foods as well. Dairy propionibacteria have recently shown to exert potential probiotic activities such as production of propionic acid, vitamins, bacteriocins, essential enzymes, and other vital metabolites. Furthermore, stimulating the immune system and lowering the blood cholesterol level are some of their favorable effects. They have a wide spectrum of antimicrobial activities, inhibiting the growth of gram-positive and some gram-negative bacteria, as well as some yeasts and molds. At industrial scale, they are used in cheese making, especially Swiss (hard) cheeses, as dominant starter cultures. There is a rising trend to use propionibacteria in fermented milks as probiotic. The current paper reviews the characteristics of propionibacteria related to their use in fermented milks either as starter culture or probiotic, methods for the enumeration of propionibacteria, and their functional (in vivo) efficiency. JF - Critical Reviews in Food Science and Nutrition AU - Moslemi, M AU - Mazaheri Nezhad Fard, R AU - Hosseini, S M AU - Homayouni-Rad, A AU - Mortazavian, Amir M AD - Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran Y1 - 2016/06/10/ PY - 2016 DA - 2016 Jun 10 SP - 1290 EP - 1312 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 56 IS - 8 SN - 1040-8398, 1040-8398 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Starter cultures KW - Bacteriocins KW - Antimicrobial activity KW - Milk KW - Immune system KW - Food KW - Dairy products KW - Propionic acid KW - probiotics KW - Enzymes KW - Molds KW - Metabolites KW - Cholesterol KW - Cheese KW - Blood KW - Gram-negative bacteria KW - Vitamins KW - A 01330:Food Microbiology KW - J 02350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808610034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Food+Science+and+Nutrition&rft.atitle=Incorporation+of+Propionibacteria+in+Fermented+Milks+as+a+Probiotic&rft.au=Moslemi%2C+M%3BMazaheri+Nezhad+Fard%2C+R%3BHosseini%2C+S+M%3BHomayouni-Rad%2C+A%3BMortazavian%2C+Amir+M&rft.aulast=Moslemi&rft.aufirst=M&rft.date=2016-06-10&rft.volume=56&rft.issue=8&rft.spage=1290&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Food+Science+and+Nutrition&rft.issn=10408398&rft_id=info:doi/10.1080%2F10408398.2013.766584 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Bacteriocins; Starter cultures; Antimicrobial activity; Milk; Food; Immune system; probiotics; Propionic acid; Dairy products; Molds; Enzymes; Metabolites; Cholesterol; Cheese; Blood; Vitamins; Gram-negative bacteria DO - http://dx.doi.org/10.1080/10408398.2013.766584 ER - TY - JOUR T1 - Prediction of non-muscle invasive bladder cancer outcomes assessed by innovative multimarker prognostic models. AN - 1794472732; 27259534 AB - We adapted Bayesian statistical learning strategies to the prognosis field to investigate if genome-wide common SNP improve the prediction ability of clinico-pathological prognosticators and applied it to non-muscle invasive bladder cancer (NMIBC) patients. Adapted Bayesian sequential threshold models in combination with LASSO were applied to consider the time-to-event and the censoring nature of data. We studied 822 NMIBC patients followed-up >10 years. The study outcomes were time-to-first-recurrence and time-to-progression. The predictive ability of the models including up to 171,304 SNP and/or 6 clinico-pathological prognosticators was evaluated using AUC-ROC and determination coefficient. Clinico-pathological prognosticators explained a larger proportion of the time-to-first-recurrence (3.1 %) and time-to-progression (5.4 %) phenotypic variances than SNPs (1 and 0.01 %, respectively). Adding SNPs to the clinico-pathological-parameters model slightly improved the prediction of time-to-first-recurrence (up to 4 %). The prediction of time-to-progression using both clinico-pathological prognosticators and SNP did not improve. Heritability (ĥ (2)) of both outcomes was <1 % in NMIBC. We adapted a Bayesian statistical learning method to deal with a large number of parameters in prognostic studies. Common SNPs showed a limited role in predicting NMIBC outcomes yielding a very low heritability for both outcomes. We report for the first time a heritability estimate for a disease outcome. Our method can be extended to other disease models. JF - BMC cancer AU - López de Maturana, E AU - Picornell, A AU - Masson-Lecomte, A AU - Kogevinas, M AU - Márquez, M AU - Carrato, A AU - Tardón, A AU - Lloreta, J AU - García-Closas, M AU - Silverman, D AU - Rothman, N AU - Chanock, S AU - Real, F X AU - Goddard, M E AU - Malats, N AU - SBC/EPICURO Study Investigators AD - Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández, Almagro, 3, 28029, Madrid, Spain. ; Centre for Research in Environmental Epidemiology (CREAL), Parc de Salut Mar, Barcelona, Spain. ; Servicio de Oncología, Hospital Universitario Ramon y Cajal, Madrid, and Servicio de Oncología, Hospital Universitario de Elche, Elche, Spain. ; Department of Preventive Medicine Universidad de Oviedo, Oviedo, Spain. ; Parc de Salut Mar and Departament of Pathology, Hospital del Mar - IMAS, Barcelona, Spain. ; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland, USA. ; Epithelial Carcinogenesis Group, Spanish National Cancer Research Centre (CNIO), Madrid, and Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain. ; Biosciences Research Division, Department of Environment and Primary Industries, Agribio, and Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Australia. ; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández, Almagro, 3, 28029, Madrid, Spain. nmalats@cnio.es. ; SBC/EPICURO Study Investigators Y1 - 2016/06/03/ PY - 2016 DA - 2016 Jun 03 SP - 351 VL - 16 KW - Index Medicus KW - Illumina Infinium HumanHap 1 M array KW - Prognosis KW - AUC-ROC KW - Bayesian regression KW - Recurrence KW - Progression KW - Determination coefficient KW - Bladder cancer outcome KW - Genome-wide common SNP KW - Predictive ability KW - Bayesian LASSO KW - heritability KW - Multimarker models KW - Bayesian statistical learning method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1794472732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Prediction+of+non-muscle+invasive+bladder+cancer+outcomes+assessed+by+innovative+multimarker+prognostic+models.&rft.au=L%C3%B3pez+de+Maturana%2C+E%3BPicornell%2C+A%3BMasson-Lecomte%2C+A%3BKogevinas%2C+M%3BM%C3%A1rquez%2C+M%3BCarrato%2C+A%3BTard%C3%B3n%2C+A%3BLloreta%2C+J%3BGarc%C3%ADa-Closas%2C+M%3BSilverman%2C+D%3BRothman%2C+N%3BChanock%2C+S%3BReal%2C+F+X%3BGoddard%2C+M+E%3BMalats%2C+N%3BSBC%2FEPICURO+Study+Investigators&rft.aulast=L%C3%B3pez+de+Maturana&rft.aufirst=E&rft.date=2016-06-03&rft.volume=16&rft.issue=&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/10.1186%2Fs12885-016-2361-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12885-016-2361-7 ER - TY - GEN T1 - Policy Statement on Supporting the Development of Children Who Are Dual Language Learners in Early Childhood Programs AN - 1826530175; ED566723 AB - The purpose of this policy statement is to support early childhood programs and States by providing recommendations that promote the development and learning of young children, birth to age five, who are dual language learners (DLLs). The statement also provides support to tribal communities in their language revitalization efforts within tribal early childhood programs. National estimates indicate that there is a large and growing population of children who are DLLs--children who have a home language other than English and are learning two or more languages at the same time, or learning a second language while continuing to develop their first language. Early childhood programs should be prepared to optimize the early experiences of these young children by holding high expectations, capitalizing on their strengths- including cultural and linguistic strengths--and providing them with the individualized developmental and learning supports necessary to succeed in school. Y1 - 2016/06/02/ PY - 2016 DA - 2016 Jun 02 SP - 32 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - Child Care and Development Block Grants KW - Individuals with Disabilities Education Act Part C KW - Civil Rights Act 1964 Title VI KW - Equal Educational Opportunities Act 1974 KW - Elementary Secondary Education Act Title III KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Elementary Secondary Education KW - Language Acquisition KW - Federal Aid KW - Access to Education KW - Child Care KW - Legal Responsibility KW - Disabilities KW - Achievement Gap KW - Child Development KW - Multilingualism KW - State Policy KW - Educational Legislation KW - Young Children KW - Grants KW - Second Language Learning KW - Equal Education KW - Civil Rights Legislation KW - Block Grants KW - Bilingual Students KW - Neuropsychology KW - Federal Legislation KW - Educational Practices KW - Educational Policy KW - Change Strategies KW - Early Experience KW - Native Speakers KW - Related Services (Special Education) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826530175?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Characterising variances of milk powder and instrumentation for the development of a non-targeted, Raman spectroscopy and chemometrics detection method for the evaluation of authenticity AN - 1808656896; PQ0003401873 AB - There is a need to develop rapid tools to screen milk products for economically motivated adulteration. An understanding of the physiochemical variability within skim milk powder (SMP) and non-fat dry milk (NFDM) is the key to establishing the natural differences of these commodities prior to the development of non-targeted detection methods. This study explored the sources of variance in 71 commercial SMP and NFDM samples using Raman spectroscopy and principal component analysis (PCA) and characterised the largest number of commercial milk powders acquired from a broad number of international manufacturers. Spectral pre-processing using a gap-segment derivative transformation (gap size = 5, segment width = 9, fourth derivative) in combination with sample normalisation was necessary to reduce the fluorescence background of the milk powder samples. PC scores plots revealed no clear trends for various parameters, including day of analysis, powder type, supplier and processing temperatures, while the largest variance was due to irreproducibility in sample positioning. Significant chemical sources of variances were explained by using the spectral features in the PC loadings plots where four samples from the same manufacturer were determined to likely contain an additional component or lactose anomers, and one additional sample was identified as an outlier and likely containing an adulterant or differing quality components. The variance study discussed herein with this large, diverse set of milk powders holds promise for future use as a non-targeted screening method that could be applied to commercial milk powders. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Karunathilaka, Sanjeewa R AU - Farris, Samantha AU - Mossoba, Magdi M AU - Moore, Jeffrey C AU - Yakes, Betsy Jean AD - US Food and Drug Administration (USFDA), Center for Food Safety and Applied Nutrition, Office of Regulatory Science, College Park, MD, USA Y1 - 2016/06/02/ PY - 2016 DA - 2016 Jun 02 SP - 921 EP - 932 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 6 SN - 1944-0049, 1944-0049 KW - Toxicology Abstracts; Environment Abstracts KW - Temperature effects KW - Risk assessment KW - Transformation KW - Powder KW - Lactose KW - Milk KW - Fluorescence KW - Temperature KW - Skim milk KW - Spectroscopy KW - Food contamination KW - Raman spectroscopy KW - Food additives KW - Milk products KW - Derivatives KW - Principal components analysis KW - Authenticity KW - X 24320:Food Additives & Contaminants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808656896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Characterising+variances+of+milk+powder+and+instrumentation+for+the+development+of+a+non-targeted%2C+Raman+spectroscopy+and+chemometrics+detection+method+for+the+evaluation+of+authenticity&rft.au=Karunathilaka%2C+Sanjeewa+R%3BFarris%2C+Samantha%3BMossoba%2C+Magdi+M%3BMoore%2C+Jeffrey+C%3BYakes%2C+Betsy+Jean&rft.aulast=Karunathilaka&rft.aufirst=Sanjeewa&rft.date=2016-06-02&rft.volume=33&rft.issue=6&rft.spage=921&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1188437 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Transformation; Risk assessment; Temperature effects; Raman spectroscopy; Powder; Lactose; Milk products; Food additives; Fluorescence; Principal components analysis; Skim milk; Food contamination; Derivatives; Milk; Temperature; Spectroscopy; Authenticity DO - http://dx.doi.org/10.1080/19440049.2016.1188437 ER - TY - JOUR T1 - Identification of a new tadalafil analogue, dipropylaminopretadalafil, in a dietary supplement AN - 1808632389; PQ0003401876 AB - A novel tadalafil analogue in a dietary supplement was found by drug-adulteration screening and isolated by column chromatography and HPLC. Based on extensive 1D- and 2D-NMR and mass spectral analyses, the structure of this new compound was determined as 2-(N,N-dipropyl acetyl) 3-methyl 1-(benzo[d][1,3]dioxol-5-yl)-3,4-dihydro-1H-pyrido[3,4-b]indole-3- c arboxylate - its common name is dipropylaminopretadalafil. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Huang, Yen-Chun AU - Lee, Hui-Chun AU - Lin, Yun-Lian AU - Tsai, Chia-Fen AU - Cheng, Hwei-Fang AD - Division of Research and Analysis, Taiwan Food and Drug Administration, Taipei, Taiwan (R.O.C) Y1 - 2016/06/02/ PY - 2016 DA - 2016 Jun 02 SP - 953 EP - 958 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 6 SN - 1944-0049, 1944-0049 KW - Toxicology Abstracts; Environment Abstracts KW - Risk assessment KW - High-performance liquid chromatography KW - Food additives KW - Chromatography KW - Dietary supplements KW - Column chromatography KW - Food contamination KW - X 24320:Food Additives & Contaminants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808632389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Identification+of+a+new+tadalafil+analogue%2C+dipropylaminopretadalafil%2C+in+a+dietary+supplement&rft.au=Huang%2C+Yen-Chun%3BLee%2C+Hui-Chun%3BLin%2C+Yun-Lian%3BTsai%2C+Chia-Fen%3BCheng%2C+Hwei-Fang&rft.aulast=Huang&rft.aufirst=Yen-Chun&rft.date=2016-06-02&rft.volume=33&rft.issue=6&rft.spage=953&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1184530 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Risk assessment; Food additives; Dietary supplements; Column chromatography; Food contamination; Chromatography DO - http://dx.doi.org/10.1080/19440049.2016.1184530 ER - TY - JOUR T1 - A Qualitative Comparison of Susceptibility and Behavior in Recreational and Occupational Risk Environments: Implications for Promoting Health and Safety AN - 1808621520; PQ0003267531 AB - Although internal factors that influence risk are frequently studied to understand human behavior, external factors, including social, cultural, and institutional factors, should be better utilized to inform ways to efficiently target, tailor, and promote safety messaging to at-risk populations. Semi-structured interviews obtained data from 37 motorcyclists and 18 mineworkers about their risk perceptions and behaviors within their respective dynamic environments. A comparative thematic analysis revealed information about external factors that influence risk perceptions and behaviors. Results support the importance of qualitative approaches for assessing and targeting individuals' risk perceptions and behaviors. In addition, segmenting at-risk subgroups within target populations and tailoring messages for these at-risk groups is critical for safety behavior modification. Practitioners should utilize strategic, culture-centric risk communication that takes into account external factors when determining when, who, and what to communicate via health promotion activities to more accurately disseminate valid, empathetic, and engaging communication with a higher level of fidelity. JF - Journal of Health Communication AU - Haas, Emily Joy AU - Mattson, Marifran AD - Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania, USA Y1 - 2016/06/02/ PY - 2016 DA - 2016 Jun 02 SP - 705 EP - 713 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 21 IS - 6 SN - 1081-0730, 1081-0730 KW - Health & Safety Science Abstracts KW - Risk assessment KW - Culture KW - Safety KW - Risk taking KW - Human behavior KW - Communications KW - Perception KW - Recreation areas KW - Risk factors KW - Social behavior KW - Motorcycles KW - Health promotion KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808621520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Communication&rft.atitle=A+Qualitative+Comparison+of+Susceptibility+and+Behavior+in+Recreational+and+Occupational+Risk+Environments%3A+Implications+for+Promoting+Health+and+Safety&rft.au=Haas%2C+Emily+Joy%3BMattson%2C+Marifran&rft.aulast=Haas&rft.aufirst=Emily&rft.date=2016-06-02&rft.volume=21&rft.issue=6&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2016.1153765 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Risk assessment; Human behavior; Culture; Communications; Recreation areas; Perception; Risk factors; Safety; Social behavior; Risk taking; Motorcycles; Health promotion DO - http://dx.doi.org/10.1080/10810730.2016.1153765 ER - TY - JOUR T1 - Novel Time-Resolved Fluorescence Europium Nanoparticle Immunoassay for Detection of Human Immunodeficiency Virus-1 Group O Viruses Using Microplate and Microchip Platforms AN - 1859483829; PQ0003988348 AB - Accurate detection and quantification of HIV-1 group O viruses have been challenging for currently available HIV assays. We have developed a novel time-resolved fluorescence (TRF) europium nanoparticle immunoassay for HIV-1 group O detection using a conventional microplate enzyme-linked immunosorbent assay (ELISA) and a microchip platform. We screened several antibodies for optimal reactivity with several HIV-1 group O strains and identified antibodies that can detect all the strains of HIV-1 group O that were available for testing. The antibodies were used to develop a conventional ELISA format assay and an in-house developed europium nanoparticle-based assay for sensitivity. The method was evaluated on both microwell plate and microchip platforms. We identified two specific and sensitive antibodies among the six we screened. The antibodies, C65691 and ANT-152, were able to quantify 15 and detect all 17 group O viruses, respectively, as they were broadly cross-reactive with all HIV-1 group O strains and yielded better signals compared with other antibodies. We have developed a sensitive assay that reflects the actual viral load in group O samples by using an appropriate combination of p24 antibodies that enhance group O detection and a highly sensitive TRF-based europium nanoparticle for detection. The combination of ANT-152 and C65690M in the ratio 3:1 was able to give significantly higher signals in our europium-based assay compared with using any single antibody. JF - AIDS Research and Human Retroviruses AU - Haleyur Giri Setty, Mohan Kumar AU - Liu, Jikun AU - Mahtani, Prerna AU - Zhang, Panhe AU - Du, Bingchen AU - Ragupathy, Viswanath AU - Devadas, Krishnakumar AU - Hewlett, Indira K AD - Laboratory of Molecular Virology, CBER, FDA, Silver Spring, Maryland. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 612 EP - 619 PB - Mary Ann Liebert, Inc., 140 Huguenot Street New Rochelle NY 10801 United States VL - 32 IS - 6 SN - 0889-2229, 0889-2229 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Sensitivity KW - Acquired immune deficiency syndrome KW - Enzyme-linked immunosorbent assay KW - Fluorescence KW - Retroviridae KW - Europium KW - Viruses KW - Immunodeficiency KW - Antibodies KW - Lentivirus KW - microchips KW - Immunoassays KW - nanoparticles KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859483829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Research+and+Human+Retroviruses&rft.atitle=Novel+Time-Resolved+Fluorescence+Europium+Nanoparticle+Immunoassay+for+Detection+of+Human+Immunodeficiency+Virus-1+Group+O+Viruses+Using+Microplate+and+Microchip+Platforms&rft.au=Haleyur+Giri+Setty%2C+Mohan+Kumar%3BLiu%2C+Jikun%3BMahtani%2C+Prerna%3BZhang%2C+Panhe%3BDu%2C+Bingchen%3BRagupathy%2C+Viswanath%3BDevadas%2C+Krishnakumar%3BHewlett%2C+Indira+K&rft.aulast=Haleyur+Giri+Setty&rft.aufirst=Mohan&rft.date=2016-06-01&rft.volume=32&rft.issue=6&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=AIDS+Research+and+Human+Retroviruses&rft.issn=08892229&rft_id=info:doi/10.1089%2Faid.2014.0351 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 42 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Antibodies; Fluorescence; microchips; Immunodeficiency; nanoparticles; Sensitivity; Acquired immune deficiency syndrome; Viruses; Europium; Immunoassays; Lentivirus; Retroviridae DO - http://dx.doi.org/10.1089/aid.2014.0351 ER - TY - JOUR T1 - Informed Consent Should Be a Required Element for Newborn Screening, Even for Disorders with High Benefit-Risk Ratios AN - 1839207575 AB - Over-enthusiastic newborn screening has often caused substantial harm and has been imposed on the public without adequate information on benefits and risks and without parental consent. This problem will become worse when genomic screening is implemented. For the past 40 years, there has been broad agreement about the criteria for ethically responsible screening, but the criteria have been systematically ignored by policy makers and practitioners. Claims of high benefit and low risk are common, but they require precise definition and documentation, which has often not occurred, undermining claims that involuntary testing is justified. Even when the benefits and risks are well established, it does not automatically follow that involuntary testing is justified, a position supported by the widespread tolerance for parental refusal of immunizations and newborn screening. JF - The Journal of Law, Medicine & Ethics AU - Fost, Norman AD - Norman Fost, M.D., M.P.H., Professor Emeritus of Pediatrics at the University of Wisconsin, founded the Bioethics Program and the Child Protection Team at UW in 1973. He was been Chair of the Hospital Ethics Committee since 1984, and, for 31 years, chaired the Health Sciences Institutional Review Board. Dr. Fost has received lifetime achievement awards from the American Academy of Pediatrics and the Office of Human Subjects Protection, and was the first recipient of the Patricia Price Browne Prize in Bioethics. He has served on the FDA Pediatric Advisory Committee and is a member of the NIH Recombinant DNA Advisory Committee. ; Norman Fost, M.D., M.P.H., Professor Emeritus of Pediatrics at the University of Wisconsin, founded the Bioethics Program and the Child Protection Team at UW in 1973. He was been Chair of the Hospital Ethics Committee since 1984, and, for 31 years, chaired the Health Sciences Institutional Review Board. Dr. Fost has received lifetime achievement awards from the American Academy of Pediatrics and the Office of Human Subjects Protection, and was the first recipient of the Patricia Price Browne Prize in Bioethics. He has served on the FDA Pediatric Advisory Committee and is a member of the NIH Recombinant DNA Advisory Committee. Y1 - 2016/06// PY - 2016 DA - Jun 2016 SP - 241 EP - 255 CY - Boston PB - SAGE PUBLICATIONS, INC. VL - 44 IS - 2 SN - 1073-1105 KW - Medical Sciences KW - Ethics KW - Informed Consent KW - Disorders KW - Documentation KW - Tolerance KW - Risk KW - Criteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1839207575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=Informed+Consent+Should+Be+a+Required+Element+for+Newborn+Screening%2C+Even+for+Disorders+with+High+Benefit-Risk+Ratios&rft.au=Fost%2C+Norman&rft.aulast=Fost&rft.aufirst=Norman&rft.date=2016-06-01&rft.volume=44&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1177%2F1073110516654118 LA - English DB - PAIS Index N1 - Copyright - © 2016 American Society of Law, Medicine & Ethics N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1177/1073110516654118 ER - TY - GEN T1 - Corrigendum to "Combination therapy with lenalidomide and nanoceria ameliorates CNS autoimmunity", [Exp. Neurol. 273 (2015), 151-160]. AN - 1826678790; 27149927 JF - Experimental neurology AU - Eitan, Erez AU - Hutchison, Emmette R AU - Greig, Nigel H AU - Tweedie, David AU - Celik, Hasan AU - Ghosh, Soumita AU - Fishbein, Kenneth W AU - Spencer, Richard G AU - Sasaki, Carl Y AU - Ghosh, Paritosh AU - Das, Soumen AU - Chigurapati, Susheela AU - Raymick, James AU - Sarkar, Sumit AU - Chigurupati, Srinivasulu AU - Seal, Sudipta AU - Mattson, Mark P Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 121 VL - 280 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826678790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Experimental+neurology&rft.atitle=Corrigendum+to+%22Combination+therapy+with+lenalidomide+and+nanoceria+ameliorates+CNS+autoimmunity%22%2C+%5BExp.+Neurol.+273+%282015%29%2C+151-160%5D.&rft.au=Eitan%2C+Erez%3BHutchison%2C+Emmette+R%3BGreig%2C+Nigel+H%3BTweedie%2C+David%3BCelik%2C+Hasan%3BGhosh%2C+Soumita%3BFishbein%2C+Kenneth+W%3BSpencer%2C+Richard+G%3BSasaki%2C+Carl+Y%3BGhosh%2C+Paritosh%3BDas%2C+Soumen%3BChigurapati%2C+Susheela%3BRaymick%2C+James%3BSarkar%2C+Sumit%3BChigurupati%2C+Srinivasulu%3BSeal%2C+Sudipta%3BMattson%2C+Mark+P&rft.aulast=Eitan&rft.aufirst=Erez&rft.date=2016-06-01&rft.volume=280&rft.issue=&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=1090-2430&rft_id=info:doi/10.1016%2Fj.expneurol.2016.02.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-06 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.expneurol.2016.02.015 ER - TY - JOUR T1 - Environmental release of core-shell semiconductor nanocrystals from free-standing polymer nanocomposite films AN - 1808729213; PQ0003317607 AB - Concomitant with the development of polymer nanocomposite (PNC) technologies across numerous industries is an expanding awareness of the uncertainty with which engineered nanoparticles embedded within these materials may be released into the external environment, particularly liquid media. Recently there has been an interest in evaluating potential exposure to nanoscale fillers from PNCs, but existing studies often rely upon uncharacterized, poor quality, or proprietary materials, creating a barrier to making general mechanistic conclusions about release phenomena. In this study we employed semiconductor nanoparticles (quantum dots, QDs) as model nanofillers to quantify potential release into liquid media under specific environmental conditions. QDs of two sizes were incorporated into low-density polyethylene by melt compounding and the mixtures were extruded as free-standing fluorescent films. These films were subjected to tests under conditions intended to accelerate potential release of embedded particles or dissolved residuals into liquid environments. Using inductively-coupled plasma mass spectrometry and laser scanning confocal microscopy, it was found that the acidity of the external medium, exposure time, and small differences in particle size (on the order of a few nm) all play pivotal roles in release kinetics. Particle dissolution was found to play a major if not dominant role in the release process. This paper also presents the first evidence that internally embedded nanoparticles contribute to the mass transfer, an observation made possible viathe use of a model system that was deliberately designed to probe the complex relationships between nanoparticle-enabled plastics and the environment. JF - Environmental Science: Nano AU - V Pillai, Karthik AU - Gray, Patrick J AU - Tien, Chun-Chieh AU - Bleher, Reiner AU - Sung, Li-Piin AU - V Duncan, Timothy AD - Center for Food Safety and Applied Nutrition; US Food and Drug Administration; 6502 South Archer Road; Bedford Park; IL; 60501; USA Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 657 EP - 669 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 3 IS - 3 SN - 2051-8153, 2051-8153 KW - Environment Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts; Water Resources Abstracts KW - Environmental release KW - Mass Spectrometry KW - Barriers KW - Particle Size KW - Mass spectrometry KW - Particulates KW - Environmental factors KW - Exposure KW - Acidity KW - Modelling KW - Particle size KW - Mass Transfer KW - Kinetics KW - Microscopy KW - Lasers KW - Mass transfer KW - Environmental conditions KW - Polymers KW - Technology KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - Q5 08502:Methods and instruments KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808729213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Science%3A+Nano&rft.atitle=Environmental+release+of+core-shell+semiconductor+nanocrystals+from+free-standing+polymer+nanocomposite+films&rft.au=V+Pillai%2C+Karthik%3BGray%2C+Patrick+J%3BTien%2C+Chun-Chieh%3BBleher%2C+Reiner%3BSung%2C+Li-Piin%3BV+Duncan%2C+Timothy&rft.aulast=V+Pillai&rft.aufirst=Karthik&rft.date=2016-06-01&rft.volume=3&rft.issue=3&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Environmental+Science%3A+Nano&rft.issn=20518153&rft_id=info:doi/10.1039%2Fc6en00064a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 47 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Particle size; Barriers; Mass transfer; Polymers; Acidity; Environmental conditions; Environmental factors; Modelling; Environmental release; Kinetics; Microscopy; Mass spectrometry; Particulates; Technology; Mass Spectrometry; Particle Size; Exposure; Mass Transfer; Lasers DO - http://dx.doi.org/10.1039/c6en00064a ER - TY - JOUR T1 - A Nonautochthonous U.S. Strain of Vibrio parahaemolyticus Isolated from Chesapeake Bay Oysters Caused the Outbreak in Maryland in 2010 AN - 1808723541; PQ0003229816 AB - In the summer of 2010, Vibrio parahaemolyticus caused an outbreak in Maryland linked to the consumption of oysters. Strains isolated from both stool and oyster samples were indistinguishable by pulsed-field gel electrophoresis (PFGE). However, the oysters contained other potentially pathogenic V. parahaemolyticus strains exhibiting different PFGE patterns. In order to assess the identity, genetic makeup, relatedness, and potential pathogenicity of the V. parahaemolyticus strains, we sequenced 11 such strains (2 clinical strains and 9 oyster strains). We analyzed these genomes by in silico multilocus sequence typing (MLST) and determined their phylogeny using a whole-genome MLST (wgMLST) analysis. Our in silico MLST analysis identified six different sequence types (STs) (ST8, ST676, ST810, ST811, ST34, and ST768), with both of the clinical and four of the oyster strains being identified as belonging to ST8. Using wgMLST, we showed that the ST8 strains from clinical and oyster samples were nearly indistinguishable and belonged to the same outbreak, confirming that local oysters were the source of the infections. The remaining oyster strains were genetically diverse, differing in >3,000 loci from the Maryland ST8 strains. eBURST analysis comparing these strains with strains of other STs available at the V. parahaemolyticus MLST website showed that the Maryland ST8 strains belonged to a clonal complex endemic to Asia. This indicates that the ST8 isolates from clinical and oyster sources were likely not endemic to Maryland. Finally, this study demonstrates the utility of whole-genome sequencing (WGS) and associated analyses for source-tracking investigations. IMPORTANCE Vibrio parahaemolyticus is an important foodborne pathogen and the leading cause of bacterial infections in the United States associated with the consumption of seafood. In the summer of 2010, Vibrio parahaemolyticus caused an outbreak in Maryland linked to oyster consumption. Strains isolated from stool and oyster samples were indistinguishable by pulsed-field gel electrophoresis (PFGE). The oysters also contained other potentially pathogenic V. parahaemolyticus strains with different PFGE patterns. Since their identity, genetic makeup, relatedness, and potential pathogenicity were unknown, their genomes were determined by using next-generation sequencing. Whole-genome sequencing (WGS) analysis by whole-genome multilocus sequence typing (wgMLST) allowed (i) identification of clinical and oyster strains with matching PFGE profiles as belonging to ST8, (ii) determination of oyster strain diversity, and (iii) identification of the clinical strains as belonging to a clonal complex (CC) described only in Asia. Finally, WGS and associated analyses demonstrated their utility for trace-back investigations. JF - Antimicrobial Agents & Chemotherapy AU - Haendiges, Julie AU - Jones, Jessica AU - Myers, Robert A AU - Mitchell, Clifford S AU - Butler, Erin AU - Toro, Magaly AU - Gonzalez-Escalona, Narjol AD - << + $0, narjol.gonzalez-escalona@fda.hhs.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 3208 EP - 3216 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 11 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Phylogeny KW - Pathogenicity KW - Vibrio parahaemolyticus KW - Food KW - Pulsed-field gel electrophoresis KW - Seafood KW - Pathogens KW - Infection KW - Feces KW - multilocus sequence typing KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808723541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=A+Nonautochthonous+U.S.+Strain+of+Vibrio+parahaemolyticus+Isolated+from+Chesapeake+Bay+Oysters+Caused+the+Outbreak+in+Maryland+in+2010&rft.au=Haendiges%2C+Julie%3BJones%2C+Jessica%3BMyers%2C+Robert+A%3BMitchell%2C+Clifford+S%3BButler%2C+Erin%3BToro%2C+Magaly%3BGonzalez-Escalona%2C+Narjol&rft.aulast=Haendiges&rft.aufirst=Julie&rft.date=2016-06-01&rft.volume=82&rft.issue=11&rft.spage=3208&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00096-16 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 36 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Genomes; Pathogenicity; Food; Pulsed-field gel electrophoresis; Pathogens; Seafood; Feces; Infection; multilocus sequence typing; Vibrio parahaemolyticus DO - http://dx.doi.org/10.1128/AEM.00096-16 ER - TY - JOUR T1 - FDA Escherichia coli Identification (FDA-ECID) Microarray: a Pangenome Molecular Toolbox for Serotyping, Virulence Profiling, Molecular Epidemiology, and Phylogeny AN - 1808721758; PQ0003229839 AB - Most Escherichia coli strains are nonpathogenic. However, for clinical diagnosis and food safety analysis, current identification methods for pathogenic E. coli either are time-consuming and/or provide limited information. Here, we utilized a custom DNA microarray with informative genetic features extracted from 368 sequence sets for rapid and high-throughput pathogen identification. The FDA Escherichia coli Identification (FDA-ECID) platform contains three sets of molecularly informative features that together stratify strain identification and relatedness. First, 53 known flagellin alleles, 103 alleles of wzx and wzy, and 5 alleles of wzm provide molecular serotyping utility. Second, 41,932 probe sets representing the pan-genome of E. coli provide strain-level gene content information. Third, approximately 125,000 single nucleotide polymorphisms (SNPs) of available whole-genome sequences (WGS) were distilled to 9,984 SNPs capable of recapitulating the E. coli phylogeny. We analyzed 103 diverse E. coli strains with available WGS data, including those associated with past foodborne illnesses, to determine robustness and accuracy. The array was able to accurately identify the molecular O and H serotypes, potentially correcting serological failures and providing better resolution for H-nontypeable/nonmotile phenotypes. In addition, molecular risk assessment was possible with key virulence marker identifications. Epidemiologically, each strain had a unique comparative genomic fingerprint that was extended to an additional 507 food and clinical isolates. Finally, a 99.7% phylogenetic concordance was established between microarray analysis and WGS using SNP-level data for advanced genome typing. Our study demonstrates FDA-ECID as a powerful tool for epidemiology and molecular risk assessment with the capacity to profile the global landscape and diversity of E. coli. IMPORTANCE This study describes a robust, state-of-the-art platform developed from available whole-genome sequences of E. coli and Shigella spp. by distilling useful signatures for epidemiology and molecular risk assessment into one assay. The FDA-ECID microarray contains features that enable comprehensive molecular serotyping and virulence profiling along with genome-scale genotyping and SNP analysis. Hence, it is a molecular toolbox that stratifies strain identification and pathogenic potential in the contexts of epidemiology and phylogeny. We applied this tool to strains from food, environmental, and clinical sources, resulting in significantly greater phylogenetic and strain-specific resolution than previously reported for available typing methods. JF - Antimicrobial Agents & Chemotherapy AU - Patel, Isha R AU - Gangiredla, Jayanthi AU - Lacher, David W AU - Mammel, Mark K AU - Jackson, Scott A AU - Lampel, Keith A AU - Elkins, Christopher A Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 3384 EP - 3394 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 11 SN - 0099-2240, 0099-2240 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - Genomes KW - Risk assessment KW - Phylogeny KW - Serotypes KW - Data processing KW - Food KW - Genotyping KW - DNA probes KW - Landscape KW - Serotyping KW - Shigella KW - Pathogens KW - DNA microarrays KW - Virulence KW - Epidemiology KW - Single-nucleotide polymorphism KW - Escherichia coli KW - genomics KW - Flagellin KW - J 02320:Cell Biology KW - A 01330:Food Microbiology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808721758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=FDA+Escherichia+coli+Identification+%28FDA-ECID%29+Microarray%3A+a+Pangenome+Molecular+Toolbox+for+Serotyping%2C+Virulence+Profiling%2C+Molecular+Epidemiology%2C+and+Phylogeny&rft.au=Patel%2C+Isha+R%3BGangiredla%2C+Jayanthi%3BLacher%2C+David+W%3BMammel%2C+Mark+K%3BJackson%2C+Scott+A%3BLampel%2C+Keith+A%3BElkins%2C+Christopher+A&rft.aulast=Patel&rft.aufirst=Isha&rft.date=2016-06-01&rft.volume=82&rft.issue=11&rft.spage=3384&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.04077-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 48 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Risk assessment; Genomes; Clinical isolates; Data processing; Serotypes; DNA probes; Genotyping; Food; Landscape; Serotyping; Pathogens; DNA microarrays; Virulence; Epidemiology; Single-nucleotide polymorphism; genomics; Flagellin; Escherichia coli; Shigella DO - http://dx.doi.org/10.1128/AEM.04077-15 ER - TY - JOUR T1 - Dose Finding of Small-Molecule Oncology Drugs: Optimization throughout the Development Life Cycle AN - 1808703153; PQ0003461300 AB - In the current era of rapid marketing approval for promising new products in oncology, dose finding and optimization for small-molecule oncology drugs occurs throughout the development cycle and into the postmarketing setting. Many trials that support a regulatory application have high rates of dose reductions and discontinuations, which may result in postmarketing requirements (PMR) to study alternate doses or dosing schedules. Kinase inhibitors particularly have been susceptible to this problem, and among the 31 approved drugs of this class, the approvals of eight have included such PMRs and/or commitments. Thus, the current paradigm for dose finding and optimization could be improved. Newer strategies for dose finding rather than traditional 3 + 3 designs should be considered where feasible, and dose optimization should be continued after phase I and throughout development. Such strategies will increase the likelihood of a right dose for the right drug at the time of regulatory approval. Clin Cancer Res; 22(11); 2613-7. copyright 2016 AACR.See all articles in this CCR Focus section, "New Approaches for Optimizing Dosing of Anticancer Agents." JF - Clinical Cancer Research AU - Janne, Pasi A AU - Kim, Geoffrey AU - Shaw, Alice T AU - Sridhara, Rajeshwari AU - Pazdur, Richard AU - McKee, Amy E AD - Dana-Farber Cancer Institute, Boston, Massachusetts, amy.mckee@fda.hhs.gov Y1 - 2016/06/01/ PY - 2016 DA - 2016 Jun 01 SP - 2613 EP - 2617 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 22 IS - 11 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Life cycle KW - Oncology KW - Drug development KW - Antitumor agents KW - Clinical trials KW - Drugs KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808703153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Dose+Finding+of+Small-Molecule+Oncology+Drugs%3A+Optimization+throughout+the+Development+Life+Cycle&rft.au=Janne%2C+Pasi+A%3BKim%2C+Geoffrey%3BShaw%2C+Alice+T%3BSridhara%2C+Rajeshwari%3BPazdur%2C+Richard%3BMcKee%2C+Amy+E&rft.aulast=Janne&rft.aufirst=Pasi&rft.date=2016-06-01&rft.volume=22&rft.issue=11&rft.spage=2613&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-2643 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Life cycle; Drug development; Oncology; Drugs; Clinical trials; Antitumor agents; Cancer DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-2643 ER - TY - JOUR T1 - Comparison of Channel Methods and Observer Models for the Task-Based Assessment of Multi-Projection Imaging in the Presence of Structured Anatomical Noise AN - 1808700392; PQ0003274370 AB - Although Laguerre-Gauss (LG) channels are often used for the task-based assessment of multi-projection imaging, LG channels may not be the most reliable in providing performance trends as a function of system or object parameters for all situations. Partial least squares (PLS) channels are more flexible in adapting to background and signal data statistics and were shown to be more efficient for detection tasks involving 2D non-Gaussian random backgrounds (Witten [etal], 2010). In this work, we investigate ways of incorporating spatial correlations in the multi-projection data space using 2D LG channels and two implementations of PLS in the channelized version of the 3D projection Hotelling observer (Park [etal], 2010) (3Dp CHO). Our task is to detect spherical and elliptical 3D signals in the angular projections of a structured breast phantom ensemble. The single PLS (sPLS) incorporates the spatial correlation within each projection, whereas the combined PLS (cPLS) incorporates the spatial correlations both within each of and across the projections. The 3Dp CHO-R indirectly incorporates the spatial correlation from the response space (R), whereas the 3Dp CHO-C from the channel space (C). The 3Dp CHO-R-sPLS has potential to be a good surrogate observer when either sample size is small or one training set is used for training both PLS channels and observer. So does the 3Dp CHO-C-cPLS when the sample size is large enough to have a good sized independent set for training PLS channels. Lastly a stack of 2D LG channels used as 3D channels in the CHO-C model showed the capability of incorporating the spatial correlation between the multiple angular projections. JF - IEEE Transactions on Medical Imaging AU - Park, Subok AU - Zhang, George AU - Myers, Kyle J AD - Division of Imaging, Diagnostics, and Software Reliability at the Center for Devices and Radiological Health (CDRH), US Food and Drug Administration (FDA), White Oak, Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1431 EP - 1442 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States VL - 35 IS - 6 SN - 0278-0062, 0278-0062 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Statistics KW - Parks KW - imaging KW - Models KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808700392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Medical+Imaging&rft.atitle=Comparison+of+Channel+Methods+and+Observer+Models+for+the+Task-Based+Assessment+of+Multi-Projection+Imaging+in+the+Presence+of+Structured+Anatomical+Noise&rft.au=Park%2C+Subok%3BZhang%2C+George%3BMyers%2C+Kyle+J&rft.aulast=Park&rft.aufirst=Subok&rft.date=2016-06-01&rft.volume=35&rft.issue=6&rft.spage=1431&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Medical+Imaging&rft.issn=02780062&rft_id=info:doi/10.1109%2FTMI.2016.2515027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Statistics; Data processing; Parks; imaging; Models DO - http://dx.doi.org/10.1109/TMI.2016.2515027 ER - TY - JOUR T1 - Lessons Learned: Dose Selection of Small Molecule-Targeted Oncology Drugs AN - 1808692151; PQ0003461290 AB - Evaluation of dose plays a critical role in a successful oncology development program. Typically for oncology agents, the first-in-man phase I dose-escalation trials are conducted to determine a maximum tolerated dose (MTD). This MTD is taken forward into subsequent trials to establish the safety and efficacy of the drug product. Although this approach was appropriate historically for cytotoxics, the application of MTD as the recommend phase II dose has been problematic for the newer small molecule-targeted oncology agents. Promising alternative approaches using dose and exposure exploration, including lessons learned from recent targeted oncology agent development and approvals, are summarized and discussed. Clin Cancer Res; 22(11); 2630-8. copyright 2016 AACR.See all articles in this CCR Focus section, "New Approaches for Optimizing Dosing of Anticancer Agents." JF - Clinical Cancer Research AU - Bullock, Julie M AU - Rahman, Atiqur AU - Liu, Qi AD - d3 Medicine LLC, Parsippany, New Jersey, qi.liu@fda.hhs.gov Y1 - 2016/06/01/ PY - 2016 DA - 2016 Jun 01 SP - 2630 EP - 2638 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 22 IS - 11 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Cytotoxicity KW - Oncology KW - Clinical trials KW - Antitumor agents KW - Drugs KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808692151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Lessons+Learned%3A+Dose+Selection+of+Small+Molecule-Targeted+Oncology+Drugs&rft.au=Bullock%2C+Julie+M%3BRahman%2C+Atiqur%3BLiu%2C+Qi&rft.aulast=Bullock&rft.aufirst=Julie&rft.date=2016-06-01&rft.volume=22&rft.issue=11&rft.spage=2630&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-2646 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Oncology; Drugs; Antitumor agents; Clinical trials; Cancer DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-2646 ER - TY - JOUR T1 - Rendering the 3 + 3 Design to Rest: More Efficient Approaches to Oncology Dose-Finding Trials in the Era of Targeted Therapy AN - 1808692130; PQ0003461301 AB - Selection of the maximum tolerated dose (MTD) as the recommended dose for registration trials based on a dose-escalation trial using variations of an MTD/3 + 3 design often occurs in the development of oncology products. The MTD/3 + 3 approach is not optimal and may result in recommended doses that are unacceptably toxic for many patients and in dose reduction/interruptions that might have an impact on effectiveness. Instead of the MTD/3 + 3 approach, the authors recommend an integrated approach. In this approach, typically an adaptive/Bayesian model provides a general framework to incorporate and make decisions for dose escalation based on nonclinical data, such as animal efficacy and toxicity data; clinical data, including pharmacokinetics/pharmacodynamics data; and dose/exposure-response data for efficacy and safety. To improve dose-ranging trials, model-based estimation, rather than hypothesis testing, should be used to maximize and integrate the information gathered across trials and doses. This approach may improve identification of optimal recommended doses, which can then be confirmed in registration trials. Clin Cancer Res; 22(11); 2623-9. copyright 2016 AACR.See all articles in this CCR Focus section, "New Approaches for Optimizing Dosing of Anticancer Agents." JF - Clinical Cancer Research AU - Nie, Lei AU - Rubin, Eric H AU - Mehrotra, Nitin AU - Pinheiro, Jose AU - Fernandes, Laura L AU - Roy, Amit AU - Bailey, Stuart AU - de Alwis, Dinesh P AD - Division of Biometrics V, OB/OTS/CDER/FDA, Silver Spring, Maryland, dinesh.de.alwis@merck.com Y1 - 2016/06/01/ PY - 2016 DA - 2016 Jun 01 SP - 2623 EP - 2629 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 22 IS - 11 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Mathematical models KW - Data processing KW - Bayesian analysis KW - Oncology KW - Toxicity KW - Antitumor agents KW - Clinical trials KW - Pharmacokinetics KW - Cancer KW - Decision making KW - Dose-response effects KW - Information processing KW - Pharmacodynamics KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808692130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Rendering+the+3+%2B+3+Design+to+Rest%3A+More+Efficient+Approaches+to+Oncology+Dose-Finding+Trials+in+the+Era+of+Targeted+Therapy&rft.au=Nie%2C+Lei%3BRubin%2C+Eric+H%3BMehrotra%2C+Nitin%3BPinheiro%2C+Jose%3BFernandes%2C+Laura+L%3BRoy%2C+Amit%3BBailey%2C+Stuart%3Bde+Alwis%2C+Dinesh+P&rft.aulast=Nie&rft.aufirst=Lei&rft.date=2016-06-01&rft.volume=22&rft.issue=11&rft.spage=2623&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-2644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Data processing; Mathematical models; Bayesian analysis; Oncology; Toxicity; Clinical trials; Antitumor agents; Cancer; Pharmacokinetics; Decision making; Information processing; Dose-response effects; Pharmacodynamics DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-2644 ER - TY - JOUR T1 - Developing Peptide Mimotopes of Capsular Polysaccharides and Lipopolysaccharides Protective Antigens of Pathogenic Burkholderia Bacteria AN - 1808685462; PQ0003328863 AB - Burkholderia pseudomallei (BP) and Burkholderia mallei (BM) are two species of pathogenic Burkholderia bacteria. Our laboratory previously identified four monoclonal antibodies (MAbs) that reacted against Burkholderia capsular polysaccharides (PS) and lipopolysaccharides (LPS) and effectively protected against a lethal dose of BP/BM infections in mice. In this study, we used phage display panning against three different phage peptide libraries to select phage clones specifically recognized by each of the four protective MAbs. After sequencing a total of 179 candidate phage clones, we examined in detail six selected phage clones carrying different peptide inserts for the specificity of binding by the respective target MAbs. Chemically synthesized peptides corresponding to those displayed by the six phage clones were conjugated to keyhole limpet hemocyanin carrier protein and tested for their binding specificity to the respective protective MAbs. The study revealed that four of the six peptides, all derived from the library displaying dodecapeptides, functioned well as "mimotopes" of Burkholderia PS and LPS as demonstrated by a high degree of specific competition against the binding of three protective MAbs to BP and BM. Our results suggest that the four selected peptide mimics corresponding to PS/LPS protective antigens of BP and BM could potentially be developed into peptide vaccines against pathogenic Burkholderia bacteria. JF - Monoclonal Antibodies in Immunodiagnosis and Immunotherapy AU - Guo, Pengfei AU - Zhang, Jing AU - Tsai, Shien AU - Li, Bingjie AU - Lo, Shyh-Ching AD - Tissue Microbiology Laboratory, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 125 EP - 134 PB - Mary Ann Liebert, Inc., 2 Madison Ave Larchmont NY 10538-1962 United States VL - 35 IS - 3 SN - 2167-9436, 2167-9436 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Burkholderia pseudomallei KW - Bacteria KW - Hemocyanins KW - Monoclonal antibodies KW - Immunotherapy KW - Phage display KW - protective antigen KW - Panning KW - Infection KW - Peptide libraries KW - Immunodiagnosis KW - Burkholderia mallei KW - Lipopolysaccharides KW - Vaccines KW - Competition KW - Capsular polysaccharides KW - Lethal dose KW - F 06905:Vaccines KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808685462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Monoclonal+Antibodies+in+Immunodiagnosis+and+Immunotherapy&rft.atitle=Developing+Peptide+Mimotopes+of+Capsular+Polysaccharides+and+Lipopolysaccharides+Protective+Antigens+of+Pathogenic+Burkholderia+Bacteria&rft.au=Guo%2C+Pengfei%3BZhang%2C+Jing%3BTsai%2C+Shien%3BLi%2C+Bingjie%3BLo%2C+Shyh-Ching&rft.aulast=Guo&rft.aufirst=Pengfei&rft.date=2016-06-01&rft.volume=35&rft.issue=3&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Monoclonal+Antibodies+in+Immunodiagnosis+and+Immunotherapy&rft.issn=21679436&rft_id=info:doi/10.1089%2Fmab.2015.0073 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 30 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Hemocyanins; Monoclonal antibodies; Immunotherapy; protective antigen; Phage display; Panning; Peptide libraries; Infection; Immunodiagnosis; Lipopolysaccharides; Vaccines; Capsular polysaccharides; Competition; Lethal dose; Burkholderia pseudomallei; Bacteria; Burkholderia mallei DO - http://dx.doi.org/10.1089/mab.2015.0073 ER - TY - JOUR T1 - Nonclinical Evaluations of Small-Molecule Oncology Drugs: Integration into Clinical Dose Optimization and Toxicity Management AN - 1808646549; PQ0003461289 AB - Multidisciplinary approaches that incorporate nonclinical pharmacologic and toxicologic characterization of small-molecule oncology drugs into clinical development programs may facilitate improved benefit-risk profiles and clinical toxicity management in patients. The performance of the current nonclinical safety-testing scheme was discussed, highlighting current strengths and areas for improvement. While current nonclinical testing appears to predict the clinical outcome where the prevalence of specific adverse effects are high, nonclinical testing becomes less reliable for predicting clinical adverse effects that occur infrequently, as with some kinase inhibitors. Although adverse effects associated with kinase inhibitors can often be predicted on the basis of target biology, drugs can be promiscuous and inhibit targets with poorly defined function and associated risks. Improvements in adverse effect databases and better characterization of the biologic activities of drug targets may enable better use of computational modeling approaches in predicting adverse effects with kinase inhibitors. Assessing safety of a lead candidate in parallel with other drug properties enables incorporation of a molecule's best features during chemical design, eliminates the worst molecules early, and permits timely investigation/characterization of toxicity mechanisms for identified liabilities. A safety lead optimization and candidate identification strategy that reduces intrinsic toxicity and metabolic risk and enhances selectivity can deliver selective kinase inhibitors that demonstrate on-target adverse effects identified nonclinically. Integrating clinical and nonclinical data during drug development can facilitate better identification and management of oncology drugs. Follow-up nonclinical studies may be used to better understand the risks in a given patient population and minimize or manage these risks more appropriately. Clin Cancer Res; 22(11); 2618-22. copyright 2016 AACR.See all articles in this CCR Focus section, "New Approaches for Optimizing Dosing of Anticancer Agents." JF - Clinical Cancer Research AU - Dambach, Donna M AU - Simpson, Natalie E AU - Jones, Thomas W AU - Brennan, Richard J AU - Pazdur, Richard AU - Palmby, Todd R AD - International Consortium for Innovation and Quality in Pharmaceutical Development DruSafe Leadership Group, Washington, District of Columbia, todd.palmby@fda.hhs.gov Y1 - 2016/06/01/ PY - 2016 DA - 2016 Jun 01 SP - 2618 EP - 2622 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 22 IS - 11 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Integration KW - Data processing KW - Drug development KW - Oncology KW - Toxicity KW - Computer applications KW - Drugs KW - Antitumor agents KW - Side effects KW - Cancer KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808646549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Nonclinical+Evaluations+of+Small-Molecule+Oncology+Drugs%3A+Integration+into+Clinical+Dose+Optimization+and+Toxicity+Management&rft.au=Dambach%2C+Donna+M%3BSimpson%2C+Natalie+E%3BJones%2C+Thomas+W%3BBrennan%2C+Richard+J%3BPazdur%2C+Richard%3BPalmby%2C+Todd+R&rft.aulast=Dambach&rft.aufirst=Donna&rft.date=2016-06-01&rft.volume=22&rft.issue=11&rft.spage=2618&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-2645 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Integration; Databases; Data processing; Oncology; Drug development; Toxicity; Computer applications; Antitumor agents; Drugs; Cancer; Side effects DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-2645 ER - TY - JOUR T1 - Evaluation of Molecular Methods for Serotyping Shigella flexneri AN - 1808612588; PQ0003246985 AB - Shigella flexneri can be phenotypically serotyped using antisera raised to type-specific somatic antigens and group factor antigens and genotypically serotyped using PCR targeting O-antigen synthesis or modification genes. The aim of this study was to evaluate a real-time PCR for serotyping S. flexneri and to use whole-genome sequencing (WGS) to investigate the phenotypic and genotypic serotype identifications. Of the 244 cultures tested retrospectively, 226 (92.6%) had concordant results between phenotypic serotyping and PCR. Seventy of the 244 isolates (including 15 of the 18 isolates where a serotype-PCR mismatch was identified) were whole-genome sequenced, and the serotype was derived from the genome. Discrepant results between the phenotypic and genotypic tests were attributed to insertions/deletions or point mutations identified in O-antigen synthesis or modification genes, rendering them dysfunctional; inconclusive serotyping results due to nonspecific cross-reactions; or novel genotypes. Phylogenetic analysis of the WGS data indicated that the serotype, regardless of whether it was phenotypically or genotypically determined, was a weak predictor of phylogenetic relationships between strains of S. flexneri. WGS data provided both genome-derived serotyping, thus supporting backward compatibility with historical data and facilitating data exchange in the community, and more robust and discriminatory typing at the single-nucleotide-polymorphism level. JF - Journal of Clinical Microbiology AU - Gentle, Amy AU - Ashton, Philip M AU - Dallman, Timothy J AU - Jenkins, Claire Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1456 EP - 1461 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 54 IS - 6 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Genomes KW - Antisera KW - Data processing KW - Serotypes KW - Cross-reaction KW - Shigella flexneri KW - Point mutation KW - Serotyping KW - Polymerase chain reaction KW - Genotypes KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808612588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+Molecular+Methods+for+Serotyping+Shigella+flexneri&rft.au=Gentle%2C+Amy%3BAshton%2C+Philip+M%3BDallman%2C+Timothy+J%3BJenkins%2C+Claire&rft.aulast=Gentle&rft.aufirst=Amy&rft.date=2016-06-01&rft.volume=54&rft.issue=6&rft.spage=1456&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.03386-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Number of references - 21 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Genomes; Phylogeny; Antisera; Serotypes; Data processing; Cross-reaction; Point mutation; Polymerase chain reaction; Serotyping; Genotypes; Shigella flexneri DO - http://dx.doi.org/10.1128/JCM.03386-15 ER - TY - JOUR T1 - The Lichtenberg Financial Decision Screening Scale (LFDSS): A new tool for assessing financial decision making and preventing financial exploitation AN - 1803283367 AB - One of the challenges in preventing the financial exploitation of older adults is that neither criminal justice nor noncriminal justice professionals are equipped to detect capacity deficits. Because decision-making capacity is a cornerstone assessment in cases of financial exploitation, effective instruments for measuring this capacity are essential. We introduce a new screening scale for financial decision making that can be administered to older adults. To explore the scale's implementation and assess construct validity, we conducted a pilot study of 29 older adults seen by APS (Adult Protective Services) workers and 79 seen by other professionals. Case examples are included. JF - Journal of Elder Abuse & Neglect AU - Lichtenberg, Peter A AU - Ficker, Lisa AU - Rahman-Filipiak, Analise AU - Tatro, Ron AU - Farrell, Cynthia AU - Speir, James J AU - Mall, Sanford J AU - Simasko, Patrick AU - Collens, Howard H AU - Jackman, John Daniel AD - Institute of Gerontology, Wayne State University, Detroit, Michigan, USA; Department of Psychology, Wayne State University, Detroit, Michigan, USA ; Institute of Gerontology, Wayne State University, Detroit, Michigan, USA ; Center for Elder Rights Advocacy, Elder Law of Michigan, Lansing, Michigan, USA ; Aging and Adult Services, Adult Protective Services, State of Michigan Department of Health and Human Services, Lansing, Michigan, USA ; Speir Financial Services, Southfield, Michigan, USA ; Mall, Malisow and Cooney, PC, Farmington Hills, Michigan, USA ; Simasko and Simasko Law Firm, Mount Clemens, Michigan, USA ; Galloway and Collens, PLLC, Huntington Woods, Michigan, USA ; Private Practice Cardiologist (Ret.), Tyler, Texas, USA ; Institute of Gerontology, Wayne State University, Detroit, Michigan, USA; Department of Psychology, Wayne State University, Detroit, Michigan, USA Y1 - 2016///Jun/Jul PY - 2016 DA - Jun/Jul 2016 SP - 134 EP - 151 CY - London PB - Taylor & Francis Group VL - 28 IS - 3 SN - 0894-6566 KW - Gerontology And Geriatrics KW - Financial decision making KW - financial exploitation KW - financial judgment KW - protective services KW - Decision making KW - Older people KW - Decision Making KW - Justice KW - Workers KW - Elderly KW - Criminal Justice KW - Tests KW - Exploitation KW - 2190:social problems and social welfare; victimology (rape, family violence, & child abuse) KW - 6143:child & family welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1803283367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Elder+Abuse+%26+Neglect&rft.atitle=The+Lichtenberg+Financial+Decision+Screening+Scale+%28LFDSS%29%3A+A+new+tool+for+assessing+financial+decision+making+and+preventing+financial+exploitation&rft.au=Lichtenberg%2C+Peter+A%3BFicker%2C+Lisa%3BRahman-Filipiak%2C+Analise%3BTatro%2C+Ron%3BFarrell%2C+Cynthia%3BSpeir%2C+James+J%3BMall%2C+Sanford+J%3BSimasko%2C+Patrick%3BCollens%2C+Howard+H%3BJackman%2C+John+Daniel&rft.aulast=Lichtenberg&rft.aufirst=Peter&rft.date=2016-06-01&rft.volume=28&rft.issue=3&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Journal+of+Elder+Abuse+%26+Neglect&rft.issn=08946566&rft_id=info:doi/10.1080%2F08946566.2016.1168333 LA - English DB - Social Services Abstracts; Sociological Abstracts N1 - Copyright - © 2016 Taylor & Francis N1 - Last updated - 2016-12-05 DO - http://dx.doi.org/10.1080/08946566.2016.1168333 ER - TY - JOUR T1 - Randomized Controlled Trial of Home-Based Hormonal Contraceptive Dispensing for Women At Risk of Unintended Pregnancy AN - 1796911276 AB - CONTEXT Women frequently experience barriers to obtaining effective contraceptives from clinic-based providers. Allowing nurses to dispense hormonal methods during home visits may be a way to reduce barriers and improve -effective contraceptive use. METHODS Between 2009 and 2013, a sample of 337 low-income, pregnant clients of a nurse home-visit program in Washington State were randomly selected to receive either usual care or enhanced care in which nurses were permitted to provide hormonal contraceptives postpartum. Participants were surveyed at baseline and every three months postpartum for up to two years. Longitudinal Poisson mixed-effects regression analysis was used to examine group differences in gaps in effective contraceptive use, and survival analysis was used to examine time until a subsequent pregnancy. RESULTS Compared with usual care participants, enhanced care participants had an average of 9.6 fewer days not covered by effective contraceptive use during the 90 days following a first birth (52.6 vs. 62.2). By six months postpartum, 50% of usual care participants and 39% of enhanced care participants were using a long-acting reversible contraceptive (LARC). In analyses excluding LARC use, enhanced care participants had an average of 14.2 fewer days not covered by effective contraceptive use 0-3 months postpartum (65.0 vs. 79.2) and 15.7 fewer uncovered days 4-6 months postpartum (39.2 vs. 54.9). CONCLUSION Home dispensing of hormonal contraceptives may improve women's postpartum contraceptive use and should be explored as an intervention in communities where contraceptives are not easily accessible. JF - Perspectives on Sexual and Reproductive Health AU - Melnick, Alan L AU - Rdesinski, Rebecca E AU - Marino, Miguel AU - Jacob-Files, Elizabeth AU - Gipson, Teresa AU - Kuyl, Marni AU - Dexter, Eve AU - Olds, David AD - Department of Family Medicine, Oregon Health & Science University, Portland ; Qualitative health research consultant, BJF Research, Seattle ; Department of Health and Human Services, Hillsboro, OR ; University of Colorado, Aurora Y1 - 2016/06// PY - 2016 DA - Jun 2016 SP - 93 EP - 99 CY - New York PB - Wiley Subscription Services, Inc. VL - 48 IS - 2 SN - 1538-6341 KW - Medical Sciences--Obstetrics And Gynecology KW - Birth control KW - Survival analysis KW - Feet KW - Risk factors KW - Reversible KW - At risk KW - First born KW - Home based KW - Care KW - Pregnancy KW - Contraceptives KW - Domiciliary visits KW - Postpartum women KW - Pregnant women KW - Analysis KW - Nurses KW - Unwanted pregnancy KW - Childbirth KW - Low income people UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1796911276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perspectives+on+Sexual+and+Reproductive+Health&rft.atitle=Randomized+Controlled+Trial+of+Home-Based+Hormonal+Contraceptive+Dispensing+for+Women+At+Risk+of+Unintended+Pregnancy&rft.au=Melnick%2C+Alan+L%3BRdesinski%2C+Rebecca+E%3BMarino%2C+Miguel%3BJacob-Files%2C+Elizabeth%3BGipson%2C+Teresa%3BKuyl%2C+Marni%3BDexter%2C+Eve%3BOlds%2C+David&rft.aulast=Melnick&rft.aufirst=Alan&rft.date=2016-06-01&rft.volume=48&rft.issue=2&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Perspectives+on+Sexual+and+Reproductive+Health&rft.issn=15386341&rft_id=info:doi/10.1363%2F48e9816 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright © 2016 by the Guttmacher Institute N1 - Last updated - 2016-06-23 DO - http://dx.doi.org/10.1363/48e9816 ER - TY - JOUR T1 - Soy-Based Infant Formula Feeding and Ultrasound-Detected Uterine Fibroids among Young African-American Women with No Prior Clinical Diagnosis of Fibroids. AN - 1793909568; 26565393 AB - Early-life soy phytoestrogen exposure has been shown in Eker rats to increase uterine fibroid incidence in adulthood. Two large epidemiologic cohorts have provided some support for increased fibroid risk with infant soy formula feeding in women, but both cohorts relied on self-report of clinically diagnosed fibroids. We evaluated the relationship between infant soy formula feeding and ultrasound-detected fibroids. The Study of Environment, Lifestyle & Fibroids (SELF) is an ongoing cohort study of 1,696 African-American women ages 23-34 years with baseline ultrasound screening to detect and measure fibroids ≥ 0.5 cm in diameter. Questionnaire data on soy formula feeding during infancy was ascertained for 1,553 participants (89% based on mother's report), of whom 345 were found to have fibroids. We estimated the association between soy formula feeding and fibroid prevalence and tumor number using log-binomial regression. Among those with fibroids, we compared fibroid size between soy formula-exposed and unexposed women using multivariable linear regression. We did not observe an association between soy formula feeding and fibroid prevalence [adjusted prevalence ratio (aPR) 0.9, 95% CI: 0.7, 1.3]. Nor were exposed women with fibroids more likely to have ≥ 2 tumors than unexposed women with fibroids (aPR 1.0, 95% CI: 0.7, 1.6). However, exposed women with fibroids had significantly larger fibroids than unexposed women with fibroids. On average, soy formula feeding was associated with a 32% increase in the diameter of the largest fibroid (95% CI: 6%, 65%) and a 127% increase in total tumor volume (95% CI: 12%, 358%). Our observation that women fed soy formula as infants have larger fibroids than unexposed women provides further support for persistent effects of early life phytoestrogen exposure on the uterus. Upson K, Harmon QE, Baird DD. 2016. Soy-based infant formula feeding and ultrasound-detected uterine fibroids among young African-American women with no prior clinical diagnosis of fibroids. Environ Health Perspect 124:769-775; http://dx.doi.org/10.1289/ehp.1510082. JF - Environmental health perspectives AU - Upson, Kristen AU - Harmon, Quaker E AU - Baird, Donna D AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 769 EP - 775 VL - 124 IS - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1793909568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Soy-Based+Infant+Formula+Feeding+and+Ultrasound-Detected+Uterine+Fibroids+among+Young+African-American+Women+with+No+Prior+Clinical+Diagnosis+of+Fibroids.&rft.au=Upson%2C+Kristen%3BHarmon%2C+Quaker+E%3BBaird%2C+Donna+D&rft.aulast=Upson&rft.aufirst=Kristen&rft.date=2016-06-01&rft.volume=124&rft.issue=6&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1510082 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1510082 ER - TY - JOUR T1 - Effects of letrozole on breast cancer micro-metastatic tumor growth in bone and lung in mice inoculated with murine 4T1 cells. AN - 1792774213; 27209469 AB - Breast cancer (BC) is the leading cancer in women worldwide. Metastasis occurs in stage IV BC with bone and lung being common metastatic sites. Here we evaluate the effects of the aromatase inhibitor letrozole on BC micro-metastatic tumor growth in bone and lung metastasis in intact and ovariectomized (OVX) mice with murine estrogen receptor negative (ER-) BC cells inoculated in tibia. Forty-eight BALB/c mice were randomly assigned to one of four groups: OVX, OVX + Letrozole, Intact, and Intact + Letrozole, and injected with 4T1 cells intra-tibially. Letrozole was subcutaneously injected daily for 23 days at a dose of 1.75 µg/g body weight. Tumor progression was monitored by bioluminescence imaging (BLI). Following necropsy, inoculated tibiae were scanned via µCT and bone response to tumor was scored from 0 (no ectopic mineralization/osteolysis) to 5 (extensive ectopic mineralization/osteolysis). OVX mice had higher tibial pathology scores indicative of more extensive bone destruction than intact mice, irrespective of letrozole treatment. Letrozole decreased serum estradiol levels and reduced lung surface tumor numbers in intact animals. Furthermore, mice receiving letrozole had significantly fewer tumor colonies and fewer proliferative cells in the lung than OVX and intact controls based on H&E and Ki-67 staining, respectively. In conclusion, BC-inoculated OVX animals had higher tibia pathology scores than BC-inoculated intact animals and letrozole reduced BC metastases to lungs. These findings suggest that, by lowering systemic estrogen level and/or by interacting with the host organ, the aromatase inhibitor letrozole has the potential to reduce ER- BC metastasis to lung. JF - Clinical & experimental metastasis AU - Wang, Wendan AU - Belosay, Aashvini AU - Yang, Xujuan AU - Hartman, James A AU - Song, Huaxin AU - Iwaniec, Urszula T AU - Turner, Russell T AU - Churchwell, Mona I AU - Doerge, Daniel R AU - Helferich, William G AD - Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 574 Bevier Hall, 905 South Goodwin Avenue, Urbana, IL, 61801, USA. ; Health Sciences Center, School of Nursing, Texas Tech University, Lubbock, TX, USA. ; Skeletal Biology Laboratory, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. ; Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, 574 Bevier Hall, 905 South Goodwin Avenue, Urbana, IL, 61801, USA. helferic@illinois.edu. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 475 EP - 485 VL - 33 IS - 5 KW - Index Medicus KW - Lung metastases KW - Aromatase inhibitor letrozole KW - Bioluminescence imaging KW - Breast cancer KW - Ovariectomy KW - Micro-metastatic bone tumor KW - µCT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1792774213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+%26+experimental+metastasis&rft.atitle=Effects+of+letrozole+on+breast+cancer+micro-metastatic+tumor+growth+in+bone+and+lung+in+mice+inoculated+with+murine+4T1+cells.&rft.au=Wang%2C+Wendan%3BBelosay%2C+Aashvini%3BYang%2C+Xujuan%3BHartman%2C+James+A%3BSong%2C+Huaxin%3BIwaniec%2C+Urszula+T%3BTurner%2C+Russell+T%3BChurchwell%2C+Mona+I%3BDoerge%2C+Daniel+R%3BHelferich%2C+William+G&rft.aulast=Wang&rft.aufirst=Wendan&rft.date=2016-06-01&rft.volume=33&rft.issue=5&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Clinical+%26+experimental+metastasis&rft.issn=1573-7276&rft_id=info:doi/10.1007%2Fs10585-016-9792-z LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10585-016-9792-z ER - TY - JOUR T1 - Proposed Mode of Action for Acrolein Respiratory Toxicity Associated with Inhaled Tobacco Smoke. AN - 1792379060; 26969371 AB - This article presents a mode of action (MOA) analysis that identifies key mechanisms in the respiratory toxicity of inhaled acrolein and proposes key acrolein-related toxic events resulting from the inhalation of tobacco smoke. Smoking causes chronic obstructive pulmonary disorder (COPD) and acrolein has been previously linked to the majority of smoking-induced noncancer respiratory toxicity. In contrast to previous MOA analyses for acrolein, this MOA focuses on the toxicity of acrolein in the lower respiratory system, reflecting the exposure that smokers experience upon tobacco smoke inhalation. The key mechanisms of acrolein toxicity identified in this proposed MOA include (1) acrolein chemical reactivity with proteins and other macromolecules of cells lining the respiratory tract, (2) cellular oxidative stress, including compromise of the important anti-oxidant glutathione, (3) chronic inflammation, (4) necrotic cell death leading to a feedback loop where necrosis-induced inflammation leads to more necrosis and oxidative damage and vice versa, (5) tissue remodeling and destruction, and (6) loss of lung elasticity and enlarged lung airspaces. From these mechanisms, the proposed MOA analysis identifies the key cellular processes in acrolein respiratory toxicity that consistently occur with the development of COPD: inflammation and necrosis in the middle and lower regions of the respiratory tract. Moreover, the acrolein exposures that occur as a result of smoking are well above exposures that induce both inflammation and necrosis in laboratory animals, highlighting the importance of the role of acrolein in smoking-related respiratory disease. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Yeager, R Philip AU - Kushman, Mary AU - Chemerynski, Susan AU - Weil, Roxana AU - Fu, Xin AU - White, Marcella AU - Callahan-Lyon, Priscilla AU - Rosenfeldt, Hans AD - *Division of Nonclinical Science, Center for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland 20993; ; Division of Regulatory Project Management, Center for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland 20993; and. ; Division of Individual Health Science, Center for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland 20993. ; *Division of Nonclinical Science, Center for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland 20993; *Division of Nonclinical Science, Center for Tobacco Products, US Food and Drug Administration, Silver Spring, Maryland 20993; hans.rosenfeldt@fda.hhs.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 347 EP - 364 VL - 151 IS - 2 KW - Index Medicus KW - inhalation KW - tobacco smoke KW - mode of action KW - respiratory toxicity. KW - acrolein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1792379060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Proposed+Mode+of+Action+for+Acrolein+Respiratory+Toxicity+Associated+with+Inhaled+Tobacco+Smoke.&rft.au=Yeager%2C+R+Philip%3BKushman%2C+Mary%3BChemerynski%2C+Susan%3BWeil%2C+Roxana%3BFu%2C+Xin%3BWhite%2C+Marcella%3BCallahan-Lyon%2C+Priscilla%3BRosenfeldt%2C+Hans&rft.aulast=Yeager&rft.aufirst=R&rft.date=2016-06-01&rft.volume=151&rft.issue=2&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw051 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw051 ER - TY - JOUR T1 - Subchronic exposures to fungal bioaerosols promotes allergic pulmonary inflammation in naïve mice. AN - 1792375085; 26892490 AB - Epidemiological surveys indicate that occupants of mold contaminated environments are at increased risk of respiratory symptoms. The immunological mechanisms associated with these responses require further characterization. The aim of this study was to characterize the immunotoxicological outcomes following repeated inhalation of dry Aspergillus fumigatus spores aerosolized at concentrations potentially encountered in contaminated indoor environments. Aspergillus fumigatus spores were delivered to the lungs of naïve BALB/cJ mice housed in a multi-animal nose-only chamber twice a week for a period of 13 weeks. Mice were evaluated at 24 and 48 h post-exposure for histopathological changes in lung architecture, recruitment of specific immune cells to the airways, and serum antibody responses. Germinating A. fumigatus spores were observed in lungs along with persistent fungal debris in the perivascular regions of the lungs. Repeated exposures promoted pleocellular infiltration with concomitant epithelial mucus hypersecretion, goblet cell metaplasia, subepithelial fibrosis and enhanced airway hyperreactivity. Cellular infiltration in airways was predominated by CD4(+) T cells expressing the pro-allergic cytokine IL-13. Furthermore, our studies show that antifungal T cell responses (IFN-γ(+) or IL-17A(+) ) co-expressed IL-13, revealing a novel mechanism for the dysregulated immune response to inhaled fungi. Total IgE production was augmented in animals repeatedly exposed to A. fumigatus. Repeated inhalation of fungal aerosols resulted in significant pulmonary pathology mediated by dynamic shifts in specific immune populations and their cytokines. These studies provide novel insights into the immunological mechanisms and targets that govern the health outcomes that result from repeated inhalation of fungal bioaerosols in contaminated environments. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology AU - Nayak, A P AU - Green, B J AU - Lemons, A R AU - Marshall, N B AU - Goldsmith, W T AU - Kashon, M L AU - Anderson, S E AU - Germolec, D R AU - Beezhold, D H AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 861 EP - 870 VL - 46 IS - 6 KW - Index Medicus KW - fungi KW - subchronic KW - Aspergillus fumigatus KW - asthma KW - immunotoxicity KW - allergy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1792375085?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+experimental+allergy+%3A+journal+of+the+British+Society+for+Allergy+and+Clinical+Immunology&rft.atitle=Subchronic+exposures+to+fungal+bioaerosols+promotes+allergic+pulmonary+inflammation+in+na%C3%AFve+mice.&rft.au=Nayak%2C+A+P%3BGreen%2C+B+J%3BLemons%2C+A+R%3BMarshall%2C+N+B%3BGoldsmith%2C+W+T%3BKashon%2C+M+L%3BAnderson%2C+S+E%3BGermolec%2C+D+R%3BBeezhold%2C+D+H&rft.aulast=Nayak&rft.aufirst=A&rft.date=2016-06-01&rft.volume=46&rft.issue=6&rft.spage=861&rft.isbn=&rft.btitle=&rft.title=Clinical+and+experimental+allergy+%3A+journal+of+the+British+Society+for+Allergy+and+Clinical+Immunology&rft.issn=1365-2222&rft_id=info:doi/10.1111%2Fcea.12724 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Immunol. 2012 Oct 1;189(7):3653-60 [22933634] Eur J Immunol. 2012 Sep;42(9):2322-8 [22684943] J Proteome Res. 2013 Jun 7;12(6):2552-70 [23656496] Pediatr Allergy Immunol. 2013 Nov;24(7):697-703 [24112429] J Allergy Clin Immunol. 2013 Nov;132(5):1194-1204.e2 [24060272] Nat Commun. 2014;5:3753 [24796415] PLoS One. 2014;9(10):e109855 [25340353] Environ Health Perspect. 2015 Jan;123(1):6-20 [25303775] Nat Immunol. 2015 Feb;16(2):161-9 [25531830] Indoor Air. 2015 Apr;25(2):125-56 [25601374] J Allergy Clin Immunol. 2002 Aug;110(2):285-92 [12170270] J Allergy Clin Immunol. 2003 Feb;111(2):285-9 [12589346] Annu Rev Immunol. 2003;21:425-56 [12615888] J Occup Environ Med. 2003 May;45(5):470-8 [12762072] Cytometry A. 2004 Oct;61(2):170-77 [15382026] J Allergy Clin Immunol. 2006 Feb;117(2):473; author reply 474 [16461157] J Allergy Clin Immunol. 2006 Feb;117(2):326-33 [16514772] PLoS Pathog. 2005 Nov;1(3):e30 [16304610] J Allergy Clin Immunol. 2006 Oct;118(4):892-8 [17030243] J Clin Invest. 2007 Mar;117(3):530-8 [17332880] J Immunol Methods. 2007 Oct 31;327(1-2):63-74 [17716680] Nat Med. 2008 Mar;14(3):282-9 [18264109] Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L552-65 [18658273] Crit Rev Toxicol. 2009;39(10):799-864 [19863384] J Exp Med. 2010 Oct 25;207(11):2479-91 [20921287] Med Mycol. 2010 Dec;48(8):1056-65 [20482452] Infect Immun. 2011 Jan;79(1):125-35 [21041495] Fungal Biol. 2011 Jan;115(1):21-9 [21215951] J Allergy Clin Immunol. 2011 Jul;128(1):192-201.e6 [21601259] Clin Vaccine Immunol. 2011 Sep;18(9):1568-76 [21734068] J Immunol. 2012 Feb 1;188(3):1503-13 [22198948] J Allergy Clin Immunol. 2012 Feb;129(2):280-91; quiz 292-3 [22284927] Clin Exp Allergy. 2012 May;42(5):782-91 [22515394] Toxicol Sci. 2012 Jun;127(2):371-81 [22403157] J Allergy Clin Immunol. 2012 Jun;129(6):1438-49; quiz1450-1 [22657405] Nat Rev Immunol. 2013 Feb;13(2):145-9 [23348417] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/cea.12724 ER - TY - JOUR T1 - Pharmacokinetics of isoflavones from soy infant formula in neonatal and adult rhesus monkeys AN - 1790968816; PQ0003116654 AB - Consumption of soy infant formula represents a unique exposure scenario in which developing children ingest a mixture of endocrine-active isoflavones along with a substantial portion of daily nutrition. Genistein and daidzein were administered as glucoside conjugates to neonatal rhesus monkeys in a fortified commercial soy formula at 5, 35, and 70 days after birth. A single gavage dosing with 10 mg/kg bw genistein and 6 mg/kg bw daidzein was chosen to represent the upper range of typical daily consumption and to facilitate complete pharmacokinetic measurements for aglycone and total isoflavones and equol. Adult monkeys were also gavaged with the same formula solution at 2.8 and 1.6 mg/kg bw genistein and daidzein, respectively, and by IV injection with isoflavone aglycones (5.2 and 3.2 mg/kg bw, respectively) to determine absolute bioavailability. Significant differences in internal exposure were observed between neonatal and adult monkeys, with higher values for dose-adjusted AUC and Cmax of the active aglycone isoflavones in neonates. The magnitude and frequency of equol production by the gut microbiome were also significantly greater in adults. These findings are consistent with immaturity of metabolic and/or physiological systems in developing non-human primates that reduces total clearance of soy isoflavones from the body. JF - Food and Chemical Toxicology AU - Doerge, Daniel R AU - Woodling, Kellie A AU - Churchwell, Mona I AU - Fleck, Stefanie C AU - Helferich, William G AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 165 EP - 176 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 92 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts; Environment Abstracts KW - Soy KW - Genistein KW - Daidzein KW - Rhesus monkey KW - Pharmacokinetics KW - Mass spectrometry KW - Neonatal KW - Infant formulas KW - Aglycones KW - Physiology KW - glucosides KW - Children KW - Primates KW - Nutrition KW - Isoflavones KW - daidzein KW - Soybeans KW - Birth KW - Bioavailability KW - Digestive tract KW - Macaca mulatta KW - Neonates KW - X 24320:Food Additives & Contaminants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790968816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Pharmacokinetics+of+isoflavones+from+soy+infant+formula+in+neonatal+and+adult+rhesus+monkeys&rft.au=Doerge%2C+Daniel+R%3BWoodling%2C+Kellie+A%3BChurchwell%2C+Mona+I%3BFleck%2C+Stefanie+C%3BHelferich%2C+William+G&rft.aulast=Doerge&rft.aufirst=Daniel&rft.date=2016-06-01&rft.volume=92&rft.issue=&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2016.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Aglycones; Infant formulas; Children; glucosides; Nutrition; Isoflavones; Pharmacokinetics; Soybeans; daidzein; Birth; Bioavailability; Digestive tract; Neonates; Genistein; Physiology; Primates; Macaca mulatta DO - http://dx.doi.org/10.1016/j.fct.2016.04.005 ER - TY - JOUR T1 - The role of US organic certifiers in organic hotspot formation AN - 1790964743; PQ0003042164 AB - The purpose of this paper is to investigate the formation of hotspots of organic operations (geographically close areas that have positively correlated high numbers of organic operations), paying particular attention to the role of the organic certifying agent. We analyze the association of county-level factors related to policy, economics, demographics and organic certifiers with the probability that a county is in a hotspot or coldspot (geographically close areas that have positively correlated low numbers of organic operations) of organic operations. The results suggest that a high presence of government run organic certifying agents, as well as a high presence of private organic certifying agents who provide outreach services, are both positively associated with the probability that a county belongs to a hotspot. Other factors, such as the level of property taxes and the distance of the county from the nearest interstate, are also significantly correlated with the probability that a county is in a hotspot. Understanding factors associated with organic hotspots is important given the surge in momentum in the organic industry and the concerns that demand for organic products may be outpacing domestic supply. In particular, understanding the role that certifiers play in the formation of organic hotspots is important, as certain services provided by certifiers may be indicative of the level of communication between organic operations and their communities. The results of this paper may encourage public institutions that approve and regulate organic certifiers to provide incentives for offering outreach services, and private institutions interested in promoting organic operations to work more closely with certifying agents as a means to boost organic hotspots. JF - Renewable Agriculture and Food Systems AU - Marasteanu, IJulia AU - Jaenicke, Edward C AD - Food and Drug Administration (formerly the Pennsylvania State University), 5100 Paint Branch Parkway # 1B056, College Park, MD 20740, USA, juliamarasteanu@gmail.com Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 230 EP - 245 PB - CAB International, Wallingford Oxon OX10 8DE United Kingdom VL - 31 IS - 3 SN - 1742-1705, 1742-1705 KW - Environment Abstracts KW - Demography KW - Taxation KW - Agriculture KW - Communications KW - Hot spots KW - Economics KW - Certification KW - Incentives KW - ENA 06:Food & Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790964743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Renewable+Agriculture+and+Food+Systems&rft.atitle=The+role+of+US+organic+certifiers+in+organic+hotspot+formation&rft.au=Marasteanu%2C+IJulia%3BJaenicke%2C+Edward+C&rft.aulast=Marasteanu&rft.aufirst=IJulia&rft.date=2016-06-01&rft.volume=31&rft.issue=3&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Renewable+Agriculture+and+Food+Systems&rft.issn=17421705&rft_id=info:doi/10.1017%2FS1742170515000149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Number of references - 27 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Agriculture; Taxation; Demography; Communications; Hot spots; Economics; Incentives; Certification DO - http://dx.doi.org/10.1017/S1742170515000149 ER - TY - JOUR T1 - Changes in bone mineral density over time by body mass index in the health ABC study AN - 1790952616; PQ0003135028 AB - Obesity appears protective against osteoporosis in cross-sectional studies. However, results from this longitudinal study found that obesity was associated with bone loss over time. Findings underscore the importance of looking at the longitudinal relationship, particularly given the increasing prevalence and duration of obesity among older adults. Cross-sectional studies have found a positive association between body mass index (BMI) and bone mineral density (BMD), but little is known about the longitudinal relationship in US older adults. We examined average annual rate of change in BMD by baseline BMI in the Health, Aging, and Body Composition Study. Repeated measurement of BMD was performed with dual-energy X-ray absorptiometry (DXA) at baseline and years 3, 5, 6, 8, and 10. Multivariate generalized estimating equations were used to predict mean BMD (femoral neck, total hip, and whole body) by baseline BMI (excluding underweight), adjusting for covariates. In the sample (n=2570), 43 % were overweight and 24 % were obese with a mean baseline femoral neck BMD of 0.743 g/cm super(2), hip BMD of 0.888 g/cm super(2), and whole-body BMD of 1.09 g/cm super(2). Change in total hip or whole-body BMD over time did not vary by BMI groups. However, obese older adults lost 0.003 g/cm super(2) of femoral neck BMD per year more compared with normal weight older adults (p<0.001). Femoral neck BMD change over time did not differ between the overweight and normal weight BMI groups (p=0.74). In year 10, adjusted femoral neck BMD ranged from 0.696 g/cm super(2) among obese, 0.709 g/cm super(2) among normal weight, and 0.719 g/cm super(2) among overweight older adults. Findings underscore the importance of looking at the longitudinal relationship between body composition and bone mineral density among older adults, indicating that high body mass may not be protective for bone loss over time. JF - Osteoporosis International AU - Lloyd, J T AU - Alley, DE AU - Hochberg, M C AU - Waldstein AU - Harris, T B AU - Kritchevsky, S B AU - Schwartz, A V AU - Strotmeyer, E S AU - Womack, C AU - Orwig, D L AD - Centers for Medicare and Medicaid Services, 7500 Security Blvd, WB-06-05, Baltimore, MD, 21244, USA, Jennifer.Lloyd@cms.hhs.gov Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 2109 EP - 2116 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 27 IS - 6 SN - 0937-941X, 0937-941X KW - Physical Education Index; Calcium & Calcified Tissue Abstracts KW - Obesity KW - Mathematical models KW - Body mass KW - Aging KW - Dual energy X-ray absorptiometry KW - Gerontology KW - Osteoporosis KW - Underweight KW - Adults KW - Femur KW - Neck KW - Hips KW - Bone mineral density KW - Body weight KW - Weight KW - Bone loss KW - Body mass index KW - Body composition KW - Hip KW - T 2025:Bone and Bone Diseases KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790952616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Osteoporosis+International&rft.atitle=Changes+in+bone+mineral+density+over+time+by+body+mass+index+in+the+health+ABC+study&rft.au=Lloyd%2C+J+T%3BAlley%2C+DE%3BHochberg%2C+M+C%3BWaldstein%3BHarris%2C+T+B%3BKritchevsky%2C+S+B%3BSchwartz%2C+A+V%3BStrotmeyer%2C+E+S%3BWomack%2C+C%3BOrwig%2C+D+L&rft.aulast=Lloyd&rft.aufirst=J&rft.date=2016-06-01&rft.volume=27&rft.issue=6&rft.spage=2109&rft.isbn=&rft.btitle=&rft.title=Osteoporosis+International&rft.issn=0937941X&rft_id=info:doi/10.1007%2Fs00198-016-3506-x LA - English DB - Physical Education Index N1 - Date revised - 2016-05-01 N1 - Number of references - 39 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Obesity; Bone mineral density; Weight; Body mass; Gerontology; Adults; Body composition; Neck; Hips; Mathematical models; Aging; Dual energy X-ray absorptiometry; Osteoporosis; Underweight; Femur; Body weight; Bone loss; Body mass index; Hip DO - http://dx.doi.org/10.1007/s00198-016-3506-x ER - TY - JOUR T1 - Maintaining a Safe Blood Supply in an Era of Emerging Pathogens AN - 1790941089; PQ0003120228 AB - Coming shortly after outbreaks of dengue and chikungunya virus in related locations, the recent outbreak of Zika virus in the southern part of the western hemisphere is yet another reminder that infectious pathogens continue to emerge rapidly and can adversely affect public health, including the safety of the blood supply. In response to Zika virus, public health measures that rely largely on donor deferral and sourcing of blood from non-outbreak areas until a blood donor screening test becomes available have been implemented to address the safety of the blood supply in the United States. However, a more universal approach to ensuring blood safety in the setting of rapidly emerging infectious diseases is needed. JF - Journal of Infectious Diseases AU - Marks, Peter W AU - Epstein, Jay S AU - Borio, Luciana L AD - Food and Drug Administration, Silver Spring, Maryland, luciana.borio@fda.hhs.gov Y1 - 2016/06/01/ PY - 2016 DA - 2016 Jun 01 SP - 1676 EP - 1677 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 213 IS - 11 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts KW - blood safety KW - donor screening tests KW - emerging pathogens KW - pathogen-reduction KW - Zika virus KW - Blood donors KW - USA KW - Chikungunya virus KW - Infectious diseases KW - Dengue KW - Safety KW - Outbreaks KW - Pathogens KW - Public health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790941089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Maintaining+a+Safe+Blood+Supply+in+an+Era+of+Emerging+Pathogens&rft.au=Marks%2C+Peter+W%3BEpstein%2C+Jay+S%3BBorio%2C+Luciana+L&rft.aulast=Marks&rft.aufirst=Peter&rft.date=2016-06-01&rft.volume=213&rft.issue=11&rft.spage=1676&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiw089 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Blood donors; Infectious diseases; Dengue; Safety; Pathogens; Outbreaks; Public health; Chikungunya virus; Zika virus; USA DO - http://dx.doi.org/10.1093/infdis/jiw089 ER - TY - JOUR T1 - Hospital Readmission Rates in U.S. States: Are Readmissions Higher Where More Patients with Multiple Chronic Conditions Cluster? AN - 1790471449 AB - Research Objective This study examines small area variations in readmission rates to assess whether higher readmission rate in an area is associated with higher clusters of patients with multiple chronic conditions. Study Design The study uses hospital discharge data of adult (18+) patients in 6 U.S. states for 2009 from the Healthcare Cost and Utilization Project of the Agency for Healthcare Research and Quality, linked to contextual and provider data from Health Resources and Services Administration. A multivariate cross sectional design at primary care service area (PCSA) level is used. Principal Findings Adjusting for area characteristics, the readmission rates were significantly higher in PCSAs having higher proportions of patients with 2-3 chronic conditions and those with 4+ chronic conditions, compared with areas with a higher concentration of patients with 0-1 chronic conditions. Conclusions Using small area analysis, the study shows that areas with higher concentration of patients with increased comorbid conditions are more likely to have higher readmission rates. JF - Health Services Research AU - Basu, Jayasree AU - Avila, Rosa AU - Ricciardi, Richard AD - Agency for Health Care Research and Quality, Center for Evidence and Practice Improvement, Rockville, MD ; School of Public Health, Department of Health Services, University of Washington, Seattle, WA Y1 - 2016/06// PY - 2016 DA - Jun 2016 SP - 1135 EP - 1151 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 51 IS - 3 SN - 0017-9124 KW - Medical Sciences KW - Chronic sickness KW - Comorbidity KW - Conditions KW - Discharge KW - Health costs KW - Medical research KW - Primary health care KW - Readmission KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790471449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Hospital+Readmission+Rates+in+U.S.+States%3A+Are+Readmissions+Higher+Where+More+Patients+with+Multiple+Chronic+Conditions+Cluster%3F&rft.au=Basu%2C+Jayasree%3BAvila%2C+Rosa%3BRicciardi%2C+Richard&rft.aulast=Basu&rft.aufirst=Jayasree&rft.date=2016-06-01&rft.volume=51&rft.issue=3&rft.spage=1135&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12401 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2016-05-23 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1111/1475-6773.12401 ER - TY - JOUR T1 - New Evidence on What Works in Effective Public Reporting AN - 1790471345 AB - Objective To describe the current state of the public reporting field and provide guidance to public report producers based on the evidence. Principal Findings Public reports should address the questions and priorities that consumers actually have; present information credibly and in a way that is understood by the intended audience; reach the intended audience; and enable consumers to act on the information. Conclusions Public reports have advanced greatly in recent years, but there remains much room for improvement. Report producers should continually evaluate their reports and apply the latest evidence to maximize their usefulness and impact. JF - Health Services Research AU - Sandmeyer, Brent AU - Fraser, Irene AD - Agency for Healthcare Research and Quality, Center for Delivery, Organization and Markets, Washington, DC ; NORC at the University of Chicago, Chicago, IL Y1 - 2016/06// PY - 2016 DA - Jun 2016 SP - 1159 EP - 1166 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 51 IS - S2 SN - 0017-9124 KW - Medical Sciences KW - Consumers KW - Guidance KW - Usefulness KW - Reporting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790471345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=New+Evidence+on+What+Works+in+Effective+Public+Reporting&rft.au=Sandmeyer%2C+Brent%3BFraser%2C+Irene&rft.aulast=Sandmeyer&rft.aufirst=Brent&rft.date=2016-06-01&rft.volume=51&rft.issue=S2&rft.spage=1159&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12502 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © Health Research and Educational Trust N1 - Last updated - 2016-05-25 DO - http://dx.doi.org/10.1111/1475-6773.12502 ER - TY - JOUR T1 - Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity. AN - 1790454872; 26879463 AB - Statistical-based and expert rule-based models built using public domain mutagenicity knowledge and data are routinely used for computational (Q)SAR assessments of pharmaceutical impurities in line with the approach recommended in the ICH M7 guideline. Knowledge from proprietary corporate mutagenicity databases could be used to increase the predictive performance for selected chemical classes as well as expand the applicability domain of these (Q)SAR models. This paper outlines a mechanism for sharing knowledge without the release of proprietary data. Primary aromatic amine mutagenicity was selected as a case study because this chemical class is often encountered in pharmaceutical impurity analysis and mutagenicity of aromatic amines is currently difficult to predict. As part of this analysis, a series of aromatic amine substructures were defined and the number of mutagenic and non-mutagenic examples for each chemical substructure calculated across a series of public and proprietary mutagenicity databases. This information was pooled across all sources to identify structural classes that activate or deactivate aromatic amine mutagenicity. This structure activity knowledge, in combination with newly released primary aromatic amine data, was incorporated into Leadscope's expert rule-based and statistical-based (Q)SAR models where increased predictive performance was demonstrated. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Ahlberg, Ernst AU - Amberg, Alexander AU - Beilke, Lisa D AU - Bower, David AU - Cross, Kevin P AU - Custer, Laura AU - Ford, Kevin A AU - Van Gompel, Jacky AU - Harvey, James AU - Honma, Masamitsu AU - Jolly, Robert AU - Joossens, Elisabeth AU - Kemper, Raymond A AU - Kenyon, Michelle AU - Kruhlak, Naomi AU - Kuhnke, Lara AU - Leavitt, Penny AU - Naven, Russell AU - Neilan, Claire AU - Quigley, Donald P AU - Shuey, Dana AU - Spirkl, Hans-Peter AU - Stavitskaya, Lidiya AU - Teasdale, Andrew AU - White, Angela AU - Wichard, Joerg AU - Zwickl, Craig AU - Myatt, Glenn J AD - AstraZeneca, Mölndal, Sweden. ; Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany. ; Toxicology Solutions, San Diego, CA, USA. ; Leadscope, Columbus, OH, USA. ; Bristol-Myers Squibb Co., New Brunswick, NJ, USA. ; Genentech, South San Francisco, USA. ; Janssen Research and Development, Beerse, Belgium. ; GlaxoSmithKline, Ware, UK. ; National Institute of Health Sciences, Tokyo, Japan. ; Eli Lilly and Company, Indianapolis, IN, USA. ; European Commission Joint Research Centre, Ispra, Italy. ; Vertex, Boston, MA, USA. ; Pfizer, Groton, CT, USA. ; FDA Center for Drug Evaluation and Research, Silver Spring, MD, USA. ; Bayer HealthCare, Berlin, Germany. ; Incyte Corporation, Wilmington, DE, USA. ; AstraZeneca, Cheshire, England, UK. ; Leadscope, Columbus, OH, USA. Electronic address: gmyatt@leadscope.com. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 1 EP - 12 VL - 77 KW - Index Medicus KW - Pharmaceutical impurities KW - ICH M7 KW - Mutagenicity KW - (Q)SAR KW - Aromatic amines KW - SAR fingerprint UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790454872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Extending+%28Q%29SARs+to+incorporate+proprietary+knowledge+for+regulatory+purposes%3A+A+case+study+using+aromatic+amine+mutagenicity.&rft.au=Ahlberg%2C+Ernst%3BAmberg%2C+Alexander%3BBeilke%2C+Lisa+D%3BBower%2C+David%3BCross%2C+Kevin+P%3BCuster%2C+Laura%3BFord%2C+Kevin+A%3BVan+Gompel%2C+Jacky%3BHarvey%2C+James%3BHonma%2C+Masamitsu%3BJolly%2C+Robert%3BJoossens%2C+Elisabeth%3BKemper%2C+Raymond+A%3BKenyon%2C+Michelle%3BKruhlak%2C+Naomi%3BKuhnke%2C+Lara%3BLeavitt%2C+Penny%3BNaven%2C+Russell%3BNeilan%2C+Claire%3BQuigley%2C+Donald+P%3BShuey%2C+Dana%3BSpirkl%2C+Hans-Peter%3BStavitskaya%2C+Lidiya%3BTeasdale%2C+Andrew%3BWhite%2C+Angela%3BWichard%2C+Joerg%3BZwickl%2C+Craig%3BMyatt%2C+Glenn+J&rft.aulast=Ahlberg&rft.aufirst=Ernst&rft.date=2016-06-01&rft.volume=77&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.02.003 ER - TY - JOUR T1 - Micro-CT imaging: Developing criteria for examining fetal skeletons in regulatory developmental toxicology studies - A workshop report. AN - 1790453528; 26930635 AB - During the past two decades the use and refinements of imaging modalities have markedly increased making it possible to image embryos and fetuses used in pivotal nonclinical studies submitted to regulatory agencies. Implementing these technologies into the Good Laboratory Practice environment requires rigorous testing, validation, and documentation to ensure the reproducibility of data. A workshop on current practices and regulatory requirements was held with the goal of defining minimal criteria for the proper implementation of these technologies and subsequent submission to regulatory agencies. Micro-computed tomography (micro-CT) is especially well suited for high-throughput evaluations, and is gaining popularity to evaluate fetal skeletons to assess the potential developmental toxicity of test agents. This workshop was convened to help scientists in the developmental toxicology field understand and apply micro-CT technology to nonclinical toxicology studies and facilitate the regulatory acceptance of imaging data. Presentations and workshop discussions covered: (1) principles of micro-CT fetal imaging; (2) concordance of findings with conventional skeletal evaluations; and (3) regulatory requirements for validating the system. Establishing these requirements for micro-CT examination can provide a path forward for laboratories considering implementing this technology and provide regulatory agencies with a basis to consider the acceptability of data generated via this technology. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Solomon, Howard M AU - Makris, Susan L AU - Alsaid, Hasan AU - Bermudez, Oscar AU - Beyer, Bruce K AU - Chen, Antong AU - Chen, Connie L AU - Chen, Zhou AU - Chmielewski, Gary AU - DeLise, Anthony M AU - de Schaepdrijver, Luc AU - Dogdas, Belma AU - French, Julian AU - Harrouk, Wafa AU - Helfgott, Jonathan AU - Henkelman, R Mark AU - Hesterman, Jacob AU - Hew, Kok-Wah AU - Hoberman, Alan AU - Lo, Cecilia W AU - McDougal, Andrew AU - Minck, Daniel R AU - Scott, Lelia AU - Stewart, Jane AU - Sutherland, Vicki AU - Tatiparthi, Arun K AU - Winkelmann, Christopher T AU - Wise, L David AU - Wood, Sandra L AU - Ying, Xiaoyou AD - GlaxoSmithKline, King of Prussia, PA, United States. ; U.S. Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC, United States. Electronic address: makris.susan@epa.gov. ; ILSI Health and Environmental Sciences Institute, Washington, DC, United States. ; Sanofi U.S. Inc., Bridgewater, NJ, United States. ; Merck Research Laboratories, Kenilworth, NJ, United States. ; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Office of New Drugs, Silver Spring, MD, United States. ; Covance Laboratories, Greenfield, IN, United States. ; Novartis Pharmaceutical Corporation, East Hanover, NJ, United States. ; Janssen R&D, Beerse, Belgium. ; Morphology Consulting Ltd., Staffordshire, United Kingdom. ; Stage 2 Innovations, Framingham, MI, United States. ; The Hospital for Sick Children, University of Toronto, Toronto, Canada. ; InviCRO, Boston, MA, United States. ; Takeda Pharmaceutical Company, Deerfield, IL, United States. ; Charles River Laboratories, Preclinical Services, Horsham, PA, United States. ; University of Pittsburgh, Pittsburgh, PA, United States. ; ApconiX, Macclesfield, Cheshire, United Kingdom. ; National Toxicology Program/NIEHS, Research Triangle Park, NC, United States. ; Pfizer Worldwide Research & Development, La Jolla, CA, United States. ; Independent Teratologist, Philadelphia, PA, United States. ; Merck Research Laboratories, Upper Gwynedd, PA, United States. ; Sanofi U.S. Inc., Cambridge, MA, United States. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 100 EP - 108 VL - 77 KW - Index Medicus KW - Concordance criteria KW - Micro-CT KW - Developmental toxicology KW - GLP validation KW - Imaging KW - Skeletal evaluation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790453528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Micro-CT+imaging%3A+Developing+criteria+for+examining+fetal+skeletons+in+regulatory+developmental+toxicology+studies+-+A+workshop+report.&rft.au=Solomon%2C+Howard+M%3BMakris%2C+Susan+L%3BAlsaid%2C+Hasan%3BBermudez%2C+Oscar%3BBeyer%2C+Bruce+K%3BChen%2C+Antong%3BChen%2C+Connie+L%3BChen%2C+Zhou%3BChmielewski%2C+Gary%3BDeLise%2C+Anthony+M%3Bde+Schaepdrijver%2C+Luc%3BDogdas%2C+Belma%3BFrench%2C+Julian%3BHarrouk%2C+Wafa%3BHelfgott%2C+Jonathan%3BHenkelman%2C+R+Mark%3BHesterman%2C+Jacob%3BHew%2C+Kok-Wah%3BHoberman%2C+Alan%3BLo%2C+Cecilia+W%3BMcDougal%2C+Andrew%3BMinck%2C+Daniel+R%3BScott%2C+Lelia%3BStewart%2C+Jane%3BSutherland%2C+Vicki%3BTatiparthi%2C+Arun+K%3BWinkelmann%2C+Christopher+T%3BWise%2C+L+David%3BWood%2C+Sandra+L%3BYing%2C+Xiaoyou&rft.aulast=Solomon&rft.aufirst=Howard&rft.date=2016-06-01&rft.volume=77&rft.issue=&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.02.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.02.018 ER - TY - JOUR T1 - Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses. AN - 1790452965; 26877192 AB - The ICH M7 guideline describes a consistent approach to identify, categorize, and control DNA reactive, mutagenic, impurities in pharmaceutical products to limit the potential carcinogenic risk related to such impurities. This paper outlines a series of principles and procedures to consider when generating (Q)SAR assessments aligned with the ICH M7 guideline to be included in a regulatory submission. In the absence of adequate experimental data, the results from two complementary (Q)SAR methodologies may be combined to support an initial hazard classification. This may be followed by an assessment of additional information that serves as the basis for an expert review to support or refute the predictions. This paper elucidates scenarios where additional expert knowledge may be beneficial, what such an expert review may contain, and how the results and accompanying considerations may be documented. Furthermore, the use of these principles and procedures to yield a consistent and robust (Q)SAR-based argument to support impurity qualification for regulatory purposes is described in this manuscript. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Amberg, Alexander AU - Beilke, Lisa AU - Bercu, Joel AU - Bower, Dave AU - Brigo, Alessandro AU - Cross, Kevin P AU - Custer, Laura AU - Dobo, Krista AU - Dowdy, Eric AU - Ford, Kevin A AU - Glowienke, Susanne AU - Van Gompel, Jacky AU - Harvey, James AU - Hasselgren, Catrin AU - Honma, Masamitsu AU - Jolly, Robert AU - Kemper, Raymond AU - Kenyon, Michelle AU - Kruhlak, Naomi AU - Leavitt, Penny AU - Miller, Scott AU - Muster, Wolfgang AU - Nicolette, John AU - Plaper, Andreja AU - Powley, Mark AU - Quigley, Donald P AU - Reddy, M Vijayaraj AU - Spirkl, Hans-Peter AU - Stavitskaya, Lidiya AU - Teasdale, Andrew AU - Weiner, Sandy AU - Welch, Dennie S AU - White, Angela AU - Wichard, Joerg AU - Myatt, Glenn J AD - Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany. ; Toxicology Solutions, San Diego, CA, USA. ; Gilead, Foster City, CA, USA. ; Leadscope, Columbus, OH, USA. ; Roche Pharmaceutical Research & Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland. ; Bristol-Myers Squibb, New Brunswick, NJ, USA. ; Pfizer, Groton, CT, USA. ; Genentech, South San Francisco, USA. ; Novartis Institutes for Biomedical Research, Basel, Switzerland. ; Janssen, Beerse, Belgium. ; GlaxoSmithKline, Ware, Herts, UK. ; National Institute of Health Sciences, Tokyo, Japan. ; Eli Lilly and Company, Indianapolis, IN, USA. ; Vertex, Boston, MA, USA. ; FDA Center for Drug Evaluation and Research, Silver Spring, MD, USA. ; AbbVie Inc., North Chicago, IL, USA. ; KRKA, Novo Mesto, Slovenia. ; Merck Research Laboratories, West Point, PA, USA. ; AstraZeneca, Macclesfield, Cheshire, UK. ; Janssen, Spring House, PA, USA. ; Bayer HealthCare, Berlin, Germany. ; Leadscope, Columbus, OH, USA. Electronic address: gmyatt@leadscope.com. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 13 EP - 24 VL - 77 KW - Index Medicus KW - Toxicity databases KW - ICH M7 KW - Expert review KW - (Q)SAR KW - Impurities KW - Ames test KW - Mutagenic impurities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790452965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Principles+and+procedures+for+implementation+of+ICH+M7+recommended+%28Q%29SAR+analyses.&rft.au=Amberg%2C+Alexander%3BBeilke%2C+Lisa%3BBercu%2C+Joel%3BBower%2C+Dave%3BBrigo%2C+Alessandro%3BCross%2C+Kevin+P%3BCuster%2C+Laura%3BDobo%2C+Krista%3BDowdy%2C+Eric%3BFord%2C+Kevin+A%3BGlowienke%2C+Susanne%3BVan+Gompel%2C+Jacky%3BHarvey%2C+James%3BHasselgren%2C+Catrin%3BHonma%2C+Masamitsu%3BJolly%2C+Robert%3BKemper%2C+Raymond%3BKenyon%2C+Michelle%3BKruhlak%2C+Naomi%3BLeavitt%2C+Penny%3BMiller%2C+Scott%3BMuster%2C+Wolfgang%3BNicolette%2C+John%3BPlaper%2C+Andreja%3BPowley%2C+Mark%3BQuigley%2C+Donald+P%3BReddy%2C+M+Vijayaraj%3BSpirkl%2C+Hans-Peter%3BStavitskaya%2C+Lidiya%3BTeasdale%2C+Andrew%3BWeiner%2C+Sandy%3BWelch%2C+Dennie+S%3BWhite%2C+Angela%3BWichard%2C+Joerg%3BMyatt%2C+Glenn+J&rft.aulast=Amberg&rft.aufirst=Alexander&rft.date=2016-06-01&rft.volume=77&rft.issue=&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.02.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.02.004 ER - TY - JOUR T1 - Urine and serum biomonitoring of exposure to environmental estrogens I: Bisphenol A in pregnant women. AN - 1788226155; 27038865 AB - Despite its very low oral bioavailability and rapid elimination, multiple reports of unexpectedly high bisphenol A (BPA) concentrations in the serum of pregnant mothers or cord blood have raised questions about BPA exposures during pregnancy. Thirty healthy pregnant women recruited to the study were evaluated for total BPA exposure over a 30-h period comprising one-half day in the field and one day in a clinical setting. BPA and its metabolites were measured in serum and total BPA was measured in matching urine samples. The mean total exposure was similar to the 50(th) percentile of exposure for U.S. women and pregnant women in a large North American cohort. Twenty volunteers had total daily exposures equal to or exceeding the U.S. mean, and six volunteers had exposures exceeding the 75th percentile. Women working as cashiers did not have higher total BPA exposure. BPA was detected in some serum samples (0.25-0.51 ng/ml), but showed no relationship to total BPA in corresponding urine samples, no relationship to total BPA exposure, and had unconjugated BPA fractions of 60-80%, consistent with established criteria for sample contamination. We conclude that typical exposures of North American pregnant women produce internal exposures to BPA in the picomolar range. Copyright © 2016. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Teeguarden, Justin G AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Doerge, Daniel R AD - Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99352, United States; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 93771, United States. Electronic address: justin.teeguarden@pnl.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: nathan.twaddle@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: mona.churchwell@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: daniel.doerge@fda.hhs.gov. Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 129 EP - 142 VL - 92 KW - Index Medicus KW - Bisphenol A KW - Exposure KW - Endocrine disruptors KW - Biomonitoring KW - Pharmacokinetics KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1788226155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Urine+and+serum+biomonitoring+of+exposure+to+environmental+estrogens+I%3A+Bisphenol+A+in+pregnant+women.&rft.au=Teeguarden%2C+Justin+G%3BTwaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BDoerge%2C+Daniel+R&rft.aulast=Teeguarden&rft.aufirst=Justin&rft.date=2016-06-01&rft.volume=92&rft.issue=&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2016.03.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2016.03.023 ER - TY - JOUR T1 - The influence of daily sleep patterns of commercial truck drivers on driving performance AN - 1785243814; PQ0002919172 AB - Fatigued and drowsy driving has been found to be a major cause of truck crashes. Lack of sleep is the number one cause of fatigue and drowsiness. However, there are limited data on the sleep patterns (sleep duration, sleep percentage in the duration of non-work period, and the time when sleep occurred) of truck drivers in non-work periods and the impact on driving performance. This paper examined sleep patterns of 96 commercial truck drivers during non-work periods and evaluated the influence these sleep patterns had on truck driving performance. Data were from the Naturalistic Truck Driving Study. Each driver participated in the study for approximately four weeks. A shift was defined as a non-work period followed by a work period. A total of 1397 shifts were identified. Four distinct sleep patterns were identified based on sleep duration, sleep start/end point in a non-work period, and the percentage of sleep with reference to the duration of non-work period. Driving performance was measured by safety-critical events, which included crashes, near-crashes, crash-relevant conflicts, and unintentional lane deviations. Negative binomial regression was used to evaluate the association between the sleep patterns and driving performance, adjusted for driver demographic information. The results showed that the sleep pattern with the highest safety-critical event rate was associated with shorter sleep, sleep in the early stage of a non-work period, and less sleep between 1 a.m. and 5 a.m. This study also found that male drivers, with fewer years of commercial vehicle driving experience and higher body mass index, were associated with deteriorated driving performance and increased driving risk. The results of this study could inform hours-of-service policy-making and benefit safety management in the trucking industry. JF - Accident Analysis & Prevention AU - Chen, Guang Xiang AU - Fang, Youjia AU - Guo, Feng AU - Hanowski, Richard J AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, 1095 Willowdale Road, Morgantown, WV 26505, United States Y1 - 2016/06// PY - 2016 DA - June 2016 SP - 55 EP - 63 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 91 SN - 0001-4575, 0001-4575 KW - Health & Safety Science Abstracts KW - Naturalistic driving study KW - Sleep pattern KW - Cluster analysis KW - Negative binomial regression KW - Truck driver safety KW - Demography KW - Accidents KW - Prevention KW - Driving ability KW - Fatigue KW - Body mass KW - Safety KW - Occupational safety KW - Trucks KW - Traffic safety KW - Conflicts KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785243814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accident+Analysis+%26+Prevention&rft.atitle=The+influence+of+daily+sleep+patterns+of+commercial+truck+drivers+on+driving+performance&rft.au=Chen%2C+Guang+Xiang%3BFang%2C+Youjia%3BGuo%2C+Feng%3BHanowski%2C+Richard+J&rft.aulast=Chen&rft.aufirst=Guang&rft.date=2016-06-01&rft.volume=91&rft.issue=&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Accident+Analysis+%26+Prevention&rft.issn=00014575&rft_id=info:doi/10.1016%2Fj.aap.2016.02.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Demography; Prevention; Accidents; Fatigue; Driving ability; Body mass; Occupational safety; Safety; Trucks; Traffic safety; Conflicts DO - http://dx.doi.org/10.1016/j.aap.2016.02.027 ER - TY - JOUR T1 - Chrysophyllum cainito leaves are effective against pre-clinical chronic pain models: Analysis of crude extract, fraction and isolated compounds in mice AN - 1805505327; PQ0003023544 AB - Ethnopharmacological relevance Chrysophyllum cainito L. (Sapotaceae), commonly known as caimito or star apple, is a neotropical tree valued for its ornamental quality and edible fruits. Besides its culinary use, the leaves are also popularly used to treat diabetes mellitus and several inflammatory diseases. Aim of this study This study aimed to complement previous data obtained about the anti-hypersensitivity effects of the crude methanol extract (CME), CHCl sub(3) fraction and isolated compounds obtained from C. cainito. Materials and methods: The CME, CHCl sub(3) fraction and two isolated triterpenes identified as 3 beta -Lup-20(29)-en-3-yl acetate (1) and Lup-20(29)-en-3 beta -O-hexanoate (2) were evaluated regarding their effects using clinical pain models, such as post-operative, inflammatory and neuropathic pain. Acute inflammatory pain models induced by PGE sub(2), epinephrine, LPS and CFA were also used to improve the knowledge about the mechanism of action. Results: The animals treated with the CME and submitted to PGE sub(2), epinephrine, LPS or CFA had the mechanical hypersensitivity significantly reduced. When repeatedly administered, the CME enhanced the mechanical withdrawal threshold of mice submitted to post-operative pain model, CFA-induced chronic inflammatory pain and two different models of neuropathic pain. In turn, the CHCl sub(3) fraction presented anti-hypersensitivity effect against epinephrine- or LPS-induced hypersensitivity, with a more prominent activity in both the neuropathic pain models. The compound 1 seems to present the same profile of the CHCl sub(3), whereas compound 2 exhibited activity similar to the CME. Conclusions: This data suggests that the CME effect involves interference in the production, release or action of some chemical mediators, such as PGE sub(2), sympathetic amines, cytokines, etc. Part of these effects was observed with the CHCl3 fraction, emphasizing the prominent inhibition of neuropathic pain. The results also demonstrated that part of the CME effects are due to the presence of the triterpenes 1 and 2, but it is important to mention that we cannot discard the effects of countless other compounds presented in the crude extract, acting in a synergic way. JF - Journal of Ethnopharmacology AU - Meira, Nicole Anzanelo AU - Rocha, Lilian W AU - Silva, Gislaine Fda AU - Quintal, Zhelmy Martin AU - Monache, Franco Delle AU - Filho, Valdir Cechinel AU - Quintao, Nara Lins Meira Y1 - 2016/05/26/ PY - 2016 DA - 2016 May 26 SP - 30 EP - 41 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 184 SN - 0378-8741, 0378-8741 KW - Toxicology Abstracts KW - Chrysophyllum cainito L. KW - Triterpenes KW - Hypersensitivity KW - Chronic pain KW - Neuropathic pain KW - Inflammatory pain. KW - Fruits KW - Trees KW - Methanol KW - Chrysophyllum cainito KW - Leaves KW - Animal models KW - Pain KW - Prostaglandin E2 KW - Sapotaceae KW - Acetic acid KW - Inflammation KW - Diabetes mellitus KW - amines KW - Inflammatory diseases KW - Malus KW - Cytokines KW - Lipopolysaccharides KW - triterpenes KW - Epinephrine KW - Neuropathy KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805505327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Ethnopharmacology&rft.atitle=Chrysophyllum+cainito+leaves+are+effective+against+pre-clinical+chronic+pain+models%3A+Analysis+of+crude+extract%2C+fraction+and+isolated+compounds+in+mice&rft.au=Meira%2C+Nicole+Anzanelo%3BRocha%2C+Lilian+W%3BSilva%2C+Gislaine+Fda%3BQuintal%2C+Zhelmy+Martin%3BMonache%2C+Franco+Delle%3BFilho%2C+Valdir+Cechinel%3BQuintao%2C+Nara+Lins+Meira&rft.aulast=Meira&rft.aufirst=Nicole&rft.date=2016-05-26&rft.volume=184&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Journal+of+Ethnopharmacology&rft.issn=03788741&rft_id=info:doi/10.1016%2Fj.jep.2016.02.046 L2 - http://www.sciencedirect.com/science/article/pii/S0378874116300903 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Fruits; Trees; Methanol; Animal models; Leaves; Pain; Prostaglandin E2; Acetic acid; Inflammation; Diabetes mellitus; Hypersensitivity; amines; Inflammatory diseases; Lipopolysaccharides; Cytokines; triterpenes; Epinephrine; Neuropathy; Chrysophyllum cainito; Malus; Sapotaceae DO - http://dx.doi.org/10.1016/j.jep.2016.02.046 ER - TY - JOUR T1 - Genetic Variability of West Nile Virus in U.S. Blood Donors from the 2012 Epidemic Season AN - 1808632148; PQ0003280845 AB - West Nile virus (WNV) is an arbovirus maintained in nature in a bird-mosquito enzootic cycle which can also infect other vertebrates including humans. WNV is now endemic in the United States (U.S.), causing yearly outbreaks that have resulted in an estimated total of 4-5 million human infections. Over 41,700 cases of West Nile disease, including 18,810 neuroinvasive cases and 1,765 deaths, were reported to the CDC between 1999 and 2014. In 2012, the second largest West Nile outbreak in the U.S. was reported, which caused 5,674 cases and 286 deaths. WNV continues to evolve, and three major WNV lineage I genotypes (NY99, WN02, and SW/WN03) have been described in the U.S. since introduction of the virus in 1999. We report here the WNV sequences obtained from 19 human samples acquired during the 2012 U.S. outbreak and our examination of the evolutionary dynamics in WNV isolates sequenced from 1999-2012. Maximum-likelihood and Bayesian methods were used to perform the phylogenetic analyses. Selection pressure analyses were performed with the HyPhy package using the Datamonkey web-server. Using different codon-based and branch-site selection models, we detected a number of codons subjected to positive pressure in WNV genes. Thirteen of the 19 completely sequenced isolates from 10 U.S. states were genetically similar, sharing up to 55 nucleotide mutations and 4 amino acid substitutions when compared with the prototype isolate WN-NY99. Overall, these analyses showed that following a brief contraction in 2008-2009, WNV genetic divergence in the U.S. continued to increase in 2012, and that closely related variants were found across a broad geographic range of the U.S., coincident with the second-largest WNV outbreak in U.S. history. West Nile virus (WNV; family Flaviviridae, genus Flavivirus) is a mosquito-borne virus maintained in a bird-mosquito enzootic cycle. WNV can occasionally infect other animals and humans, which are considered dead-end hosts because they produce too little virus in blood to re-infect mosquitoes. Most human infections (~80%) do not cause symptoms, and when symptoms do occur, they may vary from mild flu-like illness to fatal neuroinvasive disease (~1%). WNV can be transmitted by transfusion of blood and blood components and by organ transplantation, posing a risk to the blood supply and public health. There is no specific therapy or vaccine for WNV in humans. WNV now is one of the most widely distributed flaviviruses in the world. Comparative studies of WNV genetic sequences have described two major groupings of WNV, lineages I and II, and up to five newer lineages, which correlate well with the geographical point of isolation. Since 1999, WNV has spread from New York City throughout the U.S. and the Americas including Mexico, Canada, the Caribbean and South America. The emergence of WNV in the U.S. with annual outbreaks represents a unique opportunity to understand how a mosquito-borne virus adapts and evolves in a new environment. Viral adaptation to domestic mosquitoes and birds is considered to have played an important role in the spread of WNV in the U.S. Continuous surveillance of WNV genetic variation is needed to protect public health because the tests used to diagnose infection and screen blood, as well as vaccines and drug therapies currently in development, may not perform as well against newer genetic variants of WNV. JF - PLoS Neglected Tropical Diseases AU - Grinev, Andriyan AU - Chancey, Caren AU - Volkova, Evgeniya AU - Anez, German AU - Heisey, Daniel AR AU - Winkelman, Valerie AU - Foster, Gregory A AU - Williamson, Phillip AU - Stramer, Susan L AU - Rios, Maria AD - Laboratory of Emerging Pathogens (LEP), Division of Emerging and Transfusion Transmitted Diseases (DETTD), Office of Blood Research and Review (OBRR), Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, Maryland, United States of America Y1 - 2016/05/16/ PY - 2016 DA - 2016 May 16 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 10 IS - 5 SN - 1935-2727, 1935-2727 KW - Virology & AIDS Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Health & Safety Science Abstracts KW - Amino acid substitution KW - Nucleotide sequence KW - Viruses KW - Disease control KW - Arbovirus KW - Flavivirus KW - Public health KW - ASW, Caribbean Sea KW - Phylogeny KW - Amino acids KW - Epidemics KW - Therapy KW - ANW, Canada KW - Drug development KW - Nucleotides KW - ASW, South America KW - Mexico KW - Codons KW - Vaccines KW - Mutation KW - Amino acid sequence KW - Symptoms KW - Invasiveness KW - Prototypes KW - Bayesian analysis KW - Genetic diversity KW - Genotypes KW - Infection KW - Comparative studies KW - Genetics KW - Drugs KW - Urban areas KW - Mortality KW - Blood donors KW - Mathematical models KW - Transplantation KW - Adaptations KW - ANW, USA, New York, New York City KW - Flaviviridae KW - Blood KW - USA KW - Outbreaks KW - West Nile virus KW - Evolution KW - Q1 08443:Population genetics KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - Q5 08524:Public health, medicines, dangerous organisms KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808632148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Genetic+Variability+of+West+Nile+Virus+in+U.S.+Blood+Donors+from+the+2012+Epidemic+Season&rft.au=Grinev%2C+Andriyan%3BChancey%2C+Caren%3BVolkova%2C+Evgeniya%3BAnez%2C+German%3BHeisey%2C+Daniel+AR%3BWinkelman%2C+Valerie%3BFoster%2C+Gregory+A%3BWilliamson%2C+Phillip%3BStramer%2C+Susan+L%3BRios%2C+Maria&rft.aulast=Grinev&rft.aufirst=Andriyan&rft.date=2016-05-16&rft.volume=10&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0004717 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Symptoms; Genetics; Blood; Nucleotide sequence; Therapy; Disease control; Vaccines; Amino acid sequence; Public health; Phylogeny; Blood donors; Invasiveness; Epidemics; Adaptations; Transplantation; Amino acid substitution; Mathematical models; Bayesian analysis; Genetic diversity; Drug development; Genotypes; Infection; Nucleotides; Codons; Mutation; Evolution; Mortality; Amino acids; Prototypes; Viruses; Comparative studies; Outbreaks; Drugs; Urban areas; West Nile virus; Flavivirus; Flaviviridae; Arbovirus; USA; ASW, South America; Mexico; ASW, Caribbean Sea; ANW, Canada; ANW, USA, New York, New York City DO - http://dx.doi.org/10.1371/journal.pntd.0004717 ER - TY - JOUR T1 - Computed Biological Relations among Five Select Treatment-Related Organ/Tissue Toxicities. AN - 1789496807; 27063352 AB - Drug toxicity presents a major challenge in drug development and patient care. We set to build upon previous works regarding select drug-induced toxicities to find common patterns in the mode of action of the drugs associated with these toxicities. In particular, we focused on five disparate organ toxicities, peripheral neuropathy (PN), rhabdomyolysis (RM), Stevens-Johnson syndrome/toxic epidermal necrosis (SJS/TEN), lung injury (LI), and heart contraction-related cardiotoxicity (CT), and identified biological commonalities between and among the toxicities in terms of pharmacological targets and nearest neighbors (indirect effects) using the hyper-geometric test and a distance metric of Spearman correlation. There were 20 significant protein targets associated with two toxicities and 0 protein targets associated with three or more toxicities. Per Spearman distance, PN was closest to SJS/TEN compared to other pairs, whereas the pairs involving RM were more different than others excluding RM. The significant targets associated with RM outnumbered those associated with every one of the other four toxicities. Enrichment analysis of drug targets that are expressed in corresponding organ/tissues determined proteins that should be avoided in drug discovery. The identified biological patterns emerging from the mode of action of these drugs are statistically associated with these serious toxicities and could potentially be used as predictors for new drug candidates. The predictive power and usefulness of these biological patterns will increase with the database of these five toxicities. Furthermore, extension of our approach to all severe adverse reactions will produce useful biological commonalities for reference in drug discovery and development. JF - Chemical research in toxicology AU - Sakellaropoulos, Theodore AU - Herod, Timothy J AU - Alexopoulos, Leonidas G AU - Bai, Jane P F AD - Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration , Silver Spring, Maryland 20993, United States. ; School of Mechanical Engineering, National Technical University of Athens , Athens, Greece. Y1 - 2016/05/16/ PY - 2016 DA - 2016 May 16 SP - 914 EP - 923 VL - 29 IS - 5 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789496807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Computed+Biological+Relations+among+Five+Select+Treatment-Related+Organ%2FTissue+Toxicities.&rft.au=Sakellaropoulos%2C+Theodore%3BHerod%2C+Timothy+J%3BAlexopoulos%2C+Leonidas+G%3BBai%2C+Jane+P+F&rft.aulast=Sakellaropoulos&rft.aufirst=Theodore&rft.date=2016-05-16&rft.volume=29&rft.issue=5&rft.spage=914&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.6b00060 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.6b00060 ER - TY - JOUR T1 - Enzymatic oxidative biodegradation of nanoparticles: Mechanisms, significance and applications. AN - 1777076133; 26768553 AB - Biopersistence of carbon nanotubes, graphene oxide (GO) and several other types of carbonaceous nanomaterials is an essential determinant of their health effects. Successful biodegradation is one of the major factors defining the life span and biological responses to nanoparticles. Here, we review the role and contribution of different oxidative enzymes of inflammatory cells - myeloperoxidase, eosinophil peroxidase, lactoperoxidase, hemoglobin, and xanthine oxidase - to the reactions of nanoparticle biodegradation. We further focus on interactions of nanomaterials with hemoproteins dependent on the specific features of their physico-chemical and structural characteristics. Mechanistically, we highlight the significance of immobilized peroxidase reactive intermediates vs diffusible small molecule oxidants (hypochlorous and hypobromous acids) for the overall oxidative biodegradation process in neutrophils and eosinophils. We also accentuate the importance of peroxynitrite-driven pathways realized in macrophages via the engagement of NADPH oxidase- and NO synthase-triggered oxidative mechanisms. We consider possible involvement of oxidative machinery of other professional phagocytes such as microglial cells, myeloid-derived suppressor cells, in the context of biodegradation relevant to targeted drug delivery. We evaluate the importance of genetic factors and their manipulations for the enzymatic biodegradation in vivo. Finally, we emphasize a novel type of biodegradation realized via the activation of the "dormant" peroxidase activity of hemoproteins by the nano-surface. This is exemplified by the binding of GO to cyt c causing the unfolding and 'unmasking' of the peroxidase activity of the latter. We conclude with the strategies leading to safe by design carbonaceous nanoparticles with optimized characteristics for mechanism-based targeted delivery and regulatable life-span of drugs in circulation. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Vlasova, Irina I AU - Kapralov, Alexandr A AU - Michael, Zachary P AU - Burkert, Seth C AU - Shurin, Michael R AU - Star, Alexander AU - Shvedova, Anna A AU - Kagan, Valerian E AD - Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, United States; Research Institute for Physico-Chemical Medicine, Federal Medico-Biological Agency, Moscow 119453, Russia. ; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, United States. ; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, United States. ; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, United States; Department of Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, United States. ; Pathology and Physiology Research Branch, Health Effects Laboratory Division (HELD), National Institute for Occupational Safety and Health (NIOSH) and Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26505, United States. Electronic address: ats@cdc.gov. ; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, United States; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, United States; Departments of Pharmacology and Chemical Biology and Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15260, United States. Electronic address: kagan@pitt.edu. Y1 - 2016/05/15/ PY - 2016 DA - 2016 May 15 SP - 58 EP - 69 VL - 299 KW - Nanotubes, Carbon KW - 0 KW - Peroxidases KW - EC 1.11.1.- KW - Index Medicus KW - Carbon nanotubes KW - Graphene oxide KW - Phagocytes KW - Free radicals KW - Peroxidase activity KW - Oxidants KW - Oxidation-Reduction KW - Neutrophils -- metabolism KW - Animals KW - Nanotubes, Carbon -- chemistry KW - Humans KW - Oxidative Stress -- physiology KW - Nanoparticles -- metabolism KW - Peroxidases -- chemistry KW - Peroxidases -- metabolism KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777076133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Enzymatic+oxidative+biodegradation+of+nanoparticles%3A+Mechanisms%2C+significance+and+applications.&rft.au=Vlasova%2C+Irina+I%3BKapralov%2C+Alexandr+A%3BMichael%2C+Zachary+P%3BBurkert%2C+Seth+C%3BShurin%2C+Michael+R%3BStar%2C+Alexander%3BShvedova%2C+Anna+A%3BKagan%2C+Valerian+E&rft.aulast=Vlasova&rft.aufirst=Irina&rft.date=2016-05-15&rft.volume=299&rft.issue=&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-18 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Biol Chem. 2006 May 26;281(21):14554-62 [16543234] Toxicol Lett. 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[23333322] ACS Nano. 2013 Mar 26;7(3):1974-89 [23413928] Adv Mater. 2013 May 14;25(18):2594-9 [23418013] J Biol Chem. 2013 Jun 14;288(24):17074-81 [23632017] Nanomedicine. 2013 Jul;9(5):583-93 [23117048] ACS Appl Mater Interfaces. 2014 Jul 9;6(13):10373-80 [24933259] Environ Sci Technol. 2014 Jul 15;48(14):7918-23 [24988479] Biosens Bioelectron. 2011 May 15;26(9):3914-9 [21497079] Nanoscale. 2014 Dec 21;6(24):14686-90 [25377797] J Am Chem Soc. 2015 Jan 21;137(2):675-84 [25530234] Biochem J. 2015 Jan 1;465(1):127-37 [25327890] Nanoscale. 2015 Feb 21;7(7):2834-40 [25597450] Nanoscale. 2015 May 21;7(19):8689-94 [25902750] Adv Exp Med Biol. 2015;851:1-61 [26002730] Eur J Pharm Biopharm. 2015 Jun;93:52-79 [25813885] J Biol Chem. 2001 Jul 6;276(27):25318-23 [11320098] Biochem Biophys Res Commun. 2003 Feb 7;301(2):551-7 [12565898] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.01.002 ER - TY - GEN T1 - Nanotoxicology ten years later: Lights and shadows. AN - 1777076018; 26908175 AB - The mounting societal concerns about possible and maybe even likely adverse effects of nanomaterials are reflected in a large and growing number of publications in the field of nanotoxicology. Indeed, today's search in PubMed reveals >3700 publications on the subject denoted by (toxic+nanomaterials) - quite a growth over the last decade that began with only two dozens of them up-to 2005. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Shvedova, Anna AU - Pietroiusti, Antonio AU - Kagan, Valerian Y1 - 2016/05/15/ PY - 2016 DA - 2016 May 15 SP - 1 EP - 2 VL - 299 KW - Index Medicus KW - Nanomaterials KW - Global representation KW - Nanotoxicology KW - Nanotechnology KW - Animals KW - Particle Size KW - Humans KW - Light KW - Nanotechnology -- trends KW - Nanostructures -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777076018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Nanotoxicology+ten+years+later%3A+Lights+and+shadows.&rft.au=Shvedova%2C+Anna%3BPietroiusti%2C+Antonio%3BKagan%2C+Valerian&rft.aulast=Shvedova&rft.aufirst=Anna&rft.date=2016-05-15&rft.volume=299&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.02.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-18 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.02.014 ER - TY - JOUR T1 - Biomarkers of susceptibility: State of the art and implications for occupational exposure to engineered nanomaterials. AN - 1777075737; 26724381 AB - Rapid advances and applications in nanotechnology are expected to result in increasing occupational exposure to nano-sized materials whose health impacts are still not completely understood. Scientific efforts are required to identify hazards from nanomaterials and define risks and precautionary management strategies for exposed workers. In this scenario, the definition of susceptible populations, which may be at increased risk of adverse effects may be important for risk assessment and management. The aim of this review is to critically examine available literature to provide a comprehensive overview on susceptibility aspects potentially affecting heterogeneous responses to nanomaterials workplace exposure. Genetic, genotoxic and epigenetic alterations induced by nanomaterials in experimental studies were assessed with respect to their possible function as determinants of susceptibility. Additionally, the role of host factors, i.e. age, gender, and pathological conditions, potentially affecting nanomaterial toxicokinetic and health impacts, were also analysed. Overall, this review provides useful information to obtain insights into the nanomaterial mode of action in order to identify potentially sensitive, specific susceptibility biomarkers to be validated in occupational settings and addressed in risk assessment processes. The findings of this review are also important to guide future research into a deeper characterization of nanomaterial susceptibility in order to define adequate risk communication strategies. Ultimately, identification and use of susceptibility factors in workplace settings has both scientific and ethical issues that need addressing. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Iavicoli, Ivo AU - Leso, Veruscka AU - Schulte, Paul A AD - Department of Public Health, Division of Occupational Medicine, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy. Electronic address: ivo.iavicoli@unina.it. ; Institute of Public Health, Section of Occupational Medicine, Catholic University of the Sacred Heart, Largo Francesco Vito 1, 00168 Rome, Italy. Electronic address: veruscka@email.it. ; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, MS C-14, Cincinnati, OH 45226, USA. Electronic address: pas4@cdc.gov. Y1 - 2016/05/15/ PY - 2016 DA - 2016 May 15 SP - 112 EP - 124 VL - 299 KW - Biomarkers KW - 0 KW - Index Medicus KW - Nanomaterial risk assessment KW - Epigenetic alterations KW - Occupational biomonitoring KW - Toxicogenomic information KW - Nanomaterial susceptibility factors KW - Genetic variances KW - Animals KW - Metabolic Networks and Pathways -- physiology KW - Genetic Variation -- drug effects KW - Humans KW - Genetic Variation -- physiology KW - Biomarkers -- metabolism KW - Metabolic Networks and Pathways -- drug effects KW - Inhalation Exposure -- adverse effects KW - Occupational Exposure -- prevention & control KW - Nanostructures -- adverse effects KW - Disease Susceptibility -- epidemiology KW - Occupational Exposure -- adverse effects KW - Disease Susceptibility -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777075737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Biomarkers+of+susceptibility%3A+State+of+the+art+and+implications+for+occupational+exposure+to+engineered+nanomaterials.&rft.au=Iavicoli%2C+Ivo%3BLeso%2C+Veruscka%3BSchulte%2C+Paul+A&rft.aulast=Iavicoli&rft.aufirst=Ivo&rft.date=2016-05-15&rft.volume=299&rft.issue=&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.12.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-18 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.12.018 ER - TY - JOUR T1 - Fibrosis biomarkers in workers exposed to MWCNTs. AN - 1777075516; 26902652 AB - Multi-walled carbon nanotubes (MWCNT) with their unique physico-chemical properties offer numerous technological advantages and are projected to drive the next generation of manufacturing growth. As MWCNT have already found utility in different industries including construction, engineering, energy production, space exploration and biomedicine, large quantities of MWCNT may reach the environment and inadvertently lead to human exposure. This necessitates the urgent assessment of their potential health effects in humans. The current study was carried out at NanotechCenter Ltd. Enterprise (Tambov, Russia) where large-scale manufacturing of MWCNT along with relatively high occupational exposure levels was reported. The goal of this small cross-sectional study was to evaluate potential biomarkers during occupational exposure to MWCNT. All air samples were collected at the workplaces from both specific areas and personal breathing zones using filter-based devices to quantitate elemental carbon and perform particle analysis by TEM. Biological fluids of nasal lavage, induced sputum and blood serum were obtained from MWCNT-exposed and non-exposed workers for assessment of inflammatory and fibrotic markers. It was found that exposure to MWCNTs caused significant increase in IL-1β, IL6, TNF-α, inflammatory cytokines and KL-6, a serological biomarker for interstitial lung disease in collected sputum samples. Moreover, the level of TGF-β1 was increased in serum obtained from young exposed workers. Overall, the results from this study revealed accumulation of inflammatory and fibrotic biomarkers in biofluids of workers manufacturing MWCNTs. Therefore, the biomarkers analyzed should be considered for the assessment of health effects of occupational exposure to MWCNT in cross-sectional epidemiological studies. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Fatkhutdinova, Liliya M AU - Khaliullin, Timur O AU - Vasil'yeva, Olga L AU - Zalyalov, Ramil R AU - Mustafin, Ilshat G AU - Kisin, Elena R AU - Birch, M Eileen AU - Yanamala, Naveena AU - Shvedova, Anna A AD - Kazan State Medical University, ul. Butlerova 49, Kazan 420012, Russia. Electronic address: liliya.fatkhutdinova@gmail.com. ; Kazan State Medical University, ul. Butlerova 49, Kazan 420012, Russia; Department of Physiology & Pharmacology, WVU, Morgantown, WV, USA. Electronic address: Khaliullin.40k@gmail.com. ; Kazan State Medical University, ul. Butlerova 49, Kazan 420012, Russia. Electronic address: volgaleon@gmail.com. ; Kazan State Medical University, ul. Butlerova 49, Kazan 420012, Russia. Electronic address: zalyalov.ramil@gmail.com. ; Kazan State Medical University, ul. Butlerova 49, Kazan 420012, Russia. Electronic address: ilshat64@mail.ru. ; National Institute for Occupational Safety and Health, Morgantown, WV, USA. Electronic address: edk8@cdc.gov. ; National Institute for Occupational Safety and Health, Cincinnati, OH, USA. Electronic address: mib2@cdc.gov. ; National Institute for Occupational Safety and Health, Morgantown, WV, USA. Electronic address: wqu1@cdc.gov. ; National Institute for Occupational Safety and Health, Morgantown, WV, USA; Department of Physiology & Pharmacology, WVU, Morgantown, WV, USA. Electronic address: ats1@cdc.gov. Y1 - 2016/05/15/ PY - 2016 DA - 2016 May 15 SP - 125 EP - 131 VL - 299 KW - Biomarkers KW - 0 KW - Cytokines KW - Nanotubes, Carbon KW - Index Medicus KW - Workers KW - TGF-beta KW - KL-6 KW - Fibrosis KW - Osteopontin KW - MWCNT KW - Cytokines -- blood KW - Young Adult KW - Humans KW - Adult KW - Sputum -- drug effects KW - Biomarkers -- metabolism KW - Middle Aged KW - Cytokines -- metabolism KW - Sputum -- metabolism KW - Biomarkers -- blood KW - Male KW - Female KW - Pulmonary Fibrosis -- diagnosis KW - Pulmonary Fibrosis -- chemically induced KW - Occupational Exposure -- adverse effects KW - Nanotubes, Carbon -- toxicity KW - Pulmonary Fibrosis -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777075516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Fibrosis+biomarkers+in+workers+exposed+to+MWCNTs.&rft.au=Fatkhutdinova%2C+Liliya+M%3BKhaliullin%2C+Timur+O%3BVasil%27yeva%2C+Olga+L%3BZalyalov%2C+Ramil+R%3BMustafin%2C+Ilshat+G%3BKisin%2C+Elena+R%3BBirch%2C+M+Eileen%3BYanamala%2C+Naveena%3BShvedova%2C+Anna+A&rft.aulast=Fatkhutdinova&rft.aufirst=Liliya&rft.date=2016-05-15&rft.volume=299&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.02.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-18 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.02.016 ER - TY - JOUR T1 - A novel procedure on next generation sequencing data analysis using text mining algorithm. AN - 1789495405; 27177941 AB - Next-generation sequencing (NGS) technologies have provided researchers with vast possibilities in various biological and biomedical research areas. Efficient data mining strategies are in high demand for large scale comparative and evolutional studies to be performed on the large amounts of data derived from NGS projects. Topic modeling is an active research field in machine learning and has been mainly used as an analytical tool to structure large textual corpora for data mining. We report a novel procedure to analyse NGS data using topic modeling. It consists of four major procedures: NGS data retrieval, preprocessing, topic modeling, and data mining using Latent Dirichlet Allocation (LDA) topic outputs. The NGS data set of the Salmonella enterica strains were used as a case study to show the workflow of this procedure. The perplexity measurement of the topic numbers and the convergence efficiencies of Gibbs sampling were calculated and discussed for achieving the best result from the proposed procedure. The output topics by LDA algorithms could be treated as features of Salmonella strains to accurately describe the genetic diversity of fliC gene in various serotypes. The results of a two-way hierarchical clustering and data matrix analysis on LDA-derived matrices successfully classified Salmonella serotypes based on the NGS data. The implementation of topic modeling in NGS data analysis procedure provides a new way to elucidate genetic information from NGS data, and identify the gene-phenotype relationships and biomarkers, especially in the era of biological and medical big data. The implementation of topic modeling in NGS data analysis provides a new way to elucidate genetic information from NGS data, and identify the gene-phenotype relationships and biomarkers, especially in the era of biological and medical big data. JF - BMC bioinformatics AU - Zhao, Weizhong AU - Chen, James J AU - Perkins, Roger AU - Wang, Yuping AU - Liu, Zhichao AU - Hong, Huixiao AU - Tong, Weida AU - Zou, Wen AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA. wen.zou@fda.hhs.gov. Y1 - 2016/05/13/ PY - 2016 DA - 2016 May 13 SP - 213 VL - 17 IS - 1 KW - Index Medicus KW - Data mining KW - Next-generation sequencing (NGS) KW - Genetic diversity KW - Topic modeling KW - Biomarker UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789495405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+bioinformatics&rft.atitle=A+novel+procedure+on+next+generation+sequencing+data+analysis+using+text+mining+algorithm.&rft.au=Zhao%2C+Weizhong%3BChen%2C+James+J%3BPerkins%2C+Roger%3BWang%2C+Yuping%3BLiu%2C+Zhichao%3BHong%2C+Huixiao%3BTong%2C+Weida%3BZou%2C+Wen&rft.aulast=Zhao&rft.aufirst=Weizhong&rft.date=2016-05-13&rft.volume=17&rft.issue=1&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=BMC+bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2Fs12859-016-1075-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Microbiol. 2010 Sep;48(9):3122-6 [20631109] J Bacteriol. 1999 Dec;181(23):7149-53 [10572114] J Comput Biol. 2000 Feb-Apr;7(1-2):203-14 [10890397] J Clin Microbiol. 2001 Oct;39(10):3609-16 [11574581] Nucleic Acids Res. 2004;32(5):1792-7 [15034147] Proc Natl Acad Sci U S A. 2004 Apr 6;101 Suppl 1:5228-35 [14872004] Gene. 1988 Dec 15;73(1):237-44 [3243435] J Clin Microbiol. 2007 Feb;45(2):472-6 [17166969] Clin Chem. 2009 May;55(5):856-66 [19264858] Nat Rev Genet. 2010 Jan;11(1):31-46 [19997069] N Engl J Med. 2011 Mar 10;364(10):981-2 [21345093] J Genet Genomics. 2011 Mar 20;38(3):95-109 [21477781] Bioinformatics. 2011 Jul 1;27(13):i61-8 [21685102] J Clin Microbiol. 2012 May;50(5):1524-32 [22378901] BMC Genomics. 2012;13:32 [22260654] N Engl J Med. 2012 Jun 14;366(24):2267-75 [22693998] PLoS Pathog. 2012;8(6):e1002776 [22737074] J Gen Virol. 2012 Sep;93(Pt 9):1853-68 [22647373] Nat Rev Genet. 2012 Sep;13(9):601-12 [22868263] BMC Bioinformatics. 2012;13 Suppl 15:S6 [23046522] FEMS Microbiol Lett. 2012 Dec;337(1):61-72 [22998607] PLoS One. 2013;8(1):e55254 [23383127] J Clin Microbiol. 2013 Jun;51(6):1786-97 [23554194] Cell. 2013 Sep 26;155(1):27-38 [24074859] Genome Res. 2014 Jul;24(7):1180-92 [24899342] BMC Bioinformatics. 2014;15 Suppl 11:S11 [25350106] BMC Bioinformatics. 2015;16 Suppl 5:S2 [25859745] Biomark Med. 2015;9(11):1253-64 [26501894] Erratum In: BMC Bioinformatics. 2016;17:301 [27489012] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12859-016-1075-9 ER - TY - JOUR T1 - Prussian Blue Nanoparticles as Multienzyme Mimetics and Reactive Oxygen Species Scavengers. AN - 1789034906; 26918394 AB - The generation of reactive oxygen species (ROS) is an important mechanism of nanomaterial toxicity. We found that Prussian blue nanoparticles (PBNPs) can effectively scavenge ROS via multienzyme-like activity including peroxidase (POD), catalase (CAT), and superoxide dismutase (SOD) activity. Instead of producing hydroxyl radicals (•OH) through the Fenton reaction, PBNPs were shown to be POD mimetics that can inhibit •OH generation. We theorized for the first time that the multienzyme-like activities of PBNPs were likely caused by the abundant redox potentials of their different forms, making them efficient electron transporters. To study the ROS scavenging ability of PBNPs, a series of in vitro ROS-generating models was established using chemicals, UV irradiation, oxidized low-density lipoprotein, high glucose contents, and oxygen glucose deprivation and reperfusion. To demonstrate the ROS scavenging ability of PBNPs, an in vivo inflammation model was established using lipoproteins in Institute for Cancer Research (ICR) mice. The results indicated that PBNPs hold great potential for inhibiting or relieving injury induced by ROS in these pathological processes. JF - Journal of the American Chemical Society AU - Zhang, Wei AU - Hu, Sunling AU - Yin, Jun-Jie AU - He, Weiwei AU - Lu, Wei AU - Ma, Ming AU - Gu, Ning AU - Zhang, Yu AD - State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University , Nanjing 210096, P. R. China. ; Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration , College Park, Maryland 20740, United States. ; Department of Neurobiology, Nanjing Medical University & Key Laboratory of Developmental Genes and Human Disease, Institute of Life Sciences, Southeast University , Nanjing 210096, P. R. China. Y1 - 2016/05/11/ PY - 2016 DA - 2016 May 11 SP - 5860 EP - 5865 VL - 138 IS - 18 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1789034906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Prussian+Blue+Nanoparticles+as+Multienzyme+Mimetics+and+Reactive+Oxygen+Species+Scavengers.&rft.au=Zhang%2C+Wei%3BHu%2C+Sunling%3BYin%2C+Jun-Jie%3BHe%2C+Weiwei%3BLu%2C+Wei%3BMa%2C+Ming%3BGu%2C+Ning%3BZhang%2C+Yu&rft.aulast=Zhang&rft.aufirst=Wei&rft.date=2016-05-11&rft.volume=138&rft.issue=18&rft.spage=5860&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=1520-5126&rft_id=info:doi/10.1021%2Fjacs.5b12070 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/jacs.5b12070 ER - TY - JOUR T1 - Modeling carbon monoxide spread in underground mine fires. AN - 1826676754; 27069400 AB - Carbon monoxide (CO) poisoning is a leading cause of mine fire fatalities in underground mines. To reduce the hazard of CO poisoning in underground mines, it is important to accurately predict the spread of CO in underground mine entries when a fire occurs. This paper presents a study on modeling CO spread in underground mine fires using both the Fire Dynamics Simulator (FDS) and the MFIRE programs. The FDS model simulating part of the mine ventilation network was calibrated using CO concentration data from full-scale mine fire tests. The model was then used to investigate the effect of airflow leakage on CO concentration reduction in the mine entries. The inflow of fresh air at the leakage location was found to cause significant CO reduction. MFIRE simulation was conducted to predict the CO spread in the entire mine ventilation network using both a constant heat release rate and a dynamic fire source created from FDS. The results from both FDS and MFIRE simulations are compared and the implications of the improved MFIRE capability are discussed. JF - Applied thermal engineering AU - Yuan, Liming AU - Zhou, Lihong AU - Smith, Alex C AD - Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, 626 Cochrans Mill Road, Pittsburgh, PA 15236, USA. Y1 - 2016/05/05/ PY - 2016 DA - 2016 May 05 SP - 1319 EP - 1326 VL - 100 SN - 1359-4311, 1359-4311 KW - Carbon monoxide KW - Mine fires KW - Computational fluid dynamics KW - Ventilation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826676754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+thermal+engineering&rft.atitle=Modeling+carbon+monoxide+spread+in+underground+mine+fires.&rft.au=Yuan%2C+Liming%3BZhou%2C+Lihong%3BSmith%2C+Alex+C&rft.aulast=Yuan&rft.aufirst=Liming&rft.date=2016-05-05&rft.volume=100&rft.issue=&rft.spage=1319&rft.isbn=&rft.btitle=&rft.title=Applied+thermal+engineering&rft.issn=13594311&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-04-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Direct stimulation of human fibroblasts by nCeO2 in vitro is attenuated with an amorphous silica coating. AN - 1787096371; 27142434 AB - Nano-scaled cerium oxide (nCeO2) is used in a variety of applications, including use as a fuel additive, catalyst, and polishing agent, yet potential adverse health effects associated with nCeO2 exposure remain incompletely understood. Given the increasing utility and demand for engineered nanomaterials (ENMs) such as nCeO2, "safety-by-design" approaches are currently being sought, meaning that the physicochemical properties (e.g., size and surface chemistry) of the ENMs are altered in an effort to maximize functionality while minimizing potential toxicity. In vivo studies have shown in a rat model that inhaled nCeO2 deposited deep in the lung and induced fibrosis. However, little is known about how the physicochemical properties of nCeO2, or the coating of the particles with a material such as amorphous silica (aSiO2), may affect the bio-activity of these particles. Thus, we hypothesized that the physicochemical properties of nCeO2 may explain its potential to induce fibrogenesis, and that a nano-thin aSiO2 coating on nCeO2 may counteract that effect. Primary normal human lung fibroblasts were treated at occupationally relevant doses with nCeO2 that was either left uncoated or was coated with aSiO2 (amsCeO2). Subsequently, fibroblasts were analyzed for known hallmarks of fibrogenesis, including cell proliferation and collagen production, as well as the formation of fibroblastic nodules. The results of this study are consistent with this hypothesis, as we found that nCeO2 directly induced significant production of collagen I and increased cell proliferation in vitro, while amsCeO2 did not. Furthermore, treatment of fibroblasts with nCeO2, but not amsCeO2, significantly induced the formation of fibroblastic nodules, a clear indicator of fibrogenicity. Such in vitro data is consistent with recent in vivo observations using the same nCeO2 nanoparticles and relevant doses. This effect appeared to be mediated through TGFβ signaling since chemical inhibition of the TGFβ receptor abolished these responses. These results indicate that differences in the physicochemical properties of nCeO2 may alter the fibrogenicity of this material, thus highlighting the potential benefits of "safety-by-design" strategies. In addition, this study provides an efficient in vitro method for testing the fibrogenicity of ENMs that strongly correlates with in vivo findings. JF - Particle and fibre toxicology AU - Davidson, Donna C AU - Derk, Raymond AU - He, Xiaoqing AU - Stueckle, Todd A AU - Cohen, Joel AU - Pirela, Sandra V AU - Demokritou, Philip AU - Rojanasakul, Yon AU - Wang, Liying AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, WV, 26505, USA. ; Department of Pharmaceutical Sciences and Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, USA. ; Department of Environmental Health, Center for Nanotechnology and Nanotoxicology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. ; National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, WV, 26505, USA. LRojanasakul@cdc.gov. Y1 - 2016/05/04/ PY - 2016 DA - 2016 May 04 SP - 23 VL - 13 IS - 1 KW - Index Medicus KW - Engineered nanomaterials KW - in vitro dosimetry KW - Fibrosis KW - Nanotoxicology KW - Cerium oxide nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787096371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Direct+stimulation+of+human+fibroblasts+by+nCeO2+in+vitro+is+attenuated+with+an+amorphous+silica+coating.&rft.au=Davidson%2C+Donna+C%3BDerk%2C+Raymond%3BHe%2C+Xiaoqing%3BStueckle%2C+Todd+A%3BCohen%2C+Joel%3BPirela%2C+Sandra+V%3BDemokritou%2C+Philip%3BRojanasakul%2C+Yon%3BWang%2C+Liying&rft.aulast=Davidson&rft.aufirst=Donna&rft.date=2016-05-04&rft.volume=13&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2Fs12989-016-0134-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-04 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Trace Elem Med Biol. 2001 Apr;14(4):232-6 [11396783] Exp Neurol. 2015 Nov;273:151-60 [26277686] Occup Environ Med. 1994 Mar;51(3):195-9 [8130849] Mod Pathol. 1995 Oct;8(8):859-65 [8552576] Scand J Work Environ Health. 1995;21 Suppl 2:19-21 [8929682] Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14265-70 [18809927] ACS Nano. 2008 Oct 28;2(10):2121-34 [19206459] Am J Respir Cell Mol Biol. 2010 Feb;42(2):140-8 [19372246] J Toxicol Environ Health A. 2010;73(5):410-22 [20155582] J Exp Med. 2010 Aug 2;207(8):1589-97 [20643828] Part Fibre Toxicol. 2010;7:31 [20958985] Crit Rev Toxicol. 2011 Mar;41(3):213-29 [21244219] ACS Nano. 2011 Mar 22;5(3):1805-17 [21323332] Toxicol Lett. 2011 Aug 28;205(2):105-15 [21624445] Nanotoxicology. 2011 Sep;5(3):312-25 [20925443] Int J Clin Exp Pathol. 2012;5(1):58-71 [22295148] Chem Soc Rev. 2012 Apr 7;41(7):2780-99 [22086677] ACS Nano. 2012 May 22;6(5):4349-68 [22502734] Nat Med. 2012 Jul;18(7):1028-40 [22772564] Toxicol Appl Pharmacol. 2012 Aug 1;262(3):255-64 [22613087] Respir Res. 2012;13:62 [22838404] Nanotoxicology. 2013 Jun;7(4):417-31 [22393878] Nanotoxicology. 2013 Dec;7(8):1338-50 [23061914] Cardiovasc Toxicol. 2013 Dec;13(4):323-37 [23645470] Nanotoxicology. 2014 Nov;8(7):786-98 [23914771] Nanotoxicology. 2014 Sep;8(6):643-53 [23768316] PLoS One. 2014;9(1):e85835 [24465736] Nat Commun. 2014;5:3514 [24675174] Part Fibre Toxicol. 2014;11:20 [24885440] Toxicol Appl Pharmacol. 2014 Jul 15;278(2):135-47 [24793434] Nano Lett. 2014 Jun 11;14(6):3110-6 [24873662] BMC Genomics. 2014;15:700 [25145350] Biol Trace Elem Res. 2015 Jul;166(1):96-107 [25778836] Biomed Pharmacother. 2015 Jul;73:80-6 [26211586] Toxicol Appl Pharmacol. 2015 Oct 1;288(1):63-73 [26210349] Nanotoxicology. 2015;9(7):871-85 [25672815] Part Fibre Toxicol. 2015;12:31 [26458946] Am J Physiol Lung Cell Mol Physiol. 2015 Oct 15;309(8):L821-33 [26472812] Crit Care Med. 2015 Nov;43(11):e477-89 [26327202] Sci Total Environ. 1982 Dec;26(1):19-32 [7167813] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12989-016-0134-8 ER - TY - JOUR T1 - Exposure estimate for FD&C colour additives for the US population AN - 1808740061; PQ0003207083 AB - Dietary exposures to the seven food, drug, and cosmetic (FD&C) colour additives that are approved for general use in food in the United States were estimated for the US population (aged 2 years and older), children (aged 2-5 years) and teenage boys (aged 13-18 years) based on analytical levels of the FD&C colour additives in foods. Approximately 600 foods were chosen for analysis, based on a survey of product labels, for the levels of FD&C colour additives. Dietary exposure was estimated using both 2-day food consumption data from the combined 2007-10 National Health and Nutrition Examination Survey (NHANES) and 10-14-day food consumption data from the 2007-10 NPD Group, Inc. National Eating Trends - Nutrient Intake Database (NPD NET-NID). Dietary exposure was estimated at the mean and 90th percentile using three different exposure scenarios: low exposure, average exposure and high exposure, to account for the range in the amount of each FD&C colour additive for a given food. For all populations and all exposure scenarios, the highest cumulative eaters-only exposures in food were determined for FD&C Red No. 40, FD&C Yellow No. 5 and FD&C Yellow No. 6. In addition, the eaters-only exposure was estimated for individual food categories in order to determine which food categories contributed the most to the exposure for each FD&C colour additive. Breakfast Cereal, Juice Drinks, Soft Drinks, and Frozen Dairy Desserts/Sherbet (also referred to as Ice Cream, Frozen Yogurt, Sherbet (including Bars, Sticks, Sandwiches)) were the major contributing food categories to exposure for multiple FD&C colour additives for all three populations. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Doell, Diana L AU - Folmer, Daniel E AU - Lee, Hyoung S AU - Butts, Kyla M AU - Carberry, Susan E AD - Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, US Food and Drug Administration (USFDA), College Park, MD, USA Y1 - 2016/05/03/ PY - 2016 DA - 2016 May 03 SP - 782 EP - 797 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 5 SN - 1944-0049, 1944-0049 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Juices KW - Dairy products KW - Nutrients KW - Cosmetics KW - Nutrition KW - Food consumption KW - Food additives KW - Cereals KW - Drugs KW - Adolescents KW - Diets KW - Data processing KW - Beverages KW - Children KW - Food contamination KW - Yogurt KW - Databases KW - USA KW - Dairies KW - Ice cream KW - Additives KW - X 24340:Cosmetics, Toiletries & Household Products KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808740061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Exposure+estimate+for+FD%26amp%3BC+colour+additives+for+the+US+population&rft.au=Doell%2C+Diana+L%3BFolmer%2C+Daniel+E%3BLee%2C+Hyoung+S%3BButts%2C+Kyla+M%3BCarberry%2C+Susan+E&rft.aulast=Doell&rft.aufirst=Diana&rft.date=2016-05-03&rft.volume=33&rft.issue=5&rft.spage=782&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1179536 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Beverages; Data processing; Dairy products; Juices; Cosmetics; Nutrients; Food contamination; Children; Nutrition; Yogurt; Databases; Food consumption; Food additives; Dairies; Ice cream; Cereals; Drugs; Diets; Additives; Adolescents; USA DO - http://dx.doi.org/10.1080/19440049.2016.1179536 ER - TY - JOUR T1 - Influence of aqueous food simulants on potential nanoparticle detection in migration studies involving nanoenabled food-contact substances AN - 1808623735; PQ0003207078 AB - Research focused on assessing potential consumer exposure to nanoparticles released from nano-enabled food-contact materials (FCMs) has often reached conflicting conclusions regarding the detection of migrating nanoparticles. These conflicting conclusions, coupled with the potential for nanoparticles to be unstable in certain food simulants, has necessitated a closer look at the role played by food simulants recommended for use in nanoparticle migration evaluation. The influence of aqueous food simulants on nanoparticles under migration evaluation conditions is reported herein. The stability of silver nanoparticles (AgNP) spiked into three food simulants (water, 10% ethanol and 3% acetic acid) was investigated using asymmetric flow field-flow fractionation (AF4), ultrafiltration, electron microscopy (EM), and single-particle inductively coupled plasma mass spectrometry (sp-ICP-MS). While 3% acetic acid induced significant oxidative dissolution of AgNP to silver ions, there were very minor to no changes in the physicochemical properties of AgNP in water and 10% ethanol. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Addo Ntim, Susana AU - Thomas, Treye A AU - Noonan, Gregory O AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration (USFDA), College Park, MD, USA Y1 - 2016/05/03/ PY - 2016 DA - 2016 May 03 SP - 905 EP - 912 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 5 SN - 1944-0049, 1944-0049 KW - Health & Safety Science Abstracts KW - Risk assessment KW - Ultrafiltration KW - Ions KW - Food additives KW - Fractionation KW - Microscopy KW - Physicochemical properties KW - Mass spectrometry KW - Migration KW - Silver KW - Ethanol KW - H 9000:Consumer and Recreation Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808623735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Influence+of+aqueous+food+simulants+on+potential+nanoparticle+detection+in+migration+studies+involving+nanoenabled+food-contact+substances&rft.au=Addo+Ntim%2C+Susana%3BThomas%2C+Treye+A%3BNoonan%2C+Gregory+O&rft.aulast=Addo+Ntim&rft.aufirst=Susana&rft.date=2016-05-03&rft.volume=33&rft.issue=5&rft.spage=905&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1174506 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Ultrafiltration; Risk assessment; Ions; Food additives; Fractionation; Physicochemical properties; Microscopy; Mass spectrometry; Silver; Migration; Ethanol DO - http://dx.doi.org/10.1080/19440049.2016.1174506 ER - TY - JOUR T1 - Absorption and metabolism of triclosan after application to the skin of B6C3F1 mice AN - 1808380823; PQ0002925220 AB - Triclosan is used as an antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Humans can receive lifelong exposures to triclosan; however, data on the toxicity and carcinogenicity after topical application are lacking. This study determined the absorption, distribution, metabolism, and excretion of triclosan after application to the skin of B6C3F1 mice. [ super(14)C(U)]triclosan (10 or 100 mg triclosan/kg body weight) was administered topically to mice in two separate experiments: a vehicle selection experiment using propylene glycol, ethanol, and a generic cosmetic cream, and a toxicokinetic experiment. Mice were killed up to 72 h after triclosan administration, and excreta and tissues were analyzed for radioactivity. Ethanol had the best properties of the vehicles evaluated. Maximum absorption was obtained at approximately 12 h after dosing. Radioactivity appeared in the excreta and in all tissues examined, with the highest levels in the gall bladder and the lowest levels in the brain. Triclosan was metabolized to triclosan sulfate, triclosan glucuronide, 2,4-dichlorophenol, and hydroxytriclosan. The metabolite profile was tissue-dependent and the predominant route of excretion was fecal. The AUC sub(0-[infin]) and the C sub(max) of plasma and liver in females were greater than those in males. Slightly lower absorption was observed in mice with Elizabethan collars. Environ Toxicol 31: 609-623, 2016. JF - Environmental Toxicology AU - Fang, Jia-Long AU - Vanlandingham, Michelle AU - Costa, Goncalo Gamboa AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, 72079, USA. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 609 EP - 623 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 31 IS - 5 SN - 1520-4081, 1520-4081 KW - Toxicology Abstracts; Pollution Abstracts KW - Sulfates KW - Collars KW - Propylene glycol KW - Consumer products KW - Metabolites KW - Cosmetics KW - Medical equipment KW - Carcinogenicity KW - Absorption KW - Radioactivity KW - 2,4-Dichlorophenol KW - Ethanol KW - Skin KW - Data processing KW - Urinary bladder KW - Brain KW - Mice KW - Toxicity KW - Antimicrobial agents KW - Sulfate KW - Liver KW - Excretion KW - Triclosan KW - Metabolism KW - X 24390:Radioactive Materials KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808380823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology&rft.atitle=Absorption+and+metabolism+of+triclosan+after+application+to+the+skin+of+B6C3F1+mice&rft.au=Fang%2C+Jia-Long%3BVanlandingham%2C+Michelle%3BCosta%2C+Goncalo+Gamboa%3BBeland%2C+Frederick+A&rft.aulast=Fang&rft.aufirst=Jia-Long&rft.date=2016-05-01&rft.volume=31&rft.issue=5&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology&rft.issn=15204081&rft_id=info:doi/10.1002%2Ftox.22074 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Collars; Propylene glycol; Data processing; Skin; Urinary bladder; Brain; Cosmetics; Metabolites; Toxicity; Sulfate; Antimicrobial agents; Carcinogenicity; Liver; Excretion; Radioactivity; Triclosan; Metabolism; Ethanol; 2,4-Dichlorophenol; Sulfates; Consumer products; Mice; Medical equipment; Absorption DO - http://dx.doi.org/10.1002/tox.22074 ER - TY - JOUR T1 - Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice AN - 1805496493; PQ0002910510 AB - Hepatocellular carcinoma (HCC) is one of the most prevalent human cancers, with a rising incidence worldwide. The molecular mechanisms associated with the development of HCC are complex and include multiple interconnected molecular alterations with mounting evidence indicating an important role of microRNAs (miRNAs) in the pathogenesis of HCC. In humans, the development of HCC is commonly associated with liver cirrhosis. To study fibrosis-associated liver carcinogenesis, we used a mouse model designed to emulate the development of HCC in cirrhotic liver. Specifically, we were interested in evaluating the role of miRNAs in the molecular pathogenesis of liver carcinogenesis in male B6C3F1/J mice treated with N-nitrosodiethylamine (DEN) or carbon tetrachloride (CCl sub(4)) alone or a combination of DEN and CCl sub(4) and characterized by a differential tumor incidence that increased in the following order: DEN0.05). However, we found that the VE of WARs was attenuated relative to that of Wistar control animals during exposure to both hypercapnic (WAR: 133 ± 11% vs. Wistar: 243 ± 23%, p<0.01) and hypoxic conditions (WAR: 138 ± 8% vs. Wistar: 177 ± 8%; p<0.01). In addition, we noted that this ventilatory attenuation was followed by alterations in the behavioral responses of these animals. Conclusions Our results indicate that WARs, a genetic model of epilepsy, have important alterations in their ability to compensate for changes in levels of various arterial blood gasses. WARs present an attenuated ventilatory response to an increased PaCO2 or decreased PaO2, coupled to behavioral changes, which make them a suitable model to further study respiratory risks associated to epilepsy. JF - PLoS One AU - Granjeiro, Érica Maria AU - Silva, S Fda AU - Giusti, Humberto AU - Oliveira, José Antonio AU - Glass, Mogens Lesner AU - Garcia-Cairasco, Norberto Y1 - 2016/05// PY - 2016 DA - May 2016 CY - San Francisco PB - Public Library of Science VL - 11 IS - 5 KW - Sciences: Comprehensive Works KW - Rodents KW - Behavior KW - Respiration KW - Ventilation KW - War KW - Studies KW - Experiments KW - Hypoxia KW - Medical research KW - Epilepsy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787084818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=Behavioral%2C+Ventilatory+and+Thermoregulatory+Responses+to+Hypercapnia+and+Hypoxia+in+the+Wistar+Audiogenic+Rat+%28WAR%29+Strain&rft.au=Granjeiro%2C+%C3%89rica+Maria%3BSilva%2C+S+Fda%3BGiusti%2C+Humberto%3BOliveira%2C+Jos%C3%A9+Antonio%3BGlass%2C+Mogens+Lesner%3BGarcia-Cairasco%2C+Norberto&rft.aulast=Granjeiro&rft.aufirst=%C3%89rica&rft.date=2016-05-01&rft.volume=11&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pone.0154141 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - © 2016 Granjeiro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Granjeiro ÉM, da Silva GSF, Giusti H, Oliveira JA, Glass ML, Garcia-Cairasco N (2016) Behavioral, Ventilatory and Thermoregulatory Responses to Hypercapnia and Hypoxia in the Wistar Audiogenic Rat (WAR) Strain. PLoS ONE 11(5): e0154141. doi:10.1371/journal.pone.0154141 N1 - Last updated - 2016-05-07 DO - http://dx.doi.org/10.1371/journal.pone.0154141 ER - TY - JOUR T1 - "Will my work affect my pregnancy?" Resources for anticipating and answering patients' questions. AN - 1785746519; 26976559 AB - Authoritative information on occupational reproductive hazards is scarce and complex because exposure levels vary, multiple exposures may be present, and the reproductive toxicity of many agents remains unknown. For these reasons, women's health providers may find it challenging to effectively address workplace reproductive health issues with their patients who are pregnant, breast-feeding, or considering pregnancy. Reproductive epidemiologists at the Centers for Disease Control and Prevention National Institute for Occupational Safety and Health answered >200 public requests for occupational reproductive health information during 2009 through 2013. The most frequent occupations represented were health care (41%) and laboratory work (18%). The most common requests for exposure information concerned solvents (14%), anesthetic gases (10%), formaldehyde (7%), infectious agents in laboratories (7%) or health care settings (7%), and physical agents (14%), including ionizing radiation (6%). Information for developing workplace policies or guidelines was sought by 12% of the requestors. Occupational exposure effects on breast-feeding were an increasing concern among working women. Based on information developed in response to these requestors, information is provided for discussing workplace exposures with patients, assessing potential workplace reproductive hazards, and helping patients determine the best options for safe work in pregnancy. Appendices provide resources to address specific occupational exposures, employee groups, personal protective equipment, breast-feeding, and workplace regulations regarding work and pregnancy. These tools can help identify those most at risk of occupational reproductive hazards and improve workers' reproductive health. The information can also be used to inform research priorities and assist the development of workplace reproductive health policies. Published by Elsevier Inc. JF - American journal of obstetrics and gynecology AU - Grajewski, Barbara AU - Rocheleau, Carissa M AU - Lawson, Christina C AU - Johnson, Candice Y AD - Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH. Electronic address: bgrajewski1@gmail.com. ; Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH. ; Industrywide Studies Branch, National Institute for Occupational Safety and Health, Cincinnati, OH; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 597 EP - 602 VL - 214 IS - 5 KW - Abridged Index Medicus KW - Index Medicus KW - occupational safety and health KW - pregnancy KW - reproductive health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785746519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=%22Will+my+work+affect+my+pregnancy%3F%22+Resources+for+anticipating+and+answering%C2%A0patients%27+questions.&rft.au=Grajewski%2C+Barbara%3BRocheleau%2C+Carissa+M%3BLawson%2C+Christina+C%3BJohnson%2C+Candice+Y&rft.aulast=Grajewski&rft.aufirst=Barbara&rft.date=2016-05-01&rft.volume=214&rft.issue=5&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/10.1016%2Fj.ajog.2016.03.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-04-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ajog.2016.03.005 ER - TY - JOUR T1 - Prevalence and determinants of insufficient work ability in older HIV-positive and HIV-negative workers AN - 1785244578; PQ0002927802 AB - To explore whether the prevalence and determinants of insufficient work ability (WA) of older HIV-positive workers differ from a comparable group of HIV-negative workers. Cross-sectional data from 359 HIV-negative and 264 HIV-positive middle-aged individuals (45-65 years) participating in paid labor, collected within the AGE sub(h)IV Cohort Study between October 2010-September 2012, were selected. Data were collected by self-administered questionnaires and physical examination. Participants self-rated their current WA, ranging from 0 to 10. WA was dichotomized into insufficient (<6) and sufficient ( greater than or equal to 6). Using univariable and multivariable logistic regression, we studied the independent effect of HIV status on insufficient WA and determinants of insufficient WA. Overall, 8 % of participants reported insufficient WA (HIV-positive 9 vs. HIV-negative 7 %, P = 0.20). Twice as many HIV-positive as HIV-negative individuals were declared partly unfit for work (6 vs. 3 %, P = 0.02). HIV status itself was not associated with WA in univariable and multivariable analyses. Multivariable analyses revealed that low educational level, working fewer hours, being partly unfit for work, experiencing a high need for recovery after work, staying home from work greater than or equal to 2 times in the past 6 months, and reporting depressive symptoms were associated with insufficient WA, independent of HIV status. HIV-positive individuals aged 45-65 years participating in paid labor seem to function as well at work as HIV-negative individuals. HIV-positive participants were more often formally declared partly unfit for work, but percentages were low in both groups. Knowledge of determinants of insufficient WA may help employers and professionals to optimize WA. JF - International Archives of Occupational and Environmental Health AU - Moller, Lisanne M AU - Brands, Ronald AU - Sluiter, Judith K AU - Schouten, Judith AU - Wit, Ferdinand W AU - Reiss, Peter AU - Prins, Maria AU - Stolte, Ineke G AD - Cluster Infectious Diseases, Department of Research, Public Health Service, Amsterdam, Nieuwe Achtergracht 100, 1018 WT, Amsterdam, The Netherlands, mprins@ggd.amsterdam.nl Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 699 EP - 709 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 89 IS - 4 SN - 0340-0131, 0340-0131 KW - Health & Safety Science Abstracts KW - Depression KW - Human immunodeficiency virus KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785244578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=Prevalence+and+determinants+of+insufficient+work+ability+in+older+HIV-positive+and+HIV-negative+workers&rft.au=Moller%2C+Lisanne+M%3BBrands%2C+Ronald%3BSluiter%2C+Judith+K%3BSchouten%2C+Judith%3BWit%2C+Ferdinand+W%3BReiss%2C+Peter%3BPrins%2C+Maria%3BStolte%2C+Ineke+G&rft.aulast=Moller&rft.aufirst=Lisanne&rft.date=2016-05-01&rft.volume=89&rft.issue=4&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/10.1007%2Fs00420-015-1108-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 41 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Depression; Human immunodeficiency virus DO - http://dx.doi.org/10.1007/s00420-015-1108-0 ER - TY - JOUR T1 - Non-thyroid cancer incidence in Belarusian residents exposed to Chernobyl fallout in childhood and adolescence: Standardized Incidence Ratio analysis, 1997-2011 AN - 1785242848; PQ0002920618 AB - Background While an increased risk of thyroid cancer from post-Chernobyl exposure to Iodine-131 (I-131) in children and adolescents has been well-documented, risks of other cancers or leukemia as a result of residence in radioactively contaminated areas remain uncertain. Methods We studied non-thyroid cancer incidence in a cohort of about 12,000 individuals from Belarus exposed under age of 18 years to Chernobyl fallout (median age at the time of Chernobyl accident of 7.9 years). During 15 years of follow-up from1997 through 2011, 54 incident cancers excluding thyroid were identified in the study cohort with 142,968 person-years at risk. We performed Standardized Incidence Ratio (SIR) analysis of all solid cancers excluding thyroid (n=42), of leukemia (n=6) and of lymphoma (n=6). Results We found no significant increase in the incidence of non-thyroid solid cancer (SIR=0.83, 95% Confidence Interval [CI]: 0.61; 1.11), lymphoma (SIR=0.66, 95% CI: 0.26; 1.33) or leukemia (SIR=1.78, 95% CI: 0.71; 3.61) in the study cohort as compared with the sex-, age- and calendar-time-specific national rates. These findings may in part reflect the relatively young age of study subjects (median attained age of 33.4 years), and long latency for some radiation-related solid cancers. Conclusions We found no evidence of statistically significant increases in solid cancer, lymphoma and leukemia incidence 25 years after childhood exposure in the study cohort; however, it is important to continue follow-up non-thyroid cancers in individuals exposed to low-level radiation at radiosensitive ages. JF - Environmental Research AU - Ostroumova, Evgenia AU - Hatch, Maureen AU - Brenner, Alina AU - Nadyrov, Eldar AU - Veyalkin, Ilya AU - Polyanskaya, Olga AU - Yauseyenka, Vasilina AU - Polyakov, Semion AU - Levin, Leonid AU - Zablotska, Lydia AU - Rozhko, Alexander AU - Mabuchi, Kiyohiko AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9609 Medical Center Drive, MSC 9776, Bethesda, 20892 MD, USA Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 44 EP - 49 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 147 SN - 0013-9351, 0013-9351 KW - Toxicology Abstracts; Pollution Abstracts; Environment Abstracts KW - Standardized Incidence Ratio (SIR) KW - Solid cancer KW - Leukemia KW - Lymphoma KW - Chernobyl KW - Belarus KW - Ukraine, Chernobyl KW - Age KW - Statistical analysis KW - Fallout KW - Accidents KW - Radiation KW - thyroid cancer KW - Adolescents KW - Adolescence KW - Thyroid KW - Children KW - Cancer KW - Health risks KW - Nuclear power plants KW - Radioactive fallout KW - Standards KW - X 24390:Radioactive Materials KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785242848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Non-thyroid+cancer+incidence+in+Belarusian+residents+exposed+to+Chernobyl+fallout+in+childhood+and+adolescence%3A+Standardized+Incidence+Ratio+analysis%2C+1997-2011&rft.au=Ostroumova%2C+Evgenia%3BHatch%2C+Maureen%3BBrenner%2C+Alina%3BNadyrov%2C+Eldar%3BVeyalkin%2C+Ilya%3BPolyanskaya%2C+Olga%3BYauseyenka%2C+Vasilina%3BPolyakov%2C+Semion%3BLevin%2C+Leonid%3BZablotska%2C+Lydia%3BRozhko%2C+Alexander%3BMabuchi%2C+Kiyohiko&rft.aulast=Ostroumova&rft.aufirst=Evgenia&rft.date=2016-05-01&rft.volume=147&rft.issue=&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2016.01.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Fallout; Leukemia; Accidents; Age; Radiation; Adolescence; thyroid cancer; Statistical analysis; Children; Lymphoma; Nuclear power plants; Health risks; Radioactive fallout; Thyroid; Standards; Adolescents; Cancer; Belarus; Ukraine, Chernobyl DO - http://dx.doi.org/10.1016/j.envres.2016.01.025 ER - TY - JOUR T1 - Quantitative analysis of the relative mutagenicity of five chemical constituents of tobacco smoke in the mouse lymphoma assay. AN - 1783913209; 26001754 AB - Quantifying health-related biological effects, like genotoxicity, could provide a way of distinguishing between tobacco products. In order to develop tools for using genotoxicty data to quantitatively evaluate the risk of tobacco products, we tested five carcinogens found in cigarette smoke, 4-aminobiphenyl (4-ABP), benzo[a]pyrene (BaP), cadmium (in the form of CdCl2), 2-amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline (MeIQ) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in the mouse lymphoma assay (MLA). The resulting mutagenicity dose responses were analyzed by various quantitative approaches and their strengths and weaknesses for distinguishing responses in the MLA were evaluated. L5178Y/Tk (+/-) 3.7.2C mouse lymphoma cells were treated with four to seven concentrations of each chemical for 4h. Only CdCl2 produced a positive response without metabolic activation (S9); all five chemicals produced dose-dependent increases in cytotoxicity and mutagenicity with S9. The lowest dose exceeding the global evaluation factor, the benchmark dose producing a 10%, 50%, 100% or 200% increase in the background frequency (BMD10, BMD50, BMD100 and BMD200), the no observed genotoxic effect level (NOGEL), the lowest observed genotoxic effect level (LOGEL) and the mutagenic potency expressed as a mutant frequency per micromole of chemical, were calculated for all the positive responses. All the quantitative metrics had similar rank orders for the agents' ability to induce mutation, from the most to least potent as CdCl2(-S9) > BaP(+S9) > CdCl2(+S9) > MeIQ(+S9) > 4-ABP(+S9) > NNK(+S9). However, the metric values for the different chemical responses (i.e. the ratio of the greatest value to the least value) for the different chemicals ranged from 16-fold (BMD10) to 572-fold (mutagenic potency). These results suggest that data from the MLA are capable of discriminating the mutagenicity of various constituents of cigarette smoke, and that quantitative analyses are available that can be useful in distinguishing between the exposure responses. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society 2015. JF - Mutagenesis AU - Guo, Xiaoqing AU - Heflich, Robert H AU - Dial, Stacey L AU - Richter, Patricia A AU - Moore, Martha M AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA and. ; Center for Tobacco Products, Silver Spring, MD 20993, USA Present address: Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA 30341, USA; ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA and Ramboll Environ, 124 West Capitol Avenue, Suite 1890, Little Rock, AR 72201, USA. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA and nan.mei@fda.hhs.gov. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 287 EP - 296 VL - 31 IS - 3 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1783913209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Quantitative+analysis+of+the+relative+mutagenicity+of+five+chemical+constituents+of+tobacco+smoke+in+the+mouse+lymphoma+assay.&rft.au=Guo%2C+Xiaoqing%3BHeflich%2C+Robert+H%3BDial%2C+Stacey+L%3BRichter%2C+Patricia+A%3BMoore%2C+Martha+M%3BMei%2C+Nan&rft.aulast=Guo&rft.aufirst=Xiaoqing&rft.date=2016-05-01&rft.volume=31&rft.issue=3&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgev039 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-04-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/gev039 ER - TY - JOUR T1 - High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress. AN - 1782832812; 27034412 AB - Astrocytes are the predominant cell type in the nervous system and play a significant role in maintaining neuronal health and homeostasis. Recently, astrocyte dysfunction has been implicated in the pathogenesis of many neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. Astrocytes are thus an attractive new target for drug discovery for neurological disorders. Using astrocytes differentiated from human embryonic stem cells, we have developed an assay to identify compounds that protect against oxidative stress, a condition associated with many neurodegenerative diseases. This phenotypic oxidative stress assay has been optimized for high-throughput screening in a 1,536-well plate format. From a screen of approximately 4,100 bioactive tool compounds and approved drugs, we identified a set of 22 that acutely protect human astrocytes from the consequences of hydrogen peroxide-induced oxidative stress. Nine of these compounds were also found to be protective of induced pluripotent stem cell-differentiated astrocytes in a related assay. These compounds are thought to confer protection through hormesis, activating stress-response pathways and preconditioning astrocytes to handle subsequent exposure to hydrogen peroxide. In fact, four of these compounds were found to activate the antioxidant response element/nuclear factor-E2-related factor 2 pathway, a protective pathway induced by toxic insults. Our results demonstrate the relevancy and utility of using astrocytes differentiated from human stem cells as a disease model for drug discovery and development. Astrocytes play a key role in neurological diseases. Drug discovery efforts that target astrocytes can identify novel therapeutics. Human astrocytes are difficult to obtain and thus are challenging to use for high-throughput screening, which requires large numbers of cells. Using human embryonic stem cell-derived astrocytes and an optimized astrocyte differentiation protocol, it was possible to screen approximately 4,100 compounds in titration to identify 22 that are cytoprotective of astrocytes. This study is the largest-scale high-throughput screen conducted using human astrocytes, with a total of 17,536 data points collected in the primary screen. The results demonstrate the relevancy and utility of using astrocytes differentiated from human stem cells as a disease model for drug discovery and development. ©AlphaMed Press. JF - Stem cells translational medicine AU - Thorne, Natasha AU - Malik, Nasir AU - Shah, Sonia AU - Zhao, Jean AU - Class, Bradley AU - Aguisanda, Francis AU - Southall, Noel AU - Xia, Menghang AU - McKew, John C AU - Rao, Mahendra AU - Zheng, Wei AD - National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA Natasha.Thorne@fda.hhs.gov wzheng@mail.nih.gov. ; Laboratory of Stem Cell Biology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA. ; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA. ; NIH Center for Regenerative Medicine, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 613 EP - 627 VL - 5 IS - 5 SN - 2157-6564, 2157-6564 KW - Antioxidants KW - 0 KW - NF-E2-Related Factor 2 KW - NFE2L2 protein, human KW - Oxidants KW - Small Molecule Libraries KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Stem cells KW - Astrocytes KW - Oxidative stress KW - High-throughput screening KW - Neurodegenerative disease KW - Antioxidant Response Elements -- drug effects KW - Oxidants -- pharmacology KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Humans KW - NF-E2-Related Factor 2 -- genetics KW - Cytoprotection KW - NF-E2-Related Factor 2 -- metabolism KW - Hydrogen Peroxide -- toxicity KW - Phenotype KW - Hep G2 Cells KW - Gene Expression Regulation, Developmental KW - Neurogenesis KW - Embryonic Stem Cells -- metabolism KW - Embryonic Stem Cells -- drug effects KW - Antioxidants -- pharmacology KW - Astrocytes -- drug effects KW - Oxidative Stress -- drug effects KW - High-Throughput Screening Assays -- methods KW - Drug Discovery -- methods KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1782832812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+cells+translational+medicine&rft.atitle=High-Throughput+Phenotypic+Screening+of+Human+Astrocytes+to+Identify+Compounds+That+Protect+Against+Oxidative+Stress.&rft.au=Thorne%2C+Natasha%3BMalik%2C+Nasir%3BShah%2C+Sonia%3BZhao%2C+Jean%3BClass%2C+Bradley%3BAguisanda%2C+Francis%3BSouthall%2C+Noel%3BXia%2C+Menghang%3BMcKew%2C+John+C%3BRao%2C+Mahendra%3BZheng%2C+Wei&rft.aulast=Thorne&rft.aufirst=Natasha&rft.date=2016-05-01&rft.volume=5&rft.issue=5&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Stem+cells+translational+medicine&rft.issn=21576564&rft_id=info:doi/10.5966%2Fsctm.2015-0170 LA - English DB - ProQuest Environmental Science Collection N1 - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.5966/sctm.2015-0170 ER - TY - JOUR T1 - Presymptomatic MPTP Mice Show Neurotrophic S100B/mRAGE Striatal Levels. AN - 1781534983; 26843141 AB - Astrocytic S100B and receptor for advanced glycation endproducts (RAGE) have been implicated in Parkinson׳s disease (PD) pathogenesis through yet unclear mechanisms. This study attempted to characterize S100B/mRAGE (signaling isoform) axis in a dying-back dopaminergic (DAergic) axonopathy setting, which mimics an early event of PD pathology. C57BL/6 mice were submitted to a chronic MPTP paradigm (20 mg/kg i.p., 2 i.d-12 h apart, 5 days/week for 2 weeks) and euthanized 7 days posttreatment to assess mRAGE cellular distribution and S100B/mRAGE density in striatum, after probing their locomotor activity (pole test and rotarod). Dopaminergic status, oxidative stress, and gliosis were also measured (HPLC-ED, WB, IHC). This MPTP regimen triggered increased oxidative stress (augmented HNE levels), gliosis (GS/Iba1-reactive morphology), loss of DAergic fibers (decreased tyrosine hydroxylase levels), and severe hypodopaminergia. Biochemical deficits were not translated into motor abnormalities, mimicking a presymptomatic PD period. Remarkably, striatal neurotrophic S100B/mRAGE levels and major neuronal mRAGE localization coexist with compensatory responses (3-fold increase in DA turnover), which are important to maintain normal motor function. Our findings rule out the involvement of S100B/mRAGE axis in striatal reactive gliosis, DAergic axonopathy and warrant further exploration of its neurotrophic effects in a presymptomatic compensatory PD stage, which is a fundamental period for successful implementation of therapeutic strategies. © 2016 John Wiley & Sons Ltd. JF - CNS neuroscience & therapeutics AU - Viana, Sofia D AU - Fernandes, Rosa C AU - Canas, Paula M AU - Silva, Andréa M AU - Carvalho, Félix AU - Ali, Syed F AU - Fontes Ribeiro, Carlos A AU - Pereira, Frederico C AD - Laboratory of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. ; UCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR, USA. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 396 EP - 403 VL - 22 IS - 5 KW - Advanced Glycosylation End Product-Specific Receptor KW - 0 KW - Aldehydes KW - S100 Calcium Binding Protein beta Subunit KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - 4-hydroxy-2-nonenal KW - K1CVM13F96 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Presymptomatic KW - S100B KW - MPTP KW - RAGE KW - Striatum KW - Hypokinesia -- physiopathology KW - Animals KW - Hypokinesia -- pathology KW - Tyrosine 3-Monooxygenase -- metabolism KW - Disease Models, Animal KW - Dopamine -- metabolism KW - Mice KW - Gliosis -- pathology KW - Rotarod Performance Test KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- pharmacology KW - Oxidative Stress -- drug effects KW - Mice, Inbred C57BL KW - Aldehydes -- metabolism KW - Motor Activity -- drug effects KW - Gene Expression Regulation -- drug effects KW - Gliosis -- chemically induced KW - Male KW - Advanced Glycosylation End Product-Specific Receptor -- genetics KW - S100 Calcium Binding Protein beta Subunit -- genetics KW - Corpus Striatum -- metabolism KW - Corpus Striatum -- drug effects KW - Advanced Glycosylation End Product-Specific Receptor -- metabolism KW - MPTP Poisoning -- pathology KW - S100 Calcium Binding Protein beta Subunit -- metabolism KW - MPTP Poisoning -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1781534983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CNS+neuroscience+%26+therapeutics&rft.atitle=Presymptomatic+MPTP+Mice+Show+Neurotrophic+S100B%2FmRAGE+Striatal+Levels.&rft.au=Viana%2C+Sofia+D%3BFernandes%2C+Rosa+C%3BCanas%2C+Paula+M%3BSilva%2C+Andr%C3%A9a+M%3BCarvalho%2C+F%C3%A9lix%3BAli%2C+Syed+F%3BFontes+Ribeiro%2C+Carlos+A%3BPereira%2C+Frederico+C&rft.aulast=Viana&rft.aufirst=Sofia&rft.date=2016-05-01&rft.volume=22&rft.issue=5&rft.spage=396&rft.isbn=&rft.btitle=&rft.title=CNS+neuroscience+%26+therapeutics&rft.issn=1755-5949&rft_id=info:doi/10.1111%2Fcns.12508 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-16 N1 - Date created - 2016-04-15 N1 - Date revised - 2017-01-24 N1 - Last updated - 2017-01-25 DO - http://dx.doi.org/10.1111/cns.12508 ER - TY - JOUR T1 - Health Literacy Among People with Serious Mental Illness AN - 1781528798 AB - People diagnosed with a mental illness are at higher risk of developing preventable chronic diseases; thus, health literacy improvements may have great potential to impact health outcomes for this typically underserved population. However, there is a dearth of research on health literacy of persons with severe mental illness. The purpose of this research was to investigate aspects of health literacy and identify factors associated with low literacy among adults with severe mental illness using three literacy assessment tools. Seventy-one adults with serious mental illness were assessed and a high proportion had limited literacy levels: 42 % with the Single Item Literacy Screener, 50 % with the Rapid Estimate of Adult Literacy in Medicine-Short Form, and 67 % with the Newest Vital Sign. Findings suggest that individuals with certain mental illnesses and lower functioning may have more difficulty understanding health information and have limited numerical literacy. JF - Community Mental Health Journal AU - Clausen, Whitney AU - Watanabe-galloway, Shinobu AU - Bill Baerentzen, M AU - Britigan, Denise H AD - Division of Public Health, Nebraska Department of Health and Human Services, Lincoln, NE, USA ; College of Public Health, University of Nebraska Medical Center, Omaha, NE, USA ; Community Alliance, Omaha, NE, USA Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 399 EP - 405 CY - New York PB - Springer Science & Business Media VL - 52 IS - 4 SN - 0010-3853 KW - Psychology KW - Health literacy KW - Severe mental illness KW - Community setting KW - Single Item Literacy Screener (SILS) KW - Rapid Estimate of Adult Literacy in Medicine-Short form (REALM-SF) KW - Newest Vital Sign (NVS) KW - Health Problems KW - Medicine KW - Terminal Illness KW - Mental Illness KW - Health KW - Risk KW - Health Research KW - Literacy KW - Diseases KW - Medical research KW - Mentally ill people KW - Sickness KW - Chronic diseases KW - Health education KW - Health information KW - Health status KW - Avoidable KW - Risk assessment KW - Adults KW - Mental illness KW - Underserved people KW - 6142:mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1781528798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Health+Literacy+Among+People+with+Serious+Mental+Illness&rft.au=Clausen%2C+Whitney%3BWatanabe-galloway%2C+Shinobu%3BBill+Baerentzen%2C+M%3BBritigan%2C+Denise+H&rft.aulast=Clausen&rft.aufirst=Whitney&rft.date=2016-05-01&rft.volume=52&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-015-9951-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Social Services Abstracts N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Last updated - 2016-08-16 DO - http://dx.doi.org/10.1007/s10597-015-9951-8 ER - TY - JOUR T1 - Screening for toxic phorbol esters in jerky pet treat products using LC-MS. AN - 1780510016; 27038400 AB - Since 2007, the U.S. FDA's Center for Veterinary Medicine (CVM) has been investigating reports of pets becoming ill after consuming jerky pet treats. Jerky used in pet treats contains glycerin, which can be made from vegetable oil or as a byproduct of biodiesel production. Because some biodiesel is produced using oil from Jatropha curcas, a plant that contains toxic compounds including phorbol esters, CVM developed a liquid chromatography-mass spectrometry (LC-MS) screening method to evaluate investigational jerky samples for the presence of these toxins. Results indicated that the samples analyzed with the new method did not contain Jatropha toxins at or above the lowest concentration tested. Published by Elsevier B.V. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Nishshanka, Upul AU - Jayasuriya, Hiranthi AU - Chattopadhaya, Chaitali AU - Kijak, Philip J AU - Chu, Pak-Sin AU - Reimschuessel, Renate AU - Tkachenko, Andriy AU - Ceric, Olgica AU - De Alwis, Hemakanthi G AD - Division of Residue Chemistry, Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA. ; Veterinary Laboratory Investigation & Response Network, Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA. ; Division of Residue Chemistry, Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Road, Laurel, MD 20708, USA. Electronic address: hemakanthi.dealwis@fda.hhs.gov. Y1 - 2016/05/01/ PY - 2016 DA - 2016 May 01 SP - 90 EP - 95 VL - 1020 KW - Biofuels KW - 0 KW - Phorbol Esters KW - Plant Oils KW - Index Medicus KW - Jerky pet treats KW - High resolution KW - Phorbol esters KW - LC–MS method KW - Jatropha curcas KW - Accurate mass KW - Plant Oils -- chemistry KW - Linear Models KW - Jatropha -- chemistry KW - Biofuels -- analysis KW - Phorbol Esters -- chemistry KW - Chromatography, Liquid -- methods KW - Phorbol Esters -- analysis KW - Animal Feed -- analysis KW - Mass Spectrometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780510016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=Screening+for+toxic+phorbol+esters+in+jerky+pet+treat+products+using+LC-MS.&rft.au=Nishshanka%2C+Upul%3BJayasuriya%2C+Hiranthi%3BChattopadhaya%2C+Chaitali%3BKijak%2C+Philip+J%3BChu%2C+Pak-Sin%3BReimschuessel%2C+Renate%3BTkachenko%2C+Andriy%3BCeric%2C+Olgica%3BDe+Alwis%2C+Hemakanthi+G&rft.aulast=Nishshanka&rft.aufirst=Upul&rft.date=2016-05-01&rft.volume=1020&rft.issue=&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=1873-376X&rft_id=info:doi/10.1016%2Fj.jchromb.2016.03.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-04-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Nat Prod. 2002 Oct;65(10):1434-40 [12398539] J Toxicol Environ Health B Crit Rev. 2010 Aug;13(6):476-507 [20711929] Fitoterapia. 2012 Apr;83(3):586-92 [22245089] Cancer Res. 1988 Oct 15;48(20):5800-4 [3167837] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jchromb.2016.03.023 ER - TY - JOUR T1 - Impact of Low Maternal Education on Early Childhood Overweight and Obesity in Europe. AN - 1778399800; 26945670 AB - Comparable evidence on adiposity inequalities in early life is lacking across a range of European countries. This study investigates whether low maternal education is associated with overweight and obesity risk in children from distinct European settings during early childhood. Prospective data of 45 413 children from 11 European cohorts were used. Children's height and weight obtained at ages 4-7 years were used to assess prevalent overweight and obesity according to the International Obesity Task Force definition. The Relative/Slope Indices of Inequality (RII/SII) were estimated within each cohort and by gender to investigate adiposity risk among children born to mothers with low education as compared to counterparts born to mothers with high education. Individual-data meta-analyses were conducted to obtain aggregate estimates and to assess heterogeneity between cohorts. Low maternal education yielded a substantial risk of early childhood adiposity across 11 European countries. Low maternal education yielded a mean risk ratio of 1.58 (95% confidence interval (CI) 1.34, 1.85) and a mean risk difference of 7.78% (5.34, 10.22) in early childhood overweight, respectively, measured by the RII and SII. Early childhood obesity risk by low maternal education was as substantial for all cohorts combined (RII = 2.61 (2.10, 3.23)) and (SII = 4.01% (3.14, 4.88)). Inequalities in early childhood adiposity were consistent among boys, but varied among girls in a few cohorts. Considerable inequalities in overweight and obesity are evident among European children in early life. Tackling early childhood adiposity is necessary to promote children's immediate health and well-being and throughout the life course. © 2016 John Wiley & Sons Ltd. JF - Paediatric and perinatal epidemiology AU - Ruiz, Milagros AU - Goldblatt, Peter AU - Morrison, Joana AU - Porta, Daniela AU - Forastiere, Francesco AU - Hryhorczuk, Daniel AU - Antipkin, Youriy AU - Saurel-Cubizolles, Marie-Josèphe AU - Lioret, Sandrine AU - Vrijheid, Martine AU - Torrent, Maties AU - Iñiguez, Carmen AU - Larrañaga, Isabel AU - Bakoula, Chryssa AU - Veltsista, Alexandra AU - van Eijsden, Manon AU - Vrijkotte, Tanja G M AU - Andrýsková, Lenka AU - Dušek, Ladislav AU - Barros, Henrique AU - Correia, Sofia AU - Järvelin, Marjo-Riitta AU - Taanila, Anja AU - Ludvigsson, Johnny AU - Faresjö, Tomas AU - Marmot, Michael AU - Pikhart, Hynek AD - Research Department of Epidemiology and Public Health, University College London, London, UK. ; Research Department of Epidemiology and Public Health, UCL Institute of Health Equity, University College London, London, UK. ; Department of Epidemiology, Lazio Regional Health System, Rome, Italy. ; Center for Global Health, University of Illinois College of Medicine, Chicago, IL, USA. ; Institute of Pediatrics, Obstetrics, and Gynecology, Kyiv, Ukraine. ; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics, Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris, France. ; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1153, Early Origin of the Child's Health and Development Team (ORCHAD), Center for Epidemiology and Statistics, Sorbonne Paris Cité, Paris Descartes University, Paris, France. ; Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. ; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain. ; FISABIO - Universitat Jaume I - Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Castellón de la Plana, Spain. ; Public Health Department of Gipuzkoa, Gipuzkoa, Spain. ; First Department of Paediatrics, Aghia Sophia Children's Hospital, University of Athens, Athens, Greece. ; Department of Epidemiology and Health Promotion, Public Health Service of Amsterdam, Amsterdam, The Netherlands. ; Department of Public Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. ; Faculty of Science, Research Centre of Toxic Compounds in the Environment (RECETOX), Masaryk University, Brno, Czech Republic. ; EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal. ; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE), Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. ; Institute of Health Sciences, University of Oulu, Oulu, Finland. ; Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. ; Department of Medicine and Health, Community Medicine/General Practice Faculty of Health Sciences, Linköping University, Linköping, Sweden. Y1 - 2016/05// PY - 2016 DA - May 2016 SP - 274 EP - 284 VL - 30 IS - 3 KW - Index Medicus KW - child development KW - Portugal KW - Greece KW - Finland KW - Spain KW - Ukraine KW - obesity KW - epidemiology KW - Europe KW - cohort studies KW - United Kingdom KW - Italy KW - child KW - France KW - meta-analysis KW - comparative study KW - Czech Republic KW - overweight KW - maternal educational status KW - Netherlands KW - preschool KW - health inequalities KW - Sweden KW - Humans KW - Cross-Cultural Comparison KW - Infant, Newborn KW - Europe -- epidemiology KW - Child, Preschool KW - Pregnancy KW - Socioeconomic Factors KW - Infant KW - Prospective Studies KW - Risk Factors KW - Adult KW - Female KW - Male KW - Prevalence KW - Educational Status KW - Mothers -- statistics & numerical data KW - Pediatric Obesity -- prevention & control KW - Maternal Behavior -- psychology KW - Mothers -- psychology KW - Pediatric Obesity -- etiology KW - Pediatric Obesity -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1778399800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Paediatric+and+perinatal+epidemiology&rft.atitle=Impact+of+Low+Maternal+Education+on+Early+Childhood+Overweight+and+Obesity+in+Europe.&rft.au=Ruiz%2C+Milagros%3BGoldblatt%2C+Peter%3BMorrison%2C+Joana%3BPorta%2C+Daniela%3BForastiere%2C+Francesco%3BHryhorczuk%2C+Daniel%3BAntipkin%2C+Youriy%3BSaurel-Cubizolles%2C+Marie-Jos%C3%A8phe%3BLioret%2C+Sandrine%3BVrijheid%2C+Martine%3BTorrent%2C+Maties%3BI%C3%B1iguez%2C+Carmen%3BLarra%C3%B1aga%2C+Isabel%3BBakoula%2C+Chryssa%3BVeltsista%2C+Alexandra%3Bvan+Eijsden%2C+Manon%3BVrijkotte%2C+Tanja+G+M%3BAndr%C3%BDskov%C3%A1%2C+Lenka%3BDu%C5%A1ek%2C+Ladislav%3BBarros%2C+Henrique%3BCorreia%2C+Sofia%3BJ%C3%A4rvelin%2C+Marjo-Riitta%3BTaanila%2C+Anja%3BLudvigsson%2C+Johnny%3BFaresj%C3%B6%2C+Tomas%3BMarmot%2C+Michael%3BPikhart%2C+Hynek&rft.aulast=Ruiz&rft.aufirst=Milagros&rft.date=2016-05-01&rft.volume=30&rft.issue=3&rft.spage=274&rft.isbn=&rft.btitle=&rft.title=Paediatric+and+perinatal+epidemiology&rft.issn=1365-3016&rft_id=info:doi/10.1111%2Fppe.12285 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-02 N1 - Date created - 2016-04-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/ppe.12285 ER - TY - JOUR T1 - Are meat and heme iron intake associated with pancreatic cancer? Results from the NIH-AARP diet and health cohort. AN - 1767623951; 26666579 AB - Several studies on pancreatic cancer have reported significant positive associations for intake of red meat but null associations for heme iron. We assessed total, red, white and processed meat intake, meat cooking methods and doneness and heme iron and mutagen intake in relation to pancreatic cancer in the NIH-AARP Diet and Health Study cohort. A total of 322,846 participants (187,265 men and 135,581 women) successfully completed and returned the food frequency questionnaire between 1995 and 1996. After a mean follow-up of 9.2 years (up to 10.17 years), 1,417 individuals (895 men and 522 women) developed exocrine pancreatic cancer. Cox proportional hazard models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), and trends were calculated using the median value of each quantile. Models incorporated age as the time metric and were adjusted for smoking history, body mass index, self-reported diabetes and energy-adjusted saturated fat. Pancreatic cancer risk significantly increased with intake of total meat (Q5 vs. Q1: HR = 1.20, 95% CI 1.02-1.42, p-trend = 0.03), red meat (HR = 1.22, 95% CI 1.01-1.48, p-trend = 0.02), high-temperature cooked meat (HR = 1.21, 95% CI 1.00-1.45, p-trend = 0.02), grilled/barbequed meat (HR = 1.24, 95% CI 1.03-1.50, p-trend = 0.007), well/very well done meat (HR = 1.32, 95% CI 1.10-1.58, p-trend = 0.005) and heme iron from red meat (Q4 vs. Q1: HR = 1.21, 95% CI 1.01-1.45, p-trend = 0.04). When stratified by sex, these associations remained significant in men but not women except for white meat intake in women (HR = 1.33, 95% CI 1.02-1.74, p-trend = 0.04). Additional studies should confirm our findings that consuming heme iron from red meat increases pancreatic cancer risk. © 2015 UICC. JF - International journal of cancer AU - Taunk, Pulkit AU - Hecht, Eric AU - Stolzenberg-Solomon, Rachael AD - Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL. ; Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD. Y1 - 2016/05/01/ PY - 2016 DA - 2016 May 01 SP - 2172 EP - 2189 VL - 138 IS - 9 KW - Iron, Dietary KW - 0 KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - pancreatic cancer KW - meat KW - heme iron KW - Risk Factors KW - Humans KW - Cooking KW - Cohort Studies KW - Diet Surveys KW - Aged KW - Middle Aged KW - Heme -- adverse effects KW - Male KW - Female KW - Proportional Hazards Models KW - Heme -- administration & dosage KW - Meat -- adverse effects KW - Iron, Dietary -- adverse effects KW - Pancreatic Neoplasms -- epidemiology KW - Diet KW - Feeding Behavior KW - Iron, Dietary -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1767623951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Are+meat+and+heme+iron+intake+associated+with+pancreatic+cancer%3F+Results+from+the+NIH-AARP+diet+and+health+cohort.&rft.au=Taunk%2C+Pulkit%3BHecht%2C+Eric%3BStolzenberg-Solomon%2C+Rachael&rft.aulast=Taunk&rft.aufirst=Pulkit&rft.date=2016-05-01&rft.volume=138&rft.issue=9&rft.spage=2172&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.29964 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-18 N1 - Date created - 2016-02-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Nutr Food Res. 2005 Jul;49(7):648-55 [15986387] Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):655-61 [17416754] Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2664-75 [18086772] PLoS Med. 2007 Dec;4(12):e325 [18076279] Int J Cancer. 2009 Sep 1;125(5):1118-26 [19452526] Am J Epidemiol. 2010 Jan 15;171(2):233-41 [20022893] Ann Oncol. 2011 Jan;22(1):202-6 [20530201] Cancer Epidemiol Biomarkers Prev. 2011 Apr;20(4):711-4 [21278328] Mol Carcinog. 2012 Jan;51(1):128-37 [22162237] Cancer Epidemiol. 2012 Feb;36(1):60-7 [22018953] Br J Cancer. 2012 Jan 31;106(3):603-7 [22240790] Cancer Epidemiol Biomarkers Prev. 2012 Apr;21(4):619-28 [22301828] Surg Oncol. 2014 Jun;23(2):61-71 [24746917] Am J Clin Nutr. 2015 Jan;101(1):126-34 [25527756] Am J Epidemiol. 2000 Aug 1;152(3):279-86 [10933275] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Mutat Res. 2002 Sep 30;506-507:225-31 [12351162] Am J Epidemiol. 2003 Jun 15;157(12):1115-25 [12796048] J Natl Cancer Inst. 2003 Jul 2;95(13):948-60 [12837831] Mutat Res. 1975 Dec;31(6):347-64 [768755] Int J Cancer. 1991 Jan 2;47(1):1-6 [1845960] Am J Epidemiol. 1991 Jul 15;134(2):167-79 [1862800] Cancer Causes Control. 1991 Sep;2(5):291-7 [1932541] Int J Epidemiol. 1993 Feb;22(1):30-7 [8449644] Cancer Res. 1995 Oct 15;55(20):4516-9 [7553619] Int J Cancer. 2012 Oct 1;131(7):E1134-47 [22438075] Carcinogenesis. 2013 Jul;34(7):1628-35 [23455377] Cancer Epidemiol Biomarkers Prev. 2013 Jul;22(7):1336-9 [23632817] Br J Cancer. 2013 Aug 6;109(3):756-60 [23695021] Am J Clin Nutr. 2013 Oct;98(4):1057-65 [23985810] Nutr J. 2013;12:102 [23866833] CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29 [24399786] Meat Sci. 2014 Aug;97(4):583-96 [24769880] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Food Chem Toxicol. 1998 Apr;36(4):289-97 [9651045] J Natl Cancer Inst. 1998 Nov 18;90(22):1710-9 [9827525] J Gastroenterol. 2005 Mar;40(3):297-301 [15830290] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ijc.29964 ER - TY - JOUR T1 - Intravenous administration of silver nanoparticles causes organ toxicity through intracellular ROS-related loss of inter-endothelial junction. AN - 1786517511; 27129495 AB - Administration of silver nanoparticles (AgNPs) to mice could result in their distribution and accumulation in multiple organs, with notable prominence in liver, lungs, and kidneys. However, how AgNPs transport through blood vesicular system to reach the target organs is unclear, and the precise differences in the mechanisms of toxicity between AgNPs and silver ions still remain elusive. In the present research, the pathological changes on these target organs with a focus on inter-endothelial junction was investigated to gain a new insight of AgNPs toxicity by comparing the mechanisms of action of AgNPs and AgNO3. We investigated the in vitro cytotoxicity of either citrated-coated AgNPs (10, 75, and 110 nm) or silver nitrate (AgNO3) following 24 h incubations (1-40 μg/mL) in the presence of primary human umbilical vein endothelial cells (HUVEC). Meanwhile, we detected the effects of AgNPs on intercellular conjunction and intracellular ROS by VE-cadherin staining and 2', 7'-dichlorodihydrofluorescein diacetate (DCFH-DA) assay, respectively. To assess in vivo toxicity, we administered single or multiple intravenous injections (25 μg Ag for AgNPs and 2.5 μg Ag for AgNO3 per dose) to mice. In the in vitro study, the TEM observation showed that AgNPs were taken up by endothelial cells while AgNO3 was taken up little. Meanwhile AgNPs incubation induced the elevation of intracellular ROS and down-regulation of VE-cadherin between the endothelial cells and affected the cytoskeleton actin reorganization, which could be rescued by antioxidant N-acetylcysteine. In contrast, AgNO3 caused direct cell death when the concentration was higher than 20 μg/mL and without ROS induction at lower concentration. The release of AgNPs from leaking vessels induced peripheral inflammation in the liver, lungs, and kidneys, and the severity increased in proportion to the diameter of the AgNPs used. It is AgNPs but not AgNO3 that were taken up by vascular endothelial cells and induced intracellular ROS elevated, which was closely related to disruption of the integrity of endothelial layer. The AgNPs-induced leakiness of endothelial cells could mediate the common peripheral inflammation in liver, kidney and lung through intravenous exposure. JF - Particle and fibre toxicology AU - Guo, Hua AU - Zhang, Jing AU - Boudreau, Mary AU - Meng, Jie AU - Yin, Jun-jie AU - Liu, Jian AU - Xu, Haiyan AD - Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, 20740, USA. ; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. liujian@ibms.pumc.edu.cn. ; Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. xuhy@pumc.edu.cn. Y1 - 2016/04/29/ PY - 2016 DA - 2016 Apr 29 SP - 21 VL - 13 KW - Antigens, CD KW - 0 KW - Antioxidants KW - Cadherins KW - Reactive Oxygen Species KW - cadherin 5 KW - Silver KW - 3M4G523W1G KW - Silver Nitrate KW - 95IT3W8JZE KW - Index Medicus KW - Silver nitrate KW - ROS KW - Peripheral inflammation KW - Silver nanoparticles KW - Inter-endothelial junctions KW - Animals KW - Cadherins -- metabolism KW - Chemical and Drug Induced Liver Injury -- pathology KW - Humans KW - Liver -- metabolism KW - Mice, Inbred BALB C KW - Pneumonia -- pathology KW - Risk Assessment KW - Cytoskeleton -- drug effects KW - Permeability KW - Chemical and Drug Induced Liver Injury -- etiology KW - Antioxidants -- pharmacology KW - Liver -- drug effects KW - Nephritis -- chemically induced KW - Cytoskeleton -- pathology KW - Kidney -- blood supply KW - Time Factors KW - Nephritis -- pathology KW - Nephritis -- metabolism KW - Pneumonia -- chemically induced KW - Kidney -- metabolism KW - Liver -- blood supply KW - Silver Nitrate -- toxicity KW - Cytoskeleton -- metabolism KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Kidney -- drug effects KW - Lung -- metabolism KW - Lung -- blood supply KW - Cells, Cultured KW - Antigens, CD -- metabolism KW - Lung -- drug effects KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Pneumonia -- metabolism KW - Female KW - Reactive Oxygen Species -- metabolism KW - Human Umbilical Vein Endothelial Cells -- drug effects KW - Intercellular Junctions -- pathology KW - Intercellular Junctions -- metabolism KW - Human Umbilical Vein Endothelial Cells -- metabolism KW - Human Umbilical Vein Endothelial Cells -- pathology KW - Silver -- toxicity KW - Oxidative Stress -- drug effects KW - Silver -- administration & dosage KW - Intercellular Junctions -- drug effects KW - Metal Nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1786517511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Particle+and+fibre+toxicology&rft.atitle=Intravenous+administration+of+silver+nanoparticles+causes+organ+toxicity+through+intracellular+ROS-related+loss+of+inter-endothelial+junction.&rft.au=Guo%2C+Hua%3BZhang%2C+Jing%3BBoudreau%2C+Mary%3BMeng%2C+Jie%3BYin%2C+Jun-jie%3BLiu%2C+Jian%3BXu%2C+Haiyan&rft.aulast=Guo&rft.aufirst=Hua&rft.date=2016-04-29&rft.volume=13&rft.issue=&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Particle+and+fibre+toxicology&rft.issn=1743-8977&rft_id=info:doi/10.1186%2Fs12989-016-0133-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-11 N1 - Date created - 2016-04-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: FEBS Lett. 2002 Jan 2;510(1-2):62-6 [11755532] J Cell Sci. 2002 May 1;115(Pt 9):1837-46 [11956315] Free Radic Biol Med. 1999 Jul;27(1-2):146-59 [10443931] Appl Environ Microbiol. 2008 Apr;74(7):2171-8 [18245232] Crit Rev Toxicol. 2010 Apr;40(4):328-46 [20128631] Biomaterials. 2010 Nov;31(32):8350-61 [20684985] Toxicol Mech Methods. 2011 Jan;21(1):13-24 [21080782] Int Dent J. 2011 Dec;61(6):297-301 [22117785] Environ Toxicol Chem. 2012 Jan;31(1):155-9 [22012883] ACS Nano. 2012 May 22;6(5):3745-59 [22482460] J Appl Toxicol. 2012 Nov;32(11):890-9 [22522906] J Appl Toxicol. 2012 Nov;32(11):920-8 [22696427] Toxicol Lett. 2012 Nov 15;214(3):251-8 [22982066] Nanotoxicology. 2012 Dec;6:912-22 [22023110] Nanoscale. 2013 Jan 21;5(2):463-74 [23203029] Toxicol In Vitro. 2013 Mar;27(2):739-44 [23246472] Curr Med Chem. 2013 Feb 1;20(6):772-81 [23298139] Nat Commun. 2013;4:1673 [23575677] Aquat Toxicol. 2013 Aug 15;138-139:123-8 [23728357] Biometals. 2013 Aug;26(4):609-21 [23771576] Biomaterials. 2013 Nov;34(33):8333-43 [23886731] Curr Pharm Des. 2013;19(37):6691-7 [23621535] Crit Rev Microbiol. 2013 Nov;39(4):373-83 [22928774] Nanotoxicology. 2014 Sep;8(6):686-96 [23837638] Toxicology. 2014 Jan 6;315:86-91 [24321264] Regul Toxicol Pharmacol. 2014 Feb;68(1):1-7 [24231525] J Food Drug Anal. 2014 Mar;22(1):116-27 [24673909] Drug Metab Rev. 2014 May;46(2):224-31 [24378227] PLoS One. 2014;9(4):e95340 [24755991] Reprod Toxicol. 2014 Jun;45:59-70 [24447867] Acta Odontol Scand. 2014 Aug;72(6):413-7 [24325608] Nanotoxicology. 2014 Aug;8 Suppl 1:36-45 [24266757] Anal Chem. 2014 Aug 19;86(16):8267-74 [25025651] PLoS One. 2014;9(9):e106711 [25184212] Food Chem Toxicol. 2015 Mar;77:58-63 [25556118] Nanomedicine. 2015 Apr;11(3):731-9 [25546848] Drug Discov Today. 2015 May;20(5):595-601 [25543008] Eur Arch Otorhinolaryngol. 2015 Oct;272(10):2629-42 [25082176] J Membr Biol. 1988 Apr;102(1):11-9 [2456393] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12989-016-0133-9 ER - TY - JOUR T1 - Status of hepatic DNA methylome predetermines and modulates the severity of non-alcoholic fatty liver injury in mice. AN - 1783914531; 27103143 AB - Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and Western countries. In humans, genetic factors greatly influence individual susceptibility to NAFLD; nonetheless, the effect of inter-individual differences in the normal liver epigenome with regard to the susceptibility to NAFLD has not been determined. In the present study, we investigated the association between the DNA methylation status in the livers of A/J and WSB/EiJ mice and the severity of NAFLD-associated liver injury. We demonstrate that A/J and WSB/EiJ mice, which are characterized by significant differences in the severity of liver injury induced by a choline- and folate-deficient (CFD) diet exhibit substantial differences in cytosine DNA methylation in their normal livers. Furthermore, feeding A/J and WSB/EiJ mice a CFD diet for 12 weeks resulted in different trends and changes in hepatic cytosine DNA methylation. Our findings indicate a primary role of hepatic DNA methylation in the pathogenesis of NAFLD and suggest that individual variations in DNA methylation across the genome may be a factor determining and influencing the vulnerability to NAFLD. JF - BMC genomics AU - Tryndyak, Volodymyr P AU - Han, Tao AU - Fuscoe, James C AU - Ross, Sharon A AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Rd, Jefferson, AR, 72079, USA. ; Division of Systems Biology, National Center for Toxicological Research, FDA, Jefferson, AR, USA. ; Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, 3900 NCTR Rd, Jefferson, AR, 72079, USA. igor.pogribny@fda.hhs.gov. Y1 - 2016/04/22/ PY - 2016 DA - 2016 Apr 22 SP - 298 VL - 17 KW - Histones KW - 0 KW - Cytosine KW - 8J337D1HZY KW - Folic Acid KW - 935E97BOY8 KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA (cytosine-5-)-methyltransferase 1 KW - DNA methyltransferase 3A KW - Choline KW - N91BDP6H0X KW - Index Medicus KW - Inter-strain differences KW - DNA methylation KW - Non-alcoholic fatty liver injury KW - Mouse KW - Susceptibility KW - Mice, Inbred Strains KW - Mice, Inbred A KW - Animals KW - Cytosine -- chemistry KW - Histones -- metabolism KW - CpG Islands KW - Mice KW - Diet KW - DNA (Cytosine-5-)-Methyltransferase -- metabolism KW - Non-alcoholic Fatty Liver Disease -- genetics KW - Liver -- physiopathology KW - DNA Methylation KW - Epigenesis, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1783914531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Status+of+hepatic+DNA+methylome+predetermines+and+modulates+the+severity+of+non-alcoholic+fatty+liver+injury+in+mice.&rft.au=Tryndyak%2C+Volodymyr+P%3BHan%2C+Tao%3BFuscoe%2C+James+C%3BRoss%2C+Sharon+A%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Tryndyak&rft.aufirst=Volodymyr&rft.date=2016-04-22&rft.volume=17&rft.issue=&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2Fs12864-016-2617-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-09 N1 - Date created - 2016-04-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cell Metab. 2013 Aug 6;18(2):296-302 [23931760] Gut. 2013 Sep;62(9):1356-63 [22879518] Liver Int. 2014 Feb;34(2):281-95 [23834235] Hepatology. 2014 Feb;59(2):471-82 [23913408] Arch Toxicol. 2014 Apr;88(4):967-82 [24469900] Int J Mol Sci. 2014;15(5):8591-638 [24830559] J Hum Genet. 2014 May;59(5):241-6 [24621583] Hepatology. 2015 Feb;61(2):515-25 [25302781] J Hepatol. 2015 May;62(5):1148-55 [25477264] Gastroenterology. 2015 May;148(5):1012-1023.e14 [25701738] J Hepatol. 2015 Apr;62(1 Suppl):S65-75 [25920092] PLoS One. 2015;10(5):e0127991 [26017539] Cell Metab. 2015 Jun 2;21(6):905-17 [26039453] JAMA. 2015 Jun 9;313(22):2263-73 [26057287] J Hepatol. 2015 Aug;63(2):494-502 [25776890] Sci Rep. 2015;5:12931 [26263022] Semin Liver Dis. 2015 Aug;35(3):270-90 [26378644] Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S46-50 [26160474] J Dig Dis. 2015 Oct;16(10):541-57 [26406351] Hepatology. 2004 Dec;40(6):1266-74 [15562441] Nat Protoc. 2008;3(6):1101-8 [18546601] J Hepatol. 2009 Jul;51(1):176-86 [19450891] Methods Mol Biol. 2009;563:379-98 [19597796] Gastroenterology. 2010 Nov;139(5):1567-76, 1576.e1-6 [20708005] Gene. 2011 Mar 1;473(2):150-6 [21167261] Expert Rev Gastroenterol Hepatol. 2011 Apr;5(2):253-63 [21476920] Nature. 2011 May 5;473(7345):43-9 [21441907] Antioxid Redox Signal. 2011 Jul 15;15(2):535-50 [21126212] Science. 2011 Jun 24;332(6037):1519-23 [21700865] PLoS One. 2012;7(1):e30014 [22238690] Gastroenterol Hepatol. 2012 Jan;35(1):32-41 [22093607] J Mol Med (Berl). 2012 Feb;90(2):105-18 [21894552] J Hepatol. 2012 Jun;56(6):1384-91 [22326465] Toxicol Appl Pharmacol. 2012 Jul 1;262(1):52-9 [22561871] FASEB J. 2012 Nov;26(11):4592-602 [22872676] Biochim Biophys Acta. 2013 Apr;1831(4):803-18 [23318274] Gastroenterology. 2013 Nov;145(5):1076-87 [23916847] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12864-016-2617-2 ER - TY - JOUR T1 - Evaluation of cephamycins as supplements to selective agar for detecting Campylobacter spp. in chicken carcass rinses. AN - 1770879046; 26915052 AB - Although cefoperazone is the most commonly used antibiotic in Campylobacter-selective media, the distribution of cefoperazone-resistant bacteria such as extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli is increasing. Here we evaluated the potential of cephamycins for use as supplements to improve modified charcoal-cefoperazone-deoxycholate agar (mCCDA) by replacing cefoperazone with the same concentrations (32 mg/L) of cefotetan (modified charcoal-cefotetan-deoxycholate agar, mCCtDA) and cefoxitin (modified charcoal-cefoxitin-deoxycholate agar, mCCxDA). In chicken carcass rinse samples, the number of mCCDA plates detecting for Campylobacter (18/70, 26%) was significantly lower than that of mCCtDA (42/70, 60%) or mCCxDA plates (40/70, 57%). The number of mCCDA plates (70/70, 100%) that were contaminated with non-Campylobacter species was significantly higher than that of mCCtDA (20/70, 29%) or mCCxDA plates (21/70, 30%). The most common competing species identified using mCCDA was ESBL-producing E. coli, while Pseudomonas species frequently appeared on mCCtDA and mCCxDA. Copyright © 2016. Published by Elsevier B.V. JF - International journal of food microbiology AU - Chon, Jung-Whan AU - Kim, Young-Ji AU - Kim, Hong-Seok AU - Kim, Dong-Hyeon AU - Kim, Hyunsook AU - Song, Kwang-Young AU - Sung, Kidon AU - Seo, Kun-Ho AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Center for One Health, College of Veterinary Medicine, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea. ; Department of Food & Nutrition College of Human Ecology, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea. ; Center for One Health, College of Veterinary Medicine, Konkuk University, Hwayang-dong, Gwangjin-gu, Seoul 05029, Republic of Korea. Electronic address: bracstu3@konkuk.ac.kr. Y1 - 2016/04/16/ PY - 2016 DA - 2016 Apr 16 SP - 75 EP - 78 VL - 223 KW - Anti-Bacterial Agents KW - 0 KW - Cephamycins KW - Culture Media KW - Agar KW - 9002-18-0 KW - Index Medicus KW - Chicken KW - Campylobacter KW - ESBL KW - Cefoxitin KW - Cefotetan KW - Animals KW - Anti-Bacterial Agents -- pharmacology KW - Agar -- chemistry KW - Chickens -- microbiology KW - Bacteriological Techniques -- methods KW - Campylobacter -- drug effects KW - Cephamycins -- pharmacology KW - Culture Media -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770879046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Evaluation+of+cephamycins+as+supplements+to+selective+agar+for+detecting+Campylobacter+spp.+in+chicken+carcass+rinses.&rft.au=Chon%2C+Jung-Whan%3BKim%2C+Young-Ji%3BKim%2C+Hong-Seok%3BKim%2C+Dong-Hyeon%3BKim%2C+Hyunsook%3BSong%2C+Kwang-Young%3BSung%2C+Kidon%3BSeo%2C+Kun-Ho&rft.aulast=Chon&rft.aufirst=Jung-Whan&rft.date=2016-04-16&rft.volume=223&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=1879-3460&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2016.01.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-19 N1 - Date created - 2016-03-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2016.01.019 ER - TY - JOUR T1 - Mechanistically linked serum miRNAs distinguish between drug induced and fatty liver disease of different grades. AN - 1779438593; 27045805 AB - Hepatic steatosis is characterised by excessive triglyceride accumulation in the form of lipid droplets (LD); however, mechanisms differ in drug induced (DIS) and/or non-alcoholic fatty liver disease (NAFLD). Here we hypothesized distinct molecular circuits of microRNA/LD-associated target genes and searched for mechanistically linked serum and tissue biomarkers that would distinguish between DIS and human NAFLD of different grades. We analysed >800 rat hepatic whole genome data for 17 steatotic drugs and identified 157 distinct miRNAs targeting 77 DIS regulated genes. Subsequently, genomic data of N = 105 cases of human NAFLD and N = 32 healthy controls were compared to serum miRNA profiles of N = 167 NAFLD patients. This revealed N = 195 tissue-specific miRNAs being mechanistically linked to LD-coding genes and 24 and 9 miRNAs were commonly regulated in serum and tissue of advanced and mild NAFLD, respectively. The NASH serum regulated miRNAs informed on hepatic inflammation, adipocytokine and insulin signalling, ER-and caveolae associated activities and altered glycerolipid metabolism. Conversely, serum miRNAs associated with blunt steatosis specifically highlighted activity of FOXO1&HNF4α on CPT2, the lipid droplet and ER-lipid-raft associated PLIN3 and Erlin1. Altogether, serum miRNAs informed on the molecular pathophysiology of NAFLD and permitted differentiation between DIS and NAFLD of different grades. JF - Scientific reports AU - Liu, Zhichao AU - Wang, Yuping AU - Borlak, Jürgen AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. ; Centre for Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. Y1 - 2016/04/05/ PY - 2016 DA - 2016 Apr 05 SP - 23709 VL - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1779438593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Mechanistically+linked+serum+miRNAs+distinguish+between+drug+induced+and+fatty+liver+disease+of+different+grades.&rft.au=Liu%2C+Zhichao%3BWang%2C+Yuping%3BBorlak%2C+J%C3%BCrgen%3BTong%2C+Weida&rft.aulast=Liu&rft.aufirst=Zhichao&rft.date=2016-04-05&rft.volume=6&rft.issue=&rft.spage=23709&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep23709 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-04-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Nutr Biochem. 2014 Dec;25(12):1235-42 [25256357] Toxicol Sci. 2014 Dec;142(2):321-30 [25466379] PLoS One. 2014;9(12):e113651 [25470250] PLoS Genet. 2014 Dec;10(12):e1004789 [25502566] Liver Transpl. 2015 Jan;21(1):123-31 [25307969] J Clin Pharm Ther. 2015 Feb;40(1):110-5 [25250564] Cell Physiol Biochem. 2014;34(6):1983-97 [25562147] Nucleic Acids Res. 2015 Jan;43(Database issue):D921-7 [25313160] World J Gastroenterol. 2015 Jan 14;21(2):511-6 [25593466] Expert Rev Mol Diagn. 2015 Feb;15(2):219-34 [25455156] Nature. 2010 Aug 12;466(7308):835-40 [20703300] J Biol Chem. 2010 Oct 1;285(40):31011-23 [20610391] Arch Biochem Biophys. 2010 Dec 15;504(2):221-7 [20831858] Lab Invest. 2011 Feb;91(2):283-93 [20956972] Curr Opin Lipidol. 2011 Apr;22(2):86-92 [21178770] Exp Cell Res. 2011 Jul 15;317(12):1714-25 [21586285] Expert Opin Drug Metab Toxicol. 2011 Aug;7(8):949-65 [21510823] J Lipid Res. 2011 Aug;52(8):1517-25 [21633093] BMJ. 2011;343:d3897 [21768191] PLoS One. 2011;6(8):e23937 [21886843] Hepatology. 2011 Nov;54(5):1767-76 [22045675] Biochem Biophys Res Commun. 2011 Nov 4;414(4):664-9 [21986524] J Gastroenterol Hepatol. 2012 Feb;27(2):331-40 [21793903] PLoS One. 2012;7(2):e30250 [22363424] Nat Rev Gastroenterol Hepatol. 2012 Mar;9(3):152-61 [22249728] J Hepatol. 2012 Apr;56(4):952-64 [22173168] Cancer. 2012 May 1;118(9):2431-42 [21989846] J Nutr Biochem. 2012 Jun;23(6):622-8 [21764575] Hepatology. 2012 Jun;55(6):2005-23 [22488764] Toxicol Appl Pharmacol. 2012 Jul 1;262(1):52-9 [22561871] J Lipid Res. 2012 Jul;53(7):1287-95 [22534642] World J Gastroenterol. 2012 Oct 7;18(37):5188-96 [23066312] Mol Nutr Food Res. 2012 Nov;56(11):1665-74 [22968990] Hepatology. 2012 Nov;56(5):1631-40 [22610915] PLoS One. 2012;7(10):e48366 [23152743] World J Gastroenterol. 2012 Dec 7;18(45):6546-51 [23236228] J Hepatol. 2013 Jan;58(1):119-25 [22902550] Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15 [23203871] Cell Metab. 2013 Aug 6;18(2):296-302 [23931760] PLoS One. 2013;8(8):e72324 [23991091] Clin Chim Acta. 2013 Sep 23;424:99-103 [23727030] J Biol Chem. 2013 Sep 13;288(37):26569-82 [23897822] Eur J Cancer. 2013 Nov;49(16):3442-9 [23810247] Int J Mol Sci. 2013;14(12):24154-68 [24351808] J Biol Chem. 2013 Dec 27;288(52):37082-93 [24196965] Nucleic Acids Res. 2014 Jan;42(Database issue):D68-73 [24275495] Nucleic Acids Res. 2014 Jan;42(Database issue):D78-85 [24304892] Gut. 2014 Feb;63(2):344-55 [23492103] Hepatology. 2014 Feb;59(2):471-82 [23913408] FASEB J. 2014 Feb;28(2):836-48 [24249635] Genes Dev. 2014 Mar 1;28(5):438-50 [24532687] Genes Dev. 2014 Apr 15;28(8):858-74 [24736844] Diabetes Res Clin Pract. 2013 Mar;99(3):327-34 [23287814] Gastroenterology. 2013 Jun;144(7):1419-25, 1425.e1-3; quiz e19-20 [23419359] Liver Int. 2015 Feb;35(2):532-41 [25040043] Int J Mol Med. 2015 Mar;35(3):847-53 [25605429] Am J Physiol Gastrointest Liver Physiol. 2015 Feb 15;308(4):G298-312 [25501551] J Lipid Res. 2015 Mar;56(3):722-36 [25598080] J Hepatol. 2015 Apr;62(4):889-96 [25450715] PLoS One. 2015;10(3):e0118417 [25799309] Gut. 2015 May;64(5):800-12 [24973316] Biochim Biophys Acta. 2015 Jul;1852(7):1550-9 [25916635] Nutrients. 2015 May;7(5):3483-96 [25984739] Clin Chim Acta. 2015 Jun 15;446:267-71 [25958847] Clin Res Hepatol Gastroenterol. 2015 Jun;39(3):359-65 [25543521] Int J Biochem Cell Biol. 2015 Jul;64:265-76 [25957914] Exp Cell Res. 2015 Aug 1;336(1):33-42 [26033364] Transl Res. 2015 Sep;166(3):304-14 [26001595] J Hepatol. 2015 Dec;63(6):1466-75 [26272872] JAMA. 2003 Jun 11;289(22):3000-4 [12799409] BMC Bioinformatics. 2003 Jan 13;4:2 [12525261] Gastroenterology. 1999 Jun;116(6):1413-9 [10348825] Atherosclerosis. 2007 Apr;191(2):235-40 [16970951] FEBS Lett. 2007 Jul 10;581(17):3157-63 [17583696] Nat Rev Genet. 2008 Feb;9(2):102-14 [18197166] Biol Chem. 2008 Mar;389(3):305-12 [18177263] Hepatology. 2008 Dec;48(6):1810-20 [19030170] Cell. 2009 Feb 20;136(4):642-55 [19239886] Gastroenterology. 2009 Mar;136(3):1081-90 [19185580] Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4402-7 [19246379] Biochem Biophys Res Commun. 2009 Aug 7;385(4):492-6 [19460359] Hepatology. 2009 Oct;50(4):1152-61 [19711427] N Engl J Med. 2009 Oct 8;361(15):1437-47 [19812400] J Lipid Res. 2009 Sep;50(9):1756-65 [19372595] J Gastroenterol Hepatol. 2010 Jan;25(1):156-63 [19780876] PLoS One. 2010;5(3):e9570 [20221393] Aliment Pharmacol Ther. 2010 Aug;32(3):487-97 [20497147] Gastroenterology. 2010 Aug;139(2):653-63 [20303349] J Gastroenterol Hepatol. 2013 Aug;28(8):1410-5 [23663110] Hepatology. 2013 Aug;58(2):777-87 [23390034] Prog Lipid Res. 2014 Apr;54:86-112 [24607340] J Appl Toxicol. 2014 Jun;34(6):726-32 [24217942] J Mol Cell Biol. 2014 Jun;6(3):214-30 [24815299] Nature. 2014 Jun 5;510(7503):115-20 [24899310] Liver Int. 2014 Aug;34(7):e302-7 [24313922] Hepatology. 2014 Aug;60(2):554-64 [24677249] Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):455 [24981726] PLoS One. 2014;9(8):e105192 [25141008] Mol Med Rep. 2014 Dec;10(6):3080-6 [25269746] Cancer Sci. 2014 Oct;105(10):1254-60 [25117675] J Mol Endocrinol. 2014 Dec;53(3):393-403 [25312970] World J Gastroenterol. 2014 Nov 7;20(41):15343-50 [25386083] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep23709 ER - TY - JOUR T1 - Aloe vera: A review of toxicity and adverse clinical effects AN - 1808739958; PQ0003206355 AB - The Aloe plant is employed as a dietary supplement in a variety of foods and as an ingredient in cosmetic products. The widespread human exposure and its potential toxic and carcinogenic activities raise safety concerns. Chemical analysis reveals that the Aloe plant contains various polysaccharides and phenolic chemicals, notably anthraquinones. Ingestion of Aloe preparations is associated with diarrhea, hypokalemia, pseudomelanosis coli, kidney failure, as well as phototoxicity and hypersensitive reactions. Recently, Aloe vera whole leaf extract showed clear evidence of carcinogenic activity in rats, and was classified by the International Agency for Research on Cancer as a possible human carcinogen (Group 2B). This review presents updated information on the toxicological effects, including the cytotoxicity, genotoxicity, carcinogenicity, and adverse clinical effects of Aloe vera whole leaf extract, gel, and latex. JF - Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews AU - Guo, Xiaoqing AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, USA Y1 - 2016/04/02/ PY - 2016 DA - 2016 Apr 02 SP - 77 EP - 96 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 34 IS - 2 SN - 1059-0501, 1059-0501 KW - Environment Abstracts; Toxicology Abstracts KW - Food KW - Cosmetics KW - Carcinogens KW - Polysaccharides KW - Rats KW - Phototoxicity KW - Aloe vera KW - Carcinogenicity KW - Hypokalemia KW - phenolic compounds KW - Diarrhea KW - Aloe KW - anthraquinone KW - Safety KW - Genotoxicity KW - Leaves KW - Renal failure KW - Latex KW - Toxicity KW - Ingestion KW - Cancer KW - Cytotoxicity KW - Reviews KW - Dietary supplements KW - Carcinogenesis KW - Kidney KW - X 24340:Cosmetics, Toiletries & Household Products KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808739958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.atitle=Aloe+vera%3A+A+review+of+toxicity+and+adverse+clinical+effects&rft.au=Guo%2C+Xiaoqing%3BMei%2C+Nan&rft.aulast=Guo&rft.aufirst=Xiaoqing&rft.date=2016-04-02&rft.volume=34&rft.issue=2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.issn=10590501&rft_id=info:doi/10.1080%2F10590501.2016.1166826 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Diarrhea; anthraquinone; Food; Genotoxicity; Leaves; Renal failure; Cosmetics; Latex; Carcinogens; Polysaccharides; Cancer; Phototoxicity; Cytotoxicity; Dietary supplements; Reviews; Carcinogenesis; Hypokalemia; phenolic compounds; Safety; Toxicity; Ingestion; Rats; Carcinogenicity; Kidney; Aloe vera; Aloe DO - http://dx.doi.org/10.1080/10590501.2016.1166826 ER - TY - JOUR T1 - Method development and survey of Sudan I-IV in palm oil and chilli spices in the Washington, DC, area AN - 1790933310; PQ0003046988 AB - Sudan I, II, III and IV dyes are banned for use as food colorants in the United States and European Union because they are toxic and carcinogenic. These dyes have been illegally used as food additives in products such as chilli spices and palm oil to enhance their red colour. From 2003 to 2005, the European Union made a series of decisions requiring chilli spices and palm oil imported to the European Union to contain analytical reports declaring them free of Sudan I-IV. In order for the USFDA to investigate the adulteration of palm oil and chilli spices with unapproved colour additives in the United States, a method was developed for the extraction and analysis of Sudan dyes in palm oil, and previous methods were validated for Sudan dyes in chilli spices. Both LC-DAD and LC-MS/MS methods were examined for their limitations and effectiveness in identifying adulterated samples. Method validation was performed for both chilli spices and palm oil by spiking samples known to be free of Sudan dyes at concentrations close to the limit of detection. Reproducibility, matrix effects, and selectivity of the method were also investigated. Additionally, for the first time a survey of palm oil and chilli spices was performed in the United States, specifically in the Washington, DC, area. Illegal dyes, primarily Sudan IV, were detected in palm oil at concentrations from 150 to 24 000 ng ml super(-1). Low concentrations (< 21 mu g kg super(-1)) of Sudan dyes were found in 11 out of 57 spices and are most likely a result of cross-contamination during preparation and storage and not intentional adulteration. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Genualdi, Susie AU - MacMahon, Shaun AU - Robbins, Katherine AU - Farris, Samantha AU - Shyong, Nicole AU - DeJager, Lowri AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration (USFDA), College Park, MD, USA Y1 - 2016/04/02/ PY - 2016 DA - 2016 Apr 02 SP - 583 EP - 591 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 4 SN - 1944-0049, 1944-0049 KW - Chemoreception Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - USA, Washington D.C. KW - Spices KW - Sudan KW - Food contamination KW - Firing pattern KW - Storage KW - Oil KW - Food additives KW - European Union KW - Dyes KW - Carcinogenicity KW - Additives KW - R 18065:Food science KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790933310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Method+development+and+survey+of+Sudan+I-IV+in+palm+oil+and+chilli+spices+in+the+Washington%2C+DC%2C+area&rft.au=Genualdi%2C+Susie%3BMacMahon%2C+Shaun%3BRobbins%2C+Katherine%3BFarris%2C+Samantha%3BShyong%2C+Nicole%3BDeJager%2C+Lowri&rft.aulast=Genualdi&rft.aufirst=Susie&rft.date=2016-04-02&rft.volume=33&rft.issue=4&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1147986 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Oil; Food additives; Dyes; Spices; Food contamination; Firing pattern; Storage; European Union; Carcinogenicity; Additives; USA, Washington D.C.; Sudan DO - http://dx.doi.org/10.1080/19440049.2016.1147986 ER - TY - JOUR T1 - In Vitro Tests for Aerosol Deposition. IV: Simulating Variations in Human Breath Profiles for Realistic DPI Testing AN - 1859494326; PQ0003988672 AB - Background: The amount of drug aerosol from an inhaler that can pass through an in vitro model of the mouth and throat (MT) during a realistic breath or inhalation flow rate vs. time profile (IP) is designated the total lung dose in vitro, or TLDin vitro. This article describes a clinical study that enabled us to recommend a general method of selecting IPs for use with powder inhalers of known airflow resistance (R) provided subjects followed written instructions either alone or in combination with formal training. Methods: In a drug-free clinical trial, inhaler-naive, nonsmoking healthy adult human volunteers were screened for normal pulmonary function. IPs were collected from each volunteer inhaling through different air flow resistances after different levels of training. IPs were analyzed to determine the distribution of inhalation variables across the population and their dependence on training and airflow resistance. Results: Equations for IP simulation are presented that describe the data including confidence limits at each resistance and training condition. Realistic IPs at upper (90%), median (50%), and lower (10%) confidence limits were functions of R and training. Peak inspiratory flow rates (PIFR) were inversely proportional to R so that if R was assigned, values for PIFR could be calculated. The time of PIFR, TPIFR, and the total inhaled volume (V) were unrelated to R, but dependent on training. Once R was assigned for a powder inhaler to be tested, a range of simulated IPs could be generated for the different training scenarios. Values for flow rate acceleration and depth of inspiration could also be varied within the population limits of TPIFR and V. Conclusions: The use of simulated IPs, in concert with realistic in vitro testing, should improve the DPI design process and the confidence with which clinical testing may be initiated for a chosen device. JF - Journal of Aerosol Medicine and Pulmonary Drug Delivery AU - Delvadia, Renishkumar R AU - Wei, Xiangyin AU - Longest, PWorth AU - Venitz, Jurgen AU - Byron, Peter R AD - Food and Drug Administration, Rockville, Maryland. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 196 EP - 206 PB - Mary Ann Liebert, Inc., 140 Huguenot St 3rd Fl New Rochelle NY 10801 United States VL - 29 IS - 2 SN - 1941-2711, 1941-2711 KW - Biotechnology and Bioengineering Abstracts KW - airflow resistance KW - dry powder inhaler KW - in vitro-in vivo correlations KW - inhalation profiles KW - patient training KW - peak inhalation flow rate KW - realistic inhaler testing KW - Inhalation KW - Drug delivery KW - Powder KW - Aerosols KW - Pharynx KW - Mathematical models KW - Data processing KW - Respiration KW - Clinical trials KW - Models KW - Lung KW - Mouth KW - Air flow KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1859494326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Aerosol+Medicine+and+Pulmonary+Drug+Delivery&rft.atitle=In+Vitro+Tests+for+Aerosol+Deposition.+IV%3A+Simulating+Variations+in+Human+Breath+Profiles+for+Realistic+DPI+Testing&rft.au=Delvadia%2C+Renishkumar+R%3BWei%2C+Xiangyin%3BLongest%2C+PWorth%3BVenitz%2C+Jurgen%3BByron%2C+Peter+R&rft.aulast=Delvadia&rft.aufirst=Renishkumar&rft.date=2016-04-01&rft.volume=29&rft.issue=2&rft.spage=196&rft.isbn=&rft.btitle=&rft.title=Journal+of+Aerosol+Medicine+and+Pulmonary+Drug+Delivery&rft.issn=19412711&rft_id=info:doi/10.1089%2Fjamp.2015.1215 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Number of references - 22 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Inhalation; Powder; Drug delivery; Aerosols; Data processing; Mathematical models; Pharynx; Respiration; Clinical trials; Models; Lung; Mouth; Air flow DO - http://dx.doi.org/10.1089/jamp.2015.1215 ER - TY - RPRT T1 - Table of contents AN - 1827585866 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/04// PY - 2016 DA - Apr 2016 SP - 4 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827585866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-04-01&rft.volume=&rft.issue=585&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Apr 2016 N1 - Last updated - 2016-10-11 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF GREEN TEA EXTRACT IN F344/NTac RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF GREEN TEA EXTRACT IN WISTAR HAN[Crl:WI(Han)] RATS AND B6C3F1/N MICE (GAVAGE STUDIES) AN - 1827585428 AB - Concentrated extracts from the leaves of the plant Camellia sinensis are used in nutraceutical supplements for weight loss and as ingredients in sunblocks and other cosmetics. We studied the effects of a green tea extract on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing green tea extract in water through a tube directly into the stomach to groups of 50 male and female rats and mice 5 days per week for 2 years. Exposed rats received daily doses of either 100, 300, or 1,000 milligrams of green tea extract per kilogram of body weight, and exposed mice received 30, 100, or 300 mg/kg. Control animals received water with no chemical added by the same method. At the end of the study, tissues from more than 40 sites were examined for every animal. No increased incidences of tumors related to green tea extract were observed in rats or mice of either sex. A variety of non-cancerous lesions was observed in each study, however. A spectrum of lesions of the nose, including suppurative inflammation, olfactory epithelium atrophy, epithelial hyperplasia, and epithelial metaplasia was seen in all groups of rats and mice exposed to green tea extract. Necrosis of the liver, stomach, and small intestine; inflammation of the epicardium (heart); suppurative inflammation of the lung, and lymphoid depletion of the spleen occurred in male and female rats receiving green tea extract, and hyperplasia of the mandibular lymph node and bone marrow was markedly increased in male and female mice receiving green tea extract. The incidence of bone marrow hyperplasia was increased in female rats and the incidences of liver inflammation and hematopoietic cell proliferation were increased in male mice. We conclude that green tea extract did not cause cancer at any site in male or female rats or mice. Nonneoplastic lesions of the nose, liver, stomach, small intestine, heart, lung, bone marrow (females), and spleen in male and female rats and of the nose, liver (males), mandibular lymph node, and bone marrow in male and female mice were associated with administration of green tea extract. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/04// PY - 2016 DA - Apr 2016 SP - 1 EP - 15,17-27,29-39,41-105,107-137,139-155,157-163,165-171,173-191 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Liver KW - Carcinogens KW - Tumors KW - Rodents KW - Animal behavior UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827585428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+GREEN+TEA+EXTRACT+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+GREEN+TEA+EXTRACT+IN+WISTAR+HAN%5BCrl%3AWI%28Han%29%5D+RATS+AND+B6C3F1%2FN+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-04-01&rft.volume=&rft.issue=585&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Apr 2016 N1 - Document feature - References; Photographs; Illustrations; Tables; Graphs N1 - Last updated - 2016-10-11 ER - TY - RPRT T1 - FOREWORD AN - 1827585377 AB - The National Toxicology Program (NTP) is an interagency program within the Public Health Service (PHS) of the Department of Health and Human Services (HHS) and is headquartered at the National Institute of Environmental Health Sciences of the National Institutes of Health (NIEHS/NIH). JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/04// PY - 2016 DA - Apr 2016 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Public health KW - Health services KW - Laboratory animals KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827585377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-04-01&rft.volume=&rft.issue=585&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Name - Food & Drug Administration--FDA; Department of Health & Human Services N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Apr 2016 N1 - Last updated - 2016-10-11 ER - TY - JOUR T1 - Redefining Residential: Ensuring Competent Residential Interventions for Youth with Diverse Gender and Sexual Identities and Expressions AN - 1816898844 AB - ACRC recognizes that all children and adolescents are complex human beings, who may bring to their care with the residential treatment centers many forms of diversity, including diversity of sexual orientation (SO) and gender identity (GI). It is incumbent upon residential treatment centers to ensure that these diversity issues are treated with linguistic and cultural competence in all aspects of these client's treatment from admission through discharge planning. Crucial to delivering high-quality care requires focusing on the intentional creation of safe space, staff training, affirming policies and procedures, and increasing family acceptance. JF - Residential Treatment for Children & Youth AU - Glick, Douglas A AU - Krishnan, Mira C AU - Fisher, Sylvia K AU - Lieberman, Robert E AU - Sisson, Kari AD - United Methodist Family Services, Richmond, Virginia ; Hope Network & Behavioral Health, Grand Rapids, Michigan ; Health Resources and Services Administration (HRSA), Rockville, Maryland ; Kairos, Grants Pass, Oregon ; Association of Children's Residential Centers (ACRC), Milwaukee, Wisconsin ; United Methodist Family Services, Richmond, Virginia Y1 - 2016///Apr/Jun PY - 2016 DA - Apr/Jun 2016 SP - 107 EP - 117 CY - Binghamton PB - Taylor & Francis Ltd. VL - 33 IS - 2 SN - 0886-571X KW - Children And Youth - About KW - ACRC KW - residential intervention KW - LGBTQI2-S KW - sexual diversity KW - Cultural competence KW - Training KW - Cultural Sensitivity KW - Acceptance KW - Cultural Pluralism KW - Competence KW - Sexual Preferences KW - Sex Role Identity KW - Youth KW - Children KW - Adolescents KW - Quality of Health Care KW - Residential Institutions KW - Linguistic competence KW - Discharge planning KW - Diversity KW - Residential treatment KW - Sexual orientation KW - Gender identity KW - Care delivery KW - Quality of care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1816898844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Residential+Treatment+for+Children+%26+Youth&rft.atitle=Redefining+Residential%3A+Ensuring+Competent+Residential+Interventions+for+Youth+with+Diverse+Gender+and+Sexual+Identities+and+Expressions&rft.au=Glick%2C+Douglas+A%3BKrishnan%2C+Mira+C%3BFisher%2C+Sylvia+K%3BLieberman%2C+Robert+E%3BSisson%2C+Kari&rft.aulast=Glick&rft.aufirst=Douglas&rft.date=2016-04-01&rft.volume=33&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Residential+Treatment+for+Children+%26+Youth&rft.issn=0886571X&rft_id=info:doi/10.1080%2F0886571X.2016.1205316 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Social Services Abstracts N1 - Copyright - © 2016 Taylor & Francis N1 - Last updated - 2016-09-07 DO - http://dx.doi.org/10.1080/0886571X.2016.1205316 ER - TY - JOUR T1 - Circulating MicroRNA and Long Noncoding RNA as Biomarkers of Cardiovascular Diseases. AN - 1802744859; 26308238 AB - Although >85% of the human genome is transcribed, only 200 nucleotides). It is now clear that these RNAs fulfil critical roles as transcriptional and post-transcriptional regulators and as guides of chromatin-modifying complexes. Although not translated into protein, noncoding RNAs can regulate cardiac function through diverse mechanisms and their dysregulation is increasingly linked with cardiovascular pathophysiology. Furthermore, a series of recent studies have discovered that noncoding RNAs can be found in the bloodstream and some species are remarkably stable. This has raised the possibility that such noncoding RNAs may be measured in body fluids and serve as novel diagnostic biomarkers. Here, we summarize the current knowledge of noncoding RNAs' function and biomarker potential in cardiac diseases, concentrating mainly on circulating miRNAs and lncRNAs. J. Cell. Physiol. 231: 751-755, 2016. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc. JF - Journal of cellular physiology AU - Shi, Qiang AU - Yang, Xi AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 751 EP - 755 VL - 231 IS - 4 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1802744859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Circulating+MicroRNA+and+Long+Noncoding+RNA+as+Biomarkers+of+Cardiovascular+Diseases.&rft.au=Shi%2C+Qiang%3BYang%2C+Xi&rft.aulast=Shi&rft.aufirst=Qiang&rft.date=2016-04-01&rft.volume=231&rft.issue=4&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=1097-4652&rft_id=info:doi/10.1002%2Fjcp.25174 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-07-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jcp.25174 ER - TY - JOUR T1 - High Content Imaging of Early Morphological Signatures Predicts Long Term Mineralization Capacity of Human Mesenchymal Stem Cells upon Osteogenic Induction AN - 1787994680; PQ0002952942 AB - Human bone marrow-derived multipotent mesenchymal stromal cells, often referred to as mesenchymal stem cells (MSCs), represent an attractive cell source for many regenerative medicine applications due to their potential for multi-lineage differentiation, immunomodulation, and paracrine factor secretion. A major complication for current MSC-based therapies is the lack of well-defined characterization methods that can robustly predict how they will perform in a particular in vitro or in vivo setting. Significant advances have been made with identifying molecular markers of MSC quality and potency using multivariate genomic and proteomic approaches, and more recently with advanced techniques incorporating high content imaging to assess high-dimensional single cell morphological data. We sought to expand upon current methods of high dimensional morphological analysis by investigating whether short term cell and nuclear morphological profiles of MSCs from multiple donors (at multiple passages) correlated with long term mineralization upon osteogenic induction. Using the combined power of automated high content imaging followed by automated image analysis, we demonstrated that MSC morphology after 3 days was highly correlated with 35 day mineralization and comparable to other methods of MSC osteogenesis assessment (such as alkaline phosphatase activity). We then expanded on this initial morphological characterization and identified morphological features that were highly predictive of mineralization capacities (>90% accuracy) of MSCs from additional donors and different manufacturing techniques using linear discriminant analysis. Together, this work thoroughly demonstrates the predictive power of MSC morphology for mineralization capacity and motivates further studies into MSC morphology as a predictive marker for additional in vitro and in vivo responses. Stem Cells 2016; 34:935-947 High dimensional early morphological signatures extracted from single cells using high content image analysis can be used to predict mineralization capacity of culture-expanded human mesenchymal stem cells. The top left panel shows day 3 images for cellular and nuclear morphology analysis. Principal component analysis and linear discriminant analysis are used to develop morphology-based models that accurately (>90%) predict mineralization. JF - Stem Cells AU - Marklein, Ross A AU - Lo Surdo, Jessica L AU - Bellayr, Ian H AU - Godil, Saniya A AU - Puri, Raj K AU - Bauer, Steven R AD - Cellular and Tissue Therapies Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 935 EP - 947 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 34 IS - 4 SN - 1066-5099, 1066-5099 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - stromal cells KW - Paracrine signalling KW - Bone marrow KW - Image processing KW - Mineralization KW - Immunomodulation KW - imaging KW - Differentiation KW - Stem cells KW - Alkaline phosphatase KW - Principal components analysis KW - Computed tomography KW - Regeneration KW - genomics KW - proteomics KW - Mesenchyme KW - Osteogenesis KW - W 30910:Imaging KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787994680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=High+Content+Imaging+of+Early+Morphological+Signatures+Predicts+Long+Term+Mineralization+Capacity+of+Human+Mesenchymal+Stem+Cells+upon+Osteogenic+Induction&rft.au=Marklein%2C+Ross+A%3BLo+Surdo%2C+Jessica+L%3BBellayr%2C+Ian+H%3BGodil%2C+Saniya+A%3BPuri%2C+Raj+K%3BBauer%2C+Steven+R&rft.aulast=Marklein&rft.aufirst=Ross&rft.date=2016-04-01&rft.volume=34&rft.issue=4&rft.spage=935&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/10.1002%2Fstem.2322 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Data processing; stromal cells; Paracrine signalling; Bone marrow; Image processing; Mineralization; imaging; Immunomodulation; Differentiation; Stem cells; Alkaline phosphatase; Principal components analysis; Regeneration; Computed tomography; proteomics; genomics; Mesenchyme; Osteogenesis DO - http://dx.doi.org/10.1002/stem.2322 ER - TY - JOUR T1 - Adverse outcome pathways: From research to regulation scientific workshop report. AN - 1786126249; 26774756 AB - An adverse outcome pathway (AOP) helps to organize existing knowledge on chemical mode of action, starting with a molecular initiating event such as receptor binding, continuing through key events, and ending with an adverse outcome such as reproductive impairment. AOPs can help identify knowledge gaps where more research is needed to understand the underlying mechanisms, aid in chemical hazard characterization, and guide the development of new testing approaches that use fewer or no animals. A September 2014 workshop in Bethesda, Maryland considered how the AOP concept could improve regulatory assessments of chemical toxicity. Scientists from 21 countries, representing industry, academia, regulatory agencies, and special interest groups, attended the workshop, titled Adverse Outcome Pathways: From Research to Regulation. Workshop plenary presentations were followed by breakout sessions that considered regulatory acceptance of AOPs and AOP-based tools, criteria for building confidence in an AOP for regulatory use, and requirements to build quantitative AOPs and AOP networks. Discussions during the closing session emphasized a need to increase transparent and inclusive collaboration, especially with disciplines outside of toxicology. Additionally, to increase impact, working groups should be established to systematically prioritize and develop AOPs. Multiple collaborative projects and follow-up activities resulted from the workshop. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Kleinstreuer, Nicole C AU - Sullivan, Kristie AU - Allen, David AU - Edwards, Stephen AU - Mendrick, Donna L AU - Embry, Michelle AU - Matheson, Joanna AU - Rowlands, J Craig AU - Munn, Sharon AU - Maull, Elizabeth AU - Casey, Warren AD - National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Electronic address: Nicole.kleinstreuer@nih.gov. ; Physicians Committee for Responsible Medicine, Washington, DC, USA. ; Integrated Laboratory Systems, Inc., Research Triangle Park, NC, USA. ; National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; ILSI Health and Environmental Sciences Institute, Washington, DC, USA. ; U.S. Consumer Product Safety Commission, Rockville, MD, USA. ; The Dow Chemical Company, Midland, MI, USA. ; Joint Research Centre, European Commission, Ispra, Italy. ; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 39 EP - 50 VL - 76 KW - Index Medicus KW - Quantitative KW - Acceptance KW - Computational KW - Application KW - AOP KW - Pathway KW - Criteria KW - Regulatory KW - Workshop KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1786126249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Adverse+outcome+pathways%3A+From+research+to+regulation+scientific+workshop+report.&rft.au=Kleinstreuer%2C+Nicole+C%3BSullivan%2C+Kristie%3BAllen%2C+David%3BEdwards%2C+Stephen%3BMendrick%2C+Donna+L%3BEmbry%2C+Michelle%3BMatheson%2C+Joanna%3BRowlands%2C+J+Craig%3BMunn%2C+Sharon%3BMaull%2C+Elizabeth%3BCasey%2C+Warren&rft.aulast=Kleinstreuer&rft.aufirst=Nicole&rft.date=2016-04-01&rft.volume=76&rft.issue=&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2016.01.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-05-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2016.01.007 ER - TY - JOUR T1 - Loperamide-induced expression of immune and inflammatory genes in Collies associated with ivermectin sensitivity. AN - 1785729340; 26471945 AB - This study evaluated the impact of the ABCB1-1Δ mutation in Collies which exhibited toxicity toward ivermectin, on changes in gene expression when given the unrelated ABCB1 substrate loperamide, to identify potential biomarkers predictive of drug safety. Thirty-two healthy intact Collies consisting of dogs with either a wild-type, heterozygous mutant, or homozygous mutant genotype were used. Whole blood samples were collected from Collies at 0 or 5 h following administration of loperamide at a dose of 0.10 mg/kg. Whole-genome gene expression microarray was conducted to examine for changes in gene expression. Microarray analysis identified loperamide-induced changes in gene expression which were specifically associated with ivermectin-sensitive phenotypes in Collies possessing the ABCB1-1Δ mutation. Gene pathway analysis further demonstrated that the altered genes are involved in immunological disease, cell death and survival, and cellular development. Thirteen genes, including CCL8 and IL-8, were identified. Collie dogs harboring ABCB1-1Δ mutation which also exhibited toxicity toward ivermectin demonstrated systematic responses following loperamide treatment exhibited by altered expression of genes involved in immune and inflammatory signaling pathways. Genes such as CCL8 and IL-8 are potential biomarkers in whole blood that may predict the safety of loperamide in dogs with ABCB1-1∆ mutation associated with ivermectin sensitivity. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of veterinary pharmacology and therapeutics AU - Zhu, M AU - Yancy, H F AU - Deaver, C AU - Jones, Y L AU - Myers, M J AD - U.S. Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Laurel, MD, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 131 EP - 137 VL - 39 IS - 2 KW - P-Glycoprotein KW - 0 KW - Loperamide KW - 6X9OC3H4II KW - Ivermectin KW - 70288-86-7 KW - Index Medicus KW - Animals KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Dogs KW - Mutation KW - Male KW - Female KW - Inflammation -- veterinary KW - Gene Expression Regulation -- immunology KW - Inflammation -- chemically induced KW - Dog Diseases -- genetics KW - Inflammation -- genetics KW - Dog Diseases -- chemically induced KW - Drug Hypersensitivity -- veterinary KW - Ivermectin -- adverse effects KW - Dog Diseases -- blood KW - Gene Expression Regulation -- drug effects KW - Inflammation -- metabolism KW - Dog Diseases -- metabolism KW - Loperamide -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785729340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+veterinary+pharmacology+and+therapeutics&rft.atitle=Loperamide-induced+expression+of+immune+and+inflammatory+genes+in+Collies+associated+with+ivermectin+sensitivity.&rft.au=Zhu%2C+M%3BYancy%2C+H+F%3BDeaver%2C+C%3BJones%2C+Y+L%3BMyers%2C+M+J&rft.aulast=Zhu&rft.aufirst=M&rft.date=2016-04-01&rft.volume=39&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Journal+of+veterinary+pharmacology+and+therapeutics&rft.issn=1365-2885&rft_id=info:doi/10.1111%2Fjvp.12268 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-14 N1 - Date created - 2016-03-02 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - XM850296; GENBANK; NM001005255; XM547914; XM533354; NM001003200; NM001003227; XM850260; NM001003359; NM001161710; XM858309; XM532793; XM005629542 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/jvp.12268 ER - TY - JOUR T1 - Production of Escherichia coli-based virus-like particle vaccine against porcine circovirus type 2 challenge in piglets: Structure characterization and protective efficacy validation AN - 1785254393; PQ0002920808 AB - We report the strategies leading to the large-production of soluble non-tag full-length porcine circovirus type 2 (PCV2) Cap protein in Escherichia coli. Under neutral pH condition, the purified recombinant Cap protein derived from E. coli expression self-assembles into homogenous round virus-like particle at the similar size of that of the intact PCV2 virus, which is further characterized by Cryo-EM single particle structure determined at 4.5Aa. The engineered PCV2 rCap VLP was tested as a subunit vaccine for the protective efficacy against PCV2 challenge on 3-week old piglets. Similar to commercial available PCV2 vaccine, the Cap VLP-immunized piglets developed specific antibody-mediated response and were protected from the virulent SH PCV2 strain challenge. Hence, the production of E. coli based PCV2Cap-VLP could be applied as a cost-friendly and effective subunit vaccine to control PCV2 spreading in developing countries. JF - Journal of Biotechnology AU - Xi, Xiangfeng AU - Mo, Xiaobing AU - Xiao, Yan AU - Yin, Bo AU - Lv, Chaochao AU - Wang, Yuzhou AU - Sun, Zhe AU - Yang, Qingyuan AU - Yao, Yali AU - Xuan, Yajie AU - Li, Xiangdong AU - Yuan, YAdam AU - Tian, Kegong AD - National Research Center for Veterinary Medicine, Road Cuiwei, High-Tech District, Luoyang 471003, PR China Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 8 EP - 12 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 223 SN - 0168-1656, 0168-1656 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Porcine circovirus type 2 KW - Escherichia coli expression KW - Virus-like particle KW - Cryo-EM structure KW - Vaccine efficacy KW - Virus-like particles KW - Spreading KW - Porcine circovirus KW - Escherichia coli KW - Catabolite activator protein KW - Vaccines KW - pH effects KW - Developing countries KW - J 02410:Animal Diseases KW - V 22410:Animal Diseases KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785254393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biotechnology&rft.atitle=Production+of+Escherichia+coli-based+virus-like+particle+vaccine+against+porcine+circovirus+type+2+challenge+in+piglets%3A+Structure+characterization+and+protective+efficacy+validation&rft.au=Xi%2C+Xiangfeng%3BMo%2C+Xiaobing%3BXiao%2C+Yan%3BYin%2C+Bo%3BLv%2C+Chaochao%3BWang%2C+Yuzhou%3BSun%2C+Zhe%3BYang%2C+Qingyuan%3BYao%2C+Yali%3BXuan%2C+Yajie%3BLi%2C+Xiangdong%3BYuan%2C+YAdam%3BTian%2C+Kegong&rft.aulast=Xi&rft.aufirst=Xiangfeng&rft.date=2016-04-01&rft.volume=223&rft.issue=&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biotechnology&rft.issn=01681656&rft_id=info:doi/10.1016%2Fj.jbiotec.2016.02.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Spreading; Virus-like particles; Catabolite activator protein; Vaccines; Developing countries; pH effects; Porcine circovirus; Escherichia coli DO - http://dx.doi.org/10.1016/j.jbiotec.2016.02.025 ER - TY - JOUR T1 - Alignment-independent technique for 3D QSAR analysis. AN - 1781542528; 27026022 AB - Molecular biochemistry is controlled by 3D phenomena but structure-activity models based on 3D descriptors are infrequently used for large data sets because of the computational overhead for determining molecular conformations. A diverse dataset of 146 androgen receptor binders was used to investigate how different methods for defining molecular conformations affect the performance of 3D-quantitative spectral data activity relationship models. Molecular conformations tested: (1) global minimum of molecules' potential energy surface; (2) alignment-to-templates using equal electronic and steric force field contributions; (3) alignment using contributions "Best-for-Each" template; (4) non-energy optimized, non-aligned (2D > 3D). Aggregate predictions from models were compared. Highest average coefficients of determination ranged from R Test (2) = 0.56 to 0.61. The best model using 2D > 3D (imported directly from ChemSpider) produced R Test (2) = 0.61. It was superior to energy-minimized and conformation-aligned models and was achieved in only 3-7 % of the time required using the other conformation strategies. Predictions averaged from models built on different conformations achieved a consensus R Test (2) = 0.65. The best 2D > 3D model was analyzed for underlying structure-activity relationships. For the compound strongest binding to the androgen receptor, 10 substructural features contributing to binding were flagged. Utility of 2D > 3D was compared for two other activity endpoints, each modeling a medium sized data set. Results suggested that large scale, accurate predictions using 2D > 3D SDAR descriptors may be produced for interactions involving endocrine system nuclear receptors and other data sets in which strongest activities are produced by fairly inflexible substrates. JF - Journal of computer-aided molecular design AU - Wilkes, Jon G AU - Stoyanova-Slavova, Iva B AU - Buzatu, Dan A AD - Division of Systems Biology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. jon.wilkes@fda.hhs.gov. ; Division of Systems Biology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 331 EP - 345 VL - 30 IS - 4 KW - Androgen Receptor Antagonists KW - 0 KW - Receptors, Androgen KW - Index Medicus KW - Quantitative structure–activity relationship KW - Spectral data-activity relationship KW - 3D modeling KW - Molecular conformation KW - Computer Simulation KW - Quantitative Structure-Activity Relationship KW - Humans KW - Protein Binding KW - Protein Conformation KW - Endocrine System -- pathology KW - Models, Molecular KW - Androgen Receptor Antagonists -- chemistry KW - Receptors, Androgen -- metabolism KW - Endocrine System -- drug effects KW - Receptors, Androgen -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1781542528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+computer-aided+molecular+design&rft.atitle=Alignment-independent+technique+for+3D+QSAR+analysis.&rft.au=Wilkes%2C+Jon+G%3BStoyanova-Slavova%2C+Iva+B%3BBuzatu%2C+Dan+A&rft.aulast=Wilkes&rft.aufirst=Jon&rft.date=2016-04-01&rft.volume=30&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+computer-aided+molecular+design&rft.issn=1573-4951&rft_id=info:doi/10.1007%2Fs10822-016-9909-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-28 N1 - Date created - 2016-04-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Chem Inf Model. 2012 Jul 23;52(7):1854-64 [22681591] SAR QSAR Environ Res. 2008 Apr-Jun;19(3-4):397-412 [18484504] PLoS Comput Biol. 2009 Dec;5(12):e1000594 [20011107] Curr Med Chem. 2011;18(6):923-30 [21182474] Horm Cancer. 2010 Oct;1(5):223-8 [21761368] PLoS One. 2011;6(8):e23144 [21829708] J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):74-82 [21515368] J Chem Inf Model. 2012 Oct 22;52(10):2570-8 [23030316] J Chem Inf Model. 2013 Jun 24;53(6):1406-14 [23705769] Environ Toxicol Chem. 2014 Jun;33(6):1271-82 [24464801] Bioorg Med Chem. 2014 Dec 1;22(23):6706-14 [25228124] J Comput Aided Mol Des. 2015 Feb;29(2):165-82 [25408244] Curr Opin Biotechnol. 2002 Feb;13(1):72-6 [11849962] Nat Rev Cancer. 2001 Oct;1(1):34-45 [11900250] SAR QSAR Environ Res. 2003 Oct-Dec;14(5-6):373-88 [14758981] J Med Chem. 1983 Apr;26(4):475-8 [6834380] J Comput Aided Mol Des. 1992 Dec;6(6):569-81 [1291626] Environ Health Perspect. 1993 Oct;101(5):378-84 [8080506] Chem Rev. 2005 Sep;105(9):3352-70 [16159155] J Chem Inf Model. 2009 Jul;49(7):1715-24 [19522467] J Chem Inf Model. 2014 Apr 28;54(4):1011-26 [24588678] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10822-016-9909-0 ER - TY - JOUR T1 - Maternal residential exposure to agricultural pesticides and birth defects in a 2003 to 2005 North Carolina birth cohort. AN - 1781536570; 26970546 AB - Birth defects are responsible for a large proportion of disability and infant mortality. Exposure to a variety of pesticides have been linked to increased risk of birth defects. We conducted a case-control study to estimate the associations between a residence-based metric of agricultural pesticide exposure and birth defects. We linked singleton live birth records for 2003 to 2005 from the North Carolina (NC) State Center for Health Statistics to data from the NC Birth Defects Monitoring Program. Included women had residence at delivery inside NC and infants with gestational ages from 20 to 44 weeks (n = 304,906). Pesticide exposure was assigned using a previously constructed metric, estimating total chemical exposure (pounds of active ingredient) based on crops within 500 meters of maternal residence, specific dates of pregnancy, and chemical application dates based on the planting/harvesting dates of each crop. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals for four categories of exposure (90(th) percentiles) compared with unexposed. Models were adjusted for maternal race, age at delivery, education, marital status, and smoking status. We observed elevated ORs for congenital heart defects and certain structural defects affecting the gastrointestinal, genitourinary and musculoskeletal systems (e.g., OR [95% confidence interval] [highest exposure vs. unexposed] for tracheal esophageal fistula/esophageal atresia = 1.98 [0.69, 5.66], and OR for atrial septal defects: 1.70 [1.34, 2.14]). Our results provide some evidence of associations between residential exposure to agricultural pesticides and several birth defects phenotypes. Birth Defects Research (Part A) 106:240-249, 2016. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Rappazzo, Kristen M AU - Warren, Joshua L AU - Meyer, Robert E AU - Herring, Amy H AU - Sanders, Alison P AU - Brownstein, Naomi C AU - Luben, Thomas J AD - Oak Ridge Institute for Science and Education at the U.S. Environmental Protection Agency, National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. ; Yale School of Public Health, Department of Biostatistics, New Haven, Connecticut. ; North Carolina Department of Health and Human Services, Raleigh, North Carolina. ; University of North Carolina Chapel Hill, Gillings School of Global Public Health, Department of Biostatistics, Chapel Hill, North Carolina. ; Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. ; Department of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, Tallahassee, Florida. ; National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 240 EP - 249 VL - 106 IS - 4 KW - Pesticides KW - 0 KW - Index Medicus KW - residential KW - birth defects KW - agriculture KW - pesticide exposure KW - GIS KW - congenital anomalies KW - Humans KW - Adult KW - Retrospective Studies KW - North Carolina -- epidemiology KW - Female KW - Pregnancy KW - Maternal Exposure -- adverse effects KW - Agriculture KW - Congenital Abnormalities -- epidemiology KW - Congenital Abnormalities -- etiology KW - Pesticides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1781536570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Maternal+residential+exposure+to+agricultural+pesticides+and+birth+defects+in+a+2003+to+2005+North+Carolina+birth+cohort.&rft.au=Rappazzo%2C+Kristen+M%3BWarren%2C+Joshua+L%3BMeyer%2C+Robert+E%3BHerring%2C+Amy+H%3BSanders%2C+Alison+P%3BBrownstein%2C+Naomi+C%3BLuben%2C+Thomas+J&rft.aulast=Rappazzo&rft.aufirst=Kristen&rft.date=2016-04-01&rft.volume=106&rft.issue=4&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23479 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-22 N1 - Date created - 2016-04-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Expo Sci Environ Epidemiol. 2012 Sep;22(5):429-38 [22617723] Public Health Rep. 2011 Mar-Apr;126(2):186-94 [21387948] Toxicol Appl Pharmacol. 2013 Apr 15;268(2):157-77 [23402800] Am J Med Genet A. 2013 May;161A(5):977-82 [23494929] Pediatrics. 2013 Nov;132(5):e1216-26 [24167181] Birth Defects Res A Clin Mol Teratol. 2013 Nov;97(11):709-25 [24265125] Int J Hyg Environ Health. 2014 Mar;217(2-3):248-54 [23871272] Am J Epidemiol. 2014 Mar 15;179(6):740-8 [24553680] Natl Vital Stat Rep. 2013 Dec 18;62(8):1-26 [24735562] Crit Rev Toxicol. 2014 May;44 Suppl 2:45-62 [24832553] Paediatr Perinat Epidemiol. 2014 Jul;28(4):338-44 [24697924] J Expo Sci Environ Epidemiol. 2014 Sep-Oct;24(5):497-503 [24149974] Birth Defects Res A Clin Mol Teratol. 2014 Sep;100(9):686-94 [24910073] Birth Defects Res A Clin Mol Teratol. 2014 Nov;100(11):887-94 [25196538] Environ Res. 2014 Nov;135:133-8 [25262086] Pediatrics. 2001 Sep;108(3):728-34 [11533343] Environ Health Perspect. 2002 Jun;110 Suppl 3:441-9 [12060842] Environ Health Perspect. 2003 Oct;111(13):1582-9 [14527836] Environ Health Perspect. 2003 Nov;111(14):1779-82 [14594631] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] Am J Public Health. 1996 May;86(5):731-4 [8629729] Arch Environ Health. 1992 May-Jun;47(3):236-8 [1596108] Epidemiology. 1997 Sep;8(5):537-44 [9270956] Epidemiology. 1999 Jan;10(1):60-6 [9888281] Environ Health. 2003 Oct 4;2(1):11 [14613490] Am J Epidemiol. 2006 Apr 15;163(8):743-53 [16495467] Environ Health Perspect. 2006 Oct;114(10):1589-95 [17035148] Acta Paediatr. 2009 Apr;98(4):664-9 [19183116] Sci Total Environ. 2009 Jul 15;407(15):4447-51 [19427676] Sci Total Environ. 2010 Jan 15;408(4):790-5 [19900697] Paediatr Perinat Epidemiol. 2010 Mar;24(2):200-8 [20415777] J Pediatr. 2013 Mar;162(3):581-6 [23036484] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23479 ER - TY - JOUR T1 - Standardized methods to generate mock (spiked) clinical specimens by spiking blood or plasma with cultured pathogens AN - 1780520964; PQ0002863394 AB - Aims To demonstrate standardized methods for spiking pathogens into human matrices for evaluation and comparison among diagnostic platforms. Methods and Results This study presents detailed methods for spiking bacteria or protozoan parasites into whole blood and virus into plasma. Proper methods must start with a documented, reproducible pathogen source followed by steps that include standardized culture, preparation of cryopreserved aliquots, quantification of the aliquots by molecular methods, production of sufficient numbers of individual specimens and testing of the platform with multiple mock specimens. Results are presented following the described procedures that showed acceptable reproducibility comparing in-house real-time PCR assays to a commercially available multiplex molecular assay. Conclusions A step by step procedure has been described that can be followed by assay developers who are targeting low prevalence pathogens. Significance and Impact of the Study The development of diagnostic platforms for detection of low prevalence pathogens such as biothreat or emerging agents is challenged by the lack of clinical specimens for performance evaluation. This deficit can be overcome using mock clinical specimens made by spiking cultured pathogens into human matrices. To facilitate evaluation and comparison among platforms, standardized methods must be followed in the preparation and application of spiked specimens. JF - Journal of Applied Microbiology AU - Dong, M AU - Fisher, C AU - Anez, G AU - Rios, M AU - Nakhasi, H L AU - Hobson, J P AU - Beanan, M AU - Hockman, D AU - Grigorenko, E AU - Duncan, R AD - Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 1119 EP - 1129 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 120 IS - 4 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Blood KW - Parasites KW - Polymerase chain reaction KW - Standards KW - Pathogens KW - Firing pattern KW - Cryopreservation KW - A 01300:Methods KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780520964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Standardized+methods+to+generate+mock+%28spiked%29+clinical+specimens+by+spiking+blood+or+plasma+with+cultured+pathogens&rft.au=Dong%2C+M%3BFisher%2C+C%3BAnez%2C+G%3BRios%2C+M%3BNakhasi%2C+H+L%3BHobson%2C+J+P%3BBeanan%2C+M%3BHockman%2C+D%3BGrigorenko%2C+E%3BDuncan%2C+R&rft.aulast=Dong&rft.aufirst=M&rft.date=2016-04-01&rft.volume=120&rft.issue=4&rft.spage=1119&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.13082 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Parasites; Blood; Polymerase chain reaction; Pathogens; Cryopreservation; Firing pattern; Standards DO - http://dx.doi.org/10.1111/jam.13082 ER - TY - JOUR T1 - Plasma pharmacokinetics of ceftiofur metabolite desfuroylceftiofur cysteine disulfide in holstein steers: application of nonlinear mixed-effects modeling AN - 1780505640; PQ0002834156 AB - Eight clinically normal and drug-naive Holstein steers were dosed with ceftiofur sodium at 2.2 mg/kg body weight intramuscularly. Doses were given at 24-h intervals for 5 days. Prior to the first dose and after all injections, blood samples were collected serially for determination of plasma concentrations of one of ceftiofur's main metabolites, desfuroylceftiofur cysteine disulfide (DCCD). A nonlinear mixed-effect model was used to analyze the plasma concentration data. A stochastic approximation expectation maximization (SAEM) algorithm in MONOLIX version 4.2.2 was used to approximate the likelihood of the nonlinear mixed-effect model and to estimate the population parameters. In addition, simulation studies were conducted to justify the model and demonstrate how to interpret the model parameters given different scenarios. JF - Journal of Veterinary Pharmacology and Therapeutics AU - Chiesa, O A AU - Feng, S AU - Kijak, P AU - Smith, E A AU - Li, H AU - Qiu, J AD - Office of Research, Division of Applied Veterinary Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 149 EP - 156 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 39 IS - 2 SN - 0140-7783, 0140-7783 KW - Toxicology Abstracts KW - Sodium KW - Data processing KW - Body weight KW - Cysteine KW - Algorithms KW - Metabolites KW - Stochasticity KW - Pharmacokinetics KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780505640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.atitle=Plasma+pharmacokinetics+of+ceftiofur+metabolite+desfuroylceftiofur+cysteine+disulfide+in+holstein+steers%3A+application+of+nonlinear+mixed-effects+modeling&rft.au=Chiesa%2C+O+A%3BFeng%2C+S%3BKijak%2C+P%3BSmith%2C+E+A%3BLi%2C+H%3BQiu%2C+J&rft.aulast=Chiesa&rft.aufirst=O&rft.date=2016-04-01&rft.volume=39&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.issn=01407783&rft_id=info:doi/10.1111%2Fjvp.12245 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Sodium; Data processing; Body weight; Cysteine; Algorithms; Metabolites; Stochasticity; Pharmacokinetics DO - http://dx.doi.org/10.1111/jvp.12245 ER - TY - JOUR T1 - Observational scores of dampness and mold associated with measurements of microbial agents and moisture in three public schools AN - 1780505137; PQ0002833083 AB - We examined associations between observational dampness scores and measurements of microbial agents and moisture in three public schools. A dampness score was created for each room from 4-point-scale scores (0-3) of water damage, water stains, visible mold, moldy odor, and wetness for each of 8 room components (ceiling, walls, windows, floor, ventilation, furniture, floor trench, and pipes), when present. We created mixed microbial exposure indices (MMEIs) for each of 121 rooms by summing decile ranks of 8 analytes (total culturable fungi; total, Gram-negative, and Gram-positive culturable bacteria; ergosterol; (1 arrow right 3)- beta -D-glucan; muramic acid; and endotoxin) in floor dust. We found significant (P less than or equal to 0.01) linear associations between the dampness score and culturable bacteria (total, Gram-positive, and Gram-negative) and the MMEIs. Rooms with dampness scores greater than 0.25 (median) had significantly (P < 0.05) higher levels of most microbial agents, MMEIs, and relative moisture content than those with lower scores ( less than or equal to 0.25). Rooms with reported recent water leaks had significantly (P < 0.05) higher dampness scores than those with historical or no reported water leaks. This study suggests that observational assessment of dampness and mold using a standardized form may be valuable for identifying and documenting water damage and associated microbial contamination. JF - Indoor Air AU - Cho, S J AU - Cox-Ganser, J M AU - Park, J-H AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 168 EP - 178 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 2 SN - 0905-6947, 0905-6947 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Endotoxins KW - Historical account KW - Pipes KW - Contamination KW - Ventilation KW - Fungi KW - Molds KW - Microbial contamination KW - Stains KW - Odors KW - Dust KW - Schools KW - Microorganisms KW - Odor KW - Standards KW - Indoor environments KW - Ergosterol KW - A 01490:Miscellaneous KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780505137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indoor+Air&rft.atitle=Observational+scores+of+dampness+and+mold+associated+with+measurements+of+microbial+agents+and+moisture+in+three+public+schools&rft.au=Cho%2C+S+J%3BCox-Ganser%2C+J+M%3BPark%2C+J-H&rft.aulast=Cho&rft.aufirst=S&rft.date=2016-04-01&rft.volume=26&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Indoor+Air&rft.issn=09056947&rft_id=info:doi/10.1111%2Fina.12191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Endotoxins; Ventilation; Contamination; Fungi; Microorganisms; Odor; Molds; Stains; Ergosterol; Dust; Pipes; Historical account; Schools; Standards; Microbial contamination; Indoor environments; Odors DO - http://dx.doi.org/10.1111/ina.12191 ER - TY - JOUR T1 - Bisphenol A, Bisphenol S, and 4-Hydro​xyphenyl 4-Isopro​oxyphenyl​sulfone (BPSIP) in Urine and Blood of Cashiers. AN - 1777980946; 26309242 AB - Bisphenol A (BPA) is a high-production-volume chemical associated with a wide range of health outcomes in animal and human studies. BPA is used as a developer in thermal paper products, including cash register receipt paper; however, little is known about exposure of cashiers to BPA and alternative compounds in receipt paper. We determined whether handling receipt paper results in measurable absorption of BPA or the BPA alternatives bisphenol S (BPS) and 4-hydroxyphenyl 4-isoprooxyphenylsulfone (BPSIP). Cashiers (n = 77) and non-cashiers (n = 25) were recruited from the Raleigh-Durham-Chapel Hill region of North Carolina during 2011-2013. Receipts were analyzed for the presence of BPA or alternatives considered for use in thermal paper. In cashiers, total urine and serum BPA, BPS, and BPSIP levels in post-shift samples (collected ≤ 2 hr after completing a shift) were compared with pre-shift samples. Levels of these compounds in urine from cashiers were compared to levels in urine from non-cashiers. Each receipt contained 1-2% by weight of the paper of BPA, BPS, or BPSIP. The post-shift geometric mean total urinary BPS concentration was significantly higher than the pre-shift mean in 33 cashiers who handled receipts containing BPS. The mean urine BPA concentrations in 31 cashiers who handled BPA receipts were as likely to decrease as to increase after a shift, but the mean post-shift concentrations were significantly higher than those in non-cashiers. BPSIP was detected more frequently in the urine of cashiers handling BPSIP receipts than in the urine of non-cashiers. Only a few cashiers had detectable levels of total BPA or BPS in serum, whereas BPSIP tended to be detected more frequently. Thermal receipt paper is a potential source of occupational exposure to BPA, BPS, and BPSIP. Thayer KA, Taylor KW, Garantziotis S, Schurman SH, Kissling GE, Hunt D, Herbert B, Church R, Jankowich R, Churchwell MI, Scheri RC, Birnbaum LS, Bucher JR. 2016. Bisphenol A, bisphenol S, and 4-hydro​xyphenyl 4-isopro​oxyphenyl​sulfone (BPSIP) in urine and blood of cashiers. Environ Health Perspect 124:437-444; http://dx.doi.org/10.1289/ehp.1409427. JF - Environmental health perspectives AU - Thayer, Kristina A AU - Taylor, Kyla W AU - Garantziotis, Stavros AU - Schurman, Shepherd H AU - Kissling, Grace E AU - Hunt, Dawn AU - Herbert, Brenda AU - Church, Rebecca AU - Jankowich, Rachael AU - Churchwell, Mona I AU - Scheri, Richard C AU - Birnbaum, Linda S AU - Bucher, John R AD - Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 437 EP - 444 VL - 124 IS - 4 KW - 4-hydroxyphenyl 4-isopropoxyphenylsulfone KW - 0 KW - Benzhydryl Compounds KW - Phenols KW - Sulfones KW - bis(4-hydroxyphenyl)sulfone KW - 80-09-1 KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Humans KW - North Carolina KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Sulfones -- blood KW - Paper KW - Phenols -- blood KW - Sulfones -- urine KW - Benzhydryl Compounds -- blood KW - Phenols -- urine KW - Occupational Exposure -- analysis KW - Benzhydryl Compounds -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777980946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Bisphenol+A%2C+Bisphenol+S%2C+and+4-Hydro%E2%80%8Bxyphenyl+4-Isopro%E2%80%8Boxyphenyl%E2%80%8Bsulfone+%28BPSIP%29+in+Urine+and+Blood+of+Cashiers.&rft.au=Thayer%2C+Kristina+A%3BTaylor%2C+Kyla+W%3BGarantziotis%2C+Stavros%3BSchurman%2C+Shepherd+H%3BKissling%2C+Grace+E%3BHunt%2C+Dawn%3BHerbert%2C+Brenda%3BChurch%2C+Rebecca%3BJankowich%2C+Rachael%3BChurchwell%2C+Mona+I%3BScheri%2C+Richard+C%3BBirnbaum%2C+Linda+S%3BBucher%2C+John+R&rft.aulast=Thayer&rft.aufirst=Kristina&rft.date=2016-04-01&rft.volume=124&rft.issue=4&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1409427 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-24 N1 - Date created - 2016-04-02 N1 - Date revised - 2017-01-26 N1 - SuppNotes - Cited By: Environ Sci Technol. 2011 Nov 1;45(21):9372-9 [21939283] PLoS One. 2014;9(10):e110509 [25337790] Environ Sci Technol. 2012 Jun 19;46(12):6860-6 [22620267] Environ Sci Technol. 2012 Aug 21;46(16):9138-45 [22784190] Toxicol Lett. 2012 Sep 18;213(3):305-8 [22796587] Sci Total Environ. 2012 Oct 1;435-436:30-3 [22846760] Environ Sci Technol. 2012 Nov 6;46(21):11558-65 [23020513] Environ Health Perspect. 2013 Mar;121(3):283-6 [23458838] J Agric Food Chem. 2013 May 15;61(19):4655-62 [23614805] Chemosphere. 2013 Aug;92(9):1190-4 [23484460] Environ Res. 2013 Oct;126:211-4 [23899777] Food Chem Toxicol. 2013 Dec;62:949-63 [23959105] JAMA. 2014 Feb 26;311(8):859-60 [24570250] Breast Cancer Res. 2013;15(5):403 [24083327] J Toxicol Environ Health A. 2008;71(8):471-3 [18338280] NTP CERHR MON. 2008 Sep;(22):v, vii-ix, 1-64 passim [19407859] Reprod Toxicol. 2010 Aug;30(1):131-7 [20214975] Anal Bioanal Chem. 2010 Sep;398(1):571-6 [20623271] Toxicol Appl Pharmacol. 2010 Oct 1;248(1):1-11 [20655935] Rapid Commun Mass Spectrom. 2010 Oct 30;24(20):3011-20 [20872634] Environ Health Perspect. 2011 Jan;119(1):131-7 [21205581] Arch Toxicol. 2011 Sep;85(9):1035-43 [21287149] Toxicol Sci. 2011 Sep;123(1):48-57 [21705716] Toxicol Sci. 2014 May;139(1):4-20 [24496641] Arch Environ Contam Toxicol. 2014 Jul;67(1):50-9 [24639116] Toxicol Lett. 2014 Nov 4;230(3):413-20 [25175590] Environ Sci Technol. 2012 Jun 19;46(12):6515-22 [22591511] N1 - Last updated - 2017-01-26 DO - http://dx.doi.org/10.1289/ehp.1409427 ER - TY - JOUR T1 - Applying network analysis and Nebula (neighbor-edges based and unbiased leverage algorithm) to ToxCast data. AN - 1777980693; 26826365 AB - ToxCast data have been used to develop models for predicting in vivo toxicity. To predict the in vivo toxicity of a new chemical using a ToxCast data based model, its ToxCast bioactivity data are needed but not normally available. The capability of predicting ToxCast bioactivity data is necessary to fully utilize ToxCast data in the risk assessment of chemicals. We aimed to understand and elucidate the relationships between the chemicals and bioactivity data of the assays in ToxCast and to develop a network analysis based method for predicting ToxCast bioactivity data. We conducted modularity analysis on a quantitative network constructed from ToxCast data to explore the relationships between the assays and chemicals. We further developed Nebula (neighbor-edges based and unbiased leverage algorithm) for predicting ToxCast bioactivity data. Modularity analysis on the network constructed from ToxCast data yielded seven modules. Assays and chemicals in the seven modules were distinct. Leave-one-out cross-validation yielded a Q(2) of 0.5416, indicating ToxCast bioactivity data can be predicted by Nebula. Prediction domain analysis showed some types of ToxCast assay data could be more reliably predicted by Nebula than others. Network analysis is a promising approach to understand ToxCast data. Nebula is an effective algorithm for predicting ToxCast bioactivity data, helping fully utilize ToxCast data in the risk assessment of chemicals. Published by Elsevier Ltd. JF - Environment international AU - Ye, Hao AU - Luo, Heng AU - Ng, Hui Wen AU - Meehan, Joe AU - Ge, Weigong AU - Tong, Weida AU - Hong, Huixiao AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: huixiao.hong@fda.hhs.gov. PY - 2016 SP - 81 EP - 92 VL - 89-90 KW - Index Medicus KW - Nebula KW - Environmental toxicity KW - Network algorithm KW - ToxCast KW - Humans KW - Toxicity Tests KW - Biological Assay KW - Algorithms KW - Ecotoxicology -- methods KW - Risk Assessment KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777980693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Applying+network+analysis+and+Nebula+%28neighbor-edges+based+and+unbiased+leverage+algorithm%29+to+ToxCast+data.&rft.au=Ye%2C+Hao%3BLuo%2C+Heng%3BNg%2C+Hui+Wen%3BMeehan%2C+Joe%3BGe%2C+Weigong%3BTong%2C+Weida%3BHong%2C+Huixiao&rft.aulast=Ye&rft.aufirst=Hao&rft.date=2016-04-01&rft.volume=89-90&rft.issue=&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2016.01.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-14 N1 - Date created - 2016-04-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2016.01.010 ER - TY - GEN T1 - Marking a New Understanding of Climate and Health. AN - 1777979958; 27035485 JF - Environmental health perspectives AU - Birnbaum, Linda S AU - Balbus, John M AU - Tart, Kimberly Thigpen Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 1 VL - 124 IS - 4 KW - Index Medicus KW - United States KW - Public Health KW - Humans KW - Environmental Health KW - Climate Change UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777979958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Environmental+health+perspectives&rft.atitle=Marking+a+New+Understanding+of+Climate+and+Health.&rft.au=Birnbaum%2C+Linda+S%3BBalbus%2C+John+M%3BTart%2C+Kimberly+Thigpen&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2016-04-01&rft.volume=124&rft.issue=4&rft.spage=A59&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1611410 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-24 N1 - Date created - 2016-04-02 N1 - Date revised - 2017-01-26 N1 - SuppNotes - Erratum In: Environ Health Perspect. 2016 Jun 1;124(6):A105 [27248290] N1 - Last updated - 2017-01-26 DO - http://dx.doi.org/10.1289/ehp.1611410 ER - TY - JOUR T1 - Informing 21st-Century Risk Assessments with 21st-Century Science. AN - 1777979389; 27035154 AB - Understanding and preventing adverse impacts from chemicals in the environment is fundamental to protecting public health, and chemical risk assessments are used to inform public health decisions in the United States and around the world. Traditional chemical risk assessments focus on health effects of environmental contaminants on a chemical-by-chemical basis, largely based on data from animal models using exposures that are typically higher than those experienced by humans. Results from environmental epidemiology studies sometimes show effects that are not observed in animal studies at human exposure levels that are lower than those used in animal studies. In addition, new approaches such as Toxicology in the 21st Century (Tox21) and exposure forecasting (ExpoCast) are generating mechanistic data that provide broad coverage of chemical space, chemical mixtures, and potential associated health outcomes, along with improved exposure estimates. It is becoming clear that risk assessments in the future will need to use the full range of available mechanistic, animal, and human data to integrate multiple types of data and to consider nontraditional health outcomes and end points. This perspective was developed at the "Strengthening the Scientific Basis of Chemical Safety Assessments" workshop, which was cosponsored by the U.S. Environmental Protection Agency and the National Institute of Environmental Health Sciences, where gaps between the emerging science and traditional chemical risk assessments were explored, and approaches for bridging the gaps were considered. JF - Environmental health perspectives AU - Birnbaum, Linda S AU - Burke, Thomas A AU - Jones, James J AD - Office of the Director, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - A60 EP - A63 VL - 124 IS - 4 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - United States KW - Animals KW - United States Environmental Protection Agency KW - Environmental Health KW - Humans KW - Computational Biology -- methods KW - Forecasting KW - Environmental Exposure -- adverse effects KW - National Institute of Environmental Health Sciences (U.S.) KW - Environmental Pollutants -- toxicity KW - Toxicology -- methods KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777979389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Informing+21st-Century+Risk+Assessments+with+21st-Century+Science.&rft.au=Birnbaum%2C+Linda+S%3BBurke%2C+Thomas+A%3BJones%2C+James+J&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2016-04-01&rft.volume=124&rft.issue=4&rft.spage=A60&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1511135 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-24 N1 - Date created - 2016-04-02 N1 - Date revised - 2017-01-26 N1 - SuppNotes - Cited By: Environ Health Perspect. 2015 May;123(5):458-66 [25622337] Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4901-10 [26283345] N1 - Last updated - 2017-01-26 DO - http://dx.doi.org/10.1289/ehp.1511135 ER - TY - JOUR T1 - Effects of developmental exposure to bisphenol A on spatial navigational learning and memory in rats: A CLARITY-BPA study. AN - 1777979059; 26436835 AB - Bisphenol A (BPA) is a ubiquitous industrial chemical used in the production of a wide variety of items. Previous studies suggest BPA exposure may result in neuro-disruptive effects; however, data are inconsistent across animal and human studies. As part of the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA), we sought to determine whether female and male rats developmentally exposed to BPA demonstrated later spatial navigational learning and memory deficits. Pregnant NCTR Sprague-Dawley rats were orally dosed from gestational day 6 to parturition, and offspring were directly orally dosed until weaning (postnatal day 21). Treatment groups included a vehicle control, three BPA doses (2.5μg/kg body weight (bw)/day-[2.5], 25μg/kg bw/day-[25], and 2500μg/kg bw/day-[2500]) and a 0.5μg/kg/day ethinyl estradiol (EE)-reference estrogen dose. At adulthood, 1/sex/litter was tested for seven days in the Barnes maze. The 2500 BPA group sniffed more incorrect holes on day 7 than those in the control, 2.5 BPA, and EE groups. The 2500 BPA females were less likely than control females to locate the escape box in the allotted time (p value=0.04). Although 2.5 BPA females exhibited a prolonged latency, the effect did not reach significance (p value=0.06), whereas 2.5 BPA males showed improved latency compared to control males (p value=0.04), although the significance of this result is uncertain. No differences in serum testosterone concentration were detected in any male or female treatment groups. Current findings suggest developmental exposure of rats to BPA may disrupt aspects of spatial navigational learning and memory. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Hormones and behavior AU - Johnson, Sarah A AU - Javurek, Angela B AU - Painter, Michele S AU - Ellersieck, Mark R AU - Welsh, Thomas H AU - Camacho, Luísa AU - Lewis, Sherry M AU - Vanlandingham, Michelle M AU - Ferguson, Sherry A AU - Rosenfeld, Cheryl S AD - Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States; Biomedical Sciences, University of Missouri, Columbia, MO 65211, United States. ; Agriculture Experimental Station-Statistics, University of Missouri, Columbia, MO 65211, United States. ; Department of Animal Science, Texas A&M University, College Station, TX 77843, United States. ; Division of Biochemical Toxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, United States. ; Office of Scientific Coordination, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, United States. ; Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, United States. ; Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, United States; Biomedical Sciences, University of Missouri, Columbia, MO 65211, United States; Genetics Area Program, University of Missouri, Columbia, MO 65211, United States; Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, MO 65211, United States. Electronic address: rosenfeldc@missouri.edu. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 139 EP - 148 VL - 80 KW - Benzhydryl Compounds KW - 0 KW - Estrogens, Non-Steroidal KW - Phenols KW - Ethinyl Estradiol KW - 423D2T571U KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Behavioral testing KW - Testosterone KW - Estrogens KW - Endocrine disrupting chemicals KW - DOHaD KW - Barnes maze KW - Rodents KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Maze Learning -- drug effects KW - Spatial Navigation KW - Dose-Response Relationship, Drug KW - Humans KW - Male KW - Female KW - Pregnancy KW - Ethinyl Estradiol -- pharmacology KW - Benzhydryl Compounds -- toxicity KW - Spatial Learning -- drug effects KW - Estrogens, Non-Steroidal -- toxicity KW - Phenols -- toxicity KW - Spatial Memory -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777979059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hormones+and+behavior&rft.atitle=Effects+of+developmental+exposure+to+bisphenol+A+on+spatial+navigational+learning+and+memory+in+rats%3A+A+CLARITY-BPA+study.&rft.au=Johnson%2C+Sarah+A%3BJavurek%2C+Angela+B%3BPainter%2C+Michele+S%3BEllersieck%2C+Mark+R%3BWelsh%2C+Thomas+H%3BCamacho%2C+Lu%C3%ADsa%3BLewis%2C+Sherry+M%3BVanlandingham%2C+Michelle+M%3BFerguson%2C+Sherry+A%3BRosenfeld%2C+Cheryl+S&rft.aulast=Johnson&rft.aufirst=Sarah&rft.date=2016-04-01&rft.volume=80&rft.issue=&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Hormones+and+behavior&rft.issn=1095-6867&rft_id=info:doi/10.1016%2Fj.yhbeh.2015.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-04-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Pathol. 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Feb;93(1):74-104 [221551] J Neurosci Methods. 1984 May;11(1):47-60 [6471907] Horm Behav. 1985 Dec;19(4):469-98 [3910535] Behav Neurosci. 1990 Feb;104(1):84-97 [2317288] J Comp Psychol. 1990 Mar;104(1):88-93 [2191835] Brain Res. 1992 Feb 14;572(1-2):310-3 [1611529] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yhbeh.2015.09.005 ER - TY - JOUR T1 - Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Ribavirin. AN - 1777077204; 26952879 AB - Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release solid oral dosage forms containing ribavirin are reviewed. Ribavirin is highly soluble, but its permeability characteristics are not well defined. Therefore according to the Biopharmaceutical Classification System, and taking a "worst case" approach, ribavirin should be assigned to class III. As ribavirin is transported across the brush border membrane of the human jejunum by hCNT2, it shows saturable uptake in the intestine. However, no common excipients have been shown to compete for ribavirin absorption, nor have problems with BE of immediate release ribavirin formulations containing different excipients and produced by different manufacturing methods been reported in the open literature. So the risk of bioinequivalence caused by these factors appears to be low. Ribavirin is considered a narrow therapeutic index drug, as judged by comparing the minimum effective concentration and minimum toxic concentrations in blood. Although ribavirin would not be eligible for approval via a Biopharmaceutical Classification System-based biowaiver procedure according to today's guidances due to its narrow therapeutic index, the risks of biowaiving should be weighed against the considerable risks associated with studying BE of ribavirin products in healthy subjects. Copyright © 2016 American Pharmacists Association®. All rights reserved. JF - Journal of pharmaceutical sciences AU - Goodarzi, Navid AU - Barazesh Morgani, Ahmadreza AU - Abrahamsson, Bertil AU - Cristofoletti, Rodrigo AU - Groot, D W AU - Langguth, Peter AU - Mehta, Mehul U AU - Polli, James E AU - Shah, Vinod P AU - Dressman, Jennifer B AD - Nanotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. ; Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. ; Pharmaceutical Development, AstraZeneca R&D, Mölndal, Sweden. ; Brazilian Health Surveillance Agency (Anvisa), Division of Therapeutic Equivalence, Brasilia, Brazil. ; RIVM - National Institute for Public Health and the Environment, Bilthoven, Utrecht, The Netherlands. ; Institute of Pharmacy, Johannes Gutenberg University, Mainz, Germany. ; Food and Drug Administration, Center for Drug Evaluation, Silver Spring, Maryland 20993. ; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland 21201. ; International Pharmaceutical Federation FIP, The Hague, The Netherlands. ; Institute of Pharmaceutical Technology, Goethe University, Frankfurt am Main, Germany. Electronic address: dressman@em.uni-frankfurt.de. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 1362 EP - 1369 VL - 105 IS - 4 KW - Antiviral Agents KW - 0 KW - Capsules KW - Excipients KW - Tablets KW - Ribavirin KW - 49717AWG6K KW - Index Medicus KW - BCS KW - absorption KW - biowaiver KW - ribavirin KW - solubility KW - permeability KW - Therapeutic Equivalency KW - Administration, Oral KW - Permeability KW - Solubility KW - Drug Compounding KW - Humans KW - Excipients -- chemistry KW - Antiviral Agents -- administration & dosage KW - Ribavirin -- pharmacokinetics KW - Antiviral Agents -- pharmacokinetics KW - Antiviral Agents -- chemistry KW - Ribavirin -- chemistry KW - Ribavirin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777077204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Biowaiver+Monographs+for+Immediate+Release+Solid+Oral+Dosage+Forms%3A+Ribavirin.&rft.au=Goodarzi%2C+Navid%3BBarazesh+Morgani%2C+Ahmadreza%3BAbrahamsson%2C+Bertil%3BCristofoletti%2C+Rodrigo%3BGroot%2C+D+W%3BLangguth%2C+Peter%3BMehta%2C+Mehul+U%3BPolli%2C+James+E%3BShah%2C+Vinod+P%3BDressman%2C+Jennifer+B&rft.aulast=Goodarzi&rft.aufirst=Navid&rft.date=2016-04-01&rft.volume=105&rft.issue=4&rft.spage=1362&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=1520-6017&rft_id=info:doi/10.1016%2Fj.xphs.2016.01.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.xphs.2016.01.017 ER - TY - JOUR T1 - MMP-9-Dependent Serum-Borne Bioactivity Caused by Multiwalled Carbon Nanotube Exposure Induces Vascular Dysfunction via the CD36 Scavenger Receptor. AN - 1777075771; 26801584 AB - Inhalation of multiwalled carbon nanotubes (MWCNT) causes systemic effects including vascular inflammation, endothelial dysfunction, and acute phase protein expression. MWCNTs translocate only minimally beyond the lungs, thus cardiovascular effects thereof may be caused by generation of secondary biomolecular factors from MWCNT-pulmonary interactions that spill over into the systemic circulation. Therefore, we hypothesized that induced matrix metalloproteinase-9 (MMP-9) is a generator of factors that, in turn, drive vascular effects through ligand-receptor interactions with the multiligand pattern recognition receptor, CD36. To test this, wildtype (WT; C57BL/6) and MMP-9(-/-)mice were exposed to varying doses (10 or 40 µg) of MWCNTs via oropharyngeal aspiration and serum was collected at 4 and 24 h postexposure. Endothelial cells treated with serum from MWCNT-exposed WT mice exhibited significantly reduced nitric oxide (NO) generation, as measured by electron paramagnetic resonance, an effect that was independent of NO scavenging. Serum from MWCNT-exposed WT mice inhibited acetylcholine (ACh)-mediated relaxation of aortic rings at both time points. Absence of CD36 on the aortic rings (obtained from CD36-deficient mice) abolished the serum-induced impairment of vasorelaxation. MWCNT exposure induced MMP-9 protein levels in both bronchoalveolar lavage and whole lung lysates. Serum from MMP-9(-/-)mice exposed to MWCNT did not diminish the magnitude of vasorelaxation in naïve WT aortic rings, although a modest right shift of the ACh dose-response curve was observed in both MWCNT dose groups relative to controls. In conclusion, pulmonary exposure to MWCNT leads to elevated MMP-9 levels and MMP-9-dependent generation of circulating bioactive factors that promote endothelial dysfunction and decreased NO bioavailability via interaction with vascular CD36. © The Author 2016. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Aragon, Mario AU - Erdely, Aaron AU - Bishop, Lindsey AU - Salmen, Rebecca AU - Weaver, John AU - Liu, Jim AU - Hall, Pamela AU - Eye, Tracy AU - Kodali, Vamsi AU - Zeidler-Erdely, Patti AU - Stafflinger, Jillian E AU - Ottens, Andrew K AU - Campen, Matthew J AD - *Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, New Mexico 87131. ; National Institute for Occupational Safety and Health, Morgantown, West Virginia 26508; ; Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298. ; *Department of Pharmaceutical Sciences, University of New Mexico College of Pharmacy, Albuquerque, New Mexico 87131 mcampen@unm.edu. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 488 EP - 498 VL - 150 IS - 2 KW - Antigens, CD36 KW - 0 KW - Nanotubes, Carbon KW - Nitric Oxide KW - 31C4KY9ESH KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Mmp9 protein, mouse KW - Index Medicus KW - CD36 KW - vascular KW - toxicity KW - carbon nanoparticle KW - MMP-9. KW - cardiovascular KW - serum KW - Lung -- immunology KW - Animals KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Inhalation Exposure KW - Nitric Oxide -- blood KW - Mice, Inbred C57BL KW - Lung -- drug effects KW - Cell Culture Techniques KW - Vasodilation -- drug effects KW - Lung -- metabolism KW - Mice, Knockout KW - Endothelial Cells -- drug effects KW - Antigens, CD36 -- metabolism KW - Matrix Metalloproteinase 9 -- metabolism KW - Endothelium, Vascular -- drug effects KW - Serum -- immunology KW - Serum -- chemistry KW - Matrix Metalloproteinase 9 -- genetics KW - Endothelium, Vascular -- physiopathology KW - Nanotubes, Carbon -- toxicity KW - Endothelium, Vascular -- immunology KW - Endothelial Cells -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777075771?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=MMP-9-Dependent+Serum-Borne+Bioactivity+Caused+by+Multiwalled+Carbon+Nanotube+Exposure+Induces+Vascular+Dysfunction+via+the+CD36+Scavenger+Receptor.&rft.au=Aragon%2C+Mario%3BErdely%2C+Aaron%3BBishop%2C+Lindsey%3BSalmen%2C+Rebecca%3BWeaver%2C+John%3BLiu%2C+Jim%3BHall%2C+Pamela%3BEye%2C+Tracy%3BKodali%2C+Vamsi%3BZeidler-Erdely%2C+Patti%3BStafflinger%2C+Jillian+E%3BOttens%2C+Andrew+K%3BCampen%2C+Matthew+J&rft.aulast=Aragon&rft.aufirst=Mario&rft.date=2016-04-01&rft.volume=150&rft.issue=2&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-27 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw015 ER - TY - JOUR T1 - Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent. AN - 1777075593; 26801583 AB - Silver nanoparticles (AgNPs) are incorporated into medical and consumer products to exploit their excellent antimicrobial properties; however, potential mechanisms of toxicity of AgNPs in mammalian cells are not fully understood. The objective of this study was to determine the mechanism of size- and concentration-dependent cytotoxicity of AgNPs in human liver-derived hepatoma (HepG2) cells. Mechanisms of toxicity were explored at subcytotoxic concentrations (≤10 µg/ml AgNPs) and autophagy induction, lysosomal activity, inflammasome-dependent caspase-1 activation, and apoptosis were examined. Using enhanced dark-field light microscopy, hyperspectral imaging, electron microscopy, and energy dispersive X-ray spectroscopy, AgNPs were shown to rapidly accumulate in cytoplasmic vesicles for up to 24 h and 10-nm AgNPs exhibited the highest uptake and accumulation. Autophagy and enhanced lysosomal activity were induced at noncytotoxic concentrations (1 µg/ml; primary particle size:10 > 50 >100 nm), whereas increased caspase-3 activity (associated with apoptosis) was observed at cytotoxic concentrations (10, 25, and 50 µg/ml). Subcytotoxic concentrations of AgNPs enhanced expression of LC3B, a pro-autophagic protein, and CHOP, an apoptosis inducing ER-stress protein, and activation of NLRP3-inflammasome (caspase-1, IL-1β). Disrupting the autophagy-lysosomal pathway through chloroquine or ATG5-siRNA exacerbated AgNPs-induced caspase-1 activation and lactate dehydrogenase release, suggesting that NLRP3-inflammasome plays an important role in AgNPs-induced cytotoxicity. Overall, 10-nm AgNPs showed the highest cellular responses compared with 50- and 100-nm AgNPs based on equal mass dosimetry. The results indicate the potential of vesicle-engulfed 10-nm AgNPs to induce cytotoxicity by a mechanism involving perturbations in the autophagy-lysosomal system and inflammasome activation. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Mishra, Anurag R AU - Zheng, Jiwen AU - Tang, Xing AU - Goering, Peter L AD - Division of Biology, Chemistry, and Materials Science, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, USA. ; Division of Biology, Chemistry, and Materials Science, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, USA Peter.Goering@fda.hhs.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 473 EP - 487 VL - 150 IS - 2 KW - Inflammasomes KW - 0 KW - NLR Family, Pyrin Domain-Containing 3 Protein KW - NLRP3 protein, human KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - inflammasome KW - apoptosis KW - silver nanoparticle KW - nanomaterials KW - autophagy KW - caspase-1. KW - Microscopy, Fluorescence KW - Microscopy, Confocal KW - Microscopy, Electron, Transmission KW - Hep G2 Cells KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Particle Size KW - Humans KW - Apoptosis -- drug effects KW - Cell Culture Techniques KW - Flow Cytometry KW - Silver -- chemistry KW - Autophagy -- drug effects KW - Metal Nanoparticles -- toxicity KW - Metal Nanoparticles -- chemistry KW - Silver -- toxicity KW - Lysosomes -- ultrastructure KW - NLR Family, Pyrin Domain-Containing 3 Protein -- metabolism KW - Lysosomes -- drug effects KW - Inflammasomes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777075593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Silver+Nanoparticle-Induced+Autophagic-Lysosomal+Disruption+and+NLRP3-Inflammasome+Activation+in+HepG2+Cells+Is+Size-Dependent.&rft.au=Mishra%2C+Anurag+R%3BZheng%2C+Jiwen%3BTang%2C+Xing%3BGoering%2C+Peter+L&rft.aulast=Mishra&rft.aufirst=Anurag&rft.date=2016-04-01&rft.volume=150&rft.issue=2&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-27 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw011 ER - TY - JOUR T1 - Toxicological Assessment of CoO and La2O3 Metal Oxide Nanoparticles in Human Small Airway Epithelial Cells. AN - 1777075183; 26769336 AB - Cobalt monoxide (CoO) and lanthanum oxide (La2O3) nanoparticles are 2 metal oxide nanoparticles with different redox potentials according to their semiconductor properties. By utilizing these two nanoparticles, this study sought to determine how metal oxide nanoparticle's mode of toxicological action is related to their physio-chemical properties in human small airway epithelial cells (SAEC). We investigated cellular toxicity, production of superoxide radicals and alterations in gene expression related to oxidative stress, and cellular death at 6 and 24 h following exposure to CoO and La2O3(administered doses: 0, 5, 25, and 50 µg/ml) nanoparticles. CoO nanoparticles induced gene expression related to oxidative stress at 6 h. After characterizing the nanoparticles, transmission electron microscope analysis showed SAEC engulfed CoO and La2O3nanoparticles. CoO nanoparticles were toxic after 6 and 24 h of exposure to 25.0 and 50.0 µg/ml administered doses, whereas, La2O3nanoparticles were toxic only after 24 h using the same administered doses. Based upon the Volumetric Centrifugation Methodin vivoSedimentation, Diffusion, and Dosimetry, the dose of CoO and La2O3nanoparticles delivered at 6 and 24 h were determined to be: CoO: 1.25, 6.25, and 12.5 µg/ml; La2O3: 5, 25, and 50 µg/ml and CoO: 4, 20, and 40 µg/ml; and La2O3: 5, 25, 50 µg/ml, respectively. CoO nanoparticles produced more superoxide radicals and caused greater stimulation of total tyrosine and threonine phosphorylation at both 6 and 24 h when compared with La2O3nanoparticles. Taken together, these data provide evidence that different toxicological modes of action were involved in CoO and La2O3metal oxide nanoparticle-induced cellular toxicity. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Sisler, Jennifer D AU - Pirela, Sandra V AU - Shaffer, Justine AU - Mihalchik, Amy L AU - Chisholm, William P AU - Andrew, Michael E AU - Schwegler-Berry, Diane AU - Castranova, Vincent AU - Demokritou, Philip AU - Qian, Yong AD - *Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; yaq2@cdc.gov. ; *Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; ; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26505. ; T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts 02115; and. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 418 EP - 428 VL - 150 IS - 2 KW - Oxides KW - 0 KW - Reactive Oxygen Species KW - Cobalt KW - 3G0H8C9362 KW - lanthanum oxide KW - 4QI5EL790W KW - Lanthanum KW - 6I3K30563S KW - cobalt oxide KW - USK772NS56 KW - Index Medicus KW - oxidative stress. KW - cell culture KW - metal oxides KW - cytotoxicity KW - nanoparticles KW - Gene Expression -- drug effects KW - Reactive Oxygen Species -- metabolism KW - Microscopy, Electron, Transmission KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Humans KW - Cell Culture Techniques KW - Surface Properties KW - Lanthanum -- toxicity KW - Respiratory Mucosa -- cytology KW - Respiratory Mucosa -- drug effects KW - Oxidative Stress -- genetics KW - Oxides -- toxicity KW - Nanoparticles -- toxicity KW - Cobalt -- toxicity KW - Epithelial Cells -- metabolism KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- pathology KW - Cobalt -- chemistry KW - Oxidative Stress -- drug effects KW - Oxides -- chemistry KW - Lanthanum -- chemistry KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777075183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Toxicological+Assessment+of+CoO+and+La2O3+Metal+Oxide+Nanoparticles+in+Human+Small+Airway+Epithelial+Cells.&rft.au=Sisler%2C+Jennifer+D%3BPirela%2C+Sandra+V%3BShaffer%2C+Justine%3BMihalchik%2C+Amy+L%3BChisholm%2C+William+P%3BAndrew%2C+Michael+E%3BSchwegler-Berry%2C+Diane%3BCastranova%2C+Vincent%3BDemokritou%2C+Philip%3BQian%2C+Yong&rft.aulast=Sisler&rft.aufirst=Jennifer&rft.date=2016-04-01&rft.volume=150&rft.issue=2&rft.spage=418&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfw005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-27 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cell. 1995 Jan 27;80(2):179-85 [7834738] Toxicol Appl Pharmacol. 2004 Apr 1;196(1):95-107 [15050411] Nucl Med Biol. 1996 Apr;23(3):229-34 [8782230] Toxicol Appl Pharmacol. 1996 Sep;140(1):188-99 [8806885] Carcinogenesis. 2005 Apr;26(4):725-31 [15677631] Science. 2006 Feb 3;311(5761):622-7 [16456071] J Environ Sci Health A Tox Hazard Subst Environ Eng. 2006;41(12):2699-711 [17114101] Environ Health Perspect. 2007 Jun;115(6):A290 [17589571] Cancer Res. 2008 Apr 15;68(8):2781-8 [18413745] Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 Sep-Oct;2(5):544-68 [20681021] Mol Brain. 2010;3(1):30 [20974010] Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 May-Jun;3(3):298-306 [21384562] Nanotoxicology. 2011 Jun;5(2):228-35 [21609138] J Occup Environ Med. 2011 Jun;53(6 Suppl):S14-7 [21606847] Med Hypotheses. 2011 Aug;77(2):174-8 [21530094] Antioxid Redox Signal. 2011 Sep 15;15(6):1583-606 [21473702] Rev Environ Health. 2011;26(4):251-68 [22435324] ACS Nano. 2012 May 22;6(5):4349-68 [22502734] Nanotoxicology. 2013 Jun;7(4):417-31 [22393878] Biomed Res Int. 2014;2014:761264 [24587990] Immunol Lett. 2014 Mar-Apr;158(1-2):79-87 [24316409] Cold Spring Harb Perspect Biol. 2014 Mar;6(3). pii: a008912. doi: 10.1101/cshperspect.a008912 [24591517] Nat Commun. 2014;5:3514 [24675174] J Nanosci Nanotechnol. 2014 Jan;14(1):730-43 [24730293] Part Fibre Toxicol. 2014;11:20 [24885440] Toxicol Lett. 2014 Aug 4;228(3):157-69 [24821434] Nanotoxicology. 2014 Aug;8 Suppl 1:216-25 [24479615] Part Fibre Toxicol. 2014;11:44 [25183210] Acta Neurochir Suppl. 2015;120:131-5 [25366612] Nanomedicine (Lond). 2014 Dec;9(18):2803-15 [24823434] Chem Biol Interact. 2015 Jan 25;226:58-71 [25437709] Environ Sci Technol. 2015 Jan 20;49(2):1105-12 [25563693] Trends Plant Sci. 2015 May;20(5):269-72 [25795237] Int J Nanomedicine. 2015;10:3013-29 [25945048] Toxicology. 2015 Jul 3;333:25-36 [25797581] Nanotoxicology. 2015;9(7):871-85 [25672815] J Exp Biol. 2000 Apr;203(Pt 8):1253-63 [10729275] Trends Pharmacol Sci. 2000 Jul;21(7):249-52 [10979862] J Inorg Biochem. 2003 Aug 1;96(2-3):271-8 [12888263] Cell. 2004 Jan 23;116(2):191-203 [14744431] Cell. 1995 Jan 27;80(2):225-36 [7834742] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfw005 ER - TY - JOUR T1 - Contribution of ionic silver to genotoxic potential of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by the cytokinesis-block micronucleus assay AN - 1776665555; PQ0002778919 AB - Extensive human exposure to food- and cosmetics-related consumer products containing nanosilver is of public concern because of the lack of information about their safety. Genotoxicity is an important endpoint for the safety and health hazard assessment of regulated products including nanomaterials. The in vitro cytokinesis-block micronucleus (CBMN) assay is a very useful test for predictive genotoxicity testing. Recently, we have reported the genotoxicity of 20nm nanosilver in human liver HepG2 and colon Caco2 cells evaluated using the CBMN assay. The objective of our present study was three-fold: (i) to evaluate if HepG2 and Caco2 cells are valuable in vitro models for rapid genotoxicity screening of nanosilver; (ii) to test the hypothesis that the nanoparticle size and cell types are critical determinants of its genotoxicity; and (iii) to determine if ionic silver contributes to the nanosilver genotoxicity. With these objectives in mind, we evaluated the genotoxic potential of 50nm nanosilver of the same shape, composition, surface charge, obtained from the same commercial source, under the same experimental conditions and the same genotoxic CBMN endpoint used for the previously tested 20nm silver. The ionic silver (silver acetate) was also evaluated under the same conditions. Results of our study show that up to the concentrations tested in these cell types, the smaller (20nm) nanosilver induces micronucleus formation in both the cell types but the larger (50nm) nanosilver and the ionic silver provide a much weaker response compared with controls under the same conditions. Recently, we have reported the genotoxicity of 20nm nanosilver evaluated using the in vitro cytokinesis-block micronucleus (CBMN) assay. In this study, we evaluated the genotoxic potential of 50nm nanosilver of the same shape, composition, surface charge, obtained from the same commercial source, under the same experimental conditions and the same genotoxic CBMN endpoint used for the previously tested 20nm silver. The ionic silver (silver acetate) was also evaluated under the same conditions. Results of our study show that up to the concentrations tested in these cell types, the smaller (20nm) nanosilver induces micronucleus formation in both the cell types but the larger (50nm) nanosilver and the ionic silver provide much weaker response compared with controls under the same conditions. JF - Journal of Applied Toxicology AU - Sahu, Saura C AU - Roy, Shambhu AU - Zheng, Jiwen AU - Ihrie, John AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD, 20708, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 532 EP - 542 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 36 IS - 4 SN - 0260-437X, 0260-437X KW - Environment Abstracts; Toxicology Abstracts KW - Consumer products KW - Food KW - Safety KW - Genotoxicity KW - Assays KW - Genotoxicity testing KW - Surface charge KW - Acetic acid KW - Nanotechnology KW - Health risks KW - Colon KW - Cell size KW - Liver KW - Consumers KW - Silver KW - nanoparticles KW - Public concern KW - nanotechnology KW - X 24340:Cosmetics, Toiletries & Household Products KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776665555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Contribution+of+ionic+silver+to+genotoxic+potential+of+nanosilver+in+human+liver+HepG2+and+colon+Caco2+cells+evaluated+by+the+cytokinesis-block+micronucleus+assay&rft.au=Sahu%2C+Saura+C%3BRoy%2C+Shambhu%3BZheng%2C+Jiwen%3BIhrie%2C+John&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2016-04-01&rft.volume=36&rft.issue=4&rft.spage=532&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3279 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Colon; Food; Cell size; Genotoxicity; Liver; Genotoxicity testing; Consumers; Surface charge; nanoparticles; Acetic acid; Silver; nanotechnology; Health risks; Consumer products; Safety; Assays; Public concern; Nanotechnology DO - http://dx.doi.org/10.1002/jat.3279 ER - TY - JOUR T1 - Hearing difficulty and tinnitus among U.S. workers and non-workers in 2007 AN - 1776649857; PQ0002778722 AB - Background Hearing loss and tinnitus are two potentially debilitating physical conditions affecting many people in the United States. The purpose of this study was to estimate the prevalence of hearing difficulty, tinnitus, and their co-occurrence within U.S. populations. Methods Data from the 2007 National Health Interview Survey (NHIS) were examined. Weighted prevalence and adjusted prevalence ratios for self-reported hearing difficulty, tinnitus, and their co-occurrence were estimated and compared by demographic, among workers with and without occupational noise exposure, and across industries and occupations. Results Seven percent of U.S. workers never exposed to occupational noise had hearing difficulty, 5% had tinnitus and 2% had both conditions. However, among workers who had ever been exposed to occupational noise, the prevalence was 23%, 15%, and 9%, respectively (P<0.0001). Conclusions Hearing difficulty and tinnitus are prevalent in the U.S.; especially among noise-exposed workers. Improved strategies for hearing conservation or better implementation are needed. Am. J. Ind. Med. 59:290-300, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Masterson, Elizabeth A AU - Themann, Christa L AU - Luckhaupt, Sara E AU - Li, Jia AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations and Field Studies, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 290 EP - 300 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 4 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Demography KW - USA KW - Noise levels KW - Hearing loss KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776649857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Hearing+difficulty+and+tinnitus+among+U.S.+workers+and+non-workers+in+2007&rft.au=Masterson%2C+Elizabeth+A%3BThemann%2C+Christa+L%3BLuckhaupt%2C+Sara+E%3BLi%2C+Jia%3BCalvert%2C+Geoffrey+M&rft.aulast=Masterson&rft.aufirst=Elizabeth&rft.date=2016-04-01&rft.volume=59&rft.issue=4&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22565 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Demography; Noise levels; Hearing loss; Occupational exposure; USA DO - http://dx.doi.org/10.1002/ajim.22565 ER - TY - JOUR T1 - An ornamental plant targets epigenetic signaling to block cancer stem cell-driven colon carcinogenesis. AN - 1776085522; 26785732 AB - Phytochemicals modulate key cellular signaling pathways and have proven anticancer effects. Alcea rosea(AR; Hollyhock) is an ornamental plant with known anti-inflammatory properties. This study explored its role as an anticancer agent. The AR seed extract (AR extract) inhibited proliferation and colony formation in a dose- and time-dependent manner and promoted apoptosis as was evidenced by cleavage of PARP and increased expression of Bax accompanying reduced levels of BCL-xl protein in HCT116 and SW480 cells, respectively. In addition, AR extract-arrested cells at Go/G1 phase of cell cycle and exhibited decreases in Cyclin D1. AR extract-treated cells exhibited reduced number and size of colonospheres in a dose-dependent manner concomitant with decreases in cancer stem cell (CSC) markers ALDH1A1 and Dclk1. Relative levels of β-catenin, Notch-ICD, Hes1 and EZH2 were also attenuated by AR extract. TOP-flash reporter activity, a measure of Wnt signaling, decreased significantly in response to treatment while overexpression of wild type but not mutant EZH2, reversed the inhibitory effects. Moreover, WIF1 (a Wnt antagonist) promoter activity increased dramatically following treatment with AR extract which phenocopied increases in WIF1 reporter activity following EZH2 knockdown.In vivo, AR extract attenuated tumor growth due probably to reduced levels of EZH2, β-catenin, CyclinD1 and Ki-67 along with reduced levels of CSC markers. Since partial purification via HPLC yielded a prominent peak, efforts are underway to identify the active ingredient(s). Taken together, the results clearly suggest that AR extract/active component(s) can be an effective preventative/therapeutic agent to target colon cancer. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Carcinogenesis AU - Ahmed, Ishfaq AU - Roy, Badal C AU - Subramaniam, Dharmalingam AU - Ganie, Showkat Ahmad AU - Kwatra, Deep AU - Dixon, Dan AU - Anant, Shrikant AU - Zargar, Mohammad Afzal AU - Umar, Shahid AD - Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA. ; Department of Biochemistry, University of Kashmir, Srinagar 190006, India. ; Center for Drug Evaluation and Research, US Food and Drug Adminstration, Silver Spring, MD 20993, USA. ; Department of Cancer Biology and. ; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA, University of Kansas Cancer Center, Kansas City, KS 66160, USA. ; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA, University of Kansas Cancer Center, Kansas City, KS 66160, USA sumar@kumc.edu. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 385 EP - 396 VL - 37 IS - 4 KW - Index Medicus KW - Humans KW - Neoplastic Stem Cells -- pathology KW - Plants KW - Epigenesis, Genetic KW - Colonic Neoplasms -- pathology KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776085522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=An+ornamental+plant+targets+epigenetic+signaling+to+block+cancer+stem+cell-driven+colon+carcinogenesis.&rft.au=Ahmed%2C+Ishfaq%3BRoy%2C+Badal+C%3BSubramaniam%2C+Dharmalingam%3BGanie%2C+Showkat+Ahmad%3BKwatra%2C+Deep%3BDixon%2C+Dan%3BAnant%2C+Shrikant%3BZargar%2C+Mohammad+Afzal%3BUmar%2C+Shahid&rft.aulast=Ahmed&rft.aufirst=Ishfaq&rft.date=2016-04-01&rft.volume=37&rft.issue=4&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgw009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-03 N1 - Date created - 2016-03-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15178-83 [14645703] N Engl J Med. 2004 Jun 3;350(23):2343-51 [15175436] J Immunol Methods. 1984 Mar 16;67(2):379-88 [6200537] Cell. 1990 Jun 1;61(5):759-67 [2188735] Cancer Res. 1995 Apr 1;55(7):1531-9 [7882361] Cytometry. 1996 Jun 1;24(2):131-9 [8725662] Breast Cancer Res. 2005;7(3):86-95 [15987436] Am J Surg. 2006 Apr;191(4):517-26 [16531147] Cancer Res. 2006 Oct 1;66(19):9339-44 [16990346] Nat Protoc. 2006;1(5):2315-9 [17406473] Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10158-63 [17548814] Cancer J. 2007 May-Jun;13(3):192-7 [17620769] Biochem Pharmacol. 2007 Dec 3;74(11):1568-74 [17868649] J Clin Oncol. 2008 Jun 10;26(17):2795-9 [18539956] Biochem Biophys Res Commun. 2008 Dec 26;377(4):1304-8 [19000900] Trends Mol Med. 2009 May;15(5):225-33 [19362056] Int J Biochem Cell Biol. 2009 Dec;41(12):2356-9 [19666136] Cancer Res. 2009 Dec 15;69(24):9271-80 [19934310] Cancer Res. 2010 Feb 15;70(4):1469-78 [20145124] Clin Cancer Res. 2010 May 1;16(9):2580-90 [20388854] Mol Cancer. 2010;9:212 [20691072] Curr Gastroenterol Rep. 2010 Oct;12(5):340-8 [20683682] Eur J Pharm Sci. 2011 Apr 18;42(5):540-6 [21352912] CA Cancer J Clin. 2011 Jul-Aug;61(4):212-36 [21685461] Biochem Pharmacol. 2012 Jan 1;83(1):47-56 [22005519] Lancet. 2011 Dec 17;378(9809):2081-7 [22036019] Cell Cycle. 2012 Jan 1;11(1):9-10 [22157091] Mol Cancer Ther. 2012 Apr;11(4):963-72 [22319203] FEBS J. 2012 Jun;279(12):2247-59 [22521131] Int J Mol Med. 2012 Aug;30(2):337-43 [22580499] Infect Immun. 2012 Sep;80(9):3107-21 [22710872] PLoS One. 2012;7(9):e44957 [22970326] Biochem Pharmacol. 2012 Nov 1;84(9):1143-53 [22935447] Cell Biochem Funct. 2013 Apr;31(3):228-36 [22961697] Zhejiang Da Xue Xue Bao Yi Xue Ban. 2013 Sep;42(5):591-6 [24167144] Dis Colon Rectum. 2013 Dec;56(12):1373-80 [24201391] Mol Cell. 2013 Oct 24;52(2):193-205 [24055345] Cancer Biol Ther. 2014 Feb;15(2):170-1 [24365855] Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1;307(1):G1-15 [24789206] Nat Rev Microbiol. 2014 Oct;12(10):661-72 [25198138] Mol Cell Biochem. 2014 Nov;396(1-2):281-93 [25073953] Int J Mol Sci. 2015;16(5):9976-97 [25941936] Oncogene. 2015 Aug 20;34(34):4519-30 [25486432] J Cell Biochem. 2015 Nov;116(11):2517-27 [25914224] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/carcin/bgw009 ER - TY - JOUR T1 - Pharmaceuticals in the environment: An introduction to the ET&C special issue. AN - 1775635684; 27003718 JF - Environmental toxicology and chemistry AU - Williams, Mike AU - Backhaus, Thomas AU - Bowe, Craig AU - Choi, Kyungho AU - Connors, Kristin AU - Hickmann, Silke AU - Hunter, Wesley AU - Kookana, Rai AU - Marfil-Vega, Ruth AU - Verslycke, Tim AD - CSIRO Land and Water, South Australia, Australia. ; Department of Biological and Environmental Sciences, University of Gothenburg, Gothenburg, Sweden. ; Department of Science, Ohio University, Ironton, OH, USA. ; School of Public Health, Seoul National University, Seoul, Republic of Korea. ; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA. ; Environmental Risk Assessment of Pharmaceuticals, German Environment Agency, Dessau-Roßlau, Germany. ; Center for Veterinary Medicine, US Food and Drug Administration, Rockville, MD, USA. ; American Water, Belleville, IL, USA. ; Gradient, Cambridge, MA, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 763 EP - 766 VL - 35 IS - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1775635684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Pharmaceuticals+in+the+environment%3A+An+introduction+to+the+ET%26amp%3BC+special+issue.&rft.au=Williams%2C+Mike%3BBackhaus%2C+Thomas%3BBowe%2C+Craig%3BChoi%2C+Kyungho%3BConnors%2C+Kristin%3BHickmann%2C+Silke%3BHunter%2C+Wesley%3BKookana%2C+Rai%3BMarfil-Vega%2C+Ruth%3BVerslycke%2C+Tim&rft.aulast=Williams&rft.aufirst=Mike&rft.date=2016-04-01&rft.volume=35&rft.issue=4&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.3394 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-26 N1 - Date created - 2016-03-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.3394 ER - TY - JOUR T1 - Immunoexpression of Steroid Hormone Receptors and Proliferation Markers in Uterine Leiomyoma and Normal Myometrial Tissues from the Miniature Pig, Sus scrofa. AN - 1775633358; 26692562 AB - Uterine leiomyomas in miniature pet pigs occur similarly to those in women with regard to frequency, age, parity, and cycling. Clinical signs, gross, and histologic features of the porcine tumors closely resemble uterine leiomyomas (fibroids) in women. Although fibroids are hormonally responsive in women, the roles of estrogen and progesterone have not been fully elucidated. In this study, immunohistochemistry was used to assess the expression of the steroid hormone receptors, estrogen receptor alpha (ER-α), estrogen receptor beta (ER-β) and progesterone receptor (PR), and cell proliferation markers, proliferating cell nuclear antigen (PCNA) and Ki-67 in tumor and matched myometrial tissues sampled from miniature pigs. A "quickscore" method was used to determine receptor expression and labeling indices were calculated for the markers. ER-α/β and PR were localized to the nuclei of smooth muscle cells in both tissues. PR expression was intense and diffuse throughout all tissues, with correlation between tumors and matched myometria. Conversely, ER-α expression was variable between the myometrial and tumor tissues, as well as between animals. ER-β expression was low. PCNA and Ki-67 were localized to the nucleus and expression varied among tumors; however, normal tissues were overall negative. These findings support further investigation into the use of the miniature pig as a model of fibroids in women. © The Author(s) 2015. JF - Toxicologic pathology AU - Mozzachio, Kristie AU - Moore, Alicia B AU - Kissling, Grace E AU - Dixon, Darlene AD - Mozzachio Veterinary Services, Hillsborough, North Carolina, USA. ; Molecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP, Research Triangle Park, North Carolina, USA. ; Biostatistics Branch, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, North Carolina, USA. ; Molecular Pathogenesis Group, National Toxicology Program Laboratory (NTPL), Division of the NTP, Research Triangle Park, North Carolina, USA dixon@niehs.nih.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 450 EP - 457 VL - 44 IS - 3 KW - Biomarkers KW - 0 KW - Ki-67 Antigen KW - Proliferating Cell Nuclear Antigen KW - Receptors, Estrogen KW - Receptors, Progesterone KW - Index Medicus KW - uterine leiomyoma KW - fibroid KW - miniature pig KW - steroid hormone receptors KW - proliferation markers KW - immunoexpression KW - Swine KW - Animals KW - Receptors, Progesterone -- metabolism KW - Ki-67 Antigen -- analysis KW - Ki-67 Antigen -- metabolism KW - Swine, Miniature KW - Immunohistochemistry KW - Female KW - Receptors, Progesterone -- analysis KW - Leiomyoma -- metabolism KW - Leiomyoma -- pathology KW - Leiomyoma -- veterinary KW - Leiomyoma -- chemistry KW - Proliferating Cell Nuclear Antigen -- analysis KW - Receptors, Estrogen -- analysis KW - Receptors, Estrogen -- metabolism KW - Myometrium -- metabolism KW - Uterine Neoplasms -- pathology KW - Uterine Neoplasms -- chemistry KW - Biomarkers -- analysis KW - Uterine Neoplasms -- veterinary KW - Myometrium -- chemistry KW - Biomarkers -- metabolism KW - Myometrium -- pathology KW - Uterine Neoplasms -- metabolism KW - Proliferating Cell Nuclear Antigen -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1775633358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Immunoexpression+of+Steroid+Hormone+Receptors+and+Proliferation+Markers+in+Uterine+Leiomyoma+and+Normal+Myometrial+Tissues+from+the+Miniature+Pig%2C+Sus+scrofa.&rft.au=Mozzachio%2C+Kristie%3BMoore%2C+Alicia+B%3BKissling%2C+Grace+E%3BDixon%2C+Darlene&rft.aulast=Mozzachio&rft.aufirst=Kristie&rft.date=2016-04-01&rft.volume=44&rft.issue=3&rft.spage=450&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623315621414 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Cell Physiol. 2001 Mar;186(3):414-24 [11169981] Med Sci Monit. 2001 Sep-Oct;7(5):908-13 [11535933] Virchows Arch. 2002 Jul;441(1):53-62 [12111201] Toxicol Pathol. 2002 Sep-Oct;30(5):611-6 [12371671] Am J Obstet Gynecol. 2003 Jan;188(1):100-7 [12548202] Environ Health Perspect. 2003 Jun;111(8):1037-54 [12826476] Genes Chromosomes Cancer. 2003 Dec;38(4):349-56 [14566855] ILAR J. 2004;45(2):179-88 [15111737] Toxicol Pathol. 2004 Jul-Aug;32(4):402-7 [15307213] Fertil Steril. 2004 Oct;82 Suppl 3:1244-9 [15474102] Obstet Gynecol. 1980 Jan;55(1):20-4 [7352057] Fertil Steril. 1981 Oct;36(4):433-45 [7026295] Acta Obstet Gynecol Scand. 1985;64(4):307-9 [4024879] Am J Clin Pathol. 1990 Oct;94(4):435-8 [2220671] Am J Pathol. 1995 Jun;146(6):1556-67 [7778693] Biol Reprod. 1995 Apr;52(4):824-32 [7780004] J Clin Pathol. 1995 Sep;48(9):876-8 [7490328] J Clin Invest. 1996 Aug 1;98(3):777-84 [8698870] Epidemiology. 1996 Jul;7(4):440-2 [8793374] Fertil Steril. 2005 Aug;84(2):474-84 [16084893] Am J Obstet Gynecol. 2005 Oct;193(4):1395-403 [16202732] J Formos Med Assoc. 2005 Dec;104(12):920-6 [16607449] Hum Pathol. 2006 Oct;37(10):1350-6 [16949924] Fertil Steril. 2007 Apr;87(4):725-36 [17430732] Mol Med. 2008 May-Jun;14(5-6):264-75 [18231572] Fertil Steril. 2008 Nov;90(5):1878-85 [18166184] Hum Genet. 2009 Apr;125(3):257-63 [19132395] Endocrinology. 2010 Jun;151(6):2433-42 [20375184] Trends Biochem Sci. 2010 Jun;35(6):315-22 [20299225] Cancer Genet Cytogenet. 2010 Oct 1;202(1):11-6 [20804914] Tohoku J Exp Med. 2010 Sep;222(1):55-61 [20814179] Vet Pathol. 2010 Nov;47(6):1071-5 [20817893] Antioxid Redox Signal. 2011 Jan 15;14(2):221-7 [20524847] Hum Reprod Update. 2011 Nov-Dec;17(6):772-90 [21788281] Science. 2011 Oct 14;334(6053):252-5 [21868628] Am J Obstet Gynecol. 2012 Mar;206(3):211.e1-9 [22244472] PLoS One. 2012;7(5):e36935 [22570742] Mol Cell Endocrinol. 2012 Jul 25;358(2):223-31 [21672608] Fertil Steril. 2012 Sep;98(3):741-751.e6 [22633281] Endocr Rev. 2013 Feb;34(1):130-62 [23303565] Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17053-8 [24082114] Hum Reprod Update. 2014 May-Jun;20(3):309-33 [24401287] Biomed Res Int. 2014;2014:521313 [25050358] Curr Opin Obstet Gynecol. 2015 Aug;27(4):276-83 [26107781] Mol Med. 2015;21:242-56 [25879625] Semin Reprod Med. 2015 Sep;33(5):357-65 [26251118] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623315621414 ER - TY - JOUR T1 - Feasibility of radiolabeled small molecule permeability as a quantitative measure of microbicide candidate toxicity. AN - 1771452152; 26772905 AB - To determine the feasibility of using quantitative changes in vaginal permeability to small molecules as a measure of candidate microbicide toxicity. Controlled, open-labeled, prospective study. Seven healthy women received a single vaginal dose of hydroxyethylcellulose gel (HEC), nonoxynol-9 (N-9) or K-Y Jelly. Each gel was radiolabeled with a small molecule ((99m)Tc-DTPA) followed by 12-h blood and urine collection. Pharmacokinetic (PK) parameters of (99m)Tc-DTPA were calculated to compare the impact of each gel on vaginal permeability. Each woman served as her own control. The Friedman test with post hoc Wilcoxon test was used to detect differences among the gels. Vaginal permeability of (99m)Tc-DTPA was highest for the N-9 radiolabel. N-9 plasma area under the concentration curve was 2.7-fold higher (p=.04), and peak concentration was threefold higher (p=.04) compared to HEC. There were no significant PK parameter differences between HEC and K-Y Jelly or between N-9 and K-Y Jelly. Cumulative dose-adjusted median (interquartile range) 12-h timed urine gamma activity was 66.70 × 10(-4)μCi (27.90-152.00) following HEC dosing, 103.00 × 10(-4)μCi (98.20-684.00) following N-9 gel dosing and 20.30 × 10(-4)μCi (11.10-55.90) following K-Y gel dosing. The differences between urine HEC and K-Y Jelly (p=.047) and between N-9 and K-Y Jelly (p=.016) were statistically significant. It is feasible to measure differences in vaginal permeability among vaginal gels using a radiolabeled small molecule, though there are permeability differences that require a nuanced understanding of gel composition to interpret the results. Establishing the safety of both vehicle and active pharmaceutical ingredient is an essential task in microbicide development, to be determined as soon as possible. This study suggests that a combination of microbicide toxicity assessments, that is, cervicovaginal permeability, inspection and histopathology, may need to be studied simultaneously. Copyright © 2016 Elsevier Inc. All rights reserved. JF - Contraception AU - Coleman, Jenell S AU - Fuchs, Edward AU - Aung, Wutyi S AU - Marzinke, Mark A AU - Bakshi, Rahul P AU - Spiegel, Hans M L AU - Robinson, Jennifer AU - Hendrix, Craig W AD - Johns Hopkins University School of Medicine, Department of Gynecology & Obstetrics; Johns Hopkins University School of Medicine Division of Clinical Pharmacology, Department of Medicine. Electronic address: colemanj@jhmi.edu. ; Johns Hopkins University School of Medicine Division of Clinical Pharmacology, Department of Medicine. ; Johns Hopkins University School of Medicine Division of Clinical Pharmacology, Department of Medicine; Johns Hopkins University School of Medicine, Department of Pathology. ; HJF-DAIDS, a Division of The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services. ; Johns Hopkins University School of Medicine, Department of Gynecology & Obstetrics; Johns Hopkins University School of Medicine Division of Clinical Pharmacology, Department of Medicine. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 331 EP - 336 VL - 93 IS - 4 KW - Anti-Infective Agents KW - 0 KW - Gels KW - K-Y jelly KW - Phosphates KW - Propylene Glycols KW - Vaginal Creams, Foams, and Jellies KW - Nonoxynol KW - 26027-38-3 KW - Cellulose KW - 9004-34-6 KW - hydroxyethylcellulose KW - 9004-62-0 KW - Glycerol KW - PDC6A3C0OX KW - Technetium Tc 99m Pentetate KW - VW78417PU1 KW - Index Medicus KW - Permeability KW - Microbicide KW - Spermicide KW - N-9 KW - HIV KW - Phosphates -- pharmacokinetics KW - Nonoxynol -- administration & dosage KW - Glycerol -- pharmacokinetics KW - Humans KW - Cellulose -- administration & dosage KW - Propylene Glycols -- administration & dosage KW - Cellulose -- analogs & derivatives KW - Glycerol -- administration & dosage KW - Prospective Studies KW - Nonoxynol -- pharmacokinetics KW - Cellulose -- pharmacokinetics KW - Adult KW - HIV Infections -- prevention & control KW - Technetium Tc 99m Pentetate -- pharmacokinetics KW - Propylene Glycols -- pharmacokinetics KW - Vaginal Creams, Foams, and Jellies -- pharmacokinetics KW - Middle Aged KW - Adolescent KW - Vaginal Creams, Foams, and Jellies -- chemistry KW - Phosphates -- administration & dosage KW - Female KW - Cell Membrane Permeability KW - Vagina -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1771452152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contraception&rft.atitle=Feasibility+of+radiolabeled+small+molecule+permeability+as+a+quantitative+measure+of+microbicide+candidate+toxicity.&rft.au=Coleman%2C+Jenell+S%3BFuchs%2C+Edward%3BAung%2C+Wutyi+S%3BMarzinke%2C+Mark+A%3BBakshi%2C+Rahul+P%3BSpiegel%2C+Hans+M+L%3BRobinson%2C+Jennifer%3BHendrix%2C+Craig+W&rft.aulast=Coleman&rft.aufirst=Jenell&rft.date=2016-04-01&rft.volume=93&rft.issue=4&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Contraception&rft.issn=1879-0518&rft_id=info:doi/10.1016%2Fj.contraception.2016.01.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: AIDS Res Hum Retroviruses. 2015 Nov;31(11):1089-97 [26066390] AIDS Res Hum Retroviruses. 2015 Nov;31(11):1109-15 [26077739] J Biomed Opt. 2013 Apr;18(4):046010 [23588808] AIDS Res Hum Retroviruses. 2011 Sep;27(9):1019-24 [21309617] J Infect Dis. 2007 Mar 1;195(5):703-10 [17262713] Sex Transm Dis. 2008 Mar;35(3):269-75 [18091028] Science. 2010 Sep 3;329(5996):1168-74 [20643915] Nat Rev Immunol. 2005 Oct;5(10):783-92 [16200081] Arzneimittelforschung. 1998 May;48(5):512-7 [9638320] J Nucl Med. 1972 Jan;13(1):107-10 [5007959] Lancet. 2002 Sep 28;360(9338):971-7 [12383665] Sex Transm Dis. 2013 Nov;40(11):854-9 [24113407] AIDS Res Hum Retroviruses. 2013 Nov;29(11):1487-95 [23885722] N Engl J Med. 2015 Feb 5;372(6):509-18 [25651245] Int J Pharm. 2003 Aug 11;261(1-2):147-52 [12878403] Arch Oral Biol. 2004 May;49(5):387-92 [15041486] Antimicrob Agents Chemother. 2004 May;48(5):1837-47 [15105142] AAPS PharmSciTech. 2004 Mar 12;5(1):E17 [15198538] Contraception. 2004 Aug;70(2):107-10 [15288213] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.contraception.2016.01.002 ER - TY - JOUR T1 - Effect of triclosan, triclocarban, 2,2',4,4'-tetrabromodiphenyl ether, and bisphenol A on the iodide uptake, thyroid peroxidase activity, and expression of genes involved in thyroid hormone synthesis. AN - 1770889211; 26827900 AB - Triclosan, triclocarban, 2,2',4,4'-tetrabromodiphenyl ether (BDE-47), and bisphenol A (BPA) have been reported to disturb thyroid hormone (TH) homeostasis. We have examined the effects of these chemicals on sodium/iodide symporter (NIS)-mediated iodide uptake and the expression of genes involved in TH synthesis in rat thyroid follicular FRTL-5 cells, and on the activity of thyroid peroxidase (TPO) using rat thyroid microsomes. All four chemicals inhibited NIS-mediated iodide uptake in a concentration-dependent manner. A decrease in the iodide uptake was also observed in the absence of sodium iodide. Kinetic studies showed that all four chemicals were non-competitive inhibitors of NIS, with the order of Ki values being triclosan300 μM, respectively. Neither BDE-47 nor BPA affected TPO activity. In conclusion, triclosan, triclocarban, BDE-47, and BPA inhibited iodide uptake, but had differential effects on the expression of TH synthesis-related genes and the activity of TPO. Published by Elsevier Ltd. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Wu, Yuanfeng AU - Beland, Frederick A AU - Fang, Jia-Long AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: jia-long.fang@fda.hhs.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 310 EP - 319 VL - 32 KW - Benzhydryl Compounds KW - 0 KW - Carbanilides KW - Endocrine Disruptors KW - Forkhead Transcription Factors KW - FoxE1 protein, rat KW - Halogenated Diphenyl Ethers KW - Iodides KW - Nuclear Proteins KW - PAX8 Transcription Factor KW - Pax8 protein, rat KW - Phenols KW - Symporters KW - Thyroid Hormones KW - Transcription Factors KW - sodium-iodide symporter KW - thyroid nuclear factor 1 KW - 2,2',4,4'-tetrabromodiphenyl ether KW - 0N97R5X10X KW - Triclosan KW - 4NM5039Y5X KW - Thyroglobulin KW - 9010-34-8 KW - triclocarban KW - BGG1Y1ED0Y KW - Iodide Peroxidase KW - EC 1.11.1.8 KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Thyroid peroxidase KW - Thyroid hormone synthesis KW - Iodide uptake KW - Thyroid disruptors KW - Iodide Peroxidase -- metabolism KW - Animals KW - Nuclear Proteins -- genetics KW - Symporters -- genetics KW - Thyroid Hormones -- metabolism KW - Transcription Factors -- genetics KW - PAX8 Transcription Factor -- genetics KW - Forkhead Transcription Factors -- genetics KW - Iodides -- metabolism KW - Cell Survival -- drug effects KW - Microsomes -- metabolism KW - Rats, Wistar KW - Gene Expression Regulation -- drug effects KW - Iodide Peroxidase -- genetics KW - Cell Line KW - Male KW - Thyroglobulin -- genetics KW - Microsomes -- drug effects KW - Endocrine Disruptors -- toxicity KW - Benzhydryl Compounds -- toxicity KW - Carbanilides -- toxicity KW - Phenols -- toxicity KW - Triclosan -- toxicity KW - Thyroid Epithelial Cells -- metabolism KW - Halogenated Diphenyl Ethers -- toxicity KW - Thyroid Epithelial Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770889211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Effect+of+triclosan%2C+triclocarban%2C+2%2C2%27%2C4%2C4%27-tetrabromodiphenyl+ether%2C+and+bisphenol+A+on+the+iodide+uptake%2C+thyroid+peroxidase+activity%2C+and+expression+of+genes+involved+in+thyroid+hormone+synthesis.&rft.au=Wu%2C+Yuanfeng%3BBeland%2C+Frederick+A%3BFang%2C+Jia-Long&rft.aulast=Wu&rft.aufirst=Yuanfeng&rft.date=2016-04-01&rft.volume=32&rft.issue=&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2016.01.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2016.01.014 ER - TY - JOUR T1 - Identification of compounds that modulate retinol signaling using a cell-based qHTS assay. AN - 1770888668; 26820057 AB - In vertebrates, the retinol (vitamin A) signaling pathway (RSP) controls the biosynthesis and catabolism of all-trans retinoic acid (atRA), which regulates transcription of genes essential for embryonic development. Chemicals that interfere with the RSP to cause abnormal intracellular levels of atRA are potential developmental toxicants. To assess chemicals for the ability to interfere with retinol signaling, we have developed a cell-based RARE (Retinoic Acid Response Element) reporter gene assay to identify RSP disruptors. To validate this assay in a quantitative high-throughput screening (qHTS) platform, we screened the Library of Pharmacologically Active Compounds (LOPAC) in both agonist and antagonist modes. The screens detected known RSP agonists, demonstrating assay reliability, and also identified novel RSP agonists including kenpaullone, niclosamide, PD98059 and SU4312, and RSP antagonists including Bay 11-7085, LY294002, 3,4-Methylenedioxy-β-nitrostyrene, and topoisomerase inhibitors (camptothecin, topotecan, amsacrine hydrochloride, and idarubicin). When evaluated in the P19 pluripotent cell, these compounds were found to affect the expression of the Hoxa1 gene that is essential for embryo body patterning. These results show that the RARE assay is an effective qHTS approach for screening large compound libraries to identify chemicals that have the potential to adversely affect embryonic development through interference with retinol signaling. Copyright © 2016 Elsevier Ltd. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Chen, Yanling AU - Sakamuru, Srilatha AU - Huang, Ruili AU - Reese, David H AU - Xia, Menghang AD - Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708, United States. Electronic address: yanling.chen@fda.hhs.gov. ; National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, United States. ; Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD 20708, United States. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 287 EP - 296 VL - 32 KW - Vitamin A KW - 11103-57-4 KW - Luciferases KW - EC 1.13.12.- KW - Index Medicus KW - LOPAC KW - Developmental toxicant KW - High-throughput screening KW - Tox21 KW - Stem cell KW - Retinol signaling KW - Animals KW - Genes, Reporter KW - Mice KW - Response Elements KW - Luciferases -- genetics KW - Signal Transduction KW - Cell Line KW - Vitamin A -- agonists KW - High-Throughput Screening Assays KW - Vitamin A -- antagonists & inhibitors KW - Vitamin A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770888668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Identification+of+compounds+that+modulate+retinol+signaling+using+a+cell-based+qHTS+assay.&rft.au=Chen%2C+Yanling%3BSakamuru%2C+Srilatha%3BHuang%2C+Ruili%3BReese%2C+David+H%3BXia%2C+Menghang&rft.aulast=Chen&rft.aufirst=Yanling&rft.date=2016-04-01&rft.volume=32&rft.issue=&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2016.01.011 LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2016.01.011 ER - TY - JOUR T1 - Diversity of Clostridium perfringens isolates from various sources and prevalence of conjugative plasmids. AN - 1769981031; 26608548 AB - Clostridium perfringens is an important pathogen, causing food poisoning and other mild to severe infections in humans and animals. Some strains of C. perfringens contain conjugative plasmids, which may carry antimicrobial resistance and toxin genes. We studied genomic and plasmid diversity of 145 C. perfringens type A strains isolated from soils, foods, chickens, clinical samples, and domestic animals (porcine, bovine and canine), from different geographic areas in the United States between 1994 and 2006, using multiple-locus variable-number tandem repeat analysis (MLVA) and/or pulsed-field gel electrophoresis (PFGE). MLVA detected the genetic diversity in a majority of the isolates. PFGE, using SmaI and KspI, confirmed the MLVA results but also detected differences among the strains that could not be differentiated by MLVA. All of the PFGE profiles of the strains were different, except for a few of the epidemiologically related strains, which were identical. The PFGE profiles of strains isolated from the same domestic animal species were clustered more closely with each other than with other strains. However, a variety of C. perfringens strains with distinct genetic backgrounds were found among the clinical isolates. Variation was also observed in the size and number of plasmids in the strains. Primers for the internal fragment of a conjugative tcpH gene of C. perfringens plasmid pCPF4969 amplified identical size fragments from a majority of strains tested; and this gene hybridized to the various-sized plasmids of these strains. The sequences of the PCR-amplified tcpH genes from 12 strains showed diversity among the tcpH genes. Regardless of the sources of the isolates, the genetic diversity of C. perfringens extended to the plasmids carrying conjugative genes. Published by Elsevier Ltd. JF - Anaerobe AU - Park, Miseon AU - Deck, Joanna AU - Foley, Steven L AU - Nayak, Rajesh AU - Songer, J Glenn AU - Seibel, Janice R AU - Khan, Saeed A AU - Rooney, Alejandro P AU - Hecht, David W AU - Rafii, Fatemeh AD - Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. ; The University of Arizona, Tucson, AZ 85721, USA. ; Iowa State University, Ames, IA 50011, USA. ; Crop Protection Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, U.S. Department of Agriculture, Peoria, IL 61604, USA. ; Division of Infectious Diseases, Loyola University Medical Center, Maywood, IL 60126, USA. ; Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Electronic address: fatemeh.rafii@fda.hhs.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 25 EP - 35 VL - 38 KW - Index Medicus KW - Epidemiology KW - Clostridium perfringens KW - Plasmid KW - PFGE KW - Diversity KW - Soil Microbiology KW - Animals KW - Base Sequence KW - Food Microbiology KW - Humans KW - Electrophoresis, Gel, Pulsed-Field KW - Foodborne Diseases KW - Cluster Analysis KW - Multilocus Sequence Typing KW - Prevalence KW - Clostridium perfringens -- isolation & purification KW - Plasmids -- genetics KW - Clostridium perfringens -- genetics KW - Clostridium Infections -- epidemiology KW - Conjugation, Genetic KW - Clostridium Infections -- microbiology KW - Plasmids -- chemistry KW - Clostridium perfringens -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1769981031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anaerobe&rft.atitle=Diversity+of+Clostridium+perfringens+isolates+from+various+sources+and+prevalence+of+conjugative+plasmids.&rft.au=Park%2C+Miseon%3BDeck%2C+Joanna%3BFoley%2C+Steven+L%3BNayak%2C+Rajesh%3BSonger%2C+J+Glenn%3BSeibel%2C+Janice+R%3BKhan%2C+Saeed+A%3BRooney%2C+Alejandro+P%3BHecht%2C+David+W%3BRafii%2C+Fatemeh&rft.aulast=Park&rft.aufirst=Miseon&rft.date=2016-04-01&rft.volume=38&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Anaerobe&rft.issn=1095-8274&rft_id=info:doi/10.1016%2Fj.anaerobe.2015.11.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.anaerobe.2015.11.003 ER - TY - JOUR T1 - Magnitude and characteristics of acute paraquat- and diquat-related illnesses in the US: 1998-2013. AN - 1767067036; 26775000 AB - Paraquat and diquat are among the most commonly used herbicides in the world. Determine the magnitude, characteristics, and root causes for acute paraquat- and diquat-related illnesses in the US METHODS: Illnesses associated with paraquat or diquat exposure occurring from 1998 through 2011 were identified from the Sentinel Event Notification System for Occupational Risks (SENSOR)-Pesticides Program, the California Department of Pesticide Regulation (CDPR) Pesticide Illness Surveillance Program (PISP), and the Incident Data System (IDS). Cases identified by the National Poison Data System (NPDS) were reviewed for the years 1998-2003 and 2006-2013. A total of 300 paraquat- and 144 diquat-related acute illnesses were identified by SENSOR, PISP, and IDS. NPDS identified 693 paraquat- and 2128 diquat-related acute illnesses. In SENSOR/PISP/IDS, illnesses were commonly low severity (paraquat=41%; diquat=81%); however, SENSOR/PISP/IDS identified 24 deaths caused by paraquat and 5 deaths associated with diquat. Nineteen paraquat-related deaths were due to ingestion, seven of which were unintentional, often due to improper storage in beverage bottles. In SENSOR/PISP/IDS, paraquat and diquat-related acute illnesses were work-related in 68% (n=203) and 29% (n=42) of cases, respectively. When herbicide application site was known, the vast majority of acute paraquat-related illnesses (81%) arose from agricultural applications. Common root causes of illness were failure to use adequate personal protective equipment (PPE), application equipment failure, and spill/splash of herbicide. Although the magnitude of acute paraquat/diquat-related illnesses was relatively low, several fatalities were identified. Many illnesses could be prevented through stricter compliance with label requirements (e.g. ensuring proper herbicide storage and PPE use), and through enhanced training of certified applicators. Published by Elsevier Inc. JF - Environmental research AU - Fortenberry, Gamola Z AU - Beckman, John AU - Schwartz, Abby AU - Prado, Joanne Bonnar AU - Graham, Lucia S AU - Higgins, Sheila AU - Lackovic, Michelle AU - Mulay, Prakash AU - Bojes, Heidi AU - Waltz, Justin AU - Mitchell, Yvette AU - Leinenkugel, Kathy AU - Oriel, Michel S AU - Evans, Elizabeth AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA. ; Public Health Institute, Oakland, CA, USA; California Department of Public Health, Richmond, CA, USA. ; Michigan Department of Health and Human Services, Lansing, MI, USA. ; Washington State Department of Health, Olympia, WA, USA. ; California Department of Pesticide Regulation, Sacramento, CA, USA. ; North Carolina Department of Health and Human Services, Raleigh, NC, USA. ; Louisiana Department of Health and Hospitals, New Orleans, LA, USA. ; Florida Department of Health, Tallahassee, FL, USA. ; Texas Department of State Health Services, Austin, TX, USA. ; Oregon Health Authority, Portland, OR, USA. ; New York State Department of Health, Albany, NY, USA. ; Iowa Department of Public Health, Des Moines, IA, USA. ; Office of Pesticide Programs, United States Environmental Protection Agency, Washington, D.C., USA. ; Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA. Electronic address: jac6@cdc.gov. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 191 EP - 199 VL - 146 KW - Herbicides KW - 0 KW - Diquat KW - A9A615U4MP KW - Paraquat KW - PLG39H7695 KW - Index Medicus KW - Acute Poisonings KW - Pesticides KW - Surveillance KW - United States KW - Occupational Exposure KW - Infant KW - Young Adult KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Child KW - Adolescent KW - Accidents, Occupational KW - Male KW - Female KW - Paraquat -- poisoning KW - Herbicides -- poisoning KW - Environmental Exposure KW - Diquat -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1767067036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Magnitude+and+characteristics+of+acute+paraquat-+and+diquat-related+illnesses+in+the+US%3A+1998-2013.&rft.au=Fortenberry%2C+Gamola+Z%3BBeckman%2C+John%3BSchwartz%2C+Abby%3BPrado%2C+Joanne+Bonnar%3BGraham%2C+Lucia+S%3BHiggins%2C+Sheila%3BLackovic%2C+Michelle%3BMulay%2C+Prakash%3BBojes%2C+Heidi%3BWaltz%2C+Justin%3BMitchell%2C+Yvette%3BLeinenkugel%2C+Kathy%3BOriel%2C+Michel+S%3BEvans%2C+Elizabeth%3BCalvert%2C+Geoffrey+M&rft.aulast=Fortenberry&rft.aufirst=Gamola&rft.date=2016-04-01&rft.volume=146&rft.issue=&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2016.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-27 N1 - Date created - 2016-02-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envres.2016.01.003 ER - TY - JOUR T1 - Flow cytometric evaluation of the contribution of ionic silver to genotoxic potential of nanosilver in human liver HepG2 and colon Caco2 cells. AN - 1765118183; 26732652 AB - Exposure to nanosilver found in food- and cosmetics-related consumer products is of public concern because of the lack of information about its safety. In this study, two widely used in vitro cell culture models, human liver HepG2 and colon Caco2 cells, and the flow cytometric micronucleus (FCMN) assay were evaluated as tools for rapid predictive screening of the potential genotoxicity of nanosilver. Recently, we reported the genotoxicity of 20 nm nanosilver using these systems. In the current study presented here, we tested the hypothesis that the nanoparticle size and cell types were critical determinants of its genotoxicity. To test this hypothesis, we used the FCMN assay to evaluate the genotoxic potential of 50 nm nanosilver of the same shape, composition, surface charge and obtained from the same commercial source using the same experimental conditions and in vitro models (HepG2 and Caco2) as previously tested for the 20 nm silver. Results of our study show that up to the concentrations tested in these cultured cell test systems, the smaller (20 nm) nanoparticle is genotoxic to both the cell types by inducing micronucleus (MN). However, the larger (50 nm) nanosilver induces MN only in HepG2 cells, but not in Caco2 cells. Also in this study, we evaluated the contribution of ionic silver to the genotoxic potential of nanosilver using silver acetate as the representative ionic silver. The MN frequencies in HepG2 and Caco2 cells exposed to the ionic silver in the concentration range tested are not statistically significant from the control values except at the top concentrations for both the cell types. Therefore, our results indicate that the ionic silver may not contribute to the MN-forming ability of nanosilver in HepG2 and Caco2 cells. Also our results suggest that the HepG2 and Caco2 cell cultures and the FCMN assay are useful tools for rapid predictive screening of a genotoxic potential of food- and cosmetics-related chemicals including nanosilver. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Sahu, Saura C AU - Njoroge, Joyce AU - Bryce, Steven M AU - Zheng, Jiwen AU - Ihrie, John AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, Laurel, MD, 20708, USA. ; Litron Laboratories, Rochester, NY, 14623, USA. ; Division of Chemistry and Material Sciences, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S.Food and Drug Administration, Silver Spring, MD, 20993, USA. ; Division of Public Health Information and Analytics, Office of Analytics and Outreach, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, 20740, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 521 EP - 531 VL - 36 IS - 4 KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - nanosilver KW - micronucleus KW - HepG2 cells KW - Caco2 cells KW - genotoxicity KW - ionic silver KW - flow cytometry KW - nanoparticles KW - silver acetate KW - Liver -- cytology KW - Micronucleus Tests KW - Hep G2 Cells KW - Liver -- drug effects KW - Humans KW - Colon -- drug effects KW - Colon -- cytology KW - Apoptosis -- drug effects KW - Toxicity Tests KW - Caco-2 Cells KW - Silver -- chemistry KW - Metal Nanoparticles -- toxicity KW - Metal Nanoparticles -- chemistry KW - Silver -- toxicity KW - Flow Cytometry KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765118183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Flow+cytometric+evaluation+of+the+contribution+of+ionic+silver+to+genotoxic+potential+of+nanosilver+in+human+liver+HepG2+and+colon+Caco2+cells.&rft.au=Sahu%2C+Saura+C%3BNjoroge%2C+Joyce%3BBryce%2C+Steven+M%3BZheng%2C+Jiwen%3BIhrie%2C+John&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2016-04-01&rft.volume=36&rft.issue=4&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3276 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-02-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3276 ER - TY - JOUR T1 - Pulmonary toxicity of indium-tin oxide production facility particles in rats. AN - 1765117283; 26472246 AB - Indium-tin oxide (ITO) is used to make transparent conductive coatings for touch-screen and liquid crystal display electronics. Occupational exposures to potentially toxic particles generated during ITO production have increased in recent years as the demand for consumer electronics continues to rise. Previous studies have demonstrated cytotoxicity in vitro and animal models have shown pulmonary inflammation and injury in response to various indium-containing particles. In humans, pulmonary alveolar proteinosis (PAP) and fibrotic interstitial lung disease have been observed in ITO facility workers. However, which indium materials or specific processes in the workplace may be the most toxic to workers is unknown. Here we examined the pulmonary toxicity of three different particle samples that represent real-life worker exposures, as they were collected at various production stages throughout an ITO facility. Indium oxide (In2O3), sintered ITO (SITO) and ventilation dust (VD) particles each caused pulmonary inflammation and damage in rats over a time course (1, 7 and 90 days post-intratracheal instillation), but SITO and VD appeared to induce greater toxicity in rat lungs than In2O3 at a dose of 1 mg per rat. Downstream pathological changes such as PAP and fibrosis were observed in response to all three particles 90 days after treatment, with a trend towards greatest severity in animals exposed to VD when comparing animals that received the same dose. These findings may inform workplace exposure reduction efforts and provide a better understanding of the pathogenesis of an emerging occupational health issue. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Badding, Melissa A AU - Fix, Natalie R AU - Orandle, Marlene S AU - Barger, Mark W AU - Dunnick, Katherine M AU - Cummings, Kristin J AU - Leonard, Stephen S AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA. ; Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA. Y1 - 2016/04// PY - 2016 DA - April 2016 SP - 618 EP - 626 VL - 36 IS - 4 KW - Air Pollutants KW - 0 KW - Dust KW - Interleukin-1beta KW - Interleukin-6 KW - Tin Compounds KW - Tumor Necrosis Factor-alpha KW - indium tin oxide KW - 71243-84-0 KW - Index Medicus KW - cytokines KW - indium-tin oxide KW - occupational exposure KW - pulmonary toxicity KW - phagocytosis KW - Animals KW - Dose-Response Relationship, Drug KW - Hydrogen-Ion Concentration KW - Interleukin-6 -- metabolism KW - Bronchoalveolar Lavage KW - Lung -- pathology KW - Rats KW - Rats, Sprague-Dawley KW - Interleukin-1beta -- metabolism KW - Lung -- drug effects KW - Tumor Necrosis Factor-alpha -- metabolism KW - Phagocytosis KW - Male KW - Tin Compounds -- toxicity KW - Pneumonia -- chemically induced KW - Air Pollutants -- toxicity KW - Pneumonia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765117283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Pulmonary+toxicity+of+indium-tin+oxide+production+facility+particles+in+rats.&rft.au=Badding%2C+Melissa+A%3BFix%2C+Natalie+R%3BOrandle%2C+Marlene+S%3BBarger%2C+Mark+W%3BDunnick%2C+Katherine+M%3BCummings%2C+Kristin+J%3BLeonard%2C+Stephen+S&rft.aulast=Badding&rft.aufirst=Melissa&rft.date=2016-04-01&rft.volume=36&rft.issue=4&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3253 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-02-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Occup Health. 2010;52(1):14-22 [19940388] Am J Respir Crit Care Med. 2010 Mar 1;181(5):458-64 [20019344] J Occup Health. 2011;53(2):51-63 [21233592] Int Arch Occup Environ Health. 2011 Jun;84(5):471-7 [20886351] J Occup Health. 2011;53(3):234-9 [21422720] Int Arch Occup Environ Health. 2012 May;85(4):447-53 [21833746] Toxicol Pathol. 2012 Jun;40(4 Suppl):7S-13S [22637736] Chest. 2012 Jun;141(6):1512-21 [22207675] Am J Ind Med. 2013 Mar;56(3):300-7 [23109040] Toxicol Sci. 2013 Oct;135(2):414-24 [23872580] PLoS One. 2014;9(6):e101310 [24977413] Inhal Toxicol. 2000 Nov;12(11):1017-36 [11015141] J Clin Invest. 2001 Jun;107(12):1529-36 [11413160] Toxicol Pathol. 2002 Jan-Feb;30(1):93-6 [11890482] J Occup Health. 2003 May;45(3):137-9 [14646287] Clin Exp Immunol. 1991 Jan;83(1):30-4 [1988228] Cytokine. 1993 Jan;5(1):57-61 [7683505] Clin Exp Immunol. 1997 Jan;107(1):175-81 [9010273] J Exp Med. 1999 Sep 20;190(6):875-80 [10499925] Eur Respir J. 2007 Feb;29(2):317-24 [17050566] Toxicol Pathol. 2007 Aug;35(5):702-14 [17763284] Occup Environ Med. 2008 Jan;65(1):51-5 [17626138] Toxicol Sci. 2009 Apr;108(2):472-81 [19176593] Chest. 2009 Aug;136(2):571-7 [19666756] J Occup Health. 2009;51(6):513-21 [19834281] J Toxicol Environ Health A. 2014;77(20):1193-209 [25208660] Ann Am Thorac Soc. 2014 Nov;11(9):1395-403 [25295756] Toxicol Sci. 2015 Mar;144(1):17-26 [25527823] PLoS One. 2015;10(4):e0124368 [25874458] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3253 ER - TY - JOUR T1 - Relationship between ambient ultraviolet radiation and Hodgkin lymphoma subtypes in the United States AN - 1805497970; PQ0002933296 AB - Background: There are few modifiable risk factors for Hodgkin lymphoma (HL), the most common cancer among young adults in Western populations. Some studies have found a reduced risk with exposure to ultraviolet radiation (UVR), but findings have been inconsistent and limited to HL as a group or the most common subtypes. Methods: We evaluated UVR and incidence of HL subtypes using data from 15 population-based cancer registries in the United States from 2001 to 2010 (n=20 021). Ground-based ambient UVR estimates were linked to county of diagnosis. Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quintiles using Poisson regression models adjusted for age, sex, race/ethnicity, diagnosis year, and registry. Results: Hodgkin lymphoma incidence was lower in the highest UVR quintile for nodular sclerosis (IRR=0.84, 95% CI=0.75-0.96, P-trend<0.01), mixed cellularity/lymphocyte-depleted (IRR=0.66, 95% CI=0.51-0.86, P-trend=0.11), lymphocyte-rich (IRR=0.71, 95% CI=0.57-0.88, P-trend<0.01), and nodular lymphocyte predominant HL (IRR=0.74, 95% CI=0.56-0.97, P-trend<0.01), but 'not otherwise specified' HL (IRR=1.19, 95% CI=0.96-1.47, P-trend=0.11). Conclusions: This is the largest study of UVR and HL subtypes covering a wide range of UVR levels; however, we lack information on personal UVR and other individual risk factors. These findings support an inverse association between UVR and HL. JF - British Journal of Cancer AU - Bowen, Emily M AU - Pfeiffer, Ruth M AU - Linet, Martha S AU - Liu, Wayne T AU - Weisenburger, Dennis D AU - Freedman, D Michal AU - Cahoon, Elizabeth K AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, 9609 Medical Center Drive, Rockville, MD 20850, USA Y1 - 2016/03/29/ PY - 2016 DA - 2016 Mar 29 SP - 826 EP - 831 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 114 IS - 7 SN - 0007-0920, 0007-0920 KW - Toxicology Abstracts KW - Hodgkin's disease KW - U.V. radiation KW - Data processing KW - Risk factors KW - Regression analysis KW - Sclerosis KW - Lymphocytes KW - Cancer KW - Ethnic groups KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1805497970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Relationship+between+ambient+ultraviolet+radiation+and+Hodgkin+lymphoma+subtypes+in+the+United+States&rft.au=Bowen%2C+Emily+M%3BPfeiffer%2C+Ruth+M%3BLinet%2C+Martha+S%3BLiu%2C+Wayne+T%3BWeisenburger%2C+Dennis+D%3BFreedman%2C+D+Michal%3BCahoon%2C+Elizabeth+K&rft.aulast=Bowen&rft.aufirst=Emily&rft.date=2016-03-29&rft.volume=114&rft.issue=7&rft.spage=826&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2015.383 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Data processing; U.V. radiation; Hodgkin's disease; Risk factors; Regression analysis; Sclerosis; Lymphocytes; Ethnic groups; Cancer DO - http://dx.doi.org/10.1038/bjc.2015.383 ER - TY - JOUR T1 - Text mining for identifying topics in the literatures about adolescent substance use and depression. AN - 1775379734; 26993983 AB - Both adolescent substance use and adolescent depression are major public health problems, and have the tendency to co-occur. Thousands of articles on adolescent substance use or depression have been published. It is labor intensive and time consuming to extract huge amounts of information from the cumulated collections. Topic modeling offers a computational tool to find relevant topics by capturing meaningful structure among collections of documents. In this study, a total of 17,723 abstracts from PubMed published from 2000 to 2014 on adolescent substance use and depression were downloaded as objects, and Latent Dirichlet allocation (LDA) was applied to perform text mining on the dataset. Word clouds were used to visually display the content of topics and demonstrate the distribution of vocabularies over each topic. The LDA topics recaptured the search keywords in PubMed, and further discovered relevant issues, such as intervention program, association links between adolescent substance use and adolescent depression, such as sexual experience and violence, and risk factors of adolescent substance use, such as family factors and peer networks. Using trend analysis to explore the dynamics of proportion of topics, we found that brain research was assessed as a hot issue by the coefficient of the trend test. Topic modeling has the ability to segregate a large collection of articles into distinct themes, and it could be used as a tool to understand the literature, not only by recapturing known facts but also by discovering other relevant topics. JF - BMC public health AU - Wang, Shi-Heng AU - Ding, Yijun AU - Zhao, Weizhong AU - Huang, Yung-Hsiang AU - Perkins, Roger AU - Zou, Wen AU - Chen, James J AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA. ; National Applied Research Laboratories, National Center for High-Performance Computing, No. 7, R&D 6th Rd., Hsinchu Science Park, Hsinchu City, 30076, Taiwan. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA. wen.zou@fda.hhs.gov. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA. jamesj.chen@fda.hhs.gov. Y1 - 2016/03/19/ PY - 2016 DA - 2016 Mar 19 SP - 279 VL - 16 KW - Index Medicus KW - Text mining KW - Depression KW - Topic model KW - Adolescent KW - Substance use KW - Adolescent Behavior KW - Humans KW - Data Mining -- methods KW - Depression -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1775379734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+public+health&rft.atitle=Text+mining+for+identifying+topics+in+the+literatures+about+adolescent+substance+use+and+depression.&rft.au=Wang%2C+Shi-Heng%3BDing%2C+Yijun%3BZhao%2C+Weizhong%3BHuang%2C+Yung-Hsiang%3BPerkins%2C+Roger%3BZou%2C+Wen%3BChen%2C+James+J&rft.aulast=Wang&rft.aufirst=Shi-Heng&rft.date=2016-03-19&rft.volume=16&rft.issue=&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=BMC+public+health&rft.issn=1471-2458&rft_id=info:doi/10.1186%2Fs12889-016-2932-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-14 N1 - Date created - 2016-03-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Pediatrics. 2000 Oct;106(4):748-55 [11015518] Proc Natl Acad Sci U S A. 2004 Apr 6;101 Suppl 1:5228-35 [14872004] Perspect Biol Med. 1986 Autumn;30(1):7-18 [3797213] Bull Med Libr Assoc. 1990 Jan;78(1):29-37 [2403828] Brief Bioinform. 2005 Mar;6(1):57-71 [15826357] Am J Psychiatry. 2005 Aug;162(8):1483-93 [16055769] J Interpers Violence. 2005 Oct;20(10):1244-70 [16162488] Am J Prev Med. 2005 Oct;29(3):163-70 [16168864] Nat Rev Genet. 2006 Feb;7(2):119-29 [16418747] Pediatrics. 2006 Jul;118(1):189-200 [16818565] J Abnorm Psychol. 2006 Aug;115(3):524-38 [16866592] Soc Sci Med. 2007 Sep;65(6):1166-79 [17574316] J Biomed Inform. 2008 Apr;41(2):393-407 [18207462] Addiction. 2008 May;103 Suppl 1:23-35 [18426538] Addiction. 2008 Jun;103(6):969-76; discussion 977-8 [18482420] Addiction. 2008 Dec;103(12):2045-53 [18855807] Addiction. 2010 Sep;105(9):1652-9 [20707783] Prev Sci. 2010 Dec;11(4):355-9 [20422288] Alcohol Clin Exp Res. 2011 Apr;35(4):703-16 [21223307] J Am Acad Child Adolesc Psychiatry. 2009 Dec;48(12):1182-92 [19858762] BMC Bioinformatics. 2011;12 Suppl 10:S11 [22166012] Lancet. 2012 Mar 17;379(9820):1056-67 [22305766] J Interpers Violence. 2012 May;27(8):1562-78 [22080574] Psychol Med. 2012 Sep;42(9):1925-35 [22153225] Addict Behav. 2012 Dec;37(12):1314-24 [22958864] J Biomed Inform. 2013 Apr;46(2):200-11 [23159498] J Abnorm Child Psychol. 2013 Oct;41(7):1041-51 [23624771] J Interpers Violence. 2014 Jan;29(1):157-85 [24097905] BMC Syst Biol. 2013;7 Suppl 5:S10 [24564875] Addiction. 2014 Jul;109(7):1072-80 [24612217] PLoS One. 2014;9(8):e103408 [25084530] J Stud Alcohol Drugs. 2014 Sep;75(5):758-65 [25208193] Drug Alcohol Depend. 2014 Nov 1;144:225-30 [25280962] BMC Bioinformatics. 2014;15 Suppl 17:S6 [25559675] Syst Rev. 2015;4:5 [25588314] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12889-016-2932-1 ER - TY - JOUR T1 - Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice. AN - 1770889316; 26873546 AB - Identification of early biomarkers of cardiotoxicity could help initiate means to ameliorate the cardiotoxic actions of clinically useful drugs such as doxorubicin (DOX). Since DOX has been shown to target mitochondria, transcriptional levels of mitochondria-related genes were evaluated to identify early candidate biomarkers in hearts of male B6C3F1 mice given a weekly intravenous dose of 3mg/kg DOX or saline (SAL) for 2, 3, 4, 6, or 8 weeks (6, 9, 12, 18, or 24 mg/kg cumulative DOX doses, respectively). Also, a group of mice was pretreated (intraperitoneally) with the cardio-protectant, dexrazoxane (DXZ; 60 mg/kg) 30 min before each weekly dose of DOX or SAL. At necropsy a week after the last dose, increased plasma concentrations of cardiac troponin T (cTnT) were detected at 18 and 24 mg/kg cumulative DOX doses, whereas myocardial alterations were observed only at the 24 mg/kg dose. Of 1019 genes interrogated, 185, 109, 140, 184, and 451 genes were differentially expressed at 6, 9, 12, 18, and 24 mg/kg cumulative DOX doses, respectively, compared to concurrent SAL-treated controls. Of these, expression of 61 genes associated with energy metabolism and apoptosis was significantly altered before and after occurrence of myocardial injury, suggesting these as early genomics markers of cardiotoxicity. Much of these DOX-induced transcriptional changes were attenuated by pretreatment of mice with DXZ. Also, DXZ treatment significantly reduced plasma cTnT concentration and completely ameliorated cardiac alterations induced by 24 mg/kg cumulative DOX. This information on early transcriptional changes during DOX treatment may be useful in designing cardioprotective strategies targeting mitochondria. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Vijay, Vikrant AU - Moland, Carrie L AU - Han, Tao AU - Fuscoe, James C AU - Lee, Taewon AU - Herman, Eugene H AU - Jenkins, G Ronald AU - Lewis, Sherry M AU - Cummings, Connie A AU - Gao, Yuan AU - Cao, Zhijun AU - Yu, Li-Rong AU - Desai, Varsha G AD - Personalized Medicine Branch, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; Department of Mathematics, Korea University, Sejong, Republic of Korea. ; Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, The National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850-9734, United States. ; Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; UltraPath Imaging, 2228 Page Road, Durham, NC 27703, United States. ; Biomarkers and Alternative Models Branch, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; Personalized Medicine Branch, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: varsha.desai@fda.hhs.gov. Y1 - 2016/03/15/ PY - 2016 DA - 2016 Mar 15 SP - 68 EP - 84 VL - 295 KW - Antineoplastic Agents KW - 0 KW - Biomarkers KW - Cardiotonic Agents KW - Troponin T KW - Dexrazoxane KW - 048L81261F KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Mitochondria KW - Cardiotoxicity KW - Real-Time Polymerase Chain Reaction KW - Microscopy, Electron, Transmission KW - Gene Ontology KW - Animals KW - Dose-Response Relationship, Drug KW - Gene Expression KW - Energy Metabolism -- genetics KW - Troponin T -- biosynthesis KW - Mice KW - Male KW - Doxorubicin -- pharmacology KW - Dexrazoxane -- pharmacology KW - Mitochondria, Heart -- drug effects KW - Cardiotonic Agents -- pharmacology KW - Mitochondria, Heart -- genetics KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770889316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Early+transcriptional+changes+in+cardiac+mitochondria+during+chronic+doxorubicin+exposure+and+mitigation+by+dexrazoxane+in+mice.&rft.au=Vijay%2C+Vikrant%3BMoland%2C+Carrie+L%3BHan%2C+Tao%3BFuscoe%2C+James+C%3BLee%2C+Taewon%3BHerman%2C+Eugene+H%3BJenkins%2C+G+Ronald%3BLewis%2C+Sherry+M%3BCummings%2C+Connie+A%3BGao%2C+Yuan%3BCao%2C+Zhijun%3BYu%2C+Li-Rong%3BDesai%2C+Varsha+G&rft.aulast=Vijay&rft.aufirst=Vikrant&rft.date=2016-03-15&rft.volume=295&rft.issue=&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2016.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-19 N1 - Date created - 2016-03-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2016.02.003 ER - TY - JOUR T1 - Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair? AN - 1773427844; 26970737 AB - BACKGROUND Brain microglial activations and damage responses are most commonly associated with neurodegeneration or systemic innate immune system activation. Here, we used histological methods to focus on microglial responses that are directed towards brain vasculature, previously undescribed, after a neurotoxic exposure to methamphetamine. METHODS Male rats were given doses of methamphetamine that produce pronounced hyperthermia, hypertension, and toxicity. Identification of microglia and microglia-like cells (pericytes and possibly perivascular cells) was done using immunoreactivity to allograft inflammatory factor 1 (Aif1 a.k.a Iba1) and alpha M integrin (Itgam a.k.a. Cd11b) while vasculature endothelium was identified using rat endothelial cell antigen 1 (RECA-1). Regions of neuronal, axonal, and nerve terminal degeneration were determined using Fluoro-Jade C. RESULTS Dual labeling of vasculature (RECA-1) and microglia (Iba1) showed a strong association of hypertrophied cells surrounding and juxtaposed to vasculature in the septum, medial dorsal hippocampus, piriform cortex, and thalamus. The Iba1 labeling was more pronounced in the cell body while Cd11b more so in the processes of activated microglia. These regions have been previously identified to have vascular leakage after neurotoxic methamphetamine exposure. Dual labeling with Fluoro-Jade C and Iba1 indicated that there was minimal or no evidence of neuronal damage in the septum and hippocampus where many hypertrophied Iba1-labeled cells were found to be associated with vasculature. Although microglial activation around the prominent neurodegeneration was found in the thalamus, there were also many examples of activated microglia associated with vasculature. CONCLUSIONS The data implicate microglia, and possibly related cell types, in playing a major role in responding to methamphetamine-induced vascular damage, and possibly repair, in the absence of neurodegeneration. Identifying brain regions with hypertrophied/activated microglial-like cells associated with vasculature has the potential for identifying regions of more subtle examples of vascular damage and BBB compromise. JF - Journal of neuroinflammation AU - Bowyer, John F AU - Sarkar, Sumit AU - Tranter, Karen M AU - Hanig, Joseph P AU - Miller, Diane B AU - O'Callaghan, James P AD - Division of Neurotoxicology, National Center for Toxicology/FDA, Jefferson, AR, 72079, USA. John.Bowyer@fda.hhs.gov. ; Division of Neurotoxicology, National Center for Toxicology/FDA, Jefferson, AR, 72079, USA. ; Center for Drug Evaluation and Research/FDA, Silver Spring, MD, 20993, USA. ; Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA. Y1 - 2016/03/12/ PY - 2016 DA - 2016 Mar 12 SP - 64 VL - 13 IS - 1 KW - Aif1 protein, rat KW - 0 KW - Antigens, CD11b KW - Antigens, Surface KW - Calcium-Binding Proteins KW - Central Nervous System Stimulants KW - Membrane Glycoproteins KW - Microfilament Proteins KW - endothelial cell-monocyte antigens KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Hyperthermia KW - Neurotoxicity KW - Amphetamine KW - Vascular damage KW - Microglia KW - Hypertension KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Microfilament Proteins -- metabolism KW - Antigens, CD11b -- metabolism KW - Nerve Degeneration -- pathology KW - Nerve Degeneration -- chemically induced KW - Antigens, Surface -- metabolism KW - Calcium-Binding Proteins -- metabolism KW - Male KW - Membrane Glycoproteins -- metabolism KW - Central Nervous System Stimulants -- toxicity KW - Blood Vessels -- pathology KW - Microglia -- drug effects KW - Neurotoxicity Syndromes -- pathology KW - Methamphetamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773427844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroinflammation&rft.atitle=Vascular-directed+responses+of+microglia+produced+by+methamphetamine+exposure%3A+indirect+evidence+that+microglia+are+involved+in+vascular+repair%3F&rft.au=Bowyer%2C+John+F%3BSarkar%2C+Sumit%3BTranter%2C+Karen+M%3BHanig%2C+Joseph+P%3BMiller%2C+Diane+B%3BO%27Callaghan%2C+James+P&rft.aulast=Bowyer&rft.aufirst=John&rft.date=2016-03-12&rft.volume=13&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroinflammation&rft.issn=1742-2094&rft_id=info:doi/10.1186%2Fs12974-016-0526-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-14 N1 - Date created - 2016-03-14 N1 - Date revised - 2017-02-16 N1 - SuppNotes - Cited By: Acta Neuropathol. 2014 Sep;128(3):319-31 [24652058] PLoS One. 2014;9(7):e102003 [25025494] JAMA Neurol. 2015 Mar;72(3):355-62 [25599342] J Neurochem. 2015 Jun;133(5):708-21 [25753028] Nat Rev Neurosci. 2015 Jun;16(6):358-72 [25991443] J Neurosci. 2015 Jul 8;35(27):9977-89 [26156998] Neurotherapeutics. 2015 Oct;12(4):896-909 [26306439] Ernst Schering Res Found Workshop. 2002;(39):11-24 [12066409] Exp Neurol. 2004 May;187(1):47-57 [15081587] J Pharmacol Exp Ther. 2004 Oct;311(1):1-7 [15163680] Brain Res. 1980 Jul 7;193(1):153-63 [7378814] J Comp Neurol. 1980 Jul 15;192(2):333-59 [7400401] J Neurosci. 1987 Apr;7(4):931-42 [3106588] Science. 1989 Jan 20;243(4889):398-400 [2563176] Brain Pathol. 1991 Apr;1(3):193-9 [1669708] Ann N Y Acad Sci. 1992 May 11;648:371-82 [1379014] J Neurocytol. 1990 Jun;19(3):338-42 [1975269] Neuroscience. 1996 May;72(1):273-81 [8730724] Neurochem Int. 1996 Jul;29(1):25-35 [8808786] Trends Neurosci. 1996 Aug;19(8):312-8 [8843599] Neurotoxicology. 1996 Fall-Winter;17(3-4):671-8 [9086488] Synapse. 1997 Apr;25(4):350-8 [9097394] Brain Res. 1997 Jun 6;759(1):135-40 [9219871] Neurosci Lett. 1998 Jun 5;248(3):175-8 [9654337] Synapse. 1998 Nov;30(3):329-33 [9776136] Brain Res. 1998 Oct 26;809(1):77-90 [9795148] Brain Res. 2005 Feb 21;1035(1):24-31 [15713273] Brain Res. 2005 Jul 19;1050(1-2):190-8 [15987631] Curr Neurovasc Res. 2004 Jan;1(1):77-90 [16181068] J Neurochem. 2006 Feb;96(3):706-18 [16405514] Brain Res. 2006 Feb 23;1075(1):236-9 [16458862] Trends Neurosci. 2006 Sep;29(9):506-10 [16859761] Synapse. 2006 Dec 1;60(7):521-32 [16952162] J Histochem Cytochem. 2007 Jul;55(7):687-700 [17341475] Eur J Neurosci. 2007 Sep;26(5):1242-53 [17767502] Nat Neurosci. 2007 Nov;10(11):1387-94 [17965659] Ann N Y Acad Sci. 2008 Oct;1139:127-39 [18991857] Ann N Y Acad Sci. 2008 Oct;1139:318-30 [18991877] Synapse. 2009 Oct;63(10):881-94 [19582783] Neuron. 2010 Nov 4;68(3):409-27 [21040844] Nature. 2010 Nov 11;468(7321):253-62 [21068834] Brain Res. 2011 Feb 10;1373:91-100 [21156163] Cell Mol Neurobiol. 2011 Mar;31(2):175-93 [21061157] Neurotoxicology. 2012 Jun;33(3):436-43 [22525936] J Neurochem. 2012 Sep;122(5):995-1009 [22776046] J Neurosurg. 2012 Oct;117(4):781-6 [22920957] Science. 2013 Jan 11;339(6116):156-61 [23307732] BMC Genomics. 2013;14:147 [23497014] Neurotoxicology. 2013 Jul;37:40-50 [23608161] Curr Neurovasc Res. 2014 Feb;11(1):31-47 [24274907] Nat Rev Neurosci. 2014 May;15(5):300-12 [24713688] Neuron. 2014 Apr 16;82(2):380-97 [24742461] J Immunol. 2014 Sep 15;193(6):2615-21 [25193935] N1 - Last updated - 2017-02-16 DO - http://dx.doi.org/10.1186/s12974-016-0526-6 ER - TY - JOUR T1 - A study of leakage rates through mine seals in underground coal mines AN - 1798739252; PQ0002964517 AB - The National Institute for Occupational Safety and Health conducted a study on leakage rates through underground coal mine seals. Leakage rates of coal bed gas into active workings have not been well established. New seal construction standards have exacerbated the knowledge gap in our understanding of how well these seals isolate active workings near a seal line. At a western US underground coal mine, we determined seal leakage rates ranged from about 0 to 0.036 m super(3)/s for seven 340 kPa seals. The seal leakage rate varied in essentially a linear manner with variations in head pressure at the mine seals. JF - International Journal of Mining, Reclamation and Environment AU - Schatzel, Steven J AU - Krog, Robert B AU - Mazzella, Andrew AU - Hollerich, Cynthia AU - Rubinstein, Elaine AD - NIOSH, Pittsburgh, PA, USA Y1 - 2016/03/03/ PY - 2016 DA - 2016 Mar 03 SP - 165 EP - 179 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 30 IS - 2 SN - 1748-0930, 1748-0930 KW - Environment Abstracts KW - mine ventilation KW - coal mining KW - mine seals KW - coal bed emissions KW - mine safety KW - Leakage KW - Occupational safety KW - Coal KW - Mining KW - Mines KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1798739252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mining%2C+Reclamation+and+Environment&rft.atitle=A+study+of+leakage+rates+through+mine+seals+in+underground+coal+mines&rft.au=Schatzel%2C+Steven+J%3BKrog%2C+Robert+B%3BMazzella%2C+Andrew%3BHollerich%2C+Cynthia%3BRubinstein%2C+Elaine&rft.aulast=Schatzel&rft.aufirst=Steven&rft.date=2016-03-03&rft.volume=30&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mining%2C+Reclamation+and+Environment&rft.issn=17480930&rft_id=info:doi/10.1080%2F17480930.2015.1026665 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-06-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Leakage; Occupational safety; Mining; Coal; Mines DO - http://dx.doi.org/10.1080/17480930.2015.1026665 ER - TY - JOUR T1 - Identification of print-related contaminants in food packaging AN - 1780527582; PQ0002884600 AB - Since the UV ink photoinitiator (PI) isopropylthioxanthone (ITX) was discovered in packaged milk, studies of print contamination have focused primarily on PIs but have also included amine synergists. Many other substances are used or formed during the print process, yet their identity and set-off properties have yet to be catalogued in food packaging. Three different techniques: direct analysis in real-time high-resolution mass spectrometry (DART-HRMS), gas chromatography-mass spectrometry (GC-MS) and ultra-high-pressure liquid chromatography electrospray ionisation/HRMS (UHPLC/ESI-HRMS) were used to detect and identify print-related molecules from the food-contact and print surfaces of three different packages with under-cured prints. This approach tentatively identified or confirmed 110 compounds, including 35 print-related molecules. The majority of compounds identified on food-contact surfaces were packaging monomers/byproducts, solvents/plasticisers, antioxidants/degradants or slip agents/lubricants. Of these, 28 showed evidence of set-off. The identities of 16 PIs, seven known scission products and five probable PI degradants were confirmed, most showing signs of set-off. Of the print-related molecules, at least five are novel print contaminants such as 4-morpholin-4-yl-benzaldehyde or 3-phenyl-2-benzofuran-1(3H)-one. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Lago, Miguel A AU - Ackerman, Luke K AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration (USFDA), College Park, MD, USA Y1 - 2016/03/03/ PY - 2016 DA - 2016 Mar 03 SP - 518 EP - 529 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 3 SN - 1944-0049, 1944-0049 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Antioxidants KW - Food KW - Byproducts KW - Mass spectrometry KW - Mass spectroscopy KW - amines KW - Food additives KW - Gas chromatography KW - Packaging KW - Milk KW - Solvents KW - Amines KW - Food contamination KW - Spectrometry KW - Monomers KW - Liquid chromatography KW - Lubricants KW - Contaminants KW - X 24320:Food Additives & Contaminants KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780527582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Identification+of+print-related+contaminants+in+food+packaging&rft.au=Lago%2C+Miguel+A%3BAckerman%2C+Luke+K&rft.aulast=Lago&rft.aufirst=Miguel&rft.date=2016-03-03&rft.volume=33&rft.issue=3&rft.spage=518&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1136435 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Milk; Antioxidants; Food; Solvents; Food contamination; Mass spectroscopy; Monomers; Food additives; amines; Liquid chromatography; Gas chromatography; Lubricants; Contaminants; Byproducts; Mass spectrometry; Amines; Spectrometry; Packaging DO - http://dx.doi.org/10.1080/19440049.2015.1136435 ER - TY - JOUR T1 - Targeted and non-targeted detection of lemon juice adulteration by LC-MS and chemometrics AN - 1780526762; PQ0002884606 AB - Economically motivated adulteration (EMA) of lemon juice was detected by LC-MS and principal component analysis (PCA). Twenty-two batches of freshly squeezed lemon juice were adulterated by adding an aqueous solution containing 5% citric acid and 6% sucrose to pure lemon juice to obtain 30%, 60% and 100% lemon juice samples. Their total titratable acidities, degree Brix and pH values were measured, and then all the lemon juice samples were subject to LC-MS analysis. Concentrations of hesperidin and eriocitrin, major phenolic components of lemon juice, were quantified. The PCA score plots for LC-MS datasets were used to preview the classification of pure and adulterated lemon juice samples. Results showed a large inherent variability in the chemical properties among 22 batches of 100% lemon juice samples. Measurement or quantitation of one or several chemical properties (targeted detection) was not effective in detecting lemon juice adulteration. However, by using the LC-MS datasets, including both chromatographic and mass spectrometric information, 100% lemon juice samples were successfully differentiated from adulterated samples containing 30% lemon juice in the PCA score plot. LC-MS coupled with chemometric analysis can be a complement to existing methods for detecting juice adulteration. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Wang, Zhengfang AU - Jablonski, Joseph E AD - Center for Food Safety and Applied Nutrition, Division of Food Processing Science and Technology, US Food and Drug Administration (USFDA), Bedford Park, IL, USA Y1 - 2016/03/03/ PY - 2016 DA - 2016 Mar 03 SP - 560 EP - 573 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 3 SN - 1944-0049, 1944-0049 KW - Health & Safety Science Abstracts KW - Risk assessment KW - Food additives KW - Classification KW - Principal components analysis KW - Citrus limon KW - Chemical properties KW - Acidity KW - pH KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780526762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Targeted+and+non-targeted+detection+of+lemon+juice+adulteration+by+LC-MS+and+chemometrics&rft.au=Wang%2C+Zhengfang%3BJablonski%2C+Joseph+E&rft.aulast=Wang&rft.aufirst=Zhengfang&rft.date=2016-03-03&rft.volume=33&rft.issue=3&rft.spage=560&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2016.1138547 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Classification; Principal components analysis; Acidity; Chemical properties; pH; Citrus limon DO - http://dx.doi.org/10.1080/19440049.2016.1138547 ER - TY - JOUR T1 - Internal exposure to uranium in a pooled cohort of gaseous diffusion plant workers AN - 1787980691; PQ0002970900 AB - Intakes and absorbed organ doses were estimated for 29 303 workers employed at three former US gaseous diffusion plants as part of a study of cause-specific mortality and cancer incidence in uranium enrichment workers. Uranium urinalysis data (>600 000 urine samples) were available for 58 % of the pooled cohort. Facility records provided uranium gravimetric and radioactivity concentration data and allowed estimation of enrichment levels of uranium to which workers may have been exposed. Urine data were generally recorded with facility department numbers, which were also available in study subjects' work histories. Bioassay data were imputed for study subjects with no recorded sample results (33 % of pooled cohort) by assigning department average urine uranium concentration. Gravimetric data were converted to 24-h uranium activity excretion using department average specific activities. Intakes and organ doses were calculated assuming chronic exposure by inhalation to a 5- mu m activity median aerodynamic diameter aerosol of soluble uranium. Median intakes varied between 0.31 and 0.74 Bq d super(-1) for the three facilities. Median organ doses for the three facilities varied between 0.019 and 0.051, 0.68 and 1.8, 0.078 and 0.22, 0.28 and 0.74, and 0.094 and 0.25 mGy for lung, bone surface, red bone marrow, kidneys, and liver, respectively. Estimated intakes and organ doses for study subjects with imputed bioassay data were similar in magnitude. JF - Radiation Protection Dosimetry AU - Anderson, Jeri L AU - Apostoaei, A Iulian AU - Yiin, James H AU - Fleming, Donald A AU - Tseng, Chih-Yu AU - Chen, Pi-Hsueh AD - Division of Surveillance, Hazard Evaluations and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), 1090 Tusculum Ave., MS R-14., Cincinnati, OH 45226, USA, jlanderson@cdc.gov Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 471 EP - 477 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 168 IS - 4 SN - 0144-8420, 0144-8420 KW - Environment Abstracts; Toxicology Abstracts KW - Inhalation KW - Bone marrow KW - Workers KW - Chronic exposure KW - Uranium KW - Diffusion KW - Radioactivity KW - Occupational exposure KW - Mortality KW - Aerosols KW - Dosimetry KW - Organs KW - Cancer KW - Bioassays KW - Lung KW - Urine KW - Kidney KW - Liver KW - Excretion KW - Urinalysis KW - X 24390:Radioactive Materials KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787980691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Internal+exposure+to+uranium+in+a+pooled+cohort+of+gaseous+diffusion+plant+workers&rft.au=Anderson%2C+Jeri+L%3BApostoaei%2C+A+Iulian%3BYiin%2C+James+H%3BFleming%2C+Donald+A%3BTseng%2C+Chih-Yu%3BChen%2C+Pi-Hsueh&rft.aulast=Anderson&rft.aufirst=Jeri&rft.date=2016-03-01&rft.volume=168&rft.issue=4&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncv357 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Inhalation; Mortality; Aerosols; Dosimetry; Bone marrow; Cancer; Workers; Urine; Chronic exposure; Lung; Uranium; Liver; Kidney; Excretion; Diffusion; Radioactivity; Urinalysis; Occupational exposure; Organs; Bioassays DO - http://dx.doi.org/10.1093/rpd/ncv357 ER - TY - JOUR T1 - Cytochrome P450 2D6 and 3A4 enzyme inhibition by amine stimulants in dietary supplements. AN - 1781151740; 26360628 AB - A number of dietary supplements used for weight loss and athletic performance enhancement have been recently shown to contain a variety of stimulants, for which there is a lack of pharmacological and toxicological information. One concern for these emerging compounds is their potential to inhibit metabolic enzymes in the liver such as cytochromes P450 (CYP), which can lead to unexpected interactions among dietary supplements, drugs, and other xenobiotics. In this study, inhibition of human recombinant CYP2D6 and CYP3A4 by 27 amine stimulants associated with dietary supplements and their analogs was evaluated by luminescence assays. The strongest CYP2D6 inhibitors were coclaurine (IC50  = 0.14 ± 0.01 μM) and N-benzylphenethylamine (IC50  = 0.7 ± 0.2 μM), followed by several other relatively strong inhibitors (IC50 , 2-12 μM) including β-methylphenethylamine, N,β-dimethylphenethylamine (phenpromethamine), 1,3-dimethylamylamine (DMAA), N,α-diethylphenethylamine, higenamine (norcoclaurine) and N,N-diethylphenethylamine. Only nine compounds inhibited CYP3A4 by 20-55% at 100 μM. Results of this study illustrate that several amine stimulants associated with dietary supplements inhibit CYP2D6 and CYP3A4 in vitro, and these compounds may participate in adverse drug-dietary supplement interactions in vivo. Copyright © 2015 John Wiley & Sons, Ltd. Copyright © 2015 John Wiley & Sons, Ltd. JF - Drug testing and analysis AU - Liu, Yitong AU - Santillo, Michael F AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD, 20708, USA. PY - 2016 SP - 307 EP - 310 VL - 8 IS - 3-4 KW - Amines KW - 0 KW - Central Nervous System Stimulants KW - Cytochrome P-450 Enzyme Inhibitors KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP2D6 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP3A KW - Index Medicus KW - CYP3A4 KW - dietary supplements KW - CYP2D6 KW - stimulants KW - enzyme inhibition KW - Central Nervous System Stimulants -- pharmacology KW - Humans KW - Cytochrome P-450 Enzyme Inhibitors -- administration & dosage KW - In Vitro Techniques KW - Inhibitory Concentration 50 KW - Central Nervous System Stimulants -- administration & dosage KW - Cytochrome P-450 Enzyme Inhibitors -- pharmacology KW - Amines -- administration & dosage KW - Amines -- pharmacology KW - Dietary Supplements KW - Cytochrome P-450 CYP2D6 -- drug effects KW - Cytochrome P-450 CYP3A -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1781151740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+testing+and+analysis&rft.atitle=Cytochrome+P450+2D6+and+3A4+enzyme+inhibition+by+amine+stimulants+in+dietary+supplements.&rft.au=Liu%2C+Yitong%3BSantillo%2C+Michael+F&rft.aulast=Liu&rft.aufirst=Yitong&rft.date=2016-03-01&rft.volume=8&rft.issue=3-4&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Drug+testing+and+analysis&rft.issn=1942-7611&rft_id=info:doi/10.1002%2Fdta.1863 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-02 N1 - Date created - 2016-04-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/dta.1863 ER - TY - JOUR T1 - Reflections on a Science and Technology Agenda for 21st Century Disaster Risk Reduction: Based on the Scientific Content of the 2016 UNISDR Science and Technology Conference on the Implementation of the Sendai Framework for Disaster Risk Reduction 2015-2030 AN - 1780527341; PQ0002867397 AB - The first international conference for the post-2015 United Nations landmark agreements (Sendai Framework for Disaster Risk Reduction 2015-2030, Sustainable Development Goals, and Paris Agreement on Climate Change) was held in January 2016 to discuss the role of science and technology in implementing the Sendai Framework for Disaster Risk Reduction 2015-2030. The UNISDR Science and Technology Conference on the Implementation of the Sendai Framework for Disaster Risk Reduction 2015-2030 aimed to discuss and endorse plans that maximize science's contribution to reducing disaster risks and losses in the coming 15 years and bring together the diversity of stakeholders producing and using disaster risk reduction (DRR) science and technology. This article describes the evolution of the role of science and technology in the policy process building up to the Sendai Framework adoption that resulted in an unprecedented emphasis on science in the text agreed on by 187 United Nations member states in March 2015 and endorsed by the United Nations General Assembly in June 2015. Contributions assembled by the Conference Organizing Committee and teams including the conference concept notes and the conference discussions that involved a broad range of scientists and decision makers are summarized in this article. The conference emphasized how partnerships and networks can advance multidisciplinary research and bring together science, policy, and practice; how disaster risk is understood, and how risks are assessed and early warning systems are designed; what data, standards, and innovative practices would be needed to measure and report on risk reduction; what research and capacity gaps exist and how difficulties in creating and using science for effective DRR can be overcome. The Science and Technology Conference achieved two main outcomes: (1) initiating the UNISDR Science and Technology Partnership for the implementation of the Sendai Framework; and (2) generating discussion and agreement regarding the content and endorsement process of the UNISDR Science and Technology Road Map to 2030. JF - International Journal of Disaster Risk Science AU - Aitsi-Selmi, Amina AU - Murray, Virginia AU - Wannous, Chadia AU - Dickinson, Chloe AU - Johnston, David AU - Kawasaki, Akiyuki AU - Stevance, Anne-Sophie AU - Yeung, Tiffany AD - Public Health England, London, SE1 8UG, UK, virginia.murray@phe.gov.uk Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 1 EP - 29 PB - Springer Science & Business Media, Beijing VL - 7 IS - 1 SN - 2095-0055, 2095-0055 KW - Oceanic Abstracts; ASFA 2: Ocean Technology Policy & Non-Living Resources; Health & Safety Science Abstracts KW - Risk assessment KW - Stakeholders KW - Policies KW - Conferences KW - Japan, Honshu, Miyagi Prefect., Sendai KW - Climate change KW - Disasters KW - Sustainable development KW - Risk reduction KW - Freshwater KW - Warning systems KW - Risks KW - Sustainable Development KW - Committees KW - International organizations KW - Science policy KW - United Nations KW - Innovations KW - Technology KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - O 4080:Pollution - Control and Prevention KW - Q2 09392:Warning services against catastrophes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780527341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Disaster+Risk+Science&rft.atitle=Reflections+on+a+Science+and+Technology+Agenda+for+21st+Century+Disaster+Risk+Reduction%3A+Based+on+the+Scientific+Content+of+the+2016+UNISDR+Science+and+Technology+Conference+on+the+Implementation+of+the+Sendai+Framework+for+Disaster+Risk+Reduction+2015-2030&rft.au=Aitsi-Selmi%2C+Amina%3BMurray%2C+Virginia%3BWannous%2C+Chadia%3BDickinson%2C+Chloe%3BJohnston%2C+David%3BKawasaki%2C+Akiyuki%3BStevance%2C+Anne-Sophie%3BYeung%2C+Tiffany&rft.aulast=Aitsi-Selmi&rft.aufirst=Amina&rft.date=2016-03-01&rft.volume=7&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Disaster+Risk+Science&rft.issn=20950055&rft_id=info:doi/10.1007%2Fs13753-016-0081-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 100 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Policies; Sustainable Development; Conferences; Climate change; International organizations; Disasters; Warning systems; Risks; Risk assessment; Stakeholders; Sustainable development; Risk reduction; Committees; United Nations; Science policy; Technology; Innovations; Japan, Honshu, Miyagi Prefect., Sendai; Freshwater DO - http://dx.doi.org/10.1007/s13753-016-0081-x ER - TY - JOUR T1 - Fatal traumatic brain injuries in the construction industry, 2003-2010 AN - 1776668859; PQ0002763868 AB - Background Research on fatal work-related traumatic brain injuries (TBIs) is limited. This study describes fatal TBIs in the US construction industry. Methods Fatal TBIs were extracted from the Bureau of Labor Statistics Census of Fatal Occupational Injuries. Results From 2003 to 2010, 2,210 fatal TBIs occurred in construction at a rate of 2.6 per 100,000 full-time equivalent (FTE) workers. Workers aged 65 years and older had the highest fatal TBI rates among all workers (7.9 per 100,000 FTE workers). Falls were the most frequent injury event (n=1,269, 57%). Structural iron and steel workers and roofers had the highest fatal TBI rate per 100,000 FTE workers (13.7 and 11.2, respectively). Fall-related TBIs were the leading cause of death in these occupations. Conclusions A large percentage of TBIs in the construction industry were due to falls. Emphasis on safety interventions is needed to reduce these fall-related TBIs, especially among vulnerable workers. Am. J. Ind. Med. 59:212-220, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Konda, Srinivas AU - Tiesman, Hope M AU - Reichard, Audrey A AD - Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 212 EP - 220 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 3 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Mortality KW - Injuries KW - Safety KW - Occupational safety KW - Brain KW - Intervention KW - USA KW - Census KW - Vulnerability KW - Steel KW - Iron KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776668859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Fatal+traumatic+brain+injuries+in+the+construction+industry%2C+2003-2010&rft.au=Konda%2C+Srinivas%3BTiesman%2C+Hope+M%3BReichard%2C+Audrey+A&rft.aulast=Konda&rft.aufirst=Srinivas&rft.date=2016-03-01&rft.volume=59&rft.issue=3&rft.spage=212&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22557 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Mortality; Injuries; Occupational safety; Safety; Brain; Intervention; Census; Steel; Vulnerability; Iron; Construction industry; USA DO - http://dx.doi.org/10.1002/ajim.22557 ER - TY - JOUR T1 - Characterization of Antibodies for Grain-Specific Gluten Detection AN - 1776664417; PQ0002780004 AB - Gluten ingestion causes immunoglobulin E (IgE)-mediated allergy or celiac disease in sensitive individuals, and a strict gluten-free diet greatly limits food choices. Immunoassays such as enzyme-linked immunosorbent assay (ELISA) are used to quantify gluten to ensure labeling compliance of gluten-free foods. Anti-gluten antibodies may not exhibit equal affinity to gluten from wheat, rye, and barley. Moreover, because wheat gluten is commonly used as a calibrator in ELISA, accurate gluten quantitation from rye and barley contaminated foods may be compromised. Immunoassays utilizing grain-specific antibodies and calibrators may help improve gluten quantitation. In this study, polyclonal antibodies raised against gluten-containing grain-specific peptides were characterized for their immunoreactivity to gluten from different grain sources. Strong immunoreactivity to multiple gluten polypeptides from wheat, rye, and barley was observed in the range 34 to 43 kDa with anti-gliadin, 11 to 15 and 72 to 95 kDa with anti-secalin, and 30 to 43 kDa with anti-hordein peptide antibodies, respectively. Minimal or no cross-reactivity with gluten from other grains was observed among these antibodies. The anti-consensus peptide antibody raised against a repetitive amino acid sequence of proline and glutamine exhibited immunoreactivity to gluten from wheat, rye, barley, and oat. The antibodies exhibited similar immunoreactivity with most of the corresponding grain cultivars by ELISA. The high specificity and minimal cross-reactivity of grain-specific antibodies suggest their potential use in immunoassays for accurate gluten quantitation. JF - Journal of Food Science AU - Sharma, Girdhari M AU - Rallabhandi, Prasad AU - Williams, Kristina M AU - Pahlavan, Autusa AD - Immunobiology Branch, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD, 20708, U.S.A. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - T810 EP - T816 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 81 IS - 3 SN - 0022-1147, 0022-1147 KW - Environment Abstracts KW - Hordeum vulgare KW - Diets KW - Amino acids KW - Compliance KW - Ingestion KW - Food contamination KW - Allergies KW - Triticum aestivum KW - Cultivars KW - Wheat KW - Grains KW - Immunoassays KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776664417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Characterization+of+Antibodies+for+Grain-Specific+Gluten+Detection&rft.au=Sharma%2C+Girdhari+M%3BRallabhandi%2C+Prasad%3BWilliams%2C+Kristina+M%3BPahlavan%2C+Autusa&rft.aulast=Sharma&rft.aufirst=Girdhari&rft.date=2016-03-01&rft.volume=81&rft.issue=3&rft.spage=T810&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2F1750-3841.13241 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Diets; Amino acids; Compliance; Cultivars; Food contamination; Ingestion; Grains; Wheat; Allergies; Immunoassays; Hordeum vulgare; Triticum aestivum DO - http://dx.doi.org/10.1111/1750-3841.13241 ER - TY - JOUR T1 - Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease. AN - 1775178729; 26778414 AB - Hepatocellular carcinoma (HCC) is a prevalent human cancer with rising incidence worldwide. Human HCC is frequently associated with chronic liver inflammation and cirrhosis, pathophysiological processes that are a consequence of chronic viral infection, disturbances in metabolism, or exposure to chemical toxicants. To better characterize the pathogenesis of HCC, we used a human disease-relevant mouse model of fibrosis-associated hepatocarcinogenesis. In this model, marked liver tumor response caused by the promutagenic chemical N-nitrosodiethylamine in the presence of liver fibrosis was associated with epigenetic events indicative of genomic instability. Therefore, we hypothesized that DNA copy number alterations (CNAs), a feature of genomic instability and a common characteristic of cancer, are concordant between human HCC and mouse models of fibrosis-associated hepatocarcinogenesis. We evaluated DNA CNAs and changes in gene expression in the mouse liver (normal, tumor, and nontumor fibrotic tissues). Additionally, we compared our findings to DNA CNAs in human HCC cases (tumor and nontumor cirrhotic/fibrotic tissues) using publicly available data from The Cancer Genome Atlas (TCGA). We observed that while fibrotic liver tissue is largely devoid of DNA CNAs, highly frequently occurring DNA CNAs are found in mouse tumors, which is indicative of a profound increase in chromosomal instability in HCC. The cross-species gene-level comparison of CNAs identified shared regions of CNAs between human fibrosis- and cirrhosis-associated liver tumors and mouse fibrosis-associated HCC. Our results suggest that CNAs most commonly arise in neoplastic tissue rather than in fibrotic or cirrhotic liver, and demonstrate the utility of this mouse model in replicating the molecular features of human HCC. © 2016 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. JF - Cancer medicine AU - Chappell, Grace AU - Silva, Grace O AU - Uehara, Takeki AU - Pogribny, Igor P AU - Rusyn, Ivan AD - Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, Texas, 77843. ; Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, 27599. ; Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina, 27599. ; Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, 72079. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 574 EP - 585 VL - 5 IS - 3 KW - Index Medicus KW - Chromosomal instability KW - copy number alterations KW - fibrosis KW - hepatocellular carcinoma KW - cirrhosis KW - Animals KW - Humans KW - Chromosomal Instability KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Comparative Genomic Hybridization -- methods KW - DNA Copy Number Variations KW - Liver Neoplasms -- pathology KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Liver Cirrhosis -- complications KW - Liver Cirrhosis -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1775178729?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+medicine&rft.atitle=Characterization+of+copy+number+alterations+in+a+mouse+model+of+fibrosis-associated+hepatocellular+carcinoma+reveals+concordance+with+human+disease.&rft.au=Chappell%2C+Grace%3BSilva%2C+Grace+O%3BUehara%2C+Takeki%3BPogribny%2C+Igor+P%3BRusyn%2C+Ivan&rft.aulast=Chappell&rft.aufirst=Grace&rft.date=2016-03-01&rft.volume=5&rft.issue=3&rft.spage=574&rft.isbn=&rft.btitle=&rft.title=Cancer+medicine&rft.issn=2045-7634&rft_id=info:doi/10.1002%2Fcam4.606 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Lancet. 2012 Mar 31;379(9822):1245-55 [22353262] Cancer Epidemiol Biomarkers Prev. 2011 Nov;20(11):2362-8 [21921256] Hepatology. 2012 Aug;56(2):769-75 [22378017] Arch Toxicol. 2013 Feb;87(2):227-47 [23007558] Toxicol Sci. 2013 Mar;132(1):53-63 [23288052] Science. 2013 Mar 29;339(6127):1546-58 [23539594] Hepatology. 2013 Aug;58(2):706-17 [23505090] PLoS One. 2013;8(9):e72312 [24023736] Oncogene. 2013 Sep 19;32(38):4459-70 [23246960] Clin Cancer Res. 2013 Oct 15;19(20 Suppl):S4-98 [24045178] J Hepatol. 2013 Nov;59(5):1007-13 [23796475] PLoS One. 2013;8(11):e80898 [24282558] Gastroenterology. 2001 Jun;120(7):1763-73 [11375957] Cancer Res. 2001 Nov 15;61(22):8143-9 [11719443] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12963-8 [12297621] Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16226-31 [12446840] Science. 2003 Apr 18;300(5618):489-92 [12702876] Biostatistics. 2004 Oct;5(4):557-72 [15475419] Gastroenterology. 2004 Nov;127(5 Suppl 1):S35-50 [15508101] Cancer Res. 1983 Sep;43(9):4253-9 [6871863] Cancer Surv. 1996;28:247-60 [8977039] Nat Med. 1999 Jan;5(1):11-2 [9883827] Acta Pharmacol Sin. 2005 Jun;26(6):659-65 [15916730] Nat Genet. 2005 Jun;37 Suppl:S11-7 [15920524] Nat Rev Cancer. 2006 Sep;6(9):674-87 [16929323] Nat Protoc. 2008;3(6):1101-8 [18546601] Hum Mutat. 2008 Sep;29(9):1118-24 [18570184] Cytogenet Genome Res. 2008;123(1-4):176-82 [19287153] Annu Rev Genomics Hum Genet. 2009;10:451-81 [19715442] Neuro Oncol. 2010 Feb;12(2):153-63 [20150382] Nature. 2010 Feb 18;463(7283):899-905 [20164920] Semin Liver Dis. 2010 Feb;30(1):87-98 [20175036] World J Gastroenterol. 2013 Dec 21;19(47):8873-9 [24379610] Int J Cancer. 2014 Jun 15;134(12):2778-88 [24242335] Protein Cell. 2014 Sep;5(9):673-91 [24916440] Curr Protoc Pharmacol. 2014;66:14.30.1-10 [25181010] Sci Rep. 2014;4:6347 [25213199] Nat Genet. 2014 Oct;46(10):1051-9 [25151356] Genome Biol. 2014;15(12):550 [25516281] Hepatology. 2015 Mar;61(3):1066-79 [25066777] Clin Cancer Res. 2015 Apr 15;21(8):1951-61 [25248380] Breast Cancer Res Treat. 2015 Jul;152(2):347-56 [26109346] Gastroenterology. 2015 Oct;149(5):1226-1239.e4 [26099527] Cancer Med. 2016 Mar;5(3):574-85 [26778414] Mol Carcinog. 2016 May;55(5):808-17 [25865624] J Hepatol. 2010 Jun;52(6):921-9 [20385424] Dig Liver Dis. 2010 Jul;42 Suppl 3:S235-41 [20547309] BMC Gastroenterol. 2010;10:79 [20618941] Hepatology. 2011 Mar;53(3):895-904 [21374661] Cell. 2011 Mar 4;144(5):646-74 [21376230] Toxicol Pathol. 2011 Jun;39(4):678-99 [21571946] PLoS One. 2011;6(8):e22961 [21829676] Breast Cancer Res Treat. 2012 Jun;133(3):865-80 [22048815] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cam4.606 ER - TY - JOUR T1 - The Food and Drug Administration Office of Women's Health: Impact of Science on Regulatory Policy: An Update. AN - 1774164698; 26871618 AB - The U.S. Food and Drug Administration Office of Women's Health (FDA OWH) has supported women's health research for ∼20 years, funding more than 300 studies on women's health issues, including research on diseases/conditions that disproportionately affect women in addition to the evaluation of sex differences in the performance of and response to medical products. These important women's health issues are studied from a regulatory perspective, with a focus on improving and optimizing medical product development and the evaluation of product safety and efficacy in women. These findings have influenced industry direction, labeling, product discontinuation, safety notices, and clinical practice. In addition, OWH-funded research has addressed gaps in the knowledge about diseases and medical conditions that impact women across the life span such as cardiovascular disease, pregnancy, menopause, osteoporosis, and the safe use of numerous medical products. JF - Journal of women's health (2002) AU - Elahi, Merina AU - Eshera, Noha AU - Bambata, Nkosazana AU - Barr, Helen AU - Lyn-Cook, Beverly AU - Beitz, Julie AU - Rios, Maria AU - Taylor, Deborah R AU - Lightfoote, Marilyn AU - Hanafi, Nada AU - DeJager, Lowri AU - Wiesenfeld, Paddy AU - Scott, Pamela E AU - Fadiran, Emmanuel O AU - Henderson, Marsha B AD - 1 Office of Women's Health (OWH) , Food and Drug Administration, Silver Spring, Maryland. ; 2 Center for Devices and Radiological Health (CDRH) , Food and Drug Administration, Silver Spring, Maryland. ; 3 National Center for Toxicological Research (NCTR) , Food and Drug Administration, Jefferson, Arkansas. ; 4 Center for Drug Evaluation and Research (CDER) , Food and Drug Administration, Silver Spring, Maryland. ; 5 Center for Biologics Evaluation and Research (CBER) , Food and Drug Administration, Silver Spring, Maryland. ; 6 Center for Food Safety and Applied Nutrition (CFSAN) , Food and Drug Administration, Silver Spring, Maryland. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 222 EP - 234 VL - 25 IS - 3 KW - Index Medicus KW - United States KW - Policy Making KW - Humans KW - Female KW - Pregnancy KW - United States Food and Drug Administration KW - Women's Health KW - Health Policy -- trends KW - Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1774164698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+women%27s+health+%282002%29&rft.atitle=The+Food+and+Drug+Administration+Office+of+Women%27s+Health%3A+Impact+of+Science+on+Regulatory+Policy%3A+An+Update.&rft.au=Elahi%2C+Merina%3BEshera%2C+Noha%3BBambata%2C+Nkosazana%3BBarr%2C+Helen%3BLyn-Cook%2C+Beverly%3BBeitz%2C+Julie%3BRios%2C+Maria%3BTaylor%2C+Deborah+R%3BLightfoote%2C+Marilyn%3BHanafi%2C+Nada%3BDeJager%2C+Lowri%3BWiesenfeld%2C+Paddy%3BScott%2C+Pamela+E%3BFadiran%2C+Emmanuel+O%3BHenderson%2C+Marsha+B&rft.aulast=Elahi&rft.aufirst=Merina&rft.date=2016-03-01&rft.volume=25&rft.issue=3&rft.spage=222&rft.isbn=&rft.btitle=&rft.title=Journal+of+women%27s+health+%282002%29&rft.issn=1931-843X&rft_id=info:doi/10.1089%2Fjwh.2015.5671 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: N Engl J Med. 2001 Mar 15;344(11):783-92 [11248153] JAMA. 2001 Mar 14;285(10):1322-6 [11255387] Fed Regist. 1993 Jul 22;58(139):39406-16 [11645233] Rev Recent Clin Trials. 2011 Sep;6(3):220-7 [21682673] Clin Pharmacol Ther. 2012 Mar;91(3):555-7 [22297386] J AOAC Int. 2012 Mar-Apr;95(2):349-55 [22649918] J Womens Health (Larchmt). 2012 Jul;21(7):713-6 [22747427] Arch Intern Med. 2012 May 28;172(10):781-8 [22507695] Semin Immunopathol. 2012 Jul;34(4):473-8 [22526468] Med Phys. 2012 Sep;39(9):5336-46 [22957601] Heart Rhythm. 2012 Oct;9(10):1737-53 [22975672] Drug Saf. 2002;25(6):381-92 [12071774] South Med J. 2002 Jun;95(6):588-92 [12081215] Menopause. 2003 Jan-Feb;10(1):65-72 [12544679] Pharmacoepidemiol Drug Saf. 2003 Apr-May;12(3):237-41 [12733477] Paediatr Perinat Epidemiol. 2004 Mar;18(2):106-11 [14996249] Toxicol Sci. 2004 Jun;79(2):381-93 [15056818] Am J Obstet Gynecol. 2004 Aug;191(2):398-407 [15343213] J Invasive Cardiol. 2004 Sep;16(9):459-64 [15353824] Lancet. 1994 May 28;343(8909):1318-21 [7910323] Biol Reprod. 1996 Jan;54(1):160-7 [8838013] Biol Reprod. 1997 May;56(5):1239-44 [9160724] Carcinogenesis. 1997 Oct;18(10):1949-54 [9364005] J Invasive Cardiol. 2005 Dec;17(12):644-50 [16327045] J Pharmacol Exp Ther. 2006 Mar;316(3):1098-106 [16278312] N Engl J Med. 2006 Jun 8;354(23):2443-51 [16760444] J Acquir Immune Defic Syndr. 2006 Nov 1;43(3):304-12 [17019363] Pharmacoepidemiol Drug Saf. 2007 Feb;16(2):125-31 [16981230] Am J Obstet Gynecol. 2007 Jun;196(6):544.e1-5 [17547888] JAMA. 2007 Jul 18;298(3):317-23 [17635892] J Womens Health (Larchmt). 2007 Jul-Aug;16(6):807-17 [17678451] Spine (Phila Pa 1976). 2007 Aug 15;32(18):E505-11 [17700430] Pharmacoepidemiol Drug Saf. 2008 Mar;17(3):240-7 [18200619] Clin Vaccine Immunol. 2014 Mar;21(3):391-8 [24403525] Br J Clin Pharmacol. 2014 Mar;77(3):554-70 [23834474] JACC Heart Fail. 2013 Jun;1(3):237-44 [24621876] Clin Pharmacol Ther. 2014 May;95(5):501-8 [24336137] Clin Pharmacol Ther. 2014 May;95(5):478-80 [24747236] Nephrol Dial Transplant. 2014 Jun;29(6):1177-85 [24569495] JAMA Intern Med. 2014 Aug;174(8):1340-8 [25090172] J Am Coll Cardiol. 2014 Sep 2;64(9):887-94 [25169173] J Am Coll Cardiol. 2014 Sep 2;64(9):895-7 [25169174] Clin Pharmacol Ther. 2014 Nov;96(5):549-58 [25054430] J Agric Food Chem. 2015 Feb 18;63(6):1825-32 [25619974] Circ Cardiovasc Qual Outcomes. 2015 Mar;8(2 Suppl 1):S4-11 [25714821] J Am Heart Assoc. 2015 Apr;4(4). pii: e001615. doi: 10.1161/JAHA.114.001615 [25870186] Hypertension. 2008 Apr;51(4):960-9 [18259046] Menopause. 2008 Jul-Aug;15(4 Pt 1):628-38 [18340277] Womens Health Issues. 2009 Mar-Apr;19(2):89-93 [19272558] J Womens Health (Larchmt). 2009 Mar;18(3):303-10 [19243271] J AOAC Int. 2009 May-Jun;92(3):846-54 [19610377] Clin Pharmacol Ther. 2009 Aug;86(2):167-74 [19440187] Clin Pharmacol Ther. 2009 Aug;86(2):136-8 [19621009] J Clin Microbiol. 2010 Jan;48(1):281-5 [19906903] Regul Toxicol Pharmacol. 2011 Feb;59(1):111-24 [20920542] Arch Pathol Lab Med. 2011 Feb;135(2):233-42 [21284444] Med Phys. 2010 Dec;37(12):6253-70 [21302782] BMC Med. 2011;9:65 [21624134] Med Phys. 2011 Oct;38(10):5601-11 [21992378] BMJ. 2011;343:d5931 [22010128] BMJ. 2011;343:d6667 [22010131] Drug Metab Dispos. 2013 Apr;41(4):801-13 [23355638] Med Phys. 2013 May;40(5):051914 [23635284] J Pharm Sci. 2013 Jun;102(6):1905-14 [23568279] Am J Med. 2013 Jun;126(6):472-9 [23561631] J Womens Health (Larchmt). 2013 Jul;22(7):604-16 [23768021] PLoS One. 2013;8(10):e75305 [24116033] PLoS One. 2013;8(11):e79543 [24255707] Nat Biotechnol. 2014 Jan;32(1):40-51 [24406927] Obstet Gynecol. 2014 Jan;123(1):161-5 [24463677] Nat Commun. 2014;5:3230 [24510058] J Electrocardiol. 2015 Jul-Aug;48(4):533-8 [25796102] Am J Ther. 2015 Nov-Dec;22(6):435-55 [25621972] Mod Pathol. 2000 Mar;13(3):285-94 [10757339] Clin Pharmacol Ther. 2000 Apr;67(4):413-8 [10801251] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1089/jwh.2015.5671 ER - TY - JOUR T1 - Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss. AN - 1770221608; 26161573 AB - Certain phthalates and bisphenol A (BPA) show reproductive effects in animal studies and potentially affect human ovulation, conception, and pregnancy loss. We investigated these chemicals in relation to follicular- and luteal-phase lengths, time to pregnancy, and early pregnancy loss (within 6 weeks of the last menstrual period) among women attempting pregnancy. Women discontinuing contraception provided daily first-morning urine specimens and recorded days with vaginal bleeding for up to 6 months. Specimens had previously been analyzed for estrogen and progesterone metabolites and human chorionic gonadotropin. A total of 221 participants contributed 706 menstrual cycles. We measured 11 phthalate metabolites and BPA in pooled urine from three specimens spaced throughout each menstrual cycle. We analyzed associations between chemical concentrations and outcomes using linear mixed models for follicular- and luteal-phase lengths, discrete-time fecundability models for time to pregnancy, and logistic regression for early pregnancy loss. Higher concentrations of monocarboxyoctyl phthalate (MCOP) were associated with shorter luteal phase [2nd tertile vs. 1st tertile: -0.5 days (95% CI: -0.9, -0.1), 3rd vs. 1st: -0.4 days (95% CI: -0.8, 0.01), p = 0.04]. BPA was also associated with shorter luteal phase [2nd vs. 1st: -0.8 days (95% CI: -1.2, -0.4), 3rd vs. 1st: -0.4 days (95% CI: -0.8, 0.02), p = 0.001]. BPA and MCOP (or its precursors) were associated with shorter luteal phase. Menstrual cycle-specific estimates of urinary BPA and phthalate metabolites were not associated with detrimental alterations in follicular-phase length, time to pregnancy, or early pregnancy loss, and in fact, DEHP [di(2-ethylhexyl) phthalate] metabolites {MEOHP [mono(2-ethyl-5-oxohexyl) phthalate] and ΣDEHP} were associated with reduced early loss. These findings should be confirmed in future human studies. JF - Environmental health perspectives AU - Jukic, Anne Marie AU - Calafat, Antonia M AU - McConnaughey, D Robert AU - Longnecker, Matthew P AU - Hoppin, Jane A AU - Weinberg, Clarice R AU - Wilcox, Allen J AU - Baird, Donna D AD - Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Durham, North Carolina, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 321 EP - 328 VL - 124 IS - 3 KW - Benzhydryl Compounds KW - 0 KW - Environmental Pollutants KW - Phenols KW - Phthalic Acids KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Pregnancy Trimester, First KW - Humans KW - Adult KW - Female KW - Pregnancy KW - Environmental Pollutants -- toxicity KW - Phenols -- toxicity KW - Environmental Pollutants -- urine KW - Follicular Phase -- drug effects KW - Phthalic Acids -- urine KW - Phthalic Acids -- toxicity KW - Benzhydryl Compounds -- urine KW - Benzhydryl Compounds -- toxicity KW - Abortion, Spontaneous -- chemically induced KW - Abortion, Spontaneous -- urine KW - Luteal Phase -- drug effects KW - Phenols -- urine KW - Fertility -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770221608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Urinary+Concentrations+of+Phthalate+Metabolites+and+Bisphenol+A+and+Associations+with+Follicular-Phase+Length%2C+Luteal-Phase+Length%2C+Fecundability%2C+and+Early+Pregnancy+Loss.&rft.au=Jukic%2C+Anne+Marie%3BCalafat%2C+Antonia+M%3BMcConnaughey%2C+D+Robert%3BLongnecker%2C+Matthew+P%3BHoppin%2C+Jane+A%3BWeinberg%2C+Clarice+R%3BWilcox%2C+Allen+J%3BBaird%2C+Donna+D&rft.aulast=Jukic&rft.aufirst=Anne&rft.date=2016-03-01&rft.volume=124&rft.issue=3&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408164 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Res. 2011 Jul;111(5):718-26 [21349512] Neurotoxicol Teratol. 2011 Sep-Oct;33(5):558-66 [21854843] Environ Sci Technol. 2012 Jan 3;46(1):477-85 [22085025] Occup Environ Med. 2005 Nov;62(11):806-18 [16234408] Toxicol Sci. 2006 Sep;93(1):189-95 [16763070] Reprod Toxicol. 2007 Feb;23(2):138-44 [17070006] J Womens Health (Larchmt). 2007 Nov;16(9):1340-7 [18001191] J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):106-12 [17997365] Trends Genet. 2008 Feb;24(2):86-93 [18192063] Mutat Res. 2008 Mar 12;651(1-2):71-81 [18093867] Environ Res. 2008 Oct;108(2):260-7 [18774129] Reprod Toxicol. 2008 Oct;26(2):94-9 [18638542] Biol Reprod. 2009 May;80(5):1066-71 [19164168] Toxicol Lett. 2009 Aug 25;189(1):14-20 [19410640] Fertil Steril. 1999 Jan;71(1):40-9 [9935114] Am J Epidemiol. 1999 Mar 15;149(6):550-7 [10084244] Mol Hum Reprod. 2005 Jun;11(6):389-96 [15879462] Anal Chem. 2005 Aug 15;77(16):5407-13 [16097788] Environ Res. 2009 Aug;109(6):734-7 [19463991] Int J Hyg Environ Health. 2009 Sep;212(5):481-91 [19394271] J Expo Sci Environ Epidemiol. 2010 Mar;20(2):169-75 [19277068] Int J Androl. 2010 Apr;33(2):385-93 [20002217] Reprod Toxicol. 2010 Nov;30(3):393-400 [20599497] Environ Health Perspect. 2012 Mar;120(3):458-63 [22113848] Environ Health Perspect. 2012 May;120(5):739-45 [22262702] Hum Reprod. 2012 Dec;27(12):3583-92 [23014629] Crit Rev Toxicol. 2013 Mar;43(3):200-19 [23405971] Toxicol Appl Pharmacol. 2013 Apr 1;268(1):47-54 [23360888] Int J Hyg Environ Health. 2013 Nov;216(6):735-42 [23474103] Environ Health Perspect. 2014 Mar;122(3):235-41 [24425099] Environ Health Perspect. 2014 May;122(5):521-8 [24577876] Fertil Steril. 2014 May;101(5):1359-66 [24534276] Environ Sci Technol. 2014 Jun 17;48(12):7018-25 [24845688] Environ Health Perspect. 2015 Jul;123(7):705-11 [25782115] Reprod Toxicol. 2001 Jan-Feb;15(1):71-4 [11137380] Epidemiology. 2002 Nov;13(6):675-84 [12410009] Curr Biol. 2003 Apr 1;13(7):546-53 [12676084] Am J Epidemiol. 1986 Sep;124(3):470-80 [3740046] N Engl J Med. 1988 Jul 28;319(4):189-94 [3393170] Lancet. 1988 Dec 24-31;2(8626-8627):1453-6 [2904572] Am J Epidemiol. 1989 May;129(5):1072-8 [2705427] Epidemiology. 1990 Sep;1(5):382-5 [2078614] Stat Med. 1991 Feb;10(2):255-66 [2052803] Epidemiology. 1994 Sep;5(5):484-9 [7986861] N Engl J Med. 1995 Dec 7;333(23):1517-21 [7477165] Environ Health Perspect. 1997 Feb;105 Suppl 1:249-50 [9114309] Int J Cancer. 1998 Jan 19;75(2):290-4 [9462721] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408164 ER - TY - JOUR T1 - Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice. AN - 1770221561; 26295903 AB - Mice exposed to high levels of arsenic in utero have increased susceptibility to tumors such as hepatic and pulmonary carcinomas when they reach adulthood. However, the effects of in utero arsenic exposure on general physiological functions such as reproduction and metabolism remain unclear. We evaluated the effects of in utero exposure to inorganic arsenic at the U.S. Environmental Protection Agency (EPA) drinking water standard (10 ppb) and at tumor-inducing levels (42.5 ppm) on reproductive end points and metabolic parameters when the exposed females reached adulthood. Pregnant CD-1 mice were exposed to sodium arsenite [none (control), 10 ppb, or 42.5 ppm] in drinking water from gestational day 10 to birth, the window of organ formation. At birth, exposed offspring were fostered to unexposed dams. We examined reproductive end points (age at vaginal opening, reproductive hormone levels, estrous cyclicity, and fertility) and metabolic parameters (body weight changes, hormone levels, body fat content, and glucose tolerance) in the exposed females when they reached adulthood. Arsenic-exposed females (10 ppb and 42.5 ppm) exhibited early onset of vaginal opening. Fertility was not affected when females were exposed to the 10-ppb dose. However, the number of litters per female was decreased in females exposed to 42.5 ppm of arsenic in utero. In both 10-ppb and 42.5-ppm groups, arsenic-exposed females had significantly greater body weight gain, body fat content, and glucose intolerance. Our findings revealed unexpected effects of in utero exposure to arsenic: exposure to both a human-relevant low dose and a tumor-inducing level led to early onset of vaginal opening and to obesity in female CD-1 mice. JF - Environmental health perspectives AU - Rodriguez, Karina F AU - Ungewitter, Erica K AU - Crespo-Mejias, Yasmin AU - Liu, Chang AU - Nicol, Barbara AU - Kissling, Grace E AU - Yao, Humphrey Hung-Chang AD - Reproductive Developmental Biology Group, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 336 EP - 343 VL - 124 IS - 3 KW - Arsenites KW - 0 KW - Blood Glucose KW - Drinking Water KW - Environmental Pollutants KW - Gonadotropins KW - Sodium Compounds KW - sodium arsenite KW - 48OVY2OC72 KW - Index Medicus KW - Vagina -- drug effects KW - Animals KW - Vagina -- physiology KW - Prenatal Exposure Delayed Effects -- metabolism KW - Blood Glucose -- metabolism KW - Drinking Water -- chemistry KW - Mice KW - Estrous Cycle -- drug effects KW - Pregnancy KW - Gonadotropins -- blood KW - Adipose Tissue -- drug effects KW - Prenatal Exposure Delayed Effects -- physiopathology KW - Female KW - Fertility -- drug effects KW - Sexual Maturation -- drug effects KW - Environmental Pollutants -- toxicity KW - Reproduction -- drug effects KW - Arsenites -- toxicity KW - Sodium Compounds -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770221561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Effects+of+in+Utero+Exposure+to+Arsenic+during+the+Second+Half+of+Gestation+on+Reproductive+End+Points+and+Metabolic+Parameters+in+Female+CD-1+Mice.&rft.au=Rodriguez%2C+Karina+F%3BUngewitter%2C+Erica+K%3BCrespo-Mejias%2C+Yasmin%3BLiu%2C+Chang%3BNicol%2C+Barbara%3BKissling%2C+Grace+E%3BYao%2C+Humphrey+Hung-Chang&rft.aulast=Rodriguez&rft.aufirst=Karina&rft.date=2016-03-01&rft.volume=124&rft.issue=3&rft.spage=336&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1509703 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2011 Feb 15;251(1):59-69 [21134390] Arch Toxicol. 2011 Jun;85(6):653-61 [20978746] Environ Health Perspect. 2013 Aug;121(8):971-7 [23757598] Environ Health Perspect. 2011 Aug;119(8):1104-9 [21592922] Cells Tissues Organs. 2011;194(2-4):261-7 [21555858] Toxicol Appl Pharmacol. 2011 Oct 15;256(2):146-53 [21851829] Exp Toxicol Pathol. 2012 Jan;64(1-2):25-30 [20580540] PLoS One. 2012;7(5):e38249 [22693606] Curr Diabetes Rev. 2012 May;8(3):155-61 [22497653] Environ Health. 2012;11:38 [22676249] Environ Health Perspect. 2012 Oct;120(10):1353-61 [22672778] Environ Health Perspect. 2013 Feb;121(2):244-50 [23221970] Int J Epidemiol. 2013 Aug;42(4):1077-86 [24062297] Toxicol Lett. 2014 Jan 3;224(1):130-40 [24157283] Ann Intern Med. 2013 Nov 19;159(10):649-59 [24061511] JAMA Intern Med. 2014 Feb 1;174(2):298 [24493600] Biol Reprod. 2014 Feb;90(2):24 [24337314] Reprod Toxicol. 2014 Apr;44:41-9 [24090629] Arch Toxicol. 2014 Aug;88(8):1619-29 [25005685] Cancer Epidemiol Biomarkers Prev. 2014 Aug;23(8):1529-38 [24859871] Mol Endocrinol. 2014 Aug;28(8):1329-36 [24992182] Environ Health Perspect. 2014 Oct;122(10):1059-65 [24927198] Sci Rep. 2014;4:6894 [25367288] PLoS One. 2015;10(3):e0119784 [25768847] Int J Obes (Lond). 2015 Apr;39(4):702-11 [25091727] BMJ. 1999 Nov 27;319(7222):1403-7 [10574856] Environ Health Perspect. 2000 Sep;108(9):847-51 [11017889] Toxicol Lett. 2003 Jan 31;137(1-2):3-13 [12505428] Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 [12583988] Carcinogenesis. 2004 Jan;25(1):133-41 [14514661] Toxicology. 2004 May 20;198(1-3):31-8 [15138027] Biol Reprod. 1983 Nov;29(4):924-31 [6640041] J Epidemiol Community Health. 1989 Sep;43(3):237-40 [2607302] Biol Reprod. 1993 Mar;48(3):669-73 [8452942] Endocrinology. 1997 Aug;138(8):3540-7 [9231809] Diabet Med. 1998 Mar;15(3):220-7 [9545123] Teratology. 1999 Jul;60(1):13-21 [10413334] Toxicol Sci. 1999 Sep;51(1):98-107 [10496681] Toxicol Appl Pharmacol. 2005 Feb 15;203(1):53-61 [15694464] Cancer Res. 2006 Feb 1;66(3):1337-45 [16452187] Toxicology. 2006 Jul 5;224(1-2):147-55 [16753250] Toxicol Appl Pharmacol. 2007 May 1;220(3):284-91 [17350061] Int J Obes (Lond). 2007 Jun;31(6):1023-9 [17299386] Toxicol Appl Pharmacol. 2007 Aug 1;222(3):271-80 [17306315] JAMA. 2008 Aug 20;300(7):814-22 [18714061] Toxicol Appl Pharmacol. 2009 Aug 15;239(1):29-36 [19446573] Pharmacol Biochem Behav. 2010 Apr;95(2):249-57 [20138905] Reprod Toxicol. 2010 Jun;29(3):279-85 [20025959] Int J Toxicol. 2010 May-Jun;29(3):291-6 [20448261] Ann N Y Acad Sci. 2010 Sep;1205:148-55 [20840267] Toxicol Sci. 2010 Oct;117(2):404-17 [20667999] Trends Endocrinol Metab. 2010 Nov;21(11):643-51 [20846876] Pharmacol Ther. 2013 Mar;137(3):331-40 [23178510] BMC Pharmacol Toxicol. 2013;14:13 [23419080] Comment In: Environ Health Perspect. 2016 Mar;124(3):A46-7 [26930461] Environ Health Perspect. 2016 Mar;124(3):A46 [26930347] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1509703 ER - TY - JOUR T1 - Environmental Pollution: An Under-recognized Threat to Children's Health, Especially in Low- and Middle-Income Countries. AN - 1770221406; 26930243 AB - Exposures to environmental pollutants during windows of developmental vulnerability in early life can cause disease and death in infancy and childhood as well as chronic, non-communicable diseases that may manifest at any point across the life span. Patterns of pollution and pollution-related disease change as countries move through economic development. Environmental pollution is now recognized as a major cause of morbidity and mortality in low- and middle-income countries (LMICs). According to the World Health Organization, pollution is responsible for 8.9 million deaths around the world each year; of these, 94% (8.4 million) are in LMICs. Toxic chemical pollution is growing into a major threat to children's health in LMICs. The disease and disability caused by environmental pollution have great economic costs, and these costs can undercut trajectories of national development. To combat pollution, improved programs of public health and environmental protection are needed in countries at every level of development. Pollution control strategies and technologies that have been developed in high-income countries must now be transferred to LMICs to assist these emerging economies to avoid the mistakes of the past. A new international clearinghouse is needed to define and track the health effects of pollution, quantify the economic costs of these effects, and direct much needed attention to environmental pollution as a risk factor for disease. JF - Environmental health perspectives AU - Suk, William A AU - Ahanchian, Hamid AU - Asante, Kwadwo Ansong AU - Carpenter, David O AU - Diaz-Barriga, Fernando AU - Ha, Eun-Hee AU - Huo, Xia AU - King, Malcolm AU - Ruchirawat, Mathuros AU - da Silva, Emerson R AU - Sly, Leith AU - Sly, Peter D AU - Stein, Renato T AU - van den Berg, Martin AU - Zar, Heather AU - Landrigan, Philip J AD - Hazardous Substances Research Branch, Superfund Research Program, National Institute for Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - A41 EP - A45 VL - 124 IS - 3 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - World Health Organization KW - Chronic Disease -- prevention & control KW - Risk Factors KW - Humans KW - Child KW - Environmental Exposure -- prevention & control KW - Morbidity KW - Environmental Pollution -- prevention & control KW - Child Health KW - Developing Countries KW - Environmental Pollutants -- adverse effects KW - Environmental Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770221406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Environmental+Pollution%3A+An+Under-recognized+Threat+to+Children%27s+Health%2C+Especially+in+Low-+and+Middle-Income+Countries.&rft.au=Suk%2C+William+A%3BAhanchian%2C+Hamid%3BAsante%2C+Kwadwo+Ansong%3BCarpenter%2C+David+O%3BDiaz-Barriga%2C+Fernando%3BHa%2C+Eun-Hee%3BHuo%2C+Xia%3BKing%2C+Malcolm%3BRuchirawat%2C+Mathuros%3Bda+Silva%2C+Emerson+R%3BSly%2C+Leith%3BSly%2C+Peter+D%3BStein%2C+Renato+T%3Bvan+den+Berg%2C+Martin%3BZar%2C+Heather%3BLandrigan%2C+Philip+J&rft.aulast=Suk&rft.aufirst=William&rft.date=2016-03-01&rft.volume=124&rft.issue=3&rft.spage=A41&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1510517 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Am Coll Cardiol. 2000 Dec;36(7):2348-50 [11127483] Public Health Rep. 2000 Nov-Dec;115(6):521-9 [11354334] Environ Health Perspect. 2002 May;110(5):487-500 [12003752] Environ Health Perspect. 2002 Jun;110(6):563-9 [12055046] Pediatrics. 2002 Aug;110(2 Pt 1):315-22 [12165584] Environ Health Perspect. 2003 Aug;111(10):1340-7 [12896856] Br Med Bull. 2003;68:1-24 [14757707] N Engl J Med. 2004 Sep 9;351(11):1057-67 [15356303] Int J Epidemiol. 2004 Oct;33(5):1132-7 [15218010] J Am Acad Child Psychiatry. 1982 Mar;21(2):144-52 [7069080] Annu Rev Public Health. 1981;2:277-98 [7348554] N Engl J Med. 1996 Sep 12;335(11):783-9 [8703183] Environ Health Perspect. 1998 Jun;106 Suppl 3:875-80 [9646051] J Am Coll Nutr. 2004 Dec;23(6 Suppl):588S-595S [15640511] MMWR Morb Mortal Wkly Rep. 2006 Jan 6;54(51):1301-5 [16397457] Diabetes Care. 2007 Mar;30(3):622-8 [17327331] JAMA. 2008 Sep 17;300(11):1303-10 [18799442] Environ Toxicol Chem. 2013 Jan;32(1):32-48 [23136056] Lancet Oncol. 2013 Apr;14(4):287-8 [23499544] ILAR J. 2012;53(3-4):289-305 [23744968] PLoS One. 2013;8(9):e72788 [24023773] Vital Health Stat 3. 2012 Nov;(35):1-58 [24252609] Lancet Neurol. 2014 Mar;13(3):330-8 [24556010] MMWR Surveill Summ. 2014 Mar 28;63(2):1-21 [24670961] Endocr Rev. 2014 Aug;35(4):557-601 [24483949] Hormones (Athens). 2010 Jul-Sep;9(3):206-17 [20688618] Sci Am. 2010 Nov;303(5):92 [21033292] Environ Health Perspect. 2011 Mar;119(3):319-25 [21362590] Health Aff (Millwood). 2011 May;30(5):863-70 [21543421] Health Aff (Millwood). 2011 May;30(5):842-50 [21543423] Environ Health Perspect. 2011 Aug;119(8):1189-95 [21507776] Environ Health Perspect. 2011 Aug;119(8):1196-201 [21507777] Environ Health Perspect. 2012 Jan;120(1):38-43 [22222676] Environ Int. 2012 Apr;40:170-8 [21835469] JAMA. 2012 Sep 19;308(11):1113-21 [22990270] Environ Health Perspect. 2012 Oct;120(10):1353-61 [22672778] Environ Health Perspect. 2012 Nov;120(11):1527-31 [22949133] Mt Sinai J Med. 2012 Nov-Dec;79(6):632-40 [23239202] Lancet. 2012 Dec 15;380(9859):2055-8 [23245598] Lancet. 2012 Dec 15;380(9859):2095-128 [23245604] Lancet. 2012 Dec 15;380(9859):2224-60 [23245609] Lancet Glob Health. 2013 Dec;1(6):e350-61 [25104600] Lancet Glob Health. 2014 Mar;2(3):e129-30 [25102838] Environ Health Perspect. 2014 Sep;122(9):906-11 [24911630] Int J Hyg Environ Health. 2014 Nov;217(8):819-29 [24948353] Sci Total Environ. 2014 Nov 1;497-498:97-105 [25127444] Am J Epidemiol. 2014 Nov 15;180(10):968-77 [25324558] Ann Glob Health. 2014 Jul-Aug;80(4):257-62 [25459326] Ann Glob Health. 2014 Jul-Aug;80(4):286-95 [25459330] Environ Health Perspect. 2015 Mar;123(3):201-9 [25499717] World Hosp Health Serv. 2014;50(4):35-40 [25985560] JAMA. 2015 Jun 16;313(23):2319-20 [25996138] Lancet. 2015 Oct 10;386(10002):1429-31 [26466029] Lancet. 2015 Nov 28;386(10009):2145-91 [26321261] CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30 [26742998] Environ Health Perspect. 2016 May;124(5):550-5 [26418733] Environ Int. 2009 Aug;35(6):971-86 [19375165] Environ Health Perspect. 2009 Dec;117(12):1945-52 [20049216] Environ Health Perspect. 2010 Apr;118(4):565-71 [20106747] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1510517 ER - TY - GEN T1 - Response to "Comment on 'Effects of in Utero Exposure to Arsenic during the Second Half of Gestation on Reproductive End Points and Metabolic Parameters in Female CD-1 Mice'". AN - 1770221336; 26930461 JF - Environmental health perspectives AU - Rodriguez, Karina F AU - Ungewitter, Erica K AU - Crespo-Mejias, Yasmin AU - Liu, Chang AU - Nicol, Barbara AU - Kissling, Grace E AU - Yao, Humphrey Hung-Chang Y1 - 2016/03// PY - 2016 DA - March 2016 SP - A46 EP - A47 VL - 124 IS - 3 KW - Arsenites KW - 0 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Animals KW - Mice KW - Female KW - Prenatal Exposure Delayed Effects KW - Reproduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770221336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Environmental+health+perspectives&rft.atitle=Response+to+%22Comment+on+%27Effects+of+in+Utero+Exposure+to+Arsenic+during+the+Second+Half+of+Gestation+on+Reproductive+End+Points+and+Metabolic+Parameters+in+Female+CD-1+Mice%27%22.&rft.au=Rodriguez%2C+Karina+F%3BUngewitter%2C+Erica+K%3BCrespo-Mejias%2C+Yasmin%3BLiu%2C+Chang%3BNicol%2C+Barbara%3BKissling%2C+Grace+E%3BYao%2C+Humphrey+Hung-Chang&rft.aulast=Rodriguez&rft.aufirst=Karina&rft.date=2016-03-01&rft.volume=124&rft.issue=3&rft.spage=A46&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1511181 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-24 N1 - Date created - 2016-03-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neurotoxicol Teratol. 2012 Mar;34(2):221-31 [22266078] Indian J Exp Biol. 2012 Feb;50(2):147-55 [22670478] Toxicol Appl Pharmacol. 2003 Jan 1;186(1):7-17 [12583988] Basic Clin Pharmacol Toxicol. 2011 May;108(5):326-32 [21205216] Int J Toxicol. 2010 May-Jun;29(3):291-6 [20448261] PLoS One. 2012;7(5):e38249 [22693606] Cancer Res. 2006 Feb 1;66(3):1337-45 [16452187] Carcinogenesis. 2004 Jan;25(1):133-41 [14514661] Comment On: Environ Health Perspect. 2016 Mar;124(3):336-43 [26295903] Environ Health Perspect. 2016 Mar;124(3):A46 [26930347] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1511181 ER - TY - GEN T1 - The Value of Alternatives Assessment. AN - 1770221218; 26930551 JF - Environmental health perspectives AU - Weis, Christopher P Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 1 VL - 124 IS - 3 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770221218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Environmental+health+perspectives&rft.atitle=The+Value+of+Alternatives+Assessment.&rft.au=Weis%2C+Christopher+P&rft.aulast=Weis&rft.aufirst=Christopher&rft.date=2016-03-01&rft.volume=124&rft.issue=3&rft.spage=A40&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1611248 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-13 N1 - Date created - 2016-03-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2016 Mar;124(3):265-80 [26339778] Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):194-209 [26348672] Comment On: Environ Health Perspect. 2016 Mar;124(3):265-80 [26339778] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1611248 ER - TY - JOUR T1 - Differential Effects of Silver Nanoparticles and Silver Ions on Tissue Accumulation, Distribution, and Toxicity in the Sprague Dawley Rat Following Daily Oral Gavage Administration for 13 Weeks. AN - 1768556231; 26732888 AB - There are concerns within the regulatory and research communities regarding the health impact associated with consumer exposure to silver nanoparticles (AgNPs). This study evaluated particulate and ionic forms of silver and particle size for differences in silver accumulation, distribution, morphology, and toxicity when administered daily by oral gavage to Sprague Dawley rats for 13 weeks. Test materials and dose formulations were characterized by transmission electron microscopy (TEM), dynamic light scattering, and inductively coupled mass spectrometry (ICP-MS). Seven-week-old rats (10 rats per sex per group) were randomly assigned to treatments: AgNP (10, 75, and 110 nm) at 9, 18, and 36 mg/kg body weight (bw); silver acetate (AgOAc) at 100, 200, and 400 mg/kg bw; and controls (2 mM sodium citrate (CIT) or water). At termination, complete necropsies were conducted, histopathology, hematology, serum chemistry, micronuclei, and reproductive system analyses were performed, and silver accumulations and distributions were determined. Rats exposed to AgNP did not show significant changes in body weights or intakes of feed and water relative to controls, and blood, reproductive system, and genetic tests were similar to controls. Differences in the distributional pattern and morphology of silver deposits were observed by TEM: AgNP appeared predominantly within cells, while AgOAc had an affinity for extracellular membranes. Significant dose-dependent and AgNP size-dependent accumulations were detected in tissues by ICP-MS. In addition, sex differences in silver accumulations were noted for a number of tissues and organs, with accumulations being significantly higher in female rats, especially in the kidney, liver, jejunum, and colon. Published by Oxford University Press on behalf of the Society of Toxicology 2016. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Boudreau, Mary D AU - Imam, Mohammed S AU - Paredes, Angel M AU - Bryant, Matthew S AU - Cunningham, Candice K AU - Felton, Robert P AU - Jones, Margie Y AU - Davis, Kelly J AU - Olson, Greg R AD - Division of Biochemical Toxicology, mary.boudreau@fda.hhs.gov. ; Division of Biochemical Toxicology. ; NCTR-ORA Nanotechnology Core Facility, and. ; Bioinformatics and Biostatistics Division, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas; and. ; Toxicologic Pathology Associates, Jefferson Laboratories, Jefferson, Arkansas. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 131 EP - 160 VL - 150 IS - 1 KW - Ions KW - 0 KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - transmission electron microscopy KW - exposure assessment KW - nanoparticle KW - silver KW - rodent KW - distribution KW - accumulation KW - in vivo KW - silver acetate KW - oral administration KW - Administration, Oral KW - Microscopy, Electron, Transmission KW - Animals KW - Rats, Sprague-Dawley KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Particle Size KW - Spectrophotometry, Atomic KW - Dynamic Light Scattering KW - Tissue Distribution KW - Time Factors KW - Male KW - Female KW - Surface Properties KW - Silver -- pharmacokinetics KW - Metal Nanoparticles -- toxicity KW - Silver -- toxicity KW - Silver -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768556231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Differential+Effects+of+Silver+Nanoparticles+and+Silver+Ions+on+Tissue+Accumulation%2C+Distribution%2C+and+Toxicity+in+the+Sprague+Dawley+Rat+Following+Daily+Oral+Gavage+Administration+for+13+Weeks.&rft.au=Boudreau%2C+Mary+D%3BImam%2C+Mohammed+S%3BParedes%2C+Angel+M%3BBryant%2C+Matthew+S%3BCunningham%2C+Candice+K%3BFelton%2C+Robert+P%3BJones%2C+Margie+Y%3BDavis%2C+Kelly+J%3BOlson%2C+Greg+R&rft.aulast=Boudreau&rft.aufirst=Mary&rft.date=2016-03-01&rft.volume=150&rft.issue=1&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv318 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-02-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv318 ER - TY - JOUR T1 - Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan. AN - 1768556136; 26660633 AB - Tolvaptan, a vasopressin receptor 2 antagonist used to treat hyponatremia, has recently been reported to be associated with liver injury. Sulfotransferases (SULTs) have been implicated as important detoxifying and/or activating enzymes for numerous xenobiotics, drugs, and endogenous compounds. To characterize better the role of SULTs in tolvaptan metabolism, HEK293 cells stably overexpressing 12 human SULTs were generated. Using these cell lines, the extent of tolvaptan sulfate formation was assessed by reversed-phase high-performance liquid chromatography through comparison to a synthetic standard. Of the 12 known human SULTs, no detectable sulfation of tolvaptan was observed with SULT1A1, SULT1A2, SULT1A3, SULT1C2, SULT1C4, SULT4A1, or SULT6B1. The affinity of individual SULT isozymes, as determined by Km analysis, was SULT1C3 >> SULT2A1 > SULT2B1 ∼ SULT1B1 > SULT1E1. The half inhibitory concentration of tolvaptan on cell growth in HEK293/SULT1C3 cells and HEK293/CYP3A4 & SULT1C3 cells was significantly lower than that in the corresponding HEK293/vector cells or HEK293/CYP3A4 & SULT vector cells. Moreover, exposing cells to tolvaptan in the presence of cyclosporine A, an inhibitor of the drug efflux transporters, significantly increased the intracellular levels of tolvaptan sulfate and decreased the cell viability in HEK293/SULT1C3 cells. These data indicate that sulfation increased the cytotoxicity of tolvaptan. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Fang, Jia-Long AU - Wu, Yuanfeng AU - Gamboa da Costa, Gonçalo AU - Chen, Si AU - Chitranshi, Priyanka AU - Beland, Frederick A AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 jia-long.fang@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 27 EP - 39 VL - 150 IS - 1 KW - Antidiuretic Hormone Receptor Antagonists KW - 0 KW - Benzazepines KW - Isoenzymes KW - tolvaptan KW - 21G72T1950 KW - Sulfotransferases KW - EC 2.8.2.- KW - Index Medicus KW - metabolism KW - sulfation KW - cytotoxicity KW - drug efflux transporters KW - Blotting, Western KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Biotransformation KW - Kinetics KW - Humans KW - HEK293 Cells KW - Cell Culture Techniques KW - Chromatography, High Pressure Liquid KW - Sulfotransferases -- genetics KW - Sulfotransferases -- metabolism KW - Benzazepines -- toxicity KW - Antidiuretic Hormone Receptor Antagonists -- metabolism KW - Antidiuretic Hormone Receptor Antagonists -- toxicity KW - Benzazepines -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768556136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Human+Sulfotransferases+Enhance+the+Cytotoxicity+of+Tolvaptan.&rft.au=Fang%2C+Jia-Long%3BWu%2C+Yuanfeng%3BGamboa+da+Costa%2C+Gon%C3%A7alo%3BChen%2C+Si%3BChitranshi%2C+Priyanka%3BBeland%2C+Frederick+A&rft.aulast=Fang&rft.aufirst=Jia-Long&rft.date=2016-03-01&rft.volume=150&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv311 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-02-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv311 ER - TY - JOUR T1 - Discovery of Transcriptional Targets Regulated by Nuclear Receptors Using a Probabilistic Graphical Model. AN - 1768555674; 26643261 AB - Nuclear receptors (NRs) are ligand-activated transcriptional regulators that play vital roles in key biological processes such as growth, differentiation, metabolism, reproduction, and morphogenesis. Disruption of NRs can result in adverse health effects such as NR-mediated endocrine disruption. A comprehensive understanding of core transcriptional targets regulated by NRs helps to elucidate their key biological processes in both toxicological and therapeutic aspects. In this study, we applied a probabilistic graphical model to identify the transcriptional targets of NRs and the biological processes they govern. The Tox21 program profiled a collection of approximate 10 000 environmental chemicals and drugs against a panel of human NRs in a quantitative high-throughput screening format for their NR disruption potential. The Japanese Toxicogenomics Project, one of the most comprehensive efforts in the field of toxicogenomics, generated large-scale gene expression profiles on the effect of 131 compounds (in its first phase of study) at various doses, and different durations, and their combinations. We applied author-topic model to these 2 toxicological datasets, which consists of 11 NRs run in either agonist and/or antagonist mode (18 assays total) and 203 in vitro human gene expression profiles connected by 52 shared drugs. As a result, a set of clusters (topics), which consists of a set of NRs and their associated target genes were determined. Various transcriptional targets of the NRs were identified by assays run in either agonist or antagonist mode. Our results were validated by functional analysis and compared with TRANSFAC data. In summary, our approach resulted in effective identification of associated/affected NRs and their target genes, providing biologically meaningful hypothesis embedded in their relationships. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Lee, Mikyung AU - Huang, Ruili AU - Tong, Weida AD - *NIH/National Center for Advancing Translational Sciences, Rockville, Maryland 20850 and. ; FDA/National Center for Toxicological Research, Jefferson, Arkansas 72079 Weida.tong@fda.hhs.gov. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 64 EP - 73 VL - 150 IS - 1 KW - Endocrine Disruptors KW - 0 KW - Receptors, Cytoplasmic and Nuclear KW - Index Medicus KW - integrative analysis KW - transcriptional regulation KW - toxicogenomics project KW - Tox21 KW - nuclear receptor KW - author-topic model KW - Endocrine Disruptors -- toxicity KW - Datasets as Topic KW - Humans KW - Computer Graphics KW - Models, Statistical KW - Receptors, Cytoplasmic and Nuclear -- antagonists & inhibitors KW - Receptors, Cytoplasmic and Nuclear -- agonists KW - Gene Expression Profiling KW - Toxicogenetics -- statistics & numerical data KW - Transcription, Genetic -- drug effects KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Toxicogenetics -- methods KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768555674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Discovery+of+Transcriptional+Targets+Regulated+by+Nuclear+Receptors+Using+a+Probabilistic+Graphical+Model.&rft.au=Lee%2C+Mikyung%3BHuang%2C+Ruili%3BTong%2C+Weida&rft.aulast=Lee&rft.aufirst=Mikyung&rft.date=2016-03-01&rft.volume=150&rft.issue=1&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv261 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-02-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv261 ER - TY - JOUR T1 - Comparison of methods for auto-coding causation of injury narratives AN - 1765945582; PQ0002578052 AB - Manually reading free-text narratives in large databases to identify the cause of an injury can be very time consuming and recently, there has been much work in automating this process. In particular, the variations of the naive Bayes model have been used to successfully auto-code free text narratives describing the event/exposure leading to the injury of a workers' compensation claim. This paper compares the naive Bayes model with an alternative logistic model and found that this new model outperformed the naive Bayesian model. Further modest improvements were found through the addition of sequences of keywords in the models as opposed to consideration of only single keywords. The programs and weights used in this paper are available upon request to researchers without a training set wishing to automatically assign event codes to large data-sets of text narratives. The utility of sharing this program was tested on an outside set of injury narratives provided by the Bureau of Labor Statistics with promising results. JF - Accident Analysis & Prevention AU - Bertke, S J AU - Meyers, A R AU - Wurzelbacher, S J AU - Measure, A AU - Lampl, M P AU - Robins, D AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Industrywide Studies Branch, 1090 Tusculum Ave, Cincinnati, OH 45226, United States Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 117 EP - 123 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 88 SN - 0001-4575, 0001-4575 KW - Health & Safety Science Abstracts KW - Auto-coding KW - Naive Bayes KW - Regularized logistic regression KW - Injury narratives KW - Workers' compensation KW - Accidents KW - Prevention KW - Injuries KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765945582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accident+Analysis+%26+Prevention&rft.atitle=Comparison+of+methods+for+auto-coding+causation+of+injury+narratives&rft.au=Bertke%2C+S+J%3BMeyers%2C+A+R%3BWurzelbacher%2C+S+J%3BMeasure%2C+A%3BLampl%2C+M+P%3BRobins%2C+D&rft.aulast=Bertke&rft.aufirst=S&rft.date=2016-03-01&rft.volume=88&rft.issue=&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Accident+Analysis+%26+Prevention&rft.issn=00014575&rft_id=info:doi/10.1016%2Fj.aap.2015.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Prevention; Accidents; Injuries; Occupational safety DO - http://dx.doi.org/10.1016/j.aap.2015.12.006 ER - TY - JOUR T1 - Role of silver nanoparticles (AgNPs) on the cardiovascular system. AN - 1765919471; 25543135 AB - With the advent of nanotechnology, the use and applications of silver nanoparticles (AgNPs) have increased, both in consumer products as well as in medical devices. However, little is known about the effects of these nanoparticles on human health, more specific in the cardiovascular system, since this system represents an important route of action in terms of distribution, bioaccumulation and bioavailability of the different circulating substances in the bloodstream. A collection of studies have addressed the effects and applications of different kinds of AgNPs (shaped, sized, coated and functionalized) in several components of the cardiovascular system, such as endothelial cells, isolated vessels and organs as well as integrative animal models, trying to identify the underlying mechanisms involved in their actions, to understand their implication in the field of biomedicine. The purpose of the present review is to summarize the most relevant studies to date of AgNPs effects in the cardiovascular system and provide a broader picture of the potential toxic effects and exposure risks, which in turn will allow pointing out the directions of further research as well as new applications of these versatile nanomaterials. JF - Archives of toxicology AU - Gonzalez, Carmen AU - Rosas-Hernandez, Hector AU - Ramirez-Lee, Manuel Alejandro AU - Salazar-García, Samuel AU - Ali, Syed F AD - Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava Num. 6, Col. Universitaria, 78210, San Luis Potosi, SLP, Mexico. cgonzalez.uaslp@gmail.com. ; Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava Num. 6, Col. Universitaria, 78210, San Luis Potosi, SLP, Mexico. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 493 EP - 511 VL - 90 IS - 3 KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - Cardiovascular system KW - Blood vessels KW - Silver nanoparticles KW - Endothelium KW - Toxicity KW - Endothelium, Vascular -- drug effects KW - Humans KW - Blood Vessels -- drug effects KW - Tissue Distribution KW - Silver -- pharmacology KW - Silver -- pharmacokinetics KW - Metal Nanoparticles -- toxicity KW - Silver -- toxicity KW - Metal Nanoparticles -- adverse effects KW - Cardiovascular System -- drug effects KW - Cardiovascular Diseases -- chemically induced KW - Cardiovascular Diseases -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765919471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Role+of+silver+nanoparticles+%28AgNPs%29+on+the+cardiovascular+system.&rft.au=Gonzalez%2C+Carmen%3BRosas-Hernandez%2C+Hector%3BRamirez-Lee%2C+Manuel+Alejandro%3BSalazar-Garc%C3%ADa%2C+Samuel%3BAli%2C+Syed+F&rft.aulast=Gonzalez&rft.aufirst=Carmen&rft.date=2016-03-01&rft.volume=90&rft.issue=3&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-014-1447-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-14 N1 - Date created - 2016-02-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00204-014-1447-8 ER - TY - JOUR T1 - Delayed entry into HIV medical care in a nationally representative sample of HIV-infected adults receiving medical care in the USA AN - 1765527415 AB - Before widespread antiretroviral therapy (ART), an estimated 17% of people delayed HIV care. We report national estimates of the prevalence and factors associated with delayed care entry in the contemporary ART era. We used Medical Monitoring Project data collected from June 2009 through May 2011 for 1425 persons diagnosed with HIV from May 2004 to April 2009 who initiated care within 12 months. We defined delayed care as entry >three months from diagnosis. Adjusted prevalence ratios (aPRs) were calculated to identify risk factors associated with delayed care. In this nationally representative sample of HIV-infected adults receiving medical care, 7.0% (95% confidence interval [CI]: 5.3-8.8) delayed care after diagnosis. Black race was associated with a lower likelihood of delay than white race (aPR 0.38). Men who have sex with women versus women who have sex with men (aPR 1.86) and persons required to take an HIV test versus recommended by a provider (aPR 2.52) were more likely to delay. Among those who delayed 48% reported a personal factor as the primary reason. Among persons initially diagnosed with HIV (non-AIDS), those who delayed care were twice as likely (aPR 2.08) to develop AIDS as of May 2011. Compared to the pre-ART era, there was a nearly 60% reduction in delayed care entry. Although relatively few HIV patients delayed care entry, certain groups may have an increased risk. Focus on linkage to care among persons who are required to take an HIV test may further reduce delayed care entry. JF - AIDS Care AU - Robertson, McKaylee AU - Wei, Stanley C AU - Beer, Linda AU - Adedinsewo, Demilade AU - Stockwell, Sandra AU - Dombrowski, Julia C AU - Johnson, Christopher AU - Skarbinski, Jacek AD - Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA ; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA; US Public Health Service, Atlanta, GA, USA ; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA ; Department of Medicine, University of Washington, Seattle, WA, USA; Public Health: Seattle & King County HIV/STD Program, Seattle, WA, USA ; Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2016/03// PY - 2016 DA - Mar 2016 SP - 325 EP - 333 CY - London PB - Taylor & Francis Ltd. VL - 28 IS - 3 SN - 0954-0121 KW - Medical Sciences--Psychiatry And Neurology KW - Linkage to care KW - HIV care continuum KW - HIV/AIDS KW - HIV testing KW - initiation of care KW - Art therapy KW - Contemporary art KW - Health care KW - HIV KW - Delayed KW - Antiretroviral therapy KW - Risk factors KW - AIDS KW - Diagnosis KW - Patient care KW - Race UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765527415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+Care&rft.atitle=Delayed+entry+into+HIV+medical+care+in+a+nationally+representative+sample+of+HIV-infected+adults+receiving+medical+care+in+the+USA&rft.au=Robertson%2C+McKaylee%3BWei%2C+Stanley+C%3BBeer%2C+Linda%3BAdedinsewo%2C+Demilade%3BStockwell%2C+Sandra%3BDombrowski%2C+Julia+C%3BJohnson%2C+Christopher%3BSkarbinski%2C+Jacek&rft.aulast=Robertson&rft.aufirst=McKaylee&rft.date=2016-03-01&rft.volume=28&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=AIDS+Care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2015.1096891 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - This work was authored as part of the Contributor's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law. N1 - Last updated - 2017-02-06 DO - http://dx.doi.org/10.1080/09540121.2015.1096891 ER - TY - JOUR T1 - Mutation analysis with random DNA identifiers (MARDI) catalogs Pig-a mutations in heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats. AN - 1765114303; 26683280 AB - Identification of mutations induced by xenotoxins is a common task in the field of genetic toxicology. Mutations are often detected by clonally expanding potential mutant cells and genotyping each viable clone by Sanger sequencing. Such a "clone-by-clone" approach requires significant time and effort, and sometimes is even impossible to implement. Alternative techniques for efficient mutation identification would greatly benefit both basic and regulatory genetic toxicology research. Here, we report the development of Mutation Analysis with Random DNA Identifiers (MARDI), a novel high-fidelity Next Generation Sequencing (NGS) approach that circumvents clonal expansion and directly catalogs mutations in pools of mutant cells. MARDI uses oligonucleotides carrying Random DNA Identifiers (RDIs) to tag progenitor DNA molecules before PCR amplification, enabling clustering of descendant DNA molecules and eliminating NGS- and PCR-induced sequencing artifacts. When applied to the Pig-a cDNA analysis of heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats, MARDI detected nearly all Pig-a mutations that were previously identified by conventional clone-by-clone analysis and discovered many additional ones consistent with DMBA exposure: mostly A to T transversions, with the mutated A located on the non-transcribed DNA strand. © 2015 Wiley Periodicals, Inc. JF - Environmental and molecular mutagenesis AU - Revollo, Javier R AU - Crabtree, Nathaniel M AU - Pearce, Mason G AU - Pacheco-Martinez, M Monserrat AU - Dobrovolsky, Vasily N AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas. ; UALR/UAMS Joint Bioinformatics Program, University of Arkansas at Little Rock, Little Rock, Arkansas. ; Departamento De Ciencias De La Salud, Universidad Autónoma Metropolitana Iztapalapa, Mexico City, Mexico. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 114 EP - 124 VL - 57 IS - 2 KW - Antigens, CD KW - 0 KW - CD48 Antigen KW - Cd48 protein, rat KW - 9,10-Dimethyl-1,2-benzanthracene KW - 57-97-6 KW - Index Medicus KW - cell sorting KW - NGS KW - flow cytometry KW - glycosylphosphatidylinositol (GPI) anchor KW - Animals KW - Rats, Inbred F344 KW - High-Throughput Nucleotide Sequencing -- methods KW - Polymerase Chain Reaction -- methods KW - Antigens, CD -- metabolism KW - Antigens, CD -- genetics KW - Male KW - 9,10-Dimethyl-1,2-benzanthracene -- toxicity KW - DNA Mutational Analysis -- methods KW - T-Lymphocytes -- drug effects KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765114303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Mutation+analysis+with+random+DNA+identifiers+%28MARDI%29+catalogs+Pig-a+mutations+in+heterogeneous+pools+of+CD48-deficient+T+cells+derived+from+DMBA-treated+rats.&rft.au=Revollo%2C+Javier+R%3BCrabtree%2C+Nathaniel+M%3BPearce%2C+Mason+G%3BPacheco-Martinez%2C+M+Monserrat%3BDobrovolsky%2C+Vasily+N&rft.aulast=Revollo&rft.aufirst=Javier&rft.date=2016-03-01&rft.volume=57&rft.issue=2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.21992 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-17 N1 - Date created - 2016-02-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/em.21992 ER - TY - JOUR T1 - HESI/FDA workshop on immunomodulators and cancer risk assessment: Building blocks for a weight-of-evidence approach. AN - 1762959849; 26743742 AB - Profound immunosuppression (e.g., AIDS, transplant therapy) is epidemiologically associated with an increased cancer risk, and often with oncogenic viruses. It is currently unclear how broadly this association translates to therapeutics that modulate immunity. A workshop co-sponsored by the FDA and HESI examined how perturbing the immune system may contribute to carcinogenesis, and highlighted priorities for improving non-clinical risk assessment of targeted immunomodulatory therapies. Conclusions from the workshop were as follows. 1) While profound altered immunity can promote tumorigenesis, not all components of the immune system are equally important in defense against or promotion of cancer and a similar cancer risk for all immunomodulatory molecules should not be assumed. 2) Rodent carcinogenicity studies have limitations and are generally not reliable predictors of cancer risk associated with immunosuppression. 3) Cancer risk needs to be evaluated based on mechanism-based weight-of-evidence, including data from immune function tests most relevant to tumor immunosurveillance or promotion. 4) Information from nonclinical experiments, clinical epidemiology and immunomodulatory therapeutics show that immunosurveillance involves a complex network of cells and mediators. To support a weight-of-evidence approach, an increased focus on understanding the quantitative relationship between changes in relevant immune function tests and cancer risk is needed. Copyright © 2015. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Lebrec, H AU - Brennan, F R AU - Haggerty, H AU - Herzyk, D AU - Kamperschroer, C AU - Maier, C C AU - Ponce, R AU - Preston, B D AU - Weinstock, D AU - Mellon, R D AD - Amgen Inc, 1120 Veterans Blvd, South San Francisco, CA 94080, USA. Electronic address: hlebrec@amgen.com. ; UCB-Celltech, 208 Bath Road, Slough SL1 3WE, UK. ; Bristol-Myers Squibb Company, 1 Squibb Dr., New Brunswick, NJ 08903, USA. ; Merck & Co Inc, 770 Sumneytown Pike, PO Box 4, MS WP45-233, West Point, PA, USA. ; Pfizer Inc, Eastern Point Rd, Groton, CT 063340, USA. ; GlaxoSmithKline, 709 Swedeland Rd, King of Prussia, PA 19406, USA. ; Amgen Inc, 1120 Veterans Blvd, South San Francisco, CA 94080, USA. ; Janssen Research & Development, LLC, Welsh & McKean Roads, Spring House, PA 19477, USA. ; Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Y1 - 2016/03// PY - 2016 DA - March 2016 SP - 72 EP - 80 VL - 75 KW - Immunologic Factors KW - 0 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Risk assessment KW - Immunotoxicology KW - Immunotoxicity KW - Carcinogenicity KW - Immunomodulation KW - Cancer KW - Immunosuppression KW - Animals KW - Humans KW - Tumor Necrosis Factor-alpha -- immunology KW - Tumor Necrosis Factor-alpha -- antagonists & inhibitors KW - Risk Assessment -- legislation & jurisprudence KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Neoplasms -- immunology KW - Immunologic Factors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762959849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=HESI%2FFDA+workshop+on+immunomodulators+and+cancer+risk+assessment%3A+Building+blocks+for+a+weight-of-evidence+approach.&rft.au=Lebrec%2C+H%3BBrennan%2C+F+R%3BHaggerty%2C+H%3BHerzyk%2C+D%3BKamperschroer%2C+C%3BMaier%2C+C+C%3BPonce%2C+R%3BPreston%2C+B+D%3BWeinstock%2C+D%3BMellon%2C+R+D&rft.aulast=Lebrec&rft.aufirst=H&rft.date=2016-03-01&rft.volume=75&rft.issue=&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.12.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-02 N1 - Date created - 2016-02-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.12.018 ER - TY - JOUR T1 - A novel ultra-performance liquid chromatography hyphenated with quadrupole time of flight mass spectrometry method for rapid estimation of total toxic retronecine-type of pyrrolizidine alkaloids in herbs without requiring corresponding standards. AN - 1722928003; 26471688 AB - Nearly 50% of naturally-occurring pyrrolizidine alkaloids (PAs) are hepatotoxic, and the majority of hepatotoxic PAs are retronecine-type PAs (RET-PAs). However, quantitative measurement of PAs in herbs/foodstuffs is often difficult because most of reference PAs are unavailable. In this study, a rapid, selective, and sensitive UHPLC-QTOF-MS method was developed for the estimation of RET-PAs in herbs without requiring corresponding standards. This method is based on our previously established characteristic and diagnostic mass fragmentation patterns and the use of retrorsine for calibration. The use of a single RET-PA (i.e. retrorsine) for construction of calibration was based on high similarities with no significant differences demonstrated by the calibration curves constructed by peak areas of extract ion chromatograms of fragment ion at m/z 120.0813 or 138.0919 versus concentrations of five representative RET-PAs. The developed method was successfully applied to measure a total content of toxic RET-PAs of diversified structures in fifteen potential PA-containing herbs. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Food chemistry AU - Zhu, Lin AU - Ruan, Jian-Qing AU - Li, Na AU - Fu, Peter P AU - Ye, Yang AU - Lin, Ge AD - School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; The Chinese University of Hong Kong - Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines, China. ; State Key Lab for Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau, China. ; National Center for Toxicological Research, Jefferson, AR 72079, United States. ; The Chinese University of Hong Kong - Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines, China; State Key Laboratory of Drug Research & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China. ; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; The Chinese University of Hong Kong - Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines, China. Electronic address: gelin@cuhk.edu.hk. Y1 - 2016/03/01/ PY - 2016 DA - 2016 Mar 01 SP - 1320 EP - 1328 VL - 194 SN - 0308-8146, 0308-8146 KW - Drugs, Chinese Herbal KW - 0 KW - Pyrrolizidine Alkaloids KW - retronecine KW - 2P5723M6II KW - Index Medicus KW - Retronecine type KW - Pyrrolizidine alkaloids KW - Hepatotoxic KW - Food safety KW - UHPLC–MS KW - Drugs, Chinese Herbal -- analysis KW - Drugs, Chinese Herbal -- toxicity KW - Chromatography, High Pressure Liquid -- methods KW - Pyrrolizidine Alkaloids -- analysis KW - Mass Spectrometry -- methods KW - Asteraceae -- toxicity KW - Asteraceae -- chemistry KW - Pyrrolizidine Alkaloids -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722928003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+chemistry&rft.atitle=A+novel+ultra-performance+liquid+chromatography+hyphenated+with+quadrupole+time+of+flight+mass+spectrometry+method+for+rapid+estimation+of+total+toxic+retronecine-type+of+pyrrolizidine+alkaloids+in+herbs+without+requiring+corresponding+standards.&rft.au=Zhu%2C+Lin%3BRuan%2C+Jian-Qing%3BLi%2C+Na%3BFu%2C+Peter+P%3BYe%2C+Yang%3BLin%2C+Ge&rft.aulast=Zhu&rft.aufirst=Lin&rft.date=2016-03-01&rft.volume=194&rft.issue=&rft.spage=1320&rft.isbn=&rft.btitle=&rft.title=Food+chemistry&rft.issn=03088146&rft_id=info:doi/10.1016%2Fj.foodchem.2014.11.093 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-31 N1 - Date created - 2015-10-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.foodchem.2014.11.093 ER - TY - JOUR T1 - Lanostane-type triterpenes from the fungal endophyte Scleroderma UFSMSc1 (Persoon) Fries AN - 1790962753; PQ0003039276 AB - Two lanostane triterpenoids (sclerodols A and B) were isolated from the culture of the Eucalyptus grandis derived from the endophyte Scleroderma UFSM Sc1(Persoon) Fries together with three known compounds: one related triterpenoid lanosta-8,23-dien-3 beta ,25-diol, the disaccharide alpha , beta -trehalose, and the sugar alcohol mannitol. Their structures were elucidated on the basis of 2D NMR, HRME, and single-crystal X-ray diffraction data. The methanol crude extract and the isolated lanostane triterpenoids showed promising anticandidal activities. Sclerodols A and B, two anticandidal lanostane triterpenoids, were isolated from the culture of the Eucalyptus grandis-derived from the fungal endophyte Scleroderma UFSMSc1 (Persoon) Fries, together with the known triterpenoid lanosta-8,23-dien-3 beta ,25-diol. JF - Bioorganic and Medicinal Chemistry Letters AU - Morandini, Liziane MB AU - Neto, Alexandre T AU - Pedroso, Marcelo AU - Antoniolli, Zaida I AU - Burrow, Robert A AU - Bortoluzzi, Adailton J AU - Mostardeiro, Marco A AU - Silva, Ubiratan Fda AU - Dalcol, Ionara I AU - Morel, Ademir F Y1 - 2016/02/15/ PY - 2016 DA - 2016 Feb 15 SP - 1173 EP - 1176 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 26 IS - 4 SN - 0960-894X, 0960-894X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Scleroderma UFSMSc1 (Persoon) Fries KW - Fungal endophyte KW - Lanostenoids KW - Anticandidal activity KW - triterpenoids KW - Sugar KW - Data processing KW - Endophytes KW - Methanol KW - X-ray diffraction KW - Eucalyptus KW - Disaccharides KW - Mannitol KW - Eucalyptus grandis KW - alcohols KW - Scleroderma KW - N.M.R. KW - triterpenes KW - K 03340:Effects of Physical & Chemical Factors KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790962753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Lanostane-type+triterpenes+from+the+fungal+endophyte+Scleroderma+UFSMSc1+%28Persoon%29+Fries&rft.au=Morandini%2C+Liziane+MB%3BNeto%2C+Alexandre+T%3BPedroso%2C+Marcelo%3BAntoniolli%2C+Zaida+I%3BBurrow%2C+Robert+A%3BBortoluzzi%2C+Adailton+J%3BMostardeiro%2C+Marco+A%3BSilva%2C+Ubiratan+Fda%3BDalcol%2C+Ionara+I%3BMorel%2C+Ademir+F&rft.aulast=Morandini&rft.aufirst=Liziane&rft.date=2016-02-15&rft.volume=26&rft.issue=4&rft.spage=1173&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2016.01.044 L2 - http://www.sciencedirect.com/science/article/pii/S0960894X16300440 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Sugar; triterpenoids; Data processing; Mannitol; Endophytes; Methanol; alcohols; Scleroderma; triterpenes; N.M.R.; X-ray diffraction; Disaccharides; Eucalyptus grandis; Eucalyptus DO - http://dx.doi.org/10.1016/j.bmcl.2016.01.044 ER - TY - JOUR T1 - Tracing Origins of the Salmonella Bareilly Strain Causing a Food-borne Outbreak in the United States AN - 1780506182; PQ0002864475 AB - Background. Using a novel combination of whole-genome sequencing (WGS) analysis and geographic metadata, we traced the origins of Salmonella Bareilly isolates collected in 2012 during a widespread food-borne outbreak in the United States associated with scraped tuna imported from India. Methods. Using next-generation sequencing, we sequenced the complete genome of 100 Salmonella Bareilly isolates obtained from patients who consumed contaminated product, from natural sources, and from unrelated historically and geographically disparate foods. Pathogen genomes were linked to geography by projecting the phylogeny on a virtual globe and produced a transmission network. Results. Phylogenetic analysis of WGS data revealed a common origin for outbreak strains, indicating that patients in Maryland and New York were infected from sources originating at a facility in India. Conclusions. These data represent the first report fully integrating WGS analysis with geographic mapping and a novel use of transmission networks. Results showed that WGS vastly improves our ability to delimit the scope and source of bacterial food-borne contamination events. Furthermore, these findings reinforce the extraordinary utility that WGS brings to global outbreak investigation as a greatly enhanced approach to protecting the human food supply chain as well as public health in general. JF - Journal of Infectious Diseases AU - Hoffmann, Maria AU - Luo, Yan AU - Monday, Steven R AU - Gonzalez-Escalona, Narjol AU - Ottesen, Andrea R AU - Muruvanda, Tim AU - Wang, Charles AU - Kastanis, George AU - Keys, Christine AU - Janies, Daniel AD - Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Nutrition, maria.hoffman@fda.hhs.gov Y1 - 2016/02/15/ PY - 2016 DA - 2016 Feb 15 SP - 502 EP - 508 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 213 IS - 4 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - salmonellosis KW - geographic information systems KW - next generation sequencing KW - single nucleotide polymorphism KW - traceback KW - Genomes KW - Thunnus KW - Historical account KW - Food chains KW - Food KW - India KW - Disease transmission KW - Public health KW - Infectious diseases KW - Mapping KW - Geography KW - Phylogeny KW - Food supply KW - Data processing KW - Pathogens KW - Food contamination KW - ANW, USA, Maryland KW - ANW, USA, New York KW - Outbreaks KW - Salmonella KW - Gene mapping KW - J 02310:Genetics & Taxonomy KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780506182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Tracing+Origins+of+the+Salmonella+Bareilly+Strain+Causing+a+Food-borne+Outbreak+in+the+United+States&rft.au=Hoffmann%2C+Maria%3BLuo%2C+Yan%3BMonday%2C+Steven+R%3BGonzalez-Escalona%2C+Narjol%3BOttesen%2C+Andrea+R%3BMuruvanda%2C+Tim%3BWang%2C+Charles%3BKastanis%2C+George%3BKeys%2C+Christine%3BJanies%2C+Daniel&rft.aulast=Hoffmann&rft.aufirst=Maria&rft.date=2016-02-15&rft.volume=213&rft.issue=4&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiv297 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Phylogeny; Genomes; Food chains; Data processing; Food; Pathogens; Geography; Food contamination; Gene mapping; Public health; Disease transmission; Historical account; Food supply; Infectious diseases; Mapping; Outbreaks; Thunnus; Salmonella; ANW, USA, New York; ANW, USA, Maryland; India DO - http://dx.doi.org/10.1093/infdis/jiv297 ER - TY - JOUR T1 - Assessing arsenic exposure in households using bottled water or point-of-use treatment systems to mitigate well water contamination. AN - 1764342257; 26674699 AB - There is little published literature on the efficacy of strategies to reduce exposure to residential well water arsenic. The objectives of our study were to: 1) determine if water arsenic remained a significant exposure source in households using bottled water or point-of-use treatment systems; and 2) evaluate the major sources and routes of any remaining arsenic exposure. We conducted a cross-sectional study of 167 households in Maine using one of these two strategies to prevent exposure to arsenic. Most households included one adult and at least one child. Untreated well water arsenic concentrations ranged from <10 μg/L to 640 μg/L. Urine samples, water samples, daily diet and bathing diaries, and household dietary and water use habit surveys were collected. Generalized estimating equations were used to model the relationship between urinary arsenic and untreated well water arsenic concentration, while accounting for documented consumption of untreated water and dietary sources. If mitigation strategies were fully effective, there should be no relationship between urinary arsenic and well water arsenic. To the contrary, we found that untreated arsenic water concentration remained a significant (p ≤ 0.001) predictor of urinary arsenic levels. When untreated water arsenic concentrations were <40 μg/L, untreated water arsenic was no longer a significant predictor of urinary arsenic. Time spent bathing (alone or in combination with water arsenic concentration) was not associated with urinary arsenic. A predictive analysis of the average study participant suggested that when untreated water arsenic ranged from 100 to 500 μg/L, elimination of any untreated water use would result in an 8%-32% reduction in urinary arsenic for young children, and a 14%-59% reduction for adults. These results demonstrate the importance of complying with a point-of-use or bottled water exposure reduction strategy. However, there remained unexplained, water-related routes of exposure. Copyright © 2015 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Smith, Andrew E AU - Lincoln, Rebecca A AU - Paulu, Chris AU - Simones, Thomas L AU - Caldwell, Kathleen L AU - Jones, Robert L AU - Backer, Lorraine C AD - Maine Department of Health and Human Services, Maine Center for Disease Control and Prevention, 286 Water Street, Augusta, ME 04333, USA. Electronic address: Andy.E.Smith@maine.gov. ; Maine Department of Health and Human Services, Maine Center for Disease Control and Prevention, 286 Water Street, Augusta, ME 04333, USA. ; Maine Department of Health and Human Services, Maine Center for Disease Control and Prevention, 286 Water Street, Augusta, ME 04333, USA; University of Southern Maine, Muskie School of Public Service, PO Box 9300, Portland, ME 04104-9300, USA. ; Centers for Disease Control and Prevention, National Center for Environmental Health, Inorganic and Radiation Analytical Toxicology Branch, 4770 Buford Highway NE, MS F-18, Chamblee, GA 30341, USA. ; Centers for Disease Control and Prevention, National Center for Environmental Health, Health Studies Branch, 4770 Buford Highway NE, MS F-60, Chamblee, GA 30341, USA. Y1 - 2016/02/15/ PY - 2016 DA - 2016 Feb 15 SP - 701 EP - 710 VL - 544 KW - Drinking Water KW - 0 KW - Water Pollutants, Chemical KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Bottled water KW - Bathing KW - Well water KW - Point-of-use KW - Children KW - Family Characteristics KW - Environmental Monitoring KW - Humans KW - Water Purification KW - Maine KW - Arsenic -- analysis KW - Water Wells KW - Water Pollutants, Chemical -- analysis KW - Environmental Exposure -- statistics & numerical data KW - Drinking Water -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1764342257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Assessing+arsenic+exposure+in+households+using+bottled+water+or+point-of-use+treatment+systems+to+mitigate+well+water+contamination.&rft.au=Smith%2C+Andrew+E%3BLincoln%2C+Rebecca+A%3BPaulu%2C+Chris%3BSimones%2C+Thomas+L%3BCaldwell%2C+Kathleen+L%3BJones%2C+Robert+L%3BBacker%2C+Lorraine+C&rft.aulast=Smith&rft.aufirst=Andrew&rft.date=2016-02-15&rft.volume=544&rft.issue=&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.11.136 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-02 N1 - Date created - 2016-02-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Res. 2011 Jan;111(1):110-8 [21093857] Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20656-60 [22143778] J Contam Hydrol. 2008 Jul 29;99(1-4):8-21 [18571283] J Health Popul Nutr. 2006 Sep;24(3):298-304 [17366771] Environ Health Perspect. 2005 Feb;113(2):192-200 [15687057] J Nutr. 1994 Nov;124(11 Suppl):2245S-2317S [7965210] Am J Epidemiol. 1991 Nov 15;134(10):1233-44 [1746532] Environ Sci Technol. 2003 May 15;37(10):2075-83 [12785510] Toxicol Lett. 2002 Jul 7;133(1):77-82 [12076512] Stat Med. 2000 Dec 15;19(23):3171-91 [11113952] Sci Total Environ. 2015 Feb 1;505:1282-90 [24726512] Sci Total Environ. 2015 Feb 1;505:1274-81 [24875279] J Expo Sci Environ Epidemiol. 2014 Mar-Apr;24(2):156-62 [23860400] Anal Bioanal Chem. 2009 Feb;393(3):939-47 [19082583] J Expo Sci Environ Epidemiol. 2012 Mar-Apr;22(2):182-90 [21878987] Environ Health Perspect. 2012 Oct;120(10):1418-24 [23008276] Environ Health Perspect. 2013 Mar;121(3):295-302 [23458756] J Expo Sci Environ Epidemiol. 2013 Jul;23(4):442-9 [23321855] Environ Health Perspect. 2013 Jul;121(7):818-24 [23694900] Sci Total Environ. 2015 Feb 1;505:1361-9 [24975493] PLoS One. 2014;9(9):e108098 [25251890] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.11.136 ER - TY - JOUR T1 - Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice. AN - 1760906318; 26335255 AB - The expression of the tumor suppressor p53 can influence the bioactivation of, and DNA damage induced by, the environmental carcinogen benzo[a]pyrene, indicating a role for p53 in its cytochrome P450 (CYP)-mediated biotransformation. The carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), which is formed during the cooking of food, is also metabolically activated by CYP enzymes, particularly CYP1A2. We investigated the potential role of p53 in PhIP metabolism in vivo by treating Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice with a single oral dose of 50 mg/kg body weight PhIP. N-(Deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP-C8-dG) levels in DNA, measured by liquid chromatography-tandem mass spectrometry, were significantly lower in liver, colon, forestomach and glandular stomach of Trp53(-/-) mice compared to Trp53(+/+) mice. Lower PhIP-DNA adduct levels in the livers of Trp53(-/-) mice correlated with lower Cyp1a2 enzyme activity (measured by methoxyresorufin-O-demethylase activity) in these animals. Interestingly, PhIP-DNA adduct levels were significantly higher in kidney and bladder of Trp53(-/-) mice compared to Trp53(+/+) mice, which was accompanied by higher sulfotransferase (Sult) 1a1 protein levels and increased Sult1a1 enzyme activity (measured by 2-naphthylsulfate formation from 2-naphthol) in kidneys of these animals. Our study demonstrates a role for p53 in the metabolism of PhIP in vivo, extending previous results on a novel role for p53 in xenobiotic metabolism. Our results also indicate that the impact of p53 on PhIP biotransformation is tissue-dependent and that in addition to Cyp1a enzymes, Sult1a1 can contribute to PhIP-DNA adduct formation. © 2015 The Authors International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. JF - International journal of cancer AU - Krais, Annette M AU - Speksnijder, Ewoud N AU - Melis, Joost P M AU - Singh, Rajinder AU - Caldwell, Anna AU - Gamboa da Costa, Gonçalo AU - Luijten, Mirjam AU - Phillips, David H AU - Arlt, Volker M AD - Analytical and Environmental Sciences Division, MRC-PHE Centre for Environment and Health, King's College London, London, SE1 9NH, United Kingdom. ; Center for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, MA, 3721, The Netherlands. ; Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, LE2 7LX, United Kingdom. ; Mass Spectrometry Facility, King's College London, London, SE1 9NH, United Kingdom. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079. Y1 - 2016/02/15/ PY - 2016 DA - 2016 Feb 15 SP - 976 EP - 982 VL - 138 IS - 4 KW - Carcinogens KW - 0 KW - DNA Adducts KW - Imidazoles KW - Tumor Suppressor Protein p53 KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - Index Medicus KW - mass spectrometry KW - sulfotransferases KW - mouse model KW - cytochrome P450 KW - heterocyclic aromatic hydrocarbon KW - PhIP KW - DNA adduct formation KW - tumor suppressor p53 KW - carcinogen metabolism KW - Animals KW - Blotting, Western KW - Mice, Inbred C57BL KW - Chromatography, Liquid KW - Mice KW - Tandem Mass Spectrometry KW - Male KW - Mice, Knockout KW - Imidazoles -- toxicity KW - Carcinogens -- metabolism KW - Imidazoles -- metabolism KW - Activation, Metabolic -- physiology KW - Carcinogens -- toxicity KW - Tumor Suppressor Protein p53 -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - DNA Adducts -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760906318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Metabolic+activation+of+2-amino-1-methyl-6-phenylimidazo+%5B4%2C5-b%5Dpyridine+and+DNA+adduct+formation+depends+on+p53%3A+Studies+in+Trp53%28%2B%2F%2B%29%2CTrp53%28%2B%2F-%29+and+Trp53%28-%2F-%29+mice.&rft.au=Krais%2C+Annette+M%3BSpeksnijder%2C+Ewoud+N%3BMelis%2C+Joost+P+M%3BSingh%2C+Rajinder%3BCaldwell%2C+Anna%3BGamboa+da+Costa%2C+Gon%C3%A7alo%3BLuijten%2C+Mirjam%3BPhillips%2C+David+H%3BArlt%2C+Volker+M&rft.aulast=Krais&rft.aufirst=Annette&rft.date=2016-02-15&rft.volume=138&rft.issue=4&rft.spage=976&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.29836 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-31 N1 - Date created - 2016-01-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2000 Sep;28(9):1063-8 [10950850] Arch Toxicol. 2016 Apr;90(4):839-51 [25995008] Mutat Res. 2002 Sep 30;506-507:91-9 [12351148] Food Chem Toxicol. 2002 Oct;40(10):1529-33 [12387319] Curr Biol. 1994 Jan 1;4(1):1-7 [7922305] Cancer Epidemiol Biomarkers Prev. 1999 Jun;8(6):507-12 [10385140] Toxicol Sci. 2006 Oct;93(2):242-55 [16807285] Carcinogenesis. 2008 Jan;29(1):202-10 [17942461] Carcinogenesis. 2008 Mar;29(3):656-65 [18204078] J Pathol. 2010 Jan;220(2):164-73 [19918835] J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Aug 1;878(23):2155-62 [20598652] Chem Res Toxicol. 2010 Jul 19;23(7):1192-201 [20545351] Prostate. 2010 Oct 1;70(14):1586-99 [20687231] Mutat Res. 2011 Feb 28;720(1-2):34-41 [21167309] Carcinogenesis. 2011 Nov;32(11):1734-40 [21900212] Drug Metab Dispos. 2011 Dec;39(12):2169-73 [21940903] Environ Mol Mutagen. 2012 Apr;53(3):207-17 [22351035] Carcinogenesis. 2013 Jan;34(1):190-8 [23054612] Mol Pharmacol. 2014 Jun;85(6):887-97 [24682467] Hum Mutat. 2014 Jun;35(6):715-27 [24415648] Carcinogenesis. 2014 Oct;35(10):2339-45 [25053625] Arch Toxicol. 2016 Feb;90(2):291-304 [25398514] Toxicol Pathol. 2001;29 Suppl:155-60 [11695552] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ijc.29836 ER - TY - JOUR T1 - Distribution of Dengue Virus Types 1 and 4 in Blood Components from Infected Blood Donors from Puerto Rico AN - 1773850672; PQ0002734068 AB - Dengue is a febrile disease caused by the four dengue viruses (DENV-1 to 4) transmitted by mosquitoes from the genus Aedes that can also be transmitted by blood transfusion and organ transplantation. DENV is present in the blood of infected individuals without symptoms, meaning that infected donors may pose a risk to the safety of the donor blood supply. Current methods for detecting transfusion-transmitted viruses by nucleic acid testing use plasma as the testing specimen, and the number of tests that can be performed without reducing availability of blood for transfusion is limited. To determine whether blood components other than plasma could be suitable for testing, we quantified and compared the concentrations of DENV RNA in the residual components of blood collected from subjects previously identified as infected in a parallel blood safety study. Additionally, when available, samples were also evaluated for infectivity in tissue culture. The results showed that DENV RNA and infectious virions were detected comparably in all blood components, suggesting that using alternate specimens may improve sample availability but may not improve testing sensitivity. JF - PLoS Neglected Tropical Diseases AU - Anez, German AU - Heisey, Daniel AR AU - Chancey, Caren AU - Fares, Rafaelle CG AU - Espina, Luz M AU - Souza, Katia PR AU - Teixeira-Carvalho, Andrea AU - Krysztof, David E AU - Foster, Gregory A AU - Stramer, Susan L AU - Rios, Maria AD - U.S. Food and Drug Administration, Silver Spring, Maryland, United States of America Y1 - 2016/02/12/ PY - 2016 DA - 2016 Feb 12 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 10 IS - 2 SN - 1935-2727, 1935-2727 KW - Entomology Abstracts; Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Dengue virus KW - Virions KW - Sensitivity KW - Blood donors KW - Aedes KW - Transplantation KW - Viruses KW - Safety KW - Tissue culture KW - Transfusion KW - Organs KW - Disease transmission KW - Infectivity KW - Blood transfusion KW - nucleic acids KW - RNA KW - ASW, Caribbean Sea, Greater Antilles, Puerto Rico KW - Dengue KW - Nucleic acids KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - H 13000:Medical Safety KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773850672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Distribution+of+Dengue+Virus+Types+1+and+4+in+Blood+Components+from+Infected+Blood+Donors+from+Puerto+Rico&rft.au=Anez%2C+German%3BHeisey%2C+Daniel+AR%3BChancey%2C+Caren%3BFares%2C+Rafaelle+CG%3BEspina%2C+Luz+M%3BSouza%2C+Katia+PR%3BTeixeira-Carvalho%2C+Andrea%3BKrysztof%2C+David+E%3BFoster%2C+Gregory+A%3BStramer%2C+Susan+L%3BRios%2C+Maria&rft.aulast=Anez&rft.aufirst=German&rft.date=2016-02-12&rft.volume=10&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0004445 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Virions; Blood donors; Infectivity; nucleic acids; Blood transfusion; RNA; Dengue; Tissue culture; Disease transmission; Sensitivity; Transplantation; Safety; Viruses; Transfusion; Organs; Nucleic acids; Dengue virus; Aedes; ASW, Caribbean Sea, Greater Antilles, Puerto Rico DO - http://dx.doi.org/10.1371/journal.pntd.0004445 ER - TY - JOUR T1 - Causal inference with a quantitative exposure AN - 1855340850 AB - Summary The current statistical literature on causal inference is mostly concerned with binary or categorical exposures, even though exposures of a quantitative nature are frequently encountered in epidemiologic research. In this article, we review the available methods for estimating the dose-response curve for a quantitative exposure, which include ordinary regression based on an outcome regression model, inverse propensity weighting and stratification based on a propensity function model, and an augmented inverse propensity weighting method that is doubly robust with respect to the two models. We note that an outcome regression model often imposes an implicit constraint on the dose-response curve, and propose a flexible modeling strategy that avoids constraining the dose-response curve. We also propose two new methods: a weighted regression method that combines ordinary regression with inverse propensity weighting and a stratified regression method that combines ordinary regression with stratification. The proposed methods are similar to the augmented inverse propensity weighting method in the sense of double robustness, but easier to implement and more generally applicable. The methods are illustrated with an obstetric example and compared in simulation studies. JF - Statistical Methods in Medical Research AU - Zhang, Zhiwei AU - Zhou, Jie AU - Cao, Weihua AU - Zhang, Jun AD - Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA ; MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China ; Division of Biostatistics, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2016/02// PY - 2016 DA - Feb 2016 SP - 315 EP - 335 CY - London PB - Sage Publications Ltd. VL - 25 IS - 1 SN - 0962-2802 KW - Medical Sciences KW - Dose-response relationship KW - double robustness KW - inverse probability weighting KW - outcome regression KW - propensity function KW - propensity score KW - stratification KW - Weighting KW - Simulation KW - Stratification KW - Augmentation KW - Robustness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855340850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Causal+inference+with+a+quantitative+exposure&rft.au=Zhang%2C+Zhiwei%3BZhou%2C+Jie%3BCao%2C+Weihua%3BZhang%2C+Jun&rft.aulast=Zhang&rft.aufirst=Zhiwei&rft.date=2016-02-01&rft.volume=25&rft.issue=1&rft.spage=315&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280212452333 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2012 N1 - Last updated - 2017-01-05 DO - http://dx.doi.org/10.1177/0962280212452333 ER - TY - JOUR T1 - Bayesian approach to non-inferiority trials for normal means AN - 1855339261 AB - Regulatory framework recommends that novel statistical methodology for analyzing trial results parallels the frequentist strategy, e.g. the new method must protect type-I error and arrive at a similar conclusion. Keeping these in mind, we construct a Bayesian approach for non-inferiority trials with normal response. A non-informative prior is assumed for the mean response of the experimental treatment and Jeffrey's prior for its corresponding variance when it is unknown. The posteriors of the mean response and variance of the treatment in historical trials are then assumed as priors for its corresponding parameters in the current trial, where that treatment serves as the active control. From these priors, a Bayesian decision criterion is derived to determine whether the experimental treatment is non-inferior to the active control. This criterion is evaluated and compared with the frequentist method using simulation studies. Results show that both Bayesian and frequentist approaches perform alike, but the Bayesian approach has a higher power when the variances are unknown. Both methods also arrive at the same conclusion of non-inferiority when applied on two real datasets. A major advantage of the proposed Bayesian approach lies in its ability to provide posterior probabilities for varying effect sizes of the experimental treatment over the active control. JF - Statistical Methods in Medical Research AU - Gamalo, M Amper AU - Wu, Rui AU - Tiwari, Ram C AD - Office of Biostatistics, Food and Drug Administration, USA ; Department of Statistics, University of Connecticut, USA ; Statistical Science and Policy, Office of Biostatistics, Food and Drug Administration, USA ; Office of Biostatistics, Food and Drug Administration, USA Y1 - 2016/02// PY - 2016 DA - Feb 2016 SP - 221 EP - 240 CY - London PB - Sage Publications Ltd. VL - 25 IS - 1 SN - 0962-2802 KW - Medical Sciences KW - Non-inferiority KW - prior distribution KW - Jeffrey's prior KW - posterior distribution KW - fixed-margin approach KW - Power KW - Bayesian analysis KW - Experimental treatment KW - Parameters KW - Simulation KW - Approaches KW - Inferiority UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855339261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Bayesian+approach+to+non-inferiority+trials+for+normal+means&rft.au=Gamalo%2C+M+Amper%3BWu%2C+Rui%3BTiwari%2C+Ram+C&rft.aulast=Gamalo&rft.aufirst=M&rft.date=2016-02-01&rft.volume=25&rft.issue=1&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280212448723 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2012 N1 - Last updated - 2017-01-05 DO - http://dx.doi.org/10.1177/0962280212448723 ER - TY - JOUR T1 - Comparative Effects of Metal-Catalyzed Oxidizing Systems on Carbonylation and Integrity of Therapeutic Proteins AN - 1837298054; PQ0002587099 AB - Ascorbic acid has been considered as a potential radical scavenging excipient for pharmaceutical formulations. However, under certain circumstances, ascorbic acid can generate reactive oxygen species via redox cycling. The objective of this study was to investigate ascorbic acid-induced oxidative carbonylation of therapeutic proteins and correlate the increase in carbonylation with protein aggregation. An optimized ELISA for quantifying carbonyl levels was used to compare the oxidizing potentials of ascorbic acid and hydrogen peroxide by testing four pharmaceutically-relevant proteins (human serum albumin, immunoglobulin G, granulocyte-colony stimulating factor and calcitonin). Several transition metals at micromolar concentrations were evaluated for their ability to enhance ascorbic acid-induced protein carbonylation. Protein aggregation under oxidative conditions, with or without free radical scavengers, was measured by aggregate binding fluorescent dye and confirmed by microfluidic imaging. Addition of ascorbic acid alone resulted in higher increases in carbonylation than addition of hydrogen peroxide. The presence of trace amounts (>75 ppb) of copper enhanced oxidative effects of ascorbic acid, whereas other tested metals did not comparably promote oxidation. During oxidation, protein destabilization indicated by loss of the full-length protein, positively correlated with the increase in protein aggregation. However, levels of aggregation did not always correlate with the levels of protein carbonylation. At comparable carbonylation levels, addition of copper produced greater protein destabilization and aggregation than addition of iron. The results strongly suggest that ascorbic acid with traces of metals, especially copper, can promote therapeutic protein carbonylation and potentially aggregation. At similar carbonylation levels, some oxidative conditions may lead to greater protein destabilization than others. JF - Pharmaceutical Research AU - Kryndushkin, Dmitry AU - Rao, VAshutosh AD - Laboratory of Applied Biochemistry, Division of Biotechnology Products Research and Review III, Office of Biotechnology Products, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, 20993, USA, ashutosh.rao@fda.hhs.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 526 EP - 539 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 33 IS - 2 SN - 0724-8741, 0724-8741 KW - Toxicology Abstracts KW - Calcitonin KW - Enzyme-linked immunosorbent assay KW - Redox properties KW - Heavy metals KW - Free radicals KW - human serum albumin KW - Transition metals KW - Copper KW - imaging KW - Ascorbic acid KW - Microfluidics KW - Hydrogen peroxide KW - Oxidation KW - Immunoglobulin G KW - Pharmaceuticals KW - Fluorescent indicators KW - Iron KW - carbonyls KW - Protein interaction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837298054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+Research&rft.atitle=Comparative+Effects+of+Metal-Catalyzed+Oxidizing+Systems+on+Carbonylation+and+Integrity+of+Therapeutic+Proteins&rft.au=Kryndushkin%2C+Dmitry%3BRao%2C+VAshutosh&rft.aulast=Kryndushkin&rft.aufirst=Dmitry&rft.date=2016-02-01&rft.volume=33&rft.issue=2&rft.spage=526&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+Research&rft.issn=07248741&rft_id=info:doi/10.1007%2Fs11095-015-1807-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 52 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Calcitonin; Redox properties; Enzyme-linked immunosorbent assay; Heavy metals; Free radicals; human serum albumin; Transition metals; Copper; imaging; Ascorbic acid; Microfluidics; Hydrogen peroxide; Oxidation; Immunoglobulin G; Fluorescent indicators; Pharmaceuticals; carbonyls; Iron; Protein interaction DO - http://dx.doi.org/10.1007/s11095-015-1807-y ER - TY - JOUR T1 - Evaluation of the In Vitro Efficacy of Sevelamer Hydrochloride and Sevelamer Carbonate: Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism AN - 1811902414; PQ0003310987 AB - The objective of this project is to develop an in vitro approach that can be used to determine the phosphate binding capacity of sevelamer hydrochloride and carbonate for both drug products and active pharmaceutical ingredients (APIs). A simple and efficient inductively coupled plasma spectrometer method for analysis of phosphate at physiologically relevant pH conditions has been developed and validated. The method addresses each of the analytical validation characteristics such as linearity, accuracy, precision, stability, and selectivity, and meets the acceptance criteria defined in the United States Food and Drug Administration guidance (Food and Drug Administration, Center for Drug Evaluation and Research. 2001. Guidance for industry-Bioanalytical method validation, May). The in vitro phosphate binding efficacies were systematically evaluated and compared for two drug products and two APIs. The phosphate binding profiles appeared similar between the drug products. Under all conditions, the sevelamer-phosphate binding reached equilibrium at 6 h. The 90% confidence interval for the k2 ratio (sevelamer carbonate vs. sevelamer hydrochloride) was well within 80%-125% under all pH conditions. However, the k1 ratio varied, indicating that there exists difference in the binding affinity. Our findings will be useful in assisting with "in vivo" biowaiver for the approval of generic sevelamer drug products. JF - Journal of Pharmaceutical Sciences AU - Yang, Yongsheng AU - Mohammad, Adil AU - Berendt, Robert T AU - Carlin, Alan AU - Khan, Mansoor A AU - Faustino, Patrick J AD - Division of Product Quality Research, Office of Pharmaceutical Quality, Food and Drug Administration, Life Science Building 64, Silver Spring, Maryland 20993 Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 864 EP - 875 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 105 IS - 2 SN - 0022-3549, 0022-3549 KW - Toxicology Abstracts KW - sevelamer KW - inductively coupled plasma KW - phosphate binding KW - langmuir equation KW - bioequivalence KW - polymeric drugs KW - kinetics KW - absorption KW - drug interaction KW - Phosphate KW - Drug metabolism KW - Pharmaceuticals KW - Drug development KW - carbonates KW - pH effects KW - Pharmacokinetics KW - Pharmacodynamics KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811902414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Evaluation+of+the+In+Vitro+Efficacy+of+Sevelamer+Hydrochloride+and+Sevelamer+Carbonate%3A+Pharmacokinetics%2C+Pharmacodynamics+and+Drug+Transport+and+Metabolism&rft.au=Yang%2C+Yongsheng%3BMohammad%2C+Adil%3BBerendt%2C+Robert+T%3BCarlin%2C+Alan%3BKhan%2C+Mansoor+A%3BFaustino%2C+Patrick+J&rft.aulast=Yang&rft.aufirst=Yongsheng&rft.date=2016-02-01&rft.volume=105&rft.issue=2&rft.spage=864&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24572 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 31 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Phosphate; Drug metabolism; Pharmaceuticals; Drug development; pH effects; carbonates; Pharmacodynamics; Pharmacokinetics DO - http://dx.doi.org/10.1002/jps.24572 ER - TY - JOUR T1 - Meta-analysis using Dirichlet process AN - 1778659949 AB - This article develops a Bayesian approach for meta-analysis using the Dirichlet process. The key aspect of the Dirichlet process in meta-analysis is the ability to assess evidence of statistical heterogeneity or variation in the underlying effects across study while relaxing the distributional assumptions. We assume that the study effects are generated from a Dirichlet process. Under a Dirichlet process model, the study effects parameters have support on a discrete space and enable borrowing of information across studies while facilitating clustering among studies. We illustrate the proposed method by applying it to a dataset on the Program for International Student Assessment on 30 countries. Results from the data analysis, simulation studies, and the log pseudo-marginal likelihood model selection procedure indicate that the Dirichlet process model performs better than conventional alternative methods. JF - Statistical Methods in Medical Research AU - Muthukumarana, Saman AU - Tiwari, Ram C AD - Department of Statistics, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada ; Office of Biostatistics, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA Y1 - 2016/02// PY - 2016 DA - Feb 2016 SP - 352 EP - 365 CY - London PB - Sage Publications Ltd. VL - 25 IS - 1 SN - 0962-2802 KW - Medical Sciences KW - Clustering KW - heterogeneity KW - log pseudo-marginal likelihood KW - Markov chain Monte Carlo KW - odds ratio KW - Analysis KW - Bayesian analysis KW - Heterogeneity KW - Marginal KW - Parameters KW - Simulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1778659949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Meta-analysis+using+Dirichlet+process&rft.au=Muthukumarana%2C+Saman%3BTiwari%2C+Ram+C&rft.aulast=Muthukumarana&rft.aufirst=Saman&rft.date=2016-02-01&rft.volume=25&rft.issue=1&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280212453891 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2012 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1177/0962280212453891 ER - TY - JOUR T1 - Diffuse Interface Methods for Modeling Drug-Eluting Stent Coatings AN - 1776665431; PQ0002814729 AB - An overview of diffuse interface models specific to drug-eluting stent coatings is presented. Microscale heterogeneities, both in the coating and use environment, dictate the performance of these coatings. Using diffuse interface methods, these heterogeneities can be explicitly incorporated into the model equations with relative ease. This enables one to predict the complex microstructures that evolve during coating fabrication and subsequent impact on drug release. Examples are provided that illustrate the wide range of phenomena that can be addressed with diffuse interface models including: crystallization, constrained phase separation, hydrolytic degradation, and heterogeneous binding. Challenges associated with the lack of material property data and numerical solution of the model equations are also highlighted. Finally, in light of these potential drawbacks, the potential to utilize diffuse interface models to help guide product and process development is discussed. JF - Annals of Biomedical Engineering AU - Saylor, David M AU - Forrey, Christopher AU - Kim, Chang-Soo AU - Warren, James A AD - Food and Drug Administration, Silver Spring, MD, 20993, USA, david.saylor@fda.hhs.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 548 EP - 559 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 44 IS - 2 SN - 0090-6964, 0090-6964 KW - Biotechnology and Bioengineering Abstracts KW - Crystallization KW - Drug delivery KW - Mathematical models KW - Data processing KW - Implants KW - Reviews KW - Drugs KW - Models KW - Coatings KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776665431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Diffuse+Interface+Methods+for+Modeling+Drug-Eluting+Stent+Coatings&rft.au=Saylor%2C+David+M%3BForrey%2C+Christopher%3BKim%2C+Chang-Soo%3BWarren%2C+James+A&rft.aulast=Saylor&rft.aufirst=David&rft.date=2016-02-01&rft.volume=44&rft.issue=2&rft.spage=548&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-015-1375-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 44 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Crystallization; Drug delivery; Data processing; Mathematical models; Reviews; Implants; Drugs; Coatings; Models DO - http://dx.doi.org/10.1007/s10439-015-1375-7 ER - TY - JOUR T1 - Serious injury and fatality investigations involving pneumatic nail guns, 1985-2012 AN - 1776645139; PQ0002763858 AB - Background This article examines serious and fatal pneumatic nail gun (PNG) injury investigations for workplace, tool design, and human factors relevant to causation and resulting OS&H authorities' responses in terms of citations and penalties. Methods The U.S. Occupational Safety and Health Administration (OSHA) database of Fatality and Catastrophe Investigation Summaries (F&CIS) were reviewed (1985-2012) to identify n=258 PNG accidents. Results 79.8% of investigations, and 100% of fatalities, occurred in the construction industry. Between 53-71% of injuries appear to have been preventable had a safer sequential trigger tool been used. Citations and monetary penalties were related to injury severity, body part injured, disabling of safety devices, and insufficient personal protective equipment (PPE). Conclusions Differences may exist between construction and other industries in investigators interpretations of PNG injury causation and resulting citations/penalties. Violations of PPE standards were penalized most severely, yet the preventive effect of PPE would likely have been less than that of a safer sequential trigger. Am. J. Ind. Med. 59:164-174, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Lowe, Brian D AU - Albers, James T AU - Hudock, Stephen D AU - Krieg, Edward F AD - National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 164 EP - 174 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 2 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Mortality KW - Federal regulations KW - Safety regulations KW - Injuries KW - Occupational safety KW - Safety KW - Protective equipment KW - USA KW - Accidents KW - Safety engineering KW - Reviews KW - Economics KW - Human factors KW - Construction industry KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776645139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Serious+injury+and+fatality+investigations+involving+pneumatic+nail+guns%2C+1985-2012&rft.au=Lowe%2C+Brian+D%3BAlbers%2C+James+T%3BHudock%2C+Stephen+D%3BKrieg%2C+Edward+F&rft.aulast=Lowe&rft.aufirst=Brian&rft.date=2016-02-01&rft.volume=59&rft.issue=2&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22560 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Mortality; Federal regulations; Safety regulations; Injuries; Safety; Occupational safety; Protective equipment; Accidents; Safety engineering; Reviews; Economics; Human factors; Construction industry; USA DO - http://dx.doi.org/10.1002/ajim.22560 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF A PENTABROMODIPHENYL ETHER MIXTURE [DE-71 (TECHNICAL GRADE)] (CAS NO. 32534-81-9) IN F344/N RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF A PENTABROMODIPHENYL ETHER MIXTURE [DE-71 (TECHNICAL GRADE)] IN WISTAR HAN [Crl:WI(Han)]RATS AND B6C3F1/N MICE (GAVAGE STUDIES) AN - 1774580840 AB - DE-71, a pentabromodiphenyl ether mixture, was used in the past as an additive flame retardant, often in furniture. Here, a study to identify potential toxic or cancer-related hazards of DE-71 on male and female rats and mice is presented. Solutions containing DE-71 in corn oil were deposited through a tube directly into the stomach to groups of 50 male and 50 female rats and mice 5 days per week for 2 years. At the end of the study, tissues from more than 40 sites were examined for every animal. Results revealed that treated male and female rats and mice had liver cancer at the two highest dose levels. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/02// PY - 2016 DA - Feb 2016 SP - 1 EP - 19,21-113,115-129,131-151,153-173,175-191,193-229,231-241,243-281,283-289,291-304 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Pituitary gland KW - Tumors KW - Liver cancer KW - Rodents KW - Animal behavior KW - Carcinogens KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1774580840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+A+PENTABROMODIPHENYL+ETHER+MIXTURE+%5BDE-71+%28TECHNICAL+GRADE%29%5D+%28CAS+NO.+32534-81-9%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+A+PENTABROMODIPHENYL+ETHER+MIXTURE+%5BDE-71+%28TECHNICAL+GRADE%29%5D+IN+WISTAR+HAN+%5BCrl%3AWI%28Han%29%5DRATS+AND+B6C3F1%2FN+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-02-01&rft.volume=&rft.issue=589&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Feb 2016 N1 - Document feature - Illustrations; Tables; References N1 - Last updated - 2016-03-21 ER - TY - RPRT T1 - Table of contents AN - 1774580671 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/02// PY - 2016 DA - Feb 2016 SP - 6 EP - 6,5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1774580671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-02-01&rft.volume=&rft.issue=589&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Feb 2016 N1 - Last updated - 2016-03-21 ER - TY - RPRT T1 - FOREWORD AN - 1774580615 AB - The National Toxicology Program (NTP) is an interagency program within the Public Health Service (PHS) of the Department of Health and Human Services (HHS) and is headquartered at the National Institute of Environmental Health Sciences of the National Institutes of Health (NIEHS/NIH). JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2016/02// PY - 2016 DA - Feb 2016 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Carcinogens KW - Public health KW - Health services KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1774580615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2016-02-01&rft.volume=&rft.issue=589&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Name - Food & Drug Administration--FDA; Department of Health & Human Services N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Feb 2016 N1 - Last updated - 2016-03-21 ER - TY - JOUR T1 - The association between marine bathing and infectious diseases- a review AN - 1773837123; PQ0002731321 AB - Worldwide, infectious diseases represent a leading cause of death and disability. Exposure to the ocean, whether through recreation or occupation, represents a potentially significant, but poorly understood, source of infectious diseases in man. This review describes the potential mechanisms whereby marine bathing could lead to infectious diseases in man. Sources of pathogens in the marine environment are described, including human sewage, animal sources, fellow bathers and indigenous marine organisms. The epidemiological evidence for the association between marine bathing and infectious disease is presented, including a consideration of the differing relationship between faecal indicator bacteria levels and illness at point source compared with non-point source settings. Estimating the burden of infectious disease is reliant on public health surveillance, both formal and informal, which is described from a UK perspective in this review. Potential emerging threats at the marine-human interface are discussed, including infections caused by Shewanella and Vibrio bacteria, and the presence of human pathogens in the marine environment that are resistant to antimicrobials. JF - Journal of the Marine Biological Association of the United Kingdom AU - Young, Nicholas AD - University of Bristol, Bristol, UK, nick.young@phe.gov.uk Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 93 EP - 100 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 96 IS - 1 SN - 0025-3154, 0025-3154 KW - Pollution Abstracts; Ecology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Bathing KW - Infection KW - Toxicity tests KW - Shewanella KW - Public health KW - Infectious diseases KW - Marine environment KW - Disabilities KW - Biological surveys KW - Marine KW - Mortality KW - Fecal coliforms KW - Pathogens KW - Nonpoint pollution KW - Water pollution KW - Antimicrobial agents KW - Vibrio KW - Recreation KW - Sewage KW - Literature reviews KW - Oceans KW - Reviews KW - Marine organisms KW - D 04040:Ecosystem and Ecology Studies KW - Q1 08604:Stock assessment and management KW - P 6000:TOXICOLOGY AND HEALTH KW - O 4060:Pollution - Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773837123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Marine+Biological+Association+of+the+United+Kingdom&rft.atitle=The+association+between+marine+bathing+and+infectious+diseases-+a+review&rft.au=Young%2C+Nicholas&rft.aulast=Young&rft.aufirst=Nicholas&rft.date=2016-02-01&rft.volume=96&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Marine+Biological+Association+of+the+United+Kingdom&rft.issn=00253154&rft_id=info:doi/10.1017%2FS0025315415002003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Number of references - 74 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Biological surveys; Recreation; Literature reviews; Infectious diseases; Bathing; Pathogens; Toxicity tests; Water pollution; Public health; Sewage; Marine environment; Reviews; Oceans; Marine organisms; Infection; Antimicrobial agents; Mortality; Fecal coliforms; Nonpoint pollution; Disabilities; Vibrio; Shewanella; Marine DO - http://dx.doi.org/10.1017/S0025315415002003 ER - TY - JOUR T1 - Target and non-target analysis of migrants from PVC-coated cans using UHPLC-Q-Orbitrap MS: evaluation of long-term migration testing AN - 1773833040; PQ0002714429 AB - A simple, rapid and sensitive method for analyzing multi-target and non-target additives in polyvinyl chloride (PVC) food can coatings using ultra-high-performance liquid chromatography coupled to quadrupole-orbital ion-trap mass spectrometry was developed. This procedure was used to study the behaviour of a cross-linking agent, benzoguanamine (BGA), two slip agents, oleamide and erucamide, and 18 other commonly used plasticisers including phthalates, adipates, sebacates, acetyl tributyl citrate and epoxidised soybean or linseed oils. This optimised method was used to detect these analytes in food simulants (water and 3% acetic acid) in a long-term migration test of PVC-coated food cans for a period ranging from 1 day to 1.5 years at 40 degree C. Although very low detection limits (5 ng ml super(-1)) were obtained for the majority of compounds, none of the monitored plasticisers and slip agents was detected in simulants extracted from cans over the period of the test. However, the presence of BGA in both aqueous food simulants was confirmed based on high-resolution mass spectrometry, product ion spectra and analysis of a reference standard. The BGA concentration in both simulants continued to increase with storage time: after 1.5 years storage in aqueous food simulants at 40 degree C, BGA was detected at concentrations up to 84 mu g dm super(-2). We believe this is the first study describing the long-term migration capacity of BGA from any vinyl coating material intended for use in PVC-coated food cans. Our results may have implications for migration test protocols for food cans that will be stored for extended time periods. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Vaclavikova, Marta AU - Paseiro-Cerrato, Rafael AU - Vaclavik, Lukas AU - Noonan, Gregory O AU - DeVries, Jonathan AU - Begley, Timothy H AD - Center for Food Safety and Applied Nutrition, Office of Regulatory Science, US Food and Drug Administration (USFDA), College Park, MD, USA Y1 - 2016/02/01/ PY - 2016 DA - 2016 Feb 01 SP - 352 EP - 363 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 2 SN - 1944-0049, 1944-0049 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Polyvinyl chloride KW - Mass spectrometry KW - Migration KW - Storage KW - Oil KW - Food additives KW - Phthalates KW - Liquid chromatography KW - Additives KW - Migrants KW - Coatings KW - R2 23060:Medical and environmental health KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773833040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Target+and+non-target+analysis+of+migrants+from+PVC-coated+cans+using+UHPLC-Q-Orbitrap+MS%3A+evaluation+of+long-term+migration+testing&rft.au=Vaclavikova%2C+Marta%3BPaseiro-Cerrato%2C+Rafael%3BVaclavik%2C+Lukas%3BNoonan%2C+Gregory+O%3BDeVries%2C+Jonathan%3BBegley%2C+Timothy+H&rft.aulast=Vaclavikova&rft.aufirst=Marta&rft.date=2016-02-01&rft.volume=33&rft.issue=2&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1128564 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Oil; Risk assessment; Storage; Food additives; Liquid chromatography; Phthalates; Polyvinyl chloride; Mass spectrometry; Additives; Migration; Migrants; Coatings DO - http://dx.doi.org/10.1080/19440049.2015.1128564 ER - TY - JOUR T1 - Analysis of iodine in food samples by inductively coupled plasma-mass spectrometry AN - 1773825387; PQ0002714431 AB - This work shows a method for the determination of iodine in a variety of food samples and reference materials using inductively coupled plasma-mass spectrometry (ICP-MS) following alkaline extraction. Optimisation of the addition of organic carbon showed that a minimum of 3% 2-propanol was necessary for a constant ratio of iodine to internal standard. The limit of quantification (LOQ), calculated as 30 sigma for the method, was 36 ng g super(-1) in solid food samples. For method validation, seven standard reference materials (SRM) and 21 fortified food samples were used. The precision (%RSD) of the measurements was in the 2-7% range. Accuracies for the SRMs were 85-105%, while the fortified food samples showed 81-119% recoveries, including a number of samples fortified at 50% of the LOQ. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Todorov, Todor I AU - Gray, Patrick J AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration (USFDA), College Park, MD, USA Y1 - 2016/02/01/ PY - 2016 DA - 2016 Feb 01 SP - 282 EP - 290 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 2 SN - 1944-0049, 1944-0049 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Food additives KW - Organic carbon KW - Iodine KW - Spectrometry KW - R2 23060:Medical and environmental health KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773825387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Analysis+of+iodine+in+food+samples+by+inductively+coupled+plasma-mass+spectrometry&rft.au=Todorov%2C+Todor+I%3BGray%2C+Patrick+J&rft.aulast=Todorov&rft.aufirst=Todor&rft.date=2016-02-01&rft.volume=33&rft.issue=2&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1131337 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Organic carbon; Iodine; Spectrometry DO - http://dx.doi.org/10.1080/19440049.2015.1131337 ER - TY - JOUR T1 - Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents AN - 1768577854; PQ0002651066 AB - Pulmonary fibrosis results from the excessive deposition of collagen fibers and scarring in the lungs with or without an identifiable cause. The mechanism(s) underlying lung fibrosis development is poorly understood, and effective treatment is lacking. Here we compared mouse lung fibrosis induced by pulmonary exposure to prototypical particulate (crystalline silica) or soluble chemical (bleomycin or paraquat) fibrogenic agents to identify the underlying mechanisms. Young male C57BL/6J mice were given silica (2 mg), bleomycin (0.07 mg), or paraquat (0.02 mg) by pharyngeal aspiration. All treatments induced significant inflammatory infiltration and collagen deposition, manifesting fibrotic foci in silica-exposed lungs or diffuse fibrosis in bleomycin or paraquat-exposed lungs on day 7 post-exposure, at which time the lesions reached their peaks and represented a junction of transition from an acute response to chronic fibrosis. Lung genome-wide gene expression was analyzed, and differential gene expression was confirmed by quantitative RT-PCR, immunohistochemistry, and immunoblotting for representative genes to demonstrate their induced expression and localization in fibrotic lungs. Canonical signaling pathways, gene ontology, and upstream transcription networks modified by each agent were identified. In particular, these inducers elicited marked proliferative responses; at the same time, silica preferentially activated innate immune functions and the defense against foreign bodies, whereas bleomycin and paraquat boosted responses related to cell adhesion, platelet activation, extracellular matrix remodeling, and wound healing. This study identified, for the first time, the shared and unique genes, signaling pathways, and biological functions regulated by particulate and soluble chemical fibrogenic agents during lung fibrosis, providing insights into the mechanisms underlying human lung fibrotic diseases. JF - Archives of Toxicology AU - Dong, Jie AU - Yu, Xiaoqing AU - Porter, Dale W AU - Battelli, Lori A AU - Kashon, Michael L AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Mailstop 3014, 1095 Willowdale Road, Morgantown, WV, 26505, USA, qam1@cdc.gov Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 385 EP - 402 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 90 IS - 2 SN - 0340-5761, 0340-5761 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Pharynx KW - Fibrosis KW - Particulates KW - Cell activation KW - Collagen KW - Gene expression KW - Upstream KW - Lesions KW - Polymerase chain reaction KW - Paraquat KW - Immunoblotting KW - Lung diseases KW - Wound healing KW - Mice KW - Adhesion KW - Bleomycin KW - Cell adhesion KW - Fibers KW - Silica KW - Lung KW - Infiltration KW - Platelets KW - Immune response KW - Foreign bodies KW - Signal transduction KW - H 14000:Toxicology KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768577854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=Common+and+distinct+mechanisms+of+induced+pulmonary+fibrosis+by+particulate+and+soluble+chemical+fibrogenic+agents&rft.au=Dong%2C+Jie%3BYu%2C+Xiaoqing%3BPorter%2C+Dale+W%3BBattelli%2C+Lori+A%3BKashon%2C+Michael+L%3BMa%2C+Qiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2016-02-01&rft.volume=90&rft.issue=2&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-015-1589-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 48 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Immunoblotting; Pharynx; Fibrosis; Lung diseases; Wound healing; Bleomycin; Collagen; Cell activation; Cell adhesion; Gene expression; Fibers; Silica; Lung; Platelets; Polymerase chain reaction; Immune response; Foreign bodies; Paraquat; Signal transduction; Infiltration; Lesions; Upstream; Mice; Particulates; Adhesion DO - http://dx.doi.org/10.1007/s00204-015-1589-3 ER - TY - JOUR T1 - Precision and robustness of 2D-NMR for structure assessment of filgrastim biosimilars AN - 1768572969; PQ0002688268 JF - Nature Biotechnology AU - Ghasriani, Houman AU - Hodgson, Derek J AU - Brinson, Robert G AU - McEwen, Ian AU - Buhse, Lucinda F AU - Kozlowski, Steven AU - Marino, John P AU - Aubin, Yves AU - Keire, David A AD - US Food and Drug Administration, Center for Drug Evaluation and Research, Division of Pharmaceutical Analysis, St. Louis, Missouri, USA. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 139 EP - 141 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 34 IS - 2 SN - 1087-0156, 1087-0156 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768572969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Biotechnology&rft.atitle=Precision+and+robustness+of+2D-NMR+for+structure+assessment+of+filgrastim+biosimilars&rft.au=Ghasriani%2C+Houman%3BHodgson%2C+Derek+J%3BBrinson%2C+Robert+G%3BMcEwen%2C+Ian%3BBuhse%2C+Lucinda+F%3BKozlowski%2C+Steven%3BMarino%2C+John+P%3BAubin%2C+Yves%3BKeire%2C+David+A&rft.aulast=Ghasriani&rft.aufirst=Houman&rft.date=2016-02-01&rft.volume=34&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt.3474 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 DO - http://dx.doi.org/10.1038/nbt.3474 ER - TY - JOUR T1 - Molecular Characterization of Salmonella enterica Serovars Isolated from a Turkey Production Facility in the Absence of Selective Antimicrobial Pressure. AN - 1765116250; 26653998 AB - This study evaluated antimicrobial resistance and virulence factors in Salmonella enterica isolated from a turkey flock in which the birds were raised in an environment where antimicrobials were not administered to the birds, either through feed or water. Salmonella was isolated from turkeys and various environmental samples in the facility using conventional microbiological procedures. Isolates were serotyped and analyzed phenotypically by antimicrobial resistance profiling and genotypically by pulsed-field gel electrophoresis (PFGE) fingerprinting, integron analysis, plasmid profiling, replicon-based incompatibility (Inc) group typing, and virulence gene profiling. Ninety-five S. enterica isolates were isolated from cecal contents (n = 29), feed (n = 22), leftover feed (n = 13), litter (n = 12), drinkers (n = 10), environment (n = 8), and an insect. The following serotypes were identified: Montevideo (24%), Anatum (22%), Agona (17%), Kentucky and Worthington (12%), Senftenberg (11%), and rough phenotypes (3%). The majority of isolates (61/95; 64%) were susceptible to 12 antimicrobials tested; however, despite the absence of antimicrobials in the facility, approximately 36% of the isolates were resistant to two to five antimicrobials. Class 1 integrons were detected in 8% of the isolates. The integron sequence analysis revealed dihydrofolate reductase (dhfr) and aminoglycoside adenylyl transferase (aadA2) genes, which encode trimethoprim and streptomycin resistance, respectively. Furthermore, 71% of the isolates had at least one plasmid. There were five plasmid replicon types identified among the isolates, including IncI1, IncHI2, IncFIIA, IncB/O, and IncP, with variable prevalence among the serotypes. All 95 isolates tested polymerase chain reaction-positive for 19 virulence genes and negative for virD4 and virB4. The virulence gene profiles were similar within the isolates from the same serotype. Within particular serotypes, PFGE patterns revealed 100% similarity, even when the bacterial strains were isolated from different sources, indicating cross-colonization of sources within the turkey facility. On this antibiotic-free turkey farm, turkeys and feed appeared to be the major reservoirs of multidrug-resistant Salmonella, which harbored multiple virulence genes. JF - Foodborne pathogens and disease AU - Sanad, Yasser M AU - Johnson, Kelly AU - Park, Si Hong AU - Han, Jing AU - Deck, Joanna AU - Foley, Steven L AU - Kenney, Brett AU - Ricke, Steven AU - Nayak, Rajesh AD - 1 Division of Microbiology, National Center for Toxicological Research , U.S. Food and Drug Administration, Jefferson, Arkansas. ; 2 Center for Food Safety and Department of Food Science, University of Arkansas , Fayetteville, Arkansas. ; 3 Department of Animal and Nutritional Science, West Virginia University , Morgantown, West Virginia. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 80 EP - 87 VL - 13 IS - 2 KW - Anti-Infective Agents KW - 0 KW - DNA, Bacterial KW - Virulence Factors KW - Index Medicus KW - Environment KW - Animals KW - Plasmids -- genetics KW - Drug Resistance, Multiple, Bacterial -- genetics KW - DNA, Bacterial -- isolation & purification KW - Food-Processing Industry KW - Genotype KW - Anti-Infective Agents -- immunology KW - Food Microbiology KW - Electrophoresis, Gel, Pulsed-Field KW - Replicon -- genetics KW - Cecum -- microbiology KW - Microbial Sensitivity Tests KW - Integrons -- genetics KW - Salmonella enterica -- isolation & purification KW - Turkeys -- microbiology KW - Salmonella enterica -- genetics KW - Drug Resistance, Bacterial -- genetics KW - Serogroup UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765116250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Foodborne+pathogens+and+disease&rft.atitle=Molecular+Characterization+of+Salmonella+enterica+Serovars+Isolated+from+a+Turkey+Production+Facility+in+the+Absence+of+Selective+Antimicrobial+Pressure.&rft.au=Sanad%2C+Yasser+M%3BJohnson%2C+Kelly%3BPark%2C+Si+Hong%3BHan%2C+Jing%3BDeck%2C+Joanna%3BFoley%2C+Steven+L%3BKenney%2C+Brett%3BRicke%2C+Steven%3BNayak%2C+Rajesh&rft.aulast=Sanad&rft.aufirst=Yasser&rft.date=2016-02-01&rft.volume=13&rft.issue=2&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Foodborne+pathogens+and+disease&rft.issn=1556-7125&rft_id=info:doi/10.1089%2Ffpd.2015.2002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-31 N1 - Date created - 2016-02-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1089/fpd.2015.2002 ER - TY - JOUR T1 - Performance characteristics of the AmpliSeq Cancer Hotspot panel v2 in combination with the Ion Torrent Next Generation Sequencing Personal Genome Machine AN - 1762361366; PQ0002518495 AB - Next-Generation Sequencing is a rapidly advancing technology that has research and clinical applications. For many cancers, it is important to know the precise mutation(s) present, as specific mutations could indicate or contra-indicate certain treatments as well as be indicative of prognosis. Using the Ion Torrent Personal Genome Machine and the AmpliSeq Cancer Hotspot panel v2, we sequenced two pancreatic cancer cell lines, BxPC-3 and HPAF-II, alone or in mixtures, to determine the error rate, sensitivity, and reproducibility of this system. The system resulted in coverage averaging 2000 across the various amplicons and was able to reliably and reproducibly identify mutations present at a rate of 5%. Identification of mutations present at a lower rate was possible by altering the parameters by which calls were made, but with an increase in erroneous, low-level calls. The panel was able to identify known mutations in these cell lines that are present in the COSMIC database. In addition, other, novel mutations were also identified that may prove clinically useful. The system was assessed for systematic errors such as homopolymer effects, end of amplicon effects and patterns in NO CALL sequence. Overall, the system is adequate at identifying the known, targeted mutations in the panel. JF - Regulatory Toxicology and Pharmacology AU - Butler, Kimberly S AU - Young, Megan YL AU - Li, Zhihua AU - Elespuru, Rosalie K AU - Wood, Steven C AD - U.S. Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry and Materials Science, 10903 New Hampshire Ave, Silver Spring, MD 20993, United States Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 178 EP - 186 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 74 SN - 0273-2300, 0273-2300 KW - Environment Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Next generation sequencing KW - Cancer Hotspot panel KW - Ion Torrent Personal Genome Machine KW - Mutation detection KW - Systematic error analysis KW - Performance analysis KW - Genomes KW - Sensitivity KW - Hot spots KW - Pancreatic cancer KW - Prognosis KW - Therapeutic applications KW - Cancer KW - Databases KW - Tumor cell lines KW - Vocalization behavior KW - Nitric oxide KW - Mutation KW - Technology KW - H 11000:Diseases/Injuries/Trauma KW - X 24310:Pharmaceuticals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762361366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+Toxicology+and+Pharmacology&rft.atitle=Performance+characteristics+of+the+AmpliSeq+Cancer+Hotspot+panel+v2+in+combination+with+the+Ion+Torrent+Next+Generation+Sequencing+Personal+Genome+Machine&rft.au=Butler%2C+Kimberly+S%3BYoung%2C+Megan+YL%3BLi%2C+Zhihua%3BElespuru%2C+Rosalie+K%3BWood%2C+Steven+C&rft.aulast=Butler&rft.aufirst=Kimberly&rft.date=2016-02-01&rft.volume=74&rft.issue=&rft.spage=178&rft.isbn=&rft.btitle=&rft.title=Regulatory+Toxicology+and+Pharmacology&rft.issn=02732300&rft_id=info:doi/10.1016%2Fj.yrtph.2015.09.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Genomes; Databases; Tumor cell lines; Vocalization behavior; Prognosis; Pancreatic cancer; Therapeutic applications; Nitric oxide; Mutation; Sensitivity; Hot spots; Cancer; Technology DO - http://dx.doi.org/10.1016/j.yrtph.2015.09.011 ER - TY - JOUR T1 - Environmental Chemicals in Urine and Blood: Improving Methods for Creatinine and Lipid Adjustment. AN - 1762342753; 26219104 AB - Investigators measuring exposure biomarkers in urine typically adjust for creatinine to account for dilution-dependent sample variation in urine concentrations. Similarly, it is standard to adjust for serum lipids when measuring lipophilic chemicals in serum. However, there is controversy regarding the best approach, and existing methods may not effectively correct for measurement error. We compared adjustment methods, including novel approaches, using simulated case-control data. Using a directed acyclic graph framework, we defined six causal scenarios for epidemiologic studies of environmental chemicals measured in urine or serum. The scenarios include variables known to influence creatinine (e.g., age and hydration) or serum lipid levels (e.g., body mass index and recent fat intake). Over a range of true effect sizes, we analyzed each scenario using seven adjustment approaches and estimated the corresponding bias and confidence interval coverage across 1,000 simulated studies. For urinary biomarker measurements, our novel method, which incorporates both covariate-adjusted standardization and the inclusion of creatinine as a covariate in the regression model, had low bias and possessed 95% confidence interval coverage of nearly 95% for most simulated scenarios. For serum biomarker measurements, a similar approach involving standardization plus serum lipid level adjustment generally performed well. To control measurement error bias caused by variations in serum lipids or by urinary diluteness, we recommend improved methods for standardizing exposure concentrations across individuals. JF - Environmental health perspectives AU - O'Brien, Katie M AU - Upson, Kristen AU - Cook, Nancy R AU - Weinberg, Clarice R AD - Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 220 EP - 227 VL - 124 IS - 2 KW - Biomarkers KW - 0 KW - Environmental Pollutants KW - Creatinine KW - AYI8EX34EU KW - Index Medicus KW - Regression Analysis KW - Humans KW - Environmental Exposure KW - Case-Control Studies KW - Biomarkers -- urine KW - Creatinine -- urine KW - Environmental Pollutants -- urine KW - Lipid Metabolism KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762342753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Environmental+Chemicals+in+Urine+and+Blood%3A+Improving+Methods+for+Creatinine+and+Lipid+Adjustment.&rft.au=O%27Brien%2C+Katie+M%3BUpson%2C+Kristen%3BCook%2C+Nancy+R%3BWeinberg%2C+Clarice+R&rft.aulast=O%27Brien&rft.aufirst=Katie&rft.date=2016-02-01&rft.volume=124&rft.issue=2&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1509693 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-24 N1 - Date created - 2016-02-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2016 Mar;124(3):321-8 [26161573] N Engl J Med. 1988 Jul 28;319(4):189-94 [3393170] Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495-500 [2505694] Cancer Epidemiol Biomarkers Prev. 1996 Sep;5(9):753-5 [8877068] N Engl J Med. 1997 Oct 30;337(18):1253-8 [9345073] Hum Reprod. 1997 Dec;12(12):2607-13 [9455822] Epidemiology. 1999 Jan;10(1):37-48 [9888278] Environ Health Perspect. 2005 Feb;113(2):192-200 [15687057] Am J Epidemiol. 2005 Apr 15;161(8):714-24 [15800263] Environ Health Perspect. 2005 Jul;113(7):853-7 [16002372] Int J Epidemiol. 2010 Apr;39(2):417-20 [19926667] Epidemiology. 2013 Nov;24(6):921-8 [24051893] Comment In: Environ Health Perspect. 2016 Feb;124(2):A37 [26829818] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1509693 ER - TY - JOUR T1 - The chemopreventive activity of butyrate-containing structured lipids in experimental rat hepatocarcinogenesis. AN - 1762341357; 26548572 AB - Emerging evidence indicates that the use of bioactive food components is a promising strategy to prevent the development of liver cancer. The goal of this study was to examine the chemopreventive effect of butyrate-containing structured lipids (STLs) produced by an enzymatic interesterification of tributyrin and flaxseed oil on rat hepatocarcinogenesis. Male Wistar rats were subjected to a classic "resistant hepatocyte" model of liver carcinogenesis and treated with STLs, tributyrin or flaxseed oil during the initial phases of hepatocarcinogenesis. Treatment with STLs and tributyrin strongly inhibited the development of preneoplastic liver lesions. The chemopreventive activity of tributyrin was associated with the induction of apoptosis and reduction of the expression of major activated hepatocarcinogenesis-related oncogenes. Treatment with STLs caused substantially greater inhibitory effects than tributyrin on oncogene expression. These results demonstrate that the tumor-suppressing activity of butyrate-containing STLs is associated with its ability to prevent and inhibit activation of major hepatocarcinogenesis-related oncogenes. Enrichment of histone H3K9me3 and H3K27me3 at the promoter of Myc and Ccnd1 genes may be related to the inhibitory effect on oncogene expression in the livers of STL-treated rats. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. JF - Molecular nutrition & food research AU - Heidor, Renato AU - de Conti, Aline AU - Ortega, Juliana F AU - Furtado, Kelly S AU - Silva, Roberta C AU - Tavares, Paulo E L M AU - Purgatto, Eduardo AU - Ract, Juliana N R AU - de Paiva, Sérgio A R AU - Gioielli, Luiz A AU - Pogribny, Igor P AU - Moreno, Fernando S AD - Laboratory of Diet, Nutrition and Cancer, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA. ; Department of Biochemical and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. ; Laboratory of Food Chemistry and Biochemistry, Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Brazil. ; Department of Internal Medicine, Botucatu Medical School, UNESP - São Paulo State University, Botucatu, Brazil. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 420 EP - 429 VL - 60 IS - 2 KW - Anticarcinogenic Agents KW - 0 KW - Histones KW - Lipids KW - Triglycerides KW - Butyric Acid KW - 107-92-6 KW - Linseed Oil KW - 8001-26-1 KW - tributyrin KW - S05LZ624MF KW - Index Medicus KW - Rat KW - Tributyrin KW - Liver carcinogenesis KW - Structured lipids KW - Chemoprevention KW - Animals KW - Triglycerides -- pharmacology KW - Linseed Oil -- chemistry KW - Triglycerides -- chemistry KW - Precancerous Conditions -- pathology KW - Precancerous Conditions -- genetics KW - Oncogenes KW - Lipids -- chemistry KW - Histones -- metabolism KW - Precancerous Conditions -- prevention & control KW - Rats, Wistar KW - Lipids -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Histones -- genetics KW - Male KW - Butyric Acid -- pharmacology KW - Liver Neoplasms, Experimental -- pathology KW - Anticarcinogenic Agents -- pharmacology KW - Anticarcinogenic Agents -- chemistry KW - Liver Neoplasms, Experimental -- prevention & control KW - Butyric Acid -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762341357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+nutrition+%26+food+research&rft.atitle=The+chemopreventive+activity+of+butyrate-containing+structured+lipids+in+experimental+rat+hepatocarcinogenesis.&rft.au=Heidor%2C+Renato%3Bde+Conti%2C+Aline%3BOrtega%2C+Juliana+F%3BFurtado%2C+Kelly+S%3BSilva%2C+Roberta+C%3BTavares%2C+Paulo+E+L+M%3BPurgatto%2C+Eduardo%3BRact%2C+Juliana+N+R%3Bde+Paiva%2C+S%C3%A9rgio+A+R%3BGioielli%2C+Luiz+A%3BPogribny%2C+Igor+P%3BMoreno%2C+Fernando+S&rft.aulast=Heidor&rft.aufirst=Renato&rft.date=2016-02-01&rft.volume=60&rft.issue=2&rft.spage=420&rft.isbn=&rft.btitle=&rft.title=Molecular+nutrition+%26+food+research&rft.issn=1613-4133&rft_id=info:doi/10.1002%2Fmnfr.201500643 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-01 N1 - Date created - 2016-02-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/mnfr.201500643 ER - TY - JOUR T1 - MicroRNA Responses to the Genotoxic Carcinogens Aflatoxin B1 and Benzo[a]pyrene in Human HepaRG Cells. AN - 1760921722; 26609139 AB - Recent advances in toxicogenomics present an opportunity to develop new in vitro testing methodologies to identify human carcinogens. We have investigated microRNA expression responses to the treatment of human liver HepaRG cells with the human genotoxic carcinogens aflatoxin B1 (AFB1) and benzo[a]pyrene (B[a]P), and the structurally similar compounds aflatoxin B2 (AFB2) and benzo[e]pyrene (B[e]P) that exhibit minimal carcinogenic potential. We demonstrate that treatment of HepaRG cells with AFB1 or B[a]P resulted in specific changes in the expression of miRNAs as compared with their non-carcinogenic analogues, particularly in a marked over-expression of miR-410. An additional novel finding is the dose- and time-dependent inhibition of miR-122 in AFB1-treated HepaRG cells. Mechanistically, the AFB1-induced down-regulation of miR-122 was attributed to inhibition of the HNF4A/miR-122 regulatory pathway. These results demonstrate that HepaRG cells can be used to investigate miRNA responses to xenobiotic exposure, and illustrate the existence of early non-genotoxic events, in addition to a well-established genotoxic mode of action changes, in the mechanism of AFB1 and B[a]P carcinogenicity. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Marrone, April K AU - Tryndyak, Volodymyr AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079 igor.pogribny@fda.hhs.gov. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 496 EP - 502 VL - 149 IS - 2 KW - Carcinogens KW - 0 KW - HNF4A protein, human KW - Hepatocyte Nuclear Factor 4 KW - MIRN122 microRNA, human KW - MicroRNAs KW - Benzo(a)pyrene KW - 3417WMA06D KW - Aflatoxin B1 KW - 9N2N2Y55MH KW - Index Medicus KW - aflatoxin B1 KW - HepaRG cells KW - microRNA KW - benzo[a]pyrene KW - Hepatocyte Nuclear Factor 4 -- physiology KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Humans KW - Hepatocyte Nuclear Factor 4 -- analysis KW - Benzo(a)pyrene -- toxicity KW - Liver Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Aflatoxin B1 -- toxicity KW - MicroRNAs -- analysis KW - MicroRNAs -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760921722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=MicroRNA+Responses+to+the+Genotoxic+Carcinogens+Aflatoxin+B1+and+Benzo%5Ba%5Dpyrene+in+Human+HepaRG+Cells.&rft.au=Marrone%2C+April+K%3BTryndyak%2C+Volodymyr%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Marrone&rft.aufirst=April&rft.date=2016-02-01&rft.volume=149&rft.issue=2&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv253 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-02 N1 - Date created - 2016-01-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv253 ER - TY - JOUR T1 - Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting. AN - 1760884448; 26479518 AB - This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described using different nomenclature systems. In addition, PGx analysis may detect different sets of variants for each gene, which can affect interpretation of results. This practice has caused confusion and may thereby impede the adoption of clinical PGx testing. Standardization is critical to move PGx forward. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Clinical pharmacology and therapeutics AU - Kalman, L V AU - Agúndez, Jag AU - Appell, M Lindqvist AU - Black, J L AU - Bell, G C AU - Boukouvala, S AU - Bruckner, C AU - Bruford, E AU - Caudle, K AU - Coulthard, S A AU - Daly, A K AU - Del Tredici, Al AU - den Dunnen, J T AU - Drozda, K AU - Everts, R E AU - Flockhart, D AU - Freimuth, R R AU - Gaedigk, A AU - Hachad, H AU - Hartshorne, T AU - Ingelman-Sundberg, M AU - Klein, T E AU - Lauschke, V M AU - Maglott, D R AU - McLeod, H L AU - McMillin, G A AU - Meyer, U A AU - Müller, D J AU - Nickerson, D A AU - Oetting, W S AU - Pacanowski, M AU - Pratt, V M AU - Relling, M V AU - Roberts, A AU - Rubinstein, W S AU - Sangkuhl, K AU - Schwab, M AU - Scott, S A AU - Sim, S C AU - Thirumaran, R K AU - Toji, L H AU - Tyndale, R F AU - van Schaik, Rhn AU - Whirl-Carrillo, M AU - Yeo, Ktj AU - Zanger, U M AD - Centers for Disease Control and Prevention, Atlanta, Georgia, USA. ; Department of Pharmacology, University of Extremadura, Cáceres, Spain. ; Division of Drug Research, Department of Medical and Health Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden. ; Mayo Clinic, Rochester, Minnesota, USA. ; Moffitt Cancer Center, Tampa, Florida, USA. ; Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece. ; Affymetrix, Santa Clara, California, USA. ; HUGO Gene Nomenclature Committee (HGNC), EMBL-EBI, European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton, UK. ; St. Jude Children's Research Hospital, Memphis, Tennessee, USA. ; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK. ; Millennium Health, LLC, San Diego, California, USA. ; Department of Human Genetics and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. ; US Food and Drug Administration, Silver Spring, Maryland, USA. ; Agena Bioscience, San Diego, California, USA. ; Indiana University School of Medicine, Indianapolis, Indiana, USA. ; Division of Clinical Pharmacology and Therapeutic Innovation, Children's Mercy Kansas City and School of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA. ; Translational Software, Bellevue, Washington, USA. ; Department of Genetic Analysis, Thermo Fisher Scientific, South San Francisco, California, USA. ; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. ; Department of Genetics, Stanford University, Stanford, California, USA. ; National Institutes of Health / National Library of Medicine / National Center for Biotechnology Information, Bethesda, Maryland, USA. ; University of Utah and ARUP Laboratories, Salt Lake City, Utah, USA. ; University of Basel, Basel, Switzerland. ; Department of Psychiatry, University of Toronto, CAMH, Toronto, Ontario, Canada. ; Department of Genome Sciences, University of Washington, Seattle, Washington, USA. ; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA. ; Aegis Science Corporation, Nashville, Tennessee, USA. ; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart and Department of Clinical Pharmacology, University Hospital, Tuebingen, Germany. ; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA. ; Genelex Corporation, Seattle, Washington, USA. ; Coriell Institute for Medical Research, Camden, New Jersey, USA. ; CAMH and the Departments of Psychiatry and Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada. ; Department of Clinical Chemistry, Erasmus MC Rotterdam, International Federation for Clinical Chemistry (IFCC) Task Force Pharmacogenetics, Rotterdam, The Netherlands. ; Department of Pathology, The University of Chicago, Chicago, Illinois, USA. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 172 EP - 185 VL - 99 IS - 2 KW - Abridged Index Medicus KW - Index Medicus KW - Genetic Variation KW - Genes KW - Precision Medicine KW - Humans KW - Pharmacogenetics -- standards KW - Alleles KW - Pharmacogenetics -- trends KW - Genetic Testing -- trends KW - Genetic Testing -- standards KW - Terminology as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760884448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Pharmacogenetic+allele+nomenclature%3A+International+workgroup+recommendations+for+test+result+reporting.&rft.au=Kalman%2C+L+V%3BAg%C3%BAndez%2C+Jag%3BAppell%2C+M+Lindqvist%3BBlack%2C+J+L%3BBell%2C+G+C%3BBoukouvala%2C+S%3BBruckner%2C+C%3BBruford%2C+E%3BCaudle%2C+K%3BCoulthard%2C+S+A%3BDaly%2C+A+K%3BDel+Tredici%2C+Al%3Bden+Dunnen%2C+J+T%3BDrozda%2C+K%3BEverts%2C+R+E%3BFlockhart%2C+D%3BFreimuth%2C+R+R%3BGaedigk%2C+A%3BHachad%2C+H%3BHartshorne%2C+T%3BIngelman-Sundberg%2C+M%3BKlein%2C+T+E%3BLauschke%2C+V+M%3BMaglott%2C+D+R%3BMcLeod%2C+H+L%3BMcMillin%2C+G+A%3BMeyer%2C+U+A%3BM%C3%BCller%2C+D+J%3BNickerson%2C+D+A%3BOetting%2C+W+S%3BPacanowski%2C+M%3BPratt%2C+V+M%3BRelling%2C+M+V%3BRoberts%2C+A%3BRubinstein%2C+W+S%3BSangkuhl%2C+K%3BSchwab%2C+M%3BScott%2C+S+A%3BSim%2C+S+C%3BThirumaran%2C+R+K%3BToji%2C+L+H%3BTyndale%2C+R+F%3Bvan+Schaik%2C+Rhn%3BWhirl-Carrillo%2C+M%3BYeo%2C+Ktj%3BZanger%2C+U+M&rft.aulast=Kalman&rft.aufirst=L&rft.date=2016-02-01&rft.volume=99&rft.issue=2&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1002%2Fcpt.280 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-25 N1 - Date created - 2016-01-23 N1 - Date revised - 2017-02-02 N1 - SuppNotes - Cited By: Pharmacogenet Genomics. 2008 Apr;18(4):367-8 [18334921] N Engl J Med. 2008 Feb 7;358(6):568-79 [18256392] Nat Rev Drug Discov. 2008 Oct;7(10):807-17 [18806753] MMWR Recomm Rep. 2009 Jun 12;58(RR-6):1-37; quiz CE-1-4 [19521335] Mt Sinai J Med. 2010 Mar-Apr;77(2):133-9 [20309922] Clin Pharmacol Ther. 2011 Mar;89(3):464-7 [21270786] J Mol Diagn. 2010 Nov;12(6):835-46 [20889555] J Am Pharm Assoc (2003). 2010 Jan-Feb;50(1):e1-14; quiz e15-7 [20368146] Pharmacol Rev. 2011 Mar;63(1):157-81 [21245207] PLoS One. 2011;6(4):e18507 [21494681] Pharmacogenomics. 2012 Jan;13(1):31-41 [22092036] Clin Pharmacol Ther. 2012 Mar;91(3):450-8 [22278335] J Pharm Pract. 2012 Aug;25(4):417-27 [22689709] J Hist Med Allied Sci. 2013 Jan;68(1):1-48 [21908852] Nucleic Acids Res. 2013 Jan;41(Database issue):D925-35 [23193275] Arch Pathol Lab Med. 2013 Sep;137(9):1232-6 [23991737] Genet Med. 2013 Sep;15(9):733-47 [23887774] Int Rev Psychiatry. 2013 Oct;25(5):554-71 [24151801] Clin Pharmacol Ther. 2013 Dec;94(6):640-5 [23988873] Hum Mol Genet. 2014 Apr 15;23(8):1957-63 [24282029] Pharmacogenomics. 2014 Jun;15(9):1223-34 [25141897] Annu Rev Genomics Hum Genet. 2014;15:349-70 [24898040] Eur J Cancer. 2014 Oct;50(15):2532-43 [25103456] Annu Rev Pharmacol Toxicol. 2015;55:89-106 [25292429] Nucleic Acids Res. 2015 Jan;43(Database issue):D1079-85 [25361968] Drug Metab Dispos. 2015 Mar;43(3):400-10 [25519488] Clin Pharmacol Ther. 2015 Mar;97(3):263-73 [25669658] Genet Med. 2015 May;17(5):405-24 [25741868] Pharmacogenomics J. 2015 Jun;15(3):201-10 [25707393] Genet Res (Camb). 2015;97:e13 [26030725] Clin Chem Lab Med. 2015 Jun;53(7):981-8 [25995323] J Mol Diagn. 2016 Jan;18(1):109-23 [26621101] Drug Metab Dispos. 2001 Apr;29(4 Pt 2):591-5 [11259358] Genet Med. 2001 Mar-Apr;3(2):149-54 [11280952] Pharmacogenetics. 2003 Aug;13(8):481-94 [12893986] Genet Med. 2004 Sep-Oct;6(5):387-91 [15371902] Nat Rev Genet. 2004 Sep;5(9):669-76 [15372089] N Engl J Med. 2005 Jun 2;352(22):2285-93 [15930419] Thromb Haemost. 2005 Oct;94(4):773-9 [16270629] Clin Pharmacol Ther. 2007 Sep;82(3):244-8 [17700589] PLoS Med. 2007 Aug;4(8):e209 [17696640] Hum Mutat. 2008 Jan;29(1):6-13 [18000842] Clin Pharmacol Ther. 2008 Sep;84(3):287-94 [18714314] N1 - Last updated - 2017-02-02 DO - http://dx.doi.org/10.1002/cpt.280 ER - TY - JOUR T1 - Windows of sensitivity to toxic chemicals in the motor effects development. AN - 1760864238; 26686904 AB - Many chemicals currently used are known to elicit nervous system effects. In addition, approximately 2000 new chemicals introduced annually have not yet undergone neurotoxicity testing. This review concentrated on motor development effects associated with exposure to environmental neurotoxicants to help identify critical windows of exposure and begin to assess data needs based on a subset of chemicals thoroughly reviewed by the Agency for Toxic Substances and Disease Registry (ATSDR) in Toxicological Profiles and Addenda. Multiple windows of sensitivity were identified that differed based on the maturity level of the neurological system at the time of exposure, as well as dose and exposure duration. Similar but distinct windows were found for both motor activity (GD 8-17 [rats], GD 12-14 and PND 3-10 [mice]) and motor function performance (insufficient data for rats, GD 12-17 [mice]). Identifying specific windows of sensitivity in animal studies was hampered by study designs oriented towards detection of neurotoxicity that occurred at any time throughout the developmental process. In conclusion, while this investigation identified some critical exposure windows for motor development effects, it demonstrates a need for more acute duration exposure studies based on neurodevelopmental windows, particularly during the exposure periods identified in this review. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Ingber, Susan Z AU - Pohl, Hana R AD - Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA. ; Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA. Electronic address: hpohl@cdc.gov. Y1 - 2016/02// PY - 2016 DA - February 2016 SP - 93 EP - 104 VL - 74 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Chemical exposures KW - Laboratory animals KW - Windows of sensitivity KW - Motor development KW - Models, Animal KW - Animals KW - Age Factors KW - Dose-Response Relationship, Drug KW - Humans KW - Gestational Age KW - Mice KW - Risk Assessment KW - Pregnancy KW - Rats KW - Animals, Newborn KW - Morphogenesis -- drug effects KW - Time Factors KW - Species Specificity KW - Female KW - Behavior, Animal -- drug effects KW - Central Nervous System -- embryology KW - Environmental Pollutants -- toxicity KW - Central Nervous System -- physiopathology KW - Neurotoxicity Syndromes -- etiology KW - Central Nervous System -- drug effects KW - Toxicity Tests -- methods KW - Neurotoxicity Syndromes -- physiopathology KW - Neurotoxicity Syndromes -- embryology KW - Motor Activity -- drug effects KW - Motor Neurons -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760864238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Windows+of+sensitivity+to+toxic+chemicals+in+the+motor+effects+development.&rft.au=Ingber%2C+Susan+Z%3BPohl%2C+Hana+R&rft.aulast=Ingber&rft.aufirst=Susan&rft.date=2016-02-01&rft.volume=74&rft.issue=&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.11.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-21 N1 - Date created - 2016-01-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.11.018 ER - TY - JOUR T1 - LY2603618, a selective CHK1 inhibitor, enhances the anti-tumor effect of gemcitabine in xenograft tumor models AN - 1758092722 AB - Summary Pharmacological inhibition of CHK1 in the absence of p53 functionality leads to abrogation of the S and G2/M DNA damage checkpoints. We report the preclinical therapeutic activity of LY2603618 (CHK1 inhibitor) at inhibiting CHK1 activation by gemcitabine and enhancing in vivo efficacy. The in vivo biochemical effects of CHK1 inhibition in the absence or presence of DNA damage were measured in human tumor xenograft models. Colon, lung and pancreatic xenografts models were treated with gemcitabine, LY2603618, or gemcitabine plus LY2603618. Gemcitabine treatment alone induced a significant increase in CHK1 autophosphorylation over untreated tumors. Co-administration of LY2603618 with gemcitabine showed a clear inhibition of CHK1 autophosphorylation for at least 24 h. Combining LY2603618 with gemcitabine resulted in an increase in H2AX serine 139 phosphorylation, indicating a corresponding increase in damaged DNA in the tumors. LY2603618 abrogated the S-phase DNA damage checkpoint in Calu-6 xenograft tumors treated with gemcitabine but did not significantly alter the G2/M checkpoint. Combining gemcitabine with LY2603618 resulted in a significant increase in tumor growth inhibition in Calu-6, HT-29 and PAXF 1869 xenografts over gemcitabine treatment alone. The best combination efficacy occurred when LY2603618 was given 24 h following dosing with gemcitabine. LY2603618 worked effectively to remove the S-phase DNA damage checkpoint and increase the DNA damage and the antitumor activity of gemcitabine treatment. JF - Investigational New Drugs AU - Barnard, Darlene AU - Diaz, H Bruce AU - Burke, Teresa AU - Donoho, Gregory AU - Beckmann, Richard AU - Jones, Bonita AU - Barda, David AU - King, Constance AU - Marshall, Mark Y1 - 2016/02// PY - 2016 DA - Feb 2016 SP - 49 EP - 60 CY - New York PB - Springer Science & Business Media VL - 34 IS - 1 SN - 01676997 KW - Pharmacy And Pharmacology KW - LY2603618 KW - CHK1 KW - DNA-damage KW - Gemcitabine KW - Xenograft KW - Studies KW - Research & development--R&D KW - Pharmaceuticals KW - Tumors KW - Cancer KW - Oncology KW - Drug therapy KW - Clinical trials KW - 8641:Pharmaceuticals industry KW - 9130:Experimental/theoretical KW - 5400:Research & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758092722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+New+Drugs&rft.atitle=LY2603618%2C+a+selective+CHK1+inhibitor%2C+enhances+the+anti-tumor+effect+of+gemcitabine+in+xenograft+tumor+models&rft.au=Barnard%2C+Darlene%3BDiaz%2C+H+Bruce%3BBurke%2C+Teresa%3BDonoho%2C+Gregory%3BBeckmann%2C+Richard%3BJones%2C+Bonita%3BBarda%2C+David%3BKing%2C+Constance%3BMarshall%2C+Mark&rft.aulast=Barnard&rft.aufirst=Darlene&rft.date=2016-02-01&rft.volume=34&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Investigational+New+Drugs&rft.issn=01676997&rft_id=info:doi/10.1007%2Fs10637-015-0310-y LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media New York 2016 N1 - Document feature - References; Tables N1 - Last updated - 2016-02-03 N1 - CODEN - INNDDK DO - http://dx.doi.org/10.1007/s10637-015-0310-y ER - TY - JOUR T1 - Photobacterium angustum and Photobacterium kishitanii, Psychrotrophic High-Level Histamine-Producing Bacteria Indigenous to Tuna. AN - 1775382519; 26826233 AB - Scombrotoxin fish poisoning (SFP) remains the main contributor of fish poisoning incidents in the United States, despite efforts to control its spread. Psychrotrophic histamine-producing bacteria (HPB) indigenous to scombrotoxin-forming fish may contribute to the incidence of SFP. We examined the gills, skin, and anal vents of yellowfin (n = 3), skipjack (n = 1), and albacore (n = 6) tuna for the presence of indigenous HPB. Thirteen HPB strains were isolated from the anal vent samples from albacore (n = 3) and yellowfin (n = 2) tuna. Four of these isolates were identified as Photobacterium kishitanii and nine isolates as Photobacterium angustum; these isolates produced 560 to 603 and 1,582 to 2,338 ppm histamine in marine broth containing 1% histidine (25°C for 48 h), respectively. The optimum growth temperatures and salt concentrations were 26 to 27°C and 1% salt for P. kishitanii and 30 to 32°C and 2% salt for P. angustum in Luria 70% seawater (LSW-70). The optimum activity of the HDC enzyme was at 15 to 30°C for both species. At 5°C, P. kishitanii and P. angustum had growth rates of 0.1 and 0.2 h(-1), respectively, and the activities of histidine decarboxylase (HDC) enzymes were 71% and 63%, respectively. These results show that indigenous HPB in tuna are capable of growing at elevated and refrigeration temperatures. These findings demonstrate the need to examine the relationships between the rate of histamine production at refrigeration temperatures, seafood shelf life, and regulatory limits. Copyright © 2016, American Society for Microbiology. All Rights Reserved. JF - Applied and environmental microbiology AU - Bjornsdottir-Butler, K AU - McCarthy, S A AU - Dunlap, P V AU - Benner, R A AD - FDA, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama, USA kristin.butler@fda.hhs.gov. ; FDA, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama, USA. ; Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, Michigan, USA. Y1 - 2016/01/29/ PY - 2016 DA - 2016 Jan 29 SP - 2167 EP - 2176 VL - 82 IS - 7 KW - Bacterial Proteins KW - 0 KW - Marine Toxins KW - scombrotoxin KW - 82027-58-5 KW - Histamine KW - 820484N8I3 KW - Histidine Decarboxylase KW - EC 4.1.1.22 KW - Index Medicus KW - Phylogeny KW - Animals KW - Histidine Decarboxylase -- genetics KW - Bacterial Proteins -- genetics KW - Histidine Decarboxylase -- metabolism KW - Bacterial Proteins -- metabolism KW - Foodborne Diseases -- microbiology KW - Food Contamination KW - Marine Toxins -- metabolism KW - Marine Toxins -- toxicity KW - Tuna -- microbiology KW - Histamine -- toxicity KW - Photobacterium -- genetics KW - Photobacterium -- classification KW - Photobacterium -- enzymology KW - Histamine -- biosynthesis KW - Seafood -- microbiology KW - Photobacterium -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1775382519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Photobacterium+angustum+and+Photobacterium+kishitanii%2C+Psychrotrophic+High-Level+Histamine-Producing+Bacteria+Indigenous+to+Tuna.&rft.au=Bjornsdottir-Butler%2C+K%3BMcCarthy%2C+S+A%3BDunlap%2C+P+V%3BBenner%2C+R+A&rft.aulast=Bjornsdottir-Butler&rft.aufirst=K&rft.date=2016-01-29&rft.volume=82&rft.issue=7&rft.spage=2167&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.02833-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Food Microbiol. 2011 Jun;28(4):828-37 [21511146] J Microbiol Methods. 2001 Jan;43(3):183-96 [11118653] Curr Microbiol. 2014 Mar;68(3):404-11 [24241330] J Food Prot. 2002 Mar;65(3):546-51 [11899055] Appl Environ Microbiol. 2003 May;69(5):2568-79 [12732523] Environ Microbiol. 2004 Feb;6(2):145-58 [14756879] Int J Food Microbiol. 2004 Apr 1;92(1):79-87 [15033270] Arch Microbiol. 2004 May;181(5):352-61 [15034641] Ann Inst Pasteur (Paris). 1967 Apr;112(4):521-5 [5624740] J Bacteriol. 1971 Jul;107(1):268-94 [4935323] Arch Microbiol. 1976 Oct 11;110(1):101-20 [1015934] Appl Environ Microbiol. 1981 Jan;41(1):321-2 [7013698] J Biol Chem. 1986 Aug 25;261(24):11003-9 [3733745] Int J Syst Bacteriol. 1995 Jan;45(1):139-44 [7531996] Mol Microbiol. 1995 Jan;15(1):87-95 [7752899] Int J Food Microbiol. 1996 Jan;28(3):411-8 [8652349] J Mol Biol. 1998 Jul 31;280(5):847-58 [9671554] Appl Environ Microbiol. 2005 Mar;71(3):1417-24 [15746344] Environ Microbiol. 2005 Oct;7(10):1641-54 [16156737] Appl Environ Microbiol. 2006 Jul;72(7):4862-70 [16820481] Int J Syst Evol Microbiol. 2006 Oct;56(Pt 10):2473-9 [17012582] Appl Environ Microbiol. 2007 Mar;73(5):1467-73 [17220267] Int J Syst Evol Microbiol. 2007 Sep;57(Pt 9):2073-8 [17766874] J Appl Microbiol. 2009 Aug;107(2):485-97 [19302297] J Food Prot. 2009 Sep;72(9):1987-91 [19777904] Toxicon. 2010 Aug 15;56(2):231-43 [20152850] FEMS Microbiol Rev. 2011 Mar;35(2):324-42 [20883503] Food Microbiol. 2011 May;28(3):356-63 [21356438] Mol Biol Evol. 2013 Dec;30(12):2725-9 [24132122] Foodborne Pathog Dis. 2013 Dec;10(12):1059-66 [24093307] Syst Appl Microbiol. 2014 Jul;37(5):329-35 [24951451] Curr Microbiol. 2014 Nov;69(5):660-8 [24962598] J Food Sci. 2015 Jun;80(6):M1253-8 [25920380] J Food Prot. 2015 Jul;78(7):1335-42 [26197285] Int J Food Microbiol. 2000 Jun 30;58(1-2):1-37 [10898459] BMC Bioinformatics. 2013;14:60 [23432962] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/AEM.02833-15 ER - TY - JOUR T1 - Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response. AN - 1760922778; 26794659 AB - Intravascular hemolysis can result in hemoglobinuria with acute kidney injury. In this study we systematically explored two in vivo animal models and a related cell culture system to identify hemoglobinuria-triggered damage pathways. In models of stored blood transfusion and hemoglobin (Hb) exposure in guinea pigs and beagle dogs we found that hemoglobinuria led to intrarenal conversion of ferrous Hb(Fe(2+)) to ferric Hb(Fe(3+)), accumulation of free heme and Hb-cross-linking products, enhanced 4-hydroxynonenal reactivity in renal tissue, and acute tubule injury. These changes were associated in guinea pigs with activation of a renal cortex gene expression signature indicative of oxidative stress and activation of the unfolded protein response (UPR). Tubule cells of hemolytic animals demonstrated enhanced protein expression of heme oxygenase and heat shock protein and enhanced expression of acute kidney injury-related neutrophil gelatinase-associated lipocalin. These adverse changes were completely prevented by haptoglobin treatment. The in vivo findings were extrapolated to a MS-based proteome analysis of SILAC-labeled renal epithelial cells that were exposed to free heme within a concentration range estimate of renal tubule heme exposure. These experiments confirmed that free heme is a likely trigger of tubule barrier deregulation and oxidative cell damage and reinforced the hypothesis that uncontrolled free heme could trigger the UPR as an important pathway of renal injury during hemoglobinuria. JF - Cell death & disease AU - Deuel, J W AU - Schaer, C A AU - Boretti, F S AU - Opitz, L AU - Garcia-Rubio, I AU - Baek, J H AU - Spahn, D R AU - Buehler, P W AU - Schaer, D J AD - Division of Internal Medicine, University of Zürich, Zürich, Switzerland. ; Clinic for Small Animal Internal Medicine, University of Zürich, Zürich, Switzerland. ; Functional Genomics Center Zürich, Swiss Federal Institute of Technology Zürich/University of Zürich, Zürich, Switzerland. ; Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland. ; Laboratory of Biochemistry and Vascular Biology, Center of Biologics Evaluation and Research (CBER), FDA, Silver Spring, MA, USA. ; Institute of Anesthesiology, University of Zürich, Zürich, Switzerland. Y1 - 2016/01/21/ PY - 2016 DA - 2016 Jan 21 SP - 1 VL - 7 KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - Oxidation-Reduction KW - Animals KW - Guinea Pigs KW - Oxidative Stress KW - Hemolysis KW - Dogs KW - Acute Kidney Injury -- genetics KW - Acute Kidney Injury -- etiology KW - Hemoglobinuria -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760922778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+death+%26+disease&rft.atitle=Hemoglobinuria-related+acute+kidney+injury+is+driven+by+intrarenal+oxidative+reactions+triggering+a+heme+toxicity+response.&rft.au=Deuel%2C+J+W%3BSchaer%2C+C+A%3BBoretti%2C+F+S%3BOpitz%2C+L%3BGarcia-Rubio%2C+I%3BBaek%2C+J+H%3BSpahn%2C+D+R%3BBuehler%2C+P+W%3BSchaer%2C+D+J&rft.aulast=Deuel&rft.aufirst=J&rft.date=2016-01-21&rft.volume=7&rft.issue=&rft.spage=e2064&rft.isbn=&rft.btitle=&rft.title=Cell+death+%26+disease&rft.issn=2041-4889&rft_id=info:doi/10.1038%2Fcddis.2015.392 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-09 N1 - Date created - 2016-01-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Blood. 2009 Mar 12;113(11):2578-86 [19131549] Nat Biotechnol. 2008 Dec;26(12):1367-72 [19029910] J Proteome Res. 2010 Aug 6;9(8):4061-70 [20568812] Am J Kidney Dis. 2010 Oct;56(4):780-4 [20605299] Methods Enzymol. 2011;490:71-92 [21266244] Nat Med. 2011 Feb;17(2):216-22 [21240264] Free Radic Biol Med. 2011 Jun 1;50(11):1480-7 [21334433] Nephrol Dial Transplant. 2011 Oct;26(10):3408-11 [21771756] Blood. 2012 Mar 8;119(10):2368-75 [22262768] J Clin Invest. 2012 Apr;122(4):1444-58 [22446185] J Am Chem Soc. 2012 Jun 27;134(25):10451-7 [22642538] Blood. 2013 Feb 21;121(8):1276-84 [23264591] Cold Spring Harb Perspect Med. 2013 Jun;3(6). pii: a013433. doi: 10.1101/cshperspect.a013433 [23645855] Cell Death Differ. 2013 Nov;20(11):1569-79 [23995229] Antioxid Redox Signal. 2013 Nov 10;19(14):1619-33 [23418677] Blood. 2014 Jan 16;123(3):377-90 [24277079] J Clin Invest. 2013 Nov;123(11):4809-20 [24084741] J Am Chem Soc. 2014 Mar 26;136(12):4551-6 [24592866] Pediatr Nephrol. 2014 Oct;29(10):1997-2003 [24890337] Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4110-8 [25225402] Semin Cell Dev Biol. 2014 Nov;35:24-32 [24582829] Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41 [25385600] Cell Death Differ. 2015 Apr;22(4):597-611 [25301065] Mol Cell. 2015 Jul 16;59(2):298-308 [26166707] Free Radic Biol Med. 2015 Dec;89:931-43 [26475040] Cell. 2001 Dec 28;107(7):881-91 [11779464] Blood. 2002 Aug 1;100(3):879-87 [12130498] Nat Med. 2002 Dec;8(12):1383-9 [12426562] Nat Rev Drug Discov. 2004 Feb;3(2):152-9 [15043006] Lab Invest. 1991 May;64(5):648-55 [2030579] Arterioscler Thromb. 1991 Nov-Dec;11(6):1700-11 [1931871] Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9285-9 [8415693] Annu Rev Biochem. 2005;74:739-89 [15952902] J Am Soc Nephrol. 2007 Feb;18(2):414-20 [17229906] J Biol Chem. 2007 Feb 16;282(7):4894-907 [17178725] J Biol Chem. 2007 Jul 13;282(28):20221-9 [17502383] N Engl J Med. 2008 Apr 24;358(17):1837 [18434653] Free Radic Biol Med. 2008 Oct 15;45(8):1150-8 [18708138] Nat Rev Drug Discov. 2008 Dec;7(12):1013-30 [19043451] Kidney Int. 2010 May;77(10):913-20 [20182411] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/cddis.2015.392 ER - TY - JOUR T1 - NAG-1/GDF15 accumulates in the nucleus and modulates transcriptional regulation of the Smad pathway. AN - 1760881599; 25893289 AB - Protein dynamics, modifications and trafficking are all processes that can modulate protein activity. Accumulating evidence strongly suggests that many proteins have distinctive roles dependent on cellular location. Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) is a transforming growth factor-β (TGF-β) superfamily protein that has a role in cancer, obesity and inflammation. NAG-1 is synthesized and cleaved into a mature peptide, which is ultimately secreted into the extracellular matrix (ECM). In this study, we have found that full-length NAG-1 is expressed in not only the cytoplasm and ECM, but also in the nucleus. NAG-1 is dynamically moved to the nucleus, exported into cytoplasm and further transported into the ECM. We have also found that nuclear NAG-1 contributes to inhibition of the Smad pathway by interrupting the Smad complex. Overall, our study indicates that NAG-1 is localized in the nucleus and provides new evidence that NAG-1 controls transcriptional regulation in the Smad pathway. JF - Oncogene AU - Min, K-W AU - Liggett, J L AU - Silva, G AU - Wu, W W AU - Wang, R AU - Shen, R-F AU - Eling, T E AU - Baek, S J AD - Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA. ; Facility for Biotechnology Resources, CBER, Food and Drug Administration, Bethesda, MD, USA. ; Laboratory of Molecular Carcinogenesis, NIH/NIEHS, Research Triangle Park, NC, USA. Y1 - 2016/01/21/ PY - 2016 DA - 2016 Jan 21 SP - 377 EP - 388 VL - 35 IS - 3 KW - GDF15 protein, human KW - 0 KW - Growth Differentiation Factor 15 KW - Smad Proteins KW - Index Medicus KW - Extracellular Matrix -- genetics KW - Promoter Regions, Genetic KW - Apoptosis -- genetics KW - Cytoplasm -- genetics KW - Humans KW - Cell Line, Tumor KW - Signal Transduction KW - Smad Proteins -- genetics KW - Smad Proteins -- metabolism KW - Growth Differentiation Factor 15 -- biosynthesis KW - Growth Differentiation Factor 15 -- genetics KW - Transcription, Genetic KW - Cell Nucleus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760881599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=NAG-1%2FGDF15+accumulates+in+the+nucleus+and+modulates+transcriptional+regulation+of+the+Smad+pathway.&rft.au=Min%2C+K-W%3BLiggett%2C+J+L%3BSilva%2C+G%3BWu%2C+W+W%3BWang%2C+R%3BShen%2C+R-F%3BEling%2C+T+E%3BBaek%2C+S+J&rft.aulast=Min&rft.aufirst=K-W&rft.date=2016-01-21&rft.volume=35&rft.issue=3&rft.spage=377&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2015.95 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-03 N1 - Date created - 2016-01-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Jun 30;275(26):20127-35 [10777512] Mol Cell Biol. 2000 Dec;20(23):9041-54 [11074002] Mol Pharmacol. 2001 Apr;59(4):901-8 [11259636] J Cell Sci. 2010 May 1;123(Pt 9):1438-48 [20356926] Nat Rev Cancer. 2010 Jun;10(6):415-24 [20495575] J Cell Biochem. 2010 Oct 15;111(3):755-67 [20665536] Mol Cell. 2010 Nov 24;40(4):521-32 [21095583] J Biol Chem. 2010 Dec 3;285(49):38720-9 [20937808] Biochem Pharmacol. 2011 Nov 1;82(9):1090-9 [21803025] Nat Cell Biol. 2011 Nov;13(11):1368-75 [21947082] FEBS J. 2011 Dec;278(24):4756-67 [22051117] J Biol Chem. 2012 Jan 6;287(2):819-31 [22110128] Nat Protoc. 2012 Mar;7(3):562-78 [22383036] Biochem Pharmacol. 2012 Apr 15;83(8):1021-32 [22209898] PLoS One. 2012;7(4):e34868 [22514681] J Cell Biochem. 2012 Jul;113(7):2193-200 [22388977] Toxicol Appl Pharmacol. 2012 Sep 1;263(2):225-32 [22750490] Nat Rev Mol Cell Biol. 2012 Oct;13(10):616-30 [22992590] Nat Rev Drug Discov. 2012 Oct;11(10):790-811 [23000686] Cardiovasc Pathol. 2012 Nov-Dec;21(6):499-505 [22386250] Biochem Pharmacol. 2013 Mar 1;85(5):597-606 [23220538] Mediators Inflamm. 2013;2013:641851 [23737651] Life Sci. 2014 Apr 1;100(2):75-84 [24530873] Nat Med. 2014 May;20(5):493-502 [24784232] Cancer Res. 2001 Sep 1;61(17):6307-12 [11522616] J Biol Chem. 2001 Sep 7;276(36):33384-92 [11445565] Carcinogenesis. 2002 Mar;23(3):425-34 [11895857] Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11514-9 [9326641] Biochim Biophys Acta. 1997 Oct 9;1354(1):40-4 [9375789] J Biol Chem. 1998 May 29;273(22):13760-7 [9593718] Genes Dev. 1998 Jul 15;12(14):2114-9 [9679056] Proc Natl Acad Sci U S A. 1997 May 13;94(10):5095-100 [9144196] Gene. 1999 Sep 3;237(1):105-11 [10524241] J Pharmacol Exp Ther. 2002 Jun;301(3):1126-31 [12023546] Oncogene. 2002 Jun 20;21(27):4212-9 [12082608] J Biol Chem. 2003 Feb 21;278(8):5845-53 [12475986] Cancer Res. 2003 May 1;63(9):2256-67 [12727848] Nat Rev Mol Cell Biol. 2003 Sep;4(9):690-9 [14506472] J Biol Chem. 2004 Feb 20;279(8):6883-92 [14662774] J Biol Chem. 2004 Nov 26;279(48):49617-23 [15377673] Carcinogenesis. 2004 Dec;25(12):2425-32 [15308587] Biochem Biophys Res Commun. 2005 Mar 4;328(1):63-9 [15670751] Cancer Res. 2005 Mar 15;65(6):2330-6 [15781647] J Biol Chem. 2005 May 13;280(19):18636-42 [15757899] Shock. 2005 Jun;23(6):543-8 [15897808] Mol Pharmacol. 2005 Dec;68(6):1782-92 [16155208] Genes Dev. 2005 Dec 1;19(23):2783-810 [16322555] Prog Lipid Res. 2006 Jan;45(1):1-16 [16337272] Circ Res. 2006 Feb 17;98(3):342-50 [16397142] Cancer Gene Ther. 2006 Feb;13(2):115-24 [16138117] Carcinogenesis. 2006 May;27(5):972-81 [16286461] Gastroenterology. 2006 Nov;131(5):1553-60 [17101328] Trends Cell Biol. 2007 Apr;17(4):193-201 [17317185] J Biol Chem. 2007 Sep 21;282(38):27685-92 [17652081] Mol Carcinog. 2008 Mar;47(3):197-208 [18058799] J Biol Chem. 2008 Apr 4;283(14):8984-94 [18238777] Mol Cancer Ther. 2008 Sep;7(9):2779-87 [18790758] Mol Cancer Ther. 2008 Dec;7(12):3739-50 [19074849] Cancer Prev Res (Phila). 2009 May;2(5):450-8 [19401523] Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10171-6 [19520826] BMC Bioinformatics. 2009;10:202 [19563654] Future Oncol. 2009 Sep;5(7):993-1003 [19792968] Cell. 2009 Nov 13;139(4):757-69 [19914168] J Cancer Res Clin Oncol. 2010 Apr;136(4):571-6 [19784846] BMC Cell Biol. 2010;11:20 [20230640] Int J Obes (Lond). 2014 Dec;38(12):1555-64 [24531647] Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):109-14 [10618379] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/onc.2015.95 ER - TY - JOUR T1 - A Simple Pharmacokinetic Model of Prenatal and Postnatal Exposure to Perfluoroalkyl Substances (PFASs). AN - 1760897645; 26691063 AB - Most children are exposed to perfluoroalkyl substances (PFASs) through placental transfer, breastfeeding, and other environmental sources. To date, there are no validated tools to estimate exposure and body burden during infancy and childhood. In this study, we aimed to (i) develop a two-generation pharmacokinetic model of prenatal and postnatal exposure to perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), and perfluorohexanesulfonate (PFHxS); and to (ii) evaluate it against measured children's levels in two studies. We developed a pharmacokinetic model consisting of a maternal and a child compartment to simulate lifetime exposure in women and transfer to the child across the placenta and through breastfeeding. To evaluate the model, we performed simulations for each mother-child dyad from two studies in which maternal PFAS levels at delivery and children's PFAS levels were available. Model predictions based on maternal PFAS levels, sex of child, body weight, and duration of breastfeeding explained between 52% and 60% of the variability in measured children's levels at 6 months of age and between 52% and 62% at 36 months. Monte Carlo simulations showed that the daily intake through breastfeeding and resulting internal PFAS levels can be much higher in nursing infants than in mothers. This pharmacokinetic model shows potential for postnatal exposure assessment in the context of epidemiological studies and risk assessment. JF - Environmental science & technology AU - Verner, Marc-André AU - Ngueta, Gérard AU - Jensen, Elizabeth T AU - Fromme, Hermann AU - Völkel, Wolfgang AU - Nygaard, Unni Cecilie AU - Granum, Berit AU - Longnecker, Matthew P AD - National Institute of Environmental Health Sciences, National Institutes of Health , Department of Health and Human Services, Research Triangle Park, North Carolina 27709, United States. ; Department of Chemical Safety and Toxicology, Bavarian Health and Food Safety Authority , D-80538 Munich, Germany. ; Division of Environmental Medicine, Norwegian Institute of Public Health , PO Box 4404 Nydalen, 0403 Oslo, Norway. Y1 - 2016/01/19/ PY - 2016 DA - 2016 Jan 19 SP - 978 EP - 986 VL - 50 IS - 2 KW - Alkanesulfonic Acids KW - 0 KW - Caprylates KW - Environmental Pollutants KW - Fluorocarbons KW - Sulfonic Acids KW - perfluorohexanesulfonic acid KW - 355-46-4 KW - perfluorooctanoic acid KW - 947VD76D3L KW - perfluorooctane sulfonic acid KW - 9H2MAI21CL KW - Index Medicus KW - Fluorocarbons -- pharmacokinetics KW - Caprylates -- adverse effects KW - Breast Feeding KW - Mothers KW - Alkanesulfonic Acids -- pharmacokinetics KW - Humans KW - Infant, Newborn KW - Placenta -- drug effects KW - Child KW - Monte Carlo Method KW - Pregnancy KW - Child, Preschool KW - Infant KW - Sulfonic Acids -- pharmacokinetics KW - Adult KW - Alkanesulfonic Acids -- adverse effects KW - Fluorocarbons -- adverse effects KW - Caprylates -- pharmacokinetics KW - Sulfonic Acids -- adverse effects KW - Male KW - Female KW - Prenatal Exposure Delayed Effects KW - Models, Theoretical KW - Environmental Exposure -- adverse effects KW - Environmental Pollutants -- blood KW - Environmental Pollutants -- pharmacokinetics KW - Environmental Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760897645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science+%26+technology&rft.atitle=A+Simple+Pharmacokinetic+Model+of+Prenatal+and+Postnatal+Exposure+to+Perfluoroalkyl+Substances+%28PFASs%29.&rft.au=Verner%2C+Marc-Andr%C3%A9%3BNgueta%2C+G%C3%A9rard%3BJensen%2C+Elizabeth+T%3BFromme%2C+Hermann%3BV%C3%B6lkel%2C+Wolfgang%3BNygaard%2C+Unni+Cecilie%3BGranum%2C+Berit%3BLongnecker%2C+Matthew+P&rft.aulast=Verner&rft.aufirst=Marc-Andr%C3%A9&rft.date=2016-01-19&rft.volume=50&rft.issue=2&rft.spage=978&rft.isbn=&rft.btitle=&rft.title=Environmental+science+%26+technology&rft.issn=1520-5851&rft_id=info:doi/10.1021%2Facs.est.5b04399 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-12 N1 - Date created - 2016-01-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.est.5b04399 ER - TY - JOUR T1 - Capillary electrophoresis coupled with inductively coupled mass spectrometry as an alternative to cloud point extraction based methods for rapid quantification of silver ions and surface coated silver nanoparticles. AN - 1760872319; 26724893 AB - Speciation and accurate quantification of ionic silver and metallic silver nanoparticles are critical to investigate silver toxicity and to determine the shelf-life of products that contain nano silver under various storage conditions. We developed a rapid method for quantification of silver ions and silver nanoparticles using capillary electrophoresis (CE) interfaced with inductively-coupled plasma mass spectrometry (ICPMS). The addition of 2-mercaptopropionylglycine (tiopronin) to the background electrolyte was used to facilitate the chromatographic separation of ionic silver and maintain the oxidation state of silver. The obtained limits of detection were 0.05 μg kg(-1) of silver nanoparticles and 0.03 μg kg(-1) of ionic silver. Nanoparticles of varied sizes (10-110 nm) with different surface coating, including citrate acid, lipoic acid, polyvinylpyrrolidone and bovine serum albumin (BSA) were successfully analyzed. Particularly good recoveries (>93%) were obtained for both ionic silver and silver nanoparticle in the presence of excess amount of BSA. The method was further tested with six commercially available dietary supplements which varied in concentration and matrix components. The summed values of silver ions and silver nanoparticles correlated well with the total silver concentration determined by ICPMS after acid digestion. This method can serve as an alternative to cloud point extraction technique when the extraction efficiency for protein coated nanoparticles is low. Copyright © 2015 Elsevier B.V. All rights reserved. JF - Journal of chromatography. A AU - Qu, Haiou AU - Mudalige, Thilak K AU - Linder, Sean W AD - U.S. Food and Drug Administration, Office of Regulatory Affairs, Arkansas Regional Laboratory 3900 NCTR Road, Jefferson, AR 72079, United States. ; U.S. Food and Drug Administration, Office of Regulatory Affairs, Arkansas Regional Laboratory 3900 NCTR Road, Jefferson, AR 72079, United States. Electronic address: Thilak.Mudalige@fda.hhs.gov. ; U.S. Food and Drug Administration, Office of Regulatory Affairs, Arkansas Regional Laboratory 3900 NCTR Road, Jefferson, AR 72079, United States. Electronic address: Sean.Linder@fda.hhs.gov. Y1 - 2016/01/15/ PY - 2016 DA - 2016 Jan 15 SP - 348 EP - 353 VL - 1429 KW - Ions KW - 0 KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - Capillary electrophoresis KW - Ionic silver KW - Speciation and quantification KW - Silver nanoparticles KW - Inductively coupled mass spectrometry KW - Ions -- analysis KW - Dietary Supplements -- analysis KW - Mass Spectrometry KW - Silver -- analysis KW - Chemistry Techniques, Analytical -- methods KW - Metal Nanoparticles -- analysis KW - Electrophoresis, Capillary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760872319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+A&rft.atitle=Capillary+electrophoresis+coupled+with+inductively+coupled+mass+spectrometry+as+an+alternative+to+cloud+point+extraction+based+methods+for+rapid+quantification+of+silver+ions+and+surface+coated+silver+nanoparticles.&rft.au=Qu%2C+Haiou%3BMudalige%2C+Thilak+K%3BLinder%2C+Sean+W&rft.aulast=Qu&rft.aufirst=Haiou&rft.date=2016-01-15&rft.volume=1429&rft.issue=&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+A&rft.issn=1873-3778&rft_id=info:doi/10.1016%2Fj.chroma.2015.12.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-03 N1 - Date created - 2016-01-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Anal Chem. 2011 Sep 1;83(17):6875-82 [21797201] Toxicol Lett. 2012 Feb 5;208(3):286-92 [22101214] Environ Sci Technol. 2012 May 15;46(10):5378-86 [22502776] Toxicol In Vitro. 2013 Feb;27(1):305-13 [22954533] Environ Sci Technol. 2013 Jan 15;47(2):757-64 [23237319] Environ Sci Technol. 2013 Jul 16;47(14):7713-21 [23731169] Environ Sci Technol. 2014;48(1):316-22 [24328348] Part Fibre Toxicol. 2014;11:11 [24529161] Langmuir. 2014 Sep 30;30(38):11442-52 [25137213] Anal Chem. 2014 Dec 2;86(23):11620-7 [25354835] Environ Sci Technol. 2014 Dec 16;48(24):14516-24 [25417798] Anal Chem. 2015 Feb 3;87(3):1764-72 [25556296] Int J Hyg Environ Health. 2015 May;218(3):345-57 [25747543] J Agric Food Chem. 2015 Apr 1;63(12):3153-60 [25751525] Anal Chem. 2015 Jul 21;87(14):7395-401 [26095720] J Chromatogr A. 2015 Nov 13;1420:92-7 [26456512] Arthritis Rheum. 1982 Aug;25(8):923-9 [7115451] Electrophoresis. 2005 Apr;26(7-8):1606-14 [15761918] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chroma.2015.12.033 ER - TY - JOUR T1 - FDA Approval of Flibanserin--Treating Hypoactive Sexual Desire Disorder. AN - 1760866840; 26649985 JF - The New England journal of medicine AU - Joffe, Hylton V AU - Chang, Christina AU - Sewell, Catherine AU - Easley, Olivia AU - Nguyen, Christine AU - Dunn, Somya AU - Lehrfeld, Kimberly AU - Lee, LaiMing AU - Kim, Myong-Jin AU - Slagle, Ashley F AU - Beitz, Julie AD - From the Food and Drug Administration, Silver Spring, MD. Y1 - 2016/01/14/ PY - 2016 DA - 2016 Jan 14 SP - 101 EP - 104 VL - 374 IS - 2 KW - Benzimidazoles KW - 0 KW - Serotonin Agents KW - flibanserin KW - 37JK4STR6Z KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Drug Interactions KW - Premenopause KW - Humans KW - Female KW - Advisory Committees KW - United States Food and Drug Administration KW - Benzimidazoles -- adverse effects KW - Drug Approval KW - Serotonin Agents -- therapeutic use KW - Benzimidazoles -- therapeutic use KW - Serotonin Agents -- adverse effects KW - Sexual Dysfunctions, Psychological -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760866840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=FDA+Approval+of+Flibanserin--Treating+Hypoactive+Sexual+Desire+Disorder.&rft.au=Joffe%2C+Hylton+V%3BChang%2C+Christina%3BSewell%2C+Catherine%3BEasley%2C+Olivia%3BNguyen%2C+Christine%3BDunn%2C+Somya%3BLehrfeld%2C+Kimberly%3BLee%2C+LaiMing%3BKim%2C+Myong-Jin%3BSlagle%2C+Ashley+F%3BBeitz%2C+Julie&rft.aulast=Joffe&rft.aufirst=Hylton&rft.date=2016-01-14&rft.volume=374&rft.issue=2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMp1513686 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-19 N1 - Date created - 2016-01-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMp1513686 ER - TY - JOUR T1 - Cytotoxicity of pyrrolizidine alkaloid in human hepatic parenchymal and sinusoidal endothelial cells: Firm evidence for the reactive metabolites mediated pyrrolizidine alkaloid-induced hepatotoxicity. AN - 1752584992; 26365561 AB - Pyrrolizidine alkaloids (PAs) widely distribute in plants and can cause hepatic sinusoidal obstruction syndrome (HSOS), which typically presents as a primary sinusoidal endothelial cell damage. It is well-recognized that after ingestion, PAs undergo hepatic cytochromes P450 (CYPs)-mediated metabolic activation to generate dehydropyrrolizidine alkaloids (DHPAs), which are hydrolyzed to dehydroretronecine (DHR). DHPAs and DHR are reactive metabolites having same core pyrrole moiety, and can bind proteins to form pyrrole-protein adducts, which are believed as the primary cause for PA-induced HSOS. However, to date, the direct evidences supporting the toxicity of DHPAs and DHR in the liver, in particular in the sinusoidal endothelial cells, are lacking. Using human hepatic sinusoidal endothelial cells (HSEC) and HepG2 (representing hepatic parenchymal cells), cells that lack CYPs activity, this study determined the direct cytotoxicity of dehydromonocrotaline, a representative DHPA, and DHR, but no cytotoxicity of the intact PA (monocrotaline) in both cell lines, confirming that reactive metabolites mediate PA intoxication. Comparing with HepG2, HSEC had significantly lower basal glutathione (GSH) level, and was significantly more susceptible to the reactive metabolites with severer GSH depletion and pyrrole-protein adducts formation. The toxic potency of two reactive metabolites was also compared. DHPA was more reactive than DHR, leading to severer toxicity. In conclusion, our results unambiguously provided the first direct evidence for the critical role of DHPA and DHR in the reactive metabolites-mediated PA-induced hepatotoxicity, which occurs predominantly in HSEC due to severe GSH depletion and the significant formation of pyrrole-protein adducts in HSEC. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Chemico-biological interactions AU - Yang, Mengbi AU - Ruan, Jianqing AU - Fu, Peter P AU - Lin, Ge AD - School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines Between The Chinese University of Hong Kong and Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region; Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines Between The Chinese University of Hong Kong and Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China. Electronic address: linge@cuhk.edu.hk. Y1 - 2016/01/05/ PY - 2016 DA - 2016 Jan 05 SP - 119 EP - 126 VL - 243 KW - Cytotoxins KW - 0 KW - Proteins KW - Pyrroles KW - Pyrrolizidine Alkaloids KW - Index Medicus KW - Pyrrole-protein adducts KW - Pyrrolizidine alkaloids KW - Metabolic activation KW - Hepatic sinusoidal endothelial cell damage KW - Reactive metabolites KW - Hepatotoxicity KW - Endothelial Cells -- drug effects KW - Proteins -- chemistry KW - Cytotoxins -- metabolism KW - Hep G2 Cells KW - Cytotoxins -- toxicity KW - Humans KW - Pyrroles -- chemistry KW - Pyrroles -- metabolism KW - Proteins -- metabolism KW - Endothelial Cells -- pathology KW - Endothelial Cells -- metabolism KW - Liver -- pathology KW - Liver -- cytology KW - Chemical and Drug Induced Liver Injury -- pathology KW - Liver -- drug effects KW - Liver -- metabolism KW - Pyrrolizidine Alkaloids -- toxicity KW - Pyrrolizidine Alkaloids -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1752584992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Cytotoxicity+of+pyrrolizidine+alkaloid+in+human+hepatic+parenchymal+and+sinusoidal+endothelial+cells%3A+Firm+evidence+for+the+reactive+metabolites+mediated+pyrrolizidine+alkaloid-induced+hepatotoxicity.&rft.au=Yang%2C+Mengbi%3BRuan%2C+Jianqing%3BFu%2C+Peter+P%3BLin%2C+Ge&rft.aulast=Yang&rft.aufirst=Mengbi&rft.date=2016-01-05&rft.volume=243&rft.issue=&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2015.09.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-02 N1 - Date created - 2015-12-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cbi.2015.09.011 ER - TY - JOUR T1 - Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: estimates and risk factors AN - 1808610210; PQ0003232713 AB - Background: To estimate incidence and clearance of high-risk human papillomavirus (HR-HPV), and their risk factors, in men who have sex with men (MSM) recently infected by HIV in Spain; 2007-2013. Methods: Multicenter cohort. HR-HPV infection was determined and genotyped with linear array. Two-state Markov models and Poisson regression were used. Results: We analysed 1570 HR-HPV measurements of 612 MSM over 13 608 person-months (p-m) of follow-up. Median (mean) number of measurements was 2 (2.6), median time interval between measurements was 1.1 years (interquartile range: 0.89-1.4). Incidence ranged from 9.0 [95% confidence interval (CI) 6.8-11.8] per 1000 p-m for HPV59 to 15.9 (11.7-21.8) per 1000 p-m for HPV51. HPV16 and HPV18 had slightly above average incidence: 11.9/1000 p-m and 12.8/1000 p-m. HPV16 showed the lowest clearance for both 'prevalent positive' (15.7/1000 p-m; 95% CI 12.0-20.5) and 'incident positive' infections (22.1/1000 p-m; 95% CI 11.8-41.1). More sexual partners increased HR-HPV incidence, although it was not statistically significant. Age had a strong effect on clearance (P-value < 0.001) due to the elevated rate in MSM under age 25; the effect of HIV-RNA viral load was more gradual, with clearance rate decreasing at higher HIV-RNA viral load (P-value 0.008). Conclusion: No large variation in incidence by HR-HPV type was seen. The most common incident types were HPV51, HPV52, HPV31, HPV18 and HPV16. No major variation in clearance by type was observed, with the exception of HPV16 which had the highest persistence and potentially, the strongest oncogenic capacity. Those aged below 25 or with low HIV-RNA- viral load had the highest clearance. JF - AIDS AU - Geskus, Ronald B AU - Gonzalez, Cristina AU - Torres, Montserrat AU - Del Romero, Jorge AU - Viciana, Pompeyo AU - Masia, Mar AU - Blanco, Jose R AU - Iribarren, Mauricio AU - De Sanjose, Silvia AU - Hernandez-Novoa, Beatriz AU - Ortiz, Marta AU - Del Amo, Julia AD - Public Health Service of Amsterdam, jdamo@isciii.es Y1 - 2016/01/02/ PY - 2016 DA - 2016 Jan 02 SP - 37 EP - 44 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 30 IS - 1 SN - 0269-9370, 0269-9370 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - clearance KW - HIV KW - human papillomavirus KW - incidence KW - men who have sex with men KW - ANE, Spain KW - Acquired immune deficiency syndrome KW - Age KW - Males KW - Statistical analysis KW - Human papillomavirus 18 KW - Homosexuality KW - Infection KW - Sexual behavior KW - Models KW - Sexual partners KW - Human immunodeficiency virus KW - Human papillomavirus 16 KW - Risk factors KW - Regression analysis KW - Risk groups KW - Human papillomavirus KW - Sex KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808610210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Incidence+and+clearance+of+anal+high-risk+human+papillomavirus+in+HIV-positive+men+who+have+sex+with+men%3A+estimates+and+risk+factors&rft.au=Geskus%2C+Ronald+B%3BGonzalez%2C+Cristina%3BTorres%2C+Montserrat%3BDel+Romero%2C+Jorge%3BViciana%2C+Pompeyo%3BMasia%2C+Mar%3BBlanco%2C+Jose+R%3BIribarren%2C+Mauricio%3BDe+Sanjose%2C+Silvia%3BHernandez-Novoa%2C+Beatriz%3BOrtiz%2C+Marta%3BDel+Amo%2C+Julia&rft.aulast=Geskus&rft.aufirst=Ronald&rft.date=2016-01-02&rft.volume=30&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0000000000000874 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Sexual partners; Age; Risk factors; Regression analysis; Statistical analysis; Risk groups; Infection; Models; Sex; Acquired immune deficiency syndrome; Human immunodeficiency virus; Males; Homosexuality; Sexual behavior; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus; ANE, Spain DO - http://dx.doi.org/10.1097/QAD.0000000000000874 ER - TY - JOUR T1 - Profiling stainless steel welding processes to reduce fume emissions, hexavalent chromium emissions and operating costs in the workplace AN - 1790964769; PQ0003047867 AB - Nine gas metal arc welding (GMAW) processes for stainless steel were assessed for fume generation rates, fume generation rates per g of electrode consumed, and emission rates for hexavalent chromium (Cr super(6+)). Elemental manganese, nickel, chromium, iron emissions per unit length of weld, and labor plus consumables costs were similarly measured. Flux-cored arc welding and shielded metal arc (SMAW) processes were also studied. The objective was to identify the best welding processes for reducing workplace exposures, and estimate costs for all processes. Using a conical chamber, fumes were collected, weighed, recovered, and analyzed by inductively coupled atomic emission spectroscopy for metals, and by ion chromatography for Cr super(6+). GMAW processes used were Surface Tension Transfer, Regulated Metal Deposition, Cold Metal Transfer, short-circuit, axial spray, and pulsed spray modes. Flux-cored welding used gas shielding; SMAW used E308 rods. Costs were estimated as dollars per m length of a 14 in (6.3 mm) thick horizontal butt weld; equipment costs were estimated as ratios of new equipment costs to a 250 ampere capacity SMAW welding machine. Results indicate a broad range of fume emission factors for the processes studied. Fume emission rates per g of electrode were lowest for GMAW processes such as pulsed-spray mode (0.2 mg/g), and highest for SMAW (8 mg fume/g electrode). Emission rates of Cr super(6+) ranged from 50-7800 mu g/min, and Cr super(6+) generation rates per g electrode ranged from 1-270 mu g/g. Elemental Cr generation rates spanned 13-330 mu g/g. Manganese emission rates ranged from 50-300 mu g/g. Nickel emission rates ranged from 4-140 mu g/g. Labor and consumables costs ranged from $3.15 (GMAW pulsed spray) to $7.40 (SMAW) per meter of finished weld, and were measured or estimated for all 11 processes tested. Equipment costs for some processes may be as much as five times the cost of a typical SMAW welding machine. The results show that all of the GMAW processes in this study can substantially reduce fume, Cr super(6+), manganese and costs relative to SMAW, the most commonly used welding process, and several have exceptional capabilities for reducing emissions. JF - Journal of Occupational and Environmental Hygiene AU - Keane, Michael AU - Siert, Arlen AU - Stone, Samuel AU - Chen, Bean T AD - National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV Y1 - 2016/01/02/ PY - 2016 DA - 2016 Jan 02 SP - 1 EP - 8 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 1 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts KW - Heavy metals KW - Nickel KW - Spectroscopy KW - Emissions KW - Welding KW - Steel KW - Manganese KW - Occupational exposure KW - Environmental hygiene KW - Metals KW - Fumes KW - Chromium KW - Chromatography KW - Operating costs KW - Sprays KW - Pollutant deposition KW - Electrodes KW - Iron KW - Rods KW - stainless steel KW - P 0000:AIR POLLUTION KW - X 24360:Metals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790964769?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Profiling+stainless+steel+welding+processes+to+reduce+fume+emissions%2C+hexavalent+chromium+emissions+and+operating+costs+in+the+workplace&rft.au=Keane%2C+Michael%3BSiert%2C+Arlen%3BStone%2C+Samuel%3BChen%2C+Bean+T&rft.aulast=Keane&rft.aufirst=Michael&rft.date=2016-01-02&rft.volume=13&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2015.1072634 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Fumes; Chromium; Heavy metals; Chromatography; Nickel; Spectroscopy; Electrodes; Welding; Manganese; Iron; Rods; stainless steel; Environmental hygiene; Metals; Sprays; Operating costs; Pollutant deposition; Emissions; Steel; Occupational exposure DO - http://dx.doi.org/10.1080/15459624.2015.1072634 ER - TY - JOUR T1 - Interlaboratory evaluation of cellulosic acid-soluble internal air sampling capsules for multi-element analysis AN - 1790959297; PQ0003047868 AB - An interlaboratory study was carried out to evaluate the use of acid-soluble cellulosic air sampling capsules for their suitability in the measurement of trace elements in workplace atmospheric samples. These capsules are used as inserts to perform closed-face cassette sample collection for occupational exposure monitoring. The interlaboratory study was performed in accordance with NIOSH guidelines that describe statistical procedures for evaluating measurement accuracy of air monitoring methods. The performance evaluation materials used consisted of cellulose acetate capsules melded to mixed-cellulose ester filters that were dosed with multiple elements from commercial standard aqueous solutions. The cellulosic capsules were spiked with the following 33 elements of interest in workplace air monitoring: Ag, Al, As, Ba, Be, Ca, Cd, Co, Cr, Cu, Fe, In, K, La, Li, Mg, Mn, Mo, Ni, P, Pb, Sb, Se, Sn, Sr, Te, Ti, Tl, V, W, Y, Zn, Zr. The elemental loading levels were certified by an accredited provider of certified reference materials. Triplicates of media blanks and multielement-spiked capsules at three different elemental loadings were sent to each participating laboratory; the elemental loading levels were not revealed to the laboratories. The volunteer participating laboratories were asked to prepare the samples by acid dissolution and to analyze aliquots of extracted samples by inductively coupled plasma atomic emission spectrometry in accordance with NIOSH methods. It was requested that the study participants report their analytical results in units of mu g of each target element per internal capsule sample. For the majority of the elements investigated (30 out of 33), the study accuracy estimates obtained satisfied the NIOSH accuracy criterion (A < 25%). This investigation demonstrates the utility of acid-soluble internal sampling capsules for multielement analysis by atomic spectrometry. JF - Journal of Occupational and Environmental Hygiene AU - Andrews, Ronnee N AU - Feng, HAmy AU - Ashley, Kevin AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2016/01/02/ PY - 2016 DA - 2016 Jan 02 SP - 40 EP - 47 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 13 IS - 1 SN - 1545-9624, 1545-9624 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Pollution monitoring KW - Cellulose KW - Guidelines KW - Esters KW - Lead KW - Trace elements KW - Spectrometry KW - Filters KW - Zinc KW - Emissions KW - Air sampling KW - Cadmium KW - Occupational exposure KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790959297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Interlaboratory+evaluation+of+cellulosic+acid-soluble+internal+air+sampling+capsules+for+multi-element+analysis&rft.au=Andrews%2C+Ronnee+N%3BFeng%2C+HAmy%3BAshley%2C+Kevin&rft.aulast=Andrews&rft.aufirst=Ronnee&rft.date=2016-01-02&rft.volume=13&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2015.1072635 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Pollution monitoring; Guidelines; Cellulose; Esters; Lead; Spectrometry; Trace elements; Filters; Zinc; Air sampling; Emissions; Cadmium; Occupational exposure DO - http://dx.doi.org/10.1080/15459624.2015.1072635 ER - TY - JOUR T1 - Cooking rice in excess water reduces both arsenic and enriched vitamins in the cooked grain AN - 1773828392; PQ0002712538 AB - This paper reports the effects of rinsing rice and cooking it in variable amounts of water on total arsenic, inorganic arsenic, iron, cadmium, manganese, folate, thiamin and niacin in the cooked grain. We prepared multiple rice varietals both rinsed and unrinsed and with varying amounts of cooking water. Rinsing rice before cooking has a minimal effect on the arsenic (As) content of the cooked grain, but washes enriched iron, folate, thiamin and niacin from polished and parboiled rice. Cooking rice in excess water efficiently reduces the amount of As in the cooked grain. Excess water cooking reduces average inorganic As by 40% from long grain polished, 60% from parboiled and 50% from brown rice. Iron, folate, niacin and thiamin are reduced by 50-70% for enriched polished and parboiled rice, but significantly less so for brown rice, which is not enriched. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Gray, Patrick J AU - Conklin, Sean D AU - Todorov, Todor I AU - Kasko, Sasha M AD - Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration (USFDA), College Park, MD, USA Y1 - 2016/01/02/ PY - 2016 DA - 2016 Jan 02 SP - 78 EP - 85 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 33 IS - 1 SN - 1944-0049, 1944-0049 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Arsenic KW - Food additives KW - Vitamins KW - Cooking KW - Cadmium KW - Grains KW - Iron KW - Manganese KW - R2 23060:Medical and environmental health KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773828392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Cooking+rice+in+excess+water+reduces+both+arsenic+and+enriched+vitamins+in+the+cooked+grain&rft.au=Gray%2C+Patrick+J%3BConklin%2C+Sean+D%3BTodorov%2C+Todor+I%3BKasko%2C+Sasha+M&rft.aulast=Gray&rft.aufirst=Patrick&rft.date=2016-01-02&rft.volume=33&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1103906 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Arsenic; Vitamins; Cooking; Cadmium; Grains; Manganese; Iron DO - http://dx.doi.org/10.1080/19440049.2015.1103906 ER - TY - JOUR T1 - Effect of Trehalose and Trehalose Transport on the Tolerance of Clostridium perfringens to Environmental Stress in a Wild Type Strain and Its Fluoroquinolone-Resistant Mutant AN - 1868335351; PQ0004047562 AB - Trehalose has been shown to protect bacterial cells from environmental stress. Its uptake and osmoprotective effect in Clostridium perfringens were investigated by comparing wild type C. perfringens ATCC 13124 with a fluoroquinolone- (gatifloxacin-) resistant mutant. In a chemically defined medium, trehalose and sucrose supported the growth of the wild type but not that of the mutant. Microarray data and qRT-PCR showed that putative genes for the phosphorylation and transport of sucrose and trehalose (via phosphoenolpyruvate-dependent phosphotransferase systems, PTS) and some regulatory genes were downregulated in the mutant. The wild type had greater tolerance than the mutant to salts and low pH; trehalose and sucrose further enhanced the osmotolerance of the wild type to NaCl. Expression of the trehalose-specific PTS was lower in the fluoroquinolone-resistant mutant. Protection of C. perfringens from environmental stress could therefore be correlated with the ability to take up trehalose. JF - International Journal of Microbiology AU - Park, Miseon AU - Mitchell, Wilfrid J AU - Rafii, Fatemeh AD - Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA, fatemeh.rafii@fda.hhs.gov Y1 - 2016/01// PY - 2016 DA - January 2016 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2016 SN - 1687-918X, 1687-918X KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salts KW - Phosphorylation KW - Sucrose KW - Clostridium perfringens KW - Environmental stress KW - Resistant mutant KW - Trehalose KW - phosphotransferase KW - pH effects KW - Sodium chloride KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868335351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Microbiology&rft.atitle=Effect+of+Trehalose+and+Trehalose+Transport+on+the+Tolerance+of+Clostridium+perfringens+to+Environmental+Stress+in+a+Wild+Type+Strain+and+Its+Fluoroquinolone-Resistant+Mutant&rft.au=Park%2C+Miseon%3BMitchell%2C+Wilfrid+J%3BRafii%2C+Fatemeh&rft.aulast=Park&rft.aufirst=Miseon&rft.date=2016-01-01&rft.volume=2016&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Microbiology&rft.issn=1687918X&rft_id=info:doi/10.1155%2F2016%2F4829716 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Salts; Phosphorylation; Sucrose; Resistant mutant; Environmental stress; phosphotransferase; Trehalose; pH effects; Sodium chloride; Clostridium perfringens DO - http://dx.doi.org/10.1155/2016/4829716 ER - TY - JOUR T1 - Mapping of ultimate properties of coal using isometric log-ratio transformation and sequential Gaussian simulation AN - 1861086287; 784667-92 AB - Chemical and compositional properties of coal largely determine the coal handling, processing, beneficiation methods and design of coal-fired power plants. Furthermore, these properties impact coal strength, coal blending during mining as well as coal's gas content, which is important for mining safety. In order for these processes and quantitative predictions to be successful, safer and economically feasible, it is important to determine and map chemical and compositional properties of coals accurately in order to infer these properties prior to mining. Ultimate analysis quantifies the principal chemical elements in coal. These elements are C, H, N, S, O and depending on the basis, ash and/or moisture. The basis for the data is determined by the condition of the sample at the time of analysis, with "as-received" basis being the closest to sampling conditions and thus to the in-situ conditions of the coal. The parts determined or calculated as the result of ultimate analyses are compositions, reported in weight percent, and pose the challenges of statistical analyses of compositional data. The treatment of parts using proper compositional methods may be even more important in mapping them, as most mapping methods carry uncertainty due to partial sampling as well. In this work, we map the ultimate analyses parts of the Springfield coal, from an Indiana section of the Illinois basin, USA, using sequential Gaussian simulation of isometric log-ratio transformed compositions. We compare the results with those of direct simulations of compositional parts. We also compare the implications of these approaches in calculating other properties using correlations to identify the differences and consequences. JF - International Geological Congress, Abstracts = Congres Geologique International, Resumes AU - Karacan, C Oezgen AU - Olea, Ricardo A AU - Anonymous Y1 - 2016 PY - 2016 DA - 2016 EP - Abstract 2112 PB - [International Geological Congress], [location varies] VL - 35 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1861086287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefinprocess&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Geological+Congress%2C+Abstracts+%3D+Congres+Geologique+International%2C+Resumes&rft.atitle=Mapping+of+ultimate+properties+of+coal+using+isometric+log-ratio+transformation+and+sequential+Gaussian+simulation&rft.au=Karacan%2C+C+Oezgen%3BOlea%2C+Ricardo+A%3BAnonymous&rft.aulast=Karacan&rft.aufirst=C&rft.date=2016-01-01&rft.volume=35&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Geological+Congress%2C+Abstracts+%3D+Congres+Geologique+International%2C+Resumes&rft.issn=&rft_id=info:doi/ L2 - http://www.americangeosciences.org/sites/default/files/igc/2112.pdf LA - English DB - GeoRef N1 - Conference title - 35th international geological congress N1 - Copyright - GeoRef in Process, Copyright 2017, American Geosciences Institute. After editing and indexing, this record will be added to Georef. Reference includes data supplied by International Geological Congress Organizational Committee N1 - Last updated - 2017-01-24 N1 - CODEN - IGABBY ER - TY - JOUR T1 - Audit of Helicobacter pylori Testing in Microbiology Laboratories in England: To Inform Compliance with NICE Guidance and the Feasibility of Routine Antimicrobial Resistance Surveillance AN - 1846418636; PQ0003878858 AB - Introduction . The National Institute for Health and Clinical Excellence (NICE) guidance recommends that dyspeptic patients are tested for Helicobacter pylori using a urea breath test, stool antigen test, or serology. Antibiotic resistance in H. pylori is globally increasing, but treatment in England is rarely guided by susceptibility testing or surveillance. Aims . To determine compliance of microbiology laboratories in England with NICE guidance and whether laboratories perform culture and antibiotic susceptibility testing (AST). Methods . In 2015, 170 accredited English microbiology laboratories were surveyed, by email. Results . 121/170 (71%) laboratories responded; 96% provided H. pylori testing (78% on site). 94% provided H. pylori diagnosis using stool antigen; only four provided serology as their noninvasive test; 3/4 of these encouraged urea breath tests in their acute trusts. Only 22/94 (23%) of the laboratories performed H. pylori cultures from gastric biopsies on site; 9/22 performed AST, but the vast majority processed less than one specimen/week. Conclusions . Only five laboratories in England do not comply with NICE guidance; these will need the guidance reinforced. National surveillance needs to be implemented; culture-based AST would need to be centralised. Moving forward, detection of resistance in H. pylori from stool specimens using molecular methods (PCR) needs to be explored. JF - International Journal of Microbiology AU - Allison, Rosalie AU - Lecky, Donna M AU - Bull, Megan AU - Turner, Kim AU - Godbole, Gauri AU - McNulty, Cliodna AM AD - Primary Care Unit, Public Health England, Microbiology Department, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK, cliodna.mcnulty@phe.gov.uk Y1 - 2016/01// PY - 2016 DA - January 2016 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2016 SN - 1687-918X, 1687-918X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Drug resistance KW - Laboratories KW - Polymerase chain reaction KW - Urea KW - Biopsy KW - Antibiotics KW - Feces KW - Serology KW - Antibiotic resistance KW - A 01300:Methods KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846418636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Microbiology&rft.atitle=Audit+of+Helicobacter+pylori+Testing+in+Microbiology+Laboratories+in+England%3A+To+Inform+Compliance+with+NICE+Guidance+and+the+Feasibility+of+Routine+Antimicrobial+Resistance+Surveillance&rft.au=Allison%2C+Rosalie%3BLecky%2C+Donna+M%3BBull%2C+Megan%3BTurner%2C+Kim%3BGodbole%2C+Gauri%3BMcNulty%2C+Cliodna+AM&rft.aulast=Allison&rft.aufirst=Rosalie&rft.date=2016-01-01&rft.volume=2016&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Microbiology&rft.issn=1687918X&rft_id=info:doi/10.1155%2F2016%2F8540904 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-12-01 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Laboratories; Drug resistance; Polymerase chain reaction; Antibiotics; Biopsy; Urea; Feces; Serology; Antibiotic resistance; Helicobacter pylori DO - http://dx.doi.org/10.1155/2016/8540904 ER - TY - JOUR T1 - Program and Policy Evaluations in Practice: Highlights from the Federal Perspective AN - 1846079723 AB - This paper examines the intersection of evaluation methods and usefulness of research for policy and practice from the vantage point of federal agencies that commission a large share of domestic program evaluations with the goal of improving the ability of the government to invest its scarce dollars wisely. Toward this end, the paper revisits the prominent issues discussed in prior chapters through a lens focused on understanding conditions under which particular methodological strategies are and are not helpful in advancing the job of policy analysts, policymakers, and program administrators. The aim is to provide useful guidance to evaluators in how to interact productively with the evaluation funders and intended end-users regarding how they might make their products most useful. JF - New Directions for Evaluation AU - Maynard, Rebecca AU - Goldstein, Naomi AU - Nightingale, Demetra Smith AD - University of Pennsylvania ; Administration for Children and Families, U.S. Department of Health and Human Services ; U.S. Department of Labor ; University of Pennsylvania Y1 - 2016///Winter PY - 2016 DA - Winter 2016 SP - 109 EP - 135 CY - Fairhaven PB - Wiley Subscription Services, Inc. VL - 2016 IS - 152 SN - 1097-6736 KW - Education KW - Government Agencies KW - Administrators KW - Evaluation Research KW - Program Evaluation KW - 0624:complex organization; bureaucratic structure/organizational sociology KW - 9261:public policy/administration; public policy KW - 9105:politics; national-level politics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1846079723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+Directions+for+Evaluation&rft.atitle=Program+and+Policy+Evaluations+in+Practice%3A+Highlights+from+the+Federal+Perspective&rft.au=Maynard%2C+Rebecca%3BGoldstein%2C+Naomi%3BNightingale%2C+Demetra+Smith&rft.aulast=Maynard&rft.aufirst=Rebecca&rft.date=2016-01-01&rft.volume=2016&rft.issue=152&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=New+Directions+for+Evaluation&rft.issn=10976736&rft_id=info:doi/10.1002%2Fev.20209 LA - English DB - Sociological Abstracts; Worldwide Political Science Abstracts N1 - Copyright - Copyright © 2016 Wiley Periodicals, Inc., A Wiley Company, and the American Evaluation Association N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1002/ev.20209 ER - TY - JOUR T1 - Polycyclic aromatic hydrocarbons: determinants of residential carpet dust levels and risk of non-Hodgkin lymphoma AN - 1842513800; PQ0002586008 AB - To investigate the risk of non-Hodgkin lymphoma (NHL) associated with residential carpet dust measurements of polycyclic aromatic hydrocarbons (PAHs). We evaluated the relationship between residential carpet dust PAH concentrations (benz(a)anthracene, benzo(a)pyrene, benzo(b)fluoranthene, benzo(k)fluoranthene, chrysene, dibenz(a,h)anthracene, and indeno(1,2,3-c,d)pyrene, and their sum) and risk of NHL (676 cases, 511 controls) in the National Cancer Institute Surveillance Epidemiology and End Results multicenter case-control study. As a secondary aim, we investigated determinants of dust PAH concentrations. We computed odds ratios (OR) and 95 % confidence interval (CI) for associations between NHL and concentrations of individual and summed PAHs using unconditional logistic regression, adjusting for age, gender, and study center. Determinants of natural log-transformed PAHs were investigated using multivariate least-squares regression. We observed some elevated risks for NHL overall and B cell lymphoma subtypes in association with quartiles or tertiles of PAH concentrations, but without a monotonic trend, and there was no association comparing the highest quartile or tertile to the lowest. In contrast, risk of T cell lymphoma was significantly increased among participants with the highest tertile of summed PAHs (OR = 3.04; 95 % CI, 1.09-8.47) and benzo(k)fluoranthene (OR = 3.20; 95 % CI, 1.13-9.11) compared with the lowest tertile. Predictors of PAH dust concentrations in homes included ambient air PAH concentrations and the proportion of developed land within 2 km of a residence. Older age, more years of education, and white race were also predictive of higher levels in homes. Our results suggest a potential link between PAH exposure and risk of T cell lymphoma and demonstrate the importance of analyzing risk by NHL histologic type. JF - Cancer Causes & Control AU - DellaValle, Curt T AU - Deziel, Nicole C AU - Jones, Rena R AU - Colt, Joanne S AU - De Roos, Anneclaire J AU - Cerhan, James R AU - Cozen, Wendy AU - Severson, Richard K AU - Flory, Abigail R AU - Morton, Lindsay M AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), 9609 Medical Center Dr, Room 6E138 MSC 9771, Bethesda, MD, 20892, USA, wardm@mail.nih.gov Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 1 EP - 13 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 27 IS - 1 SN - 0957-5243, 0957-5243 KW - Toxicology Abstracts KW - Polycyclic aromatic hydrocarbons KW - B-cell lymphoma KW - Age KW - Dust KW - Chrysene KW - Epidemiology KW - Carpets KW - Risk factors KW - Geriatrics KW - Benzo(a)pyrene KW - T-cell lymphoma KW - Races KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842513800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Polycyclic+aromatic+hydrocarbons%3A+determinants+of+residential+carpet+dust+levels+and+risk+of+non-Hodgkin+lymphoma&rft.au=DellaValle%2C+Curt+T%3BDeziel%2C+Nicole+C%3BJones%2C+Rena+R%3BColt%2C+Joanne+S%3BDe+Roos%2C+Anneclaire+J%3BCerhan%2C+James+R%3BCozen%2C+Wendy%3BSeverson%2C+Richard+K%3BFlory%2C+Abigail+R%3BMorton%2C+Lindsay+M%3BWard%2C+Mary+H&rft.aulast=DellaValle&rft.aufirst=Curt&rft.date=2016-01-01&rft.volume=27&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-015-0660-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 48 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Chrysene; Age; B-cell lymphoma; Polycyclic aromatic hydrocarbons; Epidemiology; Carpets; Risk factors; Geriatrics; Benzo(a)pyrene; T-cell lymphoma; Races; Dust DO - http://dx.doi.org/10.1007/s10552-015-0660-y ER - TY - JOUR T1 - Obstacles and Enablers on the Way towards Integrated Physical Activity Policies for Childhood Obesity Prevention: An Exploration of Local Policy Officials' Views AN - 1837345625; PQ0003736784 AB - Background . Limited physical activity (PA) is a risk factor for childhood obesity. In Netherlands, as in many other countries worldwide, local policy officials bear responsibility for integrated PA policies, involving both health and nonhealth domains. In practice, its development seems hampered. We explore which obstacles local policy officials perceive in their effort. Methods . Fifteen semistructured interviews were held with policy officials from health and nonhealth policy domains, working at strategic, tactic, and operational level, in three relatively large municipalities. Questions focused on exploring perceived barriers for integrated PA policies. The interviews were deductively coded by applying the Behavior Change Ball framework. Findings . Childhood obesity prevention appeared on the governmental agenda and all officials understood the multicausal nature. However, operational officials had not yet developed a tradition to develop integrated PA policies due to insufficient boundary-spanning skills and structural and cultural differences between the domains. Tactical level officials did not sufficiently support intersectoral collaboration and strategic level officials mainly focused on public-private partnerships. Conclusion . Developing integrated PA policies is a bottom-up innovation process that needs to be supported by governmental leaders through better guiding organizational processes leading to such policies. Operational level officials can assist in this by making progress in intersectoral collaboration visible. JF - BioMed Research International AU - Hendriks, Anna-Marie AU - Habraken, Jolanda M AU - Kremers, Stef PJ AU - Jansen, Maria WJ AU - Oers, Hans van AU - Schuit, Albertine J AD - Academic Collaborative Centre for Public Health Limburg, Regional Public Health Service, Geleen, Netherlands, anna-marie.hendriks@maastrichtuniversity.nl Y1 - 2016/01// PY - 2016 DA - January 2016 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2016 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - Obesity KW - Physical activity KW - Risk factors KW - Development KW - Children KW - Physical training KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837345625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Obstacles+and+Enablers+on+the+Way+towards+Integrated+Physical+Activity+Policies+for+Childhood+Obesity+Prevention%3A+An+Exploration+of+Local+Policy+Officials%27+Views&rft.au=Hendriks%2C+Anna-Marie%3BHabraken%2C+Jolanda+M%3BKremers%2C+Stef+PJ%3BJansen%2C+Maria+WJ%3BOers%2C+Hans+van%3BSchuit%2C+Albertine+J&rft.aulast=Hendriks&rft.aufirst=Anna-Marie&rft.date=2016-01-01&rft.volume=2016&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2016%2F5739025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 3 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Obesity; Risk factors; Physical activity; Development; Children; Physical training DO - http://dx.doi.org/10.1155/2016/5739025 ER - TY - JOUR T1 - Corexit-EC9527A Disrupts Retinol Signaling and Neuronal Differentiation in P19 Embryonal Pluripotent Cells. AN - 1835523383; 27684493 AB - Corexit-EC9500A and Corexit-EC9527A are two chemical dispersants that have been used to remediate the impact of the 2010 Deepwater Horizon oil spill. Both dispersants are composed primarily of organic solvents and surfactants and act by emulsifying the crude oil to facilitate biodegradation. The potential adverse effect of the Corexit chemicals on mammalian embryonic development remains largely unknown. Retinol (vitamin A) signaling, mediated by all-trans retinoic acid (RA), is essential for neural tube formation and the development of many organs in the embryo. The physiological levels of RA in cells and tissues are maintained by the retinol signaling pathway (RSP), which controls the biosynthesis of RA from dietary retinol and the catabolism of RA to polar metabolites for removal. RA is a potent activating ligand for the RAR/RXR nuclear receptors. Through RA and the receptors, the RSP modulates the expression of many developmental genes; interference with the RSP is potentially teratogenic. In this study the mouse P19 embryonal pluripotent cell, which contains a functional RSP, was used to evaluate the effects of the Corexit dispersants on retinol signaling and associated neuronal differentiation. The results showed that Corexit-EC9500A was more cytotoxic than Corexit-EC9527A to P19 cells. At non-cytotoxic doses, Corexit-EC9527A inhibited retinol-induced expression of the Hoxa1 gene, which encodes a transcription factor for the regulation of body patterning in the embryo. Such inhibition was seen in the retinol- and retinal- induced, but not RA-induced, Hoxa1 up-regulation, indicating that the Corexit chemicals primarily inhibit RA biosynthesis from retinal. In addition, Corexit-EC9527A suppressed retinol-induced P19 cell differentiation into neuronal cells, indicating potential neurotoxic effect of the chemicals under the tested conditions. The surfactant ingredient, dioctyl sodium sulfosuccinate (DOSS), may be a major contributor to the observed effect of Corexit-EC9527A in the cell. JF - PloS one AU - Chen, Yanling AU - Reese, David H AD - Division of Molecular Biology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, 20708, United States of America. PY - 2016 SP - 1 VL - 11 IS - 9 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835523383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Corexit-EC9527A+Disrupts+Retinol+Signaling+and+Neuronal+Differentiation+in+P19+Embryonal+Pluripotent+Cells.&rft.au=Chen%2C+Yanling%3BReese%2C+David+H&rft.aulast=Chen&rft.aufirst=Yanling&rft.date=2016-01-01&rft.volume=11&rft.issue=9&rft.spage=e0163724&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0163724 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0163724 ER - TY - JOUR T1 - Application of Physiologically Based Absorption Modeling to Characterize the Pharmacokinetic Profiles of Oral Extended Release Methylphenidate Products in Adults. AN - 1835371470; 27723791 AB - A previously presented physiologically-based pharmacokinetic model for immediate release (IR) methylphenidate (MPH) was extended to characterize the pharmacokinetic behaviors of oral extended release (ER) MPH formulations in adults for the first time. Information on the anatomy and physiology of the gastrointestinal (GI) tract, together with the biopharmaceutical properties of MPH, was integrated into the original model, with model parameters representing hepatic metabolism and intestinal non-specific loss recalibrated against in vitro and in vivo kinetic data sets with IR MPH. A Weibull function was implemented to describe the dissolution of different ER formulations. A variety of mathematical functions can be utilized to account for the engineered release/dissolution technologies to achieve better model performance. The physiological absorption model tracked well the plasma concentration profiles in adults receiving a multilayer-release MPH formulation or Metadate CD, while some degree of discrepancy was observed between predicted and observed plasma concentration profiles for Ritalin LA and Medikinet Retard. A local sensitivity analysis demonstrated that model parameters associated with the GI tract significantly influenced model predicted plasma MPH concentrations, albeit to varying degrees, suggesting the importance of better understanding the GI tract physiology, along with the intestinal non-specific loss of MPH. The model provides a quantitative tool to predict the biphasic plasma time course data for ER MPH, helping elucidate factors responsible for the diverse plasma MPH concentration profiles following oral dosing of different ER formulations. JF - PloS one AU - Yang, Xiaoxia AU - Duan, John AU - Fisher, Jeffrey AD - National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America. ; Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 10 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1835371470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Application+of+Physiologically+Based+Absorption+Modeling+to+Characterize+the+Pharmacokinetic+Profiles+of+Oral+Extended+Release+Methylphenidate+Products+in+Adults.&rft.au=Yang%2C+Xiaoxia%3BDuan%2C+John%3BFisher%2C+Jeffrey&rft.aulast=Yang&rft.aufirst=Xiaoxia&rft.date=2016-01-01&rft.volume=11&rft.issue=10&rft.spage=e0164641&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0164641 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-10-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0164641 ER - TY - JOUR T1 - Evaluation of "Dream Herb," Calea zacatechichi , for Nephrotoxicity Using Human Kidney Proximal Tubule Cells AN - 1827914205; PQ0003719225 AB - A recent surge in the use of dietary supplements, including herbal remedies, necessitates investigations into their safety profiles. "Dream herb," Calea zacatechichi , has long been used in traditional folk medicine for a variety of purposes and is currently being marketed in the US for medicinal purposes, including diabetes treatment. Despite the inherent vulnerability of the renal system to xenobiotic toxicity, there is a lack of safety studies on the nephrotoxic potential of this herb. Additionally, the high frequency of diabetes-associated kidney disease makes safety screening of C. zacatechichi for safety especially important. We exposed human proximal tubule HK-2 cells to increasing doses of this herb alongside known toxicant and protectant control compounds to examine potential toxicity effects of C. zacatechichi relative to control compounds. We evaluated both cellular and mitochondrial functional changes related to toxicity of this dietary supplement and found that even at low doses evidence of cellular toxicity was significant. Moreover, these findings correlated with significantly elevated levels of nephrotoxicity biomarkers, lending further support for the need to further scrutinize the safety of this herbal dietary supplement. JF - Journal of Toxicology AU - Mossoba, Miriam E AU - Flynn, Thomas J AU - Vohra, Sanah AU - Wiesenfeld, Paddy AU - Sprando, Robert L AD - Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), US Food and Drug Administration (US FDA), Neurotoxicology and In Vitro Toxicology Branch (NIVTB), 8301 Muirkirk Road, Laurel, MD 20708, USA, miriam.mossoba@fda.hhs.gov Y1 - 2016/01// PY - 2016 DA - January 2016 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2016 SN - 1687-8191, 1687-8191 KW - Toxicology Abstracts; Environment Abstracts KW - Bioindicators KW - Dreams KW - Toxicants KW - Safety KW - Kidney diseases KW - Mitochondria KW - renal KW - Xenobiotics KW - Toxicity KW - biomarkers KW - Diabetes mellitus KW - Proximal tubules KW - Dietary supplements KW - Herbal medicines KW - Vulnerability KW - Herbs KW - X 24320:Food Additives & Contaminants KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827914205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology&rft.atitle=Evaluation+of+%22Dream+Herb%2C%22+Calea+zacatechichi+%2C+for+Nephrotoxicity+Using+Human+Kidney+Proximal+Tubule+Cells&rft.au=Mossoba%2C+Miriam+E%3BFlynn%2C+Thomas+J%3BVohra%2C+Sanah%3BWiesenfeld%2C+Paddy%3BSprando%2C+Robert+L&rft.aulast=Mossoba&rft.aufirst=Miriam&rft.date=2016-01-01&rft.volume=2016&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology&rft.issn=16878191&rft_id=info:doi/10.1155%2F2016%2F9794570 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 1 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Dreams; Toxicants; Proximal tubules; Dietary supplements; Herbal medicines; Kidney diseases; Mitochondria; Toxicity; biomarkers; Herbs; Bioindicators; Safety; Xenobiotics; renal; Vulnerability DO - http://dx.doi.org/10.1155/2016/9794570 ER - TY - JOUR T1 - Advancing toxicology research using in vivo high throughput toxicology with small fish models. AN - 1826701099; 27328013 AB - Small freshwater fish models, especially zebrafish, offer advantages over traditional rodent models, including low maintenance and husbandry costs, high fecundity, genetic diversity, physiology similar to that of traditional biomedical models, and reduced animal welfare concerns. The Collaborative Workshop on Aquatic Models and 21st Century Toxicology was held at North Carolina State University on May 5-6, 2014, in Raleigh, North Carolina, USA. Participants discussed the ways in which small fish are being used as models to screen toxicants and understand mechanisms of toxicity. Workshop participants agreed that the lack of standardized protocols is an impediment to broader acceptance of these models, whereas development of standardized protocols, validation, and subsequent regulatory acceptance would facilitate greater usage. Given the advantages and increasing application of small fish models, there was widespread interest in follow-up workshops to review and discuss developments in their use. In this article, we summarize the recommendations formulated by workshop participants to enhance the utility of small fish species in toxicology studies, as well as many of the advances in the field of toxicology that resulted from using small fish species, including advances in developmental toxicology, cardiovascular toxicology, neurotoxicology, and immunotoxicology. We alsoreview many emerging issues that will benefit from using small fish species, especially zebrafish, and new technologies that will enable using these organisms to yield results unprecedented in their information content to better understand how toxicants affect development and health. JF - ALTEX AU - Planchart, Antonio AU - Mattingly, Carolyn J AU - Allen, David AU - Ceger, Patricia AU - Casey, Warren AU - Hinton, David AU - Kanungo, Jyotshna AU - Kullman, Seth W AU - Tal, Tamara AU - Bondesson, Maria AU - Burgess, Shawn M AU - Sullivan, Con AU - Kim, Carol AU - Behl, Mamta AU - Padilla, Stephanie AU - Reif, David M AU - Tanguay, Robert L AU - Hamm, Jon AD - Department of Biological Sciences, North Carolina State University, Raleigh, NC, USA. ; Integrated Laboratory Systems, Inc., Research Triangle Park, NC, USA. ; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ; Nicholas School of the Environment, Duke University, Durham, NC, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA. ; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA. ; National Human Genome Research Institute, Bethesda, MD, USA. ; Department of Molecular & Biomedical Sciences, University of Maine, Orono, ME, USA. ; Division of National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ; Department of Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR, USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 435 EP - 452 VL - 33 IS - 4 SN - 1868-596X, 1868-596X KW - Hazardous Substances KW - 0 KW - Index Medicus KW - aquatic models KW - alternatives KW - 21st century toxicology KW - Animals KW - Humans KW - Whole Body Imaging KW - Cardiovascular Diseases -- chemically induced KW - Animals, Genetically Modified KW - Genome KW - Genomics KW - Fishes KW - Animal Experimentation KW - Toxicity Tests -- methods KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826701099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ALTEX&rft.atitle=Advancing+toxicology+research+using+in+vivo+high+throughput+toxicology+with+small+fish+models.&rft.au=Planchart%2C+Antonio%3BMattingly%2C+Carolyn+J%3BAllen%2C+David%3BCeger%2C+Patricia%3BCasey%2C+Warren%3BHinton%2C+David%3BKanungo%2C+Jyotshna%3BKullman%2C+Seth+W%3BTal%2C+Tamara%3BBondesson%2C+Maria%3BBurgess%2C+Shawn+M%3BSullivan%2C+Con%3BKim%2C+Carol%3BBehl%2C+Mamta%3BPadilla%2C+Stephanie%3BReif%2C+David+M%3BTanguay%2C+Robert+L%3BHamm%2C+Jon&rft.aulast=Planchart&rft.aufirst=Antonio&rft.date=2016-01-01&rft.volume=33&rft.issue=4&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=ALTEX&rft.issn=1868596X&rft_id=info:doi/10.14573%2Faltex.1601281 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-17 N1 - Date created - 2016-06-21 N1 - Date revised - 2017-01-30 N1 - Last updated - 2017-01-30 DO - http://dx.doi.org/10.14573/altex.1601281 ER - TY - JOUR T1 - High-protein meal challenge reveals the association between the salivary cortisol response and metabolic syndrome in police officers AN - 1815690537; PQ0002453314 AB - Objectives Policing is considered a high-stress occupation and officers have elevated cardiovascular morbidity and mortality. To investigate a potential connection, we evaluated the association between salivary cortisol response to a high-protein meal challenge and the metabolic syndrome (MetSyn), a subclinical disorder associated with increased cardiovascular risk. Methods Cross-sectional data were from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Study (2004-2009). MetSyn was defined as having greater than or equal to 3 components: abdominal obesity, hypertension, elevated triglycerides, reduced high-density lipoprotein cholesterol, and glucose intolerance. Officers provided five saliva samples for cortisol analysis, one before challenge (high-protein shake) and four at 15-min intervals thereafter, where the usual response is increase. Regression models were used to examine trends in mean number of MetSyn components across quartiles of area under the curve (AUC) salivary cortisol. Patterns of mean cortisol response were assessed by MetSyn status using repeated-measures analysis of covariance. Results Prevalence of MetSyn was 25.7% among 373 officers (74.0% male). The mean count of MetSyn components decreased (1.89, 1.75, 1.55, 1.37; P<0.01) across increasing quartiles of AUC salivary cortisol. Mean salivary cortisol decreased from baseline (5.55, 4.58, 4.47, 4.79, 4.75 nmol/l) in officers with MetSyn and increased (5.08, 5.82, 5.92, 5.82, 5.60 nmol/l) in their counterparts. The test for interaction between MetSyn status and time of saliva collection was statistically significant (P<0.001). Conclusions Reduced cortisol response to a high-protein meal challenge may be associated with MetSyn. Future longitudinal studies could provide useful evidence for planning intervention studies on cardiovascular risk among police officers. Am. J. Hum. Biol. 28:138-144, 2016. JF - American Journal of Human Biology AU - Baughman, Penelope AU - Andrew, Michael E AU - Burchfiel, Cecil M AU - Fekedulegn, Desta AU - Hartley, Tara A AU - Violanti, John M AU - Miller, Diane B AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 138 EP - 144 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 28 IS - 1 SN - 1042-0533, 1042-0533 KW - Toxicology Abstracts KW - Obesity KW - Mortality KW - Data processing KW - Hydrocortisone KW - Metabolic disorders KW - Statistical analysis KW - Stress KW - Cholesterol KW - Morbidity KW - Models KW - Triglycerides KW - Lipoproteins KW - Regression analysis KW - Glucose tolerance KW - Saliva KW - Cardiovascular diseases KW - Hypertension KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1815690537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Human+Biology&rft.atitle=High-protein+meal+challenge+reveals+the+association+between+the+salivary+cortisol+response+and+metabolic+syndrome+in+police+officers&rft.au=Baughman%2C+Penelope%3BAndrew%2C+Michael+E%3BBurchfiel%2C+Cecil+M%3BFekedulegn%2C+Desta%3BHartley%2C+Tara+A%3BViolanti%2C+John+M%3BMiller%2C+Diane+B&rft.aulast=Baughman&rft.aufirst=Penelope&rft.date=2016-01-01&rft.volume=28&rft.issue=1&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Human+Biology&rft.issn=10420533&rft_id=info:doi/10.1002%2Fajhb.22748 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Mortality; Obesity; Hydrocortisone; Data processing; Metabolic disorders; Statistical analysis; Stress; Cholesterol; Morbidity; Models; Triglycerides; Lipoproteins; Regression analysis; Glucose tolerance; Cardiovascular diseases; Saliva; Hypertension DO - http://dx.doi.org/10.1002/ajhb.22748 ER - TY - JOUR T1 - Impact of Screening Implementing HCV Screening of Persons Born 1945-1965 AN - 1811926257 AB - Background: In August 2012, the Centers for Disease Control and Prevention released recommendations to screen persons born from 1945 to 1965 for hepatitis C virus (HCV). In September 2012, Warm Springs Health and Wellness Center (WSHWC) initiated a quality improvement (QI) project to conduct HCV screening among all patients in this birth cohort. Methods: Screening rates were tracked using a nationally standardized HCV screening measure in the Indian Health Service. At the end of the project period, WSHWC staff took a brief survey to review the impact of the HCV QI Project. Results: Screening for HCV among eligible patients at WSHWC increased from 5% (47/938) in September 2012 to 76% (593/785) in September 2014. Survey data indicated that clinicians felt increased screening for HCV had a positive impact on patient communication and care. Conclusions: Primary care clinics can successfully increase HCV screening in a relatively short time period. Age based screening recommendation may provide opportunities to increase communication with others at risk for HCV. As more patients are screened, it will be important to ensure appropriate linkage to care for HCV patients. JF - Journal of Primary Care & Community Health AU - Gemelas, James AU - Locker, Rachel AU - Rudd, Stephen AU - Prevost, Carol AU - Reilley, Brigg AU - Leston, Jessica AD - Warm Springs Health and Wellness Center (WSHWC), Warm Springs, OR, USA ; Indian Health Service, Portland Area Office, Portland, OR, USA ; Indian Health Service, Albuquerque, NM, USA ; Northwest Portland Area Indian Health Board, Portland, OR, USA ; Warm Springs Health and Wellness Center (WSHWC), Warm Springs, OR, USA Y1 - 2016/01// PY - 2016 DA - Jan 2016 SP - 30 EP - 32 CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 7 IS - 1 SN - 2150-1319 KW - Medical Sciences KW - primary care KW - quality improvement KW - rural health KW - medical informatics KW - impact evaluation KW - community health KW - access to care KW - At risk KW - Childbirth KW - Communication KW - Health services KW - Hepatitis KW - Hepatitis C KW - Patient care KW - Primary health care KW - Quality management KW - Screening KW - Surveys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811926257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Primary+Care+%26+Community+Health&rft.atitle=Impact+of+Screening+Implementing+HCV+Screening+of+Persons+Born+1945-1965&rft.au=Gemelas%2C+James%3BLocker%2C+Rachel%3BRudd%2C+Stephen%3BPrevost%2C+Carol%3BReilley%2C+Brigg%3BLeston%2C+Jessica&rft.aulast=Gemelas&rft.aufirst=James&rft.date=2016-01-01&rft.volume=7&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Journal+of+Primary+Care+%26+Community+Health&rft.issn=21501319&rft_id=info:doi/10.1177%2F2150131915602020 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Centers for Disease Control & Prevention--CDC; Indian Health Service N1 - Copyright - © The Author(s) 2015 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1177/2150131915602020 ER - TY - JOUR T1 - Spectroscopic-Based Chemometric Models for Quantifying Low Levels of Solid-State Transitions in Extended Release Theophylline Formulations: Pharmaceutics, Drug Delivery and Pharmaceutical Technology AN - 1811903808; PQ0003310928 AB - Variations in the solid state form of a pharmaceutical solid have profound impact on the product quality and clinical performance. Quantitative models that allow rapid and accurate determination of polymorphic changes in pharmaceutical products are essential in ensuring product quality throughout its lifecycle. This study reports the development and validation of chemometric models of Raman and near infrared spectroscopy (NIR) for quantifying the extent of pseudopolymorphic transitions of theophylline in extended release formulations. The chemometric models were developed using sample matrices consisting of the commonly used excipients and at the ratios in commercially available products. A combination of scatter removal (multiplicative signal correction and standard normal variate) and derivatization (Savitzky-Golay second derivative) algorithm were used for data pretreatment. Partial least squares and principal component regression models were developed and their performance assessed. Diagnostic statistics such as the root mean square error, correlation coefficient, bias and Q2 were used as parameters to test the model fit and performance. The models developed had a good fit and performance as shown by the values of the diagnostic statistics. The model diagnostic statistics were similar for MSC-SG and SNV-SG treated spectra. Similarly, PLSR and PCR models had comparable performance. Raman chemometric models were slightly better than their corresponding NIR model. The Raman and NIR chemometric models developed had good accuracy and precision as demonstrated by closeness of the predicted values for the independent observations to the actual TMO content hence the developed models can serve as useful tools in quantifying and controlling solid state transitions in extended release theophylline products. JF - Journal of Pharmaceutical Sciences AU - Korang-Yeboah, Maxwell AU - Rahman, Ziyaur AU - Shah, Dhaval A AU - Khan, Mansoor A AD - Division of Product Quality and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland 20993 Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 97 EP - 105 PB - Elsevier Science Ltd., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 105 IS - 1 SN - 0022-3549, 0022-3549 KW - Biotechnology and Bioengineering Abstracts KW - chemometrics KW - controlled release KW - partial least squares KW - formulation KW - near-infrared spectroscopy KW - Raman spectroscopy KW - pseudopolymorph KW - solid state stability KW - Drug delivery KW - Statistics KW - Data processing KW - I.R. spectroscopy KW - Statistical analysis KW - Algorithms KW - Regression analysis KW - Pharmaceuticals KW - Polymerase chain reaction KW - Theophylline KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811903808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Spectroscopic-Based+Chemometric+Models+for+Quantifying+Low+Levels+of+Solid-State+Transitions+in+Extended+Release+Theophylline+Formulations%3A+Pharmaceutics%2C+Drug+Delivery+and+Pharmaceutical+Technology&rft.au=Korang-Yeboah%2C+Maxwell%3BRahman%2C+Ziyaur%3BShah%2C+Dhaval+A%3BKhan%2C+Mansoor+A&rft.aulast=Korang-Yeboah&rft.aufirst=Maxwell&rft.date=2016-01-01&rft.volume=105&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1016%2Fj.xphs.2015.11.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Number of references - 31 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Drug delivery; Data processing; Statistics; I.R. spectroscopy; Regression analysis; Algorithms; Statistical analysis; Polymerase chain reaction; Pharmaceuticals; Theophylline DO - http://dx.doi.org/10.1016/j.xphs.2015.11.007 ER - TY - JOUR T1 - Epidemiologic characteristics,risk factors and safety evaluation of traditional Chinese medicine induced liver injury AN - 1808609995; PQ0003477955 AB - There have been increasing reports on liver injury induced by traditional Chinese medicine(TCM)and natural medicine in recent years. The risk of liver injury induced by TCMs has attracted more attention at home and abroad. In this paper,epidemiologic characteristics,risk factors,clinical features of TCMs induced liver injury were discussed. The myth about research and safety evaluation of TCMs induced liver injury was analyzed. Based on the property of TCMs and characteristics of their clinical use,this paper proposed the priorities of basic and clinical safety evaluation of TCMs induced liver toxicity. It is hoped that this study may provide reference for scientific evaluation of liver toxicity of TCMs. JF - Zhongguo Yaolixue yu Dulixue Zazhi - Chinese Journal of Pharmacology and Toxicology AU - Song, Hai-bo AU - Han, Ling AD - Center for Drug Reevaluation,China Food and Drug Administration,Beijing 100045,China, songhiabo@cdr-adr.org.cn Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 291 EP - 305 PB - Zhongguo Duli Xuehui VL - 30 IS - 4 SN - 1000-3002, 1000-3002 KW - Toxicology Abstracts KW - traditional Chinese medicine KW - drug induced liver injury KW - risk factors KW - safety evaluation KW - Injuries KW - Liver KW - Toxicity KW - Traditional Chinese Medicine KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808609995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zhongguo+Yaolixue+yu+Dulixue+Zazhi+-+Chinese+Journal+of+Pharmacology+and+Toxicology&rft.atitle=Epidemiologic+characteristics%2Crisk+factors+and+safety+evaluation+of+traditional+Chinese+medicine+induced+liver+injury&rft.au=Song%2C+Hai-bo%3BHan%2C+Ling&rft.aulast=Song&rft.aufirst=Hai-bo&rft.date=2016-01-01&rft.volume=30&rft.issue=4&rft.spage=291&rft.isbn=&rft.btitle=&rft.title=Zhongguo+Yaolixue+yu+Dulixue+Zazhi+-+Chinese+Journal+of+Pharmacology+and+Toxicology&rft.issn=10003002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Injuries; Liver; Toxicity; Traditional Chinese Medicine ER - TY - JOUR T1 - Species Identification of Food Contaminating Beetles by Recognizing Patterns in Microscopic Images of Elytra Fragments. AN - 1800129612; 27341524 AB - A crucial step of food contamination inspection is identifying the species of beetle fragments found in the sample, since the presence of some storage beetles is a good indicator of insanitation or potential food safety hazards. The current pratice, visual examination by human analysts, is time consuming and requires several years of experience. Here we developed a species identification algorithm which utilizes images of microscopic elytra fragments. The elytra, or hardened forewings, occupy a large portion of the body, and contain distinctive patterns. In addition, elytra fragments are more commonly recovered from processed food products than other body parts due to their hardness. As a preliminary effort, we chose 15 storage product beetle species frequently detected in food inspection. The elytra were then separated from the specimens and imaged under a microscope. Both global and local characteristics were quantified and used as feature inputs to artificial neural networks for species classification. With leave-one-out cross validation, we achieved overall accuracy of 80% through the proposed global and local features, which indicates that our proposed features could differentiate these species. Through examining the overall and per species accuracies, we further demonstrated that the local features are better suited than the global features for species identification. Future work will include robust testing with more beetle species and algorithm refinement for a higher accuracy. JF - PloS one AU - Park, Su Inn AU - Bisgin, Halil AU - Ding, Hongjian AU - Semey, Howard G AU - Langley, Darryl A AU - Tong, Weida AU - Xu, Joshua AD - Department of Computer Science, Texas A&M University, College Station, Texas, United States of America. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America. ; Arkansas Regional Laboratories, Office for Regulatory Affairs, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 6 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1800129612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Species+Identification+of+Food+Contaminating+Beetles+by+Recognizing+Patterns+in+Microscopic+Images+of+Elytra+Fragments.&rft.au=Park%2C+Su+Inn%3BBisgin%2C+Halil%3BDing%2C+Hongjian%3BSemey%2C+Howard+G%3BLangley%2C+Darryl+A%3BTong%2C+Weida%3BXu%2C+Joshua&rft.aulast=Park&rft.aufirst=Su&rft.date=2016-01-01&rft.volume=11&rft.issue=6&rft.spage=e0157940&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0157940 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Erratum In: PLoS One. 2016;11(9):e0162757 [27603930] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0157940 ER - TY - JOUR T1 - Emission of particulate matter from a desktop three-dimensional (3D) printer. AN - 1795865712; 27196745 AB - Desktop three-dimensional (3D) printers are becoming commonplace in business offices, public libraries, university labs and classrooms, and even private homes; however, these settings are generally not designed for exposure control. Prior experience with a variety of office equipment devices such as laser printers that emit ultrafine particles (UFP) suggests the need to characterize 3D printer emissions to enable reliable risk assessment. The aim of this study was to examine factors that influence particulate emissions from 3D printers and characterize their physical properties to inform risk assessment. Emissions were evaluated in a 0.5-m(3) chamber and in a small room (32.7 m(3)) using real-time instrumentation to measure particle number, size distribution, mass, and surface area. Factors evaluated included filament composition and color, as well as the manufacturer-provided printer emissions control technologies while printing an object. Filament type significantly influenced emissions, with acrylonitrile butadiene styrene (ABS) emitting larger particles than polylactic acid (PLA), which may have been the result of agglomeration. Geometric mean particle sizes and total particle (TP) number and mass emissions differed significantly among colors of a given filament type. Use of a cover on the printer reduced TP emissions by a factor of 2. Lung deposition calculations indicated a threefold higher PLA particle deposition in alveoli compared to ABS. Desktop 3D printers emit high levels of UFP, which are released into indoor environments where adequate ventilation may not be present to control emissions. Emissions in nonindustrial settings need to be reduced through the use of a hierarchy of controls, beginning with device design, followed by engineering controls (ventilation) and administrative controls such as choice of filament composition and color. JF - Journal of toxicology and environmental health. Part A AU - Yi, Jinghai AU - LeBouf, Ryan F AU - Duling, Matthew G AU - Nurkiewicz, Timothy AU - Chen, Bean T AU - Schwegler-Berry, Diane AU - Virji, M Abbas AU - Stefaniak, Aleksandr B AD - a Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology , West Virginia University School of Medicine , Morgantown , West Virginia , USA. ; b National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 453 EP - 465 VL - 79 IS - 11 SN - 1528-7394, 1528-7394 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795865712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Emission+of+particulate+matter+from+a+desktop+three-dimensional+%283D%29+printer.&rft.au=Yi%2C+Jinghai%3BLeBouf%2C+Ryan+F%3BDuling%2C+Matthew+G%3BNurkiewicz%2C+Timothy%3BChen%2C+Bean+T%3BSchwegler-Berry%2C+Diane%3BVirji%2C+M+Abbas%3BStefaniak%2C+Aleksandr+B&rft.aulast=Yi&rft.aufirst=Jinghai&rft.date=2016-01-01&rft.volume=79&rft.issue=11&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2016.1166467 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15287394.2016.1166467 ER - TY - JOUR T1 - Multiwalled carbon nanotube-induced pulmonary inflammatory and fibrotic responses and genomic changes following aspiration exposure in mice: A 1-year postexposure study. AN - 1795862953; 27092743 AB - Pulmonary exposure to multiwalled carbon nanotubes (MWCNT) induces an inflammatory and rapid fibrotic response, although the long-term signaling mechanisms are unknown. The aim of this study was to examine the effects of 1, 10, 40, or 80 μg MWCNT administered by pharyngeal aspiration on bronchoalveolar lavage (BAL) fluid for polymorphonuclear cell (PMN) infiltration, lactate dehydrogenase (LDH) activity, and lung histopathology for inflammatory and fibrotic responses in mouse lungs 1 mo, 6 mo, and 1 yr postexposure. Further, a 120-μg crocidolite asbestos group was incorporated as a positive control for comparative purposes. Results showed that MWCNT increased BAL fluid LDH activity and PMN infiltration in a dose-dependent manner at all three postexposure times. Asbestos exposure elevated LDH activity at all 3 postexposure times and PMN infiltration at 1 mo and 6 mo postexposure. Pathological changes in the lung, the presence of MWCNT or asbestos, and fibrosis were noted at 40 and 80 μg MWCNT and in asbestos-exposed mice at 1 yr postexposure. To determine potential signaling pathways involved with MWCNT-associated pathological changes in comparison to asbestos, up- and down-regulated gene expression was determined in lung tissue at 1 yr postexposure. Exposure to MWCNT tended to favor those pathways involved in immune responses, specifically T-cell responses, whereas exposure to asbestos tended to favor pathways involved in oxygen species production, electron transport, and cancer. Data indicate that MWCNT are biopersistent in the lung and induce inflammatory and fibrotic pathological alterations similar to those of crocidolite asbestos, but may reach these endpoints by different mechanisms. JF - Journal of toxicology and environmental health. Part A AU - Snyder-Talkington, Brandi N AU - Dong, Chunlin AU - Porter, Dale W AU - Ducatman, Barbara AU - Wolfarth, Michael G AU - Andrew, Michael AU - Battelli, Lori AU - Raese, Rebecca AU - Castranova, Vincent AU - Guo, Nancy L AU - Qian, Yong AD - a Pathology and Physiology Research Branch, Health Effects Laboratory Division , National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA. ; b Mary Babb Randolph Cancer Center , West Virginia University , Morgantown , West Virginia , USA. ; c Department of Pathology , West Virginia University , Morgantown , West Virginia , USA. ; d Department of Pharmaceutical Sciences , School of Pharmacy, West Virginia University , Morgantown , West Virginia , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 352 EP - 366 VL - 79 IS - 8 SN - 1528-7394, 1528-7394 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1795862953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Multiwalled+carbon+nanotube-induced+pulmonary+inflammatory+and+fibrotic+responses+and+genomic+changes+following+aspiration+exposure+in+mice%3A+A+1-year+postexposure+study.&rft.au=Snyder-Talkington%2C+Brandi+N%3BDong%2C+Chunlin%3BPorter%2C+Dale+W%3BDucatman%2C+Barbara%3BWolfarth%2C+Michael+G%3BAndrew%2C+Michael%3BBattelli%2C+Lori%3BRaese%2C+Rebecca%3BCastranova%2C+Vincent%3BGuo%2C+Nancy+L%3BQian%2C+Yong&rft.aulast=Snyder-Talkington&rft.aufirst=Brandi&rft.date=2016-01-01&rft.volume=79&rft.issue=8&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2016.1159635 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-06-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15287394.2016.1159635 ER - TY - JOUR T1 - Generalized Additive Mixed-Models for Pharmacology Using Integrated Discrete Multiple Organ Co-Culture. AN - 1784749720; 27110941 AB - Integrated Discrete Multiple Organ Co-culture (IDMOC) is emerging as an in-vitro alternative to in-vivo animal models for pharmacology studies. IDMOC allows dose-response relationships to be investigated at the tissue and organoid levels, yet, these relationships often exhibit responses that are far more complex than the binary responses often measured in whole animals. To accommodate departure from binary endpoints, IDMOC requires an expansion of analytic techniques beyond simple linear probit and logistic models familiar in toxicology. IDMOC dose-responses may be measured at continuous scales, exhibit significant non-linearity such as local maxima or minima, and may include non-independent measures. Generalized additive mixed-modeling (GAMM) provides an alternative description of dose-response that relaxes assumptions of independence and linearity. We compared GAMMs to traditional linear models for describing dose-response in IDMOC pharmacology studies. JF - PloS one AU - Ingersoll, Thomas AU - Cole, Stephanie AU - Madren-Whalley, Janna AU - Booker, Lamont AU - Dorsey, Russell AU - Li, Albert AU - Salem, Harry AD - Defense Threat Reduction Agency, Joint CBRN Center of Excellence, Aberdeen Proving Ground, Maryland, United States of America. ; US Army Research, Development, and Engineering Command, Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland, United States of America. ; Food and Drug Administration, Silver Spring, Maryland, United States of America. ; In Vitro ADMET Laboratories, Columbia, Maryland, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 4 KW - Index Medicus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1784749720?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Generalized+Additive+Mixed-Models+for+Pharmacology+Using+Integrated+Discrete+Multiple+Organ+Co-Culture.&rft.au=Ingersoll%2C+Thomas%3BCole%2C+Stephanie%3BMadren-Whalley%2C+Janna%3BBooker%2C+Lamont%3BDorsey%2C+Russell%3BLi%2C+Albert%3BSalem%2C+Harry&rft.aulast=Ingersoll&rft.aufirst=Thomas&rft.date=2016-01-01&rft.volume=11&rft.issue=4&rft.spage=e0152985&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0152985 LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2016-04-26 N1 - Date revised - 2017-02-15 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2000 Aug;28(8):880-6 [10901695] Acta Pharmacol Toxicol (Copenh). 1972;31(1):153-60 [4336918] Can J Comp Med. 1981 Jan;45(1):60-9 [7272842] Cancer Res. 1987 May 15;47(10):2723-6 [3552204] Toxicol Appl Pharmacol. 1993 Jun;120(2):240-6 [8511793] Clin Cancer Res. 1995 Oct;1(10):1171-7 [9815909] J Biomol Screen. 2014 Dec;19(10):1402-8 [25239051] Pharmacogenomics J. 2008 Feb;8(1):29-33 [17339877] Toxicol Appl Pharmacol. 2011 Jul 15;254(2):181-91 [21034758] ALTEX. 2012;29(1):3-91 [22307314] Chem Biol Interact. 2012 Jul 30;199(1):1-8 [22640811] Toxicol Appl Pharmacol. 2014 Jan 1;274(1):124-36 [24211272] J Pharmacol Exp Ther. 1952 Apr;104(4):440-4 [14918065] N1 - Last updated - 2017-02-15 DO - http://dx.doi.org/10.1371/journal.pone.0152985 ER - TY - JOUR T1 - Mercapturic acids: recent advances in their determination by liquid chromatography/mass spectrometry and their use in toxicant metabolism studies and in occupational and environmental exposure studies. AN - 1783908869; 26900903 AB - This review describes recent selected HPLC/MS methods for the determination of urinary mercapturates that are useful as noninvasive biomarkers in characterizing human exposure to electrophilic industrial chemicals in occupational and environmental studies. High-performance liquid chromatography/mass spectrometry is a sensitive and specific method for analysis of small molecules found in biological fluids. In this review, recent selected mercapturate quantification methods are summarized and specific cases are presented. The biological formation of mercapturates is introduced and their use as indicators of metabolic processing of reactive toxicants is discussed, as well as future trends and limitations in this area of research. JF - Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals AU - Mathias, Patricia I AU - B'hymer, Clayton AD - a Division of Applied Science and Technology , U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Biomonitoring and Health Assessment Branch, Robert a. Taft Laboratories , Cincinnati , OH , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 293 EP - 315 VL - 21 IS - 4 KW - Biomarkers KW - 0 KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - liquid chromatography KW - Internal exposure KW - urinary biomarker KW - mass spectrometry KW - toxicant metabolism KW - mercapturic acid KW - Humans KW - Occupational Exposure KW - Biomarkers -- analysis KW - Acetylcysteine -- analysis KW - Environmental Exposure KW - Chromatography, High Pressure Liquid -- methods KW - Acetylcysteine -- metabolism KW - Mass Spectrometry -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1783908869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+%3A+biochemical+indicators+of+exposure%2C+response%2C+and+susceptibility+to+chemicals&rft.atitle=Mercapturic+acids%3A+recent+advances+in+their+determination+by+liquid+chromatography%2Fmass+spectrometry+and+their+use+in+toxicant+metabolism+studies+and+in+occupational+and+environmental+exposure+studies.&rft.au=Mathias%2C+Patricia+I%3BB%27hymer%2C+Clayton&rft.aulast=Mathias&rft.aufirst=Patricia&rft.date=2016-01-01&rft.volume=21&rft.issue=4&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Biomarkers+%3A+biochemical+indicators+of+exposure%2C+response%2C+and+susceptibility+to+chemicals&rft.issn=1366-5804&rft_id=info:doi/10.3109%2F1354750X.2016.1141988 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-02-09 N1 - Date created - 2016-04-22 N1 - Date revised - 2017-02-13 N1 - Last updated - 2017-02-13 DO - http://dx.doi.org/10.3109/1354750X.2016.1141988 ER - TY - JOUR T1 - Fluorescent Receptor Binding Assay for Detecting Ciguatoxins in Fish. AN - 1781536257; 27073998 AB - Ciguatera fish poisoning is an illness suffered by > 50,000 people yearly after consumption of fish containing ciguatoxins (CTXs). One of the current methodologies to detect ciguatoxins in fish is a radiolabeled receptor binding assay (RBA(R)). However, the license requirements and regulations pertaining to radioisotope utilization can limit the applicability of the RBA(R) in certain labs. A fluorescence based receptor binding assay (RBA(F)) was developed to provide an alternative method of screening fish samples for CTXs in facilities not certified to use radioisotopes. The new assay is based on competition binding between CTXs and fluorescently labeled brevetoxin-2 (BODIPY®-PbTx-2) for voltage-gated sodium channel receptors at site 5 instead of a radiolabeled brevetoxin. Responses were linear in fish tissues spiked from 0.1 to 1.0 ppb with Pacific ciguatoxin-3C (P-CTX-3C) with a detection limit of 0.075 ppb. Carribean ciguatoxins were confirmed in Caribbean fish by LC-MS/MS analysis of the regional biomarker (C-CTX-1). Fish (N = 61) of six different species were screened using the RBA(F). Results for corresponding samples analyzed using the neuroblastoma cell-based assay (CBA-N2a) correlated well (R2 = 0.71) with those of the RBA(F), given the low levels of CTX present in positive fish. Data analyses also showed the resulting toxicity levels of P-CTX-3C equivalents determined by CBA-N2a were consistently lower than the RBA(F) affinities expressed as % binding equivalents, indicating that a given amount of toxin bound to the site 5 receptors translates into corresponding lower cytotoxicity. Consequently, the RBA(F), which takes approximately two hours to perform, provides a generous estimate relative to the widely used CBA-N2a which requires 2.5 days to complete. Other RBA(F) advantages include the long-term (> 5 years) stability of the BODIPY®-PbTx-2 and having similar results as the commonly used RBA(R). The RBA(F) is cost-effective, allows high sample throughput, and is well-suited for routine CTX monitoring programs. JF - PloS one AU - Hardison, D Ransom AU - Holland, William C AU - McCall, Jennifer R AU - Bourdelais, Andrea J AU - Baden, Daniel G AU - Darius, H Taiana AU - Chinain, Mireille AU - Tester, Patricia A AU - Shea, Damian AU - Quintana, Harold A Flores AU - Morris, James A AU - Litaker, R Wayne AD - National Oceanic and Atmospheric Administration, Center for Coastal Fisheries and Habitat Research, Beaufort, North Carolina, United States of America. ; University of North Carolina at Wilmington, MARBIONC at CREST Research Park, Wilmington, North Carolina, United States of America. ; Institut Louis Malardé (ILM)-UMR 241 EIO, Laboratory of Toxic-Microalgae, Papeete, Tahiti, French Polynesia. ; North Carolina State University, Environmental Chemistry and Toxicology Laboratory, Raleigh, North Carolina, United States of America. ; U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 4 KW - Ciguatoxins KW - 11050-21-8 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Chromatography, Liquid KW - Tandem Mass Spectrometry KW - Protein Binding KW - Synaptosomes -- metabolism KW - Ciguatoxins -- isolation & purification KW - Ciguatera Poisoning -- diagnosis KW - Fishes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1781536257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Fluorescent+Receptor+Binding+Assay+for+Detecting+Ciguatoxins+in+Fish.&rft.au=Hardison%2C+D+Ransom%3BHolland%2C+William+C%3BMcCall%2C+Jennifer+R%3BBourdelais%2C+Andrea+J%3BBaden%2C+Daniel+G%3BDarius%2C+H+Taiana%3BChinain%2C+Mireille%3BTester%2C+Patricia+A%3BShea%2C+Damian%3BQuintana%2C+Harold+A+Flores%3BMorris%2C+James+A%3BLitaker%2C+R+Wayne&rft.aulast=Hardison&rft.aufirst=D&rft.date=2016-01-01&rft.volume=11&rft.issue=4&rft.spage=e0153348&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0153348 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-09 N1 - Date created - 2016-04-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J AOAC Int. 2001 Sep-Oct;84(5):1617-25 [11601484] Ther Drug Monit. 2000 Feb;22(1):61-4 [10688261] Am J Trop Med Hyg. 1979 Nov;28(6):1067-73 [574366] Mol Pharmacol. 1986 Aug;30(2):129-35 [2426567] FEBS Lett. 1987 Jul 27;219(2):355-9 [2440718] Anal Biochem. 1993 Oct;214(1):190-4 [8250223] Nat Toxins. 1994;2(4):189-96 [7952943] J Neurosci Res. 1999 Mar 15;55(6):666-73 [10220108] Toxicon. 2005 Sep 1;46(3):261-70 [15982699] Toxicon. 2007 Jan;49(1):100-5 [17113119] Toxicon. 2007 Oct;50(5):612-26 [17631928] Toxicon. 2010 Aug 15;56(2):123-36 [19782098] Mar Drugs. 2010;8(6):1838-907 [20631873] Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(6):1000-10 [22394180] Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(3):567-86 [23286347] J AOAC Int. 2014 Mar-Apr;97(2):307-15 [24830141] Toxicon. 2015 Aug;102:62-8 [26026621] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0153348 ER - TY - JOUR T1 - Long-term daily vibration exposure alters current perception threshold (CPT) sensitivity and myelinated axons in a rat-tail model of vibration-induced injury AN - 1780525891; PQ0002884885 AB - Repeated exposure to hand-transmitted vibration through the use of powered hand tools may result in pain and progressive reductions in tactile sensitivity. The goal of the present study was to use an established animal model of vibration-induced injury to characterize changes in sensory nerve function and cellular mechanisms associated with these alterations. Sensory nerve function was assessed weekly using the current perception threshold test and tail-flick analgesia test in male Sprague-Dawley rats exposed to 28 d of tail vibration. After 28 d of exposure, A beta fiber sensitivity was reduced. This reduction in sensitivity was partly attributed to structural disruption of myelin. In addition, the decrease in sensitivity was also associated with a reduction in myelin basic protein and 2',3'- cyclic nucleotide phosphodiasterase (CNPase) staining in tail nerves, and an increase in circulating calcitonin gene-related peptide (CGRP) concentrations. Changes in A beta fiber sensitivity and CGRP concentrations may serve as early markers of vibration-induced injury in peripheral nerves. It is conceivable that these markers may be utilized to monitor sensorineural alterations in workers exposed to vibration to potentially prevent additional injury. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Krajnak, Kristine AU - Raju, Sandya G AU - Miller, GRoger AU - Johnson, Claud AU - Waugh, Stacey AU - Kashon, Michael L AU - Riley, Danny A AD - Engineering and Control Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2016///0, PY - 2016 DA - 0, 2016 SP - 101 EP - 111 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 79 IS - 3 SN - 1528-7394, 1528-7394 KW - CSA Neurosciences Abstracts; Pollution Abstracts; Environment Abstracts; Toxicology Abstracts KW - Calcitonin gene-related peptide KW - Injuries KW - Animal models KW - Cyclic nucleotides KW - Pain KW - Rats KW - Analgesia KW - Occupational exposure KW - Sensitivity KW - Sensory neurons KW - Myelin KW - Tails KW - Pain perception KW - Hand KW - Vibrations KW - Fibers KW - Antibodies KW - Perception KW - Vibration KW - Proteins KW - Axons KW - Peripheral nerves KW - Myelin basic protein KW - Hand tools KW - N3 11028:Neuropharmacology & toxicology KW - X 24360:Metals KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780525891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Long-term+daily+vibration+exposure+alters+current+perception+threshold+%28CPT%29+sensitivity+and+myelinated+axons+in+a+rat-tail+model+of+vibration-induced+injury&rft.au=Krajnak%2C+Kristine%3BRaju%2C+Sandya+G%3BMiller%2C+GRoger%3BJohnson%2C+Claud%3BWaugh%2C+Stacey%3BKashon%2C+Michael+L%3BRiley%2C+Danny+A&rft.aulast=Krajnak&rft.aufirst=Kristine&rft.date=2016-01-01&rft.volume=79&rft.issue=3&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2015.1104272 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Calcitonin gene-related peptide; Myelin; Injuries; Sensory neurons; Tails; Pain perception; Animal models; Cyclic nucleotides; Hand; Vibrations; Fibers; Antibodies; Analgesia; Perception; Axons; Myelin basic protein; Peripheral nerves; Rats; Sensitivity; Vibration; Proteins; Pain; Occupational exposure; Hand tools DO - http://dx.doi.org/10.1080/15287394.2015.1104272 ER - TY - JOUR T1 - Culture-Independent Rapid Detection Methods for Bacterial Pathogens and Toxins in Food Matrices AN - 1780512270; PQ0002771628 AB - Rapid detection of bacterial pathogens and toxins in foods is necessary to provide real-time results to mitigate foodborne illness outbreaks. Cultural enrichment methods, although the most widely used, are time-consuming and therefore inadequate for rapid pathogen detection from food samples. The development of novel "rapid" detection methods has decreased detection time dramatically. This review presents an overview of detection methods for various foodborne pathogens, including Listeria monocytogenes, Salmonella enterica, and shiga toxin-producing Escherichia coli, and bacterial toxins in food matrices, with emphasis on those methods which do not require cultural enrichment. Discussed methods include nucleic acid-, immunological-, and biosensor-based techniques. A summary of each type of detection method is given, including referenced methods from the literature. Since these discussed methods do not require cultural enrichment, there is a higher probability of interference from the food matrices. Therefore, the review also discusses the potential interference of food components on detection methods and addresses preprocessing strategies to overcome matrix associated inhibition and to concentrate low quantities of pathogens and toxins in food. Development of rapid and sensitive detection technologies advances and ensures public health safety and security. JF - Comprehensive Reviews in Food Science and Food Safety AU - Wang, Yun AU - Salazar, Joelle K AD - Div. of Food Processing Science and Technology, U.S. Food and Drug Administration, Bedford Park, IL, U.S.A. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 183 EP - 205 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 15 IS - 1 SN - 1541-4337, 1541-4337 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Listeria monocytogenes KW - Salmonella enterica KW - Food KW - Reviews KW - Escherichia coli KW - Pathogens KW - Toxins KW - Public health KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780512270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+Reviews+in+Food+Science+and+Food+Safety&rft.atitle=Culture-Independent+Rapid+Detection+Methods+for+Bacterial+Pathogens+and+Toxins+in+Food+Matrices&rft.au=Wang%2C+Yun%3BSalazar%2C+Joelle+K&rft.aulast=Wang&rft.aufirst=Yun&rft.date=2016-01-01&rft.volume=15&rft.issue=1&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Comprehensive+Reviews+in+Food+Science+and+Food+Safety&rft.issn=15414337&rft_id=info:doi/10.1111%2F1541-4337.12175 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Reviews; Food; Pathogens; Toxins; Public health; Listeria monocytogenes; Salmonella enterica; Escherichia coli DO - http://dx.doi.org/10.1111/1541-4337.12175 ER - TY - JOUR T1 - Lack of Correlation between Stem-Cell Proliferation and Radiation- or Smoking-Associated Cancer Risk. AN - 1778709163; 27031507 AB - A recent paper by Tomasetti and Vogelstein (Science 2015 347 78-81) suggested that the variation in natural cancer risk was largely explained by the total number of stem-cell divisions, and that most cancers arose by chance. They proposed an extra-risk score as way of distinguishing the effects of the stochastic, replicative component of cancer risk from other causative factors, specifically those due to the external environment and inherited mutations. We tested the hypothesis raised by Tomasetti and Vogelstein by assessing the degree of correlation of stem cell divisions and their extra-risk score with radiation- and tobacco-associated cancer risk. We fitted a variety of linear and log-linear models to data on stem cell divisions per year and cumulative stem cell divisions over lifetime and natural cancer risk, some taken from the paper of Tomasetti and Vogelstein, augmented using current US lifetime cancer risk data, and also radiation- and tobacco-associated cancer risk. The data assembled by Tomasetti and Vogelstein, as augmented here, are inconsistent with the power-of-age relationship commonly observed for cancer incidence and the predictions of a multistage carcinogenesis model, if one makes the strong assumption of homogeneity of numbers of driver mutations across cancer sites. Analysis of the extra-risk score and various other measures (number of stem cell divisions per year, cumulative number of stem cell divisions over life) considered by Tomasetti and Vogelstein suggests that these are poorly predictive of currently available estimates of radiation- or smoking-associated cancer risk-for only one out of 37 measures or logarithmic transformations thereof is there a statistically significant correlation (p<0.05) with radiation- or smoking-associated risk. The data used by Tomasetti and Vogelstein are in conflict with predictions of a multistage model of carcinogenesis, under the assumption of homogeneity of numbers of driver mutations across most cancer sites. Their hypothesis that if the extra-risk score for a tissue type is high then one would expect that environmental factors would play a relatively more important role in that cancer's risk is in conflict with the lack of correlation between the extra-risk score and other stem-cell proliferation indices and radiation- or smoking-related cancer risk. JF - PloS one AU - Little, Mark P AU - Hendry, Jolyon H AU - Puskin, Jerome S AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Rockville, Maryland, United States of America. ; Christie Medical Physics and Engineering, Christie Hospital and University of Manchester, Manchester, United Kingdom. ; Radiation Protection Division, United States Environmental Protection Agency, Washington, DC, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 3 KW - Index Medicus KW - Risk KW - Humans KW - Linear Models KW - Incidence KW - Cell Proliferation KW - Models, Theoretical KW - Smoking KW - Stem Cells -- cytology KW - Radiation KW - Neoplasms -- epidemiology KW - Stem Cells -- metabolism KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1778709163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Lack+of+Correlation+between+Stem-Cell+Proliferation+and+Radiation-+or+Smoking-Associated+Cancer+Risk.&rft.au=Little%2C+Mark+P%3BHendry%2C+Jolyon+H%3BPuskin%2C+Jerome+S&rft.aulast=Little&rft.aufirst=Mark&rft.date=2016-01-01&rft.volume=11&rft.issue=3&rft.spage=e0150335&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0150335 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-05 N1 - Date created - 2016-04-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16226-31 [12446840] Nature. 2016 Jan 7;529(7584):43-7 [26675728] Proc Natl Acad Sci U S A. 1971 Apr;68(4):820-3 [5279523] J Natl Cancer Inst. 1980 Apr;64(4):977-89 [6929006] J Natl Cancer Inst. 1981 Jun;66(6):1191-308 [7017215] Environ Health Perspect. 1983 Apr;50:293-308 [6873020] Health Phys. 1988 Jun;54(6):635-43 [3378895] Risk Anal. 1989 Dec;9(4):551-63 [2608948] Environ Health Perspect. 1990 Jul;87:163-71 [2269222] Radiat Res. 1992 Nov;132(2):207-21 [1438703] Biometrics. 1995 Dec;51(4):1278-91 [8589222] Br J Cancer. 1954 Mar;8(1):1-12 [13172380] Br J Cancer. 2005 Feb 14;92(3):426-9 [15668706] Carcinogenesis. 2007 Feb;28(2):479-87 [16973671] Radiat Res. 2007 Jul;168(1):1-64 [17722996] Ann ICRP. 2007;37(2-4):1-332 [18082557] J Theor Biol. 2008 Sep 21;254(2):229-38 [18640693] Theor Popul Biol. 2010 Feb;77(1):42-8 [19896491] Radiat Res. 2012 Mar;177(3):229-43 [22171960] Radiat Environ Biophys. 2013 Mar;52(1):147-50 [23180111] Radiat Res. 2013 Jun;179(6):637-46 [23627781] Science. 2015 Jan 2;347(6217):78-81 [25554788] Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):118-23 [25535351] Science. 2015 Feb 13;347(6223):727 [25656658] Science. 2015 Feb 13;347(6223):728-9 [25678651] Science. 2015 Feb 13;347(6223):729 [25678652] Math Biosci. 2003 Jun;183(2):111-34 [12711407] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0150335 ER - TY - JOUR T1 - Carbon Monoxide Poisonings from Forklift Use During Produce Packing Operations. AN - 1777983449; 26788681 AB - In August 2013, the North Carolina Division of Public Health investigated a carbon monoxide (CO) exposure on a farm. Two employees were overcome by CO and lost consciousness while using a propane-powered forklift to load produce into a refrigerated trailer backed up to a warehouse. One employee died, and the second employee was admitted to the hospital for hyperbaric oxygen treatment. Eighteen people, ranging in age from 18 to 69 years, were potentially exposed to CO, including the two employees, a family member who discovered the employees, two bystanders who stopped to offer assistance, and 13 first responders. Thirteen people who assisted in the emergency response experienced symptoms such as headache and dizziness, and all 16 who assisted were evaluated in a local hospital emergency department and released after receiving 100% oxygen. Blood tests showed five people (the two employees, family member, and two bystanders) had elevated blood carboxyhemoglobin levels, but all first responders had levels within normal range. Firefighters measured a peak CO concentration of 2214 parts per million in the warehouse. The North Carolina Division of Occupational Safety and Health investigated and determined that the forklift, operated inside the trailer with no ventilation, was the source of the CO. Public health investigation activities included interviewing responders, obtaining ambient CO concentration measurements from the fire department, advising the local health director, reviewing medical records, and developing a line listing of exposed persons. To prevent CO poisoning, employers should consider replacing gas-powered equipment with electric equipment, which does not produce CO. JF - Journal of agromedicine AU - Hirsch, Anne E AU - Langley, Ricky L AU - McDaniel, Jesse S AD - a Division of Public Health, North Carolina Department of Health and Human Services , Raleigh , North Carolina , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 132 EP - 135 VL - 21 IS - 2 KW - Index Medicus KW - CO poisoning KW - Carbon monoxide poisoning KW - forklift KW - Young Adult KW - Farms KW - Humans KW - Agricultural Workers' Diseases -- etiology KW - North Carolina KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Occupational Exposure KW - Carbon Monoxide Poisoning -- etiology KW - Carbon Monoxide Poisoning -- therapy KW - Motor Vehicles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777983449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Carbon+Monoxide+Poisonings+from+Forklift+Use+During+Produce+Packing+Operations.&rft.au=Hirsch%2C+Anne+E%3BLangley%2C+Ricky+L%3BMcDaniel%2C+Jesse+S&rft.aulast=Hirsch&rft.aufirst=Anne&rft.date=2016-01-01&rft.volume=21&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1545-0813&rft_id=info:doi/10.1080%2F1059924X.2016.1142915 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2017-01-10 N1 - Date created - 2016-03-31 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/1059924X.2016.1142915 ER - TY - JOUR T1 - Supporting read-across using biological data. AN - 1777982756; 26863516 AB - Read-across, i.e. filling toxicological data gaps by relating to similar chemicals, for which test data are available, is usually done based on chemical similarity. Besides structure and physico-chemical properties, however, biological similarity based on biological data adds extra strength to this process. In the context of developing Good Read-Across Practice guidance, a number of case studies were evaluated to demonstrate the use of biological data to enrich read-across. In the simplest case, chemically similar substances also show similar test results in relevant in vitro assays. This is a well-established method for the read-across of e.g. genotoxicity assays. Larger datasets of biological and toxicological properties of hundreds and thousands of substances become increasingly available enabling big data approaches in read-across studies. Several case studies using various big data sources are described in this paper. An example is given for the US EPA's ToxCast dataset allowing read-across for high quality uterotrophic assays for estrogenic endocrine disruption. Similarly, an example for REACH registration data enhancing read-across for acute toxicity studies is given. A different approach is taken using omics data to establish biological similarity: Examples are given for stem cell models in vitro and short-term repeated dose studies in rats in vivo to support read-across and category formation. These preliminary biological data-driven read-across studies highlight the road to the new generation of read-across approaches that can be applied in chemical safety assessment. JF - ALTEX AU - Zhu, Hao AU - Bouhifd, Mounir AU - Donley, Elizabeth AU - Egnash, Laura AU - Kleinstreuer, Nicole AU - Kroese, E Dinant AU - Liu, Zhichao AU - Luechtefeld, Thomas AU - Palmer, Jessica AU - Pamies, David AU - Shen, Jie AU - Strauss, Volker AU - Wu, Shengde AU - Hartung, Thomas AD - Department of Chemistry and Center for Computational and Integrative Biology, Rutgers University, Camden, NJ, USA. ; Johns Hopkins Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA. ; Stemina Biomarker Discovery Inc., Madison, WI, USA. ; National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA. ; Risk Analysis for Products in Development, TNO Zeist, The Netherlands. ; US FDA, NCTR, Little Rock, Arkansas, USA. ; Research Institute for Fragrance Materials, Inc. Woodcliff Lake, New Jersey, USA. ; BASF Aktiengesellschaft, Experimental Toxicology and Ecology, Ludwigshafen, Germany. ; Procter & Gamble, Cincinnati, OH, USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 167 EP - 182 VL - 33 IS - 2 SN - 1868-596X, 1868-596X KW - Hazardous Substances KW - 0 KW - Index Medicus KW - read-across KW - biological similarity KW - safety assessment KW - big data KW - Rats KW - Molecular Structure KW - High-Throughput Screening Assays KW - Animals KW - Animal Testing Alternatives KW - Data Mining KW - Structure-Activity Relationship KW - Biological Assay -- methods KW - Hazardous Substances -- chemistry KW - Databases, Factual KW - Hazardous Substances -- toxicity KW - Chemical Safety -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777982756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ALTEX&rft.atitle=Supporting+read-across+using+biological+data.&rft.au=Zhu%2C+Hao%3BBouhifd%2C+Mounir%3BDonley%2C+Elizabeth%3BEgnash%2C+Laura%3BKleinstreuer%2C+Nicole%3BKroese%2C+E+Dinant%3BLiu%2C+Zhichao%3BLuechtefeld%2C+Thomas%3BPalmer%2C+Jessica%3BPamies%2C+David%3BShen%2C+Jie%3BStrauss%2C+Volker%3BWu%2C+Shengde%3BHartung%2C+Thomas&rft.aulast=Zhu&rft.aufirst=Hao&rft.date=2016-01-01&rft.volume=33&rft.issue=2&rft.spage=167&rft.isbn=&rft.btitle=&rft.title=ALTEX&rft.issn=1868596X&rft_id=info:doi/10.14573%2Faltex.1601252 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-21 N1 - Date created - 2016-03-31 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: ALTEX. 2012;29(4):411-25 [23138511] Toxicol Lett. 2012 Nov 30;215(2):143-9 [23103988] Chem Res Toxicol. 2012 Dec 17;25(12):2763-9 [23148656] ALTEX. 2013;30(1):3-18 [23338803] ALTEX. 2013;30(2):209-25 [23665807] Reprod Toxicol. 2013 Jul;38:53-64 [23511061] Chem Res Toxicol. 2013 Jun 17;26(6):878-95 [23611293] Environ Health Perspect. 2013 Jul;121(7):A228 [23816934] Chem Res Toxicol. 2013 Aug 19;26(8):1199-208 [23848138] Toxicology. 2013 Oct 4;312:158-65 [23978457] Birth Defects Res B Dev Reprod Toxicol. 2013 Aug;98(4):343-63 [24123775] J Appl Toxicol. 2013 Dec;33(12):1365-83 [23722930] Toxicol Sci. 2013 Nov;136(1):97-106 [23945500] Chem Res Toxicol. 2013 Dec 16;26(12):1840-61 [24206190] ALTEX. 2014;31(1):53-61 [24127042] Toxicol Lett. 2014 Mar 3;225(2):240-51 [24370789] Pharm Res. 2014 Apr;31(4):1002-14 [24306326] Toxicol Lett. 2014 May 16;227(1):20-8 [24657160] Nat Biotechnol. 2014 Jun;32(6):583-91 [24837663] PLoS One. 2014;9(6):e99863 [24950175] ALTEX. 2014;31(3):341-56 [25061899] Chem Res Toxicol. 2014 Oct 20;27(10):1643-51 [25195622] ALTEX. 2014;31(4):387-96 [25368965] ALTEX. 2015;32(1):3-8 [25592482] Reprod Toxicol. 2015 Aug 1;55:30-49 [25263227] Reprod Toxicol. 2015 Aug 1;55:11-9 [25461900] Reprod Toxicol. 2015 Aug 1;55:73-80 [25462785] ALTEX. 2015;32(3):171-81 [26168280] Pharm Res. 2015 Sep;32(9):3055-65 [25862462] ALTEX. 2015;32(4):319-26 [26536290] ALTEX. 2016;33(2):95-109 [26863090] ALTEX. 2016;33(2):111-22 [26863198] ALTEX. 2016;33(2):123-34 [26863293] ALTEX. 2016;33(2):135-48 [26863411] ALTEX. 2016;33(2):149-66 [26863606] Environ Health Perspect. 2016 May;124(5):634-41 [26383846] Environ Health Perspect. 2016 May;124(5):556-62 [26431337] Toxicol Lett. 2010 Feb 15;192(3):271-7 [19913079] Cells Tissues Organs. 1999;165(3-4):203-11 [10592392] Toxicol Ind Health. 2000 Jan;16(1):4-6 [10798381] Toxicol In Vitro. 2002 Jun;16(3):299-317 [12020604] Environ Health Perspect. 2003 May;111(6):793-5 [12760826] Pharmacogenomics J. 2004;4(1):5-8 [14735110] SAR QSAR Environ Res. 2004 Aug;15(4):251-63 [15370416] Crit Rev Toxicol. 1998 Jan;28(1):1-33 [9493760] Science. 2004 Nov 12;306(5699):1138-9 [15542455] Toxicol Sci. 2005 Jan;83(1):136-48 [15483189] Altern Lab Anim. 2004 Nov;32(5):467-72 [15656771] J Biotechnol. 2005 Sep 29;119(3):219-44 [16005536] Toxicology. 2006 Mar 15;220(2-3):232-9 [16555380] Environ Sci Pollut Res Int. 2011 Mar;18(3):503-15 [20890769] Toxicol Sci. 2011 Mar;120(1):194-205 [21097997] Toxicol In Vitro. 2011 Apr;25(3):745-53 [21238576] Toxicol Appl Pharmacol. 2011 Apr 15;252(2):73-84 [20955723] Arch Toxicol. 2011 May;85(5):367-485 [21533817] Reprod Toxicol. 2011 May;31(4):558–61 [21766522] Toxicol Lett. 2011 Nov 30;207(2):173-81 [21907771] Environ Health Perspect. 2011 Nov;119(11):1596-603 [21788198] Toxicol Sci. 2006 Aug;92(2):587-95 [16675512] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8 [16864780] J Exp Zool A Comp Exp Biol. 2006 Sep 1;305(9):689-92 [16902965] Science. 2006 Sep 29;313(5795):1929-35 [17008526] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] ALTEX. 2007;24(2):67-80 [17844647] Nucleic Acids Res. 2008 Jan;36(Database issue):D892-900 [17962311] J Chem Inf Model. 2008 Apr;48(4):766-84 [18311912] Mol Nutr Food Res. 2010 Feb;54(2):218-27 [20041446] Environ Health Perspect. 2010 Apr;118(4):485-92 [20368123] ALTEX. 2010;27(1):3-14 [20390236] Reprod Toxicol. 2010 Aug;30(1):200-18 [20493943] Toxicol Lett. 2010 Oct 5;198(2):159-70 [20600714] Environ Toxicol Chem. 2010 Mar;29(3):730-41 [20821501] Mutat Res. 2010 Dec;705(3):172-83 [20382258] Environ Health Perspect. 2010 Dec;118(12):1714-20 [20826373] Birth Defects Res B Dev Reprod Toxicol. 2010 Dec;89(6):526-30 [21086491] ALTEX. 2011;28(1):17-44 [21311848] Toxicol Appl Pharmacol. 2008 Nov 15;233(1):7-13 [18671997] ChemMedChem. 2009 Feb;4(2):210-8 [19072820] Nucleic Acids Res. 2009 Jul;37(Web Server issue):W623-33 [19498078] Toxicol Lett. 2009 Dec 1;191(1):88-95 [19683565] ALTEX. 2009;26(3):155-66 [19907903] Curr Top Med Chem. 2009;9(13):1181-93 [19807664] Chem Res Toxicol. 2009 Dec;22(12):1913-21 [19845371] Nucleic Acids Res. 2010 Jan;38(Database issue):D255-66 [19933261] Nucleic Acids Res. 2012 Jan;40(Database issue):D1100-7 [21948594] Birth Defects Res C Embryo Today. 2011 Dec;93(4):312-23 [22271680] Arch Toxicol. 2012 Mar;86(3):405-12 [22038139] Int J Mol Sci. 2012;13(2):1805-31 [22408426] Mutat Res. 2012 Aug 15;746(2):144-50 [22305969] Mutat Res. 2012 Aug 15;746(2):135-43 [22305970] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.14573/altex.1601252 ER - TY - JOUR T1 - Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease. AN - 1777079090; 27019000 AB - Niemann-Pick type C (NPC) disease is a neurodegenerative lysosomal storage disease caused by mutations in either the NPC1 or NPC2 gene. NPC is characterised by storage of multiple lipids in the late endosomal/lysosomal compartment, resulting in cellular and organ system dysfunction. The underlying molecular mechanisms that lead to the range of clinical presentations in NPC are not fully understood. While evaluating potential small molecule therapies in Npc1-/- mice, we observed a consistent pattern of toxicity associated with drugs metabolised by the cytochrome P450 system, suggesting a potential drug metabolism defect in NPC1 disease. Investigation of the P450 system in the context of NPC1 dysfunction revealed significant changes in the gene expression of many P450 associated genes across the full lifespan of Npc1-/- mice, decreased activity of cytochrome P450 reductase, and a global decrease of multiple cytochrome P450 catalysed dealkylation reactions. In vivo drug metabolism studies using a prototypic P450 metabolised drug, midazolam, confirmed dysfunction in drug clearance in the Npc1-/- mouse. Expression of the Phase II enzyme uridinediphosphate-glucuronosyltransferase (UGT) was also significantly reduced in Npc1-/- mice. Interestingly, reduced activity within the P450 system was also observed in heterozygous Npc1+/- mice. The reduced activity of P450 enzymes may be the result of bile acid deficiency/imbalance in Npc1-/- mice, as bile acid treatment significantly rescued P450 enzyme activity in Npc1-/- mice and has the potential to be an adjunctive therapy for NPC disease patients. The dysfunction in the cytochrome P450 system were recapitulated in the NPC1 feline model. Additionally, we present the first evidence that there are alterations in the P450 system in NPC1 patients. JF - PloS one AU - Nicoli, Elena-Raluca AU - Al Eisa, Nada AU - Cluzeau, Celine V M AU - Wassif, Christopher A AU - Gray, James AU - Burkert, Kathryn R AU - Smith, David A AU - Morris, Lauren AU - Cologna, Stephanie M AU - Peer, Cody J AU - Sissung, Tristan M AU - Uscatu, Constantin-Daniel AU - Figg, William D AU - Pavan, William J AU - Vite, Charles H AU - Porter, Forbes D AU - Platt, Frances M AD - Department of Pharmacology, University of Oxford, Oxford, United Kingdom. ; Section of Molecular Dysmorphology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America. ; Clinical Pharmacology Program, Medical Oncology Branch, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland, United States of America. ; Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America. ; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 3 KW - Npc1 protein, mouse KW - 0 KW - Proteins KW - beta-Cyclodextrins KW - Ursodeoxycholic Acid KW - 724L30Y2QR KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - 2-hydroxypropyl-beta-cyclodextrin KW - 94035-02-6 KW - Midazolam KW - R60L0SM5BC KW - Index Medicus KW - Models, Animal KW - Mass Spectrometry KW - Animals KW - Liver -- enzymology KW - Midazolam -- blood KW - Humans KW - Microsomes, Liver -- metabolism KW - Mice, Inbred BALB C KW - Chromatography, High Pressure Liquid KW - Mice, Knockout KW - Behavior, Animal -- drug effects KW - Liver -- drug effects KW - Dietary Supplements KW - Midazolam -- metabolism KW - Real-Time Polymerase Chain Reaction KW - Ursodeoxycholic Acid -- metabolism KW - Mice KW - beta-Cyclodextrins -- therapeutic use KW - Midazolam -- pharmacology KW - Proteins -- genetics KW - Proteins -- metabolism KW - beta-Cyclodextrins -- metabolism KW - Ursodeoxycholic Acid -- pharmacology KW - Cats KW - Microsomes, Liver -- enzymology KW - Niemann-Pick Disease, Type C -- pathology KW - Cytochrome P-450 Enzyme System -- genetics KW - Niemann-Pick Disease, Type C -- drug therapy KW - Cytochrome P-450 Enzyme System -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1777079090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Defective+Cytochrome+P450-Catalysed+Drug+Metabolism+in+Niemann-Pick+Type+C+Disease.&rft.au=Nicoli%2C+Elena-Raluca%3BAl+Eisa%2C+Nada%3BCluzeau%2C+Celine+V+M%3BWassif%2C+Christopher+A%3BGray%2C+James%3BBurkert%2C+Kathryn+R%3BSmith%2C+David+A%3BMorris%2C+Lauren%3BCologna%2C+Stephanie+M%3BPeer%2C+Cody+J%3BSissung%2C+Tristan+M%3BUscatu%2C+Constantin-Daniel%3BFigg%2C+William+D%3BPavan%2C+William+J%3BVite%2C+Charles+H%3BPorter%2C+Forbes+D%3BPlatt%2C+Frances+M&rft.aulast=Nicoli&rft.aufirst=Elena-Raluca&rft.date=2016-01-01&rft.volume=11&rft.issue=3&rft.spage=e0152007&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0152007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-05 N1 - Date created - 2016-03-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Genet Metab. 2012 Jul;106(3):330-44 [22572546] Br J Pharmacol. 2012 Aug;166(7):2176-87 [22394353] Hum Mol Genet. 2012 Aug 15;21(16):3632-46 [22619379] Orphanet J Rare Dis. 2013;8:12 [23324478] Biochimie. 2013 Mar;95(3):455-60 [22732193] Pharmacol Ther. 2013 Apr;138(1):103-41 [23333322] Steroids. 2013 Oct;78(10):967-72 [23751200] Brain. 2013 Oct;136(Pt 10):3038-50 [24000005] Curr Top Med Chem. 2014;14(3):330-9 [24283970] J Biol Chem. 2014 Jun 6;289(23):16278-89 [24790103] Ann Clin Biochem. 2015 Sep;52(Pt 5):576-87 [25575700] Neurology. 2015 Sep 8;85(10):846-52 [26253449] Lancet. 2015 Oct 17;386(10003):1565-75 [26364546] Genet Med. 2016 Jan;18(1):41-8 [25764212] Lancet. 2000 Feb 19;355(9204):657-8 [10697011] Biochem Pharmacol. 2000 Jun 15;59(12):1501-11 [10799646] J Neuropathol Exp Neurol. 2000 Dec;59(12):1106-17 [11138930] J Med Chem. 2001 Mar 15;44(6):886-97 [11300870] Curr Biol. 2001 Aug 21;11(16):1283-7 [11525744] J Lipid Res. 2001 Oct;42(10):1571-7 [11590212] J Neurosci. 2001 Nov 1;21(21):8370-7 [11606625] Science. 2001 Nov 30;294(5548):1866-70 [11729302] Cancer Epidemiol Biomarkers Prev. 2002 Jun;11(6):535-40 [12050094] J Biol Chem. 2002 Aug 16;277(33):29561-7 [12045201] Hepatology. 2002 Oct;36(4 Pt 1):819-28 [12297829] Curr Opin Investig Drugs. 2003 Apr;4(4):472-9 [12808890] Clin Genet. 2003 Oct;64(4):269-81 [12974729] N Engl J Med. 2003 Sep 18;349(12):1157-67 [13679531] Ann Neurol. 2004 Mar;55(3):430-4 [14991823] Pharmacogenetics. 2004 Jan;14(1):1-18 [15128046] Neurobiol Dis. 2004 Aug;16(3):654-8 [15262277] Ann Hepatol. 2004 Jul-Sep;3(3):108-12 [15505596] Annu Rev Nutr. 1981;1:207-34 [6821186] Br J Clin Pharmacol. 1983;16 Suppl 1:43S-49S [6138080] Fundam Appl Toxicol. 1984 Jun;4(3 Pt 2):S341-56 [6745553] Mol Pharmacol. 1988 Nov;34(5):628-37 [3264050] Mol Pharmacol. 1989 Jul;36(1):89-96 [2787473] Drug Metab Dispos. 1992 May-Jun;20(3):446-50 [1355722] Cancer Lett. 1992 Sep 14;66(1):21-8 [1451092] J Pediatr. 1993 Aug;123(2):242-7 [7688422] Biochem Pharmacol. 1993 Sep 1;46(5):933-43 [8373445] Biochem Pharmacol. 1994 Aug 30;48(5):923-36 [8093105] Nature. 1996 Oct 24;383(6602):728-31 [8878485] Science. 1997 Jul 11;277(5323):232-5 [9211850] J Inherit Metab Dis. 1998 Apr;21(2):149-54 [9584266] Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):266-71 [9874807] Int J Obes Relat Metab Disord. 1999 Jan;23(1):48-53 [10094576] Neurochem Res. 1999 Apr;24(4):481-9 [10227680] Arch Biochem Biophys. 2005 Jan 15;433(2):397-412 [15581596] Gastroenterology. 2005 Feb;128(2):297-303 [15685541] J Biol Chem. 2005 Mar 25;280(12):11731-9 [15644330] Drug Metab Dispos. 2005 Jul;33(7):892-5 [15845749] Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13807-12 [16940355] Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):875-94 [17125407] Toxicology. 2007 Jun 3;235(1-2):83-91 [17433521] Lancet Neurol. 2007 Sep;6(9):765-72 [17689147] J Neurosci. 2007 Dec 26;27(52):14470-80 [18160655] Drug Metab Pharmacokinet. 2008;23(1):14-21 [18305371] Mol Genet Metab. 2008 Jun;94(2):204-11 [18387328] FASEB J. 2008 Oct;22(10):3617-27 [18591368] Nat Med. 2008 Nov;14(11):1247-55 [18953351] Mol Pharmacol. 2009 Aug;76(2):215-28 [19483103] Neurobiol Dis. 2009 Nov;36(2):242-51 [19632328] Mov Disord. 2009 Oct 15;24(13):1984-90 [19672994] J Child Neurol. 2010 Mar;25(3):300-5 [19822772] Mol Genet Metab. 2010 Apr;99(4):351-7 [20045366] Orphanet J Rare Dis. 2010;5:16 [20525256] J Lipid Res. 2010 Aug;51(8):2372-83 [20418540] Drug Metab Dispos. 2010 Nov;38(11):2007-13 [20713656] Sci Transl Med. 2010 Nov 3;2(56):56ra81 [21048217] Curr Drug Metab. 2011 Feb;12(2):173-85 [21395540] Pharmacol Biochem Behav. 2012 Mar;101(1):125-31 [22202649] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0152007 ER - TY - JOUR T1 - A study update of mortality in workers at a phosphate fertilizer production facility AN - 1776668361; PQ0002763846 AB - Objective To evaluate the mortality experience among 3,199 workers employed 1951-1976 at a phosphate fertilizer production plant in central Florida with follow-up through 2011. Methods Cause-specific standardized mortality ratios (SMRs) for the full cohort were calculated with the U.S. population as referent. Lung cancer and leukemia risks were further analyzed using conditional logistic regression. Results The mortality due to all-causes (SMR=1.07, 95% confidence interval [CI] 1.02-1.13, observed deaths [n]=1,473), all-cancers (SMR=1.16, 95%CI 1.06-1.28, n=431), and a priori outcomes of interests including lung cancer (SMR=1.32, 95%CI=1.13-1.53, n=168) and leukemia (SMR=1.74, 95%CI=1.11-2.62, n=23) were statistically significantly elevated. Regression modeling on employment duration or estimated radiation scores did not show exposure-response relation with lung cancer or leukemia mortality. Conclusion SMR results showed increased lung cancer and leukemia mortality in a full cohort of the phosphate fertilizer production facility. There was, however, no exposure-response relation observed among cases and matched controls. Am. J. Ind. Med. 59:12-22, 2016. JF - American Journal of Industrial Medicine AU - Yiin, James H AU - Daniels, Robert D AU - Kubale, Travis L AU - Dunn, Kevin L AU - Stayner, Leslie T AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 12 EP - 22 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 59 IS - 1 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - ASW, USA, Florida KW - Mortality KW - Employment KW - Agrochemicals KW - Cancer KW - Leukemia KW - Health risks KW - Fertilizers KW - Phosphates KW - Radiation KW - Dose-response effects KW - Standards KW - Lung cancer KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776668361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=A+study+update+of+mortality+in+workers+at+a+phosphate+fertilizer+production+facility&rft.au=Yiin%2C+James+H%3BDaniels%2C+Robert+D%3BKubale%2C+Travis+L%3BDunn%2C+Kevin+L%3BStayner%2C+Leslie+T&rft.aulast=Yiin&rft.aufirst=James&rft.date=2016-01-01&rft.volume=59&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22542 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Health risks; Leukemia; Mortality; Fertilizers; Phosphates; Radiation; Dose-response effects; Standards; Employment; Agrochemicals; Cancer; Lung cancer; ASW, USA, Florida DO - http://dx.doi.org/10.1002/ajim.22542 ER - TY - JOUR T1 - Improved Stability of a Model IgG3 by DoE-Based Evaluation of Buffer Formulations AN - 1776651015; PQ0002751343 AB - Formulating appropriate storage conditions for biopharmaceutical proteins is essential for ensuring their stability and thereby their purity, potency, and safety over their shelf-life. Using a model murine IgG3 produced in a bioreactor system, multiple formulation compositions were systematically explored in a DoE design to optimize the stability of a challenging antibody formulation worst case. The stability of the antibody in each buffer formulation was assessed by UV/VIS absorbance at 280 nm and 410 nm and size exclusion high performance liquid chromatography (SEC) to determine overall solubility, opalescence, and aggregate formation, respectively. Upon preliminary testing, acetate was eliminated as a potential storage buffer due to significant visible precipitate formation. An additional 2 super(4) full factorial DoE was performed that combined the stabilizing effect of arginine with the buffering capacity of histidine. From this final DoE, an optimized formulation of 200 mM arginine, 50 mM histidine, and 100 mM NaCl at a pH of 6.5 was identified to substantially improve stability under long-term storage conditions and after multiple freeze/thaw cycles. Thus, our data highlights the power of DoE based formulation screening approaches even for challenging monoclonal antibody molecules. JF - BioMed Research International AU - Chavez, Brittany K AU - Agarabi, Cyrus D AU - Read, Erik K AU - Boyne, Michael T, II AU - Khan, Mansoor A AU - Brorson, Kurt A AD - Division II, Office of Biotechnology Products, OPQ, CDER, FDA, Silver Spring, MD 20903, USA, kurt.brorson@fda.hhs.gov Y1 - 2016/01// PY - 2016 DA - January 2016 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2016 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - High-performance liquid chromatography KW - Data processing KW - Solubility KW - Monoclonal antibodies KW - Arginine KW - Shelf life KW - Acetic acid KW - Models KW - Bioreactors KW - Storage conditions KW - Histidine KW - Immunoglobulin G KW - Pharmaceuticals KW - Absorbance KW - pH effects KW - Sodium chloride KW - W 30950:Waste Treatment & Pollution Clean-up UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776651015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Improved+Stability+of+a+Model+IgG3+by+DoE-Based+Evaluation+of+Buffer+Formulations&rft.au=Chavez%2C+Brittany+K%3BAgarabi%2C+Cyrus+D%3BRead%2C+Erik+K%3BBoyne%2C+Michael+T%2C+II%3BKhan%2C+Mansoor+A%3BBrorson%2C+Kurt+A&rft.aulast=Chavez&rft.aufirst=Brittany&rft.date=2016-01-01&rft.volume=2016&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2016%2F2074149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Solubility; Data processing; Arginine; Monoclonal antibodies; Shelf life; Acetic acid; Models; Histidine; Storage conditions; Bioreactors; Immunoglobulin G; Pharmaceuticals; Absorbance; pH effects; Sodium chloride DO - http://dx.doi.org/10.1155/2016/2074149 ER - TY - JOUR T1 - A Phase II trial of tandutinib (MLN 518) in combination with bevacizumab for patients with recurrent glioblastoma. AN - 1775633102; 26860632 AB - A Phase II trial of bevacizumab plus tandutinib. We enrolled 41 recurrent, bevacizumab-naive glioblastoma patients for a trial of bevacizumab plus tandutinib. Median age was 55 and 71% were male. Treatment consisted of tandutinib 500 mg two-times a day (b.i.d.) and bevacizumab 10 mg/kg every 2 weeks starting day 15. Of 37 (90%) evaluable, nine (24%) had partial response. Median overall and progression-free survival was 11 and 4.1 months; progression-free survival at 6 months was 23%. All patients suffered treatment-related toxicities; common grade ≥3 toxicities were hypertension (17.1%), muscle weakness (17.1%), lymphopenia (14.6%) and hypophosphatemia (9.8%). Four of six with grade ≥3 tandutinib-related myasthenic-like muscle weakness had electromyography-proven neuromuscular junction pathology. Tandutinib with bevacizumab was as effective but more toxic than bevacizumab monotherapy. JF - CNS oncology AU - Odia, Yazmin AU - Sul, Joohee AU - Shih, Joanna H AU - Kreisl, Teri N AU - Butman, John A AU - Iwamoto, Fabio M AU - Fine, Howard A AD - Neuro-Oncology Division, Neurological Institute of New York, Columbia University College of Physicians & Surgeons, 710 West 168th Street, 9th Floor, New York, NY 10032, USA. ; US FDA, 10903 New Hampshire Ave, Bldg WO22 Rm 2331, Silver Spring, MD 20993, USA. ; Biometric Research Branch, Division of Cancer Treatment & Diagnosis, NCI, 9609 Medical Center Drive, Room 5W124, Rockville, MD 20850, USA. ; Department of Radiology, National Institutes of Health Clinical Center, Building 10, Clinical Center 10 Center Drive, MSC 1074, Bethesda, MD 20892, USA. ; Division of Neuro-Oncology, Director of the Brain Tumor Center, New York-Presbyterian Hospital/Weill Cornell Medical Center, 1305 York Avenue, 9th Floor, New York, NY 10021, USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 59 EP - 67 VL - 5 IS - 2 KW - Piperazines KW - 0 KW - Quinazolines KW - Bevacizumab KW - 2S9ZZM9Q9V KW - tandutinib KW - E1IO3ICJ9A KW - Index Medicus KW - bevacizumab KW - glioblastoma KW - Kaplan-Meier Estimate KW - Disease-Free Survival KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Bevacizumab -- therapeutic use KW - Bevacizumab -- adverse effects KW - Brain Neoplasms -- drug therapy KW - Neoplasm Recurrence, Local -- drug therapy KW - Piperazines -- therapeutic use KW - Quinazolines -- therapeutic use KW - Glioblastoma -- drug therapy KW - Quinazolines -- adverse effects KW - Piperazines -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1775633102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CNS+oncology&rft.atitle=A+Phase+II+trial+of+tandutinib+%28MLN+518%29+in+combination+with+bevacizumab+for+patients+with+recurrent+glioblastoma.&rft.au=Odia%2C+Yazmin%3BSul%2C+Joohee%3BShih%2C+Joanna+H%3BKreisl%2C+Teri+N%3BButman%2C+John+A%3BIwamoto%2C+Fabio+M%3BFine%2C+Howard+A&rft.aulast=Odia&rft.aufirst=Yazmin&rft.date=2016-01-01&rft.volume=5&rft.issue=2&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=CNS+oncology&rft.issn=2045-0915&rft_id=info:doi/10.2217%2Fcns-2015-0010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-26 N1 - Date created - 2016-03-23 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00667394; ClinicalTrials.gov N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/cns-2015-0010 ER - TY - JOUR T1 - Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers. AN - 1773430405; 26967509 AB - Alcohol is a known carcinogen that may be associated with colorectal cancer. However, most epidemiologic studies assess alcoholic beverage consumption using self-reported data, leading to potential exposure misclassification. Biomarkers of alcohol consumption may provide an alternative, complementary approach that reduces misclassification and incorporates individual differences in alcohol metabolism. Therefore, we evaluated the relationship between previously identified alcohol consumption-related metabolites and colorectal cancer and adenoma using serum metabolomics data from two studies. Data on colorectal cancer were obtained from a nested case-control study of 502 US adults (252 cases, 250 controls) within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Data on colorectal adenoma were obtained from a case-control study of 197 US adults (120 cases, 77 controls) from the Navy Colon Adenoma Study. Unconditional multivariable logistic regression models were fit to calculate odds ratios (OR) and 95% confidence intervals (CI) for eight alcohol consumption-related metabolites identified in a previous analysis: ethyl glucuronide; 4-androstene-3beta,17beta-diol disulfate 1; 5-alpha-androstan-3beta,17beta-diol disulfate; 16-hydroxypalmitate; bilirubin (E,Z or Z,E); cyclo (-leu-pro); dihomo-linoleate (20:2n6); and palmitoleate (16:1n7). We found no clear association between these alcohol consumption-related metabolites and either endpoint. However, we did observe an inverse association between cyclo (-leu-pro) and colorectal adenoma that was only observed in the highest metabolite quantile (OR 4th vs. 1st Quantile = 0.30, 95% CI: 0.12-0.78; P-trend = 0.047), but no association for colorectal cancer. In conclusion, there were no adverse associations between alcohol consumption-related metabolites and colorectal cancer or adenoma. JF - PloS one AU - Troche, Jose Ramon AU - Mayne, Susan T AU - Freedman, Neal D AU - Shebl, Fatma M AU - Guertin, Kristin A AU - Cross, Amanda J AU - Abnet, Christian C AD - Yale School of Public Health, New Haven, Connecticut, United States of America. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America. ; Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, United States of America. ; Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, St. Mary's Campus, Norfolk Place, London, United Kingdom. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 3 KW - Biomarkers KW - 0 KW - Dipeptides KW - Fatty Acids, Monounsaturated KW - Glucuronates KW - Palmitic Acids KW - Peptides, Cyclic KW - cyclo(leucyl-prolyl) KW - ethyl glucuronide KW - 17685-04-0 KW - palmitoleic acid KW - 209B6YPZ4I KW - Androstane-3,17-diol KW - 25126-76-5 KW - Ethanol KW - 3K9958V90M KW - 16-hydroxypalmitic acid KW - 7IPP3U0F3I KW - androstane-3,7-diol disulfate KW - 89453-66-7 KW - Linoleic Acid KW - 9KJL21T0QJ KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - Fatty Acids, Monounsaturated -- blood KW - Odds Ratio KW - Humans KW - Peptides, Cyclic -- blood KW - Palmitic Acids -- blood KW - Aged KW - Androstane-3,17-diol -- analogs & derivatives KW - Glucuronates -- blood KW - Linoleic Acid -- blood KW - Case-Control Studies KW - Middle Aged KW - Androstane-3,17-diol -- blood KW - Bilirubin -- blood KW - Biomarkers -- blood KW - Male KW - Female KW - Dipeptides -- blood KW - Alcohol Drinking -- adverse effects KW - Colorectal Neoplasms -- blood KW - Alcoholic Beverages -- adverse effects KW - Ethanol -- metabolism KW - Adenoma -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773430405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Alcohol+Consumption-Related+Metabolites+in+Relation+to+Colorectal+Cancer+and+Adenoma%3A+Two+Case-Control+Studies+Using+Serum+Biomarkers.&rft.au=Troche%2C+Jose+Ramon%3BMayne%2C+Susan+T%3BFreedman%2C+Neal+D%3BShebl%2C+Fatma+M%3BGuertin%2C+Kristin+A%3BCross%2C+Amanda+J%3BAbnet%2C+Christian+C&rft.aulast=Troche&rft.aufirst=Jose&rft.date=2016-01-01&rft.volume=11&rft.issue=3&rft.spage=e0150962&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0150962 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-03-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Epidemiol. 1993 Jun;22(3):398-402 [8359954] Nutr Cancer. 1992;18(2):97-111 [1437657] Addiction. 1994 Apr;89(4):407-12 [8025493] Epidemiol Rev. 1994;16(2):273-97 [7713180] J Natl Cancer Inst. 1998 Jan 7;90(1):57-62 [9428784] Cancer Res. 1999 Sep 1;59(17):4320-4 [10485479] Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):892-6 [16702366] Int J Cancer. 2007 Feb 1;120(3):664-71 [17096321] Cancer Control. 2007 Jan;14(1):78-85 [17242674] Alcohol Res Health. 2007;30(1):5-13 [17718394] Br J Cancer. 2009 Mar 10;100(5):803-6 [19223903] Cancer Epidemiol. 2009 Nov;33(5):347-54 [19932648] Anal Chem. 2009 Aug 15;81(16):6656-67 [19624122] Cancer Epidemiol Biomarkers Prev. 2010 Aug;19(8):1893-907 [20647400] Ann Oncol. 2011 Sep;22(9):1958-72 [21307158] Nature. 2011 Sep 1;477(7362):54-60 [21886157] Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):631-40 [23396963] Cancer Causes Control. 2013 Jul;24(7):1375-83 [23619609] Carcinogenesis. 2014 Jul;35(7):1516-22 [24648381] Br J Cancer. 2015 Feb 3;112(3):580-93 [25422909] Am J Clin Nutr. 2014 Jul;100(1):208-17 [24740205] Dig Dis Sci. 2000 Mar;45(3):487-93 [10749322] Cancer Causes Control. 2000 May;11(5):403-11 [10877333] Control Clin Trials. 2000 Dec;21(6 Suppl):251S-272S [11189683] Control Clin Trials. 2000 Dec;21(6 Suppl):273S-309S [11189684] J Natl Cancer Inst. 2001 May 2;93(9):710-5 [11333294] Gut. 2002 Jan;50(1):38-42 [11772965] Ann Intern Med. 2004 Apr 20;140(8):603-13 [15096331] Br J Addict. 1982 Dec;77(4):357-82 [6762224] Am J Epidemiol. 1988 Nov;128(5):1007-15 [3189277] Gut. 1991 Jan;32(1):70-2 [1991640] Cancer Causes Control. 1990 Jul;1(1):59-68 [2151680] Ann Epidemiol. 1993 May;3(3):239-44 [8275195] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0150962 ER - TY - JOUR T1 - Inhibition of Nickel Nanoparticles-Induced Toxicity by Epigallocatechin-3-Gallate in JB6 Cells May Be through Down-Regulation of the MAPK Signaling Pathways. AN - 1771447242; 26943640 AB - With the rapid development in nanotechnology, nickel nanoparticles (Ni NPs) have emerged in the application of nanomedicine in recent years. However, the potential adverse health effects of Ni NPs are unclear. In this study, we examined the inhibition effects of epigallocatechin-3-gallate (EGCG) on the toxicity induced by Ni NPs in mouse epidermal cell line (JB6 cell). MTT assay showed that Ni NPs induced cytotoxicity in a dose-dependent manner while EGCG exerted a certain inhibition on the toxicity. Additionally, EGCG could reduce the apoptotic cell number and the level of reactive oxygen species (ROS) in JB6 cells induced by Ni NPs. Furthermore, we observed that EGCG could down-regulate Ni NPs-induced activator protein-1 (AP-1) and nuclear factor-κB (NF-κB) activation in JB6 cells, which has been shown to play pivotal roles in tumor initiation, promotion and progression. Western blot indicated that EGCG could alleviate the toxicity of Ni NPs through regulating protein changes in MAPK signaling pathways. In summary, our results suggest that careful evaluation on the potential health effects of Ni NPs is necessary before being widely used in the field of nanomedicine. Inhibition of EGCG on Ni NPs-induced cytotoxicity in JB6 cells may be through the MAPK signaling pathways suggesting that EGCG might be useful in preventing the toxicity of Ni NPs. JF - PloS one AU - Gu, Yuanliang AU - Wang, Yafei AU - Zhou, Qi AU - Bowman, Linda AU - Mao, Guochuan AU - Zou, Baobo AU - Xu, Jin AU - Liu, Yu AU - Liu, Kui AU - Zhao, Jinshun AU - Ding, Min AD - Department of Preventative Medicine, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Medicine School of Ningbo University, Ningbo, Zhejiang, China. ; Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, United States of America. ; Department of Science Research and Information Management, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 3 KW - NF-kappa B KW - 0 KW - Reactive Oxygen Species KW - Transcription Factor AP-1 KW - Nickel KW - 7OV03QG267 KW - Catechin KW - 8R1V1STN48 KW - epigallocatechin gallate KW - BQM438CTEL KW - Luciferases KW - EC 1.13.12.- KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Cell Survival -- drug effects KW - Cell Count KW - Transcription Factor AP-1 -- metabolism KW - Cell Shape -- drug effects KW - Apoptosis -- drug effects KW - Oxidative Stress -- drug effects KW - Luciferases -- metabolism KW - Mice KW - Cell Line KW - Cell Cycle -- drug effects KW - NF-kappa B -- metabolism KW - MAP Kinase Signaling System -- drug effects KW - Metal Nanoparticles -- toxicity KW - Metal Nanoparticles -- ultrastructure KW - Catechin -- analogs & derivatives KW - Nickel -- toxicity KW - Down-Regulation -- drug effects KW - Catechin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1771447242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Inhibition+of+Nickel+Nanoparticles-Induced+Toxicity+by+Epigallocatechin-3-Gallate+in+JB6+Cells+May+Be+through+Down-Regulation+of+the+MAPK+Signaling+Pathways.&rft.au=Gu%2C+Yuanliang%3BWang%2C+Yafei%3BZhou%2C+Qi%3BBowman%2C+Linda%3BMao%2C+Guochuan%3BZou%2C+Baobo%3BXu%2C+Jin%3BLiu%2C+Yu%3BLiu%2C+Kui%3BZhao%2C+Jinshun%3BDing%2C+Min&rft.aulast=Gu&rft.aufirst=Yuanliang&rft.date=2016-01-01&rft.volume=11&rft.issue=3&rft.spage=e0150954&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0150954 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-25 N1 - Date created - 2016-03-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Br J Dermatol. 1999 Oct;141(4):676-82 [10583115] Mol Cell Biol. 2000 Feb;20(3):929-35 [10629050] J Clin Invest. 2001 Feb;107(3):241-6 [11160144] Oncogene. 2001 Apr 5;20(15):1803-15 [11313928] Oncogene. 2001 Nov 29;20(55):8009-18 [11753684] Nat Cell Biol. 2002 May;4(5):E131-6 [11988758] J Biomed Sci. 2003 Mar-Apr;10(2):219-27 [12595758] Cancer Res. 2003 Nov 15;63(22):7563-70 [14633667] Mutat Res. 2003 Dec 10;533(1-2):67-97 [14643413] Nature. 2004 Sep 23;431(7007):461-6 [15329734] Br J Cancer. 1972 Aug;26(4):239-57 [4561027] Mol Cell Biol. 1994 Sep;14(9):5997-6003 [8065332] Cancer Lett. 1995 Sep 25;96(2):239-43 [7585463] Curr Opin Cell Biol. 1997 Apr;9(2):240-6 [9069263] J Toxicol Environ Health A. 1998 Mar 27;53(6):423-38 [9537280] Invest Ophthalmol Vis Sci. 2006 Dec;47(12):5267-75 [17122112] J R Soc Interface. 2006 Dec 22;3(11):767-75 [17015296] Cell Death Differ. 2007 Jun;14(6):1172-80 [17396132] Yao Xue Xue Bao. 2007 Feb;42(2):132-8 [17518039] Inhal Toxicol. 2007;19 Suppl 1:59-65 [17886052] FASEB J. 2008 Apr;22(4):954-65 [18039929] Lancet. 2009 Apr 11;373(9671):1301-9 [19328542] J Environ Pathol Toxicol Oncol. 2009;28(3):177-208 [19888907] J Nutr Biochem. 2010 Feb;21(2):140-6 [19269153] Am J Ind Med. 2010 Aug;53(8):763-7 [20623660] J Toxicol Environ Health A. 2010;73(20):1353-69 [20818535] Rev Environ Health. 2011;26(2):81-92 [21905451] Toxicol Sci. 2011 Nov;124(1):138-48 [21828359] Biochem Pharmacol. 2011 Dec 15;82(12):1807-21 [21827739] Carcinogenesis. 2011 Dec;32(12):1881-9 [21965273] PLoS One. 2011;6(11):e27730 [22110744] PLoS One. 2014;9(4):e92418 [24691273] BMC Genomics. 2014;15 Suppl 11:S3 [25559244] Environ Toxicol. 2015 Feb;30(2):137-48 [23776134] PLoS One. 2015;10(3):e0119543 [25785827] Oxid Med Cell Longev. 2015;2015:476180 [25918582] J Huazhong Univ Sci Technolog Med Sci. 2015 Jun;35(3):378-83 [26072077] PLoS One. 2015;10(9):e0138590 [26375285] Erratum In: PLoS One. 2016;11(4):e0154978 [27124002] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0150954 ER - TY - JOUR T1 - Integrated Analysis of Dysregulated ncRNA and mRNA Expression Profiles in Humans Exposed to Carbon Nanotubes. AN - 1770217985; 26930275 AB - As the application of carbon nanotubes (CNT) in consumer products continues to rise, studies have expanded to determine the associated risks of exposure on human and environmental health. In particular, several lines of evidence indicate that exposure to multi-walled carbon nanotubes (MWCNT) could pose a carcinogenic risk similar to asbestos fibers. However, to date the potential markers of MWCNT exposure are not yet explored in humans. In the present study, global mRNA and ncRNA expression profiles in the blood of exposed workers, having direct contact with MWCNT aerosol for at least 6 months (n = 8), were compared with expression profiles of non-exposed (n = 7) workers (e.g., professional and/or technical staff) from the same manufacturing facility. Significant changes in the ncRNA and mRNA expression profiles were observed between exposed and non-exposed worker groups. An integrative analysis of ncRNA-mRNA correlations was performed to identify target genes, functional relationships, and regulatory networks in MWCNT-exposed workers. The coordinated changes in ncRNA and mRNA expression profiles revealed a set of miRNAs and their target genes with roles in cell cycle regulation/progression/control, apoptosis and proliferation. Further, the identified pathways and signaling networks also revealed MWCNT potential to trigger pulmonary and cardiovascular effects as well as carcinogenic outcomes in humans, similar to those previously described in rodents exposed to MWCNTs. This study is the first to investigate aberrant changes in mRNA and ncRNA expression profiles in the blood of humans exposed to MWCNT. The significant changes in several miRNAs and mRNAs expression as well as their regulatory networks are important for getting molecular insights into the MWCNT-induced toxicity and pathogenesis in humans. Further large-scale prospective studies are necessary to validate the potential applicability of such changes in mRNAs and miRNAs as prognostic markers of MWCNT exposures in humans. JF - PloS one AU - Shvedova, Anna A AU - Yanamala, Naveena AU - Kisin, Elena R AU - Khailullin, Timur O AU - Birch, M Eileen AU - Fatkhutdinova, Liliya M AD - Exposure Assessment Branch/HELD/NIOSH/CDC, Morgantown, WV - 26505, United States of America. ; Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV -26505, United States of America. ; NIOSH/CDC, 4676 Columbia Parkway, Cincinnati, OH - 45226, United States of America. ; Department of Hygiene and Occupational Health, Kazan State Medical University, ul. Butlerova 49, Kazan, 420012 Russia. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 3 KW - Nanotubes, Carbon KW - 0 KW - RNA, Messenger KW - RNA, Untranslated KW - Index Medicus KW - Real-Time Polymerase Chain Reaction KW - Young Adult KW - Microscopy, Electron, Transmission KW - Humans KW - Adult KW - Occupational Exposure -- adverse effects KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - RNA, Untranslated -- metabolism KW - RNA, Messenger -- metabolism KW - RNA, Untranslated -- drug effects KW - RNA, Messenger -- drug effects KW - Nanotubes, Carbon -- adverse effects KW - Transcriptome -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770217985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Integrated+Analysis+of+Dysregulated+ncRNA+and+mRNA+Expression+Profiles+in+Humans+Exposed+to+Carbon+Nanotubes.&rft.au=Shvedova%2C+Anna+A%3BYanamala%2C+Naveena%3BKisin%2C+Elena+R%3BKhailullin%2C+Timur+O%3BBirch%2C+M+Eileen%3BFatkhutdinova%2C+Liliya+M&rft.aulast=Shvedova&rft.aufirst=Anna&rft.date=2016-01-01&rft.volume=11&rft.issue=3&rft.spage=e0150628&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0150628 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-02 N1 - Date created - 2016-03-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2999-3004 [14973191] Environ Health Perspect. 2005 Aug;113(8):934-46 [16079061] Toxicol Appl Pharmacol. 2005 Sep 15;207(3):221-31 [16129115] Science. 2005 Sep 2;309(5740):1570-3 [16141075] Respir Res. 2005;6:78 [16042760] Am J Physiol Lung Cell Mol Physiol. 2005 Nov;289(5):L698-708 [15951334] Am J Respir Crit Care Med. 2006 Feb 15;173(4):426-31 [16339922] Nat Rev Cancer. 2006 Apr;6(4):259-69 [16557279] Crit Rev Toxicol. 2006 Mar;36(3):189-217 [16686422] J Invest Dermatol. 2006 Jun;126(6):1388-95 [16614728] Endokrynol Pol. 2005 Sep-Oct;56(5):752-7 [16817140] Genome Biol. 2006;7 Suppl 1:S4.1-9 [16925838] Oncogene. 2006 Oct 9;25(46):6220-7 [17028602] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945] Environ Health Perspect. 2006 Dec;114(12):1818-25 [17185269] Environ Health Perspect. 2007 Mar;115(3):377-82 [17431486] Cancer Res. 2007 Apr 15;67(8):3963-9 [17440112] Cell. 2007 Jun 29;129(7):1311-23 [17604720] Nucleic Acids Res. 2007 Jul;35(Web Server issue):W169-75 [17576678] Oncogene. 2007 Sep 6;26(41):6099-105 [17384677] Toxicol Sci. 2007 Nov;100(1):203-14 [17660506] Nature. 2008 Jan 10;451(7175):202-6 [18185590] Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L87-97 [18024722] J Nanosci Nanotechnol. 2007 Dec;7(12):4607-11 [18283852] Carcinogenesis. 2008 Feb;29(2):427-33 [18174261] Cell Res. 2008 Mar;18(3):350-9 [18270520] J Cell Mol Med. 2009 Jan;13(1):39-53 [19175699] Nature. 2009 Mar 12;458(7235):223-7 [19182780] Inhal Toxicol. 2009 Jul;21 Suppl 1:68-73 [19558236] Cancer Res. 2009 Jul 1;69(13):5553-9 [19549910] Nat Nanotechnol. 2009 Jul;4(7):451-6 [19581899] Inhal Toxicol. 2008 Jun;20(8):741-9 [18569096] Biochem Biophys Res Commun. 2008 Aug 8;372(4):691-6 [18538132] Toxicol Lett. 2006 Jan 5;160(2):121-6 [16125885] Nature. 2008 Jul 3;454(7200):126-30 [18509338] Nat Nanotechnol. 2008 Jul;3(7):423-8 [18654567] Tumour Biol. 2008;29(4):231-44 [18781095] Cell Res. 2008 Oct;18(10):997-1006 [18766170] Nucleic Acids Res. 2009 Jan;37(Database issue):D105-10 [18996891] Nat Protoc. 2009;4(1):44-57 [19131956] Nano Lett. 2009 Jan;9(1):36-43 [19049393] Toxicol Lett. 2009 Feb 10;184(3):192-7 [19063954] Bioinformatics. 2009 Aug 1;25(15):1991-3 [19435746] Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11667-72 [19571010] Curr Protoc Bioinformatics. 2009 Sep;Chapter 13:Unit 13.11 [19728287] Environ Mol Mutagen. 2009 Oct;50(8):708-17 [19774611] Inhal Toxicol. 2010 Apr;22(5):369-81 [20121582] Toxicology. 2010 Mar 10;269(2-3):136-47 [19857541] Cell Biol Int. 2010 May;34(5):493-502 [20121701] Part Fibre Toxicol. 2010;7:5 [20307263] Cell. 2010 Oct 1;143(1):46-58 [20887892] Part Fibre Toxicol. 2010;7:28 [20920331] Nucleic Acids Res. 2011 Jan;39(Database issue):D876-82 [20959295] Nucleic Acids Res. 2011 Jan;39(Database issue):D202-9 [21037263] Toxicol Sci. 2011 Mar;120(1):123-35 [21135415] Toxicol Appl Pharmacol. 2011 Apr 1;252(1):1-10 [21310169] Am J Pathol. 2011 Jun;178(6):2587-600 [21641383] Nano Lett. 2011 Jul 13;11(7):2796-803 [21657258] Part Fibre Toxicol. 2011;8:21 [21781304] Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2262-72 [21828236] Nat Rev Genet. 2011 Dec;12(12):861-74 [22094949] Chem Res Toxicol. 2011 Dec 19;24(12):2237-48 [22081859] Nucleic Acids Res. 2012 Jan;40(Database issue):D222-9 [22135297] Arch Toxicol. 2012 Apr;86(4):553-62 [22076105] Mol Med Rep. 2012 Jun;5(6):1514-20 [22406928] Respir Investig. 2012 Mar;50(1):3-13 [22554854] Mutat Res. 2012 Jun 14;745(1-2):28-37 [22178868] Nucleic Acids Res. 2012 Jul;40(Web Server issue):W498-504 [22649059] Biochem Soc Trans. 2012 Aug;40(4):902-6 [22817756] Part Fibre Toxicol. 2012;9:14 [22571318] Genome Biol. 2012;13(9):R51 [22951037] PLoS One. 2015;10(5):e0125026 [25965386] Ann Occup Hyg. 2015 Jul;59(6):705-23 [25851309] Toxicol In Vitro. 2015 Oct;29(7):1298-308 [25998161] Oncotarget. 2015 Sep 15;6(27):23055-7 [26405161] J Appl Toxicol. 2016 Jan;36(1):161-74 [25926378] Part Fibre Toxicol. 2012;9:38 [23072542] Small. 2013 May 27;9(9-10):1691-5 [22996965] FEBS Lett. 2013 Sep 17;587(18):3153-7 [23954293] Toxicol Appl Pharmacol. 2013 Oct 15;272(2):476-89 [23845593] Nanotoxicology. 2013 Nov;7(7):1179-94 [22881873] Cell Death Differ. 2013 Dec;20(12):1603-14 [24212931] Nanotoxicology. 2014 Aug;8(5):485-507 [23634900] Nucleic Acids Res. 2014 Jan;42(Database issue):D756-63 [24259432] Nucleic Acids Res. 2014 Jan;42(Database issue):D92-7 [24297251] Part Fibre Toxicol. 2014;11:3 [24405760] Toxicol Sci. 2014 Mar;138(1):104-16 [24431218] Biomed Res Int. 2014;2014:518609 [24707488] Oncotarget. 2014 Jun 15;5(11):3541-54 [24939878] PLoS One. 2014;9(8):e103698 [25084400] Nanotoxicology. 2014 Aug;8 Suppl 1:100-10 [24295335] Biomed Res Int. 2014;2014:756975 [25309923] PLoS One. 2014;9(11):e113401 [25406082] Lancet Oncol. 2014 Dec;15(13):1427-8 [25499275] Nanomedicine (Lond). 2015 Feb;10(3):351-60 [24823432] Toxicol Appl Pharmacol. 2015 Apr 1;284(1):16-32 [25554681] Cancer Res. 2015 Apr 15;75(8):1615-23 [25744719] Mol Biol (Mosk). 2015 Jan-Feb;49(1):55-66 [25916110] J Med Invest. 1999 Aug;46(3-4):151-8 [10687309] Circulation. 2002 Jan 29;105(4):411-4 [11815420] Cell Tissue Res. 2003 Jan;311(1):47-51 [12483283] J Immunol. 2003 Jun 1;170(11):5704-11 [12759453] Cell. 2003 Dec 26;115(7):787-98 [14697198] Toxicol Sci. 2004 Jan;77(1):126-34 [14514958] Toxicol Sci. 2004 Jan;77(1):117-25 [14514968] Cell. 2004 Jan 23;116(2):281-97 [14744438] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0150628 ER - TY - JOUR T1 - Dietary Iodine Sufficiency and Moderate Insufficiency in the Lactating Mother and Nursing Infant: A Computational Perspective. AN - 1770217628; 26930410 AB - The Institute of Medicine recommends that lactating women ingest 290 μg iodide/d and a nursing infant, less than two years of age, 110 μg/d. The World Health Organization, United Nations Children's Fund, and International Council for the Control of Iodine Deficiency Disorders recommend population maternal and infant urinary iodide concentrations ≥ 100 μg/L to ensure iodide sufficiency. For breast milk, researchers have proposed an iodide concentration range of 150-180 μg/L indicates iodide sufficiency for the mother and infant, however no national or international guidelines exist for breast milk iodine concentration. For the first time, a lactating woman and nursing infant biologically based model, from delivery to 90 days postpartum, was constructed to predict maternal and infant urinary iodide concentration, breast milk iodide concentration, the amount of iodide transferred in breast milk to the nursing infant each day and maternal and infant serum thyroid hormone kinetics. The maternal and infant models each consisted of three sub-models, iodide, thyroxine (T4), and triiodothyronine (T3). Using our model to simulate a maternal intake of 290 μg iodide/d, the average daily amount of iodide ingested by the nursing infant, after 4 days of life, gradually increased from 50 to 101 μg/day over 90 days postpartum. The predicted average lactating mother and infant urinary iodide concentrations were both in excess of 100 μg/L and the predicted average breast milk iodide concentration, 157 μg/L. The predicted serum thyroid hormones (T4, free T4 (fT4), and T3) in both the nursing infant and lactating mother were indicative of euthyroidism. The model was calibrated using serum thyroid hormone concentrations for lactating women from the United States and was successful in predicting serum T4 and fT4 levels (within a factor of two) for lactating women in other countries. T3 levels were adequately predicted. Infant serum thyroid hormone levels were adequately predicted for most data. For moderate iodide deficient conditions, where dietary iodide intake may range from 50 to 150 μg/d for the lactating mother, the model satisfactorily described the iodide measurements, although with some variation, in urine and breast milk. Predictions of serum thyroid hormones in moderately iodide deficient lactating women (50 μg/d) and nursing infants did not closely agree with mean reported serum thyroid hormone levels, however, predictions were usually within a factor of two. Excellent agreement between prediction and observation was obtained for a recent moderate iodide deficiency study in lactating women. Measurements included iodide levels in urine of infant and mother, iodide in breast milk, and serum thyroid hormone levels in infant and mother. A maternal iodide intake of 50 μg/d resulted in a predicted 29-32% reduction in serum T4 and fT4 in nursing infants, however the reduced serum levels of T4 and fT4 were within most of the published reference intervals for infant. This biologically based model is an important first step at integrating the rapid changes that occur in the thyroid system of the nursing newborn in order to predict adverse outcomes from exposure to thyroid acting chemicals, drugs, radioactive materials or iodine deficiency. JF - PloS one AU - Fisher, W AU - Wang, Jian AU - George, Nysia I AU - Gearhart, Jeffery M AU - McLanahan, Eva D AD - US FDA, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, Arkansas, 72079, United States of America. ; US FDA, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, Silver Springs, Maryland, 20993, United States of America. ; The Henry M. Jackson Foundation for the Advancement of Military Medicine, 2729 R Street, Bldg 837, Wright-Patterson AFB, Ohio, 43433, United States of America. ; CDC/ATSDR, Division of Community Health Investigations, 4770 Buford HWY NE, Atlanta, Georgia, 30341, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 3 KW - Iodides KW - 0 KW - Triiodothyronine KW - 06LU7C9H1V KW - Thyroxine KW - Q51BO43MG4 KW - Index Medicus KW - Computer Simulation KW - Triiodothyronine -- blood KW - Humans KW - Infant, Newborn KW - Thyroxine -- blood KW - Models, Biological KW - Female KW - Milk, Human -- chemistry KW - Iodides -- administration & dosage KW - Breast Feeding KW - Iodides -- analysis KW - Dietary Supplements -- analysis KW - Iodides -- urine KW - Lactation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1770217628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Dietary+Iodine+Sufficiency+and+Moderate+Insufficiency+in+the+Lactating+Mother+and+Nursing+Infant%3A+A+Computational+Perspective.&rft.au=Fisher%2C+W%3BWang%2C+Jian%3BGeorge%2C+Nysia+I%3BGearhart%2C+Jeffery+M%3BMcLanahan%2C+Eva+D&rft.aulast=Fisher&rft.aufirst=W&rft.date=2016-01-01&rft.volume=11&rft.issue=3&rft.spage=e0149300&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0149300 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-21 N1 - Date created - 2016-03-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Thyroid. 2013 Aug;23(8):927-37 [23488982] Ann Neurol. 2013 Nov;74(5):733-42 [23943579] Risk Anal. 2014 Feb;34(2):356-66 [23901895] Lancet Diabetes Endocrinol. 2014 Mar;2(3):197-209 [24622750] BMC Cancer. 2014;14:303 [24884806] Pediatrics. 2014 Jun;133(6):1163-6 [24864180] Thyroid. 2014 Aug;24(8):1309-13 [24801116] Zhonghua Zhong Liu Za Zhi. 2014 Sep;36(9):677-81 [25564058] Mol Cell Endocrinol. 2015 Sep 5;412:26-35 [26027918] Endocr J. 2015;62(10):855-6 [26211473] Mol Neurobiol. 2016 Apr;53(3):1613-24 [25666160] Endocrinol Exp. 1983 Oct;17(3-4):219-35 [6360658] Arch Dis Child. 1985 Feb;60(2):141-4 [3977386] Am J Dis Child. 1986 Sep;140(9):933-6 [3740001] Eur J Obstet Gynecol Reprod Biol. 1990 May-Jun;35(2-3):179-82 [2335252] Pediatrics. 1991 Jun;87(6):829-37 [2034486] Exp Physiol. 1992 Jan;77(1):79-87 [1543594] J Endocrinol Invest. 1992 Feb;15(2):137-42 [1569290] Risk Anal. 1994 Aug;14(4):521-31 [7972956] Clin Chem. 1996 Jan;42(1):135-9 [8565215] Health Phys. 1997 Mar;72(3):368-83 [9030838] J Clin Endocrinol Metab. 1998 Aug;83(8):2868-74 [9709961] Thyroid. 1998 Dec;8(12):1185-92 [9920376] J Clin Endocrinol Metab. 1963 Aug;23:811-9 [14059559] J Clin Endocrinol Metab. 1964 Jul;24:628-37 [14212082] Clin Sci. 1964 Oct;27:195-207 [14220900] J Clin Endocrinol Metab. 2004 Nov;89(11):5314-20 [15531476] Toxicol Sci. 2005 Jan;83(1):25-43 [15509666] J Anat. 2005 Jun;206(6):525-34 [15960763] J Clin Endocrinol Metab. 2005 Aug;90(8):4599-606 [15886240] Pediatrics. 2006 Jan;117(1):161-7 [16396874] Pediatrics. 2006 Mar;117(3):e387-95 [16510619] Clin Pharmacokinet. 2006;45(10):1013-34 [16984214] J Toxicol Environ Health A. 2007 Mar 1;70(5):408-28 [17454566] J Clin Endocrinol Metab. 2007 May;92(5):1673-7 [17311853] Ther Drug Monit. 2007 Oct;29(5):553-9 [17898643] Br J Nutr. 2008 Apr;99(4):813-8 [17961291] Toxicol Sci. 2008 Apr;102(2):241-53 [18178547] Obstet Gynecol. 2008 Jul;112(1):85-92 [18591312] J Expo Sci Environ Epidemiol. 2008 Nov;18(6):571-80 [18167505] Biol Trace Elem Res. 2009 Jan;127(1):6-15 [18802672] Thyroid. 2009 Feb;19(2):157-63 [18976166] Thyroid. 2009 May;19(5):511-9 [19348584] Environ Health Perspect. 2009 May;117(5):731-8 [19479014] Clin Endocrinol (Oxf). 2010 Jun;72(6):825-9 [19878506] Environ Health Perspect. 2010 Sep;118(9):1332-7 [20439182] Thyroid. 2010 Sep;20(9):995-1001 [20629555] Am J Clin Nutr. 2010 Oct;92(4):849-56 [20702609] J Pediatr Endocrinol Metab. 2010 Sep;23(9):899-912 [21175089] Ann Clin Biochem. 2011 Jan;48(Pt 1):7-22 [20930033] Thyroid. 2011 Apr;21(4):419-27 [21323596] Horm Metab Res. 2011 Jun;43(6):422-6 [21484669] Crit Rev Toxicol. 2012 May;42(5):323-57 [22512665] Thyroid. 2012 Sep;22(9):938-43 [22827469] J Clin Endocrinol Metab. 2012 Sep;97(9):3170-8 [22736771] Toxicol Sci. 2013 Mar;132(1):177-95 [23288053] Toxicol Sci. 2013 Mar;132(1):75-86 [23288054] Eur J Endocrinol. 2013 May;168(5):723-31 [23444413] Eur J Clin Nutr. 2000 May;54(5):429-33 [10822292] Nutr Rev. 2001 Aug;59(8 Pt 1):269-78 [11518182] J Urol. 2001 Dec;166(6):2376-81 [11696790] Clin Chem Lab Med. 2001 Oct;39(10):973-9 [11758614] Ann Anat. 2002 Mar;184(2):181-4 [11936199] Clin Endocrinol (Oxf). 2002 May;56(5):621-7 [12030913] J Trace Elem Med Biol. 2002;16(4):207-20 [12530582] J Clin Endocrinol Metab. 1966 Apr;26(4):425-36 [5929629] J Clin Endocrinol Metab. 1966 Dec;26(12):1392-4 [5959529] J Clin Invest. 1975 Jun;55(6):1137-41 [1133163] J Clin Chem Clin Biochem. 1976 Dec;14(12):595-601 [1010989] Acta Paediatr Scand. 1982 Nov;71(6):953-8 [7158334] J Clin Endocrinol Metab. 1978 Jul;47(1):189-92 [263290] Pediatr Res. 1983 Jun;17(6):468-71 [6877900] Toxicol Sci. 2013 Jun;133(2):320-41 [23535361] Clin Endocrinol (Oxf). 2013 Aug;79(2):152-62 [23600900] Erratum In: PLoS One. 2016;11(5):e0155169 [27136902] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0149300 ER - TY - JOUR T1 - Trans fat and cardiovascular disease mortality: Evidence from bans in restaurants in New York AN - 1768584087; PQ0002690415 AB - This paper analyzes the impact of trans fat bans on cardiovascular disease (CVD) mortality rates. Several New York State jurisdictions have restricted the use of ingredients containing artificial trans fat in food service establishments. The resulting within-county variation over time and the differential timing of the policy's rollout is used in estimation. The results indicate that the policy caused a 4.5% reduction in CVD mortality rates, or 13 fewer CVD deaths per 100,000 persons per year. The averted deaths can be valued at about $3.9 million per 100,000 persons annually. JF - Journal of Health Economics AU - Restrepo, Brandon J AU - Rieger, Matthias AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, United States Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 176 EP - 196 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 45 SN - 0167-6296, 0167-6296 KW - Health & Safety Science Abstracts KW - I12 KW - I18 KW - Trans fat KW - Restaurant KW - Ban KW - Cardiovascular disease KW - Mortality KW - ANW, USA, New York KW - Economics KW - Cardiovascular diseases KW - State jurisdiction KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768584087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Economics&rft.atitle=Trans+fat+and+cardiovascular+disease+mortality%3A+Evidence+from+bans+in+restaurants+in+New+York&rft.au=Restrepo%2C+Brandon+J%3BRieger%2C+Matthias&rft.aulast=Restrepo&rft.aufirst=Brandon&rft.date=2016-01-01&rft.volume=45&rft.issue=&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Economics&rft.issn=01676296&rft_id=info:doi/10.1016%2Fj.jhealeco.2015.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Mortality; Economics; State jurisdiction; Cardiovascular diseases; ANW, USA, New York DO - http://dx.doi.org/10.1016/j.jhealeco.2015.09.005 ER - TY - JOUR T1 - Development of a Flow Cytometry-Based Method for Rapid Detection of Escherichia coli and Shigella Spp. Using an Oligonucleotide Probe. AN - 1768564743; 26913737 AB - Standard methods to detect Escherichia coli contamination in food use the polymerase chain reaction (PCR) and agar culture plates. These methods require multiple incubation steps and take a long time to results. An improved rapid flow-cytometry based detection method was developed, using a fluorescence-labeled oligonucleotide probe specifically binding a16S rRNA sequence. The method positively detected 51 E. coli isolates as well as 4 Shigella species. All 27 non-E. coli strains tested gave negative results. Comparison of the new genetic assay with a total plate count (TPC) assay and agar plate counting indicated similar sensitivity, agreement between cytometry cell and colony counts. This method can detect a small number of E.coli cells in the presence of large numbers of other bacteria. This method can be used for rapid, economical, and stable detection of E. coli and Shigella contamination in the food industry and other contexts. JF - PloS one AU - Xue, Yong AU - Wilkes, Jon G AU - Moskal, Ted J AU - Williams, Anna J AU - Cooper, Willie M AU - Nayak, Rajesh AU - Rafii, Fatemeh AU - Buzatu, Dan A AD - Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, United States of America. ; Life Sciences Consultant, 515 W. Matthews Ave., Jonesboro, AR, United States of America. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, United States of America. Y1 - 2016 PY - 2016 DA - 2016 SP - 1 VL - 11 IS - 2 KW - Oligonucleotide Probes KW - 0 KW - RNA, Ribosomal, 16S KW - Index Medicus KW - Dysentery, Bacillary -- microbiology KW - Escherichia coli Infections -- microbiology KW - RNA, Ribosomal, 16S -- genetics KW - Humans KW - Foodborne Diseases -- microbiology KW - Dysentery, Bacillary -- prevention & control KW - Foodborne Diseases -- prevention & control KW - Escherichia coli Infections -- prevention & control KW - Shigella -- genetics KW - Oligonucleotide Probes -- genetics KW - Escherichia coli O157 -- isolation & purification KW - Food Contamination -- analysis KW - Shigella -- isolation & purification KW - Flow Cytometry -- methods KW - Escherichia coli O157 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768564743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Development+of+a+Flow+Cytometry-Based+Method+for+Rapid+Detection+of+Escherichia+coli+and+Shigella+Spp.+Using+an+Oligonucleotide+Probe.&rft.au=Xue%2C+Yong%3BWilkes%2C+Jon+G%3BMoskal%2C+Ted+J%3BWilliams%2C+Anna+J%3BCooper%2C+Willie+M%3BNayak%2C+Rajesh%3BRafii%2C+Fatemeh%3BBuzatu%2C+Dan+A&rft.aulast=Xue&rft.aufirst=Yong&rft.date=2016-01-01&rft.volume=11&rft.issue=2&rft.spage=e0150038&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0150038 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-08 N1 - Date created - 2016-02-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Public Health Rep. 2005 Mar-Apr;120(2):174-8 [15842119] Emerg Infect Dis. 2005 Apr;11(4):603-9 [15829201] Clin Infect Dis. 2009 Apr 15;48(8):1079-86 [19265476] Int J Food Microbiol. 2010 May 30;139 Suppl 1:S3-15 [20153070] J Microbiol Methods. 2010 Sep;82(3):301-10 [20638420] J Food Prot. 2010 Sep;73(9):1721-36 [20828483] Food Microbiol. 2012 May;30(1):281-8 [22265313] Clin Infect Dis. 2012 Feb 15;54(4):511-8 [22157169] Food Microbiol. 2013 Dec;36(2):416-25 [24010624] PLoS One. 2014;9(4):e94254 [24718659] Mol Microbiol. 2002 Mar;43(5):1269-83 [11918812] Microbes Infect. 2002 Sep;4(11):1125-32 [12361912] Appl Environ Microbiol. 1990 Jun;56(6):1919-25 [2200342] MMWR Morb Mortal Wkly Rep. 1996 Nov 8;45(44):975 [8965797] Microbiol Rev. 1996 Dec;60(4):641-96 [8987359] Nat Biotechnol. 1998 Aug;16(8):743-7 [9702772] Annu Rev Med. 1999;50:355-67 [10073283] J Bacteriol. 1949 Jun;57(6):633-8 [16561743] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0150038 ER - TY - JOUR T1 - Effects of nickel-oxide nanoparticle pre-exposure dispersion status on bioactivity in the mouse lung. AN - 1768558832; 25916264 AB - Nanotechnology is emerging as one of the world's most promising new technologies. From a toxicology perspective, nanoparticles possess two features that promote their bioactivity. The first involves physical-chemical characteristics of the nanoparticle, which include the surface area of the nanoparticle. The second feature is the ability of the nanoparticle to traverse cell membranes. These two important nanoparticle characteristics are greatly influenced by placing nanoparticles in liquid medium prior to animal exposure. Nanoparticles tend to agglomerate and clump in suspension, making it difficult to reproducibly deliver them for in vivo or in vitro experiments, possibly affecting experimental variability. Thus, we hypothesize that nanoparticle dispersion status will correlate with the in vivo bioactivity/toxicity of the particle. To test our hypothesis, nano-sized nickel oxide was suspended in four different dispersion media (phosphate-buffered saline (PBS), dispersion medium (DM), a combination of dipalmitoyl-phosphatidyl choline (DPPC) and albumin in concentrations that mimic diluted alveolar lining fluid), Survanta®, or pluronic (Pluronic F-68). Well-dispersed and poorly dispersed suspensions were generated in each media by varying sonication time on ice utilizing a Branson Sonifer 450 (25W continuous output, 20 min or 5 min, respectively). Mice (male, C57BL/6J, 7-weeks-old) were given 0-80 µg/mouse of nano-sized nickel oxide in the different states of dispersion via pharyngeal aspiration. At 1 and 7 d post-exposure, mice underwent whole lung lavage to assess pulmonary inflammation and injury as a function of dispersion status, dose and time. The results show that pre-exposure dispersion status correlates with pulmonary inflammation and injury. These results indicate that a greater degree of pre-exposure dispersion increases pulmonary inflammation and cytotoxicity, as well as decreases in the integrity of the blood-gas barrier in the lung. JF - Nanotoxicology AU - Sager, Tina AU - Wolfarth, Michael AU - Keane, Michael AU - Porter, Dale AU - Castranova, Vincent AU - Holian, Andrij AD - a Department of Biomedical and Pharmaceutical Sciences , Center for Environmental Health Sciences, University of Montana , Missoula , MT , USA . ; b National Institute for Occupational Safety and Health, Health Effects Laboratory Division , Pathology and Physiology Research Branch , Morgantown , WV , USA , and. Y1 - 2016 PY - 2016 DA - 2016 SP - 151 EP - 161 VL - 10 IS - 2 KW - Biological Products KW - 0 KW - Suspensions KW - Poloxamer KW - 106392-12-5 KW - 1,2-Dipalmitoylphosphatidylcholine KW - 2644-64-6 KW - Sodium Chloride KW - 451W47IQ8X KW - Nickel KW - 7OV03QG267 KW - nickel monoxide KW - C3574QBZ3Y KW - beractant KW - S866O45PIG KW - Index Medicus KW - nanotoxicology KW - particle toxicology KW - toxicology KW - particle characterization KW - Nanoparticles KW - Animals KW - Dose-Response Relationship, Drug KW - Particle Size KW - Suspensions -- toxicity KW - Sodium Chloride -- administration & dosage KW - Thoracentesis KW - Mice KW - Sonication KW - Poloxamer -- toxicity KW - Sodium Chloride -- toxicity KW - Suspensions -- administration & dosage KW - Biological Products -- administration & dosage KW - 1,2-Dipalmitoylphosphatidylcholine -- administration & dosage KW - 1,2-Dipalmitoylphosphatidylcholine -- toxicity KW - Poloxamer -- pharmacology KW - Biological Products -- toxicity KW - Poloxamer -- administration & dosage KW - Male KW - Lung -- drug effects KW - Nickel -- toxicity KW - Lung -- pathology KW - Lung -- metabolism KW - Nickel -- chemistry KW - Nanoparticles -- toxicity KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768558832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Effects+of+nickel-oxide+nanoparticle+pre-exposure+dispersion+status+on+bioactivity+in+the+mouse+lung.&rft.au=Sager%2C+Tina%3BWolfarth%2C+Michael%3BKeane%2C+Michael%3BPorter%2C+Dale%3BCastranova%2C+Vincent%3BHolian%2C+Andrij&rft.aulast=Sager&rft.aufirst=Tina&rft.date=2016-01-01&rft.volume=10&rft.issue=2&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2015.1025883 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-02-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/17435390.2015.1025883 ER - TY - JOUR T1 - 7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids. AN - 1768167096; 26761716 AB - Pyrrolizidine alkaloids (PAs) require metabolic activation to exert cytotoxicity, genotoxicity, and tumorigenicity. We previously reported that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts are responsible for PA-induced liver tumor formation in rats. In this study, we determined that metabolism of riddelliine and monocrotaline by human or rat liver microsomes produced 7-cysteine-DHP and DHP. The metabolism of 7-glutathionyl-DHP by human and rat liver microsomes also generated 7-cysteine-DHP. Further, reaction of 7-cysteine-DHP with calf thymus DNA in aqueous solution yielded the described DHP-derived DNA adducts. This study represents the first report that 7-cysteine-DHP is a new PA metabolite that can lead to DNA adduct formation. JF - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews AU - He, Xiaobo AU - Xia, Qingsu AU - Ma, Liang AU - Fu, Peter P AD - a National Center for Toxicological Research, US Food and Drug Administration , Jefferson , Arkansas , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 57 EP - 76 VL - 34 IS - 1 KW - DNA Adducts KW - 0 KW - Pyrrolizidine Alkaloids KW - riddelliine KW - 23246-96-0 KW - Monocrotaline KW - 73077K8HYV KW - DNA KW - 9007-49-2 KW - calf thymus DNA KW - 91080-16-9 KW - Glutathione KW - GAN16C9B8O KW - Cysteine KW - K848JZ4886 KW - dehydroretronecine KW - QG6MWR17OH KW - Index Medicus KW - metabolic activation KW - 7-cysteine-DHP adducts KW - Pyrrolizidine alkaloid KW - DNA adduct formation KW - Monocrotaline -- metabolism KW - Animals KW - Rats, Inbred F344 KW - Monocrotaline -- pharmacokinetics KW - Monocrotaline -- analogs & derivatives KW - DNA Adducts -- chemistry KW - Humans KW - Glutathione -- metabolism KW - DNA -- metabolism KW - Glutathione -- analysis KW - Tandem Mass Spectrometry KW - Male KW - DNA Adducts -- metabolism KW - Pyrrolizidine Alkaloids -- pharmacokinetics KW - Cysteine -- metabolism KW - Cysteine -- chemistry KW - Microsomes, Liver -- metabolism KW - Microsomes, Liver -- drug effects KW - Pyrrolizidine Alkaloids -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768167096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=7-cysteine-pyrrole+conjugate%3A+A+new+potential+DNA+reactive+metabolite+of+pyrrolizidine+alkaloids.&rft.au=He%2C+Xiaobo%3BXia%2C+Qingsu%3BMa%2C+Liang%3BFu%2C+Peter+P&rft.aulast=He&rft.aufirst=Xiaobo&rft.date=2016-01-01&rft.volume=34&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=1532-4095&rft_id=info:doi/10.1080%2F10590501.2015.1135593 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-11-04 N1 - Date created - 2016-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/10590501.2015.1135593 ER - TY - BOOK T1 - The Effect of a 1999 Rule Change on Obesity as a Factor in Social Security Disability Determinations AN - 1767319074; 2011-911801 AB - This paper explores the effect of a 1999 rule change by the Social Security Administration (SSA) in the treatment of obesity for purposes of making a determination of disability among new applicants to Social Security Disability Insurance (SSDI) and Supplemental Security Income (SSI). In that year, SSA removed the adult listing of obesity in the Listing of Impairments, reflecting the agency's experience that many with obesity who met the listing's requirements did not meet the functional limitation standards consistent with benefit eligibility. The implication of this change was that new applicants to SSDI and SSI were no longer determined to meet the listings based on their obesity alone. After the change, there was an immediate and sharp decline in the number of applications with obesity recorded as the primary impairment after the 1999 rule change. Despite this initial decline, obesity has increasingly been recorded as an impairment since that time, though predominantly as a secondary impairment. Because of the high prevalence of obesity in the US, obesity will undoubtedly continue to be an important consideration in reduced functional capacity among disability applicants. The 1999 policy change seems to have placed additional burden on adjudicators in making decisions on cases for obese applicants. Tables, Figures, References. JF - Mathematica Policy Research, Inc., Jan 2016, 43 pp. AU - Stahl, Anne AU - Hyde, Jody Schimmel AU - Singh, Harnam Y1 - 2016/01// PY - 2016 DA - January 2016 PB - Mathematica Policy Research, Inc. KW - United States KW - Obesity KW - United States Social security administration KW - Disabled KW - Standards KW - Regulation KW - Benefits KW - Decision-making KW - Social insurance KW - book UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1767319074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PAIS+Index&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Stahl%2C+Anne%3BHyde%2C+Jody+Schimmel%3BSingh%2C+Harnam&rft.aulast=Stahl&rft.aufirst=Anne&rft.date=2016-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=The+Effect+of+a+1999+Rule+Change+on+Obesity+as+a+Factor+in+Social+Security+Disability+Determinations&rft.title=The+Effect+of+a+1999+Rule+Change+on+Obesity+as+a+Factor+in+Social+Security+Disability+Determinations&rft.issn=&rft_id=info:doi/ L2 - http://www.mathematica-mpr.com/~/media/publications/pdfs/disability/2016/drc%20obesity%20wp%202016%2001.pdf LA - English DB - PAIS Index N1 - Date revised - 2016-03-01 N1 - Publication note - Mathematica Policy Research, Inc., 2016 N1 - Last updated - 2016-09-28 ER - TY - JOUR T1 - Whole-Genome Sequencing Analysis Accurately Predicts Antimicrobial Resistance Phenotypes in Campylobacter spp. AN - 1762373618; PQ0002481085 AB - The objectives of this study were to identify antimicrobial resistance genotypes for Campylobacter and to evaluate the correlation between resistance phenotypes and genotypes using in vitro antimicrobial susceptibility testing and whole-genome sequencing (WGS). A total of 114 Campylobacter species isolates (82 C. coli and 32 C. jejuni) obtained from 2000 to 2013 from humans, retail meats, and cecal samples from food production animals in the United States as part of the National Antimicrobial Resistance Monitoring System were selected for study. Resistance phenotypes were determined using broth microdilution of nine antimicrobials. Genomic DNA was sequenced using the Illumina MiSeq platform, and resistance genotypes were identified using assembled WGS sequences through blastx analysis. Eighteen resistance genes, including tet(O), blaOXA-61, catA, lnu(C), aph(2 double prime )-Ib, aph(2 double prime )-Ic, aph(2')-If, aph(2 double prime )-Ig, aph(2 double prime )-Ih, aac(6')-Ie-aph(2 double prime )-Ia, aac(6')-Ie-aph(2 double prime )-If, aac(6')-Im, aadE, sat4, ant(6'), aad9, aph(3')-Ic, and aph(3')-IIIa, and mutations in two housekeeping genes (gyrA and 23S rRNA) were identified. There was a high degree of correlation between phenotypic resistance to a given drug and the presence of one or more corresponding resistance genes. Phenotypic and genotypic correlation was 100% for tetracycline, ciprofloxacin/nalidixic acid, and erythromycin, and correlations ranged from 95.4% to 98.7% for gentamicin, azithromycin, clindamycin, and telithromycin. All isolates were susceptible to florfenicol, and no genes associated with florfenicol resistance were detected. There was a strong correlation (99.2%) between resistance genotypes and phenotypes, suggesting that WGS is a reliable indicator of resistance to the nine antimicrobial agents assayed in this study. WGS has the potential to be a powerful tool for antimicrobial resistance surveillance programs. JF - Antimicrobial Agents & Chemotherapy AU - Zhao, S AU - Tyson, G H AU - Chen, Y AU - Li, C AU - Mukherjee, S AU - Young, S AU - Lam, C AU - Folster, J P AU - Whichard, J M AU - McDermott, P F AD - << + $0, shaohua.zhao@fda.hhs.gov. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 459 EP - 466 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 2 SN - 0099-2240, 0099-2240 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clindamycin KW - rRNA 23S KW - Food KW - Nucleotide sequence KW - Drug resistance KW - Campylobacter KW - Genotypes KW - Erythromycin KW - Tetracyclines KW - Telithromycin KW - Antimicrobial agents KW - Gentamicin KW - Meat KW - Ciprofloxacin KW - rRNA KW - Azithromycin KW - Florfenicol KW - Nalidixic acid KW - Cecum KW - genomics KW - Mutation KW - A 01330:Food Microbiology KW - N 14830:RNA KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762373618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Whole-Genome+Sequencing+Analysis+Accurately+Predicts+Antimicrobial+Resistance+Phenotypes+in+Campylobacter+spp.&rft.au=Zhao%2C+S%3BTyson%2C+G+H%3BChen%2C+Y%3BLi%2C+C%3BMukherjee%2C+S%3BYoung%2C+S%3BLam%2C+C%3BFolster%2C+J+P%3BWhichard%2C+J+M%3BMcDermott%2C+P+F&rft.aulast=Zhao&rft.aufirst=S&rft.date=2016-01-01&rft.volume=82&rft.issue=2&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02873-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 37 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Clindamycin; rRNA 23S; Drug resistance; Nucleotide sequence; Food; Genotypes; Tetracyclines; Erythromycin; Telithromycin; Antimicrobial agents; Meat; Gentamicin; rRNA; Ciprofloxacin; Azithromycin; Nalidixic acid; Florfenicol; Cecum; genomics; Mutation; Campylobacter DO - http://dx.doi.org/10.1128/AEM.02873-15 ER - TY - JOUR T1 - Whole genome and normalized mRNA sequencing reveal genetic status of TK6, WTK1, and NH32 human B-lymphoblastoid cell lines AN - 1762373377; PQ0002518517 AB - Closely related TK6, WTK1, and NH32 human B-lymphoblastoid cell lines differ in their p53 functional status. These lines are used frequently in genotoxicity studies and in studies aimed at understanding the role of p53 in DNA repair. Despite their routine use, little is known about the genetic status of these cells. To provide insight into their genetic composition, we sequenced and analyzed the entire genome of TK6 cells, as well as the normalized transcriptomes of TK6, WTK1, and NH32 cells. Whole genome sequencing (WGS) identified 21,561 genes and 5.17106 small variants. Within the small variants, 50.54% were naturally occurring single nucleotide polymorphisms (SNPs) and 49.46% were mutations. The mutations were comprised of 92.97% single base-pair substitutions and 7.03% insertions or deletions (indels). The number of predicted genes, SNPs, and small mutations are similar to frequencies observed in the human population in general. Normalized mRNA-seq analysis identified the expression of transcripts bearing SNPs or mutations for TK6, WTK1, and NH32 as 2.88%, 2.04%, and 1.71%, respectively, and several of the variant transcripts identified appear to have important implications in genetic toxicology. These include a single base deletion mutation in the ferritin heavy chain gene (FTH1) resulting in a frame shift and protein truncation in TK6 that impairs iron metabolism. SNPs in the thiopurine S-methyltransferase (TPMT) gene (TPMT*3A SNP), and in the xenobiotic metabolizing enzyme, NADPH quinine oxidoreductase 1 (NQO1) gene (NQO1*2 SNP), are both associated with decreased enzyme activity. The clinically relevant TPMT*3A and NQO1*2 SNPs can make these cell lines useful in pharmacogenetic studies aimed at improving or tailoring drug treatment regimens that minimize toxicity and enhance efficacy. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Revollo, Javier AU - Petibone, Dayton M AU - McKinzie, Page AU - Knox, Bridgett AU - Morris, Suzanne M AU - Ning, Baitang AU - Dobrovolsky, Vasily N AD - Division of Genetic and Molecular Toxicology, FDA/NCTR, Jefferson, AR 72079, United States Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 60 EP - 69 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 795 SN - 1383-5718, 1383-5718 KW - Biochemistry Abstracts 2: Nucleic Acids; Environment Abstracts; Genetics Abstracts; Toxicology Abstracts KW - Next generation sequencing (NGS) KW - p53 KW - FTH1 KW - TPMT*3A KW - NQO1*2 KW - Human B-lymphoblastoid cells KW - Genomes KW - Quinine KW - Thiopurine S-methyltransferase KW - NQO1 gene KW - Xenobiotics KW - Pharmacogenetics KW - Mutagenesis KW - Gene expression KW - Gene deletion KW - Enzymatic activity KW - Drugs KW - Toxicology KW - Human populations KW - Genotoxicity KW - Enzymes KW - Toxicity KW - DNA repair KW - NADP KW - p53 protein KW - Insertion KW - Single-nucleotide polymorphism KW - DNA KW - Proteins KW - Protein turnover KW - oxidoreductase KW - Ferritin KW - Mutation KW - Iron KW - Metabolism KW - N 14820:DNA Metabolism & Structure KW - X 24360:Metals KW - G 07730:Development & Cell Cycle KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762373377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Whole+genome+and+normalized+mRNA+sequencing+reveal+genetic+status+of+TK6%2C+WTK1%2C+and+NH32+human+B-lymphoblastoid+cell+lines&rft.au=Revollo%2C+Javier%3BPetibone%2C+Dayton+M%3BMcKinzie%2C+Page%3BKnox%2C+Bridgett%3BMorris%2C+Suzanne+M%3BNing%2C+Baitang%3BDobrovolsky%2C+Vasily+N&rft.aulast=Revollo&rft.aufirst=Javier&rft.date=2016-01-01&rft.volume=795&rft.issue=&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2015.11.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Genomes; Quinine; Thiopurine S-methyltransferase; Genotoxicity; NQO1 gene; Enzymes; DNA repair; Pharmacogenetics; Mutagenesis; p53 protein; NADP; Gene expression; Gene deletion; Single-nucleotide polymorphism; Insertion; oxidoreductase; Protein turnover; Ferritin; Iron; Mutation; Drugs; Human populations; Toxicity; Xenobiotics; DNA; Proteins; Enzymatic activity; Metabolism; Toxicology DO - http://dx.doi.org/10.1016/j.mrgentox.2015.11.006 ER - TY - JOUR T1 - In vivo genotoxicity assessment of acrylamide and glycidyl methacrylate AN - 1762360878; PQ0002484118 AB - Acrylamide (ACR) and glycidyl methacrylate (GMA) are structurally related compounds used for making polymers with various properties. Both chemicals can be present in food either as a byproduct of processing or a constituent of packaging. We performed a comprehensive evaluation of ACR and GMA genotoxicity in Fisher 344 rats using repeated gavage administrations. Clastogenicity was measured by scoring micronucleated (MN) erythrocytes from peripheral blood, DNA damage in liver, bone marrow and kidneys was measured using the Comet assay, and gene mutation was measured using the red blood cell (RBC) and reticulocyte Pig-a assay. A limited histopathology evaluation was performed in order to determine levels of cytotoxicity. Doses of up to 20 mg/kg/day of ACR and up to 250 mg/kg/day of GMA were used. ACR treatment resulted in DNA damage in the liver, but not in the bone marrow. While ACR was not a clastogen, it was a weak (equivocal) mutagen in the cells of bone marrow. GMA caused DNA damage in the cells of bone marrow, liver and kidney, and induced MN reticulocytes and Pig-a mutant RBCs in a dose-dependent manner. Collectively, our data suggest that both compounds are in vivo genotoxins, but the genotoxicity of ACR is tissue specific. JF - Food and Chemical Toxicology AU - Dobrovolsky, Vasily N AU - Pacheco-Martinez, MMonserrat AU - McDaniel, LPatrice AU - Pearce, Mason G AU - Ding, Wei AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 120 EP - 127 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 87 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Red blood cells KW - Reticulocytes KW - Flow cytometry KW - Micronucleus test KW - The Pig-a assay KW - The Comet assay KW - Mutagens KW - Data processing KW - Food KW - Erythrocytes KW - Genotoxicity KW - Point mutation KW - Bone marrow KW - Peripheral blood KW - DNA damage KW - Cytotoxicity KW - Acrylamide KW - Clastogenicity KW - Kidney KW - Liver KW - Comet assay KW - Manganese KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762360878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=In+vivo+genotoxicity+assessment+of+acrylamide+and+glycidyl+methacrylate&rft.au=Dobrovolsky%2C+Vasily+N%3BPacheco-Martinez%2C+MMonserrat%3BMcDaniel%2C+LPatrice%3BPearce%2C+Mason+G%3BDing%2C+Wei&rft.aulast=Dobrovolsky&rft.aufirst=Vasily&rft.date=2016-01-01&rft.volume=87&rft.issue=&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2015.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Mutagens; Data processing; Food; Point mutation; Genotoxicity; Erythrocytes; Bone marrow; Peripheral blood; DNA damage; Cytotoxicity; Acrylamide; Clastogenicity; Liver; Kidney; Comet assay; Manganese; Reticulocytes DO - http://dx.doi.org/10.1016/j.fct.2015.12.006 ER - TY - JOUR T1 - Determination of Synthetic Cathinones in Urine Using Gas Chromatography-Mass Spectrometry Techniques. AN - 1760930153; 26410364 AB - In recent years, the abuse of synthetic cathinones has increased considerably. This study proposes a method, based on gas chromatography/mass spectrometry (GC-MS), to analyze and quantify six synthetic cathinones in urine samples: mephedrone (4-MMC), methylone (bk-MDMA), butylone, ethylone, pentylone and methylenedioxypyrovalerone (MDPV). In our procedure, the urine samples undergo solid-phase extraction (SPE) and derivatization prior to injection into the GC-MS device. Separation is performed using a HP-5MS capillary column. The use of selective ion monitoring (SIM mode) makes it is good sensitivity in this method, and the entire analysis process is within 18 min. In addition, the proposed method maintains linearity in the calibration curve from 50 to 2,000 ng/mL (r(2) > 0.995). The limit of detection of this method is 5 ng/mL, with the exception of MDPV (20 ng/mL); the limit of quantification is 20 ng/mL, with the exception of MDPV (50 ng/mL). In testing, the extraction performance of SPE was between 82.34 and 104.46%. Precision and accuracy results were satisfactory <15%. The proposed method was applied to six real urine samples, one of which was found to contain 4-MMC and bk-MDMA. Our results demonstrate the efficacy of the proposed method in the identification of synthetic cathinones in urine, with regard to the limits of detection and quantification. This method is highly repeatable and accurate. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Journal of analytical toxicology AU - Hong, Wei-Yin AU - Ko, Ya-Chun AU - Lin, Mei-Chih AU - Wang, Po-Yu AU - Chen, Yu-Pen AU - Chiueh, Lih-Ching AU - Shih, Daniel Yang-Chih AU - Chou, Hsiu-Kuan AU - Cheng, Hwei-Fang AD - Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan. ; Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan eteredu@gmail.com. PY - 2016 SP - 12 EP - 16 VL - 40 IS - 1 KW - 2-ethylammonio-1-(3,4-methylenedioxyphenyl)propane-1-one chloride KW - 0 KW - 2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one KW - 3,4-methylenedioxypyrovalerone KW - Amphetamines KW - Benzodioxoles KW - Designer Drugs KW - Ethylamines KW - Pyrrolidines KW - pentylone KW - Acetone KW - 1364PS73AF KW - Methamphetamine KW - 44RAL3456C KW - 3,4-Methylenedioxyamphetamine KW - 4764-17-4 KW - mephedrone KW - 8BA8T27317 KW - methylone KW - L4I4B1R01F KW - Index Medicus KW - Pyrrolidines -- urine KW - Reproducibility of Results KW - 3,4-Methylenedioxyamphetamine -- analogs & derivatives KW - Humans KW - Benzodioxoles -- urine KW - Calibration KW - Solid Phase Extraction KW - Ethylamines -- urine KW - Acetone -- urine KW - Methamphetamine -- urine KW - Amphetamines -- urine KW - Methamphetamine -- analogs & derivatives KW - Urinalysis KW - Limit of Detection KW - 3,4-Methylenedioxyamphetamine -- urine KW - Acetone -- analogs & derivatives KW - Gas Chromatography-Mass Spectrometry -- methods KW - Substance Abuse Detection -- standards KW - Gas Chromatography-Mass Spectrometry -- standards KW - Substance Abuse Detection -- methods KW - Designer Drugs -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760930153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Determination+of+Synthetic+Cathinones+in+Urine+Using+Gas+Chromatography-Mass+Spectrometry+Techniques.&rft.au=Hong%2C+Wei-Yin%3BKo%2C+Ya-Chun%3BLin%2C+Mei-Chih%3BWang%2C+Po-Yu%3BChen%2C+Yu-Pen%3BChiueh%2C+Lih-Ching%3BShih%2C+Daniel+Yang-Chih%3BChou%2C+Hsiu-Kuan%3BCheng%2C+Hwei-Fang&rft.aulast=Hong&rft.aufirst=Wei-Yin&rft.date=2016-01-01&rft.volume=40&rft.issue=1&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbkv108 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-26 N1 - Date created - 2016-01-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bkv108 ER - TY - JOUR T1 - Maternal occupational exposure to polycyclic aromatic hydrocarbons and craniosynostosis among offspring in the National Birth Defects Prevention Study. AN - 1760880012; 26033890 AB - Evidence in animal models and humans suggests that exposure to polycyclic aromatic hydrocarbons (PAHs) may lead to birth defects. To our knowledge, this relationship has not been evaluated for craniosynostosis, a birth defect characterized by the premature closure of sutures in the skull. We conducted a case-control study to examine associations between maternal occupational exposure to PAHs and craniosynostosis. We used data from craniosynostosis cases and control infants in the National Birth Defects Prevention Study (NBDPS) with estimated delivery dates from 1997 to 2002. Industrial hygienists reviewed occupational data from the computer-assisted telephone interview and assigned a yes/no rating of probable occupational PAH exposure for each job from 1 month before conception through delivery. We used logistic regression to assess the association between occupational exposure to PAHs and craniosynostosis. The prevalence of exposure was 5.3% in case mothers (16/300) and 3.7% in control mothers (107/2,886). We observed a positive association between exposure to PAHs during the 1 month before conception through the third month of pregnancy and craniosynostosis (odds ratio [OR] = 1.75; 95% confidence interval [CI], 1.01-3.05) after adjusting for maternal age and maternal education. The number of cases for each craniosynostosis subtype limited subtype analyses to sagittal craniosynostosis; the odds ratio remained similar (OR = 1.76, 95% CI, 0.82-3.75), but was not significant. Our findings support a moderate association between maternal occupational exposure to PAHs and craniosynostosis. Additional work is needed to better characterize susceptibility and the role PAHs may play on specific craniosynostosis subtypes. © 2015 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - O'Brien, Jacqueline L AU - Langlois, Peter H AU - Lawson, Christina C AU - Scheuerle, Angela AU - Rocheleau, Carissa M AU - Waters, Martha A AU - Symanski, Elaine AU - Romitti, Paul A AU - Agopian, A J AU - Lupo, Philip J AU - National Birth Defects Prevention Study AD - Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas. ; Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, Texas. ; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. ; Department of Pediatrics, Division of Genetics and Metabolism, University of Texas Southwestern Medical Center, Dallas, Texas. ; Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston, Texas. ; Department of Epidemiology, College of Public Health, University of Iowa, Iowa City. ; Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas. ; National Birth Defects Prevention Study Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 55 EP - 60 VL - 106 IS - 1 KW - Polycyclic Aromatic Hydrocarbons KW - 0 KW - Index Medicus KW - craniosynostosis KW - case-control KW - birth defects KW - polycyclic aromatic hydrocarbon (PAH) KW - Odds Ratio KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Retrospective Studies KW - Infant, Newborn KW - Case-Control Studies KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Pregnancy KW - Maternal Exposure -- adverse effects KW - Craniosynostoses -- epidemiology KW - Occupational Exposure -- adverse effects KW - Polycyclic Aromatic Hydrocarbons -- adverse effects KW - Craniosynostoses -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760880012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Maternal+occupational+exposure+to+polycyclic+aromatic+hydrocarbons+and+craniosynostosis+among+offspring+in+the+National+Birth+Defects+Prevention+Study.&rft.au=O%27Brien%2C+Jacqueline+L%3BLanglois%2C+Peter+H%3BLawson%2C+Christina+C%3BScheuerle%2C+Angela%3BRocheleau%2C+Carissa+M%3BWaters%2C+Martha+A%3BSymanski%2C+Elaine%3BRomitti%2C+Paul+A%3BAgopian%2C+A+J%3BLupo%2C+Philip+J%3BNational+Birth+Defects+Prevention+Study&rft.aulast=O%27Brien&rft.aufirst=Jacqueline&rft.date=2016-01-01&rft.volume=106&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23389 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-11 N1 - Date created - 2016-01-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2004 Apr 15;196(2):191-205 [15081266] Ann Occup Hyg. 2003 Jul;47(5):349-78 [12855487] Cancer Res. 1986 Jan;46(1):94-8 [3753553] Environ Health Perspect. 2006 Nov;114(11):1744-50 [17107862] Birth Defects Res A Clin Mol Teratol. 2008 Feb;82(2):78-85 [18050313] Am J Med Genet A. 2008 Apr 15;146A(8):984-91 [18344207] Environ Health Perspect. 2008 May;116(5):658-65 [18470316] Int J Hyg Environ Health. 2008 Oct;211(5-6):639-47 [18308633] Ann Occup Hyg. 2009 Oct;53(7):723-9 [19759173] Birth Defects Res C Embryo Today. 2010 Jun;90(2):103-9 [20544694] Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12770-5 [21768370] Hum Reprod Update. 2011 Sep-Oct;17(5):589-604 [21747128] J Occup Environ Hyg. 2011 Dec;8(12):718-28 [22074298] Environ Health Perspect. 2012 Jun;120(6):910-5 [22330681] Birth Defects Res A Clin Mol Teratol. 2012 Sep;94(9):693-700 [22807044] J Craniofac Surg. 2012 Sep;23(5):1245-51 [22976622] Birth Defects Res A Clin Mol Teratol. 2012 Nov;94(11):875-81 [22945317] Clin Radiol. 2013 Mar;68(3):284-92 [22939693] Cleft Palate Craniofac J. 2013 May;50(3):337-46 [23136939] Occup Environ Med. 2014 Aug;71(8):529-35 [24893704] Public Health Rep. 2001;116 Suppl 1:32-40 [11889273] Birth Defects Res A Clin Mol Teratol. 2003 Mar;67(3):193-201 [12797461] Teratology. 1977 Oct;16(2):147-53 [412268] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23389 ER - TY - JOUR T1 - Comparative Efficacy of Monoclonal Antibodies That Bind to Different Epitopes of the 2009 Pandemic H1N1 Influenza Virus Neuraminidase AN - 1758247483; PQ0002453182 AB - Antibodies against the neuraminidase (NA) of influenza virus correlate with resistance against disease, but the effectiveness of antibodies against different NA epitopes has not been compared. In the present study, we evaluated the in vitro and in vivo efficacies of four monoclonal antibodies (MAbs): HF5 and CD6, which are specific to two different epitopes in the NA of 2009 pandemic H1N1 (pH1N1) virus, and 4E9 and 1H5, which are specific to a conserved epitope in the NA of both H1N1 and H5N1 viruses. In the in vitro assays, HF5 and CD6 inhibited virus spread and growth more effectively than 4E9 and 1H5, with HF5 being the most effective inhibitor. When administered prophylactically at 5 mg/kg of body weight, HF5 and CD6 protected similar to 90 to 100% of DBA/2 mice against lethal wild-type pH1N1 virus challenge; however, at a lower dose (1 mg/kg), HF5 protected similar to 90% of mice, whereas CD6 protected only 25% of mice. 4E9 and 1H5 were less effective than HF5 and CD6, as indicated by the partial protection achieved even at doses as high as 15 mg/kg. When administered therapeutically, HF5 protected a greater proportion of mice against lethal pH1N1 challenge than CD6. However, HF5 quickly selected pH1N1 virus escape mutants in both prophylactic and therapeutic treatments, while CD6 did not. Our findings confirm the important role of NA-specific antibodies in immunity to influenza virus and provide insight into the properties of NA antibodies that may serve as good candidates for therapeutics against influenza. IMPORTANCE Neuraminidase (NA) is one of the major surface proteins of influenza virus, serving as an important target for antivirals and therapeutic antibodies. The impact of NA-specific antibodies on NA activity and virus replication is likely to depend on where the antibody binds. Using in vitro assays and the mouse model, we compared the inhibitory/protective efficacy of four mouse monoclonal antibodies (MAbs) that bind to different sites within the 2009 pandemic H1N1 (pH1N1) virus NA. The ability of each MAb to protect mice against lethal pH1N1 infection corresponded to its ability to inhibit NA activity in vitro; however, the MAb that was the most effective inhibitor of NA activity selected pH1N1 escape variants in vivo. One of the tested MAbs, which binds to a conserved region in the NA of pH1N1 virus, inhibited NA activity but did not result in escape variants, highlighting its suitability for development as a therapeutic agent. JF - Journal of Virology AU - Jiang, Lianlian AU - Fantoni, Giovanna AU - Couzens, Laura AU - Gao, Jin AU - Plant, Ewan AU - Ye, Zhiping AU - Eichelberger, Maryna C AU - Wan, Hongquan Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 117 EP - 128 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 90 IS - 1 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Monoclonal antibodies KW - Replication KW - Viruses KW - Animal models KW - Mice KW - Disease resistance KW - Immunity KW - Infection KW - Mutants KW - Influenza KW - CD6 antigen KW - pandemics KW - Influenza virus KW - Body weight KW - Proteins KW - Exo- alpha -sialidase KW - Epitopes KW - V 22410:Animal Diseases KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1758247483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Comparative+Efficacy+of+Monoclonal+Antibodies+That+Bind+to+Different+Epitopes+of+the+2009+Pandemic+H1N1+Influenza+Virus+Neuraminidase&rft.au=Jiang%2C+Lianlian%3BFantoni%2C+Giovanna%3BCouzens%2C+Laura%3BGao%2C+Jin%3BPlant%2C+Ewan%3BYe%2C+Zhiping%3BEichelberger%2C+Maryna+C%3BWan%2C+Hongquan&rft.aulast=Jiang&rft.aufirst=Lianlian&rft.date=2016-01-01&rft.volume=90&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.01756-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Number of references - 39 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Influenza; CD6 antigen; pandemics; Body weight; Replication; Monoclonal antibodies; Animal models; Immunity; Disease resistance; Exo- alpha -sialidase; Infection; Epitopes; Viruses; Proteins; Mice; Mutants; Influenza virus DO - http://dx.doi.org/10.1128/JVI.01756-15 ER - TY - JOUR T1 - Investigations of immunotoxicity and allergic potential induced by topical application of triclosan in mice. AN - 1754524054; 25812624 AB - Triclosan is an antimicrobial chemical commonly used occupationally and by the general public. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of triclosan following dermal exposure using a murine model. Triclosan was not identified to be a sensitizer in the murine local lymph node assay (LLNA) when tested at concentrations ranging from 0.75-3.0%. Following a 28-day exposure, triclosan produced a significant increase in liver weight at concentrations of ≥ 1.5%. Exposure to the high dose (3.0%) also produced a significant increase in spleen weights and number of platelets. The absolute number of B-cells, T-cells, dendritic cells and NK cells were significantly increased in the skin draining lymph node, but not the spleen. An increase in the frequency of dendritic cells was also observed in the lymph node following exposure to 3.0% triclosan. The IgM antibody response to sheep red blood cells (SRBC) was significantly increased at 0.75% - but not at the higher concentrations - in the spleen and serum. These results demonstrate that dermal exposure to triclosan induces stimulation of the immune system in a murine model and raise concerns about potential human exposure. JF - Journal of immunotoxicology AU - Anderson, Stacey E AU - Meade, B Jean AU - Long, Carrie M AU - Lukomska, Ewa AU - Marshall, Nikki B AD - a National Institute for Occupational Safety and Health (NIOSH) , Morgantown , WV , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 165 EP - 172 VL - 13 IS - 2 KW - Immunoglobulin M KW - 0 KW - Triclosan KW - 4NM5039Y5X KW - Index Medicus KW - Hypersensitivity KW - triclosan KW - immunotoxicity KW - immune suppression KW - Animals KW - Humans KW - Immunoglobulin M -- immunology KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Administration, Topical KW - Dendritic Cells -- pathology KW - Dendritic Cells -- immunology KW - B-Lymphocytes -- pathology KW - Triclosan -- pharmacology KW - Spleen -- pathology KW - Spleen -- immunology KW - B-Lymphocytes -- immunology KW - T-Lymphocytes -- pathology KW - Triclosan -- adverse effects KW - T-Lymphocytes -- immunology KW - Killer Cells, Natural -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1754524054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Investigations+of+immunotoxicity+and+allergic+potential+induced+by+topical+application+of+triclosan+in+mice.&rft.au=Anderson%2C+Stacey+E%3BMeade%2C+B+Jean%3BLong%2C+Carrie+M%3BLukomska%2C+Ewa%3BMarshall%2C+Nikki+B&rft.aulast=Anderson&rft.aufirst=Stacey&rft.date=2016-01-01&rft.volume=13&rft.issue=2&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.3109%2F1547691X.2015.1029146 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-30 N1 - Date created - 2016-01-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Crit Rev Toxicol. 2010 May;40(5):422-84 [20377306] Toxicol Sci. 2009 Jan;107(1):56-64 [18940961] Environ Toxicol Chem. 2010 Dec;29(12):2840-4 [20954233] Environ Health Perspect. 2011 Mar;119(3):390-6 [21062687] Contact Dermatitis. 2011 Oct;65(4):239-40 [21906072] Toxicology. 2012 Oct 9;300(1-2):31-45 [22659317] J Allergy Clin Immunol. 2012 Aug;130(2):453-60.e7 [22704536] Allergy. 2013 Jan;68(1):84-91 [23146048] Toxicol Sci. 2013 Mar;132(1):96-106 [23192912] Ann Allergy Asthma Immunol. 2014 Feb;112(2):179-181.e2 [24468262] J Immunotoxicol. 2013 Jul-Sep;10(3):223-34 [22954466] J Immunotoxicol. 2013 Jan-Mar;10(1):59-66 [22953780] Environ Sci Technol. 2014 Apr 1;48(7):3603-11 [24588513] Crit Rev Toxicol. 2014 Jul;44(6):535-55 [24897554] Epidemiology. 2014 Sep;25(5):625-35 [25061923] Environ Sci Technol. 2014;48(15):8831-8 [24971846] J Occup Environ Med. 2014 Aug;56(8):834-9 [25099409] Environ Toxicol. 2015 Jan;30(1):83-91 [23929691] Reprod Toxicol. 2015 Jul;54:120-8 [25463527] Environ Toxicol. 2016 May;31(5):609-23 [25410937] Food Chem Toxicol. 2000 Apr;38(4):361-70 [10722890] Am J Infect Control. 2000 Apr;28(2):184-96 [10760227] Toxicology. 2000 May 5;146(2-3):221-7 [10814854] Mar Environ Res. 2000 Jul-Dec;50(1-5):153-6 [11460682] Toxicology. 2002 Jan 15;170(1-2):119-29 [11750089] Chemosphere. 2002 Mar;46(9-10):1485-9 [12002480] Environ Sci Technol. 2002 Jun 1;36(11):2322-9 [12075785] Arch Dermatol. 2002 Aug;138(8):1082-6 [12164747] IMS Ind Med Surg. 1969 Feb;38(2):64-71 [5250173] Toxicology. 1975 Jan;3(1):33-47 [1121705] Contact Dermatitis. 1975 Aug;1(4):231-9 [1235254] Contact Dermatitis. 1988 Apr;18(4):243-4 [3378435] Am J Dent. 1989 Sep;2 Spec No:185-96 [2638179] Arch Environ Contam Toxicol. 1992 Jul;23(1):91-8 [1637203] Toxicol Lett. 1992 Dec;64-65 Spec No:71-8 [1471226] J Toxicol Environ Health A. 2006 Oct;69(20):1861-73 [16952905] J Am Dent Assoc. 2006 Dec;137(12):1649-57 [17138709] Surg Infect (Larchmt). 2007 Apr;8(2):201-8 [17437365] J Appl Toxicol. 2008 Jan;28(1):78-91 [17992702] Environ Health Perspect. 2008 Mar;116(3):303-7 [18335095] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2010 Jul;28(3):147-71 [20859822] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/1547691X.2015.1029146 ER - TY - JOUR T1 - Fine mapping of chromosome 5p15.33 based on a targeted deep sequencing and high density genotyping identifies novel lung cancer susceptibility loci. AN - 1754521549; 26590902 AB - Chromosome 5p15.33 has been identified as a lung cancer susceptibility locus, however the underlying causal mechanisms were not fully elucidated. Previous fine-mapping studies of this locus have relied on imputation or investigated a small number of known, common variants. This study represents a significant advance over previous research by investigating a large number of novel, rare variants, as well as their underlying mechanisms through telomere length. Variants for this fine-mapping study were identified through a targeted deep sequencing (average depth of coverage greater than 4000×) of 576 individuals. Subsequently, 4652 SNPs, including 1108 novel SNPs, were genotyped in 5164 cases and 5716 controls of European ancestry. After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)). In addition, we found that rs139852726 (P = 1.44×10(-3)) was associated with telomere length in a sample of 922 healthy individuals. The gene-based SKAT-O analysis implicated TERT as the most relevant gene in the 5p15.33 region for adenocarcinoma (P = 7.84×10(-7)) and lung cancer (P = 2.37×10(-5)) risk. In this largest fine-mapping study to investigate a large number of rare and novel variants within 5p15.33, we identified novel lung and adenocarcinoma susceptibility loci with large effects and provided support for the role of telomere length as the potential underlying mechanism. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Carcinogenesis AU - Kachuri, Linda AU - Amos, Christopher I AU - McKay, James D AU - Johansson, Mattias AU - Vineis, Paolo AU - Bueno-de-Mesquita, H Bas AU - Boutron-Ruault, Marie-Christine AU - Johansson, Mikael AU - Quirós, J Ramón AU - Sieri, Sabina AU - Travis, Ruth C AU - Weiderpass, Elisabete AU - Le Marchand, Loic AU - Henderson, Brian E AU - Wilkens, Lynne AU - Goodman, Gary E AU - Chen, Chu AU - Doherty, Jennifer A AU - Christiani, David C AU - Wei, Yongyue AU - Su, Li AU - Tworoger, Shelley AU - Zhang, Xuehong AU - Kraft, Peter AU - Zaridze, David AU - Field, John K AU - Marcus, Michael W AU - Davies, Michael P A AU - Hyde, Russell AU - Caporaso, Neil E AU - Landi, Maria Teresa AU - Severi, Gianluca AU - Giles, Graham G AU - Liu, Geoffrey AU - McLaughlin, John R AU - Li, Yafang AU - Xiao, Xiangjun AU - Fehringer, Gord AU - Zong, Xuchen AU - Denroche, Robert E AU - Zuzarte, Philip C AU - McPherson, John D AU - Brennan, Paul AU - Hung, Rayjean J AD - Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada, Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada. ; Department of Community and Family Medicine, Center for Genomic Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03766, USA. ; International Agency for Research on Cancer, Lyon, CEDEX 08, 69372, France. ; Human Genetics Foundation (HuGeF), 10126 Torino, Italy, Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK. ; Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), 3721 MA Bilthoven, The Netherlands, Department of Gastroenterology and Hepatology, University Medical Centre, 3584 CX Utrecht, The Netherlands, Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London SW7 2AZ, UK, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia. ; INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018, Lifestyle, Genes and Health: Integrative Trans-Generational Epidemiology, 94805 Villejuif, France, Université Paris Sud, UMRS 1018 94805, Villejuif, France, Institut Gustave Roussy F-94805, Villejuif, France. ; Department of Radiation Sciences, Umeå University, Umeå SE-901 87, Sweden. ; Public Health Directorate Asturias, CP 33006 Oviedo, Spain. ; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milano, Italy. ; Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK. ; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, 9037 Tromsø, Norway, Department of Research, Cancer Registry of Norway, 0379 Oslo, Norway, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm SE-171 77, Sweden, Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki FI-00014, Finland. ; University of Hawaii Cancer Center, Honolulu, HI 96813, USA. ; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. ; Departments of Environmental Health and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. ; Departments of Environmental Health and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. ; Departments of Environmental Health and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. ; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. ; Departments of Biostatistics and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. ; Russian Cancer Research Center, Moscow 115478, Russia. ; Roy Castle Lung Cancer Research Programme, University of Liverpool Cancer Research Centre Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. ; Human Genetics Foundation (HuGeF), 10126 Torino, Italy, INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018, Lifestyle, Genes and Health: Integrative Trans-Generational Epidemiology, 94805 Villejuif, France, Université Paris Sud, UMRS 1018 94805, Villejuif, France, Institut Gustave Roussy F-94805, Villejuif, France, Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne 3004, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne 3010, Australia. ; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne 3004, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne 3010, Australia, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne 3004, Australia. ; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada, Ontario Cancer Institute, Princess Margaret Cancer Center, Toronto, Ontario M5G 0A3, Canada. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada, Public Health Ontario, Toronto, Ontario M5G 1V2, Canada, and. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada. ; Genome Technologies, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada, Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario M5T 3M7, Canada, rayjean.hung@lunenfeld.ca. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 96 EP - 105 VL - 37 IS - 1 KW - Index Medicus KW - Humans KW - Case-Control Studies KW - Middle Aged KW - Genetic Predisposition to Disease KW - Chromosome Mapping -- methods KW - Genotyping Techniques -- methods KW - Male KW - Female KW - Genetic Loci KW - Lung Neoplasms -- genetics KW - Chromosomes, Human, Pair 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1754521549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Fine+mapping+of+chromosome+5p15.33+based+on+a+targeted+deep+sequencing+and+high+density+genotyping+identifies+novel+lung+cancer+susceptibility+loci.&rft.au=Kachuri%2C+Linda%3BAmos%2C+Christopher+I%3BMcKay%2C+James+D%3BJohansson%2C+Mattias%3BVineis%2C+Paolo%3BBueno-de-Mesquita%2C+H+Bas%3BBoutron-Ruault%2C+Marie-Christine%3BJohansson%2C+Mikael%3BQuir%C3%B3s%2C+J+Ram%C3%B3n%3BSieri%2C+Sabina%3BTravis%2C+Ruth+C%3BWeiderpass%2C+Elisabete%3BLe+Marchand%2C+Loic%3BHenderson%2C+Brian+E%3BWilkens%2C+Lynne%3BGoodman%2C+Gary+E%3BChen%2C+Chu%3BDoherty%2C+Jennifer+A%3BChristiani%2C+David+C%3BWei%2C+Yongyue%3BSu%2C+Li%3BTworoger%2C+Shelley%3BZhang%2C+Xuehong%3BKraft%2C+Peter%3BZaridze%2C+David%3BField%2C+John+K%3BMarcus%2C+Michael+W%3BDavies%2C+Michael+P+A%3BHyde%2C+Russell%3BCaporaso%2C+Neil+E%3BLandi%2C+Maria+Teresa%3BSeveri%2C+Gianluca%3BGiles%2C+Graham+G%3BLiu%2C+Geoffrey%3BMcLaughlin%2C+John+R%3BLi%2C+Yafang%3BXiao%2C+Xiangjun%3BFehringer%2C+Gord%3BZong%2C+Xuchen%3BDenroche%2C+Robert+E%3BZuzarte%2C+Philip+C%3BMcPherson%2C+John+D%3BBrennan%2C+Paul%3BHung%2C+Rayjean+J&rft.aulast=Kachuri&rft.aufirst=Linda&rft.date=2016-01-01&rft.volume=37&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgv165 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-15 N1 - Date created - 2016-01-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Genetics. 2000 Jun;155(2):945-59 [10835412] Lancet Oncol. 2011 Apr;12(4):399-408 [20951091] Nucleic Acids Res. 2002 May 15;30(10):e47 [12000852] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Mutagenesis. 2002 Nov;17(6):539-50 [12435851] Br J Cancer. 2004 Mar 22;90(6):1222-9 [15026805] Science. 1998 Jan 16;279(5349):349-52 [9454332] Hum Mutat. 2005 Oct;26(4):343-50 [16110488] J Clin Oncol. 2006 May 20;24(15):2245-51 [16710022] Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11724-9 [16864775] Int J Cancer. 2007 May 1;120(9):1835-41 [17311257] Hum Mol Genet. 2007 Aug 1;16(15):1794-801 [17517688] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] Nat Rev Cancer. 2007 Oct;7(10):778-90 [17882278] Genet Epidemiol. 2008 May;32(4):361-9 [18271029] Curr Biol. 2008 Jun 24;18(12):883-9 [18571414] Nat Genet. 2008 Dec;40(12):1407-9 [18978787] Nat Genet. 2008 Dec;40(12):1404-6 [18978790] J Mol Med (Berl). 2009 Jan;87(1):85-97 [18974965] Nat Genet. 2009 Feb;41(2):221-7 [19151717] Am J Hum Genet. 2009 Nov;85(5):679-91 [19836008] Int J Epidemiol. 2009 Dec;38(6):1725-34 [19666704] Nat Genet. 2010 Mar;42(3):224-8 [20101243] BMC Bioinformatics. 2010;11:288 [20509871] J Natl Cancer Inst. 2010 Jul 7;102(13):959-71 [20548021] BMC Cancer. 2010;10:285 [20546590] PLoS Genet. 2010 Aug;6(8). pii: e1001051. doi: 10.1371/journal.pgen.1001051 [20700438] PLoS One. 2010;5(8):e12236 [20808933] Bioinformatics. 2010 Sep 15;26(18):2336-7 [20634204] CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 [21296855] Nat Genet. 2011 Aug;43(8):785-91 [21743467] Carcinogenesis. 2011 Oct;32(10):1493-9 [21771723] Exp Mol Pathol. 2012 Feb;92(1):105-10 [22101258] Nat Genet. 2012 Aug;44(8):900-3 [22797724] Am J Hum Genet. 2012 Aug 10;91(2):224-37 [22863193] Br J Cancer. 2012 Sep 4;107(6):1001-8 [22878375] Hum Mol Genet. 2012 Nov 15;21(22):4980-95 [22899653] Nat Genet. 2012 Dec;44(12):1330-5 [23143601] Curr Protoc Hum Genet. 2013 Jan;Chapter 7:Unit7.20 [23315928] Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):251-60 [23221128] Cancer Res. 2014 Feb 15;74(4):1116-27 [24366883] PLoS One. 2014;9(4):e93455 [24728235] Cancer Res. 2014 May 1;74(9):2476-86 [24618342] Nat Genet. 2014 Jul;46(7):731-5 [24908248] Hum Mol Genet. 2014 Dec 15;23(24):6616-33 [25027329] Eur J Hum Genet. 2015 Dec;23(12):1723-8 [25804397] Biochem Biophys Res Commun. 2001 Feb 2;280(4):1148-54 [11162647] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/carcin/bgv165 ER - TY - JOUR T1 - Occupational Lead Exposure and Associations with Selected Cancers: The Shanghai Men's and Women's Health Study Cohorts. AN - 1754093789; 26091556 AB - Epidemiologic studies of occupational lead exposure have suggested increased risks of cancers of the stomach, lung, kidney, brain, and meninges; however, the totality of the evidence is inconsistent. We investigated the relationship between occupational lead exposure and cancer incidence at the five abovementioned sites in two prospective cohorts in Shanghai, China. Annual job/industry-specific estimates of lead fume and lead dust exposure, derived from a statistical model combining expert lead intensity ratings with inspection measurements, were applied to the lifetime work histories of participants from the Shanghai Women's Health Study (SWHS; n = 73,363) and the Shanghai Men's Health Study (SMHS; n = 61,379) to estimate cumulative exposure to lead fume and lead dust. These metrics were then combined into an overall occupational lead exposure variable. Cohort-specific relative hazard rate ratios (RRs) and 95% confidence intervals (CIs) comparing exposed and unexposed participants were estimated using Cox proportional hazards regression and combined by meta-analysis. The proportions of SWHS and SMHS participants with estimated occupational lead exposure were 8.9% and 6.9%, respectively. Lead exposure was positively associated with meningioma risk in women only (n = 38 unexposed and 9 exposed cases; RR = 2.4; 95% CI: 1.1, 5.0), particularly with above-median cumulative exposure (RR = 3.1; 95% CI: 1.3, 7.4). However, all 12 meningioma cases among men were classified as unexposed to lead. We also observed non-significant associations with lead exposure for cancers of the kidney (n = 157 unexposed and 17 ever exposed cases; RR = 1.4; 95% CI: 0.9, 2.3) and brain (n = 67 unexposed and 10 ever exposed cases; RR = 1.8; 95% CI: 0.7, 4.8) overall. Our findings, though limited by small numbers of cases, suggest that lead is associated with the risk of several cancers in women and men. Liao LM, Friesen MC, Xiang YB, Cai H, Koh DH, Ji BT, Yang G, Li HL, Locke SJ, Rothman N, Zheng W, Gao YT, Shu XO, Purdue MP. 2016. Occupational lead exposure and associations with selected cancers: the Shanghai Men's and Women's Health Study cohorts. Environ Health Perspect 124:97-103; http://dx.doi.org/10.1289/ehp.1408171. JF - Environmental health perspectives AU - Liao, Linda M AU - Friesen, Melissa C AU - Xiang, Yong-Bing AU - Cai, Hui AU - Koh, Dong-Hee AU - Ji, Bu-Tian AU - Yang, Gong AU - Li, Hong-Lan AU - Locke, Sarah J AU - Rothman, Nathaniel AU - Zheng, Wei AU - Gao, Yu-Tang AU - Shu, Xiao-Ou AU - Purdue, Mark P AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 97 EP - 103 VL - 124 IS - 1 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Prospective Studies KW - Meningioma -- epidemiology KW - Humans KW - China -- epidemiology KW - Adult KW - Confidence Intervals KW - Aged KW - Middle Aged KW - Male KW - Female KW - Proportional Hazards Models KW - Lead -- toxicity KW - Occupational Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1754093789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Occupational+Lead+Exposure+and+Associations+with+Selected+Cancers%3A+The+Shanghai+Men%27s+and+Women%27s+Health+Study+Cohorts.&rft.au=Liao%2C+Linda+M%3BFriesen%2C+Melissa+C%3BXiang%2C+Yong-Bing%3BCai%2C+Hui%3BKoh%2C+Dong-Hee%3BJi%2C+Bu-Tian%3BYang%2C+Gong%3BLi%2C+Hong-Lan%3BLocke%2C+Sarah+J%3BRothman%2C+Nathaniel%3BZheng%2C+Wei%3BGao%2C+Yu-Tang%3BShu%2C+Xiao-Ou%3BPurdue%2C+Mark+P&rft.aulast=Liao&rft.aufirst=Linda&rft.date=2016-01-01&rft.volume=124&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408171 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-01-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Expo Sci Environ Epidemiol. 2014 Jan-Feb;24(1):9-16 [22910004] Occup Environ Med. 2013 Mar;70(3):164-70 [23322922] Am J Ind Med. 2000 Sep;38(3):295-9 [10940967] J Occup Environ Med. 2002 Jul;44(7):663-8 [12134530] Environ Health Perspect. 2000 Aug;108(8):719-22 [10964791] Am J Ind Med. 2000 Sep;38(3):330-4 [10940972] Am J Ind Med. 2002 Sep;42(3):214-27 [12210690] Mutat Res. 2003 Dec 10;533(1-2):121-33 [14643416] Mutat Res. 1993 Jan;285(1):117-24 [7678125] Regul Toxicol Pharmacol. 1995 Oct;22(2):162-71 [8577951] J Occup Environ Med. 1996 Feb;38(2):131-6 [8673517] Epidemiol Rev. 1995;17(2):382-414 [8654518] Scand J Work Environ Health. 1995 Dec;21(6):460-9 [8824752] J Occup Environ Med. 1998 Nov;40(11):937-42 [9830598] Am J Ind Med. 1999 Jul;36(1):70-4 [10361589] Am J Epidemiol. 2005 Dec 1;162(11):1123-31 [16236996] Int J Cancer. 2006 Sep 1;119(5):1136-44 [16570286] Cancer Epidemiol Biomarkers Prev. 2006 Dec;15(12):2514-20 [17164378] Environ Res. 2007 May;104(1):85-95 [16996054] Am J Epidemiol. 2007 Nov 1;166(9):1005-14 [17690218] Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1841-8 [19505917] Environ Health Perspect. 2010 Oct;118(10):1355-62 [20562050] J Occup Environ Hyg. 2011 Sep;8(9):520-32 [21793732] PLoS One. 2011;6(7):e20432 [21799727] Occup Environ Med. 2011 Oct;68(10):723-8 [21217163] Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):191-201 [22086884] Occup Environ Med. 2012 Feb;69(2):87-92 [22039095] Ann Epidemiol. 2012 Apr;22(4):270-6 [22285868] Int J Epidemiol. 2015 Jun;44(3):810-8 [25733578] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408171 ER - TY - JOUR T1 - How Can Mutations Thermostabilize G-Protein-Coupled Receptors? AN - 1753230501; 26547284 AB - Structures of over 30 different G-protein-coupled receptors (GPCRs) have advanced our understanding of cell signaling and have provided a foundation for structure-guided drug design. This exciting progress has required the development of three complementary methods to facilitate GPCR crystallization, one of which is the thermostabilization of receptors by systematic mutagenesis. However, the reason why a particular mutation, or combination of mutations, stabilizes the receptor is not always evident from a static crystal structure. Molecular dynamics (MD) simulations have been used to identify and estimate the energetic factors that affect thermostability through comparing the dynamics of the thermostabilized receptors with structure-based models of the wild-type receptor. The data indicate that receptors are stabilized through a combination of factors, including an increase in receptor rigidity, a decrease in collective motion, reduced stress at specific residues, and the presence of ordered water molecules. Predicting thermostabilizing mutations computationally represents a major challenge for the field. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Trends in pharmacological sciences AU - Vaidehi, Nagarajan AU - Grisshammer, Reinhard AU - Tate, Christopher G AD - Division of Immunology, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address: NVaidehi@coh.org. ; Membrane Protein Structure Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NIH), Department of Health and Human Services, Rockville, MD 20852, USA. ; Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Avenue, Cambridge CB2 0QH, UK. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 37 EP - 46 VL - 37 IS - 1 KW - Receptors, G-Protein-Coupled KW - 0 KW - Index Medicus KW - structure KW - dynamics KW - thermostability KW - GPCR KW - Heating KW - Protein Stability KW - Humans KW - Molecular Dynamics Simulation KW - Structure-Activity Relationship KW - Protein Conformation KW - Receptors, G-Protein-Coupled -- chemistry KW - Receptors, G-Protein-Coupled -- metabolism KW - Receptors, G-Protein-Coupled -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753230501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+pharmacological+sciences&rft.atitle=How+Can+Mutations+Thermostabilize+G-Protein-Coupled+Receptors%3F&rft.au=Vaidehi%2C+Nagarajan%3BGrisshammer%2C+Reinhard%3BTate%2C+Christopher+G&rft.aulast=Vaidehi&rft.aufirst=Nagarajan&rft.date=2016-01-01&rft.volume=37&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Trends+in+pharmacological+sciences&rft.issn=1873-3735&rft_id=info:doi/10.1016%2Fj.tips.2015.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-27 N1 - Date created - 2016-01-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nature. 2011 Jun 23;474(7352):521-5 [21593763] Science. 2013 Sep 20;341(6152):1387-90 [24030490] Structure. 2011 Sep 7;19(9):1283-93 [21885291] Nature. 2011 Sep 29;477(7366):549-55 [21772288] Chem Rev. 2006 May;106(5):1616-23 [16683747] J Mol Biol. 2007 Oct 5;372(5):1179-88 [17825322] Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15682-7 [17905872] Science. 2007 Nov 23;318(5854):1266-73 [17962519] Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):877-82 [18192400] Biophys J. 2008 Mar 15;94(6):2027-42 [18065472] J Mol Biol. 2008 Aug 29;381(2):478-86 [18585736] Nature. 2008 Jul 24;454(7203):486-91 [18594507] J Mol Biol. 2008 Oct 3;382(2):539-55 [18638482] Nature. 2009 May 21;459(7245):356-63 [19458711] Proc Natl Acad Sci U S A. 2009 May 26;106(21):8555-60 [19433801] J Mol Biol. 2009 Jul 10;390(2):262-77 [19422831] Curr Opin Struct Biol. 2009 Aug;19(4):386-95 [19682887] Mol Membr Biol. 2009 Dec;26(8):385-96 [19883298] Biophys J. 2010 Jul 21;99(2):568-77 [20643076] Neuropharmacology. 2011 Jan;60(1):36-44 [20624408] Nature. 2011 Jan 13;469(7329):241-4 [21228877] Proc Natl Acad Sci U S A. 2011 May 17;108(20):8228-32 [21540331] J Mol Biol. 2011 Jun 10;409(3):298-310 [21501622] J Mol Biol. 2011 Oct 28;413(3):628-38 [21907721] J Med Chem. 2012 Mar 8;55(5):1898-903 [22220592] J Med Chem. 2012 Mar 8;55(5):1904-9 [22250781] J Am Chem Soc. 2010 Apr 14;132(14):5205-14 [20235532] Trends Pharmacol Sci. 2012 May;33(5):249-60 [22465153] Structure. 2012 May 9;20(5):841-9 [22579251] Structure. 2012 Jun 6;20(6):967-76 [22681902] Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13284-9 [22847407] Trends Biochem Sci. 2012 Sep;37(9):343-52 [22784935] Nature. 2012 Oct 25;490(7421):508-13 [23051748] Trends Pharmacol Sci. 2013 Jan;34(1):67-84 [23245528] Annu Rev Pharmacol Toxicol. 2013;53:531-56 [23140243] Nature. 2013 Oct 24;502(7472):575-9 [24056936] Nature. 2013 Nov 7;503(7474):85-90 [24037379] Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):E655-62 [24453215] Science. 2014 Feb 14;343(6172):795-8 [24531972] Biochim Biophys Acta. 2014 May;1837(5):606-13 [24055285] J Phys Chem B. 2014 Mar 27;118(12):3355-65 [24579769] Biophys J. 2014 Jul 15;107(2):422-34 [25028884] Nature. 2014 Jul 31;511(7511):557-62 [25042998] Science. 2014 Aug 29;345(6200):1021-6 [25103405] Nature. 2014 Sep 4;513(7516):124-7 [25043059] Nat Commun. 2014;5:4733 [25203160] J Phys Chem B. 2015 Apr 16;119(15):4917-28 [25807267] Nat Commun. 2015;6:7895 [26205105] Cell. 2013 Jan 31;152(3):532-42 [23374348] Nature. 2013 Feb 14;494(7436):185-94 [23407534] Biochim Biophys Acta. 2013 Apr;1828(4):1293-301 [23337476] J Med Chem. 2013 May 9;56(9):3446-55 [23517028] J Phys Chem B. 2013 Jun 20;117(24):7283-91 [23697892] Nature. 2013 Jul 25;499(7459):438-43 [23863939] Curr Opin Struct Biol. 2011 Aug;21(4):567-72 [21782416] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tips.2015.09.005 ER - TY - BOOK T1 - NIEHS Celebrates 50 Years of Environmental Health Research at the NIH. AN - 1753010968; 26719977 JF - Environmental health perspectives AU - Birnbaum, Linda S Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 1 EP - A5 KW - Index Medicus KW - United States KW - History, 21st Century KW - History, 20th Century KW - Humans KW - National Institute of Environmental Health Sciences (U.S.) KW - Research -- organization & administration KW - Research -- history KW - Environmental Health -- organization & administration KW - Environmental Health -- history UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753010968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/TOXLINE&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=unknown&rft.jtitle=&rft.atitle=&rft.au=Birnbaum%2C+Linda+S&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2016-01-01&rft.volume=&rft.issue=&rft.spage=A5&rft.isbn=&rft.btitle=NIEHS+Celebrates+50+Years+of+Environmental+Health+Research+at+the+NIH.&rft.title=NIEHS+Celebrates+50+Years+of+Environmental+Health+Research+at+the+NIH.&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1511015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-12-13 N1 - Date created - 2016-01-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1511015 ER - TY - JOUR T1 - White matter structure alterations in HIV-1-infected men with sustained suppression of viraemia on treatment. AN - 1751486305; 26691551 AB - Cognitive impairment is highly prevalent in HIV-1-infected (HIV+) patients, despite adequate suppression of viral replication by combination antiretroviral therapy (cART). Cerebral white matter structure alterations are often associated with cognitive impairment and have commonly been reported in the natural course of HIV infection. However, the existence of these alterations in adequately treated HIV+ patients remains unknown, as well as its possible association with cognitive impairment. We used diffusion tensor imaging (DTI) to investigate whether white matter structure alterations exist in HIV+ patients with sustained suppressed viral replication on cART, and if such alterations are related to HIV-associated cognitive deficits. We compared 100 aviraemic HIV+ men on cART with 70 HIV-uninfected, otherwise comparable men. Clinical and neuropsychological assessments were performed. From DTI data, white matter fractional anisotropy and mean diffusion were calculated. Subsequently, tract-based spatial statistics (TBSS) was performed, with and without masking out white matter lesions. HIV+ patients showed diffuse white matter structure alterations as compared with HIV-uninfected controls, observed as widespread decreased fractional anisotropy and an increased mean diffusion. These white matter structure alterations were associated with the number of years spent with a CD4 cell count below 500 cells/μl, but not with HIV-associated cognitive deficits. Cerebral white matter structure alterations are found in middle-aged HIV+ men with sustained suppression of viraemia on cART, and may result from periods with immune deficiency when viral toxicity and host-inflammatory responses were at their peak. These white matter structure alterations were not associated with the observed subtle HIV-associated cognitive deficits. . JF - AIDS (London, England) AU - Su, Tanja AU - Caan, Matthan W A AU - Wit, Ferdinand W N M AU - Schouten, Judith AU - Geurtsen, Gert J AU - Cole, James H AU - Sharp, David J AU - Vos, Frans M AU - Prins, Maria AU - Portegies, Peter AU - Reiss, Peter AU - Majoie, Charles B AU - AGEhIV Cohort Study AD - aDepartment of Radiology, Academic Medical CenterbDepartment of Global Health, Academic Medical Center, and Amsterdam Institute for Global Health and Development (AIGHD)cDepartment of Internal Medicine, Division of Infectious Diseases, Center for Infection and Immunity Amsterdam (CINIMA)dDepartment of Neurology, Academic Medical Center, Amsterdam, the NetherlandseThe Computational, Cognitive, and Clinical Neuroimaging Laboratory, Department of Medicine, Imperial College London, London, United KingdomfQuantitative Imaging Group, Delft University of Technology, DelftgCluster Infectious Diseases Research, Public Health Service of AmsterdamhDepartment of Neurology, OnzeLieveVrouweGasthuis (OLVG Hospital)iHIV Monitoring Foundation, Amsterdam, The Netherlands. ; AGEhIV Cohort Study Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 311 EP - 322 VL - 30 IS - 2 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Diffusion Tensor Imaging KW - Humans KW - AIDS Dementia Complex -- epidemiology KW - Middle Aged KW - Male KW - Leukoencephalopathies -- pathology KW - Leukoencephalopathies -- complications KW - HIV Infections -- virology KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- complications KW - White Matter -- pathology KW - HIV-1 -- isolation & purification KW - HIV Infections -- drug therapy KW - Leukoencephalopathies -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751486305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=White+matter+structure+alterations+in+HIV-1-infected+men+with+sustained+suppression+of+viraemia+on+treatment.&rft.au=Su%2C+Tanja%3BCaan%2C+Matthan+W+A%3BWit%2C+Ferdinand+W+N+M%3BSchouten%2C+Judith%3BGeurtsen%2C+Gert+J%3BCole%2C+James+H%3BSharp%2C+David+J%3BVos%2C+Frans+M%3BPrins%2C+Maria%3BPortegies%2C+Peter%3BReiss%2C+Peter%3BMajoie%2C+Charles+B%3BAGEhIV+Cohort+Study&rft.aulast=Su&rft.aufirst=Tanja&rft.date=2016-01-01&rft.volume=30&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=1473-5571&rft_id=info:doi/10.1097%2FQAD.0000000000000945 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-10-06 N1 - Date created - 2015-12-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/QAD.0000000000000945 ER - TY - JOUR T1 - mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice. AN - 1738816129; 25926378 AB - Inhalation exposure to multi-walled carbon nanotubes (MWCNT) in mice results in inflammation, fibrosis and the promotion of lung adenocarcinoma; however, the molecular basis behind these pathologies is unknown. This study determined global mRNA and miRNA profiles in whole blood from mice exposed by inhalation to MWCNT that correlated with the presence of lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma. Six-week-old, male, B6C3F1 mice received a single intraperitoneal injection of either the DNA-damaging agent methylcholanthrene (MCA, 10 µg g(-1) body weight) or vehicle (corn oil). One week after injections, mice were exposed by inhalation to MWCNT (5 mg m(-3), 5 hours per day, 5 days per week) or filtered air (control) for a total of 15 days. At 17 months post-exposure, mice were euthanized and examined for the development of pathological changes in the lung, and whole blood was collected and analyzed using microarray analysis for global mRNA and miRNA expression. Numerous mRNAs and miRNAs in the blood were significantly up- or down-regulated in animals developing pathological changes in the lung after MCA/corn oil administration followed by MWCNT/air inhalation, including fcrl5 and miR-122-5p in the presence of hyperplasia, mthfd2 and miR-206-3p in the presence of fibrosis, fam178a and miR-130a-3p in the presence of bronchiolo-alveolar adenoma, and il7r and miR-210-3p in the presence of bronchiolo-alveolar adenocarcinoma, among others. The changes in miRNA and mRNA expression, and their respective regulatory networks, identified in this study may potentially serve as blood biomarkers for MWCNT-induced lung pathological changes. Copyright © 2015 John Wiley & Sons, Ltd. JF - Journal of applied toxicology : JAT AU - Snyder-Talkington, Brandi N AU - Dong, Chunlin AU - Sargent, Linda M AU - Porter, Dale W AU - Staska, Lauren M AU - Hubbs, Ann F AU - Raese, Rebecca AU - McKinney, Walter AU - Chen, Bean T AU - Battelli, Lori AU - Lowry, David T AU - Reynolds, Steven H AU - Castranova, Vincent AU - Qian, Yong AU - Guo, Nancy L AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA. ; Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV, 26506-9300, USA. ; WIL Research, Hillsborough, NC, 27278, USA. ; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV, 26506, USA. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 161 EP - 174 VL - 36 IS - 1 KW - MicroRNAs KW - 0 KW - Nanotubes, Carbon KW - RNA, Messenger KW - Index Medicus KW - adenocarcinoma KW - miRNA KW - fibrosis KW - MCA KW - MWCNT KW - mRNA KW - Animals KW - Hyperplasia KW - Inhalation Exposure KW - Gene Regulatory Networks KW - Mice KW - Male KW - Lung Neoplasms -- etiology KW - RNA, Messenger -- blood KW - Adenocarcinoma -- etiology KW - MicroRNAs -- blood KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Lung -- pathology KW - Adenoma -- genetics KW - Nanotubes, Carbon -- toxicity KW - Pulmonary Fibrosis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738816129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=mRNAs+and+miRNAs+in+whole+blood+associated+with+lung+hyperplasia%2C+fibrosis%2C+and+bronchiolo-alveolar+adenoma+and+adenocarcinoma+after+multi-walled+carbon+nanotube+inhalation+exposure+in+mice.&rft.au=Snyder-Talkington%2C+Brandi+N%3BDong%2C+Chunlin%3BSargent%2C+Linda+M%3BPorter%2C+Dale+W%3BStaska%2C+Lauren+M%3BHubbs%2C+Ann+F%3BRaese%2C+Rebecca%3BMcKinney%2C+Walter%3BChen%2C+Bean+T%3BBattelli%2C+Lori%3BLowry%2C+David+T%3BReynolds%2C+Steven+H%3BCastranova%2C+Vincent%3BQian%2C+Yong%3BGuo%2C+Nancy+L&rft.aulast=Snyder-Talkington&rft.aufirst=Brandi&rft.date=2016-01-01&rft.volume=36&rft.issue=1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3157 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-26 N1 - Date created - 2015-12-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Clin Cancer Res. 2013 Aug 15;19(16):4315-25 [23780890] Toxicol Appl Pharmacol. 2013 Oct 15;272(2):476-89 [23845593] Biochim Biophys Acta. 2013 Nov;1834(11):2242-58 [23376433] Nanotoxicology. 2013 Nov;7(7):1179-94 [22881873] Regul Toxicol Pharmacol. 2014 Feb;68(1):108-18 [24287155] Part Fibre Toxicol. 2014;11:3 [24405760] Part Fibre Toxicol. 2014;11:6 [24479647] Part Fibre Toxicol. 2014;11:28 [24915862] Chest. 2014 Jul;146(1):193-204 [25010962] Cancer Res. 2005 Nov 1;65(21):9628-32 [16266980] J Biol Chem. 2006 Mar 10;281(10):6442-7 [16407199] J Pharmacol Exp Ther. 2007 Apr;321(1):409-19 [17251392] Proc Am Thorac Soc. 2008 Apr 15;5(3):305-10 [18403324] Part Fibre Toxicol. 2013;10:38 [23927530] Part Fibre Toxicol. 2013;10:33 [23895460] Respir Res. 2014;15:127 [25306249] Am J Physiol Lung Cell Mol Physiol. 2014 Nov 1;307(9):L681-91 [25260757] Respir Med. 2014 Oct;108(10):1549-55 [25175479] Toxicology. 2015 Feb 3;328:66-74 [25511174] Toxicol Pathol. 2015 Jan;43(1):107-14 [25351923] Toxicol Sci. 2015 Mar;144(1):51-64 [25527334] Part Fibre Toxicol. 2014;11:59 [25410479] Eur Respir J. 2010 Mar;35(3):496-504 [20190329] Toxicology. 2010 Mar 10;269(2-3):136-47 [19857541] Mol Cancer. 2010;9:134 [20515486] Am J Respir Crit Care Med. 2010 Jul 15;182(2):220-9 [20395557] Annu Rev Pharmacol Toxicol. 2011;51:25-43 [20809797] Biochem Biophys Res Commun. 2011 Feb 11;405(2):153-6 [21232526] Cell Death Differ. 2011 Mar;18(3):465-78 [20885442] Am J Respir Crit Care Med. 2011 Feb 15;183(4):431-40 [20935110] Transl Res. 2011 Apr;157(4):191-9 [21420029] J Occup Environ Med. 2011 Jun;53(6 Suppl):S14-7 [21606847] PLoS One. 2011;6(6):e21253 [21712985] J Immunol. 2011 Sep 15;187(6):2875-84 [21844389] Nat Med. 2000 Jun;6(6):659-66 [10835682] Altern Lab Anim. 1995 May-Jun;23(3):298-304 [11656565] J Biol Chem. 2001 Nov 9;276(45):42364-9 [11546821] Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1978-83 [11830638] Front Biosci. 2002 Apr 1;7:d793-807 [11897555] Oncogene. 2002 May 16;21(22):3579-91 [12032860] Cytokine Growth Factor Rev. 2002 Aug-Oct;13(4-5):413-21 [12220554] EMBO J. 2002 Sep 16;21(18):4885-95 [12234928] Breast Cancer Res Treat. 2002 Sep;75(1):25-34 [12500932] Biostatistics. 2003 Apr;4(2):249-64 [12925520] Cell. 1993 Dec 3;75(5):843-54 [8252621] Cancer Detect Prev. 1993;17(6):567-73 [8275509] Cancer Res. 1997 Jul 15;57(14):2832-4 [9230183] Oncogene. 1999 Jan 7;18(1):1-8 [9926914] J Clin Invest. 1999 Jul;104(1):5-11 [10393693] Blood. 1999 Aug 1;94(3):984-93 [10419890] Oncogene. 2005 May 12;24(21):3397-408 [15735721] Lung Cancer. 2005 Jul;49(1):1-12 [15949585] Nature. 2008 Sep 4;455(7209):58-63 [18668040] Am J Pathol. 2009 May;174(5):1629-37 [19342368] Cancer Res. 2009 Jul 1;69(13):5553-9 [19549910] Cancer Res. 2009 Jul 15;69(14):5776-83 [19584273] Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12085-90 [19597153] Mol Cell Biol. 2009 Sep;29(17):4612-22 [19564417] J Biol Chem. 2009 Aug 28;284(35):23217-24 [19570985] Inhal Toxicol. 2009 Oct;21(12):1053-61 [19555230] Oncogene. 2011 Sep 8;30(36):3875-86 [21460851] Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1330-8 [22084097] Proc Natl Acad Sci U S A. 2012 May 1;109(18):7031-6 [22509024] Swiss Med Wkly. 2012;142:w13547 [22714122] J Toxicol Environ Health A. 2012;75(18):1129-53 [22891886] Cell. 2012 Sep 14;150(6):1107-20 [22980975] J Immunol. 2012 Nov 15;189(10):4759-69 [23053511] PLoS One. 2013;8(1):e53573 [23301086] Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):612-7 [23267098] Future Oncol. 2013 Mar;9(3):387-402 [23469974] Toxicol Sci. 2013 May;133(1):79-89 [23377615] J Biol Chem. 2013 Jun 14;288(24):17532-43 [23629655] Part Fibre Toxicol. 2013;10:35 [23903001] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3157 ER - TY - JOUR T1 - Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation. AN - 1736680921; 26497278 AB - α1-Microglobulin (A1M) is a reductase and radical scavenger involved in physiological protection against oxidative damage. These functions were previously shown to be dependent upon cysteinyl-, C34, and lysyl side-chains, K(92, 118,130). A1M binds heme and the crystal structure suggests that C34 and H123 participate in a heme binding site. We have investigated the involvement of these five residues in the interactions with heme. Four A1M-variants were expressed: with cysteine to serine substitution in position 34, lysine to threonine substitutions in positions (92, 118, 130), histidine to serine substitution in position 123 and a wt without mutations. Heme binding was investigated by tryptophan fluorescence quenching, UV-Vis spectrophotometry, circular dichroism, SPR, electrophoretic migration shift, gel filtration, catalase-like activity and molecular simulation. All A1M-variants bound to heme. Mutations in C34, H123 or K(92, 118, 130) resulted in significant absorbance changes, CD spectral changes, and catalase-like activity, suggesting involvement of these side-groups in coordination of the heme-iron. Molecular simulation support a model with two heme-binding sites in A1M involving the mutated residues. Binding of the first heme induces allosteric stabilization of the structure predisposing for a better fit of the second heme. The results suggest that one heme-binding site is located in the lipocalin pocket and a second binding site between loops 1 and 4. Reactions with the hemes involve the side-groups of C34, K(92, 118, 130) and H123. The model provides a structural basis for the functional activities of A1M: heme binding activity of A1M. Copyright © 2015 Elsevier B.V. All rights reserved. JF - Biochimica et biophysica acta AU - Rutardottir, Sigurbjörg AU - Karnaukhova, Elena AU - Nantasenamat, Chanin AU - Songtawee, Napat AU - Prachayasittikul, Virapong AU - Rajabi, Mohsen AU - Rosenlöf, Lena Wester AU - Alayash, Abdu I AU - Åkerström, Bo AD - Division of Infection Medicine, Lund University, Lund, Sweden. ; Laboratory of Biochemistry and Vascular Biology, Division of Hematology Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, MD, USA. ; Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand. ; Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand. ; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand. ; Division of Infection Medicine, Lund University, Lund, Sweden. Electronic address: sigurbjorg.rutardottir@med.lu.se. Y1 - 2016/01// PY - 2016 DA - January 2016 SP - 29 EP - 41 VL - 1864 IS - 1 SN - 0006-3002, 0006-3002 KW - Alpha-Globulins KW - 0 KW - Recombinant Proteins KW - alpha-1-microglobulin KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - Site-directed mutagenesis KW - α(1)-Microglobulin KW - Molecular simulation KW - Oxidation-Reduction KW - Blotting, Western KW - Spectrometry, Fluorescence KW - Recombinant Proteins -- metabolism KW - Mutagenesis, Site-Directed -- methods KW - Humans KW - Surface Plasmon Resonance KW - Circular Dichroism KW - Recombinant Proteins -- chemistry KW - Binding Sites -- genetics KW - Protein Binding KW - Mutation KW - Heme -- chemistry KW - Alpha-Globulins -- chemistry KW - Molecular Dynamics Simulation KW - Protein Structure, Tertiary KW - Heme -- metabolism KW - Alpha-Globulins -- genetics KW - Alpha-Globulins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736680921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Structural+and+biochemical+characterization+of+two+heme+binding+sites+on+%CE%B11-microglobulin+using+site+directed+mutagenesis+and+molecular+simulation.&rft.au=Rutardottir%2C+Sigurbj%C3%B6rg%3BKarnaukhova%2C+Elena%3BNantasenamat%2C+Chanin%3BSongtawee%2C+Napat%3BPrachayasittikul%2C+Virapong%3BRajabi%2C+Mohsen%3BRosenl%C3%B6f%2C+Lena+Wester%3BAlayash%2C+Abdu+I%3B%C3%85kerstr%C3%B6m%2C+Bo&rft.aulast=Rutardottir&rft.aufirst=Sigurbj%C3%B6rg&rft.date=2016-01-01&rft.volume=1864&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/10.1016%2Fj.bbapap.2015.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-19 N1 - Date created - 2015-11-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbapap.2015.10.002 ER - TY - JOUR T1 - Genetic variants in TNFα, TGFB1, PTGS1 and PTGS2 genes are associated with diisocyanate-induced asthma. AN - 1728674039; 25721048 AB - Diisocyanates are the most common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants in inflammatory response genes (TNFα, IL1α, IL1β, IL1RN, IL10, TGFB1, ADAM33, ALOX-5, PTGS1, PTGS2 and NAG-1/GDF15) are associated with increased susceptibility to diisocyanate asthma (DA). These genes were selected based on their role in asthmatic inflammatory processes and previously reported associations with asthma phenotypes. The main study population consisted of 237 Caucasian French Canadians from among a larger sample of 280 diisocyanate-exposed workers in two groups: workers with specific inhalation challenge (SIC) confirmed DA (DA(+), n = 95) and asymptomatic exposed workers (AW, n = 142). Genotyping was performed on genomic DNA, using a 5' nuclease PCR assay. After adjusting for potentially confounding variables of age, smoking status and duration of exposure, the PTGS1 rs5788 and TGFB1 rs1800469 single nucleotide polymorphisms (SNP) showed a protective effect under a dominant model (OR = 0.38; 95% CI = 0.17, 0.89 and OR = 0.38; 95% CI = 0.18, 0.74, respectively) while the TNFα rs1800629 SNP was associated with an increased risk of DA (OR = 2.08; 95% CI = 1.03, 4.17). Additionally, the PTGS2 rs20417 variant showed an association with increased risk of DA in a recessive genetic model (OR = 6.40; 95% CI = 1.06, 38.75). These results suggest that genetic variations in TNFα, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. JF - Journal of immunotoxicology AU - Yucesoy, Berran AU - Kashon, Michael L AU - Johnson, Victor J AU - Lummus, Zana L AU - Fluharty, Kara AU - Gautrin, Denyse AU - Cartier, André AU - Boulet, Louis-Philippe AU - Sastre, Joaquin AU - Quirce, Santiago AU - Tarlo, Susan M AU - Cruz, Maria-Jesus AU - Munoz, Xavier AU - Luster, Michael I AU - Bernstein, David I AD - a Division of Immunology , Allergy and Rheumatology, University of Cincinnati College of Medicine , Cincinnati , OH , USA . ; b CDC/National Institute for Occupational Safety and Health, Health Effects Laboratory Division , Morgantown , WV , USA . ; c BRT-Burleson Research Technologies , Morrisville , NC , USA . ; d Université de Montréal, Hôpital du Sacré-Coeur de Montréal , Montreal , Quebec , Canada . ; e Université Laval, Hôpital Laval , Sainte-Foy , Québec , Canada . ; f Department of Allergy , Fundación Jiménez Díaz and CIBER de Enfermedades Respiratorias CIBERES , Madrid , Spain . ; g Department of Allergy , Hospital La Paz-IdiPAZ and CIBER de Enfermedades Respiratorias CIBERES , Madrid , Spain . ; h Department of Medicine , and. ; j Hospitals Vall D'Hebron, Barcelona and CIBER de Enfermedades Respiratorias CIBERES , Madrid , Spain , and. ; k West Virginia University, School of Public Health , Morgantown , WV , USA. Y1 - 2016 PY - 2016 DA - 2016 SP - 119 EP - 126 VL - 13 IS - 1 KW - TGFB1 protein, human KW - 0 KW - Transforming Growth Factor beta1 KW - Tumor Necrosis Factor-alpha KW - Toluene 2,4-Diisocyanate KW - 17X7AFZ1GH KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - PTGS1 protein, human KW - PTGS2 protein, human KW - Index Medicus KW - inflammation KW - Cytokine KW - occupational asthma KW - diisocyanates KW - single nucleotide polymorphism (SNP) KW - Polymorphism, Single Nucleotide KW - Cyclooxygenase 2 -- genetics KW - DNA Mutational Analysis KW - Humans KW - Genetic Association Studies KW - Inflammation -- genetics KW - Cyclooxygenase 1 -- genetics KW - Transforming Growth Factor beta1 -- genetics KW - Tumor Necrosis Factor-alpha -- genetics KW - Genotype KW - Adult KW - Case-Control Studies KW - Genetic Predisposition to Disease KW - Environmental Exposure -- adverse effects KW - Male KW - Female KW - Toluene 2,4-Diisocyanate -- immunology KW - Asthma, Occupational -- metabolism KW - Asthma, Occupational -- immunology KW - Asthma, Occupational -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728674039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Genetic+variants+in+TNF%CE%B1%2C+TGFB1%2C+PTGS1+and+PTGS2+genes+are+associated+with+diisocyanate-induced+asthma.&rft.au=Yucesoy%2C+Berran%3BKashon%2C+Michael+L%3BJohnson%2C+Victor+J%3BLummus%2C+Zana+L%3BFluharty%2C+Kara%3BGautrin%2C+Denyse%3BCartier%2C+Andr%C3%A9%3BBoulet%2C+Louis-Philippe%3BSastre%2C+Joaquin%3BQuirce%2C+Santiago%3BTarlo%2C+Susan+M%3BCruz%2C+Maria-Jesus%3BMunoz%2C+Xavier%3BLuster%2C+Michael+I%3BBernstein%2C+David+I&rft.aulast=Yucesoy&rft.aufirst=Berran&rft.date=2016-01-01&rft.volume=13&rft.issue=1&rft.spage=119&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.3109%2F1547691X.2015.1017061 LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/1547691X.2015.1017061 ER - TY - JOUR T1 - Understanding the interactions between porphyrin-containing photosensitizers and polymer-coated nanoparticles in model biological environments. AN - 1722930702; 26402781 AB - Non-covalent incorporation of hydrophobic drugs into polymeric systems is a commonly-used strategy for drug delivery because non-covalent interactions minimize modification of the drug molecules whose efficacy is retained upon release. The behaviors of the drug-polymer delivery system in the biological environments it encounters will affect the efficacy of treatment. In this report, we have investigated the interaction between a hydrophobic drug and its encapsulating polymer in model biological environments using a photosensitizer encapsulated in a polymer-coated nanoparticle system. The photosensitizer, 3-(1'-hexyloxyethyl)-3-devinylpyropheophorbide-a (HPPH), was non-covalently incorporated to the poly(ethylene glycol) (PEG) layer coated on Au nanocages (AuNCs) to yield AuNC-HPPH complexes. The non-covalent binding was characterized by Scatchard analysis, fluorescence lifetime, and Raman experiments. The dissociation constant between PEG and HPPH was found to be ∼35 μM with a maximum loading of ∼2.5×10(5) HPPHs/AuNC. The release was studied in serum-mimetic environment and in vesicles that model human cell membranes. The rate of protein-mediated drug release decreased when using a negatively-charged or cross-linked terminus of the surface-modified PEG. Furthermore, the photothermal effect of AuNCs can initiate burst release, and thus allow control of the release kinetics, demonstrating on-demand drug release. This study provides insights regarding the actions and release kinetics of non-covalent drug delivery systems in biological environments. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Journal of colloid and interface science AU - Jenkins, Samir V AU - Srivatsan, Avinash AU - Reynolds, Kimberly Y AU - Gao, Feng AU - Zhang, Yongbin AU - Heyes, Colin D AU - Pandey, Ravindra K AU - Chen, Jingyi AD - Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, United States. ; Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, NY 14263, United States. ; NCTR/ORA Nanotechnology Core Facility, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, United States. Electronic address: chenj@uark.edu. Y1 - 2016/01/01/ PY - 2016 DA - 2016 Jan 01 SP - 225 EP - 231 VL - 461 KW - Photosensitizing Agents KW - 0 KW - Porphyrins KW - Chlorophyll KW - 1406-65-1 KW - 2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a KW - 149402-51-7 KW - Polyethylene Glycols KW - 30IQX730WE KW - Gold KW - 7440-57-5 KW - Index Medicus KW - Drug delivery KW - Gold nanostructure KW - Controlled release KW - PEG coating KW - Drug Delivery Systems KW - Kinetics KW - Humans KW - Cell Membrane KW - Surface Properties KW - Metal Nanoparticles -- chemistry KW - Chlorophyll -- metabolism KW - Porphyrins -- chemistry KW - Photosensitizing Agents -- metabolism KW - Gold -- metabolism KW - Polyethylene Glycols -- metabolism KW - Models, Biological KW - Chlorophyll -- chemistry KW - Porphyrins -- metabolism KW - Photosensitizing Agents -- chemistry KW - Polyethylene Glycols -- chemistry KW - Chlorophyll -- analogs & derivatives KW - Gold -- chemistry KW - Photosensitizing Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722930702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+colloid+and+interface+science&rft.atitle=Understanding+the+interactions+between+porphyrin-containing+photosensitizers+and+polymer-coated+nanoparticles+in+model+biological+environments.&rft.au=Jenkins%2C+Samir+V%3BSrivatsan%2C+Avinash%3BReynolds%2C+Kimberly+Y%3BGao%2C+Feng%3BZhang%2C+Yongbin%3BHeyes%2C+Colin+D%3BPandey%2C+Ravindra+K%3BChen%2C+Jingyi&rft.aulast=Jenkins&rft.aufirst=Samir&rft.date=2016-01-01&rft.volume=461&rft.issue=&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Journal+of+colloid+and+interface+science&rft.issn=1095-7103&rft_id=info:doi/10.1016%2Fj.jcis.2015.09.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-18 N1 - Date created - 2015-10-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jcis.2015.09.037 ER - TY - JOUR T1 - Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing. AN - 1750013064; 25536518 AB - There is a growing impetus to develop more accurate, predictive and relevant in vitro models of renal xenobiotic exposure. As part of the EU-FP7, Predict-IV project, a major aim was to develop models that recapitulate not only normal tissue physiology but also aspects of disease conditions that exist as predisposing risk factors for xenobiotic toxicity. Hypoxia, as a common micro-environmental alteration associated with pathophysiology in renal disease, was investigated for its effect on the toxicity profile of a panel of 14 nephrotoxins, using the human proximal tubular epithelial RPTECT/TERT1 cell line. Changes in ATP, glutathione and resazurin reduction, after 14 days of daily repeat exposure, revealed a number of compounds, including adefovir dipivoxil with enhanced toxicity in hypoxia. We observed intracellular accumulation of adefovir in hypoxia and suggest decreases in the efflux transport proteins MRP4, MRP5, NHERF1 and NHERF3 as a possible explanation. MRP5 and NHERF3 were also down-regulated upon treatment with the HIF-1 activator, dimethyloxalylglycine. Interestingly, adefovir dependent gene expression shifted from alterations in cell cycle gene expression to an inflammatory response in hypoxia. The ability to investigate aspects of disease states and their influence on renal toxin handling is a key advantage of in vitro systems developed here. They also allow for detailed investigations into mechanisms of compound toxicity of potential importance for compromised tissue exposure. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Crean, Daniel AU - Bellwon, Patricia AU - Aschauer, Lydia AU - Limonciel, Alice AU - Moenks, Konrad AU - Hewitt, Philip AU - Schmidt, Tobias AU - Herrgen, Karin AU - Dekant, Wolfgang AU - Lukas, Arno AU - Bois, Frederic AU - Wilmes, Anja AU - Jennings, Paul AU - Leonard, Martin O AD - University College Dublin, School of Medicine and Medical Science, Dublin, Ireland. ; Institut fuer Toxikologie, Universitaet Wuerzburg, Versbacher Str. 9, 97078 Würzburg, Germany. ; Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck 6020, Austria. ; Emergentec Biodevelopment GmbH, Vienna 1180, Austria. ; Merck KGaA, Merck Serono, Nonclinical Safety, Darmstadt 64293, Germany. ; Université de Technologie de Compiègne, Compiègne Cedex 60205, France. ; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot OX11 0RQ, UK. Electronic address: Martin.Leonard@phe.gov.uk. Y1 - 2015/12/25/ PY - 2015 DA - 2015 Dec 25 SP - 128 EP - 137 VL - 30 IS - 1 Pt A KW - Organophosphonates KW - 0 KW - Reverse Transcriptase Inhibitors KW - Xenobiotics KW - Adenine KW - JAC85A2161 KW - Oxygen KW - S88TT14065 KW - adefovir dipivoxil KW - U6Q8Z01514 KW - Index Medicus KW - Nephrotoxicity KW - Chronic kidney disease KW - Proximal tubule KW - Hypoxia KW - Protein Array Analysis KW - Humans KW - Toxicity Tests KW - Gene Expression Regulation -- drug effects KW - Cell Line KW - Kidney Tubules, Proximal -- cytology KW - Organophosphonates -- toxicity KW - Adenine -- toxicity KW - Reverse Transcriptase Inhibitors -- toxicity KW - Epithelium -- pathology KW - Adenine -- analogs & derivatives KW - Epithelium -- drug effects KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1750013064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Development+of+an+in+vitro+renal+epithelial+disease+state+model+for+xenobiotic+toxicity+testing.&rft.au=Crean%2C+Daniel%3BBellwon%2C+Patricia%3BAschauer%2C+Lydia%3BLimonciel%2C+Alice%3BMoenks%2C+Konrad%3BHewitt%2C+Philip%3BSchmidt%2C+Tobias%3BHerrgen%2C+Karin%3BDekant%2C+Wolfgang%3BLukas%2C+Arno%3BBois%2C+Frederic%3BWilmes%2C+Anja%3BJennings%2C+Paul%3BLeonard%2C+Martin+O&rft.aulast=Crean&rft.aufirst=Daniel&rft.date=2015-12-25&rft.volume=30&rft.issue=1+Pt+A&rft.spage=128&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2014.11.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-27 N1 - Date created - 2015-12-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2014.11.015 ER - TY - JOUR T1 - Level 2 validation of a flow cytometric method for detection of Escherichia coli O157:H7 in raw spinach. AN - 1723756667; 26318407 AB - The Bacteriological Analytical Manual (BAM) method currently used by the United States Food and Drug Administration (FDA) to detect Escherichia coli O157:H7 in spinach was systematically compared to a new flow cytometry based method. This Food and Drug Administration (FDA) level 2 external laboratory validation study was designed to determine the latter method's sensitivity and speed for analysis of this pathogen in raw spinach. Detection of target cell inoculations with a low cell count is critical, since enterohemorrhagic strains of E. coli require an infective dose of as few as 10 cells (Schmid-Hempel and Frank, 2007). Although, according to the FDA, the infectious dose is unknown (Food and Drug Administration, 1993). Therefore, the inoculation level into the spinach, a total of 2.0±2.6 viable E. coli O157 cells, was specified to yield between 25% and 75% detection by the new method, out of 20 samples (10 positives and 10 negatives). This criterion was met in that the new method detected 60% of the nominally positive samples; the corresponding sensitivity of the reference method was 50%. For both methods the most likely explanation for false negatives was that no viable cells were actually introduced into the sample. In this validation study, the flow cytometry method was equal to the BAM in sensitivity and far superior in speed. Published by Elsevier B.V. JF - International journal of food microbiology AU - Williams, Anna J AU - Cooper, Willie M AU - Summage-West, Christine V AU - Sims, Lillie M AU - Woodruff, Robert AU - Christman, Jessica AU - Moskal, Ted J AU - Ramsaroop, Shawn AU - Sutherland, John B AU - Alusta, Pierre AU - Wilkes, Jon G AU - Buzatu, Dan A AD - U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Systems Biology, Jefferson, AR 72079, USA. Electronic address: anna.williams@fda.hhs.gov. ; U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Systems Biology, Jefferson, AR 72079, USA. Electronic address: willie.cooper@fda.hhs.gov. ; U.S. Food and Drug Administration, National Center for Toxicological Research, Office of Scientific Coordination, Jefferson, AR 72079, USA. Electronic address: christine.summage-west@fda.hhs.gov. ; U.S. Food and Drug Administration, National Center for Toxicological Research, Office of Scientific Coordination, Jefferson, AR 72079, USA. Electronic address: lillie.sims@fda.hhs.gov. ; U.S. Food and Drug Administration, Arkansas Regional Laboratory, Division of Microbiology, Jefferson, AR 72079, USA. Electronic address: robert.woodruff@fda.hhs.gov. ; U.S. Food and Drug Administration, Arkansas Regional Laboratory, Division of Microbiology, Jefferson, AR 72079, USA. Electronic address: jessica.christman@fda.hhs.gov. ; Ted Moskal, Life Sciences Consultant, 515 W. Matthews Ave., Jonesboro, AR 72401, USA. Electronic address: tmoskal62@gmail.com. ; Vivione Biosciences, LLC, Pine Bluff, AR 71602, USA. Electronic address: sramsaroop@vivionebiosciences.com. ; U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Microbiology, Jefferson, AR 72079, USA. Electronic address: john.sutherland@fda.hhs.gov. ; U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Systems Biology, Jefferson, AR 72079, USA. Electronic address: pierre.alusta@fda.hhs.gov. ; U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Systems Biology, Jefferson, AR 72079, USA. Electronic address: jon.wilkes@fda.hhs.gov. ; U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Systems Biology, Jefferson, AR 72079, USA. Electronic address: dan.buzatu@fda.hhs.gov. Y1 - 2015/12/23/ PY - 2015 DA - 2015 Dec 23 SP - 1 EP - 6 VL - 215 KW - Index Medicus KW - Flow cytometry KW - Escherichia coli O157 KW - Food pathogens KW - Microorganisms KW - Public health KW - United States KW - United States Food and Drug Administration KW - Flow Cytometry -- standards KW - Escherichia coli O157 -- isolation & purification KW - Spinacia oleracea -- microbiology KW - Food Microbiology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1723756667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Level+2+validation+of+a+flow+cytometric+method+for+detection+of+Escherichia+coli+O157%3AH7+in+raw+spinach.&rft.au=Williams%2C+Anna+J%3BCooper%2C+Willie+M%3BSummage-West%2C+Christine+V%3BSims%2C+Lillie+M%3BWoodruff%2C+Robert%3BChristman%2C+Jessica%3BMoskal%2C+Ted+J%3BRamsaroop%2C+Shawn%3BSutherland%2C+John+B%3BAlusta%2C+Pierre%3BWilkes%2C+Jon+G%3BBuzatu%2C+Dan+A&rft.aulast=Williams&rft.aufirst=Anna&rft.date=2015-12-23&rft.volume=215&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=1879-3460&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2015.08.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-09 N1 - Date created - 2015-10-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2015.08.011 ER - TY - JOUR T1 - Development and Validation of Decision Forest Model for Estrogen Receptor Binding Prediction of Chemicals Using Large Data Sets. AN - 1751194951; 26524122 AB - Some chemicals in the environment possess the potential to interact with the endocrine system in the human body. Multiple receptors are involved in the endocrine system; estrogen receptor α (ERα) plays very important roles in endocrine activity and is the most studied receptor. Understanding and predicting estrogenic activity of chemicals facilitates the evaluation of their endocrine activity. Hence, we have developed a decision forest classification model to predict chemical binding to ERα using a large training data set of 3308 chemicals obtained from the U.S. Food and Drug Administration's Estrogenic Activity Database. We tested the model using cross validations and external data sets of 1641 chemicals obtained from the U.S. Environmental Protection Agency's ToxCast project. The model showed good performance in both internal (92% accuracy) and external validations (∼ 70-89% relative balanced accuracies), where the latter involved the validations of the model across different ER pathway-related assays in ToxCast. The important features that contribute to the prediction ability of the model were identified through informative descriptor analysis and were related to current knowledge of ER binding. Prediction confidence analysis revealed that the model had both high prediction confidence and accuracy for most predicted chemicals. The results demonstrated that the model constructed based on the large training data set is more accurate and robust for predicting ER binding of chemicals than the published models that have been developed using much smaller data sets. The model could be useful for the evaluation of ERα-mediated endocrine activity potential of environmental chemicals. JF - Chemical research in toxicology AU - Ng, Hui Wen AU - Doughty, Stephen W AU - Luo, Heng AU - Ye, Hao AU - Ge, Weigong AU - Tong, Weida AU - Hong, Huixiao AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration , 3900 NCTR Road, Jefferson, Arkansas 72079, United States. ; School of Pharmacy, University of Nottingham Malaysia Campus , Jalan Broga, 43500 Semenyih, Selangor, Malaysia. Y1 - 2015/12/21/ PY - 2015 DA - 2015 Dec 21 SP - 2343 EP - 2351 VL - 28 IS - 12 KW - Endocrine Disruptors KW - 0 KW - Receptors, Estrogen KW - Small Molecule Libraries KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Quantitative Structure-Activity Relationship KW - Humans KW - Protein Binding KW - Receptors, Estrogen -- drug effects KW - Small Molecule Libraries -- pharmacology KW - Receptors, Estrogen -- chemistry KW - Small Molecule Libraries -- chemistry KW - Models, Theoretical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751194951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Development+and+Validation+of+Decision+Forest+Model+for+Estrogen+Receptor+Binding+Prediction+of+Chemicals+Using+Large+Data+Sets.&rft.au=Ng%2C+Hui+Wen%3BDoughty%2C+Stephen+W%3BLuo%2C+Heng%3BYe%2C+Hao%3BGe%2C+Weigong%3BTong%2C+Weida%3BHong%2C+Huixiao&rft.aulast=Ng&rft.aufirst=Hui&rft.date=2015-12-21&rft.volume=28&rft.issue=12&rft.spage=2343&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.5b00358 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-08 N1 - Date created - 2015-12-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00358 ER - TY - JOUR T1 - Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A. AN - 1737478304; 26522835 AB - A previously developed physiologically based pharmacokinetic (PBPK) model for bisphenol A (BPA) in adult rhesus monkeys was modified to characterize the pharmacokinetics of BPA and its phase II conjugates in adult humans following oral ingestion. Coupled with in vitro studies on BPA metabolism in the liver and the small intestine, the PBPK model was parameterized using oral pharmacokinetic data with deuterated-BPA (d6-BPA) delivered in cookies to adult humans after overnight fasting. The availability of the serum concentration time course of unconjugated d6-BPA offered direct empirical evidence for the calibration of BPA model parameters. The recalibrated PBPK adult human model for BPA was then evaluated against published human pharmacokinetic studies with BPA. A hypothesis of decreased oral uptake was needed to account for the reduced peak levels observed in adult humans, where d6-BPA was delivered in soup and food was provided prior to BPA ingestion, suggesting the potential impact of dosing vehicles and/or fasting on BPA disposition. With the incorporation of Monte Carlo analysis, the recalibrated adult human model was used to address the inter-individual variability in the internal dose metrics of BPA for the U.S. general population. Model-predicted peak BPA serum levels were in the range of pM, with 95% of human variability falling within an order of magnitude. This recalibrated PBPK model for BPA in adult humans provides a scientific basis for assessing human exposure to BPA that can serve to minimize uncertainties incurred during extrapolations across doses and species. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Yang, Xiaoxia AU - Doerge, Daniel R AU - Teeguarden, Justin G AU - Fisher, Jeffrey W AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: xiaoxia.yang@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99352, United States; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, United States. Y1 - 2015/12/15/ PY - 2015 DA - 2015 Dec 15 SP - 442 EP - 456 VL - 289 IS - 3 KW - Air Pollutants, Occupational KW - 0 KW - Benzhydryl Compounds KW - Phenols KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Bisphenol A KW - PBPK KW - Physiologically based pharmacokinetic model KW - Human KW - BPA KW - Administration, Oral KW - Young Adult KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Liver -- metabolism KW - Tissue Distribution KW - Monte Carlo Method KW - Species Specificity KW - Models, Biological KW - Male KW - Female KW - Benzhydryl Compounds -- pharmacokinetics KW - Phenols -- blood KW - Phenols -- pharmacokinetics KW - Benzhydryl Compounds -- blood KW - Air Pollutants, Occupational -- pharmacokinetics KW - Air Pollutants, Occupational -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737478304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Development+of+a+physiologically+based+pharmacokinetic+model+for+assessment+of+human+exposure+to+bisphenol+A.&rft.au=Yang%2C+Xiaoxia%3BDoerge%2C+Daniel+R%3BTeeguarden%2C+Justin+G%3BFisher%2C+Jeffrey+W&rft.aulast=Yang&rft.aufirst=Xiaoxia&rft.date=2015-12-15&rft.volume=289&rft.issue=3&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.10.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-07 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.10.016 ER - TY - JOUR T1 - Application of physiologically-based pharmacokinetic modeling to explore the role of kidney transporters in renal reabsorption of perfluorooctanoic acid in the rat. AN - 1737477254; 26522833 AB - Renal elimination and the resulting clearance of perfluorooctanoic acid (PFOA) from the serum exhibit pronounced sex differences in the adult rat. The literature suggests that this is largely due to hormonally regulated expression of organic anion transporters (OATs) on the apical and basolateral membranes of the proximal tubule cells that facilitate excretion and reabsorption of PFOA from the filtrate into the blood. Previously developed PBPK models of PFOA exposure in the rat have not been parameterized to specifically account for transporter-mediated renal elimination. We developed a PBPK model for PFOA in male and female rats to explore the role of Oat1, Oat3, and Oatp1a1 in sex-specific renal reabsorption and excretion of PFOA. Descriptions of the kinetic behavior of these transporters were extrapolated from in vitro studies and the model was used to simulate time-course serum, liver, and urine data for intravenous (IV) and oral exposures in both sexes. Model predicted concentrations of PFOA in the liver, serum, and urine showed good agreement with experimental data for both male and female rats indicating that in vitro derived physiological descriptions of transporter-mediated renal reabsorption can successfully predict sex-dependent excretion of PFOA in the rat. This study supports the hypothesis that sex-specific serum half-lives for PFOA are largely driven by expression of transporters in the kidney and contribute to the development of PBPK modeling as a tool for evaluating the role of transporters in renal clearance. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Worley, Rachel Rogers AU - Fisher, Jeffrey AD - Agency for Toxic Substances and Disease Registry, Division of Community Health Investigations, 4770 Buford Highway, Atlanta, GA 30341, United States; Interdisciplinary Toxicology Program, University of Georgia, 341 Pharmacy South, Athens, GA 30602, United States. Electronic address: idz7@cdc.gov. ; Interdisciplinary Toxicology Program, University of Georgia, 341 Pharmacy South, Athens, GA 30602, United States; Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, United States. Y1 - 2015/12/15/ PY - 2015 DA - 2015 Dec 15 SP - 428 EP - 441 VL - 289 IS - 3 KW - Caprylates KW - 0 KW - Fluorocarbons KW - Membrane Transport Proteins KW - Organic Anion Transporters KW - perfluorooctanoic acid KW - 947VD76D3L KW - Index Medicus KW - PBPK KW - PFOA KW - Oatp1a1 KW - Oat1 KW - Oat3 KW - IVIVE KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Sex Characteristics KW - Rats, Wistar KW - Membrane Transport Proteins -- metabolism KW - Male KW - Female KW - Kidney Tubules, Proximal -- physiology KW - Renal Reabsorption -- physiology KW - Kidney Tubules, Proximal -- metabolism KW - Caprylates -- metabolism KW - Organic Anion Transporters -- metabolism KW - Fluorocarbons -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737477254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Application+of+physiologically-based+pharmacokinetic+modeling+to+explore+the+role+of+kidney+transporters+in+renal+reabsorption+of+perfluorooctanoic+acid+in+the+rat.&rft.au=Worley%2C+Rachel+Rogers%3BFisher%2C+Jeffrey&rft.aulast=Worley&rft.aufirst=Rachel&rft.date=2015-12-15&rft.volume=289&rft.issue=3&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.10.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-07 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Reprod Toxicol. 2012 Jul;33(4):452-67 [21565266] Endocrinology. 1998 Apr;139(4):1581-7 [9528937] Environ Health Perspect. 2013 Nov-Dec;121(11-12):1313-8 [24007715] Clin Pharmacokinet. 2014 Mar;53(3):283-93 [24214317] Expert Opin Drug Discov. 2014 Aug;9(8):873-90 [24857286] Eur J Pharm Sci. 2014 Dec 18;65:156-66 [25261337] Drug Chem Toxicol. 2000 Nov;23(4):603-20 [11071397] Chem Biol Interact. 2002 Mar 20;139(3):301-16 [11879818] J Pharmacol Exp Ther. 2002 Apr;301(1):145-51 [11907168] Pharmacol Rev. 2003 Jun;55(2):229-40 [12773628] Chem Res Toxicol. 2003 Jun;16(6):775-81 [12807361] Toxicology. 2004 Mar 1;196(1-2):95-116 [15036760] Toxicol Appl Pharmacol. 2004 Jul 15;198(2):231-41 [15236955] J Steroid Biochem. 1982 Aug;17(2):211-6 [7109606] J Biochem. 1985 Aug;98(2):475-82 [4066651] Fundam Appl Toxicol. 1984 Dec;4(6):972-6 [6519377] J Nutr. 1999 Apr;129(4):896-902 [10203567] Toxicol Sci. 2005 May;85(1):476-90 [15716482] Environ Res. 2005 Oct;99(2):253-61 [16194675] Toxicol Sci. 2006 Jan;89(1):93-107 [16221955] Toxicol Sci. 2006 Apr;90(2):510-8 [16415327] Environ Sci Technol. 2006 Apr 1;40(7):2128-34 [16646443] Toxicology. 2006 Oct 3;227(1-2):156-64 [16978759] Biol Pharm Bull. 2007 Aug;30(8):1535-40 [17666816] J Occup Environ Med. 2007 Aug;49(8):872-9 [17693785] Environ Health Perspect. 2007 Sep;115(9):1298-305 [17805419] J Occup Environ Med. 2007 Oct;49(10):1086-96 [18000414] Environ Health Perspect. 2007 Nov;115(11):1596-602 [18007991] Drug Metab Dispos. 2007 Dec;35(12):2166-76 [17823233] Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):1-8 [18373647] Arch Environ Contam Toxicol. 2009 Feb;56(2):338-49 [18661093] Toxicol Sci. 2009 Feb;107(2):331-41 [19005225] Toxicol Lett. 2009 Oct 28;190(2):163-71 [19616083] Nucleic Acids Res. 2010 Jan;38(Database issue):D750-3 [19854939] Arch Environ Contam Toxicol. 2010 Jan;58(1):205-13 [19468665] Toxicol Sci. 2010 Feb;113(2):305-14 [19915082] Environ Health Perspect. 2010 Feb;118(2):222-8 [20123620] Nat Rev Drug Discov. 2010 Mar;9(3):215-36 [20190787] Toxicol Sci. 2010 Oct;117(2):294-302 [20639259] Toxicology. 2011 Mar 15;281(1-3):48-55 [21237237] Biochem Pharmacol. 1983 Dec 15;32(24):3797-801 [6661253] Metabolism. 1986 Apr;35(4):343-8 [3959904] J Biochem Toxicol. 1991 Summer;6(2):83-92 [1941903] Xenobiotica. 1991 Sep;21(9):1119-25 [1788980] Pharm Res. 1993 Jul;10(7):1093-5 [8378254] Toxicol Appl Pharmacol. 1994 Sep;128(1):36-44 [8079352] Xenobiotica. 1995 Jan;25(1):37-47 [7604605] Toxicology. 1995 May 23;99(3):169-78 [7610463] Toxicol Ind Health. 1997 Jul-Aug;13(4):407-84 [9249929] Environ Sci Technol. 2012 Jun 5;46(11):6330-8 [22554481] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.10.017 ER - TY - JOUR T1 - Diacetyl and 2,3-pentanedione exposure of human cultured airway epithelial cells: Ion transport effects and metabolism of butter flavoring agents. AN - 1737477072; 26454031 AB - Inhalation of butter flavoring by workers in the microwave popcorn industry may result in “popcorn workers' lung.” In previous in vivo studies rats exposed for 6 h to vapor from the flavoring agents, diacetyl and 2,3-pentanedione, acquired flavoring concentration-dependent damage of the upper airway epithelium and airway hyporeactivity to inhaled methacholine. Because ion transport is essential for lung fluid balance,we hypothesized that alterations in ion transport may be an early manifestation of butter flavoring-induced toxicity.We developed a system to expose cultured human bronchial/tracheal epithelial cells (NHBEs) to flavoring vapors. NHBEs were exposed for 6 h to diacetyl or 2,3-pentanedione vapors (25 or ≥ 60 ppm) and the effects on short circuit current and transepithelial resistance (Rt) were measured. Immediately after exposure to 25 ppm both flavorings reduced Na+ transport,without affecting Cl- transport or Na+,K+-pump activity. Rt was unaffected. Na+ transport recovered 18 h after exposure. Concentrations (100-360 ppm) of diacetyl and 2,3-pentanedione reported earlier to give rise in vivo to epithelial damage, and 60 ppm, caused death of NHBEs 0 h post-exposure. Analysis of the basolateral medium indicated that NHBEs metabolize diacetyl and 2,3-pentanedione to acetoin and 2-hydroxy-3-pentanone, respectively. The results indicate that ion transport is inhibited transiently in airway epithelial cells by lower concentrations of the flavorings than those that result in morphological changes of the cells in vivo or in vitro. JF - Toxicology and applied pharmacology AU - Zaccone, Eric J AU - Goldsmith, W Travis AU - Shimko, Michael J AU - Wells, J R AU - Schwegler-Berry, Diane AU - Willard, Patsy A AU - Case, Shannon L AU - Thompson, Janet A AU - Fedan, Jeffrey S AD - Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA. ; Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA. ; Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, USA; Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Y1 - 2015/12/15/ PY - 2015 DA - 2015 Dec 15 SP - 542 EP - 549 VL - 289 IS - 3 KW - Flavoring Agents KW - 0 KW - Pentanones KW - Methacholine Chloride KW - 0W5ETF9M2K KW - Butter KW - 8029-34-3 KW - Diacetyl KW - K324J5K4HM KW - 2,3-pentanedione KW - K4WBE45SCM KW - Index Medicus KW - Dicarbonyl/l-xylulose reductase KW - Ion transport KW - Human airway epithelial cells KW - Vapor exposure KW - 2,3-Pentanedione KW - Microwaves KW - Cells, Cultured KW - Humans KW - Occupational Exposure -- adverse effects KW - Methacholine Chloride -- adverse effects KW - Inhalation Exposure -- adverse effects KW - Ion Transport -- drug effects KW - Epithelial Cells -- drug effects KW - Diacetyl -- adverse effects KW - Flavoring Agents -- adverse effects KW - Pentanones -- adverse effects KW - Bronchi -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737477072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Diacetyl+and+2%2C3-pentanedione+exposure+of+human+cultured+airway+epithelial+cells%3A+Ion+transport+effects+and+metabolism+of+butter+flavoring+agents.&rft.au=Zaccone%2C+Eric+J%3BGoldsmith%2C+W+Travis%3BShimko%2C+Michael+J%3BWells%2C+J+R%3BSchwegler-Berry%2C+Diane%3BWillard%2C+Patsy+A%3BCase%2C+Shannon+L%3BThompson%2C+Janet+A%3BFedan%2C+Jeffrey+S&rft.aulast=Zaccone&rft.aufirst=Eric&rft.date=2015-12-15&rft.volume=289&rft.issue=3&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-07 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Sci. 2009 Mar;108(1):173-83 [18940962] Occup Environ Med. 2009 Feb;66(2):105-10 [18805877] J Physiol. 2010 Nov 1;588(Pt 21):4089-101 [20819947] J Agric Food Chem. 2010 Dec 22;58(24):12761-8 [21077678] J Occup Environ Hyg. 2011 Feb;8(2):93-103 [21253982] PLoS One. 2011;6(3):e17644 [21464978] Toxicol Sci. 2011 Sep;123(1):231-46 [21705714] J Biomed Biotechnol. 2011;2011:174306 [22131798] Toxicol Pathol. 2012 Apr;40(3):448-65 [22215510] Am J Pathol. 2012 Sep;181(3):829-44 [22894831] Pharmacol Ther. 2012 Dec;136(3):401-13 [22964085] Chem Biol Interact. 2013 Feb 25;202(1-3):195-203 [23295224] J Toxicol Environ Health A. 2013;76(11):669-89 [23941636] Toxicol Sci. 2014 Nov;142(1):126-36 [25145656] Am J Physiol Lung Cell Mol Physiol. 2002 Feb;282(2):L226-36 [11792627] Chem Biol Interact. 2001 Jan 30;130-132(1-3):879-89 [11306103] Biol Rev Camb Philos Soc. 2015 Feb;90(1):254-78 [24720935] J Biol Chem. 2002 May 17;277(20):17883-91 [11882650] Physiol Rev. 2002 Jul;82(3):569-600 [12087129] N Engl J Med. 2002 Aug 1;347(5):330-8 [12151470] Toxicol Appl Pharmacol. 2002 Dec 1;185(2):128-35 [12490137] Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L320-30 [14527933] J Pharmacol Exp Ther. 2004 Jan;308(1):19-29 [14566000] Eur Respir J. 2004 Aug;24(2):298-302 [15332401] Biochemistry. 1975 Oct 21;14(21):4699-704 [1237312] J Biol Chem. 1989 Nov 5;264(31):18296-301 [2681195] Biochemistry. 1995 Mar 21;34(11):3536-43 [7893649] Eur Respir J. 1999 May;13(5):1177-88 [10414423] J Physiol. 2004 Nov 1;560(Pt 3):857-65 [15308680] Proc Am Thorac Soc. 2004;1(1):62-5 [16113414] Toxicol Appl Pharmacol. 2006 Aug 15;215(1):17-22 [16545411] Am J Respir Crit Care Med. 2007 Sep 1;176(5):498-504 [17541015] Toxicol Sci. 2008 May;103(1):169-80 [18227102] Toxicol Pathol. 2008 Feb;36(2):330-44 [18474946] Eur Respir J. 2009 Jul;34(1):63-71 [19567602] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.10.004 ER - TY - JOUR T1 - Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells. AN - 1735902749; 26428001 AB - Observed variations in drug responses among patients may result from differences in heritable genetic traits or from alterations in the epigenetic regulation of drug metabolizing enzymes and transporters (DMETs). MicroRNAs (miRNAs), a group of small non-coding RNAs, provide an epigenetic mechanism for fine-tuning the expression of targeted DMET genes by regulating the efficiency of protein translation and by decreasing mRNA stability via enhanced degradation. In the current study we systematically screened 374 important genes encoding DMETs for potential response elements to hsa-miR-29a-3p, a highly abundant miRNA in human liver. RNA electrophoresis mobility shift assays displayed direct interactions between hsa-miR-29a-3p and its cognate targets within the mRNA transcripts for the ABCC6, SLC22A7 and ALDH5A1 genes. The expression of luciferase reporter genes containing the 3'-UTRs of SLC22A7 or ALDH5A1 and the expression of endogenous SLC22A7 and ALDH5A1 were each suppressed by transfection with hsa-miR-29a-3p mimics. Importantly, chemically-induced up-regulation of hsa-miR-29a-3p correlated inversely with the expression of SLC22A7 and ALDH5A1. However, our studies failed to detect suppressive effects of hsa-miR-29a-3p on ABCC6 expression, which might be explained by the notion that the interaction of hsa-miR-29a-3p and ABCC6 mRNA was unable to recruit ribonucleoproteins to form a RNA-induced silencing complex. Published by Elsevier Inc. JF - Biochemical pharmacology AU - Yu, Dianke AU - Tolleson, William H AU - Knox, Bridgett AU - Jin, Yaqiong AU - Guo, Lei AU - Guo, Yongli AU - Kadlubar, Susan A AU - Ning, Baitang AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. ; University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: baitang.ning@fda.hhs.gov. Y1 - 2015/12/15/ PY - 2015 DA - 2015 Dec 15 SP - 671 EP - 680 VL - 98 IS - 4 KW - MIRN29 microRNA, human KW - 0 KW - MicroRNAs KW - Organic Anion Transporters, Sodium-Independent KW - SLC22A7 protein, human KW - ALDH5A1 protein, human KW - EC 1.2.1.24 KW - Succinate-Semialdehyde Dehydrogenase KW - Index Medicus KW - Pharmacogenomics KW - ALDH5A1 KW - SLC22A7 KW - hsa-miR-29a-3p KW - Drug metabolizing enzymes and transporters KW - microRNA KW - Hep G2 Cells KW - Humans KW - HEK293 Cells KW - Hepatocytes -- drug effects KW - MicroRNAs -- metabolism KW - Succinate-Semialdehyde Dehydrogenase -- antagonists & inhibitors KW - Organic Anion Transporters, Sodium-Independent -- antagonists & inhibitors KW - MicroRNAs -- genetics KW - Organic Anion Transporters, Sodium-Independent -- physiology KW - Succinate-Semialdehyde Dehydrogenase -- physiology KW - MicroRNAs -- pharmacology KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735902749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Modulation+of+ALDH5A1+and+SLC22A7+by+microRNA+hsa-miR-29a-3p+in+human+liver+cells.&rft.au=Yu%2C+Dianke%3BTolleson%2C+William+H%3BKnox%2C+Bridgett%3BJin%2C+Yaqiong%3BGuo%2C+Lei%3BGuo%2C+Yongli%3BKadlubar%2C+Susan+A%3BNing%2C+Baitang&rft.aulast=Yu&rft.aufirst=Dianke&rft.date=2015-12-15&rft.volume=98&rft.issue=4&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2015.09.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-14 N1 - Date created - 2015-11-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcp.2015.09.020 ER - TY - JOUR T1 - Subgroup identification for treatment selection in biomarker adaptive design. AN - 1747328278; 26646831 AB - Advances in molecular technology have shifted new drug development toward targeted therapy for treatments expected to benefit subpopulations of patients. Adaptive signature design (ASD) has been proposed to identify the most suitable target patient subgroup to enhance efficacy of treatment effect. There are two essential aspects in the development of biomarker adaptive designs: 1) an accurate classifier to identify the most appropriate treatment for patients, and 2) statistical tests to detect treatment effect in the relevant population and subpopulations. We propose utilization of classification methods to identity patient subgroups and present a statistical testing strategy to detect treatment effects. The diagonal linear discriminant analysis (DLDA) is used to identify targeted and non-targeted subgroups. For binary endpoints, DLDA is directly applied to classify patient into two subgroups; for continuous endpoints, a two-step procedure involving model fitting and determination of a cutoff-point is used for subgroup classification. The proposed strategy includes tests for treatment effect in all patients and in a marker-positive subgroup, with a possible follow-up estimation of treatment effect in the marker-negative subgroup. The proposed method is compared to the ASD classification method using simulated datasets and two publically available cancer datasets. The DLDA-based classifier performs well in terms of sensitivity, specificity, positive and negative predictive values, and accuracy in the simulation data and the two cancer datasets, with superior accuracy compared to the ASD method. The subgroup testing strategy is shown to be useful in detecting treatment effect in terms of power and control of study-wise error. Accuracy of a classifier is essential for adaptive designs. A poor classifier not only assigns patients to inappropriate treatments, but also reduces the power of the test, resulting in incorrect conclusions. The proposed procedure provides an effective approach for subgroup identification and subgroup analysis. JF - BMC medical research methodology AU - Lu, Tzu-Pin AU - Chen, James J AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA. tplu@ntu.edu.tw. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, HFT-20, Jefferson, AR, 72079, USA. jamesj.chen@fda.hhs.gov. Y1 - 2015/12/09/ PY - 2015 DA - 2015 Dec 09 SP - 105 VL - 15 KW - Biomarkers, Tumor KW - 0 KW - Index Medicus KW - Disease-Free Survival KW - Computer Simulation KW - Endpoint Determination KW - Humans KW - Algorithms KW - Models, Statistical KW - Patient Selection KW - Adenocarcinoma -- diagnosis KW - Lung Neoplasms -- diagnosis KW - Precision Medicine -- methods KW - Biomarkers, Tumor -- analysis KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1747328278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+medical+research+methodology&rft.atitle=Subgroup+identification+for+treatment+selection+in+biomarker+adaptive+design.&rft.au=Lu%2C+Tzu-Pin%3BChen%2C+James+J&rft.aulast=Lu&rft.aufirst=Tzu-Pin&rft.date=2015-12-09&rft.volume=15&rft.issue=&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=BMC+medical+research+methodology&rft.issn=1471-2288&rft_id=info:doi/10.1186%2Fs12874-015-0098-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-22 N1 - Date created - 2015-12-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Clin Cancer Res. 2005 Nov 1;11(21):7872-8 [16278411] Kidney Int. 2006 Jul;70(1):199-203 [16710348] J Natl Cancer Inst. 2007 Jul 4;99(13):1036-43 [17596577] Nat Rev Cancer. 2003 Apr;3(4):303-9 [12671669] Clin Cancer Res. 2002 Apr;8(4):935-8 [11948095] J Natl Cancer Inst. 2002 Jan 16;94(2):78-9 [11792737] Pharm Stat. 2015 Jul-Aug;14(4):284-93 [25914330] J Biopharm Stat. 2014;24(1):168-87 [24392984] J Biopharm Stat. 2014;24(1):130-53 [24392982] J Biopharm Stat. 2014;24(1):110-29 [24392981] BMC Med Res Methodol. 2012;12:102 [22824262] Pharmacogenomics. 2012 Jan;13(2):147-57 [22188363] Pharm Stat. 2011 Nov-Dec;10(6):494-507 [22162336] J Natl Cancer Inst. 2011 Dec 21;103(24):1859-70 [22157961] Clin Cancer Res. 2011 Nov 1;17(21):6634-40 [22046024] Stat Med. 2011 Oct 30;30(24):2867-80 [21815180] Stat Med. 2011 Sep 20;30(21):2601-21 [21786278] Expert Rev Mol Diagn. 2011 Mar;11(2):171-82 [21405968] J Clin Oncol. 2010 Oct 10;28(29):4417-24 [20823422] Clin Trials. 2010 Oct;7(5):574-83 [20667935] Clin Cancer Res. 2010 Jan 15;16(2):691-8 [20068112] J Natl Cancer Inst. 2009 Nov 4;101(21):1453-63 [19855077] Brief Bioinform. 2009 Sep;10(5):537-46 [19346320] Biom J. 2009 Apr;51(2):358-74 [19358222] Artif Intell Med. 2007 Nov;41(3):197-207 [17719213] Pediatr Nephrol. 2007 Dec;22(12):2089-95 [17874137] Nat Med. 2008 Aug;14(8):822-7 [18641660] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12874-015-0098-7 ER - TY - JOUR T1 - Characterization of extended-spectrum β-lactamase (ESBL) producing non-typhoidal Salmonella (NTS) from imported food products. AN - 1722933350; 26210532 AB - Food contaminated with extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica has emerged as an important global issue due to the international food-product trade. Therefore, the purpose of this study was to investigate whether imported food products can serve as a reservoir for non-typhoidal Salmonella (NTS) that can transmit β-lactam-resistance to humans through ingestion of the contaminated food. NTS isolates (n=110) were collected from various imported food products (n=3480) from 2011 to 2013. The NTS isolates were analyzed by serotyping, antimicrobial susceptibility tests, and plasmid profiling. Salmonella ser. Weltevreden, Salmonella ser. Newport, Salmonella ser. Senftenberg, Salmonella ser. Virchow, Salmonella ser. Enteritidis, Salmonella ser. Typhimurium, and Salmonella ser. Bareilly were the most prevalent serovars. Nine NTS strains were resistant to ampicillin and/or one or more cephalosporins (MIC>32 μg/mL). Polymerase chain reaction (PCR) detection revealed that all nine isolates carried the bla(TEM-1) β-lactamase gene, with or without the bla(CTX-M-9) or bla(OXA-1) genes. Two isolates, PSS_913 and PSS_988, exhibited decreased susceptibility to extended-spectrum cephalosporins and ampicillin. Plasmids ranging in size from less than 8 to over 165 kbp, from all of the 9 resistant isolates, belonged to the IncHI1, IncI1, IncN, or IncX groups. Conjugation experiments and Southern hybridization, using bla(TEM-1), confirmed the plasmid-mediated transfer of ESBL genes, which resulted in increased MICs of β-lactams for Escherichia coli transconjugants. The contamination of imported food products by NTS with conjugative plasmid-borne ESBL genes may contribute to the spread of ESBL-producing NTS and compromise the therapeutic activity of extended-spectrum β-lactam antibiotics. Published by Elsevier B.V. JF - International journal of food microbiology AU - Bae, Dongryeoul AU - Cheng, Chorng-Ming AU - Khan, Ashraf A AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; Pacific Regional Laboratory-Southwest, U.S. Food and Drug Administration, Irvine, CA 92612, United States. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: Ashraf.Khan@fda.hhs.gov. Y1 - 2015/12/02/ PY - 2015 DA - 2015 Dec 02 SP - 12 EP - 17 VL - 214 KW - Anti-Bacterial Agents KW - 0 KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Conjugation KW - Salmonella enterica KW - Food KW - ESBL KW - Antimicrobial resistance KW - beta-Lactam Resistance -- genetics KW - Plasmids -- genetics KW - Anti-Bacterial Agents -- pharmacology KW - Serotyping KW - Microbial Sensitivity Tests KW - beta-Lactamases -- genetics KW - Salmonella -- drug effects KW - Salmonella -- genetics KW - Salmonella -- physiology KW - Food Microbiology KW - Salmonella -- isolation & purification KW - Salmonella -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722933350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+food+microbiology&rft.atitle=Characterization+of+extended-spectrum+%CE%B2-lactamase+%28ESBL%29+producing+non-typhoidal+Salmonella+%28NTS%29+from+imported+food+products.&rft.au=Bae%2C+Dongryeoul%3BCheng%2C+Chorng-Ming%3BKhan%2C+Ashraf+A&rft.aulast=Bae&rft.aufirst=Dongryeoul&rft.date=2015-12-02&rft.volume=214&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=International+journal+of+food+microbiology&rft.issn=1879-3460&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2015.07.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-03 N1 - Date created - 2015-10-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2015.07.017 ER - TY - JOUR T1 - Breast magnetic resonance imaging (MRI) surveillance in breast cancer survivors AN - 1868306312; PQ0004033545 AB - As the breast cancer survivor population increases, the topic of screening these women for recurrences is increasingly relevant. In our institution, we use both breast MRI and mammography in the surveillance of breast cancer survivors, although little data exists on the use of MRI in this setting. We present a retrospective analysis of our experience and compare the sensitivity and specificity of MRI vs. mammography in this setting. We identified women under 65 with a history of breast cancer and at least one follow-up MRI performed along with a mammogram done within 6 months of the MRI. We compared the outcomes of MRI and mammography in terms of biopsies performed as well as in detection of new cancers. Of 617 charts reviewed, 249 patients met inclusion criteria, with 571 paired MRI/mammogram results. There were 27 biopsies performed due to MRI findings alone, 10 done due to mammographic findings alone, and 15 done based on abnormalities seen on both imaging modalities. There were 8 malignancies identified based on an abnormal MRI, 3 detected on both MRI and mammography, and none identified via mammography alone. Overall, MRI had a sensitivity of 84.6% (the 95% CI 54.6-98.1) and a specificity of 95.3% (the 95% CI 93.3-96.9); mammography a sensitivity of 23.1% (the 95% CI 5.0-53.8), and a specificity of 96.4% (the 95% CI 94.5-97.8). Breast MRI is a useful surveillance modality in breast cancer survivors and may be more sensitive at detecting recurrences than mammography alone in this population. JF - SpringerPlus AU - Weinstock, Chana AU - Campassi, Cristina AU - Goloubeva, Olga AU - Wooten, Kathleen AU - Kesmodel, Susan AU - Bellevance, Emily AU - Feigenberg, Steven AU - Ioffe, Olga AU - Tkaczuk, Katherine H R AD - grid.411024.2, 0000000121754264, University of Maryland Greenebaum Cancer Center, 22 South Greene Street, RM S9D, Baltimore, MD, 21201, USA, chana.weinstock@fda.hhs.gov Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1 EP - 8 PB - Springer Science & Business Media, Cham VL - 4 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Malignancy KW - Mammography KW - Magnetic resonance imaging KW - Computed tomography KW - Breast cancer KW - Biopsy KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868306312?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SpringerPlus&rft.atitle=Breast+magnetic+resonance+imaging+%28MRI%29+surveillance+in+breast+cancer+survivors&rft.au=Weinstock%2C+Chana%3BCampassi%2C+Cristina%3BGoloubeva%2C+Olga%3BWooten%2C+Kathleen%3BKesmodel%2C+Susan%3BBellevance%2C+Emily%3BFeigenberg%2C+Steven%3BIoffe%2C+Olga%3BTkaczuk%2C+Katherine+H+R&rft.aulast=Weinstock&rft.aufirst=Chana&rft.date=2015-12-01&rft.volume=4&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=SpringerPlus&rft.issn=2193-1801&rft_id=info:doi/10.1186%2Fs40064-015-1158-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Number of references - 42 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Malignancy; Mammography; Computed tomography; Magnetic resonance imaging; Breast cancer; Biopsy DO - http://dx.doi.org/10.1186/s40064-015-1158-5 ER - TY - JOUR T1 - PubChem structure-activity relationship (SAR) clusters AN - 1837306032; PQ0003733462 AB - Developing structure-activity relationships (SARs) of molecules is an important approach in facilitating hit exploration in the early stage of drug discovery. Although information on millions of compounds and their bioactivities is freely available to the public, it is very challenging to infer a meaningful and novel SAR from that information. Research discussed in the present paper employed a bioactivity-centered clustering approach to group 843,845 non-inactive compounds stored in PubChem according to both structural similarity and bioactivity similarity, with the aim of mining bioactivity data in PubChem for useful SAR information. The compounds were clustered in three bioactivity similarity contexts: (1) non-inactive in a given bioassay, (2) non-inactive against a given protein, and (3) non-inactive against proteins involved in a given pathway. In each context, these small molecules were clustered according to their two-dimensional (2-D) and three-dimensional (3-D) structural similarities. The resulting 18 million clusters, named "PubChem SAR clusters", were delivered in such a way that each cluster contains a group of small molecules similar to each other in both structure and bioactivity. The PubChem SAR clusters, pre-computed using publicly available bioactivity information, make it possible to quickly navigate and narrow down the compounds of interest. Each SAR cluster can be a useful resource in developing a meaningful SAR or enable one to design or expand compound libraries from the cluster. It can also help to predict the potential therapeutic effects and pharmacological actions of less-known compounds from those of well-known compounds (i.e., drugs) in the same cluster. [Figure not available: see fulltext.] JF - Journal of Cheminformatics AU - Kim, Sunghwan AU - Han, Lianyi AU - Yu, Bo AU - Haehnke, Volker D AU - Bolton, Evan E AU - Bryant, Stephen H AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD, 20894, USA, bolton@ncbi.nlm.nih.gov Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1 EP - 22 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 7 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Drug discovery KW - Data processing KW - Informatics KW - Structure-activity relationships KW - Drugs KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837306032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cheminformatics&rft.atitle=PubChem+structure-activity+relationship+%28SAR%29+clusters&rft.au=Kim%2C+Sunghwan%3BHan%2C+Lianyi%3BYu%2C+Bo%3BHaehnke%2C+Volker+D%3BBolton%2C+Evan+E%3BBryant%2C+Stephen+H&rft.aulast=Kim&rft.aufirst=Sunghwan&rft.date=2015-12-01&rft.volume=7&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cheminformatics&rft.issn=1758-2946&rft_id=info:doi/10.1186%2Fs13321-015-0070-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 59 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Drug discovery; Data processing; Informatics; Drugs; Structure-activity relationships DO - http://dx.doi.org/10.1186/s13321-015-0070-x ER - TY - JOUR T1 - Genomic Evidence Reveals Numerous Salmonella enterica Serovar Newport Reintroduction Events in Suwannee Watershed Irrigation Ponds AN - 1832246156; PQ0002380989 AB - Our previous work indicated a predominance (56.8%) of Salmonella enterica serovar Newport among isolates recovered from irrigation ponds used in produce farms over a 2-year period (B. Li et al., Appl Environ Microbiol 80:6355-6365, http://dx.doi.org/10.1128/AEM.02063-14). This observation provided a valuable set of metrics to explore an underaddressed issue of environmental survival of Salmonella by DNA microarray. Microarray analysis correctly identified all the isolates (n = 53) and differentiated the S. Newport isolates into two phylogenetic lineages (S. Newport II and S. Newport III). Serovar distribution analysis showed no instances where the same serovar was recovered from a pond for more than a month. Furthermore, during the study, numerous isolates with an indistinguishable genotype were recovered from different ponds as far as 180 km apart for time intervals as long as 2 years. Although isolates within either lineage were phylogenetically related as determined by microarray analysis, subtle genotypic differences were detected within the lineages, suggesting that isolates in either lineage could have come from several unique hosts. For example, strains in four different subgroups (A, B, C, and D) possessed an indistinguishable genotype within their subgroups as measured by gene differences, suggesting that strains in each subgroup shared a common host. Based on this comparative genomic evidence and the spatial and temporal factors, we speculated that the presence of Salmonella in the ponds was likely due to numerous punctuated reintroduction events associated with several different but common hosts in the environment. These findings may have implications for the development of strategies for efficient and safe irrigation to minimize the risk of Salmonella outbreaks associated with fresh produce. JF - Applied and Environmental Microbiology AU - Li, Baoguang AU - Jackson, Scott A AU - Gangiredla, Jayanthi AU - Wang, Weimin AU - Liu, Huanli AU - Tall, Ben D AU - Beaubrun, Junia Jean-Gilles AU - Jay-Russell, Michele AU - Vellidis, George AU - Elkins, Christopher A AD - << + $0, baoguang.li@fda.hhs.gov. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 8243 EP - 8253 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 24 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Phylogeny KW - Reintroduction KW - Farms KW - Irrigation KW - Survival KW - Genotypes KW - Watersheds KW - DNA microarrays KW - Ponds KW - Salmonella enterica KW - genomics KW - Salmonella KW - A 01450:Environmental Pollution & Waste Treatment KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832246156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Genomic+Evidence+Reveals+Numerous+Salmonella+enterica+Serovar+Newport+Reintroduction+Events+in+Suwannee+Watershed+Irrigation+Ponds&rft.au=Li%2C+Baoguang%3BJackson%2C+Scott+A%3BGangiredla%2C+Jayanthi%3BWang%2C+Weimin%3BLiu%2C+Huanli%3BTall%2C+Ben+D%3BBeaubrun%2C+Junia+Jean-Gilles%3BJay-Russell%2C+Michele%3BVellidis%2C+George%3BElkins%2C+Christopher+A&rft.aulast=Li&rft.aufirst=Baoguang&rft.date=2015-12-01&rft.volume=81&rft.issue=24&rft.spage=8243&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02179-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 48 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Reintroduction; Phylogeny; Farms; Irrigation; Survival; Genotypes; genomics; Watersheds; DNA microarrays; Ponds; Salmonella enterica; Salmonella DO - http://dx.doi.org/10.1128/AEM.02179-15 ER - TY - JOUR T1 - Application of Metagenomic Sequencing to Food Safety: Detection of Shiga Toxin-Producing Escherichia coli on Fresh Bagged Spinach AN - 1832244746; PQ0002380977 AB - Culture-independent diagnostics reduce the reliance on traditional (and slower) culture-based methodologies. Here we capitalize on advances in next-generation sequencing (NGS) to apply this approach to food pathogen detection utilizing NGS as an analytical tool. In this study, spiking spinach with Shiga toxin-producing Escherichia coli (STEC) following an established FDA culture-based protocol was used in conjunction with shotgun metagenomic sequencing to determine the limits of detection, sensitivity, and specificity levels and to obtain information on the microbiology of the protocol. We show that an expected level of contamination ( similar to 10 CFU/100 g) could be adequately detected (including key virulence determinants and strain-level specificity) within 8 h of enrichment at a sequencing depth of 10,000,000 reads. We also rationalize the relative benefit of static versus shaking culture conditions and the addition of selected antimicrobial agents, thereby validating the long-standing culture-based parameters behind such protocols. Moreover, the shotgun metagenomic approach was informative regarding the dynamics of microbial communities during the enrichment process, including initial surveys of the microbial loads associated with bagged spinach; the microbes found included key genera such as Pseudomonas, Pantoea, and Exiguobacterium. Collectively, our metagenomic study highlights and considers various parameters required for transitioning to such sequencing-based diagnostics for food safety and the potential to develop better enrichment processes in a high-throughput manner not previously possible. Future studies will investigate new species-specific DNA signature target regimens, rational design of medium components in concert with judicious use of additives, such as antibiotics, and alterations in the sample processing protocol to enhance detection. JF - Applied and Environmental Microbiology AU - Leonard, Susan R AU - Mammel, Mark K AU - Lacher, David W AU - Elkins, Christopher A Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 8183 EP - 8191 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 23 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Food KW - Pseudomonas KW - Antibiotics KW - Pathogens KW - Food contamination KW - Firing pattern KW - Antimicrobial agents KW - Virulence KW - Exiguobacterium KW - Colony-forming cells KW - Escherichia coli KW - DNA KW - Spinacia oleracea KW - A 01330:Food Microbiology KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832244746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Application+of+Metagenomic+Sequencing+to+Food+Safety%3A+Detection+of+Shiga+Toxin-Producing+Escherichia+coli+on+Fresh+Bagged+Spinach&rft.au=Leonard%2C+Susan+R%3BMammel%2C+Mark+K%3BLacher%2C+David+W%3BElkins%2C+Christopher+A&rft.aulast=Leonard&rft.aufirst=Susan&rft.date=2015-12-01&rft.volume=81&rft.issue=23&rft.spage=8183&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02601-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Number of references - 24 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Virulence; Colony-forming cells; Food; DNA; Antibiotics; Pathogens; Food contamination; Firing pattern; Antimicrobial agents; Exiguobacterium; Escherichia coli; Pseudomonas; Spinacia oleracea DO - http://dx.doi.org/10.1128/AEM.02601-15 ER - TY - JOUR T1 - Changes in sexual risk behavior among MSM participating in a research cohort in coastal Kenya AN - 1808696858; PQ0003241920 AB - Objective: To describe changes in sexual risk behavior among Kenyan MSM who received regular risk reduction counseling (RRC). Design: Data were derived from two cohorts of HIV-1-negative and HIV-1-positive MSM in Kenya. Behavioral data were collected at enrollment and at monthly or quarterly scheduled follow-up visits. At each visit, RRC was provided to all men and HIV-1 testing to seronegative men. Methods: Random effects logistic and Poisson regression models with time since study entry as main variable of interest were used to evaluate changes in number of sex partners and unprotected sex in the past week, and insertive, receptive, and unprotected anal intercourse in the past 3 months. Analyses were adjusted for HIV-1-status, calendar year of follow-up, and several baseline characteristics. Trends over follow-up time were allowed to differ by HIV-1-status. Men were censored when they seroconverted for HIV. Results: Number of regular and casual sex partners and unprotected anal intercourse decreased in both HIV-1-negative and HIV-1-positive men. Unprotected sex with both regular and casual sex partners decreased more strongly early in follow-up in HIV-1-positive men than in HIV-1-negative men. Decreases in insertive anal intercourse were found for HIV-1-positive men only, whereas decreases in receptive anal intercourse were found for HIV-1-negative men only. Conclusion: : MSM who were regularly exposed to RRC showed some reductions in sexual risk behavior, but it is uncertain if these reductions are sustained over time. As HIV-1 incidences in Kenyan MSM are very high, RRC should be supported by comprehensive biomedical interventions. JF - AIDS AU - Moller, Lisanne M AU - Stolte, Ineke G AU - Geskus, Ronald B AU - Okuku, Haile Selassie AU - Wahome, Elizabeth AU - Price, Matt A AU - Prins, Maria AU - Graham, Susan M AU - Sanders, Eduard J AD - Department of Infectious Diseases Research and Prevention, Public Health Service Amsterdam, the Netherlands, istolte@ggd.amsterdam.nl Y1 - 2015/12// PY - 2015 DA - December 2015 SP - S211 EP - S219 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 29 SN - 0269-9370, 0269-9370 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - HIV-1 KW - Kenya KW - MSM KW - risk reduction counseling KW - sexual behavior KW - Acquired immune deficiency syndrome KW - Data processing KW - Intervention KW - Anal sex KW - Risk reduction KW - Sexual behavior KW - Models KW - Human immunodeficiency virus KW - Human immunodeficiency virus 1 KW - Regression analysis KW - Sex KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808696858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Changes+in+sexual+risk+behavior+among+MSM+participating+in+a+research+cohort+in+coastal+Kenya&rft.au=Moller%2C+Lisanne+M%3BStolte%2C+Ineke+G%3BGeskus%2C+Ronald+B%3BOkuku%2C+Haile+Selassie%3BWahome%2C+Elizabeth%3BPrice%2C+Matt+A%3BPrins%2C+Maria%3BGraham%2C+Susan+M%3BSanders%2C+Eduard+J&rft.aulast=Moller&rft.aufirst=Lisanne&rft.date=2015-12-01&rft.volume=29&rft.issue=&rft.spage=S211&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0000000000000890 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-04 N1 - SubjectsTermNotLitGenreText - Data processing; Regression analysis; Sexual behavior; Models; Sex; Acquired immune deficiency syndrome; Human immunodeficiency virus; Intervention; Risk reduction; Anal sex; Human immunodeficiency virus 1; Kenya DO - http://dx.doi.org/10.1097/QAD.0000000000000890 ER - TY - JOUR T1 - FDA Approval Summary: Lenvatinib for Progressive, Radio-iodine-Refractory Differentiated Thyroid Cancer AN - 1808631884; PQ0003454960 AB - The FDA approved lenvatinib (Lenvima, Eisai Inc.) for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory (RAI-refractory) differentiated thyroid cancer (DTC). In an international, multicenter, double-blinded, placebo-controlled trial (E7080-G000-303), 392 patients with locally recurrent or metastatic RAI-refractory DTC and radiographic evidence of disease progression within 12 months prior to randomization were randomly allocated (2:1) to receive either lenvatinib 24 mg orally per day (n = 261) or matching placebo (n = 131) with the option for patients on the placebo arm to receive lenvatinib following independent radiologic confirmation of disease progression. A statistically significant prolongation of progression-free survival (PFS) as determined by independent radiology review was demonstrated [HR, 0.21; 95% confidence interval (CI), 0.16-0.28; P < 0.001, stratified log-rank test], with an estimated median PFS of 18.3 months (95% CI, 15.1, NR) in the lenvatinib arm and 3.6 months (95% CI, 2.2-3.7) in the placebo arm. The most common adverse reactions, in order of decreasing frequency, observed in the lenvatinib-treated patients were hypertension, fatigue, diarrhea, arthralgia/myalgia, decreased appetite, decreased weight, nausea, stomatitis, headache, vomiting, proteinuria, palmar-plantar erythrodysesthesia syndrome, abdominal pain, and dysphonia. Adverse reactions led to dose reductions in 68% of patients receiving lenvatinib at the 24 mg dose and 18% of patients discontinued lenvatinib for adverse reactions leading to residual uncertainty regarding the optimal dose of lenvatinib. Clin Cancer Res; 21(23); 5205-8. copyright 2015 AACR. JF - Clinical Cancer Research AU - Nair, Abhilasha AU - Lemery, Steven J AU - Yang, Jun AU - Marathe, Anshu AU - Zhao, Liang AU - Zhao, Hong AU - Jiang, Xiaoping AU - He, Kun AU - Ladouceur, Gaetan AU - Mitra, Amit K AU - Zhou, Liang AU - Fox, Emily AU - Aungst, Stephanie AU - Helms, Whitney AU - Keegan, Patricia AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, Abhilasha.Nair@fda.hhs.gov Y1 - 2015/12/01/ PY - 2015 DA - 2015 Dec 01 SP - 5205 EP - 5208 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 21 IS - 23 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Fatigue KW - Vomiting KW - Diarrhea KW - Stomatitis KW - Statistical analysis KW - Survival KW - Pain KW - Radiology KW - Appetite KW - Clinical trials KW - Metastases KW - Proteinuria KW - Headache KW - thyroid cancer KW - Nausea KW - Myalgia KW - Arthralgia KW - Side effects KW - Hypertension KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808631884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=FDA+Approval+Summary%3A+Lenvatinib+for+Progressive%2C+Radio-iodine-Refractory+Differentiated+Thyroid+Cancer&rft.au=Nair%2C+Abhilasha%3BLemery%2C+Steven+J%3BYang%2C+Jun%3BMarathe%2C+Anshu%3BZhao%2C+Liang%3BZhao%2C+Hong%3BJiang%2C+Xiaoping%3BHe%2C+Kun%3BLadouceur%2C+Gaetan%3BMitra%2C+Amit+K%3BZhou%2C+Liang%3BFox%2C+Emily%3BAungst%2C+Stephanie%3BHelms%2C+Whitney%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Nair&rft.aufirst=Abhilasha&rft.date=2015-12-01&rft.volume=21&rft.issue=23&rft.spage=5205&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-1377 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Diarrhea; Vomiting; Fatigue; Stomatitis; Statistical analysis; Survival; Pain; Appetite; Radiology; Clinical trials; Metastases; Proteinuria; thyroid cancer; Headache; Nausea; Arthralgia; Myalgia; Side effects; Hypertension DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-1377 ER - TY - JOUR T1 - Sequence-independent amplification coupled with DNA microarray analysis for detection and genotyping of noroviruses AN - 1780519089; PQ0002844682 AB - Noroviruses (NoVs) have high levels of genetic sequence diversities, which lead to difficulties in designing robust universal primers to efficiently amplify specific viral genomes for molecular analysis. We here described the practicality of sequence-independent amplification combined with DNA microarray analysis for simultaneous detection and genotyping of human NoVs in fecal specimens. We showed that single primer isothermal linear amplification (Ribo-SPIA) of genogroup I (GI) and genogroup II (GII) NoVs could be run through the same amplification protocol without the need to design and use any virus-specific primers. Related virus could be subtyped by the unique pattern of hybridization with the amplified product to the microarray. By testing 22 clinical fecal specimens obtained from acute gastroenteritis cases as blinded samples, 2 were GI positive and 18 were GII positive as well as 2 negative for NoVs. A NoV GII positive specimen was also identified as having co-occurrence of hepatitis A virus. The study showed that there was 100 % concordance for positive NoV detection at genogroup level between the results of Ribo-SPIA/microarray and the phylogenetic analysis of viral sequences of the capsid gene. In addition, 85 % genotype agreement was observed for the new assay compared to the results of phylogenetic analysis. JF - AMB Express AU - Hu, Yuan AU - Yan, Huijun AU - Mammel, Mark AU - Chen, Haifeng AD - Northeast Region Laboratory, Office of Regulatory Affairs, Food and Drug Administration, Jamaica, NY, USA, haifeng.chen@fda.hhs.gov Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1 EP - 9 PB - Springer Science & Business Media, Berlin/Heidelberg VL - 5 IS - 1 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Phylogeny KW - Genomes KW - Capsids KW - Genotyping KW - Hepatitis A virus KW - Genetic diversity KW - Norovirus KW - Primers KW - Genotypes KW - Gastroenteritis KW - DNA microarrays KW - W 30910:Imaging KW - N 14810:Methods KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1780519089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AMB+Express&rft.atitle=Sequence-independent+amplification+coupled+with+DNA+microarray+analysis+for+detection+and+genotyping+of+noroviruses&rft.au=Hu%2C+Yuan%3BYan%2C+Huijun%3BMammel%2C+Mark%3BChen%2C+Haifeng&rft.aulast=Hu&rft.aufirst=Yuan&rft.date=2015-12-01&rft.volume=5&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=AMB+Express&rft.issn=2191-0855&rft_id=info:doi/10.1186%2Fs13568-015-0156-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Number of references - 26 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Capsids; Genomes; Phylogeny; Genotyping; Genetic diversity; Primers; Genotypes; Gastroenteritis; DNA microarrays; Hepatitis A virus; Norovirus DO - http://dx.doi.org/10.1186/s13568-015-0156-x ER - TY - JOUR T1 - Respiratory morbidity in a coffee processing workplace with sentinel obliterative bronchiolitis cases AN - 1776670914; PQ0002754788 AB - Rationale Obliterative bronchiolitis in former coffee workers prompted a cross-sectional study of current workers. Diacetyl and 2,3-pentanedione levels were highest in areas for flavoring and grinding/packaging unflavored coffee. Methods We interviewed 75 (88%) workers, measured lung function, and created exposure groups based on work history. We calculated standardized morbidity ratios (SMRs) for symptoms and spirometric abnormalities. We examined health outcomes by exposure groups. Results SMRs were elevated 1.6-fold for dyspnea and 2.7-fold for obstruction. The exposure group working in both coffee flavoring and grinding/packaging of unflavored coffee areas had significantly lower mean ratio of forced expiratory volume in 1s to forced vital capacity and percent predicted mid-expiratory flow than workers without such exposure. Conclusion Current workers have occupational lung morbidity associated with high diacetyl and 2,3-pentanedione exposures, which were not limited to flavoring areas. Am. J. Ind. Med. 58:1235-1245, 2015. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Bailey, Rachel L AU - Cox-Ganser, Jean M AU - Duling, Matthew G AU - LeBouf, Ryan F AU - Martin, Stephen B AU - Bledsoe, Toni A AU - Green, Brett J AU - Kreiss, Kathleen AD - Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Respiratory Health Division, Field Studies Branch, Morgantown, WV. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1235 EP - 1245 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 12 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Coffee KW - Historical account KW - USA KW - Lung KW - Standards KW - Respiratory function KW - Occupational exposure KW - Morbidity KW - Packaging KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1776670914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Respiratory+morbidity+in+a+coffee+processing+workplace+with+sentinel+obliterative+bronchiolitis+cases&rft.au=Bailey%2C+Rachel+L%3BCox-Ganser%2C+Jean+M%3BDuling%2C+Matthew+G%3BLeBouf%2C+Ryan+F%3BMartin%2C+Stephen+B%3BBledsoe%2C+Toni+A%3BGreen%2C+Brett+J%3BKreiss%2C+Kathleen&rft.aulast=Bailey&rft.aufirst=Rachel&rft.date=2015-12-01&rft.volume=58&rft.issue=12&rft.spage=1235&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22533 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Coffee; Historical account; Lung; Standards; Respiratory function; Morbidity; Occupational exposure; Packaging; USA DO - http://dx.doi.org/10.1002/ajim.22533 ER - TY - JOUR T1 - Human kidney proximal tubule cells are vulnerable to the effects of Rauwolfia serpentina AN - 1768570832; PQ0002663142 AB - Rauwolfia serpentina (or Snake root plant) is a botanical dietary supplement marketed in the USA for maintaining blood pressure. Very few studies have addressed the safety of this herb, despite its wide availability to consumers. Its reported pleiotropic effects underscore the necessity for evaluating its safety. We used a human kidney cell line to investigate the possible negative effects of R. serpentina on the renal system in vitro, with a specific focus on the renal proximal tubules. We evaluated cellular and mitochondrial toxicity, along with a variety of other kidney-specific toxicology biomarkers. We found that R. serpentina was capable of producing highly detrimental effects in our in vitro renal cell system. These results suggest more studies are needed to investigate the safety of this dietary supplement in both kidney and other target organ systems. JF - Cell Biology and Toxicology AU - Mossoba, Miriam E AU - Flynn, Thomas J AU - Vohra, Sanah AU - Wiesenfeld, Paddy L AU - Sprando, Robert L AD - Center for Food Safety and Applied Nutrition (CFSAN), Office of Applied Research and Safety Assessment (OARSA), Division of Toxicology (DOT), Neurotoxicology and in vitro Toxicology Branch (NIVTB), U.S. Food and Drug Administration (US FDA), 8301 Muirkirk Rd., Laurel, MD, 20708, USA, miriam.mossoba@fda.hhs.gov Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 285 EP - 293 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 31 IS - 6 SN - 0742-2091, 0742-2091 KW - Toxicology Abstracts KW - Proximal tubules KW - Dietary supplements KW - Kidney KW - Mitochondria KW - Roots KW - Consumers KW - Toxicity KW - Herbs KW - biomarkers KW - Blood pressure KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768570832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Biology+and+Toxicology&rft.atitle=Human+kidney+proximal+tubule+cells+are+vulnerable+to+the+effects+of+Rauwolfia+serpentina&rft.au=Mossoba%2C+Miriam+E%3BFlynn%2C+Thomas+J%3BVohra%2C+Sanah%3BWiesenfeld%2C+Paddy+L%3BSprando%2C+Robert+L&rft.aulast=Mossoba&rft.aufirst=Miriam&rft.date=2015-12-01&rft.volume=31&rft.issue=6&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Cell+Biology+and+Toxicology&rft.issn=07422091&rft_id=info:doi/10.1007%2Fs10565-016-9311-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 41 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Proximal tubules; Dietary supplements; Kidney; Roots; Mitochondria; Consumers; Toxicity; biomarkers; Herbs; Blood pressure DO - http://dx.doi.org/10.1007/s10565-016-9311-7 ER - TY - JOUR T1 - Gene therapy for cancer: regulatory considerations for approval AN - 1765959029; PQ0002595202 AB - The rapidly changing field of gene therapy promises a number of innovative treatments for cancer patients. Advances in genetic modification of cancer and immune cells and the use of oncolytic viruses and bacteria have led to numerous clinical trials for cancer therapy, with several progressing to late-stage product development. At the time of this writing, no gene therapy product has been approved by the United States Food and Drug Administration (FDA). Some of the key scientific and regulatory issues include understanding of gene transfer vector biology, safety of vectors in vitro and in animal models, optimum gene transfer, long-term persistence or integration in the host, shedding of a virus and ability to maintain transgene expression in vivo for a desired period of time. Because of the biological complexity of these products, the FDA encourages a flexible, data-driven approach for preclinical safety testing programs. The clinical trial design should be based on the unique features of gene therapy products, and should ensure the safety of enrolled subjects. This article focuses on regulatory considerations for gene therapy product development and also discusses guidance documents that have been published by the FDA. JF - Cancer Gene Therapy AU - Husain, S R AU - Han, J AU - Au, P AU - Shannon, K AU - Puri, R K AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration, Silver Spring, MD, USA Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 554 EP - 563 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 22 IS - 12 SN - 0929-1903, 0929-1903 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Expression vectors KW - Integration KW - Gene therapy KW - Transgenes KW - Animal models KW - Oncolysis KW - Clinical trials KW - Immunosuppressive agents KW - Cancer KW - W 30905:Medical Applications KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765959029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Gene+Therapy&rft.atitle=Gene+therapy+for+cancer%3A+regulatory+considerations+for+approval&rft.au=Husain%2C+S+R%3BHan%2C+J%3BAu%2C+P%3BShannon%2C+K%3BPuri%2C+R+K&rft.aulast=Husain&rft.aufirst=S&rft.date=2015-12-01&rft.volume=22&rft.issue=12&rft.spage=554&rft.isbn=&rft.btitle=&rft.title=Cancer+Gene+Therapy&rft.issn=09291903&rft_id=info:doi/10.1038%2Fcgt.2015.58 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Expression vectors; Integration; Gene therapy; Transgenes; Animal models; Oncolysis; Immunosuppressive agents; Clinical trials; Cancer DO - http://dx.doi.org/10.1038/cgt.2015.58 ER - TY - JOUR T1 - An entomological review of invasive mosquitoes in Europe AN - 1762382326; PQ0002458970 AB - Among the invasive mosquitoes registered all over the world, Aedes species are particularly frequent and important. As several of them are potential vectors of disease, they present significant health concerns for 21st century Europe. Five species have established in mainland Europe, with two (Aedes albopictus and Aedes japonicus) becoming widespread and two (Ae. albopictus and Aedes aegypti) implicated in disease transmission to humans in Europe. The routes of importation and spread are often enigmatic, the ability to adapt to local environments and climates are rapid, and the biting nuisance and vector potential are both an ecomonic and public health concern. Europeans are used to cases of dengue and chikungunya in travellers returning from the tropics, but the threat to health and tourism in mainland Europe is substantive. Coupled to that are the emerging issues in the European overseas territorities and this paper is the first to consider the impacts in the remoter outposts of Europe. If entomologists and public health authorities are to address the spread of these mosquitoes and mitigate their health risks they must first be prepared to share information to better understand their biology and ecology, and share data on their distribution and control successes. This paper focusses in greater detail on the entomological and ecological aspects of these mosquitoes to assist with the risk assessment process, bringing together a large amount of information gathered through the ECDC VBORNET project. JF - Bulletin of Entomological Research AU - Medlock, J M AU - Hansford, K M AU - Versteirt, V AU - Cull, B AU - Kampen, H AU - Fontenille, D AU - Hendrickx, G AU - Zeller, H AU - Van Bortel, W AU - Schaffner, F AD - Medical Entomology Group, MRA/BS, Emergency Response Department, Public Health England, Porton Down, Salisbury, UK, jolyon.medlock@phe.gov.uk Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 637 EP - 663 PB - CAB International, Wallingford Oxon OX10 8DE United Kingdom VL - 105 IS - 6 SN - 0007-4853, 0007-4853 KW - ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality; Entomology Abstracts KW - Risk assessment KW - Tourism KW - Aedes aegypti KW - Data processing KW - Climate KW - Travellers KW - Vectors KW - Pest control KW - Hosts KW - Importation KW - Aedes albopictus KW - Public health KW - Disease transmission KW - Entomologists KW - Biting KW - Dengue KW - ANE, Europe KW - Aquatic insects KW - Environment management KW - Dispersion KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762382326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+Entomological+Research&rft.atitle=An+entomological+review+of+invasive+mosquitoes+in+Europe&rft.au=Medlock%2C+J+M%3BHansford%2C+K+M%3BVersteirt%2C+V%3BCull%2C+B%3BKampen%2C+H%3BFontenille%2C+D%3BHendrickx%2C+G%3BZeller%2C+H%3BVan+Bortel%2C+W%3BSchaffner%2C+F&rft.aulast=Medlock&rft.aufirst=J&rft.date=2015-12-01&rft.volume=105&rft.issue=6&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+Entomological+Research&rft.issn=00074853&rft_id=info:doi/10.1017%2FS0007485315000103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 253 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Entomologists; Climate; Pest control; Hosts; Environment management; Aquatic insects; Dispersion; Disease transmission; Public health; Tourism; Risk assessment; Data processing; Biting; Dengue; Travellers; Vectors; Importation; Aedes aegypti; Aedes albopictus; ANE, Europe DO - http://dx.doi.org/10.1017/S0007485315000103 ER - TY - JOUR T1 - Internet-based remote health self-checker symptom data as an adjuvant to a national syndromic surveillance system AN - 1762380898; PQ0002459157 AB - Syndromic surveillance is an innovative surveillance tool used to support national surveillance programmes. Recent advances in the use of internet-based health data have demonstrated the potential usefulness of these health data; however, there have been limited studies comparing these innovative health data to existing established syndromic surveillance systems. We conducted a retrospective observational study to assess the usefulness of a national internet-based 'symptom checker' service for use as a syndromic surveillance system. NHS Direct online data were extracted for 1 August 2012 to 1 July 2013; a time-series analysis on the symptom categories self-reported by online users was undertaken and compared to existing telehealth syndromic data. There were 3.37 million online users of the internet-based self-checker compared to 1.43 million callers to the telephone triage health service. There was a good correlation between the online and telephone triage data for a number of syndromic indicators including cold/flu, difficulty breathing and eye problems; however, online data appeared to provide additional early warning over telephone triage health data. This assessment has illustrated some potential benefit of using internet-based symptom-checker data and provides the basis for further investigating how these data can be incorporated into national syndromic surveillance programmes. JF - Epidemiology and Infection AU - Elliot, A J AU - Kara, E O AU - Loveridge, P AU - Bawa, Z AU - Morbey, R A AU - Moth, M AU - Large, S AU - Smith, Ge AD - Real-time Syndromic Surveillance Team, Public Health England, Birmingham, UK, alex.elliot@phe.gov.uk Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 3416 EP - 3422 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 16 SN - 0950-2688, 0950-2688 KW - Health & Safety Science Abstracts KW - Eye KW - Time series analysis KW - Innovations KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762380898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Internet-based+remote+health+self-checker+symptom+data+as+an+adjuvant+to+a+national+syndromic+surveillance+system&rft.au=Elliot%2C+A+J%3BKara%2C+E+O%3BLoveridge%2C+P%3BBawa%2C+Z%3BMorbey%2C+R+A%3BMoth%2C+M%3BLarge%2C+S%3BSmith%2C+Ge&rft.aulast=Elliot&rft.aufirst=A&rft.date=2015-12-01&rft.volume=143&rft.issue=16&rft.spage=3416&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268815000503 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 15 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Eye; Time series analysis; Innovations DO - http://dx.doi.org/10.1017/S0950268815000503 ER - TY - JOUR T1 - Investigation of a measles outbreak in Zimbabwe, 2010: potential of a point of care test to replace laboratory confirmation of suspected cases AN - 1762380546; PQ0002459161 AB - Blood and oral fluid (OF) samples were collected from 103 suspected measles cases between February and November 2010 during a nationwide measles outbreak in Zimbabwe. Siemens measles IgM enzyme immunoassay (EIA) on serum, Microimmune measles IgM capture EIA on OF, real-time haemagglutinin (H) gene PCR and nested nucleocapsid (N) gene PCR on OF were performed, confirming 75 measles cases. These samples were then used to evaluate a newly developed point of care test (POCT) for measles and determine its potential for identifying measles cases in outbreaks. After performing POCTs on OF samples, nucleic acid was extracted from the used test strips and the measles H and N genes amplified by RT-PCR. The sensitivity, specificity, positive and negative predictive values of the POCT for IgM in OF was 75.0% [95% confidence interval (CI) 63.4-84.5], 96.2% (95% CI 80.4-99.9), 98.2% (95% CI 90.3-100) and 58.1% (95% CI 42.1-73.0), respectively. The N gene sequences showed high level of agreement between original OF and corresponding POCT strips. Measles genotype B3 was identified in all cases. We conclude that the measles POCT has the potential to be used, at the point of contact, in outbreak situations and provide molecular characterization of the virus at a later date. JF - Epidemiology and Infection AU - Shonhai, A AU - Warrener, L AU - MANGWANYA, D AU - SLIBINSKAS, R AU - Brown, K AU - Brown, D AU - Featherstone, D AU - Samuel, D AD - Zimbabwe National Virology Laboratory, Department of Medical Microbiology, College of Health Science, University of Zimbabwe, Zimbabwe, dhan.samuel@phe.gov.uk Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 3442 EP - 3450 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 16 SN - 0950-2688, 0950-2688 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Sensitivity KW - Environmental impact assessment KW - Measles KW - Hemagglutinins KW - Enzymes KW - H gene KW - Genotypes KW - Enzyme immunoassay KW - Blood KW - nucleic acids KW - N gene KW - Nucleocapsids KW - Polymerase chain reaction KW - Outbreaks KW - Immunoassays KW - oral fluids KW - Nucleic acids KW - Immunoglobulin M KW - Zimbabwe KW - H 12000:Epidemiology and Public Health KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762380546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Investigation+of+a+measles+outbreak+in+Zimbabwe%2C+2010%3A+potential+of+a+point+of+care+test+to+replace+laboratory+confirmation+of+suspected+cases&rft.au=Shonhai%2C+A%3BWarrener%2C+L%3BMANGWANYA%2C+D%3BSLIBINSKAS%2C+R%3BBrown%2C+K%3BBrown%2C+D%3BFeatherstone%2C+D%3BSamuel%2C+D&rft.aulast=Shonhai&rft.aufirst=A&rft.date=2015-12-01&rft.volume=143&rft.issue=16&rft.spage=3442&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268815000540 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 17 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Blood; nucleic acids; N gene; Measles; Hemagglutinins; Nucleocapsids; Polymerase chain reaction; Genotypes; H gene; oral fluids; Immunoglobulin M; Enzyme immunoassay; Sensitivity; Environmental impact assessment; Enzymes; Outbreaks; Immunoassays; Nucleic acids; Zimbabwe DO - http://dx.doi.org/10.1017/S0950268815000540 ER - TY - JOUR T1 - Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure AN - 1762375162; PQ0002492810 AB - Acrylamide is a contaminant in baked and fried starchy foods, roasted coffee, and cigarette smoke. Previously we reported that acrylamide is a multi-organ carcinogen in B6C3F1 mice and F344/N rats, and hypothesized that acrylamide is activated to an ultimate carcinogen through metabolism to the epoxide glycidamide. We have now examined the carcinogenic effects of glycidamide administered at 0, 0.0875, 0.175, 0.35 and 0.70 mM in drinking water to the same strains of rodents for two years. In male and female mice, there were significant increases in tumors of the Harderian gland, lung, forestomach, and skin. Female mice also had an increased incidence of tumors of the mammary gland and ovary. In male and female rats, there were significant increases in thyroid gland and oral cavity neoplasms and mononuclear cell leukemia. Male rats also had increases in tumors of the epididymis/testes and heart, while female rats demonstrated increases in tumors of the mammary gland, clitoral gland, and forestomach. A similar spectrum of tumors was obtained in mice and rats administered acrylamide. These data indicate that, under the conditions of these bioassays, acrylamide is efficiently metabolized to glycidamide and that the carcinogenic activity of acrylamide is due to its conversion into glycidamide. JF - Food and Chemical Toxicology AU - Beland, Frederick A AU - Olson, Greg R AU - Mendoza, Maria CB AU - Marques, MMatilde AU - Doerge, Daniel R AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 104 EP - 115 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 86 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Acrylamide KW - Glycidamide KW - Tumorigenicity KW - Mice KW - Rats KW - Bioassay KW - ANOVA analysis of variance KW - BMD benchmark dose KW - BMDL lower limit of benchmark dose KW - N3-GA-Ade N3-(2-carbamoyl-2-hydroxyethyl)adenine KW - N7-GA-Gua N7-(2-carbamoyl-2-hydroxyethyl)guanine KW - NCTR National Center for Toxicological Research KW - PWG Pathology Working Group KW - Heart KW - Testes KW - Leukocytes (mononuclear) KW - Epoxides KW - Mammary gland KW - Epididymis KW - Harderian gland KW - Food KW - Thyroid KW - Carcinogens KW - Tumors KW - Oral cavity KW - Carcinogenicity KW - Lung KW - Contaminants KW - Drinking water KW - Metabolism KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762375162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Carcinogenicity+of+glycidamide+in+B6C3F1+mice+and+F344%2FN+rats+from+a+two-year+drinking+water+exposure&rft.au=Beland%2C+Frederick+A%3BOlson%2C+Greg+R%3BMendoza%2C+Maria+CB%3BMarques%2C+MMatilde%3BDoerge%2C+Daniel+R&rft.aulast=Beland&rft.aufirst=Frederick&rft.date=2015-12-01&rft.volume=86&rft.issue=&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2015.09.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Testes; Heart; Leukocytes (mononuclear); Epoxides; Epididymis; Mammary gland; Food; Harderian gland; Thyroid; Tumors; Carcinogens; Oral cavity; Acrylamide; Lung; Carcinogenicity; Drinking water; Contaminants; Metabolism DO - http://dx.doi.org/10.1016/j.fct.2015.09.017 ER - TY - JOUR T1 - Prevalence Analysis and Molecular Characterization of Salmonella at Different Processing Steps in Broiler Slaughter Plants in South Korea. AN - 1760865417; 26523619 AB - In this study, changes in the prevalence of Salmonella during the processing of broiler chicken carcasses were investigated. A total of 1040 fecal swabs and chicken carcasses samples were collected from 2 processing plants at the 4 stages of broiler processing, which included live birds in slaughter line, postevisceration/prewashing, postwashing/prechilling, and postchilling, respectively. The intraspecific biodiversity of the Salmonella isolates was determined using a DiversiLab automated repetitive sequence-based PCR (rep-PCR) system. In both plants, the prevalence of Salmonella increased considerably after evisceration (from 4.6% to 30.8%, P 0.05). The most frequent Salmonella serovar in plant A was Infantis (35.8%), followed by Enteritidis (26.2%) and Montevideo (15.0%), while Montevideo (43.6%) and Enteritidis (35.9%) were most prevalent in plant B. A difference in the rep-PCR banding pattern was found to be related to the processing plant origin and serovar rather than sampling point or sampling day, although there were some exceptional strains. © 2015 Institute of Food Technologists® JF - Journal of food science AU - Park, Hyun-Jung AU - Chon, Jung-Whan AU - Lim, Jong-Soo AU - Seo, Kun-Ho AU - Kim, Young-Jo AU - Heo, Eun-Jeong AU - Wee, Sung-Hwan AU - Sung, Kidon AU - Moon, Jin-San AD - KU Center for Food Safety, College of Veterinary Medicine, Konkuk Univ, Seoul, Republic of Korea. ; Ministry of Food and Drug safety, Cheongju, Republic of Korea. ; Animal and Plant Quarantine Agency, Anyang, Republic of Korea. ; Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, U.S.A. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - M2822 EP - M2826 VL - 80 IS - 12 KW - Index Medicus KW - subtyping KW - poultry processing KW - salmonella KW - contamination KW - Republic of Korea KW - Polymerase Chain Reaction KW - Disinfection KW - Animals KW - Chickens KW - Humans KW - Cold Temperature KW - Serogroup KW - Prevalence KW - Salmonella -- genetics KW - Food Microbiology KW - Abattoirs KW - Salmonella -- growth & development KW - Food Handling KW - Salmonella -- isolation & purification KW - Meat -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1760865417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+science&rft.atitle=Prevalence+Analysis+and+Molecular+Characterization+of+Salmonella+at+Different+Processing+Steps+in+Broiler+Slaughter+Plants+in+South+Korea.&rft.au=Park%2C+Hyun-Jung%3BChon%2C+Jung-Whan%3BLim%2C+Jong-Soo%3BSeo%2C+Kun-Ho%3BKim%2C+Young-Jo%3BHeo%2C+Eun-Jeong%3BWee%2C+Sung-Hwan%3BSung%2C+Kidon%3BMoon%2C+Jin-San&rft.aulast=Park&rft.aufirst=Hyun-Jung&rft.date=2015-12-01&rft.volume=80&rft.issue=12&rft.spage=M2822&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+science&rft.issn=1750-3841&rft_id=info:doi/10.1111%2F1750-3841.13106 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-01 N1 - Date created - 2016-01-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/1750-3841.13106 ER - TY - JOUR T1 - A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. AN - 1747305133; 26552008 AB - The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome (MERS)-CoV underscores the threat of cross-species transmission events leading to outbreaks in humans. Here we examine the disease potential of a SARS-like virus, SHC014-CoV, which is currently circulating in Chinese horseshoe bat populations. Using the SARS-CoV reverse genetics system, we generated and characterized a chimeric virus expressing the spike of bat coronavirus SHC014 in a mouse-adapted SARS-CoV backbone. The results indicate that group 2b viruses encoding the SHC014 spike in a wild-type backbone can efficiently use multiple orthologs of the SARS receptor human angiotensin converting enzyme II (ACE2), replicate efficiently in primary human airway cells and achieve in vitro titers equivalent to epidemic strains of SARS-CoV. Additionally, in vivo experiments demonstrate replication of the chimeric virus in mouse lung with notable pathogenesis. Evaluation of available SARS-based immune-therapeutic and prophylactic modalities revealed poor efficacy; both monoclonal antibody and vaccine approaches failed to neutralize and protect from infection with CoVs using the novel spike protein. On the basis of these findings, we synthetically re-derived an infectious full-length SHC014 recombinant virus and demonstrate robust viral replication both in vitro and in vivo. Our work suggests a potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations. JF - Nature medicine AU - Menachery, Vineet D AU - Yount, Boyd L AU - Debbink, Kari AU - Agnihothram, Sudhakar AU - Gralinski, Lisa E AU - Plante, Jessica A AU - Graham, Rachel L AU - Scobey, Trevor AU - Ge, Xing-Yi AU - Donaldson, Eric F AU - Randell, Scott H AU - Lanzavecchia, Antonio AU - Marasco, Wayne A AU - Shi, Zhengli-Li AU - Baric, Ralph S AD - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. ; National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. ; Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China. ; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. ; Institute for Research in Biomedicine, Bellinzona Institute of Microbiology, Zurich, Switzerland. ; Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1508 EP - 1513 VL - 21 IS - 12 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Viral KW - Index Medicus KW - Virus Replication KW - Phylogeny KW - Epithelial Cells -- virology KW - Animals KW - Epidemics KW - Humans KW - Mice, Inbred BALB C KW - Antibodies, Viral -- immunology KW - Lung -- virology KW - Antibodies, Monoclonal -- immunology KW - Virulence KW - Epithelial Cells -- pathology KW - Neutralization Tests KW - Cell Line KW - Female KW - SARS Virus -- pathogenicity KW - Chiroptera -- virology KW - SARS Virus -- physiology KW - SARS Virus -- immunology KW - Severe Acute Respiratory Syndrome -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1747305133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+medicine&rft.atitle=A+SARS-like+cluster+of+circulating+bat+coronaviruses+shows+potential+for+human+emergence.&rft.au=Menachery%2C+Vineet+D%3BYount%2C+Boyd+L%3BDebbink%2C+Kari%3BAgnihothram%2C+Sudhakar%3BGralinski%2C+Lisa+E%3BPlante%2C+Jessica+A%3BGraham%2C+Rachel+L%3BScobey%2C+Trevor%3BGe%2C+Xing-Yi%3BDonaldson%2C+Eric+F%3BRandell%2C+Scott+H%3BLanzavecchia%2C+Antonio%3BMarasco%2C+Wayne+A%3BShi%2C+Zhengli-Li%3BBaric%2C+Ralph+S&rft.aulast=Menachery&rft.aufirst=Vineet&rft.date=2015-12-01&rft.volume=21&rft.issue=12&rft.spage=1508&rft.isbn=&rft.btitle=&rft.title=Nature+medicine&rft.issn=1546-170X&rft_id=info:doi/10.1038%2Fnm.3985 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-13 N1 - Date created - 2015-12-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Virol. 2014 Dec;88(23):13769-80 [25231316] Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12995-3000 [14569023] Methods Mol Med. 2005;107:183-206 [15492373] Nat Med. 2004 Dec;10(12 Suppl):S88-97 [15577937] J Biol Chem. 2005 Aug 19;280(33):29588-95 [15980414] Vaccine. 2006 Jan 30;24(5):652-61 [16214268] PLoS Pathog. 2007 Jan;3(1):e5 [17222058] J Virol. 2008 Feb;82(4):1899-907 [18077725] J Virol. 2008 Mar;82(5):2274-85 [18094188] J Virol. 2008 Sep;82(17):8721-32 [18579604] PLoS Pathog. 2008 Nov;4(11):e1000197 [18989460] Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19944-9 [19036930] PLoS One. 2010;5(1):e8729 [20090954] J Infect Dis. 2010 Mar 15;201(6):946-55 [20144042] J Virol. 2010 Apr;84(7):3134-46 [19906932] J Virol. 2011 Dec;85(23):12201-15 [21937658] J Virol. 2012 Jan;86(2):884-97 [22072787] J Virol. 2013 Apr;87(7):3885-902 [23365422] JAMA. 2013 Apr 10;309(14):1531-2 [23571595] Nat Rev Microbiol. 2013 Dec;11(12):836-48 [24217413] Antiviral Res. 2013 Oct;100(1):246-54 [23994189] Nature. 2013 Nov 28;503(7477):535-8 [24172901] MBio. 2014;5(2):e00047-14 [24667706] J Virol. 2014 Jun;88(12):7070-82 [24719429] Lancet Infect Dis. 2014 Oct;14(10):992-1000 [25189347] Nature. 2014 Oct 2;514(7520):47-53 [25171469] Erratum In: Nat Med. 2016 Apr;22(4):446 [27050591] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/nm.3985 ER - TY - JOUR T1 - Nanotechnology: History and future. AN - 1737479856; 26614822 JF - Human & experimental toxicology AU - Hulla, J E AU - Sahu, S C AU - Hayes, A W AD - US Army Corps of Engineers, Sacramento, CA, USA. ; Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA. ; Harvard University, Cambridge, MA, USA awallacehayes@comcast.net. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 1318 EP - 1321 VL - 34 IS - 12 KW - Index Medicus KW - History, 21st Century KW - History, 20th Century KW - Risk Assessment KW - Nanotechnology -- history KW - Nanostructures -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737479856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+experimental+toxicology&rft.atitle=Nanotechnology%3A+History+and+future.&rft.au=Hulla%2C+J+E%3BSahu%2C+S+C%3BHayes%2C+A+W&rft.aulast=Hulla&rft.aufirst=J&rft.date=2015-12-01&rft.volume=34&rft.issue=12&rft.spage=1318&rft.isbn=&rft.btitle=&rft.title=Human+%26+experimental+toxicology&rft.issn=1477-0903&rft_id=info:doi/10.1177%2F0960327115603588 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-16 N1 - Date created - 2015-11-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0960327115603588 ER - TY - JOUR T1 - Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward. AN - 1737479648; 26609132 AB - Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking. There is a need for more sensitive and specific biomarkers of neurotoxicity that can help diagnose and predict neurotoxicity that are relevant across animal models and translational from nonclinical to clinical data. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid (CSF) have great potential due to the relative ease of sampling compared with tissues. Increasing evidence supports the potential utility of fluid-based biomarkers of neurotoxicity such as microRNAs, F2-isoprostanes, translocator protein, glial fibrillary acidic protein, ubiquitin C-terminal hydrolase L1, myelin basic protein, microtubule-associated protein-2, and total tau. However, some of these biomarkers such as those in CSF require invasive sampling or are specific to one disease such as Alzheimer's, while others require further validation. Additionally, neuroimaging methodologies, including magnetic resonance imaging, magnetic resonance spectroscopy, and positron emission tomography, may also serve as potential biomarkers and have several advantages including being minimally invasive. The development of biomarkers of neurotoxicity is a goal shared by scientists across academia, government, and industry and is an ideal topic to be addressed via the Health and Environmental Sciences Institute (HESI) framework which provides a forum to collaborate on key challenging scientific topics. Here we utilize the HESI framework to propose a consensus on the relative potential of currently described biomarkers of neurotoxicity to assess utility of the selected biomarkers using a nonclinical model. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Roberts, Ruth A AU - Aschner, Michael AU - Calligaro, David AU - Guilarte, Tomas R AU - Hanig, Joseph P AU - Herr, David W AU - Hudzik, Thomas J AU - Jeromin, Andreas AU - Kallman, Mary J AU - Liachenko, Serguei AU - Lynch, James J AU - Miller, Diane B AU - Moser, Virginia C AU - O'Callaghan, James P AU - Slikker, William AU - Paule, Merle G AD - *ApconiX, BioHub at Alderley Park, Cheshire SK10 4TG, UK; ruth.roberts@apconix.com. ; Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461; ; Eli Lilly & Co., Pharmacology/Toxicology Research Lilly Research Labs, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285; ; §Columbia University, New York, New York 10032; ; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland 20993; ; US EPA, Toxicology Assessment Division, NHEERL, Research Triangle Park, North Carolona 27711; ; AbbVie, Inc., North Chicago, Illinois 60064; ; Quanterix, Inc., Lexington, Massachusetts 02421; ; Covance, Inc., 8211 SciCor Drive, Indianapolis, Indiana 46214; ; **U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas 72079; ; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505; and. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 332 EP - 340 VL - 148 IS - 2 KW - Biomarkers KW - 0 KW - Genetic Markers KW - Index Medicus KW - CSF KW - biomarker KW - neurotoxicity KW - imaging KW - Animals KW - Reproducibility of Results KW - Humans KW - Prognosis KW - Disease Models, Animal KW - Predictive Value of Tests KW - Risk Assessment KW - Neurotoxicity Syndromes -- diagnosis KW - Neurotoxicity Syndromes -- etiology KW - Nervous System -- drug effects KW - Nervous System -- metabolism KW - Biomarkers -- metabolism KW - Translational Medical Research -- methods KW - Toxicology -- methods KW - Neurotoxicity Syndromes -- metabolism KW - Neurotoxicity Syndromes -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737479648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Translational+Biomarkers+of+Neurotoxicity%3A+A+Health+and+Environmental+Sciences+Institute+Perspective+on+the+Way+Forward.&rft.au=Roberts%2C+Ruth+A%3BAschner%2C+Michael%3BCalligaro%2C+David%3BGuilarte%2C+Tomas+R%3BHanig%2C+Joseph+P%3BHerr%2C+David+W%3BHudzik%2C+Thomas+J%3BJeromin%2C+Andreas%3BKallman%2C+Mary+J%3BLiachenko%2C+Serguei%3BLynch%2C+James+J%3BMiller%2C+Diane+B%3BMoser%2C+Virginia+C%3BO%27Callaghan%2C+James+P%3BSlikker%2C+William%3BPaule%2C+Merle+G&rft.aulast=Roberts&rft.aufirst=Ruth&rft.date=2015-12-01&rft.volume=148&rft.issue=2&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv188 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-08 N1 - Date created - 2015-11-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Sci. 2014 Oct;141(2):398-408 [25015659] Toxicol Sci. 2015 Jul;146(1):183-91 [25904105] J Neurotrauma. 2003 Aug;20(8):781-6 [12965056] J Neurotrauma. 2004 Jan;21(1):1-8 [14987460] Neurotoxicology. 2004 Jun;25(4):525-31 [15183007] Science. 1984 Jun 29;224(4656):1451-3 [6610213] Neurobehav Toxicol Teratol. 1986 Sep-Oct;8(5):499-507 [3785511] Clin Exp Neurol. 1986;22:155-64 [3495376] Neuroscience. 1988 Jul;26(1):337-61 [2458546] Biomed Environ Sci. 1991 Jun;4(1-2):197-206 [1910596] Environ Health Perspect. 1992 Nov;98:235-41 [1486855] Occup Med (Lond). 1993 Aug;43(3):149-54 [8400211] J Toxicol Environ Health. 1996 Apr 19;47(6):567-86 [8614024] Expert Opin Drug Saf. 2005 May;4(3):433-42 [15934851] Antioxid Redox Signal. 2006 Jul-Aug;8(7-8):1379-84 [16910785] Dev Neurosci. 2006;28(4-5):327-35 [16943655] J Agromedicine. 2007;12(1):17-25 [18032333] J Neurotrauma. 2007 Dec;24(12):1793-801 [18159990] J Immunol. 2008 Jan 15;180(2):1258-67 [18178866] Pharmacol Ther. 2008 Apr;118(1):1-17 [18374421] Neurosci Biobehav Rev. 2008 Jul;32(5):883-909 [18430470] Neurobiol Dis. 2009 Aug;35(2):117-27 [19426803] Nature. 2009 Sep 10;461(7261):218-23 [19741703] Nature. 2009 Oct 15;461(7266):916-22 [19829371] Dialogues Clin Neurosci. 2009;11(3):305-17 [19877498] J Neurosci Res. 2010 May 15;88(7):1475-84 [20077430] Eur J Neurosci. 2010 Feb;31(4):722-32 [20384815] Nat Rev Drug Discov. 2010 Dec;9(12):971-88 [21119734] Nature. 2011 Jan 13;469(7329):156-7 [21228852] Mt Sinai J Med. 2011 Jan-Feb;78(1):58-77 [21259263] J Neurotrauma. 2011 Jun;28(6):861-70 [21309726] J Neurotrauma. 2012 Jan 1;29(1):162-7 [22022780] Biomark Med. 2012 Feb;6(1):119-29 [22296205] Mult Scler. 2012 May;18(5):552-6 [22492131] Cold Spring Harb Perspect Med. 2012 Sep;2(9):a006221 [22951438] Brain Inj. 2012;26(13-14):1629-35 [22794497] J Cereb Blood Flow Metab. 2013 Jan;33(1):53-8 [22968319] Curr Opin Psychiatry. 2013 May;26(3):276-82 [23493130] Stroke. 2013 Jun;44(6):1739-42 [23559260] J Appl Toxicol. 2013 Sep;33(9):861-8 [23400798] Toxicol Pathol. 2013;41(7):1028-48 [23475559] Proc Natl Acad Sci U S A. 2014 May 20;111(20):7361-6 [24799715] Nat Rev Drug Discov. 2014 Jun;13(6):419-31 [24833294] Neurotox Res. 2014 Aug;26(2):179-89 [24577639] PLoS One. 2014;9(7):e102003 [25025494] Nat Rev Neurol. 2014 Aug;10(8):459-68 [25002107] Toxicol Pathol. 2015 Feb;43(2):198-208 [24777749] Regul Toxicol Pharmacol. 2014 Dec;70(3):641-7 [25265367] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv188 ER - TY - JOUR T1 - Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study. AN - 1737476833; 26209558 AB - Bisphenol A (BPA) is a high volume production chemical and has been identified as an endocrine disruptor, prompting concern that developmental exposure could impact brain development and behavior. Rodent and human studies suggest that early life BPA exposure may result in an anxious, hyperactive phenotype but results are conflicting and data from studies using multiple doses below the no-observed-adverse-effect level are limited. To address this, the present studies were conducted as part of the CLARITY-BPA (Consortium Linking Academic and Regulatory Insights on BPA Toxicity) program. The impact of perinatal BPA exposure (2.5, 25, or 2500 µg/kg body weight (bw)/day) on behaviors related to anxiety and exploratory activity was assessed in juvenile (prepubertal) and adult NCTR Sprague-Dawley rats of both sexes. Ethinyl estradiol (0.5 µg/kg bw/day) was used as a reference estrogen. Exposure spanned gestation and lactation with dams gavaged from gestational day 6 until birth and then the offspring gavaged directly through weaning (n = 12/sex/group). Behavioral assessments included open field, elevated plus maze, and zero maze. Anticipated sex differences in behavior were statistically identified or suggested in most cases. No consistent effects of BPA were observed for any endpoint, in either sex, at either age compared to vehicle controls; however, significant differences between BPA-exposed and ethinyl estradiol-exposed groups were identified for some endpoints. Limitations of this study are discussed and include suboptimal statistical power and low concordance across behavioral tasks. These data do not indicate BPA-related effects on anxiety or exploratory activity in these developmentally exposed rats. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Rebuli, Meghan E AU - Camacho, Luísa AU - Adonay, Maria E AU - Reif, David M AU - Aylor, David L AU - Patisaul, Heather B AD - *Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695; Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695; ; National Center for Toxicological Research, Jefferson, Arkansas 72079; and. ; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695. ; *Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695; Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695. ; *Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina 27695; Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695; hbpatisa@ncsu.edu. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 341 EP - 354 VL - 148 IS - 2 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Phenols KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - plastic KW - behavior KW - anxiety KW - endocrine disruption KW - exploratory activity KW - EDC KW - BPA KW - sexually dimorphic KW - CLARITY KW - brain KW - Maternal Exposure -- adverse effects KW - Animals KW - Age Factors KW - Sex Factors KW - Dose-Response Relationship, Drug KW - Gestational Age KW - Risk Assessment KW - Lactation KW - Pregnancy KW - Rats, Sprague-Dawley KW - Motor Activity -- drug effects KW - Female KW - Male KW - Prenatal Exposure Delayed Effects KW - Neurotoxicity Syndromes -- psychology KW - Endocrine Disruptors -- toxicity KW - Benzhydryl Compounds -- toxicity KW - Behavior, Animal -- drug effects KW - Anxiety -- psychology KW - Anxiety -- chemically induced KW - Exploratory Behavior -- drug effects KW - Neurotoxicity Syndromes -- etiology KW - Phenols -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1737476833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Impact+of+Low-Dose+Oral+Exposure+to+Bisphenol+A+%28BPA%29+on+Juvenile+and+Adult+Rat+Exploratory+and+Anxiety+Behavior%3A+A+CLARITY-BPA+Consortium+Study.&rft.au=Rebuli%2C+Meghan+E%3BCamacho%2C+Lu%C3%ADsa%3BAdonay%2C+Maria+E%3BReif%2C+David+M%3BAylor%2C+David+L%3BPatisaul%2C+Heather+B&rft.aulast=Rebuli&rft.aufirst=Meghan&rft.date=2015-12-01&rft.volume=148&rft.issue=2&rft.spage=341&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv163 LA - English DB - ProQuest Environmental Science Collection N1 - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv163 ER - TY - JOUR T1 - Moraxella catarrhalis-produced nitric oxide has dual roles in pathogenicity and clearance of infection in bacterial-host cell co-cultures. AN - 1735910245; 26537639 AB - In humans, the free radical nitric oxide (NO) is a concentration-dependent multifunctional signaling or toxic molecule that modulates various physiological and pathological processes, and innate immunity against bacterial infections. Because the expression of bacterial genes encoding nitrite reductase (AniA) and NO reductase (NorB) is highly upregulated in biofilms in vitro, it is important to investigate whether bacterial NO-metabolism might subvert host NO signaling and play pathogenic roles during infection. The Moraxella catarrhalis AniA and NorB directly function in production and reduction of NO. Using M. catarrhalis-human bronchial epithelial cell (HBEC) co-cultures, we recently reported AniA/nitrite-dependent cytotoxic effects on HBECs, including altered protein profiles of HBECs and induced HBEC apoptosis, suggesting bacterial nitrite reduction likely dysregulates host cell gene expression. To further clarify whether nitrite reduction-derived NO or nitrite-dependent stimulation of bacterial growth was responsible for adverse effects on HBECs, we monitored bacterial nitrite reduction, levels of NO in co-cultures and resulted dynamic effects on HBEC proliferation and bacterial viability. This study demonstrated that M. catarrhalis nitrite reduction-derived NO was responsible for observed adverse effects on HBECs at mid-to-late stages of infection. More importantly, our data showed that while nitrite promoted bacterial growth and biofilm formation at early hours of infection, nitrite reduction-derived NO was toxic towards M. catarrhalis in maturing biofilms, suggesting nitrite reduction-derived NO might be a possible dualistic mechanism by which M. catarrhalis promotes diseases and spontaneous resolutions. Published by Elsevier Inc. JF - Nitric oxide : biology and chemistry AU - Mocca, Brian AU - Yin, Dandan AU - Gao, Yamei AU - Wang, Wei AD - Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. ; Division of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. ; Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993-0002, USA. Electronic address: wei02.wang@fda.hhs.gov. Y1 - 2015/12/01/ PY - 2015 DA - 2015 Dec 01 SP - 52 EP - 62 VL - 51 KW - Chemokines KW - 0 KW - Cytokines KW - Nitric Oxide KW - 31C4KY9ESH KW - Nitrite Reductases KW - EC 1.7.- KW - Index Medicus KW - NO-induced cytokines and chemokines KW - Apoptosis KW - Nitrite reduction-derived nitric oxide KW - Biofilms KW - Infection KW - Bacterial pathogenesis KW - Oxidation-Reduction KW - Moraxellaceae Infections -- enzymology KW - Coculture Techniques KW - Moraxellaceae Infections -- microbiology KW - Bronchi -- cytology KW - Humans KW - Epithelial Cells -- microbiology KW - Cytokines -- immunology KW - Chemokines -- immunology KW - Cytokines -- metabolism KW - Host-Pathogen Interactions KW - Moraxella (Branhamella) catarrhalis -- physiology KW - Nitric Oxide -- metabolism KW - Moraxella (Branhamella) catarrhalis -- enzymology KW - Moraxella (Branhamella) catarrhalis -- pathogenicity KW - Nitrite Reductases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735910245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nitric+oxide+%3A+biology+and+chemistry&rft.atitle=Moraxella+catarrhalis-produced+nitric+oxide+has+dual+roles+in+pathogenicity+and+clearance+of+infection+in+bacterial-host+cell+co-cultures.&rft.au=Mocca%2C+Brian%3BYin%2C+Dandan%3BGao%2C+Yamei%3BWang%2C+Wei&rft.aulast=Mocca&rft.aufirst=Brian&rft.date=2015-12-01&rft.volume=51&rft.issue=&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Nitric+oxide+%3A+biology+and+chemistry&rft.issn=1089-8611&rft_id=info:doi/10.1016%2Fj.niox.2015.10.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-06 N1 - Date created - 2015-11-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.niox.2015.10.001 ER - TY - JOUR T1 - Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury. AN - 1735909684; 26491845 AB - The mechanism by which c-Jun N-terminal protein kinase (JNK) promotes tissue injury is poorly understood. Thus we aimed at studying the roles of JNK and its phospho-target proteins in mouse models of acute liver injury. Young male mice were exposed to a single dose of CCl4 (50mg/kg, IP) and euthanized at different time points. Liver histology, blood alanine aminotransferase, and other enzyme activities were measured in CCl4-exposed mice without or with the highly-specific JNK inhibitors. Phosphoproteins were purified from control or CCl4-exposed mice and analyzed by differential mass-spectrometry followed by further characterizations of immunoprecipitation and activity measurements. JNK was activated within 1h while liver damage was maximal at 24h post-CCl4 injection. Markedly increased phosphorylation of many mitochondrial proteins was observed between 1 and 8h following CCl4 exposure. Pretreatment with the selective JNK inhibitor SU3327 or the mitochondria-targeted antioxidant mito-TEMPO markedly reduced the levels of p-JNK, mitochondrial phosphoproteins and liver damage in CCl4-exposed mice. Differential proteomic analysis identified many phosphorylated mitochondrial proteins involved in anti-oxidant defense, electron transfer, energy supply, fatty acid oxidation, etc. Aldehyde dehydrogenase, NADH-ubiquinone oxidoreductase, and α-ketoglutarate dehydrogenase were phosphorylated in CCl4-exposed mice but dephosphorylated after SU3327 pretreatment. Consistently, the suppressed activities of these enzymes were restored by SU3327 pretreatment in CCl4-exposed mice. These data provide a novel mechanism by which JNK, rapidly activated by CCl4, promotes mitochondrial dysfunction and acute hepatotoxicity through robust phosphorylation of numerous mitochondrial proteins. Published by Elsevier B.V. JF - Redox biology AU - Jang, Sehwan AU - Yu, Li-Rong AU - Abdelmegeed, Mohamed A AU - Gao, Yuan AU - Banerjee, Atrayee AU - Song, Byoung-Joon AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-9410, USA. Electronic address: sehwan.jang@upr.edu. ; Biomarkers and Alternative Models Branch, Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: Lirong.Yu@fda.hhs.gov. ; Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-9410, USA. Electronic address: abdelmegeedm@mail.nih.gov. ; Biomarkers and Alternative Models Branch, Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: yuangao2000@gmail.com. ; Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-9410, USA. Electronic address: atrayee.liver@gmail.com. ; Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892-9410, USA. Electronic address: bj.song@nih.gov. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 552 EP - 564 VL - 6 KW - Bax protein, mouse KW - 0 KW - Mitochondrial Proteins KW - bcl-2-Associated X Protein KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - JNK KW - Carbon tetrachloride KW - Protein phosphorylation KW - Acute liver injury KW - Differential proteomics KW - Mitochondria KW - Mice, 129 Strain KW - Animals KW - Phosphorylation KW - Enzyme Activation KW - Protein Processing, Post-Translational KW - Cytochrome P-450 CYP2E1 -- physiology KW - Mitochondrial Proteins -- metabolism KW - Mice, Transgenic KW - Male KW - bcl-2-Associated X Protein -- metabolism KW - Mitochondria, Liver -- enzymology KW - JNK Mitogen-Activated Protein Kinases -- physiology KW - Acute Lung Injury -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735909684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Redox+biology&rft.atitle=Critical+role+of+c-jun+N-terminal+protein+kinase+in+promoting+mitochondrial+dysfunction+and+acute+liver+injury.&rft.au=Jang%2C+Sehwan%3BYu%2C+Li-Rong%3BAbdelmegeed%2C+Mohamed+A%3BGao%2C+Yuan%3BBanerjee%2C+Atrayee%3BSong%2C+Byoung-Joon&rft.aulast=Jang&rft.aufirst=Sehwan&rft.date=2015-12-01&rft.volume=6&rft.issue=&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=Redox+biology&rft.issn=2213-2317&rft_id=info:doi/10.1016%2Fj.redox.2015.09.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-05 N1 - Date created - 2015-11-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Ann Intern Med. 1986 Mar;104(3):399-404 [3511825] Redox Biol. 2014;3:109-23 [25465468] Antioxid Redox Signal. 2015 Mar 1;22(7):572-86 [25365698] Hepatology. 1991 Dec;14(6):1209-16 [1959871] Lancet. 1992 Aug 15;340(8816):384-7 [1353554] Science. 1995 Nov 24;270(5240):1326-31 [7481820] Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12908-13 [8917518] Chem Res Toxicol. 1997 Aug;10(8):895-905 [9282839] Biochem Pharmacol. 1998 Sep 15;56(6):773-9 [9751083] Toxicol Appl Pharmacol. 1998 Nov;153(1):109-18 [9875305] Toxicol Pathol. 2005;33(1):155-64 [15805067] J Hepatol. 2005 Jun;42(6):850-9 [15885356] Gastroenterology. 2006 Jul;131(1):165-78 [16831600] J Biol Chem. 2006 Jul 28;281(30):21256-65 [16709574] Exp Mol Med. 2006 Aug 31;38(4):408-16 [16953120] Hepatology. 2006 Nov;44(5):1218-30 [17058263] Microbiol Mol Biol Rev. 2006 Dec;70(4):1061-95 [17158707] Hepatology. 2007 Feb;45(2):412-21 [17366662] Gut. 2007 Jul;56(7):982-90 [17185352] Arch Toxicol. 2007 Jul;81(7):489-93 [17285312] Biochem J. 2007 Dec 15;408(3):297-315 [17850214] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] Proteomics. 2008 Sep;8(18):3906-18 [18780394] Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16809-13 [18922779] Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):E18; author reply E19 [19204298] J Med Chem. 2009 Apr 9;52(7):1943-52 [19271755] Expert Rev Proteomics. 2010 Feb;7(1):39-53 [20121475] Free Radic Biol Med. 2010 Feb 1;48(3):391-8 [19922789] Oncogene. 2010 Mar 18;29(11):1702-16 [20062077] EMBO J. 2011 Jan 19;30(2):249-62 [21131905] J Nutr. 2011 Apr 1;141(4):603-10 [21346097] J Biol Chem. 2000 Jan 7;275(1):322-7 [10617621] Toxicol Sci. 2001 Aug;62(2):212-20 [11452133] Mol Pharmacol. 2001 Oct;60(4):847-56 [11562448] Toxicol Appl Pharmacol. 2001 Dec 1;177(2):112-20 [11740910] Toxicol Sci. 2002 Feb;65(2):166-76 [11812920] Addiction. 2002 Jul;97(7):773-83 [12133112] Mol Pharmacol. 2003 Feb;63(2):401-8 [12527812] Biochem J. 2003 Apr 1;371(Pt 1):199-204 [12534346] Crit Rev Toxicol. 2003;33(2):105-36 [12708612] Biochem J. 2003 Jun 1;372(Pt 2):359-69 [12614194] Methods Mol Biol. 2004;282:103-15 [15105559] Hepatology. 2004 Jul;40(1):6-9 [15239078] JAMA. 1980 Jul 18;244(3):251-3 [7382090] Biochem Pharmacol. 1981 Dec 15;30(24):3265-75 [7034733] J Biol Chem. 2011 May 6;286(18):16052-62 [21454558] ACS Chem Biol. 2011 Aug 19;6(8):808-18 [21563797] J Biol Chem. 2011 Oct 7;286(40):35071-8 [21844199] J Proteomics. 2011 Nov 18;74(12):2745-59 [21884834] Drug Metab Rev. 2012 Feb;44(1):34-87 [21892896] Gastroenterology. 2012 Aug;143(2):307-20 [22705006] Gastroenterology. 2012 Sep;143(3):e1-7 [22796239] Hepatology. 2012 Nov;56(5):1599-601 [22729522] Free Radic Biol Med. 2013 Jul;60:211-22 [23454065] Free Radic Biol Med. 2013 Dec;65:1238-45 [24064383] Oxid Med Cell Longev. 2014;2014:149627 [24876909] Pharmacol Ther. 1989;43(1):139-54 [2675128] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.redox.2015.09.040 ER - TY - JOUR T1 - Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice. AN - 1735327516; 26464333 AB - Inhibitory G (Gi) proteins have been proposed to be cardioprotective. We investigated effects of Gαi2 knockout on cardiac function and survival in a murine heart failure model of cardiac β1-adrenoceptor overexpression. β1-transgenic mice lacking Gαi2 (β1-tg/Gαi2 (-/-)) were compared with wild-type mice and littermates either overexpressing cardiac β1-adrenoceptors (β1-tg) or lacking Gαi2 (Gαi2 (-/-)). At 300 days, mortality of mice only lacking Gαi2 was already higher compared with wild-type or β1-tg, but similar to β1-tg/Gαi2 (-/-), mice. Beyond 300 days, mortality of β1-tg/Gαi2 (-/-) mice was enhanced compared with all other genotypes (mean survival time: 363 ± 21 days). At 300 days of age, echocardiography revealed similar cardiac function of wild-type, β1-tg, and Gαi2 (-/-) mice, but significant impairment for β1-tg/Gαi2 (-/-) mice (e.g. ejection fraction 14 ± 2 vs. 40 ± 4% in wild-type mice). Significantly increased ventricle-to-body weight ratio (0.71 ± 0.06 vs. 0.48 ± 0.02% in wild-type mice), left ventricular size (length 0.82 ± 0.04 vs. 0.66 ± 0.03 cm in wild types), and atrial natriuretic peptide and brain natriuretic peptide expression (mRNA: 2819 and 495% of wild-type mice, respectively) indicated hypertrophy. Gαi3 was significantly up-regulated in Gαi2 knockout mice (protein compared with wild type: 340 ± 90% in Gαi2 (-/-) and 394 ± 80% in β1-tg/Gαi2 (-/-), respectively). Gαi2 deficiency combined with cardiac β1-adrenoceptor overexpression strongly impaired survival and cardiac function. At 300 days of age, β1-adrenoceptor overexpression alone had not induced cardiac hypertrophy or dysfunction while there was overt cardiomyopathy in mice additionally lacking Gαi2. We propose an enhanced effect of increased β1-adrenergic drive by the lack of protection via Gαi2. Gαi3 up-regulation was not sufficient to compensate for Gαi2 deficiency, suggesting an isoform-specific or a concentration-dependent mechanism. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com. JF - Cardiovascular research AU - Keller, Kirsten AU - Maass, Martina AU - Dizayee, Sara AU - Leiss, Veronika AU - Annala, Suvi AU - Köth, Jessica AU - Seemann, Wiebke K AU - Müller-Ehmsen, Jochen AU - Mohr, Klaus AU - Nürnberg, Bernd AU - Engelhardt, Stefan AU - Herzig, Stefan AU - Birnbaumer, Lutz AU - Matthes, Jan AD - Department of Pharmacology, University of Cologne, Gleueler Strasse 24, 50931 Cologne, Germany. ; Department of Internal Medicine III, University Hospital of Cologne, Cologne, Germany. ; Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Center of Pharmacogenomics and Drug Research, Tuebingen, Germany. ; Asklepios Klinik Altona, Hamburg, Germany. ; Pharmacology and Toxicology Section, Institute of Pharmacy, University of Bonn, Bonn, Germany. ; Institute of Pharmacology and Toxicology, Technische Universität München, Munich, Germany. ; Laboratory of Neurobiology, NIEHS, NIH (Department of Health and Human Services), Durham, USA. ; Department of Pharmacology, University of Cologne, Gleueler Strasse 24, 50931 Cologne, Germany jan.matthes@uni-koeln.de. Y1 - 2015/12/01/ PY - 2015 DA - 2015 Dec 01 SP - 348 EP - 356 VL - 108 IS - 3 KW - Adrb1 protein, mouse KW - 0 KW - Receptors, Adrenergic, beta-1 KW - Natriuretic Peptide, Brain KW - 114471-18-0 KW - Atrial Natriuretic Factor KW - 85637-73-6 KW - Cyclic AMP KW - E0399OZS9N KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - GTP-Binding Protein alpha Subunit, Gi2 KW - EC 3.6.5.1 KW - GTP-Binding Protein alpha Subunits, Gi-Go KW - Gnai2 protein, mouse KW - Gnai3 protein, mouse KW - Index Medicus KW - Cardiomyopathy KW - Cardioprotection KW - Heart failure KW - Adrenergic receptor KW - Inhibitory G protein KW - Ventricular Remodeling KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - Ventricular Function, Left KW - Animals KW - GTP-Binding Protein alpha Subunits, Gi-Go -- metabolism KW - Atrial Natriuretic Factor -- genetics KW - GTP-Binding Protein alpha Subunits, Gi-Go -- genetics KW - Natriuretic Peptide, Brain -- genetics KW - Disease Models, Animal KW - Ultrasonography KW - Mice, Knockout KW - Phenotype KW - Mice, 129 Strain KW - Natriuretic Peptide, Brain -- metabolism KW - Atrial Natriuretic Factor -- metabolism KW - Cyclic AMP -- metabolism KW - Mice, Inbred C57BL KW - Gene Expression Regulation KW - Genetic Predisposition to Disease KW - Time Factors KW - Stroke Volume KW - Receptors, Adrenergic, beta-1 -- metabolism KW - GTP-Binding Protein alpha Subunit, Gi2 -- genetics KW - Cardiomyopathy, Dilated -- diagnostic imaging KW - Heart Failure -- diagnostic imaging KW - Heart Failure -- metabolism KW - Myocytes, Cardiac -- pathology KW - Heart Failure -- genetics KW - Cardiomyopathy, Dilated -- physiopathology KW - GTP-Binding Protein alpha Subunit, Gi2 -- deficiency KW - Receptors, Adrenergic, beta-1 -- genetics KW - Cardiomyopathy, Dilated -- genetics KW - Heart Failure -- physiopathology KW - Cardiomyopathy, Dilated -- metabolism KW - Myocytes, Cardiac -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735327516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cardiovascular+research&rft.atitle=Lack+of+G%CE%B1i2+leads+to+dilative+cardiomyopathy+and+increased+mortality+in+%CE%B21-adrenoceptor+overexpressing+mice.&rft.au=Keller%2C+Kirsten%3BMaass%2C+Martina%3BDizayee%2C+Sara%3BLeiss%2C+Veronika%3BAnnala%2C+Suvi%3BK%C3%B6th%2C+Jessica%3BSeemann%2C+Wiebke+K%3BM%C3%BCller-Ehmsen%2C+Jochen%3BMohr%2C+Klaus%3BN%C3%BCrnberg%2C+Bernd%3BEngelhardt%2C+Stefan%3BHerzig%2C+Stefan%3BBirnbaumer%2C+Lutz%3BMatthes%2C+Jan&rft.aulast=Keller&rft.aufirst=Kirsten&rft.date=2015-12-01&rft.volume=108&rft.issue=3&rft.spage=348&rft.isbn=&rft.btitle=&rft.title=Cardiovascular+research&rft.issn=1755-3245&rft_id=info:doi/10.1093%2Fcvr%2Fcvv235 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-13 N1 - Date created - 2015-11-20 N1 - Date revised - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/cvr/cvv235 ER - TY - JOUR T1 - A fluorescence high throughput screening method for the detection of reactive electrophiles as potential skin sensitizers. AN - 1735325731; 26455772 AB - Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological and in silico methods are recommended to replace conventional animal tests. Chemical methods are intended to characterize the potential of a sensitizer to induce earlier molecular initiating events. The presence of an electrophilic mechanistic domain is considered one of the essential chemical features to covalently bind to the biological target and induce further haptenation processes. Current in chemico assays rely on the quantification of unreacted model nucleophiles after incubation with the candidate sensitizer. In the current study, a new fluorescence-based method, 'HTS-DCYA assay', is proposed. The assay aims at the identification of reactive electrophiles based on their chemical reactivity toward a model fluorescent thiol. The reaction workflow enabled the development of a High Throughput Screening (HTS) method to directly quantify the reaction adducts. The reaction conditions have been optimized to minimize solubility issues, oxidative side reactions and increase the throughput of the assay while minimizing the reaction time, which are common issues with existing methods. Thirty-six chemicals previously classified with LLNA, DPRA or KeratinoSens™ were tested as a proof of concept. Preliminary results gave an estimated 82% accuracy, 78% sensitivity, 90% specificity, comparable to other in chemico methods such as Cys-DPRA. In addition to validated chemicals, six natural products were analyzed and a prediction of their sensitization potential is presented for the first time. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Avonto, Cristina AU - Chittiboyina, Amar G AU - Rua, Diego AU - Khan, Ikhlas A AD - National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, United States. ; The Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD 20740, United States. ; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, United States; Division of Pharmacognosy, Department of BioMolecular Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, United States. Electronic address: ikhan@olemiss.edu. Y1 - 2015/12/01/ PY - 2015 DA - 2015 Dec 01 SP - 177 EP - 184 VL - 289 IS - 2 KW - Allergens KW - 0 KW - Dansyl Compounds KW - Fluorescent Dyes KW - Cysteamine KW - 5UX2SD1KE2 KW - Index Medicus KW - Electrophiles, KW - Skin sensitization, KW - In chemico alternative methods, KW - Fluorescence assay, KW - High throughput screening KW - Animals KW - Workflow KW - Spectrometry, Fluorescence KW - Reproducibility of Results KW - Humans KW - Reference Standards KW - Calibration KW - Local Lymph Node Assay KW - Time Factors KW - Risk Assessment KW - Animal Testing Alternatives KW - Allergens -- chemistry KW - Dermatitis, Allergic Contact -- etiology KW - High-Throughput Screening Assays -- standards KW - Cysteamine -- analogs & derivatives KW - Allergens -- toxicity KW - Fluorescent Dyes -- chemistry KW - Skin Irritancy Tests -- standards KW - Skin Irritancy Tests -- methods KW - Dansyl Compounds -- chemistry KW - Cysteamine -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735325731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=A+fluorescence+high+throughput+screening+method+for+the+detection+of+reactive+electrophiles+as+potential+skin+sensitizers.&rft.au=Avonto%2C+Cristina%3BChittiboyina%2C+Amar+G%3BRua%2C+Diego%3BKhan%2C+Ikhlas+A&rft.aulast=Avonto&rft.aufirst=Cristina&rft.date=2015-12-01&rft.volume=289&rft.issue=2&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.09.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-08 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.09.027 ER - TY - JOUR T1 - Impact of climate change on the domestic indoor environment and associated health risks in the UK. AN - 1733930472; 26453820 AB - There is growing evidence that projected climate change has the potential to significantly affect public health. In the UK, much of this impact is likely to arise by amplifying existing risks related to heat exposure, flooding, and chemical and biological contamination in buildings. Identifying the health effects of climate change on the indoor environment, and risks and opportunities related to climate change adaptation and mitigation, can help protect public health. We explored a range of health risks in the domestic indoor environment related to climate change, as well as the potential health benefits and unintended harmful effects of climate change mitigation and adaptation policies in the UK housing sector. We reviewed relevant scientific literature, focusing on housing-related health effects in the UK likely to arise through either direct or indirect mechanisms of climate change or mitigation and adaptation measures in the built environment. We considered the following categories of effect: (i) indoor temperatures, (ii) indoor air quality, (iii) indoor allergens and infections, and (iv) flood damage and water contamination. Climate change may exacerbate health risks and inequalities across these categories and in a variety of ways, if adequate adaptation measures are not taken. Certain changes to the indoor environment can affect indoor air quality or promote the growth and propagation of pathogenic organisms. Measures aimed at reducing greenhouse gas emissions have the potential for ancillary public health benefits including reductions in health burdens related heat and cold, indoor exposure to air pollution derived from outdoor sources, and mould growth. However, increasing airtightness of dwellings in pursuit of energy efficiency could also have negative effects by increasing concentrations of pollutants (such as PM2.5, CO and radon) derived from indoor or ground sources, and biological contamination. These effects can largely be ameliorated by mechanical ventilation with heat recovery (MVHR) and air filtration, where such solution is feasible and when the system is properly installed, operated and maintained. Groups at high risk of these adverse health effects include the elderly (especially those living on their own), individuals with pre-existing illnesses, people living in overcrowded accommodation, and the socioeconomically deprived. A better understanding of how current and emerging building infrastructure design, construction, and materials may affect health in the context of climate change and mitigation and adaptation measures is needed in the UK and other high income countries. Long-term, energy efficient building design interventions, ensuring adequate ventilation, need to be promoted. Crown Copyright © 2015. Published by Elsevier Ltd. All rights reserved. JF - Environment international AU - Vardoulakis, Sotiris AU - Dimitroulopoulou, Chrysanthi AU - Thornes, John AU - Lai, Ka-Man AU - Taylor, Jonathon AU - Myers, Isabella AU - Heaviside, Clare AU - Mavrogianni, Anna AU - Shrubsole, Clive AU - Chalabi, Zaid AU - Davies, Michael AU - Wilkinson, Paul AD - Environmental Change Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Oxon OX11 0RQ, UK; Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, UK; Division of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: sotiris.vardoulakis@phe.gov.uk. ; Environmental Change Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Oxon OX11 0RQ, UK. Electronic address: Sani.Dimitroulopoulou@phe.gov.uk. ; Environmental Change Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Oxon OX11 0RQ, UK; Division of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: John.Thornes@phe.gov.uk. ; Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. Electronic address: laikaman@hkbu.edu.hk. ; UCL Institute for Environmental Design and Engineering, The Bartlett School of Environment Energy and Resources, University College London, 14 Upper Woburn Place, London WCIH ONN, UK. Electronic address: j.g.taylor@ucl.ac.uk. ; Public Health England Toxicology Unit, Department of Medicine, Imperial College London, London W12 0NN, UK. Electronic address: Isabella.Myers@phe.gov.uk. ; Environmental Change Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Oxon OX11 0RQ, UK; Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, UK; Division of Environmental Health and Risk Management, School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address: Clare.Heaviside@phe.gov.uk. ; UCL Institute for Environmental Design and Engineering, The Bartlett School of Environment Energy and Resources, University College London, 14 Upper Woburn Place, London WCIH ONN, UK. Electronic address: a.mavrogianni@ucl.ac.uk. ; UCL Institute for Environmental Design and Engineering, The Bartlett School of Environment Energy and Resources, University College London, 14 Upper Woburn Place, London WCIH ONN, UK. Electronic address: clive.shrubsole.09@ucl.ac.uk. ; Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, UK. Electronic address: zaid.chalabi@lshtm.ac.uk. ; UCL Institute for Environmental Design and Engineering, The Bartlett School of Environment Energy and Resources, University College London, 14 Upper Woburn Place, London WCIH ONN, UK. Electronic address: michael.davies@ucl.ac.uk. ; Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London WC1H 9SH, UK. Electronic address: Paul.Wilkinson@lshtm.ac.uk. Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 299 EP - 313 VL - 85 KW - Particulate Matter KW - 0 KW - Carbon Monoxide KW - 7U1EE4V452 KW - Radon KW - Q74S4N8N1G KW - Index Medicus KW - Overheating KW - Climate change KW - Adaptation KW - Air quality KW - Mould KW - Public health KW - Public Health KW - Carbon Monoxide -- analysis KW - Ventilation KW - Particle Size KW - Humans KW - Radon -- analysis KW - Aged KW - Particulate Matter -- analysis KW - United Kingdom KW - Risk Assessment KW - Models, Theoretical KW - Air Pollution, Indoor -- analysis KW - Housing -- standards KW - Climate Change KW - Air Pollution, Indoor -- prevention & control KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1733930472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Impact+of+climate+change+on+the+domestic+indoor+environment+and+associated+health+risks+in+the+UK.&rft.au=Vardoulakis%2C+Sotiris%3BDimitroulopoulou%2C+Chrysanthi%3BThornes%2C+John%3BLai%2C+Ka-Man%3BTaylor%2C+Jonathon%3BMyers%2C+Isabella%3BHeaviside%2C+Clare%3BMavrogianni%2C+Anna%3BShrubsole%2C+Clive%3BChalabi%2C+Zaid%3BDavies%2C+Michael%3BWilkinson%2C+Paul&rft.aulast=Vardoulakis&rft.aufirst=Sotiris&rft.date=2015-12-01&rft.volume=85&rft.issue=&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2015.09.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-23 N1 - Date created - 2015-11-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2015.09.010 ER - TY - JOUR T1 - Novel 5'/3'RACE Method for Amplification and Determination of Single-Stranded RNAs Through Double-Stranded RNA (dsRNA) Intermediates AN - 1732838395; PQ0002229438 AB - To acquire the full-length sequences and to determine the 5'/3'ends of the RNA genomes and mRNA transcripts using the rapid amplification of cDNA ends (RACE) protocols-via cDNA or mRNA templates-are a great challenge. This 4-steps RNA-based RACE method uses different ways to determine the RNA ends through a double-stranded (ds) RNA intermediate (dsRNA-RACE). In the first step a complementary RNA strand is synthesised by Phi6 RNA replicase enzyme next to the template ssRNA forming a dsRNA intermediate. The following steps include adapter ligation, nucleic acid purification and two classical methods with minor modifications reverse transcription and polymerase chain reaction. The dsRNA-RACE protocol could be used in wide variety of ssRNA (cellular, viral, bacterial, etc.) templates in the field of microbiology and cellular biology and suitable for the amplification of full-length RNAs including the 5'/3'ends. This is a novel, expansively utilizable molecular tool with fewer disadvantages than the existing 5'/3'RACE approaches. JF - Molecular Biotechnology AU - Pankovics, Peter AU - Boros, Akos AU - Reuter, Gabor AD - Regional Laboratory of Virology, National Reference Laboratory of Gastroenteric Viruses, ANTSZ Regional Institute of State Public Health Service, Szabadsag ut 7, Pecs, 7623, Hungary, reuter.gabor@gmail.com Y1 - 2015/12// PY - 2015 DA - December 2015 SP - 974 EP - 981 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 57 IS - 11-12 SN - 1073-6085, 1073-6085 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - nucleic acids KW - Double-stranded RNA KW - RNA-directed RNA polymerase KW - Enzymes KW - Polymerase chain reaction KW - Purification KW - replicase KW - Reverse transcription KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732838395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=Novel+5%27%2F3%27RACE+Method+for+Amplification+and+Determination+of+Single-Stranded+RNAs+Through+Double-Stranded+RNA+%28dsRNA%29+Intermediates&rft.au=Pankovics%2C+Peter%3BBoros%2C+Akos%3BReuter%2C+Gabor&rft.aulast=Pankovics&rft.aufirst=Peter&rft.date=2015-12-01&rft.volume=57&rft.issue=11-12&rft.spage=974&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1007%2Fs12033-015-9889-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Number of references - 28 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Genomes; nucleic acids; RNA-directed RNA polymerase; Double-stranded RNA; Polymerase chain reaction; Enzymes; Purification; replicase; Reverse transcription DO - http://dx.doi.org/10.1007/s12033-015-9889-7 ER - TY - JOUR T1 - Cancer incidence and metolachlor use in the Agricultural Health Study: An update. AN - 1713526837; 26033014 AB - Metolachlor, a widely used herbicide, is classified as a Group C carcinogen by the U.S. Environmental Protection Agency based on increased liver neoplasms in female rats. Epidemiologic studies of the health effects of metolachlor have been limited. The Agricultural Health Study (AHS) is a prospective cohort study including licensed private and commercial pesticide applicators in Iowa and North Carolina enrolled 1993-1997. We evaluated cancer incidence through 2010/2011 (NC/IA) for 49,616 applicators, 53% of whom reported ever using metolachlor. We used Poisson regression to evaluate relations between two metrics of metolachlor use (lifetime days, intensity-weighted lifetime days) and cancer incidence. We saw no association between metolachlor use and incidence of all cancers combined (n = 5,701 with a 5-year lag) or most site-specific cancers. For liver cancer, in analyses restricted to exposed workers, elevations observed at higher categories of use were not statistically significant. However, trends for both lifetime and intensity-weighted lifetime days of metolachor use were positive and statistically significant with an unexposed reference group. A similar pattern was observed for follicular cell lymphoma, but no other lymphoma subtypes. An earlier suggestion of increased lung cancer risk at high levels of metolachlor use in this cohort was not confirmed in this update. This suggestion of an association between metolachlor and liver cancer among pesticide applicators is a novel finding and echoes observation of increased liver neoplasms in some animal studies. However, our findings for both liver cancer and follicular cell lymphoma warrant follow-up to better differentiate effects of metolachlor use from other factors. © 2015 UICC. JF - International journal of cancer AU - Silver, Sharon R AU - Bertke, Steven J AU - Hines, Cynthia J AU - Alavanja, Michael C R AU - Hoppin, Jane A AU - Lubin, Jay H AU - Rusiecki, Jennifer A AU - Sandler, Dale P AU - Beane Freeman, Laura E AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH. ; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD. ; Department of Biological Sciences, North Carolina State University, Raleigh, NC. ; Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD. ; Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC. Y1 - 2015/12/01/ PY - 2015 DA - 2015 Dec 01 SP - 2630 EP - 2643 VL - 137 IS - 11 KW - Acetamides KW - 0 KW - Carcinogens KW - Herbicides KW - metolachlor KW - X0I01K05X2 KW - Index Medicus KW - pesticide KW - occupation KW - epidemiology KW - cancer KW - Prospective Studies KW - Humans KW - Cohort Studies KW - Occupational Exposure -- adverse effects KW - Incidence KW - Aged KW - Middle Aged KW - North Carolina -- epidemiology KW - Male KW - Iowa -- epidemiology KW - Female KW - Agricultural Workers' Diseases -- epidemiology KW - Acetamides -- toxicity KW - Agricultural Workers' Diseases -- chemically induced KW - Neoplasms -- epidemiology KW - Carcinogens -- toxicity KW - Herbicides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1713526837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Cancer+incidence+and+metolachlor+use+in+the+Agricultural+Health+Study%3A+An+update.&rft.au=Silver%2C+Sharon+R%3BBertke%2C+Steven+J%3BHines%2C+Cynthia+J%3BAlavanja%2C+Michael+C+R%3BHoppin%2C+Jane+A%3BLubin%2C+Jay+H%3BRusiecki%2C+Jennifer+A%3BSandler%2C+Dale+P%3BBeane+Freeman%2C+Laura+E&rft.aulast=Silver&rft.aufirst=Sharon&rft.date=2015-12-01&rft.volume=137&rft.issue=11&rft.spage=2630&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/10.1002%2Fijc.29621 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-14 N1 - Date created - 2015-09-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2005;23(2):261-78 [16291529] Ecotoxicol Environ Saf. 2006 Mar;63(3):451-5 [16406594] Int J Cancer. 2006 Jun 15;118(12):3118-23 [16425265] Food Chem Toxicol. 2007 May;45(5):871-7 [17207564] Int J Cancer. 2007 Jul 15;121(2):339-46 [17390374] Blood. 2007 Jul 15;110(2):695-708 [17389762] J Biochem Mol Toxicol. 2008 Feb;22(1):41-50 [18273908] Environ Health Perspect. 2010 Jun;118(6):812-7 [20164001] Cancer Causes Control. 2010 Nov;21(11):1759-75 [20730623] Environ Health Perspect. 2000 Dec;108(12):1151-7 [11133395] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Int J Toxicol. 2003 Jul-Aug;22(4):287-95 [12933323] Am J Epidemiol. 2004 Feb 15;159(4):373-80 [14769641] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Mutat Res. 1997 Dec 12;395(2-3):159-71 [9465927] Mutat Res. 1999 Jul 15;443(1-2):183-221 [10415440] Scand J Work Environ Health. 2005;31 Suppl 1:39-45; discussion 5-7 [16190148] Int J Environ Res Public Health. 2011 Dec;8(12):4608-22 [22408592] J Expo Sci Environ Epidemiol. 2012 Jul;22(4):409-16 [22569205] J Expo Sci Environ Epidemiol. 2012 Nov;22(6):584-92 [22854518] Food Chem Toxicol. 2013 Dec;62:777-81 [24144947] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/ijc.29621 ER - TY - JOUR T1 - PubChem atom environments AN - 1712773242; PQ0001973747 AB - Background: Atom environments and fragments find wide-spread use in chemical information and cheminformatics. They are the basis of prediction models, an integral part in similarity searching, and employed in structure search techniques. Most of these methods were developed and evaluated on the relatively small sets of chemical structures available at the time. An analysis of fragment distributions representative of most known chemical structures was published in the 1970s using the Chemical Abstracts Service data system. More recently, advances in automated synthesis of chemicals allow millions of chemicals to be synthesized by a single organization. In addition, open chemical databases are readily available containing tens of millions of chemical structures from a multitude of data sources, including chemical vendors, patents, and the scientific literature, making it possible for scientists to readily access most known chemical structures. With this availability of information, one can now address interesting questions, such as: what chemical fragments are known today? How do these fragments compare to earlier studies? How unique are chemical fragments found in chemical structures? Results: For our analysis, after hydrogen suppression, atoms were characterized by atomic number, formal charge, implicit hydrogen count, explicit degree (number of neighbors), valence (bond order sum), and aromaticity. Bonds were differentiated as single, double, triple or aromatic bonds. Atom environments were created in a circular manner focused on a central atom with radii from 0 (atom types) up to 3 (representative of ECFP_6 fragments). In total, combining atom types and atom environments that include up to three spheres of nearest neighbors, our investigation identified 28,462,319 unique fragments in the 46 million structures found in the PubChem Compound database as of January 2013. We could identify several factors inflating the number of environments involving transition metals, with many seemingly due to erroneous interpretation of structures from patent data. Compared to fragmentation statistics published 40 years ago, the exponential growth in chemistry is mirrored in a nearly eightfold increase in the number of unique chemical fragments; however, this result is clearly an upper bound estimate as earlier studies employed structure sampling approaches and this study shows that a relatively high rate of atom fragments are found in only a single chemical structure (singletons). In addition, the percentage of singletons grows as the size of the chemical fragment is increased. Conclusions: The observed growth of the numbers of unique fragments over time suggests that many chemically possible connections of atom types to larger fragments have yet to be explored by chemists. A dramatic drop in the relative rate of increase of atom environments from smaller to larger fragments shows that larger fragments mainly consist of diverse combinations of a limited subset of smaller fragments. This is further supported by the observed concomitant increase of singleton atom environments. Combined, these findings suggest that there is considerable opportunity for chemists to combine known fragments to novel chemical compounds. The comparison of PubChem to an older study of known chemical structures shows noticeable differences. The changes suggest advances in synthetic capabilities of chemists to combine atoms in new patterns. Log-log plots of fragment incidence show small numbers of fragments are found in many structures and that large numbers of fragments are found in very few structures, with nearly half being novel using the methods in this work. The relative decrease in the count of new fragments as a function of size further suggests considerable opportunity for more novel chemicals exists. Lastly, the differences in atom environment diversity between PubChem Substance and Compound showcase the effect of PubChem standardization protocols, but also indicate that a normalization procedure for atom types, functional groups, and tautomeric/resonance forms based on atom environments is possible. The complete sets of atom types and atom environments are supplied as supporting information. Graphical abstract: [Figure not available: see fulltext.] JF - Journal of Cheminformatics AU - Haehnke, Volker D AU - Bolton, Evan E AU - Bryant, Stephen H AD - Department of Health and Human Services, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD, 20894, USA, bolton@ncbi.nlm.nih.gov Y1 - 2015/12// PY - 2015 DA - Dec 2015 SP - 1 EP - 37 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 7 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Standardization KW - Data processing KW - Informatics KW - Patents KW - Statistical analysis KW - Transition metals KW - Hydrogen KW - Sampling KW - Aromatics KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712773242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cheminformatics&rft.atitle=PubChem+atom+environments&rft.au=Haehnke%2C+Volker+D%3BBolton%2C+Evan+E%3BBryant%2C+Stephen+H&rft.aulast=Haehnke&rft.aufirst=Volker&rft.date=2015-12-01&rft.volume=7&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cheminformatics&rft.issn=1758-2946&rft_id=info:doi/10.1186%2Fs13321-015-0076-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 80 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Standardization; Databases; Data processing; Informatics; Patents; Statistical analysis; Transition metals; Sampling; Hydrogen; Aromatics; Models DO - http://dx.doi.org/10.1186/s13321-015-0076-4 ER - TY - JOUR T1 - Considerations for Using Genetic and Epigenetic Information in Occupational Health Risk Assessment and Standard Setting AN - 1790971291; PQ0002965569 AB - Risk assessment forms the basis for both occupational health decision-making and the development of occupational exposure limits (OELs). Although genetic and epigenetic data have not been widely used in risk assessment and ultimately, standard setting, it is possible to envision such uses. A growing body of literature demonstrates that genetic and epigenetic factors condition biological responses to occupational and environmental hazards or serve as targets of them. This presentation addresses the considerations for using genetic and epigenetic information in risk assessments, provides guidance on using this information within the classic risk assessment paradigm, and describes a framework to organize thinking about such uses. The framework is a 4 4 matrix involving the risk assessment functions (hazard identification, dose-response modeling, exposure assessment, and risk characterization) on one axis and inherited and acquired genetic and epigenetic data on the other axis. The cells in the matrix identify how genetic and epigenetic data can be used for each risk assessment function. Generally, genetic and epigenetic data might be used as endpoints in hazard identification, as indicators of exposure, as effect modifiers in exposure assessment and dose-response modeling, as descriptors of mode of action, and to characterize toxicity pathways. Vast amounts of genetic and epigenetic data may be generated by high-throughput technologies. These data can be useful for assessing variability and reducing uncertainty in extrapolations, and they may serve as the foundation upon which identification of biological perturbations would lead to a new paradigm of toxicity pathway-based risk assessments. JF - Journal of Occupational and Environmental Hygiene AU - Schulte, P A AU - Whittaker, C AU - Curran, C P AD - Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Education and Information Division, Cincinnati, Ohio Y1 - 2015/11/25/ PY - 2015 DA - 2015 Nov 25 SP - S69 EP - S81 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 12 IS - sup1 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Data processing KW - Toxicity KW - Decision making KW - Environmental hazards KW - epigenetics KW - Dose-response effects KW - Risk factors KW - Occupational exposure KW - Occupational health KW - Technology KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790971291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Considerations+for+Using+Genetic+and+Epigenetic+Information+in+Occupational+Health+Risk+Assessment+and+Standard+Setting&rft.au=Schulte%2C+P+A%3BWhittaker%2C+C%3BCurran%2C+C+P&rft.aulast=Schulte&rft.aufirst=P&rft.date=2015-11-25&rft.volume=12&rft.issue=sup1&rft.spage=S69&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2015.1060323 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Decision making; Data processing; epigenetics; Toxicity; Occupational exposure; Environmental hygiene; Environmental hazards; Risk factors; Dose-response effects; Technology; Occupational health DO - http://dx.doi.org/10.1080/15459624.2015.1060323 ER - TY - JOUR T1 - Setting Occupational Exposure Limits for Chemical Allergens-Understanding the Challenges AN - 1790970483; PQ0002965575 AB - Chemical allergens represent a significant health burden in the workplace. Exposures to such chemicals can cause the onset of a diverse group of adverse health effects triggered by immune-mediated responses. Common responses associated with workplace exposures to low molecular weight (LMW) chemical allergens range from allergic contact dermatitis to life-threatening cases of asthma. Establishing occupational exposure limits (OELs) for chemical allergens presents numerous difficulties for occupational hygiene professionals. Few OELs have been developed for LMW allergens because of the unique biological mechanisms that govern the immune-mediated responses. The purpose of this article is to explore the primary challenges confronting the establishment of OELs for LMW allergens. Specific topics include: (1) understanding the biology of LMW chemical allergies as it applies to setting OELs; (2) selecting the appropriate immune-mediated response (i.e., sensitization versus elicitation); (3) characterizing the dose (concentration)-response relationship of immune-mediated responses; (4) determining the impact of temporal exposure patterns (i.e., cumulative versus acute exposures); and (5) understanding the role of individual susceptibility and exposure route. Additional information is presented on the importance of using alternative exposure recommendations and risk management practices, including medical surveillance, to aid in protecting workers from exposures to LMW allergens when OELs cannot be established. JF - Journal of Occupational and Environmental Hygiene AU - Dotson, G S AU - Maier, A AU - Siegel, P D AU - Anderson, SE AU - Green, B J AU - Stefaniak, AB AU - Codispoti, C D AU - Kimber, I AD - Education and Information Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2015/11/25/ PY - 2015 DA - 2015 Nov 25 SP - S82 EP - S98 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 12 IS - sup1 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Immunology Abstracts; Health & Safety Science Abstracts KW - Contact dermatitis KW - Asthma KW - Respiratory diseases KW - Allergies KW - Risk management KW - Hypersensitivity KW - Allergens KW - Hygiene KW - Occupational exposure KW - Occupational health KW - Environmental hygiene KW - F 06925:Hypersensitivity KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790970483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Setting+Occupational+Exposure+Limits+for+Chemical+Allergens-Understanding+the+Challenges&rft.au=Dotson%2C+G+S%3BMaier%2C+A%3BSiegel%2C+P+D%3BAnderson%2C+SE%3BGreen%2C+B+J%3BStefaniak%2C+AB%3BCodispoti%2C+C+D%3BKimber%2C+I&rft.aulast=Dotson&rft.aufirst=G&rft.date=2015-11-25&rft.volume=12&rft.issue=sup1&rft.spage=S82&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2015.1072277 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Hypersensitivity; Contact dermatitis; Allergens; Asthma; Hygiene; Occupational exposure; Environmental hygiene; Risk management; Respiratory diseases; Allergies; Occupational health DO - http://dx.doi.org/10.1080/15459624.2015.1072277 ER - TY - JOUR T1 - Aggregate Exposure and Cumulative Risk Assessment-Integrating Occupational and Non-occupational Risk Factors AN - 1790967328; PQ0002965571 AB - Occupational exposure limits have traditionally focused on preventing morbidity and mortality arising from inhalation exposures to individual chemical stressors in the workplace. While central to occupational risk assessment, occupational exposure limits have limited application as a refined disease prevention tool because they do not account for all of the complexities of the work and non-occupational environments and are based on varying health endpoints. To be of greater utility, occupational exposure limits and other risk management tools could integrate broader consideration of risks from multiple exposure pathways and routes (aggregate risk) as well as the combined risk from exposure to both chemical and non-chemical stressors, within and beyond the workplace, including the possibility that such exposures may cause interactions or modify the toxic effects observed (cumulative risk). Although still at a rudimentary stage in many cases, a variety of methods and tools have been developed or are being used in allied risk assessment fields to incorporate such considerations in the risk assessment process. These approaches, which are collectively referred to as cumulative risk assessment, have potential to be adapted or modified for occupational scenarios and provide a tangible path forward for occupational risk assessment. Accounting for complex exposures in the workplace and the broader risks faced by the individual also requires a more complete consideration of the composite effects of occupational and non-occupational risk factors to fully assess and manage worker health problems. Barriers to integrating these different factors remain, but new and ongoing community-based and worker health-related initiatives may provide mechanisms for identifying and integrating risk from aggregate exposures and cumulative risks from all relevant sources, be they occupational or non-occupational. JF - Journal of Occupational and Environmental Hygiene AU - Lentz, T J AU - Dotson, G S AU - Williams, PRD AU - Maier, A AU - Gadagbui, B AU - Pandalai, S P AU - Lamba, A AU - Hearl, F AU - Mumtaz, M AD - Education and Information Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio Y1 - 2015/11/25/ PY - 2015 DA - 2015 Nov 25 SP - S112 EP - S126 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 12 IS - sup1 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Inhalation KW - Mortality KW - Health problems KW - Community involvement KW - Toxicity KW - Morbidity KW - Risk management KW - Workers KW - Prevention KW - Risk factors KW - Occupational exposure KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790967328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Aggregate+Exposure+and+Cumulative+Risk+Assessment-Integrating+Occupational+and+Non-occupational+Risk+Factors&rft.au=Lentz%2C+T+J%3BDotson%2C+G+S%3BWilliams%2C+PRD%3BMaier%2C+A%3BGadagbui%2C+B%3BPandalai%2C+S+P%3BLamba%2C+A%3BHearl%2C+F%3BMumtaz%2C+M&rft.aulast=Lentz&rft.aufirst=T&rft.date=2015-11-25&rft.volume=12&rft.issue=sup1&rft.spage=S112&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2015.1060326 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Inhalation; Risk assessment; Mortality; Workers; Risk factors; Morbidity; Occupational exposure; Environmental hygiene; Risk management; Prevention; Health problems; Community involvement; Toxicity DO - http://dx.doi.org/10.1080/15459624.2015.1060326 ER - TY - JOUR T1 - Systems Biology and Biomarkers of Early Effects for Occupational Exposure Limit Setting AN - 1790967310; PQ0002965570 AB - In a recent National Research Council document, new strategies for risk assessment were described to enable more accurate and quicker assessments. super(() super(1) super()) This report suggested that evaluating individual responses through increased use of bio-monitoring could improve dose-response estimations. Identi-fication of specific biomarkers may be useful for diagnostics or risk prediction as they have the potential to improve exposure assessments. This paper discusses systems biology, biomarkers of effect, and computational toxicology approaches and their relevance to the occupational exposure limit setting process. The systems biology approach evaluates the integration of biological processes and how disruption of these processes by chemicals or other hazards affects disease outcomes. This type of approach could provide information used in delineating the mode of action of the response or toxicity, and may be useful to define the low adverse and no adverse effect levels. Biomarkers of effect are changes measured in biological systems and are considered to be preclinical in nature. Advances in computational methods and experimental -omics methods that allow the simultaneous measurement of families of macromolecules such as DNA, RNA, and proteins in a single analysis have made these systems approaches feasible for broad application. The utility of the information for risk assessments from -omics approaches has shown promise and can provide information on mode of action and dose-response relationships. As these techniques evolve, estimation of internal dose and response biomarkers will be a critical test of these new technologies for application in risk assessment strategies. While proof of concept studies have been conducted that provide evidence of their value, challenges with standardization and harmonization still need to be overcome before these methods are used routinely. JF - Journal of Occupational and Environmental Hygiene AU - DeBord, DGayle AU - Burgoon, Lyle AU - Edwards, Stephen W AU - Haber, Lynne T AU - Kanitz, MHelen AU - Kuempel, Eileen AU - Thomas, Russell S AU - Yucesoy, Berran AD - National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio Y1 - 2015/11/25/ PY - 2015 DA - 2015 Nov 25 SP - S41 EP - S54 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 12 IS - sup1 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Prediction KW - Risk assessment KW - Macromolecules KW - Standardization KW - Integration KW - Dose-response effects KW - Toxicology KW - Occupational exposure KW - Environmental hygiene KW - Bioindicators KW - Toxicity KW - Computer applications KW - Councils KW - biomarkers KW - RNA KW - DNA KW - Proteins KW - Standards KW - Side effects KW - Technology KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790967310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Systems+Biology+and+Biomarkers+of+Early+Effects+for+Occupational+Exposure+Limit+Setting&rft.au=DeBord%2C+DGayle%3BBurgoon%2C+Lyle%3BEdwards%2C+Stephen+W%3BHaber%2C+Lynne+T%3BKanitz%2C+MHelen%3BKuempel%2C+Eileen%3BThomas%2C+Russell+S%3BYucesoy%2C+Berran&rft.aulast=DeBord&rft.aufirst=DGayle&rft.date=2015-11-25&rft.volume=12&rft.issue=sup1&rft.spage=S41&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2015.1060324 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Risk assessment; Macromolecules; Toxicity; Computer applications; biomarkers; Integration; Standardization; RNA; Dose-response effects; DNA; Occupational exposure; Side effects; Environmental hygiene; Bioindicators; Prediction; Chemicals; Councils; Proteins; Standards; Toxicology; Technology DO - http://dx.doi.org/10.1080/15459624.2015.1060324 ER - TY - JOUR T1 - Instrumental improvements and sample preparations that enable reproducible, reliable acquisition of mass spectra from whole bacterial cells. AN - 1720452077; 26443394 AB - Rapid sub-species characterization of pathogens is required for timely responses in outbreak situations. Pyrolysis mass spectrometry (PyMS) has the potential to be used for this purpose. However, in order to make PyMS practical for traceback applications, certain improvements related to spectrum reproducibility and data acquisition speed were required. The main objectives of this study were to facilitate fast detection (<30 min to analyze 6 samples, including preparation) and sub-species-level bacterial characterization based on pattern recognition of mass spectral fingerprints acquired from whole cells volatilized and ionized at atmospheric pressure. An AccuTOF DART mass spectrometer was re-engineered to permit ionization of low-volatility bacteria by means of Plasma Jet Ionization (PJI), in which an electric discharge, and, by extension, a plasma beam, impinges on sample cells. Instrumental improvements and spectral acquisition methodology are described. Performance of the re-engineered system was assessed using a small challenge set comprised of assorted bacterial isolates differing in identity by varying amounts. In general, the spectral patterns obtained allowed differentiation of all samples tested, including those of the same genus and species but different serotypes. Fluctuations of ±15% in bacterial cell concentrations did not substantially compromise replicate spectra reproducibility. © 2015 National Center for Toxicological Research. Rapid Communications in Mass Spectrometry published by John Wiley & Sons Ltd. JF - Rapid communications in mass spectrometry : RCM AU - Alusta, Pierre AU - Buzatu, Dan AU - Williams, Anna AU - Cooper, Willie-Mae AU - Tarasenko, Olga AU - Dorey, R Cameron AU - Hall, Reggie AU - Parker, W Ryan AU - Wilkes, Jon G AD - Innovative Safety Technologies Branch, Systems Biology Div., National Center for Toxicological Research, Food Drug Administration, Jefferson, AR, USA. ; University of Arkansas at Little Rock, Department of Biology, Little Rock, AR, USA. ; Bionetics Corp., National Center for Toxicological Research, Food Drug Administration, Jefferson, AR, USA. ; Department of Chemistry, University of Texas, Austin, TX, USA. Y1 - 2015/11/15/ PY - 2015 DA - 2015 Nov 15 SP - 1961 EP - 1968 VL - 29 IS - 21 KW - Index Medicus KW - Reproducibility of Results KW - Specimen Handling KW - Mass Spectrometry -- instrumentation KW - Bacterial Typing Techniques -- methods KW - Bacterial Typing Techniques -- instrumentation KW - Mass Spectrometry -- methods KW - Bacteria -- isolation & purification KW - Bacteria -- classification KW - Mass Spectrometry -- economics KW - Bacterial Typing Techniques -- economics KW - Bacteria -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1720452077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Instrumental+improvements+and+sample+preparations+that+enable+reproducible%2C+reliable+acquisition+of+mass+spectra+from+whole+bacterial+cells.&rft.au=Alusta%2C+Pierre%3BBuzatu%2C+Dan%3BWilliams%2C+Anna%3BCooper%2C+Willie-Mae%3BTarasenko%2C+Olga%3BDorey%2C+R+Cameron%3BHall%2C+Reggie%3BParker%2C+W+Ryan%3BWilkes%2C+Jon+G&rft.aulast=Alusta&rft.aufirst=Pierre&rft.date=2015-11-15&rft.volume=29&rft.issue=21&rft.spage=1961&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=1097-0231&rft_id=info:doi/10.1002%2Frcm.7299 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-14 N1 - Date created - 2015-10-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Appl Environ Microbiol. 2008 Sep;74(17):5402-7 [18606788] J Clin Microbiol. 2008 Jun;46(6):1946-54 [18400920] Analyst. 2009 Mar;134(3):557-63 [19238294] Nat Rev Microbiol. 2010 Jan;8(1):74-82 [20010952] Food Microbiol. 2012 May;30(1):281-8 [22265313] J R Soc Interface. 2012 Aug 7;9(73):1892-7 [22337631] Food Microbiol. 2013 Dec;36(2):416-25 [24010624] PLoS One. 2014;9(4):e94254 [24718659] Appl Environ Microbiol. 2000 Sep;66(9):3828-34 [10966397] J Mol Microbiol Biotechnol. 2001 Jan;3(1):103-12 [11200222] J Am Soc Mass Spectrom. 2002 Feb;13(2):118-28 [11838015] Anal Chem. 1973 Mar;45(3):587-90 [4586927] Anal Chem. 1987 Dec 1;59(23):2806-9 [3434808] Epidemiol Infect. 1991 Aug;107(1):127-32 [1879479] J Hosp Infect. 1991 Oct;19(2):137-40 [1684606] Tubercle. 1991 Sep;72(3):206-9 [1771680] J Clin Pathol. 1992 Apr;45(4):355-7 [1577977] Int J Food Microbiol. 1992 Sep;17(1):57-66 [1476868] Nihon Rinsho. 1994 Feb;52(2):355-8 [8126885] Rapid Commun Mass Spectrom. 1996;10(10):1227-32 [8759332] Anal Chem. 1996 Sep 1;68(17):2805-10 [8794917] Rapid Commun Mass Spectrom. 1996;10(15):1992-6 [9004531] Anal Chem. 1999 Jul 15;71(14):2732-8 [10424165] Anal Chem. 1999 Aug 1;71(15):3226-30 [10450164] Anal Chem. 2005 Apr 15;77(8):2297-302 [15828760] Chem Commun (Camb). 2007 Feb 28;(8):807-9 [17308638] JAMA. 2008 Mar 19;299(11):1335-44 [18349094] Rapid Commun Mass Spectrom. 2008 Sep;22(18):2791-8 [18697232] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/rcm.7299 ER - TY - JOUR T1 - An improved methodology of asymmetric flow field flow fractionation hyphenated with inductively coupled mass spectrometry for the determination of size distribution of gold nanoparticles in dietary supplements. AN - 1727985862; 26456512 AB - Engineered nanoparticles are available in large numbers of commercial products claiming various health benefits. Nanoparticle absorption, distribution, metabolism, excretion, and toxicity in a biological system are dependent on particle size, thus the determination of size and size distribution is essential for full characterization. Number based average size and size distribution is a major parameter for full characterization of the nanoparticle. In the case of polydispersed samples, large numbers of particles are needed to obtain accurate size distribution data. Herein, we report a rapid methodology, demonstrating improved nanoparticle recovery and excellent size resolution, for the characterization of gold nanoparticles in dietary supplements using asymmetric flow field flow fractionation coupled with visible absorption spectrometry and inductively coupled plasma mass spectrometry. A linear relationship between gold nanoparticle size and retention times was observed, and used for characterization of unknown samples. The particle size results from unknown samples were compared to results from traditional size analysis by transmission electron microscopy, and found to have less than a 5% deviation in size for unknown product over the size range from 7 to 30 nm. Published by Elsevier B.V. JF - Journal of chromatography. A AU - Mudalige, Thilak K AU - Qu, Haiou AU - Linder, Sean W AD - Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States. Electronic address: Thilak.Mudalige@fda.hhs.gov. ; Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States. ; Office of Regulatory Affairs, Arkansas Regional Laboratory, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, United States. Electronic address: Sean.Linder@fda.hhs.gov. Y1 - 2015/11/13/ PY - 2015 DA - 2015 Nov 13 SP - 92 EP - 97 VL - 1420 KW - Gold KW - 7440-57-5 KW - Index Medicus KW - Asymmetric flow field flow fractionation KW - Dietary supplements KW - Inductively coupled plasma mass spectrometry KW - Nanoparticles KW - Size distribution KW - Microscopy, Electron, Transmission -- methods KW - Particle Size KW - Humans KW - Mass Spectrometry -- instrumentation KW - Metal Nanoparticles -- chemistry KW - Metal Nanoparticles -- ultrastructure KW - Mass Spectrometry -- methods KW - Fractionation, Field Flow -- methods KW - Gold -- chemistry KW - Dietary Supplements -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727985862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+A&rft.atitle=An+improved+methodology+of+asymmetric+flow+field+flow+fractionation+hyphenated+with+inductively+coupled+mass+spectrometry+for+the+determination+of+size+distribution+of+gold+nanoparticles+in+dietary+supplements.&rft.au=Mudalige%2C+Thilak+K%3BQu%2C+Haiou%3BLinder%2C+Sean+W&rft.aulast=Mudalige&rft.aufirst=Thilak&rft.date=2015-11-13&rft.volume=1420&rft.issue=&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+A&rft.issn=1873-3778&rft_id=info:doi/10.1016%2Fj.chroma.2015.09.091 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-17 N1 - Date created - 2015-10-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chroma.2015.09.091 ER - TY - JOUR T1 - Point-of-care management of urogenital Chlamydia trachomatis via Gram-stained smear analysis in male high-risk patients. Diagnostic accuracy and cost-effectiveness before and after changing the screening indication at the STI Clinic in Amsterdam AN - 1827886352; PQ0003423028 AB - ObjectivesTo measure the effect of changing the point-of-care (POC) testing algorithm of urogenital chlamydia for all male high-risk patients to those with only symptoms with respect to: diagnostic accuracy, loss to follow-up, correctly managed consultations and costs.MethodsRetrospective comparison of the diagnostic accuracy and cost-effectiveness of Gram-stained urethral smear analysis for the POC management of urogenital Chlamydia trachomatis infections. Between 2008 and 2009 Gram-stained urethral smear analysis was offered to all men irrespective of symptoms; between 2010 and 2011 only to those with symptoms. The Aptima CT assay was the reference diagnostic test.ResultsThe number of examined Gram-stained smears in the two periods was respectively 7185 (2008-2009 period) and 18852 (2010-2011 period). The sensitivity of the Gram stain analysis was respectively 83.8% (95% CI 81.2% to 86.1%) and 91.0% (95% CI 89.5% to 92.3%) (p<0.001). The specificity was respectively 74.1% (95% CI 73.0% to 75.2%) and 53.1% (95% CI 51.8% to 54.4%) (p<0.001). The positive predictive value was low in both periods, respectively 31.7% (95% CI 29.8% to 33.6%) and 35.6% (95% CI 34.1% to 37.1%) (p=0.002), whereas the negative predictive value was high, respectively 97.0% (95% CI 96.4% to 97.4%) and 95.4% (95% CI 94.6% to 96.1%) (p=0.002). The loss to follow-up rate between 2008-2009 and 2010-2011 was, respectively, 1.8% (95% CI 1.0% to 2.9%) vs 2.3% (95% CI 1.7% to 3.0%) (p=0.36). There was a small difference in overtreatment, 68.0% (95% CI 66.0% to 69.8%) vs 64.1% (95% CI 62.6% to 65.5%) (p=0.001). The cost per correctly managed consultation was 14.3% lower in the 2010-2011 period ([Euro94.31 vs [Euro80.82). The percentage of delayed treated infections was significantly lower in the 2008-2009 period (10.5%) compared with the 2010-2011 period (22.8%) (p<0.001).ConclusionsWith a high sensitivity in male high-risk patients, the Gram-stained urethral smear is a useful POC test to detect urogenital C. trachomatis. When offered only to men with urogenital symptoms the specificity decreases but the cost per correctly managed consultation is reduced with 14.3% without a significant difference in loss to follow-up but with a significantly higher rate of delayed treatment. JF - Sexually Transmitted Infections AU - Bartelsman, M AU - van Rooijen, M S AU - Alba, S AU - Vaughan, K AU - Faber, W R AU - Straetemans, M AU - de Vries, H J C AD - STI Outpatient Clinic, Public Health Service of Amsterdam (GGD Amsterdam), , Amsterdam, The Netherlands Y1 - 2015/11/08/ PY - 2015 DA - 2015 Nov 08 SP - 479 EP - 484 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 91 IS - 7 SN - 1368-4973, 1368-4973 KW - Microbiology Abstracts B: Bacteriology KW - COST-EFFECTIVENESS KW - TESTING KW - CHLAMYDIA TRACHOMATIS KW - Gram stain KW - Algorithms KW - Chlamydia trachomatis KW - Risk groups KW - Infection KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827886352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=Point-of-care+management+of+urogenital+Chlamydia+trachomatis+via+Gram-stained+smear+analysis+in+male+high-risk+patients.+Diagnostic+accuracy+and+cost-effectiveness+before+and+after+changing+the+screening+indication+at+the+STI+Clinic+in+Amsterdam&rft.au=Bartelsman%2C+M%3Bvan+Rooijen%2C+M+S%3BAlba%2C+S%3BVaughan%2C+K%3BFaber%2C+W+R%3BStraetemans%2C+M%3Bde+Vries%2C+H+J+C&rft.aulast=Bartelsman&rft.aufirst=M&rft.date=2015-11-08&rft.volume=91&rft.issue=7&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/10.1136%2Fsextrans-2014-051941 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Gram stain; Algorithms; Risk groups; Infection; Chlamydia trachomatis DO - http://dx.doi.org/10.1136/sextrans-2014-051941 ER - TY - JOUR T1 - High-resolution multilocus sequence typing reveals novel urogenital Chlamydia trachomatis strains in women in Mopani district, South Africa AN - 1827886365; PQ0003422988 AB - ObjectivesRecently, we reported a high prevalence (16%) of urogenital Chlamydia trachomatis infections among women in a rural setting in South Africa. Molecular epidemiological studies on C. trachomatis infections could provide insights into the characteristics of this epidemic, yet such data are not available. The objective of this study was therefore to assess the distribution of C. trachomatis strains among women from a South African rural community, the Mopani district, and to compare it with strains from Amsterdam, the Netherlands.MethodsHigh-resolution multilocus sequence typing (hr-MLST) was used to study urogenital C. trachomatis infections in women visiting primary healthcare facilities across rural Mopani District in Limpopo Province, South Africa. Sequence types (STs) were compared with 100 strains from women visiting the sexually transmitted infection clinic in Amsterdam, the Netherlands.ResultsFull hr-MLST data were obtained for C. trachomatis infection in 43 women from Mopani district. Using the complete hr-MLST profile of all 43 women from Mopani district, 26 STs could be identified, of which 18 (69%) were novel to the hr-MLST database. The remaining STs clustered together with strains from Amsterdam.ConclusionsHr-MLST data revealed a diverse molecular epidemiology with novel STs and a specific cluster for the Mopani district. Also C. trachomatis types that occur worldwide were detected. JF - Sexually Transmitted Infections AU - Versteeg, Bart AU - Dubbink, Jan Henk AU - Bruisten, Sylvia M AU - McIntyre, James A AU - Morre, Servaas A AU - Peters, Remco PH AD - Public Health Laboratory, Cluster Infectious Diseases, Public Health Service Amsterdam, , Amsterdam, The Netherlands Y1 - 2015/11/06/ PY - 2015 DA - 2015 Nov 06 SP - 510 EP - 512 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 91 IS - 7 SN - 1368-4973, 1368-4973 KW - Microbiology Abstracts B: Bacteriology KW - CHLAMYDIA TRACHOMATIS KW - CHLAMYDIA INFECTION KW - BACTERIAL TYPING KW - Databases KW - Data processing KW - Epidemics KW - Epidemiology KW - Chlamydia trachomatis KW - Infection KW - multilocus sequence typing KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827886365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=High-resolution+multilocus+sequence+typing+reveals+novel+urogenital+Chlamydia+trachomatis+strains+in+women+in+Mopani+district%2C+South+Africa&rft.au=Versteeg%2C+Bart%3BDubbink%2C+Jan+Henk%3BBruisten%2C+Sylvia+M%3BMcIntyre%2C+James+A%3BMorre%2C+Servaas+A%3BPeters%2C+Remco+PH&rft.aulast=Versteeg&rft.aufirst=Bart&rft.date=2015-11-06&rft.volume=91&rft.issue=7&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/10.1136%2Fsextrans-2014-051998 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Databases; Epidemics; Data processing; Epidemiology; Infection; multilocus sequence typing; Chlamydia trachomatis DO - http://dx.doi.org/10.1136/sextrans-2014-051998 ER - TY - JOUR T1 - A multi-omic analysis of human naïve CD4+ T cells. AN - 1731791832; 26542228 AB - Cellular function and diversity are orchestrated by complex interactions of fundamental biomolecules including DNA, RNA and proteins. Technological advances in genomics, epigenomics, transcriptomics and proteomics have enabled massively parallel and unbiased measurements. Such high-throughput technologies have been extensively used to carry out broad, unbiased studies, particularly in the context of human diseases. Nevertheless, a unified analysis of the genome, epigenome, transcriptome and proteome of a single human cell type to obtain a coherent view of the complex interplay between various biomolecules has not yet been undertaken. Here, we report the first multi-omic analysis of human primary naïve CD4+ T cells isolated from a single individual. Integrating multi-omics datasets allowed us to investigate genome-wide methylation and its effect on mRNA/protein expression patterns, extent of RNA editing under normal physiological conditions and allele specific expression in naïve CD4+ T cells. In addition, we carried out a multi-omic comparative analysis of naïve with primary resting memory CD4+ T cells to identify molecular changes underlying T cell differentiation. This analysis provided mechanistic insights into how several molecules involved in T cell receptor signaling are regulated at the DNA, RNA and protein levels. Phosphoproteomics revealed downstream signaling events that regulate these two cellular states. Availability of multi-omics data from an identical genetic background also allowed us to employ novel proteogenomics approaches to identify individual-specific variants and putative novel protein coding regions in the human genome. We utilized multiple high-throughput technologies to derive a comprehensive profile of two primary human cell types, naïve CD4+ T cells and memory CD4+ T cells, from a single donor. Through vertical as well as horizontal integration of whole genome sequencing, methylation arrays, RNA-Seq, miRNA-Seq, proteomics, and phosphoproteomics, we derived an integrated and comparative map of these two closely related immune cells and identified potential molecular effectors of immune cell differentiation following antigen encounter. JF - BMC systems biology AU - Mitchell, Christopher J AU - Getnet, Derese AU - Kim, Min-Sik AU - Manda, Srikanth S AU - Kumar, Praveen AU - Huang, Tai-Chung AU - Pinto, Sneha M AU - Nirujogi, Raja Sekhar AU - Iwasaki, Mio AU - Shaw, Patrick G AU - Wu, Xinyan AU - Zhong, Jun AU - Chaerkady, Raghothama AU - Marimuthu, Arivusudar AU - Muthusamy, Babylakshmi AU - Sahasrabuddhe, Nandini A AU - Raju, Rajesh AU - Bowman, Caitlyn AU - Danilova, Ludmila AU - Cutler, Jevon AU - Kelkar, Dhanashree S AU - Drake, Charles G AU - Prasad, T S Keshava AU - Marchionni, Luigi AU - Murakami, Peter N AU - Scott, Alan F AU - Shi, Leming AU - Thierry-Mieg, Jean AU - Thierry-Mieg, Danielle AU - Irizarry, Rafael AU - Cope, Leslie AU - Ishihama, Yasushi AU - Wang, Charles AU - Gowda, Harsha AU - Pandey, Akhilesh AD - McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. cmitch48@jhmi.edu. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. dgetnet1@jhmi.edu. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mskim@jhmi.edu. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. srikanth@ibioinformatics.org. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. praveen@ibioinformatics.org. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. huang@jhmi.edu. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. pinto@jhmi.edu. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. raja@ibioinformatics.org. ; Department of Molecular & Cellular BioAnalysis, Kyoto University, Kyoto, Japan. omio13@gmail.com. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. pshaw@jhsph.edu. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. xinyan@jhmi.edu. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jzhong@jhmi.edu. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. raghothama@jhmi.edu. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. arivusudar@ibioinformatics.org. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. babylakshmi@ibioinformatics.org. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. nandini@ibioinformatics.org. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. rajesh@ibioinformatics.org. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. cbowma14@jhmi.edu. ; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ludmila.danilova@gmail.com. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. jevon@jhmi.edu. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. dhanashree@ibioinformatics.org. ; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. cdrake@jhmi.edu. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. keshav@ibioinformatics.org. ; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. marchion@gmail.com. ; Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. pmurakam@jhsph.edu. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. afscott@jhmi.edu. ; National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA. leming.shi@fda.hhs.gov. ; National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA. mieg@ncbi.nlm.nih.gov. ; Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA, USA. rafa@jhu.edu. ; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Lcope1@jhmi.edu. ; Department of Molecular & Cellular BioAnalysis, Kyoto University, Kyoto, Japan. yishiham@pharm.kyoto-u.ac.jp. ; Center for Genomics and Division of Microbiology & Molecular Genetics, Loma Linda University, Loma Linda, CA, USA. chwang@llu.edu. ; Institute of Bioinformatics, International Tech Park, Whitefield, Bangalore, India. harsha@bioinformatics.org. ; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. pandey@jhmi.edu. Y1 - 2015/11/06/ PY - 2015 DA - 2015 Nov 06 SP - 75 VL - 9 KW - RNA, Messenger KW - 0 KW - Index Medicus KW - Genetic Variation KW - Genome, Human KW - Humans KW - Gene Expression Profiling KW - DNA Methylation KW - Phosphorylation KW - RNA, Messenger -- metabolism KW - Proteomics KW - Signal Transduction -- genetics KW - RNA Editing -- drug effects KW - Transcriptome KW - Epigenomics KW - Genomics KW - High-Throughput Nucleotide Sequencing KW - CD4-Positive T-Lymphocytes -- metabolism KW - Immunity, Innate -- physiology KW - Immunity, Innate -- genetics KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731791832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+systems+biology&rft.atitle=A+multi-omic+analysis+of+human+na%C3%AFve+CD4%2B+T+cells.&rft.au=Mitchell%2C+Christopher+J%3BGetnet%2C+Derese%3BKim%2C+Min-Sik%3BManda%2C+Srikanth+S%3BKumar%2C+Praveen%3BHuang%2C+Tai-Chung%3BPinto%2C+Sneha+M%3BNirujogi%2C+Raja+Sekhar%3BIwasaki%2C+Mio%3BShaw%2C+Patrick+G%3BWu%2C+Xinyan%3BZhong%2C+Jun%3BChaerkady%2C+Raghothama%3BMarimuthu%2C+Arivusudar%3BMuthusamy%2C+Babylakshmi%3BSahasrabuddhe%2C+Nandini+A%3BRaju%2C+Rajesh%3BBowman%2C+Caitlyn%3BDanilova%2C+Ludmila%3BCutler%2C+Jevon%3BKelkar%2C+Dhanashree+S%3BDrake%2C+Charles+G%3BPrasad%2C+T+S+Keshava%3BMarchionni%2C+Luigi%3BMurakami%2C+Peter+N%3BScott%2C+Alan+F%3BShi%2C+Leming%3BThierry-Mieg%2C+Jean%3BThierry-Mieg%2C+Danielle%3BIrizarry%2C+Rafael%3BCope%2C+Leslie%3BIshihama%2C+Yasushi%3BWang%2C+Charles%3BGowda%2C+Harsha%3BPandey%2C+Akhilesh&rft.aulast=Mitchell&rft.aufirst=Christopher&rft.date=2015-11-06&rft.volume=9&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=BMC+systems+biology&rft.issn=1752-0509&rft_id=info:doi/10.1186%2Fs12918-015-0225-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-26 N1 - Date created - 2015-11-06 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - PRJNA234019; SRA N1 - SuppNotes - Cited By: J Immunol. 2000 Sep 1;165(5):2458-64 [10946271] Trends Biochem Sci. 2001 Jan;26(1):54-61 [11165518] Nat Immunol. 2000 Jul;1(1):59-64 [10881176] Nat Rev Immunol. 2002 Aug;2(8):547-56 [12154374] J Neuropathol Exp Neurol. 2004 Apr;63(4):350-62 [15099025] RNA. 2012 Sep;18(9):1586-96 [22832026] Genome Res. 2012 Sep;22(9):1626-33 [22955975] Nature. 2012 Oct 4;490(7418):61-70 [23000897] Nat Immunol. 2012 Nov;13(11):1037-44 [23080204] Mol Cell Proteomics. 2005 Jul;4(7):873-86 [15858219] Immunity. 2005 Dec;23(6):561-74 [16356855] Cell Immunol. 2005 Sep;237(1):17-27 [16289056] Nat Protoc. 2006;1(1):139-45 [17406225] Annu Rev Immunol. 2007;25:193-219 [17129180] J Immunol. 2007 Sep 15;179(6):3689-98 [17785805] J Immunol. 2008 Jan 1;180(1):402-8 [18097041] J Biol Chem. 2008 Sep 5;283(36):24392-9 [18583339] Nucleic Acids Res. 2009 Jan;37(Database issue):D767-72 [18988627] PLoS One. 2009;4(1):e4150 [19127300] J Exp Med. 2009 Sep 28;206(10):2111-9 [19770269] J Immunol. 2009 Dec 1;183(11):7362-70 [19917688] Nat Rev Immunol. 2009 Dec;9(12):823-32 [19935802] Mol Cell Biol. 2010 Feb;30(4):922-34 [20008554] J Immunol. 1999 Jan 1;162(1):186-94 [9886385] Mol Cell Proteomics. 2005 May;4(5):637-50 [15723814] Nat Genet. 2010 Apr;42(4):295-302 [20190752] J Cell Sci. 2010 Jul 15;123(Pt 14):2375-80 [20551178] Mol Cell. 2010 Dec 10;40(5):798-809 [21145487] Brief Funct Genomics. 2011 Mar;10(2):98-107 [21436306] J Clin Invest. 2011 Mar;121(3):1191-8 [21393862] Nature. 2011 May 19;473(7347):337-42 [21593866] Mol Syst Biol. 2011;7:522 [21811232] Nat Methods. 2011;8(10):785-6 [21959131] Genome Res. 2011 Nov;21(11):1872-81 [21795387] Mol Cell Proteomics. 2011 Dec;10(12):M111.011627 [21969609] Nucleic Acids Res. 2012 Jan;40(Database issue):D302-5 [22053084] Genome Res. 2012 Jan;22(1):142-50 [21960545] Biochem Soc Trans. 2012 Feb;40(1):79-84 [22260669] J Chromatogr A. 2012 Mar 9;1228:292-7 [22078304] Science. 2012 Feb 17;335(6070):823-8 [22344438] Nat Biotechnol. 2012 Mar;30(3):253-60 [22327324] Cell. 2012 Mar 16;148(6):1293-307 [22424236] Annu Rev Biochem. 2012;81:379-405 [22439968] Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):E1629-37 [22615393] Curr Opin Biotechnol. 2012 Aug;23(4):591-7 [22169889] PLoS One. 2012;7(8):e42775 [22880103] Nature. 2014 May 29;509(7502):575-81 [24870542] J Exp Med. 1994 Apr 1;179(4):1127-35 [8145034] J Immunol. 1995 Apr 1;154(7):3062-77 [7534786] J Mol Med (Berl). 1996 Oct;74(10):589-607 [8912180] J Biol Chem. 1998 Jan 9;273(2):1144-9 [9422780] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12918-015-0225-4 ER - TY - JOUR T1 - System and Patient Barriers to Care among People Living with HIV/AIDS in Houston/Harris County, Texas AN - 1808679376; PQ0003416038 AB - In the United States, a considerable number of people diagnosed with HIV are not receiving HIV medical care due to some barriers. Using data from the Medical Monitoring Project survey of HIV medical care providers in Houston/Harris County, Texas, we assessed the HIV medical care providers' perspectives of the system and patient barriers to HIV care experienced by people living with HIV/AIDS (PLWHA). The study findings indicate that of the 14 HIV care barriers identified, only 1 system barrier and 7 patient barriers were considered of significant (P less than or equal to .05) importance, with the proportion of HIV medical care providers' agreement to these barriers ranging from 73.9% (cost of health care) to 100% (lack of social support systems and drug abuse problems). Providers' perception of important system and patient barriers varied significantly (P less than or equal to .05) by profession, race/ethnicity, and years of experience in HIV care. To improve access to and for consistent engagement in HIV care, effective intervention programs are needed to address the barriers identified especially in the context of the new health care delivery system. JF - Journal of the International Association of Providers of AIDS Care (JIAPAC) AU - Mgbere, Osaro AU - Khuwaja, Salma AU - Bell, Tanvir K AU - Rodriguez-Barradas, Maria C AU - Arafat, Raouf AU - Essien, Ekere James AU - Singh, Mamta AU - Aguilar, Jonathan AU - Roland, Eric AD - Houston Department of Health and Human Services, Office of Surveillance and Public Health Preparedness, Houston, TX, USA, osaro.mgbere@houstontx.gov Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 505 EP - 515 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 14 IS - 6 SN - 2325-9574, 2325-9574 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - HIV/AIDS KW - HIV medical care provider KW - system barrier KW - patient barrier KW - Houston/Harris County KW - Texas KW - Acquired immune deficiency syndrome KW - Data processing KW - Intervention KW - Drug abuse KW - Social interactions KW - ASW, USA, Texas KW - Health care KW - Human immunodeficiency virus KW - Perception KW - USA, Texas, Houston KW - Races KW - Ethnic groups KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808679376?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+International+Association+of+Providers+of+AIDS+Care+%28JIAPAC%29&rft.atitle=System+and+Patient+Barriers+to+Care+among+People+Living+with+HIV%2FAIDS+in+Houston%2FHarris+County%2C+Texas&rft.au=Mgbere%2C+Osaro%3BKhuwaja%2C+Salma%3BBell%2C+Tanvir+K%3BRodriguez-Barradas%2C+Maria+C%3BArafat%2C+Raouf%3BEssien%2C+Ekere+James%3BSingh%2C+Mamta%3BAguilar%2C+Jonathan%3BRoland%2C+Eric&rft.aulast=Mgbere&rft.aufirst=Osaro&rft.date=2015-11-01&rft.volume=14&rft.issue=6&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+International+Association+of+Providers+of+AIDS+Care+%28JIAPAC%29&rft.issn=23259574&rft_id=info:doi/10.1177%2F2325957414539045 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Data processing; Perception; Drug abuse; Ethnic groups; Races; Social interactions; Health care; Intervention; Human immunodeficiency virus; ASW, USA, Texas; USA, Texas, Houston DO - http://dx.doi.org/10.1177/2325957414539045 ER - TY - JOUR T1 - Assessing the effect of decentralisation of laboratory diagnosis for drug-resistant tuberculosis in Kenya AN - 1773832315; PQ0002533508 AB - SETTING: Drug susceptibility testing (DST) is recommended in Kenya to identify multidrug-resistant tuberculosis (MDR-TB) in persons registered for tuberculosis (TB) retreatment. DST is performed at a central laboratory with a two-step growth-based process and a regional laboratory with a simultaneous molecular- and growth-based process. OBJECTIVE: To compare proportions of retreatment cases who underwent DST and turnaround times for hospitals referring to the central vs. regional laboratory. DESIGN: Cases were persons registered for TB retreatment from 1 January 2012 to 31 December 2013. Records of 11 hospitals and 7 hospitals referring patients to the regional and central laboratories, respectively, were reviewed. RESULTS: Respectively 238/432 (55%) and 88/355 (25%) cases from hospitals referring to the regional and central laboratories underwent DST. The mean time from case registration to receipt of DST results and initiation of MDR-TB treatment was quicker in hospitals referring to the regional laboratory. The time required for the transportation of specimens, specimen testing and receipt of DST results at hospitals was shorter for the regional laboratory (P < 0.05). CONCLUSION: Testing was faster and more complete at hospitals referring to the regional laboratory. A comprehensive review of MDR-TB detection in Kenya is required to increase the proportion of cases receiving DST. JF - International Journal of Tuberculosis and Lung Disease AU - Sharma, A AU - Musau, S AU - Heilig, C M AU - Okumu, A O AU - Opiyo, E O AU - Basiye, F L AU - Miruka, F O AU - Kioko, J K AU - Sitienei, J K AU - Cain, K P AD - Epidemic Intelligence Service, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA, aditya.sharma@cdc.hhs.gov Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1348 EP - 1353 PB - International Union Against Tuberculosis and Lung Disease, 68 bvd Saint-Michel Paris 75006 France VL - 19 IS - 11 SN - 1027-3719, 1027-3719 KW - Microbiology Abstracts B: Bacteriology KW - decentralisation KW - laboratory testing KW - drug-resistant tuberculosis KW - Mycobacterium KW - Drug resistance KW - Lung diseases KW - Tuberculosis KW - Drugs KW - Hospitals KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773832315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Assessing+the+effect+of+decentralisation+of+laboratory+diagnosis+for+drug-resistant+tuberculosis+in+Kenya&rft.au=Sharma%2C+A%3BMusau%2C+S%3BHeilig%2C+C+M%3BOkumu%2C+A+O%3BOpiyo%2C+E+O%3BBasiye%2C+F+L%3BMiruka%2C+F+O%3BKioko%2C+J+K%3BSitienei%2C+J+K%3BCain%2C+K+P&rft.aulast=Sharma&rft.aufirst=A&rft.date=2015-11-01&rft.volume=19&rft.issue=11&rft.spage=1348&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.15.0328 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-03-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Drug resistance; Lung diseases; Tuberculosis; Drugs; Hospitals; Mycobacterium DO - http://dx.doi.org/10.5588/ijtld.15.0328 ER - TY - JOUR T1 - Bias from Differential Exposure Measurement Error in a Study of Flight Attendants AN - 1762365043; PQ0002504350 AB - BACKGROUND: Self-reported occupational exposures are often used in epidemiological studies when actual exposure measurements are unavailable, which could cause measurement error and bias study results. This study provides a numeric example of this potential bias. METHODS: A study of block hours and preterm birth was used as an illustrative example. This study included 577 flight attendants, ages 18-45 yr, who gave birth to a term (37 or greater gestational weeks) or preterm (20-36 gestational weeks) infant between 1992 and 1996. Flight attendants self-reported the number of block hours flown during the first trimester of pregnancy; the number of block hours flown during the first trimester of pregnancy was also calculated from airline records. No adjustment for confounding was performed for this illustrative example. RESULTS: Although flight attendants having term and preterm births self-reported similar hours worked during the first trimester (median 213 vs. 215 block hours), airline records showed that flight attendants having term births worked more hours than those having preterm births (median 146 vs. 104 block hours). Using self-reported block hours, there was no association between block hours and preterm birth; when using airline records, an inverse association was observed. DISCUSSION: In this example, differential measurement error from use of self-reported block hours obscured an inverse association apparent when using airline records, demonstrating the importance of accurate exposure assessment for identifying occupational risk factors for health outcomes. JF - Aerospace Medicine and Human Performance AU - Johnson, Candice Y AU - Grajewski, Barbara AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1090 Tusculum Ave., MS R-15, Cincinnati, OH 45226, cyjohnson@cdc.gov Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 990 EP - 993 PB - Aerospace Medical Association, 320 S. Henry St. Alexandria VA 22314-3579 United States VL - 86 IS - 11 SN - 2375-6314, 2375-6314 KW - Health & Safety Science Abstracts KW - block hours KW - exposure assessment KW - preterm birth KW - Age KW - Risk factors KW - Airlines KW - Human factors KW - Occupational exposure KW - Pregnancy KW - Infants KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762365043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerospace+Medicine+and+Human+Performance&rft.atitle=Bias+from+Differential+Exposure+Measurement+Error+in+a+Study+of+Flight+Attendants&rft.au=Johnson%2C+Candice+Y%3BGrajewski%2C+Barbara&rft.aulast=Johnson&rft.aufirst=Candice&rft.date=2015-11-01&rft.volume=86&rft.issue=11&rft.spage=990&rft.isbn=&rft.btitle=&rft.title=Aerospace+Medicine+and+Human+Performance&rft.issn=23756314&rft_id=info:doi/10.3357%2FAMHP.4321.2015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 6 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Age; Risk factors; Airlines; Human factors; Occupational exposure; Infants; Pregnancy DO - http://dx.doi.org/10.3357/AMHP.4321.2015 ER - TY - JOUR T1 - Simultaneous Presence of Insertion Sequence Excision Enhancer and Insertion Sequence IS629 Correlates with Increased Diversity and Virulence in Shiga Toxin-Producing Escherichia coli AN - 1751215402; PQ0002308804 AB - Although new serotypes of enterohemorrhagic Escherichia coli (EHEC) emerge constantly, the mechanisms by which these new pathogens arise and the reasons emerging serotypes tend to carry more virulence genes than other E. coli are not understood. An insertion sequence (IS) excision enhancer (IEE) was discovered in EHEC O157:H7 that promoted the excision of IS3 family members and generating various genomic deletions. One IS3 family member, IS629, actively transposes and proliferates in EHEC O157:H7 and enterotoxigenic E. coli (ETEC) O139 and O149. The simultaneous presence of the IEE and IS629 (and other IS3 family members) may be part of a system promoting not only adaptation and genome diversification in E. coli O157:H7 but also contributing to the development of pathogenicity among predominant serotypes. Prevalence comparisons of these elements in 461 strains, representing 72 different serotypes and 5 preassigned seropathotypes (SPT) A to E, showed that the presence of these two elements simultaneously was serotype specific and associated with highly pathogenic serotypes (O157 and top non-O157 Shiga toxin-producing Escherichia coli [STEC]) implicated in outbreaks and sporadic cases of human illness (SPT A and B). Serotypes lacking one or both elements were less likely to have been isolated from clinical cases. Our comparisons of IEE sequences showed sequence variations that could be divided into at least three clusters. Interestingly, the IEE sequences from O157 and the top 10 non-O157 STEC serotypes fell into clusters I and II, while less commonly isolated serotypes O5 and O174 fell into cluster III. These results suggest that IS629 and IEE elements may be acting synergistically to promote genome plasticity and genetic diversity among STEC strains, enhancing their abilities to adapt to hostile environments and rapidly take up virulence factors. JF - Journal of Clinical Microbiology AU - Toro, M AU - Rump, L V AU - Cao, G AU - Meng, J AU - Brown, E W AU - Gonzalez-Escalona, N AD - << + $0, narjol.gonzalez-escalona@fda.hhs.gov. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 3466 EP - 3473 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 11 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Serotypes KW - Adaptations KW - virulence factors KW - Genetic diversity KW - Pathogens KW - Insertion sequences KW - Virulence KW - Enhancers KW - Pathogenicity KW - Escherichia coli KW - genomics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751215402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Simultaneous+Presence+of+Insertion+Sequence+Excision+Enhancer+and+Insertion+Sequence+IS629+Correlates+with+Increased+Diversity+and+Virulence+in+Shiga+Toxin-Producing+Escherichia+coli&rft.au=Toro%2C+M%3BRump%2C+L+V%3BCao%2C+G%3BMeng%2C+J%3BBrown%2C+E+W%3BGonzalez-Escalona%2C+N&rft.aulast=Toro&rft.aufirst=M&rft.date=2015-11-01&rft.volume=53&rft.issue=11&rft.spage=3466&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01349-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 47 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Genomes; Virulence; Enhancers; Adaptations; Serotypes; Pathogenicity; virulence factors; Genetic diversity; genomics; Pathogens; Insertion sequences; Escherichia coli DO - http://dx.doi.org/10.1128/JCM.01349-15 ER - TY - JOUR T1 - Assessment of total silver and silver nanoparticle extraction from medical devices AN - 1751211820; PQ0002347189 AB - There is concern over the release of silver nanoparticles (AgNPs) from medical devices due to their potential toxicological consequences inside the body. Towards developing the exposure component of a risk assessment model, the purpose of this study was to determine the amount and physical form of silver released from medical devices. Scanning electron microscopy was used to confirm that three of five marketed medical devices contained nanosilver coatings (mean feature sizes 115-341 nm). Aqueous device extracts (water, saline and human plasma) were analyzed with inductively coupled plasma mass spectrometry, ultraviolet-visible spectroscopy, dynamic light scattering, transmission electron microscopy, and nanoparticle tracking analysis. The amount of silver extracted from the devices ranged from 1 10-1 to 1 106 ng/cm2 (conditions ranged from 37 to 50 degree C, over one hour to seven days). The results further indicated that one of the five devices (labeled MD1) released significantly more AgNPs than the other devices. This data suggests that some but not all devices that are formulated with nanosilver may release detectable levels of AgNPs upon extraction. Further work is underway to quantitate the proportion of silver released as AgNPs and to incorporate this data into a risk assessment for AgNP exposure from medical devices. JF - Food and Chemical Toxicology AU - Sussman, Eric M AU - Jayanti, Priyanka AU - Dair, Benita J AU - Casey, Brendan J AD - U.S. Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry, and Materials Science, 10903 New Hampshire Ave., Silver Spring, MD 20993, USA Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 10 EP - 19 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 85 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Medical device KW - Silver nanoparticle KW - Extraction KW - Exposure assessment KW - Risk assessment KW - Scanning electron microscopy KW - Data processing KW - Transmission electron microscopy KW - Light scattering KW - Silver KW - nanoparticles KW - Mass spectroscopy KW - Models KW - Coatings KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751211820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Assessment+of+total+silver+and+silver+nanoparticle+extraction+from+medical+devices&rft.au=Sussman%2C+Eric+M%3BJayanti%2C+Priyanka%3BDair%2C+Benita+J%3BCasey%2C+Brendan+J&rft.aulast=Sussman&rft.aufirst=Eric&rft.date=2015-11-01&rft.volume=85&rft.issue=&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2015.08.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Risk assessment; Scanning electron microscopy; Data processing; Transmission electron microscopy; Light scattering; nanoparticles; Silver; Mass spectroscopy; Coatings; Models DO - http://dx.doi.org/10.1016/j.fct.2015.08.013 ER - TY - JOUR T1 - Flow cytometry evaluation of in vitro cellular necrosis and apoptosis induced by silver nanoparticles AN - 1751209269; PQ0002347178 AB - Particles possess unique properties in the nanoscale, e.g., enhanced catalytic activity, high surface area, and light emission/absorption properties, that might result in interference with colorimetric in vitro cytotoxicity assays such as MTT, XTT or MTS. Alternatively, assays that do not use spectrophotometric detection, such as trypan blue exclusion or flow cytometry (FC) based assays, are less likely to be influenced by nanoparticle interference. The aim of this study was to evaluate FC assays to assess the cytotoxicity of three different sizes (10, 100, or 200 nm) of silver nanoparticles (AgNPs) at different mass concentrations (1, 25, or 50 ug/ml) in L-929 fibroblast cells. After 4 h and 24 h exposure, cell necrosis and apoptosis were assessed using 7-AAD and Annexin V dyes, respectively, with FC. The data indicate that cell necrosis and apoptosis in AgNP-exposed fibroblasts depends on dose, exposure time, and AgNP size. The data indicate that AgNPs produced a dose- and time-dependent decrease in cell viability; however, 10 nm AgNPs were significantly more toxic than larger-sized particles. Thus, standard FC assays can be utilized to assess apoptosis and necrosis in response to nanomaterial exposure. JF - Food and Chemical Toxicology AU - Kumar, Girish AU - Degheidy, Heba AU - Casey, Brendan J AU - Goering, Peter L AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD 20993, USA Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 45 EP - 51 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 85 SN - 0278-6915, 0278-6915 KW - Toxicology Abstracts KW - Flow cytometry KW - Nanotoxicology KW - Silver nanoparticles KW - Cytotoxicity KW - Apoptosis KW - AgNP silver nanoparticle KW - NTA nanoparticle tracking analysis KW - DLS dynamic light scattering KW - TEM transmission electron microscopy KW - FC flow cytometry KW - 7-AAD 7-Aminoactinomycin D KW - MTT 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide KW - Data processing KW - Surface area KW - Colorimetry KW - Light effects KW - Fibroblasts KW - Necrosis KW - Dyes KW - Spectrophotometry KW - Silver KW - nanoparticles KW - Annexin V KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751209269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+Chemical+Toxicology&rft.atitle=Flow+cytometry+evaluation+of+in+vitro+cellular+necrosis+and+apoptosis+induced+by+silver+nanoparticles&rft.au=Kumar%2C+Girish%3BDegheidy%2C+Heba%3BCasey%2C+Brendan+J%3BGoering%2C+Peter+L&rft.aulast=Kumar&rft.aufirst=Girish&rft.date=2015-11-01&rft.volume=85&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Food+and+Chemical+Toxicology&rft.issn=02786915&rft_id=info:doi/10.1016%2Fj.fct.2015.06.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Apoptosis; Data processing; Surface area; Colorimetry; Fibroblasts; Light effects; Flow cytometry; Necrosis; Cytotoxicity; Dyes; Spectrophotometry; nanoparticles; Silver; Annexin V DO - http://dx.doi.org/10.1016/j.fct.2015.06.012 ER - TY - JOUR T1 - Collaborative study for the characterization of a chikungunya virus RNA reference reagent for use in nucleic acid testing AN - 1746874832; PQ0002169039 AB - Background and Objectives Infections with the mosquito-borne chikungunya virus (CHIKV) can cause febrile illness or be asymptomatic. Laboratory diagnosis of CHIKV is often made with laboratory-developed nucleic acid amplification technology (NAT) assays because there are no U.S. Food and Drug Administration (FDA)-approved diagnostic or blood screening assays. We aimed to produce a well-characterized CHIKV RNA reference reagent (CHIKV-RR) for use in NAT assays. Materials and Methods A CHIKV RNA-RR consisting of cell culture-grown, heat-inactivated CHIKV diluted in human plasma was assessed by 8 laboratories in a collaborative study. The participants were asked to test the CHIKV-RR using their NAT assay(s) by qualitative testing (determination of RNA end-point by testing log and half-log dilutions followed by calculation of estimated NAT-detectable units/ml, after adjustment for the sample volume used for testing), and by quantitative testing, when available. Results Results from the testing showed that the CHIKV-RR had an estimated overall mean of 7.56 log sub(10) detectable units/ml, ranging from 6.2 log sub(10) to 8.6 log sub(10). Conclusions The Center for Biologics for Evaluation and Research/FDA CHIKV RNA-RR for NAT was established with a concentration of 7.56 log sub(10) detectable units/ml. JF - Vox Sanguinis AU - Anez, G AU - Jiang, Z AU - Heisey, DAR AU - Kerby, S AU - Rios, M AD - Office of Blood Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, MD, USA. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 312 EP - 318 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 109 IS - 4 SN - 0042-9007, 0042-9007 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Screening KW - Chikungunya virus KW - RNA viruses KW - Infection KW - Public health KW - Blood KW - Serological studies KW - nucleic acids KW - RNA KW - Aquatic insects KW - Drugs KW - Nucleic acids KW - V 22410:Animal Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746874832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vox+Sanguinis&rft.atitle=Collaborative+study+for+the+characterization+of+a+chikungunya+virus+RNA+reference+reagent+for+use+in+nucleic+acid+testing&rft.au=Anez%2C+G%3BJiang%2C+Z%3BHeisey%2C+DAR%3BKerby%2C+S%3BRios%2C+M&rft.aulast=Anez&rft.aufirst=G&rft.date=2015-11-01&rft.volume=109&rft.issue=4&rft.spage=312&rft.isbn=&rft.btitle=&rft.title=Vox+Sanguinis&rft.issn=00429007&rft_id=info:doi/10.1111%2Fvox.12297 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Screening; Blood; Serological studies; RNA; Drugs; Aquatic insects; Nucleic acids; Public health; nucleic acids; RNA viruses; Infection; Chikungunya virus DO - http://dx.doi.org/10.1111/vox.12297 ER - TY - JOUR T1 - Polymerase δ replicates both strands after homologous recombination-dependent fork restart. AN - 1735334708; 26436826 AB - To maintain genetic stability, DNA must be replicated only once per cell cycle, and replication must be completed even when individual replication forks are inactivated. Because fork inactivation is common, passive convergence of an adjacent fork is insufficient to rescue all inactive forks. Thus, eukaryotic cells have evolved homologous recombination-dependent mechanisms to restart persistent inactive forks. Completing DNA synthesis via homologous recombination-restarted replication (HoRReR) ensures cell survival, but at a cost. One such cost is increased mutagenesis because HoRReR is more error prone than canonical replication. This increased error rate implies the HoRReR mechanism is distinct from that of a canonical fork. Here we demonstrate, in Schizosaccharomyces pombe, that a DNA sequence duplicated by HoRReR during S phase is replicated semiconservatively, but both the leading and lagging strands are synthesized by DNA polymerase δ. JF - Nature structural & molecular biology AU - Miyabe, Izumi AU - Mizuno, Ken'Ichi AU - Keszthelyi, Andrea AU - Daigaku, Yasukazu AU - Skouteri, Meliti AU - Mohebi, Saed AU - Kunkel, Thomas A AU - Murray, Johanne M AU - Carr, Antony M AD - Genome Damage and Stability Centre, University of Sussex, Brighton, UK. ; Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan. ; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 932 EP - 938 VL - 22 IS - 11 KW - DNA Polymerase III KW - EC 2.7.7.- KW - Index Medicus KW - Cell Division KW - Homologous Recombination KW - Schizosaccharomyces -- genetics KW - Schizosaccharomyces -- enzymology KW - Schizosaccharomyces -- physiology KW - DNA Polymerase III -- metabolism KW - DNA Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735334708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+structural+%26+molecular+biology&rft.atitle=Polymerase+%CE%B4+replicates+both+strands+after+homologous+recombination-dependent+fork+restart.&rft.au=Miyabe%2C+Izumi%3BMizuno%2C+Ken%27Ichi%3BKeszthelyi%2C+Andrea%3BDaigaku%2C+Yasukazu%3BSkouteri%2C+Meliti%3BMohebi%2C+Saed%3BKunkel%2C+Thomas+A%3BMurray%2C+Johanne+M%3BCarr%2C+Antony+M&rft.aulast=Miyabe&rft.aufirst=Izumi&rft.date=2015-11-01&rft.volume=22&rft.issue=11&rft.spage=932&rft.isbn=&rft.btitle=&rft.title=Nature+structural+%26+molecular+biology&rft.issn=1545-9985&rft_id=info:doi/10.1038%2Fnsmb.3100 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-07 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Genet. 2013 Nov;45(11):1319-26 [24056715] Nature. 2013 Oct 17;502(7471):389-92 [24025772] Cold Spring Harb Perspect Biol. 2013 Dec;5(12):a010397 [23881940] EMBO Rep. 2000 Aug;1(2):145-50 [11265754] Nature. 2001 Aug 2;412(6846):557-61 [11484058] Genes Dev. 2003 Jan 1;17(1):64-76 [12514100] Methods Enzymol. 1991;194:795-823 [2005825] Nature. 1994 May 19;369(6477):207-12 [7910375] Mol Cell. 1999 May;3(5):679-85 [10360184] Nature. 2005 Apr 14;434(7035):864-70 [15829956] Nature. 2005 Apr 14;434(7035):907-13 [15829965] Cell. 2005 Jun 3;121(5):689-702 [15935756] Genes Dev. 2005 Aug 15;19(16):1905-19 [16103218] Nature. 2006 Nov 30;444(7119):633-7 [17136093] Nature. 2006 Nov 30;444(7119):638-42 [17136094] Nature. 2013 Oct 17;502(7471):393-6 [24025768] Mol Cell. 2015 Aug 6;59(3):462-77 [26166705] Nature. 2007 Mar 8;446(7132):153-8 [17344846] Nature. 2007 May 3;447(7140):102-5 [17410126] Nature. 2007 Jul 26;448(7152):445-51 [17597761] Genome Res. 2007 Sep;17(9):1296-303 [17675364] Genes Dev. 2007 Dec 15;21(24):3331-41 [18079179] Gene. 2008 Jan 15;407(1-2):63-74 [18054176] Genetics. 2008 Sep;180(1):27-39 [18723894] Trends Cell Biol. 2008 Nov;18(11):521-7 [18824354] Genes Dev. 2009 Feb 1;23(3):291-303 [19204116] Genes Dev. 2009 Dec 15;23(24):2876-86 [20008937] Mol Cell. 2010 Feb 26;37(4):492-502 [20188668] Mol Cell. 2010 Aug 13;39(3):346-59 [20705238] PLoS Biol. 2011;9(2):e1000594 [21347245] Cell. 2011 Apr 29;145(3):435-46 [21529715] PLoS Genet. 2011 Dec;7(12):e1002407 [22144917] Crit Rev Biochem Mol Biol. 2012 May-Jun;47(3):222-35 [22324461] Curr Opin Genet Dev. 2012 Jun;22(3):211-20 [22440479] Cancer Cell. 2012 Jul 10;22(1):106-16 [22789542] Mol Biol Cell. 2012 Aug;23(16):3240-53 [22718908] PLoS Genet. 2012;8(10):e1002976 [23093942] Nature. 2013 Jan 10;493(7431):246-9 [23178809] Hum Mol Genet. 2013 Feb 15;22(4):749-56 [23161748] Cell. 2013 Jan 31;152(3):620-32 [23352430] J Cell Biol. 2013 Mar 18;200(6):699-708 [23479741] Chromosoma. 2013 Mar;122(1-2):33-45 [23446515] Curr Opin Genet Dev. 2013 Apr;23(2):132-9 [23267817] Curr Opin Genet Dev. 2013 Jun;23(3):271-9 [23790415] Oncogene. 2013 Aug 8;32(32):3744-53 [22945645] Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13475-80 [23898170] PLoS One. 2013;8(12):e83800 [24376751] Science. 2014 Jan 3;343(6166):88-91 [24310611] J Genet. 1949 Dec;49(3):264-85 [24536673] Nat Struct Mol Biol. 2014 Aug;21(8):664-70 [24997598] Genome Res. 2014 Nov;24(11):1751-64 [25217194] Nat Commun. 2015;6:6357 [25721418] Nature. 2015 Feb 26;518(7540):502-6 [25624100] Nat Struct Mol Biol. 2015 Mar;22(3):185-91 [25622295] Nat Struct Mol Biol. 2015 Mar;22(3):192-8 [25664722] Elife. 2015;4:e04539 [25806683] J Mol Biol. 2013 Nov 29;425(23):4733-44 [23643490] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/nsmb.3100 ER - TY - JOUR T1 - Agent Orange Exposure and Monoclonal Gammopathy of Undetermined Significance: An Operation Ranch Hand Veteran Cohort Study. AN - 1733196429; 26335650 AB - Multiple myeloma has been classified as exhibiting "limited or suggestive evidence" of an association with exposure to herbicides in Vietnam War veterans. Occupational studies have shown that other pesticides (ie, insecticides, herbicides, fungicides) are associated with excess risk of multiple myeloma and its precursor state, monoclonal gammopathy of undetermined significance (MGUS); however, to our knowledge, no studies have uncovered such an association in Vietnam War veterans. To examine the relationship between MGUS and exposure to Agent Orange, including its contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), in Vietnam War veterans. This was a prospective cohort study conducted in 2013 to 2014, testing for MGUS in serum specimens collected and stored in 2002 by the Air Force Health Study (AFHS). The relevant exposure data collected by the AFHS was also used. We tested all specimens in 2013 without knowledge of the exposure status. The AFHS included former US Air Force personnel who participated in Operation Ranch Hand (Ranch Hand veterans) and other US Air Force personnel who had similar duties in Southeast Asia during the same time period (1962 to 1971) but were not involved in herbicide spray missions (comparison veterans). Agent Orange was used by the US Air Force personnel who conducted aerial spray missions of herbicides (Operation Ranch Hand) in Vietnam from 1962 to 1971. We included 479 Ranch Hand veterans and 479 comparison veterans who participated in the 2002 follow-up examination of AFHS. Agent Orange and TCDD. Serum TCDD levels were measured in 1987, 1992, 1997, and 2002. Risk of MGUS measured by prevalence, odds ratios (ORs), and 95% CIs. The 479 Ranch Hand veterans and 479 comparison veterans had similar demographic and lifestyle characteristics and medical histories. The crude prevalence of overall MGUS was 7.1% (34 of 479) in Ranch Hand veterans and 3.1% (15 of 479) in comparison veterans. This translated into a 2.4-fold increased risk for MGUS in Ranch Hand veterans than comparison veterans after adjusting for age, race, BMI in 2002, and the change in BMI between 2002 and the time of blood draw for TCDD measurement (adjusted OR, 2.37; 95% CI, 1.27-4.44; P=.007). Operation Ranch Hand veterans have a significantly increased risk of MGUS, supporting an association between Agent Orange exposure and multiple myeloma. JF - JAMA oncology AU - Landgren, Ola AU - Shim, Youn K AU - Michalek, Joel AU - Costello, Rene AU - Burton, Debra AU - Ketchum, Norma AU - Calvo, Katherine R AU - Caporaso, Neil AU - Raveche, Elizabeth AU - Middleton, Dan AU - Marti, Gerald AU - Vogt, Robert F AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland2Memorial Sloan Kettering Cancer Center, New York, New York. ; Agency for Toxic Substances and Disease Registry, Atlanta, Georgia. ; Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio. ; National Cancer Institute, National Institutes of Health, Bethesda, Maryland. ; Clinical Center, National Institutes of Health, Bethesda, Maryland. ; Department of Pathology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark. ; Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland. ; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1061 EP - 1068 VL - 1 IS - 8 KW - Biomarkers KW - 0 KW - Herbicides KW - Polychlorinated Dibenzodioxins KW - 2,4-Dichlorophenoxyacetic Acid KW - 2577AQ9262 KW - Agent Orange KW - 39277-47-9 KW - 2,4,5-Trichlorophenoxyacetic Acid KW - 9Q963S4YMX KW - Index Medicus KW - Odds Ratio KW - Humans KW - Aged KW - Risk Assessment KW - Prospective Studies KW - Aged, 80 and over KW - Logistic Models KW - Risk Factors KW - Case-Control Studies KW - Middle Aged KW - United States -- epidemiology KW - Time Factors KW - Biomarkers -- blood KW - Male KW - Prevalence KW - Multiple Myeloma -- diagnosis KW - Monoclonal Gammopathy of Undetermined Significance -- chemically induced KW - Polychlorinated Dibenzodioxins -- adverse effects KW - Monoclonal Gammopathy of Undetermined Significance -- blood KW - Monoclonal Gammopathy of Undetermined Significance -- diagnosis KW - Herbicides -- adverse effects KW - Multiple Myeloma -- chemically induced KW - Veterans Health KW - 2,4-Dichlorophenoxyacetic Acid -- adverse effects KW - 2,4,5-Trichlorophenoxyacetic Acid -- adverse effects KW - Monoclonal Gammopathy of Undetermined Significance -- epidemiology KW - Multiple Myeloma -- blood KW - Multiple Myeloma -- epidemiology KW - Vietnam Conflict KW - Occupational Exposure -- adverse effects KW - Polychlorinated Dibenzodioxins -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1733196429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA+oncology&rft.atitle=Agent+Orange+Exposure+and+Monoclonal+Gammopathy+of+Undetermined+Significance%3A+An+Operation+Ranch+Hand+Veteran+Cohort+Study.&rft.au=Landgren%2C+Ola%3BShim%2C+Youn+K%3BMichalek%2C+Joel%3BCostello%2C+Rene%3BBurton%2C+Debra%3BKetchum%2C+Norma%3BCalvo%2C+Katherine+R%3BCaporaso%2C+Neil%3BRaveche%2C+Elizabeth%3BMiddleton%2C+Dan%3BMarti%2C+Gerald%3BVogt%2C+Robert+F&rft.aulast=Landgren&rft.aufirst=Ola&rft.date=2015-11-01&rft.volume=1&rft.issue=8&rft.spage=1061&rft.isbn=&rft.btitle=&rft.title=JAMA+oncology&rft.issn=2374-2445&rft_id=info:doi/10.1001%2Fjamaoncol.2015.2938 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-29 N1 - Date created - 2015-11-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: JAMA Oncol. 2015 Nov;1(8):1035-6 [26335544] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1001/jamaoncol.2015.2938 ER - TY - JOUR T1 - A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02). AN - 1731784475; 26227279 AB - CHARM-02 is a crossover, double-blind, randomized trial to compare the safety and pharmacokinetics of three rectally applied tenofovir 1% gel candidate rectal microbicides of varying osmolalities: vaginal formulation (VF) (3111 mOsmol/kg), the reduced glycerin vaginal formulation (RGVF) (836 mOsmol/kg), and an isoosmolal rectal-specific formulation (RF) (479 mOsmol/kg). Participants (n = 9) received a single, 4 ml, radiolabeled dose of each gel twice, once with and once without simulated unprotected receptive anal intercourse (RAI). The safety, plasma tenofovir pharmacokinetics, colonic small molecule permeability, and SPECT/CT imaging of lower gastrointestinal distribution of drug and virus surrogate were assessed. There were no Grade 3 or 4 adverse events reported for any of the products. Overall, there were more Grade 2 adverse events in the VF group compared to RF (p = 0.006) and RGVF (p = 0.048). In the absence of simulated unprotected RAI, VF had up to 3.8-fold greater systemic tenofovir exposure, 26- to 234-fold higher colonic permeability of the drug surrogate, and 1.5- to 2-fold greater proximal migration in the colonic lumen, when compared to RF and RGVF. Similar trends were observed with simulated unprotected RAI, but most did not reach statistical significance. SPECT analysis showed 86% (standard deviation 19%) of the drug surrogate colocalized with the virus surrogate in the colonic lumen. There were no significant differences between the RGVF and RF formulation, with the exception of a higher plasma tenofovir concentration of RGVF in the absence of simulated unprotected RAI. VF had the most adverse events, highest plasma tenofovir concentrations, greater mucosal permeability of the drug surrogate, and most proximal colonic luminal migration compared to RF and RGVF formulations. There were no major differences between RF and RGVF formulations. Simultaneous assessment of toxicity, systemic and luminal pharmacokinetics, and colocalization of drug and viral surrogates substantially informs rectal microbicide product development. JF - AIDS research and human retroviruses AU - Hiruy, Hiwot AU - Fuchs, Edward J AU - Marzinke, Mark A AU - Bakshi, Rahul P AU - Breakey, Jennifer C AU - Aung, Wutyi S AU - Manohar, Madhuri AU - Yue, Chen AU - Caffo, Brian S AU - Du, Yong AU - Abebe, Kaleab Z AU - Spiegel, Hans M L AU - Rohan, Lisa C AU - McGowan, Ian AU - Hendrix, Craig W AD - 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland. ; 2 Department of Biostatistics, Johns Hopkins School of Public Health , Baltimore, Maryland. ; 3 Department of Radiology, Johns Hopkins School of Medicine , Baltimore, Maryland. ; 4 Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania. ; 5 HJF-DAIDS, a Division of The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health , Department of Health and Human Services, Bethesda, Maryland. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1098 EP - 1108 VL - 31 IS - 11 KW - Anti-HIV Agents KW - 0 KW - Gels KW - Tenofovir KW - 99YXE507IL KW - Index Medicus KW - AIDS/HIV KW - Unsafe Sex KW - Double-Blind Method KW - Humans KW - Drug-Related Side Effects and Adverse Reactions -- pathology KW - Adult KW - Drug-Related Side Effects and Adverse Reactions -- epidemiology KW - Cross-Over Studies KW - Middle Aged KW - Administration, Rectal KW - Plasma -- chemistry KW - Male KW - Gels -- pharmacokinetics KW - Anti-HIV Agents -- pharmacokinetics KW - Tenofovir -- adverse effects KW - HIV Infections -- transmission KW - Gels -- adverse effects KW - HIV Infections -- prevention & control KW - Gels -- administration & dosage KW - Tenofovir -- pharmacokinetics KW - Anti-HIV Agents -- adverse effects KW - Anti-HIV Agents -- administration & dosage KW - Tenofovir -- administration & dosage KW - Disease Transmission, Infectious -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731784475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=A+Phase+1+Randomized%2C+Blinded+Comparison+of+the+Pharmacokinetics+and+Colonic+Distribution+of+Three+Candidate+Rectal+Microbicide+Formulations+of+Tenofovir+1%25+Gel+with+Simulated+Unprotected+Sex+%28CHARM-02%29.&rft.au=Hiruy%2C+Hiwot%3BFuchs%2C+Edward+J%3BMarzinke%2C+Mark+A%3BBakshi%2C+Rahul+P%3BBreakey%2C+Jennifer+C%3BAung%2C+Wutyi+S%3BManohar%2C+Madhuri%3BYue%2C+Chen%3BCaffo%2C+Brian+S%3BDu%2C+Yong%3BAbebe%2C+Kaleab+Z%3BSpiegel%2C+Hans+M+L%3BRohan%2C+Lisa+C%3BMcGowan%2C+Ian%3BHendrix%2C+Craig+W&rft.aulast=Hiruy&rft.aufirst=Hiwot&rft.date=2015-11-01&rft.volume=31&rft.issue=11&rft.spage=1098&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=1931-8405&rft_id=info:doi/10.1089%2FAID.2015.0098 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-12 N1 - Date created - 2015-11-07 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT01575418; ClinicalTrials.gov N1 - SuppNotes - Cited By: Biomaterials. 2013 Sep;34(28):6922-9 [23769419] Br J Clin Pharmacol. 2012 Dec;74(6):1013-22 [22404308] AIDS Res Hum Retroviruses. 2013 Nov;29(11):1487-95 [23885722] AIDS. 2013 Nov 13;27(17):2665-78 [23842129] J Nucl Cardiol. 2014 Apr;21(2):329-40 [24366822] Pharm Weekbl Sci. 1989 Feb 24;11(1):9-12 [2540479] J Infect Dis. 2007 Mar 1;195(5):703-10 [17262713] Clin Pharmacol Ther. 2008 Jan;83(1):97-105 [17507921] Med Phys. 2009 Jun;36(6):2021-33 [19610291] Lancet Infect Dis. 2010 Jul;10(7):479-88 [20610330] Science. 2010 Sep 3;329(5996):1168-74 [20643915] Sex Transm Infect. 2012 Dec;88(8):574-80 [22750885] PLoS One. 2013;8(1):e55013 [23383037] PLoS One. 2013;8(4):e60147 [23573238] J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):221-7 [23406978] AIDS. 2013 Mar 13;27(5):825-32 [23169330] J Acquir Immune Defic Syndr. 2013 Apr 15;62(5):584-9 [23334505] Lancet. 2013 Jun 15;381(9883):2083-90 [23769234] N Engl J Med. 2010 Dec 30;363(27):2587-99 [21091279] J Acquir Immune Defic Syndr. 2011 May 1;57(1):77-87 [21297479] PLoS One. 2012;7(5):e38143 [22693590] Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Apr;33(4):368-73 [22781407] N Engl J Med. 2012 Aug 2;367(5):399-410 [22784037] N Engl J Med. 2012 Aug 2;367(5):423-34 [22784038] AIDS Res Hum Retroviruses. 2015 Nov;31(11):1089-97 [26066390] PLoS One. 2015;10(5):e0125363 [25942472] PLoS One. 2012;7(8):e43071 [22937013] Curr Opin HIV AIDS. 2012 Nov;7(6):498-504 [22964888] AIDS Res Hum Retroviruses. 2012 Nov;28(11):1412-21 [22943559] AIDS Res Hum Retroviruses. 2013 Nov;29(11):1443-50 [23600365] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1089/AID.2015.0098 ER - TY - JOUR T1 - Interweaving Knowledge Resources to Address Complex Environmental Health Challenges. AN - 1730020209; 25910282 AB - Complex problems do not respect academic disciplinary boundaries. Environmental health research is complex and often moves beyond these boundaries, integrating diverse knowledge resources to solve such challenges. Here we describe an evolving paradigm for interweaving approaches that integrates widely diverse resources outside of traditional academic environments in full partnerships of mutual respect and understanding. We demonstrate that scientists, social scientists, and engineers can work with government agencies, industry, and communities to interweave their expertise into metaphorical knowledge fabrics to share understanding, resources, and enthusiasm. Our goal is to acknowledge and validate how interweaving research approaches can contribute to research-driven, solution-oriented problem solving in environmental health, and to inspire more members of the environmental health community to consider this approach. The National Institutes of Health's National Institute of Environmental Health Sciences Superfund Research Program (SRP), as mandated by Congress, has evolved to become a program that reaches across a wide range of knowledge resources. SRP fosters interweaving multiple knowledge resources to develop innovative multidirectional partnerships for research and training. Here we describe examples of how motivation, ideas, knowledge, and expertise from different people, institutions, and agencies can integrate to tackle challenges that can be as complex as the resources they bring to bear on it. By providing structure for interweaving science with its stakeholders, we are better able to leverage resources, increase potential for innovation, and proactively ensure a more fully developed spectrum of beneficial outcomes of research investments. Anderson BE, Naujokas MF, Suk WA. 2015. Interweaving knowledge resources to address complex environmental health challenges. Environ Health Perspect 123:1095-1099; http://dx.doi.org/10.1289/ehp.1409525. JF - Environmental health perspectives AU - Anderson, Beth Ellen AU - Naujokas, Marisa F AU - Suk, William A AD - Superfund Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1095 EP - 1099 VL - 123 IS - 11 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - United States KW - Population Groups KW - Cooperative Behavior KW - Humans KW - Universities KW - Environmental Pollution -- prevention & control KW - National Institute of Environmental Health Sciences (U.S.) KW - Environmental Health -- methods KW - Environmental Pollution -- adverse effects KW - Community Participation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1730020209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Interweaving+Knowledge+Resources+to+Address+Complex+Environmental+Health+Challenges.&rft.au=Anderson%2C+Beth+Ellen%3BNaujokas%2C+Marisa+F%3BSuk%2C+William+A&rft.aulast=Anderson&rft.aufirst=Beth&rft.date=2015-11-01&rft.volume=123&rft.issue=11&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1409525 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-26 N1 - Date created - 2015-11-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2002 Apr;110 Suppl 2:155-9 [11929724] Sci Total Environ. 2015 May 1;514:170-7 [25659315] Environ Sci Technol. 2008 Jul 1;42(13):4655-62 [18677987] Nature. 2010 Feb 18;463(7283):876 [20164899] Am J Public Health. 2010 Apr 1;100 Suppl 1:S19-24 [20147662] New Solut. 2010;20(1):49-72 [20359991] Environ Int. 2012 Jan;38(1):10-6 [21982028] Environ Health Perspect. 2012 Jan;120(1):6-10 [21890450] Environ Sci Technol. 2012 Jan 17;46(2):1019-27 [22191663] Environ Health Perspect. 2012 Mar;120(3):326-31 [22147336] Environ Health Perspect. 2012 Jul;120(7):a261-2 [22759358] Environ Sci Technol. 2013 Mar 19;47(6):2457-70 [23360069] Sci Total Environ. 2013 Jun 1;454-455:373-82 [23562690] J Health Soc Behav. 2013 Jun;54(2):145-64 [23598897] Chem Res Toxicol. 2013 Jun 17;26(6):853-5 [23713983] Environ Sci Technol. 2013;47(21):11985-92 [24083557] J Agric Food Chem. 2012 Jul 11;60(27):6899-906 [22690788] Sci Total Environ. 2014 Nov 1;497-498:651-64 [25173762] Sci Total Environ. 2015 Feb 1;505:694-703 [25461072] Am J Prev Med. 2008 Aug;35(2 Suppl):S116-23 [18619391] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1409525 ER - TY - JOUR T1 - Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment. AN - 1729352907; 26188115 AB - 2-Phenoxyethanol (PhE) has been shown to induce hepatotoxicity, renal toxicity, and hemolysis at dosages ≥ 400 mg/kg/day in subchronic and chronic studies in multiple species. To reduce uncertainty associated with interspecies extrapolations and to evaluate the margin of exposure (MOE) for use of PhE in cosmetics and baby products, a physiologically-based pharmacokinetic (PBPK) model of PhE and its metabolite 2-phenoxyacetic acid (PhAA) was developed. The PBPK model incorporated key kinetic processes describing the absorption, distribution, metabolism and excretion of PhE and PhAA following oral and dermal exposures. Simulations of repeat dose rat studies facilitated the selection of systemic AUC as the appropriate dose metric for evaluating internal exposures to PhE and PhAA in rats and humans. Use of the PBPK model resulted in refinement of the total default UF for extrapolation of the animal data to humans from 100 to 25. Based on very conservative assumptions for product composition and aggregate product use, model-predicted exposures to PhE and PhAA resulting from adult and infant exposures to cosmetic products are significantly below the internal dose of PhE observed at the NOAEL dose in rats. Calculated MOEs for all exposure scenarios were above the PBPK-refined UF of 25. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Troutman, John A AU - Rick, David L AU - Stuard, Sharon B AU - Fisher, Jeffrey AU - Bartels, Michael J AD - Central Product Safety, The Procter & Gamble Company, Cincinnati, OH, USA. Electronic address: troutman.ja@pg.com. ; Toxicology & Environmental Research & Consulting, The Dow Chemical Company, Midland, MI, USA. Electronic address: LRick@dow.com. ; Central Product Safety, The Procter & Gamble Company, Cincinnati, OH, USA. Electronic address: stuard.sb@pg.com. ; National Center for Toxicological Research, Food & Drug Administration, Jefferson, AR, USA. Electronic address: jeffrey.fisher@fda.hhs.gov. ; Toxicology & Environmental Research & Consulting, The Dow Chemical Company, Midland, MI, USA. Electronic address: MJBartels@dow.com. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 530 EP - 543 VL - 73 IS - 2 KW - Acetates KW - 0 KW - Ethylene Glycols KW - phenoxyacetic acid KW - 122-59-8 KW - phenoxyethanol KW - HIE492ZZ3T KW - Index Medicus KW - Ethylene glycol phenyl ether KW - PBPK KW - Toxicokinetics KW - Dosimetry KW - Uncertainty factors KW - Pharmacokinetics KW - Rats KW - Animals KW - Organ Size -- physiology KW - Dose-Response Relationship, Drug KW - Humans KW - Body Weight -- drug effects KW - Body Weight -- physiology KW - Risk Assessment -- methods KW - Species Specificity KW - Organ Size -- drug effects KW - Uncertainty KW - Ethylene Glycols -- toxicity KW - Acetates -- metabolism KW - Models, Biological KW - Acetates -- toxicity KW - Ethylene Glycols -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1729352907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Development+of+a+physiologically-based+pharmacokinetic+model+of+2-phenoxyethanol+and+its+metabolite+phenoxyacetic+acid+in+rats+and+humans+to+address+toxicokinetic+uncertainty+in+risk+assessment.&rft.au=Troutman%2C+John+A%3BRick%2C+David+L%3BStuard%2C+Sharon+B%3BFisher%2C+Jeffrey%3BBartels%2C+Michael+J&rft.aulast=Troutman&rft.aufirst=John&rft.date=2015-11-01&rft.volume=73&rft.issue=2&rft.spage=530&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-18 N1 - Date created - 2015-11-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.07.012 ER - TY - CONF T1 - RNAi technologies in agricultural biotechnology: The Toxicology Forum 40th Annual Summer Meeting. AN - 1729351839; 26361858 AB - During the 40th Annual Meeting of The Toxicology Forum, the current and potential future science, regulations, and politics of agricultural biotechnology were presented and discussed. The meeting session described herein focused on the technology of RNA interference (RNAi) in agriculture. The general process by which RNAi works, currently registered RNAi-based plant traits, example RNAi-based traits in development, potential use of double stranded RNA (dsRNA) as topically applied pesticide active ingredients, research related to the safety of RNAi, biological barriers to ingested dsRNA, recent regulatory RNAi science reviews, and regulatory considerations related to the use of RNAi in agriculture were discussed. Participants generally agreed that the current regulatory framework is robust and appropriate for evaluating the safety of RNAi employed in agricultural biotechnology and were also supportive of the use of RNAi to develop improved crop traits. However, as with any emerging technology, the potential range of future products, potential future regulatory frameworks, and public acceptance of the technology will continue to evolve. As such, continuing dialogue was encouraged to promote education of consumers and science-based regulations. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Sherman, James H AU - Munyikwa, Tichafa AU - Chan, Stephen Y AU - Petrick, Jay S AU - Witwer, Kenneth W AU - Choudhuri, Supratim Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 671 EP - 680 VL - 73 IS - 2 KW - RNA, Plant KW - 0 KW - Index Medicus KW - Agriculture KW - Toxicology Forum KW - GMO KW - RNAi KW - Biotechnology KW - dsRNA KW - Animals KW - Humans KW - Agriculture -- trends KW - Agriculture -- methods KW - Biotechnology -- trends KW - Plants, Genetically Modified -- genetics KW - RNA, Plant -- genetics KW - RNA Interference -- physiology KW - Crops, Agricultural -- genetics KW - Biotechnology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1729351839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=RNAi+technologies+in+agricultural+biotechnology%3A+The+Toxicology+Forum+40th+Annual+Summer+Meeting.&rft.au=Sherman%2C+James+H%3BMunyikwa%2C+Tichafa%3BChan%2C+Stephen+Y%3BPetrick%2C+Jay+S%3BWitwer%2C+Kenneth+W%3BChoudhuri%2C+Supratim&rft.aulast=Sherman&rft.aufirst=James&rft.date=2015-11-01&rft.volume=73&rft.issue=2&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-18 N1 - Date created - 2015-11-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.09.001 ER - TY - JOUR T1 - Influence of radiation quality on mouse chromosome 2 deletions in radiation-induced acute myeloid leukaemia. AN - 1729348760; 26520372 AB - Leukaemia is the prevailing neoplastic disorder of the hematopoietic system. Epidemiological analyses of the survivors of the Japanese atomic bombings show that exposure to ionising radiation (IR) can cause leukaemia. Although a clear association between radiation exposure and leukaemia development is acknowledged, the underlying mechanisms remain incompletely understood. A hemizygous deletion on mouse chromosome 2 (del2) is a common feature in several mouse strains susceptible to radiation-induced acute myeloid leukaemia (rAML). The deletion is an early event detectable 24h after exposure in bone marrow cells. Ultimately, 15-25% of exposed animals develop AML with 80-90% of cases carrying del2. Molecular mapping of leukaemic cell genomes identified a minimal deleted region (MDR) on chromosome 2 (chr2) in which a tumour suppressor gene, Sfpi1 is located, encoding the transcription factor PU.1, essential in haematopoiesis. The remaining copy of Sfpi1 has a point mutation in the coding sequence for the DNA-binding domain of the protein in 70% of rAML, which alters a single CpG sequence in the codon for arginine residue R235. In order to identify chr2 deletions and Sfpi.1/PU.1 loss, we performed array comparative genomic hybridization (aCGH) on a unique panel of 79rAMLs. Using a custom made CGH array specifically designed for mouse chr2, we analysed at unprecedentedly high resolution (1.4M array- 148bp resolution) the size of the MDR in low LET and high-LET induced rAMLs (32 X-ray- and 47 neutron-induced). Sequencing of Sfpi1/PU.1DNA binding domain identified the presence of R235 point mutations, showing no influence of radiation quality on R235 type or frequency. We identified for the first time rAML cases with complex del2 in a subset of neutron-induced AMLs. This study allowed us to re-define the MDR to a much smaller 5.5Mb region (still including Sfpi1/PU.1), identical regardless of radiation quality. Crown Copyright © 2015. Published by Elsevier B.V. All rights reserved. JF - Mutation research. Genetic toxicology and environmental mutagenesis AU - Brown, Natalie AU - Finnon, Rosemary AU - Manning, Grainne AU - Bouffler, Simon AU - Badie, Christophe AD - Biological Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 ORQ, UK. ; Biological Effects Department, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxfordshire OX11 ORQ, UK. Electronic address: Christophe.Badie@phe.gov.uk. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 48 EP - 54 VL - 793 KW - Proto-Oncogene Proteins KW - 0 KW - Trans-Activators KW - proto-oncogene protein Spi-1 KW - Index Medicus KW - Radiation KW - Mouse model KW - Myeloid leukemia KW - aCGH KW - Chromosome deletion KW - Sfpi1/PU.1 KW - Neutrons KW - Animals KW - X-Rays KW - Comparative Genomic Hybridization KW - Point Mutation KW - Mice KW - Male KW - Female KW - Chromosome Deletion KW - Trans-Activators -- genetics KW - Leukemia, Myeloid, Acute -- genetics KW - Chromosomes, Mammalian -- genetics KW - Leukemia, Radiation-Induced -- genetics KW - Leukemia, Myeloid, Acute -- etiology KW - Leukemia, Radiation-Induced -- veterinary KW - Leukemia, Myeloid, Acute -- veterinary KW - Proto-Oncogene Proteins -- genetics KW - Chromosomes, Mammalian -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1729348760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research.+Genetic+toxicology+and+environmental+mutagenesis&rft.atitle=Influence+of+radiation+quality+on+mouse+chromosome+2+deletions+in+radiation-induced+acute+myeloid+leukaemia.&rft.au=Brown%2C+Natalie%3BFinnon%2C+Rosemary%3BManning%2C+Grainne%3BBouffler%2C+Simon%3BBadie%2C+Christophe&rft.aulast=Brown&rft.aufirst=Natalie&rft.date=2015-11-01&rft.volume=793&rft.issue=&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Mutation+research.+Genetic+toxicology+and+environmental+mutagenesis&rft.issn=1879-3592&rft_id=info:doi/10.1016%2Fj.mrgentox.2015.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-09 N1 - Date created - 2015-11-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.mrgentox.2015.07.012 ER - TY - JOUR T1 - The role of haplotype in 15q25.1 locus in lung cancer risk: results of scanning chromosome 15. AN - 1728674496; 26282330 AB - The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case-control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case-control study with 2983 lung cancer patients and 3553 healthy controls of European ancestry for replication. Sliding window haplotype analysis within chromosome 15, evaluating 4722250 haplotypes and pair-wise haplotype analysis identified that CHRNA5 rs588765-rs16969968 was the most significant haplotype associated with lung cancer risk (omnibus P = 8.35×10(-15) in discovery and 7.26×10(-14) in replication), and improved the prediction of case status over that provided by the individual SNPs rs16969968 or rs588765 (likelihood ratio test P = 0.006 for rs16969968 and 3.83×10(-14) for rs588765 in discovery, 0.009 for rs16969968 and 4.62×10(-13) for rs588765 in replication, compared with rs588765-rs16969968). Compared with the wild-type homozygous diplotype, CA/CA homozygote exhibited an approximately 2-fold increase risk for lung cancer (OR = 2.12; 95% CI 1.46-3.07 in discovery, and OR = 2.01; 95% CI 1.51-2.67 in replication). Even among never-smokers, CA/CA homozygote showed an increased risk of lung cancer with borderline significance in discovery (adjusted OR = 1.75, 95% CI 0.96-3.19) and statistical significance in replication (adjusted OR = 2.10, 95% CI 1.12-3.96), compared with combined genotypes (CG/CG + CG/TG). Accordingly, rs588765-rs16969968 may be a genetic marker to lung cancer risk, even among never-smokers. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Carcinogenesis AU - Ji, Xuemei AU - Gui, Jiang AU - Han, Younghun AU - Brennan, Paul AU - Li, Yafang AU - McKay, James AU - Caporaso, Neil E AU - Bertazzi, Pier Alberto AU - Landi, Maria Teresa AU - Amos, Christopher I AD - International Agency for Research on Cancer, 69372 Lyon, France. ; Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. ; Department of Clinical Sciences and Community Health, Department of Preventive Medicine, University of Milan, Fondazione IRCCS Ca' Granda Policlinico Hospital, 20122 Milan, Italy. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1275 EP - 1283 VL - 36 IS - 11 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Haplotypes KW - Genetic Loci KW - Humans KW - Genetic Association Studies KW - Case-Control Studies KW - Smoking -- adverse effects KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Carcinoma, Squamous Cell -- genetics KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Chromosomes, Human, Pair 15 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728674496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+role+of+haplotype+in+15q25.1+locus+in+lung+cancer+risk%3A+results+of+scanning+chromosome+15.&rft.au=Ji%2C+Xuemei%3BGui%2C+Jiang%3BHan%2C+Younghun%3BBrennan%2C+Paul%3BLi%2C+Yafang%3BMcKay%2C+James%3BCaporaso%2C+Neil+E%3BBertazzi%2C+Pier+Alberto%3BLandi%2C+Maria+Teresa%3BAmos%2C+Christopher+I&rft.aulast=Ji&rft.aufirst=Xuemei&rft.date=2015-11-01&rft.volume=36&rft.issue=11&rft.spage=1275&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgv118 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-03 N1 - Date created - 2015-10-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Mol Sci. 2014;15(4):5446-57 [24686516] Int J Cancer. 2013 Apr 15;132(8):1811-20 [23011884] Int J Cancer. 1994 Nov 15;59(4):494-504 [7960219] Nature. 2008 Apr 3;452(7187):638-42 [18385739] Nat Genet. 2008 May;40(5):616-22 [18385676] BMC Public Health. 2008;8:203 [18538025] Am J Psychiatry. 2008 Sep;165(9):1163-71 [18519524] Cancer Res. 2008 Nov 15;68(22):9137-40 [19010884] Clin Cancer Res. 2009 Mar 1;15(5):1837-42 [19223495] Hum Mol Genet. 2009 Aug 15;18(16):3125-35 [19443489] Cancer Res. 2009 Aug 15;69(16):6633-41 [19654303] Cancer Res. 2009 Oct 1;69(19):7844-50 [19789337] Nat Genet. 2010 May;42(5):436-40 [20418889] Nat Genet. 2010 May;42(5):441-7 [20418890] J Surg Res. 2010 Jul;162(1):75-8 [19577767] PLoS Genet. 2010 Aug;6(8). pii: e1001053. doi: 10.1371/journal.pgen.1001053 [20700436] J Natl Cancer Inst. 2010 Sep 8;102(17):1366-70 [20733116] PLoS One. 2011;6(4):e19085 [21559498] CA Cancer J Clin. 2011 Jul-Aug;61(4):212-36 [21685461] J Natl Cancer Inst. 2011 Sep 7;103(17):1342-6 [21747048] Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2603-9 [22028403] J Biol Chem. 2012 Mar 2;287(10):7246-55 [22241472] Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):1213-21 [22573796] Nat Genet. 2012 Aug;44(8):895-9 [22797725] Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):251-60 [23221128] Nat Genet. 2014 Jul;46(7):736-41 [24880342] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/carcin/bgv118 ER - TY - JOUR T1 - Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. AN - 1728674481; 26363033 AB - Large-scale genome-wide association studies (GWAS) have likely uncovered all common variants at the GWAS significance level. Additional variants within the suggestive range (0.0001> P > 5×10(-8)) are, however, still of interest for identifying causal associations. This analysis aimed to apply novel variant prioritization approaches to identify additional lung cancer variants that may not reach the GWAS level. Effects were combined across studies with a total of 33456 controls and 6756 adenocarcinoma (AC; 13 studies), 5061 squamous cell carcinoma (SCC; 12 studies) and 2216 small cell lung cancer cases (9 studies). Based on prior information such as variant physical properties and functional significance, we applied stratified false discovery rates, hierarchical modeling and Bayesian false discovery probabilities for variant prioritization. We conducted a fine mapping analysis as validation of our methods by examining top-ranking novel variants in six independent populations with a total of 3128 cases and 2966 controls. Three novel loci in the suggestive range were identified based on our Bayesian framework analyses: KCNIP4 at 4p15.2 (rs6448050, P = 4.6×10(-7)) and MTMR2 at 11q21 (rs10501831, P = 3.1×10(-6)) with SCC, as well as GAREM at 18q12.1 (rs11662168, P = 3.4×10(-7)) with AC. Use of our prioritization methods validated two of the top three loci associated with SCC (P = 1.05×10(-4) for KCNIP4, represented by rs9799795) and AC (P = 2.16×10(-4) for GAREM, represented by rs3786309) in the independent fine mapping populations. This study highlights the utility of using prior functional data for sequence variants in prioritization analyses to search for robust signals in the suggestive range. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Carcinogenesis AU - Brenner, Darren R AU - Amos, Christopher I AU - Brhane, Yonathan AU - Timofeeva, Maria N AU - Caporaso, Neil AU - Wang, Yufei AU - Christiani, David C AU - Bickeböller, Heike AU - Yang, Ping AU - Albanes, Demetrius AU - Stevens, Victoria L AU - Gapstur, Susan AU - McKay, James AU - Boffetta, Paolo AU - Zaridze, David AU - Szeszenia-Dabrowska, Neonilia AU - Lissowska, Jolanta AU - Rudnai, Peter AU - Fabianova, Eleonora AU - Mates, Dana AU - Bencko, Vladimir AU - Foretova, Lenka AU - Janout, Vladimir AU - Krokan, Hans E AU - Skorpen, Frank AU - Gabrielsen, Maiken E AU - Vatten, Lars AU - Njølstad, Inger AU - Chen, Chu AU - Goodman, Gary AU - Lathrop, Mark AU - Vooder, Tõnu AU - Välk, Kristjan AU - Nelis, Mari AU - Metspalu, Andres AU - Broderick, Peter AU - Eisen, Timothy AU - Wu, Xifeng AU - Zhang, Di AU - Chen, Wei AU - Spitz, Margaret R AU - Wei, Yongyue AU - Su, Li AU - Xie, Dong AU - She, Jun AU - Matsuo, Keitaro AU - Matsuda, Fumihiko AU - Ito, Hidemi AU - Risch, Angela AU - Heinrich, Joachim AU - Rosenberger, Albert AU - Muley, Thomas AU - Dienemann, Hendrik AU - Field, John K AU - Raji, Olaide AU - Chen, Ying AU - Gosney, John AU - Liloglou, Triantafillos AU - Davies, Michael P A AU - Marcus, Michael AU - McLaughlin, John AU - Orlow, Irene AU - Han, Younghun AU - Li, Yafang AU - Zong, Xuchen AU - Johansson, Mattias AU - EPIC Investigators AU - Liu, Geoffrey AU - Tworoger, Shelley S AU - Le Marchand, Loic AU - Henderson, Brian E AU - Wilkens, Lynne R AU - Dai, Juncheng AU - Shen, Hongbing AU - Houlston, Richard S AU - Landi, Maria T AU - Brennan, Paul AU - Hung, Rayjean J AD - Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada, Section of Genetics, International Agency for Research on Cancer, 69372 Lyon, France, Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, Alberta T2T 5C7, Canada. ; Department of Community and Family Medicine, Center for Genomic Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03766, USA. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada. ; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, UK. ; Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. ; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK. ; Departments of Environmental Health and Epidemiology, Harvard University School of Public Health, Boston, MA 02115, USA. ; Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, 37073 Göttingen, Germany. ; Division of Health Sciences, Cancer Center and College of Medicine, Mayo Clinic, Rochester, NY 55905, USA. ; Epidemiology Research Program, American Cancer Society, Epidemiology and Surveillance Research, Atlanta, GA 30301, USA. ; Section of Genetics, International Agency for Research on Cancer, 69372 Lyon, France. ; Population Sciences, Tisch Cancer Center and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ; Institute of Carcinogenesis, Russian N.N.Blokhin Cancer Research Centre, 115478 Moscow, Russia. ; Department of Epidemiology, Institute of Occupational Medicine, 91348 Lodz, Poland. ; Department of Epidemiology and Cancer Prevention, The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02781, Poland. ; National Institute of Environmental Health, Budapest 1097, Hungary. ; Department of Health Risk Assessment, Regional Authority of Public Health, Banská Bystrica 97556, Slovak Republic. ; National Institute of Public Health, Bucharest 050463, Romania. ; Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University in Prague, 128 00 Prague 2, Czech Republic. ; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno 65653, Czech Republic. ; Department of Preventive Medicine, Palacky University, Olomouc 77515, Czech Republic. ; Department of Cancer Research and Molecular Medicine, Faculty of Medicine. ; Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine and. ; Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim 7489, Norway. ; Department of Community Medicine, University of Tromso, Tromso N-9037, Norway. ; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. ; McGill University and Genome Québec Innovation Centre, Montréal, Quebec, Canada. ; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia. ; Department of Biomedicine, University of Bergen, Bergen 5009, Norway. ; Institute of Molecular and Cell Biology, Estonian Biocentre, Genotyping Core Facility, Tartu 51010, Estonia. ; Department of Oncology, Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK. ; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ; Department of Genetics, U.T. M.D. Anderson Cancer Center, Houston, TX 77030, USA. ; Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. ; Department of Preventive Medicine, Kyushu University Graduate School of Medicine, Fukuoka City 819-0395, Japan. ; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. ; Department of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku Nagoya 464-0021, Japan. ; Division of Epigenomics and Cancer Risk Factors, DKFZ, 69121 Heidelberg, Germany, Division of Epigenomics and Cancer Risk Factors, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), 69121 Heidelberg, Germany. ; Unit of Environmental Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany. ; Division of Epigenomics and Cancer Risk Factors, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), 69121 Heidelberg, Germany, Translational Research Unit and. ; Division of Epigenomics and Cancer Risk Factors, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), 69121 Heidelberg, Germany, Department of Thoracic Surgery, Thoraxklinik am Universitätsklinikum Heidelberg, 69117 Heidelberg, Germany. ; Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool, Liverpool L69 3BX, UK. ; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ; EPIC Investigators ; Medical Oncology and Haematology, Department of Medicine, Princess Margaret Hospital, Toronto, Ontario M5G 2M9, Canada. ; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. ; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA. ; Keck School of Medicine, University of South California, Los Angeles, CA 90089-0911, USA and. ; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada, rayjean.hung@lunenfeld.ca. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1314 EP - 1326 VL - 36 IS - 11 KW - Index Medicus KW - Humans KW - Case-Control Studies KW - Bayes Theorem KW - Genetic Predisposition to Disease KW - Genome-Wide Association Study KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- genetics KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Lung Neoplasms -- pathology KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728674481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Identification+of+lung+cancer+histology-specific+variants+applying+Bayesian+framework+variant+prioritization+approaches+within+the+TRICL+and+ILCCO+consortia.&rft.au=Brenner%2C+Darren+R%3BAmos%2C+Christopher+I%3BBrhane%2C+Yonathan%3BTimofeeva%2C+Maria+N%3BCaporaso%2C+Neil%3BWang%2C+Yufei%3BChristiani%2C+David+C%3BBickeb%C3%B6ller%2C+Heike%3BYang%2C+Ping%3BAlbanes%2C+Demetrius%3BStevens%2C+Victoria+L%3BGapstur%2C+Susan%3BMcKay%2C+James%3BBoffetta%2C+Paolo%3BZaridze%2C+David%3BSzeszenia-Dabrowska%2C+Neonilia%3BLissowska%2C+Jolanta%3BRudnai%2C+Peter%3BFabianova%2C+Eleonora%3BMates%2C+Dana%3BBencko%2C+Vladimir%3BForetova%2C+Lenka%3BJanout%2C+Vladimir%3BKrokan%2C+Hans+E%3BSkorpen%2C+Frank%3BGabrielsen%2C+Maiken+E%3BVatten%2C+Lars%3BNj%C3%B8lstad%2C+Inger%3BChen%2C+Chu%3BGoodman%2C+Gary%3BLathrop%2C+Mark%3BVooder%2C+T%C3%B5nu%3BV%C3%A4lk%2C+Kristjan%3BNelis%2C+Mari%3BMetspalu%2C+Andres%3BBroderick%2C+Peter%3BEisen%2C+Timothy%3BWu%2C+Xifeng%3BZhang%2C+Di%3BChen%2C+Wei%3BSpitz%2C+Margaret+R%3BWei%2C+Yongyue%3BSu%2C+Li%3BXie%2C+Dong%3BShe%2C+Jun%3BMatsuo%2C+Keitaro%3BMatsuda%2C+Fumihiko%3BIto%2C+Hidemi%3BRisch%2C+Angela%3BHeinrich%2C+Joachim%3BRosenberger%2C+Albert%3BMuley%2C+Thomas%3BDienemann%2C+Hendrik%3BField%2C+John+K%3BRaji%2C+Olaide%3BChen%2C+Ying%3BGosney%2C+John%3BLiloglou%2C+Triantafillos%3BDavies%2C+Michael+P+A%3BMarcus%2C+Michael%3BMcLaughlin%2C+John%3BOrlow%2C+Irene%3BHan%2C+Younghun%3BLi%2C+Yafang%3BZong%2C+Xuchen%3BJohansson%2C+Mattias%3BEPIC+Investigators%3BLiu%2C+Geoffrey%3BTworoger%2C+Shelley+S%3BLe+Marchand%2C+Loic%3BHenderson%2C+Brian+E%3BWilkens%2C+Lynne+R%3BDai%2C+Juncheng%3BShen%2C+Hongbing%3BHoulston%2C+Richard+S%3BLandi%2C+Maria+T%3BBrennan%2C+Paul%3BHung%2C+Rayjean+J&rft.aulast=Brenner&rft.aufirst=Darren&rft.date=2015-11-01&rft.volume=36&rft.issue=11&rft.spage=1314&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgv128 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-03 N1 - Date created - 2015-10-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Carcinogenesis. 2006 May;27(5):1024-9 [16311244] Genet Epidemiol. 2006 Sep;30(6):519-30 [16800000] Am J Epidemiol. 2006 Dec 15;164(12):1233-41 [17032696] Am J Hum Genet. 2007 Apr;80(4):605-15 [17357068] Am J Hum Genet. 2007 Aug;81(2):208-27 [17668372] Am J Hum Genet. 2007 Aug;81(2):397-404 [17668389] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] Nat Rev Cancer. 2007 Oct;7(10):778-90 [17882278] Cancer Genet Cytogenet. 2007 Nov;179(1):11-8 [17981209] Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2736-44 [18086781] Nature. 2008 Apr 3;452(7187):633-7 [18385738] Nature. 2008 Apr 3;452(7187):638-42 [18385739] Nat Genet. 2008 May;40(5):616-22 [18385676] Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1127-35 [18483334] Int J Epidemiol. 2008 Jun;37(3):641-53 [18270206] BMC Public Health. 2008;8:203 [18538025] Genome Res. 2012 Sep;22(9):1790-7 [22955989] Science. 2012 Sep 7;337(6099):1190-5 [22955828] Cell. 2012 Sep 14;150(6):1107-20 [22980975] Cell. 2012 Sep 14;150(6):1121-34 [22980976] Nat Genet. 2012 Oct;44(10):1074-5 [23011222] Nature. 2012 Sep 27;489(7417):519-25 [22960745] Hum Mol Genet. 2012 Nov 15;21(22):4980-95 [22899653] PLoS One. 2013;8(2):e56179 [23457522] Hum Genet. 2013 May;132(5):579-89 [23370545] Nat Genet. 2013 Jun;45(6):580-5 [23715323] Nat Genet. 2008 Dec;40(12):1404-6 [18978790] Nat Genet. 2014 Jul;46(7):736-41 [24880342] Genet Epidemiol. 2015 May;39(4):306-16 [25847094] J Clin Oncol. 2008 Jul 20;26(21):3560-6 [18640936] Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3081-9 [18990748] Nat Genet. 2008 Dec;40(12):1407-9 [18978787] Bioinformatics. 2008 Dec 15;24(24):2938-9 [18974171] Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7 [19474294] Genet Epidemiol. 2009 Jan;33(1):79-86 [18642345] J Biol Chem. 2009 Jul 24;284(30):20206-14 [19509291] Am J Hum Genet. 2009 Nov;85(5):679-91 [19836008] Carcinogenesis. 2010 Apr;31(4):625-33 [20106900] Lancet Oncol. 2010 Apr;11(4):321-30 [20304703] BMC Bioinformatics. 2010;11:288 [20509871] BMC Cancer. 2010;10:285 [20546590] Bioinformatics. 2010 Sep 15;26(18):2336-7 [20634204] Cancer Res. 2011 Feb 15;71(4):1356-61 [21303977] CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 [21296855] Lancet Oncol. 2011 Apr;12(4):399-408 [20951091] PLoS One. 2011;6(4):e14808 [21556132] Nat Genet. 2011 Aug;43(8):792-6 [21725308] Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 [22064851] Carcinogenesis. 2012 Mar;33(3):587-97 [22198214] Cancer Discov. 2012 Feb;2(2):131-9 [22585858] PLoS One. 2012;7(5):e36888 [22662130] Nat Genet. 2012 May;44(5):562-9 [22466613] J Thorac Oncol. 2012 May;7(5):790-8 [22430809] Genome Res. 2012 Sep;22(9):1748-59 [22955986] Cancer. 2002 May 1;94(9):2490-501 [12015775] Nucleic Acids Res. 2003 Jul 1;31(13):3812-4 [12824425] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 [12883005] BMJ. 2003 Sep 6;327(7414):557-60 [12958120] Eur J Hum Genet. 2004 May;12(5):395-9 [14872201] Stat Med. 1993 Apr 30;12(8):717-36 [8516590] Ann Epidemiol. 1994 Jan;4(1):1-10 [8205268] Genome Res. 2005 Aug;15(8):1034-50 [16024819] Genomics. 2005 Nov;86(5):581-93 [16112838] Int J Oncol. 2005 Dec;27(6):1633-45 [16273220] Mutat Res. 2005 Dec 30;592(1-2):147-54 [16054167] Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):639-44 [16614103] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/carcin/bgv128 ER - TY - JOUR T1 - Undocumented status as a social determinant of occupational safety and health: The workers' perspective AN - 1727697654; PQ0002166927 AB - Background Undocumented immigration to the United States has grown dramatically over the past 25 years. This study explores undocumented status as a social determinant of occupational health by examining its perceived consequences on workplace safety of Latino immigrants. Methods Guided by the Theory of Work Adjustment, qualitative analysis was conducted on transcripts from focus groups and individual interviews conducted with a convenience sample of Latino immigrant workers. Results Participants reported that unauthorized status negatively impacted their safety at work and resulted in a degree of alienation that exceeded the specific proscriptions of the law. Participants overwhelming used a strategy of disengagement to cope with the challenges they face as undocumented immigrants. Conclusion This study describes the complex web of consequences resulting from undocumented status and its impact on occupational health. This study presents a framework connecting the daily work experiences of immigrants, the coping strategy of disengagement, and efforts to minimize the impact of structural violence. Am. J. Ind. Med. 58:1127-1137, 2015. JF - American Journal of Industrial Medicine AU - Flynn, Michael A AU - Eggerth, Donald E AU - Jacobson, CJeffrey AD - National Institute for Occupational Safety and Health, Education and Information Division, Cincinnati, Ohio. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1127 EP - 1137 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 11 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Qualitative analysis KW - Immigration KW - Safety KW - Occupational safety KW - Immigrants KW - Violence KW - Workers KW - USA KW - Perception KW - Aggression KW - Ethnic groups KW - Occupational health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727697654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Undocumented+status+as+a+social+determinant+of+occupational+safety+and+health%3A+The+workers%27+perspective&rft.au=Flynn%2C+Michael+A%3BEggerth%2C+Donald+E%3BJacobson%2C+CJeffrey&rft.aulast=Flynn&rft.aufirst=Michael&rft.date=2015-11-01&rft.volume=58&rft.issue=11&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22531 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Workers; Immigration; Immigrants; Aggression; Qualitative analysis; Perception; Occupational safety; Safety; Violence; Ethnic groups; Occupational health; USA DO - http://dx.doi.org/10.1002/ajim.22531 ER - TY - JOUR T1 - Trends of occupational fatalities involving machines, United States, 1992-2010 AN - 1727686389; PQ0002166928 AB - Background This paper describes trends of occupational machine-related fatalities from 1992-2010. We examine temporal patterns by worker demographics, machine types (e.g., stationary, mobile), and industries. Methods We analyzed fatalities from Census of Fatal Occupational Injuries data provided by the Bureau of Labor Statistics to the National Institute for Occupational Safety and Health. We used injury source to identify machine-related incidents and Poisson regression to assess trends over the 19-year period. Results There was an average annual decrease of 2.8% in overall machine-related fatality rates from 1992 through 2010. Mobile machine-related fatality rates decreased an average of 2.6% annually and stationary machine-related rates decreased an average of 3.5% annually. Groups that continued to be at high risk included older workers; self-employed; and workers in agriculture/forestry/fishing, construction, and mining. Conclusion Addressing dangers posed by tractors, excavators, and other mobile machines needs to continue. High-risk worker groups should receive targeted information on machine safety. Am. J. Ind. Med. 58:1160-1173, 2015. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Marsh, Suzanne M AU - Fosbroke, David E AD - National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, Morgantown, West Virginia. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1160 EP - 1173 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 11 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Agriculture KW - Mortality KW - Statistics KW - Data processing KW - Injuries KW - Occupational safety KW - Safety KW - Demography KW - Fishing KW - Workers KW - USA KW - Risk factors KW - Risk groups KW - Census KW - Agricultural equipment KW - Forestry KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727686389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Trends+of+occupational+fatalities+involving+machines%2C+United+States%2C+1992-2010&rft.au=Marsh%2C+Suzanne+M%3BFosbroke%2C+David+E&rft.aulast=Marsh&rft.aufirst=Suzanne&rft.date=2015-11-01&rft.volume=58&rft.issue=11&rft.spage=1160&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22532 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Agriculture; Demography; Workers; Data processing; Statistics; Injuries; Risk factors; Risk groups; Census; Forestry; Risk assessment; Fishing; Mortality; Safety; Occupational safety; Agricultural equipment; USA DO - http://dx.doi.org/10.1002/ajim.22532 ER - TY - JOUR T1 - Instrumental improvements and sample preparations that enable reproducible, reliable acquisition of mass spectra from whole bacterial cells AN - 1727684952; PQ0002116636 AB - Rationale Rapid sub-species characterization of pathogens is required for timely responses in outbreak situations. Pyrolysis mass spectrometry (PyMS) has the potential to be used for this purpose. Methods However, in order to make PyMS practical for traceback applications, certain improvements related to spectrum reproducibility and data acquisition speed were required. The main objectives of this study were to facilitate fast detection (<30 min to analyze 6 samples, including preparation) and sub-species-level bacterial characterization based on pattern recognition of mass spectral fingerprints acquired from whole cells volatilized and ionized at atmospheric pressure. An AccuTOF DART mass spectrometer was re-engineered to permit ionization of low-volatility bacteria by means of Plasma Jet Ionization (PJI), in which an electric discharge, and, by extension, a plasma beam, impinges on sample cells. Results Instrumental improvements and spectral acquisition methodology are described. Performance of the re-engineered system was assessed using a small challenge set comprised of assorted bacterial isolates differing in identity by varying amounts. In general, the spectral patterns obtained allowed differentiation of all samples tested, including those of the same genus and species but different serotypes. Conclusions Fluctuations of plus or minus 15% in bacterial cell concentrations did not substantially compromise replicate spectra reproducibility. JF - Rapid Communications in Mass Spectrometry AU - Alusta, Pierre AU - Buzatu, Dan AU - Williams, Anna AU - Cooper, Willie-Mae AU - Tarasenko, Olga AU - Dorey, RCameron AU - Hall, Reggie AU - Parker, WRyan AU - Wilkes, Jon G AD - Innovative Safety Technologies Branch, Systems Biology Div, National Center for Toxicological Research, Food Drug Administration, Jefferson, AR, USA. Y1 - 2015/11// PY - 2015 DA - Nov 2015 SP - 1961 EP - 1968 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 29 IS - 21 SN - 0951-4198, 0951-4198 KW - Microbiology Abstracts B: Bacteriology KW - Pyrolysis KW - Bacteria KW - Pattern recognition KW - Differentiation KW - Serotypes KW - Atmospheric pressure KW - Pathogens KW - Ionization KW - Mass spectroscopy KW - Data acquisition KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727684952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+Communications+in+Mass+Spectrometry&rft.atitle=Instrumental+improvements+and+sample+preparations+that+enable+reproducible%2C+reliable+acquisition+of+mass+spectra+from+whole+bacterial+cells&rft.au=Alusta%2C+Pierre%3BBuzatu%2C+Dan%3BWilliams%2C+Anna%3BCooper%2C+Willie-Mae%3BTarasenko%2C+Olga%3BDorey%2C+RCameron%3BHall%2C+Reggie%3BParker%2C+WRyan%3BWilkes%2C+Jon+G&rft.aulast=Alusta&rft.aufirst=Pierre&rft.date=2015-11-01&rft.volume=29&rft.issue=21&rft.spage=1961&rft.isbn=&rft.btitle=&rft.title=Rapid+Communications+in+Mass+Spectrometry&rft.issn=09514198&rft_id=info:doi/10.1002%2Frcm.7299 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Pyrolysis; Differentiation; Pattern recognition; Serotypes; Atmospheric pressure; Pathogens; Ionization; Data acquisition; Mass spectroscopy; Bacteria DO - http://dx.doi.org/10.1002/rcm.7299 ER - TY - JOUR T1 - Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid. AN - 1722930958; 25154389 AB - The level of 5-hydroxymethylcytosine (5-hmC) converted by ten-eleven translocation (TET) family is decreased in cancers. However, whether 5-hmC level is perturbed in early stages of carcinogenesis caused by genotoxic carcinogens is not defined. 5-hmC levels and TET2 expression were measured in liver of rats treated with genotoxic carcinogens, riddelliine, or aristolochic acid. Levels of 5-hmC and TET2 expression decreased in the liver of the carcinogens-treated rats. Loss of 5-hmC correlates well with documented induction of genetic mutations by the carcinogens, suggesting that TET2-mediated 5-hydroxymethylation plays an epigenetic role in early state of carcinogenesis. © 2014 Wiley Periodicals, Inc. JF - Molecular carcinogenesis AU - Lian, Christine Guo AU - Xu, Shuyun AU - Guo, Weimin AU - Yan, Jian AU - Frank, Maximilian Y M AU - Liu, Robert AU - Liu, Cynthia AU - Chen, Ying AU - Murphy, George F AU - Chen, Tao AD - Program in Dermatopathology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1503 EP - 1507 VL - 54 IS - 11 KW - Aristolochic Acids KW - 0 KW - Carcinogens KW - DNA-Binding Proteins KW - Pyrrolizidine Alkaloids KW - 5-hydroxymethylcytosine KW - 1123-95-1 KW - riddelliine KW - 23246-96-0 KW - Cytosine KW - 8J337D1HZY KW - aristolochic acid I KW - 94218WFP5T KW - Index Medicus KW - ten-eleven translocation KW - carcinogenesis KW - mutagenesis KW - aristolochic acid KW - Rats KW - Mutation -- drug effects KW - Animals KW - Rats, Inbred F344 KW - Rats, Transgenic KW - Neoplasms -- chemically induced KW - Epigenesis, Genetic -- drug effects KW - Carcinogenesis -- drug effects KW - Neoplasms -- metabolism KW - DNA-Binding Proteins -- metabolism KW - Aristolochic Acids -- toxicity KW - Carcinogens -- toxicity KW - Liver -- metabolism KW - Pyrrolizidine Alkaloids -- toxicity KW - Cytosine -- analogs & derivatives KW - Cytosine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722930958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Decrease+of+5-hydroxymethylcytosine+in+rat+liver+with+subchronic+exposure+to+genotoxic+carcinogens+riddelliine+and+aristolochic+acid.&rft.au=Lian%2C+Christine+Guo%3BXu%2C+Shuyun%3BGuo%2C+Weimin%3BYan%2C+Jian%3BFrank%2C+Maximilian+Y+M%3BLiu%2C+Robert%3BLiu%2C+Cynthia%3BChen%2C+Ying%3BMurphy%2C+George+F%3BChen%2C+Tao&rft.aulast=Lian&rft.aufirst=Christine&rft.date=2015-11-01&rft.volume=54&rft.issue=11&rft.spage=1503&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.22201 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-01 N1 - Date created - 2015-10-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/mc.22201 ER - TY - JOUR T1 - Experiences and Lessons From Implementing Cohort Event Monitoring Programmes for Antimalarials in Four African Countries: Results of a Questionnaire-Based Survey. AN - 1722926989; 26267842 AB - Cohort event monitoring (CEM) is an intensive method of post-marketing surveillance for medicines safety. The method is based on prescription event monitoring, which began in the 1970s, and has since been adapted by WHO for monitoring the safety of medicines used in Public Health Programmes. CEM aims to capture all adverse events that occur in a defined group of patients after starting treatment with a specific medicine during the course of routine clinical practice. The aims of this study were to describe the experiences of National Pharmacovigilance Centres (NCs) that have used CEM to monitor artemisinin-based combination therapy (ACT) for uncomplicated malaria in the African setting, to raise awareness of some of the challenges encountered during implementation and to highlight aspects of the method that require further consideration. A questionnaire-based survey was conducted to capture the experiences of NCs that have implemented CEM for active post-marketing surveillance of antimalarial medicines in sub-Saharan Africa. Six NCs were identified as having implemented CEM programmes and were invited to participate in the survey; five NCs indicated willingness to participate and were sent the questionnaire to complete. Four NCs responded to the survey-Ghana, Kenya, Nigeria and Zimbabwe-providing information on the implementation of a total of six CEM programmes. Their experiences indicate that CEM has helped to build pharmacovigilance capacity within the participating NCs and at the monitoring sites, and that healthcare providers (HCPs) are generally willing to participate in implementing the CEM method. All of the programmes took longer than expected to complete: contributing factors included a prolonged enrolment period and unexpectedly slow data entry. All of the programmes exceeded their budget by 11.1-63.2 %. Data management was identified as a challenge for all participating NCs. The reported experiences of four NCs that have undertaken CEM studies on ACTs indicate that CEM has helped to build pharmacovigilance capacity within NCs and monitoring sites and that HCPs are willing to participate in CEM programmes; however, the method was found to be labour intensive and data management was identified as a challenge. Reducing the workload associated with CEM, particularly in relation to data management, and integrating the method into the routine work of HCPs and NCs should be considered for future implementation. JF - Drug safety AU - Suku, Comfort Kunak AU - Hill, Geraldine AU - Sabblah, George AU - Darko, Mimi AU - Muthuri, George AU - Abwao, Edward AU - Pandit, Jayesh AU - Osakwe, Adeline Ijeoma AU - Elagbaje, Cassandra AU - Nyambayo, Priscilla AU - Khoza, Star AU - Dodoo, Alexander N AU - Pal, Shanthi Narayan AD - National Pharmacovigilance Centre, National Agency for Food and Drug Administration and Control (NAFDAC), Abuja, FCT, Nigeria. kunacom@yahoo.com. ; Uppsala Monitoring Centre (UMC), Uppsala, Sweden. ; National Pharmacovigilance Centre, Food and Drug Authority (FDA), Accra, Ghana. ; National Pharmacovigilance Centre, Pharmacy and Poison Board (PPB), Nairobi, Kenya. ; National Pharmacovigilance Centre, National Agency for Food and Drug Administration and Control (NAFDAC), Abuja, FCT, Nigeria. ; National Pharmacovigilance Centre, Medicine Control Authority of Zimbabwe (MCAZ), Harare, Zimbabwe. ; WHO Collaborating Centre (WHO CC) for Advocacy and Training in Pharmacovigilance, School of Medicine and Dentistry, University of Ghana, Accra, Ghana. ; Safety and Vigilance (SAV), WHO, Geneva, Switzerland. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1115 EP - 1126 VL - 38 IS - 11 KW - Antimalarials KW - 0 KW - Index Medicus KW - Zimbabwe -- epidemiology KW - Prospective Studies KW - Humans KW - Ghana -- epidemiology KW - Cohort Studies KW - Nigeria -- epidemiology KW - Kenya -- epidemiology KW - Pharmacovigilance KW - Antimalarials -- adverse effects KW - Surveys and Questionnaires UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722926989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Experiences+and+Lessons+From+Implementing+Cohort+Event+Monitoring+Programmes+for+Antimalarials+in+Four+African+Countries%3A+Results+of+a+Questionnaire-Based+Survey.&rft.au=Suku%2C+Comfort+Kunak%3BHill%2C+Geraldine%3BSabblah%2C+George%3BDarko%2C+Mimi%3BMuthuri%2C+George%3BAbwao%2C+Edward%3BPandit%2C+Jayesh%3BOsakwe%2C+Adeline+Ijeoma%3BElagbaje%2C+Cassandra%3BNyambayo%2C+Priscilla%3BKhoza%2C+Star%3BDodoo%2C+Alexander+N%3BPal%2C+Shanthi+Narayan&rft.aulast=Suku&rft.aufirst=Comfort&rft.date=2015-11-01&rft.volume=38&rft.issue=11&rft.spage=1115&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=1179-1942&rft_id=info:doi/10.1007%2Fs40264-015-0331-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-28 N1 - Date created - 2015-10-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Med Trop (Mars). 1998;58(3 Suppl):93-6 [10212911] Malar J. 2006;5:50 [16780575] Malar J. 2012;11:402 [23216982] Drug Saf. 2013 Feb;36(2):75-81 [23329541] Drug Saf. 2014 Jun;37(6):433-48 [24788801] Drug Saf. 2015 Jan;38(1):87-100 [25539877] Malar J. 2015;14:160 [25885858] Drug Saf. 2015 Apr;38(4):365-72 [25808626] Drug Saf. 2015 Apr;38(4):319-28 [25829215] Drug Saf. 2013 Sep;36(9):747-56 [23591829] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s40264-015-0331-7 ER - TY - JOUR T1 - The Reinforcing Effects of Nicotine in Humans and Nonhuman Primates: A Review of Intravenous Self-Administration Evidence and Future Directions for Research. AN - 1722185967; 25673111 AB - Cigarette smoking is largely driven by the reinforcing properties of nicotine. Intravenous (IV) self-administration procedures are the gold standard for investigating the reinforcing effects of psychoactive drugs. The goal of this review was to examine the results of published investigations of the reinforcing effects of nicotine measured using IV self-administration procedures in humans and nonhuman primates. The body of literature using nonhuman primate subjects indicates nicotine functions as a positive reinforcer when available for self-administration via IV catheters. However, it can also be difficult to establish IV nicotine self-administration in nonhuman primates and sometimes supplemental strategies have been required (e.g., priming injections or food deprivation) before subjects acquire the behavior. Although the body of literature using human subjects is limited, the evidence indicates nicotine functions as a reinforcer via the IV route of administration in adult cigarette smokers. Rates of nicotine self-injection can be variable across subjects and responding is sometimes inconsistent across sessions in both humans and nonhuman primates. The Family Smoking Prevention and Tobacco Control Act, enacted in 2009, gave the Food and Drug Administration regulatory authority over the manufacture, marketing, and distribution of tobacco products. Research examining the threshold reinforcing doses for initiation and maintenance of nicotine self-administration, comparisons of the reinforcing effects of nicotine in adolescent versus adult subjects, investigations of gender differences in the reinforcing effects of nicotine, and studies of the abuse liability of non-nicotine tobacco product constituents and their ability to alter the reinforcing effects of nicotine will inform potential tobacco regulatory actions. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Goodwin, Amy K AU - Hiranita, Takato AU - Paule, Merle G AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR Amy.Goodwin@fda.hhs.gov. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1297 EP - 1310 VL - 17 IS - 11 KW - Ganglionic Stimulants KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Animals KW - Humans KW - Primates KW - Smoking KW - Behavior -- drug effects KW - Injections, Intravenous KW - Reinforcement (Psychology) KW - Nicotine -- administration & dosage KW - Ganglionic Stimulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722185967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=The+Reinforcing+Effects+of+Nicotine+in+Humans+and+Nonhuman+Primates%3A+A+Review+of+Intravenous+Self-Administration+Evidence+and+Future+Directions+for+Research.&rft.au=Goodwin%2C+Amy+K%3BHiranita%2C+Takato%3BPaule%2C+Merle+G&rft.aulast=Goodwin&rft.aufirst=Amy&rft.date=2015-11-01&rft.volume=17&rft.issue=11&rft.spage=1297&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=1469-994X&rft_id=info:doi/10.1093%2Fntr%2Fntv002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-30 N1 - Date created - 2015-10-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/ntr/ntv002 ER - TY - JOUR T1 - MyD88 mediates in vivo effector functions of alveolar macrophages in acute lung inflammatory responses to carbon nanotube exposure. AN - 1722185454; 26272622 AB - Carbon nanotubes (CNTs) are rapidly emerging as high-priority occupational toxicants. CNT powders contain fibrous particles that aerosolize readily in places of manufacture and handling, posing an inhalation risk for workers. Studies using animal models indicate that lung exposure to CNTs causes prolonged inflammatory responses and diffuse alveolar injury. The mechanisms governing CNT-induced lung inflammation are not fully understood but have been suggested to involve alveolar macrophages (AMs). In the current study, we sought to systematically assess the effector role of AMs in vivo in the induction of lung inflammatory responses to CNT exposures and investigate their cell type-specific mechanisms. Multi-wall CNTs characterized for various physicochemical attributes were used as the CNT type. Using an AM-specific depletion and repopulation approach in a mouse model, we unambiguously demonstrated that AMs are major effector cells necessary for the in vivo elaboration of CNT-induced lung inflammation. We further investigated in vitro AM responses and identified molecular targets which proved critical to pro-inflammatory responses in this model, namely MyD88 as well as MAPKs and Ca(2+)/CamKII. We further demonstrated that MyD88 inhibition in donor AMs abrogated their capacity to reconstitute CNT-induced inflammation when adoptively transferred into AM-depleted mice. Taken together, this is the first in vivo demonstration that AMs act as critical effector cell types in CNT-induced lung inflammation and that MyD88 is required for this in vivo effector function. AMs and their cell type-specific mechanisms may therefore represent potential targets for future therapeutic intervention of CNT-related lung injury. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Toxicology and applied pharmacology AU - Frank, Evan A AU - Birch, M Eileen AU - Yadav, Jagjit S AD - Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. ; National Institute for Occupational Safety and Health, Cincinnati, OH 45213, USA. ; Division of Environmental Genetics and Molecular Toxicology, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: Jagjit.Yadav@uc.edu. Y1 - 2015/11/01/ PY - 2015 DA - 2015 Nov 01 SP - 322 EP - 329 VL - 288 IS - 3 KW - Interleukin-1beta KW - 0 KW - Myd88 protein, mouse KW - Myeloid Differentiation Factor 88 KW - Nanotubes, Carbon KW - Tumor Necrosis Factor-alpha KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - p38 Mitogen-Activated Protein Kinases KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Carbon nanotubes KW - Macrophage depletion KW - Particle toxicology KW - Nanotoxicology KW - Molecular toxicology KW - Acute Disease KW - Animals KW - Interleukin-1beta -- genetics KW - Particle Size KW - p38 Mitogen-Activated Protein Kinases -- genetics KW - Lung -- cytology KW - Disease Models, Animal KW - Mice KW - Lung -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Calcium -- metabolism KW - Cells, Cultured KW - Chemical Phenomena KW - Interleukin-1beta -- metabolism KW - Lung -- drug effects KW - JNK Mitogen-Activated Protein Kinases -- genetics KW - Tumor Necrosis Factor-alpha -- metabolism KW - Signal Transduction KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Myeloid Differentiation Factor 88 -- metabolism KW - Macrophages, Alveolar -- metabolism KW - Myeloid Differentiation Factor 88 -- genetics KW - Macrophages, Alveolar -- drug effects KW - Nanotubes, Carbon -- toxicity KW - Pneumonia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722185454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=MyD88+mediates+in+vivo+effector+functions+of+alveolar+macrophages+in+acute+lung+inflammatory+responses+to+carbon+nanotube+exposure.&rft.au=Frank%2C+Evan+A%3BBirch%2C+M+Eileen%3BYadav%2C+Jagjit+S&rft.aulast=Frank&rft.aufirst=Evan&rft.date=2015-11-01&rft.volume=288&rft.issue=3&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-19 N1 - Date created - 2015-10-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Biomaterials. 2009 Sep;30(25):4152-60 [19473699] Nat Cell Biol. 2002 May;4(5):E131-6 [11988758] Toxicology. 2010 Mar 10;269(2-3):136-47 [19857541] J Virol. 2010 Aug;84(15):7569-80 [20504924] Biomaterials. 2011 Aug;32(22):5206-12 [21492934] Part Fibre Toxicol. 2011;8:21 [21781304] Part Fibre Toxicol. 2011;8:24 [21851604] ACS Nano. 2011 Sep 27;5(9):6861-70 [21800904] PLoS One. 2011;6(11):e27137 [22073274] Ann Occup Hyg. 2012 Jul;56(5):542-56 [22156567] Small. 2012 Sep 24;8(18):2904-12 [22777948] Part Fibre Toxicol. 2012;9:14 [22571318] Science. 2013 Feb 1;339(6119):535-9 [23372006] Shock. 2000 May;13(5):346-60 [10807009] Part Fibre Toxicol. 2014;11:28 [24915862] Am J Physiol Lung Cell Mol Physiol. 2004 Feb;286(2):L344-53 [14555462] J Exp Med. 1989 Aug 1;170(2):499-509 [2526847] Am J Respir Cell Mol Biol. 1989 Aug;1(2):145-54 [2620000] Environ Health Perspect. 1992 Jul;97:193-9 [1396458] J Cell Biol. 1993 Dec;123(5):1107-17 [8245121] Thorax. 1996 Dec;51(12):1253-61 [8994525] Infect Immun. 1998 Jul;66(7):3164-9 [9632581] Toxicol Lett. 2006 Aug 1;165(1):88-100 [16527436] Semin Respir Crit Care Med. 2006 Aug;27(4):337-49 [16909368] Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1018-26 [16861385] Am J Physiol Lung Cell Mol Physiol. 2006 Dec;291(6):L1191-8 [16877636] Int Arch Allergy Immunol. 2006;141(4):354-68 [16940747] Toxicol Lett. 2007 Jan 10;168(1):58-74 [17141434] Nat Rev Immunol. 2007 Mar;7(3):179-90 [17318230] Inhal Toxicol. 2008 Jun;20(8):741-9 [18569096] Chem Res Toxicol. 2008 Sep;21(9):1698-705 [18636756] Toxicol Appl Pharmacol. 2008 Oct 15;232(2):244-51 [18655803] Toxicol Sci. 2009 May;109(1):113-23 [19293371] Nanotoxicology. 2013 Mar;7(2):157-68 [22263913] Toxicology. 2013 Jun 7;308:1-9 [23499856] Exp Toxicol Pathol. 2013 Sep;65(6):887-96 [23352990] Nanotoxicology. 2014 Feb;8(1):17-27 [23094697] Toxicol Sci. 2009 Dec;112(2):468-81 [19584127] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.08.004 ER - TY - JOUR T1 - MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells. AN - 1721632942; 26296572 AB - Cytochrome P450 2C19 (CYP2C19) is involved in the metabolism of many drugs. Extensive studies have demonstrated that genetic variants and endogenous and environmental factors play important roles in the expression of CYP2C19. However, the role of microRNAs (miRNAs) in controlling CYP2C19 expression has not been investigated completely. In the present study, we performed in silico analysis to rank putative miRNA/CYP2C19 hybrids with regards to the predicted stabilities of their duplexes and then we applied a series of biochemical and molecular assays to elucidate the underlying functional mechanisms for the regulation of CYP2C19 by miRNAs. In silico analysis indicated that hsa-miR-23a-3p and hsa-miR-29a-3p target the coding region of CYP2C19 with hybrid stabilities of -27.5kcal/mol and -23.3kcal/mol, respectively. RNA electrophoresis mobility shift assays showed that both hsa-miR-23a-3p and hsa-miR-29a-3p miRNAs were able to bind directly to their cognate targets in the CYP2C19 transcript. Further, a significant inverse correlation was found between chemically-induced up-regulation of hsa-miR-29a-3p and CYP2C19 expression in HepaRG cells. In addition, inverse correlations were also observed in human liver tissue samples between the level of CYP2C19 mRNA expression and both hsa-miR-23a-3p and hsa-miR-29a-3p levels. All these results demonstrated the suppressing role of hsa-miR-29a-3p on CYP2C19 expression. Published by Elsevier Inc. JF - Biochemical pharmacology AU - Yu, Dianke AU - Green, Bridgett AU - Tolleson, William H AU - Jin, Yaqiong AU - Mei, Nan AU - Guo, Yongli AU - Deng, Helen AU - Pogribny, Igor AU - Ning, Baitang AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. ; Arkansas Department of Health, Little Rock, AR 72205, USA. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: baitang.ning@fda.hhs.gov. Y1 - 2015/11/01/ PY - 2015 DA - 2015 Nov 01 SP - 215 EP - 223 VL - 98 IS - 1 KW - MIRN29 microRNA, human KW - 0 KW - MicroRNAs KW - CYP2C19 protein, human KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP2C19 KW - Index Medicus KW - Pharmacogenomics KW - CYP2C19 KW - Drug metabolizing enzymes KW - hsa-miR-29a-3p KW - microRNA KW - Inter-individual variability KW - Humans KW - Kidney -- embryology KW - Cell Line KW - MicroRNAs -- metabolism KW - Gene Expression Regulation -- physiology KW - Cytochrome P-450 CYP2C19 -- metabolism KW - MicroRNAs -- genetics KW - Cytochrome P-450 CYP2C19 -- genetics KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1721632942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=MicroRNA+hsa-miR-29a-3p+modulates+CYP2C19+in+human+liver+cells.&rft.au=Yu%2C+Dianke%3BGreen%2C+Bridgett%3BTolleson%2C+William+H%3BJin%2C+Yaqiong%3BMei%2C+Nan%3BGuo%2C+Yongli%3BDeng%2C+Helen%3BPogribny%2C+Igor%3BNing%2C+Baitang&rft.aulast=Yu&rft.aufirst=Dianke&rft.date=2015-11-01&rft.volume=98&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2015.08.094 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-09 N1 - Date created - 2015-10-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcp.2015.08.094 ER - TY - JOUR T1 - Modification of Occupational Exposures on Bladder Cancer Risk by Common Genetic Polymorphisms. AN - 1713526828; 26374428 AB - Few studies have demonstrated gene/environment interactions in cancer research. Using data on high-risk occupations for 2258 case patients and 2410 control patients from two bladder cancer studies, we observed that three of 16 known or candidate bladder cancer susceptibility variants displayed statistically significant and consistent evidence of additive interactions; specifically, the GSTM1 deletion polymorphism (P interaction ≤ .001), rs11892031 (UGT1A, P interaction = .01), and rs798766 (TMEM129-TACC3-FGFR3, P interaction = .03). There was limited evidence for multiplicative interactions. When we examined detailed data on a prevalent occupational exposure associated with increased bladder cancer risk, straight metalworking fluids, we also observed statistically significant additive interaction for rs798766 (TMEM129-TACC3-FGFR3, P interaction = .02), with the interaction more apparent in patients with tumors positive for FGFR3 expression. All statistical tests were two-sided. The interaction we observed for rs798766 (TMEM129-TACC3-FGFR3) with specific exposure to straight metalworking fluids illustrates the value of integrating germline genetic variation, environmental exposures, and tumor marker data to provide insight into the mechanisms of bladder carcinogenesis. Published by Oxford University Press 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US. JF - Journal of the National Cancer Institute AU - Figueroa, Jonine D AU - Koutros, Stella AU - Colt, Joanne S AU - Kogevinas, Manolis AU - Garcia-Closas, Montserrat AU - Real, Francisco X AU - Friesen, Melissa C AU - Baris, Dalsu AU - Stewart, Patricia AU - Schwenn, Molly AU - Johnson, Alison AU - Karagas, Margaret R AU - Armenti, Karla R AU - Moore, Lee E AU - Schned, Alan AU - Lenz, Petra AU - Prokunina-Olsson, Ludmila AU - Banday, A Rouf AU - Paquin, Ashley AU - Ylaya, Kris AU - Chung, Joon-Yong AU - Hewitt, Stephen M AU - Nickerson, Michael L AU - Tardón, Adonina AU - Serra, Consol AU - Carrato, Alfredo AU - García-Closas, Reina AU - Lloreta, Josep AU - Malats, Núria AU - Fraumeni, Joseph F AU - Chanock, Stephen J AU - Chatterjee, Nilanjan AU - Rothman, Nathaniel AU - Silverman, Debra T AD - Division of Cancer Epidemiology and Genetics (JDF, SK, JSC, MGC, MCF, DB, PS, LEM, LPO, ARB, AP, JFFJr, SJC, NC, NR, DTS), Experimental Pathology Laboratory, Laboratory of Pathology, Center for Cancer Research (KY, JYC, SMH), and Cancer and Inflammation Program (MLN), National Cancer Institute, Bethesda, MD; Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh Medical School, Edinburgh UK (JDF); CIBERESP, CIBER Epidemiologia y Salud Publica, Madrid, Spain (MK, AT, JL); Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain (MK); Municipal Institute of Medical Research (IMIM-Hospital del Mar), Barcelona, Spain (MK); Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK (MGC); Spanish National Cancer Research Centre (CNIO), Madrid, Spain (FXR, NM); Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain (FXR, CS); Maine Cancer Registry, Augusta, ME (MS); Vermont Cancer Registry, Burlington, VT (AJ); Geisel School of Medicine at Dartmouth, Hanover, NH (MRK, AS); New Hampshire Department of Health and Human Services, Concord, NH (KRA); Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc. (formerly SAIC-Frederick, Inc.), Frederick National Laboratory for Cancer Research, Frederick, MD (PL); Molecular Epidemiology Group, Instituto Universitario de Oncologia, Universidad de Oviedo, Oviedo, Asturias, Spain (AT); Hospital Ramón y Cajal, Elche, Madrid, Spain (AC); Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain (RGC). Y1 - 2015/11// PY - 2015 DA - November 2015 VL - 107 IS - 11 KW - Microtubule-Associated Proteins KW - 0 KW - TACC3 protein, human KW - TMEM129 protein, human KW - EC 2.3.2.27 KW - Ubiquitin-Protein Ligases KW - UGT1A1 enzyme KW - EC 2.4.1.- KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - FGFR3 protein, human KW - EC 2.7.10.1 KW - Receptor, Fibroblast Growth Factor, Type 3 KW - Index Medicus KW - Glucuronosyltransferase -- genetics KW - Receptor, Fibroblast Growth Factor, Type 3 -- genetics KW - Humans KW - Aged KW - Glutathione Transferase -- genetics KW - Scotland -- epidemiology KW - Gene Deletion KW - Microtubule-Associated Proteins -- genetics KW - Risk Factors KW - Ubiquitin-Protein Ligases -- genetics KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Genetic Predisposition to Disease KW - Germ-Line Mutation KW - Female KW - Male KW - Metallurgy KW - Polymorphism, Single Nucleotide KW - Occupational Diseases -- genetics KW - Urinary Bladder Neoplasms -- etiology KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Gene-Environment Interaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1713526828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Modification+of+Occupational+Exposures+on+Bladder+Cancer+Risk+by+Common+Genetic+Polymorphisms.&rft.au=Figueroa%2C+Jonine+D%3BKoutros%2C+Stella%3BColt%2C+Joanne+S%3BKogevinas%2C+Manolis%3BGarcia-Closas%2C+Montserrat%3BReal%2C+Francisco+X%3BFriesen%2C+Melissa+C%3BBaris%2C+Dalsu%3BStewart%2C+Patricia%3BSchwenn%2C+Molly%3BJohnson%2C+Alison%3BKaragas%2C+Margaret+R%3BArmenti%2C+Karla+R%3BMoore%2C+Lee+E%3BSchned%2C+Alan%3BLenz%2C+Petra%3BProkunina-Olsson%2C+Ludmila%3BBanday%2C+A+Rouf%3BPaquin%2C+Ashley%3BYlaya%2C+Kris%3BChung%2C+Joon-Yong%3BHewitt%2C+Stephen+M%3BNickerson%2C+Michael+L%3BTard%C3%B3n%2C+Adonina%3BSerra%2C+Consol%3BCarrato%2C+Alfredo%3BGarc%C3%ADa-Closas%2C+Reina%3BLloreta%2C+Josep%3BMalats%2C+N%C3%BAria%3BFraumeni%2C+Joseph+F%3BChanock%2C+Stephen+J%3BChatterjee%2C+Nilanjan%3BRothman%2C+Nathaniel%3BSilverman%2C+Debra+T&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2015-11-01&rft.volume=107&rft.issue=11&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/10.1093%2Fjnci%2Fdjv223 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-06 N1 - Date created - 2015-09-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Genet. 2010 Nov;42(11):978-84 [20972438] Occup Environ Med. 2011 Apr;68(4):239-49 [20864470] Pharmacogenet Genomics. 2011 Apr;21(4):231-6 [20739907] J Natl Cancer Inst. 2011 Jul 6;103(13):1037-48 [21705679] Hum Mol Genet. 2011 Nov 1;20(21):4268-81 [21750109] Hum Mol Genet. 2011 Nov 1;20(21):4282-9 [21824976] Hum Mol Genet. 2012 Apr 15;21(8):1918-30 [22228101] Am J Epidemiol. 2012 Dec 1;176(11):1060-7 [23118105] Cancer Res. 2013 Apr 1;73(7):2211-20 [23536561] Hum Mol Genet. 2014 Mar 1;23(5):1387-98 [24163127] Occup Environ Med. 2014 Oct;71(10):667-74 [25201311] Am J Epidemiol. 2002 Jul 15;156(2):95-109 [12117698] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Occup Environ Med. 2008 May;65(5):347-53 [17951336] Nat Genet. 2008 Nov;40(11):1307-12 [18794855] Nat Genet. 2009 Feb;41(2):221-7 [19151717] Nat Genet. 2009 Sep;41(9):991-5 [19648920] J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61 [19917915] Nat Genet. 2010 May;42(5):415-9 [20348956] Pharmacogenet Genomics. 2009 Nov;19(11):903-6 [19801959] Comment In: J Natl Cancer Inst. 2016 Mar;108(3). pii: djv441. doi: 10.1093/jnci/djv441 [26857138] J Natl Cancer Inst. 2016 Mar;108(3). pii: djv440. doi: 10.1093/jnci/djv440 [26857137] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jnci/djv223 ER - TY - CPAPER T1 - Healthy People 2020: Laying the foundation for addressing social determinants of health and health equity T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772200; 6365816 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Blakey, Carter Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Healthy+People+2020%3A+Laying+the+foundation+for+addressing+social+determinants+of+health+and+health+equity&rft.au=Blakey%2C+Carter&rft.aulast=Blakey&rft.aufirst=Carter&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - I Can Do It, You Can Do It!: Empowering People with Disabilities to Lead Healthy, Active Lives T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772168; 6365063 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Darensbourg, Lauren Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Disabilities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=I+Can+Do+It%2C+You+Can+Do+It%21%3A+Empowering+People+with+Disabilities+to+Lead+Healthy%2C+Active+Lives&rft.au=Darensbourg%2C+Lauren&rft.aulast=Darensbourg&rft.aufirst=Lauren&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Does Partner Support Improve Pregnancy Outcomes for Mistimed Births among Black Teen Mothers? T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772109; 6367885 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Cai, Beiyi AU - Banerjee, Deborah Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Birth KW - Parturition KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Does+Partner+Support+Improve+Pregnancy+Outcomes+for+Mistimed+Births+among+Black+Teen+Mothers%3F&rft.au=Cai%2C+Beiyi%3BBanerjee%2C+Deborah&rft.aulast=Cai&rft.aufirst=Beiyi&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Cervical cancer screening rates outcomes in federally funded community health centers through patient-centered medical home transformation T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772106; 6365112 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Chienshy Lin, Sue Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Transformation KW - Screening KW - Cervical cancer KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Cervical+cancer+screening+rates+outcomes+in+federally+funded+community+health+centers+through+patient-centered+medical+home+transformation&rft.au=Chienshy+Lin%2C+Sue&rft.aulast=Chienshy+Lin&rft.aufirst=Sue&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Online Learning for Providers: Teaching patient-centered health literacy strategies for individualizing care among patients with diabetes to prevent adverse drug events T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772041; 6365443 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Lier, Silje AU - Rider, Briana Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Diabetes mellitus KW - Learning KW - Education KW - Drugs KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Online+Learning+for+Providers%3A+Teaching+patient-centered+health+literacy+strategies+for+individualizing+care+among+patients+with+diabetes+to+prevent+adverse+drug+events&rft.au=Lier%2C+Silje%3BRider%2C+Briana&rft.aulast=Lier&rft.aufirst=Silje&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Maternal, Infant and Early Childhood Home Visiting Program: Evidence-based home visiting programs and the Role of Home Visitors T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771695; 6367942 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Kilbane, Kathleen Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Children KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Maternal%2C+Infant+and+Early+Childhood+Home+Visiting+Program%3A+Evidence-based+home+visiting+programs+and+the+Role+of+Home+Visitors&rft.au=Kilbane%2C+Kathleen&rft.aulast=Kilbane&rft.aufirst=Kathleen&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - A Method to Improve Population Health: Consider Primary Care/Public Health Integration T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771410; 6367798 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Culver, Martha AU - Jackson, Princess Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Integration KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=A+Method+to+Improve+Population+Health%3A+Consider+Primary+Care%2FPublic+Health+Integration&rft.au=Culver%2C+Martha%3BJackson%2C+Princess&rft.aulast=Culver&rft.aufirst=Martha&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Teaching Self-efficacy in Managing Disease: A Healthcare Cost Cutting Measure T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771237; 6365789 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Selexman, LaTosha AU - Cai, Beiyi Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Education KW - Health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Teaching+Self-efficacy+in+Managing+Disease%3A+A+Healthcare+Cost+Cutting+Measure&rft.au=Selexman%2C+LaTosha%3BCai%2C+Beiyi&rft.aulast=Selexman&rft.aufirst=LaTosha&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Real Cost: The U.S. Food and Drug Administration's Youth Tobacco Prevention Campaign T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731769426; 6364831 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Crosby, Kathleen Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Prevention KW - Tobacco KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731769426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Deciphering+the+underlying+mechanisms+of+oxidation-state+dependent+cytotoxicity+of+graphene+oxide+on+mammalian+cells.&rft.au=Zhang%2C+Wendi%3BYan%2C+Liang%3BLi%2C+Meng%3BZhao%2C+Ruisheng%3BYang%2C+Xiao%3BJi%2C+Tianjiao%3BGu%2C+Zhanjun%3BYin%2C+Jun-Jie%3BGao%2C+Xingfa%3BNie%2C+Guangjun&rft.aulast=Zhang&rft.aufirst=Wendi&rft.date=2015-09-02&rft.volume=237&rft.issue=2&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2015.05.021 L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - National Viral Hepatitis Action Plan T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731768404; 6366762 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Dan, Corinna Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Hepatitis A UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731768404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=National+Viral+Hepatitis+Action+Plan&rft.au=Dan%2C+Corinna&rft.aulast=Dan&rft.aufirst=Corinna&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Implementation of Telehealth among Behavioral Health Providers Serving Rural and Hard to Reach Populations T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731768227; 6366491 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Simmons, Dantrell Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Rural areas UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731768227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Implementation+of+Telehealth+among+Behavioral+Health+Providers+Serving+Rural+and+Hard+to+Reach+Populations&rft.au=Simmons%2C+Dantrell&rft.aulast=Simmons&rft.aufirst=Dantrell&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - National Action Plan for the Prevention, Care, & Treatment of Viral Hepatitis - A policy framework for public health action on hepatitis C T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731768203; 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6366517 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Cobb-Souza, Sonsiere Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Social aspects KW - Hepatitis C KW - Ethnic groups KW - Hepatitis C virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731768153?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Hepatitis+C+virus+in+African+American+communities%3A+Opportunities+and+strategies+to+increase+engagement+to+reduce+disparities&rft.au=Cobb-Souza%2C+Sonsiere&rft.aulast=Cobb-Souza&rft.aufirst=Sonsiere&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Analysis of overall impact scoring trends within AHRQ peer review study sections T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731768015; 6366535 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Quiggle, Gabrielle AU - Trocki, Rebecca AU - Wadhwani, Kishena AU - Chesley, Francis Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731768015?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Analysis+of+overall+impact+scoring+trends+within+AHRQ+peer+review+study+sections&rft.au=Quiggle%2C+Gabrielle%3BTrocki%2C+Rebecca%3BWadhwani%2C+Kishena%3BChesley%2C+Francis&rft.aulast=Quiggle&rft.aufirst=Gabrielle&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Developing Healthy People 2030: Engaging Multiple Partners and Influencing Policy T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731766825; 6367487 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Ochiai, Emmeline AU - Roper, Allison Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731766825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Developing+Healthy+People+2030%3A+Engaging+Multiple+Partners+and+Influencing+Policy&rft.au=Ochiai%2C+Emmeline%3BRoper%2C+Allison&rft.aulast=Ochiai&rft.aufirst=Emmeline&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Healthy People 2020 and Social Determinants of Health: Eliminating Barriers to and Improving Social Determinants of Health T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731766792; 6367485 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Ochiai, Emmeline Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Barriers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731766792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Healthy+People+2020+and+Social+Determinants+of+Health%3A+Eliminating+Barriers+to+and+Improving+Social+Determinants+of+Health&rft.au=Ochiai%2C+Emmeline&rft.aulast=Ochiai&rft.aufirst=Emmeline&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Addressing social determinants to achieve health equity: A regional perspective T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731765684; 6365817 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Lando, James Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731765684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Addressing+social+determinants+to+achieve+health+equity%3A+A+regional+perspective&rft.au=Lando%2C+James&rft.aulast=Lando&rft.aufirst=James&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Health Disparity Data Tool: An innovative instrument to explore health disparities with DATA2020 T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731765507; 6366333 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Wendt, Minh AU - Hoyer, Deborah AU - Dorsey, Rashida Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Data processing KW - Innovations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731765507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Health+Disparity+Data+Tool%3A+An+innovative+instrument+to+explore+health+disparities+with+DATA2020&rft.au=Wendt%2C+Minh%3BHoyer%2C+Deborah%3BDorsey%2C+Rashida&rft.aulast=Wendt&rft.aufirst=Minh&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - San Diego County's Live Well @ Work Initiative: Advancing Employee Health through Policy, Systems and Environmental Change T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731765496; 6365748 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Blevins, Chesley AU - Thompson, Kelley AU - Melendrez, Blanca AU - Browner, Deirdre AU - McDermid, Lindsey AU - Wooten, Wilma AU - Coleman, Thomas Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Policies KW - Personnel KW - Climatic changes KW - Environmental changes KW - USA, California, San Diego Cty. 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6366330 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Ejike-King, Lacreisha AU - Dorsey, Rashida Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Health care KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731765467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=An+Assessment+of+the+Implementation+of+the+National+Standards+for+Culturally+and+Linguistically+Appropriate+Services+in+Health+and+Health+Care+within+the+U.S.+Department+of+Health+and+Human+Services&rft.au=Ejike-King%2C+Lacreisha%3BDorsey%2C+Rashida&rft.aulast=Ejike-King&rft.aufirst=Lacreisha&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - SOAR to Health and Wellness: A New Federal Training on Human Trafficking for Health Care Providers T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764862; 6367721 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Rollins, Rochelle Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Human trafficking KW - Health care KW - Training KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=SOAR+to+Health+and+Wellness%3A+A+New+Federal+Training+on+Human+Trafficking+for+Health+Care+Providers&rft.au=Rollins%2C+Rochelle&rft.aulast=Rollins&rft.aufirst=Rochelle&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Control of Worker Exposure to Silica in Oil and Gas Extraction T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764851; 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6367452 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Ridl, Sophia AU - Retzer, Kyla AU - Hill, Ryan Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Mortality KW - Oil and gas industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Development+of+an+Oil+and+Gas+Worker+Fatality+Surveillance+System&rft.au=Ridl%2C+Sophia%3BRetzer%2C+Kyla%3BHill%2C+Ryan&rft.aulast=Ridl&rft.aufirst=Sophia&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Developing Informatics Tools for the Evaluation of Large Health Data Sets T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764762; 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6367450 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - King, Bradley AU - Esswein, Eric AU - Snawder, John AU - Breitenstein, Michael AU - Alexander-Scott, Marissa Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Oil and gas industry KW - Upstream UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=NIOSH+Exposure+Assessments+in+the+Upstream+Oil+and+Gas+Industry%3A+Exposures+during+Flowback+and+Production+Testing+Operations&rft.au=King%2C+Bradley%3BEsswein%2C+Eric%3BSnawder%2C+John%3BBreitenstein%2C+Michael%3BAlexander-Scott%2C+Marissa&rft.aulast=King&rft.aufirst=Bradley&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Expanding Healthy People through the Leading Health Indicators and the Foundation Health Measures to Impact T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764728; 6367486 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Hoyer, Deborah Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Expanding+Healthy+People+through+the+Leading+Health+Indicators+and+the+Foundation+Health+Measures+to+Impact&rft.au=Hoyer%2C+Deborah&rft.aulast=Hoyer&rft.aufirst=Deborah&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Effective Healthy People 2020 Resources to Influence a Health in All Policies Approach to Policy and Program Development T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764690; 6367484 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Devine, Theresa Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Resource development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Effective+Healthy+People+2020+Resources+to+Influence+a+Health+in+All+Policies+Approach+to+Policy+and+Program+Development&rft.au=Devine%2C+Theresa&rft.aulast=Devine&rft.aufirst=Theresa&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Evaluating the National Standards for Culturally and Linguistically Appropriate Services in Health and Health Care T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764663; 6367321 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Dorsey, Rashida AU - Ejike-King, Lacreisha AU - Barksdale, Crystal Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=Urogenital+Chlamydia+trachomatis+strain+types%2C+defined+by+high-resolution+multilocus+sequence+typing%2C+in+relation+to+ethnicity+and+urogenital+symptoms+among+a+young+screening+population+in+Amsterdam%2C+The+Netherlands&rft.au=Versteeg%2C+Bart%3BHimschoot%2C+Michelle%3Bvan+den+Broek%2C+Ingrid+V+F%3BBom%2C+Reinier+J+M%3BSpeksnijder%2C+Arjen+G+C+L%3BSchim+van+der+Loeff%2C+Maarten+F%3BBruisten%2C+Sylvia+M&rft.aulast=Versteeg&rft.aufirst=Bart&rft.date=2015-09-16&rft.volume=91&rft.issue=6&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/10.1136%2Fsextrans-2014-051790 L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Translating Legal and Policy Evidence and Data for Health Impact: The Healthy People 2020 Law and Health Policy Project T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764294; 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6366131 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Shinn, Carolynne AU - Anderson, Laurie AU - Adeney, Kathryn AU - Krause, L AU - Safranek, Sarah AU - Buckner-Brown, Joyce Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Reviews KW - Intervention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731763790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=%27Black+Box%27+surrounding+community+coalition-led+interventions+to+reduce+health+disparities+in+racial+and+ethnic+minority+populations%3A+Excerpts+from+a+Cochrane+systematic+review&rft.au=Shinn%2C+Carolynne%3BAnderson%2C+Laurie%3BAdeney%2C+Kathryn%3BKrause%2C+L%3BSafranek%2C+Sarah%3BBuckner-Brown%2C+Joyce&rft.aulast=Shinn&rft.aufirst=Carolynne&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Healthy Fun for All Festivals: Policy for Social Norms Change T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731762999; 6364898 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Hernandez, Rocio AU - Rockas, Theresa Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Policies KW - Social interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731762999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Healthy+Fun+for+All+Festivals%3A+Policy+for+Social+Norms+Change&rft.au=Hernandez%2C+Rocio%3BRockas%2C+Theresa&rft.aulast=Hernandez&rft.aufirst=Rocio&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Developing and Administering a Health Survey in the Asian Indian Community in Houston T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731762701; 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6367207 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Steege, Andrea AU - Boiano, Jim AU - Haring Sweeney, Marie Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Smoke KW - Surgery KW - Safety KW - Health and safety KW - Medical personnel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Surgical+Smoke+and+Healthcare+Worker+Health+and+Safety&rft.au=Steege%2C+Andrea%3BBoiano%2C+Jim%3BHaring+Sweeney%2C+Marie&rft.aulast=Steege&rft.aufirst=Andrea&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Association between Health Care Access Quality Indicators and Emergency Department Use among Children with Developmental Disabilities in the US T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760146; 6367059 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Chienshy Lin, Sue Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Health care KW - Disabilities KW - Emergencies KW - Children KW - Emergency medical services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Association+between+Health+Care+Access+Quality+Indicators+and+Emergency+Department+Use+among+Children+with+Developmental+Disabilities+in+the+US&rft.au=Chienshy+Lin%2C+Sue&rft.aulast=Chienshy+Lin&rft.aufirst=Sue&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Mental health professionals' attitude and perception of their role in tackling substance abuse and related disorders in Nigeria T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760145; 6367142 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Akinola, Olubusayo AU - Kuo, Wen-Hung AU - Oswald, John AU - Fulton, Lawrence AU - Obisesan, Olawunmi Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Mental disorders KW - Attitudes KW - Nigeria KW - Perception KW - Experts KW - Drug abuse KW - Substance abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Mental+health+professionals%27+attitude+and+perception+of+their+role+in+tackling+substance+abuse+and+related+disorders+in+Nigeria&rft.au=Akinola%2C+Olubusayo%3BKuo%2C+Wen-Hung%3BOswald%2C+John%3BFulton%2C+Lawrence%3BObisesan%2C+Olawunmi&rft.aulast=Akinola&rft.aufirst=Olubusayo&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - National Institute for Occupational Safety and Health (NIOSH) Oil and Gas Extraction Safety and Health Program: Lessons in How Partnerships Drive Quality Research T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760136; 6367449 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Alexander-Scott, Marissa Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Oil and gas industry KW - Occupational safety KW - Safety KW - Health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=National+Institute+for+Occupational+Safety+and+Health+%28NIOSH%29+Oil+and+Gas+Extraction+Safety+and+Health+Program%3A+Lessons+in+How+Partnerships+Drive+Quality+Research&rft.au=Alexander-Scott%2C+Marissa&rft.aulast=Alexander-Scott&rft.aufirst=Marissa&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - JOUR T1 - The commensal infant gut meta-mobilome as a potential reservoir for persistent multidrug resistance integrons. AN - 1728256516; 26507767 AB - Despite the accumulating knowledge on the development and establishment of the gut microbiota, its role as a reservoir for multidrug resistance is not well understood. This study investigated the prevalence and persistence patterns of an integrase gene (int1), used as a proxy for integrons (which often carry multiple antimicrobial resistance genes), in the fecal microbiota of 147 mothers and their children sampled longitudinally from birth to 2 years. The study showed the int1 gene was detected in 15% of the study population, and apparently more persistent than the microbial community structure itself. We found int1 to be persistent throughout the first two years of life, as well as between mothers and their 2-year-old children. Metagenome sequencing revealed integrons in the gut meta-mobilome that were associated with plasmids and multidrug resistance. In conclusion, the persistent nature of integrons in the infant gut microbiota makes it a potential reservoir of mobile multidrug resistance. JF - Scientific reports AU - Ravi, Anuradha AU - Avershina, Ekaterina AU - Foley, Steven L AU - Ludvigsen, Jane AU - Storrø, Ola AU - Øien, Torbjørn AU - Johnsen, Roar AU - McCartney, Anne L AU - L'Abée-Lund, Trine M AU - Rudi, Knut AD - Norwegian University of Life Sciences, Chemistry, Biotechnology and Food science department (IKBM), Campus Ås, Ås 1432, Norway. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Division of Microbiology, Jefferson, AR 72079. ; Department of Public Health and General Practice, Norwegian University of Science and Technology, 9491 Trondheim, Norway. ; Microbial Ecology &Health Group, Department of Food and Nutritional Sciences, University of Reading, Reading, UK. ; Norwegian University of Life Sciences, Department of Food safety and Infection Biology, Campus Adamstuen, Oslo 0454, Norway. Y1 - 2015/10/28/ PY - 2015 DA - 2015 Oct 28 SP - 15317 VL - 5 KW - DNA, Bacterial KW - 0 KW - Integrases KW - EC 2.7.7.- KW - Index Medicus KW - Infant KW - Humans KW - Infant, Newborn KW - Bacterial Physiological Phenomena KW - Female KW - Pregnancy KW - Bacteria -- metabolism KW - Bacteria -- genetics KW - Symbiosis KW - Integrons KW - Drug Resistance, Multiple, Bacterial -- genetics KW - Integrases -- genetics KW - Gastrointestinal Tract -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728256516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=The+commensal+infant+gut+meta-mobilome+as+a+potential+reservoir+for+persistent+multidrug+resistance+integrons.&rft.au=Ravi%2C+Anuradha%3BAvershina%2C+Ekaterina%3BFoley%2C+Steven+L%3BLudvigsen%2C+Jane%3BStorr%C3%B8%2C+Ola%3B%C3%98ien%2C+Torbj%C3%B8rn%3BJohnsen%2C+Roar%3BMcCartney%2C+Anne+L%3BL%27Ab%C3%A9e-Lund%2C+Trine+M%3BRudi%2C+Knut&rft.aulast=Ravi&rft.aufirst=Anuradha&rft.date=2015-10-28&rft.volume=5&rft.issue=&rft.spage=15317&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep15317 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-17 N1 - Date created - 2015-10-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: PLoS One. 2011;6(6):e21644 [21738748] Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33 [20805405] Nature. 2011 Dec 8;480(7376):241-4 [22037308] Bioinformatics. 2012 Jun 15;28(12):1647-9 [22543367] Nature. 2012 Jun 14;486(7402):222-7 [22699611] Genome Res. 2012 Oct;22(10):1985-94 [22732228] Appl Environ Microbiol. 2013 Jan;79(2):497-507 [23124244] PLoS One. 2013;8(2):e57923 [23460914] Science. 2013 Jul 5;341(6141):1237439 [23828941] BMC Bioinformatics. 2008;9:386 [18803844] Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):652-7 [11209061] Mol Microbiol. 2001 Nov;42(3):587-601 [11722728] Microbiology. 2002 Jan;148(Pt 1):257-66 [11782518] Antimicrob Agents Chemother. 2003 Apr;47(4):1285-90 [12654659] Clin Microbiol Infect. 2004 Apr;10(4):272-88 [15059115] Proc Natl Acad Sci U S A. 2004 May 4;101(18):7118-22 [15107498] FEMS Microbiol Lett. 1998 Apr 1;161(1):125-8 [9561739] Biotechnol Bioeng. 2005 Mar 20;89(6):670-9 [15696537] Curr Microbiol. 2005 Oct;51(4):270-4 [16187156] Appl Environ Microbiol. 2006 Jul;72(7):5069-72 [16820507] Nat Rev Microbiol. 2006 Aug;4(8):608-20 [16845431] Nature. 2013 Jul 11;499(7457):219-22 [23748443] Nat Commun. 2013;4:2151 [23877117] Benef Microbes. 2013 Sep;4(3):219-22 [23887030] Nature. 2013 Jul 25;499(7459):394-6 [23887414] PLoS One. 2013;8(11):e78822 [24236055] Nucleic Acids Res. 2014 Jan;42(Database issue):D581-91 [24225323] FEMS Microbiol Ecol. 2014 Jan;87(1):280-90 [24112053] ISME J. 2015 Jun;9(6):1269-79 [25500508] Trends Microbiol. 2007 Jul;15(7):301-9 [17566739] Antimicrob Agents Chemother. 2000 May;44(5):1315-21 [10770768] ISME J. 2009 Feb;3(2):209-15 [18923456] PLoS Biol. 2007 Jul;5(7):e177 [17594176] Science. 2009 Aug 28;325(5944):1128-31 [19713526] Ann Clin Microbiol Antimicrob. 2009;8:34 [19995422] Nat Methods. 2010 May;7(5):335-6 [20383131] Physiol Rev. 2010 Jul;90(3):859-904 [20664075] Int J Food Microbiol. 2011 Oct 3;149(3):274-7 [21802160] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep15317 ER - TY - JOUR T1 - Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. AN - 1727993183; 26499117 AB - Exposure to dichlorvos (DDVP), an organophosphorus pesticide, is known to result in neurotoxicity as well as other metabolic perturbations. However, the molecular causes of DDVP toxicity are poorly understood, especially in cells other than neurons and muscle cells. To obtain a better understanding of the process of non-neuronal DDVP toxicity, we exposed zebrafish to different concentrations of DDVP, and investigated the resulting changes in liver histology and gene transcription. Functional enrichment analysis of genes affected by DDVP exposure identified a number of processes involved in energy utilization and stress response in the liver. The abundance of transcripts for proteins involved in glucose metabolism was profoundly affected, suggesting that carbon flux might be diverted toward the pentose phosphate pathway to compensate for an elevated demand for energy and reducing equivalents for detoxification. Strikingly, many transcripts for molecules involved in β-oxidation and fatty acid synthesis were down-regulated. We found increases in message levels for molecules involved in reactive oxygen species responses as well as ubiquitination, proteasomal degradation, and autophagy. To ensure that the effects of DDVP on energy metabolism were not simply a consequence of poor feeding because of neuromuscular impairment, we fasted fish for 29 or 50 h and analyzed liver gene expression in them. The patterns of gene expression for energy metabolism in fasted and DDVP-exposed fish were markedly different. We observed coordinated changes in the expression of a large number of genes involved in energy metabolism and responses to oxidative stress. These results argue that an appreciable part of the effect of DDVP is on energy metabolism and is regulated at the message level. Although we observed some evidence of neuromuscular impairment in exposed fish that may have resulted in reduced feeding, the alterations in gene expression in exposed fish cannot readily be explained by nutrient deprivation. JF - BMC genomics AU - Bui-Nguyen, Tri M AU - Baer, Christine E AU - Lewis, John A AU - Yang, Dongren AU - Lein, Pamela J AU - Jackson, David A AD - ORISE Postdoctoral Fellow, Fort Detrick, MD, 21702, USA. Tri.Bui-Nguyen@fda.hhs.gov. ; Excet, Inc., Springfield, VA, 22151, USA. christine.e.baer2.ctr@mail.mil. ; US Army Center for Environmental Health Research, Fort Detrick, MD, 21702, USA. john.a.lewis5.civ@mail.mil. ; Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, 95616, USA. mryang@ucdavis.edu. ; Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, 95616, USA. pjlein@ucdavis.edu. ; US Army Center for Environmental Health Research, Fort Detrick, MD, 21702, USA. david.a.jackson17.civ@mail.mil. Y1 - 2015/10/24/ PY - 2015 DA - 2015 Oct 24 SP - 853 VL - 16 KW - Insecticides KW - 0 KW - Reactive Oxygen Species KW - Dichlorvos KW - 7U370BPS14 KW - Cholinesterases KW - EC 3.1.1.8 KW - Index Medicus KW - Animals KW - Reactive Oxygen Species -- metabolism KW - Lipid Metabolism -- genetics KW - Models, Biological KW - Carbohydrate Metabolism -- genetics KW - Cholinesterases -- metabolism KW - Gene Expression Profiling KW - Apoptosis -- genetics KW - Unfolded Protein Response KW - Signal Transduction -- drug effects KW - Enzyme Activation -- drug effects KW - Oxidative Stress -- drug effects KW - Gene Expression Regulation -- drug effects KW - Cluster Analysis KW - Insecticides -- toxicity KW - Liver -- pathology KW - Zebrafish -- metabolism KW - Liver -- drug effects KW - Dichlorvos -- toxicity KW - Energy Metabolism -- drug effects KW - Energy Metabolism -- genetics KW - Liver -- metabolism KW - Zebrafish -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727993183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Dichlorvos+exposure+results+in+large+scale+disruption+of+energy+metabolism+in+the+liver+of+the+zebrafish%2C+Danio+rerio.&rft.au=Bui-Nguyen%2C+Tri+M%3BBaer%2C+Christine+E%3BLewis%2C+John+A%3BYang%2C+Dongren%3BLein%2C+Pamela+J%3BJackson%2C+David+A&rft.aulast=Bui-Nguyen&rft.aufirst=Tri&rft.date=2015-10-24&rft.volume=16&rft.issue=&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2Fs12864-015-1941-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-30 N1 - Date created - 2015-10-27 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - GSE66257; GEO N1 - SuppNotes - Cited By: J Cell Biol. 2008 Aug 25;182(4):663-73 [18725537] Physiol Biochem Zool. 2008 Nov-Dec;81(6):762-74 [18947325] Physiol Genomics. 2008 Nov 12;35(3):283-95 [18728227] Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20567-74 [19074260] J Immunol. 2009 Apr 15;182(8):4917-30 [19342671] Mutagenesis. 2009 May;24(3):211-24 [19153097] Toxicology. 2010 Apr 11;270(2-3):77-84 [20132858] Genes Cells. 2010 Sep 1;15(9):923-33 [20670274] Pathol Res Pract. 2010 Sep 15;206(9):631-41 [20591579] Indian J Exp Biol. 2010 Jul;48(7):697-709 [20929053] Mol Brain. 2010;3:35 [21073741] Science. 2010 Dec 3;330(6009):1344-8 [21127245] Toxicol Sci. 2011 Oct;123(2):590-600 [21775727] Biochem J. 1986 Jun 15;236(3):635-41 [3790084] Exp Parasitol. 1991 May;72(4):355-61 [2026213] Exp Mol Pathol. 1992 Apr;56(2):144-52 [1587340] Toxicol Appl Pharmacol. 1992 Aug;115(2):268-77 [1641860] Pancreas. 1993 Mar;8(2):171-5 [8460092] Mech Dev. 1997 Jul;65(1-2):87-98 [9256347] Gene. 1997 Nov 12;201(1-2):87-98 [9409775] Pharmacol Biochem Behav. 1998 Apr;59(4):1081-6 [9586870] Mol Cell Biol. 1999 Oct;19(10):6825-32 [10490621] Biochem J. 1999 Oct 15;343 Pt 2:487-504 [10510318] Bull Environ Contam Toxicol. 1981 Apr;26(4):453-60 [7236904] Bull Environ Contam Toxicol. 1981 Apr;26(4):496-501 [6786400] J Biol Chem. 1983 Mar 10;258(5):2993-9 [6402507] Environ Res. 1983 Oct;32(1):127-33 [6617605] Am J Physiol. 1957 Feb;188(2):321-6 [13411209] Biochem Pharmacol. 1961 Jul;7:88-95 [13726518] Biochim Biophys Acta. 2004 Nov 29;1695(1-3):171-88 [15571814] Biochem J. 2005 Sep 1;390(Pt 2):521-8 [15890065] Gene. 2005 Aug 15;356:91-100 [15979250] Life Sci. 2006 Jan 25;78(9):1015-20 [16153661] Mol Cell Biol. 2006 Feb;26(3):940-54 [16428448] Regul Toxicol Pharmacol. 2006 Apr;44(3):238-48 [16439043] Physiol Genomics. 2006 Nov 27;27(3):351-61 [16882884] Mol Cell Biochem. 2002 Mar;232(1-2):13-8 [12030370] Am J Physiol Cell Physiol. 2003 Oct;285(4):C806-12 [12773310] Aquat Toxicol. 2003 Dec 10;65(4):337-60 [14568351] Nephrol Nurs J. 2003 Dec;30(6):621-6; quiz 627-8 [14730782] Assay Drug Dev Technol. 2002 Nov;1(1 Pt 1):41-8 [15090155] BMC Bioinformatics. 2004 Feb 18;5:16 [14975175] Comp Biochem Physiol C Toxicol Pharmacol. 2004 Apr;137(4):343-7 [15228952] Neurotoxicol Teratol. 2004 Nov-Dec;26(6):709-18 [15451034] Xenobiotica. 1972 Mar;2(2):107-16 [4560365] Arch Toxikol. 1972;30(1):19-27 [4646170] J Agric Food Chem. 1973 Mar-Apr;21(2):163-6 [4688899] Aust Vet J. 1973 Mar;49(3):113-9 [4707161] Aust Vet J. 1973 Mar;49(3):120-5 [4541016] Hum Exp Toxicol. 2011 Sep;30(9):1119-40 [21071550] Neuromolecular Med. 2011 Dec;13(4):251-65 [21964614] J Inherit Metab Dis. 2008 Apr;31(2):226-9 [18392745] Exp Oncol. 2012 Oct;34(3):286-97 [23070014] Exp Toxicol Pathol. 2012 Nov;64(7-8):821-30 [21458248] Nature. 2013 Apr 25;496(7446):498-503 [23594743] Occup Environ Med. 2014 Apr;71(4):275-81 [24436061] Mol Cell Biochem. 1999 Sep;199(1-2):87-92 [10544956] IUBMB Life. 2000 Feb;49(2):125-30 [10776595] J Physiol. 2000 Nov 15;529 Pt 1:57-68 [11080251] Cell Calcium. 2000 Nov-Dec;28(5-6):339-48 [11115373] Comp Biochem Physiol C Toxicol Pharmacol. 2000 Dec;127(3):233-42 [11246494] Arh Hig Rada Toksikol. 2002 Dec;53(4):275-81 [12828128] J Agric Food Chem. 1976 Mar-Apr;24(2):367-71 [1254816] Toxicol Appl Pharmacol. 1979 Feb;47(2):323-30 [222008] Toxicology. 1981;19(3):239-45 [7233448] Nat Rev Genet. 2007 May;8(5):353-67 [17440532] Physiol Res. 2007;56(2):213-20 [16555951] Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29 [17565364] Biochim Biophys Acta. 2007 Sep;1770(9):1382-94 [17640809] Genome Res. 2007 Oct;17(10):1537-45 [17785539] Trends Cell Biol. 2007 Sep;17(9):422-7 [17804237] J Biol. 2008;7(1):1 [18226191] Lancet. 2008 Feb 16;371(9612):597-607 [17706760] Am J Epidemiol. 2008 May 15;167(10):1235-46 [18343878] Drug Discov Today. 2008 May;13(9-10):394-401 [18468556] Physiol Res. 2008;57(2):261-8 [17298203] Mutat Res. 2008 Jul-Aug;659(1-2):31-9 [18164232] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12864-015-1941-2 ER - TY - JOUR T1 - 24-hour human urine and serum profiles of bisphenol A: Evidence against sublingual absorption following ingestion in soup. AN - 1717472907; 25620055 AB - Extensive first-pass metabolism of ingested bisphenol A (BPA) in the gastro-intestinal tract and liver restricts blood concentrations of bioactive BPA to <1% of total BPA in humans and non-human primates. Absorption of ingested BPA through non-metabolizing tissues of the oral cavity, recently demonstrated in dogs, could lead to the higher serum BPA concentrations reported in some human biomonitoring studies. We hypothesized that the extensive interaction with the oral mucosa by a liquid matrix, like soup, relative to solid food or capsules, might enhance absorption through non-metabolizing oral cavity tissues in humans, producing higher bioavailability and higher serum BPA concentrations. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a 24hour period in 10 adult male volunteers following ingestion of 30μg d6-BPA/kg body weight in soup. Absorption of d6-BPA was rapid (t1/2=0.45h) and elimination of the administered dose was complete 24h post-ingestion, evidence against any tissue depot for BPA. The maximum serum d6-BPA concentration was 0.43nM at 1.6h after administration and represented <0.3% of total d6-BPA. Pharmacokinetic parameters, pharmacokinetic model simulations, and the significantly faster appearance half-life of d6-BPA-glucuronide compared to d6-BPA (0.29h vs 0.45h) were evidence against meaningful absorption of BPA in humans through any non-metabolizing tissue (<1%). This study confirms that typical exposure to BPA in food produces picomolar to subpicomolar serum BPA concentrations in humans, not nM concentrations reported in some biomonitoring studies. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Teeguarden, Justin G AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Yang, Xiaoxia AU - Fisher, Jeffrey W AU - Seryak, Liesel M AU - Doerge, Daniel R AD - Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99352, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 93771, USA. Electronic address: jt@pnl.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: nathan.twaddle@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: mona.churchwell@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: xiaoxia.yang@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: jeffrey.fisher@fda.hhs.gov. ; Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH 43210, USA. Electronic address: seryak.2@osu.edu. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: daniel.doerge@fda.hhs.gov. Y1 - 2015/10/15/ PY - 2015 DA - 2015 Oct 15 SP - 131 EP - 142 VL - 288 IS - 2 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Glucuronides KW - Phenols KW - Sulfates KW - bisphenol A glucuronide KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Bisphenol A KW - Oral KW - Sublingual KW - Exposure KW - Endocrine disruptors KW - Pharmacokinetics KW - Administration, Oral KW - Young Adult KW - Humans KW - Metabolic Clearance Rate KW - Models, Biological KW - Renal Elimination KW - Half-Life KW - Biotransformation KW - Sulfates -- blood KW - Adult KW - Middle Aged KW - Sulfates -- urine KW - Glucuronides -- blood KW - Glucuronides -- urine KW - Male KW - Phenols -- administration & dosage KW - Endocrine Disruptors -- blood KW - Benzhydryl Compounds -- pharmacokinetics KW - Phenols -- blood KW - Phenols -- pharmacokinetics KW - Food Contamination KW - Endocrine Disruptors -- urine KW - Benzhydryl Compounds -- blood KW - Endocrine Disruptors -- pharmacokinetics KW - Endocrine Disruptors -- administration & dosage KW - Phenols -- urine KW - Oral Mucosal Absorption KW - Mouth Mucosa -- metabolism KW - Benzhydryl Compounds -- administration & dosage KW - Benzhydryl Compounds -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717472907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=24-hour+human+urine+and+serum+profiles+of+bisphenol+A%3A+Evidence+against+sublingual+absorption+following+ingestion+in+soup.&rft.au=Teeguarden%2C+Justin+G%3BTwaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BYang%2C+Xiaoxia%3BFisher%2C+Jeffrey+W%3BSeryak%2C+Liesel+M%3BDoerge%2C+Daniel+R&rft.aulast=Teeguarden&rft.aufirst=Justin&rft.date=2015-10-15&rft.volume=288&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.01.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-13 N1 - Date created - 2015-09-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.01.009 ER - TY - JOUR T1 - Occupational characteristics and the progression of carotid artery intima-media thickness and plaque over 9years: the Multi-Ethnic Study of Atherosclerosis (MESA) AN - 1808709175; PQ0003421142 AB - ObjectivesThe role of occupation in the development of cardiovascular disease (CVD) remains a topic of research because few studies have examined longitudinal associations, and because occupation can be an indicator of socioeconomic position (SEP) and a proxy for hazard exposure. This study examines associations of occupational category as an SEP marker and selected occupational exposures with progression of the subclinical carotid artery disease.MethodsA community-based, multiethnic sample (n=3109, mean age=60.2) provided subclinical CVD measures at least twice at three data collection points (mean follow-up=9.4years). After accounting for demographic characteristics, SEP, and traditional CVD risk factors, we modelled common carotid intima-media thickness, carotid plaque scores, and carotid plaque shadowing as a function of occupational category, physical hazard exposure, physical activity on the job, interpersonal stress, job control and job demands. These job characteristics were derived from the Occupational Resource Network (O*NET). Random coefficient models were used to account for repeated measures and time-varying covariates.ResultsThere were a few statistically significant associations at baseline. After all covariates were included in the model, men in management, office/sales, service and blue-collar jobs had 28-44% higher plaque scores than professionals at baseline (p=0.001). Physically hazardous jobs were positively associated with plaque scores among women (p=0.014). However, there were no significant longitudinal associations between any of the occupational characteristics and any of the subclinical CVD measures.ConclusionsThere was little evidence that the occupational characteristics examined in this study accelerated the progression of subclinical CVD. JF - Occupational and Environmental Medicine AU - Fujishiro, Kaori AU - Diez Roux, Ana V AU - Landsbergis, Paul AU - Kaufman, Joel D AU - Korcarz, Claudia E AU - Stein, James H AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/10/12/ PY - 2015 DA - 2015 Oct 12 SP - 690 EP - 698 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 72 IS - 10 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Data collection KW - Community involvement KW - Physical activity KW - Statistical analysis KW - Stress KW - Socioeconomics KW - Data collections KW - Arteriosclerosis KW - Models KW - Demography KW - Somatosensory evoked potentials KW - Socio-economic aspects KW - Risk factors KW - Carotid artery KW - Mesas KW - Plaques KW - Cardiovascular diseases KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808709175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupational+characteristics+and+the+progression+of+carotid+artery+intima-media+thickness+and+plaque+over+9years%3A+the+Multi-Ethnic+Study+of+Atherosclerosis+%28MESA%29&rft.au=Fujishiro%2C+Kaori%3BDiez+Roux%2C+Ana+V%3BLandsbergis%2C+Paul%3BKaufman%2C+Joel+D%3BKorcarz%2C+Claudia+E%3BStein%2C+James+H&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2015-10-12&rft.volume=72&rft.issue=10&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102311 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Physical activity; Statistical analysis; Arteriosclerosis; Data collections; Models; Somatosensory evoked potentials; Demography; Socio-economic aspects; Risk factors; Carotid artery; Plaques; Cardiovascular diseases; Occupational exposure; Data collection; Community involvement; Socioeconomics; Stress; Mesas DO - http://dx.doi.org/10.1136/oemed-2014-102311 ER - TY - JOUR T1 - Exposure-response relationships for select cancer and non-cancer health outcomes in a cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950-2009) AN - 1808617203; PQ0003421143 AB - ObjectivesTo examine exposure-response relationships between surrogates of firefighting exposure and select outcomes among previously studied US career firefighters.MethodsEight cancer and four non-cancer outcomes were examined using conditional logistic regression. Incidence density sampling was used to match each case to 200 controls on attained age. Days accrued in firefighting assignments (exposed-days), run totals (fire-runs) and run times (fire-hours) were used as exposure surrogates. HRs comparing 75th and 25th centiles of lagged cumulative exposures were calculated using loglinear, linear, log-quadratic, power and restricted cubic spline general relative risk models. Piecewise constant models were used to examine risk differences by time since exposure, age at exposure and calendar period.ResultsAmong 19309 male firefighters eligible for the study, there were 1333 cancer deaths and 2609 cancer incidence cases. Significant positive associations between fire-hours and lung cancer mortality and incidence were evident. A similar relation between leukaemia mortality and fire-runs was also found. The lung cancer associations were nearly linear in cumulative exposure, while the association with leukaemia mortality was attenuated at higher exposure levels and greater for recent exposures. Significant negative associations were evident for the exposure surrogates and colorectal and prostate cancers, suggesting a healthy worker survivor effect possibly enhanced by medical screening.ConclusionsLung cancer and leukaemia mortality risks were modestly increasing with firefighter exposures. These findings add to evidence of a causal association between firefighting and cancer. Nevertheless, small effects merit cautious interpretation. We plan to continue to follow the occurrence of disease and injury in this cohort. JF - Occupational and Environmental Medicine AU - Daniels, Robert D AU - Bertke, Stephen AU - Dahm, Matthew M AU - Yiin, James H AU - Kubale, Travis L AU - Hales, Thomas R AU - Baris, Dalsu AU - Zahm, Shelia H AU - Beaumont, James J AU - Waters, Kathleen M AU - Pinkerton, Lynne E AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/10/11/ PY - 2015 DA - 2015 Oct 11 SP - 699 EP - 706 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 72 IS - 10 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - USA, Illinois, Chicago KW - Risk assessment KW - Age KW - Injuries KW - Models KW - Leukemia KW - Dose-response effects KW - Sampling KW - Occupational exposure KW - Lung cancer KW - Mortality KW - USA, Pennsylvania, Philadelphia KW - Careers KW - Cancer KW - Health risks KW - Prostate cancer KW - Firefighter services KW - INE, USA, California, San Francisco KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808617203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Exposure-response+relationships+for+select+cancer+and+non-cancer+health+outcomes+in+a+cohort+of+US+firefighters+from+San+Francisco%2C+Chicago+and+Philadelphia+%281950-2009%29&rft.au=Daniels%2C+Robert+D%3BBertke%2C+Stephen%3BDahm%2C+Matthew+M%3BYiin%2C+James+H%3BKubale%2C+Travis+L%3BHales%2C+Thomas+R%3BBaris%2C+Dalsu%3BZahm%2C+Shelia+H%3BBeaumont%2C+James+J%3BWaters%2C+Kathleen+M%3BPinkerton%2C+Lynne+E&rft.aulast=Daniels&rft.aufirst=Robert&rft.date=2015-10-11&rft.volume=72&rft.issue=10&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102671 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Leukemia; Mortality; Age; Prostate cancer; Injuries; Dose-response effects; Sampling; Occupational exposure; Lung cancer; Models; Health risks; Firefighter services; Careers; Cancer; USA, Illinois, Chicago; USA, Pennsylvania, Philadelphia; INE, USA, California, San Francisco DO - http://dx.doi.org/10.1136/oemed-2014-102671 ER - TY - JOUR T1 - Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. AN - 1721351482; 26321151 AB - Exposure to the natural pesticide, rotenone, a potent mitochondrial toxin, leads to degeneration in striatal nerve terminals and nigral neurons. Rotenone-induced behavioral, neurochemical and neuropathological changes in rats mimic those observed in Parkinson's disease (PD). Here, protective effects of acetyl-L-carnitine (ALC) in the brain dopaminergic toxicity after a prolonged exposure to rotenone were evaluated using electrophysiological and immunolabeling methods. Adult, male Sprague-Dawley rats were injected i.p. with rotenone alone (1 mg/kg) or rotenone with ALC (either 10 or 100 mg/kg; ALC10 or ALC100, respectively) once daily on days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22, 24, 26, 29, 31, 33 and 37. Control rats received either 100mg/kg ALC or vehicle (30% Solutol HS 15 in 0.9% saline) injections. Animals were weighed on injection days and monitored daily. Motor nerve conduction velocity (MCV) was assessed within two days after treatment using compound muscle action potentials (CMAP) detected from the tail muscle through surface receiver electrodes installed around the distal part of the tail. Rats were perfused immediately after testing with 4% paraformaldehyde and immunohistochemical analysis of dopamine transporter (DAT), tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), and microglial CD11b marker was performed in the caudate-putamen (CPu) and the substantia nigra pars compacta (SNc) in order to estimate dopaminergic neuronal and transporter damage. Additionally, effects of ALC on preventing microglial or astrocytic hypertrophy were also evaluated. In rats exposed to rotenone and rotenone/ACL10, a significant increases in both proximal (S1) and distal (S2) motor latency and a decrease in MCV were detected in tail nerves (p<0.05). The conduction parameters in rats co-treated with rotenone/ACL100 were not different from control. It was found that 100 mg/kg ALC prevented loss of TH and a decline of DAT level in the midbrain and also prevented the activation of both microglia and astroglia after rotenone treatment. Data indicate neuroprotective effects of ALC in rotenone-evoked dopaminergic neurotoxicity. Published by Elsevier Ireland Ltd. JF - Neuroscience letters AU - Sarkar, S AU - Gough, B AU - Raymick, J AU - Beaudoin, M A AU - Ali, S F AU - Virmani, A AU - Binienda, Z K AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research/FDA, Jefferson, AR, USA. ; Innovation, Research and Development Nutraceuticals and Carnitines International Division, Sigma-tau BV and Sigma-tau HealthScience BV, Groenewoudsedijk 55, Postbus 2079, 3500 GB Utrecht, The Netherlands. ; Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. Electronic address: zbigniew.binienda@fda.hhs.gov. Y1 - 2015/10/08/ PY - 2015 DA - 2015 Oct 08 SP - 53 EP - 59 VL - 606 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Glial Fibrillary Acidic Protein KW - Neuroprotective Agents KW - Pesticides KW - Rotenone KW - 03L9OT429T KW - Acetylcarnitine KW - 6DH1W9VH8Q KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Tyrosine hydroxylase KW - Midbrain KW - Peripheral nerves KW - Dopamine transporter (DAT) KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Tail -- innervation KW - Caudate Nucleus -- metabolism KW - Muscle, Skeletal -- innervation KW - Glial Fibrillary Acidic Protein -- metabolism KW - Action Potentials KW - Muscle, Skeletal -- drug effects KW - Substantia Nigra -- metabolism KW - Rats, Sprague-Dawley KW - Tail -- drug effects KW - Neural Conduction KW - Putamen -- metabolism KW - Dopamine Plasma Membrane Transport Proteins -- metabolism KW - Male KW - Microglia -- metabolism KW - Rotenone -- toxicity KW - Dopamine -- metabolism KW - Acetylcarnitine -- pharmacology KW - Pesticides -- toxicity KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1721351482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Histopathological+and+electrophysiological+indices+of+rotenone-evoked+dopaminergic+toxicity%3A+Neuroprotective+effects+of+acetyl-L-carnitine.&rft.au=Sarkar%2C+S%3BGough%2C+B%3BRaymick%2C+J%3BBeaudoin%2C+M+A%3BAli%2C+S+F%3BVirmani%2C+A%3BBinienda%2C+Z+K&rft.aulast=Sarkar&rft.aufirst=S&rft.date=2015-10-08&rft.volume=606&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=1872-7972&rft_id=info:doi/10.1016%2Fj.neulet.2015.08.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-01 N1 - Date created - 2015-10-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neulet.2015.08.044 ER - TY - JOUR T1 - FDA Approval Summary: Olaparib Monotherapy in Patients with Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer Treated with Three or More Lines of Chemotherapy AN - 1808634833; PQ0003449269 AB - On December 19, 2014, the FDA approved olaparib capsules (Lynparza; AstraZeneca) for the treatment of patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy. The BRACAnalysis CDx (Myriad Genetic Laboratories, Inc.) was approved concurrently. An international multicenter, single-arm trial enrolled 137 patients with measurable gBRCAm-associated ovarian cancer treated with three or more prior lines of chemotherapy. Patients received olaparib at a dose of 400 mg by mouth twice daily until disease progression or unacceptable toxicity. The objective response rate (ORR) was 34% with median response duration of 7.9 months in this cohort. The most common adverse reactions ( greater than or equal to 20%) in patients treated with olaparib were anemia, nausea, fatigue (including asthenia), vomiting, diarrhea, dysgeusia, dyspepsia, headache, decreased appetite, nasopharyngitis/pharyngitis/upper respiratory infection, cough, arthralgia/musculoskeletal pain, myalgia, back pain, dermatitis/rash, and abdominal pain/discomfort. Myelodysplatic syndrome and/or acute myeloid leukemia occurred in 2% of the patients enrolled on this trial. Clin Cancer Res; 21(19); 4257-61. copyright 2015 AACR. JF - Clinical Cancer Research AU - Kim, Geoffrey AU - Ison, Gwynn AU - McKee, Amy E AU - Zhang, Hui AU - Tang, Shenghui AU - Gwise, Thomas AU - Sridhara, Rajeshwari AU - Lee, Eunice AU - Tzou, Abraham AU - Philip, Reena AU - Chiu, Haw-Jyh AU - Ricks, Tiffany K AU - Palmby, Todd AU - Russell, Anne Marie AU - Ladouceur, Gaetan AU - Pfuma, Elimika AU - Li, Hongshan AU - Zhao, Liang AU - Liu, Qi AU - Venugopal, Rajesh AU - Ibrahim, Amna AU - Pazdur, Richard AD - Office of Hematology and Oncology Products (OHOP), U.S. Food and Drug Administration, Silver Spring, Maryland, Geoffrey.Kim@fda.hhs.gov Y1 - 2015/10/01/ PY - 2015 DA - 2015 Oct 01 SP - 4257 EP - 4261 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 21 IS - 19 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Ovarian cancer KW - Diarrhea KW - Vomiting KW - Acute myeloid leukemia KW - Asthenia KW - Chemotherapy KW - Anemia KW - Cough KW - Pain KW - Toxicity KW - Pharyngitis KW - Infection KW - Clinical trials KW - Exanthema KW - Headache KW - Nausea KW - Mouth KW - Myalgia KW - Dermatitis KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808634833?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=FDA+Approval+Summary%3A+Olaparib+Monotherapy+in+Patients+with+Deleterious+Germline+BRCA-Mutated+Advanced+Ovarian+Cancer+Treated+with+Three+or+More+Lines+of+Chemotherapy&rft.au=Kim%2C+Geoffrey%3BIson%2C+Gwynn%3BMcKee%2C+Amy+E%3BZhang%2C+Hui%3BTang%2C+Shenghui%3BGwise%2C+Thomas%3BSridhara%2C+Rajeshwari%3BLee%2C+Eunice%3BTzou%2C+Abraham%3BPhilip%2C+Reena%3BChiu%2C+Haw-Jyh%3BRicks%2C+Tiffany+K%3BPalmby%2C+Todd%3BRussell%2C+Anne+Marie%3BLadouceur%2C+Gaetan%3BPfuma%2C+Elimika%3BLi%2C+Hongshan%3BZhao%2C+Liang%3BLiu%2C+Qi%3BVenugopal%2C+Rajesh%3BIbrahim%2C+Amna%3BPazdur%2C+Richard&rft.aulast=Kim&rft.aufirst=Geoffrey&rft.date=2015-10-01&rft.volume=21&rft.issue=19&rft.spage=4257&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-0887 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Vomiting; Diarrhea; Asthenia; Acute myeloid leukemia; Chemotherapy; Anemia; Cough; Pain; Pharyngitis; Toxicity; Infection; Clinical trials; Exanthema; Headache; Nausea; Mouth; Myalgia; Dermatitis DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-0887 ER - TY - JOUR T1 - Measurement of impulse peak insertion loss from two acoustic test fixtures and four hearing protector conditions with an acoustic shock tube AN - 1790940494; PQ0003070589 AB - Impulse peak insertion loss (IPIL) was studied with two acoustic test fixtures and four hearing protector conditions at the E-A-RCAL Laboratory. IPIL is the difference between the maximum estimated pressure for the open-ear condition and the maximum pressure measured when a hearing protector is placed on an acoustic test fixture (ATF). Two models of an ATF manufactured by the French-German Research Institute of Saint-Louis (ISL) were evaluated with high-level acoustic impulses created by an acoustic shock tube at levels of 134 decibels (dB), 150 dB, and 168 dB. The fixtures were identical except that the E-A-RCAL ISL fixture had ear canals that were 3 mm longer than the National Institute for Occupational Safety and Health (NIOSH) ISL fixture. Four hearing protection conditions were tested: Combat Arms earplug with the valve open, ETY(R) Plugs earplug, TacticalPro headset, and a dual-protector ETYPlugs earplug with TacticalPro earmuff. The IPILs measured for the E-A-RCAL fixture were 1.4 dB greater than the National Institute for Occupational Safety and Health (NIOSH) ISL ATF. For the E-A-RCAL ISL ATF, the left ear IPIL was 2.0 dB greater than the right ear IPIL. For the NIOSH ATF, the right ear IPIL was 0.3 dB greater than the left ear IPIL. JF - Noise and Health AU - Murphy, William J AU - Fackler, Cameron J AU - Berger, Elliott H AU - Shaw, Peter B AU - Stergar, Mike AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 364 EP - 373 PB - University College London, 330 Gray's Inn Road London WC1X 8EE United Kingdom VL - 17 IS - 78 SN - 1463-1741, 1463-1741 KW - Health & Safety Science Abstracts KW - Acoustics KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790940494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+and+Health&rft.atitle=Measurement+of+impulse+peak+insertion+loss+from+two+acoustic+test+fixtures+and+four+hearing+protector+conditions+with+an+acoustic+shock+tube&rft.au=Murphy%2C+William+J%3BFackler%2C+Cameron+J%3BBerger%2C+Elliott+H%3BShaw%2C+Peter+B%3BStergar%2C+Mike&rft.aulast=Murphy&rft.aufirst=William&rft.date=2015-10-01&rft.volume=17&rft.issue=78&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=Noise+and+Health&rft.issn=14631741&rft_id=info:doi/10.4103%2F1463-1741.165067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Acoustics; Occupational safety DO - http://dx.doi.org/10.4103/1463-1741.165067 ER - TY - JOUR T1 - Cigarette Smoking Prevalence Among Adults Working in the Health Care and Social Assistance Sector, 2008 to 2012 AN - 1762353836; PQ0002503698 AB - Objective: The primary objective of this study was to estimate current smoking among workers in the health care and social assistance sector. Methods: We analyzed the 2008 to 2012 National Health Interview Survey data for adults (age 18 years or more) working in health care and social assistance sector who reported current cigarette smoking. Results: Of the approximately 18.9 million health care and social assistance workers, 16.0% were current cigarette smokers. Smoking prevalence was highest in women (16.9%) and among workers: age 25 to 44 years (17.7%); with a high school education or less (24.4%); with income less than $35,000 (19.5%); with no health insurance (28.5%); in the nursing and residential care facilities (26.9%) industry; and in the material recording, scheduling, dispatching, and distributing (34.7%) occupations. Conclusions: These findings suggest that specific group of workers in the health care and social assistance sector might particularly benefit from cessation programs and incentives to quit smoking. JF - Journal of Occupational and Environmental Medicine AU - Syamlal, Girija AU - Mazurek, Jacek M AU - Storey, Eileen AU - Dube, Shanta R AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, gsyamlal@cdc.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1107 EP - 1112 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 10 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Age KW - Education KW - Health care KW - Cigarettes KW - Cigarette smoking KW - Incentives KW - Insurance KW - Recording KW - Income KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762353836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Cigarette+Smoking+Prevalence+Among+Adults+Working+in+the+Health+Care+and+Social+Assistance+Sector%2C+2008+to+2012&rft.au=Syamlal%2C+Girija%3BMazurek%2C+Jacek+M%3BStorey%2C+Eileen%3BDube%2C+Shanta+R&rft.aulast=Syamlal&rft.aufirst=Girija&rft.date=2015-10-01&rft.volume=57&rft.issue=10&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000529 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Education; Age; Cigarettes; Health care; Cigarette smoking; Incentives; Insurance; Income; Recording DO - http://dx.doi.org/10.1097/JOM.0000000000000529 ER - TY - JOUR T1 - Analysis of gob gas venthole production performances for strata gas control in longwall mining AN - 1734265421; 2015-109890 AB - Longwall mining of coal seams affects a large area of overburden by deforming it and creating stress-relief fractures, as well as bedding plane separations, as the mining face progresses. Stress-relief fractures and bedding plane separations are recognized as major pathways for gas migration from gas-bearing strata into sealed and active areas of the mines. In order for strata gas not to enter and inundate the ventilation system of a mine, gob gas ventholes (GGVs) can be used as a methane control measure. The aim of this paper is to analyze production performances of GGVs drilled over a longwall panel. These boreholes were drilled to control methane emissions from the Pratt group of coals due to stress-relief fracturing and bedding plane separations into a longwall mine operating in the Mary Lee/Blue Creek coal seam of the Upper Pottsville Formation in the Black Warrior Basin, Alabama. During the course of the study, Pratt coal's reservoir properties were integrated with production data of the GGVs. These data were analyzed by using material balance techniques to estimate radius of influence of GGVs, gas-in-place and coal pressures, as well as their variations during mining. The results show that the GGVs drilled to extract gas from the stress-relief zone of the Pratt coal interval is highly effective in removing gas from the Upper Pottsville Formation. The radii of influence of the GGVs were in the order of 330-380 m, exceeding the widths of the panels, due to bedding plane separations and stress relieved by fracturing. Material balance analyses indicated that the initial pressure of the Pratt coals, which was around 648 KPa when longwall mining started, decreased to approximately 150 KPa as the result of strata fracturing and production of released gas. Approximately 70% of the initial gas-in-place within the area of influence of the GGVs was captured during a period of one year. Abstract Copyright (2015) Elsevier, B.V. JF - International Journal of Rock Mechanics and Mining Sciences (1997) AU - Karacan, C Ozgen Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 9 EP - 18 PB - Elsevier, Oxford-New York VL - 79 SN - 1365-1609, 1365-1609 KW - United States KW - mining KW - geologic hazards KW - underground mining KW - Pennsylvanian KW - aliphatic hydrocarbons KW - coal seams KW - Alabama KW - fractures KW - rock bursts KW - faults KW - methane KW - Paleozoic KW - stress KW - Carboniferous KW - alkanes KW - preventive measures KW - Black Warrior Basin KW - organic compounds KW - Mary Lee Mine KW - safety KW - longwall mining KW - natural hazards KW - hydrocarbons KW - Pottsville Group KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734265421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.atitle=Analysis+of+gob+gas+venthole+production+performances+for+strata+gas+control+in+longwall+mining&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2015-10-01&rft.volume=79&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.issn=13651609&rft_id=info:doi/10.1016%2Fj.ijrmms.2015.08.001 L2 - http://www.sciencedirect.com/science/journal/13651609 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2015-01-01 N1 - Number of references - 34 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2015-11-19 N1 - CODEN - IJRMA2 N1 - SubjectsTermNotLitGenreText - Alabama; aliphatic hydrocarbons; alkanes; Black Warrior Basin; Carboniferous; coal seams; faults; fractures; geologic hazards; hydrocarbons; longwall mining; Mary Lee Mine; methane; mining; natural hazards; organic compounds; Paleozoic; Pennsylvanian; Pottsville Group; preventive measures; rock bursts; safety; stress; underground mining; United States DO - http://dx.doi.org/10.1016/j.ijrmms.2015.08.001 ER - TY - RPRT T1 - FOREWORD AN - 1732067520 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732067520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-10-01&rft.volume=&rft.issue=583&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2015 N1 - Last updated - 2015-11-10 ER - TY - RPRT T1 - Table of contents AN - 1732067519 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732067519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-10-01&rft.volume=&rft.issue=583&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2015 N1 - Last updated - 2015-11-10 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF BROMODICHLOROACETIC ACID (CAS NO. 71133-14-7) IN F344/N RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF BROMODICHLOROACETIC ACID IN F344/NTac RATS AND B6C3F1/N MICE (DRINKING WATER STUDIES) AN - 1732067458 AB - Bromodichloroacetic acid occurs as a by-product of water disinfection. We studied the effects of bromodichloroacetic acid in drinking water on male and female rats and mice to identity potential toxic or cancer-related hazards. We gave drinking water containing 250, 500 or 1,000 mg of bromodichloroacetic acid per liter of water to groups of 50 male and female rats and mice for two years. Control animals received the same tap water with no chemical added. At the end of the study tissues from more than 40 sites were examined for every animal. Groups of female rats and male mice receiving 500 or 1,000 mg/L of bromodichloroacetic acid had lower survival rates than the control groups. Male rats receiving bromodichloroacetic acid had increased rates of malignant mesotheliomas and a variety of skin tumors. Exposed female rats had increased incidences of fibroadenomas and carcinomas of the mammary gland. There were a few occurrences of uncommon tumors of the oral cavity, large intestine, and mammary gland in male rats exposed to bromodichloroacetic acid and of uncommon brain tumors in exposed male and female rats. Incidences of malignant liver tumors (hepatocellular carcinomas and hepatoblastomas) were seen in male and female mice exposed to bromodichloroacetic acid. Exposed male mice had increased incidences of adenomas and carcinomas of the Harderian gland. We conclude that bromodichloroacetic acid in the drinking water caused malignant mesothelioma and skin tumors in male rats and fibroadenomas and carcinomas of the mammary gland in female rats. Brain tumors in male and female rats and tumors of the oral cavity, large intestine, and mammary gland in male rats may also have been related to bromodichloroacetic acid exposure. We conclude that bromodichloroacetic acid caused liver cancer in male and female mice and Harderian gland cancer in male mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 1 EP - 131,133-161,163-177,179-181,183-189,191-193,195-209,211-215,217-231,233-258 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Toxicology KW - Rodents KW - Acids KW - Drinking water KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732067458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+BROMODICHLOROACETIC+ACID+%28CAS+NO.+71133-14-7%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+BROMODICHLOROACETIC+ACID+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-10-01&rft.volume=&rft.issue=583&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2015 N1 - Document feature - Tables; Graphs; Photographs; References N1 - Last updated - 2015-11-10 ER - TY - JOUR T1 - Ultrafine and respirable particle exposure during vehicle fire suppression AN - 1727690752; PQ0002120240 AB - Vehicle fires are a common occurrence, yet few studies have reported exposures associated with burning vehicles. This article presents an assessment of firefighters' potential for ultrafine and respirable particle exposure during vehicle fire suppression training. Fires were initiated within the engine compartment and passenger cabins of three salvaged vehicles, with subsequent water suppression by fire crews. Firefighter exposures were monitored with an array of direct reading particle and air quality instruments. A flexible metallic duct and blower drew contaminants to the instrument array, positioned at a safe distance from the burning vehicles, with the duct inlet positioned at the nozzle operator's shoulder. The instruments measured the particle number, active surface area, respirable particle mass, photoelectric response, aerodynamic particle size distributions, and air quality parameters. Although vehicle fires were suppressed quickly (<10 minutes), firefighters may be exposed to short duration, high particle concentration episodes during fire suppression, which are orders of magnitude greater than the ambient background concentration. A maximum transient particle concentration of 1.21 10 super(7) particles per cm super(3), 170 mg m super(-3) respirable particle mass, 4700 mu m super(2) cm super(-3) active surface area and 1400 (arbitrary units) in photoelectric response were attained throughout the series of six fires. Expressed as fifteen minute time-weighted averages, engine compartment fires averaged 5.4 10 super(4) particles per cm super(3), 0.36 mg m super(-3) respirable particle mass, 92 mu m super(2) cm super(-3) active particle surface area and 29 (arbitrary units) in photoelectric response. Similarly, passenger cabin fires averaged 2.04 10 super(5) particles per cm super(3), 2.7 mg m super(-3) respirable particle mass, 320 mu m super(2) cm super(-3) active particle surface area, and 34 (arbitrary units) in photoelectric response. Passenger cabin fires were a greater potential source of exposure than engine compartment fires. The wind direction and the relative position of the fire crew to the stationary burning vehicle played a primary role in fire crews' potential for exposure. We recommend that firefighters wear self-contained breathing apparatus during all phases of the vehicle fire response to significantly reduce their potential for particulate, vapor, and gaseous exposures. JF - Environmental Sciences: Processes and Impacts AU - Evans, Douglas E AU - Fent, Kenneth W AD - Chemical Exposure and Monitoring Branch; Division of Applied Research and Technology; National Institute for Occupational Safety and Health; Centers for Disease Control and Prevention; 1090 Tusculum Avenue, MS R-7; Cincinnati; Ohio; USA; +1 513 841 4545; +1 513 841 4407; , dje3@cdc.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1749 EP - 1759 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 17 IS - 10 SN - 2050-7887, 2050-7887 KW - Environment Abstracts; Pollution Abstracts KW - Particle size KW - Fires KW - Training KW - Surface area KW - Air quality KW - Particulates KW - Vapors KW - Aerodynamics KW - Firefighter services KW - Burning KW - Wind KW - Wear KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727690752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Sciences%3A+Processes+and+Impacts&rft.atitle=Ultrafine+and+respirable+particle+exposure+during+vehicle+fire+suppression&rft.au=Evans%2C+Douglas+E%3BFent%2C+Kenneth+W&rft.aulast=Evans&rft.aufirst=Douglas&rft.date=2015-10-01&rft.volume=17&rft.issue=10&rft.spage=1749&rft.isbn=&rft.btitle=&rft.title=Environmental+Sciences%3A+Processes+and+Impacts&rft.issn=20507887&rft_id=info:doi/10.1039%2Fc5em00233h LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 44 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Particle size; Fires; Vapors; Training; Aerodynamics; Surface area; Firefighter services; Air quality; Burning; Particulates; Wear; Wind DO - http://dx.doi.org/10.1039/c5em00233h ER - TY - JOUR T1 - WGS accurately predicts antimicrobial resistance in Escherichia coli AN - 1727679884; PQ0002143030 AB - Objectives The objective of this study was to determine the effectiveness of WGS in identifying resistance genotypes of MDR Escherichia coli and whether these correlate with observed phenotypes. Methods Seventy-six E. coli strains were isolated from farm cattle and measured for phenotypic resistance to 15 antimicrobials with the Sensititre super( registered ) system. Isolates with resistance to at least four antimicrobials in three classes were selected for WGS using an Illumina MiSeq. Genotypic analysis was conducted with in-house Perl scripts using BLAST analysis to identify known genes and mutations associated with clinical resistance. Results Over 30 resistance genes and a number of resistance mutations were identified among the E. coli isolates. Resistance genotypes correlated with 97.8% specificity and 99.6% sensitivity to the identified phenotypes. The majority of discordant results were attributable to the aminoglycoside streptomycin, whereas there was a perfect genotype-phenotype correlation for most antibiotic classes such as tetracyclines, quinolones and phenicols. WGS also revealed information about rare resistance mechanisms, such as structural mutations in chromosomal copies of ampC conferring third-generation cephalosporin resistance. Conclusions WGS can provide comprehensive resistance genotypes and is capable of accurately predicting resistance phenotypes, making it a valuable tool for surveillance. Moreover, the data presented here showing the ability to accurately predict resistance suggest that WGS may be used as a screening tool in selecting anti-infective therapy, especially as costs drop and methods improve. JF - Journal of Antimicrobial Chemotherapy AU - Tyson, Gregory H AU - McDermott, Patrick F AU - Li, Cong AU - Chen, Yuansha AU - Tadesse, Daniel A AU - Mukherjee, Sampa AU - Bodeis-Jones, Sonya AU - Kabera, Claudine AU - Gaines, Stuart A AU - Loneragan, Guy H AU - Edrington, Tom S AU - Torrence, Mary AU - Harhay, Dayna M AU - Zhao, Shaohua Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 2763 EP - 2769 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 70 IS - 10 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cephalosporins KW - Data processing KW - Farms KW - Drug resistance KW - Quinolones KW - Antibiotics KW - Genotypes KW - Streptomycin KW - Tetracyclines KW - Aminoglycoside antibiotics KW - Antimicrobial agents KW - Escherichia coli KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727679884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=WGS+accurately+predicts+antimicrobial+resistance+in+Escherichia+coli&rft.au=Tyson%2C+Gregory+H%3BMcDermott%2C+Patrick+F%3BLi%2C+Cong%3BChen%2C+Yuansha%3BTadesse%2C+Daniel+A%3BMukherjee%2C+Sampa%3BBodeis-Jones%2C+Sonya%3BKabera%2C+Claudine%3BGaines%2C+Stuart+A%3BLoneragan%2C+Guy+H%3BEdrington%2C+Tom+S%3BTorrence%2C+Mary%3BHarhay%2C+Dayna+M%3BZhao%2C+Shaohua&rft.aulast=Tyson&rft.aufirst=Gregory&rft.date=2015-10-01&rft.volume=70&rft.issue=10&rft.spage=2763&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkv186 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Cephalosporins; Farms; Data processing; Drug resistance; Quinolones; Antibiotics; Streptomycin; Genotypes; Tetracyclines; Mutation; Aminoglycoside antibiotics; Antimicrobial agents; Escherichia coli DO - http://dx.doi.org/10.1093/jac/dkv186 ER - TY - JOUR T1 - Maternal occupational pesticide exposure and risk of congenital heart defects in the National Birth Defects Prevention Study. AN - 1722923910; 26033688 AB - Congenital heart defects (CHDs) are common birth defects, affecting approximately 1% of live births. Pesticide exposure has been suggested as an etiologic factor for CHDs, but previous results were inconsistent. We examined maternal occupational exposure to fungicides, insecticides, and herbicides for 3328 infants with CHDs and 2988 unaffected control infants of employed mothers using data for 1997 through 2002 births from the National Birth Defects Prevention Study, a population-based multisite case-control study. Potential pesticide exposure from 1 month before conception through the first trimester of pregnancy was assigned by an expert-guided task-exposure matrix and job history details self-reported by mothers. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression. Maternal occupational exposure to pesticides was not associated with CHDs overall. In examining specific CHD subtypes compared with controls, some novel associations were observed with higher estimated pesticide exposure: insecticides only and secundum atrial septal defect (OR = 1.8; 95% CI, 1.3-2.7, 40 exposed cases); both insecticides and herbicides and hypoplastic left heart syndrome (OR = 5.1; 95% CI, 1.7-15.3, 4 exposed cases), as well as pulmonary valve stenosis (OR = 3.6; 95% CI, 1.3-10.1, 5 exposed cases); and insecticides, herbicides, and fungicides and tetralogy of Fallot (TOF) (OR = 2.2; 95% CI, 1.2-4.0, 13 exposed cases). Broad pesticide exposure categories were not associated with CHDs overall, but examining specific CHD subtypes revealed some increased odds ratios. These results highlight the importance of examining specific CHDs separately. Because of multiple comparisons, additional work is needed to verify these associations. © 2014 Wiley Periodicals, Inc. JF - Birth defects research. Part A, Clinical and molecular teratology AU - Rocheleau, Carissa M AU - Bertke, Stephen J AU - Lawson, Christina C AU - Romitti, Paul A AU - Sanderson, Wayne T AU - Malik, Sadia AU - Lupo, Philip J AU - Desrosiers, Tania A AU - Bell, Erin AU - Druschel, Charlotte AU - Correa, Adolfo AU - Reefhuis, Jennita AU - National Birth Defects Prevention Study AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio. ; Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa. ; Department of Epidemiology, University of Kentucky, Lexington, Kentucky. ; University of Arkansas for Medical Sciences, Little Rock, Arkansas. ; Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, Texas. ; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina. ; Department of Epidemiology and Biostatistics, School of Public Health, State University of New York at Albany, Rensselaer, New York. ; Departments of Medicine and Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi. ; Centers for Disease Control and Prevention, National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia. ; National Birth Defects Prevention Study Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 823 EP - 833 VL - 103 IS - 10 KW - Pesticides KW - 0 KW - Index Medicus KW - occupation KW - birth defects KW - pesticides KW - congenital heart defects KW - United States KW - Risk Factors KW - Humans KW - Adult KW - Retrospective Studies KW - Female KW - Pregnancy KW - Maternal Exposure -- adverse effects KW - Heart Defects, Congenital -- epidemiology KW - Occupational Exposure -- adverse effects KW - Pesticides -- adverse effects KW - Heart Defects, Congenital -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722923910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.atitle=Maternal+occupational+pesticide+exposure+and+risk+of+congenital+heart+defects+in+the+National+Birth+Defects+Prevention+Study.&rft.au=Rocheleau%2C+Carissa+M%3BBertke%2C+Stephen+J%3BLawson%2C+Christina+C%3BRomitti%2C+Paul+A%3BSanderson%2C+Wayne+T%3BMalik%2C+Sadia%3BLupo%2C+Philip+J%3BDesrosiers%2C+Tania+A%3BBell%2C+Erin%3BDruschel%2C+Charlotte%3BCorrea%2C+Adolfo%3BReefhuis%2C+Jennita%3BNational+Birth+Defects+Prevention+Study&rft.aulast=Rocheleau&rft.aufirst=Carissa&rft.date=2015-10-01&rft.volume=103&rft.issue=10&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+A%2C+Clinical+and+molecular+teratology&rft.issn=1542-0760&rft_id=info:doi/10.1002%2Fbdra.23351 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-01 N1 - Date created - 2015-10-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cardiol Clin. 1993 Nov;11(4):557-67 [8252559] Public Health Rep. 2001;116 Suppl 1:32-40 [11889273] Am J Epidemiol. 1999 Jan 1;149(1):64-74 [9883795] Epidemiology. 1999 Jan;10(1):37-48 [9888278] Am J Epidemiol. 2001 Mar 15;153(6):529-36 [11257060] Am J Epidemiol. 2001 Jun 15;153(12):1227-32 [11415959] Epidemiology. 1999 Jan;10(1):60-6 [9888281] Epidemiology. 2007 Sep;18(5):561-8 [17700242] Birth Defects Res A Clin Mol Teratol. 2007 Oct;79(10):714-27 [17729292] Am J Epidemiol. 2008 Apr 15;167(8):976-85 [18299277] Occup Med (Lond). 2001 Jun;51(4):230-44 [11463868] Environ Res. 2014 Nov;135:133-8 [25262086] J Am Coll Cardiol. 2002 Jun 19;39(12):1890-900 [12084585] Occup Environ Med. 2002 Sep;59(9):575-93; discussion 594 [12205230] Birth Defects Res A Clin Mol Teratol. 2003 Mar;67(3):193-201 [12797461] J Occup Environ Med. 2004 Sep;46(9):916-23 [15354055] Arch Environ Health. 1984 Jan-Feb;39(1):56-60 [6712286] Teratology. 1991 Oct;44(4):415-28 [1962287] Int Arch Occup Environ Health. 1992;64(1):59-64 [1399016] Teratology. 1992 Nov;46(5):447-54 [1462249] J Pediatr. 2008 Dec;153(6):807-13 [18657826] Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2010;13(1):26-34 [20307858] Hum Reprod. 2012 May;27(5):1510-7 [22357765] Occup Environ Med. 2012 Sep;69(9):628-35 [22811060] Toxicology. 2013 May 10;307:66-73 [23438386] Am J Ind Med. 1998 Mar;33(3):232-40 [9481421] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdra.23351 ER - TY - JOUR T1 - Direct-acting antiviral drug approvals for treatment of chronic hepatitis C virus infection: Scientific and regulatory approaches to clinical trial designs AN - 1722178463; PQ0002089829 AB - Therapeutic options for treatment of chronic hepatitis C have improved substantially since the approval of direct-acting antiviral agents (DAAs). Several interferon (IFN)-free or IFN- and ribavirin (RBV)-free treatment regimens with shorter durations and improved efficacy and safety profiles are now available. The U.S. Food and Drug Administration (FDA) used several scientific approaches and regulatory mechanisms, such as (1) use of a "validated" surrogate (sustained virological response) for a primary endpoint, (2) shortening the time point for measuring the surrogate by 12 weeks, (3) use of historical controls when clinically appropriate, and (4) use of modeling when scientifically sound to extend treatment indications to subpopulations not fully evaluated in clinical trials, which had an impact on DAA development and subsequent approvals. This article intends to provide increased transparency about the FDA's scientific approaches and regulatory processes that supported drug development and marketing approval of DAAs for treatment of hepatitis C, a serious, life-threatening infection. (Hepatology 2015; 62:1298-1303) JF - Hepatology AU - Mishra, Poonam AU - Murray, Jeffrey AU - Birnkrant, Debra AD - Division of Antiviral Products/Office of Antimicrobial Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1298 EP - 1303 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 4 SN - 0270-9139, 0270-9139 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - Interferon KW - Hepatitis C virus KW - Antiviral agents KW - Subpopulations KW - Ribavirin KW - Chronic infection KW - Drug development KW - Hepatitis C KW - Clinical trials KW - A 01330:Food Microbiology KW - F 06910:Microorganisms & Parasites KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722178463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Pharmacokinetics+of+bisphenol+A+in+humans+following+a+single+oral+administration.&rft.au=Thayer%2C+Kristina+A%3BDoerge%2C+Daniel+R%3BHunt%2C+Dawn%3BSchurman%2C+Shepherd+H%3BTwaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BGarantziotis%2C+Stavros%3BKissling%2C+Grace+E%3BEasterling%2C+Michael+R%3BBucher%2C+John+R%3BBirnbaum%2C+Linda+S&rft.aulast=Thayer&rft.aufirst=Kristina&rft.date=2015-10-01&rft.volume=83&rft.issue=&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2015.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Interferon; Antiviral agents; Subpopulations; Chronic infection; Ribavirin; Drug development; Hepatitis C; Clinical trials; Hepatitis C virus DO - http://dx.doi.org/10.1002/hep.27880 ER - TY - JOUR T1 - MiRNA-Mediated Regulation of the SWI/SNF Chromatin Remodeling Complex Controls Pluripotency and Endodermal Differentiation in Human ESCs AN - 1722177713; PQ0002019745 AB - MicroRNAs and chromatin remodeling complexes represent powerful epigenetic mechanisms that regulate the pluripotent state. miR-302 is a strong inducer of pluripotency, which is characterized by a distinct chromatin architecture. This suggests that miR-302 regulates global chromatin structure; however, a direct relationship between miR-302 and chromatin remodelers has not been established. Here, we provide data to show that miR-302 regulates Brg1 chromatin remodeling complex composition in human embryonic stem cells (hESCs) through direct repression of the BAF53a and BAF170 subunits. With the subsequent overexpression of BAF170 in hESCs, we show that miR-302's inhibition of BAF170 protein levels can affect the expression of genes involved in cell proliferation. Furthermore, miR-302-mediated repression of BAF170 regulates pluripotency by positively influencing mesendodermal differentiation. Overexpression of BAF170 in hESCs led to biased differentiation toward the ectoderm lineage during EB formation and severely hindered directed definitive endoderm differentiation. Taken together, these data uncover a direct regulatory relationship between miR-302 and the Brg1 chromatin remodeling complex that controls gene expression and cell fate decisions in hESCs and suggests that similar mechanisms are at play during early human development. Stem Cells 2015; 33:2925-2935 JF - Stem Cells AU - Wade, Staton L AU - Langer, Lee F AU - Ward, James M AU - Archer, Trevor K AD - Chromatin and Gene Expression Group, Epigenetics and Stem Cell Biology Laboratory, Department of Health and Human Services. Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 2925 EP - 2935 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 33 IS - 10 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Play KW - Data processing KW - Chromatin remodeling KW - Ectoderm KW - miRNA KW - Differentiation KW - Stem cells KW - Embryo cells KW - epigenetics KW - Endoderm KW - Cell fate KW - Cell proliferation KW - BRG1 protein KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722177713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=MiRNA-Mediated+Regulation+of+the+SWI%2FSNF+Chromatin+Remodeling+Complex+Controls+Pluripotency+and+Endodermal+Differentiation+in+Human+ESCs&rft.au=Wade%2C+Staton+L%3BLanger%2C+Lee+F%3BWard%2C+James+M%3BArcher%2C+Trevor+K&rft.aulast=Wade&rft.aufirst=Staton&rft.date=2015-10-01&rft.volume=33&rft.issue=10&rft.spage=2925&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/10.1002%2Fstem.2084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Data processing; Play; Chromatin remodeling; Ectoderm; miRNA; Differentiation; Stem cells; Embryo cells; epigenetics; Endoderm; Cell fate; Cell proliferation; BRG1 protein DO - http://dx.doi.org/10.1002/stem.2084 ER - TY - JOUR T1 - Scientific and Regulatory Policy Committee Review: Review of the Organisation for Economic Co-operation and Development (OECD) Guidance on the GLP Requirements for Peer Review of Histopathology. AN - 1718906893; 26208968 AB - In 2014, the Organisation for Economic Co-operation and Development (OECD) issued guidance no. 16, Guidance on the GLP Requirements for Peer Review of Histopathology. The stated purpose of the guidance document is "to provide guidance to pathologists, test facility management, study directors and quality assurance personnel on how the peer review of histopathology should be planned, managed, documented, and reported in order to meet Good Laboratory Practice (GLP) expectations and requirements." On behalf of and in collaboration with the global societies of toxicologic pathology, the Society of Toxicologic Pathology initiated a review of OECD guidance no. 16. The objectives of this review are to provide a unified interpretation of the guidance, to recommend compliant processes for organizations to implement, and to avoid inconsistent process adaptations across the industry. This review of the guidance document is the product of a global collaboration with other societies of toxicologic pathology and provides a section-by-section international consensus view and interpretation of the OECD guidance on peer review. © 2015 by The Author(s). JF - Toxicologic pathology AU - Fikes, James D AU - Patrick, Daniel J AU - Francke, Sabine AU - Frazier, Kendall S AU - Reindel, James F AU - Romeike, Annette AU - Spaet, Robert H AU - Tomlinson, Lindsay AU - Schafer, Kenneth A AU - Socity of Toxicologic Pathology AD - Biogen, Cambridge, Massachusetts, USA Both James D. Fikes and Daniel J. Patrick contributed equally to this article. jim.fikes@biogen.com. ; MPI Research, Mattawan, Michigan, USA Both James D. Fikes and Daniel J. Patrick contributed equally to this article. ; US Food and Drug Administration, College Park, Maryland, USA. ; GlaxoSmithKline, King of Prussia, Pennsylvania, USA. ; Amgen Inc., Seattle, Washington, USA. ; Covance Laboratories, Porcheville, France. ; RSPathologics, Granby, Colorado, USA. ; Pfizer Inc., Andover, Massachusetts, USA. ; Vet Path Services, Inc., Mason, Ohio, USA. ; Socity of Toxicologic Pathology Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 907 EP - 914 VL - 43 IS - 7 KW - Index Medicus KW - guidance KW - GLP KW - regulatory KW - peer review KW - pathology KW - OECD KW - histopathology KW - Animals KW - Humans KW - Organisation for Economic Co-Operation and Development KW - Peer Review -- standards KW - Toxicology -- standards KW - Pathology, Clinical -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718906893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Scientific+and+Regulatory+Policy+Committee+Review%3A+Review+of+the+Organisation+for+Economic+Co-operation+and+Development+%28OECD%29+Guidance+on+the+GLP+Requirements+for+Peer+Review+of+Histopathology.&rft.au=Fikes%2C+James+D%3BPatrick%2C+Daniel+J%3BFrancke%2C+Sabine%3BFrazier%2C+Kendall+S%3BReindel%2C+James+F%3BRomeike%2C+Annette%3BSpaet%2C+Robert+H%3BTomlinson%2C+Lindsay%3BSchafer%2C+Kenneth+A%3BSocity+of+Toxicologic+Pathology&rft.aulast=Fikes&rft.aufirst=James&rft.date=2015-10-01&rft.volume=43&rft.issue=7&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623315596382 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-21 N1 - Date created - 2015-10-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623315596382 ER - TY - JOUR T1 - Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women's Health Study. AN - 1718904299; 25748391 AB - The association between benzene exposure and non-Hodgkin lymphoma (NHL) has been the subject of debate as a result of inconsistent epidemiologic evidence. An International Agency for Research on Cancer (IARC) working group evaluated benzene in 2009 and noted evidence for a positive association between benzene exposure and NHL risk. We evaluated the association between occupational benzene exposure and NHL among 73,087 women enrolled in the prospective population-based Shanghai Women's Health Study. Benzene exposure estimates were derived using a previously developed exposure assessment framework that combined ordinal job-exposure matrix intensity ratings with quantitative benzene exposure measurements from an inspection database of Shanghai factories collected between 1954 and 2000. Associations between benzene exposure metrics and NHL (n = 102 cases) were assessed using Cox proportional hazard models, with study follow-up occurring from December 1996 through December 2009. Women ever exposed to benzene had a significantly higher risk of NHL [hazard ratio (HR) = 1.87, 95% CI: 1.19, 2.96]. Compared with unexposed women, significant trends in NHL risk were observed for increasing years of benzene exposure (p(trend) = 0.006) and increasing cumulative exposure levels (p(trend) = 0.005), with the highest duration and cumulative exposure tertiles having a significantly higher association with NHL (HR = 2.07, 95% CI: 1.07, 4.01 and HR = 2.16, 95% CI: 1.17, 3.98, respectively). Our findings, using a population-based prospective cohort of women with diverse occupational histories, provide additional evidence that occupational exposure to benzene is associated with NHL risk. JF - Environmental health perspectives AU - Bassig, Bryan A AU - Friesen, Melissa C AU - Vermeulen, Roel AU - Shu, Xiao-Ou AU - Purdue, Mark P AU - Stewart, Patricia A AU - Xiang, Yong-Bing AU - Chow, Wong-Ho AU - Zheng, Tongzhang AU - Ji, Bu-Tian AU - Yang, Gong AU - Linet, Martha S AU - Hu, Wei AU - Zhang, Heping AU - Zheng, Wei AU - Gao, Yu-Tang AU - Rothman, Nathaniel AU - Lan, Qing AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 971 EP - 977 VL - 123 IS - 10 KW - Benzene KW - J64922108F KW - Index Medicus KW - Prospective Studies KW - Women's Health KW - Humans KW - China -- epidemiology KW - Adult KW - Aged KW - Middle Aged KW - Female KW - Risk Assessment KW - Occupational Exposure KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Benzene -- analysis KW - Occupational Diseases -- epidemiology KW - Lymphoma, Non-Hodgkin -- chemically induced KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718904299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Occupational+Exposure+to+Benzene+and+Non-Hodgkin+Lymphoma+in+a+Population-Based+Cohort%3A+The+Shanghai+Women%27s+Health+Study.&rft.au=Bassig%2C+Bryan+A%3BFriesen%2C+Melissa+C%3BVermeulen%2C+Roel%3BShu%2C+Xiao-Ou%3BPurdue%2C+Mark+P%3BStewart%2C+Patricia+A%3BXiang%2C+Yong-Bing%3BChow%2C+Wong-Ho%3BZheng%2C+Tongzhang%3BJi%2C+Bu-Tian%3BYang%2C+Gong%3BLinet%2C+Martha+S%3BHu%2C+Wei%3BZhang%2C+Heping%3BZheng%2C+Wei%3BGao%2C+Yu-Tang%3BRothman%2C+Nathaniel%3BLan%2C+Qing&rft.aulast=Bassig&rft.aufirst=Bryan&rft.date=2015-10-01&rft.volume=123&rft.issue=10&rft.spage=971&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408307 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-13 N1 - Date created - 2015-10-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):405-8 [17337643] Occup Environ Med. 2003 Sep;60(9):676-9 [12937190] Environ Mol Mutagen. 2007 Jul;48(6):467-74 [17584886] Environ Mol Mutagen. 2008 Jul;49(6):453-7 [18481315] Am J Ind Med. 2008 Nov;51(11):803-11 [18651579] Epidemiology. 2003 Sep;14(5):569-77 [14501272] Int J Occup Environ Health. 2004 Jan-Mar;10(1):13-21 [15070021] Am J Ind Med. 1996 Mar;29(3):236-46 [8833776] Occup Environ Med. 1996 Nov;53(11):773-81 [9038803] J Natl Cancer Inst. 1997 Jul 16;89(14):1065-71 [9230889] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Am J Epidemiol. 2005 Dec 1;162(11):1123-31 [16236996] Lifetime Data Anal. 2007 Jun;13(2):261-72 [17401682] Blood. 2008 Nov 15;112(10):4247-9 [18711000] Toxicol Ind Health. 2008 Jun-Jul;24(5-6):263-398 [19022880] Blood. 2008 Dec 15;112(13):5150-60 [18796628] Am J Epidemiol. 2009 Jan 15;169(2):176-85 [19056833] Toxicol Sci. 2009 Aug;110(2):293-306 [19478238] J Occup Environ Hyg. 2009 Nov;6(11):659-70 [19753498] Lancet Oncol. 2009 Dec;10(12):1143-4 [19998521] Chem Biol Interact. 2010 Mar 19;184(1-2):129-46 [19900422] Occup Environ Med. 2010 May;67(5):341-7 [20447988] Blood. 2010 Nov 18;116(20):e90-8 [20699439] Environ Health Perspect. 2011 Feb;119(2):159-67 [20880796] Ann Occup Hyg. 2012 Jan;56(1):80-91 [21976309] Cancer Res. 2012 Sep 15;72(18):4733-43 [22846913] J Natl Cancer Inst. 2012 Nov 21;104(22):1724-37 [23111193] Blood. 2013 Aug 8;122(6):951-7 [23814017] Cancer Causes Control. 2001 Apr;12(3):201-12 [11405325] Crit Rev Toxicol. 2002 Jan;32(1):1-42 [11846214] Am J Ind Med. 2002 Oct;42(4):275-85 [12271475] Epidemiology. 2006 Sep;17(5):552-61 [16878041] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408307 ER - TY - JOUR T1 - On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: An update. AN - 1717472890; 26122973 AB - Therapeutic approaches based on isolated compounds obtained from natural products to handle central and peripheral disorders involving oxidative stress and inflammation are more common nowadays. The validation of nutraceutics vs. pharmaceutics as tools to induce preventive and protective profiles in human health alterations is still far of complete acceptance, but the basis to start more solid experimental and clinical protocols with natural products has already begun. S-allyl cysteine (SAC) is a promising garlic-derived organosulfur compound exhibiting a considerable number of positive actions in cell models and living systems. An update, in the form of review, is needed from time to time to get access to the state-of-the-art on this topic. In this review we visited recent and refreshing evidence of new already proven and potential targets to explain the benefits of using SAC against toxic and pathological conditions. The broad spectrum of protective actions covered by this molecule comprises antioxidant, redox modulatory and anti-inflammatory activities, accompanied by anti-apoptotic, pro-energetic and signaling capacities. Herein, we detail the evidence on these aspects to provide the reader a more complete overview on the promising aspects of SAC in research. Published by Elsevier Ltd. JF - Neurochemistry international AU - Colín-González, Ana Laura AU - Ali, Syed F AU - Túnez, Isaac AU - Santamaría, Abel AD - Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, SSA, Mexico City, Mexico. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. Electronic address: Syed.ali@fda.hhs.gov. ; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofia/Universidad de Córdoba, Cordoba, Spain; Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Spain. ; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, SSA, Mexico City, Mexico. Electronic address: absada@yahoo.com. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 83 EP - 91 VL - 89 KW - Advanced Glycosylation End Product-Specific Receptor KW - 0 KW - Anti-Inflammatory Agents KW - Antioxidants KW - Neuroprotective Agents KW - S-allylcysteine KW - 81R3X99M15 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Garlic-derived organosulfur compounds KW - Oxidative stress KW - S-allyl cysteine KW - Neuroprotection KW - Neuroinflammation KW - Animals KW - Oxidation-Reduction -- drug effects KW - Humans KW - Advanced Glycosylation End Product-Specific Receptor -- metabolism KW - Cysteine -- metabolism KW - Cysteine -- analogs & derivatives KW - Neuroprotective Agents -- pharmacology KW - Anti-Inflammatory Agents -- metabolism KW - Cysteine -- pharmacology KW - Neuroprotective Agents -- chemistry KW - Antioxidants -- metabolism KW - Cysteine -- chemistry KW - Anti-Inflammatory Agents -- chemistry KW - Antioxidants -- pharmacology KW - Neuroprotective Agents -- metabolism KW - Antioxidants -- chemistry KW - Garlic KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717472890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=On+the+antioxidant%2C+neuroprotective+and+anti-inflammatory+properties+of+S-allyl+cysteine%3A+An+update.&rft.au=Col%C3%ADn-Gonz%C3%A1lez%2C+Ana+Laura%3BAli%2C+Syed+F%3BT%C3%BAnez%2C+Isaac%3BSantamar%C3%ADa%2C+Abel&rft.aulast=Col%C3%ADn-Gonz%C3%A1lez&rft.aufirst=Ana&rft.date=2015-10-01&rft.volume=89&rft.issue=&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=1872-9754&rft_id=info:doi/10.1016%2Fj.neuint.2015.06.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-04 N1 - Date created - 2015-09-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuint.2015.06.011 ER - TY - JOUR T1 - UVA photoirradiation of benzo[a]pyrene metabolites: induction of cytotoxicity, reactive oxygen species, and lipid peroxidation. AN - 1716937869; 23552265 AB - Benzo[a]pyrene (BaP) is a prototype for studying carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). We have long been interested in studying the phototoxicity of PAHs. In this study, we determined that metabolism of BaP by human skin HaCaT keratinocytes resulted in six identified phase I metabolites, for example, BaP trans-7,8-dihydrodiol (BaP t-7,8-diol), BaP t-4,5-diol, BaP t-9,10-diol, 3-hydroxybenzo[a]pyrene (3-OH-BaP), BaP (7,10/8,9)tetrol, and BaP (7/8,9,10)tetrol. The photocytotoxicity of BaP, 3-OH-BaP, BaP t-7,8-diol, BaP trans-7,8-diol-anti-9,10-epoxide (BPDE), and BaP (7,10/8,9)tetrol in the HaCaT keratinocytes was examined. When irradiated with 1.0 J/cm(2) UVA light, these compounds when tested at doses of 0.1, 0.2, and 0.5 μM, all induced photocytotoxicity in a dose-dependent manner. When photoirradiation was conducted in the presence of a lipid (methyl linoleate), BaP metabolites, BPDE, and three related PAHs, pyrene, 7,8,9,10-tetrahydro-BaP trans-7,8-diol, and 7,8,9,10-tetrahydro-BaP trans-9,10-diol, all induced lipid peroxidation. The formation of lipid peroxides by BaP t-7,8-diol was inhibited by NaN3 and enhanced by deuterated methanol, which suggests that singlet oxygen may be involved in the generation of lipid peroxides. The formation of lipid hydroperoxides was partially inhibited by superoxide dismutase (SOD). Electron spin resonance spin trapping experiments indicated that both singlet oxygen and superoxide radical anion were generated from UVA photoirradiation of BPDE in a light dose responding manner. © The Author(s) 2013. JF - Toxicology and industrial health AU - Xia, Qingsu AU - Chiang, Hsiu-Mei AU - Yin, Jun-Jie AU - Chen, Shoujun AU - Cai, Lining AU - Yu, Hongtao AU - Fu, Peter P AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA Department of Cosmecutics, China Medical University, Taichung, Taiwan, Republic of China. ; Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, USA. ; Biotranex LLC, Monmouth Junction, NJ, USA. ; Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA peter.fu@fda.hhs.gov. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 898 EP - 910 VL - 31 IS - 10 KW - Reactive Oxygen Species KW - 0 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Index Medicus KW - Benzo[a]pyrene KW - Polycyclic aromatic hydrocarbons (PAHs) KW - metabolite KW - reactive oxygen species (ROS) KW - lipid peroxidation KW - Ultraviolet Rays KW - Cells, Cultured KW - Humans KW - Reactive Oxygen Species -- metabolism KW - Cell Survival -- drug effects KW - Keratinocytes -- drug effects KW - Benzo(a)pyrene -- toxicity KW - Lipid Peroxidation -- drug effects KW - Benzo(a)pyrene -- chemistry KW - Benzo(a)pyrene -- radiation effects KW - Benzo(a)pyrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1716937869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=UVA+photoirradiation+of+benzo%5Ba%5Dpyrene+metabolites%3A+induction+of+cytotoxicity%2C+reactive+oxygen+species%2C+and+lipid+peroxidation.&rft.au=Xia%2C+Qingsu%3BChiang%2C+Hsiu-Mei%3BYin%2C+Jun-Jie%3BChen%2C+Shoujun%3BCai%2C+Lining%3BYu%2C+Hongtao%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2015-10-01&rft.volume=31&rft.issue=10&rft.spage=898&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=1477-0393&rft_id=info:doi/10.1177%2F0748233713484648 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-14 N1 - Date created - 2015-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0748233713484648 ER - TY - JOUR T1 - Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage. AN - 1716937524; 26206149 AB - Sevoflurane is a volatile anesthetic that has been widely used in general anesthesia, yet its safety in pediatric use is a public concern. This study sought to evaluate whether prolonged exposure of infant monkeys to a clinically relevant concentration of sevoflurane is associated with any adverse effects on the developing brain. Infant monkeys were exposed to 2.5% sevoflurane for 9 h, and frontal cortical tissues were harvested for DNA microarray, lipidomics, Luminex protein, and histological assays. DNA microarray analysis showed that sevoflurane exposure resulted in a broad identification of differentially expressed genes (DEGs) in the monkey brain. In general, these genes were associated with nervous system development, function, and neural cell viability. Notably, a number of DEGs were closely related to lipid metabolism. Lipidomic analysis demonstrated that critical lipid components, (eg, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol) were significantly downregulated by prolonged exposure of sevoflurane. Luminex protein analysis indicated abnormal levels of cytokines in sevoflurane-exposed brains. Consistently, Fluoro-Jade C staining revealed more degenerating neurons after sevoflurane exposure. These data demonstrate that a clinically relevant concentration of sevoflurane (2.5%) is capable of inducing and maintaining an effective surgical plane of anesthesia in the developing nonhuman primate and that a prolonged exposure of 9 h resulted in profound changes in gene expression, cytokine levels, lipid metabolism, and subsequently, neuronal damage. Generally, sevoflurane-induced neuronal damage was also associated with changes in lipid content, composition, or both; and specific lipid changes could provide insights into the molecular mechanism(s) underlying anesthetic-induced neurotoxicity and may be sensitive biomarkers for the early detection of anesthetic-induced neuronal damage. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by a US Government employee and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Liu, Fang AU - Rainosek, Shuo W AU - Frisch-Daiello, Jessica L AU - Patterson, Tucker A AU - Paule, Merle G AU - Slikker, William AU - Wang, Cheng AU - Han, Xianlin AD - *Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079; Fang.liu@fda.hhs.gov. ; Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205; ; Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL 32827; and. ; *Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079; ; Office of the Director, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 562 EP - 572 VL - 147 IS - 2 KW - Anesthetics, Inhalation KW - 0 KW - Methyl Ethers KW - sevoflurane KW - 38LVP0K73A KW - Index Medicus KW - cytokines KW - development KW - neuronal degeneration KW - lipid metabolism KW - Animals, Newborn KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Brain Chemistry -- drug effects KW - Macaca mulatta KW - Male KW - Female KW - Inhalation Exposure -- adverse effects KW - Methyl Ethers -- adverse effects KW - Anesthetics, Inhalation -- adverse effects KW - Methyl Ethers -- administration & dosage KW - Lipid Metabolism -- drug effects KW - Neurons -- drug effects KW - Brain -- drug effects KW - Brain -- metabolism KW - Anesthetics, Inhalation -- administration & dosage KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1716937524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Potential+Adverse+Effects+of+Prolonged+Sevoflurane+Exposure+on+Developing+Monkey+Brain%3A+From+Abnormal+Lipid+Metabolism+to+Neuronal+Damage.&rft.au=Liu%2C+Fang%3BRainosek%2C+Shuo+W%3BFrisch-Daiello%2C+Jessica+L%3BPatterson%2C+Tucker+A%3BPaule%2C+Merle+G%3BSlikker%2C+William%3BWang%2C+Cheng%3BHan%2C+Xianlin&rft.aulast=Liu&rft.aufirst=Fang&rft.date=2015-10-01&rft.volume=147&rft.issue=2&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv150 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-19 N1 - Date created - 2015-09-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neuroscience. 2000;97(3):591-600 [10828541] Neurosci Biobehav Rev. 2013 Mar;37(3):436-47 [23370232] J Biol Chem. 2000 Nov 10;275(45):35215-23 [10903316] J Immunol. 2001 Feb 1;166(3):1790-5 [11160225] J Neurochem. 2001 May;77(4):1168-80 [11359882] Neurosci Lett. 2001 Sep 28;311(2):105-8 [11567789] Genes Dev. 2001 Nov 15;15(22):2922-33 [11711427] Neurobiol Aging. 2002 Jul-Aug;23(4):547-53 [12009504] J Neurosci. 2003 Feb 1;23(3):876-82 [12574416] J Neurochem. 2003 Mar;84(5):997-1005 [12603824] J Lipid Res. 2003 Jun;44(6):1071-9 [12671038] Mass Spectrom Rev. 2003 Sep-Oct;22(5):332-64 [12949918] Toxicol Sci. 2004 Oct;81(2):364-70 [15254342] J Lipid Res. 1965 Oct;6(4):537-44 [5865382] Biochim Biophys Acta. 1971 Dec 3;249(2):462-92 [5134192] Science. 1992 Dec 18;258(5090):1946-9 [1470919] Glia. 1993 Jan;7(1):75-83 [8423065] J Biol Chem. 1993 Oct 25;268(30):22908-13 [8226800] Br J Anaesth. 1996 Mar;76(3):435-45 [8785147] Am J Pathol. 1997 Feb;150(2):617-30 [9033275] J Neurosci. 1997 Jul 1;17(13):5089-100 [9185546] Science. 1999 Jan 1;283(5398):70-4 [9872743] J Neurochem. 1999 Apr;72(4):1617-24 [10098869] Brain Res. 2005 Feb 21;1035(1):24-31 [15713273] Mass Spectrom Rev. 2005 May-Jun;24(3):367-412 [15389848] J Lipid Res. 2005 Jul;46(7):1548-60 [15834120] Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10858-63 [16040805] Nat Biotechnol. 2006 Sep;24(9):1151-61 [16964229] J Biol Chem. 2007 Feb 9;282(6):3614-23 [17158102] Toxicol Sci. 2007 Jul;98(1):145-58 [17426105] J Biol Chem. 2007 Jun 29;282(26):18661-5 [17488715] J Am Assoc Lab Anim Sci. 2007 Nov;46(6):21-8 [17994669] J Neurosci. 2008 Feb 13;28(7):1721-7 [18272692] Rapid Commun Mass Spectrom. 2008 Jul;22(13):2115-24 [18523984] BMC Bioinformatics. 2008;9 Suppl 9:S10 [18793455] Neurotoxicology. 2013 Dec;39:45-56 [23994303] Anesthesiology. 2014 Feb;120(2):403-15 [24061597] J Neural Transm (Vienna). 2000;107(8-9):1027-63 [11041281] J Neurosurg Anesthesiol. 2008 Oct;20(4):233-40 [18812886] Nat Neurosci. 2008 Nov;11(11):1311-8 [18931664] Anal Chem. 2009 Jun 1;81(11):4356-68 [19408941] Curr Med Chem. 2009;16(16):2021-41 [19519379] J Neuroimmunol. 2009 Jul 25;212(1-2):17-25 [19457561] Neuroscience. 2010 Mar 31;166(3):852-63 [20080153] Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):165-72 [20207120] Anesthesiology. 2010 Jun;112(6):1404-16 [20460993] Anesthesiology. 2010 Jun;112(6):1325-34 [20460994] Biochim Biophys Acta. 2010 Aug;1801(8):774-83 [20117236] Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20936-41 [19926863] J Cell Biol. 2011 Mar 21;192(6):979-92 [21402788] Neurotoxicol Teratol. 2011 Mar-Apr;33(2):220-30 [21241795] Int J Dev Neurosci. 2011 May;29(3):351-8 [20691775] Neurotoxicol Teratol. 2011 Sep-Oct;33(5):592-7 [21708249] Neuroscience. 2012 Mar 15;205:167-77 [22244976] Anal Chem. 2012 May 15;84(10):4580-6 [22500579] Neurol Sci. 2012 Jun;33(3):535-44 [21948083] Biochim Biophys Acta. 2013 Mar;1831(3):543-54 [22960354] J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2673-95 [19269264] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv150 ER - TY - JOUR T1 - Effects of amorphous silica coating on cerium oxide nanoparticles induced pulmonary responses. AN - 1715661491; 26210349 AB - Recently cerium compounds have been used in a variety of consumer products, including diesel fuel additives, to increase fuel combustion efficiency and decrease diesel soot emissions. However, cerium oxide (CeO2) nanoparticles have been detected in the exhaust, which raises a health concern. Previous studies have shown that exposure of rats to nanoscale CeO2 by intratracheal instillation (IT) induces sustained pulmonary inflammation and fibrosis. In the present study, male Sprague-Dawley rats were exposed to CeO2 or CeO2 coated with a nano layer of amorphous SiO2 (aSiO2/CeO2) by a single IT and sacrificed at various times post-exposure to assess potential protective effects of the aSiO2 coating. The first acellular bronchoalveolar lavage (BAL) fluid and BAL cells were collected and analyzed from all exposed animals. At the low dose (0.15mg/kg), CeO2 but not aSiO2/CeO2 exposure induced inflammation. However, at the higher doses, both particles induced a dose-related inflammation, cytotoxicity, inflammatory cytokines, matrix metalloproteinase (MMP)-9, and tissue inhibitor of MMP at 1day post-exposure. Morphological analysis of lung showed an increased inflammation, surfactant and collagen fibers after CeO2 (high dose at 3.5mg/kg) treatment at 28days post-exposure. aSiO2 coating significantly reduced CeO2-induced inflammatory responses in the airspace and appeared to attenuate phospholipidosis and fibrosis. Energy dispersive X-ray spectroscopy analysis showed Ce and phosphorous (P) in all particle-exposed lungs, whereas Si was only detected in aSiO2/CeO2-exposed lungs up to 3days after exposure, suggesting that aSiO2 dissolved off the CeO2 core, and some of the CeO2 was transformed to CePO4 with time. These results demonstrate that aSiO2 coating reduce CeO2-induced inflammation, phospholipidosis and fibrosis. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Ma, Jane AU - Mercer, Robert R AU - Barger, Mark AU - Schwegler-Berry, Diane AU - Cohen, Joel M AU - Demokritou, Philip AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Electronic address: jym1@cdc.gov. ; Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA. ; Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA. ; School of Pharmacy, West Virginia University, Morgantown, WV, USA. Y1 - 2015/10/01/ PY - 2015 DA - 2015 Oct 01 SP - 63 EP - 73 VL - 288 IS - 1 KW - Anti-Inflammatory Agents KW - 0 KW - Cytokines KW - Inflammation Mediators KW - Phospholipids KW - Pulmonary Surfactant-Associated Proteins KW - Tissue Inhibitor of Metalloproteinases KW - Cerium KW - 30K4522N6T KW - ceric oxide KW - 619G5K328Y KW - Silicon Dioxide KW - 7631-86-9 KW - Collagen KW - 9007-34-5 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Mmp9 protein, rat KW - Index Medicus KW - Safer by design KW - Lung inflammation KW - Pulmonary fibrosis KW - Cerium oxide, amorphous silica KW - Animals KW - Spectrometry, X-Ray Emission KW - Collagen -- metabolism KW - Dose-Response Relationship, Drug KW - Tissue Inhibitor of Metalloproteinases -- metabolism KW - Phospholipids -- metabolism KW - Cytoprotection KW - Cytokines -- metabolism KW - Inflammation Mediators -- metabolism KW - Matrix Metalloproteinase 9 -- metabolism KW - Rats, Sprague-Dawley KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Pulmonary Surfactant-Associated Proteins -- metabolism KW - Time Factors KW - Male KW - Surface Properties KW - Silicon Dioxide -- pharmacology KW - Pneumonia -- prevention & control KW - Pneumonia -- chemically induced KW - Metal Nanoparticles -- chemistry KW - Metal Nanoparticles -- toxicity KW - Lung -- metabolism KW - Lung -- pathology KW - Cerium -- chemistry KW - Cerium -- toxicity KW - Silicon Dioxide -- chemistry KW - Pneumonia -- pathology KW - Pulmonary Fibrosis -- metabolism KW - Anti-Inflammatory Agents -- chemistry KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Pulmonary Fibrosis -- prevention & control KW - Lung -- drug effects KW - Pneumonia -- metabolism KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1715661491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Effects+of+amorphous+silica+coating+on+cerium+oxide+nanoparticles+induced+pulmonary+responses.&rft.au=Ma%2C+Jane%3BMercer%2C+Robert+R%3BBarger%2C+Mark%3BSchwegler-Berry%2C+Diane%3BCohen%2C+Joel+M%3BDemokritou%2C+Philip%3BCastranova%2C+Vincent&rft.aulast=Ma&rft.aufirst=Jane&rft.date=2015-10-01&rft.volume=288&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-15 N1 - Date created - 2015-09-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2014 Jul 15;278(2):135-47 [24793434] Environ Health Perspect. 2007 May;115(5):728-33 [17520060] Toxicol Sci. 2014 Dec;142(2):403-17 [25239632] Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L562-74 [10956632] Toxicol Sci. 2000 May;55(1):24-35 [10788556] J Trace Elem Med Biol. 2001 Apr;14(4):232-6 [11396783] Environ Health Perspect. 2001 May;109(5):515-21 [11401764] Arch Toxicol. 2002 Jan;75(11-12):625-34 [11876495] Histochem J. 1979 Jul;11(4):447-55 [91593] Sci Total Environ. 1982 Dec;26(1):19-32 [7167813] Fundam Appl Toxicol. 1985 Apr;5(2):240-50 [2580752] Am J Ind Med. 1995 Mar;27(3):349-58 [7747741] Mod Pathol. 1995 Oct;8(8):859-65 [8552576] Scand J Work Environ Health. 1995;21 Suppl 2:19-21 [8929682] Microsc Res Tech. 1997 Feb 15;36(4):313-23 [9140931] Toxicol Lett. 2007 Dec 10;175(1-3):24-33 [17981407] Curr Opin Biotechnol. 2007 Dec;18(6):565-71 [18160274] Anal Chim Acta. 2009 Oct 27;653(2):191-9 [19808113] Ind Health. 2010;48(1):3-11 [20160402] Nanotechnology. 2010 Jul 16;21(28):285103 [20562477] Toxicol Lett. 2011 Aug 28;205(2):105-15 [21624445] Nanotoxicology. 2011 Sep;5(3):312-25 [20925443] Int J Nanomedicine. 2011;6:2327-35 [22072870] Environ Res. 2012 May;115:1-10 [22507957] Toxicol Appl Pharmacol. 2012 Aug 1;262(3):255-64 [22613087] Nanotoxicology. 2014 Aug;8 Suppl 1:216-25 [24479615] Am J Respir Cell Mol Biol. 1999 May;20(5):903-13 [10226060] Toxicol Ind Health. 2004 Jun;20(1-5):21-7 [15807405] Eur J Pharmacol. 2006 Mar 8;533(1-3):133-44 [16487964] Nanotoxicology. 2013 Dec;7(8):1338-50 [23061914] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.07.012 ER - TY - JOUR T1 - Establishing best practise in the application of expert review of mutagenicity under ICH M7. AN - 1712523189; 26248005 AB - The ICH M7 guidelines for the assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals allows for the consideration of in silico predictions in place of in vitro studies. This represents a significant advance in the acceptance of (Q)SAR models and has resulted from positive interactions between modellers, regulatory agencies and industry with a shared purpose of developing effective processes to minimise risk. This paper discusses key scientific principles that should be applied when evaluating in silico predictions with a focus on accuracy and scientific rigour that will support a consistent and practical route to regulatory submission. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Barber, Chris AU - Amberg, Alexander AU - Custer, Laura AU - Dobo, Krista L AU - Glowienke, Susanne AU - Van Gompel, Jacky AU - Gutsell, Steve AU - Harvey, Jim AU - Honma, Masamitsu AU - Kenyon, Michelle O AU - Kruhlak, Naomi AU - Muster, Wolfgang AU - Stavitskaya, Lidiya AU - Teasdale, Andrew AU - Vessey, Jonathan AU - Wichard, Joerg AD - Lhasa Limited, Leeds, UK. Electronic address: chris.barber@lhasalimited.org. ; Sanofi-Aventis Deutschland GmbH, DSAR Preclinical Safety, Frankfurt, Germany. ; Bristol-Myers Squibb, Drug Safety Evaluation, New Brunswick, USA. ; Pfizer, Drug Safety Research and Development, Groton, CT, USA. ; Novartis Institutes for Biomedical Research, Department of Preclinical Safety, Basel, Switzerland. ; Janssen, Drug Safety Sciences, Beerse, Belgium. ; Unilever, Safety and Environmental Assurance Centre, Colworth, Beds, UK. ; GlaxoSmithkline, Computational Toxicology, Ware, Herts, UK. ; National Institute of Health Sciences, Tokyo, Japan. ; FDA Center for Drug Evaluation and Research, Silver Spring, MD, USA. ; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Basel, Switzerland. ; AstraZeneca, Macclesfield, Cheshire, UK. ; Lhasa Limited, Leeds, UK. ; Bayer, HealthCare, Genetic Toxicology, Berlin, Germany. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 367 EP - 377 VL - 73 IS - 1 KW - Mutagens KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - In silico KW - ICH M7 KW - Statistical KW - Mutagenicity KW - Expert rule-based KW - Genotoxicity KW - Ames KW - Drug Contamination -- prevention & control KW - Quantitative Structure-Activity Relationship KW - Computer Simulation -- standards KW - DNA -- chemistry KW - Mutagenicity Tests -- methods KW - Mutagenicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712523189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Establishing+best+practise+in+the+application+of+expert+review+of+mutagenicity+under+ICH+M7.&rft.au=Barber%2C+Chris%3BAmberg%2C+Alexander%3BCuster%2C+Laura%3BDobo%2C+Krista+L%3BGlowienke%2C+Susanne%3BVan+Gompel%2C+Jacky%3BGutsell%2C+Steve%3BHarvey%2C+Jim%3BHonma%2C+Masamitsu%3BKenyon%2C+Michelle+O%3BKruhlak%2C+Naomi%3BMuster%2C+Wolfgang%3BStavitskaya%2C+Lidiya%3BTeasdale%2C+Andrew%3BVessey%2C+Jonathan%3BWichard%2C+Joerg&rft.aulast=Barber&rft.aufirst=Chris&rft.date=2015-10-01&rft.volume=73&rft.issue=1&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.07.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-28 N1 - Date created - 2015-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.07.018 ER - TY - JOUR T1 - Bayesian evaluation of a physiologically-based pharmacokinetic (PBPK) model of long-term kinetics of metal nanoparticles in rats. AN - 1712522678; 26145831 AB - Biomathematical modeling quantitatively describes the disposition of metal nanoparticles in lungs and other organs of rats. In a preliminary model, adjustable parameters were calibrated to each of three data sets using a deterministic approach, with optimal values varying among the different data sets. In the current effort, Bayesian population analysis using Markov chain Monte Carlo (MCMC) simulation was used to recalibrate the model while improving assessments of parameter variability and uncertainty. The previously-developed model structure and some physiological parameter values were modified to improve physiological realism. The data from one of the three previously-identified studies and from two other studies were used for model calibration. The data from the one study that adequately characterized mass balance were used to generate parameter distributions. When data from a second study of the same nanomaterial (iridium) were added, the level of agreement was still acceptable. Addition of another data set (for silver nanoparticles) led to substantially lower precision in parameter estimates and large discrepancies between the model predictions and experimental data for silver nanoparticles. Additional toxicokinetic data are needed to further evaluate the model structure and performance and to reduce uncertainty in the kinetic processes governing in vivo disposition of metal nanoparticles. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Sweeney, Lisa M AU - MacCalman, Laura AU - Haber, Lynne T AU - Kuempel, Eileen D AU - Tran, C Lang AD - Henry M. Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton (NAMRU Dayton), 2729 R Street, Building 837, Wright Patterson Air Force Base, OH 45433, USA; Toxicology Excellence for Risk Assessment (TERA), 2300 Montana Avenue, Cincinnati, OH 45211, USA. Electronic address: LMS29@cwru.edu. ; Institute of Occupational Medicine, Research Avenue North, Riccarton, Edinburgh EH14 4AP, UK. ; Toxicology Excellence for Risk Assessment (TERA), 2300 Montana Avenue, Cincinnati, OH 45211, USA. ; National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, M.S. C-15, Cincinnati, OH 45226-1998, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 151 EP - 163 VL - 73 IS - 1 KW - Index Medicus KW - Physiologically-based pharmacokinetic model KW - Bayesian analysis KW - Nanoparticles KW - Markov chain Monte Carlo KW - Rats KW - Uncertainty KW - Animals KW - Kinetics KW - Rats, Wistar KW - Bayes Theorem KW - Calibration KW - Markov Chains KW - Monte Carlo Method KW - Models, Biological KW - Male KW - Models, Theoretical KW - Metal Nanoparticles -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712522678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Bayesian+evaluation+of+a+physiologically-based+pharmacokinetic+%28PBPK%29+model+of+long-term+kinetics+of+metal+nanoparticles+in+rats.&rft.au=Sweeney%2C+Lisa+M%3BMacCalman%2C+Laura%3BHaber%2C+Lynne+T%3BKuempel%2C+Eileen+D%3BTran%2C+C+Lang&rft.aulast=Sweeney&rft.aufirst=Lisa&rft.date=2015-10-01&rft.volume=73&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.06.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-28 N1 - Date created - 2015-09-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2000 Feb 15;163(1):67-74 [10662606] J Pharmacokinet Pharmacodyn. 2009 Feb;36(1):19-38 [19132515] Toxicol Lett. 2009 May 8;186(3):152-9 [19114093] Toxicol Appl Pharmacol. 2009 May 1;236(3):329-40 [19249323] Inhal Toxicol. 2009 Jul;21 Suppl 1:55-60 [19558234] Toxicology. 2009 Sep 19;263(2-3):117-26 [19615422] Toxicol Appl Pharmacol. 2009 Nov 15;241(1):36-60 [19660485] Inhal Toxicol. 2009 Nov;21(13):1099-107 [19814607] Biomaterials. 2010 Nov;31(32):8350-61 [20684985] Toxicol Sci. 2010 Dec;118(2):470-84 [20833708] ACS Nano. 2010 Nov 23;4(11):6303-17 [20945925] J Nanosci Nanotechnol. 2010 Dec;10(12):8482-90 [21121357] Nat Biotechnol. 2010 Dec;28(12):1300-3 [21057497] Int J Nanomedicine. 2012;7:1345-56 [22419876] J Appl Toxicol. 2012 Nov;32(11):920-8 [22696427] Int J Nanomedicine. 2013;8:3365-82 [24039420] Nanotoxicology. 2014 Mar;8(2):132-41 [23272772] J Toxicol Environ Health A. 2000 Aug 25;60(8):531-48 [10983521] Environ Health Perspect. 2000 Oct;108 Suppl 5:883-93 [11035998] Environ Health Perspect. 2001 Aug;109 Suppl 4:547-51 [11544161] J Toxicol Environ Health A. 2002 Oct 25;65(20):1513-30 [12396866] Toxicol Lett. 2003 Feb 18;138(1-2):143-50 [12559698] Inhal Toxicol. 2004 Jun;16(6-7):453-9 [15204761] Gut. 1989 Apr;30(4):455-9 [2714679] Toxicol Lett. 1994 Dec;74(3):189-201 [7871543] Cancer Res. 1996 Aug 15;56(16):3771-81 [8706023] Risk Anal. 2004 Dec;24(6):1697-717 [15660623] Toxicology. 2006 Apr 17;221(2-3):241-8 [16466842] Regul Toxicol Pharmacol. 2006 Oct;46(1):63-83 [16889879] Environ Health Perspect. 2007 May;115(5):728-33 [17520060] Nat Biotechnol. 2007 Oct;25(10):1165-70 [17891134] Arch Toxicol. 2008 Mar;82(3):151-7 [18000654] Toxicol Sci. 2009 Feb;107(2):342-51 [19023088] Nanotoxicology. 2014 Aug;8 Suppl 1:128-37 [24392664] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.06.019 ER - TY - JOUR T1 - Chronic MPTP treatment produces hyperactivity in male mice which is not alleviated by concurrent trehalose treatment. AN - 1709396567; 26111725 AB - The chronic MPTP+probenecid treatment paradigm has been used to successfully model the neurochemical, neuropathological, and behavioral effects associated with Parkinson's disease. Here, adult male C57Bl/6 mice were injected ip with 25 mg/kg MPTP and 250 mg/kg probenecid (MPTPp) or saline twice weekly for a total of 10 injections. Behavioral assessments included motor coordination, grip strength, spatial learning/memory, locomotor activity, and anhedonia. Those assessments were repeated up to 8 weeks post-treatment. In a subsequent experiment, adult male mice were treated with saline or MPTPp as described above. One-half of each group was allowed access to 1% trehalose in the water bottle. Trehalose intake averaged 1.90-2.34 g/kg. Behavioral assessments included locomotor activity, olfaction, motor coordination, grip strength, and exploratory behavior. Those assessments were repeated 4 weeks post-treatment. The strongest MPTPp effect was hyperactivity as exhibited in the open field. This increased activity was apparent in both experiments and occurred at all time points post-treatment. Assessments of grip strength, water maze performance, olfaction, and exploratory behavior did not indicate MPTPp-related alterations. When the specifications for the motor coordination test were made somewhat easier in the second experiment, there were deficits exhibited by the MPTPp group, the MPTPp+trehalose group and the trehalose group. The addition of trehalose did not alleviate any of the MPTPp-induced behavioral alterations; however, trehalose treatment significantly attenuated the striatal decreases in DA, DOPAC, HVA and 5-HIAA. These results provide a more comprehensive description of the behavioral alterations resulting from the chronic MPTPp treatment regimen and suggest that trehalose at this concentration does not act as a complete neuroprotectant. Published by Elsevier B.V. JF - Behavioural brain research AU - Ferguson, Sherry A AU - Law, C Delbert AU - Sarkar, Sumit AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA. Electronic address: Sherry.Ferguson@fda.hhs.gov. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA. Electronic address: Charles.Law@fda.hhs.gov. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA. Electronic address: Sumit.Sarkar@fda.hhs.gov. Y1 - 2015/10/01/ PY - 2015 DA - 2015 Oct 01 SP - 68 EP - 78 VL - 292 KW - Neuroprotective Agents KW - 0 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Trehalose KW - B8WCK70T7I KW - Probenecid KW - PO572Z7917 KW - Index Medicus KW - Parkinson’s disease KW - Behavior KW - MPTP KW - Locomotor activity KW - Mice KW - Behavior, Animal -- drug effects KW - Animals KW - Probenecid -- administration & dosage KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Motor Activity -- drug effects KW - Male KW - Neuroprotective Agents -- pharmacology KW - MPTP Poisoning -- drug therapy KW - Trehalose -- pharmacology KW - Hyperkinesis -- chemically induced KW - Hyperkinesis -- drug therapy KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- administration & dosage KW - MPTP Poisoning -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709396567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Chronic+MPTP+treatment+produces+hyperactivity+in+male+mice+which+is+not+alleviated+by+concurrent+trehalose+treatment.&rft.au=Ferguson%2C+Sherry+A%3BLaw%2C+C+Delbert%3BSarkar%2C+Sumit&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2015-10-01&rft.volume=292&rft.issue=&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=1872-7549&rft_id=info:doi/10.1016%2Fj.bbr.2015.05.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-14 N1 - Date created - 2015-09-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbr.2015.05.057 ER - TY - JOUR T1 - Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells. AN - 1709395554; 26055230 AB - Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day 16 rat fetuses. On the eighth day in culture, proliferating neural stem cells were exposed for 24 h to ketamine at 1, 10, 100, and 500 μM. To determine the effect of ketamine on differentiated stem cells, separate cultures of neural stem cells were maintained in transition medium (DIV 6) for 1 day and kept in differentiation medium for another 3 days. Differentiated neural cells were exposed for 24 h to 10 μM ketamine. Markers of cellular proliferation and differentiation, mitochondrial health, cell death/damage, and oxidative damage were monitored to determine: (1) the effects of ketamine on neural stem cell proliferation and neural stem cell differentiation; (2) the nature and degree of ketamine-induced toxicity in proliferating neural stem cells and differentiated neural cells; and (3) to provide information regarding receptor expression and possible mechanisms underlying ketamine toxicity. After ketamine exposure at a clinically relevant concentration (10 μM), neural stem cell proliferation was not significantly affected and oxidative DNA damage was not induced. No significant effect on mitochondrial viability (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay) in neural stem cell cultures (growth medium) was observed at ketamine concentrations up to 500 μM. However, quantitative analysis shows that the number of differentiated neurons was substantially reduced in 10 μM ketamine-exposed cultures in differentiation medium, compared with the controls. No significant changes in the number of GFAP-positive astrocytes and O4-positive oligodendrocytes (in differentiation medium) were detected from ketamine-exposed cultures. The discussion focuses on: (1) the doses and time-course over which ketamine is associated with damage of neural cells; (2) how ketamine directs or signals neural stem cells/neural cells to undergo apoptosis or necrosis; (3) how functional neuronal transmitter receptors affect neurotoxicity induced by ketamine; and (4) advantages of using neural stem cell models to study critical issues related to ketamine anesthesia. JF - Molecular neurobiology AU - Slikker, William AU - Liu, Fang AU - Rainosek, Shuo W AU - Patterson, Tucker A AU - Sadovova, Natalya AU - Hanig, Joseph P AU - Paule, Merle G AU - Wang, Cheng AD - Office of the Director, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR, 72079, USA, William.slikker@fda.hhs.gov. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 959 EP - 969 VL - 52 IS - 2 KW - Culture Media KW - 0 KW - Intercellular Signaling Peptides and Proteins KW - N-Methylaspartate KW - 6384-92-5 KW - Ketamine KW - 690G0D6V8H KW - Calcium KW - SY7Q814VUP KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Cerebral Cortex -- cytology KW - Animals KW - Oligodendroglia -- drug effects KW - DNA Damage KW - Astrocytes -- drug effects KW - Nerve Degeneration -- chemically induced KW - Intercellular Signaling Peptides and Proteins -- pharmacology KW - Culture Media -- pharmacology KW - Calcium -- metabolism KW - Rats KW - Necrosis KW - Cerebral Cortex -- embryology KW - Glycine -- pharmacology KW - Apoptosis -- drug effects KW - Mitochondria -- drug effects KW - Nerve Degeneration -- pathology KW - Astrocytes -- cytology KW - Dose-Response Relationship, Drug KW - Cell Division -- drug effects KW - Neurogenesis -- drug effects KW - Oligodendroglia -- cytology KW - Rats, Sprague-Dawley KW - Extracellular Fluid -- metabolism KW - Cells, Cultured KW - N-Methylaspartate -- pharmacology KW - Ketamine -- toxicity KW - Neurons -- drug effects KW - Neurons -- cytology KW - Neural Stem Cells -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709395554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+neurobiology&rft.atitle=Ketamine-Induced+Toxicity+in+Neurons+Differentiated+from+Neural+Stem+Cells.&rft.au=Slikker%2C+William%3BLiu%2C+Fang%3BRainosek%2C+Shuo+W%3BPatterson%2C+Tucker+A%3BSadovova%2C+Natalya%3BHanig%2C+Joseph+P%3BPaule%2C+Merle+G%3BWang%2C+Cheng&rft.aulast=Slikker&rft.aufirst=William&rft.date=2015-10-01&rft.volume=52&rft.issue=2&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Molecular+neurobiology&rft.issn=1559-1182&rft_id=info:doi/10.1007%2Fs12035-015-9248-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-21 N1 - Date created - 2015-09-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s12035-015-9248-5 ER - TY - JOUR T1 - Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage. AN - 1709395553; 26099304 AB - Various iron-oxide nanoparticles have been in use for a long time as therapeutic and imaging agents and for supplemental delivery in cases of iron-deficiency. While all of these products have a specified size range of ∼ 40 nm and above, efforts are underway to produce smaller particles, down to ∼ 1 nm. Here, we show that after a 24-h exposure of SHSY-5Y human neuroblastoma cells to 10 μg/ml of 10 and 30 nm ferric oxide nanoparticles (Fe-NPs), cellular dopamine content was depleted by 68 and 52 %, respectively. Increases in activated tyrosine kinase c-Abl, a molecular switch induced by oxidative stress, and neuronal α-synuclein expression, a protein marker associated with neuronal injury, were also observed (55 and 38 % percent increases, respectively). Inhibition of cell-proliferation, significant reductions in the number of active mitochondria, and a dose-dependent increase in reactive oxygen species (ROS) were observed in neuronal cells. Additionally, using a rat in vitro blood-brain barrier (BBB) model, a dose-dependent increase in ROS accompanied by increased fluorescein efflux demonstrated compromised BBB integrity. To assess translational implications, in vivo Fe-NP-induced neurotoxicity was determined using in vivo MRI and post-mortem neurochemical and neuropathological correlates in adult male rats after exposure to 50 mg/kg of 10 nm Fe-NPs. Significant decrease in T 2 values was observed. Dynamic observations suggested transfer and retention of Fe-NPs from brain vasculature into brain ventricles. A significant decrease in striatal dopamine and its metabolites was also observed, and neuropathological correlates provided additional evidence of significant nerve cell body and dopaminergic terminal damage as well as damage to neuronal vasculature after exposure to 10 nm Fe-NPs. These data demonstrate a neurotoxic potential of very small size iron nanoparticles and suggest that use of these ferric oxide nanoparticles may result in neurotoxicity, thereby limiting their clinical application. JF - Molecular neurobiology AU - Imam, Syed Z AU - Lantz-McPeak, Susan M AU - Cuevas, Elvis AU - Rosas-Hernandez, Hector AU - Liachenko, Serguei AU - Zhang, Yongbin AU - Sarkar, Sumit AU - Ramu, Jaivijay AU - Robinson, Bonnie L AU - Jones, Yvonne AU - Gough, Bobby AU - Paule, Merle G AU - Ali, Syed F AU - Binienda, Zbigniew K AD - Division of Neurotoxicology, US FDA/National Center for Toxicological Research, Jefferson, AR, USA, Syed.Imam@fda.hhs.gov. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 913 EP - 926 VL - 52 IS - 2 KW - Catecholamines KW - 0 KW - Magnetite Nanoparticles KW - Reactive Oxygen Species KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Neuroblastoma -- pathology KW - Magnetic Resonance Imaging KW - Animals KW - Spectrometry, X-Ray Emission KW - Nanospheres KW - Particle Size KW - Humans KW - Cell Division -- drug effects KW - Cell Line, Tumor KW - Reactive Oxygen Species -- analysis KW - Caspases -- metabolism KW - Magnetic Resonance Spectroscopy KW - Rats KW - Blood-Brain Barrier -- drug effects KW - Permeability -- drug effects KW - Rats, Sprague-Dawley KW - Corpus Striatum -- chemistry KW - Oxidative Stress KW - Mitochondria -- drug effects KW - Apoptosis -- drug effects KW - Enzyme Activation -- drug effects KW - Mitochondria -- metabolism KW - Corpus Striatum -- drug effects KW - Catecholamines -- analysis KW - Male KW - Dopaminergic Neurons -- drug effects KW - Dopaminergic Neurons -- chemistry KW - Magnetite Nanoparticles -- toxicity KW - Dopaminergic Neurons -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709395553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+BROMODICHLOROACETIC+ACID+%28CAS+NO.+71133-14-7%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+BROMODICHLOROACETIC+ACID+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-10-01&rft.volume=&rft.issue=583&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-21 N1 - Date created - 2015-09-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s12035-015-9259-2 ER - TY - JOUR T1 - Estrogen Selectively Mobilizes Neural Stem Cells in the Third Ventricle Stem Cell Niche of Postnatal Day 21 Rats. AN - 1709392787; 26041664 AB - The neuroprotective properties of stem cells have been described for various pathophysiological states. Here, we determined the effects of exogenous perinatal estrogen treatment on endogenous neural stem cell activity in the third ventricle stem cell niche (3VSCN) and the caudal third ventricle (C3V). Pregnant Sprague-Dawley rats were gavaged with ethinyl estradiol (EE2, 10 μg/kg/day) or vehicle on gestational days 6-21, and their offspring were similarly treated from birth to weaning on postnatal day 21. At weaning, neural stem cell activity was investigated using the stem cell markers nestin, Ki-67, phosphohistone H3 (PHH3), and doublecortin (DCX). The 3VSCN was characterized by nestin labeling, but little DCX labeling, while both the subventricular (SVZ) and subgranular zones (SGZ) displayed robust DCX expression. Ki-67 cell counts in the 3VSCN were 2.2 to 6.4 times those of the C3V. In the 3VSCN, EE2 treatment significantly increased Ki-67, PHH3, and co-labeled cell counts by 135-207 %, effects which appeared stronger in females. EE2 treatment had only marginally significant effects in the C3V, mildly increasing PHH3 and co-labeled cell counts. Perinatal estrogen treatment selectively increased and mobilized proliferative cells in the 3VSCN at weaning, potentially providing increased neuroprotection. Because PHH3 cells are thought to be in the mitotic phase of the cell cycle and Ki-67 cells can be found in most phases of the cycle, the effect of estrogen treatment on 3VSCN cells appears to involve enhancement of mitosis. JF - Molecular neurobiology AU - He, Zhen AU - Cui, Li AU - Paule, Merle G AU - Ferguson, Sherry A AD - HFT-132, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA, Zhen.He@fda.hhs.gov. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 927 EP - 933 VL - 52 IS - 2 KW - Histones KW - 0 KW - Ki-67 Antigen KW - Microtubule-Associated Proteins KW - Nerve Tissue Proteins KW - Neuropeptides KW - doublecortin protein KW - Ethinyl Estradiol KW - 423D2T571U KW - Index Medicus KW - Protein Processing, Post-Translational -- drug effects KW - Animals KW - Sex Factors KW - Ki-67 Antigen -- analysis KW - Weaning KW - Microtubule-Associated Proteins -- biosynthesis KW - Nerve Tissue Proteins -- biosynthesis KW - Neuropeptides -- biosynthesis KW - Nerve Tissue Proteins -- genetics KW - Pregnancy KW - Phosphorylation -- drug effects KW - Rats KW - Rats, Sprague-Dawley KW - Microtubule-Associated Proteins -- genetics KW - Histones -- metabolism KW - Mitosis -- drug effects KW - Female KW - Male KW - Prenatal Exposure Delayed Effects KW - Neuropeptides -- genetics KW - Stem Cell Niche -- drug effects KW - Third Ventricle -- cytology KW - Third Ventricle -- growth & development KW - Neural Stem Cells -- drug effects KW - Neural Stem Cells -- cytology KW - Ethinyl Estradiol -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709392787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+neurobiology&rft.atitle=Estrogen+Selectively+Mobilizes+Neural+Stem+Cells+in+the+Third+Ventricle+Stem+Cell+Niche+of+Postnatal+Day+21+Rats.&rft.au=He%2C+Zhen%3BCui%2C+Li%3BPaule%2C+Merle+G%3BFerguson%2C+Sherry+A&rft.aulast=He&rft.aufirst=Zhen&rft.date=2015-10-01&rft.volume=52&rft.issue=2&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Molecular+neurobiology&rft.issn=1559-1182&rft_id=info:doi/10.1007%2Fs12035-015-9244-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-21 N1 - Date created - 2015-09-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s12035-015-9244-9 ER - TY - JOUR T1 - Pharmacokinetics of bisphenol A in humans following a single oral administration. AN - 1705735125; 26115537 AB - Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA. To reduce uncertainties about the metabolism and excretion of BPA in humans following oral administration. We exposed six men and eight women to 100 μg/kg bw of deuterated BPA (d6-BPA) by oral administration and conducted blood and urine analysis over a three day period. The use of d6-BPA allowed administered d6-BPA to be distinguished from background native (unlabeled) BPA. We calculated the rate of oral absorption, serum elimination, half-life, area under the curve (AUC), urinary excretion, and metabolism to glucuronide and sulfate conjugates. Mean serum total (unconjugated and conjugated) d6-BPA Cmax of 1711 nM (390 ng/ml) was observed at Tmax of 1.1 ± 0.50h. Unconjugated d6-BPA appeared in serum within 5-20 min of dosing with a mean Cmax of 6.5 nM (1.5 ng/ml) observed at Tmax of 1.3 ± 0.52 h. Detectable blood levels of unconjugated or total d6-BPA were observed at 48 h in some subjects at concentrations near the LOD (0.001-0.002 ng/ml). The half-times for terminal elimination of total d6-BPA and unconjugated d6-BPA were 6.4 ± 2.0 h and 6.2 ± 2.6h, respectively. Recovery of total administered d6-BPA in urine was 84-109%. Most subjects (10 of 14) excreted >90% as metabolites within 24h. Using more sensitive methods, our study expands the findings of other human oral pharmacokinetic studies. Conjugation reactions are rapid and nearly complete with unconjugated BPA comprising less than 1% of the total d6-BPA in blood at all times. Elimination of conjugates into urine largely occurs within 24h. Published by Elsevier Ltd. JF - Environment international AU - Thayer, Kristina A AU - Doerge, Daniel R AU - Hunt, Dawn AU - Schurman, Shepherd H AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Garantziotis, Stavros AU - Kissling, Grace E AU - Easterling, Michael R AU - Bucher, John R AU - Birnbaum, Linda S AD - Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA. Electronic address: thayer@niehs.nih.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, NCTR-53C RM204L HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: daniel.doerge@fda.hhs.gov. ; Clinical Research Unit, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop CU-01, Research Triangle Park, NC 27709, USA. Electronic address: dawnhunt2233@outlook.com. ; Clinical Research Unit, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop CU-01, Research Triangle Park, NC 27709, USA. Electronic address: schurmansh@niehs.nih.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, NCTR-53C RM204L HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: Nathan.Twaddle@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, NCTR-53C RM204L HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: Mona.Churchwell@fda.hhs.gov. ; Clinical Research Unit, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop CU-01, Research Triangle Park, NC 27709, USA. Electronic address: garantziotis@niehs.nih.gov. ; Biostatistics Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, Mail Drop A3-03, Research Triangle Park, NC 27709, USA. Electronic address: kissling@niehs.nih.gov. ; Social & Scientific Systems, Inc., 1009 Slater Rd # 120, Durham, NC 27703, USA. Electronic address: MEasterling@s-3.com. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA. Electronic address: bucher@niehs.nih.gov. ; National Cancer Institute, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop B2-01, Research Triangle Park, NC 27709, USA. Electronic address: birnbaumls@niehs.nih.gov. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 107 EP - 115 VL - 83 KW - Benzhydryl Compounds KW - 0 KW - Environmental Pollutants KW - Glucuronides KW - Phenols KW - Sulfuric Acid Esters KW - bisphenol A glucuronide KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Bioavailability KW - ADME KW - Endocrine disruptor KW - Excretion KW - Metabolism KW - Deuterated bisphenol A KW - Administration, Oral KW - Sulfuric Acid Esters -- urine KW - Half-Life KW - Area Under Curve KW - Humans KW - North Carolina KW - Adult KW - Middle Aged KW - Glucuronides -- blood KW - Sulfuric Acid Esters -- blood KW - Glucuronides -- urine KW - Male KW - Female KW - Benzhydryl Compounds -- pharmacokinetics KW - Phenols -- blood KW - Phenols -- pharmacokinetics KW - Environmental Pollutants -- urine KW - Benzhydryl Compounds -- blood KW - Phenols -- urine KW - Environmental Pollutants -- blood KW - Environmental Pollutants -- pharmacokinetics KW - Benzhydryl Compounds -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705735125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Pharmacokinetics+of+bisphenol+A+in+humans+following+a+single+oral+administration.&rft.au=Thayer%2C+Kristina+A%3BDoerge%2C+Daniel+R%3BHunt%2C+Dawn%3BSchurman%2C+Shepherd+H%3BTwaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BGarantziotis%2C+Stavros%3BKissling%2C+Grace+E%3BEasterling%2C+Michael+R%3BBucher%2C+John+R%3BBirnbaum%2C+Linda+S&rft.aulast=Thayer&rft.aufirst=Kristina&rft.date=2015-10-01&rft.volume=43&rft.issue=7&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623315596382 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-04 N1 - Date created - 2015-08-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2010 Oct 1;248(1):1-11 [20655935] Anal Bioanal Chem. 2010 Sep;398(1):571-6 [20623271] Toxicol Appl Pharmacol. 2010 Sep 1;247(2):158-65 [20600215] Xenobiotica. 2010 Feb;40(2):83-92 [19916736] Philos Trans R Soc Lond B Biol Sci. 2009 Jul 27;364(1526):2063-78 [19528056] Environ Health Perspect. 2009 May;117(5):784-9 [19479022] Toxicol Appl Pharmacol. 2015 Oct 15;288(2):131-42 [25620055] NTP CERHR MON. 2008 Sep;(22):v, vii-ix, 1-64 passim [19407859] Birth Defects Res B Dev Reprod Toxicol. 2008 Jun;83(3):157-395 [18613034] Toxicol Appl Pharmacol. 2008 Apr 1;228(1):114-34 [18207480] Environ Health Perspect. 2008 Jan;116(1):39-44 [18197297] Reprod Toxicol. 2007 Aug-Sep;24(2):139-77 [17825522] Chem Res Toxicol. 2002 Oct;15(10):1281-7 [12387626] AIHAJ. 2000 Sep-Oct;61(5):649-57 [11071416] Rapid Commun Mass Spectrom. 2010 Oct 30;24(20):3011-20 [20872634] Environ Health Perspect. 2011 Apr;119(4):422-30 [20855240] Toxicol Lett. 2011 Jul 28;204(2-3):190-8 [21571050] Toxicol Appl Pharmacol. 2011 Sep 15;255(3):261-70 [21820460] Arch Toxicol. 2011 Nov;85(11):1373-81 [21404072] Toxicol Lett. 2011 Dec 15;207(3):298-305 [21983029] Clin Pharmacokinet. 2012 May 1;51(5):319-30 [22439649] J Expo Sci Environ Epidemiol. 2012 Nov;22(6):610-6 [22617719] Environ Health Perspect. 2013 Mar;121(3):283-6 [23458838] J Anal Toxicol. 2007 Apr;31(3):177-8 [17598284] Mol Cell Endocrinol. 2014 Dec;398(1-2):101-13 [25304273] PLoS One. 2014;9(10):e110509 [25337790] Toxicol Sci. 2014 Sep;141(1):292-9 [24980262] Environ Health. 2014;13(1):25 [24690217] Reprod Toxicol. 2014 Jun;45:105-16 [24582107] Environ Health Perspect. 2009 Apr;117(4):639-44 [19440505] Breast Cancer Res. 2013;15(5):403 [24083327] Environ Res. 2014 Feb;129:32-8 [24529000] Food Chem Toxicol. 2013 Dec;62:949-63 [23959105] Environ Sci Technol. 2013;47(21):12477-85 [23941471] Environ Res. 2013 Oct;126:211-4 [23899777] Environ Health Perspect. 2013 Aug;121(8):951-6 [23761051] Rev Environ Health. 2013;28(1):37-58 [23612528] Toxicol Sci. 2014 May;139(1):4-20 [24496641] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2015.06.008 ER - TY - JOUR T1 - Toxicogenomic responses of human liver HepG2 cells to silver nanoparticles. AN - 1705006806; 26014281 AB - The increased use of silver nanoparticles (AgNPs) in foods and cosmetics has raised public safety concerns. However, only limited knowledge exists on the effect of AgNPs on the cellular transcriptome. This study evaluated global gene expression profiles of human liver HepG2 cells exposed to 20 and 50 nm AgNPs for 4 and 24 h at 2.5 µg ml(-1) . Exposure to 20 nm AgNPs resulted in 811 altered genes after 4 h, but much less after 24 h. Exposure to 50 nm AgNPs showed minimal altered genes at both exposure times. The HepG2 cells responded to the toxic insult of AgNPs by transiently upregulating stress response genes such as metallothioneins and heat shock proteins. Functional analysis of the altered genes showed more than 20 major biological processes were affected, of which metabolism, development, cell differentiation and cell death were the most dominant categories. Several cellular pathways were also impacted by AgNP exposure, including the p53 signaling pathway and the NRF2-mediated oxidative stress response pathway, which may lead to increased oxidative stress and DNA damage in the cell and potentially result in genotoxicity and carcinogenicity. Together, these results indicate that HepG2 cells underwent a multitude of cellular processes in response to the toxic insult of AgNP exposure, and suggest that toxicogenomic characterization of human HepG2 cells could serve as an alternative model for assessing toxicities of NPs. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Sahu, Saura C AU - Zheng, Jiwen AU - Yourick, Jeffrey J AU - Sprando, Robert L AU - Gao, Xiugong AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA. ; Division of Chemistry and Material Sciences, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1160 EP - 1168 VL - 35 IS - 10 KW - Heat-Shock Proteins KW - 0 KW - Mutagens KW - Silver KW - 3M4G523W1G KW - RNA KW - 63231-63-0 KW - Metallothionein KW - 9038-94-2 KW - Index Medicus KW - DNA damage KW - carcinogenicity KW - Silver nanoparticles KW - HepG2 cells KW - genotoxicity KW - DNA microarray KW - toxicogenomics KW - gene expression KW - alternative model KW - oxidative stress KW - Heat-Shock Proteins -- metabolism KW - Gene Expression -- drug effects KW - Hep G2 Cells KW - Humans KW - Signal Transduction -- drug effects KW - Oxidative Stress -- drug effects KW - Microarray Analysis KW - Toxicogenetics KW - Cell Differentiation -- drug effects KW - Metallothionein -- metabolism KW - RNA -- genetics KW - RNA -- biosynthesis KW - Metal Nanoparticles -- toxicity KW - Liver -- drug effects KW - Silver -- toxicity KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705006806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Toxicogenomic+responses+of+human+liver+HepG2+cells+to+silver+nanoparticles.&rft.au=Sahu%2C+Saura+C%3BZheng%2C+Jiwen%3BYourick%2C+Jeffrey+J%3BSprando%2C+Robert+L%3BGao%2C+Xiugong&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2015-10-01&rft.volume=35&rft.issue=10&rft.spage=1160&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3170 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-17 N1 - Date created - 2015-08-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3170 ER - TY - JOUR T1 - Chemical exposures in the workplace and breast cancer risk: A prospective cohort study AN - 1701481821; PQ0001761735 AB - We investigated the relationship between workplace chemical exposures and breast cancer risk among women enrolled in the Sister Study, a prospective cohort study of US and Puerto Rican women. A total of 47,640 participants reported work outside of the home. Workplace exposure to eleven agents (acids, dyes or inks, gasoline or other petroleum products, glues or adhesives, lubricating oils, metals, paints, pesticides, soldering materials, solvents and stains or varnishes) was characterized based on self-reports of frequency and duration of use. Approximately 14% of the study population reported exposure to only one agent and 11% reported working with two or more of the 11 agents in their lifetime. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for each agent, adjusting for established breast cancer risk factors. During follow-up, 1,966 cases of breast cancer were reported. Although there were no significant associations between ever use of the eleven agents evaluated and breast cancer risk, women with cumulative exposure to gasoline or petroleum products at or above the highest quartile cutoff had an elevated risk of total (HR: 2.3, 95%CI: 1.1-4.9) and invasive (HR: 2.5, 95%CI: 1.1-5.9) breast cancer compared with women in the lowest quartile group (p sub(trend)=0.03). Workplace exposure to soldering materials was associated with an increased risk of premenopausal breast cancer (HR=1.8, 95% CI=1.1-3.0). Findings support the need for further studies to elucidate the role of occupational chemicals in breast cancer etiology. What's new? There has been widespread interest in the role of chemical exposures in the development of breast cancer, but few occupational studies have prospectively investigated breast cancer risk. The workplace is a setting where there is the potential for greater than background levels of exposure. Here, the authors investigate the association between workplace chemical exposures and incident breast cancer in 47,640 women enrolled in the Sister Study. They observe significant trends in breast cancer risk associated with increased gasoline/petroleum product use, suggesting that additional studies are warranted to examine the influence of occupational chemical exposures on breast cancer etiology. JF - International Journal of Cancer AU - Ekenga, Christine C AU - Parks, Christine G AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC. Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 1765 EP - 1774 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 137 IS - 7 SN - 0020-7136, 0020-7136 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Soldering KW - Invasiveness KW - Gasoline KW - Stains KW - Petroleum KW - Risk factors KW - Adhesives KW - Occupational exposure KW - Metals KW - Etiology KW - Solvents KW - Oils KW - Population studies KW - Cancer KW - Health risks KW - Dyes KW - Acids KW - Background levels KW - Pesticides KW - Breast cancer KW - Paints KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701481821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Chemical+exposures+in+the+workplace+and+breast+cancer+risk%3A+A+prospective+cohort+study&rft.au=Ekenga%2C+Christine+C%3BParks%2C+Christine+G%3BSandler%2C+Dale+P&rft.aulast=Ekenga&rft.aufirst=Christine&rft.date=2015-10-01&rft.volume=137&rft.issue=7&rft.spage=1765&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.29545 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-09-30 N1 - SubjectsTermNotLitGenreText - Soldering; Metals; Etiology; Invasiveness; Gasoline; Oils; Solvents; Population studies; Stains; Dyes; Risk factors; Acids; Petroleum; Pesticides; Background levels; Breast cancer; Adhesives; Occupational exposure; Paints; Cancer; Health risks DO - http://dx.doi.org/10.1002/ijc.29545 ER - TY - JOUR T1 - Perspectives on Communication and Participation in Research Notification Focus Groups AN - 1698868282 AB - Researchers are slowly acknowledging an ethical obligation to inform research participants about study findings. Research notification may help participants become aware of and manage potential health risks. Scholars and practitioners have acknowledged the need for better understanding of this process. This study investigates transcripts of focus groups conducted to gauge audience reactions to notification materials that communicate scientific research findings about occupational exposures. Focus groups are a useful way to tailor notification materials to audiences, but we caution that transmission models of communication used in risk research may obscure the full value of focus groups. The emphasis on translating scientific communication into “lay” language may overlook how scientists and lay audiences can work together to bridge differences in language, experiences, goals, and orientations toward health. This study demonstrates limitations in scientific risk communication that minimize participation in communicating science. The conclusion provides instructive insights for strengthening the process of communicating science. JF - Health Communication AU - Zoller, Heather M AU - Fujishiro, Kaori AU - Mobley, Amy AU - Lehman, Everett AD - Department of Communication, University of Cincinnati, Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health ; Department of Communication, University of Cincinnati; Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 986 EP - 1000 CY - Mahwah PB - Taylor & Francis Ltd. VL - 30 IS - 10 SN - 1041-0236 KW - Public Health And Safety KW - Audiences KW - Health risks KW - Medical research KW - Notification KW - Risk communication KW - Scientific research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698868282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Perspectives+on+Communication+and+Participation+in+Research+Notification+Focus+Groups&rft.au=Zoller%2C+Heather+M%3BFujishiro%2C+Kaori%3BMobley%2C+Amy%3BLehman%2C+Everett&rft.aulast=Zoller&rft.aufirst=Heather&rft.date=2015-10-01&rft.volume=30&rft.issue=10&rft.spage=986&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410236.2014.913221 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-07-20 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1080/10410236.2014.913221 ER - TY - JOUR T1 - Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. AN - 1718330937; 26419945 AB - Ginkgo biloba leaf extract has been shown to increase the incidence in liver tumors in mice in a 2-year bioassay conducted by the National Toxicology Program. In this study, the DNA damaging effects of Ginkgo biloba leaf extract and many of its constituents were evaluated in human hepatic HepG2 cells and the underlying mechanism was determined. A molecular docking study revealed that quercetin, a flavonoid constituent of Ginkgo biloba, showed a higher potential to interact with topoisomerase II (Topo II) than did the other Ginkgo biloba constituents; this in silico prediction was confirmed by using a biochemical assay to study Topo II enzyme inhibition. Moreover, as measured by the Comet assay and the induction of γ-H2A.X, quercetin, followed by keampferol and isorhamnetin, appeared to be the most potent DNA damage inducer in HepG2 cells. In Topo II knockdown cells, DNA damage triggered by Ginkgo biloba leaf extract or quercetin was dramatically decreased, indicating that DNA damage is directly associated with Topo II. DNA damage was also observed when cells were treated with commercially available Ginkgo biloba extract product. Our findings suggest that Ginkgo biloba leaf extract- and quercetin-induced in vitro genotoxicity may be the result of Topo II inhibition. JF - Scientific reports AU - Zhang, Zhuhong AU - Chen, Si AU - Mei, Hu AU - Xuan, Jiekun AU - Guo, Xiaoqing AU - Couch, Letha AU - Dobrovolsky, Vasily N AU - Guo, Lei AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; College of Bioengineering, Chongqing University, Chongqing 400044, China. Y1 - 2015/09/30/ PY - 2015 DA - 2015 Sep 30 SP - 14633 VL - 5 KW - Mutagens KW - 0 KW - Plant Extracts KW - Topoisomerase II Inhibitors KW - Quercetin KW - 9IKM0I5T1E KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - Index Medicus KW - Gene Silencing KW - Models, Molecular KW - Humans KW - Topoisomerase II Inhibitors -- toxicity KW - Mutagens -- toxicity KW - Mutagens -- pharmacology KW - Topoisomerase II Inhibitors -- chemistry KW - Topoisomerase II Inhibitors -- pharmacology KW - Gene Knockdown Techniques KW - Hep G2 Cells KW - Quercetin -- toxicity KW - Enzyme Activation -- drug effects KW - Molecular Conformation KW - Mutagens -- chemistry KW - Quercetin -- pharmacology KW - Plant Extracts -- pharmacology KW - Hepatocytes -- drug effects KW - DNA Topoisomerases, Type II -- genetics KW - DNA Topoisomerases, Type II -- metabolism KW - Plant Extracts -- toxicity KW - Plant Leaves -- chemistry KW - Hepatocytes -- physiology KW - Plant Extracts -- chemistry KW - Ginkgo biloba -- chemistry KW - DNA Topoisomerases, Type II -- chemistry KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718330937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Ginkgo+biloba+leaf+extract+induces+DNA+damage+by+inhibiting+topoisomerase+II+activity+in+human+hepatic+cells.&rft.au=Zhang%2C+Zhuhong%3BChen%2C+Si%3BMei%2C+Hu%3BXuan%2C+Jiekun%3BGuo%2C+Xiaoqing%3BCouch%2C+Letha%3BDobrovolsky%2C+Vasily+N%3BGuo%2C+Lei%3BMei%2C+Nan&rft.aulast=Zhang&rft.aufirst=Zhuhong&rft.date=2015-09-30&rft.volume=5&rft.issue=&rft.spage=14633&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep14633 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-19 N1 - Date created - 2015-09-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mutat Res. 2010 Feb;696(1):41-7 [20025993] Eur J Clin Pharmacol. 2010 May;66(5):503-9 [20186406] Toxicol Sci. 2010 Aug;116(2):488-97 [20507880] Curr Med Chem. 2012;19(31):5287-93 [22998568] Toxicol In Vitro. 2001 Jun;15(3):245-56 [11377097] Annu Rev Biochem. 2001;70:369-413 [11395412] J Pharm Pharmacol. 2002 May;54(5):661-9 [12005361] Hum Psychopharmacol. 2002 Aug;17(6):267-77 [12404671] Curr Top Med Chem. 2003;3(3):321-38 [12570766] Drugs R D. 2003;4(3):188-93 [12757407] Cancer Cell. 2003 May;3(5):421-9 [12781359] Pharmacol Ther. 2003 Aug;99(2):167-81 [12888111] Mutat Res. 1981 Mar;88(3):317-24 [7254225] Nat Prod Res. 2011 Feb;25(3):222-31 [20544499] Free Radic Biol Med. 2011 Oct 1;51(7):1406-10 [21745563] Toxicol Sci. 2011 Dec;124(2):388-99 [21908763] Nat Rev Mol Cell Biol. 2011 Dec;12(12):827-41 [22108601] Methods Mol Biol. 2012;817:231-50 [22147576] Eur J Clin Pharmacol. 2012 May;68(5):553-60 [22189672] Molecules. 2012;17(5):5255-68 [22565478] Toxicol Sci. 2012 Jun;127(2):582-91 [22387747] Neurology. 2012 Sep 18;79(12):1278-84 [22955125] Environ Mol Mutagen. 1994;24(4):245-61 [7851337] Biochemistry. 1992 Dec 8;31(48):12069-75 [1333791] Lancet Neurol. 2012 Oct;11(10):851-9 [22959217] Mutat Res. 1995 Jun;343(2-3):85-94 [7791812] Cancer Causes Control. 1996 Nov;7(6):581-90 [8932918] J Biol Chem. 1998 Mar 6;273(10):5858-68 [9488723] Mutat Res. 1998 May 25;400(1-2):271-8 [9685677] Biochem J. 2004 Dec 15;384(Pt 3):527-41 [15312049] Pharmacogenetics. 2004 Dec;14(12):841-50 [15608563] Rapid Commun Mass Spectrom. 2006;20(18):2753-60 [16921563] J Clin Pharmacol. 2006 Nov;46(11):1290-8 [17050793] Mutat Res. 2007 Oct 1;623(1-2):83-97 [17681352] Cell Biochem Biophys. 2007;49(1):29-36 [17873337] Food Chem Toxicol. 2007 Dec;45(12):2441-5 [17681658] J Nutr. 2008 Sep;138(9):1615-21 [18716159] Toxicology. 2008 Dec 30;254(3):192-8 [18840496] J Chromatogr A. 2009 Mar 13;1216(11):2002-32 [19195661] Natl Toxicol Program Tech Rep Ser. 2013 Mar;(578):1-183 [23652021] Arch Toxicol. 2013 Jun;87(6):1115-27 [23397584] Toxicol Lett. 2013 Jul 31;221(1):64-72 [23747414] Toxicol Sci. 2014 Feb;137(2):404-15 [24194395] Food Chem Toxicol. 2014 Mar;65:233-41 [24394490] Ann N Y Acad Sci. 2014 Mar;1310:98-110 [24495080] Toxicol Sci. 2014 Jun;139(2):338-49 [24595819] Toxicology. 2014 Aug 1;322:78-88 [24865413] J Biomol Screen. 2014 Oct;19(9):1246-54 [24980598] Int J Geriatr Psychiatry. 2014 Oct;29(10):1087-95 [24633934] Planta Med. 2010 Oct;76(15):1683-90 [20486074] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4790-5 [10758153] Toxicol Lett. 2000 Jul 27;116(1-2):7-16 [10906417] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep14633 ER - TY - JOUR T1 - Estrogenic activity data extraction and in silico prediction show the endocrine disruption potential of bisphenol A replacement compounds. AN - 1715661244; 26308263 AB - Bisphenol A (BPA) replacement compounds are released to the environment and cause widespread human exposure. However, a lack of thorough safety evaluations on the BPA replacement compounds has raised public concerns. We assessed the endocrine disruption potential of BPA replacement compounds in the market to assist their safety evaluations. A literature search was conducted to ascertain the BPA replacement compounds in use. Available experimental estrogenic activity data of these compounds were extracted from the Estrogenic Activity Database (EADB) to assess their estrogenic potential. An in silico model was developed to predict the estrogenic activity of compounds lacking experimental data. Molecular dynamics (MD) simulations were performed to understand the mechanisms by which the estrogenic compounds bind to and activate the estrogen receptor (ER). Forty-five BPA replacement compounds were identified in the literature. Seven were more estrogenic and five less estrogenic than BPA, while six were nonestrogenic in EADB. A two-tier in silico model was developed based on molecular docking to predict the estrogenic activity of the 27 compounds lacking data. Eleven were predicted as ER binders and 16 as nonbinders. MD simulations revealed hydrophobic contacts and hydrogen bonds as the main interactions between ER and the estrogenic compounds. JF - Chemical research in toxicology AU - Ng, Hui Wen AU - Shu, Mao AU - Luo, Heng AU - Ye, Hao AU - Ge, Weigong AU - Perkins, Roger AU - Tong, Weida AU - Hong, Huixiao AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration , 3900 NCTR Road, Jefferson, Arkansas 72079, United States. Y1 - 2015/09/21/ PY - 2015 DA - 2015 Sep 21 SP - 1784 EP - 1795 VL - 28 IS - 9 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Estrogens KW - Phenols KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Computer Simulation KW - Databases, Chemical KW - Molecular Dynamics Simulation KW - Endocrine Disruptors -- toxicity KW - Benzhydryl Compounds -- toxicity KW - Estrogens -- pharmacology KW - Phenols -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1715661244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=UVA+photoirradiation+of+benzo%5Ba%5Dpyrene+metabolites%3A+induction+of+cytotoxicity%2C+reactive+oxygen+species%2C+and+lipid+peroxidation.&rft.au=Xia%2C+Qingsu%3BChiang%2C+Hsiu-Mei%3BYin%2C+Jun-Jie%3BChen%2C+Shoujun%3BCai%2C+Lining%3BYu%2C+Hongtao%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2015-10-01&rft.volume=31&rft.issue=10&rft.spage=898&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=1477-0393&rft_id=info:doi/10.1177%2F0748233713484648 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-08 N1 - Date created - 2015-09-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00243 ER - TY - JOUR T1 - Alternative testing methods for skin sensitization: NMR spectroscopy for probing the reactivity and classification of potential skin sensitizers. AN - 1715660927; 26225548 AB - Evaluating consumer products for potentially harmful side effects of chemical ingredients is important for the protection of both the consumer and those involved in the manufacturing process. In order to assess the risk potential of chemicals, regulatory agencies have encouraged the development of several in silico, in vitro, and in chemico methods as alternatives to eliminate or minimize the use of animals. To add structural information to the existing in chemico methods, an NMR-based method is proposed for probing the reactivity and classification of the potential electrophiles (E) using a model thiol, DCYA, as a nucleophile. The major advantage of the NMR method is the quantitation of the actual adduct, DCYA-E. The degree of reaction is here provided as a direct measurement of adduct formation and/or electrophile depletion, in contrast to other in chemico assays, e.g., ADRA and DPRA, where the reactivity is inferred from the quantification of the test nucleophile depletion. Moreover, the developed NMR method should serve as a qualitative and quantitative tool in understanding the site of reaction and other structural information associated with test sensitizer. This is particularly valuable and advantageous over methods encouraged by regulatory agencies, which merely provide quantification of the reaction but lack any structural information. Several compounds with multiple reaction sites were successfully tested with the proposed NMR method. Otherwise, these compounds have proven to be a challenge to identify and classify using existing alternative methods. JF - Chemical research in toxicology AU - Chittiboyina, Amar G AU - Avonto, Cristina AU - Rua, Diego AU - Khan, Ikhlas A AD - The Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States. Y1 - 2015/09/21/ PY - 2015 DA - 2015 Sep 21 SP - 1704 EP - 1714 VL - 28 IS - 9 KW - Index Medicus KW - Animals KW - Skin -- drug effects KW - Proton Magnetic Resonance Spectroscopy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1715660927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Alternative+testing+methods+for+skin+sensitization%3A+NMR+spectroscopy+for+probing+the+reactivity+and+classification+of+potential+skin+sensitizers.&rft.au=Chittiboyina%2C+Amar+G%3BAvonto%2C+Cristina%3BRua%2C+Diego%3BKhan%2C+Ikhlas+A&rft.aulast=Chittiboyina&rft.aufirst=Amar&rft.date=2015-09-21&rft.volume=28&rft.issue=9&rft.spage=1704&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.5b00098 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-08 N1 - Date created - 2015-09-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00098 ER - TY - CPAPER T1 - Current US FDA Approaches to the Regulation and Approval of Novel Antibacterial Therapeutics T2 - 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2015) AN - 1697990232; 6353727 JF - 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2015) AU - Nambiar, Sumathi Y1 - 2015/09/17/ PY - 2015 DA - 2015 Sep 17 KW - FDA KW - Antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697990232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2015%29&rft.atitle=Current+US+FDA+Approaches+to+the+Regulation+and+Approval+of+Novel+Antibacterial+Therapeutics&rft.au=Nambiar%2C+Sumathi&rft.aulast=Nambiar&rft.aufirst=Sumathi&rft.date=2015-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={7A574A80-EAB1-4B50-B343-4695DF14907E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-30 N1 - Last updated - 2015-07-23 ER - TY - JOUR T1 - Urogenital Chlamydia trachomatis strain types, defined by high-resolution multilocus sequence typing, in relation to ethnicity and urogenital symptoms among a young screening population in Amsterdam, The Netherlands AN - 1827926997; PQ0003419399 AB - IntroductionPrevious studies found conflicting results regarding associations between urogenital Chlamydia trachomatis infections and ethnicity or urogenital symptoms among at-risk populations using either ompA-based genotyping or high-resolution multilocus sequence typing (MLST). This study applied high-resolution MLST on samples of individuals from a selected young urban screening population to assess the relationship of C. trachomatis strain types with ethnicity and self-reported urogenital symptoms. Demographic and sexual risk behaviour characteristics of the identified clusters were also analysed.MethodsWe selected C. trachomatis-positive samples from the Dutch Chlamydia Screening Implementation study among young individuals in Amsterdam, the Netherlands. All samples were typed using high-resolution MLST. Clusters were assigned using minimum spanning tree analysis and were combined with epidemiological data of the participants.ResultsWe obtained full MLST data for C. trachomatis-positive samples from 439 participants and detected nine ompA genovars. MLST analysis identified 175 sequence types and six large clusters; in one cluster, participants with Surinamese/Antillean ethnicity were over-represented (58.8%) and this cluster predominantly consisted of genovar I. In addition, we found one cluster with an over-representation of participants with Dutch ethnicity (90.0%) and which solely consisted of genovar G. No association was observed between C. trachomatis clusters and urogenital symptoms.ConclusionsWe found an association between urogenital C. trachomatis clusters and ethnicity among young screening participants in Amsterdam, the Netherlands. However, no association was found between C. trachomatis clusters and self-reported urogenital symptoms. JF - Sexually Transmitted Infections AU - Versteeg, Bart AU - Himschoot, Michelle AU - van den Broek, Ingrid V F AU - Bom, Reinier J M AU - Speksnijder, Arjen G C L AU - Schim van der Loeff, Maarten F AU - Bruisten, Sylvia M AD - Public Health Laboratory, Cluster Infectious Diseases, Public Health Service Amsterdam, , Amsterdam, The Netherlands Y1 - 2015/09/16/ PY - 2015 DA - 2015 Sep 16 SP - 415 EP - 422 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 91 IS - 6 SN - 1368-4973, 1368-4973 KW - Microbiology Abstracts B: Bacteriology KW - CHLAMYDIA TRACHOMATIS KW - CHLAMYDIA INFECTION KW - BACTERIAL TYPING KW - Demography KW - Data processing KW - Trees KW - Genotyping KW - Chlamydia trachomatis KW - Infection KW - Sexual behavior KW - Ethnic groups KW - multilocus sequence typing KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827926997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=Urogenital+Chlamydia+trachomatis+strain+types%2C+defined+by+high-resolution+multilocus+sequence+typing%2C+in+relation+to+ethnicity+and+urogenital+symptoms+among+a+young+screening+population+in+Amsterdam%2C+The+Netherlands&rft.au=Versteeg%2C+Bart%3BHimschoot%2C+Michelle%3Bvan+den+Broek%2C+Ingrid+V+F%3BBom%2C+Reinier+J+M%3BSpeksnijder%2C+Arjen+G+C+L%3BSchim+van+der+Loeff%2C+Maarten+F%3BBruisten%2C+Sylvia+M&rft.aulast=Versteeg&rft.aufirst=Bart&rft.date=2015-09-16&rft.volume=91&rft.issue=6&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/10.1136%2Fsextrans-2014-051790 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Demography; Data processing; Trees; Genotyping; Infection; Sexual behavior; Ethnic groups; multilocus sequence typing; Chlamydia trachomatis DO - http://dx.doi.org/10.1136/sextrans-2014-051790 ER - TY - JOUR T1 - Nonclinical evaluation of the potential for mast cell activation by an erythropoietin analog. AN - 1706577997; 26079829 AB - The erythropoietin analog peginesatide was withdrawn from marketing due to unexpected severe anaphylactic reactions associated with administration of the multi-use formulation. The adverse events occurred rapidly following the first ever administration of the drug with most affected patients becoming symptomatic in less than 30min. This is most consistent with an anaphylactoid reaction due to direct activation of mast cells. Laboratory evaluation was undertaken using rat peritoneal mast cells as the model system. Initial studies showed that high concentrations of the formulated drug as well as formulated vehicle alone could cause mast cell degranulation as measured by histamine release. The purified active drug was not able to cause histamine release whereas the vehicle filtrate and lab created drug vehicle were equally potent at causing histamine release. Individual formulations of vehicle leaving one component out showed that histamine release was due to phenol. Dose response studies with phenol showed a very sharp dose response curve that was similar in three buffer systems. Cellular analysis by flow cytometry showed that the histamine release was not due to cell death, and that changes in light scatter parameters consistent with degranulation were rapidly observed. Limited testing with primary human mast cells showed a similar dose response of histamine release with exposure to phenol. To provide in vivo confirmation, rats were injected with vehicle formulated with various concentrations of phenol via a jugular vein cannula. Significant release of histamine was detected in blood samples taken 2min after dosing at the highest concentrations tested. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Weaver, James L AU - Boyne, Michael AU - Pang, Eric AU - Chimalakonda, Krishna AU - Howard, Kristina E AD - Division of Applied Regulatory Science, OCP/OTS/CDER/FDA, Silver Spring, MD, USA. Electronic address: James.Weaver@fda.hhs.gov. ; Division of Pharmaceutical Analysis, OTR/OPQ/CDER/FDA, Silver Spring, MD, USA. Electronic address: mboyne@biotechlogic.com. ; Division of Applied Regulatory Science, OCP/OTS/CDER/FDA, Silver Spring, MD, USA. Electronic address: Eric.Pang@fda.hhs.gov. ; Division of Applied Regulatory Science, OCP/OTS/CDER/FDA, Silver Spring, MD, USA. Electronic address: Krishna.Chimalakonda@fda.hhs.gov. ; Division of Applied Regulatory Science, OCP/OTS/CDER/FDA, Silver Spring, MD, USA. Electronic address: Kristina.Howard@fda.hhs.gov. Y1 - 2015/09/15/ PY - 2015 DA - 2015 Sep 15 SP - 246 EP - 252 VL - 287 IS - 3 KW - Excipients KW - 0 KW - Hematinics KW - Peptides KW - peginesatide KW - Phenol KW - 339NCG44TV KW - Histamine KW - 820484N8I3 KW - Index Medicus KW - Mast cells KW - Anaphylactoid KW - Peginesatide KW - Animals KW - Rats, Sprague-Dawley KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Chemistry, Pharmaceutical KW - Cells, Cultured KW - Mice, Inbred NOD KW - Humans KW - Primary Cell Culture KW - Time Factors KW - Female KW - Risk Assessment KW - Hematinics -- toxicity KW - Histamine -- blood KW - Histamine -- metabolism KW - Excipients -- administration & dosage KW - Mast Cells -- drug effects KW - Cell Degranulation -- drug effects KW - Phenol -- toxicity KW - Hematinics -- chemistry KW - Excipients -- toxicity KW - Phenol -- chemistry KW - Mast Cells -- metabolism KW - Phenol -- administration & dosage KW - Excipients -- chemistry KW - Peptides -- chemistry KW - Peptides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1706577997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Nonclinical+evaluation+of+the+potential+for+mast+cell+activation+by+an+erythropoietin+analog.&rft.au=Weaver%2C+James+L%3BBoyne%2C+Michael%3BPang%2C+Eric%3BChimalakonda%2C+Krishna%3BHoward%2C+Kristina+E&rft.aulast=Weaver&rft.aufirst=James&rft.date=2015-09-15&rft.volume=287&rft.issue=3&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.06.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-16 N1 - Date created - 2015-08-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.06.009 ER - TY - JOUR T1 - Creation of a retrospective job-exposure matrix using surrogate measures of exposure for a cohort of US career firefighters from San Francisco, Chicago and Philadelphia AN - 1808704872; PQ0003419056 AB - ObjectivesTo construct a cohort-specific job-exposure matrix (JEM) using surrogate metrics of exposure for a cancer study on career firefighters from the Chicago, Philadelphia and San Francisco Fire Departments.MethodsDepartmental work history records, along with data on historical annual fire-runs and hours, were collected from 1950 to 2009 and coded into separate databases. These data were used to create a JEM based on standardised job titles and fire apparatus assignments using several surrogate exposure metrics to estimate firefighters' exposure to the combustion byproducts of fire. The metrics included duration of exposure (cumulative time with a standardised exposed job title and assignment), fire-runs (cumulative events of potential fire exposure) and time at fire (cumulative hours of potential fire exposure).ResultsThe JEM consisted of 2298 unique job titles alongside 16174 fire apparatus assignments from the three departments, which were collapsed into 15 standardised job titles and 15 standardised job assignments. Correlations were found between fire-runs and time at fires (Pearson coefficient=0.92), duration of exposure and time at fires (Pearson coefficient=0.85), and duration of exposure and fire-runs (Pearson coefficient=0.82). Total misclassification rates were found to be between 16-30% when using duration of employment as an exposure surrogate, which has been traditionally used in most epidemiological studies, compared with using the duration of exposure surrogate metric.ConclusionsThe constructed JEM successfully differentiated firefighters based on gradient levels of potential exposure to the combustion byproducts of fire using multiple surrogate exposure metrics. JF - Occupational and Environmental Medicine AU - Dahm, Matthew M AU - Bertke, Stephen AU - Allee, Steve AU - Daniels, Robert D AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/09/10/ PY - 2015 DA - 2015 Sep 10 SP - 670 EP - 677 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 72 IS - 9 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Firefighters KW - Job-Exposure Matrix KW - Dose-Response KW - USA, Illinois, Chicago KW - Historical account KW - Fires KW - Data processing KW - USA, Pennsylvania, Philadelphia KW - Byproducts KW - Careers KW - Employment KW - Cancer KW - Combustion KW - Databases KW - Firefighter services KW - INE, USA, California, San Francisco KW - Data bases KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808704872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Creation+of+a+retrospective+job-exposure+matrix+using+surrogate+measures+of+exposure+for+a+cohort+of+US+career+firefighters+from+San+Francisco%2C+Chicago+and+Philadelphia&rft.au=Dahm%2C+Matthew+M%3BBertke%2C+Stephen%3BAllee%2C+Steve%3BDaniels%2C+Robert+D&rft.aulast=Dahm&rft.aufirst=Matthew&rft.date=2015-09-10&rft.volume=72&rft.issue=9&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102790 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Databases; Fires; Data processing; Cancer; Combustion; Historical account; Byproducts; Firefighter services; Careers; Employment; Data bases; USA, Illinois, Chicago; USA, Pennsylvania, Philadelphia; INE, USA, California, San Francisco DO - http://dx.doi.org/10.1136/oemed-2014-102790 ER - TY - JOUR T1 - Platinum Nanoparticles: Efficient and Stable Catechol Oxidase Mimetics. AN - 1710983868; 26305170 AB - Although enzyme-like nanomaterials have been extensively investigated over the past decade, most research has focused on the peroxidase-like, catalase-like, or SOD-like activity of these nanomaterials. Identifying nanomaterials having oxidase-like activities has received less attention. In this study, we demonstrate that platinum nanoparticles (Pt NPs) exhibit catechol oxidase-like activity, oxidizing polyphenols into the corresponding o-quinones. Four unique approaches are employed to demonstrate the catechol oxidase-like activity exerted by Pt NPs. First, UV-vis spectroscopy is used to monitor the oxidation of polyphenols catalyzed by Pt NPs. Second, the oxidized products of polyphenols are identified by ultrahigh-performance liquid chromatography (UHPLC) separation followed by high-resolution mass spectrometry (HRMS) identification. Third, electron spin resonance (ESR) oximetry techniques are used to confirm the O2 consumption during the oxidation reaction. Fourth, the intermediate products of semiquinone radicals formed during the oxidation of polyphenols are determined by ESR using spin stabilization. These results indicate Pt NPs possess catechol oxidase-like activity. Because polyphenols and related bioactive substances have been explored as potent antioxidants that could be useful for the prevention of cancer and cardiovascular diseases, and Pt NPs have been widely used in the chemical industry and medical science, it is essential to understand the potential effects of Pt NPs for altering or influencing the antioxidant activity of polyphenols. JF - ACS applied materials & interfaces AU - Liu, Yi AU - Wu, Haohao AU - Chong, Yu AU - Wamer, Wayne G AU - Xia, Qingsu AU - Cai, Lining AU - Nie, Zhihong AU - Fu, Peter P AU - Yin, Jun-Jie AD - Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , College Park, Maryland 20740, United States. ; Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , College Park, Maryland 20740, United States. ; Biochemical Toxicology Division, National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson, Arkansas 72079, United States. ; Biotranex LLC , Monmouth Junction, New Jersey 08852, United States. ; Department of Chemistry and Biochemistry, University of Maryland , College Park, Maryland 20742, United States. Y1 - 2015/09/09/ PY - 2015 DA - 2015 Sep 09 SP - 19709 EP - 19717 VL - 7 IS - 35 KW - Caffeic Acids KW - 0 KW - Polyphenols KW - Quinones KW - Platinum KW - 49DFR088MY KW - Catechin KW - 8R1V1STN48 KW - Quercetin KW - 9IKM0I5T1E KW - Catechol Oxidase KW - EC 1.10.3.1 KW - Monophenol Monooxygenase KW - EC 1.14.18.1 KW - Oxygen KW - S88TT14065 KW - caffeic acid KW - U2S3A33KVM KW - Index Medicus KW - oxidation of polyphenols KW - enzyme mimetics KW - platinum nanoparticles KW - catechol oxidase-like activity KW - heterogeneous catalysts KW - Caffeic Acids -- chemistry KW - Mass Spectrometry KW - Monophenol Monooxygenase -- metabolism KW - Quinones -- chemistry KW - Catechol Oxidase -- chemistry KW - Quinones -- analysis KW - Monophenol Monooxygenase -- chemistry KW - Quercetin -- chemistry KW - Catechol Oxidase -- metabolism KW - Catechin -- chemistry KW - Chromatography, High Pressure Liquid KW - Oxidation-Reduction KW - Electron Spin Resonance Spectroscopy KW - Oxygen -- chemistry KW - Polyphenols -- analysis KW - Polyphenols -- chemistry KW - Catalysis KW - Platinum -- chemistry KW - Metal Nanoparticles -- chemistry KW - Biomimetic Materials -- metabolism KW - Biomimetic Materials -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1710983868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+applied+materials+%26+interfaces&rft.atitle=Platinum+Nanoparticles%3A+Efficient+and+Stable+Catechol+Oxidase+Mimetics.&rft.au=Bui-Nguyen%2C+Tri+M%3BBaer%2C+Christine+E%3BLewis%2C+John+A%3BYang%2C+Dongren%3BLein%2C+Pamela+J%3BJackson%2C+David+A&rft.aulast=Bui-Nguyen&rft.aufirst=Tri&rft.date=2015-10-24&rft.volume=16&rft.issue=&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2Fs12864-015-1941-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-13 N1 - Date created - 2015-09-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acsami.5b05180 ER - TY - JOUR T1 - Deciphering the underlying mechanisms of oxidation-state dependent cytotoxicity of graphene oxide on mammalian cells. AN - 1693711121; 26047786 AB - The promising broad applications of graphene oxide (GO) derivatives in biomedicine have raised concerns about their safety on biological organisms. However, correlations between the physicochemical properties, especially oxidation degree of GOs and their toxicity, and the underlying mechanisms are not well understood. Herein, we evaluated the cytotoxicity of three GO samples with various oxidation degrees on mouse embryo fibroblasts (MEFs). Three samples can be internalized by MEFs observed via transmission electron microscopy (TEM), and were well tolerant by MEFs at lower doses (below 25μg/ml) but significantly toxic at 50 and 100μg/ml via Cytell Imaging System. More importantly, as the oxidation degree decreased, GO derivatives led to a higher degree of cytotoxicity and apoptosis. Meanwhile, three GOs stimulated dramatic enhancement in reactive oxygen species (ROS) production in MEFs, where the less oxidized GO produced a higher level of ROS, suggesting the major role of oxidative stress in the oxidation-degree dependent toxicity of GOs. Results from electron spin resonance (ESR) spectrometry showed a strong association of the lower oxidation degree of GOs with their stronger indirect oxidative damage through facilitating H2O2 decomposition into OH and higher direct oxidative abilities on cells. The theoretical simulation revealed the key contributions of carboxyl groups and aromatic domain size of nanosheets to varying the energy barrier of H2O2 decomposition reaction. These systematic explorations in the chemical mechanisms unravel the key physicochemical properties that would lead to the diverse toxic profiles of the GO nanosheets with different oxygenation levels, and offer us new clues in the molecular design of carbon nanomaterials for their safe applications in biomedicine. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Zhang, Wendi AU - Yan, Liang AU - Li, Meng AU - Zhao, Ruisheng AU - Yang, Xiao AU - Ji, Tianjiao AU - Gu, Zhanjun AU - Yin, Jun-Jie AU - Gao, Xingfa AU - Nie, Guangjun AD - Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. ; Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. ; Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. ; Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. Electronic address: niegj@nanoctr.cn. Y1 - 2015/09/02/ PY - 2015 DA - 2015 Sep 02 SP - 61 EP - 71 VL - 237 IS - 2 KW - Oxides KW - 0 KW - Reactive Oxygen Species KW - Graphite KW - 7782-42-5 KW - Index Medicus KW - Cytotoxicity KW - Reactive oxygen species (ROS) KW - Apoptosis KW - Graphene oxide (GO) KW - Electron spin resonance (ESR) spectrometry KW - Oxidation-Reduction KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Electron Spin Resonance Spectroscopy KW - Apoptosis -- drug effects KW - Oxides -- pharmacology KW - Mice KW - Graphite -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1693711121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Deciphering+the+underlying+mechanisms+of+oxidation-state+dependent+cytotoxicity+of+graphene+oxide+on+mammalian+cells.&rft.au=Zhang%2C+Wendi%3BYan%2C+Liang%3BLi%2C+Meng%3BZhao%2C+Ruisheng%3BYang%2C+Xiao%3BJi%2C+Tianjiao%3BGu%2C+Zhanjun%3BYin%2C+Jun-Jie%3BGao%2C+Xingfa%3BNie%2C+Guangjun&rft.aulast=Zhang&rft.aufirst=Wendi&rft.date=2015-09-02&rft.volume=237&rft.issue=2&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2015.05.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-15 N1 - Date created - 2015-07-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2015.05.021 ER - TY - RPRT T1 - Which Early Care and Education Centers Participate in Head Start or Public Pre-Kindergarten? National Survey of Early Care & Education. Technical Report. OPRE Report 2015-92a AN - 1826518484; ED564119 AB - This report draws on newly available data from the National Survey of Early Care and Education (NSECE) to describe early care and education (ECE) centers that participate in two prominent publicly-funded ECE initiatives: Head Start and publicly-funded pre-kindergarten. Although a great deal is known about Head Start programs, and there are sources of information about Public Pre-K, there has been no available data source that documents how centers participating in these publicly-funded initiatives fit within the full spectrum of center-based ECE. This report identifies the number of centers nationally that had enrollment funded by Head Start or Public Pre-K funds in 2012, and describes some characteristics of these programs. In the NSECE data, a "center" refers to all ECE services to children under age 13 years provided by one organization in a single location. An accompanying technical supplement provides details on the methodology for identifying programs as participating in these two ECE initiatives, and explains some issues pertaining to analyses of NSECE data regarding programs' participation in Head Start and Public Pre-K. [For "Identifying Head Start and Public Pre-K Participation in NSECE Data on Center-Based ECE Programs. NSECE Technical Report Supplement. OPRE Report 2015-92b," see ED564118.] Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 8 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Financial Support KW - Geographic Location KW - Institutional Characteristics KW - Educational Finance KW - National Surveys KW - Public Schools KW - Enrollment KW - Early Intervention KW - Poverty Areas KW - Child Care Centers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826518484?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Identifying Head Start and Public Pre-K Participation in NSECE Data on Center-Based ECE Programs. NSECE Technical Report Supplement. OPRE Report 2015-92b AN - 1826516946; ED564118 AB - The analyses presented in the Technical Report, "Which Centers Participate in Head Start or Public Pre-Kindergarten" characterize centers that have at least one child whose enrollment is funded through Head Start or Public Pre-K funds. This supplement to the technical report provides interested readers with technical details of the analyses, including additional information about tabulations and definitions used, as well as discussion of features of the data that affect how additional analyses might be undertaken. [For "Which Early Care and Education Centers Participate in Head Start or Public Pre-Kindergarten? National Survey of Early Care & Education. Technical Report. OPRE Report 2015-92a," see ED564119.] AU - Goerge, Robert AU - Datta, Rupa A. AU - Xia, Kanru AU - Witte, Ann D. AU - Gennetian, Lisa A. AU - Milesi, Carolina AU - Brandon, Richard AU - Guzman, Lina AU - Zanoni, Wladimir Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 8 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Financial Support KW - Geographic Location KW - Institutional Characteristics KW - Public Schools KW - Research Methodology KW - Educational Finance KW - Enrollment KW - Early Intervention KW - Child Care Centers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826516946?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Hemoglobin assay for validation and quality control of medical device reprocessing AN - 1746891975; PQ0001974740 AB - Hemoglobin (Hb) is an important analyte in medicine, forensics, and research. One area of crucial need for real-world Hb quantitation is the validation and quality control (QC) of reprocessed medical device cleaning. Here, we show how a microplate reader and colorimetric blood test strips can be used to quantitate nanogram (ng) quantities of Hb in a 1-min assay. The assay had a linear range of 0-50 ng (0-370 ng on a log scale) for Hb, with a limit of detection (LOD) of 3.3 ng, which was 500-fold more sensitive than the micro-BCA reagent (LOD=1.6 mu g) and on the same order of magnitude as detection of labeled Hb with fluorescence (LOD=1.9 ng). For validation of medical device cleaning, the assay was specific for Hb in the presence of artificial test soil and was unaffected by interferences from common cleaning reagents at 10 ppm. Lubricant and sodium dodecyl sulfate did not significantly affect the assay at 10 ppm but affected the assay at 1 % g/g. The method showed 100 % recovery of hemoglobin in extracted soils, with extraction from silicone having the greatest variability in recovery, while Teflon and stainless steel had <10 % RSD. The assay makes it possible for medical device companies and health-care providers to obtain crucially needed information on the cleanliness of reused devices. JF - Analytical and Bioanalytical Chemistry AU - Frey, Justin AU - Guan, Allan AU - Li, Zhenyu AU - Turtil, Steven AU - Phillips, KScott AD - Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry and Materials Science, United States Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993, USA, kenneth.phillips@fda.hhs.gov PY - 2015 SP - 6885 EP - 6889 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 407 IS - 22 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Testing Procedures KW - Reagents KW - Variability KW - Fluorescence KW - Cleaning KW - Sodium KW - Blood KW - Assay KW - Quality Control KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746891975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Hemoglobin+assay+for+validation+and+quality+control+of+medical+device+reprocessing&rft.au=Frey%2C+Justin%3BGuan%2C+Allan%3BLi%2C+Zhenyu%3BTurtil%2C+Steven%3BPhillips%2C+KScott&rft.aulast=Frey&rft.aufirst=Justin&rft.date=2015-09-01&rft.volume=407&rft.issue=22&rft.spage=6885&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-015-8856-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 16 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Sodium; Testing Procedures; Blood; Reagents; Variability; Fluorescence; Assay; Quality Control; Cleaning DO - http://dx.doi.org/10.1007/s00216-015-8856-2 ER - TY - JOUR T1 - Development and validation of a new transgenic hairless albino mouse as a mutational model for potential assessment of photocarcinogenicity AN - 1746883167; PQ0002319261 AB - Short-term phototoxicity testing is useful in selecting test agents for the longer and more expensive photocarcinogenesis safety tests; however, no validated short-term tests have been proven reliable in predicting the outcome of a photocarcinogenesis safety test. A transgenic, hairless, albino (THA) mouse model was developed that carries the gpt and red/gam [Spi-] genes from the gpt delta mouse background and the phenotypes from the SKH-1 mouse background to use as a short-term test in lieu of photocarcinogenesis safety tests. Validation of the THA mouse model was confirmed by exposing groups of male mice to sub-erythemal doses of ultraviolet B (UVB) irradiation for three consecutive days emitted from calibrated overhead, Kodacel-filtered fluorescent lamps and measuring the mutant frequencies (MFs) in the gpt and red/gam (Spi-) genes and types of mutations in the gpt gene. The doses or irradiation were monitored with broad-spectrum dosimeters that were calibrated to a NIST-traceable standard and cumulative CIE-weighted doses were 20.55 and 41.0mJ/cm2 (effective). Mice were sacrificed 14 days after the final UVB exposure and MFs in both the gpt and red/gam genes were evaluated in the epidermis. The exposure of mice to UVB induced significant ten- to twelve-fold increases in the gpt MF and three- to five-fold increases in the Spi- MF over their respective background MF, 26 plus or minus 310-6 and 9 plus or minus 110-6. The gpt mutation spectra were significantly different between that of the UVB-irradiated and that of non-irradiated mice although the mutation spectra of both groups were dominated by C arrow right T transitions (84% and 66%). In mice exposed to UVB, the C arrow right T transitions occurred almost exclusively at dipyrimidine sites (92%), whereas in non-irradiated control mice, the C arrow right T transitions occurred at CpG sites (86%). These results suggest that the newly developed THA mice are a useful and reliable model for testing UVB-induced mutagenicity in skin tissue. The application of this model for short-term prediction of solar-induced skin carcinogenicity is presently under investigation. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Manjanatha, Mugimane G AU - Shelton, Sharon D AU - Chen, Ying AU - Gaddameedhi, Shobhan AU - Howard, Paul C AU - Boudreau, Mary D AD - National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, USFDA, Jefferson, AR, United States Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 42 EP - 52 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 791 SN - 1383-5718, 1383-5718 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Toxicology Abstracts KW - Transgenic Hairless albino mouse KW - gpt-Delta mouse KW - Spi- selection assay KW - Mutant frequency KW - Mutation frequency KW - Mutagenicity KW - Skin KW - Animal models KW - CpG islands KW - Mutagenesis KW - Phototoxicity KW - Epidermis KW - beta Radiation KW - U.V. radiation KW - Carcinogenicity KW - Hairless KW - Mutation KW - X 24390:Radioactive Materials KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746883167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Development+and+validation+of+a+new+transgenic+hairless+albino+mouse+as+a+mutational+model+for+potential+assessment+of+photocarcinogenicity&rft.au=Manjanatha%2C+Mugimane+G%3BShelton%2C+Sharon+D%3BChen%2C+Ying%3BGaddameedhi%2C+Shobhan%3BHoward%2C+Paul+C%3BBoudreau%2C+Mary+D&rft.aulast=Manjanatha&rft.aufirst=Mugimane&rft.date=2015-09-01&rft.volume=791&rft.issue=&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2015.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Mutagenicity; Skin; Animal models; Mutant frequency; CpG islands; Mutagenesis; Phototoxicity; Epidermis; beta Radiation; U.V. radiation; Carcinogenicity; Hairless; Mutation DO - http://dx.doi.org/10.1016/j.mrgentox.2015.08.001 ER - TY - JOUR T1 - Potential explosion hazard of carbonaceous nanoparticles: Explosion parameters of selected materials AN - 1732827379; PQ0002231321 AB - Following a previous explosion screening study, we have conducted concentration and ignition energy scans on several carbonaceous nanopowders: fullerene, SWCNT, carbon black, MWCNT, graphene, CNF, and graphite. We have measured minimum explosive concentration (MEC), minimum ignition energy (MIE), and minimum ignition temperature (MITcloud) for these materials. The nanocarbons exhibit MEC ~101-102 g/m3, comparable to the MEC for coals and for fine particle carbon blacks and graphites. The nanocarbons are confirmed mainly to be in the St-1 explosion class, with fullerene, at K St ~200bar-m/s, borderline St-1/St-2. We estimate MIE~102-103 J, an order of magnitude higher than the MIE for coals but an order of magnitude lower than the MIE for fine particle graphites. While the explosion severity of the nanocarbons is comparable to that of the coals, their explosion susceptibility (ease of ignition) is significantly less (i.e., the nanocarbons have higher MIEs than do the coals); by contrast, the nanocarbons exhibit similar explosion severity to the graphites but enhanced explosion susceptibility (i.e., the nanocarbons have lower MIEs than do the graphites). MITcloud >550 degree C, comparable to that of the coals and carbon blacks. JF - Journal of Hazardous Materials AU - Turkevich, Leonid A AU - Dastidar, Ashok G AU - Hachmeister, Zachary AU - Lim, Michael AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 1090 Tusculum Avenue, MS-R7, Cincinnati, OH 45226, USA Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 97 EP - 103 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 295 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts; Environment Abstracts KW - Explosion hazard KW - Dust KW - Carbon KW - Nanoparticle KW - Nanomaterials KW - Temperature effects KW - Black carbon KW - Graphite KW - Temperature KW - Particulates KW - Coal KW - Explosions KW - Hazards KW - Fullerenes KW - Energy KW - Explosives KW - nanoparticles KW - X 24350:Industrial Chemicals KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732827379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Potential+explosion+hazard+of+carbonaceous+nanoparticles%3A+Explosion+parameters+of+selected+materials&rft.au=Turkevich%2C+Leonid+A%3BDastidar%2C+Ashok+G%3BHachmeister%2C+Zachary%3BLim%2C+Michael&rft.aulast=Turkevich&rft.aufirst=Leonid&rft.date=2015-09-01&rft.volume=295&rft.issue=&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2015.03.069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Temperature effects; Carbon; Graphite; Fullerenes; Energy; Explosives; Coal; nanoparticles; Hazards; Black carbon; Temperature; Particulates; Explosions DO - http://dx.doi.org/10.1016/j.jhazmat.2015.03.069 ER - TY - JOUR T1 - Job strain and changes in the body mass index among working women: a prospective study AN - 1732813188; PQ0002109948 AB - Objective: The relationship between job strain and weight gain has been unclear, especially for women. Using data from over 52 000 working women, we compare the association between change in job strain and change in body mass index (BMI) across different levels of baseline BMI.Subjects/ Methods: We used data from participants in the Nurses' Health Study II (n=52 656, mean age=38.4 years), an ongoing prospective cohort study. Using linear regression, we modeled the change in BMI over 4 years as a function of the change in job strain, baseline BMI and the interaction between the two. Change in job strain was characterized in four categories combining baseline and follow-up levels as follows: consistently low strain (low at both points), decreased strain (high strain at baseline only), increased strain (high strain at follow-up only) and consistently high strain (high at both points). Age, race/ethnicity, pregnancy history, job types and health behaviors at baseline were controlled for in the model. Results: In adjusted models, women who reported high job strain at least once during the 4-year period had a greater increase in BMI ( Delta BMI=0.06-0.12, P<0.05) compared with those who never reported high job strain. The association between the change in job strain exposure and the change in BMI depended on the baseline BMI level (P=0.015 for the interaction): the greater the baseline BMI, the greater the BMI gain associated with consistently high job strain. The BMI gain associated with increased or decreased job strain was uniform across the range of baseline BMI. Conclusions: Women with higher BMI may be more vulnerable to BMI gain when exposed to constant work stress. Future research focusing on mediating mechanisms between job strain and BMI change should explore the possibility of differential responses to job strain by initial BMI. JF - International Journal of Obesity AU - Fujishiro, K AU - Lawson, C C AU - Hibert, E L AU - Chavarro, J E AU - Rich-Edwards, J W AD - Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH, USA PY - 2015 SP - 1395 EP - 1400 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 39 IS - 9 SN - 0307-0565, 0307-0565 KW - Physical Education Index; Health & Safety Science Abstracts KW - Historical account KW - Obesity KW - Age KW - Body mass KW - Women KW - Stress KW - Health KW - Strains KW - Medical personnel KW - Pregnancy KW - Apparel KW - Behavior KW - Body weight KW - Weight KW - Nursing KW - Females KW - Vulnerability KW - Ethnic groups KW - Occupational health KW - H 1000:Occupational Safety and Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732813188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Job+strain+and+changes+in+the+body+mass+index+among+working+women%3A+a+prospective+study&rft.au=Fujishiro%2C+K%3BLawson%2C+C+C%3BHibert%2C+E+L%3BChavarro%2C+J+E%3BRich-Edwards%2C+J+W&rft.aulast=Fujishiro&rft.aufirst=K&rft.date=2015-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Obesity; Weight; Body mass; Women; Stress; Health; Strains; Apparel; Historical account; Age; Medical personnel; Pregnancy; Body weight; Behavior; Nursing; Vulnerability; Females; Ethnic groups; Occupational health DO - http://dx.doi.org/10.1038/ijo.2015.91 ER - TY - JOUR T1 - Colonisation of dentures by Staphylococcus aureus and MRSA in out-patient and in-patient populations AN - 1722181398; PQ0001974677 AB - Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen, and colonisation with this organism can result in localised or systemic infections which may be fatal. One hundred in-patients admitted to a London teaching hospital and 100 out-patients attending prosthetic dentistry clinics were recruited into this study. Of the 100 out-patients, 27 % harboured S. aureus on their dentures, compared to 33 % of in-patients. Only one out-patient had MRSA colonising their dentures whereas 12 % of the in-patients harboured MRSA. The median total bacterial count of the denture plaque samples was 6.210 super(7) cfu/sample and 6.910 super(7) cfu/sample for the out-patient and in-patient populations, respectively. In most instances, where present, S. aureus comprised less than 1 % of the total viable denture microbiota. Phage typing demonstrated that EMRSA-15 and non-typeable strains were harboured on dentures. The results of this study have revealed that dentures are a potential reservoir of MRSA and so account should be taken of these findings when planning decontamination procedures for elimination of this pathogen. JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Lewis, N AU - Parmar, N AU - Hussain, Z AU - Baker, G AU - Green, I AU - Howlett, J AU - Kearns, A AU - Cookson, B AU - McDonald, A AU - Wilson, M AU - Ready, D AD - Eastman Dental Hospital, UCLH NHS Foundation Trust, 256 Gray's Inn Road, London, WC1X 8LD, UK, derren.ready@phe.gov.uk Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 1823 EP - 1826 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 34 IS - 9 SN - 0934-9723, 0934-9723 KW - Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - Dentures KW - Disseminated infection KW - Decontamination KW - Pathogens KW - Dentistry KW - Phage typing KW - Colony-forming cells KW - Plaques KW - Staphylococcus aureus KW - Hospitals KW - Prosthetics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722181398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=Colonisation+of+dentures+by+Staphylococcus+aureus+and+MRSA+in+out-patient+and+in-patient+populations&rft.au=Lewis%2C+N%3BParmar%2C+N%3BHussain%2C+Z%3BBaker%2C+G%3BGreen%2C+I%3BHowlett%2C+J%3BKearns%2C+A%3BCookson%2C+B%3BMcDonald%2C+A%3BWilson%2C+M%3BReady%2C+D&rft.aulast=Lewis&rft.aufirst=N&rft.date=2015-09-01&rft.volume=34&rft.issue=9&rft.spage=1823&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-015-2418-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 13 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Phage typing; Colony-forming cells; Drug resistance; Disseminated infection; Dentures; Decontamination; Plaques; Dentistry; Pathogens; Prosthetics; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1007/s10096-015-2418-6 ER - TY - JOUR T1 - On the outskirts of national health reform: a comparative assessment of health insurance and access to care in Puerto Rico and the United States AN - 1721357986; 4712142 AB - Policy Points:Puerto Rico is the United States' largest territory, home to nearly 4 million American citizens, yet it has remained largely on the outskirts of US health policy, including the Affordable Care Act (ACA).We analyzed national survey data from 2011 to 2012 and found that despite its far poorer population, Puerto Rico outperforms the mainland United States on several measures of health care coverage and access to care.While the ACA significantly increases federal resources in Puerto Rico, ongoing federal restrictions on Medicaid funding and premium tax credits in Puerto Rico pose substantial health policy challenges in the territory. Puerto Rico is the United States' largest territory, home to nearly 4 million American citizens. Yet it has remained largely on the outskirts of US health policy, including the Affordable Care Act (ACA). This article presents an overview of Puerto Rico's health care system and a comparative analysis of coverage and access to care in Puerto Rico and the mainland United States. We analyzed 2011-2012 data from the Behavioral Risk Factor Surveillance System, and 2012 data from the American Community Survey and its counterpart, the Puerto Rico Community Survey. Among adults 18 and older, we examined health insurance coverage; access measures, such as having a usual source of care and cost-related delays in care; self-reported health; and the receipt of recommended preventive services, such as cancer screening and glucose testing. We used multivariate regression models to compare Puerto Rico and the mainland United States, adjusted for age, income, race/ethnicity, and other demographic variables. Uninsured rates were significantly lower in Puerto Rico (unadjusted 7.4% versus 15.0%, adjusted difference: −12.0%, p < 0.001). Medicaid was far more common in Puerto Rico. Puerto Rican residents were more likely than those in the mainland United States to have a usual source of care and to have had a checkup within the past year, and fewer experienced cost-related delays in care. Screening rates for diabetes, mammograms, and Pap smears were comparable or better in Puerto Rico, while colonoscopy rates were lower. Self-reported health was slightly worse, but obesity and smoking rates were lower. Despite its far poorer population, Puerto Rico outperforms the mainland United States on several measures of coverage and access. Congressional policies capping federal Medicaid funds to the territory, however, have contributed to major budgetary challenges. While the ACA has significantly increased federal resources in Puerto Rico, ongoing restrictions on Medicaid funding and premium tax credits are posing substantial health policy challenges in the territory. Reprinted by permission of Blackwell Publishers JF - Milbank quarterly AU - Portela, Maria AU - Sommers, Benjamin D AD - Harvard University ; US Department of Health and Human Services Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 584 EP - 608 VL - 93 IS - 3 SN - 0887-378X, 0887-378X KW - Political Science KW - Puerto Rico KW - Health care KW - Regression analysis KW - Health insurance KW - Health policy KW - U.S.A. KW - Health services KW - Tax credits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1721357986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Milbank+quarterly&rft.atitle=On+the+outskirts+of+national+health+reform%3A+a+comparative+assessment+of+health+insurance+and+access+to+care+in+Puerto+Rico+and+the+United+States&rft.au=Portela%2C+Maria%3BSommers%2C+Benjamin+D&rft.aulast=Portela&rft.aufirst=Maria&rft.date=2015-09-01&rft.volume=93&rft.issue=3&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=Milbank+quarterly&rft.issn=0887378X&rft_id=info:doi/10.1111%2F1468-0009.12138 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-10-12 N1 - Last updated - 2015-10-12 N1 - SubjectsTermNotLitGenreText - 5784 6592 4957 11923 11949 13521; 12537 2992; 5788 11888 10472; 10739 12228 10919; 5775 13521; 5792 10484; 337 77 14; 433 293 14 DO - http://dx.doi.org/10.1111/1468-0009.12138 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF CIMSTAR 3800 IN F344/NTac RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF CIMSTAR 3800 IN WISTAR HAN [Crl:WI (Han)] RATS AND B6C3F1/N MICE (INHALATION STUDIES) AN - 1719237987 AB - CIMSTAR 3800 is a metalworking fluid used as a lubricant and for cooling during the machining and grinding of aluminum and steel. Exposure to CIMSTAR 3800 vapors occurs in a variety of metalworking occupations. We exposed groups of 50 male and female rats and mice to atmospheres containing aerosols of 10, 30, or 100 mg of CIMSTAR 3800 per cubic meter of air. Similar groups of animals exposed to clean air in the same type of inhalation chambers served as the control groups. Animals were exposed six hours per day, five days per week for two years. Tissues from more than 40 sites were examined for every animal. All groups of male and female rats and mice exposed to CIMSTAR 3800 had increased incidences of lesions of the respiratory tract, including metaplasia of the larynx and hyperplasia of the lung in male and female rats and mice, hyperplasia of tissues of the nose in male and females rats, and metaplasia of tissues of the nose in male and female mice. There were increased incidences of tumors of the thyroid gland and lung in female mice and marginally increased incidences of tumors of the prostate gland in male rats and of tumors of the skin and uterus in female rats. We conclude that exposure to aerosols of CIMSTAR 3800 caused tumors of the thyroid gland and lung in female mice and may have been associated with tumors of the prostate gland in male rats and of the skin and uterus in female rats. A spectrum of nonneoplastic lesions in the respiratory tract (nose, larynx, and lung) of male and female rats and mice were caused by CIMSTAR 3800. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 0_1,0_2,6 EP - 17,19-87,89-131,133-145,147-172 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Toxicology KW - Rodents KW - Metalworking industry KW - Human exposure KW - Tumors KW - Lubricants & lubrication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1719237987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+CIMSTAR+3800+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+CIMSTAR+3800+IN+WISTAR+HAN+%5BCrl%3AWI+%28Han%29%5D+RATS+AND+B6C3F1%2FN+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-09-01&rft.volume=&rft.issue=586&rft.spage=0_1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2015 N1 - Document feature - Tables; Graphs; Illustrations; References N1 - Last updated - 2015-10-06 ER - TY - RPRT T1 - Table of contents AN - 1719237823 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1719237823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-09-01&rft.volume=&rft.issue=586&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2015 N1 - Last updated - 2015-10-06 ER - TY - JOUR T1 - Nonclinical aspects of venous thrombosis in pregnancy. AN - 1718077620; 26404176 AB - Pregnancy is a hypercoagulable state which carries an excess risk of maternal venous thrombosis. Endothelial injury, alterations in blood flow and activation of the coagulation pathway are proposed to contribute to the hypercoagulability. The risk for thrombosis may be accentuated by certain drugs and device implants that directly or indirectly affect the coagulation pathway. To help ensure that these interventions do not result in adverse maternal or fetal outcomes during pregnancy, gravid experimental animals can be exposed to such treatments at various stages of gestation and over a dosage range that would identify hazards and inform risk assessment. Circulating soluble biomarkers can also be evaluated for enhancing the assessment of any increased risk of venous thrombosis during pregnancy. In addition to traditional in vivo animal testing, efforts are under way to incorporate reliable non-animal methods in the assessment of embryofetal toxicity and thrombogenic effects. This review summarizes hemostatic balance during pregnancy in animal species, embryofetal development, biomarkers of venous thrombosis, and alterations caused by drug-induced venous thrombosis. © 2015 Wiley Periodicals, Inc. JF - Birth defects research. Part C, Embryo today : reviews AU - Struble, Evi AU - Harrouk, Wafa AU - DeFelice, Albert AU - Tesfamariam, Belay AD - Division of Hematology Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. ; Division of Nonprescription Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. ; Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 190 EP - 200 VL - 105 IS - 3 KW - Biomarkers KW - 0 KW - Index Medicus KW - nonclinical evaluation KW - pregnancy KW - embryofetal toxicity assessment KW - drugs/biologics KW - venous thrombosis KW - biomarkers KW - Embryonic Development KW - Venous Thrombosis -- blood KW - Blood Coagulation KW - Animals KW - Venous Thrombosis -- physiopathology KW - Humans KW - Hemostasis KW - Fetal Development KW - Biomarkers -- blood KW - Female KW - Pregnancy KW - Pregnancy Complications, Hematologic -- blood KW - Thrombosis -- blood KW - Pregnancy Complications, Hematologic -- physiopathology KW - Thrombosis -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718077620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.atitle=Nonclinical+aspects+of+venous+thrombosis+in+pregnancy.&rft.au=Struble%2C+Evi%3BHarrouk%2C+Wafa%3BDeFelice%2C+Albert%3BTesfamariam%2C+Belay&rft.aulast=Struble&rft.aufirst=Evi&rft.date=2015-09-01&rft.volume=105&rft.issue=3&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.issn=1542-9768&rft_id=info:doi/10.1002%2Fbdrc.21111 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-25 N1 - Date created - 2015-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdrc.21111 ER - TY - JOUR T1 - The Diplomate in Safety Pharmacology (DSP) certification scheme. AN - 1717484836; 25959882 AB - As with other professional disciplines there is a growing need from within industry as well as global regulatory authorities for implementation of a certification process in order to assure that appropriate expertise is developed and quality standards are identified for professionals involved in the practice of Safety Pharmacology (SP). In order to meet this need, the Safety Pharmacology Society (SPS) has developed the Diplomate in Safety Pharmacology (DSP) certification process. There are many benefits to certification including authentication of the discipline within the overall pharmaceutical community and with regulatory authorities. It also encourages participation in SPS activities by other professionals (toxicologists, clinicians, academics) who wish to broaden their professional expertise. It provides an opportunity for candidates to strengthen their fundamental scientific knowledge, and stimulates the sharing of data, methods and model development in the form of publications and presentations on relevant topics in SP. Accreditation in SP occurs after candidates successfully complete a written certification examination conducted at the annual SPS meeting. The DSP exam consists primarily of material pertinent to the conduct of SP vital function core battery studies (i.e., cardiovascular, respiratory and central nervous systems), supplemental SP studies (i.e., renal/urinary, gastrointestinal, immunology, and hematology), Regulatory Guidelines (ICH Guidelines) as well as relevant cross-functional knowledge (e.g., physiology, pharmacology, toxicology, biochemistry, pathology, pharmacokinetics, dosing formulation, analytical methods, and statistics). Maintenance of the DSP certification results from the accrual of credits which are gained from a range of educational and scientific contributions. Eligibility requirements include a combination of at least a bachelor degree in science and two years of relevant professional SP experience and one poster presentation on a SP topic as first author at a recognized major scientific meeting. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Journal of pharmacological and toxicological methods AU - Authier, Simon AU - Curtis, Michael J AU - Soloviev, Maxim AU - Redfern, Will S AU - Kallman, Mary Jeanne AU - Hamlin, Robert L AU - Leishman, Derek J AU - Valentin, Jean-Pierre AU - Koerner, John E AU - Vargas, Hugo M AU - Botchway, Alfred AU - Correll, Krystle AU - Pugsley, Michael K AD - CiToxLAB North America, 445 Armand-Frappier Boul., Laval, QC H7V 4B3, Canada; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA. Electronic address: AUTHIERS@ca.citoxlab.com. ; Cardiovascular Division, Faculty of Life Sciences & Medicine, Rayne Institutez, King's College London, London SE17EH, UK. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Incyte Corporation, 1801 Augustine Cut-Off Wilmington, DE 19803, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; AstraZeneca R&D, Alderley Park, Cheshire SK10 4TG, UK. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; COVANCE Laboratories, Inc., Greenfield, IN 46140, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; QTest Labs, 6456 Fiesta Drive, Columbus, OH 43235, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Eli Lilly & Company, Indianapolis, IN 46225, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; UCB BioPharma SPRL, Non Clinical Development, Chemin du Foriest, B-1420 Braine-l'Alleud, Belgium. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; XenoMetrics LLC, PO Box 401, Stilwell, KS 66085, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Janssen Pharmaceuticals LLC, 1000 Route 202 South, Raritan, NJ 08869, USA. PY - 2015 SP - 1 EP - 4 VL - 75 KW - Index Medicus KW - Respiratory KW - ICH M3 KW - Core battery KW - Central nervous systems KW - ICH S7B KW - Diplomate in Safety Pharmacology (DSP) KW - Certification KW - Safety pharmacology (SP) KW - Cardiovascular KW - ICH S7A KW - Animals KW - Drug Industry -- standards KW - Societies, Scientific -- organization & administration KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Pharmacology -- standards KW - Professional Competence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717484836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmacological+and+toxicological+methods&rft.atitle=The+Diplomate+in+Safety+Pharmacology+%28DSP%29+certification+scheme.&rft.au=Authier%2C+Simon%3BCurtis%2C+Michael+J%3BSoloviev%2C+Maxim%3BRedfern%2C+Will+S%3BKallman%2C+Mary+Jeanne%3BHamlin%2C+Robert+L%3BLeishman%2C+Derek+J%3BValentin%2C+Jean-Pierre%3BKoerner%2C+John+E%3BVargas%2C+Hugo+M%3BBotchway%2C+Alfred%3BCorrell%2C+Krystle%3BPugsley%2C+Michael+K&rft.aulast=Authier&rft.aufirst=Simon&rft.date=2015-09-01&rft.volume=75&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmacological+and+toxicological+methods&rft.issn=1873-488X&rft_id=info:doi/10.1016%2Fj.vascn.2015.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-06 N1 - Date created - 2015-09-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.vascn.2015.04.008 ER - TY - JOUR T1 - Translational biomarkers of acetaminophen-induced acute liver injury AN - 1712777519; PQ0001989125 AB - Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury. The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury. JF - Archives of Toxicology AU - Beger, Richard D AU - Bhattacharyya, Sudeepa AU - Yang, Xi AU - Gill, Pritmohinder S AU - Schnackenberg, Laura K AU - Sun, Jinchun AU - James, Laura P AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, USA, Richard.Beger@fda.hhs.gov Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 1497 EP - 1522 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 89 IS - 9 SN - 0340-5761, 0340-5761 KW - Toxicology Abstracts KW - Translation KW - Liver diseases KW - Injuries KW - Glutathione KW - Mitochondria KW - biomarkers KW - Oxygen KW - Necrosis KW - Protein adducts KW - Reviews KW - Liver KW - Analgesics KW - proteomics KW - Drugs KW - metabolomics KW - Acetaminophen KW - Nitrogen KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712777519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=Translational+biomarkers+of+acetaminophen-induced+acute+liver+injury&rft.au=Beger%2C+Richard+D%3BBhattacharyya%2C+Sudeepa%3BYang%2C+Xi%3BGill%2C+Pritmohinder+S%3BSchnackenberg%2C+Laura+K%3BSun%2C+Jinchun%3BJames%2C+Laura+P&rft.aulast=Beger&rft.aufirst=Richard&rft.date=2015-09-01&rft.volume=89&rft.issue=9&rft.spage=1497&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-015-1519-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 214 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Translation; Liver diseases; Injuries; Glutathione; Mitochondria; biomarkers; Oxygen; Necrosis; Protein adducts; Reviews; Liver; proteomics; Analgesics; Drugs; Acetaminophen; metabolomics; Nitrogen DO - http://dx.doi.org/10.1007/s00204-015-1519-4 ER - TY - JOUR T1 - Biotransformations of organic compounds mediated by cultures of Aspergillus niger AN - 1712772662; PQ0001939480 AB - Many different organic compounds may be converted by microbial biotransformation to high-value products for the chemical and pharmaceutical industries. This review summarizes the use of strains of Aspergillus niger, a well-known filamentous fungus used in numerous biotechnological processes, for biochemical transformations of organic compounds. The substrates transformed include monocyclic, bicyclic, and polycyclic aromatic hydrocarbons; azaarenes, epoxides, chlorinated hydrocarbons, and other aliphatic and aromatic compounds. The types of reactions performed by A. niger, although not unique to this species, are extremely diverse. They include hydroxylation, oxidation of various functional groups, reduction of double bonds, demethylation, sulfation, epoxide hydrolysis, dechlorination, ring cleavage, and conjugation. Some of the products may be useful as new investigational drugs or chemical intermediates. JF - Applied Microbiology and Biotechnology AU - Parshikov, Igor A AU - Woodling, Kellie A AU - Sutherland, John B AD - Institute of Applied Mechanics, Russian Academy of Sciences, Moscow, 119991, Russia, john.sutherland@fda.hhs.gov Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 6971 EP - 6986 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 99 IS - 17 SN - 0175-7598, 0175-7598 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Transformation KW - Dechlorination KW - Polycyclic aromatic hydrocarbons KW - Epoxides KW - biotransformation KW - Hydrolysis KW - Chlorinated hydrocarbons KW - Hydroxylation KW - Demethylation KW - Aromatic compounds KW - Oxidation KW - Pharmaceuticals KW - Organic compounds KW - Drugs KW - Aspergillus niger KW - J 02310:Genetics & Taxonomy KW - W 30950:Waste Treatment & Pollution Clean-up KW - A 01320:Microbial Degradation KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712772662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Enhancing+STD+Practitioners%27+Understanding+of+Syphilis+Staging%3A+An+Interactive+Case-Conference+Training+Module&rft.au=Thomas%2C+Michael%3BMitchell%2C+Carolyn%3BThornton%2C+Lupita%3BHickenbotham%2C+Algia%3BMcNeese-Ward%2C+Marlene&rft.aulast=Thomas&rft.aufirst=Michael&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 80 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Transformation; Dechlorination; Epoxides; Polycyclic aromatic hydrocarbons; biotransformation; Hydrolysis; Chlorinated hydrocarbons; Hydroxylation; Demethylation; Aromatic compounds; Oxidation; Pharmaceuticals; Organic compounds; Drugs; Aspergillus niger DO - http://dx.doi.org/10.1007/s00253-015-6765-0 ER - TY - JOUR T1 - Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk. AN - 1709707074; 26214118 AB - The role of the chemical environment in disease initiation or progression is becoming more evident. Endocrine disruption via environmental chemicals is now well documented in humans, rodent research models, and wildlife. Breast cancer is an endocrine-based disease whose risk may be modified by environmental exposures. Our purpose is to encourage more investigation into early life environmental exposures as they relate to breast cancer risk factors and disease over a lifetime. The 2009 President's Cancer Panel, 2012 Institute of Medicine, 2013 Interagency Breast Cancer and the Environment Research Coordinating Committee reports, and research publications dated ≥2012 in PubMed were used to inform our perspective. Literature was reviewed and evidence gathered on the effects of the environment on risk of breast cancer or mammary tumor development in animal research models as it pertained to the influence of timing of exposure on later-life outcomes. Evidence has accumulated for several chemicals that environmental factors have a stronger effect on breast cancer risk when exposure occurred early in life. The insecticide, dichlorodiphenyltrichloroethane, is an excellent example and is just one of several chemicals for which there seems to be both animal and human evidence for the developmental basis of adult disease. The developing breast undergoes many changes in early life, leaving it vulnerable to the effects of epigenetic marks, endocrine disruption, and carcinogens. More research is needed in the area of early beginnings of breast cancer, with prevention of the disease as the ultimate goal. JF - The Journal of clinical endocrinology and metabolism AU - Fenton, Suzanne E AU - Birnbaum, Linda S AD - National Toxicology Program (NTP) Laboratory, Division of the NTP (S.E.F.), National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 3245 EP - 3250 VL - 100 IS - 9 KW - Endocrine Disruptors KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Time Factors KW - Endocrine Disruptors -- toxicity KW - Breast Neoplasms -- pathology KW - Environmental Exposure KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709707074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Timing+of+Environmental+Exposures+as+a+Critical+Element+in+Breast+Cancer+Risk.&rft.au=Fenton%2C+Suzanne+E%3BBirnbaum%2C+Linda+S&rft.aulast=Fenton&rft.aufirst=Suzanne&rft.date=2015-09-01&rft.volume=100&rft.issue=9&rft.spage=3245&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=1945-7197&rft_id=info:doi/10.1210%2Fjc.2015-2848 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-24 N1 - Date created - 2015-09-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Epidemiology. 1999 Nov;10(6):722-32 [10535787] Reprod Toxicol. 2015 Jul;54:58-65 [25277313] Reprod Toxicol. 2015 Jul;54:136-40 [25554384] Am J Clin Nutr. 2000 May;71(5 Suppl):1344S-52S [10799412] Am J Epidemiol. 2000 Aug 15;152(4):363-70 [10968381] Environ Health Perspect. 2001 Mar;109 Suppl 1:35-47 [11250804] Int J Cancer. 2001 Feb 15;91(4):568-74 [11251983] Toxicol Sci. 2001 Jul;62(1):46-53 [11399792] Toxicol Sci. 2002 May;67(1):63-74 [11961217] Environ Health Perspect. 2002 Jul;110(7):625-8 [12117637] Environ Health Perspect. 2002 Aug;110(8):771-6 [12153757] Environ Health Perspect. 2003 Apr;111(4):389-94 [12676588] Environ Health Perspect. 2004 Feb;112(2):207-14 [14754575] N Engl J Med. 1984 Nov 29;311(22):1393-8 [6493300] Lancet. 1986 May 10;1(8489):1077-81 [2871345] BMJ. 1995 Jul 15;311(6998):171-4 [7613432] Toxicol Appl Pharmacol. 1997 Jan;142(1):192-200 [9007049] Lancet. 1997 Oct 18;350(9085):1131-5 [9343501] Carcinogenesis. 1998 Sep;19(9):1623-9 [9771934] Cad Saude Publica. 1998;14 Suppl 3:125-32 [9819471] J Biochem Mol Toxicol. 1999;13(6):296-302 [10487416] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1509-14 [16896041] Environ Health Perspect. 2007 Oct;115(10):1406-14 [17938728] Chemosphere. 2008 Oct;73(6):999-1004 [18707752] Pediatrics. 2009 May;123(5):e932-9 [19403485] Endocr Rev. 2009 Jun;30(4):293-342 [19502515] Environ Health Perspect. 2010 May;118(5):596-601 [20435547] Environ Health Perspect. 2011 Aug;119(8):1070-6 [21501981] N Engl J Med. 2011 Oct 6;365(14):1304-14 [21991952] Environ Health Perspect. 2011 Dec;119(12):1700-5 [21810551] Annu Rev Pharmacol Toxicol. 2012;52:455-79 [22017681] Environ Health Perspect. 2012 Aug;120(8):1170-6 [22514210] Occup Environ Med. 2012 Sep;69(9):636-42 [22767868] J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):43-61 [23417729] Birth Defects Res C Embryo Today. 2013 Jun;99(2):134-46 [23897597] Obesity (Silver Spring). 2013 Jun;21(6):1079-80 [23784921] Mol Endocrinol. 2013 Oct;27(10):1666-77 [24002655] J Clin Endocrinol Metab. 2015 Aug;100(8):2865-72 [26079774] Regul Toxicol Pharmacol. 2013 Dec;67(3):421-33 [24021539] Pediatrics. 2013 Dec;132(6):1019-27 [24190685] Breast Cancer Res. 2014;16(2):208 [25032259] J Obstet Gynaecol. 2015 Jan;35(1):60-3 [25020211] Sci Total Environ. 2015 Jul 1;520:106-13 [25804877] Biol Reprod. 2001 Oct;65(4):1215-23 [11566746] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1210/jc.2015-2848 ER - TY - JOUR T1 - Prediagnostic Serum Organochlorine Concentrations and Metastatic Prostate Cancer: A Nested Case-Control Study in the Norwegian Janus Serum Bank Cohort. AN - 1709393655; 25734605 AB - Organochlorine (OC) insecticides and polychlorinated biphenyls (PCBs) have been shown to have estrogenic, antiestrogenic, or antiandrogenic properties; as a result, the impact of exposure to these compounds and risk of hormonal cancers, such as prostate cancer, is a concern. We conducted a nested case-control study, using prospectively collected serum, to estimate associations between OC exposures and metastatic prostate cancer in a population-based cohort from Norway. Sera from 150 cases and 314 controls matched on date of blood draw, age at blood draw, and region was used to determine concentrations of 11 OC pesticide metabolites and 34 PCB congeners. Odds ratios (ORs) and 95% confidence intervals (95% CIs) for quartiles of lipid-corrected metabolite levels were calculated using conditional logistic regression. Metastatic prostate cancer was two times as likely among men with serum concentrations of oxychlordane in the highest quartile compared with those in the lowest quartile (OR = 2.03; 95% CI: 1.03, 4.03; p-trend 0.05). Elevated but nonsignificant ORs were estimated for the highest versus lowest quartile of heptachlor epoxide, HCB, and mirex, although these exposures were correlated with oxychlordane. Findings for specific PCB congeners showed a significant inverse association between natural log-transformed lipid-adjusted PCB 44 and metastatic prostate cancer (OR = 0.74; 95% CI: 0.56, 0.97; p-trend = 0.02). Our study highlights the importance of estimating associations with specific OC chemicals and suggests a possible role of OC insecticides and PCBs in the etiology of metastatic prostate cancer. Koutros S, Langseth H, Grimsrud TK, Barr DB, Vermeulen R, Portengen L, Wacholder S, Beane Freeman LE, Blair A, Hayes RB, Rothman N, Engel LS. 2015. Prediagnostic serum organochlorine concentrations and metastatic prostate cancer: a nested case-control study in the Norwegian Janus Serum Bank cohort. Environ Health Perspect 123:867-872; http://dx.doi.org/10.1289/ehp.1408245. JF - Environmental health perspectives AU - Koutros, Stella AU - Langseth, Hilde AU - Grimsrud, Tom K AU - Barr, Dana Boyd AU - Vermeulen, Roel AU - Portengen, Lützen AU - Wacholder, Sholom AU - Freeman, Laura E Beane AU - Blair, Aaron AU - Hayes, Richard B AU - Rothman, Nathaniel AU - Engel, Lawrence S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 867 EP - 872 VL - 123 IS - 9 KW - Hydrocarbons, Chlorinated KW - 0 KW - Insecticides KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Prospective Studies KW - Logistic Models KW - Humans KW - Polychlorinated Biphenyls -- blood KW - Adult KW - Neoplasm Metastasis KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Norway KW - Male KW - Prostatic Neoplasms -- pathology KW - Hydrocarbons, Chlorinated -- blood KW - Prostatic Neoplasms -- blood KW - Prostatic Neoplasms -- chemically induced KW - Insecticides -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709393655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Surgical+Smoke+and+Healthcare+Worker+Health+and+Safety&rft.au=Steege%2C+Andrea%3BBoiano%2C+Jim%3BHaring+Sweeney%2C+Marie&rft.aulast=Steege&rft.aufirst=Andrea&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-31 N1 - Date created - 2015-09-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2010 Jun;118(6):796-802 [20146964] J Expo Sci Environ Epidemiol. 2010 Jul;20(5):434-45 [19513097] J Clin Oncol. 2010 Jul 20;28(21):3457-62 [20566993] Chemosphere. 2010 Sep;81(4):464-8 [20817259] Am J Epidemiol. 2013 Jan 1;177(1):59-74 [23171882] Lancet Oncol. 2013 Apr;14(4):287-8 [23499544] J Occup Environ Med. 2003 Jul;45(7):692-702 [12855910] Chemosphere. 2004 Mar;54(10):1509-20 [14659953] Environ Health Perspect. 1989 May;81:225-39 [2503374] Environ Health Perspect. 1997 Jan;105(1):13-4 [9074863] Annu Rev Public Health. 1997;18:211-44 [9143718] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] Int Arch Occup Environ Health. 2004 Nov;77(8):559-70 [15688248] Environ Res. 2005 May;98(1):104-13 [15721890] J Occup Environ Med. 2006 Jul;48(7):700-7 [16832227] Environ Health Perspect. 2006 Oct;114(10):1508-14 [17035134] Int J Cancer. 2007 Feb 1;120(3):642-9 [17096337] Cancer Res. 2007 Jun 1;67(11):5545-52 [17545638] Int J Cancer. 2007 Oct 1;121(7):1571-8 [17450530] J Natl Cancer Inst. 2007 Dec 19;99(24):1881-7 [18073376] Endocr Rev. 2009 Jun;30(4):293-342 [19502515] Mol Nutr Food Res. 2009 Nov;53(11):1438-51 [19842105] Environ Health Perspect. 2009 Oct;117(10):1514-9 [20019899] Environ Health Perspect. 2010 Jan;118(1):60-6 [20056587] Acta Oncol. 2010 Apr;49(3):368-77 [20059313] Environ Health Perspect. 2010 May;118(5):659-65 [20435560] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408245 ER - TY - JOUR T1 - Application of Physiologically Based Absorption Modeling for Amphetamine Salts Drug Products in Generic Drug Evaluation AN - 1709191129; PQ0001891325 AB - Amphetamine (AMP) salts-based extended-release (ER) drug products are widely used for the treatment of attention deficit hyperactivity disorder. We developed physiologically based absorption models for mixed AMP salts ER capsules and dextroamphetamine sulfate ER capsules to address specific questions raised during generic drug postmarketing surveillance and bioequivalence (BE) guidance development. The models were verified against several data sets. Virtual BE simulations were conducted to assess BE in various populations other than normal healthy subjects where BE studies are generally conducted for approval. The models were also used to predict pharmacokinetics (PK) for hypothetical formulations having dissolution profiles falling within specification after the development of in vitro-in vivo relation. Finally, we demonstrated how to use the models to test sensitivity of PK metrics to the changes in formulation variables. copyright 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3170-3182, 2015 JF - Journal of Pharmaceutical Sciences AU - Babiskin, Andrew H AU - Zhang, Xinyuan AD - Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, 20993. Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 3170 EP - 3182 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 9 SN - 0022-3549, 0022-3549 KW - Toxicology Abstracts KW - Salts KW - Data processing KW - Attention deficit hyperactivity disorder KW - Dissolution KW - Drug development KW - Amphetamine KW - AMP KW - Drug abuse KW - Pharmacokinetics KW - Models KW - Sulfate KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709191129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Application+of+Physiologically+Based+Absorption+Modeling+for+Amphetamine+Salts+Drug+Products+in+Generic+Drug+Evaluation&rft.au=Babiskin%2C+Andrew+H%3BZhang%2C+Xinyuan&rft.aulast=Babiskin&rft.aufirst=Andrew&rft.date=2015-09-01&rft.volume=104&rft.issue=9&rft.spage=3170&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24474 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Salts; Data processing; Attention deficit hyperactivity disorder; Dissolution; AMP; Amphetamine; Drug development; Drug abuse; Pharmacokinetics; Sulfate; Models DO - http://dx.doi.org/10.1002/jps.24474 ER - TY - JOUR T1 - Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses. AN - 1708158449; 26048654 AB - Triclosan is an antimicrobial chemical incorporated into many personal, medical and household products. Approximately, 75% of the U.S. population has detectable levels of triclosan in their urine, and although it is not typically considered a contact sensitizer, recent studies have begun to link triclosan exposure with augmented allergic disease. We examined the effects of dermal triclosan exposure on the skin and lymph nodes of mice and in a human skin model to identify mechanisms for augmenting allergic responses. Triclosan (0%-3%) was applied topically at 24-h intervals to the ear pinnae of OVA-sensitized BALB/c mice. Skin and draining lymph nodes were evaluated for cellular responses and cytokine expression over time. The effects of triclosan (0%-0.75%) on cytokine expression in a human skin tissue model were also examined. Exposure to triclosan increased the expression of TSLP, IL-1β, and TNF-α in the skin with concomitant decreases in IL-25, IL-33, and IL-1α. Similar changes in TSLP, IL1B, and IL33 expression occurred in human skin. Topical application of triclosan also increased draining lymph node cellularity consisting of activated CD86(+)GL-7(+) B cells, CD80(+)CD86(+) dendritic cells, GATA-3(+)OX-40(+)IL-4(+)IL-13(+) Th2 cells and IL-17 A(+) CD4 T cells. In vivo antibody blockade of TSLP reduced skin irritation, IL-1β expression, lymph node cellularity, and Th2 responses augmented by triclosan. Repeated dermal exposure to triclosan induces TSLP expression in skin tissue as a potential mechanism for augmenting allergic responses. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Marshall, Nikki B AU - Lukomska, Ewa AU - Long, Carrie M AU - Kashon, Michael L AU - Sharpnack, Douglas D AU - Nayak, Ajay P AU - Anderson, Katie L AU - Jean Meade, B AU - Anderson, Stacey E AD - *Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505;Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 andVet Path Services, Inc., Mason 45040, Ohio nmarshall@cdc.gov. ; *Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; ; Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 and. ; Vet Path Services, Inc., Mason 45040, Ohio. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 127 EP - 139 VL - 147 IS - 1 KW - Anti-Infective Agents, Local KW - 0 KW - Cytokines KW - thymic stromal lymphopoietin KW - Triclosan KW - 4NM5039Y5X KW - Index Medicus KW - TSLP KW - triclosan KW - Th2 KW - OVA KW - allergy KW - Animals KW - Humans KW - In Vitro Techniques KW - Adaptive Immunity -- drug effects KW - Mice KW - Mice, Inbred BALB C KW - Lymph Nodes -- drug effects KW - Administration, Topical KW - Dermatitis, Allergic Contact -- immunology KW - Stromal Cells -- drug effects KW - Cytokines -- biosynthesis KW - Th2 Cells -- drug effects KW - Anti-Infective Agents, Local -- toxicity KW - Triclosan -- toxicity KW - Dermatitis, Allergic Contact -- pathology KW - Stromal Cells -- metabolism KW - Th2 Cells -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708158449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Triclosan+Induces+Thymic+Stromal+Lymphopoietin+in+Skin+Promoting+Th2+Allergic+Responses.&rft.au=Marshall%2C+Nikki+B%3BLukomska%2C+Ewa%3BLong%2C+Carrie+M%3BKashon%2C+Michael+L%3BSharpnack%2C+Douglas+D%3BNayak%2C+Ajay+P%3BAnderson%2C+Katie+L%3BJean+Meade%2C+B%3BAnderson%2C+Stacey+E&rft.aulast=Marshall&rft.aufirst=Nikki&rft.date=2015-09-01&rft.volume=147&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-23 N1 - Date created - 2015-08-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Allergy Clin Immunol. 2012 Aug;130(2):453-60.e7 [22704536] Allergy. 2013 Jan;68(1):84-91 [23146048] PLoS One. 2013;8(1):e51268 [23300949] Toxicol Sci. 2013 Mar;132(1):96-106 [23192912] Adv Pharmacol. 2013;66:129-55 [23433457] J Invest Dermatol. 2013 Dec;133(12):2714-21 [23698100] Pediatr Allergy Immunol. 2013 Dec;24(8):762-71 [24299467] Ann Allergy Asthma Immunol. 2014 Feb;112(2):179-181.e2 [24468262] N Engl J Med. 2014 May 29;370(22):2102-10 [24846652] J Immunol. 2015 Feb 1;194(3):1372-80 [25539812] Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1536-41 [19188585] PLoS Biol. 2009 May 19;7(5):e1000067 [19557146] J Invest Dermatol. 2010 Oct;130(10):2505-7 [20555350] J Allergy Clin Immunol. 2010 Nov;126(5):976-84, 984.e1-5 [21050944] Environ Health Perspect. 2011 Mar;119(3):390-6 [21062687] Nature. 2011 Dec 8;480(7376):S2-3 [22158296] Mucosal Immunol. 2012 May;5(3):342-51 [22354320] Genome Res. 2012 May;22(5):850-9 [22310478] Allergy Asthma Proc. 2014 Nov-Dec;35(6):475-81 [25584915] J Occup Environ Med. 2014 Aug;56(8):834-9 [25099409] J Immunotoxicol. 2016;13(2):165-72 [25812624] Environ Toxicol. 2016 May;31(5):609-23 [25410937] J Exp Med. 2001 Feb 5;193(3):387-92 [11157058] Environ Sci Technol. 2002 Mar 15;36(6):1202-11 [11944670] Nat Immunol. 2002 Jul;3(7):673-80 [12055625] J Exp Med. 2003 Jul 21;198(2):315-24 [12860930] Dermatologica. 1979;158(5):379-83 [374145] J Hosp Infect. 1988 Apr;11(3):226-43 [2899107] J Hosp Infect. 1990 Feb;15(2):143-8 [1969436] Nature. 1998 Aug 6;394(6693):531-2 [9707111] J Biol Chem. 1999 Apr 16;274(16):11110-4 [10196195] Nature. 1999 Apr 1;398(6726):383-4 [10201369] J Exp Med. 2005 Aug 15;202(4):541-9 [16103410] J Exp Med. 2005 Sep 19;202(6):829-39 [16172260] Nat Immunol. 2005 Oct;6(10):1047-53 [16142237] J Exp Med. 2005 Nov 7;202(9):1213-23 [16275760] J Immunol. 2007 Mar 15;178(6):3373-7 [17339431] J Clin Invest. 2007 Dec;117(12):3868-78 [18060034] Environ Health Perspect. 2008 Mar;116(3):303-7 [18335095] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv113 ER - TY - JOUR T1 - Acute and recent air pollution exposure and cardiovascular events at labour and delivery. AN - 1707558434; 26105036 AB - To study the relationship between acute air pollution exposure and cardiovascular events during labour/delivery. The Consortium on Safe Labor (2002-2008), an observational US cohort with 223,502 singleton deliveries provided electronic medical records. Air pollution exposure was estimated by modified Community Multiscale Air Quality models. Cardiovascular events (cardiac failure/arrest, stroke, myocardial infarcts and other events) were recorded in the hospital discharge records for 687 pregnancies (0.3%). Logistic regression with generalised estimating equations estimated the relationship between cardiovascular events and daily air pollutant levels for delivery day and the 7 days preceding delivery. Increased odds of cardiovascular events were observed for each IQR increase in exposure to nitric oxides at 5 and 6 days prior to delivery (OR=1.17, 99% CI 1.04 to 1.30 and OR=1.15, 1.03 to 1.28, respectively). High exposure to toxic air pollution species such as ethylbenzene (OR=1.50, 1.08 to 2.09), m-xylene (OR=1.54, 1.11 to 2.13), o-xylene (OR=1.51, 1.09 to 2.09), p-xylene (OR=1.43, 1.03 to 1.99) and toluene (OR=1.42, 1.02 to 1.97) at 5 days prior to delivery were also associated with cardiovascular events. Decreased odds of events were observed with exposure to ozone. Air pollution in the days prior to delivery, especially nitrogen oxides and some toxic air pollution species, was associated with increased risk of cardiovascular events during the labour/delivery admission. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Heart (British Cardiac Society) AU - Männistö, Tuija AU - Mendola, Pauline AU - Laughon Grantz, Katherine AU - Leishear, Kira AU - Sundaram, Rajeshwari AU - Sherman, Seth AU - Ying, Qi AU - Liu, Danping AD - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA Northern Finland Laboratory Centre NordLab, Oulu, Finland Department of Clinical Chemistry, University of Oulu, Oulu, Finland Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland Department of Chronic Disease Prevention, National Institute for Health and Welfare, Oulu, Finland. ; Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA. ; Glotech Inc., Rockville, Maryland, USA US Food and Drug Administration, Silver Spring, Maryland, USA. ; Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA. ; The EMMES Corporation, Rockville, Maryland, USA. ; Zachry Department of Civil Engineering, Texas A&M University, College Station, Texas, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 1491 EP - 1498 VL - 101 IS - 18 KW - Nitrogen Oxides KW - 0 KW - Xylenes KW - Ozone KW - 66H7ZZK23N KW - Abridged Index Medicus KW - Index Medicus KW - Electronic Health Records KW - Delivery, Obstetric -- mortality KW - Risk Factors KW - Humans KW - Adult KW - Outcome Assessment (Health Care) KW - Delivery, Obstetric -- methods KW - United States -- epidemiology KW - Male KW - Female KW - Risk Assessment KW - Pregnancy KW - Ozone -- analysis KW - Air Pollution -- analysis KW - Pregnancy Complications, Cardiovascular -- epidemiology KW - Environmental Exposure -- analysis KW - Nitrogen Oxides -- analysis KW - Xylenes -- toxicity KW - Air Pollution -- adverse effects KW - Pregnancy Complications, Cardiovascular -- prevention & control KW - Pregnancy Complications, Cardiovascular -- chemically induced KW - Environmental Exposure -- adverse effects KW - Nitrogen Oxides -- toxicity KW - Xylenes -- analysis KW - Ozone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707558434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Heart+%28British+Cardiac+Society%29&rft.atitle=Acute+and+recent+air+pollution+exposure+and+cardiovascular+events+at+labour+and+delivery.&rft.au=M%C3%A4nnist%C3%B6%2C+Tuija%3BMendola%2C+Pauline%3BLaughon+Grantz%2C+Katherine%3BLeishear%2C+Kira%3BSundaram%2C+Rajeshwari%3BSherman%2C+Seth%3BYing%2C+Qi%3BLiu%2C+Danping&rft.aulast=M%C3%A4nnist%C3%B6&rft.aufirst=Tuija&rft.date=2015-09-01&rft.volume=101&rft.issue=18&rft.spage=1491&rft.isbn=&rft.btitle=&rft.title=Heart+%28British+Cardiac+Society%29&rft.issn=1468-201X&rft_id=info:doi/10.1136%2Fheartjnl-2014-307366 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-16 N1 - Date created - 2015-08-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/heartjnl-2014-307366 ER - TY - JOUR T1 - Reproductive hormone levels and differential mitochondria-related oxidative gene expression as potential mechanisms for gender differences in cardiosensitivity to Doxorubicin in tumor-bearing spontaneously hypertensive rats. AN - 1705735414; 26108538 AB - Chemotherapy with doxorubicin (Dox) causes dose-limiting cardiotoxicity. We investigated the role that gender has on cardiosensitivity to Dox treatment by evaluating reproductive hormone levels in male, castrated male (c-male), female and ovariectomized female (o-female) adult spontaneously hypertensive rats (SHRs) and expression of mitochondria-related genes in male and female adult SHRs. SST-2 breast tumor-bearing SHRs were treated with saline, Dox, dexrazoxane (Drz) or both Dox and Drz and monitored for 14 days. Tumor size was used to monitor anticancer activity. Heart weight, cardiac lesion score and serum levels of cardiac troponin T (cTnT) were used to determine cardiotoxicity. Serum estradiol (E2) and testosterone were evaluated using electrochemiluminescence immunoassays. Expression of mitochondria-related genes was profiled in heart by MitoChip array analyses. Dox significantly reduced tumor volume (±Drz) and increased heart weight in all genders (13-30% vs. control). Higher heart lesion scores were observed in reproductively normal animals (male 2.9, female 2.2) than in hormone-deficient animals (c-male 1.7, o-female 1.9). Lesion score and cTnT inversely correlated with hormone levels. Reduced levels of both sex hormones were observed after Dox treatment. Gene expression analyses of Dox-treated hearts showed significant differential expression of oxidative stress genes in male hearts and apoptotic genes in both male and female hearts. Our results demonstrate that adult tumor-bearing male SHRs are more cardiosensitive to Dox than female or hormone-deficient animals. We provide evidence to suggest that reproductive hormones negatively regulate or are inhibited by Dox-induced cardiotoxicity and the selective cytotoxic mechanism likely functions through the greater activation of oxidative stress and apoptosis in male SHRs. JF - Cancer chemotherapy and pharmacology AU - Gonzalez, Yanira AU - Pokrzywinski, Kaytee L AU - Rosen, Elliot T AU - Mog, Steven AU - Aryal, Baikuntha AU - Chehab, Leena M AU - Vijay, Vikrant AU - Moland, Carrie L AU - Desai, Varsha G AU - Dickey, Jennifer S AU - Rao, V Ashutosh AD - Laboratory of Chemistry, Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave/Bldg 52/72 Rm 2212, Silver Spring, MD, 20993, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 447 EP - 459 VL - 76 IS - 3 KW - Gonadal Steroid Hormones KW - 0 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Rats KW - Models, Animal KW - Gene Expression -- drug effects KW - Animals KW - Rats, Inbred SHR KW - Sex Factors KW - Apoptosis -- physiology KW - Mammary Neoplasms, Experimental -- drug therapy KW - Oxidative Stress -- genetics KW - Mammary Neoplasms, Experimental -- metabolism KW - Male KW - Female KW - Hypertension -- chemically induced KW - Doxorubicin -- pharmacology KW - Heart Diseases -- chemically induced KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism KW - Heart Diseases -- metabolism KW - Gonadal Steroid Hormones -- metabolism KW - Doxorubicin -- toxicity KW - Mitochondria -- genetics KW - Hypertension -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705735414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Reproductive+hormone+levels+and+differential+mitochondria-related+oxidative+gene+expression+as+potential+mechanisms+for+gender+differences+in+cardiosensitivity+to+Doxorubicin+in+tumor-bearing+spontaneously+hypertensive+rats.&rft.au=Gonzalez%2C+Yanira%3BPokrzywinski%2C+Kaytee+L%3BRosen%2C+Elliot+T%3BMog%2C+Steven%3BAryal%2C+Baikuntha%3BChehab%2C+Leena+M%3BVijay%2C+Vikrant%3BMoland%2C+Carrie+L%3BDesai%2C+Varsha+G%3BDickey%2C+Jennifer+S%3BRao%2C+V+Ashutosh&rft.aulast=Gonzalez&rft.aufirst=Yanira&rft.date=2015-09-01&rft.volume=76&rft.issue=3&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-015-2786-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-17 N1 - Date created - 2015-08-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00280-015-2786-8 ER - TY - JOUR T1 - A Survey of Neonatal Pharmacokinetic and Pharmacodynamic Studies in Pediatric Drug Development. AN - 1705476582; 25975723 AB - Conducting clinical trials in neonates is challenging, and knowledge gaps in neonatal clinical pharmacology exist. We surveyed the US Food and Drug Administration databases and identified 43 drugs studied in neonates or referring to neonates between 1998 and 2014. Twenty drugs were approved in neonates. For 10 drugs, approval was based on efficacy data in neonates, supplemented by pharmacokinetic data for four drugs. Approval for neonates was based on full extrapolation from older patients for six drugs, and partial extrapolation was the basis of approval for four drugs. Dosing recommendations differed from older patients for most drugs, and used body-size based adjustment in neonates. Trial failures were associated with various factors including inappropriate dose selection. Successful drug development in neonates could be facilitated by an improved understanding of the natural history and pathophysiology of neonatal diseases and identification and validation of clinically relevant biomarkers. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Clinical pharmacology and therapeutics AU - Wang, J AU - Avant, D AU - Green, D AU - Seo, S AU - Fisher, J AU - Mulberg, A E AU - McCune, S K AU - Burckart, G J AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ; Office of Pediatric Therapeutics, Commissioner's Office, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ; Division of Biochemical Toxicology, National Center for Toxicology Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. ; Division of Gastroenterology and Inborn Errors Products, Office of Drug Evaluation III, Center for Drug Evaluation and Research, Silver Spring, Maryland, USA, U.S. Food and Drug Administration. ; Office of Translational Sciences, Center for Drug Evaluation and Research U.S. Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 328 EP - 335 VL - 98 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Computer Simulation KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Humans KW - Infant, Newborn KW - Drug-Related Side Effects and Adverse Reactions -- etiology KW - Algorithms KW - Drug-Related Side Effects and Adverse Reactions -- prevention & control KW - Drug Dosage Calculations KW - Models, Biological KW - Risk Assessment KW - Pharmaceutical Preparations -- administration & dosage KW - Infant, Newborn, Diseases -- diagnosis KW - Drug Discovery KW - Pharmaceutical Preparations -- metabolism KW - Infant, Newborn, Diseases -- metabolism KW - Clinical Trials as Topic KW - Pharmacokinetics KW - Infant, Newborn, Diseases -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705476582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=A+Survey+of+Neonatal+Pharmacokinetic+and+Pharmacodynamic+Studies+in+Pediatric+Drug+Development.&rft.au=Wang%2C+J%3BAvant%2C+D%3BGreen%2C+D%3BSeo%2C+S%3BFisher%2C+J%3BMulberg%2C+A+E%3BMcCune%2C+S+K%3BBurckart%2C+G+J&rft.aulast=Wang&rft.aufirst=J&rft.date=2015-09-01&rft.volume=98&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1002%2Fcpt.149 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-03 N1 - Date created - 2015-08-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cpt.149 ER - TY - JOUR T1 - Product quality for nanomaterials: current U.S. experience and perspective AN - 1705076003; PQ0001829260 AB - In recent years, there has been an increased focus on developing novel drug delivery systems and targeted therapies through the use of nanotechnology and nanomaterials. Such focus is translating to an increasing number of investigational new drug (IND) applications, new drug applications (NDAs), and abbreviated new drug applications (ANDAs) for drug products containing nanomaterials to the United States Food and Drug Administration (FDA). Although subject to the same rigorous regulatory standards and regulatory pathways as any drug product, unique properties that arise from the small size, large surface area, and polydispersity of nanomaterials may lead to additional scientific considerations when following current FDA guidelines and practices for drug evaluation. This review article will discuss these scientific considerations based on the experience with FDA-approved drug products containing nanomaterials. WIREs Nanomed Nanobiotechnol 2015, 7:640-654. doi: 10.1002/wnan.1338 For further resources related to this article, please visit the WIREs website . JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Tyner, Katherine M AU - Zou, Peng AU - Yang, Xiaochuan AU - Zhang, Hailing AU - Cruz, Celia N AU - Lee, Sau L AD - CDER/OPQ/SRS, FDA, Silver Springs, MD, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 640 EP - 654 PB - Wiley-Blackwell, Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 7 IS - 5 SN - 1939-5116, 1939-5116 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Surface area KW - Drug development KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705076003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Product+quality+for+nanomaterials%3A+current+U.S.+experience+and+perspective&rft.au=Tyner%2C+Katherine+M%3BZou%2C+Peng%3BYang%2C+Xiaochuan%3BZhang%2C+Hailing%3BCruz%2C+Celia+N%3BLee%2C+Sau+L&rft.aulast=Tyner&rft.aufirst=Katherine&rft.date=2015-09-01&rft.volume=7&rft.issue=5&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19395116&rft_id=info:doi/10.1002%2Fwnan.1338 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Drug delivery; Surface area; Drug development; nanotechnology DO - http://dx.doi.org/10.1002/wnan.1338 ER - TY - JOUR T1 - Prescription Opioids. IV: Disposition of Hydrocodone in Oral Fluid and Blood Following Single-Dose Administration. AN - 1704347614; 25962610 AB - The Substance Abuse and Mental Health Services Administration (SAMHSA) is currently evaluating hydrocodone (HC) for inclusion in the Mandatory Guidelines for Federal Workplace Drug Testing Programs. This study evaluated the time course of HC, norhydrocodone (NHC), dihydrocodeine (DHC) and hydromorphone (HM) in paired oral fluid and whole blood specimens by liquid chromatography-tandem mass spectrometry (limit of quantitation = 1 ng/mL of oral fluid, 5 ng/mL of blood) over a 52-h period. A single dose of HC bitartrate, 20 mg, was administered to 12 subjects. Analyte prevalence was as follows: oral fluid, HC > NHC > DHC; and blood, HC > NHC. HM was not detected in any specimen. HC was frequently detected within 15 min in oral fluid and 30 min in blood. Mean oral fluid to blood (OF : BL) ratios and correlations were 3.2 for HC (r = 0.73) and 0.7 for NHC (r = 0.42). The period of detection for oral fluid exceeded blood at all evaluated thresholds. At a 1-ng/mL threshold for oral fluid, mean detection time was 30 h for HC and 18 h for NHC and DHC. This description of HC and metabolite disposition in oral fluid following single-dose administration provides valuable interpretive guidance of HC test results. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Journal of analytical toxicology AU - Cone, Edward J AU - DePriest, Anne Z AU - Heltsley, Rebecca AU - Black, David L AU - Mitchell, John M AU - LoDico, Charles AU - Flegel, Ron AD - Johns Hopkins School of Medicine, Baltimore, MD, USA. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA University of Tennessee Health Science Center, College of Pharmacy, Memphis, TN, USA anne.depriest@aegislabs.com. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA. ; RTI International, Research Triangle Park, NC, USA. ; Division of Workplace Programs, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 510 EP - 518 VL - 39 IS - 7 KW - Analgesics, Opioid KW - 0 KW - Prescription Drugs KW - norhydrocodone KW - Hydrocodone KW - 6YKS4Y3WQ7 KW - dihydrocodeine KW - N9I9HDB855 KW - Hydromorphone KW - Q812464R06 KW - Codeine KW - Q830PW7520 KW - Index Medicus KW - Hydromorphone -- pharmacokinetics KW - Reproducibility of Results KW - Codeine -- analogs & derivatives KW - Biotransformation KW - Humans KW - Codeine -- pharmacokinetics KW - Chromatography, Liquid KW - Predictive Value of Tests KW - Healthy Volunteers KW - Tissue Distribution KW - Tandem Mass Spectrometry KW - Limit of Detection KW - Hydrocodone -- blood KW - Analgesics, Opioid -- blood KW - Prescription Drugs -- administration & dosage KW - Hydrocodone -- analogs & derivatives KW - Analgesics, Opioid -- pharmacokinetics KW - Saliva -- metabolism KW - Analgesics, Opioid -- administration & dosage KW - Hydrocodone -- pharmacokinetics KW - Hydrocodone -- administration & dosage KW - Prescription Drugs -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704347614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Prescription+Opioids.+IV%3A+Disposition+of+Hydrocodone+in+Oral+Fluid+and+Blood+Following+Single-Dose+Administration.&rft.au=Cone%2C+Edward+J%3BDePriest%2C+Anne+Z%3BHeltsley%2C+Rebecca%3BBlack%2C+David+L%3BMitchell%2C+John+M%3BLoDico%2C+Charles%3BFlegel%2C+Ron&rft.aulast=Cone&rft.aufirst=Edward&rft.date=2015-09-01&rft.volume=39&rft.issue=7&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbkv050 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-18 N1 - Date created - 2015-08-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bkv050 ER - TY - JOUR T1 - Psychosocial work characteristics of personal care and service occupations: a process for developing meaningful measures for a multiethnic workforce AN - 1704346073; 4694590 AB - Background and objectives. Despite their rapid increase in number, workers in personal care and service occupations are underrepresented in research on psychosocial work characteristics and occupational health. Some of the research challenges stem from the high proportion of immigrants in these occupations. Language barriers, low literacy, and cultural differences as well as their nontraditional work setting (i.e., providing service for one person in his/her home) make generic questionnaire measures inadequate for capturing salient aspects of personal care and service work. This study presents strategies for (1) identifying psychosocial work characteristics of home care workers that may affect their occupational safety and health and (2) creating survey measures that overcome barriers posed by language, low literacy, and cultural differences. Reprinted by permission of Taylor & Francis Ltd. JF - Ethnicity and health AU - Hoppe, Annekatrin AU - Heaney, Catherine A AU - Fujishiro, Kaori AU - Gong, Fang AU - Baron, Sherry AD - Stanford University ; National Institute for Occupational Safety and Health ; Ball State University Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 474 EP - 492 VL - 20 IS - 5 SN - 1355-7858, 1355-7858 KW - Sociology KW - Qualitative analysis KW - Workers KW - Language barrier KW - Health care KW - Caring KW - Cultural differences KW - Occupations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704346073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+and+health&rft.atitle=Psychosocial+work+characteristics+of+personal+care+and+service+occupations%3A+a+process+for+developing+meaningful+measures+for+a+multiethnic+workforce&rft.au=Hoppe%2C+Annekatrin%3BHeaney%2C+Catherine+A%3BFujishiro%2C+Kaori%3BGong%2C+Fang%3BBaron%2C+Sherry&rft.aulast=Hoppe&rft.aufirst=Annekatrin&rft.date=2015-09-01&rft.volume=20&rft.issue=5&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Ethnicity+and+health&rft.issn=13557858&rft_id=info:doi/10.1080%2F13557858.2014.925095 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - 2039 13521; 10519 3279 971 3286; 3121 3198 3549 2688 2449 10404; 8864; 5775 13521; 7228 7239 7226; 13682 DO - http://dx.doi.org/10.1080/13557858.2014.925095 ER - TY - JOUR T1 - An in vitro combined antibiotic-antibody treatment eliminates toxicity from Shiga toxin-producing Escherichia coli. AN - 1704345237; 26100707 AB - Treating Shiga toxin-producing Escherichia coli (STEC) gastrointestinal infections is difficult. The utility of antibiotics for STEC treatment is controversial, since antibiotic resistance among STEC isolates is widespread and certain antibiotics dramatically increase the expression of Shiga toxins (Stxs), which are some of the most important virulence factors in STEC. Stxs contribute to life-threatening hemolytic uremic syndrome (HUS), which develops in considerable proportions of patients with STEC infections. Understanding the antibiotic resistance profiles of STEC isolates and the Stx induction potential of promising antibiotics is essential for evaluating any antibiotic treatment of STEC. In this study, 42 O157:H7 or non-O157 STEC isolates (including the "big six" serotypes) were evaluated for their resistance against 22 antibiotics by using an antibiotic array. Tigecycline inhibited the growth of all of the tested STEC isolates and also inhibited the production of Stxs (Stx2 in particular). In combination with neutralizing antibodies to Stx1 and Stx2, the tigecycline-antibody treatment fully protected Vero cells from Stx toxicity, even when the STEC bacteria and the Vero cells were cultured together. The combination of an antibiotic such as tigecycline with neutralizing antibodies presents a promising strategy for future STEC treatments. Copyright © 2015, American Society for Microbiology. All Rights Reserved. JF - Antimicrobial agents and chemotherapy AU - Skinner, Craig AU - Zhang, Guodong AU - Patfield, Stephanie AU - He, Xiaohua AD - Western Regional Research Center, U.S. Department of Agriculture, Agricultural Research Service, Albany, California, USA. ; Center for Food Safety and Applied Nutrition, Food and Drug Administration, Division of Microbiology, College Park, Maryland, USA. ; Western Regional Research Center, U.S. Department of Agriculture, Agricultural Research Service, Albany, California, USA xiaohua.he@ars.usda.gov. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 5435 EP - 5444 VL - 59 IS - 9 KW - Anti-Bacterial Agents KW - 0 KW - Antibodies KW - Antibodies, Neutralizing KW - tigecycline KW - 70JE2N95KR KW - Minocycline KW - FYY3R43WGO KW - Index Medicus KW - Animals KW - Minocycline -- pharmacology KW - Lactobacillus acidophilus -- physiology KW - Cell Survival -- drug effects KW - Cercopithecus aethiops KW - Enzyme-Linked Immunosorbent Assay KW - Vero Cells KW - Antibodies, Neutralizing -- pharmacology KW - Minocycline -- analogs & derivatives KW - Shiga-Toxigenic Escherichia coli -- drug effects KW - Antibodies -- pharmacology KW - Anti-Bacterial Agents -- adverse effects KW - Anti-Bacterial Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704345237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=An+in+vitro+combined+antibiotic-antibody+treatment+eliminates+toxicity+from+Shiga+toxin-producing+Escherichia+coli.&rft.au=Skinner%2C+Craig%3BZhang%2C+Guodong%3BPatfield%2C+Stephanie%3BHe%2C+Xiaohua&rft.aulast=Skinner&rft.aufirst=Craig&rft.date=2015-09-01&rft.volume=59&rft.issue=9&rft.spage=5435&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=1098-6596&rft_id=info:doi/10.1128%2FAAC.00763-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-18 N1 - Date created - 2015-08-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: PLoS One. 2012;7(3):e33637 [22432037] MMWR Recomm Rep. 2009 Oct 16;58(RR-12):1-14 [19834454] Toxins (Basel). 2012 Jul;4(7):487-504 [22852065] J Clin Microbiol. 2012 Sep;50(9):2951-63 [22760050] PLoS One. 2013;8(10):e76368 [24146860] Toxins (Basel). 2013 Oct;5(10):1845-58 [24152988] Ann Clin Microbiol Antimicrob. 2013;12:19 [23941473] PLoS One. 2014;9(5):e95281 [24871339] PLoS One. 2014;9(6):e99854 [24914553] J Clin Microbiol. 2014 Jul;52(7):2346-51 [24759708] Antimicrob Agents Chemother. 2014 Dec;58(12):7560-4 [25267665] J Bacteriol. 1999 Mar;181(6):1767-78 [10074068] J Clin Microbiol. 2012 Nov;50(11):3485-92 [22895033] J Immunol Methods. 2013 Mar 29;389(1-2):18-28 [23279946] Drugs. 2013 Feb;73(2):159-77 [23371303] PLoS One. 2013;8(3):e59760 [23555772] Int J Food Microbiol. 2013 Jun 3;164(1):36-45 [23587712] Emerg Infect Dis. 2013 Jun;19(6):870-8 [23731823] Infection. 2013 Jun;41(3):669-73 [23292662] J Infect Dis. 2002 Jan 1;185(1):74-84 [11756984] N Engl J Med. 2000 Jun 29;342(26):1930-6 [10874060] PLoS One. 2013;8(9):e76563 [24069462] Mol Microbiol. 2002 May;44(4):957-70 [12010491] J Biol Chem. 2004 Jun 25;279(26):27511-7 [15075327] Epidemiol Infect. 1987 Dec;99(3):613-24 [3322851] Mol Microbiol. 1991 Aug;5(8):1817-22 [1766367] Diagn Microbiol Infect Dis. 1993 Mar-Apr;16(3):185-9 [8477572] Int J Food Microbiol. 2010 Jan 1;136(3):290-4 [19875188] Diagn Microbiol Infect Dis. 2011 Jun;70(2):270-3 [21596226] Ann Pharmacother. 2011 Jul;45(7-8):1005-10 [21730279] N Engl J Med. 2011 Nov 10;365(19):1771-80 [21696328] Arch Microbiol. 2011 Dec;193(12):883-91 [21713444] J Food Prot. 2012 Jan;75(1):123-31 [22221364] Clin Ther. 2012 Feb;34(2):496-507.e1 [22249106] Emerg Infect Dis. 2012 Mar;18(3):488-92 [22377117] Infect Immun. 1993 Aug;61(8):3392-402 [8335369] Infection. 1993 May-Jun;21(3):140-5 [8365810] J Clin Microbiol. 1996 Feb;34(2):463-5 [8789041] J Infect Dis. 1998 Apr;177(4):962-6 [9534969] Clin Infect Dis. 1999 Nov;29(5):1303-6 [10524979] J Antimicrob Chemother. 2005 Jul;56(1):216-9 [15911552] Infect Immun. 2009 Jul;77(7):2813-23 [19380474] Appl Environ Microbiol. 2012 Jun;78(12):4065-73 [22504816] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/AAC.00763-15 ER - TY - JOUR T1 - Nonsmoker Exposure to Secondhand Cannabis Smoke. III. Oral Fluid and Blood Drug Concentrations and Corresponding Subjective Effects. AN - 1704344178; 26139312 AB - The increasing use of highly potent strains of cannabis prompted this new evaluation of human toxicology and subjective effects following passive exposure to cannabis smoke. The study was designed to produce extreme cannabis smoke exposure conditions tolerable to drug-free nonsmokers. Six experienced cannabis users smoked cannabis cigarettes [5.3% Δ(9)-tetrahydrocannabinol (THC) in Session 1 and 11.3% THC in Sessions 2 and 3] in a closed chamber. Six nonsmokers were seated alternately with smokers during exposure sessions of 1 h duration. Sessions 1 and 2 were conducted with no ventilation and ventilation was employed in Session 3. Oral fluid, whole blood and subjective effect measures were obtained before and at multiple time points after each session. Oral fluid was analyzed by ELISA (4 ng/mL cutoff concentration) and by LC-MS-MS (limit of quantitation) for THC (1 ng/mL) and total THCCOOH (0.02 ng/mL). Blood was analyzed by LC-MS-MS (0.5 ng/mL) for THC, 11-OH-THC and free THCCOOH. Positive tests for THC in oral fluid and blood were obtained for nonsmokers up to 3 h following exposure. Ratings of subjective effects correlated with the degree of exposure. Subjective effect measures and amounts of THC absorbed by nonsmokers (relative to smokers) indicated that extreme secondhand cannabis smoke exposure mimicked, though to a lesser extent, active cannabis smoking. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Journal of analytical toxicology AU - Cone, Edward J AU - Bigelow, George E AU - Herrmann, Evan S AU - Mitchell, John M AU - LoDico, Charles AU - Flegel, Ronald AU - Vandrey, Ryan AD - Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA edwardjcone@gmail.com. ; Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; RTI International, Research Triangle Park, NC, USA. ; Division of Workplace Programs (DWP), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 497 EP - 509 VL - 39 IS - 7 KW - Smoke KW - 0 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Humans KW - Chromatography, Liquid KW - Enzyme-Linked Immunosorbent Assay KW - Tandem Mass Spectrometry KW - Time Factors KW - Risk Assessment KW - Smoke -- adverse effects KW - Air Pollution, Indoor -- adverse effects KW - Dronabinol -- metabolism KW - Affect -- drug effects KW - Marijuana Smoking -- adverse effects KW - Dronabinol -- blood KW - Saliva -- metabolism KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704344178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Nonsmoker+Exposure+to+Secondhand+Cannabis+Smoke.+III.+Oral+Fluid+and+Blood+Drug+Concentrations+and+Corresponding+Subjective+Effects.&rft.au=Cone%2C+Edward+J%3BBigelow%2C+George+E%3BHerrmann%2C+Evan+S%3BMitchell%2C+John+M%3BLoDico%2C+Charles%3BFlegel%2C+Ronald%3BVandrey%2C+Ryan&rft.aulast=Cone&rft.aufirst=Edward&rft.date=2015-09-01&rft.volume=39&rft.issue=7&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbkv070 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-18 N1 - Date created - 2015-08-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Pharmacol Biochem Behav. 1994 Sep;49(1):187-95 [7816872] NIDA Res Monogr. 1990;99:42-62 [2176276] NIDA Res Monogr. 1990;99:121-40 [2176275] J Anal Toxicol. 1996 Oct;20(6):441-52 [8889681] Drugs R D. 2003;4(5):306-9 [12952500] Clin Pharmacokinet. 2003;42(4):327-60 [12648025] J Anal Toxicol. 2001 Jul-Aug;25(5):289-303 [11499881] J Anal Toxicol. 2004 Oct;28(7):546-52 [15516313] J Anal Toxicol. 2005 Oct;29(7):607-15 [16419389] J Anal Toxicol. 2006 Sep;30(7):413-8 [16959132] J Anal Toxicol. 2006 Nov-Dec;30(9):645-50 [17137523] J Anal Toxicol. 2007 May;31(4):187-94 [17555641] J Anal Toxicol. 2007 Jun;31(5):288-93 [17579974] Chem Res Toxicol. 2008 Feb;21(2):494-502 [18062674] J Anal Toxicol. 2008 Oct;32(8):653-8 [19007517] Clin Chem. 2011 Aug;57(8):1127-36 [21677094] Forensic Sci Int. 2011 Oct 10;212(1-3):227-30 [21763088] Clin Chim Acta. 2012 Apr 11;413(7-8):765-70 [22285315] Clin Chem. 2012 Apr;58(4):748-56 [22273566] Drug Alcohol Depend. 2015 Jun 1;151:194-202 [25957157] J Anal Toxicol. 2015 Jan-Feb;39(1):1-12 [25326203] Anal Bioanal Chem. 2013 Oct;405(26):8451-61 [23954944] Clin Pharmacol Ther. 1980 Sep;28(3):409-16 [6250760] J Chromatogr A. 2013 Jul 5;1297:123-30 [23726246] Br J Clin Pharmacol. 2012 Jul;74(1):42-53 [22680341] J Anal Toxicol. 2012 Jul;36(6):413-7 [22532488] Anal Bioanal Chem. 2013 Jul;405(18):6019-27 [23681203] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bkv070 ER - TY - JOUR T1 - Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam. AN - 1704344067; 25663270 AB - Literature and experimental data relevant for the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levetiracetam are reviewed. Data on solubility and permeability suggest that levetiracetam belongs to class I of the biopharmaceutical classification system (BCS). Levetiracetam's therapeutic use, its wide therapeutic index, and its favorable pharmacokinetic properties make levetiracetam a valid candidate for the BCS-based biowaiver approach. Further, no BE studies with levetiracetam IR formulations in which the test formulation failed to show BE with the comparator have been reported in the open literature. On the basis of the overall evidence, it appears unlikely that a BCS-based biowaiver approach for levetiracetam IR solid oral dosage forms formulated with established excipients would expose patients to undue risks. Thus, the BCS-based biowaiver approach procedure is recommended for IR solid oral dosage form containing levetiracetam, provided the excipients in the formulation are also present in products that have been approved in countries belonging to or associated with the International Committee on Harmonization and are used in their usual quantities, and provided the dissolution profiles of the test and reference product comply with the current requirements for BCS-based biowaivers. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association. JF - Journal of pharmaceutical sciences AU - Petruševska, Marija AU - Berglez, Sandra AU - Krisch, Igor AU - Legen, Igor AU - Megušar, Klara AU - Peternel, Luka AU - Abrahamsson, Bertil AU - Cristofoletti, Rodrigo AU - Groot, D W AU - Kopp, Sabine AU - Langguth, Peter AU - Mehta, Mehul AU - Polli, James E AU - Shah, Vinod P AU - Dressman, Jennifer AD - Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology & Toxicology, Skopje, Republic of Macedonia. ; SDC Slovenia, Lek Pharmaceuticals d.d., Ljubljana, 1529, Slovenia. ; AstraZeneca Pharmaceutics, R&D, Mölndal, Sweden. ; Brazilian Health Surveillance Agency (Anvisa), Division of Bioequivalence, Brasilia, Brazil. ; RIVM (National Institute for Public Health and the Environment), Bilthoven, The Netherlands. ; World Health Organization, Geneva, Switzerland. ; Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Johannes Gutenberg - University, Mainz, Germany. ; Center for Drug Evaluation and Research, Office of Clinical Pharmacology, US Food and Drug Administration, Maryland. ; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland. ; International Pharmaceutical Federation (FIP), The Hague, The Netherlands. ; Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 2676 EP - 2687 VL - 104 IS - 9 KW - Anticonvulsants KW - 0 KW - Dosage Forms KW - etiracetam KW - 230447L0GL KW - Piracetam KW - ZH516LNZ10 KW - Index Medicus KW - levetiracetam KW - absorption KW - bioequivalence KW - biowaiver KW - biopharmaceutical classification system (BCS) KW - bioavailability KW - solubility KW - pharmacokinetics KW - permeability KW - Therapeutic Equivalency KW - Permeability KW - Animals KW - Chemistry, Pharmaceutical KW - Biopharmaceutics -- classification KW - Humans KW - Biological Availability KW - Piracetam -- pharmacokinetics KW - Piracetam -- analogs & derivatives KW - Anticonvulsants -- pharmacokinetics KW - Piracetam -- administration & dosage KW - Anticonvulsants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704344067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Biowaiver+Monographs+for+Immediate+Release+Solid+Oral+Dosage+Forms%3A+Levetiracetam.&rft.au=Petru%C5%A1evska%2C+Marija%3BBerglez%2C+Sandra%3BKrisch%2C+Igor%3BLegen%2C+Igor%3BMegu%C5%A1ar%2C+Klara%3BPeternel%2C+Luka%3BAbrahamsson%2C+Bertil%3BCristofoletti%2C+Rodrigo%3BGroot%2C+D+W%3BKopp%2C+Sabine%3BLangguth%2C+Peter%3BMehta%2C+Mehul%3BPolli%2C+James+E%3BShah%2C+Vinod+P%3BDressman%2C+Jennifer&rft.aulast=Petru%C5%A1evska&rft.aufirst=Marija&rft.date=2015-09-01&rft.volume=104&rft.issue=9&rft.spage=2676&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=1520-6017&rft_id=info:doi/10.1002%2Fjps.24350 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-10 N1 - Date created - 2015-08-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jps.24350 ER - TY - JOUR T1 - Feasibility Study of a Novel Experimental Induction Protocol Combining B43-PAP (Anti-CD19) Immunotoxin With Standard Induction Chemotherapy in Children and Adolescents With Relapsed B-Lineage ALL: A Report From the Children's Oncology Group. AN - 1703718275; 26261894 AB - B43-pokeweed antiviral protein (B43-PAP) is a high-affinity anti-CD19 immunotoxin that is capable of causing apoptotic death in B-lineage leukemic cells with a drug-resistant phenotype. B43-PAP exhibited in vivo antileukemic activity in preclinical studies as well as on a single-agent phase I clinical trial. This pediatric phase I/II study evaluated the toxicity profile and efficacy of B43-PAP immunotoxin in combination with standard induction chemotherapy in children and adolescents with relapsed CD19-positive B-lineage acute lymphoblastic leukemia (B-ALL). Pharmacokinetic profile and immunogenicity of B43-PAP were assessed. B43-PAP in combination with standard 3 and 4-drug induction chemotherapy was administered on days 9-13 and 21-25 of a 28-day treatment course with vincristine, prednisone, L-asparaginase, daunomycin, and intrathecal methotrexate. Thirty patients with relapsed B-ALL were enrolled on study CCG-0957. Grade III/IV nonhematologic dose-limiting toxicities were encountered in 4 patients evaluable for toxicity and included myalgias, motor dysfunction, pulmonary toxicity, and elevated liver transaminase. Dose-limiting toxicities occurred only with the 4-drug regimen. Fourteen patients achieved a complete remission at the end of induction among the 20 patients evaluable for response. B43-PAP in combination with standard induction chemotherapy can be safely administered and exhibits clinical antileukemic activity against relapsed B-ALL. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Meany, Holly J AU - Seibel, Nita L AU - Krailo, Mark AU - Villaluna, Doojduen AU - Chen, Zhengjia AU - Gaynon, Paul AU - Neglia, Joseph P AU - Park, Julie R AU - Hutchinson, Raymond AU - Sato, Judith K AU - Wells, Robert J AU - Woods, William G AU - Reaman, Gregory AD - *Department of Pediatric Hematology-Oncology, Children's National Medical Center, George Washington University School of Medicine and Public Health, Washington, DC †Clinical Investigations Branch, Cancer Therapy Evaluation Program, NCI, Bethesda ¶¶Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD ‡Keck School of Medicine, University of Southern California ¶Division of Hematology-Oncology, Children's Hospital Los Angeles, Los Angeles §Children's Oncology Group, Arcadia ‡‡Department of Pediatrics, City of Hope National Medical Center, Duarte, CA ∥Department of Biostatistics and Bioinformatics, Emory University ∥∥Aflac Cancer and Blood Disorder Center, Children's Healthcare of Atlanta/Emory University, Atlanta, GA #Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN **Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA ††Pediatric Hematology-Oncology, C.S. Mott Children's Hospital, Ann Arbor, MI §§Division of Pediatrics, Children's Cancer Hospital at the University of Texas M.D. Anderson Cancer Center, Houston, TX. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 299 EP - 305 VL - 38 IS - 7 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD19 KW - Antineoplastic Agents KW - Immunotoxins KW - Ribosome Inactivating Proteins, Type 1 KW - pokeweed antiviral protein KW - EC 3.2.2.22 KW - Index Medicus KW - Feasibility Studies KW - Induction Chemotherapy -- methods KW - Humans KW - Drug Therapy, Combination -- methods KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Antibodies, Monoclonal -- immunology KW - Antigens, CD19 -- immunology KW - Immunotoxins -- immunology KW - Ribosome Inactivating Proteins, Type 1 -- immunology KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- immunology KW - B-Lymphocytes -- immunology KW - Antineoplastic Agents -- therapeutic use KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703718275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Feasibility+Study+of+a+Novel+Experimental+Induction+Protocol+Combining+B43-PAP+%28Anti-CD19%29+Immunotoxin+With+Standard+Induction+Chemotherapy+in+Children+and+Adolescents+With+Relapsed+B-Lineage+ALL%3A+A+Report+From+the+Children%27s+Oncology+Group.&rft.au=Meany%2C+Holly+J%3BSeibel%2C+Nita+L%3BKrailo%2C+Mark%3BVillaluna%2C+Doojduen%3BChen%2C+Zhengjia%3BGaynon%2C+Paul%3BNeglia%2C+Joseph+P%3BPark%2C+Julie+R%3BHutchinson%2C+Raymond%3BSato%2C+Judith+K%3BWells%2C+Robert+J%3BWoods%2C+William+G%3BReaman%2C+Gregory&rft.aulast=Meany&rft.aufirst=Holly&rft.date=2015-09-01&rft.volume=38&rft.issue=7&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=1537-4513&rft_id=info:doi/10.1097%2FCJI.0000000000000088 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-04 N1 - Date created - 2015-08-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Oncol. 2005 Nov 1;23(31):7942-50 [16258094] Br J Haematol. 2005 Jul;130(1):67-75 [15982346] Br J Haematol. 2006 Nov;135(4):500-8 [17061978] Blood. 2007 Feb 1;109(3):926-35 [17003380] J Clin Oncol. 2007 Dec 20;25(36):5800-7 [18089878] Br J Haematol. 2000 Mar;108(3):531-43 [10759711] Eur J Haematol. 2015 Feb;94(2):99-108 [24981395] Curr Opin Pediatr. 2008 Feb;20(1):17-22 [18197034] Blood. 2008 Mar 1;111(5):2548-55 [18039957] Leuk Lymphoma. 2008 Jun;49(6):1142-54 [18569638] J Clin Oncol. 2008 Aug 1;26(22):3756-62 [18669463] J Clin Oncol. 2008 Aug 20;26(24):3971-8 [18711187] Lancet Oncol. 2008 Sep;9(9):873-83 [18760243] Cancer Res. 2008 Oct 1;68(19):8049-57 [18829563] Curr Oncol Rep. 2008 Nov;10(6):453-8 [18928659] Pediatr Blood Cancer. 2009 Feb;52(2):177-81 [18816698] Leukemia. 2008 Dec;22(12):2142-50 [18818707] Semin Hematol. 2009 Jan;46(1):52-63 [19100368] J Clin Oncol. 2010 Feb 1;28(4):648-54 [19841326] Curr Opin Oncol. 2013 Nov;25(6):701-6 [24097105] Leuk Lymphoma. 2014 Apr;55(4):737-48 [23841506] N Engl J Med. 2014 Oct 16;371(16):1507-17 [25317870] Clin Cancer Res. 1999 Dec;5(12):3906-13 [10632319] Clin Cancer Res. 1999 Dec;5(12):3920-7 [10632321] Br J Haematol. 2003 Nov;123(3):396-405 [14616997] Blood. 2004 Jul 1;104(1):178-83 [15001473] J Exp Med. 1986 Feb 1;163(2):347-68 [3511171] Blood. 1988 Jan;71(1):13-29 [3257143] Blood. 1990 Nov 15;76(10):1908-23 [2242419] J Immunol Methods. 1991 Feb 15;136(2):221-37 [1705571] Blood. 1991 Sep 1;78(5):1166-72 [1878583] Blood. 1992 May 15;79(10):2649-61 [1375109] Blood. 1993 Feb 1;81(3):602-9 [8427957] Br J Haematol. 1993 Nov;85(3):435-8 [8136262] Blood. 1995 Dec 1;86(11):4228-33 [7492781] Leuk Lymphoma. 1995 Aug;18(5-6):385-97 [8528044] Haematologica. 1995 Nov-Dec;80(6):546-56 [8647523] J Clin Oncol. 1999 Feb;17(2):445-55 [10080584] Leuk Lymphoma. 1999 Mar;33(1-2):101-6 [10194126] Cancer. 2005 Jan 15;103(2):368-76 [15599932] J Clin Oncol. 2006 Jul 1;24(19):3150-6 [16717292] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/CJI.0000000000000088 ER - TY - JOUR T1 - Mother's education and the risk of preterm and small for gestational age birth: a DRIVERS meta-analysis of 12 European cohorts. AN - 1703717528; 25911693 AB - A healthy start to life is a major priority in efforts to reduce health inequalities across Europe, with important implications for the health of future generations. There is limited combined evidence on inequalities in health among newborns across a range of European countries. Prospective cohort data of 75 296 newborns from 12 European countries were used. Maternal education, preterm and small for gestational age births were determined at baseline along with covariate data. Regression models were estimated within each cohort and meta-analyses were conducted to compare and measure heterogeneity between cohorts. Mother's education was linked to an appreciable risk of preterm and small for gestational age (SGA) births across 12 European countries. The excess risk of preterm births associated with low maternal education was 1.48 (1.29 to 1.69) and 1.84 (0.99 to 2.69) in relative and absolute terms (Relative/Slope Index of Inequality, RII/SII) for all cohorts combined. Similar effects were found for SGA births, but absolute inequalities were greater, with an SII score of 3.64 (1.74 to 5.54). Inequalities at birth were strong in the Netherlands, the UK, Sweden and Spain and marginal in other countries studied. This study highlights the value of comparative cohort analysis to better understand the relationship between maternal education and markers of fetal growth in different settings across Europe. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Journal of epidemiology and community health AU - Ruiz, Milagros AU - Goldblatt, Peter AU - Morrison, Joana AU - Kukla, Lubomír AU - Švancara, Jan AU - Riitta-Järvelin, Marjo AU - Taanila, Anja AU - Saurel-Cubizolles, Marie-Josèphe AU - Lioret, Sandrine AU - Bakoula, Chryssa AU - Veltsista, Alexandra AU - Porta, Daniela AU - Forastiere, Francesco AU - van Eijsden, Manon AU - Vrijkotte, Tanja G M AU - Eggesbø, Merete AU - White, Richard A AU - Barros, Henrique AU - Correia, Sofia AU - Vrijheid, Martine AU - Torrent, Maties AU - Rebagliato, Marisa AU - Larrañaga, Isabel AU - Ludvigsson, Johnny AU - Olsen Faresjö, Åshild AU - Hryhorczuk, Daniel AU - Antipkin, Youriy AU - Marmot, Michael AU - Pikhart, Hynek AD - Research Department of Epidemiology and Public Health, University College London, London, UK. ; Research Department of Epidemiology and Public Health, UCL Institute of Health Equity, University College London, London, UK. ; Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Brno, Czech Republic. ; Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Brno, Czech Republic Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic. ; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE), Centre for Environment and Health, School of Public Health, Imperial College London, London, UK Unit of Primary Care, Oulu University Hospital, Oulu, Finland Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland Institute of Health Sciences, University of Oulu, Oulu, Finland. ; Biocenter Oulu, University of Oulu, Oulu, Finland. ; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics, Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris, France. ; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1153, Early Origin of the Child's Health and Development Team (ORCHAD), Center for Epidemiology and Statistics, Sorbonne Paris Cité, Paris Descartes University, Paris, France. ; First Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece. ; Department of Epidemiology of the Lazio Regional Health System, Rome, Italy. ; Department of Epidemiology and Health Promotion, Public Health Service of Amsterdam, Amsterdam, The Netherlands. ; Department of Public Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. ; Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway. ; Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal. ; Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain. ; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain IB-Salut Menorca Health Area, Balearic Islands, Spain. ; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain Departamento de Medicina, Universitat Jaume I, Castellon, Spain. ; Public Health Department of Gipuzkoa, Gipuzkoa, Spain BIODONOSTIA Health Research Institute, San Sebastian, Spain. ; Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. ; Department of Medicine and Health Sciences, Linköping University, Linköping, Sweden. ; Center for Global Health, University of Illinois College of Medicine, Chicago, Illinois, USA. ; Institute of Pediatrics, Obstetrics, and Gynecology, Kyiv, Ukraine. ; Research Department of Epidemiology and Public Health, University College London, London, UK Research Department of Epidemiology and Public Health, UCL Institute of Health Equity, University College London, London, UK. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 826 EP - 833 VL - 69 IS - 9 KW - Index Medicus KW - INEQUALITIES KW - EPIDEMIOLOGY KW - CHILD HEALTH KW - Regression Analysis KW - Educational Status KW - Prospective Studies KW - Risk Factors KW - Humans KW - Linear Models KW - Cross-Cultural Comparison KW - Infant, Newborn KW - Europe -- epidemiology KW - Male KW - Female KW - Pregnancy KW - Pregnancy Outcome -- epidemiology KW - Mothers -- statistics & numerical data KW - Premature Birth -- epidemiology KW - Infant, Small for Gestational Age UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703717528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+epidemiology+and+community+health&rft.atitle=Mother%27s+education+and+the+risk+of+preterm+and+small+for+gestational+age+birth%3A+a+DRIVERS+meta-analysis+of+12+European+cohorts.&rft.au=Ruiz%2C+Milagros%3BGoldblatt%2C+Peter%3BMorrison%2C+Joana%3BKukla%2C+Lubom%C3%ADr%3B%C5%A0vancara%2C+Jan%3BRiitta-J%C3%A4rvelin%2C+Marjo%3BTaanila%2C+Anja%3BSaurel-Cubizolles%2C+Marie-Jos%C3%A8phe%3BLioret%2C+Sandrine%3BBakoula%2C+Chryssa%3BVeltsista%2C+Alexandra%3BPorta%2C+Daniela%3BForastiere%2C+Francesco%3Bvan+Eijsden%2C+Manon%3BVrijkotte%2C+Tanja+G+M%3BEggesb%C3%B8%2C+Merete%3BWhite%2C+Richard+A%3BBarros%2C+Henrique%3BCorreia%2C+Sofia%3BVrijheid%2C+Martine%3BTorrent%2C+Maties%3BRebagliato%2C+Marisa%3BLarra%C3%B1aga%2C+Isabel%3BLudvigsson%2C+Johnny%3BOlsen+Faresj%C3%B6%2C+%C3%85shild%3BHryhorczuk%2C+Daniel%3BAntipkin%2C+Youriy%3BMarmot%2C+Michael%3BPikhart%2C+Hynek&rft.aulast=Ruiz&rft.aufirst=Milagros&rft.date=2015-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-13 N1 - Date created - 2015-08-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Pediatr Res. 2014 Nov;76(5):418-24 [25122581] Eur J Obstet Gynecol Reprod Biol. 2003 Nov 28;111 Suppl 1:S33-44 [14642318] Cent Eur J Public Health. 2004 Sep;12(3):157-60 [15508415] Paediatr Perinat Epidemiol. 1987 Apr;1(1):43-55 [3506190] Lancet. 1993 Apr 10;341(8850):938-41 [8096277] Am J Public Health. 1994 Jun;84(6):932-7 [8203689] Obstet Gynecol. 1996 Feb;87(2):163-8 [8559516] J Health Soc Behav. 1996 Mar;37(1):104-20 [8820314] Soc Sci Med. 1997 Mar;44(6):757-71 [9080560] Paediatr Perinat Epidemiol. 1997 Jul;11(3):298-312 [9246691] Dev Med Child Neurol. 2006 Nov;48(11):906-12 [17044959] Epidemiol Prev. 2007 Nov-Dec;31(6):303-8 [18326421] N Engl J Med. 2008 Jul 3;359(1):61-73 [18596274] BMC Pediatr. 2008;8:42 [18844983] Lancet. 2008 Nov 8;372(9650):1661-9 [18994664] Br J Nutr. 2009 Feb;101(4):583-91 [18631416] Public Health Nutr. 2009 Jul;12(7):922-31 [18752697] Environ Res. 2009 Jul;109(5):559-66 [19410245] Heart. 2009 Dec;95(24):2014-22 [19822574] Bull World Health Organ. 2010 Jan;88(1):31-8 [20428351] Eur Respir J. 2001 Aug;18(2):323-9 [11529291] Int J Epidemiol. 2012 Aug;41(4):930-40 [21471022] J Child Neurol. 2011 Feb;26(2):199-204 [20921568] Int J Epidemiol. 2011 Oct;40(5):1176-86 [20813863] Comment In: J Epidemiol Community Health. 2015 Sep;69(9):821-2 [25858637] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/jech-2014-205387 ER - TY - CONF T1 - Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute. AN - 1703245099; 26134581 AB - Recent technological advances have led to rapid progress in the characterization of epigenetic modifications that control gene expression in a generally heritable way, and are likely involved in defining cellular phenotypes, developmental stages and disease status from one generation to the next. On November 18, 2013, the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) held a symposium entitled "Advances in Assessing Adverse Epigenetic Effects of Drugs and Chemicals" in Washington, D.C. The goal of the symposium was to identify gaps in knowledge and highlight promising areas of progress that represent opportunities to utilize epigenomic profiling for risk assessment of drugs and chemicals. Epigenomic profiling has the potential to provide mechanistic information in toxicological safety assessments; this is especially relevant for the evaluation of carcinogenic or teratogenic potential and also for drugs that directly target epigenetic modifiers, like DNA methyltransferases or histone modifying enzymes. Furthermore, it can serve as an endpoint or marker for hazard characterization in chemical safety assessment. The assessment of epigenetic effects may also be approached with new model systems that could directly assess transgenerational effects or potentially sensitive stem cell populations. These would enhance the range of safety assessment tools for evaluating xenobiotics that perturb the epigenome. Here we provide a brief synopsis of the symposium, update findings since that time and then highlight potential directions for future collaborative efforts to incorporate epigenetic profiling into risk assessment. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology AU - Miousse, Isabelle R AU - Currie, Richard AU - Datta, Kaushik AU - Ellinger-Ziegelbauer, Heidrun AU - French, John E AU - Harrill, Alison H AU - Koturbash, Igor AU - Lawton, Michael AU - Mann, Derek AU - Meehan, Richard R AU - Moggs, Jonathan G AU - O'Lone, Raegan AU - Rasoulpour, Reza J AU - Pera, Renee A Reijo AU - Thompson, Karol Y1 - 2015/09/01/ PY - 2015 DA - 2015 Sep 01 SP - 11 EP - 19 VL - 335 KW - Genetic Markers KW - 0 KW - Index Medicus KW - Stem cells KW - Transgenerational effects KW - Epigenetics KW - Biomarkers KW - Safety assessment KW - Models KW - Stem Cells -- drug effects KW - Animals KW - Cellular Reprogramming -- drug effects KW - Endpoint Determination KW - Dose-Response Relationship, Drug KW - Humans KW - DNA Methylation -- drug effects KW - Stem Cells -- pathology KW - Environmental Monitoring -- standards KW - Gene Expression Regulation, Developmental -- drug effects KW - Risk Assessment KW - Epigenesis, Genetic -- drug effects KW - Toxicity Tests -- standards KW - Gene Expression Profiling -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703245099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Toxicology&rft.atitle=Importance+of+investigating+epigenetic+alterations+for+industry+and+regulators%3A+An+appraisal+of+current+efforts+by+the+Health+and+Environmental+Sciences+Institute.&rft.au=Miousse%2C+Isabelle+R%3BCurrie%2C+Richard%3BDatta%2C+Kaushik%3BEllinger-Ziegelbauer%2C+Heidrun%3BFrench%2C+John+E%3BHarrill%2C+Alison+H%3BKoturbash%2C+Igor%3BLawton%2C+Michael%3BMann%2C+Derek%3BMeehan%2C+Richard+R%3BMoggs%2C+Jonathan+G%3BO%27Lone%2C+Raegan%3BRasoulpour%2C+Reza+J%3BPera%2C+Renee+A+Reijo%3BThompson%2C+Karol&rft.aulast=Miousse&rft.aufirst=Isabelle&rft.date=2015-09-01&rft.volume=335&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.06.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-28 N1 - Date created - 2015-08-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.06.009 ER - TY - JOUR T1 - Targeting of IL-4 and IL-13 receptors for cancer therapy. AN - 1703239604; 26088753 AB - The Th2 cytokines, interleukin (IL)-4 and -13, are structurally and functionally related. They regulate immune responses and the immune microenvironment, not only under normal physiological conditions, but also in cancer. Both cytokines bind to their high-affinity receptors and form various configurations of receptor subtypes. We and others have reported that IL-4 and IL-13 bind to IL-4Rα and IL-13Rα1 chains, forming functional receptors in cancer cells. IL-13 also binds with high affinity to a private chain IL-13Rα2. After forming ligand-receptor complexes, both cytokines initiate signal transduction and mediate biological effects, such as tumor proliferation, cell survival, cell adhesion and metastasis. In certain cancers, the presence of these cytokine receptors may serve as biomarkers of cancer aggressiveness. In a series of studies, we reported that overexpression of IL-4 and IL-13 receptors on cancer cells provides targets for therapeutic agents for cancer therapy. In addition, both of these cytokines and their receptors have been shown to play important roles in modulating the immune system for tumor growth. IL-4, IL-13 and their receptors seem to play a role in cancer stem cells and provide unique targets to eradicate these cells. In this review article, we summarize some of the important attributes of IL-4 and IL-13 receptors in cancer biology and discuss pre-clinical and clinical studies pertaining to recombinant immunotoxins designed to target these receptors. Published by Elsevier Ltd. JF - Cytokine AU - Suzuki, Akiko AU - Leland, Pamela AU - Joshi, Bharat H AU - Puri, Raj K AD - Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States. Electronic address: akiko.suzuki@fda.hhs.gov. ; Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States. Electronic address: pamela.dover@fda.hhs.gov. ; Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States. Electronic address: bharat.joshi@fda.hhs.gov. ; Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States. Electronic address: raj.puri@fda.hhs.gov. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 79 EP - 88 VL - 75 IS - 1 KW - Antibodies, Monoclonal KW - 0 KW - Antigens KW - Antineoplastic Agents KW - Biomarkers, Tumor KW - IL4R protein, human KW - Immunotoxins KW - Interleukin-13 Receptor alpha2 Subunit KW - Interleukin-4 Receptor alpha Subunit KW - Receptors, Interleukin-13 KW - interleukin-13 receptor, human KW - liposomal doxorubicin KW - Polyethylene Glycols KW - 30IQX730WE KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Interleukin-13 KW - Receptor-targeted cancer therapy KW - Interleukin-4 KW - Interleukin-13 receptor KW - Interleukin-4 receptor KW - Animals KW - Doxorubicin -- analogs & derivatives KW - Doxorubicin -- chemistry KW - Humans KW - Disease Models, Animal KW - Mice KW - Cell Proliferation KW - Antibodies, Monoclonal -- immunology KW - Cell Survival KW - Immunotherapy -- methods KW - Immunotoxins -- chemistry KW - Biomarkers, Tumor -- metabolism KW - Interleukin-13 Receptor alpha2 Subunit -- metabolism KW - Polyethylene Glycols -- chemistry KW - Neoplasm Metastasis KW - Antigens -- immunology KW - Cell Adhesion KW - Gene Expression Regulation, Neoplastic KW - Receptors, Interleukin-13 -- metabolism KW - Interleukin-4 Receptor alpha Subunit -- metabolism KW - Antineoplastic Agents -- therapeutic use KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703239604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Targeting+of+IL-4+and+IL-13+receptors+for+cancer+therapy.&rft.au=Suzuki%2C+Akiko%3BLeland%2C+Pamela%3BJoshi%2C+Bharat+H%3BPuri%2C+Raj+K&rft.aulast=Suzuki&rft.aufirst=Akiko&rft.date=2015-09-01&rft.volume=75&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=1096-0023&rft_id=info:doi/10.1016%2Fj.cyto.2015.05.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-06 N1 - Date created - 2015-08-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cyto.2015.05.026 ER - TY - JOUR T1 - Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles. AN - 1700106209; 26217770 AB - High mortality rates are associated with the life threatening disease of sepsis. Improvements in septic patient survivability have failed to materialize with currently available treatments. This article represents data regarding a study published in biomaterials (Vellaisamy et al., Biomaterials, 2015, in press). with the purpose of evaluating whether severe sepsis mortality and associated hepatic dysfunction induced by lipopolysaccharide (LPS) can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the method and processing of raw data related to our study publish in Biomaterials and Data in Brief (Vellaisamy et al., Biomaterials, 2015, in press; Vellaisamy et al., Data in Brief, 2015, in press.). The data contained in this article evaluates the contribution of MAPK signaling in LPS induced sepsis. Macrophage cells (RAW 264.7) were treated with a range of cerium oxide nanoparticle concentration in the presence and absence of LPS. Immunoblotting was performed on the cell lysates to evaluate the effect of cerium oxide nanoparticle treatment on LPS induced changes in Mitogen Activated Protein Kinases (MAPK) p-38, ERK 1/2, and SAPK/JNK phosphorylation. JF - Data in brief AU - Selvaraj, Vellaisamy AU - Nepal, Niraj AU - Rogers, Steven AU - Manne, Nandini D P K AU - Arvapalli, Ravikumar AU - Rice, Kevin M AU - Asano, Shinichi AU - Fankenhanel, Erin AU - Ma, J Y AU - Shokuhfar, Tolou AU - Maheshwari, Mani AU - Blough, Eric R AD - Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA. ; Health Effects Laboratory Division, NIOSH, Morgantown, WV, USA. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, USA. ; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA ; Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA ; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA ; Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 96 EP - 99 VL - 4 KW - MAPK KW - Sepsis KW - Raw 264.7 cells KW - LPS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700106209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Data+in+brief&rft.atitle=Lipopolysaccharide+induced+MAP+kinase+activation+in+RAW+264.7+cells+attenuated+by+cerium+oxide+nanoparticles.&rft.au=Selvaraj%2C+Vellaisamy%3BNepal%2C+Niraj%3BRogers%2C+Steven%3BManne%2C+Nandini+D+P+K%3BArvapalli%2C+Ravikumar%3BRice%2C+Kevin+M%3BAsano%2C+Shinichi%3BFankenhanel%2C+Erin%3BMa%2C+J+Y%3BShokuhfar%2C+Tolou%3BMaheshwari%2C+Mani%3BBlough%2C+Eric+R&rft.aulast=Selvaraj&rft.aufirst=Vellaisamy&rft.date=2015-09-01&rft.volume=4&rft.issue=&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Data+in+brief&rft.issn=&rft_id=info:doi/10.1016%2Fj.dib.2015.04.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-28 N1 - Date created - 2015-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.dib.2015.04.022 ER - TY - JOUR T1 - Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis. AN - 1700104821; 26217772 AB - The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of cerium oxide nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of cerium oxide nanoparticle demonstrate that concentration of cerium oxide nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay. JF - Data in brief AU - Selvaraj, Vellaisamy AU - Nepal, Niraj AU - Rogers, Steven AU - Manne, Nandini D P K AU - Arvapalli, Ravikumar AU - Rice, Kevin M AU - Asano, Shinichi AU - Fankenhanel, Erin AU - Ma, J Y AU - Shokuhfar, Tolou AU - Maheshwari, Mani AU - Blough, Eric R AD - Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA. ; Health Effects Laboratory Division, NIOSH, Morgantown, WV, USA. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, USA. ; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA ; Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA ; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA ; Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 105 EP - 115 VL - 4 KW - MTT KW - Sepsis KW - LPS KW - Sprague Dawley rat KW - Raw 264.7 KW - Cerium oxide nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700104821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Data+in+brief&rft.atitle=Cerium+oxide+nanoparticles+inhibit+lipopolysaccharide+induced+MAP+kinase%2FNF-kB+mediated+severe+sepsis.&rft.au=Selvaraj%2C+Vellaisamy%3BNepal%2C+Niraj%3BRogers%2C+Steven%3BManne%2C+Nandini+D+P+K%3BArvapalli%2C+Ravikumar%3BRice%2C+Kevin+M%3BAsano%2C+Shinichi%3BFankenhanel%2C+Erin%3BMa%2C+J+Y%3BShokuhfar%2C+Tolou%3BMaheshwari%2C+Mani%3BBlough%2C+Eric+R&rft.aulast=Selvaraj&rft.aufirst=Vellaisamy&rft.date=2015-09-01&rft.volume=4&rft.issue=&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Data+in+brief&rft.issn=&rft_id=info:doi/10.1016%2Fj.dib.2015.04.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-28 N1 - Date created - 2015-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.dib.2015.04.023 ER - TY - JOUR T1 - 24-hour human urine and serum profiles of bisphenol A following ingestion in soup: Individual pharmacokinetic data and emographics. AN - 1700104724; 26217767 AB - Here we present data to evaluate potential absorption of Bisphenol A through non-metabolizing tissues of the upper digestive tract. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a 24 h period in 10 adult male volunteers following ingestion of 30 μg d6-BPA/kg body weight in soup. The pharmacokinetic behavior of BPA and its metabolites in this cohort (rapid absorption, complete elimination, evidence against sublingual absorption) was reported. This Data in Brief article contains the corresponding individual pharmacokinetic data, reports the demographics of the cohort and provides additional details related to the analytical methods employed and is related to [4]. JF - Data in brief AU - Teeguarden, Justin G AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Yang, Xiaoxia AU - Fisher, Jeffrey W AU - Seryak, Liesel M AU - Doerge, Daniel R AD - Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99352, USA ; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 93771, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH 43210, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 83 EP - 86 VL - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700104724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=A+Phase+1+Randomized%2C+Blinded+Comparison+of+the+Pharmacokinetics+and+Colonic+Distribution+of+Three+Candidate+Rectal+Microbicide+Formulations+of+Tenofovir+1%25+Gel+with+Simulated+Unprotected+Sex+%28CHARM-02%29.&rft.au=Hiruy%2C+Hiwot%3BFuchs%2C+Edward+J%3BMarzinke%2C+Mark+A%3BBakshi%2C+Rahul+P%3BBreakey%2C+Jennifer+C%3BAung%2C+Wutyi+S%3BManohar%2C+Madhuri%3BYue%2C+Chen%3BCaffo%2C+Brian+S%3BDu%2C+Yong%3BAbebe%2C+Kaleab+Z%3BSpiegel%2C+Hans+M+L%3BRohan%2C+Lisa+C%3BMcGowan%2C+Ian%3BHendrix%2C+Craig+W&rft.aulast=Hiruy&rft.aufirst=Hiwot&rft.date=2015-11-01&rft.volume=31&rft.issue=11&rft.spage=1098&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=1931-8405&rft_id=info:doi/10.1089%2FAID.2015.0098 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-28 N1 - Date created - 2015-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.dib.2015.03.002 ER - TY - JOUR T1 - Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation. AN - 1700104641; 26217789 AB - Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro model based on the differentiation of mouse embryonic stem cells (mESCs), and published the major findings in a research article entitled "Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells" [1]. The data presented herein contains complementary information related to the aforementioned research article. JF - Data in brief AU - Gao, Xiugong AU - Sprando, Robert L AU - Yourick, Jeffrey J AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 199 EP - 202 VL - 4 KW - Differentiation KW - Microarray KW - Transcriptomics KW - Thalidomide KW - Developmental toxicity KW - Mouse KW - Embryonic stem cell UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700104641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Data+in+brief&rft.atitle=Transcriptomic+changes+in+mouse+embryonic+stem+cells+exposed+to+thalidomide+during+spontaneous+differentiation.&rft.au=Gao%2C+Xiugong%3BSprando%2C+Robert+L%3BYourick%2C+Jeffrey+J&rft.aulast=Gao&rft.aufirst=Xiugong&rft.date=2015-09-01&rft.volume=4&rft.issue=&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Data+in+brief&rft.issn=&rft_id=info:doi/10.1016%2Fj.dib.2015.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-28 N1 - Date created - 2015-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.dib.2015.05.014 ER - TY - JOUR T1 - Mammalian gastrointestinal tract parameters modulating the integrity, surface properties, and absorption of food-relevant nanomaterials. AN - 1698967798; 25641962 AB - Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid-based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food-relevant engineered NMs for risk assessment. © 2015 The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley Periodicals, Inc. JF - Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology AU - Bellmann, Susann AU - Carlander, David AU - Fasano, Alessio AU - Momcilovic, Dragan AU - Scimeca, Joseph A AU - Waldman, W James AU - Gombau, Lourdes AU - Tsytsikova, Lyubov AU - Canady, Richard AU - Pereira, Dora I A AU - Lefebvre, David E AD - TNO, Utrecht, The Netherlands. ; Nanotechnology Industries Association, Brussels, Belgium. ; Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA. ; Department of Health and Human Services, US Food and Drug Administration, Silver Spring, MD, USA. ; Cargill, Incorporated, Minneapolis, MN, USA. ; Ohio State University, Columbus, OH, USA. ; Leitat Technological Center, Barcelona, Spain. ; Center for Risk Science Innovation and Application, ILSI Research Foundation, Washington, DC, USA. ; MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK. ; Regulatory Toxicology Research Division, Food Directorate, Health Canada, Ottawa, Canada. PY - 2015 SP - 609 EP - 622 VL - 7 IS - 5 KW - Index Medicus KW - Animals KW - Humans KW - Surface Properties KW - Gastrointestinal Tract -- physiology KW - Nanostructures -- chemistry KW - Food KW - Mammals -- physiology KW - Intestinal Absorption UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698967798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.atitle=Mammalian+gastrointestinal+tract+parameters+modulating+the+integrity%2C+surface+properties%2C+and+absorption+of+food-relevant+nanomaterials.&rft.au=Bellmann%2C+Susann%3BCarlander%2C+David%3BFasano%2C+Alessio%3BMomcilovic%2C+Dragan%3BScimeca%2C+Joseph+A%3BWaldman%2C+W+James%3BGombau%2C+Lourdes%3BTsytsikova%2C+Lyubov%3BCanady%2C+Richard%3BPereira%2C+Dora+I+A%3BLefebvre%2C+David+E&rft.aulast=Bellmann&rft.aufirst=Susann&rft.date=2015-09-01&rft.volume=7&rft.issue=5&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.issn=1939-0041&rft_id=info:doi/10.1002%2Fwnan.1333 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-25 N1 - Date created - 2015-07-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/wnan.1333 ER - TY - JOUR T1 - Identification of pathway-based toxicity in the BALB/c 3T3 cell model. AN - 1689623569; 25450744 AB - The particulate matter represents one of the most complex environmental mixtures, whose effects on human health and environment vary according to particles characteristics and source of emissions. The present study describes an integrated approach, including in vitro tests and toxicogenomics, to highlight the effects of air particulate matter on toxicological relevant endpoints. Air samples (PM2.5) were collected in summer and winter at different sites, representative of different levels of air pollution. Samples organic extracts were tested in the BALB/c 3T3 CTA at a dose range 1-12m(3). The effect of the exposure to the samples at a dose of 8m(3) on the whole-genome transcriptomic profile was also assessed. All the collected samples induced dose-related toxic effects in the exposed cells. The modulated gene pathways confirmed that toxicity was related to sampling season and sampling site. The analysis of the KEGG's pathways showed modulation of several gene networks related to oxidative stress and inflammation. Even if the samples did not induce cell transformation in the treated cells, gene pathways related to the onset of cancer were modulated as a consequence of the exposure. This integrated approach could provide valuable information for predicting toxic risks in humans exposed to air pollution. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Vaccari, Monica AU - Mascolo, Maria Grazia AU - Rotondo, Francesca AU - Morandi, Elena AU - Quercioli, Daniele AU - Perdichizzi, Stefania AU - Zanzi, Cristina AU - Serra, Stefania AU - Poluzzi, Vanes AU - Angelini, Paola AU - Grilli, Sandro AU - Colacci, Annamaria AD - Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy. Electronic address: monica.vaccari4@unibo.it. ; Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy. ; Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy; Interdepartmental Center for Cancer Research "G. Prodi", University of Bologna, Italy. ; Department of Experimental, Diagnostic and Specialty Medicine-Cancer Research Section, University of Bologna, Italy. ; Center for Urban Areas, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy. ; Public Health Service, Emilia-Romagna Region, Bologna, Italy. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 1240 EP - 1253 VL - 29 IS - 6 KW - Air Pollutants KW - 0 KW - Particulate Matter KW - Index Medicus KW - Gene expression KW - Pathway-based toxicity KW - Environmental mixtures KW - Particulate matter KW - Cell transformation assay KW - Gene Expression -- drug effects KW - Gene Expression Profiling KW - Animals KW - Cell Survival -- drug effects KW - BALB 3T3 Cells KW - Microarray Analysis KW - Mice KW - Particulate Matter -- toxicity KW - Air Pollutants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689623569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Identification+of+pathway-based+toxicity+in+the+BALB%2Fc+3T3+cell+model.&rft.au=Vaccari%2C+Monica%3BMascolo%2C+Maria+Grazia%3BRotondo%2C+Francesca%3BMorandi%2C+Elena%3BQuercioli%2C+Daniele%3BPerdichizzi%2C+Stefania%3BZanzi%2C+Cristina%3BSerra%2C+Stefania%3BPoluzzi%2C+Vanes%3BAngelini%2C+Paola%3BGrilli%2C+Sandro%3BColacci%2C+Annamaria&rft.aulast=Vaccari&rft.aufirst=Monica&rft.date=2015-09-01&rft.volume=29&rft.issue=6&rft.spage=1240&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2014.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-07 N1 - Date created - 2015-06-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2014.10.002 ER - TY - JOUR T1 - Inhibition of prolactin with bromocriptine for 28days increases blood-brain barrier permeability in the rat. AN - 1697211634; 26047726 AB - The blood-brain barrier (BBB) is necessary for the proper function of the brain. Its maintenance is regulated by endogenous factors. Recent evidences suggest prolactin (PRL) regulates the BBB properties in vitro, nevertheless no evidence of these effects have been reported in vivo. The aim of this study was to evaluate the role of PRL in the maintenance of the BBB in the rat. Male Wistar rats were treated with Bromocriptine (Bromo) to inhibit PRL production for 28days in the absence or presence of lipopolysaccharide (LPS). BBB permeability was evaluated through the Evans Blue dye and fluorescein-dextran extravasation as well as through edema formation. The expression of claudin-5, occludin, glial fibrillary acidic protein (GFAP) and the PRL receptor (PRLR) was evaluated through western blot. Bromo reduced the physiological levels of PRL at 28days. At the same time, Bromo increased BBB permeability and edema formation associated with a decrement in claudin-5 and occludin and potentiated the increase in BBB permeability induced by LPS. However, no neuroinflammation was detected, since the expression of GFAP was unchanged, as well as the expression of the PRLR. These data provide the first evidence that inhibition of PRL with Bromo affects the maintenance of the BBB through modulating the expression of tight junction proteins in vivo. Copyright © 2015 IBRO. All rights reserved. JF - Neuroscience AU - Rosas-Hernandez, H AU - Ramirez, M AU - Ramirez-Lee, M A AU - Ali, S F AU - Gonzalez, C AD - Laboratorio de Fisiologia Celular, Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava 6, Colonia Universitaria, San Luis Potosi, SLP 78210, Mexico. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Laboratorio de Fisiologia Celular, Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava 6, Colonia Universitaria, San Luis Potosi, SLP 78210, Mexico. Electronic address: cgonzalez.uaslp@gmail.com. Y1 - 2015/08/20/ PY - 2015 DA - 2015 Aug 20 SP - 61 EP - 70 VL - 301 KW - Claudin-5 KW - 0 KW - Cldn5 protein, rat KW - Dopamine Agonists KW - Hormone Antagonists KW - Occludin KW - Ocln protein, rat KW - Bromocriptine KW - 3A64E3G5ZO KW - Prolactin KW - 9002-62-4 KW - Index Medicus KW - blood–brain barrier KW - prolactin KW - lipopolysaccharide KW - tight junctions KW - permeability KW - Rats KW - Animals KW - Brain Edema -- metabolism KW - Dopamine Agonists -- pharmacology KW - Claudin-5 -- metabolism KW - Rats, Wistar KW - Bromocriptine -- pharmacology KW - Occludin -- metabolism KW - Male KW - Hormone Antagonists -- pharmacology KW - Blood-Brain Barrier -- metabolism KW - Capillary Permeability KW - Prolactin -- antagonists & inhibitors KW - Prolactin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697211634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Inhibition+of+prolactin+with+bromocriptine+for+28days+increases+blood-brain+barrier+permeability+in+the+rat.&rft.au=Rosas-Hernandez%2C+H%3BRamirez%2C+M%3BRamirez-Lee%2C+M+A%3BAli%2C+S+F%3BGonzalez%2C+C&rft.aulast=Rosas-Hernandez&rft.aufirst=H&rft.date=2015-08-20&rft.volume=301&rft.issue=&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=1873-7544&rft_id=info:doi/10.1016%2Fj.neuroscience.2015.05.066 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-18 N1 - Date created - 2015-07-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuroscience.2015.05.066 ER - TY - JOUR T1 - FDA Approval: Ibrutinib for Patients with Previously Treated Mantle Cell Lymphoma and Previously Treated Chronic Lymphocytic Leukemia AN - 1808618284; PQ0003450511 AB - On November 13, 2013, the FDA granted accelerated approval to ibrutinib (IMBRUVICA capsules; Pharmacyclics, Inc.) for the treatment of patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. On February 12, 2014, the FDA granted accelerated approval for the treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one prior therapy. Ibrutinib is a first-in-class Bruton's tyrosine kinase (BTK) inhibitor that received all four expedited programs of the FDA: Fast-Track designation, Breakthrough Therapy designation, Priority Review, and Accelerated Approval. Both approvals were based on overall response rate (ORR) and duration of response (DOR) in single-arm clinical trials in patients with prior treatment. In MCL (N = 111), the complete and partial response rates were 17.1% and 48.6%, respectively, for an ORR of 65.8% [95% confidence interval (CI), 56.2%-74.5%]. The median DOR was 17.5 months (95% CI, 15.8-not reached). In CLL (N = 48), the ORR was 58.3% (95% CI, 43.2%-72.4%), and the DOR ranged from 5.6 to 24.2 months. The most common adverse reactions ( greater than or equal to 30% in either trial) were thrombocytopenia, diarrhea, neutropenia, bruising, upper respiratory tract infection, anemia, fatigue, musculoskeletal pain, peripheral edema, and nausea. Clin Cancer Res; 21(16); 3586-90. copyright 2015 AACR. JF - Clinical Cancer Research AU - de Claro, RAngelo AU - McGinn, Karen M AU - Verdun, Nicole AU - Lee, Shwu-Luan AU - Chiu, Haw-Jyh AU - Saber, Haleh AU - Brower, Margaret E AU - Chang, CJGeorge AU - Pfuma, Elimika AU - Habtemariam, Bahru AU - Bullock, Julie AU - Wang, Yun AU - Nie, Lei AU - Chen, Xiao-Hong AU - Lu, Donghao AU - Al-Hakim, Ali AU - Kane, Robert C AU - Kaminskas, Edvardas AU - Justice, Robert AU - Farrell, Ann T AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, romeo.declaro@fda.hhs.gov Y1 - 2015/08/15/ PY - 2015 DA - 2015 Aug 15 SP - 3586 EP - 3590 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 21 IS - 16 SN - 1078-0432, 1078-0432 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Fatigue KW - Diarrhea KW - Anemia KW - Edema KW - Pain KW - Clinical trials KW - Cancer KW - Neutropenia KW - Respiratory tract diseases KW - mantle cell lymphoma KW - Thrombocytopenia KW - Nausea KW - Chronic lymphatic leukemia KW - Side effects KW - Bruton's tyrosine kinase KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808618284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=FDA+Approval%3A+Ibrutinib+for+Patients+with+Previously+Treated+Mantle+Cell+Lymphoma+and+Previously+Treated+Chronic+Lymphocytic+Leukemia&rft.au=de+Claro%2C+RAngelo%3BMcGinn%2C+Karen+M%3BVerdun%2C+Nicole%3BLee%2C+Shwu-Luan%3BChiu%2C+Haw-Jyh%3BSaber%2C+Haleh%3BBrower%2C+Margaret+E%3BChang%2C+CJGeorge%3BPfuma%2C+Elimika%3BHabtemariam%2C+Bahru%3BBullock%2C+Julie%3BWang%2C+Yun%3BNie%2C+Lei%3BChen%2C+Xiao-Hong%3BLu%2C+Donghao%3BAl-Hakim%2C+Ali%3BKane%2C+Robert+C%3BKaminskas%2C+Edvardas%3BJustice%2C+Robert%3BFarrell%2C+Ann+T%3BPazdur%2C+Richard&rft.aulast=de+Claro&rft.aufirst=RAngelo&rft.date=2015-08-15&rft.volume=21&rft.issue=16&rft.spage=3586&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-2225 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Diarrhea; Fatigue; Anemia; Edema; Pain; Clinical trials; Cancer; Respiratory tract diseases; Neutropenia; mantle cell lymphoma; Thrombocytopenia; Nausea; Chronic lymphatic leukemia; Bruton's tyrosine kinase; Side effects DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-2225 ER - TY - JOUR T1 - Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells. AN - 1693711060; 26006729 AB - Developmental toxicity testing has traditionally relied on animal models which are costly, time consuming, and require the sacrifice of large numbers of animals. In addition, there are significant disparities between human beings and animals in their responses to chemicals. Thalidomide is a species-specific developmental toxicant that causes severe limb malformations in humans but not in mice. Here, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro model based on differentiation of mouse embryonic stem cells (mESCs). C57BL/6 mESCs were allowed to differentiate spontaneously and RNA was collected at 24, 48, and 72h after exposure to 0.25mM thalidomide. Global gene expression analysis using microarrays revealed hundreds of differentially expressed genes upon thalidomide exposure that were enriched in gene ontology (GO) terms and canonical pathways associated with embryonic development and differentiation. In addition, many genes were found to be involved in small GTPases-mediated signal transduction, heart development, and inflammatory responses, which coincide with clinical evidences and may represent critical embryotoxicities of thalidomide. These results demonstrate that transcriptomics in combination with mouse embryonic stem cell differentiation is a promising alternative model for developmental toxicity assessment. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Gao, Xiugong AU - Sprando, Robert L AU - Yourick, Jeffrey J AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, United States. Electronic address: xiugong.gao@fda.hhs.gov. ; Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, United States. Y1 - 2015/08/15/ PY - 2015 DA - 2015 Aug 15 SP - 43 EP - 51 VL - 287 IS - 1 KW - Thalidomide KW - 4Z8R6ORS6L KW - Index Medicus KW - Differentiation KW - Microarray KW - Transcriptomics KW - Developmental toxicity KW - Mouse KW - Embryonic stem cell KW - Real-Time Polymerase Chain Reaction KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Gene Regulatory Networks -- drug effects KW - Humans KW - Gene Expression Profiling -- methods KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Toxicity Tests -- methods KW - Toxicogenetics -- methods KW - Species Specificity KW - Time Factors KW - Transcriptome -- drug effects KW - Pluripotent Stem Cells -- drug effects KW - Embryonic Stem Cells -- metabolism KW - Embryonic Stem Cells -- drug effects KW - Pluripotent Stem Cells -- pathology KW - Thalidomide -- toxicity KW - Embryonic Stem Cells -- pathology KW - Gene Expression Regulation, Developmental -- drug effects KW - Pluripotent Stem Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1693711060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Thalidomide+induced+early+gene+expression+perturbations+indicative+of+human+embryopathy+in+mouse+embryonic+stem+cells.&rft.au=Gao%2C+Xiugong%3BSprando%2C+Robert+L%3BYourick%2C+Jeffrey+J&rft.aulast=Gao&rft.aufirst=Xiugong&rft.date=2015-08-15&rft.volume=287&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.05.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-14 N1 - Date created - 2015-07-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.05.009 ER - TY - JOUR T1 - The time to most recent common ancestor does not (usually) approximate the date of divergence AN - 1734270907; 2015-112673 AB - With the advent of more sophisticated models and increase in computational power, an ever-growing amount of information can be extracted from DNA sequence data. In particular, recent advances have allowed researchers to estimate the date of historical events for a group of interest including time to most recent common ancestor (TMRCA), dates of specific nodes in a phylogeny, and the date of divergence or speciation date. Here I use coalescent simulations and re-analyze an empirical dataset to illustrate the importance of taxon sampling, in particular, on correctly estimating such dates. I show that TMRCA of representatives of a single taxon is often not the same as divergence date due to issues such as incomplete lineage sorting. Of critical importance is when estimating divergence or speciation dates a representative from a different taxonomic lineage must be included in the analysis. Without considering these issues, studies may incorrectly estimate the times at which historical events occurred, which has profound impacts within both research and applied (e.g., those related to public health) settings. JF - PLoS One AU - Pettengill, James B Y1 - 2015/08/14/ PY - 2015 DA - 2015 Aug 14 PB - Public Library of Science, San Francisco, CA VL - 2015 IS - e0128407 KW - methods KW - Quaternary KW - living taxa KW - phylogeny KW - biologic evolution KW - molecular clocks KW - coalescent simulations KW - upper Pleistocene KW - genetics KW - Cenozoic KW - nucleic acids KW - speciation KW - Salmonella enterica KW - bacteria KW - DNA KW - Pleistocene KW - 09:Paleobotany UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734270907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=The+time+to+most+recent+common+ancestor+does+not+%28usually%29+approximate+the+date+of+divergence&rft.au=Pettengill%2C+James+B&rft.aulast=Pettengill&rft.aufirst=James&rft.date=2015-08-14&rft.volume=2015&rft.issue=e0128407&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0128407 L2 - http://journals.plos.org/plosone/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2015-01-01 N1 - Number of references - 14 N1 - PubXState - CA N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2016-09-16 N1 - SubjectsTermNotLitGenreText - bacteria; biologic evolution; Cenozoic; coalescent simulations; DNA; genetics; living taxa; methods; molecular clocks; nucleic acids; phylogeny; Pleistocene; Quaternary; Salmonella enterica; speciation; upper Pleistocene DO - http://dx.doi.org/10.1371/journal.pone.0128407 ER - TY - JOUR T1 - Draft Genome Sequence of Multidrug-Resistant Enterococcus faecium Clinical Isolate VRE3, with a Sequence Type 16 Pattern and Novel Structural Arrangement of Tn1546. AN - 1704354662; 26272564 AB - Multidrug-resistant Enterococcus faecium has emerged as a nosocomial pathogen that may infect the body at various sites, including the gastrointestinal tract, and has serious implications in human health and disease. Here, we present the draft genome sequence of clinical strain VRE3, which exhibited a sequence type 16 (ST16) pattern and carried truncated Tn1546, a mobile genetic element encoding a high level of vancomycin resistance. Copyright © 2015 Khan et al. JF - Genome announcements AU - Khan, Saeed AU - Sung, Kidon AU - Marasa, Bernard AU - Min, Seonggi AU - Kweon, Ohgew AU - Nawaz, Mohamed AU - Cerniglia, Carl AD - Division of Microbiology, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration, Jefferson, Arkansas, USA saeed.khan@fda.hhs.gov. ; Division of Microbiology, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration, Jefferson, Arkansas, USA. ; Division of Microbiological Assessment, Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ; Office of Scientific Coordination, NCTR, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. Y1 - 2015/08/13/ PY - 2015 DA - 2015 Aug 13 VL - 3 IS - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704354662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+announcements&rft.atitle=Draft+Genome+Sequence+of+Multidrug-Resistant+Enterococcus+faecium+Clinical+Isolate+VRE3%2C+with+a+Sequence+Type+16+Pattern+and+Novel+Structural+Arrangement+of+Tn1546.&rft.au=Khan%2C+Saeed%3BSung%2C+Kidon%3BMarasa%2C+Bernard%3BMin%2C+Seonggi%3BKweon%2C+Ohgew%3BNawaz%2C+Mohamed%3BCerniglia%2C+Carl&rft.aulast=Khan&rft.aufirst=Saeed&rft.date=2015-08-13&rft.volume=3&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genome+announcements&rft.issn=&rft_id=info:doi/10.1128%2FgenomeA.00871-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-14 N1 - Date created - 2015-08-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/genomeA.00871-15 ER - TY - JOUR T1 - Composition Directed Generation of Reactive Oxygen Species in Irradiated Mixed Metal Sulfides Correlated with Their Photocatalytic Activities. AN - 1702091476; 26158231 AB - The ability of nanostructures to facilitate the generation of reactive oxygen species and charge carriers underlies many of their chemical and biological activities. Elucidating which factors are essential and how these influence the production of various active intermediates is fundamental to understanding potential applications of these nanostructures, as well as potential risks. Using electron spin resonance spectroscopy coupled with spin trapping and spin labeling techniques, we assessed 3 mixed metal sulfides of varying compositions for their abilities to generate reactive oxygen species, photogenerate electrons, and consume oxygen during photoirradiation. We found these irradiated mixed metal sulfides exhibited composition dependent generation of ROS: ZnIn2S4 can generate (•)OH, O2(-•) and (1)O2; CdIn2S4 can produce O2(-•) and (1)O2, while AgInS2 only produces O2(-•). Our characterizations of the reactivity of the photogenerated electrons and consumption of dissolved oxygen, performed using spin labeling, showed the same trend in activity: ZnIn2S4 > CdIn2S4 > AgInS2. These intrinsic abilities to generate ROS and the reactivity of charge carriers correlated closely with the photocatalytic degradation and photoassisted antibacterial activities of these nanomaterials. JF - ACS applied materials & interfaces AU - He, Weiwei AU - Jia, Huimin AU - Yang, Dongfang AU - Xiao, Pin AU - Fan, Xiaoli AU - Zheng, Zhi AU - Kim, Hyun-Kyung AU - Wamer, Wayne G AU - Yin, Jun-Jie AD - †Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, Xuchang University, Xuchang, Henan 461000, P. R. China. ; §School of Materials Science and Engineering, State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China. ; ∥Food Safety Bureau, Ministry of Food and Drug Safety, Osong Health Technology Administration Complex 363-700, Republic of Korea. ; ‡Division of Bioanalytical Chemistry and Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, United States. Y1 - 2015/08/05/ PY - 2015 DA - 2015 Aug 05 SP - 16440 EP - 16449 VL - 7 IS - 30 KW - Reactive Oxygen Species KW - 0 KW - Sulfides KW - Index Medicus KW - photocatalytic KW - reactive oxygen species KW - ESR KW - mixed metal sulfides KW - antibacterial KW - Catalysis -- radiation effects KW - Light KW - Statistics as Topic KW - Materials Testing KW - Photochemistry -- methods KW - Reactive Oxygen Species -- chemical synthesis KW - Metal Nanoparticles -- chemistry KW - Sulfides -- chemistry KW - Sulfides -- radiation effects KW - Metal Nanoparticles -- radiation effects KW - Reactive Oxygen Species -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1702091476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+applied+materials+%26+interfaces&rft.atitle=Composition+Directed+Generation+of+Reactive+Oxygen+Species+in+Irradiated+Mixed+Metal+Sulfides+Correlated+with+Their+Photocatalytic+Activities.&rft.au=He%2C+Weiwei%3BJia%2C+Huimin%3BYang%2C+Dongfang%3BXiao%2C+Pin%3BFan%2C+Xiaoli%3BZheng%2C+Zhi%3BKim%2C+Hyun-Kyung%3BWamer%2C+Wayne+G%3BYin%2C+Jun-Jie&rft.aulast=He&rft.aufirst=Weiwei&rft.date=2015-08-05&rft.volume=7&rft.issue=30&rft.spage=16440&rft.isbn=&rft.btitle=&rft.title=ACS+applied+materials+%26+interfaces&rft.issn=1944-8252&rft_id=info:doi/10.1021%2Facsami.5b03626 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-29 N1 - Date created - 2015-08-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acsami.5b03626 ER - TY - JOUR T1 - Analysis of lasalocid residues in grease and fat using liquid chromatography-mass spectrometry AN - 1717500283; PQ0002012354 AB - A method for the determination of lasalocid, an antibiotic and coccidiostat, in grease and fat is described. The manufacture of lasalocid produces a grease-like residue as a waste byproduct. Recently this byproduct has been shown to have been illegally introduced into the animal feed chain. Therefore, a quantitative and confirmatory procedure to analyse for lasalocid in this matrix is needed. A portion of grease/oil sample was extracted into hexane-washed acetonitrile, and a portion of the extract was then applied to a carboxylic acid solid-phase extraction (SPE) column for concentration and clean-up. The SPE column was washed with additional hexane-washed acetonitrile and ethyl acetate/methanol, after which lasalocid was eluted with 10% ammoniated methanol. The eluate was evaporated to dryness, redissolved in (1:1) acetonitrile-water and filtered through a PTFE syringe filter. Confirmation and quantitation of lasalocid in the final extract employed a triple quadrupole LC-MS/MS. The method was applied to grease and oil samples containing from 0.02 to 34 000 mg kg super(-1) of lasalocid. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Clark, Susan B AU - Storey, Joseph M AU - Carr, Justin R AU - Madson, Mark AD - Denver Laboratory, US Food and Drug Administration (USFDA), Denver, CO, USA PY - 2015 SP - 1243 EP - 1248 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 8 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Risk assessment KW - Residues KW - Byproducts KW - Methanol KW - Antibiotics KW - Spectrometry KW - Oil KW - Filters KW - Food additives KW - Carboxylic acids KW - Syringes KW - Animal feeds KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717500283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Analysis+of+lasalocid+residues+in+grease+and+fat+using+liquid+chromatography-mass+spectrometry&rft.au=Clark%2C+Susan+B%3BStorey%2C+Joseph+M%3BCarr%2C+Justin+R%3BMadson%2C+Mark&rft.aulast=Clark&rft.aufirst=Susan&rft.date=2015-08-03&rft.volume=32&rft.issue=8&rft.spage=1243&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1052572 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Filters; Risk assessment; Oil; Food additives; Residues; Methanol; Byproducts; Carboxylic acids; Animal feeds; Syringes; Antibiotics; Spectrometry DO - http://dx.doi.org/10.1080/19440049.2015.1052572 ER - TY - JOUR T1 - FDA Approval Summary: Ramucirumab for Gastric Cancer AN - 1808643082; PQ0003449714 AB - The FDA approved ramucirumab (CYRAMZA; Eli Lilly and Company) for previously treated patients with advanced or metastatic gastric or gastroesophageal junction adenocarcinoma initially as monotherapy (April 21, 2014) and subsequently as combination therapy with paclitaxel (November 5, 2014). In the monotherapy trial, 355 patients in the indicated population were randomly allocated (2:1) to receive ramucirumab or placebo, 8 mg/kg intravenously every 2 weeks. In the combination trial, 665 patients were randomly allocated (1:1) to receive ramucirumab or placebo, 8 mg/kg intravenously every 2 weeks, in combination with paclitaxel, 80 mg/m2 on days 1, 8, and 15 of 28-day cycles. Overall survival (OS) was increased in patients who received ramucirumab in both the monotherapy [HR, 0.78; 95% confidence interval (CI), 0.60-0.998; log rank P = 0.047] and combination trials (HR, 0.81; 95% CI, 0.68-0.96; P = 0.017). The most common adverse reactions were hypertension and diarrhea in the monotherapy trial and fatigue, neutropenia, diarrhea, and epistaxis in the combination trial. Because of concerns about the robustness of the monotherapy trial results, FDA approved the original application after receiving the results of the combination trial confirming the OS effect. Based on exploratory exposure-response analyses, there is residual uncertainty regarding the optimal dose of ramucirumab. Clin Cancer Res; 21(15); 3372-6. copyright 2015 AACR. JF - Clinical Cancer Research AU - Casak, Sandra J AU - Fashoyin-Aje, Ibilola AU - Lemery, Steven J AU - Zhang, Lillian AU - Jin, Runyan AU - Li, Hongshan AU - Zhao, Liang AU - Zhao, Hong AU - Zhang, Hui AU - Chen, Huanyu AU - He, Kun AU - Dougherty, Michele AU - Novak, Rachel AU - Kennett, Sarah AU - Khasar, Sachia AU - Helms, Whitney AU - Keegan, Patricia AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, Maryland, Sandra.Casak@fda.hhs.gov Y1 - 2015/08/01/ PY - 2015 DA - 2015 Aug 01 SP - 3372 EP - 3376 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 21 IS - 15 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Diarrhea KW - Fatigue KW - Survival KW - Clinical trials KW - Metastases KW - Neutropenia KW - Paclitaxel KW - Dose-response effects KW - Adenocarcinoma KW - Gastric cancer KW - Side effects KW - Hypertension KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808643082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=FDA+Approval+Summary%3A+Ramucirumab+for+Gastric+Cancer&rft.au=Casak%2C+Sandra+J%3BFashoyin-Aje%2C+Ibilola%3BLemery%2C+Steven+J%3BZhang%2C+Lillian%3BJin%2C+Runyan%3BLi%2C+Hongshan%3BZhao%2C+Liang%3BZhao%2C+Hong%3BZhang%2C+Hui%3BChen%2C+Huanyu%3BHe%2C+Kun%3BDougherty%2C+Michele%3BNovak%2C+Rachel%3BKennett%2C+Sarah%3BKhasar%2C+Sachia%3BHelms%2C+Whitney%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Casak&rft.aufirst=Sandra&rft.date=2015-08-01&rft.volume=21&rft.issue=15&rft.spage=3372&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-0600 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Metastases; Neutropenia; Fatigue; Diarrhea; Paclitaxel; Dose-response effects; Survival; Gastric cancer; Adenocarcinoma; Clinical trials; Side effects; Hypertension DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-0600 ER - TY - JOUR T1 - Services for children with autism spectrum disorder in three, large urban school districts: Perspectives of parents and educators AN - 1790893360 AB - This study used qualitative methods to evaluate the perceptions of parents, educators, and school administrators in three large, urban school districts (Los Angeles, Philadelphia, and Rochester) regarding services for children with autism spectrum disorder within the context of limited district resources. Facilitators followed a standard discussion guide that contained open-ended questions regarding participants' views on strengths and limitations of existing services and contextual factors that would facilitate or inhibit the process of introducing new interventions. Three primary themes were identified: (1) tension between participant groups (teachers and paraprofessionals, staff and administration, teachers and parents, special education and general education teachers), (2) necessity of autism spectrum disorder-specific and behavioral training for school personnel, and (3) desire for a school culture of accepting difference. These themes highlight the importance of developing trainings that are feasible to deliver on a large scale, that focus on practical interventions, and that enhance communication and relationships of school personnel with one another and with families. JF - Autism AU - Iadarola, Suzannah AU - Hetherington, Susan AU - Clinton, Christopher AU - Dean, Michelle AU - Reisinger, Erica AU - Huynh, Linh AU - Locke, Jill AU - Conn, Kelly AU - Heinert, Sara AU - Kataoka, Sheryl AU - Harwood, Robin AU - Smith, Tristram AU - Mandell, David S AU - Kasari, Connie AD - University of Rochester Medical Center, New York, USA ; University of California, Los Angeles, USA ; University of Pennsylvania, Pennsylvania, USA ; Health Resources & Services Administration, Maternal and Child Health Bureau, Maryland, USA Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 694 EP - 703 CY - London PB - SAGE PUBLICATIONS, INC. VL - 19 IS - 6 SN - 1362-3613 KW - Psychology KW - autism KW - community-based participatory research KW - qualitative research KW - school-based intervention KW - urban environments KW - Attitudes KW - Autistic children KW - Autistic spectrum disorders KW - Behavioural training KW - Contextual factors KW - Desire KW - Facilitators KW - General education KW - Interventions KW - Necessity KW - Paraprofessionals KW - Parenthood education KW - Parents KW - Personnel KW - Qualitative methods KW - Special education KW - Teachers KW - Los Angeles California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790893360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autism&rft.atitle=Services+for+children+with+autism+spectrum+disorder+in+three%2C+large+urban+school+districts%3A+Perspectives+of+parents+and+educators&rft.au=Iadarola%2C+Suzannah%3BHetherington%2C+Susan%3BClinton%2C+Christopher%3BDean%2C+Michelle%3BReisinger%2C+Erica%3BHuynh%2C+Linh%3BLocke%2C+Jill%3BConn%2C+Kelly%3BHeinert%2C+Sara%3BKataoka%2C+Sheryl%3BHarwood%2C+Robin%3BSmith%2C+Tristram%3BMandell%2C+David+S%3BKasari%2C+Connie&rft.aulast=Iadarola&rft.aufirst=Suzannah&rft.date=2015-08-01&rft.volume=19&rft.issue=6&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Autism&rft.issn=13623613&rft_id=info:doi/10.1177%2F1362361314548078 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2014 N1 - Last updated - 2017-02-08 N1 - SubjectsTermNotLitGenreText - Los Angeles California DO - http://dx.doi.org/10.1177/1362361314548078 ER - TY - JOUR T1 - Further Trends in Work-Related Musculoskeletal Disorders: A Comparison of Risk Factors for Symptoms Using Quality of Work Life Data From the 2002, 2006, and 2010 General Social Survey AN - 1722164459; PQ0002041235 AB - Objective: To report trends for the risk of musculoskeletal disorders. Methods: Three Quality of Work Life surveys examine the risk factors for musculoskeletal disorders. Results: Findings similar for several risk factors, but differences across the reporting years may reflect economic conditions. Respondent numbers in 2010 were reduced, some risk factors had pattern changes, and there were sex and age differences. Trend analysis showed most significant changes were for the "work fast" risk factor. New 2010 "physical effort" item showed sex differences, and items reflective of total worker health showed strong associations with "back pain" and "pain in arms." Conclusions: Intervention strategies should focus on physical exposures and psychosocial risk factors (work stress, safety climate, job satisfaction, supervisor support, work fast, work freedom, work time) that have been consistently related to reports of musculoskeletal disorders. Economic conditions will influence some psychosocial risk factors. JF - Journal of Occupational and Environmental Medicine AU - Dick, Robert B AU - Lowe, Brian D AU - Lu, Ming-Lun AU - Krieg, Edward F AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Safety and Occupational Health, Division of Applied Research and Technology, Organizational Science and Human Factors Branch, Cincinnati, Ohio, RBD1@cdc.gov PY - 2015 SP - 910 EP - 928 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 8 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Climate KW - Safety KW - Intervention KW - Stress KW - Pain KW - Back pain KW - Health risks KW - Musculoskeletal system KW - Risk factors KW - Economic conditions KW - Occupational health KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722164459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Further+Trends+in+Work-Related+Musculoskeletal+Disorders%3A+A+Comparison+of+Risk+Factors+for+Symptoms+Using+Quality+of+Work+Life+Data+From+the+2002%2C+2006%2C+and+2010+General+Social+Survey&rft.au=Dick%2C+Robert+B%3BLowe%2C+Brian+D%3BLu%2C+Ming-Lun%3BKrieg%2C+Edward+F&rft.aulast=Dick&rft.aufirst=Robert&rft.date=2015-08-01&rft.volume=57&rft.issue=8&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000501 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Health risks; Age; Musculoskeletal system; Risk factors; Safety; Climate; Stress; Intervention; Pain; Economic conditions; Back pain; Occupational health DO - http://dx.doi.org/10.1097/JOM.0000000000000501 ER - TY - JOUR T1 - Developing Surveillance Methodology for Agricultural and Logging Injury in New Hampshire Using Electronic Administrative Data Sets AN - 1722164426; PQ0002041229 AB - Objective: Agriculture and logging rank among industries with the highest rates of occupational fatality and injury. Establishing a nonfatal injury surveillance system is a top priority in the National Occupational Research Agenda. Sources of data such as patient care reports (PCRs) and hospitalization data have recently transitioned to electronic databases. Methods: Using narrative and location codes from PCRs, along with International Classification of Diseases, 9th Revision, external cause of injury codes (E-codes) in hospital data, researchers are designing a surveillance system to track farm and logging injury. Results: A total of 357 true agricultural or logging cases were identified. Conclusions: These data indicate that it is possible to identify agricultural and logging injury events in PCR and hospital data. Multiple data sources increase catchment; nevertheless, limitations in methods of identification of agricultural and logging injury contribute to the likely undercount of injury events. JF - Journal of Occupational and Environmental Medicine AU - Scott, Erika E AU - Hirabayashi, Liane AU - Krupa, Nicole L AU - Sorensen, Julie A AU - Jenkins, Paul L AD - Northeast Center for Occupational Health in Agriculture, Forestry and Fishing, NIOSH AgFF Center, Cooperstown, NY, erika.scott@bassett.org Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 866 EP - 872 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 8 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722164426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Developing+Surveillance+Methodology+for+Agricultural+and+Logging+Injury+in+New+Hampshire+Using+Electronic+Administrative+Data+Sets&rft.au=Scott%2C+Erika+E%3BHirabayashi%2C+Liane%3BKrupa%2C+Nicole+L%3BSorensen%2C+Julie+A%3BJenkins%2C+Paul+L&rft.aulast=Scott&rft.aufirst=Erika&rft.date=2015-08-01&rft.volume=57&rft.issue=8&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000482 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-10-15 DO - http://dx.doi.org/10.1097/JOM.0000000000000482 ER - TY - RPRT T1 - Table of contents AN - 1719234706 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1719234706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-08-01&rft.volume=&rft.issue=582&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2015 N1 - Last updated - 2015-10-06 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF VINYLIDENE CHLORIDE (CAS NO. 75-35-4) IN F344/N RATS AND B6C3F1/N MICE (INHALATION STUDIES) AN - 1719234607 AB - Vinylidene chloride is used to produce a variety of polymers, including fdms for food containers and coatings for products ranging from carpets and tapes to railroad containers. We exposed groups of 50 male and 50 female rats to atmospheres containing vapors of vinylidene chloride at concentrations of 25, 50, or 100 parts per million (ppm) for six hours per day, five days per week for two years; groups of mice were similarly exposed to atmospheres containing 6.25, 12.5, or 25 ppm of vinylidene chloride. Groups of 50 male and 50 female rats and mice exposed to clean air in the same type of inhalation chambers served as the control groups. Tissues from more than 40 sites were examined for every animal. All groups of male and female rats and mice exposed to vinylidene chloride had extensive non-cancerous lesions of the epithelium of the nose, including inflammation, metaplasia, hyperplasia, and atrophy. Male rats had markedly increased incidences of malignant mesotheliomas and some rare adenomas of the respiratory epithelium of the nose. Female rats had increased incidences of thyroid gland cancers and mononuclear cell leukemia. Male mice had marked increases of uncommon benign and malignant tumors of the kidney and female mice had increased incidences of hemangioma or hemangiosarcoma in all organs and a variety of liver tumors. We conclude that exposure to vinylidene chloride by inhalation caused malignant mesothelioma and cancers in the nose in male rats, thyroid gland cancers and mononuclear cell leukemia in female rats, kidney cancers in male mice, and hemangioma or hemangiosarcoma in all organs and liver tumors in female mice. A spectrum of nonneoplastic lesions in the nose of male and female rats and mice were caused by vinylidene chloride exposure. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 0_1,0_2,6 EP - 37,39-83C,85-91,93-115,117-163,165-175,177-189,191-193,195-229 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Toxicology KW - Rodents KW - Polymers KW - Cancer KW - Human exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1719234607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+VINYLIDENE+CHLORIDE+%28CAS+NO.+75-35-4%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-08-01&rft.volume=&rft.issue=582&rft.spage=0_1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2015 N1 - Document feature - Tables; Diagrams; Graphs; References N1 - Last updated - 2015-10-06 ER - TY - JOUR T1 - Retention of virulence following adaptation to colistin in Acinetobacter baumannii reflects the mechanism of resistance AN - 1712562905; PQ0001944553 AB - Objectives Colistin resistance in Acinetobacter baumannii has been associated with loss of virulence and a negative impact on isolate selection. In this study, exposure of clinical isolates to suboptimal concentrations of colistin was used to explore the capacity to develop resistance by diverse mechanisms, and whether acquired resistance always reduces fitness and virulence. Methods Twelve colistin-susceptible clinical A. baumannii isolates were exposed to a sub-MIC concentration of colistin over 6 weeks with weekly increases in concentration. Stable resistance was then phenotypically investigated with respect to antibiotic/biocide resistance, virulence in Galleria mellonella and growth rate. Putative mechanisms of resistance were identified by targeted sequencing of known resistance loci. Results Eight A. baumannii isolates acquired resistance to colistin within 1 week with MICs ranging from 2 to >512 mg/L. By 6 weeks 11 isolates were resistant to colistin; this was linked to the development of mutations in pmr or lpx genes. Strains that developed mutations in lpxACD showed a loss of virulence and increased susceptibility to several antibiotics/disinfectants tested. Two of the colistin-resistant strains with mutations in pmrB retained similar virulence levels to their respective parental strains in G. mellonella. Conclusions Acquisition of colistin resistance does not always lead to a loss of virulence, especially when this is linked to mutations in pmrB. This underlines the importance of understanding the mechanism of colistin resistance as well as the phenotype. JF - Journal of Antimicrobial Chemotherapy AU - Wand, Matthew E AU - Bock, Lucy J AU - Bonney, Laura C AU - Sutton, J Mark AD - Corresponding author. Tel: +44-(0)1980-612316; Fax: +44-(0)1980-612622; , matthew.wand@phe.gov.uk Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2209 EP - 2216 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 70 IS - 8 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Acinetobacter baumannii KW - colistin adaptation KW - Galleria mellonella KW - antibiotic resistance KW - Clinical isolates KW - Fitness KW - Growth rate KW - Adaptations KW - Antibiotics KW - Minimum inhibitory concentration KW - Colistin KW - Virulence KW - Disinfectants KW - Biocides KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712562905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Retention+of+virulence+following+adaptation+to+colistin+in+Acinetobacter+baumannii+reflects+the+mechanism+of+resistance&rft.au=Wand%2C+Matthew+E%3BBock%2C+Lucy+J%3BBonney%2C+Laura+C%3BSutton%2C+J+Mark&rft.aulast=Wand&rft.aufirst=Matthew&rft.date=2015-08-01&rft.volume=70&rft.issue=8&rft.spage=2209&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkv097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Growth rate; Fitness; Clinical isolates; Virulence; Colistin; Disinfectants; Adaptations; Antibiotics; Biocides; Minimum inhibitory concentration; Mutation; Acinetobacter baumannii; Galleria mellonella DO - http://dx.doi.org/10.1093/jac/dkv097 ER - TY - JOUR T1 - Correction of overstatement and omission in direct-to-consumer prescription drug advertising AN - 1710254655; 4699741 AB - Little experimental evidence exists regarding corrective television advertising as a remedy for misleading direct-to‐ ;consumer prescription drug ads. We examined how exposure to an ad for a fictitious prescription drug that appeared to offer benefits and risks superior to normative standards for asthma medication (i.e., a simulated violative ad) and a corresponding corrective ad shaped viewer perceptions, understanding, and intended behavior. Through an experiment with 1,057 participants, we found that a corrective ad counteracted viewer belief of an overstatement of efficacy claim, but was less successful in counteracting omission of risk. Corrective ad exposure also affected general viewer perceptions of, and intended behaviors toward, the drug. Reprinted by permission of Blackwell Publishers JF - Journal of communication AU - O' Donoghue, Amie C AU - Rupert, Douglas J AU - Lee, Philip K AU - Amoozegar, Jacqueline B AU - Southwell, Brian G AU - Aikin, Kathryn J AU - Betts, Kevin R AD - US Food and Drug Administration ; RTI International Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 596 EP - 618 VL - 65 IS - 4 SN - 0021-9916, 0021-9916 KW - Sociology KW - Perception KW - Television KW - Consumers KW - Correlation KW - Advertising KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1710254655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+communication&rft.atitle=Correction+of+overstatement+and+omission+in+direct-to-consumer+prescription+drug+advertising&rft.au=O%27+Donoghue%2C+Amie+C%3BRupert%2C+Douglas+J%3BLee%2C+Philip+K%3BAmoozegar%2C+Jacqueline+B%3BSouthwell%2C+Brian+G%3BAikin%2C+Kathryn+J%3BBetts%2C+Kevin+R&rft.aulast=O%27+Donoghue&rft.aufirst=Amie&rft.date=2015-08-01&rft.volume=65&rft.issue=4&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Journal+of+communication&rft.issn=00219916&rft_id=info:doi/10.1111%2Fjcom.12167 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-09-09 N1 - Last updated - 2015-09-09 N1 - SubjectsTermNotLitGenreText - 12648 7862 2572; 608 7738 11245 11239; 3755; 2803 3874 556; 9382; 2904 12224 971 DO - http://dx.doi.org/10.1111/jcom.12167 ER - TY - JOUR T1 - Quantile benchmark dose estimation for continuous endpoints AN - 1709765532; PQ0001722505 AB - Quantitative risk assessment (QRA) characterizes the risk of an adverse health outcome for an organism exposed to a chemical, environmental, physical, or other hazard. Historically, QRAs define risk based upon the increased probability of adverse response because of exposure when compared with the background probability of response in unexposed individuals. For a specified risk level, the exposure-response relationship is inverted to find an exposure (or dose) for minimizing risk; these exposures are often called the benchmark dose (BMD). For continuous endpoints, BMD analyses have employed strong assumptions on the form of the response distribution which may not be met for most toxicology data sets. We propose a reformulation of the BMD for use in QRA for continuous response that is based upon milder assumptions using quantile regression and monotone smoothing splines. This method takes into account the uncertainty in the response distribution as well as uncertainty in the exposure-response relationship. We apply this method to a data example and show through a simulation study that the approach is often superior to current practice. JF - Environmetrics AU - Wheeler, Matthew W AU - Shao, Kan AU - Bailer, AJohn AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, U.S.A. Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 363 EP - 372 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 5 SN - 1180-4009, 1180-4009 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Uncertainty KW - Risk KW - Data sets KW - Quantiles KW - Exposure KW - Regression analysis KW - Regression KW - Benchmarking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709765532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmetrics&rft.atitle=Quantile+benchmark+dose+estimation+for+continuous+endpoints&rft.au=Wheeler%2C+Matthew+W%3BShao%2C+Kan%3BBailer%2C+AJohn&rft.aulast=Wheeler&rft.aufirst=Matthew&rft.date=2015-08-01&rft.volume=26&rft.issue=5&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Environmetrics&rft.issn=11804009&rft_id=info:doi/10.1002%2Fenv.2342 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-12-07 DO - http://dx.doi.org/10.1002/env.2342 ER - TY - JOUR T1 - A high-resolution computational model of the deforming human heart AN - 1709190514; PQ0001897716 AB - Modeling of the heart ventricles is one of the most challenging tasks in soft tissue mechanics because cardiac tissue is a strongly anisotropic incompressible material with an active component of stress. In most current approaches with active force, the number of degrees of freedom (DOF) is limited by the direct method of solution of linear systems of equations. We develop a new approach for high-resolution heart models with large numbers of DOF by: (1) developing a hex-dominant finite element mixed formulation and (2) developing a Krylov subspace iterative method that is able to solve the system of linearized equations for saddle-point problems with active stress. In our approach, passive cardiac tissue is modeled as a hyperelastic, incompressible material with orthotropic properties, and mixed pressure-displacement finite elements are used to enforce incompressibility. Active stress is generated by a model with force dependence on length and velocity of muscle shortening. The ventricles are coupled to a lumped circulatory model. For efficient solution of linear systems, we use Flexible GMRES with a nonlinear preconditioner based on block matrix decomposition involving the Schur complement. Three methods for approximating the inverse of the Schur complement are evaluated: inverse of the pressure mass matrix; least squares commutators; and sparse approximate inverse. The sub-matrix corresponding to the displacement variables is preconditioned by a V-cycle of hybrid geometric-algebraic multigrid followed by correction with several iterations of GMRES preconditioned by sparse approximate inverse. The overall solver is demonstrated on a high-resolution two ventricle mesh based on a human anatomy with roughly 130 K elements and 1.7 M displacement DOF. Effectiveness of the numerical method for active contraction is shown. To the best of our knowledge, this solver is the first to efficiently model ventricular contraction using an iterative linear solver for the mesh size demonstrated and therefore opens the possibility for future very high-resolution models. In addition, several relatively simple benchmark problems are designed for a verification exercise to show that the solver is functioning properly and correctly solves the underlying mathematical model. Here, the output of the newly designed solver is compared to that of the mechanics component of Chaste ('Cancer, Heart and Soft Tissue Environment'). These benchmark tests may be used by other researchers to verify their newly developed methods and codes. JF - Biomechanics and Modeling in Mechanobiology AU - Gurev, Viatcheslav AU - Pathmanathan, Pras AU - Fattebert, Jean-Luc AU - Wen, Hui-Fang AU - Magerlein, John AU - Gray, Richard A AU - Richards, David F AU - Rice, JJeremy AD - Thomas J. Watson Research Center, IBM Research, 1101 Kitchawan Rd, Yorktown Heights, NY, 10598, USA, pras.pathmanathan@fda.hhs.gov Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 829 EP - 849 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 14 IS - 4 SN - 1617-7959, 1617-7959 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Calcium & Calcified Tissue Abstracts KW - Heart KW - Muscle contraction KW - Mathematical models KW - Anisotropy KW - Stress KW - Cancer KW - Physical training KW - Ventricle KW - Hybrids KW - Pressure KW - Soft tissues KW - Mechanical properties KW - N3 11002:Computational & theoretical neuroscience KW - T 2010:Muscle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709190514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomechanics+and+Modeling+in+Mechanobiology&rft.atitle=A+high-resolution+computational+model+of+the+deforming+human+heart&rft.au=Gurev%2C+Viatcheslav%3BPathmanathan%2C+Pras%3BFattebert%2C+Jean-Luc%3BWen%2C+Hui-Fang%3BMagerlein%2C+John%3BGray%2C+Richard+A%3BRichards%2C+David+F%3BRice%2C+JJeremy&rft.aulast=Gurev&rft.aufirst=Viatcheslav&rft.date=2015-08-01&rft.volume=14&rft.issue=4&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=Biomechanics+and+Modeling+in+Mechanobiology&rft.issn=16177959&rft_id=info:doi/10.1007%2Fs10237-014-0639-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 60 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Heart; Muscle contraction; Ventricle; Anisotropy; Mathematical models; Hybrids; Stress; Pressure; Soft tissues; Cancer; Physical training; Mechanical properties DO - http://dx.doi.org/10.1007/s10237-014-0639-8 ER - TY - JOUR T1 - Reaerosolization of Spores from Flooring Surfaces To Assess the Risk of Dissemination and Transmission of Infections AN - 1709186555; PQ0001900749 AB - The aim of this study was to quantify reaerosolization of microorganisms caused by walking on contaminated flooring to assess the risk to individuals accessing areas contaminated with pathogenic organisms, for example, spores of Bacillus anthracis. Industrial carpet and polyvinyl chloride (PVC) floor coverings were contaminated with aerosolized spores of Bacillus atrophaeus by using an artist airbrush to produce deposition of similar to 103 to 104 CFU . cm-2. Microbiological air samplers were used to quantify the particle size distribution of the aerosol generated when a person walked over the floorings in an environmental chamber. Results were expressed as reaerosolization factors (percent per square centimeter per liter), to represent the ratio of air concentration to surface concentration generated. Walking on carpet generated a statistically significantly higher reaerosolization factor value than did walking on PVC (t = 20.42; P < 0.001). Heavier walking produced a statistically significantly higher reaerosolization factor value than did lighter walking (t = 12.421; P < 0.001). Height also had a statistically significant effect on the reaerosolization factor, with higher rates of recovery of B. atrophaeus at lower levels, demonstrating a height-dependent gradient of particle reaerosolization. Particles in the respirable size range were recovered in all sampling scenarios (mass mean diameters ranged from 2.6 to 4.1 mu m). The results of this study can be used to produce a risk assessment of the potential aerosol exposure of a person accessing areas with contaminated flooring in order to inform the choice of appropriate respiratory protective equipment and may aid in the selection of the most suitable flooring types for use in health care environments, to reduce aerosol transmission in the event of contamination. JF - Applied and Environmental Microbiology AU - Paton, Susan AU - Thompson, Katy-Anne AU - Parks, Simon R AU - Bennett, Allan M PY - 2015 SP - 4914 EP - 4919 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 15 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Particle size KW - Risk assessment KW - Aerosols KW - Contamination KW - Statistical analysis KW - polyvinyl chloride KW - Walking KW - Bacillus anthracis KW - Infection KW - Samplers KW - Disease transmission KW - Carpets KW - Colony-forming cells KW - Microorganisms KW - Sampling KW - Spores KW - Environmental chambers KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709186555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Reaerosolization+of+Spores+from+Flooring+Surfaces+To+Assess+the+Risk+of+Dissemination+and+Transmission+of+Infections&rft.au=Paton%2C+Susan%3BThompson%2C+Katy-Anne%3BParks%2C+Simon+R%3BBennett%2C+Allan+M&rft.aulast=Paton&rft.aufirst=Susan&rft.date=2015-08-01&rft.volume=81&rft.issue=15&rft.spage=4914&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00412-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 20 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Risk assessment; Particle size; Aerosols; Contamination; polyvinyl chloride; Statistical analysis; Walking; Infection; Samplers; Disease transmission; Carpets; Colony-forming cells; Microorganisms; Sampling; Spores; Environmental chambers; Bacillus anthracis DO - http://dx.doi.org/10.1128/AEM.00412-15 ER - TY - JOUR T1 - High-Resolution Analysis by Whole-Genome Sequencing of an International Lineage (Sequence Type 111) of Pseudomonas aeruginosa Associated with Metallo-Carbapenemases in the United Kingdom AN - 1709184232; PQ0001900900 AB - Whole-genome sequencing (WGS) was carried out on 87 isolates of sequence type 111 (ST-111) of Pseudomonas aeruginosa collected between 2005 and 2014 from 65 patients and 12 environmental isolates from 24 hospital laboratories across the United Kingdom on an Illumina HiSeq instrument. Most isolates (73) carried VIM-2, but others carried IMP-1 or IMP-13 (5) or NDM-1 (1); one isolate had VIM-2 and IMP-18, and 7 carried no metallo-beta-lactamase (MBL) gene. Single nucleotide polymorphism analysis divided the isolates into distinct clusters; the NDM-1 isolate was an outlier, and the IMP isolates and 6/7 MBL-negative isolates clustered separately from the main set of 73 VIM-2 isolates. Within the VIM-2 set, there were at least 3 distinct clusters, including a tightly clustered set of isolates from 3 hospital laboratories consistent with an outbreak from a single introduction that was quickly brought under control and a much broader set dominated by isolates from a long-running outbreak in a London hospital likely seeded from an environmental source, requiring different control measures; isolates from 7 other hospital laboratories in London and southeast England were also included. Bayesian evolutionary analysis indicated that all the isolates shared a common ancestor dating back similar to 50 years (1960s), with the main VIM-2 set separating approximately 20 to 30 years ago. Accessory gene profiling revealed blocks of genes associated with particular clusters, with some having high similarity ( greater than or equal to 95%) to bacteriophage genes. WGS of widely found international lineages such as ST-111 provides the necessary resolution to inform epidemiological investigations and intervention policies. JF - Journal of Clinical Microbiology AU - Turton, Jane F AU - Wright, Laura AU - Underwood, Anthony AU - Witney, Adam A AU - Chan, Yuen-Ting AU - Al-Shahib, Ali AU - Arnold, Catherine AU - Doumith, Michel AU - Patel, Bharat AU - Planche, Timothy D AD - Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health England, Colindale, London, United Kingdom, jane.turton@phe.gov.uk. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 2622 EP - 2631 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 8 SN - 0095-1137, 0095-1137 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Phages KW - Inosine monophosphate KW - Mbl protein KW - Single-nucleotide polymorphism KW - Bayesian analysis KW - Dating KW - Pseudomonas aeruginosa KW - Evolution KW - Hospitals KW - N 14845:Miscellaneous KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709184232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=High-Resolution+Analysis+by+Whole-Genome+Sequencing+of+an+International+Lineage+%28Sequence+Type+111%29+of+Pseudomonas+aeruginosa+Associated+with+Metallo-Carbapenemases+in+the+United+Kingdom&rft.au=Turton%2C+Jane+F%3BWright%2C+Laura%3BUnderwood%2C+Anthony%3BWitney%2C+Adam+A%3BChan%2C+Yuen-Ting%3BAl-Shahib%2C+Ali%3BArnold%2C+Catherine%3BDoumith%2C+Michel%3BPatel%2C+Bharat%3BPlanche%2C+Timothy+D&rft.aulast=Turton&rft.aufirst=Jane&rft.date=2015-08-01&rft.volume=53&rft.issue=8&rft.spage=2622&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00505-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 48 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Phages; Mbl protein; Inosine monophosphate; Bayesian analysis; Single-nucleotide polymorphism; Dating; Evolution; Hospitals; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1128/JCM.00505-15 ER - TY - JOUR T1 - Whole-Genome Sequencing Data for Serotyping Escherichia coli-It's Time for a Change! AN - 1709165054; PQ0001900954 AB - The accessibility of whole-genome sequencing (WGS) presents the opportunity for national reference laboratories to provide a state-of-the-art public health surveillance service. The replacement of traditional serology-based typing of Escherichia coli by WGS is supported by user-friendly, freely available data analysis Web tools. An article in this issue of the Journal of Clinical Microbiology (K. G. Joensen, A. M. M. Tetzschner, A. Iguchi, F. M. Aarestrup, and F. Scheutz, J Clin Microbiol, 53:2410-2426, 2015, http://dx.doi.org/10.1128/JCM.00008-15) describes SerotypeFinder, an essential guide to serotyping E. coli in the 21st century. JF - Journal of Clinical Microbiology AU - Jenkins, Claire Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 2402 EP - 2403 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 8 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Typing KW - Escherichia coli KW - Serotyping KW - Public health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709165054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Whole-Genome+Sequencing+Data+for+Serotyping+Escherichia+coli-It%27s+Time+for+a+Change%21&rft.au=Jenkins%2C+Claire&rft.aulast=Jenkins&rft.aufirst=Claire&rft.date=2015-08-01&rft.volume=53&rft.issue=8&rft.spage=2402&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01448-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 11 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Typing; Data processing; Serotyping; Public health; Escherichia coli DO - http://dx.doi.org/10.1128/JCM.01448-15 ER - TY - JOUR T1 - Communication in a Human biomonitoring study: Focus group work, public engagement and lessons learnt in 17 European countries. AN - 1706208191; 25499539 AB - A communication strategy was developed by The Consortium to Perform Human Biomonitoring on a European Scale (COPHES), as part of its objectives to develop a framework and protocols to enable the collection of comparable human biomonitoring data throughout Europe. The framework and protocols were tested in the pilot study DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale). The aims of the communication strategy were to raise awareness of human biomonitoring, encourage participation in the study and to communicate the study results and their public health significance. It identified the audiences and key messages, documented the procedure for dissemination of results and was updated as the project progressed. A communication plan listed the tools and materials such as press releases, flyers, recruitment letters and information leaflets required for each audience with a time frame for releasing them. Public insight research was used to evaluate the recruitment material, and the feedback was used to improve the documents. Dissemination of results was coordinated in a step by step approach by the participating countries within DEMOCOPHES, taking into account specific national messages according to the needs of each country. Participants received individual results, unless they refused to be informed, along with guidance on what the results meant. The aggregate results and policy recommendations were then communicated to the general public and stakeholders, followed by dissemination at European level. Several lessons were learnt that may assist other future human biomonitoring studies. Recruitment took longer than anticipated and so social scientists, to help with community engagement, should be part of the research team from the start. As a European study, involving multiple countries, additional considerations were needed for the numerous organisations, different languages, cultures, policies and priorities. Therefore, communication documents should be seen as templates with essential information clearly indicated and the option for each country to tailor the material to reflect these differences. Future studies should consider setting up multidisciplinary networks of medical professionals and communication experts, and holding training workshops to discuss the interpretation of results and risk communication. Publicity and wide dissemination of the results helped to raise awareness of human biomonitoring to the general public, policy makers and other key stakeholders. Effective and timely communication, at all stages of a study, is essential if the potential of human biomonitoring research to improve public health is to be realised. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. JF - Environmental research AU - Exley, Karen AU - Cano, Noemi AU - Aerts, Dominique AU - Biot, Pierre AU - Casteleyn, Ludwine AU - Kolossa-Gehring, Marike AU - Schwedler, Gerda AU - Castaño, Argelia AU - Angerer, Jürgen AU - Koch, Holger M AU - Esteban, Marta AU - Schoeters, Greet AU - Den Hond, Elly AU - Horvat, Milena AU - Bloemen, Louis AU - Knudsen, Lisbeth E AU - Joas, Reinhard AU - Joas, Anke AU - Dewolf, Marie-Christine AU - Van de Mieroop, Els AU - Katsonouri, Andromachi AU - Hadjipanayis, Adamos AU - Cerna, Milena AU - Krskova, Andrea AU - Becker, Kerstin AU - Fiddicke, Ulrike AU - Seiwert, Margarete AU - Mørck, Thit A AU - Rudnai, Peter AU - Kozepesy, Szilvia AU - Cullen, Elizabeth AU - Kellegher, Anne AU - Gutleb, Arno C AU - Fischer, Marc E AU - Ligocka, Danuta AU - Kamińska, Joanna AU - Namorado, Sónia AU - Reis, M Fátima AU - Lupsa, Ioana-Rodica AU - Gurzau, Anca E AU - Halzlova, Katarina AU - Jajcaj, Michal AU - Mazej, Darja AU - Tratnik, Janja Snoj AU - Huetos, Olga AU - López, Ana AU - Berglund, Marika AU - Larsson, Kristin AU - Sepai, Ovnair AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, South Oxfordshire OX10 8BW, United Kingdom. Electronic address: karen.exley@phe.gov.uk. ; Independent TV Director and Communications Consultant, Barcelona, Spain. ; Federal Public Service Health, Food Chain Safety and Environment, Brussels, Belgium. ; University of Leuven, Leuven, Belgium. ; Federal Environment Agency (UBA), Berlin, Germany. ; Environmental Toxicology, Centro Nacional de Sanidad Ambiental, Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain. ; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance-Institute of the Ruhr-Universitat Bochum (IPA), Bochum, Germany. ; Flemish Institute for Technological Research (VITO), Environmental Risk and Health Unit, Belgium; University of Antwerp, Belgium. ; Flemish Institute for Technological Research (VITO), Environmental Risk and Health Unit, Belgium. ; Jožef Stefan Institute, Ljubljana, Slovenia. ; Environmental Health Science International, Hulst, The Netherlands. ; University of Copenhagen, Copenhagen, Denmark. ; BiPRO GmbH, Munich, Germany. ; Hainaut Vigilance Sanitaire and Hygiene Publique in Hainaut, Mons, Belgium. ; Provincial Institute for Hygiene, Kronenburgstraat 45, 2000 Antwerp, Belgium. ; State General Laboratory (SGL), Ministry of Health, Republic of Cyprus. ; Larnaca General Hospital, Ministry of Health, Republic of Cyprus. ; National Institute of Public Health, Prague, Czech Republic. ; National Institute of Environmental Health, Budapest, Hungary. ; Health Service Executive, Dublin, Ireland. ; Centre de Recherche Public Gabriel Lippmann, Belvaux, Luxembourg. ; Laboratoire National de Santé, Dudelange, Luxembourg. ; Nofer Institute of Occupational Medicine, Łódź, Poland. ; Institute of Preventive Medicine, Lisbon Faculty of Medicine, Portugal. ; Environmental Health Center, Cluj, Romania. ; Public Health Authority of the Slovak Republic, Bratislava, Slovakia. ; Karolinska Institute, Stockholm, Sweden. ; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, South Oxfordshire OX10 8BW, United Kingdom. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 31 EP - 41 VL - 141 KW - Index Medicus KW - Biomonitoring KW - Communication KW - Participatory research KW - Public insight KW - Humans KW - Information Dissemination KW - Sampling Studies KW - Europe KW - Public Policy KW - Health Policy KW - Research Design KW - Focus Groups KW - International Cooperation KW - Program Development KW - Community Participation KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1706208191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Communication+in+a+Human+biomonitoring+study%3A+Focus+group+work%2C+public+engagement+and+lessons+learnt+in+17+European+countries.&rft.au=Exley%2C+Karen%3BCano%2C+Noemi%3BAerts%2C+Dominique%3BBiot%2C+Pierre%3BCasteleyn%2C+Ludwine%3BKolossa-Gehring%2C+Marike%3BSchwedler%2C+Gerda%3BCasta%C3%B1o%2C+Argelia%3BAngerer%2C+J%C3%BCrgen%3BKoch%2C+Holger+M%3BEsteban%2C+Marta%3BSchoeters%2C+Greet%3BDen+Hond%2C+Elly%3BHorvat%2C+Milena%3BBloemen%2C+Louis%3BKnudsen%2C+Lisbeth+E%3BJoas%2C+Reinhard%3BJoas%2C+Anke%3BDewolf%2C+Marie-Christine%3BVan+de+Mieroop%2C+Els%3BKatsonouri%2C+Andromachi%3BHadjipanayis%2C+Adamos%3BCerna%2C+Milena%3BKrskova%2C+Andrea%3BBecker%2C+Kerstin%3BFiddicke%2C+Ulrike%3BSeiwert%2C+Margarete%3BM%C3%B8rck%2C+Thit+A%3BRudnai%2C+Peter%3BKozepesy%2C+Szilvia%3BCullen%2C+Elizabeth%3BKellegher%2C+Anne%3BGutleb%2C+Arno+C%3BFischer%2C+Marc+E%3BLigocka%2C+Danuta%3BKami%C5%84ska%2C+Joanna%3BNamorado%2C+S%C3%B3nia%3BReis%2C+M+F%C3%A1tima%3BLupsa%2C+Ioana-Rodica%3BGurzau%2C+Anca+E%3BHalzlova%2C+Katarina%3BJajcaj%2C+Michal%3BMazej%2C+Darja%3BTratnik%2C+Janja+Snoj%3BHuetos%2C+Olga%3BL%C3%B3pez%2C+Ana%3BBerglund%2C+Marika%3BLarsson%2C+Kristin%3BSepai%2C+Ovnair&rft.aulast=Exley&rft.aufirst=Karen&rft.date=2015-08-01&rft.volume=141&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2014.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-05 N1 - Date created - 2015-08-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envres.2014.12.003 ER - TY - JOUR T1 - Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks AN - 1705068839; PQ0001840124 AB - Chronic inhalation of vanadium pentoxide (V sub(2)O sub(5)) increases the incidence of alveolar/bronchiolar tumors in male and female B sub(6)C sub(3)F sub(1) mice at 1, 2, or 4mg/m super(3). The genotoxicity of V sub(2)O sub(5) has been extensively investigated in the literature with mixed results. In general, tests for gene mutations have been negative. Both positive and negative results were reported for clastogenicity in vitro with some reports suggesting aneugenic potential. In vivo, V sub(2)O sub(5) was negative in the mouse micronucleus test (erythrocyte) and comet assay (lung). Previously, K-ras mutations have been detected in the lung tumors in mice exposed to V sub(2)O sub(5). Recently, a short-term inhalation study in B sub(6)C sub(3)F sub(1) mice reported slight induction of 8-oxodGuo DNA lesions in lungs. Because 8-oxodGuo DNA lesions can lead to gene mutations if not repaired or if misrepaired, we have used groups of transgenic Big Blue (BB) mice (B sub(6)C sub(3)F sub(1)) to test whether V sub(2)O sub(5) has mutagenic potential in vivo in the tumor target tissue under the conditions of the bioassay. Groups of six male BB mice were exposed to particulate aerosols containing 0, 0.1, or 1mg/m super(3) (tumorigenic concentration) V sub(2)O sub(5) for 4 or 8 weeks (6h/day, 5 days/week) and cII mutant frequencies (MFs) were evaluated in the right lungs. A significant increase in lung weight was noted in mice exposed to 1mg/m super(3) V sub(2)O sub(5) (P less than or equal to 0.05) compared to sham control, confirming exposure to an inflammatory level of the test material. The mean MFs (x10 super(-6)) of mice in the 4-week exposure groups were 30 (sham control), 39 (0.1mg/m super(3)), and 24 (1mg/m super(3)) while the corresponding values in the 8-week exposure groups were 29, 48, and 17, respectively. None of these cII MFs measured at any time point was significantly higher than the corresponding control MFs (P greater than or equal to 0.1). Overall, these results suggest that mutagenicity is not likely to be an initial key event in the lung tumorigenicity of V sub(2)O sub(5). JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Manjanatha, Mugimane G AU - Shelton, Sharon D AU - Haber, Lynne AU - Gollapudi, Bhaskar AU - MacGregor, Judith A AU - Rajendran, Narayanan AU - Moore, Martha M AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, USFDA, Jefferson, AR, United States Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 46 EP - 52 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 789 SN - 1383-5718, 1383-5718 KW - Genetics Abstracts; Toxicology Abstracts KW - Vanadium pentoxide mutagenicity in lungs by inhalation study KW - cII mutagenicity in Big Blue mice KW - Mutagenic mode of action for the carcinogenicity of vanadium pentoxide KW - Inhalation KW - Aerosols KW - Mutagenicity KW - Erythrocytes KW - Point mutation KW - Genotoxicity KW - Tumorigenicity KW - Mutant frequency KW - Tumors KW - Alveoli KW - Mutagenesis KW - Inflammation KW - K-Ras protein KW - Lung KW - Clastogenicity KW - DNA KW - Comet assay KW - vanadium pentoxide KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705068839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Evaluation+of+cII+mutations+in+lung+of+male+Big+Blue+mice+exposed+by+inhalation+to+vanadium+pentoxide+for+up+to+8+weeks&rft.au=Manjanatha%2C+Mugimane+G%3BShelton%2C+Sharon+D%3BHaber%2C+Lynne%3BGollapudi%2C+Bhaskar%3BMacGregor%2C+Judith+A%3BRajendran%2C+Narayanan%3BMoore%2C+Martha+M&rft.aulast=Manjanatha&rft.aufirst=Mugimane&rft.date=2015-08-01&rft.volume=789&rft.issue=&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2015.06.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Inhalation; Mutagenicity; Aerosols; Genotoxicity; Point mutation; Erythrocytes; Tumorigenicity; Mutant frequency; Tumors; Alveoli; Inflammation; Mutagenesis; K-Ras protein; Lung; Clastogenicity; DNA; Comet assay; vanadium pentoxide DO - http://dx.doi.org/10.1016/j.mrgentox.2015.06.014 ER - TY - JOUR T1 - Quantification of Kras mutant fraction in the lung DNA of mice exposed to aerosolized particulate vanadium pentoxide by inhalation AN - 1705066836; PQ0001840126 AB - This study investigated whether Kras mutation is an early event in the development of lung tumors induced by inhalation of particulate vanadium pentoxide (VP) aerosols. A National Toxicology Program tumor bioassay of inhaled particulate VP aerosols established that VP-induced alveolar/bronchiolar carcinomas of the B6C3F1 mouse lung carried Kras mutations at a higher frequency than observed in spontaneous mouse lung tumors. Therefore, this study sought to: (1) characterize any Kras mutational response with respect to VP exposure concentration, and (2) investigate the possibility that amplification of preexisting Kras mutation is an early event in VP-induced mouse lung tumorigenesis. Male Big Blue B6C3F1 mice (6 mice/group) were exposed to aerosolized particulate VP by inhalation, 6h/day, 5 days/week for 4 or 8 weeks, using VP exposure concentrations of 0, 0.1, and 1mg/m3. The levels of two different Kras codon 12 mutations [GGT arrow right GAT (G12D) and GGT arrow right GTT (G12V)] were measured in lung DNAs by Allele-specific Competitive Blocker PCR (ACB-PCR). For both exposure concentrations (0.1 and 1.0mg/m3) and both time points (4 and 8 weeks), the mutant fractions observed in VP-exposed mice were not significantly different from the concurrent controls. Given that 8 weeks of inhalation of a tumorigenic concentration of particulate aerosols of VP did not result in a significant change in levels of lung Kras mutation, the data do not support either a direct genotoxic effect of VP on Kras or early amplification of preexisting mutation as being involved in the genesis of VP-induced mouse lung tumors under the exposure conditions used. Rather, the data suggest that accumulation of Kras mutation occurs later with chronic VP exposure and is likely not an early event in VP-induced mouse lung carcinogenesis. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Banda, Malathi AU - McKim, Karen L AU - Haber, Lynne T AU - MacGregor, Judith A AU - Gollapudi, BBhaskar AU - Parsons, Barbara L AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, United States Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 53 EP - 60 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 789 SN - 1383-5718, 1383-5718 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Toxicology Abstracts KW - ACB-PCR allele-specific competitive blocker-polymerase chain reaction KW - MOA mode of action KW - MF mutant fraction KW - NTP national toxicology program KW - PCR polymerase chain reaction KW - VP vanadium pentoxide KW - WT wild-type KW - Mutation KW - Mode of action KW - Carcinogenesis KW - Vanadium pentoxide KW - Inhalation KW - Aerosols KW - Data processing KW - Genotoxicity KW - Tumorigenesis KW - Alveoli KW - Carcinoma KW - Mutagenesis KW - K-Ras protein KW - Lung KW - Codons KW - Polymerase chain reaction KW - vanadium pentoxide KW - G 07710:Chemical Mutagenesis & Radiation KW - N 14845:Miscellaneous KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705066836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Quantification+of+Kras+mutant+fraction+in+the+lung+DNA+of+mice+exposed+to+aerosolized+particulate+vanadium+pentoxide+by+inhalation&rft.au=Banda%2C+Malathi%3BMcKim%2C+Karen+L%3BHaber%2C+Lynne+T%3BMacGregor%2C+Judith+A%3BGollapudi%2C+BBhaskar%3BParsons%2C+Barbara+L&rft.aulast=Banda&rft.aufirst=Malathi&rft.date=2015-08-01&rft.volume=789&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2015.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Inhalation; Aerosols; Data processing; Tumorigenesis; Genotoxicity; Alveoli; Mutagenesis; Carcinoma; K-Ras protein; Lung; Carcinogenesis; Codons; Polymerase chain reaction; Mutation; vanadium pentoxide DO - http://dx.doi.org/10.1016/j.mrgentox.2015.07.003 ER - TY - JOUR T1 - Antipsychotic Cardiometabolic Side Effect Monitoring in a State Community Mental Health System AN - 1704939090 AB - Antipsychotic medications can cause serious cardiometabolic side effects. No recent research has broadly evaluated monitoring and strategies to improve monitoring in U.S. public mental health systems. To address this knowledge gap, we evaluated education with audit and feedback to leaders to improve cardiometabolic monitoring in a state mental health system. We used Chi square statistics and logistic regressions to explore changes in monitoring recorded in randomly sampled records over 2 years. In 2009, assessment of patients on antipsychotics was 29.6 % for cholesterol, 40.4 % for glucose, 29.1 % for triglycerides, 54.3 % for weight, 33.6 % for blood pressure, and 5.7 % for abdominal girth. In 2010, four of ten mental health centers improved their rate of adult laboratory monitoring. Overall monitoring in the state did not increase. Education for prescribers with audit and feedback to leaders can improve monitoring in some settings, but more intensive and/or prolonged interventions may be required. JF - Community Mental Health Journal AU - Nesnera, Alex AU - Kelly, Michael AU - Orsini, Karen AU - Xie, Haiyi AU - McHugo, Greg AU - Bartels, Stephen AU - Brunette, Mary F AD - Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA ; Bureau of Behavioral Health, Department of Health and Human Services, Hanover, NH, USA ; Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA, Bureau of Behavioral Health, Department of Health and Human Services, Hanover, NH, USA ; Cotes, Robert O; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 80 Jesse Hill Jr Dr SE, Atlanta, GA, 30303, USA Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 685 EP - 694 CY - New York PB - Springer Science & Business Media VL - 51 IS - 6 SN - 0010-3853 KW - Psychology KW - Blood Pressure KW - Health Care Services KW - Public Health KW - Health KW - Community Mental Health KW - Mental Health KW - Knowledge KW - Patients KW - Health care KW - Audits KW - Intensive care KW - Side effects KW - Antipsychotic drugs KW - Interventions KW - Feedback KW - Community mental health services KW - Blood pressure KW - Mental health services KW - Glucose KW - Cholesterol KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704939090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Antipsychotic+Cardiometabolic+Side+Effect+Monitoring+in+a+State+Community+Mental+Health+System&rft.au=Cotes%2C+Robert+O%3BNesnera%2C+Alex%3BKelly%2C+Michael%3BOrsini%2C+Karen%3BXie%2C+Haiyi%3BMcHugo%2C+Greg%3BBartels%2C+Stephen%3BBrunette%2C+Mary+F&rft.aulast=Cotes&rft.aufirst=Robert&rft.date=2015-08-01&rft.volume=51&rft.issue=6&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-015-9833-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Social Services Abstracts N1 - Date revised - 2015-08-18 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1007/s10597-015-9833-0 ER - TY - JOUR T1 - Sexualized behaviors partially mediate the link between maltreatment and delinquent behaviors AN - 1704341468; 4694849 AB - The link between child maltreatment and juvenile delinquency has been well established, yet the underlying mechanisms through which the relationship may be explained are not very well understood. Although sexualized behaviors have been most studied in the context of sexual abuse, increasing evidence suggests that a broader conceptualization is warranted. Therefore, the current study tested sexualized behaviors as a mediator in the relation between child maltreatment of any type and delinquent behaviors using structural equation modeling. This study used a multi-site prospective sample of 804 children who were at high-risk for experiencing maltreatment and part of the Longitudinal Studies of Child Abuse and Neglect consortium. This study found that reported maltreatment was related to delinquency, and sexualized behaviors partially mediated the relationship between child maltreatment and juvenile delinquency. Specifically, children with more maltreatment reports before age 8 had increased sexualized behaviors at age 8, which in turn predicted greater delinquent behaviors at age 12. These results suggest that in addition to maltreatment experiences, early sexualized behaviors (i.e., at age 8) may also be markers for subsequent delinquent behaviors (i.e., at age 12). Researchers and clinicians should work to further clarify the connections among child maltreatment, sexualized behaviors, and delinquency. Reprinted by permission of Springer JF - Journal of child and family studies AU - Merrick, Melissa T AU - Litrownik, Alan J AU - Margolis, Benyamin AU - Wiley, Tisha R.A. AU - Everson, Mark D AU - Dubowitz, Howard AU - English, Diana AD - National Center for Injury Prevention and Control ; San Diego State University ; Health Resources and Services Administration ; National Institutes of Health ; University of North Carolina, Chapel Hill ; University of Maryland ; University of Washington Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2217 EP - 2228 VL - 24 IS - 8 SN - 1062-1024, 1062-1024 KW - Sociology KW - Sexuality KW - Sexual behaviour KW - Conceptualization KW - Juvenile delinquency KW - Mediation KW - Modelling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704341468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+family+studies&rft.atitle=Sexualized+behaviors+partially+mediate+the+link+between+maltreatment+and+delinquent+behaviors&rft.au=Merrick%2C+Melissa+T%3BLitrownik%2C+Alan+J%3BMargolis%2C+Benyamin%3BWiley%2C+Tisha+R.A.%3BEverson%2C+Mark+D%3BDubowitz%2C+Howard%3BEnglish%2C+Diana&rft.aulast=Merrick&rft.aufirst=Melissa&rft.date=2015-08-01&rft.volume=24&rft.issue=8&rft.spage=2217&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+family+studies&rft.issn=10621024&rft_id=info:doi/10.1007%2Fs10826-014-0024-3 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - 7039 3364 11893 11979; 7869 2703 2698; 11563 1025 1542 11325 6071; 2688 2449 10404; 8162 8163; 11579 11538 DO - http://dx.doi.org/10.1007/s10826-014-0024-3 ER - TY - JOUR T1 - Sexualized Behaviors Partially Mediate the Link between Maltreatment and Delinquent Behaviors AN - 1703894193 AB - The link between child maltreatment and juvenile delinquency has been well established, yet the underlying mechanisms through which the relationship may be explained are not very well understood. Although sexualized behaviors have been most studied in the context of sexual abuse, increasing evidence suggests that a broader conceptualization is warranted. Therefore, the current study tested sexualized behaviors as a mediator in the relation between child maltreatment of any type and delinquent behaviors using structural equation modeling. This study used a multi-site prospective sample of 804 children who were at high-risk for experiencing maltreatment and part of the Longitudinal Studies of Child Abuse and Neglect consortium. This study found that reported maltreatment was related to delinquency, and sexualized behaviors partially mediated the relationship between child maltreatment and juvenile delinquency. Specifically, children with more maltreatment reports before age 8 had increased sexualized behaviors at age 8, which in turn predicted greater delinquent behaviors at age 12. These results suggest that in addition to maltreatment experiences, early sexualized behaviors (i.e., at age 8) may also be markers for subsequent delinquent behaviors (i.e., at age 12). Researchers and clinicians should work to further clarify the connections among child maltreatment, sexualized behaviors, and delinquency. JF - Journal of Child and Family Studies AU - Litrownik, Alan J AU - Margolis, Benyamin AU - Wiley, Tisha R A AU - Everson, Mark D AU - Dubowitz, Howard AU - English, Diana AD - Department of Psychology, San Diego State University, San Diego, CA, USA ; Division of Home Visiting and Early Childhood Systems, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, USA ; Office of Behavioral and Social Science Research, National Institutes of Health, Bethesda, MD, USA ; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ; Department of Pediatrics, University of Maryland, College Park, MD, USA ; School of Social Work, University of Washington, Seattle, WA, USA ; Merrick, Melissa T; Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2217 EP - 2228 CY - New York PB - Springer Science & Business Media VL - 24 IS - 8 SN - 1062-1024 KW - Psychology KW - Juvenile Delinquency KW - Child neglect KW - Maltreated children KW - Maltreatment KW - Sexual abuse KW - Children KW - Child Neglect KW - Child Sexual Abuse KW - Risk KW - Abused children KW - Age KW - Behaviour KW - Child abuse KW - Child maltreatment KW - Conceptualization KW - Delinquency KW - High risk KW - Juvenile offenders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703894193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+and+Family+Studies&rft.atitle=Sexualized+Behaviors+Partially+Mediate+the+Link+between+Maltreatment+and+Delinquent+Behaviors&rft.au=Merrick%2C+Melissa+T%3BLitrownik%2C+Alan+J%3BMargolis%2C+Benyamin%3BWiley%2C+Tisha+R+A%3BEverson%2C+Mark+D%3BDubowitz%2C+Howard%3BEnglish%2C+Diana&rft.aulast=Merrick&rft.aufirst=Melissa&rft.date=2015-08-01&rft.volume=24&rft.issue=8&rft.spage=2217&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+and+Family+Studies&rft.issn=10621024&rft_id=info:doi/10.1007%2Fs10826-014-0024-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-08-13 N1 - Last updated - 2016-05-16 DO - http://dx.doi.org/10.1007/s10826-014-0024-3 ER - TY - JOUR T1 - Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury. AN - 1701892321; 25932872 AB - Identification of signaling pathways that are functional in a specific biological context is a major challenge in systems biology, and could be instrumental to the study of complex diseases and various aspects of drug discovery. Recent approaches have attempted to combine gene expression data with prior knowledge of protein connectivity in the form of a PPI network, and employ computational methods to identify subsets of the protein-protein-interaction (PPI) network that are functional, based on the data at hand. However, the use of undirected networks limits the mechanistic insight that can be drawn, since it does not allow for following mechanistically signal transduction from one node to the next. To address this important issue, we used a directed, signaling network as a scaffold to represent protein connectivity, and implemented an Integer Linear Programming (ILP) formulation to model the rules of signal transduction from one node to the next in the network. We then optimized the structure of the network to best fit the gene expression data at hand. We illustrated the utility of ILP modeling with a case study of drug induced lung injury. We identified the modes of action of 200 lung toxic drugs based on their gene expression profiles and, subsequently, merged the drug specific pathways to construct a signaling network that captured the mechanisms underlying Drug Induced Lung Disease (DILD). We further demonstrated the predictive power and biological relevance of the DILD network by applying it to identify drugs with relevant pharmacological mechanisms for treating lung injury. JF - Integrative biology : quantitative biosciences from nano to macro AU - Melas, Ioannis N AU - Sakellaropoulos, Theodore AU - Iorio, Francesco AU - Alexopoulos, Leonidas G AU - Loh, Wei-Yin AU - Lauffenburger, Douglas A AU - Saez-Rodriguez, Julio AU - Bai, Jane P F AD - Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. jane.bai@fda.hhs.gov. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 904 EP - 920 VL - 7 IS - 8 KW - Proteome KW - 0 KW - Index Medicus KW - Humans KW - Signal Transduction -- drug effects KW - Drug-Related Side Effects and Adverse Reactions -- etiology KW - Protein Interaction Mapping -- methods KW - Drug-Related Side Effects and Adverse Reactions -- metabolism KW - Metabolic Networks and Pathways -- drug effects KW - Lung Injury -- metabolism KW - Lung Injury -- chemically induced KW - Proteome -- metabolism KW - Lung -- drug effects KW - Lung -- metabolism KW - Models, Biological KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701892321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrative+biology+%3A+quantitative+biosciences+from+nano+to+macro&rft.atitle=Identification+of+drug-specific+pathways+based+on+gene+expression+data%3A+application+to+drug+induced+lung+injury.&rft.au=Melas%2C+Ioannis+N%3BSakellaropoulos%2C+Theodore%3BIorio%2C+Francesco%3BAlexopoulos%2C+Leonidas+G%3BLoh%2C+Wei-Yin%3BLauffenburger%2C+Douglas+A%3BSaez-Rodriguez%2C+Julio%3BBai%2C+Jane+P+F&rft.aulast=Melas&rft.aufirst=Ioannis&rft.date=2015-08-01&rft.volume=7&rft.issue=8&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Integrative+biology+%3A+quantitative+biosciences+from+nano+to+macro&rft.issn=1757-9708&rft_id=info:doi/10.1039%2Fc4ib00294f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-02 N1 - Date created - 2015-08-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1039/c4ib00294f ER - TY - JOUR T1 - Chemometric Model Development and Comparison of Raman and super(13)C Solid-State Nuclear Magnetic Resonance-Chemometric Methods for Quantification of Crystalline/Amorphous Warfarin Sodium Fraction in the Formulations AN - 1701504269; PQ0001762012 AB - Warfarin sodium (WS) exists in multiple solid-state forms. The solid-state forms differ in physicochemical properties, and crystalline changes in the drug formulation may influence on the drug product quality and/or clinical performance. It is, therefore, critically important to have a good and reliable analytical method to monitor and quantitate this transformation during stability studies. The aim of the present research was to investigate Raman spectroscopy and solid-state nuclear magnetic resonance ( super(13)C ssNMR) methods in conjunction with chemometry to quantitate the amorphous and crystalline WS fractions in the drug products. Compositionally identical formulations of amorphous and crystalline WS were prepared, and mixed in various proportions to make 0%-100% amorphous/crystalline sample matrices. Raman and super(13)C ssNMR spectra were collected and subjected to partial-least-squares and principle component regressions after mathematical treatment of the data. The model performance parameters such as root-mean-square error of prediction, standard error of prediction, and bias were low for Raman models in comparison to super(13)C ssNMR models. Models predicted values of the independent sample matrices match closely with the actual values at high level of crystalline WS. Thus, the developed methods provide means to control and quantitate the WS forms fraction in the drug product. 104:2550-2558, 2015 JF - Journal of Pharmaceutical Sciences AU - Rahman, Ziyaur AU - Mohammad, Adil AU - Akhtar, Sohail AU - Siddiqui, Akhtar AU - Korang-Yeboah, Maxwell AU - Khan, Mansoor A AD - Division of Product Quality and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland. Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2550 EP - 2558 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 8 SN - 0022-3549, 0022-3549 KW - Toxicology Abstracts KW - Sodium KW - Transformation KW - Raman spectroscopy KW - Mathematical models KW - Data processing KW - Physicochemical properties KW - N.M.R. KW - Warfarin KW - Drugs KW - Models KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701504269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Chemometric+Model+Development+and+Comparison+of+Raman+and+super%2813%29C+Solid-State+Nuclear+Magnetic+Resonance-Chemometric+Methods+for+Quantification+of+Crystalline%2FAmorphous+Warfarin+Sodium+Fraction+in+the+Formulations&rft.au=Rahman%2C+Ziyaur%3BMohammad%2C+Adil%3BAkhtar%2C+Sohail%3BSiddiqui%2C+Akhtar%3BKorang-Yeboah%2C+Maxwell%3BKhan%2C+Mansoor+A&rft.aulast=Rahman&rft.aufirst=Ziyaur&rft.date=2015-08-01&rft.volume=104&rft.issue=8&rft.spage=2550&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24524 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Transformation; Sodium; Raman spectroscopy; Data processing; Mathematical models; Physicochemical properties; N.M.R.; Warfarin; Drugs; Models DO - http://dx.doi.org/10.1002/jps.24524 ER - TY - JOUR T1 - Chemoprophylaxis and vaccination in preventing subsequent cases of meningococcal disease in household contacts of a case of meningococcal disease: a systematic review AN - 1701502233; PQ0001725286 AB - Household contacts of an index case of invasive meningococcal disease (IMD) are at increased risk of acquiring disease. In revising WHO guidance on IMD in sub-Saharan Africa, a systematic review was undertaken to assess the effect of chemoprophylaxis and of vaccination in preventing subsequent cases of IMD in household contacts following an index case. A literature search for systematic reviews identified a single suitable review on chemoprophylaxis in 2004 (three studies meta-analysed). A search for primary research papers published since 2004 on chemoprophylaxis and without a date limit on vaccination was therefore undertaken. There were 2381 studies identified of which two additional studies met the inclusion criteria. The summary risk ratio for chemoprophylaxis vs. no chemoprophylaxis (four studies) in the 30-day period after a case was 0.16 [95% confidence interval (CI) 0.04-0.64, P = 0.008]; the number needed to treat to prevent one subsequent case was 200 (95% CI 111-1000). A single quasi-randomized trial assessed the role of vaccination. The risk ratio for vaccination vs. no vaccination at 30 days was 0.11 (95% CI 0.01-2.07, P = 0.14). The results support the use of chemoprophylaxis to prevent subsequent cases of IMD in household contacts of a case. Conclusions about the use of vaccination could not be drawn. JF - Epidemiology and Infection AU - TELISINGHE, L AU - Waite, T D AU - Gobin, M AU - Ronveaux, O AU - Fernandez, K AU - Stuart, J M AU - SCHOLTEN, RJPM AD - Field Epidemiology Services, Public Health England, Bristol, UK, lily.telisinghe@phe.gov.uk Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 2259 EP - 2268 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 11 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Risk assessment KW - meningococcal disease KW - Reviews KW - Invasive meningococcal disease KW - Africa KW - Neisseria meningitidis KW - Vaccines KW - Vaccination KW - J 02310:Genetics & Taxonomy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701502233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Chemoprophylaxis+and+vaccination+in+preventing+subsequent+cases+of+meningococcal+disease+in+household+contacts+of+a+case+of+meningococcal+disease%3A+a+systematic+review&rft.au=TELISINGHE%2C+L%3BWaite%2C+T+D%3BGobin%2C+M%3BRonveaux%2C+O%3BFernandez%2C+K%3BStuart%2C+J+M%3BSCHOLTEN%2C+RJPM&rft.aulast=TELISINGHE&rft.aufirst=L&rft.date=2015-08-01&rft.volume=143&rft.issue=11&rft.spage=2259&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268815000849 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 28 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - meningococcal disease; Invasive meningococcal disease; Vaccination; Risk assessment; Reviews; Vaccines; Neisseria meningitidis; Africa DO - http://dx.doi.org/10.1017/S0950268815000849 ER - TY - CONF T1 - Current Research and Opportunities to Address Environmental Asbestos Exposures. AN - 1701300214; 26230287 AB - Asbestos-related diseases continue to result in approximately 120,000 deaths every year in the United States and worldwide. Although extensive research has been conducted on health effects of occupational exposures to asbestos, many issues related to environmental asbestos exposures remain unresolved. For example, environmental asbestos exposures associated with a former mine in Libby, Montana, have resulted in high rates of nonoccupational asbestos-related disease. Additionally, other areas with naturally occurring asbestos deposits near communities in the United States and overseas are undergoing investigations to assess exposures and potential health risks. Some of the latest public health, epidemiological, and basic research findings were presented at a workshop on asbestos at the 2014 annual meeting of the Society of Toxicology in Phoenix, Arizona. The following focus areas were discussed: a) mechanisms resulting in fibrosis and/or tumor development; b) relative toxicity of different forms of asbestos and other hazardous elongated mineral particles (EMPs); c) proper dose metrics (e.g., mass, fiber number, or surface area of fibers) when interpreting asbestos toxicity; d) asbestos exposure to susceptible populations; and e) using toxicological findings for risk assessment and remediation efforts. The workshop also featured asbestos research supported by the National Institute of Environmental Health Sciences, the Agency for Toxic Substances and Disease Registry, and the U.S. Environmental Protection Agency. Better protection of individuals from asbestos-related health effects will require stimulation of new multidisciplinary research to further our understanding of what constitutes hazardous exposures and risk factors associated with toxicity of asbestos and other hazardous EMPs (e.g., nanomaterials). JF - Environmental health perspectives AU - Carlin, Danielle J AU - Larson, Theodore C AU - Pfau, Jean C AU - Gavett, Stephen H AU - Shukla, Arti AU - Miller, Aubrey AU - Hines, Ronald Y1 - 2015/08// PY - 2015 DA - August 2015 SP - A194 EP - A197 VL - 123 IS - 8 KW - Environmental Pollutants KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Humans KW - Environmental Restoration and Remediation KW - Risk Assessment KW - Environmental Pollutants -- toxicity KW - Environmental Exposure KW - Asbestos -- toxicity KW - Asbestosis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701300214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Environmental+health+perspectives&rft.atitle=Current+Research+and+Opportunities+to+Address+Environmental+Asbestos+Exposures.&rft.au=Carlin%2C+Danielle+J%3BLarson%2C+Theodore+C%3BPfau%2C+Jean+C%3BGavett%2C+Stephen+H%3BShukla%2C+Arti%3BMiller%2C+Aubrey%3BHines%2C+Ronald&rft.aulast=Carlin&rft.aufirst=Danielle&rft.date=2015-08-01&rft.volume=123&rft.issue=8&rft.spage=A194&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1409662 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-17 N1 - Date created - 2015-08-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health. 2014;13:59 [25043725] J Toxicol Environ Health A. 2015;78(3):151-65 [25506632] J Occup Environ Med. 2015 Jan;57(1):6-13 [25563535] Occup Environ Med. 2015 Mar;72(3):216-8 [25231672] Am J Ind Med. 2015 May;58(5):494-508 [25675894] J Thorac Oncol. 2015 May;10(5):731-7 [25668121] Curr Probl Diagn Radiol. 2015 Jul-Aug;44(4):371-82 [25444537] Arthritis Rheum. 2002 Jun;46(6):1602-13 [12115192] Mol Cell. 2002 Aug;10(2):417-26 [12191486] Environ Health Perspect. 2003 Nov;111(14):1753-9 [14594627] Am J Ind Med. 2014 Nov;57(11):1197-206 [24898907] Am J Respir Crit Care Med. 2004 Sep 15;170(6):691-715 [15355871] Am Rev Respir Dis. 1984 Jun;129(6):952-8 [6329050] Occup Environ Med. 1997 Sep;54(9):646-52 [9423577] Environ Health Perspect. 2005 Jan;113(1):25-30 [15626643] Environ Health Perspect. 2006 Aug;114(8):1243-7 [16882533] Am J Respir Crit Care Med. 2008 Mar 15;177(6):630-7 [18063841] Science. 2008 May 2;320(5876):674-7 [18403674] Am J Ind Med. 2008 Nov;51(11):877-80 [18651576] Radiology. 2010 Jun;255(3):924-33 [20501730] Environ Health Perspect. 2010 Jul;118(7):1033-28 [20332072] Environ Health Perspect. 2010 Jul;118(7):897-901 [20601329] Environ Health Perspect. 2010 Jul;118(7):A298-303 [20601321] Int J Occup Environ Health. 2010 Jul-Sep;16(3):279-90 [20662420] Toxicol Sci. 2010 Dec;118(2):420-34 [20855422] Inhal Toxicol. 2011 Feb;23(3):129-41 [21391781] J Immunotoxicol. 2011 Jun;8(2):159-69 [21457077] Inhal Toxicol. 2011 May;23(6):313-23 [21605006] J Toxicol Environ Health A. 2011;74(17):1111-32 [21797767] Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13618-23 [21788493] Environ Health Perspect. 2011 Dec;119(12):1806-10 [21807578] Toxicol Lett. 2012 Jan 25;208(2):168-73 [22085844] Environ Health Perspect. 2012 Jan;120(1):85-91 [21979745] J Toxicol Environ Health A. 2012;75(3):183-200 [22251266] Toxicol Sci. 2012 Dec;130(2):405-15 [22903825] Am J Ind Med. 2013 Feb;56(2):133-45 [22886909] Int J Cancer. 2013 Mar 15;132(6):1423-8 [22858896] Environ Geochem Health. 2013 Aug;35(4):419-30 [23315055] Part Fibre Toxicol. 2013;10:39 [23937860] Inhal Toxicol. 2013 Dec;25(14):774-84 [24304304] Part Fibre Toxicol. 2014;11:2 [24401117] Toxicol Appl Pharmacol. 2014 Mar 15;275(3):257-64 [24518925] Part Fibre Toxicol. 2014;11:24 [24885895] J Immunotoxicol. 2014 Jul-Sep;11(3):283-90 [24164284] J Expo Sci Environ Epidemiol. 2015 Jan;25(1):4-11 [23695492] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1409662 ER - TY - JOUR T1 - Effect of Fill Temperature on Clostridium botulinum Type A Toxin Activity during the Hot Filling of Juice Bottles. AN - 1700335894; 26219364 AB - The potential threat of terrorist attacks against the United States food supply using neurotoxin produced by Clostridium botulinum (BoNT) has resulted in the need for studying the effect of various food process operations on the bioavailability of this toxin. The objective of this study was to evaluate C. botulinum type A neurotoxin bioavailability after a simulated hot fill juice bottling operation. C. botulinum type A acid mud toxin (∼10(6) mouse lethal dose [MLD50]/ml) was deposited into juice bottles at an experimentally determined fastest cooling spot. Bottles (12 or 20 oz [355 and 592 ml]) were filled with either apple juice or an orange drink, at 80 or 85°C, in either upright or inverted orientations. Toxicity of the juice was evaluated as a function of holding time (1 to 2 min) by the mouse bioassay. The fastest cooling point in the upright orientation was determined to be at a bottle's bottom rim. In the inverted orientation, the fastest cooling point was in the bottle cap region. With respect to these two points, the upright bottle cooled faster than the inverted bottle, which was reflected in a higher inactivation of BoNT in the latter. For the orange drink (pH 2.9) toxicity was reduced by 0.5 × 10(6) MLD50/ml to a nondetectable level after 1 min in all bottle sizes, orientations, and temperatures as measured by the mouse bioassay. This indicates that there was at least a 0.5 × 10(6) MLD50/ml reduction in activity. Inactivation in apple juice (pH 4.0), to the same degree as in the orange drink, was found only for the inverted orientation at 85°C. Complete inactivation in apple juice for all conditions was found at a lower added toxin level of 0.25 × 10(5) MLD50/ml. In general, bottle inversion and filling at 85°C provided complete inactivation of BoNT to the 0.5 × 10(6) MLD50/ml level. All experiments resulted in the inactivation of 2.5 × 10(4) MLD50/ml of BoNT regardless of juice type, fill temperature, or bottle orientation and size. JF - Journal of food protection AU - Skinner, Guy E AU - Fleischman, Gregory J AU - Balster, Fran AU - Reineke, Karl AU - Reddy, N Rukma AU - Larkin, John W AD - U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, Illinois 60501, USA; U.S. Food and Drug Administration, Institute for Food Safety and Health (IFSH), 6502 South Archer Road, Bedford Park, Illinois 60501, US. guy.skinner@fda.hhs.gov. ; U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, Illinois 60501, USA; U.S. Food and Drug Administration, Institute for Food Safety and Health (IFSH), 6502 South Archer Road, Bedford Park, Illinois 60501, US. ; Institute for Food Safety and Health (IFSH), Illinois Institute of Technology (IIT), 6502 South Archer Road, Bedford Park, Illinois 60501, USA; Illinois Department of Public Health (IFPH), 2121 Taylor Street, Chicago, IL 60612, USA. ; U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, Illinois 60501, USAU.S. Food and Drug Administration, Institute for Food Safety and Health (IFSH), 6502 South Archer Road, Bedford Park, Illinois 60501, US. ; U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, Illinois 60501, USA; U.S. Food and Drug Administration, Institute for Food Safety and Health (IFSH), 6502 South Archer Road, Bedford Park, Illinois 60501; US National Center for Food Protection and Defense, Learning and Environmental Sciences Building, University of Minnesota, 1954 Buford Avenue, St. Paul, MN 55108, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1506 EP - 1511 VL - 78 IS - 8 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - Food Contamination -- prevention & control KW - Citrus sinensis KW - Animals KW - Food Microbiology KW - Hydrogen-Ion Concentration KW - Toxicity Tests KW - Lethal Dose 50 KW - Biological Assay KW - Malus KW - Mice KW - Hot Temperature KW - Food Handling -- methods KW - Fruit and Vegetable Juices -- microbiology KW - Clostridium botulinum type A -- isolation & purification KW - Botulinum Toxins, Type A -- analysis KW - Clostridium botulinum type A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700335894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Effect+of+Fill+Temperature+on+Clostridium+botulinum+Type+A+Toxin+Activity+during+the+Hot+Filling+of+Juice+Bottles.&rft.au=Skinner%2C+Guy+E%3BFleischman%2C+Gregory+J%3BBalster%2C+Fran%3BReineke%2C+Karl%3BReddy%2C+N+Rukma%3BLarkin%2C+John+W&rft.aulast=Skinner&rft.aufirst=Guy&rft.date=2015-08-01&rft.volume=78&rft.issue=8&rft.spage=1506&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=1944-9097&rft_id=info:doi/10.4315%2F0362-028X.JFP-14-378 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-25 N1 - Date created - 2015-07-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.4315/0362-028X.JFP-14-378 ER - TY - JOUR T1 - Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. AN - 1700333315; 26098869 AB - Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10(-14)), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10(-8)) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10(-8)). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10(-9)), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk. JF - Nature genetics AU - Childs, Erica J AU - Mocci, Evelina AU - Campa, Daniele AU - Bracci, Paige M AU - Gallinger, Steven AU - Goggins, Michael AU - Li, Donghui AU - Neale, Rachel E AU - Olson, Sara H AU - Scelo, Ghislaine AU - Amundadottir, Laufey T AU - Bamlet, William R AU - Bijlsma, Maarten F AU - Blackford, Amanda AU - Borges, Michael AU - Brennan, Paul AU - Brenner, Hermann AU - Bueno-de-Mesquita, H Bas AU - Canzian, Federico AU - Capurso, Gabriele AU - Cavestro, Giulia M AU - Chaffee, Kari G AU - Chanock, Stephen J AU - Cleary, Sean P AU - Cotterchio, Michelle AU - Foretova, Lenka AU - Fuchs, Charles AU - Funel, Niccola AU - Gazouli, Maria AU - Hassan, Manal AU - Herman, Joseph M AU - Holcatova, Ivana AU - Holly, Elizabeth A AU - Hoover, Robert N AU - Hung, Rayjean J AU - Janout, Vladimir AU - Key, Timothy J AU - Kupcinskas, Juozas AU - Kurtz, Robert C AU - Landi, Stefano AU - Lu, Lingeng AU - Malecka-Panas, Ewa AU - Mambrini, Andrea AU - Mohelnikova-Duchonova, Beatrice AU - Neoptolemos, John P AU - Oberg, Ann L AU - Orlow, Irene AU - Pasquali, Claudio AU - Pezzilli, Raffaele AU - Rizzato, Cosmeri AU - Saldia, Amethyst AU - Scarpa, Aldo AU - Stolzenberg-Solomon, Rachael Z AU - Strobel, Oliver AU - Tavano, Francesca AU - Vashist, Yogesh K AU - Vodicka, Pavel AU - Wolpin, Brian M AU - Yu, Herbert AU - Petersen, Gloria M AU - Risch, Harvey A AU - Klein, Alison P AD - Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA. ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. ; 1] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] Department of Biology, University of Pisa, Pisa, Italy. ; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. ; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. ; Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ; Department of Population Health, QIMR Berghofer Medical Research Institute, Kelvin Grove,Queensland, Australia. ; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA. ; International Agency for Research on Cancer (IARC), Lyon, France. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA. ; Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. ; Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. ; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. ; 1] Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. [2] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, the Netherlands. [3] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. [4] Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. ; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. ; Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome, Italy. ; Università Vita Salute San Raffaele and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milan, Italy. ; 1] Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada. [2] Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada. ; 1] Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada. [2] Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. ; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and Medical Faculty Masaryk University, Brno, Czech Republic. ; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. ; Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy. ; Department of Medical Sciences, Laboratory of Biology, School of Medicine, University of Athens, Athens, Greece. ; Department of Radiation Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. ; Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. ; Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic. ; Cancer Epidemiology Unit, University of Oxford, Oxford, UK. ; Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania. ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. ; Department of Biology, Section of Genetics, University of Pisa, Pisa, Italy. ; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA. ; Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland. ; Department of Oncology, Azienda USL 1 Massa Carrara, Massa Carrara, Italy. ; Laboratory of Toxicogenomics, Institute of Public Health, Prague, Czech Republic. ; National Institute for Health Research (NIHR) Pancreas Biomedical Research Unit, Liverpool Clinical Trials Unit and Cancer Research UK Clinical Trials Unit, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. ; Department of Surgery, Gastroenterology and Oncology, University of Padua, Padua, Italy. ; Pancreas Unit, Department of Digestive Diseases, Sant'Orsola-Malpighi Hospital, Bologna, Italy. ; ARC-NET-Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy. ; Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA. ; Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany. ; Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Italy. ; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences, Prague, Czech Republic. ; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. ; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA. ; 1] Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. [2] Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 911 EP - 916 VL - 47 IS - 8 KW - Index Medicus KW - North America KW - Gene Frequency KW - Humans KW - Aged KW - Europe KW - Genome-Wide Association Study -- methods KW - Genotype KW - Risk Factors KW - Australia KW - Genetic Loci -- genetics KW - Middle Aged KW - Female KW - Male KW - Polymorphism, Single Nucleotide KW - Genetic Predisposition to Disease -- genetics KW - Chromosomes, Human, Pair 3 -- genetics KW - Pancreatic Neoplasms -- genetics KW - Chromosomes, Human, Pair 7 -- genetics KW - Chromosomes, Human, Pair 2 -- genetics KW - Chromosomes, Human, Pair 17 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700333315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+genetics&rft.atitle=Common+variation+at+2p13.3%2C+3q29%2C+7p13+and+17q25.1+associated+with+susceptibility+to+pancreatic+cancer.&rft.au=Childs%2C+Erica+J%3BMocci%2C+Evelina%3BCampa%2C+Daniele%3BBracci%2C+Paige+M%3BGallinger%2C+Steven%3BGoggins%2C+Michael%3BLi%2C+Donghui%3BNeale%2C+Rachel+E%3BOlson%2C+Sara+H%3BScelo%2C+Ghislaine%3BAmundadottir%2C+Laufey+T%3BBamlet%2C+William+R%3BBijlsma%2C+Maarten+F%3BBlackford%2C+Amanda%3BBorges%2C+Michael%3BBrennan%2C+Paul%3BBrenner%2C+Hermann%3BBueno-de-Mesquita%2C+H+Bas%3BCanzian%2C+Federico%3BCapurso%2C+Gabriele%3BCavestro%2C+Giulia+M%3BChaffee%2C+Kari+G%3BChanock%2C+Stephen+J%3BCleary%2C+Sean+P%3BCotterchio%2C+Michelle%3BForetova%2C+Lenka%3BFuchs%2C+Charles%3BFunel%2C+Niccola%3BGazouli%2C+Maria%3BHassan%2C+Manal%3BHerman%2C+Joseph+M%3BHolcatova%2C+Ivana%3BHolly%2C+Elizabeth+A%3BHoover%2C+Robert+N%3BHung%2C+Rayjean+J%3BJanout%2C+Vladimir%3BKey%2C+Timothy+J%3BKupcinskas%2C+Juozas%3BKurtz%2C+Robert+C%3BLandi%2C+Stefano%3BLu%2C+Lingeng%3BMalecka-Panas%2C+Ewa%3BMambrini%2C+Andrea%3BMohelnikova-Duchonova%2C+Beatrice%3BNeoptolemos%2C+John+P%3BOberg%2C+Ann+L%3BOrlow%2C+Irene%3BPasquali%2C+Claudio%3BPezzilli%2C+Raffaele%3BRizzato%2C+Cosmeri%3BSaldia%2C+Amethyst%3BScarpa%2C+Aldo%3BStolzenberg-Solomon%2C+Rachael+Z%3BStrobel%2C+Oliver%3BTavano%2C+Francesca%3BVashist%2C+Yogesh+K%3BVodicka%2C+Pavel%3BWolpin%2C+Brian+M%3BYu%2C+Herbert%3BPetersen%2C+Gloria+M%3BRisch%2C+Harvey+A%3BKlein%2C+Alison+P&rft.aulast=Childs&rft.aufirst=Erica&rft.date=2015-08-01&rft.volume=47&rft.issue=8&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Nature+genetics&rft.issn=1546-1718&rft_id=info:doi/10.1038%2Fng.3341 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-26 N1 - Date created - 2015-07-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Genet. 2012 Dec;44(12):1330-5 [23143601] Nat Genet. 2007 Oct;39(10):1181-6 [17898773] Nat Methods. 2013 Jan;10(1):5-6 [23269371] Dig Liver Dis. 2013 Feb;45(2):95-9 [23206934] Nature. 2013 Apr 4;496(7443):101-5 [23535601] Cancer Epidemiol. 2013 Dec;37(6):886-92 [24075798] Nucleic Acids Res. 2014 Jan;42(Database issue):D975-9 [24297256] J Inherit Metab Dis. 2014 Jan;37(1):13-9 [23893049] Hum Mol Genet. 2014 Mar 1;23(5):1387-98 [24163127] Int J Cancer. 2000 Sep 15;87(6):809-11 [10956390] J Natl Cancer Inst. 2002 Sep 18;94(18):1358-65 [12237281] J Natl Cancer Inst. 2003 Jul 2;95(13):948-60 [12837831] Cancer Res. 2004 Apr 1;64(7):2634-8 [15059921] Br J Cancer. 1985 Aug;52(2):271-3 [4027169] Mol Carcinog. 1993;8(4):214-20 [8280369] Int J Cancer. 2007 Nov 15;121(10):2241-5 [17582608] Am J Gastroenterol. 2007 Dec;102(12):2696-707 [17764494] Cancer Detect Prev. 2007;31(5):345-51 [18031948] Langenbecks Arch Surg. 2008 Jul;393(4):535-45 [18193270] Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1470-9 [18559563] Cancer Res. 2008 Jun 15;68(12):4928-35 [18544627] Science. 2009 Apr 10;324(5924):217 [19264984] Nat Genet. 2009 Sep;41(9):986-90 [19648918] J Natl Cancer Inst. 2010 Jan 20;102(2):119-26 [20068195] Eur J Cancer. 2010 Jan;46(2):370-6 [19782561] Nat Genet. 2010 Mar;42(3):224-8 [20101243] Am J Gastroenterol. 2010 Jun;105(6):1258-64; author reply 1265 [20051941] Nat Genet. 2010 Jul;42(7):579-89 [20581827] PLoS One. 2010;5(7):e11824 [20686608] Bioinformatics. 2010 Sep 1;26(17):2190-1 [20616382] Nature. 2010 Sep 2;467(7311):52-8 [20811451] Nat Genet. 2010 Oct;42(10):893-6 [20871597] Nat Genet. 2010 Nov;42(11):978-84 [20972438] Cancer Causes Control. 2011 Feb;22(2):189-97 [21104117] Am J Hum Genet. 2011 Mar 11;88(3):294-305 [21376301] Nat Rev Genet. 2010 Jul;11(7):499-511 [20517342] Cancer Res. 2011 Jul 1;71(13):4352-8 [21498636] Cell Death Differ. 2011 Sep;18(9):1487-99 [21760596] Int J Cancer. 2011 Dec 15;129(12):2875-84 [21520034] PLoS One. 2011;6(10):e26815 [22053213] Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 [22064851] Nat Genet. 2012 Jan;44(1):62-6 [22158540] Carcinogenesis. 2012 Apr;33(4):818-27 [22301281] Cancer Discov. 2012 Jan;2(1):41-6 [22585167] Carcinogenesis. 2012 Jul;33(7):1384-90 [22523087] Nat Genet. 2012 Aug;44(8):900-3 [22797724] Nat Genet. 2012 Aug;44(8):955-9 [22820512] Nature. 2012 Nov 1;491(7422):56-65 [23128226] Int J Clin Exp Pathol. 2014;7(7):4531-8 [25120849] Nat Genet. 2014 Sep;46(9):994-1000 [25086665] Bioinformatics. 2012 Dec 15;28(24):3326-8 [23060615] JAMA. 1995 May 24-31;273(20):1605-9 [7745774] Arch Intern Med. 1996 Oct 28;156(19):2255-60 [8885826] Nature. 1996 Dec 5;384(6608):455-8 [8945470] Nature. 1996 Dec 5;384(6608):458-60 [8945471] Cancer Res. 1996 Dec 1;56(23):5360-4 [8968085] J Clin Endocrinol Metab. 1999 Mar;84(3):1077-82 [10084598] Cancer Cell. 2005 Apr;7(4):363-73 [15837625] Gastroenterology. 2005 Aug;129(2):504-11 [16083707] Cancer Immunol Immunother. 2006 Apr;55(4):363-74 [16003559] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] Carcinogenesis. 2014 Dec;35(12):2670-8 [25233928] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/ng.3341 ER - TY - JOUR T1 - Quality control metrics improve repeatability and reproducibility of single-nucleotide variants derived from whole-genome sequencing. AN - 1698960809; 25384574 AB - Although many quality control (QC) methods have been developed to improve the quality of single-nucleotide variants (SNVs) in SNV-calling, QC methods for use subsequent to single-nucleotide polymorphism-calling have not been reported. We developed five QC metrics to improve the quality of SNVs using the whole-genome-sequencing data of a monozygotic twin pair from the Korean Personal Genome Project. The QC metrics improved both repeatability between the monozygotic twin pair and reproducibility between SNV-calling pipelines. We demonstrated the QC metrics improve reproducibility of SNVs derived from not only whole-genome-sequencing data but also whole-exome-sequencing data. The QC metrics are calculated based on the reference genome used in the alignment without accessing the raw and intermediate data or knowing the SNV-calling details. Therefore, the QC metrics can be easily adopted in downstream association analysis. JF - The pharmacogenomics journal AU - Zhang, W AU - Soika, V AU - Meehan, J AU - Su, Z AU - Ge, W AU - Ng, H W AU - Perkins, R AU - Simonyan, V AU - Tong, W AU - Hong, H AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. ; Office of The Center Director, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 298 EP - 309 VL - 15 IS - 4 KW - Index Medicus KW - Republic of Korea KW - Base Sequence KW - Reproducibility of Results KW - Twins, Monozygotic KW - Humans KW - Algorithms KW - Quality Control KW - Chromosome Mapping KW - High-Throughput Nucleotide Sequencing KW - Genome-Wide Association Study -- standards KW - Genome, Human -- genetics KW - Polymorphism, Single Nucleotide -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698960809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+pharmacogenomics+journal&rft.atitle=Quality+control+metrics+improve+repeatability+and+reproducibility+of+single-nucleotide+variants+derived+from+whole-genome+sequencing.&rft.au=Zhang%2C+W%3BSoika%2C+V%3BMeehan%2C+J%3BSu%2C+Z%3BGe%2C+W%3BNg%2C+H+W%3BPerkins%2C+R%3BSimonyan%2C+V%3BTong%2C+W%3BHong%2C+H&rft.aulast=Zhang&rft.aufirst=W&rft.date=2015-08-01&rft.volume=15&rft.issue=4&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=The+pharmacogenomics+journal&rft.issn=1473-1150&rft_id=info:doi/10.1038%2Ftpj.2014.70 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-19 N1 - Date created - 2015-07-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/tpj.2014.70 ER - TY - JOUR T1 - Extracellular signal-regulated kinases 1/2 and Akt contribute to triclosan-stimulated proliferation of JB6 Cl 41-5a cells. AN - 1698030306; 25033989 AB - Triclosan is a broad spectrum anti-bacterial agent widely used in many personal care products, household items, medical devices, and clinical settings. Human exposure to triclosan is mainly through oral and dermal routes. In previous studies, we found that sub-chronic dermal exposure of B6C3F1 mice to triclosan induced epidermal hyperplasia and focal necrosis; however, the mechanisms for these responses remain elusive. In this study, using mouse epidermis-derived JB6 Cl 41-5a cells, we found that triclosan stimulated cell growth in a concentration- and time-dependent manner. Enhanced cell proliferation was demonstrated by a substantial increase in the percentage of BrdU-positive cells, an elevation in the protein levels of cyclin D1 and cyclin A, and a reduction in the protein level of p27(Kip1). Western blotting analysis revealed that triclosan induced the activation of extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinases (JNK), p38, and Akt. Pre-treatment of the cells with PD184352, an inhibitor of the upstream kinase MEK1/2, or with wortmannin, an inhibitor of phosphoinositide 3-kinase, blocked triclosan-mediated phosphorylation of ERK1/2 and Akt, respectively, and substantially suppressed triclosan-stimulated cell proliferation, whereas the JNK inhibitor SP600125 or the p38 inhibitor SB203580 had little to no effect on triclosan-stimulated cell proliferation. The phosphorylation activation of ERK1/2 and Akt was further confirmed on the skin of mice dermally administered triclosan. These data suggest that the activation of ERK1/2 and Akt is involved in triclosan-stimulated proliferation of JB6 Cl 41-5a cells. JF - Archives of toxicology AU - Wu, Yuanfeng AU - Beland, Frederick A AU - Chen, Si AU - Fang, Jia-Long AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, 72079, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1297 EP - 1311 VL - 89 IS - 8 KW - Anti-Infective Agents, Local KW - 0 KW - Enzyme Inhibitors KW - Triclosan KW - 4NM5039Y5X KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Index Medicus KW - Mice, Inbred Strains KW - Comet Assay KW - Animals KW - Blotting, Western KW - Dose-Response Relationship, Drug KW - Cell Culture Techniques KW - Enzyme Inhibitors -- pharmacology KW - Time Factors KW - Female KW - Cell Line KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Cell Proliferation -- drug effects KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors KW - Apoptosis -- drug effects KW - Anti-Infective Agents, Local -- toxicity KW - Triclosan -- toxicity KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698030306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Extracellular+signal-regulated+kinases+1%2F2+and+Akt+contribute+to+triclosan-stimulated+proliferation+of+JB6+Cl+41-5a+cells.&rft.au=Wu%2C+Yuanfeng%3BBeland%2C+Frederick+A%3BChen%2C+Si%3BFang%2C+Jia-Long&rft.aulast=Wu&rft.aufirst=Yuanfeng&rft.date=2015-08-01&rft.volume=89&rft.issue=8&rft.spage=1297&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-014-1308-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-15 N1 - Date created - 2015-07-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00204-014-1308-5 ER - TY - JOUR T1 - Drug-induced liver injury: Interactions between drug properties and host factors. AN - 1697759730; 25912521 AB - Idiosyncratic drug-induced liver injury (DILI) is a common cause for drug withdrawal from the market and although infrequent, DILI can result in serious clinical outcomes including acute liver failure and the need for liver transplantation. Eliminating the iatrogenic "harm" caused by a therapeutic intent is a priority in patient care. However, identifying culprit drugs and individuals at risk for DILI remains challenging. Apart from genetic factors predisposing individuals at risk, the role of the drugs' physicochemical and toxicological properties and their interactions with host and environmental factors need to be considered. The influence of these factors on mechanisms involved in DILI is multi-layered. In this review, we summarize current knowledge on 1) drug properties associated with hepatotoxicity, 2) host factors considered to modify an individuals' risk for DILI and clinical phenotypes, and 3) drug-host interactions. We aim at clarifying knowledge gaps needed to be filled in as to improve risk stratification in patient care. We therefore broadly discuss relevant areas of future research. Emerging insight will stimulate new investigational approaches to facilitate the discovery of clinical DILI risk modifiers in the context of disease complexity and associated interactions with drug properties, and hence will be able to move towards safety personalized medicine. Copyright © 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. JF - Journal of hepatology AU - Chen, Minjun AU - Suzuki, Ayako AU - Borlak, Jürgen AU - Andrade, Raúl J AU - Lucena, M Isabel AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, United States. ; Gastroenterology, Central Arkansas Veterans Healthcare System, Little Rock, AR, United States; Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States. ; Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. ; Unidad de Gestión Clínica de Enfermedades Digestivas, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. Electronic address: andrade@uma.es. ; Unidad de Gestión Clínica de Enfermedades Digestivas, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 503 EP - 514 VL - 63 IS - 2 KW - Index Medicus KW - Drug physicochemical properties KW - Drug clearance KW - Drug-host Interaction KW - Drug metabolism KW - Clinical toxicology KW - Host factors KW - Pharmacogenetics KW - Drug-induced liver injury KW - Risk Factors KW - Humans KW - Drug Interactions KW - Chemical and Drug Induced Liver Injury -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697759730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Drug-induced+liver+injury%3A+Interactions+between+drug+properties+and+host+factors.&rft.au=Chen%2C+Minjun%3BSuzuki%2C+Ayako%3BBorlak%2C+J%C3%BCrgen%3BAndrade%2C+Ra%C3%BAl+J%3BLucena%2C+M+Isabel&rft.aulast=Chen&rft.aufirst=Minjun&rft.date=2015-08-01&rft.volume=63&rft.issue=2&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2015.04.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-24 N1 - Date created - 2015-07-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jhep.2015.04.016 ER - TY - JOUR T1 - Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex. AN - 1697757053; 25933590 AB - Extracellular or free hemoglobin (Hb) accumulates during hemolysis, tissue damage, and inflammation. Heme-triggered oxidative reactions can lead to diverse structural modifications of lipids and proteins, which contribute to the propagation of tissue damage. One important target of Hb׳s peroxidase reactivity is its own globin structure. Amino acid oxidation and crosslinking events destabilize the protein and ultimately cause accumulation of proinflammatory and cytotoxic Hb degradation products. The Hb scavenger haptoglobin (Hp) attenuates oxidation-induced Hb degradation. In this study we show that in the presence of hydrogen peroxide (H2O2), Hb and the Hb:Hp complex share comparable peroxidative reactivity and free radical generation. While oxidation of both free Hb and Hb:Hp complex generates a common tyrosine-based free radical, the spin-trapping reaction with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) yields dissimilar paramagnetic products in Hb and Hb:Hp, suggesting that radicals are differently redistributed within the complex before reacting with the spin trap. With LC-MS(2) mass spectrometry we assigned multiple known and novel DMPO adduct sites. Quantification of these adducts suggested that the Hb:Hp complex formation causes extensive delocalization of accessible free radicals with drastic reduction of the major tryptophan and cysteine modifications in the β-globin chain of the Hb:Hp complex, including decreased βCys93 DMPO adduction. In contrast, the quantitative changes in DMPO adduct formation on Hb:Hp complex formation were less pronounced in the Hb α-globin chain. In contrast to earlier speculations, we found no evidence that free Hb radicals are delocalized to the Hp chain of the complex. The observation that Hb:Hp complex formation alters free radical distribution in Hb may help to better understand the structural basis for Hp as an antioxidant protein. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Free radical biology & medicine AU - Vallelian, Florence AU - Garcia-Rubio, Ines AU - Puglia, Michele AU - Kahraman, Abdullah AU - Deuel, Jeremy W AU - Engelsberger, Wolfgang R AU - Mason, Ronald P AU - Buehler, Paul W AU - Schaer, Dominik J AD - Division of Internal Medicine, University Hospital, Zurich, Switzerland. ; Laboratory of Physical Chemistry, ETH Zürich, Switzerland; Centro Universitario de la Defensa, carretera de Huesca, Zaragoza, Spain. ; Division of Internal Medicine, University Hospital, Zurich, Switzerland; Functional Genomics Center, University of Zurich, Switzerland. ; Institute of Molecular Life Sciences, University of Zurich, Switzerland. ; Laboratory of Toxicology & Pharmacology, NIEHS/NIH, Research Triangle Park, NC, USA. ; Center of Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA. ; Division of Internal Medicine, University Hospital, Zurich, Switzerland; Institute of Evolutionary Medicine, University of Zurich, Switzerland. Electronic address: dominik.schaer@usz.ch. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 259 EP - 268 VL - 85 KW - Amino Acids KW - 0 KW - Free Radicals KW - Haptoglobins KW - Hemoglobins KW - Hydrogen Peroxide KW - BBX060AN9V KW - Peroxidases KW - EC 1.11.1.- KW - Index Medicus KW - Hemoglobin KW - Haptoglobin KW - Oxidative stress KW - Radical KW - Oxidation KW - Spin trapping KW - Electron paramagnetic resonance (EPR) KW - Mass spectrometry KW - Oxidation-Reduction KW - Amino Acids -- chemistry KW - Humans KW - Electron Spin Resonance Spectroscopy KW - Hydrogen Peroxide -- pharmacology KW - Molecular Sequence Data KW - Chromatography, Liquid KW - Amino Acid Sequence KW - Peroxidases -- metabolism KW - Spin Trapping KW - Hemoglobins -- metabolism KW - Tandem Mass Spectrometry -- methods KW - Hemoglobins -- chemistry KW - Haptoglobins -- metabolism KW - Free Radicals -- metabolism KW - Haptoglobins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697757053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Spin+trapping+combined+with+quantitative+mass+spectrometry+defines+free+radical+redistribution+within+the+oxidized+hemoglobin%3Ahaptoglobin+complex.&rft.au=Vallelian%2C+Florence%3BGarcia-Rubio%2C+Ines%3BPuglia%2C+Michele%3BKahraman%2C+Abdullah%3BDeuel%2C+Jeremy+W%3BEngelsberger%2C+Wolfgang+R%3BMason%2C+Ronald+P%3BBuehler%2C+Paul+W%3BSchaer%2C+Dominik+J&rft.aulast=Vallelian&rft.aufirst=Florence&rft.date=2015-08-01&rft.volume=85&rft.issue=&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2015.04.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-26 N1 - Date created - 2015-07-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2015.04.023 ER - TY - JOUR T1 - Prevalence of ciguatoxins in lionfish (Pterois spp.) from Guadeloupe, Saint Martin, and Saint Barthélmy Islands (Caribbean). AN - 1695757075; 26026621 AB - Lionfish (Pterois spp.) are invasive species that have recently spread throughout the Caribbean. Lionfish are available for purchase in local markets for human consumption in several islands of the region. We examined the prevalence of ciguatoxins (CTXs) in lionfish from the French Antilles, a ciguatera-endemic region. The neuroblastoma-2a (N2a) cell assay was used to assess composite cytotoxicity in 120 fish samples collected from the surrounding waters of Guadeloupe (n = 60), Saint Barthélemy Islands (n = 55) and Saint Martin (n = 5). Twenty-seven of these samples exhibited CTX-like activity by the N2a assay. Ciguatoxin (CTX) was confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in multiple samples that presented highest composite toxicity levels by N2a. Those fish found to contain CTXs were all from Saint Barthélemy. Lionfish from Guadeloupe and Saint Martin did not exhibit toxin activity, although the sample size from Saint Martin was insufficient to draw any conclusions as to the incidence of CTXs. In this study, we provide information about the potential hazard of ciguatera associated with the consumption of lionfish from known endemic areas. We also demonstrate the utility of the cell-based assay combined with LC-MS/MS to assess activity and to provide structural confirmation of CTXs respectively. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Toxicon : official journal of the International Society on Toxinology AU - Soliño, Lucía AU - Widgy, Saha AU - Pautonnier, Anthony AU - Turquet, Jean AU - Loeffler, Christopher R AU - Flores Quintana, Harold A AU - Diogène, Jorge AD - Institut de la Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou Km 5,5, Sant Carles de la Ràpita, E-43540, Spain. ; Comité Régional des Pêches Maritimes et des Élevages Marins (CRPMEM), Rue Schoelcher 2 bis, Pointe a Pitre, 97110, Guadeloupe. ; Association Réunionnaise pour le Développement de 'Aquaculture (ARDA) et ARVAM, C/o CIROY, 2, Rue Maxime Rivière, 97490, Sainte Clotilde, Reunion. ; U.S. Food and Drug Administration (FDA), Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL, 36528, USA. ; Institut de la Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou Km 5,5, Sant Carles de la Ràpita, E-43540, Spain. Electronic address: jorge.diogene@irta.cat. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 62 EP - 68 VL - 102 KW - Marine Toxins KW - 0 KW - Ciguatoxins KW - 11050-21-8 KW - Index Medicus KW - Lionfish KW - Guadeloupe KW - Pterois spp. KW - Caribbean KW - Ciguatoxin KW - Ciguatera KW - Guadeloupe -- epidemiology KW - Animals KW - Caribbean Region -- epidemiology KW - Humans KW - Incidence KW - West Indies -- epidemiology KW - Prevalence KW - Marine Toxins -- analysis KW - Ciguatoxins -- toxicity KW - Ciguatera Poisoning -- epidemiology KW - Food Contamination -- analysis KW - Perciformes KW - Ciguatoxins -- analysis KW - Marine Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1695757075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Prevalence+of+ciguatoxins+in+lionfish+%28Pterois+spp.%29+from+Guadeloupe%2C+Saint+Martin%2C+and+Saint+Barth%C3%A9lmy+Islands+%28Caribbean%29.&rft.au=Soli%C3%B1o%2C+Luc%C3%ADa%3BWidgy%2C+Saha%3BPautonnier%2C+Anthony%3BTurquet%2C+Jean%3BLoeffler%2C+Christopher+R%3BFlores+Quintana%2C+Harold+A%3BDiog%C3%A8ne%2C+Jorge&rft.aulast=Soli%C3%B1o&rft.aufirst=Luc%C3%ADa&rft.date=2015-08-01&rft.volume=102&rft.issue=&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=1879-3150&rft_id=info:doi/10.1016%2Fj.toxicon.2015.05.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-07 N1 - Date created - 2015-07-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxicon.2015.05.015 ER - TY - JOUR T1 - Candidate HLA genes for prediction of co-trimoxazole-induced severe cutaneous reactions. AN - 1695756816; 26086150 AB - Co-trimoxazole is a sulfonamide-containing antibiotic that is effective in the treatment of several infections and for prophylaxis of Pneumocystis jiroveci pneumonia. This drug has been reported as a common culprit drug for the Stevens-Johnson syndrome (SJS) and for toxic epidermal necrolysis (TEN). Human leukocyte antigens (HLAs) play a key role in the immunopathogenesis of severe cutaneous reactions induced by several drugs. This study investigated the association between the HLA class I and HLA-DRB1 polymorphisms and co-trimoxazole-induced SJS/TEN in a Thai population. Forty-three patients with co-trimoxazole-induced SJS/TEN and 91 co-trimoxazole-tolerant patients were enrolled in the study. HLA class I and HLA-DRB1 were genotyped using the reverse sequence-specific oligonucleotide probe method. The frequencies of three alleles of HLA, namely HLA-B*15:02, HLA-C*06:02, and HLA-C*08:01, were significantly higher in the co-trimoxazole-induced SJS/TEN group compared with controls. The risks for co-trimoxazole-induced SJS/TEN in patients with the HLA-B*15:02, HLA-C*06:02, or HLA-C*08:01 allele were about 3-11-fold higher when compared with those who did not carry one of these alleles. Individuals who carried the HLA-B*15:02-C*08:01 haplotype had a 14-fold higher risk for co-trimoxazole-induced SJS/TEN. Evidence of associations between co-trimoxazole-induced SJS/TEN and HLA alleles including HLA-B*15:02, HLA-C*06:02, and HLA-C*08:01 were found in the study population. These findings may suggest that apart from the HLA molecules, other molecules involved in the molecular pathogenesis of these severe cutaneous adverse drug reactions may play an important role in the susceptibility of individuals to SJS/TEN caused by co-trimoxazole. JF - Pharmacogenetics and genomics AU - Kongpan, Thachanan AU - Mahasirimongkol, Surakameth AU - Konyoung, Parinya AU - Kanjanawart, Sirimas AU - Chumworathayi, Pansu AU - Wichukchinda, Nuanjun AU - Kidkeukarun, Runglak AU - Preechakul, Suphanlinee AU - Khunarkornsiri, Usanee AU - Bamrungram, Warawut AU - Supharatwattanakun, Butsaban AU - Mootsikapun, Piroon AU - Kwangsukstid, Supanida AU - Denjanta, Sukanda AU - Vannaprasaht, Suda AU - Rungapiromnan, Watcharee AU - Suwankesawong, Wimon AU - Tassaneeyakul, Wongwiwat AU - Tassaneeyakul, Wichittra AD - aDepartment of Pharmacology bPharmacy Unit cDepartment of Medicine, Faculty of Medicine dFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen eMedical Genetics Center, Medical Life Science Institute, Department of Medical Sciences, Ministry of Public Health fHealth Product Vigilance Center, Food and Drug Administration, Ministry of Public Health, Nonthaburi gPharmacy Unit hDepartment of Medicine, Udon Thani Hospital, Udon Thani iBuddhachinaraj Hospital, Phitsanulok jLampang Hospital, Lampang kRayong Hospital, Rayong lSongkhla Hospital, Songkhla mChiangraiprachanukroh Hospital, Chiangrai, Thailand. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 402 EP - 411 VL - 25 IS - 8 KW - HLA Antigens KW - 0 KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Index Medicus KW - Demography KW - Alleles KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - HLA Antigens -- genetics KW - Genetic Association Studies KW - Stevens-Johnson Syndrome -- genetics KW - Genetic Predisposition to Disease KW - Trimethoprim, Sulfamethoxazole Drug Combination -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1695756816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Candidate+HLA+genes+for+prediction+of+co-trimoxazole-induced+severe+cutaneous+reactions.&rft.au=Kongpan%2C+Thachanan%3BMahasirimongkol%2C+Surakameth%3BKonyoung%2C+Parinya%3BKanjanawart%2C+Sirimas%3BChumworathayi%2C+Pansu%3BWichukchinda%2C+Nuanjun%3BKidkeukarun%2C+Runglak%3BPreechakul%2C+Suphanlinee%3BKhunarkornsiri%2C+Usanee%3BBamrungram%2C+Warawut%3BSupharatwattanakun%2C+Butsaban%3BMootsikapun%2C+Piroon%3BKwangsukstid%2C+Supanida%3BDenjanta%2C+Sukanda%3BVannaprasaht%2C+Suda%3BRungapiromnan%2C+Watcharee%3BSuwankesawong%2C+Wimon%3BTassaneeyakul%2C+Wongwiwat%3BTassaneeyakul%2C+Wichittra&rft.aulast=Kongpan&rft.aufirst=Thachanan&rft.date=2015-08-01&rft.volume=25&rft.issue=8&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=1744-6880&rft_id=info:doi/10.1097%2FFPC.0000000000000153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-11 N1 - Date created - 2015-07-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/FPC.0000000000000153 ER - TY - JOUR T1 - Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles. AN - 1683357323; 25968464 AB - Sepsis is a life threatening disease that is associated with high mortality. Existing treatments have failed to improve survivability in septic patients. The purpose of this present study is to evaluate whether cerium oxide nanoparticles (CeO2NPs) can prevent lipopolysaccharide (LPS) induced severe sepsis mortality by preventing hepatic dysfunction in male Sprague Dawley rats. Administration of a single dose (0.5 mg/kg) of CeO2NPs intravenously to septic rats significantly improved survival rates and functioned to restore body temperature, respiratory rate and blood pressure towards baseline. Treatment-induced increases in animal survivability were associated with decreased hepatic damage along with reductions in serum cytokines/chemokines, and diminished inflammatory related signaling. Kupffer cells and macrophage cells exposed to CeO2NPs exhibited decreases in LPS-induced cytokine release (TNF-α, IL-1β, IL-6, HMGB1) which were associated with diminished cellular ROS, reduced levels of nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), and decreased nuclear factor-kappa light chain enhancer of activated B cells (NF-kB) transcriptional activity. The findings of this study indicate that CeO2NPs may be useful as a therapeutic agent for sepsis. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Biomaterials AU - Selvaraj, Vellaisamy AU - Nepal, Niraj AU - Rogers, Steven AU - Manne, Nandini D P K AU - Arvapalli, Ravikumar AU - Rice, Kevin M AU - Asano, Shinichi AU - Fankhanel, Erin AU - Ma, Jane J AU - Shokuhfar, Tolou AU - Maheshwari, Mani AU - Blough, Eric R AD - Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA. ; Health Effects Laboratory Division, NIOSH, Morgantown, WV, USA. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, USA. ; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA; Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA; Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, USA. Electronic address: blough@marshall.edu. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 160 EP - 171 VL - 59 KW - Lipopolysaccharides KW - 0 KW - NF-kappa B KW - Cerium KW - 30K4522N6T KW - ceric oxide KW - 619G5K328Y KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Sepsis KW - Macrophage KW - Cytokines KW - Lipopolysaccharide KW - Cerium oxide nanoparticles KW - Rats KW - Microscopy, Electron, Transmission KW - Animals KW - Microscopy, Electron, Scanning KW - Sepsis -- chemically induced KW - Metal Nanoparticles -- chemistry KW - Mitogen-Activated Protein Kinases -- metabolism KW - Cerium -- therapeutic use KW - Sepsis -- drug therapy KW - Lipopolysaccharides -- toxicity KW - Metal Nanoparticles -- therapeutic use KW - Signal Transduction KW - NF-kappa B -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683357323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Inhibition+of+MAP+kinase%2FNF-kB+mediated+signaling+and+attenuation+of+lipopolysaccharide+induced+severe+sepsis+by+cerium+oxide+nanoparticles.&rft.au=Selvaraj%2C+Vellaisamy%3BNepal%2C+Niraj%3BRogers%2C+Steven%3BManne%2C+Nandini+D+P+K%3BArvapalli%2C+Ravikumar%3BRice%2C+Kevin+M%3BAsano%2C+Shinichi%3BFankhanel%2C+Erin%3BMa%2C+Jane+J%3BShokuhfar%2C+Tolou%3BMaheshwari%2C+Mani%3BBlough%2C+Eric+R&rft.aulast=Selvaraj&rft.aufirst=Vellaisamy&rft.date=2015-08-01&rft.volume=59&rft.issue=&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=1878-5905&rft_id=info:doi/10.1016%2Fj.biomaterials.2015.04.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-26 N1 - Date created - 2015-05-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cytokine. 2005 Feb 21;29(4):169-75 [15652449] J Immunol. 2004 Dec 1;173(11):6973-80 [15557194] J Surg Res. 2005 Nov;129(1):114-21 [16243048] FASEB J. 2005 Nov;19(13):1822-35 [16260652] J Endocrinol. 2006 Mar;188(3):503-11 [16522730] World J Gastroenterol. 2006 Dec 14;12(46):7413-20 [17167827] Cardiovasc Res. 2007 Feb 1;73(3):549-59 [17207782] Biochem Pharmacol. 2007 Mar 15;73(6):793-804 [17182007] Circulation. 2007 Aug 14;116(7):793-802 [17698745] Biomaterials. 2007 Nov;28(31):4600-7 [17675227] Nanomedicine (Lond). 2007 Jun;2(3):325-32 [17716177] Mitochondrion. 2008 Jun;8(3):211-8 [18417427] Small. 2009 Dec;5(24):2848-56 [19802857] J Clin Invest. 2011 Jan;121(1):308-17 [21183794] Nanoscale. 2011 Apr;3(4):1411-20 [21369578] J Physiol. 2011 May 1;589(Pt 9):2129-38 [21224240] J Pharmacol Exp Ther. 2011 Jul;338(1):53-61 [21464334] Int J Nanomedicine. 2011;6:2327-35 [22072870] Eur J Nutr. 2011 Dec;50(8):673-80 [21373948] Liver Int. 2012 Jan;32(1):8-20 [21745276] Biochim Biophys Acta. 2012 May;1822(5):714-28 [22101076] Mol Med. 2012;18:455-65 [22252713] Chemosphere. 2013 Jan;90(3):1201-9 [23121984] Environ Toxicol. 2013 Feb;28(2):107-18 [21618676] PLoS One. 2013;8(8):e70832 [23967115] Biomaterials. 2014 Jan;35(1):249-58 [24140045] Exp Eye Res. 2013 Nov;116:63-74 [23978600] Toxicol Pathol. 2014 Aug;42(6):984-96 [24178579] Lancet. 2005 Jan 1-7;365(9453):63-78 [15639681] J R Coll Surg Edinb. 2000 Jun;45(3):178-82 [10881485] Crit Care Med. 2001 Jul;29(7):1303-10 [11445675] Inflammation. 2002 Jun;26(3):129-37 [12083419] Chest. 1992 Jun;101(6):1644-55 [1303622] Eur J Pharmacol. 1995 Mar 16;292(3-4):341-4 [7796876] Cancer Res. 1998 Feb 15;58(4):717-23 [9485026] Biochemistry (Mosc). 1998 Jul;63(7):826-32 [9721335] Fish Shellfish Immunol. 2005 Oct;19(4):293-306 [15863011] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.biomaterials.2015.04.025 ER - TY - RPRT T1 - NATIONAL INSTITUTES OF HEALTH BETHESDA CHILLED WATER SYSTEM IMPROVEMENTS, MONTGOMERY COUNTY, BETHESDA, MARYLAND. AN - 16382572; 16580 AB - PURPOSE: The National Institutes of Health (NIH) is contemplating implementation of chilled water system improvements at the NIH Bethesda Campus. The need for the chilled water system improvements is to prevent a disruption in the chilled water supply which would result in severe consequences on patient care, animal welfare, and biomedical research. Improvements are needed to address real deficiencies within the campus water systems. Three alternatives were considered in detail in the Draft Environmental Impact Statement. The Proposed Action would install a Thermal Energy Storage System and an Industrial Water Storage System to provide sufficient storage capacity to meet two days of chilled water demand and two days of industrial water demand should an outside disturbance interrupt the water supply. The Alternative Action would install a Thermal Energy Storage System and a Potable Water Storage System to provide sufficient storage capacity to meet two days of chilled water demand and two days of potable water demand. The No-Action Alternative would continue current NIH operations and would not implement chilled water system improvements. The NIH's preferred alternative is the Proposed Action alternative. JF - EPA number: 150203, Final EIS, July 31, 2015 Y1 - 2015/07/31/ PY - 2015 DA - 2015 Jul 31 KW - Water KW - Water Storage KW - Water Supply KW - Industrial Water KW - Water Resources KW - Wetlands KW - Floodplains KW - Traffic Analyses KW - Noise KW - Air Quality KW - Vegetation KW - Archaeological Sites KW - Socioeconomic Assessments KW - Emissions KW - Historic Sites KW - Waste Management KW - Maryland KW - Clean Air Act Amendments of 1990, Emission Standards KW - Resources Conservation and Recovery Act, Compliance KW - National Historic Preservation Act of 1966, Historic Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16382572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2015-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CHILLED+WATER+SYSTEM+IMPROVEMENTS%2C+MONTGOMERY+COUNTY%2C+BETHESDA%2C+MARYLAND.&rft.title=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CHILLED+WATER+SYSTEM+IMPROVEMENTS%2C+MONTGOMERY+COUNTY%2C+BETHESDA%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland N1 - Date revised - 2017-02-01 N1 - SuppNotes - Final. Preparation date: July 31, 2015 N1 - Last updated - 2017-02-06 ER - TY - JOUR T1 - Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis AN - 1808632960; PQ0003435541 AB - ObjectiveDiazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk. We used updated diazinon exposure and cancer incidence information to evaluate solid tumour risk in the AHS.MethodsMale pesticide applicators in Iowa and North Carolina reported lifetime diazinon use at enrolment (1993-1997) and follow-up (1998-2005); cancer incidence was assessed through 2010(North Carolina)/2011(Iowa). Among applicators with usage information sufficient to evaluate exposure-response patterns, we used Poisson regression to estimate adjusted rate ratios (RRs) and 95% CI for cancer sites with greater than or equal to 10 exposed cases for both lifetime (LT) exposure days and intensity-weighted (IW) lifetime exposure days (accounting for factors impacting exposure).ResultsWe observed elevated lung cancer risks (N=283) among applicators with the greatest number of LT (RR=1.60; 95% CI 1.11 to 2.31; Ptrend=0.02) and IW days of diazinon use (RR=1.41; 95% CI 0.98 to 2.04; Ptrend=0.08). Kidney cancer (N=94) risks were non-significantly elevated (RRLT days=1.77; 95% CI 0.90 to 3.51; Ptrend=0.09; RRIW days 1.37; 95% CI 0.64 to 2.92; Ptrend=0.50), as were risks for aggressive prostate cancer (N=656).ConclusionsOur updated evaluation of diazinon provides additional evidence of an association with lung cancer risk. Newly identified links to kidney cancer and associations with aggressive prostate cancer require further evaluation. JF - Occupational and Environmental Medicine AU - Jones, Rena R AU - Barone-Adesi, Francesco AU - Koutros, Stella AU - Lerro, Catherine C AU - Blair, Aaron AU - Lubin, Jay AU - Heltshe, Sonya L AU - Hoppin, Jane A AU - Alavanja, Michael C R AU - Beane Freeman, Laura E AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2015/07/23/ PY - 2015 DA - 2015 Jul 23 SP - 496 EP - 503 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 72 IS - 7 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - diazinon KW - insecticides KW - organophosphate KW - neoplasms KW - Risk assessment KW - ANW, USA, North Carolina KW - Organophosphates KW - Genotoxicity KW - Cancer KW - Health risks KW - Insecticides KW - Prostate cancer KW - USA, Iowa KW - Dose-response effects KW - Risk factors KW - Pesticides KW - Kidney KW - Diazinon KW - Lung cancer KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808632960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Incidence+of+solid+tumours+among+pesticide+applicators+exposed+to+the+organophosphate+insecticide+diazinon+in+the+Agricultural+Health+Study%3A+an+updated+analysis&rft.au=Jones%2C+Rena+R%3BBarone-Adesi%2C+Francesco%3BKoutros%2C+Stella%3BLerro%2C+Catherine+C%3BBlair%2C+Aaron%3BLubin%2C+Jay%3BHeltshe%2C+Sonya+L%3BHoppin%2C+Jane+A%3BAlavanja%2C+Michael+C+R%3BBeane+Freeman%2C+Laura+E&rft.aulast=Jones&rft.aufirst=Rena&rft.date=2015-07-23&rft.volume=72&rft.issue=7&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102728 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Organophosphates; Genotoxicity; Cancer; Health risks; Prostate cancer; Insecticides; Risk factors; Dose-response effects; Pesticides; Kidney; Diazinon; Lung cancer; ANW, USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1136/oemed-2014-102728 ER - TY - JOUR T1 - Performance of genetic risk factors in prediction of trichloroethylene induced hypersensitivity syndrome. AN - 1698962336; 26190474 AB - Trichloroethylene induced hypersensitivity syndrome is dose-independent and potentially life threatening disease, which has become one of the serious occupational health issues and requires intensive treatment. To discover the genetic risk factors and evaluate the performance of risk prediction model for the disease, we conducted genomewide association study and replication study with total of 174 cases and 1761 trichloroethylene-tolerant controls. Fifty seven SNPs that exceeded the threshold for genome-wide significance (P < 5 × 10(-8)) were screened to relate with the disease, among which two independent SNPs were identified, that is rs2857281 at MICA (odds ratio, 11.92; P meta = 1.33 × 10(-37)) and rs2523557 between HLA-B and MICA (odds ratio, 7.33; P meta = 8.79 × 10(-35)). The genetic risk score with these two SNPs explains at least 20.9% of the disease variance and up to 32.5-fold variation in inter-individual risk. Combining of two SNPs as predictors for the disease would have accuracy of 80.73%, the area under receiver operator characteristic curves (AUC) scores was 0.82 with sensitivity of 74% and specificity of 85%, which was considered to have excellent discrimination for the disease, and could be considered for translational application for screening employees before exposure. JF - Scientific reports AU - Dai, Yufei AU - Chen, Ying AU - Huang, Hanlin AU - Zhou, Wei AU - Niu, Yong AU - Zhang, Mingrong AU - Bin, Ping AU - Dong, Haiyan AU - Jia, Qiang AU - Huang, Jianxun AU - Yi, Juan AU - Liao, Qijun AU - Li, Haishan AU - Teng, Yanxia AU - Zang, Dan AU - Zhai, Qingfeng AU - Duan, Huawei AU - Shen, Juan AU - He, Jiaxi AU - Meng, Tao AU - Sha, Yan AU - Shen, Meili AU - Ye, Meng AU - Jia, Xiaowei AU - Xiang, Yingping AU - Huang, Huiping AU - Wu, Qifeng AU - Shi, Mingming AU - Huang, Xianqing AU - Yang, Huanming AU - Luo, Longhai AU - Li, Sai AU - Li, Lin AU - Zhao, Jinyang AU - Li, Laiyu AU - Wang, Jun AU - Zheng, Yuxin AD - Key laboratory of Chemical Safety and Health, Chinese Centre for Disease Control and Prevention. National Institute for Occupational Health and Poison Control, Chinese Centre for Disease Control and Prevention, Beijing, 100050, China. ; BGI-Tech, BGI-Shenzhen, Shenzhen, China. ; Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, China. ; Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, China. ; Center for Disease Control and Prevention of Yunnan province, Kunming, Yunnan, China. ; Shandong Academy of Occupational Health and Occupational Medicine, Jinan, China. ; Institute of chemicals safety, Chinese academy of inspection and quarantine, Beijing, China. ; Health Supervision Institutionof Dongcheng Health Bureau, Beijing, China. ; Food And Drug Administration Of Beijing Fengtai District, Beijing, China. ; Weifang Medical University, Weifang, Shandong, China. Y1 - 2015/07/20/ PY - 2015 DA - 2015 Jul 20 SP - 12169 VL - 5 KW - Anesthetics, Inhalation KW - 0 KW - Histocompatibility Antigens KW - Trichloroethylene KW - 290YE8AR51 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - ROC Curve KW - Risk Factors KW - Humans KW - Prognosis KW - Case-Control Studies KW - Histocompatibility Antigens -- genetics KW - Genome-Wide Association Study KW - Anesthetics, Inhalation -- adverse effects KW - Drug Hypersensitivity Syndrome -- etiology KW - Trichloroethylene -- adverse effects KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698962336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Performance+of+genetic+risk+factors+in+prediction+of+trichloroethylene+induced+hypersensitivity+syndrome.&rft.au=Dai%2C+Yufei%3BChen%2C+Ying%3BHuang%2C+Hanlin%3BZhou%2C+Wei%3BNiu%2C+Yong%3BZhang%2C+Mingrong%3BBin%2C+Ping%3BDong%2C+Haiyan%3BJia%2C+Qiang%3BHuang%2C+Jianxun%3BYi%2C+Juan%3BLiao%2C+Qijun%3BLi%2C+Haishan%3BTeng%2C+Yanxia%3BZang%2C+Dan%3BZhai%2C+Qingfeng%3BDuan%2C+Huawei%3BShen%2C+Juan%3BHe%2C+Jiaxi%3BMeng%2C+Tao%3BSha%2C+Yan%3BShen%2C+Meili%3BYe%2C+Meng%3BJia%2C+Xiaowei%3BXiang%2C+Yingping%3BHuang%2C+Huiping%3BWu%2C+Qifeng%3BShi%2C+Mingming%3BHuang%2C+Xianqing%3BYang%2C+Huanming%3BLuo%2C+Longhai%3BLi%2C+Sai%3BLi%2C+Lin%3BZhao%2C+Jinyang%3BLi%2C+Laiyu%3BWang%2C+Jun%3BZheng%2C+Yuxin&rft.aulast=Dai&rft.aufirst=Yufei&rft.date=2015-07-20&rft.volume=5&rft.issue=&rft.spage=12169&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep12169 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-03 N1 - Date created - 2015-07-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Transplant. 2009 Feb;9(2):251-7 [19178412] Crit Rev Toxicol. 2000 May;30(3):253-85 [10852497] Environ Health Perspect. 2009 May;117(5):696-702 [19479009] Exp Clin Immunogenet. 2000;17(3):130-7 [10899738] Tissue Antigens. 2000 Dec;56(6):548-50 [11169245] Nat Immunol. 2001 Mar;2(3):255-60 [11224526] J Occup Health. 2003 Jan;45(1):8-14 [14605423] Radiology. 1982 Apr;143(1):29-36 [7063747] Science. 1988 Jun 3;240(4857):1285-93 [3287615] Crit Rev Toxicol. 1989;20(1):31-50 [2673291] Arthritis Rheum. 1998 Jan;41(1):68-73 [9433871] Invest Ophthalmol Vis Sci. 1999 Aug;40(9):1921-6 [10440244] Biomarkers. 2004 Nov-Dec;9(6):470-8 [15849067] Occup Environ Med. 2005 Sep;62(9):657-62, 597 [16109824] J Occup Health. 2006 Nov;48(6):417-23 [17179634] Toxicol Sci. 2007 Feb;95(2):401-11 [17077186] Int Arch Occup Environ Health. 2007 Apr;80(5):357-70 [17106739] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] Environ Health Perspect. 2007 Nov;115(11):1553-6 [18007983] Trends Immunol. 2008 Aug;29(8):397-403 [18602338] J Occup Health. 2008;50(4):328-38 [18540116] PLoS Genet. 2009 Oct;5(10):e1000678 [19816555] Ind Health. 2009 Oct;47(5):479-86 [19834256] Tissue Antigens. 2010 Jan;75(1):48-55 [19895570] Nat Rev Genet. 2010 Jun;11(6):446-50 [20479774] Dermatology. 2010 Aug;221(1):17-22 [20407216] J Dermatol. 2011 Mar;38(3):229-35 [21342224] Endocr J. 2011;58(9):723-39 [21778616] Arthritis Res Ther. 2011;13(1):101 [21345260] Nature. 2012 Nov 1;491(7422):56-65 [23128226] Lancet Oncol. 2012 Dec;13(12):1192-3 [23323277] Allergol Int. 2013 Mar;62(1):21-8 [23439055] Nat Rev Genet. 2013 Jul;14(7):507-15 [23774735] J Dermatol Sci. 2013 Dec;72(3):218-24 [23928230] Eur J Hum Genet. 2014 Mar;22(3):402-8 [23881057] Brief Funct Genomics. 2014 Sep;13(5):384-91 [24771349] Curr Diab Rep. 2009 Apr;9(2):157-63 [19323961] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep12169 ER - TY - JOUR T1 - Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases. AN - 1696681187; 26168713 AB - With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism that circumvents existing resistance. ETX0914, the first of a new class of antibacterial agent targeted for the treatment of gonorrhea, operates by a novel mode-of-inhibition against bacterial type II topoisomerases. Incorporating an oxazolidinone on the scaffold mitigated toxicological issues often seen with topoisomerase inhibitors. Organisms resistant to other topoisomerase inhibitors were not cross-resistant with ETX0914 nor were spontaneous resistant mutants to ETX0914 cross-resistant with other topoisomerase inhibitor classes, including the widely used fluoroquinolone class. Preclinical evaluation of ETX0914 pharmacokinetics and pharmacodynamics showed distribution into vascular tissues and efficacy in a murine Staphylococcus aureus infection model that served as a surrogate for predicting efficacious exposures for the treatment of Neisseria gonorrhoeae infections. A wide safety margin to the efficacious exposure in toxicological evaluations supported progression to Phase 1. Dosing ETX0914 in human volunteers showed sufficient exposure and minimal adverse effects to expect a highly efficacious anti-gonorrhea therapy. JF - Scientific reports AU - Basarab, Gregory S AU - Kern, Gunther H AU - McNulty, John AU - Mueller, John P AU - Lawrence, Kenneth AU - Vishwanathan, Karthick AU - Alm, Richard A AU - Barvian, Kevin AU - Doig, Peter AU - Galullo, Vincent AU - Gardner, Humphrey AU - Gowravaram, Madhusudhan AU - Huband, Michael AU - Kimzey, Amy AU - Morningstar, Marshall AU - Kutschke, Amy AU - Lahiri, Sushmita D AU - Perros, Manos AU - Singh, Renu AU - Schuck, Virna J A AU - Tommasi, Ruben AU - Walkup, Grant AU - Newman, Joseph V AD - Department of Chemistry, Drug Discovery and Development Center, University of Cape Town, Rondebosch 7701, South Africa. ; AstraZeneca R&D Boston, Infection iMed, 35 Gatehouse Dr. Waltham, MA 02415 USA. ; Shire Pharmaceuticals, 300 Shire Way, Lexington, MA 02421. ; Entasis Therapeutics, 35 Gatehouse Drive Suite E0, Waltham, MA 02415 USA. ; Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203. ; Center for Drug Evaluation and Research, U.S. FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993. ; JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. ; Broad Institute, 415 Main St., Cambridge, MA 02142. ; Norvartis Pharmaceutical Corporation, Bldg. 335, Office 3104B, One Health Plaza, East Hanover, NJ 07936-1080. Y1 - 2015/07/14/ PY - 2015 DA - 2015 Jul 14 SP - 11827 VL - 5 KW - AZD0914 KW - 0 KW - Anti-Bacterial Agents KW - Barbiturates KW - Fluoroquinolones KW - Spiro Compounds KW - Topoisomerase II Inhibitors KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - Index Medicus KW - Young Adult KW - Animals KW - Drug Resistance, Bacterial KW - Humans KW - Disease Models, Animal KW - Rats KW - Staphylococcal Infections -- drug therapy KW - Adult KW - Neisseria gonorrhoeae -- genetics KW - Microbial Sensitivity Tests KW - Male KW - DNA Topoisomerases, Type II -- chemistry KW - Dose-Response Relationship, Drug KW - Models, Molecular KW - Mice KW - Staphylococcal Infections -- microbiology KW - Staphylococcus aureus -- drug effects KW - Haplorhini KW - Neisseria gonorrhoeae -- drug effects KW - Dogs KW - Fluoroquinolones -- pharmacology KW - Middle Aged KW - Molecular Conformation KW - Mutation KW - Female KW - Anti-Bacterial Agents -- therapeutic use KW - Spiro Compounds -- chemistry KW - Barbiturates -- pharmacology KW - Barbiturates -- therapeutic use KW - Anti-Bacterial Agents -- pharmacology KW - Gonorrhea -- microbiology KW - Topoisomerase II Inhibitors -- chemistry KW - Topoisomerase II Inhibitors -- pharmacology KW - Barbiturates -- chemistry KW - Spiro Compounds -- pharmacology KW - Topoisomerase II Inhibitors -- therapeutic use KW - Anti-Bacterial Agents -- chemistry KW - Gonorrhea -- drug therapy KW - Spiro Compounds -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1696681187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Responding+to+the+challenge+of+untreatable+gonorrhea%3A+ETX0914%2C+a+first-in-class+agent+with+a+distinct+mechanism-of-action+against+bacterial+Type+II+topoisomerases.&rft.au=Basarab%2C+Gregory+S%3BKern%2C+Gunther+H%3BMcNulty%2C+John%3BMueller%2C+John+P%3BLawrence%2C+Kenneth%3BVishwanathan%2C+Karthick%3BAlm%2C+Richard+A%3BBarvian%2C+Kevin%3BDoig%2C+Peter%3BGalullo%2C+Vincent%3BGardner%2C+Humphrey%3BGowravaram%2C+Madhusudhan%3BHuband%2C+Michael%3BKimzey%2C+Amy%3BMorningstar%2C+Marshall%3BKutschke%2C+Amy%3BLahiri%2C+Sushmita+D%3BPerros%2C+Manos%3BSingh%2C+Renu%3BSchuck%2C+Virna+J+A%3BTommasi%2C+Ruben%3BWalkup%2C+Grant%3BNewman%2C+Joseph+V&rft.aulast=Basarab&rft.aufirst=Gregory&rft.date=2015-07-14&rft.volume=5&rft.issue=&rft.spage=11827&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep11827 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-10 N1 - Date created - 2015-07-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2004 Oct;32(10):1092-5 [15217988] Antimicrob Agents Chemother. 2002 Jun;46(6):1665-70 [12019073] Sex Transm Infect. 2013 Dec;89 Suppl 4:iv5-10 [24243881] Clin Infect Dis. 2014 Jan;58 Suppl 1:S20-7 [24343828] J Med Chem. 2013 Nov 14;56(21):8712-35 [24098982] Chem Rev. 2014 Feb 26;114(4):2313-42 [24313284] Biochemistry. 2014 Mar 18;53(10):1565-74 [24576155] Expert Rev Anti Infect Ther. 2014 Jun;12(6):653-6 [24702589] J Clin Microbiol. 2014 Jul;52(7):2629-32 [24759716] Antimicrob Agents Chemother. 2002 Nov;46(11):3484-9 [12384354] Drugs. 2003;63(24):2769-802 [14664657] Clin Pharmacokinet. 2003;42(15):1411-23 [14674791] Pacing Clin Electrophysiol. 2003 Dec;26(12):2317-20 [14675020] Expert Opin Drug Saf. 2004 Sep;3(5):405-14 [15335296] J Antimicrob Chemother. 2014 Aug;69(8):2086-90 [24777907] Clin Pharmacol Ther. 2014 Aug;96(2):151-3 [25056396] Antimicrob Agents Chemother. 1987 Jul;31(7):1054-60 [3116917] Xenobiotica. 1987 Oct;17(10):1139-45 [3424863] J Infect Dis. 1989 Feb;159(2):281-92 [2644371] Antimicrob Agents Chemother. 1991 Aug;35(8):1647-50 [1656869] Antimicrob Agents Chemother. 1993 May;37(5):1073-81 [8517694] Antimicrob Agents Chemother. 1993 Sep;37(9):2007-8 [8239622] Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):89-96 [7587056] Clin Infect Dis. 1998 Jan;26(1):1-10; quiz 11-2 [9455502] Clin Microbiol Infect. 2005 Apr;11(4):256-80 [15760423] Med Clin North Am. 2006 Nov;90(6):1165-82 [17116442] Int J Antimicrob Agents. 2007 Apr;29(4):374-9 [17241772] J Infect Dis. 2007 Jun 15;195(12):1818-27 [17492598] Antimicrob Agents Chemother. 2008 Aug;52(8):2806-12 [18519725] Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49 [18625781] Nucleic Acids Res. 2008 Oct;36(17):5516-29 [18723572] J Am Chem Soc. 2009 Mar 25;131(11):3991-7 [19260642] J Med Microbiol. 2009 May;58(Pt 5):683-7 [19369534] N Engl J Med. 2009 Jun 4;360(23):2397-405 [19494215] Antimicrob Agents Chemother. 2009 Aug;53(8):3331-6 [19433553] Intern Med J. 2009 Sep;39(9):619-23 [19769684] J Med Chem. 2009 Nov 12;52(21):6752-6 [19827778] Ann N Y Acad Sci. 2011 Aug;1230:E19-28 [22239555] N Engl J Med. 2012 Feb 9;366(6):485-7 [22316442] J Med Chem. 2012 Aug 9;55(15):6916-33 [22779424] Biochem Pharmacol. 2012 Oct 1;84(7):900-4 [22820247] Nucleic Acids Res. 2013 Apr;41(8):4628-39 [23460203] Curr Drug Saf. 2014;9(2):89-105 [24410307] J Med Chem. 2014 Nov 13;57(21):9078-95 [25286019] Org Lett. 2014 Dec 19;16(24):6456-9 [25458849] ACS Chem Biol. 2014 Dec 19;9(12):2895-904 [25310082] Antimicrob Agents Chemother. 2015 Jan;59(1):467-74 [25385112] Antimicrob Agents Chemother. 2015 Mar;59(3):1478-86 [25534723] Antimicrob Agents Chemother. 2014 Sep;58(9):5585-8 [24982070] Drugs. 2000 Jan;59(1):7-16 [10718097] Antimicrob Agents Chemother. 2001 Oct;45(10):2755-64 [11557465] J Antimicrob Chemother. 2001 Oct;48(4):545-8 [11581235] Annu Rev Biochem. 2001;70:369-413 [11395412] Clin Infect Dis. 2002 Mar 1;34(5):695-8 [11803505] Erratum In: Sci Rep. 2015;5:14157 [26383116] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep11827 ER - TY - JOUR T1 - Effects of nitrogen-doped multi-walled carbon nanotubes compared to pristine multi-walled carbon nanotubes on human small airway epithelial cells. AN - 1688000050; 25797581 AB - Nitrogen-doped multi-walled carbon nanotubes (ND-MWCNTs) are modified multi-walled carbon nanotubes (MWCNTs) with enhanced electrical properties that are used in a variety of applications, including fuel cells and sensors; however, the mode of toxic action of ND-MWCNT has yet to be fully elucidated. In the present study, we compared the interaction of ND-MWCNT or pristine MWCNT-7 with human small airway epithelial cells (SAEC) and evaluated their subsequent bioactive effects. Transmission electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, and X-ray diffraction suggested the presence of N-containing defects in the lattice of the nanotube. The ND-MWCNTs were determined to be 93.3% carbon, 3.8% oxygen, and 2.9% nitrogen. A dose-response cell proliferation assay showed that low doses of ND-MWCNT (1.2μg/ml) or MWCNT-7 (0.12μg/ml) increased cellular proliferation, while the highest dose of 120μg/ml of either material decreased proliferation. ND-MWCNT and MWCNT-7 appeared to interact with SAEC at 6h and were internalized by 24h. ROS were elevated at 6 and 24h in ND-MWCNT exposed cells, but only at 6h in MWCNT-7 exposed cells. Significant alterations to the cell cycle were observed in SAEC exposed to either 1.2μg/ml of ND-MWCNT or MWCNT-7 in a time and material-dependent manner, possibly suggesting potential damage or alterations to cell cycle machinery. Our results indicate that ND-MWCNT induce effects in SAEC over a time and dose-related manner which differ from MWCNT-7. Therefore, the physicochemical characteristics of the materials appear to alter their biological effects. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Mihalchik, Amy L AU - Ding, Weiqiang AU - Porter, Dale W AU - McLoughlin, Colleen AU - Schwegler-Berry, Diane AU - Sisler, Jennifer D AU - Stefaniak, Aleksandr B AU - Snyder-Talkington, Brandi N AU - Cruz-Silva, Rodolfo AU - Terrones, Mauricio AU - Tsuruoka, Shuji AU - Endo, Morinobu AU - Castranova, Vincent AU - Qian, Yong AD - Pharmaceutical and Pharmacological Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, United States; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States. ; Shared Research Facilities, West Virginia University, Morgantown, WV 26505, United States. ; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States. ; Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States. ; Research Center for Exotic Nanocarbons, Shinshu University, Nagano, Japan. ; Research Center for Exotic Nanocarbons, Shinshu University, Nagano, Japan; Departments of Physics, Chemistry, Materials Science & Engineering, and Center for 2-Dimensional and Layered Materials, The Pennsylvania State University, University Park, PA 16802, United States. ; Pharmaceutical and Pharmacological Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, United States. ; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States. Electronic address: yaq2@cdc.gov. Y1 - 2015/07/03/ PY - 2015 DA - 2015 Jul 03 SP - 25 EP - 36 VL - 333 KW - Nanotubes, Carbon KW - 0 KW - Reactive Oxygen Species KW - Phosphothreonine KW - 1114-81-4 KW - Phosphotyrosine KW - 21820-51-9 KW - CDK4 protein, human KW - EC 2.7.11.22 KW - Cyclin-Dependent Kinase 4 KW - Nitrogen KW - N762921K75 KW - Index Medicus KW - Reactive oxygen species KW - Functionalized multi-walled carbon nanotubes KW - Multi-walled carbon nanotubes KW - Cell Proliferation -- drug effects KW - Reactive Oxygen Species -- metabolism KW - X-Ray Diffraction KW - Dose-Response Relationship, Drug KW - Humans KW - Phosphotyrosine -- metabolism KW - Spectrum Analysis, Raman KW - Risk Assessment KW - Phosphothreonine -- metabolism KW - Cyclin-Dependent Kinase 4 -- metabolism KW - Microscopy, Electron, Transmission KW - Photoelectron Spectroscopy KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Toxicity Tests -- methods KW - Time Factors KW - Cell Cycle -- drug effects KW - Microscopy, Electron, Scanning KW - Epithelial Cells -- ultrastructure KW - Epithelial Cells -- metabolism KW - Bronchioles -- metabolism KW - Bronchioles -- drug effects KW - Epithelial Cells -- drug effects KW - Nitrogen -- toxicity KW - Nitrogen -- metabolism KW - Nanotubes, Carbon -- toxicity KW - Bronchioles -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1688000050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Effects+of+nitrogen-doped+multi-walled+carbon+nanotubes+compared+to+pristine+multi-walled+carbon+nanotubes+on+human+small+airway+epithelial+cells.&rft.au=Mihalchik%2C+Amy+L%3BDing%2C+Weiqiang%3BPorter%2C+Dale+W%3BMcLoughlin%2C+Colleen%3BSchwegler-Berry%2C+Diane%3BSisler%2C+Jennifer+D%3BStefaniak%2C+Aleksandr+B%3BSnyder-Talkington%2C+Brandi+N%3BCruz-Silva%2C+Rodolfo%3BTerrones%2C+Mauricio%3BTsuruoka%2C+Shuji%3BEndo%2C+Morinobu%3BCastranova%2C+Vincent%3BQian%2C+Yong&rft.aulast=Mihalchik&rft.aufirst=Amy&rft.date=2015-07-03&rft.volume=333&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-17 N1 - Date created - 2015-06-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Carcinogenesis. 2005 Apr;26(4):725-31 [15677631] Nano Lett. 2005 Dec;5(12):2448-64 [16351195] Science. 2006 Feb 3;311(5761):622-7 [16456071] Nano Lett. 2006 Aug;6(8):1609-16 [16895344] Small. 2007 Oct;3(10):1723-9 [17849378] Inhal Toxicol. 2008 Jun;20(8):741-9 [18569096] Nat Nanotechnol. 2008 Jul;3(7):423-8 [18654567] Biochem Biophys Res Commun. 2009 Feb 6;379(2):643-8 [19121628] Biosens Bioelectron. 2009 Oct 15;25(2):373-7 [19683424] Toxicology. 2010 Mar 10;269(2-3):136-47 [19857541] J Toxicol Environ Health A. 2010;73(12):819-36 [20391123] Part Fibre Toxicol. 2010;7:28 [20920331] Toxicol Appl Pharmacol. 2010 Nov 15;249(1):8-15 [20800606] Toxicol Appl Pharmacol. 2011 Aug 15;255(1):18-31 [21624382] Part Fibre Toxicol. 2011;8:21 [21781304] Biomaterials. 2011 Oct;32(30):7677-86 [21764122] J Toxicol Environ Health A. 2012;75(2):112-28 [22129238] Chem Res Toxicol. 2011 Dec 19;24(12):2237-48 [22081859] Cell Signal. 2012 May;24(5):981-90 [22286106] Toxicol In Vitro. 2012 Aug;26(5):672-7 [22449549] Chem Res Toxicol. 2012 Jun 18;25(6):1212-21 [22428663] Gene. 2012 Dec 10;511(1):1-6 [22981713] J Toxicol Environ Health B Crit Rev. 2012;15(7):468-92 [23190270] ACS Nano. 2013 Mar 26;7(3):2352-68 [23414138] Toxicol Sci. 2013 May;133(1):79-89 [23377615] Curr Opin Biotechnol. 2013 Aug;24(4):724-34 [23768801] Part Fibre Toxicol. 2013;10:35 [23903001] Toxicol Appl Pharmacol. 2013 Oct 15;272(2):476-89 [23845593] Nanotoxicology. 2013 Nov;7(7):1179-94 [22881873] Part Fibre Toxicol. 2013;10:44 [24004820] Nanotoxicology. 2014 Aug;8(5):485-507 [23634900] Part Fibre Toxicol. 2014;11:6 [24479647] Bioorg Khim. 2013 Jul-Aug;39(4):383-99 [24707719] Biomaterials. 2014 Aug;35(24):6657-66 [24818879] Part Fibre Toxicol. 2013;10:33 [23895460] Free Radic Biol Med. 2014 Aug;73:84-94 [24824983] Nanotoxicology. 2015 May;9(4):413-22 [25030099] J Cell Sci. 2004 Mar 15;117(Pt 8):1281-3 [15020666] Gene. 2004 Aug 4;337:1-13 [15276197] Cell. 1995 Jan 27;80(2):179-85 [7834738] Cell. 1995 Jan 27;80(2):225-36 [7834742] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.03.008 ER - TY - JOUR T1 - Sodium nitrite potentiates renal oxidative stress and injury in hemoglobin exposed guinea pigs. AN - 1687999756; 25891524 AB - Methemoglobin-forming drugs, such as sodium nitrite (NaNO2), may exacerbate oxidative toxicity under certain chronic or acute hemolytic settings. In this study, we evaluated markers of renal oxidative stress and injury in guinea pigs exposed to extracellular hemoglobin (Hb) followed by NaNO2 at doses sufficient to simulate clinically relevant acute methemoglobinemia. NaNO2 induced rapid and extensive oxidation of plasma Hb in this model. This was accompanied by increased renal expression of the oxidative response effectors nuclear factor erythroid 2-derived-factor 2 (Nrf-2) and heme oxygenase-1 (HO-1), elevated non-heme iron deposition, lipid peroxidation, interstitial inflammatory cell activation, increased expression of tubular injury markers kidney injury-1 marker (KIM-1) and liver-fatty acid binding protein (L-FABP), podocyte injury, and cell death. Importantly, these indicators of renal oxidative stress and injury were minimal or absent following infusion of Hb or NaNO2 alone. Together, these results suggest that the exposure to NaNO2 in settings associated with increased extracellular Hb may potentiate acute renal toxicity via processes that are independent of NaNO2 induced erythrocyte methemoglobinemia. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Baek, Jin Hyen AU - Zhang, Xiaoyuan AU - Williams, Matthew C AU - Hicks, Wayne AU - Buehler, Paul W AU - D'Agnillo, Felice AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA. ; Laboratory of Biochemistry and Vascular Biology, Division of Hematology Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA. Electronic address: felice.dagnillo@fda.hhs.gov. Y1 - 2015/07/03/ PY - 2015 DA - 2015 Jul 03 SP - 89 EP - 99 VL - 333 KW - Biomarkers KW - 0 KW - Fatty Acid-Binding Proteins KW - Hemoglobins KW - NF-E2-Related Factor 2 KW - Nitrates KW - sodium nitrate KW - 8M4L3H2ZVZ KW - Methemoglobin KW - 9008-37-1 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Index Medicus KW - Hemoglobin KW - Heme KW - Oxidative stress KW - Kidney KW - Nitrite KW - Animals KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Guinea Pigs KW - Lipid Peroxidation -- drug effects KW - Cell Death -- drug effects KW - NF-E2-Related Factor 2 -- metabolism KW - Fatty Acid-Binding Proteins -- metabolism KW - Oxidation-Reduction KW - Heme Oxygenase-1 -- metabolism KW - Methemoglobin -- metabolism KW - Biomarkers -- metabolism KW - Drug Synergism KW - Time Factors KW - Male KW - Kidney -- metabolism KW - Kidney -- pathology KW - Kidney -- drug effects KW - Hemoglobins -- administration & dosage KW - Methemoglobinemia -- pathology KW - Acute Kidney Injury -- blood KW - Nitrates -- administration & dosage KW - Acute Kidney Injury -- pathology KW - Hemoglobins -- toxicity KW - Nitrates -- toxicity KW - Acute Kidney Injury -- chemically induced KW - Oxidative Stress -- drug effects KW - Methemoglobinemia -- blood KW - Methemoglobinemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687999756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Sodium+nitrite+potentiates+renal+oxidative+stress+and+injury+in+hemoglobin+exposed+guinea+pigs.&rft.au=Baek%2C+Jin+Hyen%3BZhang%2C+Xiaoyuan%3BWilliams%2C+Matthew+C%3BHicks%2C+Wayne%3BBuehler%2C+Paul+W%3BD%27Agnillo%2C+Felice&rft.aulast=Baek&rft.aufirst=Jin&rft.date=2015-07-03&rft.volume=333&rft.issue=&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.04.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-17 N1 - Date created - 2015-06-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.04.007 ER - TY - JOUR T1 - Digestibility and Immunoreactivity of Shrimp Extracts Using an In Vitro Digestibility Model with Pepsin and Pancreatin AN - 1787985685; PQ0002928599 AB - Shellfish allergy affects 2% of the adult population in the United States. Identification of allergenic shrimp proteins is needed for improved management and assessment of shrimp allergy. We determined the temporal pepsin and pancreatin stability of total shrimp proteins using simulated physiological digestive conditions in vitro. Gel electrophoresis was used to determine protein stability, whereas immunoreactivity of protease stable proteins was determined using rabbit antigen-specific antibodies. Potential allergenicity of protease stable proteins was determined utilizing human sera from shrimp allergic patients. Total shrimp myofibrillar proteins were pepsin- and pancreatin-stable for up to 1 h after initiating digestion, whereas only pancreatin-stable total shrimp proteins were Immunoglobulin G (IgG) immunoreactive. However, shrimp proteins of 32 and 25 kDa were pepsin and/or pancreatin stable and Immunoglobulin E (IgE) reactive, denoting the stability and potential allergenicity. These findings suggest that this in vitro digestibility model may be useful for the identification of shrimp allergenic proteins that are more resistant to physiologic digestive conditions and may elicit an immunologic response in vivo. JF - Journal of Food Science AU - Toomer, Ondulla T AU - Do, Andrew B AU - Fu, Tong J AU - Williams, Kristina M AD - U.S. Food and Drug Administration, Laurel, MD, 20708, U.S.A. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - T1633 EP - T1639 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 80 IS - 7 SN - 0022-1147, 0022-1147 KW - Environment Abstracts KW - Digestion KW - USA KW - Electrophoresis KW - Decapoda KW - Physiology KW - Proteins KW - Shellfish KW - Allergies KW - ENA 13:Population Planning & Control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787985685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Digestibility+and+Immunoreactivity+of+Shrimp+Extracts+Using+an+In+Vitro+Digestibility+Model+with+Pepsin+and+Pancreatin&rft.au=Toomer%2C+Ondulla+T%3BDo%2C+Andrew+B%3BFu%2C+Tong+J%3BWilliams%2C+Kristina+M&rft.aulast=Toomer&rft.aufirst=Ondulla&rft.date=2015-07-01&rft.volume=80&rft.issue=7&rft.spage=T1633&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2F1750-3841.12917 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Digestion; Electrophoresis; Physiology; Proteins; Shellfish; Allergies; Decapoda; USA DO - http://dx.doi.org/10.1111/1750-3841.12917 ER - TY - JOUR T1 - Comparative Effectiveness of Cardiac Resynchronization Therapy Defibrillators Versus Standard Implantable Defibrillators in Medicare Patients AN - 1768587040; PQ0002267487 AB - Previous analyses have shown that there is lower mortality with cardiac resynchronization therapy defibrillators (CRT-D) in patients with left bundle branch block (LBBB) but demonstrated mixed results in patients without LBBB. We evaluated the comparative effectiveness of CRT-D versus standard implantable defibrillators (ICDs) separately in patients with LBBB and right bundle branch block (RBBB) using Medicare claims data. Medicare records from CRT-D and ICD recipients from 2002 to 2009 that were followed up for up to 48 months were analyzed. We used propensity scores to match patients with ICD to those with CRT-D. In LBBB, 1:1 matching with replacement resulted in 54,218 patients with CRT-D and 20,763 with ICD, and in RBBB, 1:1 matching resulted in 7,298 patients with CRT-D and 7,298 with ICD. In LBBB, CRT-D had a 12% lower risk of heart failure hospitalization or death (hazard ratio [HR] 0.88, 95% confidence interval 0.86 to 0.90) and 5% lower death risk (HR 0.95, 0.92 to 0.97) compared with ICD. In RBBB, CRT-D had a 15% higher risk of heart failure hospitalization or death (HR 1.15, 1.10 to 1.20) and 13% higher death risk (HR 1.13, 1.07 to 1.18). Sensitivity analysis revealed that accounting for covariates not captured in the Medicare database may lead to increased benefit with CRT-D in LBBB and no difference in RBBB. In conclusion, in a large Medicare population, CRT-D was associated with lower mortality in LBBB but higher mortality in RBBB. The absence of certain covariates, in particular those that determine treatment selection, may affect the results of comparative effectiveness studies using claims data. JF - American Journal of Cardiology AU - Zusterzeel, Robbert AU - Canos, Daniel A AU - Sanders, William E AU - Silverman, Henry AU - MaCurdy, Thomas E AU - Worrall, Christopher M AU - Kelman, Jeffrey AU - Marinac-Dabic, Danica AU - Strauss, David G AD - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 79 EP - 84 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 116 IS - 1 SN - 0002-9149, 0002-9149 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Mortality KW - Databases KW - Data processing KW - Defibrillators KW - Risk factors KW - Heart diseases KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768587040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Cardiology&rft.atitle=Comparative+Effectiveness+of+Cardiac+Resynchronization+Therapy+Defibrillators+Versus+Standard+Implantable+Defibrillators+in+Medicare+Patients&rft.au=Zusterzeel%2C+Robbert%3BCanos%2C+Daniel+A%3BSanders%2C+William+E%3BSilverman%2C+Henry%3BMaCurdy%2C+Thomas+E%3BWorrall%2C+Christopher+M%3BKelman%2C+Jeffrey%3BMarinac-Dabic%2C+Danica%3BStrauss%2C+David+G&rft.aulast=Zusterzeel&rft.aufirst=Robbert&rft.date=2015-07-01&rft.volume=116&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Cardiology&rft.issn=00029149&rft_id=info:doi/10.1016%2Fj.amjcard.2015.03.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 25 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Heart; Databases; Mortality; Data processing; Risk factors; Defibrillators; Heart diseases DO - http://dx.doi.org/10.1016/j.amjcard.2015.03.037 ER - TY - JOUR T1 - Improved screening of microcystin genes and toxins in blue-green algal dietary supplements with PCR and a surface plasmon resonance biosensor AN - 1735922478; PQ0002311377 AB - Microcystins (MCs) comprise a group of cyclic heptapeptide toxins that share a common backbone and have two variable l-amino acids that yield at least 21 known analogs of varying potency. These hepatotoxins and potential tumor promoters are produced by certain cyanobacteria, including Microcystis aeruginosa. The cyanobacterium M. aeruginosa blooms in freshwater lakes and can potentially co-occur with other species such as Aphanizomenon flos-aquae, which is targeted and harvested for the production of dietary supplements known as blue-green algae (BGA). BGA supplements are currently marketed in the U.S. and internationally as a product that may elevate mood, increase energy, and alleviate attention deficit hyperactivity disorder. However, the potential for BGA dietary supplements to be contaminated with MCs is of concern, and there are currently no validated methods for detection of MCs in these products. This research focused on establishing screening methods for toxic Microcystis and MCs in BGA supplements. A DNA-based method employing polymerase chain reaction (PCR) was used as a prescreening tool to evaluate the dietary supplements and to detect the presence of toxin genes (i.e., presence of toxic Microcystis). A rapid, sensitive surface plasmon resonance (SPR) biosensor, directed towards recognition of all MC forms, was also developed and validated. This improved SPR biosensor incorporates a commercial Adda-group antibody (Ab) that has the capacity for broader recognition of MCs than previously developed sensors for BGA supplements that rely solely on an arginine-reactive Ab and can quantitate MC levels down to 0.24ng/mL (equivalent to 0.24 mu g per gram of BGA supplement) in less than 10min. Such a rapid, quantitative screening method may allow for further surveillance of BGA products to assist risk assessment efforts, establishment of regulatory guidance levels, and response to potential consumer complaints related to BGA products. The PCR technique and SPR biosensor may be used in concert as prescreening and screening tools, respectively or individually, thereby limiting the number of samples that must be evaluated with confirmatory methods. JF - Harmful Algae AU - Yakes, Betsy Jean AU - Handy, Sara M AU - Kanyuck, Kelsey M AU - DeGrasse, Stacey L AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 9 EP - 16 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 47 SN - 1568-9883, 1568-9883 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Biosensor KW - Blue-green algae KW - Dietary supplements KW - Microcystins KW - PCR KW - Surface plasmon resonance KW - Risk assessment KW - Aphanizomenon flos-aquae KW - Algal blooms KW - Toxicants KW - Sensors KW - Nucleotide sequence KW - Attention deficit hyperactivity disorder KW - Phytoplankton KW - Microcystis aeruginosa KW - Mood KW - Biosensors KW - Microcystis KW - Promoters KW - Lakes KW - Polymerase chain reaction KW - Consumers KW - Algae KW - Screening KW - Freshwater environments KW - Biological poisons KW - Tumors KW - Toxins KW - Antibodies KW - Cyanobacteria KW - surface plasmon resonance KW - Energy KW - DNA KW - O 8010:Books KW - G 07880:Human Genetics KW - Q1 08563:Fishing gear and methods KW - W 30955:Biosensors KW - X 24320:Food Additives & Contaminants KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735922478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harmful+Algae&rft.atitle=Improved+screening+of+microcystin+genes+and+toxins+in+blue-green+algal+dietary+supplements+with+PCR+and+a+surface+plasmon+resonance+biosensor&rft.au=Yakes%2C+Betsy+Jean%3BHandy%2C+Sara+M%3BKanyuck%2C+Kelsey+M%3BDeGrasse%2C+Stacey+L&rft.aulast=Yakes&rft.aufirst=Betsy&rft.date=2015-07-01&rft.volume=47&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Harmful+Algae&rft.issn=15689883&rft_id=info:doi/10.1016%2Fj.hal.2015.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Screening; Algal blooms; Sensors; Toxicants; Biological poisons; Nucleotide sequence; DNA; Polymerase chain reaction; Phytoplankton; Risk assessment; Freshwater environments; Microcystins; Attention deficit hyperactivity disorder; Tumors; Toxins; Biosensors; Mood; Promoters; Antibodies; Lakes; surface plasmon resonance; Energy; Dietary supplements; Consumers; Algae; Microcystis; Aphanizomenon flos-aquae; Cyanobacteria; Microcystis aeruginosa DO - http://dx.doi.org/10.1016/j.hal.2015.05.001 ER - TY - JOUR T1 - Design and validation of a qPCR assay for accurate detection and initial serogrouping of Legionella pneumophila in clinical specimens by the ESCMID Study Group for Legionella Infections (ESGLI) AN - 1709182039; PQ0001861573 AB - Prompt detection of Legionella pneumophila is essential for rapid investigation of legionellosis. Furthermore, as the majority of L. pneumophila infections are caused by serogroup 1 (sg1) strains, rapid identification of such strains can be critical in both routine and outbreak scenarios. The ESCMID Study Group for Legionella Infections (ESGLI) was established in 2012 and immediately identified as a priority the validation of a reliable, easy to perform and interpret, cost-effective qPCR assay to standardise the detection of L. pneumophila DNA amongst members. A novel L. pneumophila assay targeting the mip gene was designed and combined with previously published methodologies amplifying the sg1 marker (wzm) and the green fluorescent protein gene (gfp) internal process control. The resulting triplex assay was validated internationally on the three qPCR platforms used by the majority of European Legionella reference laboratories: ABI 7500 (Life Technologies), LightCycler 480 Instrument II (Roche) and Rotor-Gene Q (Qiagen). Clinical and EQA specimens were tested together with a large panel of strains (251 in total) to validate the assay. The assay proved to be 100 % specific for L. pneumophila and sg1 DNA both in silico and in vitro. Efficiency values for mip and wzm assays ranged between 91.97 and 97.69 %. Limit of detection values estimated with 95 % confidence were adopted for mip and wzm assays on all three qPCR platforms. Inhibition was not observed. This study describes a robust assay that could be widely implemented to standardise the molecular detection of L. pneumophila among ESGLI laboratories and beyond. JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Mentasti, M AU - Kese, D AU - Echahidi, F AU - Uldum, SA AU - Afshar, B AU - David, S AU - Mrazek, J AU - Mendonca, R AU - Harrison, T G AU - Chalker, V J AD - Public Health England, 61 Colindale Avenue, London, NW9 5EQ, UK, vicki.chalker@phe.gov.uk Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 1387 EP - 1393 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 34 IS - 7 SN - 0934-9723, 0934-9723 KW - Microbiology Abstracts B: Bacteriology KW - Legionella pneumophila KW - MIP gene KW - DNA KW - Green fluorescent protein KW - Infection KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709182039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=Design+and+validation+of+a+qPCR+assay+for+accurate+detection+and+initial+serogrouping+of+Legionella+pneumophila+in+clinical+specimens+by+the+ESCMID+Study+Group+for+Legionella+Infections+%28ESGLI%29&rft.au=Mentasti%2C+M%3BKese%2C+D%3BEchahidi%2C+F%3BUldum%2C+SA%3BAfshar%2C+B%3BDavid%2C+S%3BMrazek%2C+J%3BMendonca%2C+R%3BHarrison%2C+T+G%3BChalker%2C+V+J&rft.aulast=Mentasti&rft.aufirst=M&rft.date=2015-07-01&rft.volume=34&rft.issue=7&rft.spage=1387&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-015-2363-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 18 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - MIP gene; Green fluorescent protein; DNA; Infection; Legionella pneumophila DO - http://dx.doi.org/10.1007/s10096-015-2363-4 ER - TY - JOUR T1 - A Comparison of the J-1 Visa Waiver and Loan Repayment Programs in the Recruitment and Retention of Physicians in Rural Nebraska AN - 1707500738 AB - Purpose There is a dearth of literature evaluating the effectiveness of programs aimed at recruiting and retaining physicians in rural Nebraska. Taking advantage of the Nebraska Health Professional Tracking System, this study attempts to comparatively assess the effectiveness of the J-1 visa waiver and state loan repayment programs in the recruitment and retention of physicians in rural Nebraska. Methods A mixed methods approach was used. We tracked 240 physicians who enrolled in the J-1 visa waiver and state loan repayment programs between 1996 and 2012 until 2013. In addition, key informant interviews were conducted to obtain perspectives on the recruitment and retention of physicians in rural Nebraska through the 2 programs. Findings Results from multilevel survival regression analysis indicated that physicians enrolled in the J-1 visa waiver program were more likely to leave rural Nebraska when compared with those enrolled in the state loan repayment program. Participants in the qualitative study, however, cautioned against declaring one program as superior over the other, given that the 2 programs addressed different needs for different communities. In addition, results suggested that fostering the integration of physicians and their families into rural communities might be a way of enhancing retention, regardless of program. Conclusion The findings from this study highlight the complexity of recruitment and retention issues in rural Nebraska and suggest the need for more holistic and family-centered approaches to addressing these issues. JF - The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association AU - Opoku, Samuel T AU - Apenteng, Bettye A AU - Lin, Ge AU - Chen, Li-Wu AU - Palm, David AU - Rauner, Thomas AD - Department of Health Policy Management, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, Georgia. ; Department of Health Services & Administration, College of Public Health, University of Nebraska Medical Center (UNMC), Omaha, Nebraska. ; Office of Rural Health, Nebraska Department of Health and Human Services, Omaha, Nebraska. ; Department of Health Policy Management, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, Georgia. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 300 EP - 309 CY - Washington PB - Wiley Subscription Services, Inc. VL - 31 IS - 3 SN - 0890-765X KW - Public Health And Safety KW - Doctors KW - Effectiveness KW - Rural Communities KW - Health Professions KW - Health Care Services Policy KW - Regression Analysis KW - Qualitative Methods KW - Recruitment KW - Rural Areas KW - Retention KW - Rural communities KW - Tracking KW - Nebraska UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707500738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.atitle=A+Comparison+of+the+J-1+Visa+Waiver+and+Loan+Repayment+Programs+in+the+Recruitment+and+Retention+of+Physicians+in+Rural+Nebraska&rft.au=Opoku%2C+Samuel+T%3BApenteng%2C+Bettye+A%3BLin%2C+Ge%3BChen%2C+Li-Wu%3BPalm%2C+David%3BRauner%2C+Thomas&rft.aulast=Opoku&rft.aufirst=Samuel&rft.date=2015-07-01&rft.volume=31&rft.issue=3&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fjrh.12108 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Date revised - 2015-08-26 N1 - Last updated - 2016-05-16 N1 - SubjectsTermNotLitGenreText - Nebraska DO - http://dx.doi.org/10.1111/jrh.12108 ER - TY - JOUR T1 - Assessment of phthalates/phthalate alternatives in children's toys and childcare articles: Review of the report including conclusions and recommendation of the Chronic Hazard Advisory Panel of the Consumer Product Safety Commission. AN - 1704997578; 25944701 AB - The Consumer Product Safety Commission (CPSC) convened a Chronic Hazard Advisory Panel (CHAP) on Phthalates found in children's toys, and childcare products, and in products used by women of childbearing age. The CHAP conducted a risk assessment on phthalates and phthalate substitutes, and made recommendations to either ban, impose an interim ban, or allow the continued use of phthalates and phthalate substitutes in the above products. After a review of the literature, the evaluation included toxic end points of primary concern, biomonitoring results, extant exposure reconstruction, and epidemiological results. The health end points chosen were associated with the rat phthalate syndrome, which is characterized by malformations of the epididymis, vas deferens, seminal vesicles, prostate, external genitalia (hypospadias), and by cryptorchidism (undescended testes), retention of nipples/areolae, and demasculinization (~incomplete masculinization) of the perineum, resulting in reduced anogenital distance. Risk assessment demonstrated that some phthalates should be permanently banned, removed from the banned list, or remain interim banned. Biomonitoring and toxicology data provided the strongest basis for a mixture risk assessment. In contrast, external exposure data were the weakest and need to be upgraded for epidemiological studies and risk assessments. Such studies would focus on routes and sources. The review presents recommendations and uncertainties. JF - Journal of exposure science & environmental epidemiology AU - Lioy, Paul J AU - Hauser, Russ AU - Gennings, Chris AU - Koch, Holger M AU - Mirkes, Philip E AU - Schwetz, Bernard A AU - Kortenkamp, Andreas AD - Rutgers Environmental and Occupational Health Sciences Institute (EOHSI), Piscataway, New Jersey, USA. ; Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. ; Icahn School of Medicine at Mount Sinai, New York, New York, USA. ; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany. ; University of Washington (retired), Seattle, Washington, USA. ; US Department of Health and Human Services (retired), Washington, District of Columbia, USA. ; Brunel University, London, UK. PY - 2015 SP - 343 EP - 353 VL - 25 IS - 4 KW - Phthalic Acids KW - 0 KW - Plasticizers KW - phthalic acid KW - 6O7F7IX66E KW - Index Medicus KW - Infant KW - Environmental Monitoring KW - North America KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Humans KW - Europe KW - Child Care KW - Child KW - Female KW - Risk Assessment KW - Pregnancy KW - Child, Preschool KW - Consumer Product Safety KW - Environmental Exposure -- analysis KW - Infant Equipment KW - Environmental Exposure -- adverse effects KW - Play and Playthings KW - Plasticizers -- toxicity KW - Plasticizers -- analysis KW - Phthalic Acids -- toxicity KW - Phthalic Acids -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704997578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Assessment+of+phthalates%2Fphthalate+alternatives+in+children%27s+toys+and+childcare+articles%3A+Review+of+the+report+including+conclusions+and+recommendation+of+the+Chronic+Hazard+Advisory+Panel+of+the+Consumer+Product+Safety+Commission.&rft.au=Lioy%2C+Paul+J%3BHauser%2C+Russ%3BGennings%2C+Chris%3BKoch%2C+Holger+M%3BMirkes%2C+Philip+E%3BSchwetz%2C+Bernard+A%3BKortenkamp%2C+Andreas&rft.aulast=Lioy&rft.aufirst=Paul&rft.date=2015-07-01&rft.volume=25&rft.issue=4&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2015.33 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-15 N1 - Date created - 2015-06-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jes.2015.33 ER - TY - JOUR T1 - The Take-Up of Employer-Sponsored Insurance Among Americans with Mental Disorders: Implications for Health Care Reform AN - 1703894159 AB - Little is known about how take-up of private health insurance coverage differs between those with and without mental disorders. This study seeks to fill this gap by using data from the 2004–2008 Medical Expenditure Panel Survey to examine differences in offers and take-up of employer-sponsored insurance (ESI) among adults aged 27–54. Little evidence that mental disorders are associated with take-up of offers of ESI coverage was found. This suggests that take-up rates in the Affordable Care Act (ACA) marketplaces by those with and without mental disorders may be similar. The ACA is especially important to Americans with mental disorders, many of whom lack access to ESI coverage to pay for mental health treatment either through their own job or through a spouse’s job. JF - Journal of Behavioral Health Services & Research AD - Zuvekas, Samuel H; Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, 20853, USA Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 279 EP - 291 CY - Gaithersburg PB - Springer Science & Business Media VL - 42 IS - 3 SN - 1094-3412 KW - Public Health And Safety KW - Coverage KW - Expenditure KW - Health care KW - Health insurance KW - Insurance KW - Mental health services KW - Psychiatric disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703894159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=The+Take-Up+of+Employer-Sponsored+Insurance+Among+Americans+with+Mental+Disorders%3A+Implications+for+Health+Care+Reform&rft.au=Zuvekas%2C+Samuel+H&rft.aulast=Zuvekas&rft.aufirst=Samuel&rft.date=2015-07-01&rft.volume=42&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-015-9459-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-08-13 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.1007/s11414-015-9459-6 ER - TY - JOUR T1 - Commentary on the contributions and future role of occupational exposure science in a vision and strategy for the discipline of exposure science AN - 1701497702; PQ0001720914 AB - Exposure science is a holistic concept without prejudice to exposure source. Traditionally, measurements aimed at mitigating environmental exposures have not included exposures in the workplace, instead considering such exposures to be an internal affair between workers and their employers. Similarly, occupational (or industrial) hygiene has not typically accounted for environmental contributions to poor health at work. Many persons spend a significant amount of their lifetime in the workplace, where they maybe exposed to more numerous chemicals at higher levels than elsewhere in their environment. In addition, workplace chemical exposures and other exogenous stressors may increase epigenetic and germline modifications that are passed on to future generations. We provide a brief history of the development of exposure science from its roots in the assessment of workplace exposures, including an appendix where we detail current resources for education and training in exposure science offered through occupational hygiene organizations. We describe existing successful collaborations between occupational and environmental practitioners in the field of exposure science, which may serve as a model for future interactions. Finally, we provide an integrated vision for the field of exposure science, emphasizing interagency collaboration, the need for complete exposure information in epidemiological studies, and the importance of integrating occupational, environmental, and residential assessments. Our goal is to encourage communication and spur additional collaboration between the fields of occupational and environmental exposure assessment. Providing a more comprehensive approach to exposure science is critical to the study of the "exposome", which conceptualizes the totality of exposures throughout a person's life, not only chemical, but also from diet, stress, drugs, infection, and so on, and the individual response. JF - Journal of Exposure Science and Environmental Epidemiology AU - Harper, Martin AU - Weis, Christopher AU - Pleil, Joachim D AU - Blount, Benjamin C AU - Miller, Aubrey AU - Hoover, Mark D AU - Jahn, Steven AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road MS-3030, Morgantown, West Virginia, USA Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 381 EP - 387 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 25 IS - 4 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Historical account KW - Mitigation KW - Communication KW - Roots KW - Infection KW - Environmental factors KW - Models KW - Workers KW - epigenetics KW - Vision KW - Drugs KW - Occupational exposure KW - Diets KW - Training KW - Appendix KW - Stress KW - Education KW - Communications KW - Hygiene KW - Occupational health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701497702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Commentary+on+the+contributions+and+future+role+of+occupational+exposure+science+in+a+vision+and+strategy+for+the+discipline+of+exposure+science&rft.au=Harper%2C+Martin%3BWeis%2C+Christopher%3BPleil%2C+Joachim+D%3BBlount%2C+Benjamin+C%3BMiller%2C+Aubrey%3BHoover%2C+Mark+D%3BJahn%2C+Steven&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2015-07-01&rft.volume=25&rft.issue=4&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2014.91 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Diets; Communication; Stress; Roots; Appendix; Infection; Environmental factors; Models; Workers; Vision; epigenetics; Hygiene; Drugs; Occupational exposure; Chemicals; Historical account; Mitigation; Training; Education; Communications; Occupational health DO - http://dx.doi.org/10.1038/jes.2014.91 ER - TY - JOUR T1 - Meta-Analysis of the Reduction of Norovirus and Male-Specific Coliphage Concentrations in Wastewater Treatment Plants AN - 1701493251; PQ0001784720 AB - Human norovirus (NoV) is the leading cause of foodborne illness in the United States and Canada. Wastewater treatment plant (WWTP) effluents impacting bivalve mollusk-growing areas are potential sources of NoV contamination. We have developed a meta-analysis that evaluates WWTP influent concentrations and log10 reductions of NoV genotype I (NoV GI; in numbers of genome copies per liter [gc/liter]), NoV genotype II (NoV GII; in gc/liter), and male-specific coliphage (MSC; in number of PFU per liter), a proposed viral surrogate for NoV. The meta-analysis included relevant data (2,943 measurements) reported in the scientific literature through September 2013 and previously unpublished surveillance data from the United States and Canada. Model results indicated that the mean WWTP influent concentration of NoV GII (3.9 log10 gc/liter; 95% credible interval [CI], 3.5, 4.3 log10 gc/liter) is larger than the value for NoV GI (1.5 log10 gc/liter; 95% CI, 0.4, 2.4 log10 gc/liter), with large variations occurring from one WWTP to another. For WWTPs with mechanical systems and chlorine disinfection, mean log10 reductions were -2.4 log10 gc/liter (95% CI, -3.9, -1.1 log10 gc/liter) for NoV GI, -2.7 log10 gc/liter (95% CI, -3.6, -1.9 log10 gc/liter) for NoV GII, and -2.9 log10 PFU per liter (95% CI, -3.4, -2.4 log10 PFU per liter) for MSCs. Comparable values for WWTPs with lagoon systems and chlorine disinfection were -1.4 log10 gc/liter (95% CI, -3.3, 0.5 log10 gc/liter) for NoV GI, -1.7 log10 gc/liter (95% CI, -3.1, -0.3 log10 gc/liter) for NoV GII, and -3.6 log10 PFU per liter (95% CI, -4.8, -2.4 PFU per liter) for MSCs. Within WWTPs, correlations exist between mean NoV GI and NoV GII influent concentrations and between the mean log10 reduction in NoV GII and the mean log10 reduction in MSCs. JF - Applied and Environmental Microbiology AU - Pouillot, Regis AU - Van Doren, Jane M AU - Woods, Jacquelina AU - Plante, Daniel AU - Smith, Mark AU - Goblick, Gregory AU - Roberts, Christopher AU - Locas, Annie AU - Hajen, Walter AU - Stobo, Jeffrey AD - U.S. Food and Drug Administration, College Park, Maryland, USA, Kevin.Calci@fda.hhs.gov. PY - 2015 SP - 4669 EP - 4681 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 14 SN - 0099-2240, 0099-2240 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Disinfection KW - Data processing KW - Contamination KW - Food KW - Chlorine KW - Norovirus KW - Genotypes KW - Effluents KW - Wastewater treatment KW - Lagoons KW - Models KW - Bivalvia KW - Reviews KW - V 22410:Animal Diseases KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701493251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Meta-Analysis+of+the+Reduction+of+Norovirus+and+Male-Specific+Coliphage+Concentrations+in+Wastewater+Treatment+Plants&rft.au=Pouillot%2C+Regis%3BVan+Doren%2C+Jane+M%3BWoods%2C+Jacquelina%3BPlante%2C+Daniel%3BSmith%2C+Mark%3BGoblick%2C+Gregory%3BRoberts%2C+Christopher%3BLocas%2C+Annie%3BHajen%2C+Walter%3BStobo%2C+Jeffrey&rft.aulast=Pouillot&rft.aufirst=Regis&rft.date=2015-07-01&rft.volume=81&rft.issue=14&rft.spage=4669&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00509-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 69 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Genomes; Disinfection; Data processing; Contamination; Food; Reviews; Chlorine; Genotypes; Effluents; Lagoons; Wastewater treatment; Models; Bivalvia; Norovirus DO - http://dx.doi.org/10.1128/AEM.00509-15 ER - TY - JOUR T1 - Dynamic Response of Mycobacterium vanbaalenii PYR-1 to BP Deepwater Horizon Crude Oil AN - 1701493139; PQ0001784701 AB - We investigated the response of the hydrocarbon-degrading Mycobacterium vanbaalenii PYR-1 to crude oil from the BP Deepwater Horizon (DWH) spill, using substrate depletion, genomic, and proteome analyses. M. vanbaalenii PYR-1 cultures were incubated with BP DWH crude oil, and proteomes and degradation of alkanes and polycyclic aromatic hydrocarbons (PAHs) were analyzed at four time points over 30 days. Gas chromatography-mass spectrometry (GC-MS) analysis showed a chain length-dependent pattern of alkane degradation, with C12 and C13 being degraded at the highest rate, although alkanes up to C28 were degraded. Whereas phenanthrene and pyrene were completely degraded, a significantly smaller amount of fluoranthene was degraded. Proteome analysis identified 3,948 proteins, with 876 and 1,859 proteins up- and downregulated, respectively. We observed dynamic changes in protein expression during BP crude oil incubation, including transcriptional factors and transporters potentially involved in adaptation to crude oil. The proteome also provided a molecular basis for the metabolism of the aliphatic and aromatic hydrocarbon components in the BP DWH crude oil, which included upregulation of AlkB alkane hydroxylase and an expression pattern of PAH-metabolizing enzymes different from those in previous proteome expression studies of strain PYR-1 incubated with pure or mixed PAHs, particularly the ring-hydroxylating oxygenase (RHO) responsible for the initial oxidation of aromatic hydrocarbons. Based on these results, a comprehensive cellular response of M. vanbaalenii PYR-1 to BP crude oil was proposed. This study increases our fundamental understanding of the impact of crude oil on the cellular response of bacteria and provides data needed for development of practical bioremediation applications. JF - Applied and Environmental Microbiology AU - Kim, Seong-Jae AU - Kweon, Ohgew AU - Sutherland, John B AU - Kim, Hyun-Lee AU - Jones, Richard C AU - Burback, Brian L AU - Graves, Steven W AU - Psurny, Edward AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, Arkansas, USA, carl.cerniglia@fda.hhs.gov. PY - 2015 SP - 4263 EP - 4276 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 13 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Alkanes KW - Fluoranthene KW - Mycobacterium vanbaalenii KW - Polycyclic aromatic hydrocarbons KW - Bioremediation KW - Data processing KW - Adaptations KW - Enzymes KW - Transcription KW - Cell culture KW - Pyrene KW - Mass spectroscopy KW - Oil KW - Phenanthrene KW - Gas chromatography KW - Transcription factors KW - Oxidation KW - Aromatic hydrocarbons KW - genomics KW - Hydroxylase KW - Oxygenase KW - Metabolism KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701493139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Dynamic+Response+of+Mycobacterium+vanbaalenii+PYR-1+to+BP+Deepwater+Horizon+Crude+Oil&rft.au=Kim%2C+Seong-Jae%3BKweon%2C+Ohgew%3BSutherland%2C+John+B%3BKim%2C+Hyun-Lee%3BJones%2C+Richard+C%3BBurback%2C+Brian+L%3BGraves%2C+Steven+W%3BPsurny%2C+Edward%3BCerniglia%2C+Carl+E&rft.aulast=Kim&rft.aufirst=Seong-Jae&rft.date=2015-07-01&rft.volume=81&rft.issue=13&rft.spage=4263&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00730-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 63 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Alkanes; Fluoranthene; Polycyclic aromatic hydrocarbons; Adaptations; Data processing; Bioremediation; Transcription; Enzymes; Cell culture; Pyrene; Mass spectroscopy; Oil; Phenanthrene; Gas chromatography; Transcription factors; Oxidation; Aromatic hydrocarbons; genomics; Hydroxylase; Oxygenase; Metabolism; Mycobacterium vanbaalenii DO - http://dx.doi.org/10.1128/AEM.00730-15 ER - TY - JOUR T1 - Characterization of Pre-Antibiotic Era Klebsiella pneumoniae Isolates with Respect to Antibiotic/Disinfectant Susceptibility and Virulence in Galleria mellonella AN - 1701493097; PQ0001784626 AB - The EGD Murray collection consists of approximately 500 clinical bacterial isolates, mainly Enterobacteriaceae, isolated from around the world between 1917 and 1949. A number of these "Murray" isolates have subsequently been identified as Klebsiella pneumoniae. Antimicrobial susceptibility testing of these isolates showed that over 30% were resistant to penicillins due to the presence of diverse blaSHV beta -lactamase genes. Analysis of susceptibility to skin antiseptics and triclosan showed that while the Murray isolates displayed a range of MIC/minimal bactericidal concentration (MBC) values, the mean MIC value was lower than that for more modern K. pneumoniae isolates tested. All Murray isolates contained the cation efflux gene cepA, which is involved in disinfectant resistance, but those that were more susceptible to chlorhexidine were found to have a 9- or 18-bp insertion in this gene. Susceptibility to other disinfectants, e.g., H2O2, in the Murray isolates was comparable to that in modern K. pneumoniae isolates. The Murray isolates were also less virulent in Galleria and had a different complement of putative virulence factors than the modern isolates, with the exception of an isolate related to the modern lineage CC23. More of the modern isolates (41% compared to 8%) are classified as good/very good biofilm formers, but there was overlap in the two populations. This study demonstrated that a significant proportion of the Murray Klebsiella isolates were resistant to penicillins before their routine use. This collection of pre-antibiotic era isolates may provide significant insights into adaptation in K. pneumoniae in relation to biocide susceptibility. JF - Antimicrobial Agents & Chemotherapy AU - Wand, Matthew E AU - Baker, Kate S AU - Benthall, Gabriel AU - McGregor, Hannah AU - McCowen, James WI AU - Deheer-Graham, Ana AU - Sutton, J Mark AD - Public Health England, Microbiology Services Division, Salisbury, Wiltshire, United Kingdom, matthew.wand@phe.gov.uk. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 3966 EP - 3972 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - beta -Lactamase KW - Skin KW - Chlorhexidine KW - Adaptations KW - virulence factors KW - Antibiotics KW - Minimum inhibitory concentration KW - Penicillin KW - Antimicrobial agents KW - Disinfectants KW - Cations KW - Antiseptics KW - Hydrogen peroxide KW - Biofilms KW - Biocides KW - Galleria mellonella KW - Triclosan KW - Enterobacteriaceae KW - Klebsiella pneumoniae KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701493097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Characterization+of+Pre-Antibiotic+Era+Klebsiella+pneumoniae+Isolates+with+Respect+to+Antibiotic%2FDisinfectant+Susceptibility+and+Virulence+in+Galleria+mellonella&rft.au=Wand%2C+Matthew+E%3BBaker%2C+Kate+S%3BBenthall%2C+Gabriel%3BMcGregor%2C+Hannah%3BMcCowen%2C+James+WI%3BDeheer-Graham%2C+Ana%3BSutton%2C+J+Mark&rft.aulast=Wand&rft.aufirst=Matthew&rft.date=2015-07-01&rft.volume=59&rft.issue=7&rft.spage=3966&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.05009-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 43 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Adaptations; Chlorhexidine; Skin; beta -Lactamase; virulence factors; Antibiotics; Minimum inhibitory concentration; Penicillin; Antimicrobial agents; Disinfectants; Cations; Hydrogen peroxide; Antiseptics; Biocides; Biofilms; Triclosan; Galleria mellonella; Enterobacteriaceae; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/AAC.05009-14 ER - TY - JOUR T1 - Chromatin Changes at the PPAR- gamma 2 Promoter During Bone Marrow-Derived Multipotent Stromal Cell Culture Correlate With Loss of Gene Activation Potential AN - 1701477420; PQ0001681712 AB - Bone marrow-derived multipotent stromal cells (BM-MSCs) display a broad range of therapeutically valuable properties, including the capacity to form skeletal tissues and dampen immune system responses. However, to use BM-MSCs in a clinical setting, amplification is required, which may introduce epigenetic changes that affect biological properties. Here we used chromatin immunoprecipitation to compare post-translationally modified histones at a subset of gene promoters associated with developmental and environmental plasticity in BM-MSCs from multiple donors following culture expansion. At many locations, we observed localization of both transcriptionally permissive (H3K4me3) and repressive (H3K27me3) histone modifications. These chromatin signatures were consistent among BM-MSCs from multiple donors. Since promoter activity depends on the relative levels of H3K4me3 and H3K27me3, we examined the ratio of H3K4me3 to H3K27me3 (K4/K27) at promoters during culture expansion. The H3K4me3 to H3K27me3 ratios were maintained at most assayed promoters over time. The exception was the adipose-tissue specific promoter for the PPAR- gamma 2 isoform of PPAR- gamma , which is a critical positive regulator of adipogenesis. At PPAR- gamma 2, we observed a change in K4/K27 levels favoring the repressed chromatin state during culture. This change correlated with diminished promoter activity in late passage cells exposed to adipogenic stimuli. In contrast to BM-MSCs and osteoblasts, lineage-restricted preadipocytes exhibited levels of H3K4me3 and H3K27me3 that favored the permissive chromatin state at PPAR- gamma 2. These results demonstrate that locus-specific changes in H3K4me3 and H3K27me3 levels can occur during BM-MSC culture that may affect their properties. Stem Cells 2015; 33:2169-2181 JF - Stem Cells AU - Lynch, Patrick J AU - Thompson, Elaine E AU - McGinnis, Kathleen AU - Rovira Gonzalez, Yazmin I AU - Lo Surdo, Jessica AU - Bauer, Steven R AU - Hursh, Deborah A AD - Cellular and Tissue Therapies Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 2169 EP - 2181 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 33 IS - 7 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Plasticity (developmental) KW - Histones KW - stromal cells KW - Chromatin KW - Immune system KW - Preadipocytes KW - Immunoprecipitation KW - Bone marrow KW - Transcription KW - Cell culture KW - Promoters KW - Osteoblasts KW - Stem cells KW - Post-translation KW - epigenetics KW - adipogenesis KW - Transcription activation KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701477420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Chromatin+Changes+at+the+PPAR-+gamma+2+Promoter+During+Bone+Marrow-Derived+Multipotent+Stromal+Cell+Culture+Correlate+With+Loss+of+Gene+Activation+Potential&rft.au=Lynch%2C+Patrick+J%3BThompson%2C+Elaine+E%3BMcGinnis%2C+Kathleen%3BRovira+Gonzalez%2C+Yazmin+I%3BLo+Surdo%2C+Jessica%3BBauer%2C+Steven+R%3BHursh%2C+Deborah+A&rft.aulast=Lynch&rft.aufirst=Patrick&rft.date=2015-07-01&rft.volume=33&rft.issue=7&rft.spage=2169&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/10.1002%2Fstem.1967 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Plasticity (developmental); Histones; Chromatin; stromal cells; Immune system; Preadipocytes; Bone marrow; Immunoprecipitation; Transcription; Cell culture; Osteoblasts; Promoters; Stem cells; Post-translation; epigenetics; adipogenesis; Transcription activation DO - http://dx.doi.org/10.1002/stem.1967 ER - TY - JOUR T1 - Phase I trial of systemic intravenous infusion of interleukin-13-Pseudomonas exotoxin in patients with metastatic adrenocortical carcinoma. AN - 1696885993; 25767039 AB - Adrenocortical carcinoma (ACC) is a rare but lethal malignancy without effective current therapy for metastatic disease. IL-13-PE is a recombinant cytotoxin consisting of human interleukin-13 (IL-13) and a truncated form of Pseudomonas exotoxin A (PE). The main objectives of this Phase I dose-escalation trial were to assess the maximum-tolerated dose (MTD), safety, and pharmacokinetics (PK) of IL-13-PE in patients with metastatic ACC. Eligible patients had confirmed IL-13 receptor alpha 2 (IL-13Rα2) expressions in their tumors. IL-13-PE at dose of 1-2 μg/kg was administered intravenously (IV) on day 1, 3, and 5 in a 4-week cycle. Six patients received 1 μg/kg and two patients received 2 μg/kg of IL-13-PE. Dose-limiting toxicity was observed at 2 μg/kg, at which patients exhibited thrombocytopenia and renal insufficiency without requiring dialysis. PK analysis demonstrated that at MTD, the mean maximum serum concentration (Cmax ) of IL-13-PE was 21.0 ng/mL, and the terminal half-life of IL-13-PE was 30-39 min. Two (25%) of the eight patients had baseline neutralizing antibodies against PE. Three (75%) of the remaining four tested patients developed neutralizing antibodies against IL-13-PE within 14-28 days of initial treatment. Of the five patients treated at MTD and assessed for response, one patient had stable disease for 5.5 months before disease progression; the others progressed within 1-2 months. In conclusion, systemic IV administration of IL-13-PE is safe at 1 μg/kg. All tested patients developed high levels of neutralizing antibodies during IL-13-PE treatment. Use of strategies for immunodepletion before IL-13-PE treatment should be considered in future trials. © 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. JF - Cancer medicine AU - Liu-Chittenden, Yi AU - Jain, Meenu AU - Kumar, Parag AU - Patel, Dhaval AU - Aufforth, Rachel AU - Neychev, Vladimir AU - Sadowski, Samira AU - Gara, Sudheer K AU - Joshi, Bharat H AU - Cottle-Delisle, Candice AU - Merkel, Roxanne AU - Yang, Lily AU - Miettinen, Markku AU - Puri, Raj K AU - Kebebew, Electron AD - Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. ; Clinical Pharmacokinetics Research Laboratory, Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, Maryland. ; Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. ; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 1060 EP - 1068 VL - 4 IS - 7 KW - Antibodies, Neutralizing KW - 0 KW - Antineoplastic Agents KW - Bacterial Toxins KW - Exotoxins KW - Interleukin-13 KW - Recombinant Fusion Proteins KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Phase I KW - systemic administration KW - metastatic adrenocortical carcinoma KW - IL-13-PE KW - pharmacokinetics KW - maximum-tolerated dose KW - Young Adult KW - Infusions, Intravenous KW - Humans KW - Aged KW - Adult KW - Treatment Outcome KW - Neoplasm Metastasis KW - Middle Aged KW - Antibodies, Neutralizing -- blood KW - Maximum Tolerated Dose KW - Adolescent KW - Retreatment KW - Female KW - Male KW - Adrenocortical Carcinoma -- therapy KW - Recombinant Fusion Proteins -- pharmacokinetics KW - Recombinant Fusion Proteins -- adverse effects KW - Antineoplastic Agents -- administration & dosage KW - Antineoplastic Agents -- pharmacokinetics KW - Adrenal Cortex Neoplasms -- therapy KW - Recombinant Fusion Proteins -- administration & dosage KW - Adrenocortical Carcinoma -- drug therapy KW - Antineoplastic Agents -- adverse effects KW - Adrenocortical Carcinoma -- pathology KW - Adrenal Cortex Neoplasms -- pathology KW - Adrenal Cortex Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1696885993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+medicine&rft.atitle=Phase+I+trial+of+systemic+intravenous+infusion+of+interleukin-13-Pseudomonas+exotoxin+in+patients+with+metastatic+adrenocortical+carcinoma.&rft.au=Liu-Chittenden%2C+Yi%3BJain%2C+Meenu%3BKumar%2C+Parag%3BPatel%2C+Dhaval%3BAufforth%2C+Rachel%3BNeychev%2C+Vladimir%3BSadowski%2C+Samira%3BGara%2C+Sudheer+K%3BJoshi%2C+Bharat+H%3BCottle-Delisle%2C+Candice%3BMerkel%2C+Roxanne%3BYang%2C+Lily%3BMiettinen%2C+Markku%3BPuri%2C+Raj+K%3BKebebew%2C+Electron&rft.aulast=Liu-Chittenden&rft.aufirst=Yi&rft.date=2015-07-01&rft.volume=4&rft.issue=7&rft.spage=1060&rft.isbn=&rft.btitle=&rft.title=Cancer+medicine&rft.issn=2045-7634&rft_id=info:doi/10.1002%2Fcam4.449 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-06 N1 - Date created - 2015-07-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Cancer Res Clin Oncol. 2010 Jun;136(6):839-46 [19916021] Neurosurgery. 2007 Nov;61(5):1031-7; discussion 1037-8 [18091279] Nat Rev Endocrinol. 2011 Jun;7(6):323-35 [21386792] Clin Cancer Res. 2011 Sep 15;17(18):5858-66 [21813634] Hum Gene Ther Methods. 2012 Apr;23(2):137-47 [22612657] J Clin Oncol. 2007 Mar 1;25(7):837-44 [17327604] Cancer. 2006 Sep 15;107(6):1407-18 [16902988] Mol Cancer Ther. 2008 Jun;7(6):1579-87 [18566228] Cancer. 2008 Dec 1;113(11):3130-6 [18973179] Best Pract Res Clin Endocrinol Metab. 2009 Apr;23(2):273-89 [19500769] Clin Cancer Res. 2010 Jan 15;16(2):577-86 [20068108] Cancer. 2012 Nov 15;118(22):5698-708 [22570059] Eur J Cancer. 2013 Jul;49(11):2579-86 [23561851] Cancer Res. 2000 Mar 1;60(5):1168-72 [10728667] Mol Med. 2000 May;6(5):440-9 [10952023] Clin Cancer Res. 2002 Jun;8(6):1948-56 [12060640] Clin Cancer Res. 2003 Dec 15;9(17):6381-8 [14695138] J Biol Chem. 1995 Jul 14;270(28):16775-80 [7622490] Blood. 1996 May 15;87(10):4333-9 [8639793] Clin Cancer Res. 1997 Feb;3(2):151-6 [9815666] Protein Expr Purif. 2005 Feb;39(2):189-98 [15642470] Nat Med. 2006 Jan;12(1):99-106 [16327802] World J Surg. 2006 May;30(5):872-8 [16680602] Technol Cancer Res Treat. 2006 Jun;5(3):239-50 [16700620] Neurosurg Focus. 2006;20(4):E15 [16709020] Neuro Oncol. 2010 Aug;12(8):871-81 [20511192] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cam4.449 ER - TY - JOUR T1 - Amsterdam's STI/HIV programme: an innovative strategy to achieve and enhance the participation of migrant community-based organisations AN - 1695993925; 4687892 JF - Health education journal AU - Wagemakers, Annemarie AU - Husen, Gwen van AU - Barrett, Jennifer AU - Koelen, Maria AD - Wageningen University ; Public Health Service Amsterdam ; University of South Wales Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 411 EP - 423 VL - 74 IS - 4 SN - 0017-8969, 0017-8969 KW - Sociology KW - Community KW - Evaluation KW - Community organization KW - Innovation KW - AIDS KW - Netherlands KW - HIV KW - Migrants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1695993925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+education+journal&rft.atitle=Amsterdam%27s+STI%2FHIV+programme%3A+an+innovative+strategy+to+achieve+and+enhance+the+participation+of+migrant+community-based+organisations&rft.au=Wagemakers%2C+Annemarie%3BHusen%2C+Gwen+van%3BBarrett%2C+Jennifer%3BKoelen%2C+Maria&rft.aulast=Wagemakers&rft.aufirst=Annemarie&rft.date=2015-07-01&rft.volume=74&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Health+education+journal&rft.issn=00178969&rft_id=info:doi/10.1177%2F0017896914542665 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-07-14 N1 - Last updated - 2015-07-14 N1 - SubjectsTermNotLitGenreText - 4551; 5703 3617 6220; 8037; 2603; 2613 11878 9003; 482 3617 6220; 6564 12622; 275 462 129 DO - http://dx.doi.org/10.1177/0017896914542665 ER - TY - JOUR T1 - Regulatory Forum Opinion Piece*: Transgenic/Alternative Carcinogenicity Assays: A Retrospective Review of Studies Submitted to CDER/FDA 1997-2014. AN - 1694509093; 25630682 AB - The International Conference on Harmonization (ICH; S1B of 1997) allows a second species carcinogenicity study to be an alternative to one of the traditional 2-year studies. In the past 17 years, the FDA's Center for Drug Evaluation and Research's (CDER) Executive Carcinogenicity Assessment Committee received 269 alternative carcinogenicity assay protocols for review. This committee's recommendations regarding choice of animal model and dose selection are generally followed by sponsors conducting these studies to increase the acceptability of such studies. The P53(+/-) assay is generally considered appropriate for genotoxic products, and the TgRasH2 assay is appropriate for non-genotoxic or genotoxic drugs. In the United States, the TgAC assay is not used any more and the animals are no longer available. The TgAC assay can detect both tumor promoters and complete carcinogens, and consequently more than half of the dermal TgAC assays resulted in a positive assessment. Currently, more than 75% of mouse carcinogenicity studies are conducted in TgRasH2 mice. Behavior of genotoxic and non-genotoxic drugs in the various assays is reviewed. © 2015 by The Author(s). JF - Toxicologic pathology AU - Jacobs, Abigail C AU - Brown, Paul C AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA Abigail.Jacobs@fda.hhs.gov. ; Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 605 EP - 610 VL - 43 IS - 5 KW - Index Medicus KW - carcinogenicity KW - transgenic KW - regulatory KW - FDA. KW - United States KW - Animals KW - United States Food and Drug Administration KW - Retrospective Studies KW - Mice KW - Mice, Transgenic KW - Carcinogenicity Tests -- standards KW - Drug Evaluation -- legislation & jurisprudence KW - Carcinogenicity Tests -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694509093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Regulatory+Forum+Opinion+Piece*%3A+Transgenic%2FAlternative+Carcinogenicity+Assays%3A+A+Retrospective+Review+of+Studies+Submitted+to+CDER%2FFDA+1997-2014.&rft.au=Jacobs%2C+Abigail+C%3BBrown%2C+Paul+C&rft.aulast=Jacobs&rft.aufirst=Abigail&rft.date=2015-07-01&rft.volume=43&rft.issue=5&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623314566241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-21 N1 - Date created - 2015-07-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623314566241 ER - TY - JOUR T1 - Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin. AN - 1693184156; 25837581 AB - Stromal interaction molecule 1 (STIM1) is a Ca(2+) sensor protein that initiates store-operated calcium entry (SOCE). STIM1 is known to be involved in the chemoattractant signaling pathway for FPR1 in cell lines, but its role in in vivo functioning of neutrophils is unclear. Plaque-type psoriasis is a chronic inflammatory skin disorder associated with chemoattractants driving neutrophils into the epidermis. We investigated the involvement of STIM1 in neutrophil chemotaxis in vitro, as well as during chronic psoriatic inflammation. To this end, we used conditional knockout (KO) mice lacking STIM1 in cells of myeloid lineage (STIM1(fl/fl) LysM-cre). We demonstrate that STIM1 is required for chemotaxis because of multiple chemoattractants in mouse neutrophils in vitro. Using an imiquimod-induced psoriasis-like skin model, we show that KO mice had less neutrophil infiltration in the epidermis than controls, whereas neither chemoattractant production in the epidermis nor macrophage migration was decreased. KO mice displayed a more rapid reversal of the outward signs of psoriasis (plaques). Thus, KO of STIM1 impairs neutrophil contribution to psoriatic inflammation. Our data provide new insights to our understanding of how STIM1 orchestrates the cellular behavior underlying chemotaxis and illustrate the important role of SOCE in a disease-related pathologic model. © FASEB. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Steinckwich, Natacha AU - Myers, Page AU - Janardhan, Kyathanahalli S AU - Flagler, Norris D AU - King, Debra AU - Petranka, John G AU - Putney, James W AD - *Signal Transduction Laboratory, Comparative Medicine Branch, Integrated Laboratory Systems, Incorporated, Cellular and Molecular Pathology Branch,National Toxicology Program, and Special Techniques Group, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. ; *Signal Transduction Laboratory, Comparative Medicine Branch, Integrated Laboratory Systems, Incorporated, Cellular and Molecular Pathology Branch,National Toxicology Program, and Special Techniques Group, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA putney@niehs.nih.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 3003 EP - 3013 VL - 29 IS - 7 KW - Aminoquinolines KW - 0 KW - Calcium Channels KW - Membrane Proteins KW - Neoplasm Proteins KW - RNA, Small Interfering KW - STIM1 protein, human KW - Stim1 protein, mouse KW - Stromal Interaction Molecule 1 KW - imiquimod KW - P1QW714R7M KW - Index Medicus KW - calcium signaling KW - leukocyte migration KW - chronic inflammatory disease KW - Animals KW - Skin -- physiopathology KW - Neoplasm Proteins -- antagonists & inhibitors KW - HL-60 Cells KW - Humans KW - Skin -- pathology KW - Disease Models, Animal KW - RNA, Small Interfering -- genetics KW - Neutrophil Infiltration -- physiology KW - Mice KW - Membrane Proteins -- genetics KW - Chemotaxis, Leukocyte -- physiology KW - Mice, Knockout KW - Aminoquinolines -- toxicity KW - Neoplasm Proteins -- physiology KW - Neoplasm Proteins -- genetics KW - In Vitro Techniques KW - Membrane Proteins -- antagonists & inhibitors KW - Signal Transduction KW - Membrane Proteins -- physiology KW - Calcium Channels -- deficiency KW - Neutrophils -- pathology KW - Calcium Channels -- physiology KW - Psoriasis -- physiopathology KW - Psoriasis -- pathology KW - Neutrophils -- physiology KW - Calcium Channels -- genetics KW - Psoriasis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1693184156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Role+of+the+store-operated+calcium+entry+protein%2C+STIM1%2C+in+neutrophil+chemotaxis+and+infiltration+into+a+murine+model+of+psoriasis-inflamed+skin.&rft.au=Steinckwich%2C+Natacha%3BMyers%2C+Page%3BJanardhan%2C+Kyathanahalli+S%3BFlagler%2C+Norris+D%3BKing%2C+Debra%3BPetranka%2C+John+G%3BPutney%2C+James+W&rft.aulast=Steinckwich&rft.aufirst=Natacha&rft.date=2015-07-01&rft.volume=29&rft.issue=7&rft.spage=3003&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/10.1096%2Ffj.14-265215 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-14 N1 - Date created - 2015-07-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1978 May;75(5):2458-62 [276884] J Invest Dermatol. 2002 Jan;118(1):49-54 [11851875] J Immunol. 2011 Feb 15;186(4):2182-91 [21239714] Toxicol Pathol. 2011 Feb;39(2):435-48 [21300792] J Immunol. 2011 Jul 1;187(1):472-81 [21632714] J Immunol. 2012 Jan 1;188(1):462-9 [22131335] Cell Physiol Biochem. 2012;30(1):221-37 [22759969] Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C490-8 [22673622] Blood. 2014 Apr 3;123(14):2238-49 [24493668] Oncogene. 2014 May 1;33(18):2307-16 [23686305] J Cell Biol. 1990 Jan;110(1):43-52 [2295684] J Cell Biol. 1991 Mar;112(6):1249-57 [1900302] Cell. 1996 Feb 9;84(3):359-69 [8608589] Cell. 1996 Feb 9;84(3):371-9 [8608590] Biochem J. 1996 Jul 15;317 ( Pt 2):403-9 [8713065] Cell. 1996 Nov 15;87(4):601-6 [8929529] Biochem Biophys Res Commun. 1997 Jan 13;230(2):258-61 [9016761] Nature. 2006 May 11;441(7090):179-85 [16582901] Science. 2006 May 26;312(5777):1220-3 [16645049] Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9357-62 [16751269] Curr Med Chem. 2007;14(6):681-7 [17346155] Ann Biomed Eng. 2008 Apr;36(4):632-46 [18278555] Nat Immunol. 2008 Apr;9(4):432-43 [18327260] Methods. 2008 Nov;46(3):204-12 [18929662] J Immunol. 2009 May 1;182(9):5836-45 [19380832] Biochem Pharmacol. 2009 Sep 1;78(5):504-13 [19433064] N Engl J Med. 2009 Jul 30;361(5):496-509 [19641206] Blood. 2010 Jan 21;115(3):657-66 [19965684] J Leukoc Biol. 2010 Jul;88(1):57-68 [20400677] Transgenic Res. 1999 Aug;8(4):265-77 [10621974] Pharmacol Rev. 2000 Mar;52(1):145-76 [10699158] J Invest Dermatol. 2000 May;114(5):976-83 [10771480] J Am Acad Dermatol. 2000 Aug;43(2 Pt 2):391-5 [10901732] Blood. 2000 Dec 1;96(12):3816-22 [11090065] Nat Rev Rheumatol. 2010 Dec;6(12):704-14 [20877306] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1096/fj.14-265215 ER - TY - JOUR T1 - Risk of cancer among firefighters in California, 1988-2007 AN - 1691292299; PQ0001650567 AB - Background Most studies of firefighter cancer risks were conducted prior to 1990 and do not reflect risk from advances in building materials. Methods A case-control study using California Cancer Registry data (1988-2007) was conducted to evaluate the risk of cancer among firefighters, stratified by race. Results This study identified 3,996 male firefighters with cancer. Firefighters were found to have a significantly elevated risk for melanoma (odds ratio [OR]=1.8; 95% confidence interval [CI] 1.4-2.1), multiple myeloma (OR 1.4; 95%CI 1.0-1.8), acute myeloid leukemia (OR 1.4; 95%CI 1.0-2.0), and cancers of the esophagus (OR 1.6; 95%CI 1.2-2.1), prostate (OR 1.5; 95%CI 1.3-1.7), brain (OR 1.5; 95%CI 1.2-2.0), and kidney (OR 1.3; 95%CI 1.0-1.6). Conclusions In addition to observing cancer findings consistent with previous research, this study generated novel findings for firefighters with race/ethnicity other than white. It provides additional evidence to support the association between firefighting and several specific cancers. Am. J. Ind. Med. 58:715-729, 2015. copyright 2015 This article has been contributed to by US Government employees and their work is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Tsai, Rebecca J AU - Luckhaupt, Sara E AU - Schumacher, Pam AU - Cress, Rosemary D AU - Deapen, Dennis M AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 715 EP - 729 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 7 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Health risks KW - Leukemia KW - Multiple myeloma KW - Firefighter services KW - Brain KW - Kidney KW - Construction materials KW - USA, California KW - Cancer KW - Ethnic groups KW - Melanoma KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691292299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Risk+of+cancer+among+firefighters+in+California%2C+1988-2007&rft.au=Tsai%2C+Rebecca+J%3BLuckhaupt%2C+Sara+E%3BSchumacher%2C+Pam%3BCress%2C+Rosemary+D%3BDeapen%2C+Dennis+M%3BCalvert%2C+Geoffrey+M&rft.aulast=Tsai&rft.aufirst=Rebecca&rft.date=2015-07-01&rft.volume=58&rft.issue=7&rft.spage=715&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22466 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2015-07-23 N1 - SubjectsTermNotLitGenreText - Leukemia; Health risks; Multiple myeloma; Firefighter services; Kidney; Brain; Construction materials; Ethnic groups; Cancer; Melanoma; USA, California DO - http://dx.doi.org/10.1002/ajim.22466 ER - TY - JOUR T1 - Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells. AN - 1691016245; 25870318 AB - The use of usnic acid as a weight loss agent is a safety concern due to reports of acute liver failure in humans. Previously we demonstrated that usnic acid induces apoptosis and cytotoxicity in hepatic HepG2 cells. We also demonstrated that usnic acid induces autophagy as a survival mechanism against its cytotoxicity. In this study, we investigated and characterized further molecular mechanisms underlying the toxicity of usnic acid in HepG2 cells. We found that usnic acid causes endoplasmic reticulum (ER) stress demonstrated by the increased expression of typical ER stress markers, including CHOP, ATF-4, p-eIF2α, and spliced XBP1. Usnic acid inhibited the secretion of Gaussia luciferase measured by an ER stress reporter assay. An ER stress inhibitor 4-phenylbutyrate attenuated usnic acid-induced apoptosis. Moreover, usnic acid significantly increased the cytosolic free Ca(2+) concentration. Usnic acid increased the expression of calcium release-activated calcium channel protein 1 (CRAM1 or ORAI1) and stromal interaction molecule 1, two key components of store-operated calcium entry (SOCE), which is the major Ca(2+) influx pathway in non-excitable cells, this finding was also confirmed in primary rat hepatocytes. Furthermore, knockdown of ORAI1 prevented ER stress and ATP depletion in response to usnic acid. In contrast, overexpression of ORAI1 increased ER stress and ATP depletion caused by usnic acid. Taken together, our results suggest that usnic acid disturbs calcium homeostasis, induces ER stress, and that usnic acid-induced cellular damage occurs at least partially via activation of the Ca(2+) channel of SOCE. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Chen, Si AU - Zhang, Zhuhong AU - Wu, Yuanfeng AU - Shi, Qiang AU - Yan, Hua AU - Mei, Nan AU - Tolleson, William H AU - Guo, Lei AD - *Division of Biochemical Toxicology, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, Tianjin Medical University General Hospital, Tianjin 300052, China and Division of Systems Biology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079. ; *Division of Biochemical Toxicology, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, Tianjin Medical University General Hospital, Tianjin 300052, China and Division of Systems Biology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079 *Division of Biochemical Toxicology, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, Tianjin Medical University General Hospital, Tianjin 300052, China and Division of Systems Biology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079. ; *Division of Biochemical Toxicology, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, Tianjin Medical University General Hospital, Tianjin 300052, China and Division of Systems Biology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079 lei.guo@fda.hhs.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 116 EP - 126 VL - 146 IS - 1 KW - Benzofurans KW - 0 KW - usnic acid KW - 0W584PFJ77 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - apoptosis KW - liver toxicity KW - store operated calcium entry KW - ER stress KW - Hep G2 Cells KW - Humans KW - Endoplasmic Reticulum -- metabolism KW - Calcium -- metabolism KW - Benzofurans -- toxicity KW - Stress, Physiological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691016245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Endoplasmic+Reticulum+Stress+and+Store-Operated+Calcium+Entry+Contribute+to+Usnic+Acid-Induced+Toxicity+in+Hepatic+Cells.&rft.au=Chen%2C+Si%3BZhang%2C+Zhuhong%3BWu%2C+Yuanfeng%3BShi%2C+Qiang%3BYan%2C+Hua%3BMei%2C+Nan%3BTolleson%2C+William+H%3BGuo%2C+Lei&rft.aulast=Chen&rft.aufirst=Si&rft.date=2015-07-01&rft.volume=146&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv075 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-07 N1 - Date created - 2015-06-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv075 ER - TY - JOUR T1 - Comparative Risk Assessment of Formulation Changes in Generic Drug Products: A Pharmacology/Toxicology Perspective. AN - 1691016234; 26101235 AB - This review highlights general toxicology concerns caused by formulation differences between generic and innovator drugs. It underscores the importance of a scientific, clinically oriented, evidence-based comparative safety evaluation procedure for generic drugs and discusses representative case studies from a pharmacology-toxicology perspective. For consideration by generic drug industry stakeholders, this article provides an overview of comparative risk assessments for generic drug products. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Rayavarapu, Sree AU - Braithwaite, Elena AU - Dorsam, Robert AU - Osterhout, James AU - Furlong, Lesley-Anne AU - Shetty, Daiva AU - Peters, John R AD - Division of Clinical Review, Office of Bioequivalence, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993 sree.rayavarapu@fda.hhs.gov. ; Division of Clinical Review, Office of Bioequivalence, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 2 EP - 10 VL - 146 IS - 1 KW - Drugs, Generic KW - 0 KW - Excipients KW - Index Medicus KW - residual solvents KW - excipients KW - toxicity KW - impurities KW - generics KW - reference listed drug KW - Risk Assessment KW - Drugs, Generic -- adverse effects KW - Chemistry, Pharmaceutical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691016234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Comparative+Risk+Assessment+of+Formulation+Changes+in+Generic+Drug+Products%3A+A+Pharmacology%2FToxicology+Perspective.&rft.au=Rayavarapu%2C+Sree%3BBraithwaite%2C+Elena%3BDorsam%2C+Robert%3BOsterhout%2C+James%3BFurlong%2C+Lesley-Anne%3BShetty%2C+Daiva%3BPeters%2C+John+R&rft.aulast=Rayavarapu&rft.aufirst=Sree&rft.date=2015-07-01&rft.volume=146&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv074 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-07 N1 - Date created - 2015-06-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv074 ER - TY - JOUR T1 - Quantitative Assessment of MRI T2 Response to Kainic Acid Neurotoxicity in Rats in vivo. AN - 1691016229; 25904105 AB - The aim of this study was to assess quantitative changes in T2 relaxation using magnetic resonance imaging approaches in rats exposed to kainic acid to assess the utility of such endpoints as biomarkers of neurotoxicity. Quantitative T2 mapping was performed in 21 rats before and 2, 24, and 48 h after a single ip injection of 10 mg/kg of kainic acid. Three methods of quantifying T2 changes were explored: (1) Thresholding: all voxels exhibiting T2 ≤ 72 ms were designated normal tissue, whereas voxels exhibiting T2 > 72 ms were designated as lesioned tissue; (2) Statistical mapping: T2 maps obtained after treatment were statistically compared with averaged "baseline" maps, voxel-by-voxel; (3) Within-subject difference from baseline: for each individual the baseline T2 map was subtracted from the T2 map obtained after treatment. Based on the follow-up histopathological response there were 9 responders, 7 nonresponders, and 5 animals were not classified due to early sacrifice at 2 h which was too soon after treatment to detect any morphological evidence. The "thresholding" method (1) detected differences between groups only at the later time point of 48 h, the "statistical mapping" approach (2) detected differences 24 and 48 h after treatment, and the "within-subject difference from baseline" method (3) detected statistically significant differences between groups at each time point (2, 24, and 48 h). T2 mapping provides an easily quantifiable biomarker and the quantification method employing the use of the same animal as its own control provides the most sensitive metrics. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Liachenko, Serguei AU - Ramu, Jaivijay AU - Konak, Tetyana AU - Paule, Merle G AU - Hanig, Joseph AD - *Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas and Office of Testing and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak, Maryland Serguei.liachenko@fda.hhs.gov. ; *Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas and Office of Testing and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak, Maryland. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 183 EP - 191 VL - 146 IS - 1 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - toxicity KW - MRI KW - T2 map KW - quantification KW - kainic acid KW - registration KW - rat KW - brain KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Male KW - Magnetic Resonance Imaging -- methods KW - Nervous System -- drug effects KW - Kainic Acid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691016229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Quantitative+Assessment+of+MRI+T2+Response+to+Kainic+Acid+Neurotoxicity+in+Rats+in+vivo.&rft.au=Liachenko%2C+Serguei%3BRamu%2C+Jaivijay%3BKonak%2C+Tetyana%3BPaule%2C+Merle+G%3BHanig%2C+Joseph&rft.aulast=Liachenko&rft.aufirst=Serguei&rft.date=2015-07-01&rft.volume=146&rft.issue=1&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv083 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-07 N1 - Date created - 2015-06-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv083 ER - TY - JOUR T1 - Manganese concentrations in soil and settled dust in an area with historic ferroalloy production. AN - 1690213007; 25335867 AB - Ferroalloy production can release a number of metals into the environment, of which manganese (Mn) is of major concern. Other elements include lead, iron, zinc, copper, chromium, and cadmium. Mn exposure derived from settled dust and suspended aerosols can cause a variety of adverse neurological effects to chronically exposed individuals. To better estimate the current levels of exposure, this study quantified the metal levels in dust collected inside homes (n=85), outside homes (n=81), in attics (n=6), and in surface soil (n=252) in an area with historic ferroalloy production. Metals contained in indoor and outdoor dust samples were quantified using inductively coupled plasma optical emission spectroscopy, whereas attic and soil measurements were made with a X-ray fluorescence instrument. Mean Mn concentrations in soil (4600 μg/g) and indoor dust (870 μg/g) collected within 0.5 km of a plant exceeded levels previously found in suburban and urban areas, but did decrease outside 1.0 km to the upper end of background concentrations. Mn concentrations in attic dust were ~120 times larger than other indoor dust levels, consistent with historical emissions that yielded high airborne concentrations in the region. Considering the potential health effects that are associated with chronic Mn inhalation and ingestion exposure, remediation of soil near the plants and frequent, on-going hygiene indoors may decrease residential exposure and the likelihood of adverse health effects. JF - Journal of exposure science & environmental epidemiology AU - Pavilonis, Brian T AU - Lioy, Paul J AU - Guazzetti, Stefano AU - Bostick, Benjamin C AU - Donna, Filippo AU - Peli, Marco AU - Zimmerman, Neil J AU - Bertrand, Patrick AU - Lucas, Erika AU - Smith, Donald R AU - Georgopoulos, Panos G AU - Mi, Zhongyuan AU - Royce, Steven G AU - Lucchini, Roberto G AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. ; Public Health Service, Reggio Emilia, Italy. ; Lamont-Doherty Earth Observatory, Columbia University, New York City, NY, USA. ; Institute of Occupational Health, University of Brescia, Brescia, Italy. ; School of Health Sciences, Purdue University, West Lafayette, IN, USA. ; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA. ; 1] Institute of Occupational Health, University of Brescia, Brescia, Italy [2] Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA [3] Icahn School of Medicine at Mount Sinai, New York City, NY, USA. PY - 2015 SP - 443 EP - 450 VL - 25 IS - 4 KW - Alloys KW - 0 KW - Dust KW - Soil KW - Soil Pollutants KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Environmental Monitoring KW - Humans KW - Seasons KW - Models, Statistical KW - Child KW - Adolescent KW - Italy KW - Manganese -- analysis KW - Dust -- analysis KW - Environmental Exposure -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Soil -- chemistry KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1690213007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Manganese+concentrations+in+soil+and+settled+dust+in+an+area+with+historic+ferroalloy+production.&rft.au=Pavilonis%2C+Brian+T%3BLioy%2C+Paul+J%3BGuazzetti%2C+Stefano%3BBostick%2C+Benjamin+C%3BDonna%2C+Filippo%3BPeli%2C+Marco%3BZimmerman%2C+Neil+J%3BBertrand%2C+Patrick%3BLucas%2C+Erika%3BSmith%2C+Donald+R%3BGeorgopoulos%2C+Panos+G%3BMi%2C+Zhongyuan%3BRoyce%2C+Steven+G%3BLucchini%2C+Roberto+G&rft.aulast=Pavilonis&rft.aufirst=Brian&rft.date=2015-07-01&rft.volume=25&rft.issue=4&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2014.70 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-15 N1 - Date created - 2015-06-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Arch Neurol. 2000 Apr;57(4):597-9 [10768639] Sci Total Environ. 2000 Jul 10;256(2-3):115-23 [10902839] J Expo Anal Environ Epidemiol. 2000 May-Jun;10(3):227-39 [10910116] Sci Total Environ. 2001 Feb 21;267(1-3):125-40 [11286208] Environ Sci Technol. 2002 Jun 1;36(11):2484-90 [12075809] Environ Res. 2003 Nov;93(3):301-7 [14615241] Pediatrics. 2004 Apr;113(4 Suppl):996-1006 [15060192] Ann N Y Acad Sci. 2004 Mar;1012:209-23 [15105268] Br J Ind Med. 1989 Dec;46(12):856-9 [2611159] Br J Ind Med. 1992 Jan;49(1):25-34 [1733453] Risk Anal. 1992 Jun;12(2):287-99 [1502376] Environ Res. 1994 Feb;64(2):151-80 [8306949] Neurology. 1994 Sep;44(9):1583-6 [7936278] J Toxicol Clin Toxicol. 1999;37(2):293-307 [10382563] Neurotoxicology. 1999 Apr-Jun;20(2-3):145-50 [10385878] Mol Aspects Med. 2005 Aug-Oct;26(4-5):353-62 [16099026] Environ Sci Technol. 2005 Oct 1;39(19):7410-5 [16245809] Neurotoxicology. 2006 Mar;27(2):210-6 [16310252] Neurotoxicology. 2006 May;27(3):347-9 [16337002] Sci Total Environ. 2006 May 15;361(1-3):67-72 [15972228] Environ Pollut. 2006 Sep;143(1):16-23 [16406626] Am J Ind Med. 2007 Nov;50(11):788-800 [17918215] Neurotoxicology. 2009 Nov;30(6):1207-13 [19393689] Neuromolecular Med. 2009;11(4):311-21 [20012385] Regul Toxicol Pharmacol. 2010 Jul-Aug;57(2-3):195-9 [20176068] Environ Res. 2011 Jan;111(1):156-63 [20943219] J Trace Elem Med Biol. 2012 Jun;26(2-3):179-82 [22664337] Neurotoxicology. 2012 Aug;33(4):697-702 [22285144] Neurotoxicology. 2012 Aug;33(4):687-96 [22322213] Environ Sci Pollut Res Int. 2013 Jul;20(7):5067-75 [23338992] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jes.2014.70 ER - TY - JOUR T1 - Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity. AN - 1689843159; 25964273 AB - The focus of this research was to develop a better understanding of the pertinent physico-chemical properties of silver nanoparticles (AgNPs) that affect genotoxicity, specifically how cellular uptake influences a genotoxic cell response. The genotoxicity of AgNPs was assessed for three potential mechanisms: mutagenicity, clastogenicity and DNA strand-break-based DNA damage. Mutagenicity (reverse mutation assay) was assessed in five bacterial strains of Salmonella typhimurium and Echerichia coli, including TA102 that is sensitive to oxidative DNA damage. AgNPs of all sizes tested (10, 20, 50 and 100nm), along with silver nitrate (AgNO3), were negative for mutagenicity in bacteria. No AgNPs could be identified within the bacteria cells using transmission electron microscopy (TEM), indicating these bacteria lack the ability to actively uptake AgNPs 10nm or larger. Clastogenicity (flow cytometry-based micronucleus assay) and intermediate DNA damage (DNA strand breaks as measured in the Comet assay) were assessed in two mammalian white blood cell lines: Jurkat Clone E6-1 and THP-1. It was observed that micronucleus and Comet assay end points were inversely correlated with AgNP size, with smaller NPs inducing a more genotoxic response. TEM results indicated that AgNPs were confined within intracellular vesicles of mammalian cells and did not penetrate the nucleus. The genotoxicity test results and the effect of AgNO3 controls suggest that silver ions may be the primary, and perhaps only, cause of genotoxicity. Furthermore, since AgNO3 was not mutagenic in the gram-negative bacterial Ames strains tested, the lack of bacterial uptake of the AgNPs may not be the major reason for the lack of genotoxicity observed. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society 2015. JF - Mutagenesis AU - Butler, Kimberly S AU - Peeler, David J AU - Casey, Brendan J AU - Dair, Benita J AU - Elespuru, Rosalie K AD - U.S. Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry, and Materials Science, 10933 New Hampshire Avenue, Silver Spring, MD 20993, USA. ; U.S. Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry, and Materials Science, 10933 New Hampshire Avenue, Silver Spring, MD 20993, USA Rosalie.Elespuru@fda.hhs.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 577 EP - 591 VL - 30 IS - 4 KW - Anti-Bacterial Agents KW - 0 KW - Mutagens KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - Comet Assay KW - Micronucleus Tests -- methods KW - Cell Survival -- genetics KW - Mutagenicity Tests -- methods KW - Escherichia coli Infections -- drug therapy KW - Humans KW - Jurkat Cells KW - DNA Repair -- drug effects KW - Microscopy, Electron, Transmission KW - Escherichia coli Infections -- microbiology KW - Cell Survival -- drug effects KW - Monocytes -- cytology KW - Cells, Cultured KW - Escherichia coli Infections -- genetics KW - Monocytes -- metabolism KW - Monocytes -- drug effects KW - Metal Nanoparticles -- administration & dosage KW - Salmonella typhimurium -- metabolism KW - Escherichia coli -- metabolism KW - Metal Nanoparticles -- chemistry KW - Anti-Bacterial Agents -- pharmacology KW - Escherichia coli -- genetics KW - Salmonella typhimurium -- drug effects KW - Mutagens -- pharmacology KW - DNA Damage -- genetics KW - DNA Damage -- drug effects KW - Silver -- chemistry KW - Escherichia coli -- drug effects KW - Salmonella typhimurium -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689843159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Silver+nanoparticles%3A+correlating+nanoparticle+size+and+cellular+uptake+with+genotoxicity.&rft.au=Butler%2C+Kimberly+S%3BPeeler%2C+David+J%3BCasey%2C+Brendan+J%3BDair%2C+Benita+J%3BElespuru%2C+Rosalie+K&rft.aulast=Butler&rft.aufirst=Kimberly&rft.date=2015-07-01&rft.volume=30&rft.issue=4&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgev020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-08 N1 - Date created - 2015-06-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Water Res. 2008 Jan;42(1-2):356-62 [17692890] Microbios. 2001;104(409):141-8 [11327108] J Biomed Mater Res. 2000 Dec 15;52(4):662-8 [11033548] Mutat Res Genet Toxicol Environ Mutagen. 2014 Jul 1;768:14-22 [24769488] Antimicrob Agents Chemother. 2002 Aug;46(8):2668-70 [12121953] Int J Antimicrob Agents. 2004 Mar;23 Suppl 1:S75-8 [15037331] Can J Microbiol. 1974 Jun;20(6):883-9 [4151872] Mutat Res. 1983 May;113(3-4):173-215 [6341825] Biometals. 1994 Jan;7(1):30-40 [8118170] Biochemistry. 1995 Jun 20;34(24):7896-903 [7794901] Ann Occup Hyg. 2005 Oct;49(7):575-85 [15964881] J Hosp Infect. 2006 Jan;62(1):58-63 [16099072] Toxicol Appl Pharmacol. 2008 Dec 15;233(3):404-10 [18930072] Mutat Res. 2009 Mar-Jun;681(2-3):241-58 [19041420] ACS Nano. 2009 Feb 24;3(2):279-90 [19236062] Toxicol Sci. 2009 Apr;108(2):452-61 [19033393] J Antimicrob Chemother. 2010 Feb;65(2):258-65 [19942617] Environ Sci Technol. 2010 Jul 15;44(14):5649-54 [20583805] Part Fibre Toxicol. 2010;7:20 [20691052] Nanotoxicology. 2010 Dec;4:409-13 [20925448] Nanotoxicology. 2010 Dec;4:414-20 [20925449] Antimicrob Agents Chemother. 2010 Dec;54(12):5120-31 [20855737] J Nanosci Nanotechnol. 2010 Dec;10(12):8456-62 [21121354] Biomaterials. 2011 Feb;32(5):1264-9 [21093906] Arch Toxicol. 2011 Jul;85(7):743-50 [20428844] Acta Biomater. 2011 Sep;7(9):3505-14 [21651999] Biomaterials. 2011 Dec;32(36):9810-7 [21944826] Mutat Res. 2011 Dec 24;726(2):129-35 [21945414] Toxicol Lett. 2012 Feb 5;208(3):286-92 [22101214] Toxicol Appl Pharmacol. 2012 Jan 1;258(1):89-98 [22036727] Environ Sci Technol. 2012 Jan 17;46(2):752-9 [22142034] Environ Sci Technol. 2012 Jan 17;46(2):1119-27 [22148238] Mutat Res. 2012 Feb 18;742(1-2):61-5 [22178963] Mutat Res. 2012 Jun 14;745(1-2):104-11 [21971291] Mutat Res. 2012 Jun 14;745(1-2):4-10 [22138422] Environ Mol Mutagen. 2012 Jul;53(6):409-19 [22576574] Nano Lett. 2012 Aug 8;12(8):4271-5 [22765771] Appl Environ Microbiol. 2007 Mar;73(6):1712-20 [17261510] Neurol Res. 2008 Apr;30(3):285-7 [17767809] Environ Sci Technol. 2008 Jun 15;42(12):4583-8 [18605590] J Phys Chem B. 2008 Oct 30;112(43):13608-19 [18831567] ACS Nano. 2012 Aug 28;6(8):7427-42 [22857815] Nanotechnology. 2012 Sep 21;23(37):375102 [22922335] Mutat Res. 2012 Dec 12;749(1-2):60-9 [22960309] J Appl Toxicol. 2013 Feb;33(2):78-89 [22936301] Toxicol Lett. 2013 Sep 12;222(1):55-63 [23872614] Crit Rev Microbiol. 2013 Nov;39(4):373-83 [22928774] Toxicology. 2013 Nov 8;313(1):38-48 [23142790] Adv Colloid Interface Sci. 2014 Feb;204:15-34 [24406050] Yonsei Med J. 2014 Mar;55(2):283-91 [24532494] Part Fibre Toxicol. 2014;11:11 [24529161] J Appl Toxicol. 2014 Nov;34(11):1155-66 [24522958] J Antimicrob Chemother. 2008 Apr;61(4):869-76 [18305203] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/gev020 ER - TY - JOUR T1 - The Effect of Cerium Oxide Nanoparticle Valence State on Reactive Oxygen Species and Toxicity. AN - 1689621827; 25778836 AB - Cerium oxide (CeO2) nanoparticles, which are used in a variety of products including solar cells, gas sensors, and catalysts, are expected to increase in industrial use. This will subsequently lead to additional occupational exposures, making toxicology screenings crucial. Previous toxicology studies have presented conflicting results as to the extent of CeO2 toxicity, which is hypothesized to be due to the ability of Ce to exist in both a +3 and +4 valence state. Thus, to study whether valence state and oxygen vacancy concentration are important in CeO2 toxicity, CeO2 nanoparticles were doped with gadolinium to adjust the cation (Ce, Gd) and anion (O) defect states. The hypothesis that doping would increase toxicity and decrease antioxidant abilities as a result of increased oxygen vacancies and inhibition of +3 to +4 transition was tested. Differences in toxicity and reactivity based on valence state were determined in RLE-6TN rat alveolar epithelial and NR8383 rat alveolar macrophage cells using enhanced dark field microscopy, electron paramagnetic resonance (EPR), and annexin V/propidium iodide cell viability stain. Results from EPR indicated that as doping increased, antioxidant potential decreased. Alternatively, doping had no effect on toxicity at 24 h. The present results imply that as doping increases, thus subsequently increasing the Ce(3+)/Ce(4+) ratio, antioxidant potential decreases, suggesting that differences in reactivity of CeO2 are due to the ability of Ce to transition between the two valence states and the presence of increased oxygen vacancies, rather than dependent on a specific valence state. JF - Biological trace element research AU - Dunnick, Katherine M AU - Pillai, Rajalekshmi AU - Pisane, Kelly L AU - Stefaniak, Aleksandr B AU - Sabolsky, Edward M AU - Leonard, Stephen S AD - National Institute for Occupational Safety and Health, HELD, 1095 Willowdale Rd, Morgantown, WV, 26505, USA, kdunnick@mix.wvu.edu. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 96 EP - 107 VL - 166 IS - 1 KW - Antioxidants KW - 0 KW - Environmental Pollutants KW - Reactive Oxygen Species KW - Cerium KW - 30K4522N6T KW - gadolinium oxide KW - 5480D0NHLJ KW - ceric oxide KW - 619G5K328Y KW - Gadolinium KW - AU0V1LM3JT KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Cell Culture Techniques KW - Gadolinium -- chemistry KW - Macrophages, Alveolar -- drug effects KW - Structure-Activity Relationship KW - Epithelial Cells -- metabolism KW - Macrophages, Alveolar -- metabolism KW - Rats KW - Antioxidants -- metabolism KW - Epithelial Cells -- drug effects KW - Oxygen -- chemistry KW - Cell Line KW - Surface Properties KW - Reactive Oxygen Species -- metabolism KW - Environmental Pollutants -- toxicity KW - Environmental Pollutants -- chemistry KW - Cerium -- chemistry KW - Cerium -- toxicity KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689621827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+trace+element+research&rft.atitle=The+Effect+of+Cerium+Oxide+Nanoparticle+Valence+State+on+Reactive+Oxygen+Species+and+Toxicity.&rft.au=Dunnick%2C+Katherine+M%3BPillai%2C+Rajalekshmi%3BPisane%2C+Kelly+L%3BStefaniak%2C+Aleksandr+B%3BSabolsky%2C+Edward+M%3BLeonard%2C+Stephen+S&rft.aulast=Dunnick&rft.aufirst=Katherine&rft.date=2015-07-01&rft.volume=166&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Biological+trace+element+research&rft.issn=1559-0720&rft_id=info:doi/10.1007%2Fs12011-015-0297-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-17 N1 - Date created - 2015-06-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Toxicol Environ Health A. 2014;77(20):1251-68 [25208664] J Immunol. 2002 Oct 15;169(8):4531-41 [12370390] Biomaterials. 2007 Apr;28(10):1918-25 [17222903] Chem Commun (Camb). 2007 Mar 14;(10):1056-8 [17325804] Toxicology. 2008 Mar 12;245(1-2):90-100 [18243471] ACS Nano. 2008 Oct 28;2(10):2121-34 [19206459] Toxicol Lett. 2009 Jun 1;187(2):77-83 [19429248] Nanomedicine. 2010 Oct;6(5):698-705 [20172051] Part Fibre Toxicol. 2010;7:32 [21047424] Part Fibre Toxicol. 2011;8(1):2 [21247485] Crit Rev Toxicol. 2011 Mar;41(3):213-29 [21244219] ACS Nano. 2011 Jun 28;5(6):4537-49 [21612305] Toxicol Lett. 2011 Aug 28;205(2):105-15 [21624445] Toxicol Appl Pharmacol. 2012 Aug 1;262(3):255-64 [22613087] Toxicol In Vitro. 2013 Apr;27(3):1082-8 [23416263] Nanotoxicology. 2013 Dec;7(8):1338-50 [23061914] Cardiovasc Toxicol. 2013 Dec;13(4):323-37 [23645470] Environ Health Perspect. 1996 Mar;104 Suppl 1:85-95 [8722113] Int J Toxicol. 2006 Nov-Dec;25(6):451-7 [17132603] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s12011-015-0297-4 ER - TY - JOUR T1 - Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations. AN - 1687361575; 25549947 AB - Breast cancer incidence continues to increase in the US and Europe, a reflection of the growing influence of environment factors that interact with personal genetics. The US Environmental Protection Agency estimates that there are approximately 10,000 endocrine disrupting chemicals among the common daily exposures that could affect the risk of disease. The daunting tasks of identifying, characterizing, and elucidating the mechanisms of endocrine disrupting chemicals in breast cancer need to be addressed to produce a comprehensive model that will facilitate preventive strategies and public policy. An expert panel met to describe and bring attention to needs linking common environmental exposures, critical windows of exposure, and optimal times of assessment in investigating breast cancer risk. The group included investigators with extensive experience in the use of rodent models and in leading population studies and produced a set of recommendations for effective approaches to gaining insights into the environmental origins of breast cancer across the lifespan. Published by Elsevier Inc. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Teitelbaum, Susan L AU - Belpoggi, Fiorella AU - Reinlib, Les AD - Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bentivoglio, Bologna, Italy. ; National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address: reinlib@niehs.nih.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 141 EP - 147 VL - 54 KW - Carcinogens, Environmental KW - 0 KW - Endocrine Disruptors KW - Index Medicus KW - Endocrine disrupting chemicals KW - Windows of susceptibility KW - Mammary gland biology KW - Breast cancer KW - Sexual Development KW - Animals KW - Age Factors KW - Cell Transformation, Neoplastic -- pathology KW - Disease Susceptibility KW - Risk Factors KW - Humans KW - Cell Transformation, Neoplastic -- metabolism KW - Cell Transformation, Neoplastic -- chemically induced KW - Environmental Exposure -- adverse effects KW - Time Factors KW - Female KW - Risk Assessment KW - Mammary Glands, Animal -- drug effects KW - Mammary Glands, Human -- metabolism KW - Breast Neoplasms -- metabolism KW - Mammary Glands, Animal -- growth & development KW - Carcinogens, Environmental -- toxicity KW - Research Design KW - Endocrine Disruptors -- toxicity KW - Breast Neoplasms -- pathology KW - Biomedical Research -- methods KW - Mammary Glands, Animal -- metabolism KW - Mammary Glands, Animal -- pathology KW - Mammary Glands, Human -- pathology KW - Mammary Glands, Human -- growth & development KW - Breast Neoplasms -- chemically induced KW - Mammary Glands, Human -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687361575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Advancing+research+on+endocrine+disrupting+chemicals+in+breast+cancer%3A+Expert+panel+recommendations.&rft.au=Teitelbaum%2C+Susan+L%3BBelpoggi%2C+Fiorella%3BReinlib%2C+Les&rft.aulast=Teitelbaum&rft.aufirst=Susan&rft.date=2015-07-01&rft.volume=54&rft.issue=&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=1873-1708&rft_id=info:doi/10.1016%2Fj.reprotox.2014.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-04 N1 - Date created - 2015-06-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Hum Reprod. 2014 Jul;29(7):1558-66 [24781428] Environ Health Perspect. 2013 Sep;121(9):1040-6 [23876597] Int J Circumpolar Health. 2014;73:25760 [25442219] Reprod Toxicol. 2015 Jul;54:129-35 [25463529] J Epidemiol Biostat. 1999;4(3):191-210; discussion 210-5 [10695959] Environ Health Perspect. 2000 Jun;108 Suppl 3:451-5 [10852844] Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] J Natl Cancer Inst. 2001 Jan 3;93(1):60-2 [11136844] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1509-14 [16896041] BMC Genomics. 2007;8:453 [18062813] J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):276-300 [18368557] Br J Cancer. 2008 May 6;98(9):1485-93 [18392054] Curr Stem Cell Res Ther. 2009 Jan;4(1):50-60 [19149630] Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2447-52 [19690178] Environ Health Perspect. 2010 Apr;118(4):539-44 [20368132] Environ Health Perspect. 2010 May;118(5):596-601 [20435547] Cancer Causes Control. 2010 Jul;21(7):999-1007 [20204493] Nat Rev Endocrinol. 2010 Jul;6(7):363-70 [20498677] Environ Health. 2011;10(1):5 [21241498] Environ Health Perspect. 2010 Nov;118(11):1614-9 [20675265] Toxicol Appl Pharmacol. 2011 Jul 15;254(2):181-91 [21034758] Toxicol Sci. 2011 Jul;122(1):134-45 [21482639] Br J Cancer. 2011 Aug 23;105(5):709-22 [21772329] Nat Med. 2011 Sep;17(9):1109-15 [21822285] J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):16-26 [21397692] Chemosphere. 2011 Dec;85(11):1701-6 [22014662] Environ Health Perspect. 2011 Dec;119(12):1700-5 [21810551] Endocrinology. 2012 Jan;153(1):42-55 [22109888] FASEB J. 2012 Feb;26(2):778-87 [22049059] Eur J Epidemiol. 2012 Jan;27(1):1-3 [22286719] Int J Androl. 2012 Jun;35(3):216-26 [22428786] Reprod Toxicol. 2012 Jul;33(4):563-76 [22414604] Int J Mol Sci. 2012;13(8):10143-53 [22949852] Environ Health Perspect. 2012 Oct;120(10):1432-7 [22935244] Environ Health Perspect. 2012 Nov;120(11):1613-8 [23124194] J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):25-42 [23392570] J Adolesc Health. 2013 May;52(5 Suppl):S15-20 [23601607] ILAR J. 2012;53(3-4):289-305 [23744968] Breast J. 2001 Sep-Oct;7(5):278-91 [11906437] Environ Health Perspect. 2002 Jul;110(7):625-8 [12117637] Nature. 2003 May 29;423(6939):545-50 [12774124] Radiat Res. 2003 Dec;160(6):707-17 [14640793] Trends Endocrinol Metab. 2004 Jul;15(5):193-7 [15223047] Lancet. 1989 Sep 9;2(8663):577-80 [2570282] IARC Sci Publ. 1991;(112):3-23 [1855946] J Endocrinol. 1997 Mar;152(3):477-87 [9071969] J Anat. 1953 Oct;87(4):387-406 [13117757] J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):199-208 [23702822] Toxicol Sci. 2014 Jan;137(1):1-2 [24213143] Sci Rep. 2014;4:5664 [25012808] Climacteric. 2014 Aug;17(4):377-84 [24228746] J Expo Sci Environ Epidemiol. 2013 Jul;23(4):343-9 [22781437] Nutrition. 2005 Jun;21(6):775-7 [15925305] Birth Defects Res C Embryo Today. 2013 Jun;99(2):134-46 [23897597] J Clin Endocrinol Metab. 2014 Oct;99(10):3829-35 [25029416] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.reprotox.2014.12.015 ER - TY - JOUR T1 - Demographic characteristics and food choices of participants in the special diabetes program for American Indians diabetes prevention demonstration project AN - 1686418503; 4677187 AB - Objective. American Indians and Alaska Natives (AI/ANs) suffer a disproportionate burden of diabetes. Identifying food choices of AI/ANs at risk of type 2 diabetes, living in both rural and urban settings, is critical to the development of culturally relevant, evidence-based education strategies designed to reduce morbidity and mortality in this population. Reprinted by permission of Taylor & Francis Ltd. JF - Ethnicity and health AU - Teufel-Shone, Nicolette I AU - Jiang, Luohua AU - Beals, Janette AU - Henderson, William G AU - Zhang, Lijing AU - Acton, Kelly J AU - Roubideaux, Yvette AU - Manson, Spero M AD - University of Arizona ; Texas A&M University ; University of Colorado, Denver ; Indian Health Service Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 327 EP - 340 VL - 20 IS - 4 SN - 1355-7858, 1355-7858 KW - Sociology KW - Cultural development KW - Risk KW - Mortality KW - Education KW - U.S.A. KW - Morbidity KW - Diabetes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686418503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+and+health&rft.atitle=Demographic+characteristics+and+food+choices+of+participants+in+the+special+diabetes+program+for+American+Indians+diabetes+prevention+demonstration+project&rft.au=Teufel-Shone%2C+Nicolette+I%3BJiang%2C+Luohua%3BBeals%2C+Janette%3BHenderson%2C+William+G%3BZhang%2C+Lijing%3BActon%2C+Kelly+J%3BRoubideaux%2C+Yvette%3BManson%2C+Spero+M&rft.aulast=Teufel-Shone&rft.aufirst=Nicolette&rft.date=2015-07-01&rft.volume=20&rft.issue=4&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Ethnicity+and+health&rft.issn=13557858&rft_id=info:doi/10.1080%2F13557858.2014.921890 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-06-08 N1 - Last updated - 2015-06-08 N1 - SubjectsTermNotLitGenreText - 3524 6220; 4049; 8291 3409 6306; 3119 3105 3198 3483; 11035; 8285 3409 6306; 433 293 14 DO - http://dx.doi.org/10.1080/13557858.2014.921890 ER - TY - JOUR T1 - Safety of octreotide in hospitalized infants. AN - 1684433252; 25968047 AB - Octreotide is used off-label in infants for treatment of chylothorax, congenital hyperinsulinism, and gastrointestinal bleeding. The safety profile of octreotide in hospitalized infants has not been described; we sought to fill this information gap. We identified all infants exposed to at least 1 dose of octreotide from a cohort of 887,855 infants discharged from 333 neonatal intensive care units managed by the Pediatrix Medical Group between 1997 and 2012. We collected laboratory and clinical information while infants were exposed to octreotide and described the frequency of baseline diagnoses, laboratory abnormalities, and clinical adverse events (AEs). A total of 428 infants received 490 courses of octreotide. The diagnoses most commonly associated with octreotide use were chylothorax (50%), pleural effusion (32%), and hypoglycemia (22%). The most common laboratory AEs that occurred during exposure to octreotide were thrombocytopenia (47/1000 infant-days), hyperkalemia (21/1000 infant-days), and leukocytosis (20/1000 infant-days). Hyperglycemia occurred in 1/1000 infant-days and hypoglycemia in 3/1000 infant-days. Hypotension requiring pressors (12%) was the most common clinical AE that occurred during exposure to octreotide. Necrotizing enterocolitis was observed in 9/490 (2%) courses, and death occurred in 11 (3%) infants during octreotide administration. Relatively few AEs occurred during off-label use of octreotide in this cohort of infants. Additional studies are needed to further evaluate the safety, dosing, and efficacy of this medication in infants. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Early human development AU - Testoni, Daniela AU - Hornik, Christoph P AU - Neely, Megan L AU - Yang, Qinghong AU - McMahon, Ann W AU - Clark, Reese H AU - Smith, P Brian AU - Best Pharmaceuticals for Children Act — Pediatric Trials Network Administrative Core Committee AD - Duke Clinical Research Institute, Durham, NC, United States; Division of Neonatal Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. ; Duke Clinical Research Institute, Durham, NC, United States; Department of Pediatrics, Duke University, Durham, NC, United States. ; Duke Clinical Research Institute, Durham, NC, United States; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, United States. ; Duke Clinical Research Institute, Durham, NC, United States. ; Office of Pediatric Therapeutics, Food and Drug Administration, Silver Spring, MD, United States. ; Pediatrix-Obstetrix Center for Research and Education, Sunrise, FL, United States. ; Duke Clinical Research Institute, Durham, NC, United States; Department of Pediatrics, Duke University, Durham, NC, United States. Electronic address: brian.smith@duke.edu. ; Best Pharmaceuticals for Children Act — Pediatric Trials Network Administrative Core Committee Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 387 EP - 392 VL - 91 IS - 7 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Octreotide KW - RWM8CCW8GP KW - Index Medicus KW - Infant KW - Drug toxicity KW - Safety KW - Off-Label Use KW - Hospitalization KW - Humans KW - Infant, Newborn KW - Chylothorax -- drug therapy KW - Pleural Effusion -- drug therapy KW - Intensive Care Units, Neonatal KW - Hypoglycemia -- drug therapy KW - Male KW - Female KW - Hypotension -- chemically induced KW - Octreotide -- therapeutic use KW - Octreotide -- adverse effects KW - Thrombocytopenia -- chemically induced KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Antineoplastic Agents, Hormonal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684433252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Early+human+development&rft.atitle=Safety+of+octreotide+in+hospitalized+infants.&rft.au=Testoni%2C+Daniela%3BHornik%2C+Christoph+P%3BNeely%2C+Megan+L%3BYang%2C+Qinghong%3BMcMahon%2C+Ann+W%3BClark%2C+Reese+H%3BSmith%2C+P+Brian%3BBest+Pharmaceuticals+for+Children+Act+%E2%80%94+Pediatric+Trials+Network+Administrative+Core+Committee&rft.aulast=Testoni&rft.aufirst=Daniela&rft.date=2015-07-01&rft.volume=91&rft.issue=7&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Early+human+development&rft.issn=1872-6232&rft_id=info:doi/10.1016%2Fj.earlhumdev.2015.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-23 N1 - Date created - 2015-05-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Saudi J Gastroenterol. 2012 Mar-Apr;18(2):87-94 [22421712] Eur Respir J. 2012 Mar;39(3):772-5 [22379151] PLoS One. 2012;7(5):e36411 [22574156] J Pediatr Surg. 2013 Mar;48(3):568-72 [23480914] Gastroenterology. 2003 May;124(5):1277-91 [12730868] Pediatr Crit Care Med. 2006 May;7(3):245-8 [16575348] J Pediatr Surg. 2008 Jun;43(6):1209-10 [18558210] Pediatr Blood Cancer. 2008 Dec;51(6):824-5 [18726919] Eur J Cancer. 2009 Jul;45(10):1788-97 [19303768] Life Sci. 1982 Sep 13;31(11):1133-40 [6128648] J Clin Endocrinol Metab. 1985 Jun;60(6):1161-5 [2860119] Am J Surg. 1991 Jan;161(1):177-82; discussion 182-3 [1987853] Arch Dis Child. 1992 Apr;67(4 Spec No):432-5 [1586186] Gut. 1996 May;38(5):775-83 [8707128] Aliment Pharmacol Ther. 1998 Mar;12(3):237-45 [9570258] Pediatr Cardiol. 2005 Jul-Aug;26(4):440-3 [16374694] J Clin Oncol. 2009 Oct 1;27(28):4656-63 [19704057] Rev Port Cardiol. 2009 Jul-Aug;28(7-8):799-807 [19894659] Pediatr Nephrol. 2010 Feb;25(2):363-6 [19902268] Pediatr Diabetes. 2010 Mar;11(2):142-7 [19558634] Eur J Pediatr. 2000 Jul;159(7):550 [10923237] Ann Hematol. 2013 Jul;92(7):961-7 [23519382] J Pediatr Gastroenterol Nutr. 2004 Jan;38(1):41-7 [14676593] J Perinatol. 2004 Mar;24(3):194-5 [15044931] Pediatr Crit Care Med. 2004 Jul;5(4):356-7 [15215005] Acta Chir Scand. 1979;145(7):443-46 [161458] Arq Bras Endocrinol Metabol. 2005 Jun;49(3):460-7 [16544003] Intensive Care Med. 2006 May;32(5):650-7 [16532329] J Pediatr Gastroenterol Nutr. 2010 Oct;51(4):454-7 [20512058] Fed Regist. 2010 Sep 29;75(188):59935-63 [20879180] Congenit Heart Dis. 2010 Nov-Dec;5(6):573-8 [21106017] Pediatr Blood Cancer. 2011 Jan;56(1):45-9 [21108438] Adv Neonatal Care. 2011 Jun;11(3):155-64; quiz 165-6 [21730907] Arq Bras Cardiol. 2011 Aug;97(2):e33-6 [22002034] Pediatr Neonatol. 2011 Oct;52(5):297-301 [22036228] Eur J Endocrinol. 2012 Feb;166(2):333-9 [22048969] J Perinatol. 2012 Mar;32(3):199-204 [21593813] Br J Haematol. 2012 May;157(3):381-2 [22145577] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.earlhumdev.2015.04.008 ER - TY - JOUR T1 - Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats. AN - 1684432957; 25862956 AB - Bisphenol A (BPA), an industrial chemical used in the manufacture of polycarbonate and epoxy resins, binds to the nuclear estrogen receptor with an affinity 4-5 orders of magnitude lower than that of estradiol. We reported previously that "high BPA" [100,000 and 300,000 µg/kg body weight (bw)/day], but not "low BPA" (2.5-2700 µg/kg bw/day), induced clear adverse effects in NCTR Sprague-Dawley rats gavaged daily from gestation day 6 through postnatal day (PND) 90. The "high BPA" effects partially overlapped those of ethinyl estradiol (EE2, 0.5 and 5.0 µg/kg bw/day). To evaluate further the potential of "low BPA" to induce biological effects, here we assessed the global genomic DNA methylation and gene expression in the prostate and female mammary glands, tissues identified previously as potential targets of BPA, and uterus, a sensitive estrogen-responsive tissue. Both doses of EE2 modulated gene expression, including of known estrogen-responsive genes, and PND 4 global gene expression data showed a partial overlap of the "high BPA" effects with those of EE2. The "low BPA" doses modulated the expression of several genes; however, the absence of a dose response reduces the likelihood that these changes were causally linked to the treatment. These results are consistent with the toxicity outcomes. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Camacho, Luísa AU - Basavarajappa, Mallikarjuna S AU - Chang, Ching-Wei AU - Han, Tao AU - Kobets, Tetyana AU - Koturbash, Igor AU - Surratt, Gordon AU - Lewis, Sherry M AU - Vanlandingham, Michelle M AU - Fuscoe, James C AU - Gamboa da Costa, Gonçalo AU - Pogribny, Igor P AU - Delclos, K Barry AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: luisa.camacho@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Office of Scientific Coordination, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 92 EP - 103 VL - 81 KW - Benzhydryl Compounds KW - 0 KW - Complement C3 KW - Phenols KW - Receptors, Estrogen KW - Receptors, Progesterone KW - S100 Calcium Binding Protein G KW - Vascular Endothelial Growth Factor A KW - vascular endothelial growth factor A, rat KW - Ethinyl Estradiol KW - 423D2T571U KW - Methyltransferases KW - EC 2.1.1.- KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Bisphenol A KW - Microarray KW - Ethinyl estradiol KW - Mammary gland KW - Prostate KW - Global genomic DNA methylation KW - Animals KW - Gene Expression KW - Ethinyl Estradiol -- toxicity KW - Rats KW - Receptors, Progesterone -- metabolism KW - Methyltransferases -- metabolism KW - Ethinyl Estradiol -- administration & dosage KW - Male KW - Administration, Oral KW - Genomics -- methods KW - Dose-Response Relationship, Drug KW - Complement C3 -- genetics KW - Tandem Mass Spectrometry KW - Receptors, Estrogen -- metabolism KW - Complement C3 -- metabolism KW - Protein Binding KW - Pregnancy KW - Prenatal Exposure Delayed Effects -- pathology KW - Receptors, Progesterone -- genetics KW - Rats, Sprague-Dawley KW - Receptors, Estrogen -- genetics KW - Chromatography, Liquid KW - S100 Calcium Binding Protein G -- genetics KW - S100 Calcium Binding Protein G -- metabolism KW - Vascular Endothelial Growth Factor A -- genetics KW - Female KW - Vascular Endothelial Growth Factor A -- metabolism KW - Uterus -- metabolism KW - Prostate -- drug effects KW - Phenols -- administration & dosage KW - Benzhydryl Compounds -- toxicity KW - Mammary Glands, Animal -- drug effects KW - Mammary Glands, Animal -- metabolism KW - DNA Methylation -- drug effects KW - Prostate -- metabolism KW - Phenols -- toxicity KW - Uterus -- drug effects KW - Benzhydryl Compounds -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684432957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Effects+of+oral+exposure+to+bisphenol+A+on+gene+expression+and+global+genomic+DNA+methylation+in+the+prostate%2C+female+mammary+gland%2C+and+uterus+of+NCTR+Sprague-Dawley+rats.&rft.au=Camacho%2C+Lu%C3%ADsa%3BBasavarajappa%2C+Mallikarjuna+S%3BChang%2C+Ching-Wei%3BHan%2C+Tao%3BKobets%2C+Tetyana%3BKoturbash%2C+Igor%3BSurratt%2C+Gordon%3BLewis%2C+Sherry+M%3BVanlandingham%2C+Michelle+M%3BFuscoe%2C+James+C%3BGamboa+da+Costa%2C+Gon%C3%A7alo%3BPogribny%2C+Igor+P%3BDelclos%2C+K+Barry&rft.aulast=Camacho&rft.aufirst=Lu%C3%ADsa&rft.date=2015-07-01&rft.volume=81&rft.issue=&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-01 N1 - Date created - 2015-05-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neurobiol Aging. 2009 Jun;30(6):932-45 [17950954] NTP CERHR MON. 2008 Sep;(22):v, vii-ix, 1-64 passim [19407859] Methods Mol Biol. 2009;563:379-98 [19597796] Biol Reprod. 2010 Jan;82(1):86-95 [19696011] BMC Bioinformatics. 2006;7 Suppl 2:S23 [17118145] FASEB J. 2010 Jul;24(7):2273-80 [20181937] Toxicol Appl Pharmacol. 2010 Sep 1;247(2):158-65 [20600215] Natl Toxicol Program Tech Rep Ser. 2010 Aug;(547):1-312 [21031005] Endocrinology. 2012 Jan;153(1):42-55 [22109888] Int J Environ Res Public Health. 2012 Mar;9(3):698-711 [22690157] J Physiol Pharmacol. 2012 Oct;63(5):445-55 [23211298] J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):43-61 [23417729] Int J Oncol. 2013 May;42(5):1822-32 [23483119] PLoS One. 2013;8(5):e63902 [23704952] Nat Protoc. 2013 Aug;8(8):1551-66 [23868073] Reprod Toxicol. 2013 Sep;40:35-40 [23747832] Endocrine. 2013 Dec;44(3):773-83 [23494413] BMC Genomics. 2014;15:30 [24433282] Endocrinology. 2014 Mar;155(3):805-17 [24424067] Int J Impot Res. 2014 Mar-Apr;26(2):67-75 [24305612] Toxicol Sci. 2014 May;139(1):4-20 [24496641] Toxicol Sci. 2014 Jul;140(1):190-203 [24752507] PLoS One. 2014;9(7):e99800 [24988533] Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9956-61 [23716699] J Steroid Biochem Mol Biol. 2000 May;73(1-2):1-10 [10822019] Methods. 2001 Dec;25(4):402-8 [11846609] Steroids. 2002 Mar;67(3-4):305-10 [11856554] J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70 [11867264] Mol Cell Endocrinol. 2002 Jun 14;191(2):177-86 [12062901] Toxicol Sci. 2002 Jul;68(1):121-46 [12075117] J Endocrinol. 2004 Apr;181(1):157-67 [15072576] Biol Reprod. 1991 Aug;45(2):308-21 [1786296] Toxicol Appl Pharmacol. 1992 Feb;112(2):300-9 [1539166] Endocrinology. 1994 Jan;134(1):432-40 [8275956] Endocrinology. 1998 Oct;139(10):4252-63 [9751507] Mol Cell Endocrinol. 1998 Jul 25;142(1-2):203-14 [9783916] Biochem Biophys Res Commun. 1999 Sep 7;262(3):624-8 [10471374] BMC Mol Biol. 2006;7:3 [16448564] Cancer Res. 2006 Jun 1;66(11):5624-32 [16740699] Crit Rev Toxicol. 2006 May;36(5):387-457 [16954066] J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):175-9 [17088055] Toxicol Lett. 2006 Dec 1;167(2):95-105 [17049190] Arch Toxicol. 2006 Dec;80(12):839-45 [16639590] Toxicol Sci. 2007 Sep;99(1):303-14 [17557909] Reprod Toxicol. 2007 Aug-Sep;24(2):199-224 [17683900] J Endocrinol. 2008 Jan;196(1):101-12 [18180321] Environ Health Perspect. 2008 Jan;116(1):39-44 [18197297] Neoplasia. 2008 Jan;10(1):20-40 [18231636] Toxicol Sci. 2008 Aug;104(2):362-84 [18445619] Endocrinology. 2008 Nov;149(11):5366-73 [18669594] Natl Toxicol Program Tech Rep Ser. 2010 Jul;(548):1-210 [21031006] Toxicol Lett. 2010 Dec 15;199(3):372-6 [20933065] Clin Chem Lab Med. 2010 Dec;48(12):1793-8 [20979561] Environ Health Perspect. 2011 Jan;119(1):104-12 [20870566] J Expo Sci Environ Epidemiol. 2011 May-Jun;21(3):272-9 [20237498] J Nutr. 2011 Sep;141(9):1583-9 [21753063] Toxicol Lett. 2011 Oct 10;206(2):166-71 [21784140] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.04.009 ER - TY - JOUR T1 - Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. AN - 1698962220; 26109056 AB - Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for transcriptome-based applications beyond the limitations of microarrays, we sought to systematically evaluate the performance of RNA-seq-based and microarray-based classifiers in this MAQC-III/SEQC study for clinical endpoint prediction using neuroblastoma as a model. We generate gene expression profiles from 498 primary neuroblastomas using both RNA-seq and 44 k microarrays. Characterization of the neuroblastoma transcriptome by RNA-seq reveals that more than 48,000 genes and 200,000 transcripts are being expressed in this malignancy. We also find that RNA-seq provides much more detailed information on specific transcript expression patterns in clinico-genetic neuroblastoma subgroups than microarrays. To systematically compare the power of RNA-seq and microarray-based models in predicting clinical endpoints, we divide the cohort randomly into training and validation sets and develop 360 predictive models on six clinical endpoints of varying predictability. Evaluation of factors potentially affecting model performances reveals that prediction accuracies are most strongly influenced by the nature of the clinical endpoint, whereas technological platforms (RNA-seq vs. microarrays), RNA-seq data analysis pipelines, and feature levels (gene vs. transcript vs. exon-junction level) do not significantly affect performances of the models. We demonstrate that RNA-seq outperforms microarrays in determining the transcriptomic characteristics of cancer, while RNA-seq and microarray-based models perform similarly in clinical endpoint prediction. Our findings may be valuable to guide future studies on the development of gene expression-based predictive models and their implementation in clinical practice. JF - Genome biology AU - Zhang, Wenqian AU - Yu, Ying AU - Hertwig, Falk AU - Thierry-Mieg, Jean AU - Zhang, Wenwei AU - Thierry-Mieg, Danielle AU - Wang, Jian AU - Furlanello, Cesare AU - Devanarayan, Viswanath AU - Cheng, Jie AU - Deng, Youping AU - Hero, Barbara AU - Hong, Huixiao AU - Jia, Meiwen AU - Li, Li AU - Lin, Simon M AU - Nikolsky, Yuri AU - Oberthuer, André AU - Qing, Tao AU - Su, Zhenqiang AU - Volland, Ruth AU - Wang, Charles AU - Wang, May D AU - Ai, Junmei AU - Albanese, Davide AU - Asgharzadeh, Shahab AU - Avigad, Smadar AU - Bao, Wenjun AU - Bessarabova, Marina AU - Brilliant, Murray H AU - Brors, Benedikt AU - Chierici, Marco AU - Chu, Tzu-Ming AU - Zhang, Jibin AU - Grundy, Richard G AU - He, Min Max AU - Hebbring, Scott AU - Kaufman, Howard L AU - Lababidi, Samir AU - Lancashire, Lee J AU - Li, Yan AU - Lu, Xin X AU - Luo, Heng AU - Ma, Xiwen AU - Ning, Baitang AU - Noguera, Rosa AU - Peifer, Martin AU - Phan, John H AU - Roels, Frederik AU - Rosswog, Carolina AU - Shao, Susan AU - Shen, Jie AU - Theissen, Jessica AU - Tonini, Gian Paolo AU - Vandesompele, Jo AU - Wu, Po-Yen AU - Xiao, Wenzhong AU - Xu, Joshua AU - Xu, Weihong AU - Xuan, Jiekun AU - Yang, Yong AU - Ye, Zhan AU - Dong, Zirui AU - Zhang, Ke K AU - Yin, Ye AU - Zhao, Chen AU - Zheng, Yuanting AU - Wolfinger, Russell D AU - Shi, Tieliu AU - Malkas, Linda H AU - Berthold, Frank AU - Wang, Jun AU - Tong, Weida AU - Shi, Leming AU - Peng, Zhiyu AU - Fischer, Matthias AD - BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Yantian District, Shenzhen, Guangdong, 518083, China. ; Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, 201203, China. ; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Kerpener Strasse 62, D-50924, Cologne, Germany. ; NIH/NCBI, Bldg 38A/Room 8S808, 8600 Rockville Pike, Bethesda, MD, 20894, USA. ; Eli Lilly and Company Research Informatics, Lilly Corporate Center, Drop Code 0725, Indianapolis, IN, 46285, USA. ; Fondazione Bruno Kessler (FBK), Via Sommarive 18, 38123, Trento Povo, TN, Italy. ; AbbVie Inc., Global Pharmaceutical R&D, 32 Knights Crest Court, Souderton, PA, 18964, USA. ; GlaxoSmithKline, Discovery Analytics, Mailstop UP4335, 1250 South Collegeville Rd, Collegeville, PA, 19426, USA. ; Department of Internal Medicine, Rush University Cancer Center, 1725 W. Harrison Street, Chicago, IL, 60612, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. ; SAS Institute Inc., SAS Campus Drive, Cary, NC, 27513, USA. ; Marshfield Clinic Research Foundation, Biomedical Informatics Research Center, 1000 N Oak Avenue, Marshfield, WI, 54449, USA. ; Thomson Reuters IP & Science, 5901 Priesty Drive, Carlsbad, CA, 92008, USA. ; Center for Genomics and Division of Microbiology & Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA. ; Department of Biomedical Engineering, GeorgiaTech and Emory University, 313 Ferst Drive, Atlanta, GA, 30332, USA. ; Fondazione Edmund Mach, CRI-CBC, San Michele all'Adige, TN, Italy. ; Children's Hospital Los Angeles, Los Angeles, CA, 90027, USA. ; Department of Pediatric Hematology-Oncology, Molecular Oncology, Felsenstein Medical Research Center, Schneider Children's Medical Center of Israel, Petach Tikva, 49202, Israel. ; Marshfield Clinic Research Foundation, Center of Human Genetics, 1000 N Oak Avenue, Marshfield, WI, 54449, USA. ; Department of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany. ; University of Nottingham, Children's Brain Tumour Research Centre, Queen's Medical Centre, University of Nottingham, D Floor Medical School, Nottingham, NG7 2UH, UK. ; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, WOC1 RM400S, HFM-210, 1401 Rockville Pike, Rockville, MD, 20852, USA. ; AbbVie Inc., Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL, 60064, USA. ; Eli Lilly and Company, Discovery Statistics, Lilly Corporate Center, Drop Code 2036, Indianapolis, IN, 46285, USA. ; Department of Pathology, University of Valencia, Medical School, Avda. Blasco Ibáñez, 17, 46010, Valencia, Spain. ; University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Kerpener Strasse 62, D-50924, Cologne, Germany. ; Neuroblastoma Laboratory, Onco/Hematology Laboratory, SDB Department, University of Padua, Pediatric Research Institute, Padua, Italy. ; Department of Pediatrics and Genetics, Ghent University, Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium. ; Georgia Institute of Technology, School of Electrical and Computer Engineering, 777 Atlantic Drive NW, Atlanta, GA, 30332, USA. ; Harvard Medical School, Massachusetts General Hospital, 51 Blossom Street, Boston, MA, 02114, USA. ; Stanford University, Stanford Genome Technology Center, 855 South California Avenue, Palo Alto, CA, 94304, USA. ; Department of Pathology, University of North Dakota School of Medicine, 501 N. Columbia Road RM 3573, Grand Forks, ND, 58202-9037, USA. ; East China Normal University, Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, the Institute of Biomedical Sciences and School of Life Sciences, 500 Dongchuan Road, Shanghai, 200241, China. ; Department of Molecular & Cellular Biology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA. ; Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, 201203, China. lemingshi@fudan.edu.cn. ; BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Yantian District, Shenzhen, Guangdong, 518083, China. pengzhiyu@genomics.org.cn. ; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Kerpener Strasse 62, D-50924, Cologne, Germany. matthias.fischer@uk-koeln.de. Y1 - 2015/06/25/ PY - 2015 DA - 2015 Jun 25 SP - 133 VL - 16 KW - Index Medicus KW - Infant KW - Young Adult KW - Tumor Cells, Cultured KW - Endpoint Determination KW - Models, Genetic KW - Humans KW - Adult KW - Infant, Newborn KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Gene Expression Profiling KW - Neuroblastoma -- genetics KW - Neuroblastoma -- diagnosis KW - Oligonucleotide Array Sequence Analysis KW - Sequence Analysis, RNA KW - Neuroblastoma -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698962220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+biology&rft.atitle=Comparison+of+RNA-seq+and+microarray-based+models+for+clinical+endpoint+prediction.&rft.au=Zhang%2C+Wenqian%3BYu%2C+Ying%3BHertwig%2C+Falk%3BThierry-Mieg%2C+Jean%3BZhang%2C+Wenwei%3BThierry-Mieg%2C+Danielle%3BWang%2C+Jian%3BFurlanello%2C+Cesare%3BDevanarayan%2C+Viswanath%3BCheng%2C+Jie%3BDeng%2C+Youping%3BHero%2C+Barbara%3BHong%2C+Huixiao%3BJia%2C+Meiwen%3BLi%2C+Li%3BLin%2C+Simon+M%3BNikolsky%2C+Yuri%3BOberthuer%2C+Andr%C3%A9%3BQing%2C+Tao%3BSu%2C+Zhenqiang%3BVolland%2C+Ruth%3BWang%2C+Charles%3BWang%2C+May+D%3BAi%2C+Junmei%3BAlbanese%2C+Davide%3BAsgharzadeh%2C+Shahab%3BAvigad%2C+Smadar%3BBao%2C+Wenjun%3BBessarabova%2C+Marina%3BBrilliant%2C+Murray+H%3BBrors%2C+Benedikt%3BChierici%2C+Marco%3BChu%2C+Tzu-Ming%3BZhang%2C+Jibin%3BGrundy%2C+Richard+G%3BHe%2C+Min+Max%3BHebbring%2C+Scott%3BKaufman%2C+Howard+L%3BLababidi%2C+Samir%3BLancashire%2C+Lee+J%3BLi%2C+Yan%3BLu%2C+Xin+X%3BLuo%2C+Heng%3BMa%2C+Xiwen%3BNing%2C+Baitang%3BNoguera%2C+Rosa%3BPeifer%2C+Martin%3BPhan%2C+John+H%3BRoels%2C+Frederik%3BRosswog%2C+Carolina%3BShao%2C+Susan%3BShen%2C+Jie%3BTheissen%2C+Jessica%3BTonini%2C+Gian+Paolo%3BVandesompele%2C+Jo%3BWu%2C+Po-Yen%3BXiao%2C+Wenzhong%3BXu%2C+Joshua%3BXu%2C+Weihong%3BXuan%2C+Jiekun%3BYang%2C+Yong%3BYe%2C+Zhan%3BDong%2C+Zirui%3BZhang%2C+Ke+K%3BYin%2C+Ye%3BZhao%2C+Chen%3BZheng%2C+Yuanting%3BWolfinger%2C+Russell+D%3BShi%2C+Tieliu%3BMalkas%2C+Linda+H%3BBerthold%2C+Frank%3BWang%2C+Jun%3BTong%2C+Weida%3BShi%2C+Leming%3BPeng%2C+Zhiyu%3BFischer%2C+Matthias&rft.aulast=Zhang&rft.aufirst=Wenqian&rft.date=2015-06-25&rft.volume=16&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Genome+biology&rft.issn=1474-760X&rft_id=info:doi/10.1186%2Fs13059-015-0694-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-23 N1 - Date created - 2015-07-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Oncol. 2010 Jul 20;28(21):3506-15 [20567016] Nat Biotechnol. 2010 May;28(5):511-5 [20436464] Nat Biotechnol. 2010 Aug;28(8):827-38 [20676074] Nat Rev Genet. 2011 Feb;12(2):87-98 [21191423] Nat Biotechnol. 2011 Aug;29(8):742-9 [21804560] Lancet. 2011 Nov 19;378(9805):1812-23 [22098854] Clin Cancer Res. 2012 Apr 1;18(7):2012-23 [22328561] Cancer Res. 2012 Aug 15;72(16):4074-84 [22700878] Genome Res. 2012 Sep;22(9):1760-74 [22955987] Nature. 2012 Sep 6;489(7414):101-8 [22955620] Bioinformatics. 2013 Jan 15;29(2):273-4 [23172860] Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7413-7 [23589849] Nature. 2013 Jul 4;499(7456):43-9 [23792563] Nucleic Acids Res. 2014 Jan;42(Database issue):D756-63 [24259432] Genome Res. 2014 Feb;24(2):212-26 [24265505] Mol Oncol. 2014 May;8(3):669-78 [24560446] Nat Biotechnol. 2014 Sep;32(9):903-14 [25150838] Nature. 2002 Jan 24;415(6870):436-42 [11807556] Nature. 2002 Jan 31;415(6871):530-6 [11823860] Nat Med. 2002 Aug;8(8):816-24 [12118244] Nat Rev Cancer. 2004 Mar;4(3):177-83 [14993899] J Clin Invest. 2004 Mar;113(6):913-23 [15067324] Oncogene. 1991 Sep;6(9):1555-9 [1923522] J Clin Oncol. 1993 Aug;11(8):1466-77 [8336186] Blood. 2005 Jan 1;105(1):301-7 [15345589] Cancer Cell. 2005 Apr;7(4):337-50 [15837623] J Clin Oncol. 2005 Oct 10;23(29):7332-41 [16145063] Nat Biotechnol. 2006 Sep;24(9):1151-61 [16964229] J Natl Cancer Inst. 2006 Sep 6;98(17):1193-203 [16954472] Genome Biol. 2006;7 Suppl 1:S12.1-14 [16925834] Nat Biotechnol. 2006 Sep;24(9):1162-9 [17061323] J Clin Oncol. 2006 Nov 1;24(31):5070-8 [17075126] Lancet. 2007 Jun 23;369(9579):2106-20 [17586306] Science. 2008 Aug 15;321(5891):956-60 [18599741] Bioinformatics. 2009 May 1;25(9):1105-11 [19289445] Lancet Oncol. 2009 Jul;10(7):663-71 [19515614] Pharmacogenomics J. 2010 Aug;10(4):258-66 [20676065] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s13059-015-0694-1 ER - TY - JOUR T1 - Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. AN - 1691596897; 26010811 AB - Activation of Toll-like receptors has been linked to neuropathic pain and opioid dependence. (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been shown to reverse neuropathic pain in rat studies. We designed and synthesized compounds based on (+)-naltrexone and (+)-noroxymorphone and evaluated their TLR4 antagonist activities by their effects on inhibiting lipopolysaccharide (LPS) induced TLR4 downstream nitric oxide (NO) production in microglia BV-2 cells. Alteration of the N-substituent in (+)-noroxymorphone gave us a potent TLR4 antagonist. The most promising analog, (+)-N-phenethylnoroxymorphone ((4S,4aR,7aS,12bR)-4a,9-dihydroxy-3-phenethyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one, 1j) showed ∼75 times better TLR-4 antagonist activity than (+)-naltrexone, and the ratio of its cell viability IC50, a measure of its toxicity, to TLR-4 antagonist activity (140 μM/1.4 μM) was among the best of the new analogs. This compound (1j) was active in vivo; it significantly increased and prolonged morphine analgesia. JF - Journal of medicinal chemistry AU - Selfridge, Brandon R AU - Wang, Xiaohui AU - Zhang, Yingning AU - Yin, Hang AU - Grace, Peter M AU - Watkins, Linda R AU - Jacobson, Arthur E AU - Rice, Kenner C AD - †Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, Maryland 20892-3373, United States. ; ‡Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, United States. ; §Department of Chemistry and Biochemistry the BioFrontiers Institute, University of Colorado at Boulder, Boulder, Colorado 80309, United States. Y1 - 2015/06/25/ PY - 2015 DA - 2015 Jun 25 SP - 5038 EP - 5052 VL - 58 IS - 12 KW - Analgesics, Opioid KW - 0 KW - Lipopolysaccharides KW - Morphinans KW - Toll-Like Receptor 4 KW - Nitric Oxide KW - 31C4KY9ESH KW - Naltrexone KW - 5S6W795CQM KW - Morphine KW - 76I7G6D29C KW - noroxymorphone KW - 9NZ7111A9O KW - Index Medicus KW - Animals KW - Humans KW - Structure-Activity Relationship KW - Morphine -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Lipopolysaccharides -- immunology KW - Analgesics, Opioid -- pharmacology KW - Microglia -- cytology KW - Microglia -- immunology KW - Nitric Oxide -- immunology KW - Drug Synergism KW - Microglia -- drug effects KW - Cell Line KW - Male KW - Toll-Like Receptor 4 -- immunology KW - Toll-Like Receptor 4 -- antagonists & inhibitors KW - Morphinans -- chemistry KW - Naltrexone -- analogs & derivatives KW - Naltrexone -- pharmacology KW - Morphinans -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691596897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Structure-Activity+Relationships+of+%28%2B%29-Naltrexone-Inspired+Toll-like+Receptor+4+%28TLR4%29+Antagonists.&rft.au=Selfridge%2C+Brandon+R%3BWang%2C+Xiaohui%3BZhang%2C+Yingning%3BYin%2C+Hang%3BGrace%2C+Peter+M%3BWatkins%2C+Linda+R%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Selfridge&rft.aufirst=Brandon&rft.date=2015-06-25&rft.volume=58&rft.issue=12&rft.spage=5038&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Facs.jmedchem.5b00426 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-14 N1 - Date created - 2015-06-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Br J Pharmacol. 2016 Mar;173(5):856-69 [26603732] J Am Chem Soc. 1967 Apr 12;89(8):1942-7 [6040525] Mol Psychiatry. 2015 Dec;20(12):1525-37 [25644383] CNS Neurol Disord Drug Targets. 2015;14(6):692-9 [26022268] Trends Pharmacol Sci. 2014 Sep;35(9):432-3 [25109571] Trends Pharmacol Sci. 2014 Sep;35(9):431-2 [25109569] Nat Rev Drug Discov. 2014 Jul;13(7):533-48 [24948120] J Org Chem. 2014 Jun 6;79(11):5007-18 [24773391] Neuropharmacology. 2014 Jan;76 Pt B:218-27 [23764149] FASEB J. 2013 Jul;27(7):2713-22 [23568774] Chem Soc Rev. 2013 Jun 21;42(12):4859-66 [23503527] Biol Psychiatry. 2013 Apr 15;73(8):729-37 [23384483] Nat Neurosci. 2013 Mar;16(3):253-5 [23434975] J Neurosci. 2012 Aug 15;32(33):11187-200 [22895704] Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6325-30 [22474354] Pharmacol Ther. 2012 May;134(2):219-45 [22316499] Pharmacol Rev. 2011 Sep;63(3):772-810 [21752874] Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11942-7 [20547845] Cell. 2010 Mar 19;140(6):805-20 [20303872] Brain Behav Immun. 2010 Jan;24(1):83-95 [19679181] ALTEX. 2009;26(2):83-94 [19565166] Trends Neurosci. 2009 Jun;32(6):339-46 [19414201] Nature. 2009 Apr 30;458(7242):1191-5 [19252480] Org Lett. 2009 Feb 5;11(3):539-42 [19115979] Anesthesiology. 2009 Jan;110(1):166-81 [19104184] J Org Chem. 2008 Oct 17;73(20):8093-6 [18811203] Eur J Neurosci. 2008 Jul;28(1):20-9 [18662331] Neurosci Biobehav Rev. 2001 Jan;25(1):43-52 [11166077] Nat Rev Immunol. 2014 Apr;14(4):217-31 [24577438] J Med Chem. 1978 Apr;21(4):398-400 [206698] J Med Chem. 1978 Dec;21(12):1320-2 [722742] Pain. 1988 Jan;32(1):77-88 [3340425] J Med Chem. 1992 Jul 24;35(15):2826-35 [1322988] Anal Biochem. 1993 Oct;214(1):11-6 [7504409] J Neurosci Methods. 1999 Aug 1;90(1):81-6 [10517276] J Org Chem. 2005 Mar 4;70(5):1907-10 [15730320] Org Lett. 2005 Jun 23;7(13):2531-4 [15957883] ScientificWorldJournal. 2007;7:98-111 [17982582] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.jmedchem.5b00426 ER - TY - JOUR T1 - Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells. AN - 1680960985; 25882087 AB - The biological consequences of exposure to piperidine nitroxides is a concern, given their widespread use in manufacturing processes and their potential use in clinical applications. Our previous study reported that TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl), a low molecular weight free radical, possesses pro-oxidative activity in L5178Y cells. In this study, we investigated and characterized the role of reactive oxygen species (ROS) in TEMPO-induced toxicity in L5178Y cells. We found that TEMPO induced time- and concentration-dependent intracellular ROS production and glutathione depletion. TEMPO also induced apoptosis as demonstrated by increased caspase-3/7 activity, an increased proportion of annexin V stained cells, and decreased expression of anti-apoptotic proteins including Bcl-2, Bcl-xL and Mcl-1. N-acetylcysteine, a ROS scavenger, attenuated the ROS production and apoptosis induced by TEMPO. Moreover, Western blot analyses revealed that TEMPO activated γ-H2A.X, a hallmark of DNA damage, and c-Jun N-terminal kinases (JNK), a key member in the mitogen-activated protein kinase (MAPK) signaling pathway. Addition of SP600125, a JNK-specific inhibitor, blocked TEMPO-mediated JNK phosphorylation and also attenuated TEMPO-induced apoptosis. These findings indicate that both ROS production and JNK activation are involved in TEMPO-induced apoptosis, and may contribute to the toxicity of TEMPO in L5178Y cells. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Guo, Xiaoqing AU - Chen, Si AU - Zhang, Zhuhong AU - Dobrovolsky, Vasily N AU - Dial, Stacey L AU - Guo, Lei AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States; Tianjin Medical University General Hospital, Tianjin 300052, China. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. Electronic address: nan.mei@fda.hhs.gov. Y1 - 2015/06/25/ PY - 2015 DA - 2015 Jun 25 SP - 27 EP - 36 VL - 235 KW - Bcl2l1 protein, mouse KW - 0 KW - Cyclic N-Oxides KW - Mcl1 protein, mouse KW - Myeloid Cell Leukemia Sequence 1 Protein KW - Proto-Oncogene Proteins c-bcl-2 KW - Reactive Oxygen Species KW - bcl-X Protein KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinases KW - Caspase 3 KW - EC 3.4.22.- KW - Caspase 7 KW - Glutathione KW - GAN16C9B8O KW - TEMPO KW - VQN7359ICQ KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - MAPK pathway KW - Apoptosis KW - Reactive oxygen species KW - Nitroxide KW - Animals KW - Mitogen-Activated Protein Kinases -- metabolism KW - Caspase 7 -- metabolism KW - Glutathione -- metabolism KW - Signal Transduction -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Acetylcysteine -- metabolism KW - Mice KW - Cell Line, Tumor KW - Myeloid Cell Leukemia Sequence 1 Protein -- metabolism KW - bcl-X Protein -- metabolism KW - Phosphorylation -- drug effects KW - Caspase 3 -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Apoptosis -- drug effects KW - Cyclic N-Oxides -- pharmacology KW - JNK Mitogen-Activated Protein Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680960985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Reactive+oxygen+species+and+c-Jun+N-terminal+kinases+contribute+to+TEMPO-induced+apoptosis+in+L5178Y+cells.&rft.au=Guo%2C+Xiaoqing%3BChen%2C+Si%3BZhang%2C+Zhuhong%3BDobrovolsky%2C+Vasily+N%3BDial%2C+Stacey+L%3BGuo%2C+Lei%3BMei%2C+Nan&rft.aulast=Guo&rft.aufirst=Xiaoqing&rft.date=2015-06-25&rft.volume=235&rft.issue=&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2015.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-27 N1 - Date created - 2015-05-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cbi.2015.04.009 ER - TY - JOUR T1 - FDA Approval: Belinostat for the Treatment of Patients with Relapsed or Refractory Peripheral T-cell Lymphoma AN - 1808647305; PQ0003435548 AB - On July 3, 2014, the FDA granted accelerated approval for belinostat (Beleodaq; Spectrum Pharmaceuticals, Inc.), a histone deacetylase inhibitor, for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). A single-arm, open-label, multicenter, international trial in the indicated patient population was submitted in support of the application. Belinostat was administered intravenously at a dose of 1000 mg/m2 over 30 minutes once daily on days 1 to 5 of a 21-day cycle. The primary efficacy endpoint was overall response rate (ORR) based on central radiology readings by an independent review committee. The ORR was 25.8% [95% confidence interval (CI), 18.3-34.6] in 120 patients that had confirmed diagnoses of PTCL by the Central Pathology Review Group. The complete and partial response rates were 10.8% (95% CI, 5.9-17.8) and 15.0% (95% CI, 9.1-22.7), respectively. The median duration of response, the key secondary efficacy endpoint, was 8.4 months (95% CI, 4.5-29.4). The most common adverse reactions (>25%) were nausea, fatigue, pyrexia, anemia, and vomiting. Grade 3/4 toxicities ( greater than or equal to 5.0%) included anemia, thrombocytopenia, dyspnea, neutropenia, fatigue, and pneumonia. Belinostat is the third drug to receive accelerated approval for the treatment of relapsed or refractory PTCL. Clin Cancer Res; 21(12); 2666-70. copyright 2015 AACR. JF - Clinical Cancer Research AU - Lee, Hyon-Zu AU - Kwitkowski, Virginia E AU - Del Valle, Pedro L AU - Ricci, MStacey AU - Saber, Haleh AU - Habtemariam, Bahru A AU - Bullock, Julie AU - Bloomquist, Erik AU - Li Shen, Yuan AU - Chen, Xiao-Hong AU - Brown, Janice AU - Mehrotra, Nitin AU - Dorff, Sarah AU - Charlab, Rosane AU - Kane, Robert C AU - Kaminskas, Edvardas AU - Justice, Robert AU - Farrell, Ann T AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, Hyon.Lee@fda.hhs.gov Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 2666 EP - 2670 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 21 IS - 12 SN - 1078-0432, 1078-0432 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Histone deacetylase KW - Vomiting KW - Fatigue KW - Respiration KW - Anemia KW - Toxicity KW - Radiology KW - Clinical trials KW - Cancer KW - Fever KW - Neutropenia KW - Thrombocytopenia KW - Pharmaceuticals KW - Nausea KW - Language KW - T-cell lymphoma KW - Dyspnea KW - Pneumonia KW - Side effects KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808647305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=FDA+Approval%3A+Belinostat+for+the+Treatment+of+Patients+with+Relapsed+or+Refractory+Peripheral+T-cell+Lymphoma&rft.au=Lee%2C+Hyon-Zu%3BKwitkowski%2C+Virginia+E%3BDel+Valle%2C+Pedro+L%3BRicci%2C+MStacey%3BSaber%2C+Haleh%3BHabtemariam%2C+Bahru+A%3BBullock%2C+Julie%3BBloomquist%2C+Erik%3BLi+Shen%2C+Yuan%3BChen%2C+Xiao-Hong%3BBrown%2C+Janice%3BMehrotra%2C+Nitin%3BDorff%2C+Sarah%3BCharlab%2C+Rosane%3BKane%2C+Robert+C%3BKaminskas%2C+Edvardas%3BJustice%2C+Robert%3BFarrell%2C+Ann+T%3BPazdur%2C+Richard&rft.aulast=Lee&rft.aufirst=Hyon-Zu&rft.date=2015-06-15&rft.volume=21&rft.issue=12&rft.spage=2666&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-3119 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Fatigue; Vomiting; Respiration; Anemia; Toxicity; Radiology; Clinical trials; Cancer; Fever; Neutropenia; Thrombocytopenia; Pharmaceuticals; Language; Nausea; T-cell lymphoma; Dyspnea; Side effects; Pneumonia DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-3119 ER - TY - JOUR T1 - Mechanisms of tolvaptan-induced toxicity in HepG2 cells. AN - 1684431233; 25858412 AB - Tolvaptan, a vasopressin receptor 2 antagonist used to treat hyponatremia, has recently been reported to be associated with an increased risk of liver injury. In this study, we explored the underlying mechanisms of hepatotoxicity of tolvaptan using human HepG2 cells. Tolvaptan inhibited cell growth and caused cell death in a concentration- and time-dependent manner. Tolvaptan treatment led to delayed cell cycle progression, accompanied by decreased levels of several cyclins and cyclin-dependent kinases. Tolvaptan was found to cause DNA damage, as assessed by alkaline comet assays; this was confirmed by increased levels of 8-oxoguanine and phosphorylation of histone H2AX. Exposure of HepG2 cells to tolvaptan enhanced cytochrome C release and triggered apoptosis by modulating Bcl-2 family members. The activation of p38 contributed to tolvaptan-mediated apoptosis via down-regulation of Bcl-2. Proteasome inhibition altered tolvaptan-induced cell cycle deregulation and enhanced tolvaptan-induced apoptosis and cytotoxicity. Moreover, tolvaptan treatment induced autophagy. Inhibition of autophagy by knocking-down an autophagy-related gene increased tolvaptan-induced apoptosis and cytotoxicity. Taken together, our findings suggest that the cytotoxicity of tolvaptan results from delayed cell cycle progression, the induction of DNA damage, and the execution of apoptosis. In addition, a number of signaling pathways were perturbed by tolvaptan and played an important role in its cytotoxicity. Published by Elsevier Inc. JF - Biochemical pharmacology AU - Wu, Yuanfeng AU - Beland, Frederick A AU - Chen, Si AU - Liu, Fang AU - Guo, Lei AU - Fang, Jia-Long AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: jia-long.fang@fda.hhs.gov. Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 324 EP - 336 VL - 95 IS - 4 KW - Antidiuretic Hormone Receptor Antagonists KW - 0 KW - Benzazepines KW - Cyclin D3 KW - Proteasome Inhibitors KW - tolvaptan KW - 21G72T1950 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Cyclin-Dependent Kinase 4 KW - EC 2.7.11.22 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Liver injury KW - DNA damage KW - Apoptosis KW - Autophagy KW - Tolvaptan KW - Proteasome KW - Autophagy -- drug effects KW - Proteasome Inhibitors -- pharmacology KW - Mitogen-Activated Protein Kinases -- metabolism KW - Cyclin D3 -- metabolism KW - Enzyme Activation KW - Humans KW - Proteasome Endopeptidase Complex -- drug effects KW - Cytochrome P-450 CYP3A -- genetics KW - Cell Death -- drug effects KW - Cell Proliferation KW - DNA Damage -- drug effects KW - Cyclin-Dependent Kinase 4 -- metabolism KW - Proteasome Endopeptidase Complex -- metabolism KW - Hep G2 Cells KW - Cytochrome P-450 CYP3A -- metabolism KW - Apoptosis -- drug effects KW - Cell Cycle -- drug effects KW - Benzazepines -- toxicity KW - Antidiuretic Hormone Receptor Antagonists -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684431233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Mechanisms+of+tolvaptan-induced+toxicity+in+HepG2+cells.&rft.au=Wu%2C+Yuanfeng%3BBeland%2C+Frederick+A%3BChen%2C+Si%3BLiu%2C+Fang%3BGuo%2C+Lei%3BFang%2C+Jia-Long&rft.aulast=Wu&rft.aufirst=Yuanfeng&rft.date=2015-06-15&rft.volume=95&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2015.03.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-12 N1 - Date created - 2015-05-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcp.2015.03.015 ER - TY - JOUR T1 - Metal contamination of home garden soils and cultivated vegetables in the province of Brescia, Italy: implications for human exposure. AN - 1671213137; 25777956 AB - For the past century, ferroalloy industries in Brescia province, Italy produced particulate emissions enriched in manganese (Mn), lead (Pb), zinc (Zn), copper (Cu), cadmium (Cd), chromium (Cr), iron (Fe), and aluminum (Al). This study assessed metal concentrations in soil and vegetables of regions with varying ferroalloy industrial activity levels. Home gardens (n=63) were selected in three regions of varying ferroalloy plant activity durations in Brescia province. Total soil metal concentration and extractability were measured by X-Ray Fluorescence (XRF), aqua regia extraction, and modified Community Bureau of Reference (BCR) sequential extraction. Unwashed and washed spinach and turnips cultivated in the same gardens were analyzed for metal concentrations by flame atomic absorption spectrometry. Median soil Al, Cd, Fe, Mn, Pb, and Zn concentrations were significantly higher in home gardens near ferroalloy plants compared to reference home gardens. The BCR method yielded the most mobile soil fraction (the sum of extractable metals in Fractions 1 and 2) and all metal concentrations were higher in ferroalloy plant areas. Unwashed spinach showed higher metal concentrations compared to washed spinach. However, some metals in washed spinach were higher in the reference area likely due to history of agricultural product use. Over 60% of spinach samples exceeded the 2- to 4-fold Commission of European Communities and Codex Alimentarius Commission maximum Pb concentrations, and 10% of the same spinach samples exceeded 2- to 3-fold maximum Cd concentrations set by both organizations. Turnip metal concentrations were below maximum standard reference values. Prolonged industrial emissions increase median metal concentrations and most soluble fractions (BCR F1+F2) in home garden soils near ferroalloy plants. Areas near ferroalloy plant sites had spinach Cd and Pb metal concentrations several-fold above maximum standard references. We recommend thorough washing of vegetables to minimize metal exposure. Copyright © 2015 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Ferri, Roberta AU - Hashim, Dana AU - Smith, Donald R AU - Guazzetti, Stefano AU - Donna, Filippo AU - Ferretti, Enrica AU - Curatolo, Michele AU - Moneta, Caterina AU - Beone, Gian Maria AU - Lucchini, Roberto G AD - Occupational Health, University of Brescia, Italy. ; Occupational and Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, USA. ; Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA. ; Public Health Service, Reggio Emilia, Italy. ; Department of Food Chemistry, Metal Laboratory, IZSLER, Brescia, Italy. ; Institute of Agricultural and Environmental Chemistry, Università Cattolica, Piacenza, Italy. ; Occupational Health, University of Brescia, Italy; Occupational and Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, USA; Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA. Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 507 EP - 517 VL - 518-519 KW - Metals KW - 0 KW - Soil KW - Soil Pollutants KW - Index Medicus KW - Phytoavailability KW - Vegetables KW - Ferroalloy industry emissions KW - Metal KW - Modified BCR sequential extraction procedure KW - Brescia KW - Plant uptake KW - Italy KW - Environmental Monitoring KW - Humans KW - Gardening KW - Vegetables -- chemistry KW - Environmental Exposure -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Soil -- chemistry KW - Metals -- analysis KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671213137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Metal+contamination+of+home+garden+soils+and+cultivated+vegetables+in+the+province+of+Brescia%2C+Italy%3A+implications+for+human+exposure.&rft.au=Ferri%2C+Roberta%3BHashim%2C+Dana%3BSmith%2C+Donald+R%3BGuazzetti%2C+Stefano%3BDonna%2C+Filippo%3BFerretti%2C+Enrica%3BCuratolo%2C+Michele%3BMoneta%2C+Caterina%3BBeone%2C+Gian+Maria%3BLucchini%2C+Roberto+G&rft.aulast=Ferri&rft.aufirst=Roberta&rft.date=2015-06-15&rft.volume=518-519&rft.issue=&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.02.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-11 N1 - Date created - 2015-04-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2004 Feb;112(2):215-21 [14754576] Environ Int. 2004 Jun;30(4):467-70 [15031005] Environ Geochem Health. 2004 Mar;26(1):27-36 [15214611] Ecotoxicol Environ Saf. 1997 Apr;36(3):258-68 [9143454] Anal Bioanal Chem. 2004 Nov;380(5-6):813-7 [15517201] Environ Int. 2005 Aug;31(6):784-90 [15979144] Environ Sci Technol. 2005 Oct 1;39(19):7410-5 [16245809] Bull Environ Contam Toxicol. 2006 Feb;76(2):311-9 [16468012] Environ Res. 2006 May;101(1):1-10 [16171795] Chemosphere. 2006 Jun;64(1):161-73 [16330080] Environ Pollut. 2007 Jan;145(1):121-30 [16777287] Sci Total Environ. 2007 Sep 20;383(1-3):81-9 [17573096] J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007 Jul 15;42(9):1241-50 [17654144] Am J Ind Med. 2007 Nov;50(11):788-800 [17918215] Chemosphere. 2008 Feb;70(8):1459-67 [17936872] Environ Pollut. 2008 Mar;152(2):330-41 [17655986] Public Health Nutr. 2009 Dec;12(12):2504-32 [19278564] J Environ Qual. 2010 Sep-Oct;39(5):1616-23 [21043267] Environ Monit Assess. 2011 Jan;172(1-4):319-27 [20165975] Environ Monit Assess. 2011 Apr;175(1-4):303-14 [20499161] J Hazard Mater. 2011 Jun 15;190(1-3):177-87 [21470776] Int J Environ Res Public Health. 2011 Jun;8(6):1805-16 [21776203] J Food Sci. 2011 Oct;76(8):T181-8 [21913923] Environ Pollut. 2012 Jun;165:124-32 [22445920] J Trace Elem Med Biol. 2012 Jun;26(2-3):179-82 [22664337] Neurotoxicology. 2012 Aug;33(4):687-96 [22322213] Environ Sci Pollut Res Int. 2013 Jul;20(7):5067-75 [23338992] Neurotoxicology. 2014 Dec;45:309-17 [24881811] J Environ Monit. 2000 Jun;2(3):228-33 [11256704] J Environ Monit. 1999 Feb;1(1):57-61 [11529080] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.02.072 ER - TY - JOUR T1 - Sensitive detection of active Shiga toxin using low cost CCD based optical detector. AN - 1660413065; 25677808 AB - To reduce the sources and incidence of food-borne illness there is a need to develop affordable, sensitive devices for detection of active toxins, such as Shiga toxin type 2 (Stx2). Currently the widely used methods for measuring Shiga toxin are immunoassay that cannot distinguish between the active form of the toxin, which poses a threat to life, to the inactive form which can bind to antibodies but show no toxicity. In this work, we determine toxin activity based on Shiga toxin inhibition of green fluorescent protein (GFP) combined with low cost charge-coupled device (CCD) fluorescence detection, which is more clinically relevant than immunoassay. For assay detection, a simple low cost fluorescence detection system was constructed using a CCD camera and light emitting diode (LED) excitation source, to measure GFP expression. The system was evaluated and compared to a commercial fluorometer using photomultiplier detection for detecting active Stx2 in the range 100 ng/mL-0.01 pg/mL. The result shows that there is a negative linear relationship between Stx2 concentrations and luminous intensity of GFP, imaged by the CCD camera (R(2)=0.85) or fluorometer (R(2)=0.86). The low cost (∼$300) CCD camera is capable of detecting Shiga toxin activity at comparable levels as a more expensive (∼$30,000) fluorometer. These results demonstrate the utility and the potential of low cost detectors for toxin activity; this approach may increase the availability of foodborne bacterial toxin diagnostics in regions where there are limited resources and could be readily adapted to the detection of other food-borne toxins. Published by Elsevier B.V. JF - Biosensors & bioelectronics AU - Rasooly, Reuven AU - Balsam, Josh AU - Hernlem, Bradley J AU - Rasooly, Avraham AD - Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, United States. Electronic address: reuven.rasooly@ars.usda.gov. ; Division of Biology, Office of Science and Engineering, FDA, Silver Spring, MD 20993, United States; University of Maryland, College Park, MD 20742, United States. ; Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, United States. ; Division of Biology, Office of Science and Engineering, FDA, Silver Spring, MD 20993, United States; Office of Cancer Complementary and Alternative Medicine, National Cancer Institute, Rockville, MD 20850, United States. Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 705 EP - 711 VL - 68 KW - Shiga Toxin 2 KW - 0 KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Food KW - Adenovirus KW - CCD camera KW - Shiga toxin KW - Humans KW - Food Analysis KW - Shiga Toxin 2 -- isolation & purification KW - Biosensing Techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660413065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+%26+bioelectronics&rft.atitle=Sensitive+detection+of+active+Shiga+toxin+using+low+cost+CCD+based+optical+detector.&rft.au=Rasooly%2C+Reuven%3BBalsam%2C+Josh%3BHernlem%2C+Bradley+J%3BRasooly%2C+Avraham&rft.aulast=Rasooly&rft.aufirst=Reuven&rft.date=2015-06-15&rft.volume=68&rft.issue=&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Biosensors+%26+bioelectronics&rft.issn=1873-4235&rft_id=info:doi/10.1016%2Fj.bios.2015.01.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-25 N1 - Date created - 2015-03-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bios.2015.01.065 ER - TY - JOUR T1 - Surveillance of antibiotic resistance AN - 1808698139; PQ0003431084 AB - Surveillance involves the collection and analysis of data for the detection and monitoring of threats to public health. Surveillance should also inform as to the epidemiology of the threat and its burden in the population. A further key component of surveillance is the timely feedback of data to stakeholders with a view to generating action aimed at reducing or preventing the public health threat being monitored. Surveillance of antibiotic resistance involves the collection of antibiotic susceptibility test results undertaken by microbiology laboratories on bacteria isolated from clinical samples sent for investigation. Correlation of these data with demographic and clinical data for the patient populations from whom the pathogens were isolated gives insight into the underlying epidemiology and facilitates the formulation of rational interventions aimed at reducing the burden of resistance. This article describes a range of surveillance activities that have been undertaken in the UK over a number of years, together with current interventions being implemented. These activities are not only of national importance but form part of the international response to the global threat posed by antibiotic resistance. JF - Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences AU - Johnson, Alan P AD - Department of Healthcare-Associated Infection and Antimicrobial Resistance, Centre for Infectious Disease Surveillance and Control, , Public Health England, London NW9 5EQ, UK, alan.johnson@phe.gov.uk Y1 - 2015/06/05/ PY - 2015 DA - 2015 Jun 05 SP - 20140080 PB - Royal Society of London, 6 Carlton House Terrace London SW1Y 5AG United Kingdom VL - 370 IS - 1670 SN - 0962-8436, 0962-8436 KW - Ecology Abstracts KW - antibiotic susceptibility testing KW - public health threat KW - interventions KW - Demography KW - Data processing KW - Epidemiology KW - Antibiotics KW - Feedback KW - Pathogens KW - Antibiotic resistance KW - Public health KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808698139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Philosophical+Transactions+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.atitle=Surveillance+of+antibiotic+resistance&rft.au=Johnson%2C+Alan+P&rft.aulast=Johnson&rft.aufirst=Alan&rft.date=2015-06-05&rft.volume=370&rft.issue=1670&rft.spage=20140080&rft.isbn=&rft.btitle=&rft.title=Philosophical+Transactions+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.issn=09628436&rft_id=info:doi/10.1098%2Frstb.2014.0080 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Demography; Data processing; Epidemiology; Feedback; Antibiotics; Pathogens; Antibiotic resistance; Public health DO - http://dx.doi.org/10.1098/rstb.2014.0080 ER - TY - JOUR T1 - Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study. AN - 1686415287; 24863738 AB - In vitro-derived information has been increasingly used to support and improve human health risk assessment for exposure to chemicals. Physiologically based pharmacokinetic (PBPK) modeling is a key component in the movement toward in vitro-based risk assessment, providing a tool to integrate diverse experimental data and mechanistic information to relate in vitro effective concentrations to equivalent human exposures. One of the challenges, however, in the use of PBPK models for this purpose has been the need for extensive chemical-specific parameters. With the remarkable advances in in vitro methodologies in recent years, in vitro-derived parameters can now be easily incorporated into PBPK models. In this study we demonstrate an in vitro data based parameterization approach to develop a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model, using carbaryl as a case study. In vitro experiments were performed to provide the chemical-specific pharmacokinetic (PK) and pharmacodynamic (PD) parameters for carbaryl in the PBPK model for this compound. Metabolic clearance and cholinesterase (ChE) interaction parameters for carbaryl were measured in rat and human tissues. These in vitro PK and PD data were extrapolated to parameters in the whole body PBPK model using biologically appropriate scaling. The PBPK model was then used to predict the kinetics and ChE inhibition dynamics of carbaryl in vivo. This case study with carbaryl provides a reasonably successful example of utilizing the in vitro to in vivo extrapolation (IVIVE) approach for PBPK model development. This approach can be applied to other carbamates with an anticholinesterase mode of action as well as to environmental chemicals in general with further refinement of the current shortcomings in the approach. It will contribute to minimizing the need for in vivo human data for PBPK model parameterization and evaluation in human risk assessments. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology AU - Yoon, Miyoung AU - Kedderis, Gregory L AU - Yan, Grace Zhixia AU - Clewell, Harvey J AD - Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address: myoon@thehamner.org. ; Independent Consultant, Chapel Hill, NC, USA. Electronic address: gkedderis@msn.com. ; Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address: Zhixia.Yan@fda.hhs.gov. ; Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address: hclewell@thehamner.org. Y1 - 2015/06/05/ PY - 2015 DA - 2015 Jun 05 SP - 52 EP - 66 VL - 332 KW - Cholinesterase Inhibitors KW - 0 KW - Cholinesterases KW - EC 3.1.1.8 KW - Carbaryl KW - R890C8J3N1 KW - Index Medicus KW - In vitro to in vivo extrapolation KW - Cholinesterase inhibition KW - Hepatocytes KW - PBPK model KW - Metabolism KW - Young Adult KW - Animal Testing Alternatives KW - Animals KW - Erythrocytes -- drug effects KW - Hepatocytes -- drug effects KW - Computer Simulation KW - Humans KW - Brain -- drug effects KW - Linear Models KW - Metabolic Clearance Rate KW - Hepatocytes -- enzymology KW - Risk Assessment KW - Brain -- enzymology KW - Rats, Sprague-Dawley KW - Erythrocytes -- enzymology KW - Biotransformation KW - Cells, Cultured KW - Risk Factors KW - Adult KW - Middle Aged KW - Species Specificity KW - Male KW - Female KW - Cholinesterases -- metabolism KW - Cholinesterase Inhibitors -- toxicity KW - Toxicity Tests -- methods KW - Cholinesterase Inhibitors -- pharmacokinetics KW - Cholinesterase Inhibitors -- blood KW - Carbaryl -- toxicity KW - Carbaryl -- pharmacokinetics KW - Carbaryl -- blood KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686415287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Use+of+in+vitro+data+in+developing+a+physiologically+based+pharmacokinetic+model%3A+Carbaryl+as+a+case+study.&rft.au=Yoon%2C+Miyoung%3BKedderis%2C+Gregory+L%3BYan%2C+Grace+Zhixia%3BClewell%2C+Harvey+J&rft.aulast=Yoon&rft.aufirst=Miyoung&rft.date=2015-06-05&rft.volume=332&rft.issue=&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2014.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-13 N1 - Date created - 2015-06-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2014.05.006 ER - TY - JOUR T1 - Characterisation and potential migration of silver nanoparticles from commercially available polymeric food contact materials AN - 1694983241; PQ0001611034 AB - The potential for consumer exposure to nano-components in food contact materials (FCMs) is dependent on the migration of nanomaterials into food. Therefore, characterising the physico-chemical properties and potential for migration of constituents is an important step in assessing the safety of FCMs. A number of commercially available food storage products, purchased domestically within the United States and internationally, that claim to contain nanosilver were evaluated. The products were made of polyethylene, polypropylene and polyphenylene ether sulfone and all contained silver (0.001-36 mg kg super(-1) of polymer). Silver migration was measured under various conditions, including using 3% acetic acid and water as food simulants. Low concentrations (sub-ppb levels) of silver were detected in the migration studies generally following a trend characterised by a surface desorption phenomenon, where the majority of the silver migration occurred in the first of three consecutive exposures. Silver nanoparticles were not detected in food simulants, suggesting that the silver migration may be due solely to ionic silver released into solution from oxidation of the silver nanoparticle surface. The absence of detectable silver nanoparticles was consistent with expectations from a physico-chemical view point. For the products tested, current USFDA guidance for evaluating migration from FCMs was applicable. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Addo Ntim, Susana AU - Thomas, Treye A AU - Begley, Timothy H AU - Noonan, Gregory O AD - US Food and Drug Administration (USFDA), Center for Food Safety and Applied Nutrition, College Park, MD, USA Y1 - 2015/06/03/ PY - 2015 DA - 2015 Jun 03 SP - 1003 EP - 1011 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 6 SN - 1944-0049, 1944-0049 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Risk assessment KW - Desorption KW - Physicochemical properties KW - Safety KW - Migration KW - Nanotechnology KW - USA KW - Food additives KW - Oxidation KW - Food storage KW - Ethers KW - Polymers KW - Silver KW - H 9000:Consumer and Recreation Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694983241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Characterisation+and+potential+migration+of+silver+nanoparticles+from+commercially+available+polymeric+food+contact+materials&rft.au=Addo+Ntim%2C+Susana%3BThomas%2C+Treye+A%3BBegley%2C+Timothy+H%3BNoonan%2C+Gregory+O&rft.aulast=Addo+Ntim&rft.aufirst=Susana&rft.date=2015-06-03&rft.volume=32&rft.issue=6&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1029994 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Desorption; Oxidation; Safety; Physicochemical properties; Food storage; Ethers; Polymers; Migration; Silver; Nanotechnology; USA DO - http://dx.doi.org/10.1080/19440049.2015.1029994 ER - TY - JOUR T1 - Development and utility of the FDA 'GutProbe' DNA microarray for identification, genotyping and metagenomic analysis of commercially available probiotics AN - 1787984438; PQ0002928257 AB - Aim Lactic acid bacteria are beneficial microbes added to many food products and dietary supplements for their purported health benefits. Proper identification of bacteria is important to assess safety as well as proper product labelling. A custom microarray (FDA GutProbe) was developed to verify accurate labelling in commercial dietary supplements. Methods and Results Strain-specific attribution was achieved with GutProbe array which contains genes from the most commonly found species in probiotic supplements and food ingredients. Applied utility of the array was assessed with direct from product DNA hybridization to determine (i) if identification of multiple strains in one sample can be conducted and (ii) if any lot-to-lot variations exist with eight probiotics found on the US market. Conclusions GutProbe is a useful tool in identifying a mixture of microbials in probiotics and did reveal some product variations. In addition, the array is able to identify lot-to-lot differences in these products. These strain level attribution may be useful for routine monitoring of batch variation as part of a 'Good Manufacturing Practices' process. Significance and Impact of the Study The FDA GutProbe is an efficient and reliable platform to identify the presence of microbial ingredients and determining microbe differences in dietary supplements. The GutProbe is a fast, rapid method for direct community profiling or food matrix sampling. JF - Journal of Applied Microbiology AU - Patro, J N AU - Ramachandran, P AU - Lewis, J L AU - Mammel, M K AU - Barnaba, T AU - Pfeiler, E A AU - Elkins, CA AD - Division of Molecular Biology, Center for Food Safety & Applied Nutrition, U.S. Food and Drug Administration, Muirkirk Rd Laurel, MD, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1478 EP - 1488 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 118 IS - 6 SN - 1364-5072, 1364-5072 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Dietary supplements KW - Food KW - Genotyping KW - Safety KW - FDA KW - DNA KW - probiotics KW - Sampling KW - Lactic acid bacteria KW - DNA microarrays KW - J 02310:Genetics & Taxonomy KW - W 30910:Imaging KW - A 01330:Food Microbiology KW - ENA 21:Wildlife KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787984438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Development+and+utility+of+the+FDA+%27GutProbe%27+DNA+microarray+for+identification%2C+genotyping+and+metagenomic+analysis+of+commercially+available+probiotics&rft.au=Patro%2C+J+N%3BRamachandran%2C+P%3BLewis%2C+J+L%3BMammel%2C+M+K%3BBarnaba%2C+T%3BPfeiler%2C+E+A%3BElkins%2C+CA&rft.aulast=Patro&rft.aufirst=J&rft.date=2015-06-01&rft.volume=118&rft.issue=6&rft.spage=1478&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.12795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Genotyping; Food; Dietary supplements; probiotics; Lactic acid bacteria; Sampling; DNA microarrays; Safety; DNA; FDA DO - http://dx.doi.org/10.1111/jam.12795 ER - TY - JOUR T1 - Comment on "Concerns with amplitude variation in calibrated audiometer systems in clinical simulations" AN - 1787974031; PQ0002994323 JF - Noise and Health AU - Byrne, David C AU - Themann, Christa L AU - Stephenson, Mark R AD - Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 172 PB - University College London, 330 Gray's Inn Road London WC1X 8EE United Kingdom VL - 17 IS - 76 SN - 1463-1741, 1463-1741 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787974031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+and+Health&rft.atitle=Comment+on+%22Concerns+with+amplitude+variation+in+calibrated+audiometer+systems+in+clinical+simulations%22&rft.au=Byrne%2C+David+C%3BThemann%2C+Christa+L%3BStephenson%2C+Mark+R&rft.aulast=Byrne&rft.aufirst=David&rft.date=2015-06-01&rft.volume=17&rft.issue=76&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Noise+and+Health&rft.issn=14631741&rft_id=info:doi/10.4103%2F1463-1741.155851 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-05-11 DO - http://dx.doi.org/10.4103/1463-1741.155851 ER - TY - JOUR T1 - Long-Term Care Financing: Lessons From France AN - 1748859441; 2011-871667 AB - Context An aging population leads to a growing demand for long-term services and supports (LTSS). In 2002, France introduced universal, income-adjusted, public long-term care coverage for adults 60 and older, whereas the United States funds means-tested benefits only. Both countries have private long-term care insurance (LTCI) markets: American policies create alternatives to out-of-pocket spending and protect purchasers from relying on Medicaid. Sales, however, have stagnated, and the market's viability is uncertain. In France, private LTCI supplements public coverage, and sales are growing, although its potential to alleviate the long-term care financing problem is unclear. We explore whether France's very different approach to structuring public and private financing for long-term care could inform the United States' long-term care financing reform efforts. Methods We consulted insurance experts and conducted a detailed review of public reports, academic studies, and other documents to understand the public and private LTCI systems in France, their advantages and disadvantages, and the factors affecting their development. Findings France provides universal public coverage for paid assistance with functional dependency for people 60 and older. Benefits are steeply income adjusted and amounts are low. Nevertheless, expenditures have exceeded projections, burdening local governments. Private supplemental insurance covers 11% of French, mostly middle-income adults (versus 3% of Americans 18 and older). Whether policyholders will maintain employer-sponsored coverage after retirement is not known. The government's interest in pursuing an explicit public/private partnership has waned under President Francois Hollande, a centrist socialist, in contrast to the previous center-right leader, President Nicolas Sarkozy, thereby reducing the prospects of a coordinated public/private strategy. Conclusions American private insurers are showing increasing interest in long-term care financing approaches that combine public and private elements. The French example shows how a simple, cheap, cash-based product can gain traction among middle-income individuals when offered by employers and combined with a steeply income-adjusted universal public program. The adequacy of such coverage, however, is a concern. Adapted from the source document. JF - The Milbank Quarterly AU - Doty, Pamela AU - NADASH, PAMELA AU - RACCO, NATHALIE AD - US Department of Health and Human Services. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 359 EP - 391 PB - Blackwell Publishers, Malden MA VL - 93 IS - 2 SN - 0887-378X, 0887-378X KW - United States KW - Partnership KW - Sales KW - Presidents KW - Medicaid program KW - Appropriations and expenditures KW - Local government KW - Adults KW - Insurance KW - Retirement KW - Income KW - France KW - Sarkozy, Nicolas KW - Population aging KW - Markets KW - Benefits KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1748859441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Milbank+Quarterly&rft.atitle=Long-Term+Care+Financing%3A+Lessons+From+France&rft.au=Doty%2C+Pamela%3BNADASH%2C+PAMELA%3BRACCO%2C+NATHALIE&rft.aulast=Doty&rft.aufirst=Pamela&rft.date=2015-06-01&rft.volume=93&rft.issue=2&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=The+Milbank+Quarterly&rft.issn=0887378X&rft_id=info:doi/10.1111%2F1468-0009.12125 LA - English DB - PAIS Index N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-09-28 N1 - CODEN - MIQUES N1 - SubjectsTermNotLitGenreText - France; Insurance; Presidents; Population aging; United States; Benefits; Adults; Sales; Sarkozy, Nicolas; Local government; Medicaid program; Markets; Partnership; Appropriations and expenditures; Retirement; Income DO - http://dx.doi.org/10.1111/1468-0009.12125 ER - TY - JOUR T1 - Developing osteoblasts as an endpoint for the mouse embryonic stem cell test AN - 1735915928; PQ0002267949 AB - The mouse Embryonic Stem cell Test (EST) using cardiomyocyte differentiation is a promising in vitro assay for detecting potential embryotoxicity; however, the addition of another differentiation endpoint, such as osteoblasts, may improve the predictive value of the test. A number of variables such as culture conditions and starting cell number were investigated. A 14 day direct plating method of D3 mouse embryonic stem cells (mESCs) was used to test the predictivity of osteoblast differentiation as an endpoint in the EST. Twelve compounds were tested using the prediction model developed in the ECVAM validation study. Eight of the compounds selected from the EST validation study served as model compounds; four additional compounds known to produce skeletal defects were also tested. Our results indicate comparable chemical classification between the validated cardiomyocyte endpoint and the osteoblast endpoint. These results suggest that differentiation to osteoblasts may provide confirmatory information in predicting embryotoxicity. JF - Reproductive Toxicology AU - Chen, Xinrong AU - Hansen, Deborah K AU - Merry, Gwenn AU - DeJarnette, Christian AU - Nolen, Greg AU - Sloper, Daniel AU - Fisher, JEdward AU - Harrouk, Wafa AU - Tassinari, Melissa S AU - Inselman, Amy L AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 131 EP - 140 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 53 SN - 0890-6238, 0890-6238 KW - Genetics Abstracts; Calcium & Calcified Tissue Abstracts; Toxicology Abstracts KW - Osteoblast KW - Cardiomyocyte KW - Embryonic stem cell test KW - Embryotoxicity KW - Alternative model KW - In vitro KW - EST Embryonic Stem cell Test KW - mESCs mouse embryonic stem cells KW - ESCs embryonic stem cells KW - EB embryoid body KW - ECVAM European Centre for the Validation of Alternative Methods KW - PMEF primary mouse embryonic fibroblasts KW - FBS fetal bovine serum KW - DMEM Dulbecco's Modified Eagle medium KW - DMSO dimethyl sulfoxide KW - 5FU 5-fluorouracil KW - HU hydroxyurea KW - DPH diphenhydramine hydrochloride KW - MTX methotrexate hydrate KW - LC lithium chloride KW - AC acrylamide KW - VPA valproic acid KW - PG penicillin G KW - ACE acetazolamide KW - CS cadmium sulfate KW - 6MP 6-mercaptopurine monohydrate KW - TH thalidomide KW - ALR alizarin red S KW - Bglap bone gamma carboxyglutamate protein KW - Oct-4 octamer-binding transcription factor 4 KW - Runx2 runt related transcription factor 2 KW - IC503T3 50% viability of 3T3 cells KW - IC50D3 50% viability of D3 cells KW - ID50Ob or CM 50% inhibition of differentiation of osteoblasts or cardiomyocytes KW - Osteoblastogenesis KW - Osteoblasts KW - Stem cells KW - Embryo cells KW - Cell number KW - Cell culture KW - cardiomyocytes KW - expressed sequence tags KW - G 07730:Development & Cell Cycle KW - T 2025:Bone and Bone Diseases KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735915928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Developing+osteoblasts+as+an+endpoint+for+the+mouse+embryonic+stem+cell+test&rft.au=Chen%2C+Xinrong%3BHansen%2C+Deborah+K%3BMerry%2C+Gwenn%3BDeJarnette%2C+Christian%3BNolen%2C+Greg%3BSloper%2C+Daniel%3BFisher%2C+JEdward%3BHarrouk%2C+Wafa%3BTassinari%2C+Melissa+S%3BInselman%2C+Amy+L&rft.aulast=Chen&rft.aufirst=Xinrong&rft.date=2015-06-01&rft.volume=53&rft.issue=&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2015.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Osteoblasts; Osteoblastogenesis; Stem cells; Cell number; Embryo cells; Cell culture; cardiomyocytes; expressed sequence tags DO - http://dx.doi.org/10.1016/j.reprotox.2015.04.008 ER - TY - JOUR T1 - Foreword: The Global Pandemic of Falsified Medicines: Laboratory and Field Innovations and Policy Implications AN - 1727682298; PQ0002197807 AB - It is a privilege to introduce this collection of articles in the American Journal of Tropical Medicine and Hygiene on the global threat of falsified medicines. Substandard and falsified medical products pose significant risks to global health with potentially devastating and far-reaching consequences. The articles contained in this issue address this threat by exploring new technology for identifying falsified medicines, field innovations for defining their prevalence, and the broader policy implications that demand our attention. It is my hope that this collection contributes to the goal of addressing falsified medicines by identifying not only the nature and scope of a pressing global health problem but also ways to solve it. JF - American Journal of Tropical Medicine and Hygiene AU - Hamburg, Margaret AD - U.S. Food and Drug Administration, Silver Spring, Maryland, commissioner@fda.hhs.gov Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - pandemics KW - Policies KW - Medical equipment KW - Medicine KW - Hygiene KW - Q1 08121:Law, policy, economics and social sciences KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03420:Plant Diseases KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727682298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Foreword%3A+The+Global+Pandemic+of+Falsified+Medicines%3A+Laboratory+and+Field+Innovations+and+Policy+Implications&rft.au=Hamburg%2C+Margaret&rft.aulast=Hamburg&rft.aufirst=Margaret&rft.date=2015-06-01&rft.volume=92&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Policies; Medicine; Hygiene; pandemics; Medical equipment DO - http://dx.doi.org/10.4269/ajtmh.15-0046 ER - TY - JOUR T1 - Biotransformation of Steroids and Flavonoids by Cultures of Aspergillus niger AN - 1709180755; PQ0001900374 AB - Steroids are derivatives of the triterpenoid squalene, containing three fused cyclohexane rings and a cyclopentane ring, and flavonoids are derivatives of L-phenylalanine, containing two aromatic rings joined by a three-carbon bridge that may form part of a heterocyclic ring. A great variety of steroids and flavonoids are produced by plants, and many additional steroids are produced by animals or fungi. Because these compounds have many nutritional and pharmaceutical values, and many of them cannot be produced by chemical synthesis, biotechnological processes are being developed that use cultures of Aspergillus niger and other fungi to transform steroids and flavonoids to a variety of metabolites. These biochemical reactions, including hydroxylation, dehydrogenation, O-methylation, demethylation, cleavage of rings, epoxide hydrolysis, double bond reduction, and others, may be used for the production of higher-value compounds. JF - Applied Biochemistry and Biotechnology AU - Parshikov, Igor A AU - Sutherland, John B AD - Institute of Applied Mechanics, Russian Academy of Sciences, Moscow, 119991, Russia, john.sutherland@fda.hhs.gov Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 903 EP - 923 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 176 IS - 3 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - triterpenoids KW - Epoxides KW - Flavonoids KW - Fungi KW - biotransformation KW - Metabolites KW - Steroid hormones KW - Hydrolysis KW - Phenylalanine KW - Hydroxylation KW - Demethylation KW - Cyclohexane KW - Dehydrogenation KW - Pharmaceuticals KW - Aspergillus niger KW - Aromatics KW - Cyclopentane KW - Squalene KW - W 30950:Waste Treatment & Pollution Clean-up KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709180755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Biotransformation+of+Steroids+and+Flavonoids+by+Cultures+of+Aspergillus+niger&rft.au=Parshikov%2C+Igor+A%3BSutherland%2C+John+B&rft.aulast=Parshikov&rft.aufirst=Igor&rft.date=2015-06-01&rft.volume=176&rft.issue=3&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1007%2Fs12010-015-1619-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 69 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - triterpenoids; Flavonoids; Epoxides; Fungi; biotransformation; Metabolites; Steroid hormones; Phenylalanine; Hydrolysis; Hydroxylation; Demethylation; Cyclohexane; Dehydrogenation; Pharmaceuticals; Aromatics; Squalene; Cyclopentane; Aspergillus niger DO - http://dx.doi.org/10.1007/s12010-015-1619-x ER - TY - JOUR T1 - Metabolic fate of fructose in human adipocytes: a targeted super(13)C tracer fate association study AN - 1709177239; PQ0001590304 AB - The development of obesity is becoming an international problem and the role of fructose is unclear. Studies using liver tissue and hepatocytes have contributed to the understanding of fructose metabolism. Excess fructose consumption also affects extra hepatic tissues including adipose tissue. The effects of fructose on human adipocytes are not yet fully characterized, although in vivo studies have noted increased adiposity and weight gain in response to fructose sweetened-beverages. In order to understand and predict the metabolic responses of adipocytes to fructose, this study examined differentiating and differentiated human adipocytes in culture, exposed to a range of fructose concentrations equivalent to that reported in blood after consuming fructose. A stable isotope based dynamic profiling method using [U- super(13)C sub(6)]-d-fructose tracer was used to examine the metabolism and fate of fructose. A targeted stable isotope tracer fate association method was used to analyze metabolic fluxes and flux surrogates with exposure to escalating fructose concentration. This study demonstrated that fructose stimulates anabolic processes in adipocytes robustly, including glutamate and de novo fatty acid synthesis. Furthermore, fructose also augments the release of free palmitate from fully differentiated adipocytes. These results imply that in the presence of fructose, the metabolic response of adipocytes in culture is altered in a dose dependent manner, particularly favoring increased glutamate and fatty acid synthesis and release, warranting further in vivo studies. JF - Metabolomics AU - Varma, Vijayalakshmi AU - Boros, Laszlo G AU - Nolen, Greg T AU - Chang, Ching-Wei AU - Wabitsch, Martin AU - Beger, Richard D AU - Kaput, Jim AD - Division of Systems Biology, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA, vijayalakshmi.varma@fda.hhs.gov Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 529 EP - 544 PB - OMICS Publishing Group, New York VL - 11 IS - 3 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Obesity KW - Isotopes KW - Hepatocytes KW - Blood KW - Tracers KW - Palmitic acid KW - Adipocytes KW - Fructose KW - Liver KW - Fatty acids KW - Adipose tissue KW - Glutamic acid KW - metabolic flux KW - metabolomics KW - Metabolic response KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709177239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Metabolic+fate+of+fructose+in+human+adipocytes%3A+a+targeted+super%2813%29C+tracer+fate+association+study&rft.au=Varma%2C+Vijayalakshmi%3BBoros%2C+Laszlo+G%3BNolen%2C+Greg+T%3BChang%2C+Ching-Wei%3BWabitsch%2C+Martin%3BBeger%2C+Richard+D%3BKaput%2C+Jim&rft.aulast=Varma&rft.aufirst=Vijayalakshmi&rft.date=2015-06-01&rft.volume=11&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-014-0716-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 70 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Obesity; Isotopes; Hepatocytes; Tracers; Blood; Adipocytes; Palmitic acid; Fructose; Fatty acids; Liver; Adipose tissue; Glutamic acid; metabolomics; metabolic flux; Metabolic response DO - http://dx.doi.org/10.1007/s11306-014-0716-0 ER - TY - JOUR T1 - Evaluation of Level of Agreement in Bordetella Species Identification in Three U.S. Laboratories during a Period of Increased Pertussis AN - 1709175558; PQ0001679729 AB - While PCR is the most common method used for detecting Bordetella pertussis in the United States, most laboratories use insertion sequence 481 (IS481), which is not specific for B. pertussis; therefore, the relative contribution of other Bordetella species is not understood. The objectives of this study were to evaluate the proportion of other Bordetella species misidentified as B. pertussis during a period of increased pertussis incidence, determine the level of agreement in Bordetella species detection between U.S. commercial laboratories and the CDC, and assess the relative diagnostic sensitivity of CDC's PCR assay when using a different PCR master mix. Specimens collected between May 2012 and May 2013 were tested at two U.S. commercial laboratories for B. pertussis and B. parapertussis detection. Every fifth specimen positive for IS481 and/or IS1001 with cycle threshold (CT) values of less than or equal to 35 was sent to CDC for PCR testing that identifies Bordetella species. Specimens with indeterminate or negative results in the CDC PCR were tested using an alternate PCR master mix. Of 755 specimens, there was agreement in species identification for 83.4% (n = 630). Of the specimens with different identifications (n = 125), 79.2% (n = 99) were identified as indeterminate B. pertussis at CDC. Overall, 0.66% (n = 5) of the specimens were identified as B. holmesii or B. bronchiseptica at CDC. Of 115 specimens with indeterminate or negative results, 46.1% (n = 53) were B. pertussis positive when tested by an alternate master mix, suggesting a possible increase in assay sensitivity. This study demonstrates good agreement between the two U.S. commercial laboratories and CDC and little misidentification of Bordetella species during the 2012 U.S. epidemic. JF - Journal of Clinical Microbiology AU - Burgos-Rivera, Brunilis AU - Lee, Adria D AU - Bowden, Katherine E AU - Faulkner, Amanda E AU - Seaton, Brent L AU - Lembke, Bryndon D AU - Cartwright, Charles P AU - Martin, Stacey W AU - Tondella, M Lucia AD - Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia, USA, wri2@cdc.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1842 EP - 1847 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 6 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Pertussis KW - Bordetella pertussis KW - Epidemics KW - Bordetella KW - Polymerase chain reaction KW - Insertion sequences KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709175558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+Level+of+Agreement+in+Bordetella+Species+Identification+in+Three+U.S.+Laboratories+during+a+Period+of+Increased+Pertussis&rft.au=Burgos-Rivera%2C+Brunilis%3BLee%2C+Adria+D%3BBowden%2C+Katherine+E%3BFaulkner%2C+Amanda+E%3BSeaton%2C+Brent+L%3BLembke%2C+Bryndon+D%3BCartwright%2C+Charles+P%3BMartin%2C+Stacey+W%3BTondella%2C+M+Lucia&rft.aulast=Burgos-Rivera&rft.aufirst=Brunilis&rft.date=2015-06-01&rft.volume=53&rft.issue=6&rft.spage=1842&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.03567-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 30 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Pertussis; Epidemics; Polymerase chain reaction; Insertion sequences; Bordetella pertussis; Bordetella DO - http://dx.doi.org/10.1128/JCM.03567-14 ER - TY - JOUR T1 - Successful Combination of Nucleic Acid Amplification Test Diagnostics and Targeted Deferred Neisseria gonorrhoeae Culture AN - 1709172856; PQ0001679704 AB - Nucleic acid amplification tests (NAATs) are recommended for the diagnosis of N. gonorrhoeae infections because of their superior sensitivity. Increasing NAAT use causes a decline in crucial antimicrobial resistance (AMR) surveillance data, which rely on culture. We analyzed the suitability of the ESwab system for NAAT diagnostics and deferred targeted N. gonorrhoeae culture to allow selective and efficient culture based on NAAT results. We included patients visiting the STI Clinic Amsterdam, The Netherlands, in 2013. Patient characteristics and urogenital and rectal samples for direct N. gonorrhoeae culture, standard NAAT, and ESwab were collected. Standard NAAT and NAAT on ESwab samples were performed using the Aptima Combo 2 assay for N. gonorrhoeae and C. trachomatis. Two deferred N. gonorrhoeae cultures were performed on NAAT-positive ESwab samples after storage at 4 degree C for 1 to 3 days. We included 2,452 samples from 1,893 patients. In the standard NAAT, 107 samples were N. gonorrhoeae positive and 284 were C. trachomatis positive. The sensitivities of NAAT on ESwab samples were 83% (95% confidence interval [CI], 75 to 90%) and 87% (95% CI, 82 to 90%), respectively. ESwab samples were available for 98 of the gonorrhea-positive samples. Of these, 82% were positive in direct culture and 69% and 56% were positive in the 1st and 2nd deferred cultures, respectively (median storage times, 27 and 48 h, respectively). Deferred culture was more often successful in urogenital samples or when the patient had symptoms at the sampling site. Deferred N. gonorrhoeae culture of stored ESwab samples is feasible and enables AMR surveillance. To limit the loss in NAAT sensitivity, we recommend obtaining separate samples for NAAT and deferred culture. JF - Journal of Clinical Microbiology AU - Wind, Carolien M AU - de Vries, Henry JC AU - Schim van der, Maarten F AU - Unemo, Magnus AU - van Dam, Alje P AD - STI Outpatient Clinic, Cluster of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands, avdam@ggd.amsterdam.nl. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1884 EP - 1890 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 6 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - nucleic acids KW - Data processing KW - Rectum KW - Drug resistance KW - Sampling KW - Infection KW - Neisseria gonorrhoeae KW - J 02400:Human Diseases KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709172856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Successful+Combination+of+Nucleic+Acid+Amplification+Test+Diagnostics+and+Targeted+Deferred+Neisseria+gonorrhoeae+Culture&rft.au=Wind%2C+Carolien+M%3Bde+Vries%2C+Henry+JC%3BSchim+van+der%2C+Maarten+F%3BUnemo%2C+Magnus%3Bvan+Dam%2C+Alje+P&rft.aulast=Wind&rft.aufirst=Carolien&rft.date=2015-06-01&rft.volume=53&rft.issue=6&rft.spage=1884&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00369-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 29 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Rectum; Data processing; nucleic acids; Drug resistance; Sampling; Infection; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1128/JCM.00369-15 ER - TY - JOUR T1 - Invited debate: Response to Capewell et al. AN - 1707500904 JF - Journal of Public Health AU - Greaves, Felix AU - Gresser, Charis AU - Kearney, Matt AU - Fenton, Kevin A AD - Waterall, Jamie; Address correspondence to Jamie Waterall, E-mail: Jamie.Waterall@phe.gov.uk Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 193 EP - 194 CY - Oxford PB - Oxford Publishing Limited(England) VL - 37 IS - 2 SN - 1741-3842 KW - Social Services And Welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707500904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health&rft.atitle=Invited+debate%3A+Response+to+Capewell+et+al.&rft.au=Waterall%2C+Jamie%3BGreaves%2C+Felix%3BGresser%2C+Charis%3BKearney%2C+Matt%3BFenton%2C+Kevin+A&rft.aulast=Waterall&rft.aufirst=Jamie&rft.date=2015-06-01&rft.volume=37&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health&rft.issn=17413842&rft_id=info:doi/10.1093%2Fpubmed%2Ffdv065 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-09-22 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.1093/pubmed/fdv065 ER - TY - JOUR T1 - The per case and total annual costs of foodborne illness in the United States AN - 1704340812; 4695064 AB - We present an economic welfare-based method to estimate the health costs associated with foodborne illness caused by known viruses, bacteria, parasites, allergens, two marine biotoxins, and unspecified agents. The method generates health costs measured in both quality-adjusted life years and in dollars. We calculate the reduction in quality-adjusted life days caused by the illness and add reductions in quality-adjusted life years from any secondary effects that are estimated to occur. For fatal cases, we calculate the life years lost due to premature death. We add direct medical expenses to the monetary costs as derived from estimates of willingness to pay to reduce health risks. In total, we estimate that foodborne illness represents an annual burden to society of approximately $36 billion, with an average identified illness estimated to reduce quality-adjusted life days by 0.84, which is monetized and included in the average cost burden per illness of $3,630. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Brown, Bradley AU - Nardinelli, Clark AU - Zorn, David AU - Minor, Travis AU - Lasher, Angela AU - Klontz, Karl AD - US Food and Drug Administration Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 1125 EP - 1139 VL - 35 IS - 6 SN - 0272-4332, 0272-4332 KW - Economics KW - Health expenditure KW - Welfare economics KW - U.S.A. KW - Willingness-to-pay KW - Illness KW - Adjustment costs KW - Quality of life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704340812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=The+per+case+and+total+annual+costs+of+foodborne+illness+in+the+United+States&rft.au=Brown%2C+Bradley%3BNardinelli%2C+Clark%3BZorn%2C+David%3BMinor%2C+Travis%3BLasher%2C+Angela%3BKlontz%2C+Karl&rft.aulast=Brown&rft.aufirst=Bradley&rft.date=2015-06-01&rft.volume=35&rft.issue=6&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Frisa.12316 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - 6220; 5780 4618; 10525 12162 3898; 13567 13219 13221; 564 2934; 13525 4019; 433 293 14 DO - http://dx.doi.org/10.1111/risa.12316 ER - TY - JOUR T1 - Seasonal Dynamics and Habitat Specificity of Mosquitoes in an English Wetland: Implications for UK Wetland Management and Restoration AN - 1701483629; PQ0001667249 AB - We engaged in field studies of native mosquitoes in a Cambridgeshire Fen, investigating a) the habitat specificity and seasonal dynamics of our native fauna in an intensively managed wetland, b) the impact of water-level and ditch management, and c) their colonization of an arable reversion to flooded grassland wetland expansion project. Studies from April to October, 2010 collected 14,000 adult mosquitoes (15 species) over 292 trap-nights and similar to 4,000 pre-imaginal mosquitoes (11 species). Open floodwater species (Aedes caspius and Aedes cinereus, 43.3%) and wet woodland species (Aedes cantans/annulipes and Aedes rusticus, 32.4%) dominated, highlighting the major impact of seasonal water-level management on mosquito populations in an intensively managed wetland. In permanent habitats, managing marginal ditch vegetation and ditch drying significantly affect densities of pre-imaginal anophelines and culicines, respectively. This study presents the first UK field evidence of the implications of wetland expansion through arable reversion on mosquito colonization. Understanding the heterogeneity of mosquito diversity, phenology, and abundance in intensively managed UK wetlands will be crucial to mitigating nuisance and vector species through habitat management and biocidal control. JF - Journal of Vector Ecology AU - Medlock, Jolyon M AU - Vaux, Alexander GC AD - Medical Entomology and Zoonoses Ecology Group, MRA, Emergency Response Department, Public Health England, Porton Down, Salisbury, United Kingdom, jolyon.medlock@phe.gov.uk Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 90 EP - 106 PB - Society for Vector Ecology VL - 40 IS - 1 SN - 1081-1710, 1081-1710 KW - Entomology Abstracts; Ecology Abstracts KW - Wetlands KW - ecology KW - mosquitoes KW - Anopheles KW - Aedes KW - Culex KW - Aedes rusticus KW - Abundance KW - Vectors KW - Reversion KW - Drying KW - Vegetation KW - Habitat KW - Colonization KW - Grasslands KW - Phenology KW - Aedes caspius KW - Aedes cinereus KW - Z 05340:Ecology and Behavior KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701483629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Vector+Ecology&rft.atitle=Seasonal+Dynamics+and+Habitat+Specificity+of+Mosquitoes+in+an+English+Wetland%3A+Implications+for+UK+Wetland+Management+and+Restoration&rft.au=Medlock%2C+Jolyon+M%3BVaux%2C+Alexander+GC&rft.aulast=Medlock&rft.aufirst=Jolyon&rft.date=2015-06-01&rft.volume=40&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+Vector+Ecology&rft.issn=10811710&rft_id=info:doi/10.1111%2Fjvec.12137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 43 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Grasslands; Colonization; Phenology; Abundance; Vegetation; Drying; Reversion; Vectors; Wetlands; Habitat; Aedes rusticus; Aedes; Aedes cinereus; Aedes caspius DO - http://dx.doi.org/10.1111/jvec.12137 ER - TY - JOUR T1 - Dose-response assessment of the dermal toxicity of triclosan in B6C3F1 mice AN - 1701482987; PQ0001703913 AB - Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol] is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive life-time exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. The present study evaluated the toxicity of triclosan administered dermally to B6C3F1 mice for 13 weeks. Groups of 10 male and 10 female B6C3F1 mice received dermal applications of 0, 5.8, 12.5, 27, 58, or 125 mg triclosan per kg body weight (bw) daily for 13 weeks. The doses were administered in 1 ml ethanol per kg bw. All mice survived the 13-week treatment period. Body weights of female mice receiving 125 mg triclosan per kg bw per day weighed 94% (p< 0.05) of the female control mice; male mice administered 58 and 125 mg triclosan per kg bw per day weighed 91% (p< 0.05) and 82% (p< 0.01) of the control male mice. Liver weights were significantly increased in females receiving 58 and 125 mg triclosan per kg bw per day and in males in the 125 mg triclosan per kg bw per day dose group. A significant dose-dependent decrease in the levels of thyroxine and cholesterol was observed in both sexes. The highest dose of triclosan increased the percentage of reticulocytes in both sexes; in addition, the 58 mg triclosan per kg bw per day dose increased the percentage of reticulocytes in females. Skin lesions (dermal fibrosis and inflammation; epidermal hyperplasia, inflammation, necrosis, and ulceration, and parakeratosis) were observed in both sexes, with a dose-dependent increase in severity and incidence. JF - Toxicology Research AU - Fang, Jia-Long AU - M Vanlandingham, Michelle AU - Juliar, Beth E AU - R Olson, Greg AU - E Patton, Ralph AU - Beland, Frederick A AD - Division of Biochemical Toxicology; National Center for Toxicological Research; Jefferson; Arkansas 72079; USA; +870-543-7136; +870-543-7612; , jia-long.fang@fda.hhs.gov Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 867 EP - 877 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 4 IS - 4 SN - 2045-452X, 2045-452X KW - Toxicology Abstracts KW - Age KW - Data processing KW - Skin KW - Fibrosis KW - Toxicity KW - Cholesterol KW - Inflammation KW - Antimicrobial agents KW - Hyperplasia KW - Necrosis KW - Body weight KW - Skin diseases KW - Carcinogenicity KW - Liver KW - Thyroxine KW - Reticulocytes KW - Triclosan KW - Ethanol KW - Sex KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701482987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Research&rft.atitle=Dose-response+assessment+of+the+dermal+toxicity+of+triclosan+in+B6C3F1+mice&rft.au=Fang%2C+Jia-Long%3BM+Vanlandingham%2C+Michelle%3BJuliar%2C+Beth+E%3BR+Olson%2C+Greg%3BE+Patton%2C+Ralph%3BBeland%2C+Frederick+A&rft.aulast=Fang&rft.aufirst=Jia-Long&rft.date=2015-06-01&rft.volume=4&rft.issue=4&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=Toxicology+Research&rft.issn=2045452X&rft_id=info:doi/10.1039%2Fc4tx00152d LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 51 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Age; Skin; Data processing; Fibrosis; Cholesterol; Toxicity; Antimicrobial agents; Inflammation; Necrosis; Hyperplasia; Skin diseases; Body weight; Carcinogenicity; Thyroxine; Liver; Triclosan; Reticulocytes; Sex; Ethanol DO - http://dx.doi.org/10.1039/c4tx00152d ER - TY - JOUR T1 - Towards early inclusion of children in tuberculosis drugs trials: a consensus statement. AN - 1698956884; 25957923 AB - Children younger than 18 years account for a substantial proportion of patients with tuberculosis worldwide. Available treatments for paediatric drug-susceptible and drug-resistant tuberculosis, albeit generally effective, are hampered by high pill burden, long duration of treatment, coexistent toxic effects, and an overall scarcity of suitable child-friendly formulations. Several new drugs and regimens with promising activity against both drug-susceptible and drug-resistant strains have entered clinical development and are either in various phases of clinical investigation or have received marketing authorisation for adults; however, none have data on their use in children. This consensus statement, generated from an international panel of opinion leaders on childhood tuberculosis and incorporating reviews of published literature from January, 2004, to May, 2014, addressed four key questions: what drugs or regimens should be prioritised for clinical trials in children? Which populations of children are high priorities for study? When can phase 1 or 2 studies be initiated in children? What are the relevant elements of clinical trial design? The consensus panel found that children can be included in studies at the early phases of drug development and should be an integral part of the clinical development plan, rather than studied after regulatory approval in adults is obtained. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - The Lancet. Infectious diseases AU - Nachman, Sharon AU - Ahmed, Amina AU - Amanullah, Farhana AU - Becerra, Mercedes C AU - Botgros, Radu AU - Brigden, Grania AU - Browning, Renee AU - Gardiner, Elizabeth AU - Hafner, Richard AU - Hesseling, Anneke AU - How, Cleotilde AU - Jean-Philippe, Patrick AU - Lessem, Erica AU - Makhene, Mamodikoe AU - Mbelle, Nontombi AU - Marais, Ben AU - McIlleron, Helen AU - McNeeley, David F AU - Mendel, Carl AU - Murray, Stephen AU - Navarro, Eileen AU - Anyalechi, E Gloria AU - Porcalla, Ariel R AU - Powell, Clydette AU - Powell, Mair AU - Rigaud, Mona AU - Rouzier, Vanessa AU - Samson, Pearl AU - Schaaf, H Simon AU - Shah, Seema AU - Starke, Jeff AU - Swaminathan, Soumya AU - Wobudeya, Eric AU - Worrell, Carol AD - SUNY at Stony Brook, Stony Brook, NY, USA. Electronic address: sharon.nachman@stonybrook.edu. ; Levine Children's Hospital at Carolinas Medical Center, Charlotte, NC, USA. ; Indus Hospital, Pakistan. ; Harvard Medical School, Boston, MA, USA. ; European Medicines Agency, London, UK. ; Médecins Sans Frontières, Access Campaign, Geneva, Switzerland. ; National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of AIDS, Bethesda, MD, USA. ; TB Alliance, New York, NY, USA. ; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa. ; Department of Pharmacology and Toxicology, University of the Philippines, Manila, Philippines. ; Henry M Jackson Foundation-Division of AIDS, Contractor to National Institutes of Health, National Institute of Allergy and Infectious Diseases, Department of Health and Human Services, Bethesda, MD, USA. ; Treatment Action Group, New York, NY, USA. ; Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa. ; Marie Bashir Institute for Infectious Diseases and Biosecurity and the Sydney Emerging Infectious Diseases and Biosecurity Institute and The Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia. ; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa. ; Novartis Pharmaceuticals, East Hanover, NJ, USA. ; Division of Anti-Infective Products; Office of Antimicrobial Products, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. ; US Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, International Research and Programs Branch, Atlanta, GA, USA. ; US Agency for International Development, Washington, DC, USA. ; New York University School of Medicine, NY, USA. ; GHESKIO, Port-au-Prince, Haiti. ; Statistical and Data Analysis Center, Center for Biostatistics in AIDS Research and Frontier Science, Harvard School of Public Health, Boston, MA, USA. ; Department of Bioethics, NIH Clinical Center, Bethesda, MD, USA. ; Baylor College of Medicine, Houston, TX, USA. ; National Institute for Research in Tuberculosis, Chennai, India. ; Makerere University Johns Hopkins Research Collaboration, and Mulago National Referral Hospital, Kampala, Uganda. ; Eunice Kennedy Schriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 711 EP - 720 VL - 15 IS - 6 KW - Antitubercular Agents KW - 0 KW - Index Medicus KW - Infant KW - Age Factors KW - Humans KW - Adult KW - Infant, Newborn KW - Consensus KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Tuberculosis -- drug therapy KW - Clinical Trials as Topic KW - Antitubercular Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698956884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Lancet.+Infectious+diseases&rft.atitle=Towards+early+inclusion+of+children+in+tuberculosis+drugs+trials%3A+a+consensus+statement.&rft.au=Nachman%2C+Sharon%3BAhmed%2C+Amina%3BAmanullah%2C+Farhana%3BBecerra%2C+Mercedes+C%3BBotgros%2C+Radu%3BBrigden%2C+Grania%3BBrowning%2C+Renee%3BGardiner%2C+Elizabeth%3BHafner%2C+Richard%3BHesseling%2C+Anneke%3BHow%2C+Cleotilde%3BJean-Philippe%2C+Patrick%3BLessem%2C+Erica%3BMakhene%2C+Mamodikoe%3BMbelle%2C+Nontombi%3BMarais%2C+Ben%3BMcIlleron%2C+Helen%3BMcNeeley%2C+David+F%3BMendel%2C+Carl%3BMurray%2C+Stephen%3BNavarro%2C+Eileen%3BAnyalechi%2C+E+Gloria%3BPorcalla%2C+Ariel+R%3BPowell%2C+Clydette%3BPowell%2C+Mair%3BRigaud%2C+Mona%3BRouzier%2C+Vanessa%3BSamson%2C+Pearl%3BSchaaf%2C+H+Simon%3BShah%2C+Seema%3BStarke%2C+Jeff%3BSwaminathan%2C+Soumya%3BWobudeya%2C+Eric%3BWorrell%2C+Carol&rft.aulast=Nachman&rft.aufirst=Sharon&rft.date=2015-06-01&rft.volume=15&rft.issue=6&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=The+Lancet.+Infectious+diseases&rft.issn=1474-4457&rft_id=info:doi/10.1016%2FS1473-3099%2815%2900007-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-03 N1 - Date created - 2015-05-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2012 Nov 15;186(10):953-64 [22983960] Int J Tuberc Lung Dis. 2012 Dec;16(12):1588-93 [23032215] Pediatr Infect Dis J. 2013 Sep;32(9):972-7 [23503163] MMWR Recomm Rep. 2013 Oct 25;62(RR-09):1-12 [24157696] Int J Tuberc Lung Dis. 2013 Dec;17(12):1518-23 [24200262] BMC Infect Dis. 2013;13:392 [23977834] Clin Infect Dis. 2013 Dec;57(12):1676-84 [24065321] J Chemother. 2014 Feb;26(1):1-12 [24090489] Proc Am Thorac Soc. 2007 May;4(2):176-8, discussion 178-9 [17494727] Paediatr Respir Rev. 2007 Jun;8(2):142-7 [17574158] J Infect Dis. 2007 Aug 15;196 Suppl 1:S76-85 [17624829] PLoS Med. 2008 Aug 19;5(8):e176 [18715115] Clin Infect Dis. 2009 Jan 1;48(1):108-14 [19049436] Int J Tuberc Lung Dis. 2009 Jul;13(7):862-7 [19555536] Am J Public Health. 2009 Aug;99(8):1486-90 [19197080] Crit Care Med. 2009 Sep;37(9):2638-41 [19602971] Clin Chest Med. 2009 Dec;30(4):667-83, vii-viii [19925960] N Engl J Med. 2003 Sep 18;349(12):1157-67 [13679531] Eur J Pediatr. 2004 Feb;163(2):53-7 [14716559] Lancet Infect Dis. 2010 Nov;10(11):803-12 [20822958] J Clin Pharmacol. 2010 Dec;50(12):1377-87 [20150527] Paediatr Respir Rev. 2011 Mar;12(1):39-45 [21172674] Indian J Pediatr. 2011 Apr;78(4):456-63 [21193973] Arch Dis Child. 2011 Jun;96(6):560-4 [21310895] Scand J Infect Dis. 2011 Jul;43(6-7):556-9 [21391771] Int J Tuberc Lung Dis. 2011 Sep;15(9):1191-3, i [21943844] Pediatrics. 2011 Nov;128(5):e1242-9 [22025597] Antimicrob Agents Chemother. 2011 Dec;55(12):5560-7 [21968358] N Engl J Med. 2011 Dec 8;365(23):2155-66 [22150035] Int J Tuberc Lung Dis. 2012 Jan;16(1):76-81 [22236850] Int J Tuberc Lung Dis. 2012 Feb;16(2):196-202 [22236920] Tuberculosis (Edinb). 2012 Jan;92(1):9-17 [22118883] J Infect Dis. 2012 May 15;205 Suppl 2:S199-208 [22448023] Eur J Med Chem. 2012 May;51:1-16 [22421275] N Engl J Med. 2012 Jun 7;366(23):2151-60 [22670901] Pediatr Infect Dis J. 2012 Jul;31(7):711-6 [22411053] Int J Tuberc Lung Dis. 2012 Apr;16(4):447-54 [22325685] Clin Infect Dis. 2012 Aug;55(4):572-81 [22615332] N Engl J Med. 2012 Jul 26;367(4):348-61 [22830465] Pediatrics. 2012 Aug;130(2):e373-9 [22826566] Trop Med Int Health. 2012 Jan;17(1):52-8 [21967134] N Engl J Med. 2012 Oct 18;367(16):1508-18 [23075177] Eur Respir J. 2013 Sep;42(3):701-7 [23222872] Expert Opin Investig Drugs. 2013 Jul;22(7):927-32 [23687915] Clin Dev Immunol. 2013;2013:781320 [23762096] Eur Respir J. 2013 Jun;41(6):1393-400 [23018916] Int J Tuberc Lung Dis. 2013 Jun;17(6):794-9 [23676164] Nat Rev Drug Discov. 2013 May;12(5):388-404 [23629506] Int J Tuberc Lung Dis. 2013 May;17(5):624-9 [23575328] Lancet Infect Dis. 2013 Apr;13(4):287-9 [23531386] J Infect. 2013 Apr;66(4):320-9 [22960077] J Infect Dis. 2012 Dec 15;206(12):1809-15 [23033147] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/S1473-3099(15)00007-9 ER - TY - JOUR T1 - Acrylamide-induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks AN - 1694974463; PQ0001664186 AB - Potential health risks for humans from exposure to acrylamide (AA) and its epoxide metabolite glycidamide (GA) have garnered much attention lately because substantial amounts of AA are present in a variety of fried and baked starchy foods. AA is tumorigenic in rodents, and a large number of in vitro and in vivo studies indicate that AA is genotoxic. A recent cancer bioassay on AA demonstrated that the lung was one of the target organs for tumor induction in mice; however, the mutagenicity of AA in this tissue is unclear. Therefore, to investigate whether or not gene mutation is involved in the etiology of AA- or GA-induced mouse lung carcinogenicity, we screened for cII mutant frequency (MF) in lungs from male and female Big Blue (BB) mice administered 0, 1.4, and 7.0 mM AA or GA in drinking water for up to 4 weeks (19-111 mg/kg bw/days). Both doses of AA and GA produced significant increases in cII MFs, with the high doses producing responses 2.7-5.6-fold higher than the corresponding controls (P less than or equal to 0.05; control MFs=17.2 plus or minus 2.2 and 15.8 plus or minus 3.5 x 10 super(-6) in males and females, respectively). Molecular analysis of the mutants from high doses indicated that AA and GA produced similar mutation spectra and that these spectra were significantly different from the spectra in control mice (P less than or equal to 0.01). The predominant types of mutations in the lung cII gene from AA- and GA-treated mice were A:T arrow right T:A, and G:C arrow right C:G transversions, and -1/+1 frameshifts at a homopolymeric run of Gs. The MFs and types of mutations induced by AA and GA in the lung are consistent with AA exerting its genotoxicity via metabolism to GA. These results suggest that AA is a mutagenic carcinogen in mouse lungs and therefore further studies on its potential health risk to humans are warranted. Environ. Mol. Mutagen. 56:446-456, 2015. JF - Environmental and Molecular Mutagenesis AU - Manjanatha, Mugimane G AU - Guo, Li-Wu AU - Shelton, Sharon D AU - Doerge, Daniel R AD - Division of Genetic and Molecular Toxicology, US FDA, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 446 EP - 456 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 56 IS - 5 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Genetics Abstracts KW - Mutagens KW - Epoxides KW - Food KW - Metabolites KW - Mutant frequency KW - Carcinogens KW - Transversion KW - Mutants KW - Mutagenesis KW - Carcinogenicity KW - Mutagenicity KW - Etiology KW - Genotoxicity KW - Point mutation KW - Mice KW - Tumors KW - Cancer KW - Health risks KW - Bioassays KW - Acrylamide KW - Lung KW - Drinking water KW - Mutation KW - Metabolism KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694974463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Acrylamide-induced+carcinogenicity+in+mouse+lung+involves+mutagenicity%3A+cII+gene+mutations+in+the+lung+of+big+blue+mice+exposed+to+acrylamide+and+glycidamide+for+up+to+4+weeks&rft.au=Manjanatha%2C+Mugimane+G%3BGuo%2C+Li-Wu%3BShelton%2C+Sharon+D%3BDoerge%2C+Daniel+R&rft.aulast=Manjanatha&rft.aufirst=Mugimane&rft.date=2015-06-01&rft.volume=56&rft.issue=5&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.21939 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Mutagens; Etiology; Mutagenicity; Epoxides; Food; Point mutation; Genotoxicity; Mutant frequency; Metabolites; Carcinogens; Tumors; Cancer; Transversion; Mutagenesis; Acrylamide; Lung; Carcinogenicity; Drinking water; Metabolism; Mice; Mutants; Health risks; Bioassays; Mutation DO - http://dx.doi.org/10.1002/em.21939 ER - TY - JOUR T1 - Data Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson Syndrome. AN - 1689843805; 25876064 AB - Drug features that are associated with Stevens-Johnson syndrome (SJS) have not been fully characterized. A molecular target analysis of the drugs associated with SJS in the FDA Adverse Event Reporting System (FAERS) may contribute to mechanistic insights into SJS pathophysiology. The publicly available version of FAERS was analyzed to identify disproportionality among the molecular targets, metabolizing enzymes, and transporters for drugs associated with SJS. The FAERS in-house version was also analyzed for an internal comparison of the drugs most highly associated with SJS. Cyclooxygenases 1 and 2, carbonic anhydrase 2, and sodium channel 2 alpha were identified as disproportionately associated with SJS. Cytochrome P450 (CYPs) 3A4 and 2C9 are disproportionately represented as metabolizing enzymes of the drugs associated with SJS adverse event reports. Multidrug resistance protein 1 (MRP-1), organic anion transporter 1 (OAT1), and PEPT2 were also identified and are highly associated with the transport of these drugs. A detailed review of the molecular targets identifies important roles for these targets in immune response. The association with CYP metabolizing enzymes suggests that reactive metabolites and oxidative stress may have a contributory role. Drug transporters may enhance intracellular tissue concentrations and also have vital physiologic roles that impact keratinocyte proliferation and survival. Data mining FAERS may be used to hypothesize mechanisms for adverse drug events by identifying molecular targets that are highly associated with drug-induced adverse events. The information gained may contribute to systems biology disease models. JF - Journal of medical toxicology : official journal of the American College of Medical Toxicology AU - Burkhart, Keith K AU - Abernethy, Darrell AU - Jackson, David AD - Medical Informatics Team, Office of Clinical Pharmacology, Office of Translational Science, Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, Bldg 64, Rm 2012, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA, keith.burkhart@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 265 EP - 273 VL - 11 IS - 2 KW - Carrier Proteins KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - United States KW - Cell Proliferation -- drug effects KW - Software KW - United States Food and Drug Administration KW - Cytochrome P-450 Enzyme System -- genetics KW - Keratinocytes -- drug effects KW - Humans KW - Carrier Proteins -- genetics KW - Incidence KW - Cytochrome P-450 Enzyme System -- metabolism KW - Structure-Activity Relationship KW - Genes, MHC Class II KW - Stevens-Johnson Syndrome -- therapy KW - Stevens-Johnson Syndrome -- epidemiology KW - Adverse Drug Reaction Reporting Systems KW - Data Mining -- methods KW - Stevens-Johnson Syndrome -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689843805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.atitle=Data+Mining+FAERS+to+Analyze+Molecular+Targets+of+Drugs+Highly+Associated+with+Stevens-Johnson+Syndrome.&rft.au=Burkhart%2C+Keith+K%3BAbernethy%2C+Darrell%3BJackson%2C+David&rft.aulast=Burkhart&rft.aufirst=Keith&rft.date=2015-06-01&rft.volume=11&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.issn=1937-6995&rft_id=info:doi/10.1007%2Fs13181-015-0472-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-22 N1 - Date created - 2015-06-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Pharm Pharmacol. 2008 May;60(5):543-85 [18416933] Bioorg Med Chem. 2008 Aug 1;16(15):7424-8 [18579385] J Pharm Biomed Anal. 2008 Sep 10;48(1):92-9 [18584988] Pain. 2008 Sep 30;139(1):90-105 [18442883] Am J Respir Cell Mol Biol. 2008 Nov;39(5):536-42 [18474668] J Chromatogr A. 2008 Oct 24;1208(1-2):164-74 [18778828] Drug Metab Dispos. 2009 Feb;37(2):247-53 [19005027] Xenobiotica. 2009 Jan;39(1):11-21 [19219744] Pharm Res. 2009 Apr;26(4):822-35 [19082874] Regul Toxicol Pharmacol. 2009 Jun;54(1):1-22 [19422096] Curr Opin Allergy Clin Immunol. 2009 Aug;9(4):311-5 [19535973] Expert Opin Drug Metab Toxicol. 2009 Aug;5(8):887-905 [19519280] Nature. 2009 Nov 12;462(7270):175-81 [19881490] Chem Res Toxicol. 2010 Jan;23(1):159-70 [19961160] Am J Health Syst Pharm. 2010 Feb 1;67(3):206-13 [20101062] Rapid Commun Mass Spectrom. 2010 May 30;24(10):1447-56 [20411584] Drug Metab Dispos. 2010 Jun;38(6):923-9 [20304965] J Pharmacol Exp Ther. 2010 Aug;334(2):609-18 [20484152] Br J Pharmacol. 2010 Sep;161(1):229-40 [20718752] Allergol Int. 2010 Dec;59(4):325-32 [20962567] Orphanet J Rare Dis. 2010;5:39 [21162721] Br J Dermatol. 2010 Jun;162(6):1302-15 [20128793] J Allergy Clin Immunol. 2011 Mar;127(3 Suppl):S74-81 [21354503] Yakugaku Zasshi. 2011;131(5):809-15 [21532277] Drug Metab Dispos. 2011 Jun;39(6):1014-21 [21383205] Am J Reprod Immunol. 2011 Oct;66(4):297-303 [21244564] Biochem Soc Trans. 2011 Oct;39(5):1353-8 [21936814] Clin Pharmacol Ther. 2011 Nov;90(5):662-5 [21975349] Ann Rheum Dis. 2012 Jan;71(1):20-5 [22039164] Arch Dermatol Res. 2012 Jan;304(1):57-63 [21922333] Annu Rev Pharmacol Toxicol. 2012;52:401-31 [22017685] J Allergy Clin Immunol. 2012 Jun;129(6):1562-9.e5 [22322005] AIDS. 2012 Jul 17;26(11):F21-9 [22617051] J Enzyme Inhib Med Chem. 2012 Oct;27(5):641-5 [21851212] Am J Respir Cell Mol Biol. 2013 Feb;48(2):230-9 [23239496] J Cell Sci. 2013 May 1;126(Pt 9):1942-51 [23447677] Pharmacol Res. 2000 Aug;42(2):187-191 [10887051] Eur J Clin Pharmacol. 2002 Apr;58(1):69-72 [11956677] Pharmacoepidemiol Drug Saf. 2002 Jan-Feb;11(1):3-10 [11998548] Int J Colorectal Dis. 2002 Sep;17(5):317-26 [12172925] Life Sci. 2003 Apr 25;72(23):2581-90 [12672504] Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42 [12920490] Eur J Dermatol. 2003 Sep-Oct;13(5):440-4 [14693486] J Rheumatol. 2004 Mar;31(3):436-41 [14994385] Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):402-9 [6528810] Arzneimittelforschung. 1986 Sep;36(9):1417-20 [3790196] Xenobiotica. 1991 Oct;21(10):1281-8 [1686692] J Chromatogr. 1993 Jun 23;616(1):79-85 [7690764] J Biol Chem. 1995 Sep 1;270(35):20668-76 [7657646] Clin Pharmacokinet. 1998 Dec;35(6):425-36 [9884815] Mol Pharmacol. 1999 May;55(5):847-54 [10220563] J Cell Sci. 1999 Oct;112 ( Pt 19):3343-52 [10504339] J Pharmacol Exp Ther. 2004 Dec;311(3):1131-7 [15292462] Drug Saf. 2005;28(10):917-24 [16180941] Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15247-52 [16217040] Am J Physiol Renal Physiol. 2006 Feb;290(2):F251-61 [16403838] Pharmacogenet Genomics. 2006 Apr;16(4):297-306 [16538176] Ther Drug Monit. 2007 Feb;29(1):118-21 [17304159] J Biochem. 2007 Mar;141(3):429-41 [17298961] Blood. 2007 Apr 15;109(8):3608-9 [17409346] J Invest Dermatol. 2007 May;127(5):1145-53 [17124504] Drug Metab Pharmacokinet. 2007 Apr;22(2):103-12 [17495417] Curr Top Med Chem. 2007;7(9):885-91 [17504133] J Invest Dermatol. 2007 Jul;127(7):1786-9 [17363915] J Pharmacol Exp Ther. 2007 Sep;322(3):1208-20 [17556636] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s13181-015-0472-1 ER - TY - JOUR T1 - A review of nonoccupational pathways for pesticide exposure in women living in agricultural areas. AN - 1685752215; 25636067 AB - Women living in agricultural areas may experience high pesticide exposures compared with women in urban or suburban areas because of their proximity to farm activities. Our objective was to review the evidence in the published literature for the contribution of nonoccupational pathways of pesticide exposure in women living in North American agricultural areas. We evaluated the following nonoccupational exposure pathways: paraoccupational (i.e., take-home or bystander exposure), agricultural drift, residential pesticide use, and dietary ingestion. We also evaluated the role of hygiene factors (e.g., house cleaning, shoe removal). Among 35 publications identified (published 1995-2013), several reported significant or suggestive (p < 0.1) associations between paraoccupational (n = 19) and agricultural drift (n = 10) pathways and pesticide dust or biomarker levels, and 3 observed that residential use was associated with pesticide concentrations in dust. The 4 studies related to ingestion reported low detection rates of most pesticides in water; additional studies are needed to draw conclusions about the importance of this pathway. Hygiene factors were not consistently linked to exposure among the 18 relevant publications identified. Evidence supported the importance of paraoccupational, drift, and residential use pathways. Disentangling exposure pathways was difficult because agricultural populations are concurrently exposed to pesticides via multiple pathways. Most evidence was based on measurements of pesticides in residential dust, which are applicable to any household member and are not specific to women. An improved understanding of nonoccupational pesticide exposure pathways in women living in agricultural areas is critical for studying health effects in women and for designing effective exposure-reduction strategies. JF - Environmental health perspectives AU - Deziel, Nicole C AU - Friesen, Melissa C AU - Hoppin, Jane A AU - Hines, Cynthia J AU - Thomas, Kent AU - Freeman, Laura E Beane AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 515 EP - 524 VL - 123 IS - 6 KW - Environmental Pollutants KW - 0 KW - Pesticides KW - Index Medicus KW - Agriculture KW - North America KW - Humans KW - Female KW - Pesticides -- metabolism KW - Environmental Pollutants -- metabolism KW - Environmental Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1685752215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+review+of+nonoccupational+pathways+for+pesticide+exposure+in+women+living+in+agricultural+areas.&rft.au=Deziel%2C+Nicole+C%3BFriesen%2C+Melissa+C%3BHoppin%2C+Jane+A%3BHines%2C+Cynthia+J%3BThomas%2C+Kent%3BFreeman%2C+Laura+E+Beane&rft.aulast=Deziel&rft.aufirst=Nicole&rft.date=2015-06-01&rft.volume=123&rft.issue=6&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408273 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-24 N1 - Date created - 2015-06-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2010 Oct;118(10):1355-62 [20562050] Environ Health Perspect. 2011 Jul;119(7):970-6 [21330232] J Toxicol Environ Health A. 2005 Aug 13;68(15):1359-70 [16020195] Rev Environ Health. 2005 Apr-Jun;20(2):77-101 [16121832] Environ Health Perspect. 2005 Dec;113(12):1802-7 [16330368] J Occup Environ Med. 2011 Aug;53(8):884-91 [21775902] J Environ Qual. 2012 Mar-Apr;41(2):479-94 [22370411] J Occup Environ Hyg. 2012;9(5):289-97 [22506545] Environ Res. 2012 Aug;117:8-16 [22683313] J Occup Environ Med. 2012 Sep;54(9):1163-9 [22772953] Arch Environ Contam Toxicol. 2001 Jul;41(1):112-6 [11385597] Environ Res. 2000 Nov;84(3):290-302 [11097803] Environ Health Perspect. 2013 May;121(5):565-71 [23462689] Environ Health Perspect. 2001 May;109(5):533-8 [11401767] Environ Health Perspect. 2002 May;110(5):549-53 [12003762] J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Oct 5;778(1-2):5-29 [12376114] Environ Health Perspect. 2002 Dec;110(12):A787-92 [12460819] J Toxicol Environ Health A. 2003 Jan 24;66(2):103-32 [12653018] AAOHN J. 2003 Mar;51(3):113-9 [12670098] Environ Health Perspect. 2004 Feb;112(2):142-7 [14754567] Environ Health Perspect. 2004 Mar;112(3):321-6 [14998747] Environ Health Perspect. 2004 Mar;112(3):382-7 [14998757] Am J Ind Med. 2004 Jun;45(6):491-9 [15164393] Environ Res. 2004 Nov;96(3):283-9 [15364595] Arch Environ Contam Toxicol. 1994 Jan;26(1):37-46 [8110022] J Occup Med. 1994 Nov;36(11):1240-6 [7861269] Environ Health Perspect. 1995 Dec;103(12):1126-34 [8747019] J Expo Anal Environ Epidemiol. 1997 Jan-Mar;7(1):61-80 [9076610] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] Am J Ind Med. 1998 Dec;34(6):581-7 [9816416] J Expo Anal Environ Epidemiol. 2004 Nov;14(6):473-8 [15026777] J Occup Environ Hyg. 2005 Jul;2(7):357-67 [16020099] J Expo Sci Environ Epidemiol. 2006 Jan;16(1):98-104 [16015277] Environ Health Perspect. 2006 Jun;114(6):893-7 [16759991] Environ Health Perspect. 2006 Jul;114(7):999-1006 [16835050] J Expo Sci Environ Epidemiol. 2006 Sep;16(5):447-56 [16570094] J Expo Sci Environ Epidemiol. 2006 Sep;16(5):387-96 [16249796] J Agromedicine. 2006;11(2):81-8 [17135145] Ann Occup Hyg. 2007 Jan;51(1):53-65 [16984946] Environ Health Perspect. 2007 Mar;115(3):370-6 [17431485] Environ Sci Technol. 2007 May 15;41(10):3408-14 [17547156] J Expo Sci Environ Epidemiol. 2007 Jul;17(4):388-99 [17033681] Hum Reprod Update. 2008 Jan-Feb;14(1):59-72 [18070835] Environ Health Perspect. 2008 May;116(5):687-94 [18470300] Radiat Prot Dosimetry. 2008;132(2):148-55 [18930927] Environ Sci Technol. 2009 Dec 1;43(23):8767-74 [19943644] Environ Health Perspect. 2010 Jun;118(6):856-63 [20129873] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408273 ER - TY - JOUR T1 - Bioreactor Process Parameter Screening Utilizing a Plackett-Burman Design for a Model Monoclonal Antibody AN - 1683350675; PQ0001587256 AB - Consistent high-quality antibody yield is a key goal for cell culture bioprocessing. This endpoint is typically achieved in commercial settings through product and process engineering of bioreactor parameters during development. When the process is complex and not optimized, small changes in composition and control may yield a finished product of less desirable quality. Therefore, changes proposed to currently validated processes usually require justification and are reported to the US FDA for approval. Recently, design-of-experiments-based approaches have been explored to rapidly and efficiently achieve this goal of optimized yield with a better understanding of product and process variables that affect a product's critical quality attributes. Here, we present a laboratory-scale model culture where we apply a Plackett-Burman screening design to parallel cultures to study the main effects of 11 process variables. This exercise allowed us to determine the relative importance of these variables and identify the most important factors to be further optimized in order to control both desirable and undesirable glycan profiles. We found engineering changes relating to culture temperature and nonessential amino acid supplementation significantly impacted glycan profiles associated with fucosylation, beta -galactosylation, and sialylation. All of these are important for monoclonal antibody product quality. J Pharm Sci 104:1919-1928, 2015 JF - Journal of Pharmaceutical Sciences AU - Agarabi, Cyrus D AU - Schiel, John E AU - Lute, Scott C AU - Chavez, Brittany K AU - Boyne, Michael T AU - Brorson, Kurt A AU - Khan, Mansoor A AU - Read, Erik K AD - Division of Product Quality Research, Office of Testing and Research, OPS, CDER, FDA, Silver Spring, Maryland. Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 1919 EP - 1928 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 6 SN - 0022-3549, 0022-3549 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Amino acids KW - Monoclonal antibodies KW - Bioreactors KW - Process engineering KW - Cell culture KW - Polysaccharides KW - Supplementation KW - Physical training KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683350675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Bioreactor+Process+Parameter+Screening+Utilizing+a+Plackett-Burman+Design+for+a+Model+Monoclonal+Antibody&rft.au=Agarabi%2C+Cyrus+D%3BSchiel%2C+John+E%3BLute%2C+Scott+C%3BChavez%2C+Brittany+K%3BBoyne%2C+Michael+T%3BBrorson%2C+Kurt+A%3BKhan%2C+Mansoor+A%3BRead%2C+Erik+K&rft.aulast=Agarabi&rft.aufirst=Cyrus&rft.date=2015-06-01&rft.volume=104&rft.issue=6&rft.spage=1919&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24420 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Temperature effects; Amino acids; Monoclonal antibodies; Process engineering; Bioreactors; Cell culture; Polysaccharides; Supplementation; Physical training DO - http://dx.doi.org/10.1002/jps.24420 ER - TY - JOUR T1 - The impact of extended closing times of alcohol outlets on alcohol-related injuries in the nightlife areas of Amsterdam: a controlled before-and-after evaluation AN - 1683081951; 4675739 AB - The municipality of Amsterdam implemented a new alcohol policy allowing alcohol outlets in two of the five nightlife areas to extend their closing times from 1 April 2009 onwards. We investigated how levels and trends of alcohol-related injuries changed after implementation of this alcohol policy, by comparing areas with extended closing times to those without. A controlled before-and-after evaluation to compare changes in alcohol-related injuries between intervention and control areas. Central district of Amsterdam, The Netherlands. Alcohol-related ambulance attendances for control and intervention areas between 1 April 2006 and 1 April 2009 (respectively, n=544 and n=499) and between 1 April 2009 and 1 April 2011 (respectively, n  ;=357 and n=480). Alcohol-related injuries were defined as ambulance attendances for people who suffered from direct or indirect consequences of alcohol consumption. Injuries were counted per month in two intervention and three control nightlife areas. We used Poisson regression to assess changes in injuries. After 1 April 2009, intervention areas showed a larger change in the level of alcohol-related injuries than control areas [incidence rate ratio 1.34, 95% confidence interval (CI)=1.12, 1.61], but trends remained stable in all areas. This increase was only statistically significant for the following subgroups: 2.00-5.59  ;a.m., weekend days, men, individuals aged 25-34 years, and people transported to a hospital. However, the increase did not differ between subgroups with statistical significance. A 1-hour extension of alcohol outlet closing times in some of Amsterdam's nightlife areas was associated with 34% more alcohol-related injuries. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Kunst, Anton E AU - Goeij, Moniek C.M. De AU - Veldhuizen, Eleonore M AU - Buster, Marcel C.A. AD - University of Amsterdam ; Public Health Service of Amsterdam Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 955 EP - 964 VL - 110 IS - 6 SN - 0965-2140, 0965-2140 KW - Economics KW - Alcohol KW - Injuries KW - Alcoholism KW - Regression analysis KW - Netherlands KW - Drugs KW - Hospitals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683081951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+impact+of+extended+closing+times+of+alcohol+outlets+on+alcohol-related+injuries+in+the+nightlife+areas+of+Amsterdam%3A+a+controlled+before-and-after+evaluation&rft.au=Kunst%2C+Anton+E%3BGoeij%2C+Moniek+C.M.+De%3BVeldhuizen%2C+Eleonore+M%3BBuster%2C+Marcel+C.A.&rft.aulast=Kunst&rft.aufirst=Anton&rft.date=2015-06-01&rft.volume=110&rft.issue=6&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12886 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-05-26 N1 - Last updated - 2015-05-26 N1 - SubjectsTermNotLitGenreText - 913 561 6220; 6555 6220; 909; 10739 12228 10919; 3755; 6013 6590; 275 462 129 DO - http://dx.doi.org/10.1111/add.12886 ER - TY - JOUR T1 - Hepatitis C virus treatment as prevention among injecting drug users: who should we cure first? AN - 1683081789; 4675741 AB - Treatment of injecting drug users (IDU) for hepatitis C virus (HCV) infection may prevent onward transmission. Treating individuals who often share injecting equipment is most likely to prevent new infections. However, these high-risk IDU are also more likely to become re-infected than low-risk IDU. We investigated to which group treatment is best targeted. We modelled the expected benefits per treatment of one chronically HCV‐ ;infected IDU in a population of low- and high-risk IDU. The benefits of treating one low- or one high-risk IDU were compared. Benefits included the probability for the treated IDU to become and remain uninfected, as well as the expected number of prevented infections to others (i.e. we quantified the total expected decrease in chronic infections). We found a threshold in HCV-RNA prevalence above which treating low-risk IDU, and below which treating high-risk IDU, resulted in the greatest benefits. This threshold was at 50% of exchanged syringes being HCV contaminated. When 42% of IDU engaged in high-risk behaviour (borrowing and lending out syringes 7.3 times more frequently than low-risk IDU), the corresponding threshold of HCV-RNA prevalence among IDU was at 32%. Larger-risk heterogeneity led to a lower corresponding threshold among IDU. A combination of HCV treatment and 50% risk reduction was best directed at high-risk IDU for prevalence among syringes up to 59%. The threshold was marginally sensitive to changes in disease and treatment variables. When more than half of all exchanged syringes in a population of injecting drug users (IDU) are contaminated by hepatitis C virus, it is most efficient to treat low-risk IDU first. Below this threshold, it is most efficient to treat high-risk IDU first. Reprinted by permission of Blackwell Publishing JF - Addiction AU - de Vos, Anneke S AU - Prins, Maria AU - Kretzschmar, Mirjam E.E. AD - University Medical Center Utrecht ; Public Health Service of Amsterdam ; University of Amsterdam Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 975 EP - 983 VL - 110 IS - 6 SN - 0965-2140, 0965-2140 KW - Sociology KW - Hepatitis KW - Prevention KW - Drug users KW - Medical treatment KW - Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683081789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Hepatitis+C+virus+treatment+as+prevention+among+injecting+drug+users%3A+who+should+we+cure+first%3F&rft.au=de+Vos%2C+Anneke+S%3BPrins%2C+Maria%3BKretzschmar%2C+Mirjam+E.E.&rft.aulast=de+Vos&rft.aufirst=Anneke&rft.date=2015-06-01&rft.volume=110&rft.issue=6&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12842 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-05-26 N1 - Last updated - 2015-05-26 N1 - SubjectsTermNotLitGenreText - 5810 3617 6220; 3754 3755; 7890 5792 10484; 10072; 3617 6220 DO - http://dx.doi.org/10.1111/add.12842 ER - TY - JOUR T1 - Elucidating the links between endocrine disruptors and neurodevelopment. AN - 1681912233; 25714811 AB - Recent data indicate that approximately 12% of children in the United States are affected by neurodevelopmental disorders, including attention deficit hyperactivity disorder, learning disorders, intellectual disabilities, and autism spectrum disorders. Accumulating evidence indicates a multifactorial etiology for these disorders, with social, physical, genetic susceptibility, nutritional factors, and chemical toxicants acting together to influence risk. Exposure to endocrine-disrupting chemicals during the early stages of life can disrupt normal patterns of development and thus alter brain function and disease susceptibility later in life. This article highlights research efforts and pinpoints approaches that could shed light on the possible associations between environmental chemicals that act on the endocrine system and compromised neurodevelopmental outcomes. JF - Endocrinology AU - Schug, Thaddeus T AU - Blawas, Ashley M AU - Gray, Kimberly AU - Heindel, Jerrold J AU - Lawler, Cindy P AD - Division of Extramural Research and Training (T.T.S., K.G., J.J.H., C.P.L.), National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709; and Duke University (A.M.B.), Durham, North Carolina 27708. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1941 EP - 1951 VL - 156 IS - 6 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Metals, Heavy KW - Pesticides KW - Phenols KW - DDT KW - CIW5S16655 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - bisphenol A KW - MLT3645I99 KW - Abridged Index Medicus KW - Index Medicus KW - Benzhydryl Compounds -- toxicity KW - Disease Susceptibility KW - Polychlorinated Biphenyls -- toxicity KW - Humans KW - DDT -- toxicity KW - Phenols -- toxicity KW - Endocrine System -- drug effects KW - Metals, Heavy -- toxicity KW - Pesticides -- toxicity KW - Endocrine Disruptors -- toxicity KW - Nervous System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1681912233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Elucidating+the+links+between+endocrine+disruptors+and+neurodevelopment.&rft.au=Schug%2C+Thaddeus+T%3BBlawas%2C+Ashley+M%3BGray%2C+Kimberly%3BHeindel%2C+Jerrold+J%3BLawler%2C+Cindy+P&rft.aulast=Schug&rft.aufirst=Thaddeus&rft.date=2015-06-01&rft.volume=156&rft.issue=6&rft.spage=1941&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2014-1734 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-19 N1 - Date created - 2015-05-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1210/en.2014-1734 ER - TY - JOUR T1 - Survival and susceptibility of Burkholderia cepacia complex in chlorhexidine gluconate and benzalkonium chloride. AN - 1680955997; 25794566 AB - The Burkholderia cepacia complex (BCC) includes opportunistic pathogenic bacteria that have occasionally been recovered from various pharmaceutical products, including antiseptics and disinfectants. Plausible reasons for the contamination include intrinsic sources, such as inadequate process controls, especially for water or equipment used during product manufacture, or extrinsic sources, such as improper handling and dilution or distribution in contaminated containers. Because the survival of BCC in antiseptics is a concern to the public health and pharmaceutical industry, we determined minimum inhibitory concentrations (MICs) of 36 BCC strains against the antiseptics, following exposure to chlorhexidine gluconate (CHX) and benzalkonium chloride (BZK) solutions (1-500 µg/ml for each chemical). Susceptibility to CHX and BZK varied across the BCC strains and was recorded as mean 90.3 and 111.1 µg/ml, respectively, at initial inoculation, which was significantly higher than the 46.4 and 61.1 µg/ml levels measured for BCC incubated in water for 40 days. After determining antiseptic MICs of individual BCC strains, BCC recovery was measured on Tryptic Soy Agar (TSA), Reasoner's Second Agar (R2A) and diluted preparations of these media under their sub-MICs. The survival of BCC was monitored for 14 days (336 h) in sub-MICs diluted to less than their antiseptic susceptible concentration value. Diluted TSA and R2A media exhibited greater efficiency of recovery for most BCC strains from the CHX and BZK solutions than full strength TSA or R2A. For BCC survival in antiseptic solutions, the cell number of BCC decreased rapidly within the first 20 min in both antiseptics, but after this, recovery remained constant in CHX and increased in BZK over the 14 day incubation period. The results indicate that BCC in water can remain viable with low susceptibility to antiseptics for 14 days, which suggests the necessity for improved detection methods and control measures to monitor BCC contamination in pharmaceutical products. JF - Journal of industrial microbiology & biotechnology AU - Kim, Jeong Myeong AU - Ahn, Youngbeom AU - LiPuma, John J AU - Hussong, David AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079-9502, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 905 EP - 913 VL - 42 IS - 6 KW - Anti-Infective Agents, Local KW - 0 KW - Benzalkonium Compounds KW - Disinfectants KW - chlorhexidine gluconate KW - MOR84MUD8E KW - Chlorhexidine KW - R4KO0DY52L KW - Index Medicus KW - Drug Contamination KW - Microbial Sensitivity Tests KW - Chlorhexidine -- analogs & derivatives KW - Benzalkonium Compounds -- pharmacology KW - Anti-Infective Agents, Local -- pharmacology KW - Chlorhexidine -- pharmacology KW - Microbial Viability -- drug effects KW - Burkholderia cepacia complex -- drug effects KW - Disinfectants -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680955997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+industrial+microbiology+%26+biotechnology&rft.atitle=Survival+and+susceptibility+of+Burkholderia+cepacia+complex+in+chlorhexidine+gluconate+and+benzalkonium+chloride.&rft.au=Kim%2C+Jeong+Myeong%3BAhn%2C+Youngbeom%3BLiPuma%2C+John+J%3BHussong%2C+David%3BCerniglia%2C+Carl+E&rft.aulast=Kim&rft.aufirst=Jeong&rft.date=2015-06-01&rft.volume=42&rft.issue=6&rft.spage=905&rft.isbn=&rft.btitle=&rft.title=Journal+of+industrial+microbiology+%26+biotechnology&rft.issn=1476-5535&rft_id=info:doi/10.1007%2Fs10295-015-1605-x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-21 N1 - Date created - 2015-05-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10295-015-1605-x ER - TY - JOUR T1 - Influence of yogurt fermentation and refrigerated storage on the stability of protein toxin contaminants. AN - 1680210223; 25772284 AB - Dairy products sold in a ready-to-eat form present the risk that adulterants persisting through manufacturing, storage, and distribution would reach consumers. Pathogenic microbes, including shigatoxigenic strains of Escherichia coli and the toxins they produce, are common food safety hazards associated with dairy products. Ricin and abrin are plant-derived ribosome-inactivating protein toxins related to the shiga-like toxins produced by E. coli. Limited information exists on the effects of manufacturing processes on the stabilities of these heat-resistant ribosome-inactivating proteins in the presence of foods. The goal of this study was to determine how typical yogurt manufacturing and storage processes influence ribosome-inactivating protein toxins. Ricin and abrin were added to skim or whole milk and batch pasteurized. Complete inactivation of both toxins was observed after 30 minutes at 85 °C. If the toxins were added after pasteurization, the levels of ricin and abrin in yogurt and their cytotoxic activities did not change significantly during fermentation or refrigerated storage for 4 weeks. The activities of ricin and abrin were inhibited by skim milk, nonfat yogurt, whole milk, and whole milk yogurt. The results showed minimal effects of the toxins on yogurt pH and %titratable acidity but inhibitory effects of yogurt on toxin activity. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Jackson, Lauren S AU - Triplett, Odbert A AU - Tolleson, William H AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, 6502 S. Archer Rd., Bedford Park, IL 60501, USA. ; Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR, USA. ; Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR, USA. Electronic address: william.tolleson@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 101 EP - 107 VL - 80 KW - Bacterial Toxins KW - 0 KW - Abrin KW - 1393-62-0 KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Yogurt KW - Dairy KW - Manufacture KW - Stability KW - Food Microbiology KW - Fermentation KW - Abrin -- chemistry KW - Food Handling KW - Pasteurization KW - Ricin -- chemistry KW - Refrigeration KW - Yogurt -- microbiology KW - Yogurt -- analysis KW - Food Storage KW - Food Contamination KW - Bacterial Toxins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680210223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Influence+of+yogurt+fermentation+and+refrigerated+storage+on+the+stability+of+protein+toxin+contaminants.&rft.au=Jackson%2C+Lauren+S%3BTriplett%2C+Odbert+A%3BTolleson%2C+William+H&rft.aulast=Jackson&rft.aufirst=Lauren&rft.date=2015-06-01&rft.volume=80&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-25 N1 - Date created - 2015-05-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.03.003 ER - TY - JOUR T1 - Investigation of melamine and cyanuric acid deposition in pig tissues using LC-MS/MS methods. AN - 1680209200; 25818466 AB - Four LC-MS/MS methods were developed to quantify melamine (MEL) and cyanuric acid (CYA) in various pig tissues at or above the level of concern (2.5 mg/kg). Pigs treated with 200 mg/kg bw/day CYA daily for 7 days did not accumulate significant residue concentrations in muscle, liver or kidney. Pigs treated with 200 mg/kg bw MEL daily for 7 or 28 days had MEL residues in muscles (3-13 ppm), liver (2.8-14.1 ppm) and kidney (9.4-27.2 ppm). Treatment with MEL and CYA at 100 mg/kg bw of each triazine daily for 7 days resulted in MEL (26-59 ppm in muscle, 30-49 ppm in liver and 367-6300 ppm in kidney) and CYA (1.8-5.8 ppm in muscle, 2.6-6.5 ppm in liver and 303-7100 ppm in kidney). Treatment with MEL and CYA at 1, 3 or 10 mg/kg bw/day for 7 days did not result in residues greater than the level of concern in all tissues tested. Pigs dosed with 33 mg/kg bw/day of MEL + CYA for 7 days contained residues above the level of concern only in kidney. Deposition of MEL and CYA depends on the tissue type (muscles, liver and kidney), dosage and whether the triazines are given alone or in combination. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Tkachenko, Andriy AU - Clark, James AU - Knutson, Natalie AU - Wallace, Betzy AU - Bomba, Malgorzata AU - Yacopucci, Michele AU - Rhodes, Blaine AU - Nemser, Sarah M AU - Guag, Jake AU - Reimschuessel, Renate AD - United States Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd., Laurel, MD 20708, USA. ; State Laboratory, Arizona Department of Health Services, 250 N. 17th Avenue, Phoenix, AZ 85007, USA. ; New Hampshire State Public Health Laboratory, 29 Hazen Drive, Concord, NH 03301, USA. ; Washington State Public Health Laboratory, 1610 N.E. 150th St., Shoreline, WA 98155, USA. ; United States Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd., Laurel, MD 20708, USA. Electronic address: renate.reimschuessel@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 310 EP - 318 VL - 80 KW - Triazines KW - 0 KW - cyanuric acid KW - H497R4QKTZ KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Residues KW - Melamine KW - Pig KW - Mass spectrometry KW - Cyanuric acid KW - Animals KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Chromatography, Liquid KW - Tandem Mass Spectrometry KW - Triazines -- metabolism KW - Kidney -- chemistry KW - Swine -- metabolism KW - Muscle, Skeletal -- chemistry KW - Liver -- chemistry KW - Triazines -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680209200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Investigation+of+melamine+and+cyanuric+acid+deposition+in+pig+tissues+using+LC-MS%2FMS+methods.&rft.au=Tkachenko%2C+Andriy%3BClark%2C+James%3BKnutson%2C+Natalie%3BWallace%2C+Betzy%3BBomba%2C+Malgorzata%3BYacopucci%2C+Michele%3BRhodes%2C+Blaine%3BNemser%2C+Sarah+M%3BGuag%2C+Jake%3BReimschuessel%2C+Renate&rft.aulast=Tkachenko&rft.aufirst=Andriy&rft.date=2015-06-01&rft.volume=80&rft.issue=&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-25 N1 - Date created - 2015-05-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.03.007 ER - TY - JOUR T1 - A retrospective analysis of allergic reaction severities and minimal eliciting doses for peanut, milk, egg, and soy oral food challenges. AN - 1680209146; 25748389 AB - Food allergy is a public health concern, affecting up to 6% of children and 2% of adults. The severity of allergic reactions can range from mild to potentially life-threatening. In addition, the minimum amount of protein needed to provoke an allergic reaction in an individual patient (the minimal eliciting dose (MED)) ranges from a few micrograms to several grams. To determine whether a retrospective analysis of published data from oral food challenges could be used to assess the potential relationship between MEDs and reaction severities at the MEDs, a three class (mild, moderate, severe) reaction grading system was developed by integrating previously published reaction grading systems. MEDs and symptoms were collected from food challenge studies and each reaction was graded using the integrated grading system. Peanut allergic patients who experienced severe reactions had significantly higher MEDs and threshold distribution doses than those who experienced mild and moderate reactions. No significant differences in threshold distributions according to the severity grading were found for milk, egg and soy. The relationship between threshold dose distribution and reaction severity based on these grading criteria differed between peanut and other allergens, and severe reactions were found to occur in some patients at low MEDs for all of these food allergens. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Zhu, Jianmei AU - Pouillot, Régis AU - Kwegyir-Afful, Ernest K AU - Luccioli, Stefano AU - Gendel, Steven M AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. ; Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. Electronic address: steven.gendel@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 92 EP - 100 VL - 80 KW - Allergens KW - 0 KW - Index Medicus KW - Food allergen KW - Oral food challenges KW - Reaction severity KW - Eliciting dose KW - Animals KW - Humans KW - Dose-Response Relationship, Immunologic KW - Retrospective Studies KW - Milk Hypersensitivity KW - Peanut Hypersensitivity KW - Soy Foods KW - Allergens -- administration & dosage KW - Egg Hypersensitivity KW - Food Hypersensitivity -- pathology KW - Food Hypersensitivity -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680209146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=A+retrospective+analysis+of+allergic+reaction+severities+and+minimal+eliciting+doses+for+peanut%2C+milk%2C+egg%2C+and+soy+oral+food+challenges.&rft.au=Zhu%2C+Jianmei%3BPouillot%2C+R%C3%A9gis%3BKwegyir-Afful%2C+Ernest+K%3BLuccioli%2C+Stefano%3BGendel%2C+Steven+M&rft.aulast=Zhu&rft.aufirst=Jianmei&rft.date=2015-06-01&rft.volume=80&rft.issue=&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.02.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-25 N1 - Date created - 2015-05-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.02.023 ER - TY - JOUR T1 - Different cytotoxicity responses to antimicrobial nanosilver coatings when comparing extract-based and direct-contact assays. AN - 1675877387; 25645305 AB - This study was performed to understand how the choice of cytotoxicity assay format affects the observed biocompatibility of nanosilver (nAg). nAg coatings are physical coatings containing silver (Ag) that have feature sizes of 100 nm or less, often in the form of nanoparticles or grains. They are used on medical devices to prevent infection, but in spite of this intended benefit, observations of potential cytotoxicity from nAg have been reported in numerous published studies. For medical device regulation, cytotoxicity testing is part of a biocompatibility evaluation, in which specific test methods are chosen based on the technological characteristics and intended use of a device. For this study, nAg-coated tissue culture polystyrene surfaces were prepared using magnetron sputter coating, resulting in nAg films of 0.2 to 311 µg cm(-2) Ag. These coatings exhibited nanometer-scale morphologies and demonstrated a > 4log10 reduction in Escherichia coli viability. It was observed that extracts of nAg caused no cytotoxicity to L929 mouse fibroblasts, but cells cultured directly on nAg coatings (direct-contact assay format) showed a dose-dependent reduction in viability by up to 100% (P < 0.001). Results using inductively coupled plasma mass spectrometry to measure Ag release suggested that extracts of nAg are not toxic because the dissolved Ag in those samples becomes less cytotoxic over time, probably owing to the reaction with cell culture media and serum (six-fold cytotoxicity reductions observed over a 24-h period). These findings highlight the potential value of direct-contact cytotoxicity testing for nAg in predicting biological interactions with cells or tissue in vivo. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied toxicology : JAT AU - Sussman, Eric M AU - Casey, Brendan J AU - Dutta, Debargh AU - Dair, Benita J AD - Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 631 EP - 639 VL - 35 IS - 6 KW - Anti-Infective Agents KW - 0 KW - Coated Materials, Biocompatible KW - Silver Compounds KW - Index Medicus KW - medical device coating KW - nanosilver KW - direct-contact KW - cytotoxicity KW - antibacterial KW - extract KW - biocompatibility KW - Animals KW - Cell Survival -- drug effects KW - Escherichia coli -- drug effects KW - Coated Materials, Biocompatible -- adverse effects KW - Toxicity Tests -- methods KW - Mice KW - Coated Materials, Biocompatible -- administration & dosage KW - Cell Line KW - Metal Nanoparticles -- administration & dosage KW - Fibroblasts -- drug effects KW - Anti-Infective Agents -- adverse effects KW - Silver Compounds -- administration & dosage KW - Metal Nanoparticles -- adverse effects KW - Anti-Infective Agents -- administration & dosage KW - Silver Compounds -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675877387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Different+cytotoxicity+responses+to+antimicrobial+nanosilver+coatings+when+comparing+extract-based+and+direct-contact+assays.&rft.au=Sussman%2C+Eric+M%3BCasey%2C+Brendan+J%3BDutta%2C+Debargh%3BDair%2C+Benita+J&rft.aulast=Sussman&rft.aufirst=Eric&rft.date=2015-06-01&rft.volume=35&rft.issue=6&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3104 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-11 N1 - Date created - 2015-04-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3104 ER - TY - JOUR T1 - Genomics in the land of regulatory science. AN - 1675876549; 25796433 AB - Genomics science has played a major role in the generation of new knowledge in the basic research arena, and currently question arises as to its potential to support regulatory processes. However, the integration of genomics in the regulatory decision-making process requires rigorous assessment and would benefit from consensus amongst international partners and research communities. To that end, the Global Coalition for Regulatory Science Research (GCRSR) hosted the fourth Global Summit on Regulatory Science (GSRS2014) to discuss the role of genomics in regulatory decision making, with a specific emphasis on applications in food safety and medical product development. Challenges and issues were discussed in the context of developing an international consensus for objective criteria in the analysis, interpretation and reporting of genomics data with an emphasis on transparency, traceability and "fitness for purpose" for the intended application. It was recognized that there is a need for a global path in the establishment of a regulatory bioinformatics framework for the development of transparent, reliable, reproducible and auditable processes in the management of food and medical product safety risks. It was also recognized that training is an important mechanism in achieving internationally consistent outcomes. GSRS2014 provided an effective venue for regulators andresearchers to meet, discuss common issues, and develop collaborations to address the challenges posed by the application of genomics to regulatory science, with the ultimate goal of wisely integrating novel technical innovations into regulatory decision-making. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Tong, Weida AU - Ostroff, Stephen AU - Blais, Burton AU - Silva, Primal AU - Dubuc, Martine AU - Healy, Marion AU - Slikker, William AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. Electronic address: Weida.tong@fda.hhs.gov. ; Office of the Chief Scientist, US Food and Drug Administration, Silver Spring, MD, USA. ; Canadian Food Inspection Agency, Ottawa, Ontario, Canada. ; Foods Standards Australia New Zealand, Canberra, ACT, Australia. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. Electronic address: William.slikker@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 102 EP - 106 VL - 72 IS - 1 KW - Index Medicus KW - Regulatory science KW - Next generation sequencing KW - Genomics KW - Humans KW - Computational Biology -- methods KW - Food Safety -- methods KW - Decision Making KW - Genomics -- methods KW - Science -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675876549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Genomics+in+the+land+of+regulatory+science.&rft.au=Tong%2C+Weida%3BOstroff%2C+Stephen%3BBlais%2C+Burton%3BSilva%2C+Primal%3BDubuc%2C+Martine%3BHealy%2C+Marion%3BSlikker%2C+William&rft.aulast=Tong&rft.aufirst=Weida&rft.date=2015-06-01&rft.volume=72&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-13 N1 - Date created - 2015-04-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.03.008 ER - TY - JOUR T1 - Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness. AN - 1675169335; 25753028 AB - Gulf War Illness (GWI) is a multi-symptom disorder with features characteristic of persistent sickness behavior. Among conditions encountered in the Gulf War (GW) theater were physiological stressors (e.g., heat/cold/physical activity/sleep deprivation), prophylactic treatment with the reversible AChE inhibitor, pyridostigmine bromide (PB), the insect repellent, N,N-diethyl-meta-toluamide (DEET), and potentially the nerve agent, sarin. Prior exposure to the anti-inflammatory glucocorticoid, corticosterone (CORT), at levels associated with high physiological stress, can paradoxically prime the CNS to produce a robust proinflammatory response to neurotoxicants and systemic inflammation; such neuroinflammatory effects can be associated with sickness behavior. Here, we examined whether CORT primed the CNS to mount neuroinflammatory responses to GW exposures as a potential model of GWI. Male C57BL/6 mice were treated with chronic (14 days) PB/ DEET, subchronic (7-14 days) CORT, and acute exposure (day 15) to diisopropyl fluorophosphate (DFP), a sarin surrogate and irreversible AChE inhibitor. DFP alone caused marked brain-wide neuroinflammation assessed by qPCR of tumor necrosis factor-α, IL6, chemokine (C-C motif) ligand 2, IL-1β, leukemia inhibitory factor, and oncostatin M. Pre-treatment with high physiological levels of CORT greatly augmented (up to 300-fold) the neuroinflammatory responses to DFP. Anti-inflammatory pre-treatment with minocycline suppressed many proinflammatory responses to CORT+DFP. Our findings are suggestive of a possible critical, yet unrecognized interaction between the stressor/environment of the GW theater and agent exposure(s) unique to this war. Such exposures may in fact prime the CNS to amplify future neuroinflammatory responses to pathogens, injury, or toxicity. Such occurrences could potentially result in the prolonged episodes of sickness behavior observed in GWI. Gulf War (GW) veterans were exposed to stressors, prophylactic medicines and, potentially, nerve agents in theater. Subsequent development of GW Illness, a persistent multi-symptom disorder with features characteristic of sickness behavior, may be caused by priming of the CNS resulting in exaggerated neuroinflammatory responses to pathogens/insults. Nerve agent, diisopropyl fluorophosphate (DFP), produced a neuroinflammatory response that was exacerbated by pre-treatment with levels of corticosterone simulating heightened stressor conditions. While prophylactic treatments reduced DFP-induced neuroinflammation, this effect was negated when those treatments were combined with corticosterone. © 2015 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of The International Society for Neurochemistry. JF - Journal of neurochemistry AU - O'Callaghan, James P AU - Kelly, Kimberly A AU - Locker, Alicia R AU - Miller, Diane B AU - Lasley, Steve M AD - Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 708 EP - 721 VL - 133 IS - 5 KW - Anti-Inflammatory Agents KW - 0 KW - Chemical Warfare Agents KW - Cholinesterase Inhibitors KW - Insect Repellents KW - Isoflurophate KW - 12UHW9R67N KW - DEET KW - 134-62-3 KW - Minocycline KW - FYY3R43WGO KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - microglia KW - GWI KW - minocycline KW - CORT KW - neuroinflammation KW - DFP KW - Animals KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Insect Repellents -- toxicity KW - Minocycline -- therapeutic use KW - DEET -- toxicity KW - Male KW - Persian Gulf Syndrome -- pathology KW - Cholinesterase Inhibitors -- toxicity KW - Anti-Inflammatory Agents -- therapeutic use KW - Isoflurophate -- antagonists & inhibitors KW - Corticosterone -- antagonists & inhibitors KW - Encephalitis -- chemically induced KW - Corticosterone -- pharmacology KW - Chemical Warfare Agents -- toxicity KW - Isoflurophate -- toxicity KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675169335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Corticosterone+primes+the+neuroinflammatory+response+to+DFP+in+mice%3A+potential+animal+model+of+Gulf+War+Illness.&rft.au=O%27Callaghan%2C+James+P%3BKelly%2C+Kimberly+A%3BLocker%2C+Alicia+R%3BMiller%2C+Diane+B%3BLasley%2C+Steve+M&rft.aulast=O%27Callaghan&rft.aufirst=James&rft.date=2015-06-01&rft.volume=133&rft.issue=5&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fjnc.13088 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-24 N1 - Date created - 2015-04-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neurotoxicol Teratol. 2012 Jan-Feb;34(1):72-82 [22108043] FASEB J. 2005 Aug;19(10):1329-31 [15919760] Am J Epidemiol. 2000 Nov 15;152(10):992-1002 [11092441] Psychiatry Res. 2001 Jun 1;102(2):175-200 [11408056] Methods. 2001 Dec;25(4):402-8 [11846609] Psychol Rep. 2002 Jun;90(3 Pt 1):707-21 [12090498] Neuroscience. 2002;115(1):307-20 [12401343] Brain Behav Immun. 2003 Feb;17 Suppl 1:S112-8 [12615196] Nat Genet. 2003 Apr;33(4):437-8 [12640456] Mol Med. 2003 May-Aug;9(5-8):125-34 [14571320] Brain Res. 2004 Oct 22;1024(1-2):59-76 [15451367] Anal Biochem. 1985 Oct;150(1):76-85 [3843705] J Neurosci. 1987 Apr;7(4):931-42 [3106588] Neuroscience. 1988 Jul;26(1):337-61 [2458546] J Neurochem. 1991 Sep;57(3):860-9 [1677678] Neurotoxicol Teratol. 1991 May-Jun;13(3):275-81 [1886537] Neurochem Int. 1996 Jul;29(1):25-35 [8808786] Nat Med. 1996 Dec;2(12):1382-5 [8946841] Nature. 1998 May 28;393(6683):308-9 [9620793] JAMA. 1998 Sep 16;280(11):981-8 [9749480] Neuromolecular Med. 2012 Dec;14(4):349-61 [22798222] Brain Behav Immun. 2013 Feb;28:159-69 [23201588] Transl Res. 2013 Feb;161(2):99-109 [23108365] PLoS One. 2013;8(3):e60388 [23555964] Mediators Inflamm. 2013;2013:271359 [23935246] Neuropsychopharmacology. 2013 Nov;38(12):2348-62 [23807240] Psychoneuroendocrinology. 2014 Feb;40:191-200 [24485491] Metabolism. 2005 May;54(5 Suppl 1):33-8 [15877311] Environ Health. 2015;14:4 [25575675] Prog Neurobiol. 2005 Jun;76(2):77-98 [16081203] J Neurochem. 2006 Jan;96(2):314-23 [16336636] J Neurochem. 2006 Feb;96(3):706-18 [16405514] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] Brain Behav Immun. 2007 Feb;21(2):153-60 [17088043] Brain Behav Immun. 2007 May;21(4):490-502 [17321719] J Neuroimmune Pharmacol. 2007 Jun;2(2):140-53 [18040839] Nat Rev Neurosci. 2008 Jan;9(1):46-56 [18073775] Neuro Endocrinol Lett. 2007 Dec;28(6):739-44 [18063928] Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4295-300 [18332428] Neuroscience. 2008 Mar 18;152(2):477-86 [18262365] J Neuroinflammation. 2008;5:15 [18477398] Nat Protoc. 2008;3(6):1101-8 [18546601] Neurosci Lett. 2008 Jul 25;440(1):63-7 [18541374] Neurobiol Aging. 2008 Nov;29(11):1744-53 [17543422] Ann N Y Acad Sci. 2008 Oct;1139:318-30 [18991877] Curr Opin Psychiatry. 2009 Jan;22(1):75-83 [19127706] Behav Brain Res. 2009 Feb 11;197(2):301-10 [18793677] Behav Brain Res. 2009 Feb 11;197(2):292-300 [18796314] J Infect Dis. 2009 May 1;199(9):1379-88 [19301981] Behav Brain Res. 2009 Nov 5;203(2):207-14 [19433115] J Pain. 2010 Aug;11(8):764-72 [20338824] Neurotoxicology. 2010 Dec;31(6):738-46 [20600289] Neurosci Biobehav Rev. 2011 Jan;35(3):742-64 [20883718] Brain Behav Immun. 2011 Oct;25(7):1408-15 [21536123] J Neuroinflammation. 2011;8:84 [21777430] J Neuroimmunol. 2011 Oct 28;239(1-2):53-60 [21907418] Neuromolecular Med. 2011 Dec;13(4):275-88 [21986894] Environ Health Perspect. 2012 Jan;120(1):112-8 [21930452] Neuropathology. 2014 Apr;34(2):109-27 [24118348] PLoS One. 2014;9(7):e102003 [25025494] J Neurochem. 2012 Sep;122(5):995-1009 [22776046] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/jnc.13088 ER - TY - JOUR T1 - Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability. AN - 1671213878; 25746383 AB - Impact on health by nanomaterials has become a public concern with the great advances of nanomaterials for various applications. Surface coating agents are an integral part of nanoparticles, but not enough attention has been paid during toxicity tests of nanoparticles. As a result, there are inconsistent toxicity results for certain nanomaterials. In this study, we explored the cytotoxicity of eleven commonly used surface coating agents in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h and 24 h, were employed for the study. Six of the eleven surface coating agents are cytotoxic, especially those surfactants with long aliphatic chains, both cationic (cetyltrimethylammonium bromide, oleylamine, tetraoctylammonium bromide, and hexadecylamine) and anionic (sodium dodecylsulfate). In addition, exposure time and the use of different cell lines also affect the cytotoxicity results. Therefore, factors such as cell lines used and exposure times must be considered when conducting toxicity tests or comparing cytotoxicity results. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Zhang, Ying AU - Newton, Brandon AU - Lewis, Eybriunna AU - Fu, Peter P AU - Kafoury, Ramzi AU - Ray, Paresh C AU - Yu, Hongtao AD - Departments of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39127, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Departments of Biology, Jackson State University, Jackson, MS 39127, USA. ; Departments of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39127, USA. Electronic address: yu@jsums.edu. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 762 EP - 768 VL - 29 IS - 4 KW - Amines KW - 0 KW - Organic Chemicals KW - Index Medicus KW - Surface coating agents KW - Cytotoxicity KW - Nanoparticle KW - SDS KW - Aliphatic amines KW - Cell Survival -- drug effects KW - Organic Chemicals -- toxicity KW - Humans KW - Amines -- toxicity KW - Toxicity Tests KW - Amines -- chemistry KW - Cell Line, Tumor KW - Nanostructures -- chemistry KW - Nanoparticles -- toxicity KW - Nanostructures -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671213878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Cytotoxicity+of+organic+surface+coating+agents+used+for+nanoparticles+synthesis+and+stability.&rft.au=Zhang%2C+Ying%3BNewton%2C+Brandon%3BLewis%2C+Eybriunna%3BFu%2C+Peter+P%3BKafoury%2C+Ramzi%3BRay%2C+Paresh+C%3BYu%2C+Hongtao&rft.aulast=Zhang&rft.aufirst=Ying&rft.date=2015-06-01&rft.volume=29&rft.issue=4&rft.spage=762&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2015.01.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-21 N1 - Date created - 2015-04-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Sci Technol. 2013 Sep 17;47(18):10293-301 [23952964] Langmuir. 2013 Apr 16;29(15):4647-51 [23544954] Toxicol Ind Health. 2014 Jul;30(6):489-98 [23012341] Am J Respir Crit Care Med. 1999 Dec;160(6):1934-42 [10588609] Nat Biotechnol. 2003 Oct;21(10):1166-70 [14520401] Arch Toxicol. 1974;32(4):245-70 [4614759] Toxicol Appl Pharmacol. 1998 Jun;150(2):338-49 [9653065] Biomaterials. 2005 Oct;26(29):5818-26 [15949547] Toxicol Lett. 2005 Aug 14;158(2):122-32 [16039401] Small. 2005 Mar;1(3):325-7 [17193451] Small. 2006 Jun;2(6):766-73 [17193121] Small. 2009 Mar;5(6):701-8 [19226599] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Jan;27(1):1-35 [19204862] Environ Toxicol. 2007 Apr;22(2):159-68 [17366569] Environ Sci Technol. 2010 Jul 1;44(13):5210-5 [20509652] Sci Total Environ. 2010 Sep 15;408(20):4475-81 [20673962] Chem Rev. 2010 Sep 8;110(9):5332-65 [20469927] Environ Sci Technol. 2011 Jun 15;45(12):5260-6 [21598969] Environ Sci Technol. 2012 Jan 17;46(2):1119-27 [22148238] Toxicol In Vitro. 2013 Feb;27(1):330-8 [22940466] J Food Drug Anal. 2014 Mar;22(1):116-27 [24673909] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2015.01.017 ER - TY - CPAPER T1 - Traceability and Food Safety Systems T2 - 115th General Meeting of the American Society for Microbiology (ASM 2015) AN - 1658698535; 6336180 JF - 115th General Meeting of the American Society for Microbiology (ASM 2015) AU - Elliott, Elisa Y1 - 2015/05/30/ PY - 2015 DA - 2015 May 30 KW - Food KW - Food contamination KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658698535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2015%29&rft.atitle=Traceability+and+Food+Safety+Systems&rft.au=Elliott%2C+Elisa&rft.aulast=Elliott&rft.aufirst=Elisa&rft.date=2015-05-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={224BAD71-94EA-4FA5-8DF3-F4087BDC3625} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - JOUR T1 - Incubation of Methamphetamine Craving Is Associated with Selective Increases in Expression of Bdnf and Trkb, Glutamate Receptors, and Epigenetic Enzymes in Cue-Activated Fos-Expressing Dorsal Striatal Neurons AN - 1735914723; PQ0002270521 AB - Cue-induced methamphetamine seeking progressively increases after withdrawal (incubation of methamphetamine craving), but the underlying mechanisms are largely unknown. We determined whether this incubation is associated with alterations in candidate genes in dorsal striatum (DS), a brain area implicated in cue- and context-induced drug relapse. We first measured mRNA expression of 24 candidate genes in whole DS extracts after short (2 d) or prolonged (1 month) withdrawal in rats following extended-access methamphetamine or saline (control condition) self-administration (9 h/d, 10 d). We found minimal changes. Next, using fluorescence-activated cell sorting, we compared gene expression in Fos-positive dorsal striatal neurons, which were activated during "incubated" cue-induced drug-seeking tests after prolonged withdrawal, with nonactivated Fos-negative neurons. We found significant increases in mRNA expression of immediate early genes (Arc, Egr1), Bdnf and its receptor (rkb), glutamate receptor subunits (Gria1, Gria3, Grm1), and epigenetic enzymes (Hdac3, Hdac4, Hdac5, GLP, Dnmt3a, Kdm1a) in the Fos-positive neurons only. Using RNAscope to determine striatal subregion and cell-type specificity of the activated neurons, we measured colabeling of Fos with Drd1 and Drd2 in three DS subregions. Fos expression was neither subregion nor cell-type specific (52.5 and 39.2% of Fos expression colabeled with Drd1 and Drd2, respectively). Finally, we found that DS injections of SCH23390 (C sub(17)H sub(18)CINO), a D sub(1)-family receptor antagonist known to block cue-induced Fos induction, decreased incubated cue-induced methamphetamine seeking after prolonged withdrawal. Results demonstrate a critical role of DS in incubation of methamphetamine craving and that this incubation is associated with selective gene-expression alterations in cue-activated D sub(1)- and D sub(2)-expressing DS neurons. JF - Journal of Neuroscience AU - Li, Xuan AU - Rubio, F Javier AU - Zeric, Tamara AU - Bossert, Jennifer M AU - Kambhampati, Sarita AU - Cates, Hannah M AU - Kennedy, Pamela J AU - Liu, Qing-Rong AU - Cimbro, Raffaello AU - Hope, Bruce T AU - Nestler, Eric J AU - Shaham, Yavin AD - Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services, Baltimore, Maryland 21224 Y1 - 2015/05/27/ PY - 2015 DA - 2015 May 27 SP - 8232 EP - 8244 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Washington DC 20036 United States VL - 35 IS - 21 SN - 0270-6474, 0270-6474 KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - dorsal striatum KW - epigenetics KW - FACS KW - glutamate KW - methamphetamine KW - relapse KW - Dopamine D2 receptors KW - Brain-derived neurotrophic factor KW - Dopamine D1 receptors KW - Enzymes KW - Drug development KW - Drug abuse KW - Glutamic acid receptors KW - Fos protein KW - Flow cytometry KW - Gene expression KW - TrkB receptors KW - Methamphetamine KW - Nervous system KW - Neurons KW - Neostriatum KW - Self-administration KW - Immediate-early proteins KW - Drug addiction KW - EGR-1 protein KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25050:Genetics and Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735914723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Incubation+of+Methamphetamine+Craving+Is+Associated+with+Selective+Increases+in+Expression+of+Bdnf+and+Trkb%2C+Glutamate+Receptors%2C+and+Epigenetic+Enzymes+in+Cue-Activated+Fos-Expressing+Dorsal+Striatal+Neurons&rft.au=Li%2C+Xuan%3BRubio%2C+F+Javier%3BZeric%2C+Tamara%3BBossert%2C+Jennifer+M%3BKambhampati%2C+Sarita%3BCates%2C+Hannah+M%3BKennedy%2C+Pamela+J%3BLiu%2C+Qing-Rong%3BCimbro%2C+Raffaello%3BHope%2C+Bruce+T%3BNestler%2C+Eric+J%3BShaham%2C+Yavin&rft.aulast=Li&rft.aufirst=Xuan&rft.date=2015-05-27&rft.volume=35&rft.issue=21&rft.spage=8232&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/10.1523%2FJNEUROSCI.102215.2015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Brain-derived neurotrophic factor; Dopamine D2 receptors; Dopamine D1 receptors; Enzymes; Drug development; Drug abuse; Glutamic acid receptors; Fos protein; Gene expression; Flow cytometry; TrkB receptors; Nervous system; Methamphetamine; epigenetics; Neurons; Neostriatum; Self-administration; Immediate-early proteins; Drug addiction; EGR-1 protein DO - http://dx.doi.org/10.1523/JNEUROSCI.102215.2015 ER - TY - GEN T1 - Family and Provider/Teacher Relationship Quality: Director Measure AN - 1773221727; ED558536 AB - The director measure is intended for use with program directors in center-based, family child care, and Head Start/Early Head Start settings for children from birth through five years old. This measure asks respondents general questions about the early childhood education environment, the children enrolled in the program, and how the program supports family and provider/teacher relationships. It includes 57 items and takes about 10 minutes to complete, on average. The Excel scoring sheet for the director measure (revised April 2015) can be used to automatically calculate scores for the environment and policy checklist in the director measure. It is available in English only. Y1 - 2015/05/19/ PY - 2015 DA - 2015 May 19 SP - 6 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Administrators KW - Early Childhood Education KW - Preschool Education KW - Preschool Teachers KW - Measures (Individuals) KW - Educational Environment KW - Family School Relationship KW - Enrollment KW - Preschool Children KW - Interpersonal Relationship UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221727?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Spontaneous pharyngeal Chlamydia trachomatis RNA clearance. A cross-sectional study followed by a cohort study of untreated STI clinic patients in Amsterdam, The Netherlands AN - 1819139753; PQ0003430239 AB - ObjectivesPharyngeal Chlamydia trachomatis (chlamydia) might contribute to ongoing chlamydia transmission, yet data on spontaneous clearance duration are rare. We examined the prevalence, spontaneous clearance, chlamydial DNA concentration and genotypes of pharyngeal chlamydia among clinic patients with sexually transmitted infection (STI).MethodsFemale patients at high risk for an STI who reported active oral sex and male patients who have sex with men (MSM) were screened for pharyngeal chlamydia RNA using a nucleic acid amplification test. A repeat swab was obtained to evaluate spontaneous clearance in untreated patients with pharyngeal chlamydia. Quantitative chlamydia DNA load was determined by calculating the chlamydia/human cell ratio.ResultsPharyngeal chlamydia was detected in 148/13111 (1.1%) MSM and in 160/6915 (2.3%) women. 53% of MSM and 32% of women with pharyngeal chlamydia did not have a concurrent anogenital chlamydia infection. In 16/43 (37%) MSM and in 20/55 (36%) women, the repeat pharyngeal swab was negative (median follow-up 10days, range 4-58days). Patients with an initial chlamydial DNA concentration above the median were less likely to clear. Of 23 MSM with pharyngeal chlamydia who had sex with a lymphogranuloma venereum (LGV)-positive partner recently or in the past, two were LGV biovar positive (8.7%).ConclusionsThe pharynx is a reservoir for chlamydia and LGV, and may play a role in ongoing transmission. Although delay in ribosomal RNA decline after resolution of the infection might have led to an underestimation of spontaneous clearance, in high-risk STI clinic patients, testing the pharynx for chlamydia should be considered. JF - Sexually Transmitted Infections AU - van Rooijen, Martijn S AU - van der Loeff, Maarten F Schim AU - Morre, Servaas A AU - van Dam, Alje P AU - Speksnijder, Arjen G C L AU - de Vries, Henry J C AD - Public Health Laboratory, Public Health Service of Amsterdam (GGD Amsterdam), , Amsterdam, The Netherlands Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 SP - 157 EP - 164 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 91 IS - 3 SN - 1368-4973, 1368-4973 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - CHLAMYDIA TRACHOMATIS KW - ORAL CAVITY KW - ORAL SEX KW - SCREENING KW - TESTING KW - Pharynx KW - Data processing KW - Anogenital KW - Lymphogranuloma venereum KW - Chlamydia trachomatis KW - Genotypes KW - Infection KW - rRNA KW - nucleic acids KW - Risk factors KW - Risk groups KW - Sex KW - J 02400:Human Diseases KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819139753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=Spontaneous+pharyngeal+Chlamydia+trachomatis+RNA+clearance.+A+cross-sectional+study+followed+by+a+cohort+study+of+untreated+STI+clinic+patients+in+Amsterdam%2C+The+Netherlands&rft.au=van+Rooijen%2C+Martijn+S%3Bvan+der+Loeff%2C+Maarten+F+Schim%3BMorre%2C+Servaas+A%3Bvan+Dam%2C+Alje+P%3BSpeksnijder%2C+Arjen+G+C+L%3Bde+Vries%2C+Henry+J+C&rft.aulast=van+Rooijen&rft.aufirst=Martijn&rft.date=2015-05-18&rft.volume=91&rft.issue=3&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/10.1136%2Fsextrans-2014-051633 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - rRNA; nucleic acids; Data processing; Pharynx; Anogenital; Risk factors; Lymphogranuloma venereum; Risk groups; Genotypes; Infection; Sex; Chlamydia trachomatis DO - http://dx.doi.org/10.1136/sextrans-2014-051633 ER - TY - JOUR T1 - Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. AN - 1681916566; 25811541 AB - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious cutaneous adverse reactions. We mined the approved labels in Drugs@FDA, identified the SJS/TEN list of 259 small molecular drugs and biologics, and conducted systems pharmacological network analyses. Pharmacological network analysis revealed that drugs with treatment-related SJS and/or TEN are pharmacologically diverse and that the largest subnetwork is associated with antiepileptic drugs and their pharmacological targets. Our pharmacological network analysis identified CTNNB1 [catenin (cadherin-associated protein), beta 1, 88 kDa] as a significant intermediator. This protein is involved in maintaining the functional integrity of the epithelium through regulating cell growth and adhesion between cells in various organs, including the skin. Leveraging a publicly accessible genome-wide transcriptional expression database, we found that human leukocyte antigen-related (HLA) genes were significantly perturbed by various SJS/TEN-inducing drugs. Notably, carbamazepine (CBZ) perturbed several HLA genes, among which HLA-DQB1*0201 was reportedly shown to be associated with CBZ-induced SJS/TEN in caucasians. In short, systems analysis by leveraging a publicly accessible knowledge base and databases could produce meaningful results for further mechanistic investigation. Our study sheds light on the utility of systems pharmacology analysis for gaining insight into clinical drug toxicity. JF - Chemical research in toxicology AU - Hur, Junguk AU - Zhao, ChunSheng AU - Bai, Jane P F AD - ‡Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, United States. ; §Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, United States. Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 SP - 927 EP - 934 VL - 28 IS - 5 KW - Anticonvulsants KW - 0 KW - CTNNB1 protein, human KW - HLA-DQ beta-Chains KW - HLA-DQB1 antigen KW - Small Molecule Libraries KW - beta Catenin KW - Carbamazepine KW - 33CM23913M KW - Index Medicus KW - Carbamazepine -- adverse effects KW - Databases, Pharmaceutical KW - Risk Factors KW - Humans KW - beta Catenin -- metabolism KW - Gene Expression Regulation -- drug effects KW - HLA-DQ beta-Chains -- genetics KW - Small Molecule Libraries -- adverse effects KW - Anticonvulsants -- adverse effects KW - Stevens-Johnson Syndrome -- etiology KW - Stevens-Johnson Syndrome -- genetics KW - Stevens-Johnson Syndrome -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1681916566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Systems+pharmacological+analysis+of+drugs+inducing+stevens-johnson+syndrome+and+toxic+epidermal+necrolysis.&rft.au=Hur%2C+Junguk%3BZhao%2C+ChunSheng%3BBai%2C+Jane+P+F&rft.aulast=Hur&rft.aufirst=Junguk&rft.date=2015-05-18&rft.volume=28&rft.issue=5&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx5005248 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-10 N1 - Date created - 2015-05-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/tx5005248 ER - TY - CPAPER T1 - Use of Smartphone Sound Measurement Apps for Occupational Noise Assessments T2 - 169th Meeting of the Acoustical Society of America AN - 1669823919; 6341645 JF - 169th Meeting of the Acoustical Society of America AU - Kardous, Chucri AU - Celestina, Metod Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Sound measurement KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Use+of+Smartphone+Sound+Measurement+Apps+for+Occupational+Noise+Assessments&rft.au=Kardous%2C+Chucri%3BCelestina%2C+Metod&rft.aulast=Kardous&rft.aufirst=Chucri&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Comparison of Headphones for Audiometric Screening and Hearing Protector Fit-Testing T2 - 169th Meeting of the Acoustical Society of America AN - 1669823090; 6341647 JF - 169th Meeting of the Acoustical Society of America AU - Byrne, David AU - Schmitt, Laura AU - Murph, William Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Screening KW - Hearing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Comparison+of+Headphones+for+Audiometric+Screening+and+Hearing+Protector+Fit-Testing&rft.au=Byrne%2C+David%3BSchmitt%2C+Laura%3BMurph%2C+William&rft.aulast=Byrne&rft.aufirst=David&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Relationships among Ultrasonic and Mechanical Properties of Cancellous Bone T2 - 169th Meeting of the Acoustical Society of America AN - 1669822902; 6341627 JF - 169th Meeting of the Acoustical Society of America AU - Wear, Keith AU - Sadoughi, Saghi AU - Nagaraja, Srinidhi AU - Dreher, Maureen AU - Keaveny, Tony Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Bone (cancellous) KW - Ultrasound KW - Mechanical properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Relationships+among+Ultrasonic+and+Mechanical+Properties+of+Cancellous+Bone&rft.au=Wear%2C+Keith%3BSadoughi%2C+Saghi%3BNagaraja%2C+Srinidhi%3BDreher%2C+Maureen%3BKeaveny%2C+Tony&rft.aulast=Wear&rft.aufirst=Keith&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - A Simple Animal Model for Cerebral Vasculature Rupture Due to Exposure to Intense Pressure Waves T2 - 169th Meeting of the Acoustical Society of America AN - 1669822539; 6341942 JF - 169th Meeting of the Acoustical Society of America AU - Nabili, Marjan AU - Acharya, Priyanka AU - Kim, Yeon AU - Myers, Matthew Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Wave forces KW - Animal models KW - Rupture KW - Waves KW - Pressure KW - Elastic waves UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=A+Simple+Animal+Model+for+Cerebral+Vasculature+Rupture+Due+to+Exposure+to+Intense+Pressure+Waves&rft.au=Nabili%2C+Marjan%3BAcharya%2C+Priyanka%3BKim%2C+Yeon%3BMyers%2C+Matthew&rft.aulast=Nabili&rft.aufirst=Marjan&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Field Evaluations of a Noise Control for Roof Bolting Machines T2 - 169th Meeting of the Acoustical Society of America AN - 1669822531; 6341891 JF - 169th Meeting of the Acoustical Society of America AU - Azman, Amanda Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Noise levels KW - Bolting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Field+Evaluations+of+a+Noise+Control+for+Roof+Bolting+Machines&rft.au=Azman%2C+Amanda&rft.aulast=Azman&rft.aufirst=Amanda&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Acoustic requirements for audiometric testing and hearing protector fit-testing with mobile platforms T2 - 169th Meeting of the Acoustical Society of America AN - 1669822070; 6341646 JF - 169th Meeting of the Acoustical Society of America AU - Murphy, William Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Acoustics KW - Mobile platforms KW - Hearing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Acoustic+requirements+for+audiometric+testing+and+hearing+protector+fit-testing+with+mobile+platforms&rft.au=Murphy%2C+William&rft.aulast=Murphy&rft.aufirst=William&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Integrated microRNA, mRNA, and protein expression profiling reveals microRNA regulatory networks in rat kidney treated with a carcinogenic dose of aristolochic acid. AN - 1686996850; 25952319 AB - Aristolochic Acid (AA), a natural component of Aristolochia plants that is found in a variety of herbal remedies and health supplements, is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Given that microRNAs (miRNAs) are involved in cancer initiation and progression and their role remains unknown in AA-induced carcinogenesis, we examined genome-wide AA-induced dysregulation of miRNAs as well as the regulation of miRNAs on their target gene expression in rat kidney. We treated rats with 10 mg/kg AA and vehicle control for 12 weeks and eight kidney samples (4 for the treatment and 4 for the control) were used for examining miRNA and mRNA expression by deep sequencing, and protein expression by proteomics. AA treatment resulted in significant differential expression of miRNAs, mRNAs and proteins as measured by both principal component analysis (PCA) and hierarchical clustering analysis (HCA). Specially, 63 miRNAs (adjusted p value 1.5), 6,794 mRNAs (adjusted p value 2.0), and 800 proteins (fold change > 2.0) were significantly altered by AA treatment. The expression of 6 selected miRNAs was validated by quantitative real-time PCR analysis. Ingenuity Pathways Analysis (IPA) showed that cancer is the top network and disease associated with those dysregulated miRNAs. To further investigate the influence of miRNAs on kidney mRNA and protein expression, we combined proteomic and transcriptomic data in conjunction with miRNA target selection as confirmed and reported in miRTarBase. In addition to translational repression and transcriptional destabilization, we also found that miRNAs and their target genes were expressed in the same direction at levels of transcription (169) or translation (227). Furthermore, we identified that up-regulation of 13 oncogenic miRNAs was associated with translational activation of 45 out of 54 cancer-related targets. Our findings suggest that dysregulated miRNA expression plays an important role in AA-induced carcinogenesis in rat kidney, and that the integrated approach of multiple profiling provides a new insight into a post-transcriptional regulation of miRNAs on their target repression and activation in a genome-wide scale. JF - BMC genomics AU - Li, Zhiguang AU - Qin, Taichun AU - Wang, Kejian AU - Hackenberg, Michael AU - Yan, Jian AU - Gao, Yuan AU - Yu, Li-Rong AU - Shi, Leming AU - Su, Zhenqiang AU - Chen, Tao AD - Institute of Cancer Stem Cell, Second Affiliated Hospital, Cancer Center, Dalian Medical University, Dalian, 116044, China. zhiguangli@dlmedu.edu.cn. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. qincharles1@gmail.com. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. kejian.wang.bio@gmail.com. ; Genetics Department, Facultad de Ciencias, Universidad de Granada, Granada, 18071, Spain. mlhack@gmail.com. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. jian.yan@fda.hhs.gov. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. yuan.gao@fda.hhs.gov. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. LiRong.Yu@fda.hhs.gov. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. leming.shi@gmail.com. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. Zhenqiang.Su@fda.hhs.gov. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. tao.chen@fda.hhs.gov. Y1 - 2015/05/08/ PY - 2015 DA - 2015 May 08 SP - 365 VL - 16 KW - Aristolochic Acids KW - 0 KW - Carcinogens KW - MicroRNAs KW - RNA, Messenger KW - RNA, Neoplasm KW - aristolochic acid I KW - 94218WFP5T KW - Index Medicus KW - Rats KW - Animals KW - Gene Regulatory Networks -- drug effects KW - Proteomics KW - RNA, Messenger -- analysis KW - Molecular Sequence Data KW - Sequence Analysis, RNA KW - MicroRNAs -- analysis KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Male KW - High-Throughput Nucleotide Sequencing KW - Kidney Neoplasms -- genetics KW - Kidney -- metabolism KW - Aristolochic Acids -- toxicity KW - Kidney Neoplasms -- metabolism KW - Kidney -- drug effects KW - Carcinogens -- toxicity KW - Kidney Neoplasms -- etiology KW - RNA, Neoplasm -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686996850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Integrated+microRNA%2C+mRNA%2C+and+protein+expression+profiling+reveals+microRNA+regulatory+networks+in+rat+kidney+treated+with+a+carcinogenic+dose+of+aristolochic+acid.&rft.au=Li%2C+Zhiguang%3BQin%2C+Taichun%3BWang%2C+Kejian%3BHackenberg%2C+Michael%3BYan%2C+Jian%3BGao%2C+Yuan%3BYu%2C+Li-Rong%3BShi%2C+Leming%3BSu%2C+Zhenqiang%3BChen%2C+Tao&rft.aulast=Li&rft.aufirst=Zhiguang&rft.date=2015-05-08&rft.volume=16&rft.issue=&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2Fs12864-015-1516-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-11 N1 - Date created - 2015-06-05 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - GSE54338; GENBANK N1 - SuppNotes - Cited By: Mol Cell. 2007 Jul 6;27(1):91-105 [17612493] Science. 2007 Dec 21;318(5858):1931-4 [18048652] Nature. 2008 Jan 10;451(7175):147-52 [18185580] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1608-13 [18227514] Nat Biotechnol. 2008 Apr;26(4):462-9 [18362881] Nature. 2008 Apr 17;452(7189):872-6 [18421352] Nat Rev Genet. 2009 Jan;10(1):57-63 [19015660] J Proteomics. 2011 Nov 18;74(12):2745-59 [21884834] J Proteomics. 2011 Nov 18;74(12):2549-53 [22015715] Nephrology (Carlton). 2012 Jul;17(5):522-3 [22725717] Expert Rev Proteomics. 2012 Oct;9(5):549-59 [23194271] Proteomics. 2013 Feb;13(3-4):558-67 [23125164] Neoplasia. 2013 Feb;15(2):218-30 [23441135] Cancer Sci. 2013 Mar;104(3):304-12 [23176581] Ann Intern Med. 2013 Mar 19;158(6):469-77 [23552405] Genet Test Mol Biomarkers. 2013 Nov;17(11):807-13 [23984644] Nucleic Acids Res. 2014 Jan;42(Database issue):D78-85 [24304892] Mutat Res. 2009 Apr 26;663(1-2):1-6 [19428366] Mol Carcinog. 2009 Jun;48(6):479-87 [18942116] Int J Cancer. 2009 Jul 15;125(2):446-52 [19384944] Nucleic Acids Res. 2009 Jul;37(Web Server issue):W68-76 [19433510] Methods Mol Biol. 2009;563:379-98 [19597796] BMC Genomics. 2009;10:365 [19660143] Nature. 2009 Aug 20;460(7258):1011-5 [19587683] Nat Biotechnol. 2009 Sep;27(9):847-50 [19668243] Genome Biol. 2009;10(8):R83 [19682367] Cell Death Differ. 2010 Feb;17(2):193-9 [19461653] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2010 Apr;28(2):89-124 [20552498] Nucleic Acids Res. 2011 Jan;39(Database issue):D163-9 [21071411] Genome Biol. 2010;11(10):R106 [20979621] Curr Mol Med. 2011 Mar;11(2):93-109 [21342132] BMC Bioinformatics. 2014;15 Suppl 1:S4 [24564296] Am J Pathol. 2014 Apr;184(4):996-1009 [24508230] Bioinformatics. 2001 Jun;17(6):509-19 [11395427] Mutagenesis. 2002 Jul;17(4):265-77 [12110620] Pharmazie. 2002 Oct;57(10):686-9 [12426949] Cell. 2003 Jun 13;113(6):673-6 [12809598] Plant Cell. 2003 Nov;15(11):2730-41 [14555699] Nature. 2003 Dec 18;426(6968):845-9 [14685240] Cell. 2004 Jan 23;116(2):281-97 [14744438] Nat Rev Genet. 2004 May;5(5):396-400 [15143321] PLoS Biol. 2004 Nov;2(11):e363 [15502875] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Toxicol Lett. 2006 Sep 10;165(3):250-6 [16764999] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945] Mutat Res. 2006 Dec 1;602(1-2):83-91 [17010389] Trends Mol Med. 2006 Dec;12(12):580-7 [17071139] Cell. 2007 Mar 23;128(6):1105-18 [17382880] Mutat Res. 2007 Jun 1;619(1-2):30-7 [17343880] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12864-015-1516-2 ER - TY - CPAPER T1 - Novel methods for measuring antibody affinity, epitope diversity, and cross-reactivity in human vaccine trials T2 - 2015 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2015) AN - 1669823281; 6340175 JF - 2015 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2015) AU - Golding, Hana Y1 - 2015/05/08/ PY - 2015 DA - 2015 May 08 KW - Antibodies KW - Cross-reactivity KW - Species diversity KW - Disease control KW - Vaccines KW - Clinical trials KW - Epitopes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2015%29&rft.atitle=Novel+methods+for+measuring+antibody+affinity%2C+epitope+diversity%2C+and+cross-reactivity+in+human+vaccine+trials&rft.au=Golding%2C+Hana&rft.aulast=Golding&rft.aufirst=Hana&rft.date=2015-05-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://immunology2015.org/program/index.html?loc=nav LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - A rapid liquid chromatography determination of free formaldehyde in cod AN - 1727679732; PQ0001423924 AB - A rapid method for the determination of free formaldehyde in cod is described. It uses a simple water extraction of formaldehyde which is then derivatised with 2,4-dinitrophenylhydrazine (DNPH) to form a sensitive and specific chromophore for high-performance liquid chromatography (HPLC) detection. Although this formaldehyde derivative has been widely used in past tissue analysis, this paper describes an improved derivatisation procedure. The formation of the DNPH formaldehyde derivative has been shortened to 2 min and a stabilising buffer has been added to the derivative to increase its stability. The average recovery of free formaldehyde in spiked cod was 63% with an RSD of 15% over the range of 25-200 mg kg super(-1) (n = 48). The HPLC procedure described here was also compared to a commercial qualitative procedure - a swab test for the determination of free formaldehyde in fish. Several positive samples were compared by both methods. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Storey, Joseph M AU - Andersen, Wendy C AU - Heise, Andrea AU - Turnipseed, Sherri B AU - Lohne, Jack AU - Thomas, Terri AU - Madson, Mark AD - US Food and Drug Administration, Animal Drugs Research Center, Denver, CO 80225, USA Y1 - 2015/05/04/ PY - 2015 DA - 2015 May 04 SP - 657 EP - 664 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 5 SN - 1944-0049, 1944-0049 KW - Toxicology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - High-performance liquid chromatography KW - Risk assessment KW - Molecular structure KW - Marine KW - Pollution detection KW - Chromatographic techniques KW - Formaldehyde KW - Chromophores KW - Food contamination KW - Marine fish KW - Food additives KW - Liquid chromatography KW - Commercial species KW - O 5080:Legal/Governmental KW - X 24320:Food Additives & Contaminants KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727679732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=A+rapid+liquid+chromatography+determination+of+free+formaldehyde+in+cod&rft.au=Storey%2C+Joseph+M%3BAndersen%2C+Wendy+C%3BHeise%2C+Andrea%3BTurnipseed%2C+Sherri+B%3BLohne%2C+Jack%3BThomas%2C+Terri%3BMadson%2C+Mark&rft.aulast=Storey&rft.aufirst=Joseph&rft.date=2015-05-04&rft.volume=32&rft.issue=5&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1020530 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Molecular structure; Marine fish; Food additives; Pollution detection; Chromatographic techniques; Commercial species; Risk assessment; High-performance liquid chromatography; Liquid chromatography; Formaldehyde; Chromophores; Food contamination; Marine DO - http://dx.doi.org/10.1080/19440049.2015.1020530 ER - TY - JOUR T1 - Comparison of X-ray Powder Diffraction and Solid-State Nuclear Magnetic Resonance in Estimating Crystalline Fraction of Tacrolimus in Sustained-Release Amorphous Solid Dispersion and Development of Discriminating Dissolution Method AN - 1837338156; PQ0001392688 AB - The focus of present investigation was to explore X-ray powder diffraction (XRPD) and solid-state nuclear magnetic resonance (ssNMR) techniques for amorphous and crystalline tacrolimus quantification in the sustained-release amorphous solid dispersion (ASD), and to propose discriminating dissolution method that can detect crystalline drug. The ASD and crystalline physical mixture was mixed in various proportions to make sample matrices containing 0%-100% crystalline-amorphous tacrolimus. Partial-least-square regression and principle component regression were applied to the spectral data. Dissolution of the ASD in the US FDA recommended dissolution medium with and without surfactant was performed. R super(2) > 0.99 and slope was close to one for all the models. Root-mean-square of prediction, standard error of prediction, and bias were higher in ssNMR-based models when compared with XRPD data models. Dissolution of the ASD decreased with an increase in the crystalline tacrolimus in the formulations. Furthermore, detection of crystalline tacrolimus in the ASD was progressively masked with an increase in the surfactant level in the dissolution medium. XRPD and ssNMR can be used equally to quantitate the crystalline and amorphous fraction of tacrolimus in the ASD with good accuracy; however, ssNMR data collection time is excessively long, and minimum surfactant level in the dissolution medium maximizes detection of crystalline reversion in the formulation. copyright 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:1777-1786, 2015 JF - Journal of Pharmaceutical Sciences AU - Rahman, Ziyaur AU - Bykadi, Srikant AU - Siddiqui, Akhtar AU - Khan, Mansoor A AD - Division of Product Quality and Research, office of Testing and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 1777 EP - 1786 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 5 SN - 0022-3549, 0022-3549 KW - Toxicology Abstracts KW - Powder KW - Data processing KW - Reversion KW - Data collections KW - Tacrolimus KW - Controlled release KW - Models KW - Ionizing radiation KW - Dissolution KW - N.M.R. KW - Diffraction KW - Drugs KW - Surfactants KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837338156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Comparison+of+X-ray+Powder+Diffraction+and+Solid-State+Nuclear+Magnetic+Resonance+in+Estimating+Crystalline+Fraction+of+Tacrolimus+in+Sustained-Release+Amorphous+Solid+Dispersion+and+Development+of+Discriminating+Dissolution+Method&rft.au=Rahman%2C+Ziyaur%3BBykadi%2C+Srikant%3BSiddiqui%2C+Akhtar%3BKhan%2C+Mansoor+A&rft.aulast=Rahman&rft.aufirst=Ziyaur&rft.date=2015-05-01&rft.volume=104&rft.issue=5&rft.spage=1777&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24400 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Powder; Data processing; Reversion; Tacrolimus; Data collections; Controlled release; Models; Ionizing radiation; Dissolution; N.M.R.; Diffraction; Surfactants; Drugs DO - http://dx.doi.org/10.1002/jps.24400 ER - TY - JOUR T1 - Retrospective cohort study of liver transplantation in the United Kingdom between 1994 and 2010: the impact of hepatitis C infection AN - 1761663319; 2011-880124 AB - Background: Liver transplantation is an important and established treatment option for chronic hepatitis C virus (HCV) related end-stage liver disease (HCV-related ESLD). This study describes trends in elective liver transplantation among persons with HCV-related ESLD. Study design: Retrospective cohort. Methods: Analyses of United Kingdom (UK) Transplant Registry data for the period 1994 to 2010, with follow-up information extending to 2011. Results: Annual registrations for liver transplantation increased linearly and alcoholic liver cirrhosis (2075, 24%) and HCV-related ESLD (1213, 14%) were the most common indications. HCV-related ESLD patients were mainly aged 40-49 years (32%) and 50-59 years (43%); males (76%); and of white ethnicity (74%). Overall, 75% (956/1213) received a liver transplant with a linear increase over the period (OR 1.11, 95% CI 1.08, 1.13). Pre transplant mortality was unchanged (adjusted OR 1.0,95% CI 0.96, 1.05) and post-transplant mortality decreased in both HCV-related (adjusted OR 0.77, 95% CI 0.68, 0.88) and non-HCV-related ESLD (adjusted OR 0.82, 95% CI 0.75, 0.89) patients. Conclusion: The increase in demand for and receipt of liver transplants among persons with HCV-related ESLD requires coordinated efforts to increase not only organ donation, but investment in HCV prevention programmes and improved access to hepatitis C treatment services. [Copyright Elsevier B.V.] JF - Public Health AU - Edeghere, O AU - Verlander, N Q AU - Aboulhab, J AU - Costella, A AU - Harris, H E AU - Balogun, M A AU - Ramsay, M E AD - Field Epidemiology Service, Public Health England, UK obaghe.edeghere@phe.gov.uk Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 509 EP - 516 PB - Elsevier Ltd, The Netherlands VL - 129 IS - 5 SN - 0033-3506, 0033-3506 KW - Hepatitis C Liver transplantation Liver cirrhosis Retrospective studies End stage liver disease Clinical outcome KW - Whites KW - Hepatitis KW - Mortality KW - Investments KW - Donation of organs, tissues, etc. KW - Patients KW - Diseases KW - Ethnic groups KW - United Kingdom KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761663319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health&rft.atitle=Retrospective+cohort+study+of+liver+transplantation+in+the+United+Kingdom+between+1994+and+2010%3A+the+impact+of+hepatitis+C+infection&rft.au=Edeghere%2C+O%3BVerlander%2C+N+Q%3BAboulhab%2C+J%3BCostella%2C+A%3BHarris%2C+H+E%3BBalogun%2C+M+A%3BRamsay%2C+M+E&rft.aulast=Edeghere&rft.aufirst=O&rft.date=2015-05-01&rft.volume=129&rft.issue=5&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Public+Health&rft.issn=00333506&rft_id=info:doi/10.1016%2Fj.puhe.2015.01.024 LA - English DB - PAIS Index N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United Kingdom; Hepatitis; Mortality; Patients; Donation of organs, tissues, etc.; Whites; Ethnic groups; Investments; Diseases DO - http://dx.doi.org/10.1016/j.puhe.2015.01.024 ER - TY - JOUR T1 - Numerical modeling of water spray suppression of conveyor belt fires in a large-scale tunnel AN - 1744681908; PQ0001936446 AB - Conveyor belt fires in an underground mine pose a serious life threat to miners. Water sprinkler systems are usually used to extinguish underground conveyor belt fires, but because of the complex interaction between conveyor belt fires and mine ventilation airflow, more effective engineering designs are needed for the installation of water sprinkler systems. A computational fluid dynamics (CFD) model was developed to simulate the interaction between the ventilation airflow, the belt flame spread, and the water spray system in a mine entry. The CFD model was calibrated using test results from a large-scale conveyor belt fire suppression experiment. Simulations were conducted using the calibrated CFD model to investigate the effects of sprinkler location, water flow rate, and sprinkler activation temperature on the suppression of conveyor belt fires. The sprinkler location and the activation temperature were found to have a major effect on the suppression of the belt fire, while the water flow rate had a minor effect. JF - Process Safety and Environmental Protection AU - Yuan, Liming AU - Smith, Alex C AD - Mine Safety and Health Research, National Institute for Occupational Safety and Health, P.O. Box 18070, Pittsburgh, PA 15236, USA PY - 2015 SP - 93 EP - 101 PB - Institution of Chemical Engineers, Davis Bldg. Rugby Warwickshire CV21 3HQ United Kingdom VL - 95 SN - 0957-5820, 0957-5820 KW - Mechanical & Transportation Engineering Abstracts (MT); Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE); ANTE: Abstracts in New Technologies and Engineering (AN) KW - Conveyor belt fires KW - Computational fluid dynamics KW - Water sprinkler systems KW - Flame spread KW - Ventilation KW - Activation KW - Fires KW - Mathematical models KW - Computer simulation KW - Water flow KW - Sprinklers KW - Belt conveyors KW - Yes:(AN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1744681908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Process+Safety+and+Environmental+Protection&rft.atitle=Numerical+modeling+of+water+spray+suppression+of+conveyor+belt+fires+in+a+large-scale+tunnel&rft.au=Yuan%2C+Liming%3BSmith%2C+Alex+C&rft.aulast=Yuan&rft.aufirst=Liming&rft.date=2015-05-01&rft.volume=95&rft.issue=&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Process+Safety+and+Environmental+Protection&rft.issn=09575820&rft_id=info:doi/10.1016%2Fj.psep.2015.02.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 23 N1 - Last updated - 2016-02-03 DO - http://dx.doi.org/10.1016/j.psep.2015.02.018 ER - TY - JOUR T1 - Rapid determination of plasmonic nanoparticle agglomeration status in blood AN - 1732826650; PQ0002223918 AB - Plasmonic nanomaterials as drug delivery or bio-imaging agents are typically introduced to biological systems through intravenous administration. However, the potential for agglomeration of nanoparticles in biological systems could dramatically affect their pharmacokinetic profile and toxic potential. Development of rapid screening methods to evaluate agglomeration is urgently needed to monitor the physical nature of nanoparticles as they are introduced into blood. Here, we establish novel methods using darkfield microscopy with hyperspectral detection (hsDFM), single particle inductively-coupled plasma mass spectrometry (spICP-MS), and confocal Raman microscopy (cRM) to discriminate gold nanoparticles (AuNPs) and their agglomerates in blood. Rich information about nanoparticle agglomeration in situ is provided by hsDFM monitoring of the plasmon resonance of primary nanoparticles and their agglomerates in whole blood; cRM is an effective complement to hsDFM to detect AuNP agglomerates in minimally manipulated samples. The AuNPs and the particle agglomerates were further distinguished in blood for the first time by quantification of particle mass using spICP-MS with excellent sensitivity and specificity. Furthermore, the agglomeration status of synthesized and commercial NPs incubated in blood was successfully assessed using the developed methods. Together, these complementary methods enable rapid determination of the agglomeration status of plasmonic nanomaterials in biological systems, specifically blood. JF - Biomaterials AU - Jenkins, Samir V AU - Qu, Haiou AU - Mudalige, Thilak AU - Ingle, Taylor M AU - Wang, Rongrong AU - Wang, Feng AU - Howard, Paul C AU - Chen, Jingyi AU - Zhang, Yongbin AD - NCTR/ORA Nanotechnology Core Facility, U.S. Food and Drug Administration, Jefferson, AR 72079, United States Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 226 EP - 237 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 51 SN - 0142-9612, 0142-9612 KW - Biotechnology and Bioengineering Abstracts KW - Nanoparticles KW - Gold KW - Silver KW - Blood KW - Darkfield microscopy KW - Single particle ICP-MS KW - Drug delivery KW - Intravenous administration KW - nanoparticles KW - Mass spectroscopy KW - Pharmacokinetics KW - Agglomeration KW - nanotechnology KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732826650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Rapid+determination+of+plasmonic+nanoparticle+agglomeration+status+in+blood&rft.au=Jenkins%2C+Samir+V%3BQu%2C+Haiou%3BMudalige%2C+Thilak%3BIngle%2C+Taylor+M%3BWang%2C+Rongrong%3BWang%2C+Feng%3BHoward%2C+Paul+C%3BChen%2C+Jingyi%3BZhang%2C+Yongbin&rft.aulast=Jenkins&rft.aufirst=Samir&rft.date=2015-05-01&rft.volume=51&rft.issue=&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=01429612&rft_id=info:doi/10.1016%2Fj.biomaterials.2015.01.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-11-13 N1 - SubjectsTermNotLitGenreText - Drug delivery; Blood; Intravenous administration; Gold; nanoparticles; Pharmacokinetics; Mass spectroscopy; nanotechnology; Agglomeration DO - http://dx.doi.org/10.1016/j.biomaterials.2015.01.072 ER - TY - JOUR T1 - Pseudozyma aphidis Induces Salicylic-Acid-Independent Resistance to Clavibacter michiganensis in Tomato Plants AN - 1722168211; PQ0002041288 AB - The ability of plant pathogens to rapidly develop resistance to commonly used pesticides challenges efforts to maximize crop production. Fungal biocontrol agents have become an important alternative to chemical fungicides as a result of environmental concerns regarding conventional pesticides, including resistance issues. The complex mode of action of biocontrol agents reduces the likelihood that pathogens will develop resistance to them. We recently isolated a unique, biologically active isolate of the epiphytic fungus Pseudozyma aphidis. We show that the extracellular metabolites secreted by our P. aphidis isolate can inhibit Xanthomonas campestris pv. vesicatoria, X. campestris pv. campestris, Pseudomonas syringae pv. tomato, Erwinia amylovora, Clavibacter michiganensis, and Agrobacterium tumefaciens in vitro. Moreover, application of Pseudozyma aphidis spores on tomato plants in the greenhouse significantly reduced (by 60%) the incidence of bacterial wilt and canker disease caused by C. michiganensis subsp. michiganensis on those plants as well as disease severity by 35%. Furthermore, infected plants treated with P. aphidis were 25% taller than control infected plants. We found that P. aphidis activates PR1a-and other pathogenesis-related genes in tomato plants-and can trigger an induced-resistance response against C. michiganensis that proceeds in a salicylic-acid-independent manner, as shown using NahG-transgenic tomato plants. JF - Plant Disease AU - Barda, Omer AU - Shalev, Or AU - Alster, Shanee AU - Buxdorf, Kobi AU - Gafni, Aviva AU - Levy, Maggie AD - Department of Plant Pathology and Microbiology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel, maggie.Levy@mail.huji.ac.il PY - 2015 SP - 621 EP - 626 PB - American Phytopathological Society, 3340 Pilot Knob Road St. Paul MN 55121-2097 United States VL - 99 IS - 5 SN - 0191-2917, 0191-2917 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Biological control KW - Canker KW - Plant diseases KW - Metabolites KW - Pathogens KW - Greenhouses KW - Agrobacterium tumefaciens KW - Lycopersicon esculentum KW - Crop production KW - Clavibacter michiganensis KW - Pseudozyma KW - Pesticides KW - Fungicides KW - Xanthomonas campestris KW - Spores KW - Erwinia amylovora KW - Pseudomonas syringae KW - Wilt KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - J 02320:Cell Biology KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722168211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plant+Disease&rft.atitle=Pseudozyma+aphidis+Induces+Salicylic-Acid-Independent+Resistance+to+Clavibacter+michiganensis+in+Tomato+Plants&rft.au=Barda%2C+Omer%3BShalev%2C+Or%3BAlster%2C+Shanee%3BBuxdorf%2C+Kobi%3BGafni%2C+Aviva%3BLevy%2C+Maggie&rft.aulast=Barda&rft.aufirst=Omer&rft.date=2015-05-01&rft.volume=99&rft.issue=5&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Plant+Disease&rft.issn=01912917&rft_id=info:doi/10.1094%2FPDIS-04-14-0377-RE LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Canker; Crop production; Biological control; Plant diseases; Fungicides; Pesticides; Metabolites; Pathogens; Spores; Wilt; Greenhouses; Lycopersicon esculentum; Agrobacterium tumefaciens; Pseudozyma; Clavibacter michiganensis; Xanthomonas campestris; Erwinia amylovora; Pseudomonas syringae DO - http://dx.doi.org/10.1094/PDIS-04-14-0377-RE ER - TY - JOUR T1 - Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats AN - 1712572325; PQ0001942528 AB - Silver nanoparticles (AgNP) are widely used for their antibacterial properties. Incorporation of AgNP into food-related products and health supplements represents a potential route for oral exposure to AgNP; however, the effects of such exposure on the gastrointestinal system are mostly unknown. This study evaluated changes in the populations of intestinal-microbiota and intestinal-mucosal gene expression in Sprague-Dawley rats (both male and female) that were gavaged orally with discrete sizes of AgNP (10, 75 and 110 nm) and silver acetate. Doses of AgNP (9, 18 and 36 mg/kg body weight/day) and silver acetate (100, 200 and 400 mg/kg body weight/day) were divided and administered to rats twice daily (~10 h apart) for 13 weeks. The results indicate that AgNP prompted size-and dose-dependent changes to ileal-mucosal microbial populations, as well as, intestinal gene expression and induced an apparent shift in the gut microbiota toward greater proportions of Gram-negative bacteria. DNA-based analyses revealed that exposure to 10nm AgNP and low-dose silver acetate caused a decrease in populations of Firmicutes phyla, along with a decrease in the Lactobacillus genus. Analysis of host gene expression demonstrated that smaller sizes and lower doses of AgNP exposure prompted the decreased expression of important immunomodulatory genes, including MUC3, TLR2, TLR4, GPR43 and FOXP3. Gender-specific effects to AgNP exposure were more prominentforthe gut-associated immune responses. These results indicate that the oral exposure to AgNP alter mucosa-associated microbiota and modulate the gut-associated immune response and the overall homeostasis ofthe intestinal tract. JF - Nanotoxicology AU - Williams, Katherine AU - Milner, Jessica AU - Boudreau, Mary D AU - Gokulan, Kuppan AU - Cerniglia, Carl E AU - Khare, Sangeeta AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, sangeeta.khare@fda.hhs.gov PY - 2015 SP - 279 EP - 289 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 9 IS - 3 SN - 1743-5390, 1743-5390 KW - Immunology Abstracts; Toxicology Abstracts KW - Bacteria KW - microbiome KW - mucosal immunity KW - Food KW - TLR2 protein KW - Firmicutes KW - Homeostasis KW - Ileum KW - Immunomodulation KW - Acetic acid KW - Gene expression KW - Intestinal microflora KW - Lactobacillus KW - Digestive tract KW - Body weight KW - Foxp3 protein KW - Gram-negative bacteria KW - Intestine KW - Immune response KW - nanoparticles KW - Silver KW - TLR4 protein KW - Toll-like receptors KW - F 06910:Microorganisms & Parasites KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712572325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Effects+of+subchronic+exposure+of+silver+nanoparticles+on+intestinal+microbiota+and+gut-associated+immune+responses+in+the+ileum+of+Sprague-Dawley+rats&rft.au=Williams%2C+Katherine%3BMilner%2C+Jessica%3BBoudreau%2C+Mary+D%3BGokulan%2C+Kuppan%3BCerniglia%2C+Carl+E%3BKhare%2C+Sangeeta&rft.aulast=Williams&rft.aufirst=Katherine&rft.date=2015-05-01&rft.volume=9&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2014.921346 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Food; TLR2 protein; Ileum; Homeostasis; Acetic acid; Immunomodulation; Gene expression; Intestinal microflora; Digestive tract; Body weight; Foxp3 protein; Gram-negative bacteria; Intestine; Immune response; TLR4 protein; Silver; nanoparticles; Toll-like receptors; Lactobacillus; Firmicutes DO - http://dx.doi.org/10.3109/17435390.2014.921346 ER - TY - JOUR T1 - Intradermal Inactivated Poliovirus Vaccine: A Preclinical Dose-Finding Study AN - 1709176604; PQ0001745366 AB - Intradermal delivery of vaccines has been shown to result in dose sparing. We tested the ability of fractional doses of inactivated poliovirus vaccine (IPV) delivered intradermally to induce levels of serum poliovirus-neutralizing antibodies similar to immunization through the intramuscular route. Immunogenicity of fractional doses of IPV was studied by comparing intramuscular and intradermal immunization of Wistar rats using NanoPass MicronJet600 microneedles. Intradermal delivery of partial vaccine doses induced antibodies at titers comparable to those after immunization with full human dose delivered intramuscularly. The results suggest that intradermal delivery of IPV may lead to dose-sparing effect and reduction of the vaccination cost. JF - Journal of Infectious Diseases AU - Kouiavskaia, Diana AU - Mirochnitchenko, Olga AU - Dragunsky, Eugenia AU - Kochba, Efrat AU - Levin, Yotam AU - Troy, Stephanie AU - Chumakov, Konstantin AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, konstantin.chumakov@fda.hhs.gov Y1 - 2015/05/01/ PY - 2015 DA - 2015 May 01 SP - 1447 EP - 1450 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 211 IS - 9 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - inactivated poliovirus vaccine KW - intradermal KW - immunogenicity KW - dose sparing KW - Rats KW - Poliovirus KW - Antibodies KW - Infectious diseases KW - Immunogenicity KW - Vaccines KW - Immunization KW - V 22350:Immunology KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709176604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Intradermal+Inactivated+Poliovirus+Vaccine%3A+A+Preclinical+Dose-Finding+Study&rft.au=Kouiavskaia%2C+Diana%3BMirochnitchenko%2C+Olga%3BDragunsky%2C+Eugenia%3BKochba%2C+Efrat%3BLevin%2C+Yotam%3BTroy%2C+Stephanie%3BChumakov%2C+Konstantin&rft.aulast=Kouiavskaia&rft.aufirst=Diana&rft.date=2015-05-01&rft.volume=211&rft.issue=9&rft.spage=1447&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu624 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Antibodies; Immunogenicity; Vaccines; Rats; Poliovirus; Infectious diseases; Immunization DO - http://dx.doi.org/10.1093/infdis/jiu624 ER - TY - JOUR T1 - Intention of Nursing Students to Work in Geriatrics AN - 1708853440 AB - The current study examined factors related to nursing students' intention to work in geriatrics upon graduation. A cross-sectional, descriptive design was used. A random sample of 200 nursing students completed a questionnaire based on the Theory of Planned Behavior and Kogan's Attitudes Toward Old People Scale. Participants expressed low intention to work in geriatrics upon graduation. Results of a multiple linear regression indicated that students' attitudes toward working in geriatrics and normative and control beliefs were found to be predictors of this intention. Additionally, male and religious students were more inclined to work in geriatrics. The current study indicated that nursing students' attitudes toward working in geriatrics were significantly predictive of their intention to work in this field upon graduation. [Res Gerontol Nurs. 2015; 8(3):140-147.] JF - Research in Gerontological Nursing AU - Ben Natan, Merav AU - Danino, Sharon AU - Freundlich, Nelli AU - Barda, Ayelet AU - Yosef, Racheli Mor Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 140 EP - 147 CY - Thorofare PB - SLACK INCORPORATED VL - 8 IS - 3 SN - 19404921 KW - Gerontology And Geriatrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708853440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Gerontological+Nursing&rft.atitle=Intention+of+Nursing+Students+to+Work+in+Geriatrics&rft.au=Ben+Natan%2C+Merav%3BDanino%2C+Sharon%3BFreundlich%2C+Nelli%3BBarda%2C+Ayelet%3BYosef%2C+Racheli+Mor&rft.aulast=Ben+Natan&rft.aufirst=Merav&rft.date=2015-05-01&rft.volume=8&rft.issue=3&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Research+in+Gerontological+Nursing&rft.issn=19404921&rft_id=info:doi/10.3928%2F19404921-20150219-03 LA - English DB - ProQuest Central N1 - Copyright - Copyright 2015, SLACK Incorporated N1 - Last updated - 2016-04-02 DO - http://dx.doi.org/10.3928/19404921-20150219-03 ER - TY - JOUR T1 - Assessment of benefits and risks in development of targeted therapies for cancer--The view of regulatory authorities. AN - 1691281134; 25481691 AB - Drug licensing and approval decisions involve the balancing of benefits against the risks (harms) in the presence of uncertainty. Typically, the benefits are estimated from primary efficacy endpoints from confirmatory (phase III) clinical trials although exceptions where promising early data from single-arm studies have led to accelerated approvals are not uncommon, particularly for cancer drugs. The challenge for regulators is to balance early evidence of efficacy that might support approval versus the need to establish clinical benefit based on conclusive evidence. Targeted agents offer the promise that knowledge about the mechanism of the disease will help identify patients with tumors likely to respond, resulting in higher efficacy and less toxicity, and earlier regulatory decisions based on convincing evidence of clinical benefit. In this paper, we describe methods and examples of benefit-risk assessment of targeted drugs, recent initiatives from EMA and FDA on improving communication about benefits and risks, and discuss future steps. Published by Elsevier B.V. JF - Molecular oncology AU - Pignatti, Francesco AU - Jonsson, Bertil AU - Blumenthal, Gideon AU - Justice, Robert AD - European Medicines Agency (EMA), London, United Kingdom. Electronic address: francesco.pignatti@ema.europa.eu. ; Läkemedelsverket, Uppsala, Sweden. ; Food and Drug Administration (FDA), Silver Spring, MD, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 1034 EP - 1041 VL - 9 IS - 5 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Benefit-risk balance KW - Drug regulation KW - Targeted therapies KW - Humans KW - Risk Assessment KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691281134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+oncology&rft.atitle=Assessment+of+benefits+and+risks+in+development+of+targeted+therapies+for+cancer--The+view+of+regulatory+authorities.&rft.au=Pignatti%2C+Francesco%3BJonsson%2C+Bertil%3BBlumenthal%2C+Gideon%3BJustice%2C+Robert&rft.aulast=Pignatti&rft.aufirst=Francesco&rft.date=2015-05-01&rft.volume=9&rft.issue=5&rft.spage=1034&rft.isbn=&rft.btitle=&rft.title=Molecular+oncology&rft.issn=1878-0261&rft_id=info:doi/10.1016%2Fj.molonc.2014.10.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-19 N1 - Date created - 2015-04-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.molonc.2014.10.003 ER - TY - JOUR T1 - Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus AN - 1683355066; PQ0001567602 AB - times Resistance to fusidic acid rose among meticillin-resistant Staphylococcus aureus (MRSA) during the 2000s. Fusidic acid is a topical and systemic antimicrobial used for the treatment of staphylococcal infections in hospitals and the community. Sales of fusidic acid and resistance rates among meticillin-resistant Staphylococcus aureus (MRSA) doubled between 1990 and 2001. For the following decade, fusidic acid resistance rates among isolates from Addenbrooke's Hospital (Cambridge, UK) were compared with national resistance rates from MRSA bacteraemia surveillance data and with antimicrobial sales data. Sales of fusidic acid remained relatively constant between 2002 and 2012, whilst fusidic acid resistance increased two- and four-fold in MRSA bacteraemias nationally and in MRSA isolates from Cambridge, respectively. A subgroup of MRSA resistant only to fusidic acid increased after 2006 by 5-fold amongst bacteraemias nationally and 17-fold (to 7.7% in 2012) amongst Cambridge MRSA isolates. All of the available local isolates from 2011 to 2012 (n = 23) were acquired in the community, were not related epidemiologically and belonged to multilocus sequence typing (MLST) groups ST1, 5, 8, 45 or 149 as revealed from analysis of whole-genome sequence data. All harboured the fusC gene on one of six distinct staphylococcal cassette chromosome (SCC) elements, four of which were dual-resistance chimeras that encoded beta -lactam and fusidic acid resistance. In summary, fusidic acid-resistant MRSA increased in prevalence during the 2000s with notable rises after 2006. The development of chimeric cassettes that confer dual resistance to beta -lactams and fusidic acid demonstrates that the genetics underpinning resistance in community-associated MRSA are evolving. JF - International Journal of Antimicrobial Agents AU - Ellington, Matthew J AU - Reuter, Sandra AU - Harris, Simon R AU - Holden, Matthew TG AU - Cartwright, Edward J AU - Greaves, Daniel AU - Gerver, Sarah M AU - Hope, Russell AU - Brown, Nicholas M AU - Torok, MEstee AU - Parkhill, Julian AU - Koser, Claudio U AU - Peacock, Sharon J AD - aPublic Health England, Microbiology Services Division, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QW, UK, matthew.ellington@phe.gov.uk Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 477 EP - 484 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 45 IS - 5 SN - 0924-8579, 0924-8579 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - CA-MRSA KW - Antimicrobial resistance KW - Surveillance KW - SCC genomics KW - Data processing KW - Drug resistance KW - Bacteremia KW - Infection KW - Antimicrobial agents KW - multilocus sequence typing KW - Chimeras KW - Chromosomes KW - Fusidic acid KW - beta -Lactam antibiotics KW - Staphylococcus aureus KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683355066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Emergent+and+evolving+antimicrobial+resistance+cassettes+in+community-associated+fusidic+acid+and+meticillin-resistant+Staphylococcus+aureus&rft.au=Ellington%2C+Matthew+J%3BReuter%2C+Sandra%3BHarris%2C+Simon+R%3BHolden%2C+Matthew+TG%3BCartwright%2C+Edward+J%3BGreaves%2C+Daniel%3BGerver%2C+Sarah+M%3BHope%2C+Russell%3BBrown%2C+Nicholas+M%3BTorok%2C+MEstee%3BParkhill%2C+Julian%3BKoser%2C+Claudio+U%3BPeacock%2C+Sharon+J&rft.aulast=Ellington&rft.aufirst=Matthew&rft.date=2015-05-01&rft.volume=45&rft.issue=5&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2015.01.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Chimeras; Chromosomes; Data processing; Fusidic acid; Drug resistance; beta -Lactam antibiotics; Bacteremia; Infection; multilocus sequence typing; Antimicrobial agents; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.ijantimicag.2015.01.009 ER - TY - JOUR T1 - Seroprevalence of Antibody-Mediated, Complement-Dependent Opsonophagocytic Activity against Neisseria meningitidis Serogroup B in England AN - 1683348650; PQ0001539756 AB - The correlate of protection for the licensure of meningococcal vaccines is serum bactericidal activity. However, evidence indicates that a complex situation and other mechanisms, such as antibody-mediated, complement-dependent opsonophagocytosis (OP), may play a role in protection and should be investigated in order to understand immunity to this disease. In this study, a high-throughput flow cytometric opsonophagocytic assay (OPA) was optimized. The assay measures the presence of killed fluorescently labeled Neisseria meningitidis within human granulocytes (differentiated HL60 cells) by flow cytometry, using IgG-depleted pooled human plasma as an exogenous source of complement. This method was found to be reliable and correlated with the results of an opsonophagocytic killing assay. The OPA was used to measure OP activity in 1,878 serum samples from individuals ranging from 0 to 99 years of age against N. meningitidis strain NZ98/254 (B:4:P1.7-2,4). The levels of OP activity in individual serum samples varied greatly. OP activity showed an initial peak in the 6- to 12-month age group corresponding to a peak in disease incidence. The OP activity dropped in childhood until the late teenage years, although there was still a higher percentage of individuals with OP activity than with protective bactericidal antibody titers. OP activity reached a peak in the 30- to 39-year age group and then declined. This later peak in OP activity did not coincide with the young adults in whom peak serum bactericidal activity and disease incidence occurred. The demonstration of OP activity when disease incidence is low and when protective bactericidal antibody titers are not detected may indicate a role for OP in protection from meningococcal disease in these age groups. JF - Clinical and Vaccine Immunology AU - Humphries, Holly E AU - Brookes, Charlotte AU - Allen, Lauren AU - Kuisma, Eeva AU - Gorringe, Andrew AU - Taylor, Stephen Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 503 EP - 509 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 22 IS - 5 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Flow cytometry KW - Leukocytes (granulocytic) KW - Age KW - Antibodies KW - meningococcal disease KW - Serum bactericidal activity KW - opsonophagocytosis KW - Neisseria meningitidis KW - Vaccines KW - Immunity KW - Children KW - F 06905:Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683348650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Seroprevalence+of+Antibody-Mediated%2C+Complement-Dependent+Opsonophagocytic+Activity+against+Neisseria+meningitidis+Serogroup+B+in+England&rft.au=Humphries%2C+Holly+E%3BBrookes%2C+Charlotte%3BAllen%2C+Lauren%3BKuisma%2C+Eeva%3BGorringe%2C+Andrew%3BTaylor%2C+Stephen&rft.aulast=Humphries&rft.aufirst=Holly&rft.date=2015-05-01&rft.volume=22&rft.issue=5&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00100-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 38 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Leukocytes (granulocytic); Antibodies; Age; meningococcal disease; Serum bactericidal activity; opsonophagocytosis; Immunity; Vaccines; Children; Neisseria meningitidis DO - http://dx.doi.org/10.1128/CVI.00100-15 ER - TY - JOUR T1 - Flavoring exposure in food manufacturing AN - 1680461084; PQ0001495816 AB - Flavorings are substances that alter or enhance the taste of food. Workers in the food-manufacturing industry, where flavorings are added to many products, may be exposed to any number of flavoring compounds. Although thousands of flavoring substances are in use, little is known about most of these in terms of worker health effects, and few have occupational exposure guidelines. Exposure assessment surveys were conducted at nine food production facilities and one flavor manufacturer where a total of 105 area and 74 personal samples were collected for 13 flavoring compounds including five ketones, five aldehydes, and three acids. The majority of the samples were below the limit of detection (LOD) for most compounds. Diacetyl had eight area and four personal samples above the LOD, whereas 2,3-pentanedione had three area samples above the LOD. The detectable values ranged from 25-3124 ppb and 15-172 ppb for diacetyl and 2,3-pentanedione respectively. These values exceed the proposed National Institute for Occupational Safety and Health (NIOSH) recommended exposure limit for these compounds. The aldehydes had the most detectable samples, with each of them having >50% of the samples above the LOD. Acetaldehyde had all but two samples above the LOD, however, these samples were below the OSHA PEL. It appears that in the food-manufacturing facilities surveyed here, exposure to the ketones occurs infrequently, however levels above the proposed NIOSH REL were found. Conversely, aldehyde exposure appears to be ubiquitous. JF - Journal of Exposure Science and Environmental Epidemiology AU - Curwin, Brian D AU - Deddens, Jim A AU - McKernan, Lauralynn T AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 324 EP - 333 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 25 IS - 3 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Federal regulations KW - Safety regulations KW - Food industry KW - Food KW - Acetaldehyde KW - Guidelines KW - Occupational safety KW - Flavorings KW - Taste KW - Diacetyl KW - Ketones KW - Acids KW - Aldehydes KW - Occupational exposure KW - Food production KW - ketones KW - X 24320:Food Additives & Contaminants KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680461084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Flavoring+exposure+in+food+manufacturing&rft.au=Curwin%2C+Brian+D%3BDeddens%2C+Jim+A%3BMcKernan%2C+Lauralynn+T&rft.aulast=Curwin&rft.aufirst=Brian&rft.date=2015-05-01&rft.volume=25&rft.issue=3&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2014.52 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Food industry; Acids; Acetaldehyde; Food; Flavorings; Taste; Aldehydes; Diacetyl; Occupational exposure; ketones; Federal regulations; Safety regulations; Ketones; Occupational safety; Guidelines; Food production DO - http://dx.doi.org/10.1038/jes.2014.52 ER - TY - JOUR T1 - Persistent organic pollutants (POPs) and fibroids: results from the ENDO study AN - 1680461065; PQ0001495811 AB - To evaluate the association between persistent organic pollutants (POPs) and uterine fibroids, we used previously collected data from a cohort of women aged 18-44 years undergoing laparoscopy or laparotomy at 14 participating hospital surgical centers (n=473). POP concentrations were measured in omental fat and serum. Presence of fibroids was defined on the basis of a postoperative diagnosis (n=99). Odds ratios (OR) and 95% confidence interval (CI) for each POP by biologic medium were estimated using unconditional logistic regression adjusted for identified covariates. Concentrations were higher in omental fat than in serum for all POPs. Serum p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was the only POP associated with fibroids (per 1-SD increase in log-transformed p,p'-DDE OR (95% CI): 1.37 (1.05-1.80)). In analyses excluding women diagnosed with endometriosis, a number of polychlorinated biphenyls (PCBs) measured in omental fat were associated with fibroids (PCB 99: 1.64 (1.08, 2.49); PCB 138: 1.64 (1.03, 2.59); PCB 146: 1.54 (1.01, 2.37); PCB 153: 1.88 (1.12, 3.13); PCB 196: 1.60 (1.02, 2.51); PCB 206: 1.52 (1.01, 2.29)). Although exploratory, our study suggests that PCBs may be associated with fibroids in the absence of other gynecologic disorders such as endometriosis, but the associations varied by biologic media with more POPs emerging when quantified in fat. JF - Journal of Exposure Science and Environmental Epidemiology AU - Trabert, Britton AU - Chen, Zhen AU - Kannan, Kurunthachalam AU - Peterson, C Matthew AU - Pollack, Anna Z AU - Sun, Liping AU - Buck Louis, Germaine M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 278 EP - 285 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 25 IS - 3 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Uterus KW - Data processing KW - Laparoscopy KW - Endometriosis KW - polychlorinated biphenyls KW - Pollutants KW - Surgery KW - Persistent organic pollutants KW - PCB compounds KW - PCB KW - Hospitals KW - H 12000:Epidemiology and Public Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680461065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Persistent+organic+pollutants+%28POPs%29+and+fibroids%3A+results+from+the+ENDO+study&rft.au=Trabert%2C+Britton%3BChen%2C+Zhen%3BKannan%2C+Kurunthachalam%3BPeterson%2C+C+Matthew%3BPollack%2C+Anna+Z%3BSun%2C+Liping%3BBuck+Louis%2C+Germaine+M&rft.aulast=Trabert&rft.aufirst=Britton&rft.date=2015-05-01&rft.volume=25&rft.issue=3&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2014.31 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Uterus; Data processing; polychlorinated biphenyls; Pollutants; Laparoscopy; Endometriosis; PCB; Hospitals; Surgery; Persistent organic pollutants; PCB compounds DO - http://dx.doi.org/10.1038/jes.2014.31 ER - TY - JOUR T1 - Differential gene expression in Staphylococcus aureus exposed to Orange II and Sudan III azo dyes AN - 1680447216; PQ0001483633 AB - We previously demonstrated the effects of azo dyes and their reduction metabolites on bacterial cell growth and cell viability. In this report, the effects of Orange II and Sudan III on gene expression profiling in Staphylococcus aureus ATCC BAA 1556 were analyzed using microarray and quantitative RT-PCR technology. Upon exposure to 6 mu g/ml Orange II for 18 h, 21 genes were found to be differently expressed. Among them, 8 and 13 genes were up- and down-regulated, respectively. Most proteins encoded by these differentially expressed genes involve stress response caused by drug metabolism, oxidation, and alkaline shock indicating that S. aureus could adapt to Orange II exposure through a balance between up and down regulated gene expression. Whereas, after exposure to 6 mu g/ml Sudan III for 18 h, 57 genes were differentially expressed. In which, 51 genes were up-regulated and 6 were down-regulated. Most proteins encoded by these differentially expressed genes involve in cell wall/membrane biogenesis and biosynthesis, nutrient uptake, transport and metabolite, and stress response, suggesting that Sudan III damages the bacterial cell wall or/and membrane due to binding of the dye. Further analysis indicated that all differentially expressed genes encoded membrane proteins were up-regulated and most of them serve as transporters. The result suggested that these genes might contribute to survival, persistence and growth in the presence of Sudan III. Only one gene msrA, which plays an important role in oxidative stress resistance, was found to be down-regulated after exposure to both Orange II and Sudan III. The present results suggested that both these two azo dyes can cause stress in S. aureus and the response of the bacterium to the stress is mainly related to characteristics of the azo dyes. JF - Journal of Industrial Microbiology & Biotechnology AU - Pan, Hongmiao AU - Xu, Joshua AU - Kweon, Oh-Gew AU - Zou, Wen AU - Feng, Jinhui AU - He, Gui-Xin AU - Cerniglia, Carl E AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR, 72079-9502, USA, huizhong.chen@fda.hhs.gov Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 745 EP - 757 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 42 IS - 5 SN - 1367-5435, 1367-5435 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Gene expression KW - Shock KW - Azo dyes KW - Oxidative stress KW - Drug metabolism KW - Polymerase chain reaction KW - Metabolites KW - Membrane proteins KW - Staphylococcus aureus KW - Nutrient uptake KW - Cell walls KW - A 01360:Plant Diseases KW - J 02320:Cell Biology KW - G 07770:Bacteria KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680447216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.atitle=Differential+gene+expression+in+Staphylococcus+aureus+exposed+to+Orange+II+and+Sudan+III+azo+dyes&rft.au=Pan%2C+Hongmiao%3BXu%2C+Joshua%3BKweon%2C+Oh-Gew%3BZou%2C+Wen%3BFeng%2C+Jinhui%3BHe%2C+Gui-Xin%3BCerniglia%2C+Carl+E%3BChen%2C+Huizhong&rft.aulast=Pan&rft.aufirst=Hongmiao&rft.date=2015-05-01&rft.volume=42&rft.issue=5&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.issn=13675435&rft_id=info:doi/10.1007%2Fs10295-015-1599-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 88 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Gene expression; Shock; Oxidative stress; Azo dyes; Drug metabolism; Polymerase chain reaction; Metabolites; Membrane proteins; Nutrient uptake; Cell walls; Staphylococcus aureus DO - http://dx.doi.org/10.1007/s10295-015-1599-4 ER - TY - JOUR T1 - Effect of therapeutic femtosecond laser pulse energy, repetition rate, and numerical aperture on laser-induced second and third harmonic generation in corneal tissue AN - 1680440446; PQ0001502738 AB - Clinical therapy incorporating femtosecond laser (FSL) devices is a quickly growing field in modern biomedical technology due to their precision and ability to generate therapeutic effects with substantially less laser pulse energy. FSLs have the potential to produce nonlinear optical effects such as harmonic generation (HG), especially in tissues with significant nonlinear susceptibilities such as the cornea. HG in corneal tissue has been demonstrated in nonlinear harmonic microscopy using low-power FSLs. Furthermore, the wavelength ranges of harmonic spectral emissions generated in corneal tissues are known to be phototoxic above certain intensities. We have investigated how the critical FSL parameters pulse energy, pulse repetition rate, and numerical aperture influence both second (SHG) and third harmonic generation (THG) in corneal tissue. Experimental results demonstrated corresponding increases in HG intensity with increasing repetition rate and numerical aperture. HG duration decreased with increasing repetition rate and pulse energy. The data also demonstrated a significant difference in HG between FSL parameters representing the two most common classes of FSL therapeutic devices. JF - Lasers in Medical Science AU - Calhoun, William R AU - Ilev, Ilko K AD - Optical Therapeutics and Medical Nanophotonics Laboratory, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA, william.calhoun@fda.hhs.gov Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 1341 EP - 1346 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 30 IS - 4 SN - 0268-8921, 0268-8921 KW - Biotechnology and Bioengineering Abstracts KW - Repetition KW - Data processing KW - Cornea KW - Energy KW - Microscopy KW - Lasers KW - Wavelength KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680440446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lasers+in+Medical+Science&rft.atitle=Effect+of+therapeutic+femtosecond+laser+pulse+energy%2C+repetition+rate%2C+and+numerical+aperture+on+laser-induced+second+and+third+harmonic+generation+in+corneal+tissue&rft.au=Calhoun%2C+William+R%3BIlev%2C+Ilko+K&rft.aulast=Calhoun&rft.aufirst=William&rft.date=2015-05-01&rft.volume=30&rft.issue=4&rft.spage=1341&rft.isbn=&rft.btitle=&rft.title=Lasers+in+Medical+Science&rft.issn=02688921&rft_id=info:doi/10.1007%2Fs10103-015-1726-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 39 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Repetition; Data processing; Cornea; Energy; Microscopy; Lasers; Wavelength DO - http://dx.doi.org/10.1007/s10103-015-1726-5 ER - TY - JOUR T1 - Estimating the Benefits of Public Health Policies that Reduce Harmful Consumption AN - 1680436073; PQ0001425934 AB - For products such as tobacco and junk food, where policy interventions are often designed to decrease consumption, affected consumers gain utility from improvements in lifetime health and longevity but also lose utility associated with the activity of consuming the product. In the case of anti-smoking policies, even though published estimates of gross health and longevity benefits are up to 900 times higher than the net consumer benefits suggested by a more direct willingness-to-pay estimation approach, there is little recognition in the cost-benefit and cost-effectiveness literature that gross estimates will overstate intrapersonal welfare improvements when utility losses are not netted out. This paper presents a general framework for analyzing policies that are designed to reduce inefficiently high consumption and provides a rule of thumb for the relationship between net and gross consumer welfare effects: where there exists a plausible estimate of the tax that would allow consumers to fully internalize health costs, the ratio of the tax to the per-unit long-term cost can provide an upper bound on the ratio of net to gross benefits. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Health Economics AU - Ashley, Elizabeth M AU - Nardinelli, Clark AU - Lavaty, Rosemarie A AD - Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 617 EP - 624 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 5 SN - 1057-9230, 1057-9230 KW - Health & Safety Science Abstracts KW - Taxation KW - Willingness to pay KW - USA KW - Economics KW - Tobacco KW - Intervention KW - Longevity KW - Cost benefit analysis KW - Public health KW - H 9000:Consumer and Recreation Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680436073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Estimating+the+Benefits+of+Public+Health+Policies+that+Reduce+Harmful+Consumption&rft.au=Ashley%2C+Elizabeth+M%3BNardinelli%2C+Clark%3BLavaty%2C+Rosemarie+A&rft.aulast=Ashley&rft.aufirst=Elizabeth&rft.date=2015-05-01&rft.volume=24&rft.issue=5&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.3040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Willingness to pay; Taxation; Economics; Tobacco; Intervention; Cost benefit analysis; Longevity; Public health; USA DO - http://dx.doi.org/10.1002/hec.3040 ER - TY - JOUR T1 - Continued progress in developing the Pig-a gene mutation assay. AN - 1680178983; 25934984 AB - The Pig-a assay has shown promise as a regulatory assay for evaluating in vivo gene mutation. A recent International Workshop on Genotoxicity Testing workgroup discussed the state of the assay and identified several knowledge gaps in assay development. This Mutagenesis Special Topic includes a collection of reports that addresses some of these knowledge gaps, including identifying the mutations responsible for the Pig-a mutant phenotype, the effect of sex on the response, probing the robustness of the assay and expanding the number of agents tested in the assay, especially agents expected to yield negative responses. © The Author 2015. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. JF - Mutagenesis AU - Heflich, Robert H AU - Dobrovolsky, Vasily N AU - Dertinger, Stephen D AD - U.S. Food and Drug Administration/National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, Jefferson, AR 72079, USA robert.heflich@fda.hhs.gov. ; U.S. Food and Drug Administration/National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, Jefferson, AR 72079, USA. ; Litron Laboratories, Rochester, NY 14623, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 313 EP - 314 VL - 30 IS - 3 KW - GPI-Linked Proteins KW - 0 KW - Membrane Proteins KW - phosphatidylinositol glycan-class A protein KW - Index Medicus KW - Animals KW - GPI-Linked Proteins -- biosynthesis KW - Humans KW - Genes, Reporter KW - Mutation KW - Membrane Proteins -- genetics KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680178983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Continued+progress+in+developing+the+Pig-a+gene+mutation+assay.&rft.au=Heflich%2C+Robert+H%3BDobrovolsky%2C+Vasily+N%3BDertinger%2C+Stephen+D&rft.aulast=Heflich&rft.aufirst=Robert&rft.date=2015-05-01&rft.volume=30&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgeu082 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-16 N1 - Date created - 2015-05-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/geu082 ER - TY - GEN T1 - Alternatives to PFASs: perspectives on the science. AN - 1677887250; 25932670 JF - Environmental health perspectives AU - Birnbaum, Linda S AU - Grandjean, Philippe Y1 - 2015/05// PY - 2015 DA - May 2015 SP - A104 EP - A105 VL - 123 IS - 5 KW - Fluorocarbons KW - 0 KW - Surface-Active Agents KW - Index Medicus KW - Fluorocarbons -- chemistry KW - Animals KW - Environmental Health KW - Humans KW - Fluorocarbons -- toxicity KW - Surface-Active Agents -- chemistry KW - Surface-Active Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677887250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Environmental+health+perspectives&rft.atitle=Alternatives+to+PFASs%3A+perspectives+on+the+science.&rft.au=Birnbaum%2C+Linda+S%3BGrandjean%2C+Philippe&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2015-05-01&rft.volume=123&rft.issue=5&rft.spage=A104&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1509944 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-04 N1 - Date created - 2015-05-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2004 Jan;112(1):9-17 [14698924] Environ Sci Technol. 2010 Dec 15;44(24):9244-9 [21062050] Integr Environ Assess Manag. 2011 Oct;7(4):513-41 [21793199] Environ Health Perspect. 2013 Jan;121(1):A9 [23287533] Environ Int. 2013 Oct;60:242-8 [24660230] Environ Health Perspect. 2015 Jul;123(7):643-50 [25775505] Public Health Rep. 2014 Nov-Dec;129(6):482-5 [25364048] Sci Total Environ. 2015 Feb 1;505:981-91 [25461098] Environ Int. 2015 Feb;75:172-9 [25461427] Environ Health Perspect. 2015 May;123(5):A107-11 [25932614] Environ Health Perspect. 2015 May;123(5):A112-3 [25933200] Chemosphere. 2014 Nov;114:337-9 [24938172] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1509944 ER - TY - JOUR T1 - Characterisation of novel mutations involved in quinolone resistance in Escherichia coli isolated from imported shrimp. AN - 1675873336; 25631675 AB - Fifty-five nalidixic acid-resistant Escherichia coli strains were isolated from imported shrimp. Purified PCR amplicons of gyrA, gyrB, parC and parE from the template DNA of all isolates were sequenced and analysed for point mutations that confer resistance to nalidixic acid and ciprofloxacin. Point mutations in the quinolone resistance-determining regions (QRDRs) of GyrA at positions 68, 83 and 87 and in ParC at positions 80 and 84 as well as in the non-QRDR of GyrA at positions 112, 127, 128 and 154 along with point mutations in parE at position 476 conferred resistance to these antibiotics. Computational modelling and analysis of the different point mutations and their role in the enhanced resistance to these antibiotics indicated that only mutation at codons 83 (Ser→Ile) and 87 (Asp→Asn) played a vital role in increasing the minimum inhibitory concentration (MIC) to these drugs compared with other mutations. Ethidium bromide experiments indicated higher efflux pump activities in quinolone-resistant E. coli strains compared with their quinolone-sensitive counterparts. Class 1 integrons measuring 0.7-2.3kb were amplified and sequenced from the template DNA of the isolates. Sequence analysis of the 2.0kb and 1.7kb integrons indicated the presence of resistance determinants for trimethoprim (dfrA12 and dfrA17) and aminoglycosides (aadA2 and aadA5). These results indicate that use of nalidixic acid, ciprofloxacin and other antibiotics in shrimp aquaculture ponds may select E. coli resistant to these antibiotics and that imported shrimp is a reservoir of multiple antibiotic-resistant E. coli. Published by Elsevier B.V. JF - International journal of antimicrobial agents AU - Nawaz, Mohamed AU - Sung, Kidon AU - Kweon, Ohgew AU - Khan, Saeed AU - Nawaz, Samia AU - Steele, Roger AD - Division of Microbiology, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA. Electronic address: Mohamed.Nawaz@fda.hhs.gov. ; Division of Microbiology, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; Hendrix College, Conway, AR 72032, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 471 EP - 476 VL - 45 IS - 5 KW - Anti-Bacterial Agents KW - 0 KW - Escherichia coli Proteins KW - Quinolones KW - Nalidixic Acid KW - 3B91HWA56M KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Index Medicus KW - Escherichia coli KW - Quinolone resistance KW - Imported shrimp KW - Nalidixic Acid -- pharmacology KW - Models, Molecular KW - Seafood -- microbiology KW - Sequence Analysis, DNA KW - Biological Transport, Active KW - Selection, Genetic KW - Ciprofloxacin -- pharmacology KW - Escherichia coli Proteins -- chemistry KW - Polymerase Chain Reaction KW - Point Mutation KW - Microbial Sensitivity Tests KW - Escherichia coli Proteins -- genetics KW - Protein Conformation KW - Drug Resistance, Bacterial KW - Escherichia coli -- drug effects KW - Anti-Bacterial Agents -- pharmacology KW - Escherichia coli -- genetics KW - Mutation, Missense KW - Quinolones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675873336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+antimicrobial+agents&rft.atitle=Characterisation+of+novel+mutations+involved+in+quinolone+resistance+in+Escherichia+coli+isolated+from+imported+shrimp.&rft.au=Nawaz%2C+Mohamed%3BSung%2C+Kidon%3BKweon%2C+Ohgew%3BKhan%2C+Saeed%3BNawaz%2C+Samia%3BSteele%2C+Roger&rft.aulast=Nawaz&rft.aufirst=Mohamed&rft.date=2015-05-01&rft.volume=45&rft.issue=5&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=International+journal+of+antimicrobial+agents&rft.issn=1872-7913&rft_id=info:doi/10.1016%2Fj.ijantimicag.2014.11.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-08 N1 - Date created - 2015-04-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ijantimicag.2014.11.010 ER - TY - JOUR T1 - In vivo genotoxicity of estragole in male F344 rats. AN - 1675167953; 25361439 AB - Estragole, a naturally occurring constituent of various herbs and spices, is a rodent liver carcinogen which requires bio-activation. To further understand the mechanisms underlying its carcinogenicity, genotoxicity was assessed in F344 rats using the comet, micronucleus (MN), and DNA adduct assays together with histopathological analysis. Oxidative damage was measured using human 8-oxoguanine-DNA-N-glycosylase (hOGG1) and EndonucleaseIII (EndoIII)-modified comet assays. Results with estragole were compared with the structurally related genotoxic carcinogen, safrole. Groups of seven-week-old male F344 rats received corn oil or corn oil containing 300, 600, or 1,000 mg/kg bw estragole and 125, 250, or 450 mg/kg bw safrole by gavage at 0, 24, and 45 hr and terminated at 48 hr. Estragole-induced dose-dependent increases in DNA damage following EndoIII or hOGG1 digestion and without enzyme treatment in liver, the cancer target organ. No DNA damage was detected in stomach, the non-target tissue for cancer. No elevation of MN was observed in reticulocytes sampled from peripheral blood. Comet assays, both without digestion or with either EndoIII or hOGG1 digestion, also detected DNA damage in the liver of safrole-dosed rats. No DNA damage was detected in stomach, nor was MN elevated in peripheral blood following dosing with safrole suggesting that, as far both safrole and estragole, oxidative damage may contribute to genotoxicity. Taken together, these results implicate multiple mechanisms of estragole genotoxicity. DNA damage arises from chemical-specific interaction and is also mediated by oxidative species. © 2014 Crown copyright. JF - Environmental and molecular mutagenesis AU - Ding, Wei AU - Levy, Dan D AU - Bishop, Michelle E AU - Pearce, Mason G AU - Davis, Kelly J AU - Jeffrey, Alan M AU - Duan, Jian-Dong AU - Williams, Gary M AU - White, Gene A AU - Lyn-Cook, Lascelles E AU - Manjanatha, Mugimane G AD - Division of Genetic and Molecular Toxicology, US FDA/National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 356 EP - 365 VL - 56 IS - 4 KW - Anisoles KW - 0 KW - DNA Adducts KW - estragole KW - 9NIW07V3ET KW - DNA Glycosylases KW - EC 3.2.2.- KW - oxoguanine glycosylase 1, human KW - Safrole KW - RSB34337V9 KW - Index Medicus KW - cell proliferation KW - inflammation KW - In vivo comet assay KW - oxidative DNA damage KW - direct DNA damage KW - Animals KW - Liver -- pathology KW - Kidney -- pathology KW - Kidney -- drug effects KW - Comet Assay -- methods KW - Stomach -- drug effects KW - Safrole -- toxicity KW - DNA Damage -- drug effects KW - Rats, Inbred F344 KW - Micronucleus Tests KW - Liver -- drug effects KW - DNA Glycosylases -- metabolism KW - Male KW - Mutagenicity Tests -- methods KW - Anisoles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675167953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=In+vivo+genotoxicity+of+estragole+in+male+F344+rats.&rft.au=Ding%2C+Wei%3BLevy%2C+Dan+D%3BBishop%2C+Michelle+E%3BPearce%2C+Mason+G%3BDavis%2C+Kelly+J%3BJeffrey%2C+Alan+M%3BDuan%2C+Jian-Dong%3BWilliams%2C+Gary+M%3BWhite%2C+Gene+A%3BLyn-Cook%2C+Lascelles+E%3BManjanatha%2C+Mugimane+G&rft.aulast=Ding&rft.aufirst=Wei&rft.date=2015-05-01&rft.volume=56&rft.issue=4&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.21918 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-30 N1 - Date created - 2015-04-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/em.21918 ER - TY - JOUR T1 - Does household use of biomass fuel cause lung cancer? A systematic review and evaluation of the evidence for the GBD 2010 study. AN - 1673372021; 25758120 AB - Around 2.4 billion people use traditional biomass fuels for household cooking or heating. In 2006, the International Agency for Research on Cancer (IARC) concluded emissions from household coal combustion are a Group 1 carcinogen, while those from biomass were categorised as 2A due to epidemiologic limitations. This review updates the epidemiologic evidence and provides risk estimates for the 2010 Global Burden of Disease study. Searches were conducted of 10 databases to July 2012 for studies of clinically diagnosed or pathologically confirmed lung cancer associated with household biomass use for cooking and/or heating. Fourteen eligible studies of biomass cooking or heating were identified: 13 had independent estimates (12 cooking only), all were case-control designs and provided 8221 cases and 11 342 controls. The ORs for lung cancer risk with biomass for cooking and/or heating were OR 1.17 (95% CI 1.01 to 1.37) overall, and 1.15 (95% CI 0.97 to 1.37) for cooking only. Publication bias was not detected, but more than half the studies did not explicitly describe a clean reference category. Sensitivity analyses restricted to studies with adequate adjustment and a clean reference category found ORs of 1.21 (95% CI 1.05 to 1.39) for men (two reports, compiling five studies) and 1.95 (95% CI 1.16 to 3.27) for women (five reports, compiling eight studies). Exposure-response evidence was seen for men, and higher risk for women in developing compared with developed countries, consistent with higher exposures in the former. There is now stronger evidence for biomass fuel use causing lung cancer, but future studies need better exposure assessment to strengthen exposure-response evidence. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Thorax AU - Bruce, Nigel AU - Dherani, Mukesh AU - Liu, Rui AU - Hosgood, H Dean AU - Sapkota, Amir AU - Smith, Kirk R AU - Straif, Kurt AU - Lan, Qing AU - Pope, Daniel AD - Department of Public Health and Policy, University of Liverpool, Liverpool, UK. ; Environmental Health Sciences, School of Public Health, University of California Berkeley, California, USA. ; Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Division of Epidemiology, Albert Einstein College of Medicine, Bronx, New York, USA. ; Maryland Institute for Applied Environmental Health, University of Maryland, School of Public Health, College Park, Maryland, USA. ; International Agency for Research on Cancer, Lyon, France. ; Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 433 EP - 441 VL - 70 IS - 5 KW - Index Medicus KW - Clinical Epidemiology KW - Lung Cancer KW - Air Pollution, Indoor -- adverse effects KW - Humans KW - Wood KW - Male KW - Female KW - Lung Neoplasms -- etiology KW - Heating KW - Cooking KW - Biomass KW - Energy-Generating Resources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673372021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thorax&rft.atitle=Does+household+use+of+biomass+fuel+cause+lung+cancer%3F+A+systematic+review+and+evaluation+of+the+evidence+for+the+GBD+2010+study.&rft.au=Bruce%2C+Nigel%3BDherani%2C+Mukesh%3BLiu%2C+Rui%3BHosgood%2C+H+Dean%3BSapkota%2C+Amir%3BSmith%2C+Kirk+R%3BStraif%2C+Kurt%3BLan%2C+Qing%3BPope%2C+Daniel&rft.aulast=Bruce&rft.aufirst=Nigel&rft.date=2015-05-01&rft.volume=70&rft.issue=5&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=1468-3296&rft_id=info:doi/10.1136%2Fthoraxjnl-2014-206625 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-22 N1 - Date created - 2015-04-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/thoraxjnl-2014-206625 ER - TY - JOUR T1 - 7-glutathione pyrrole adduct: a potential DNA reactive metabolite of pyrrolizidine alkaloids. AN - 1674689702; 25768656 AB - Pyrrolizidine alkaloid (PA)-containing plants are the most common poisonous plants affecting livestock, wildlife, and humans. PAs require metabolic activation to form pyrrolic metabolites to exert cytotoxicity and tumorigenicity. We previously determined that metabolism of tumorigenic PAs produced four DNA adducts, designated as DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4, that are responsible for liver tumor initiation. 7-Glutathione-(±)-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine (7-GS-DHP), formed in vivo and in vitro, and 7,9-di-GS-DHP, formed in vitro, are both considered detoxified metabolites. However, in this study we determined that incubation of 7-GS-DHP with 2'-deoxyguanosine (dG) and 2'-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. Furthermore, reaction of 7-GS-DHP with calf thymus DNA in aqueous solution at 37 °C for 4, 8, 16, 24, 48, or 72 h, followed by enzymatic hydrolysis yielded DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts. Under our current experimental conditions, DHP-dA-3 and DHP-dA-4 adducts were formed in a trace amount from the reaction of 7,9-di-GS-DHP with dA. No DHP-dG-3 or DHP-dG-4 adducts were detected from the reaction of 7,9-di-GS-DHP with dG. This study represents the first report that the 7-GS-DHP adduct can be a potential reactive metabolite of PAs leading to DNA adduct formation. JF - Chemical research in toxicology AU - Xia, Qingsu AU - Ma, Liang AU - He, Xiaobo AU - Cai, Lining AU - Fu, Peter P AD - †National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, United States. ; ‡Biotranex LLC, Monmouth Junction, New Jersey 08852, United States. Y1 - 2015/04/20/ PY - 2015 DA - 2015 Apr 20 SP - 615 EP - 620 VL - 28 IS - 4 KW - DNA Adducts KW - 0 KW - Pyrroles KW - Pyrrolizidine Alkaloids KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Cattle KW - Chromatography, High Pressure Liquid KW - DNA Adducts -- chemistry KW - Glutathione -- chemistry KW - Pyrroles -- chemistry KW - Pyrrolizidine Alkaloids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1674689702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=7-glutathione+pyrrole+adduct%3A+a+potential+DNA+reactive+metabolite+of+pyrrolizidine+alkaloids.&rft.au=Xia%2C+Qingsu%3BMa%2C+Liang%3BHe%2C+Xiaobo%3BCai%2C+Lining%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2015-04-20&rft.volume=28&rft.issue=4&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx500417q LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-04-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/tx500417q ER - TY - CPAPER T1 - Human biospecimens for in vitro diagnostics: Regulatory considerations T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669824171; 6339255 JF - 2015 American Association for Cancer Research Annual Meeting AU - Hu, Yun-Fu Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Epidemiology KW - Oncology KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669824171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Human+biospecimens+for+in+vitro+diagnostics%3A+Regulatory+considerations&rft.au=Hu%2C+Yun-Fu&rft.aulast=Hu&rft.aufirst=Yun-Fu&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Next Generation Sequencing Tests - Optimizing Regulatory Oversight, from Cancer Panels to Whole Genome T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669823826; 6339646 JF - 2015 American Association for Cancer Research Annual Meeting AU - Tezak, Zivana Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Genomes KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Next+Generation+Sequencing+Tests+-+Optimizing+Regulatory+Oversight%2C+from+Cancer+Panels+to+Whole+Genome&rft.au=Tezak%2C+Zivana&rft.aulast=Tezak&rft.aufirst=Zivana&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Mechanism of the transferrin receptor 1 dysregulation in hepatocarcinogenesis T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669823618; 6339530 JF - 2015 American Association for Cancer Research Annual Meeting AU - Kindrat, Iryna Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Transferrin receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Mechanism+of+the+transferrin+receptor+1+dysregulation+in+hepatocarcinogenesis&rft.au=Kindrat%2C+Iryna&rft.aulast=Kindrat&rft.aufirst=Iryna&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Careers in Government T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669823561; 6339399 JF - 2015 American Association for Cancer Research Annual Meeting AU - Lyn-Cook, Beverly Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Careers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Careers+in+Government&rft.au=Lyn-Cook%2C+Beverly&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Careers in Cancer: Government T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669823150; 6340078 JF - 2015 American Association for Cancer Research Annual Meeting AU - Lyn-Cook, Beverly Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Careers KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Careers+in+Cancer%3A+Government&rft.au=Lyn-Cook%2C+Beverly&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Tuberculosis Control in South African Gold Mines: Mathematical Modeling of a Trial of Community-Wide Isoniazid Preventive Therapy AN - 1709174263; PQ0001732834 AB - A recent major cluster randomized trial of screening, active disease treatment, and mass isoniazid preventive therapy for 9 months during 2006-2011 among South African gold miners showed reduced individual-level tuberculosis incidence but no detectable population-level impact. We fitted a dynamic mathematical model to trial data and explored 1) factors contributing to the lack of population-level impact, 2) the best-achievable impact if all implementation characteristics were increased to the highest level achieved during the trial ("optimized intervention"), and 3) how tuberculosis might be better controlled with additional interventions (improving diagnostics, reducing treatment delay, providing isoniazid preventive therapy continuously to human immunodeficiency virus-positive people, or scaling up antiretroviral treatment coverage) individually and in combination. We found the following: 1) The model suggests that a small proportion of latent infections among human immunodeficiency virus-positive people were cured, which could have been a key factor explaining the lack of detectable population-level impact. 2) The optimized implementation increased impact by only 10%. 3) Implementing additional interventions individually and in combination led to up to 30% and 75% reductions, respectively, in tuberculosis incidence after 10 years. Tuberculosis control requires a combination prevention approach, including health systems strengthening to minimize treatment delay, improving diagnostics, increased antiretroviral treatment coverage, and effective preventive treatment regimens. JF - American Journal of Epidemiology AU - Vynnycky, Emilia AU - Sumner, Tom AU - Fielding, Katherine L AU - Lewis, James J AU - Cox, Andrew P AU - Hayes, Richard J AU - Corbett, Elizabeth L AU - Churchyard, Gavin J AU - Grant, Alison D AU - White, Richard G AD - Correspondence to Dr. Emilia Vynnycky, Statistics, Modelling and Economics Department, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United Kingdom,; emilia.vynnycky@lshtm.ac.uk] emilia.vynnycky@phe.gov.uk Y1 - 2015/04/15/ PY - 2015 DA - 2015 Apr 15 SP - 619 EP - 632 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 181 IS - 8 SN - 0002-9262, 0002-9262 KW - Microbiology Abstracts B: Bacteriology KW - mass community-wide isoniazid preventive therapy KW - mathematical model KW - tuberculosis KW - Latent infection KW - Mathematical models KW - Data processing KW - Antiviral agents KW - Mycobacterium KW - Immunodeficiency KW - Gold KW - Tuberculosis KW - Mines KW - Scaling KW - Isoniazid KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709174263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Tuberculosis+Control+in+South+African+Gold+Mines%3A+Mathematical+Modeling+of+a+Trial+of+Community-Wide+Isoniazid+Preventive+Therapy&rft.au=Vynnycky%2C+Emilia%3BSumner%2C+Tom%3BFielding%2C+Katherine+L%3BLewis%2C+James+J%3BCox%2C+Andrew+P%3BHayes%2C+Richard+J%3BCorbett%2C+Elizabeth+L%3BChurchyard%2C+Gavin+J%3BGrant%2C+Alison+D%3BWhite%2C+Richard+G&rft.aulast=Vynnycky&rft.aufirst=Emilia&rft.date=2015-04-15&rft.volume=181&rft.issue=8&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwu320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Latent infection; Data processing; Mathematical models; Antiviral agents; Immunodeficiency; Gold; Tuberculosis; Mines; Scaling; Isoniazid; Mycobacterium DO - http://dx.doi.org/10.1093/aje/kwu320 ER - TY - JOUR T1 - Non-fatal work-related traumatic brain injuries treated in US hospital emergency departments, 1998-2007 AN - 1808706884; PQ0003427539 AB - PurposeLittle is known about work-related traumatic brain injuries (WRTBI). This study describes non-fatal WRTBIs treated in US emergency departments (ED) from 1998 through 2007.MethodsNon-fatal WRTBIs were identified from the National Electronic Injury Surveillance System occupational supplement (NEISS-Work) using the diagnoses of concussion, internal organ injury to the head and skull fracture. WRTBI rates and rate ratios were calculated, and the trend in rates was assessed.ResultsAn estimated 586600 (95% CI= plus or minus 150000) WRTBIs were reported during the 10-year period at a rate of 4.3 (CI= plus or minus 1.1) per 10000 full-time equivalent (FTE) workers (1 FTE=2000h per year). From 1998 through 2007, the rate of WRTBIs increased at an average of 0.21 per 10000 FTE per year (p<0.0001) and the rate of fall-related WRTBIs increased at an average of 0.10 per 10000 FTE (p<0.0001). During the same period, the annual rate of WRTBIs resulting in hospitalisation increased 0.04 per 10000 FTE (p<0.0001). Ten percent of WRTBIs were hospitalised, compared with hospitalisation of 2% all NEISS-Work injuries. Also, workers with highest fall-related TBI rates per 10000 FTE were the youngest (2.4; CI= plus or minus 1.4) and oldest (55 and older) workers (1.9; CI= plus or minus 0.8).ConclusionsNon-fatal WRTBIs are one of the most serious workplace injuries among ED-treated work-related injuries. Non-fatal WRTBIs are much more likely to result in hospitalisation compared with other types of injuries. The upward trend of WRTBI rates from 1998 through 2007 underscore the need for more directed effective prevention methods to reduce WRTBI injuries. JF - Injury Prevention AU - Konda, Srinivas AU - Reichard, Audrey AU - Tiesman, Hope M AU - Hendricks, Scott AD - Division of Safety Research, Analysis and Field Evaluations Branch, National Institute for Occupational Safety and Health, , Morgantown, West Virginia, USA Y1 - 2015/04/12/ PY - 2015 DA - 2015 Apr 12 SP - 115 EP - 120 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 21 IS - 2 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - Prevention KW - Injuries KW - Head injuries KW - Brain KW - Organs KW - Emergency medical services KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808706884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Non-fatal+work-related+traumatic+brain+injuries+treated+in+US+hospital+emergency+departments%2C+1998-2007&rft.au=Konda%2C+Srinivas%3BReichard%2C+Audrey%3BTiesman%2C+Hope+M%3BHendricks%2C+Scott&rft.aulast=Konda&rft.aufirst=Srinivas&rft.date=2015-04-12&rft.volume=21&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/10.1136%2Finjuryprev-2014-041323 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Prevention; Injuries; Head injuries; Brain; Organs; Hospitals; Emergency medical services DO - http://dx.doi.org/10.1136/injuryprev-2014-041323 ER - TY - RPRT T1 - NATIONAL INSTITUTES OF HEALTH BETHESDA CHILLED WATER SYSTEM IMPROVEMENTS, MONTGOMERY COUNTY, BETHESEDA, MARYLAND. AN - 16377952; 16466 AB - PURPOSE: The National Institutes of Health (NIH) is contemplating implementation of chilled water system improvements at the NIH Bethesda Campus. The need for the chilled water system improvements is to prevent a disruption in the chilled water supply which would result in severe consequences on patient care, animal welfare, and biomedical research. Improvements are needed to address real deficiencies within the campus water systems. Three alternatives were considered in detail in the Draft Environmental Impact Statement. The Proposed Action would install a Thermal Energy Storage System and an Industrial Water Storage System to provide sufficient storage capacity to meet two days of chilled water demand and two days of industrial water demand should an outside disturbance interrupt the water supply. The Alternative Action would install a Thermal Energy Storage System and a Potable Water Storage System to provide sufficient storage capacity to meet two days of chilled water demand and two days of potable water demand. The No-Action Alternative would continue current NIH operations and would not implement chilled water system improvements. JF - EPA number: 150089, Draft EIS, April 3, 2015 Y1 - 2015/04/03/ PY - 2015 DA - 2015 Apr 03 KW - Water KW - Water Storage KW - Water Supply KW - Industrial Water KW - Water Resources KW - Wetlands KW - Floodplains KW - Traffic Analyses KW - Noise KW - Air Quality KW - Vegetation KW - Wildlife Habitat KW - Soils KW - Archaeological Sites KW - Socioeconomic Assessments KW - Emissions KW - Historic Sites KW - Waste Management KW - Maryland KW - Clean Air Act Amendments of 1990, Emission Standards KW - Resources Conservation and Recovery Act, Compliance KW - National Historic Preservation Act of 1966, Historic Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16377952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2015-04-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CHILLED+WATER+SYSTEM+IMPROVEMENTS%2C+MONTGOMERY+COUNTY%2C+BETHESEDA%2C+MARYLAND.&rft.title=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CHILLED+WATER+SYSTEM+IMPROVEMENTS%2C+MONTGOMERY+COUNTY%2C+BETHESEDA%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland N1 - Date revised - 2016-07-07 N1 - SuppNotes - Draft. Preparation date: April 3, 2015 N1 - Last updated - 2016-07-08 ER - TY - JOUR T1 - Binge drinking and the risk of suicidal thoughts, plans, and attempts AN - 1837328674; PQ0001250489 AB - Background: Major depression is one of the strongest known risk factors for suicide. However, of the estimated 8.5 million adults with serious thoughts of suicide in the past year, only half had a major depressive episode (MDE). identifying risk factors for suicide in the absence of depression may provide additional targets for prevention and intervention. This study uses nationally representative data to evaluate the association of binge drinking with suicidal thoughts, plans, and attempts in adults with and without MDE. Methods: Combined 2008-2012 National Survey on Drug Use and Health data were analyzed. Sex-stratified prevalence estimates of past year suicide indicators were generated by past month binge drinking and past year MDE status. Logistic regression was used to evaluate the association of binge drinking with suicide indicators by sex with and without MDE. Results: Unadjusted prevalence estimates for suicide indicators in males and females were higher among binge drinkers than among nonbinge drinkers, regardless of MDE status. Regression analyses indicated that binge drinking was associated with suicidal thoughts (adjusted odds ratio [aOR] = 1.51, 95% confidence interval [CI] = 1.28-1.79), plans (aOR = 1.75, CI = 1.23-2.48), and attempts (aOR = 2.57, CI = 1.74-3.79) in females without MDE and with suicidal thoughts in males without MDE (aOR = 1.25, CI = 1.04-1.49). Among males and females with MDE, binge drinking was not associated with any of the suicide indicators (p > .05). Conclusions: Binge drinking in females without MDE may be an indicator for identifying at risk individuals for targeting suicide prevention activities. JF - Addictive Behaviors AU - Glasheen, Cristie AU - Pemberton, Michael R AU - Lipari, Rachel AU - Copello, Elizabeth A AU - Mattson, Margaret E AD - RTI International (a trade name of Research Triangle Institute International), 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC27709, United States, Margaret.Mattson@samhsa.hhs.gov Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 42 EP - 49 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 43 SN - 0306-4603, 0306-4603 KW - Toxicology Abstracts KW - Alcohol drinking KW - Binge drinking KW - Suicide KW - Sex KW - Depression KW - Drinking KW - Data processing KW - Risk factors KW - Regression analysis KW - Drugs KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837328674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Binge+drinking+and+the+risk+of+suicidal+thoughts%2C+plans%2C+and+attempts&rft.au=Glasheen%2C+Cristie%3BPemberton%2C+Michael+R%3BLipari%2C+Rachel%3BCopello%2C+Elizabeth+A%3BMattson%2C+Margaret+E&rft.aulast=Glasheen&rft.aufirst=Cristie&rft.date=2015-04-01&rft.volume=43&rft.issue=&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2014.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Drinking; Depression; Data processing; Risk factors; Regression analysis; Suicide; Drugs; Sex DO - http://dx.doi.org/10.1016/j.addbeh.2014.12.005 ER - TY - JOUR T1 - 0058Associations between socioeconomic status, rurality and motor vehicle traffic crash injury severity and treatment outcomes: findings from the nebraska trauma registry AN - 1808716028; PQ0003431131 AB - Statement of purposeBased on geocoded data from the Nebraska's trauma registry, the current study examines how socioeconomic status and rurality are associated with MVC injury severity and treatment outcomes.Methods/ApproachData from 2007-2012 was taken from Nebraska's Trauma Registry. Injuries caused by MVC were identified using ICD-9 External Cause of Injury Codes. 13,693 cases in the registry met criteria for this study.Cases were geocoded to residential addresses. Poverty status was determined by census tract, and rurality by county. Descriptive and multivariate analyses were used to determine associations between outcome variables, and socioeconomic status (neighbourhood poverty levels) and rurality. Two outcome variables, hospital length of stay and discharge to rehabilitative or homecare services, were considered.ResultsPersons from low-income neighbourhoods had a greater rate of inpatient treatment than persons from wealthier neighbourhoods. In particular, single-system or minor injuries (ISS <15) from lower income neighbourhoods were comparatively more likely to be admitted. Persons under 65 years old from low-income neighbourhoods had a significantly longer mean length of stay in the hospital for minor injuries. Persons from rural areas were less likely to be discharged to further services, and moderately more likely to have longer lengths of stay.ConclusionsPersons from low-income neighbourhoods were more likely to be admitted for minor injuries, to remain longer in the hospital and to be discharged without further services. This suggests that this group may lack access to outpatient care to treat minor injuries, or to continue treatment once discharged. The latter may encourage longer stays in hospital to ensure treatment compliance. Lack of access was also apparent for rural patients, who had longer lengths of stay and fewer discharges to further services than their urban counterparts.Significance and contribution to the fieldPrevious studies examining individual and neighbourhood risk factors of Motor Vehicle Traffic Crashes (MVC) injuries often use data sources where treatment and treatment outcomes were not often considered or reliable. Trauma Registry data provides rich and reliable patient information. JF - Injury Prevention AU - Cooper, Rachel AU - Qu, Ming AU - Lin, Ge AD - Nebraska Department of Health and Human Services, Lincoln, NE, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - A15 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 21 IS - Suppl 1 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - Injuries KW - Motor vehicles KW - Compliance KW - Socioeconomics KW - Traffic KW - Income KW - Prevention KW - Poverty KW - Risk factors KW - USA, Nebraska KW - Census KW - Rural areas KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808716028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=0058Associations+between+socioeconomic+status%2C+rurality+and+motor+vehicle+traffic+crash+injury+severity+and+treatment+outcomes%3A+findings+from+the+nebraska+trauma+registry&rft.au=Cooper%2C+Rachel%3BQu%2C+Ming%3BLin%2C+Ge&rft.aulast=Cooper&rft.aufirst=Rachel&rft.date=2015-04-01&rft.volume=21&rft.issue=Suppl+1&rft.spage=A15&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/10.1136%2Finjuryprev-2015-041602.37 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Prevention; Injuries; Risk factors; Poverty; Motor vehicles; Compliance; Socioeconomics; Census; Income; Rural areas; Traffic; USA, Nebraska DO - http://dx.doi.org/10.1136/injuryprev-2015-041602.37 ER - TY - JOUR T1 - 50Assessing the impact of niosh occupational motor vehicle safety research AN - 1808647116; PQ0003435172 AB - The ultimate purpose of violence and injury research is to make positive impacts on the public's safety. Documenting these impacts is challenging, especially since research is just one of many inputs that influence policy, the environment, and behaviour. Nonetheless, research agencies and researchers are increasingly being called upon to demonstrate the impact of their work, going beyond traditional metrics such as numbers of journal article citations. The Centres for Disease Control and Prevention (CDC) recently developed a framework for documenting science impacts, adapted from the Institute of Medicine Degrees of Impact framework. The CDC Science Impact Framework uses a combination of narrative, quantitative, and qualitative Methods to document and trace linkages between science and the events and actions that ultimately lead to public health impacts. Starting with a significant output (such as a seminal paper or technological innovation), the framework is used either prospectively or retrospectively to document and demonstrate linkages across five levels of influence: disseminating science, creating awareness, catalysing action, effecting change, and shaping the future. This presentation will illustrate how the CDC Science Impact Framework was applied to the CDC's National Institute for Occupational Safety and Health (NIOSH) research program on occupational motor vehicle safety. Motor vehicles are a leading cause of death and injury at work, and the occupational setting provides unique opportunities for intervention, including influencing employer policies and practices, guidance and materials used by unions and occupational safety professionals, and the design and use of engineering controls on unique work vehicles (e.g. tractor-trailers, fire trucks, and ambulances). This presentation will provide examples of how impacts were traced from key NIOSH documents containing evidence-based policy recommendations and other NIOSH research findings. It will also include lessons learned from this exercise in terms of maximising future impact.DisclaimerThe findings and conclusions in this abstract are those of the authors and do not necessarily represent the views of NIOSH. JF - Injury Prevention AU - Castillo, Dawn AU - Novicki, Emily AU - Pratt, Stephanie AD - National Institute for Occupational Safety and Health, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - A18 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 21 IS - Suppl 2 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - Mortality KW - Fires KW - Injuries KW - Motor vehicles KW - Occupational safety KW - Safety KW - Disease control KW - Intervention KW - Public health KW - Prevention KW - Safety engineering KW - Trucks KW - Research programs KW - Agricultural equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808647116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=50Assessing+the+impact+of+niosh+occupational+motor+vehicle+safety+research&rft.au=Castillo%2C+Dawn%3BNovicki%2C+Emily%3BPratt%2C+Stephanie&rft.aulast=Castillo&rft.aufirst=Dawn&rft.date=2015-04-01&rft.volume=21&rft.issue=Suppl+2&rft.spage=A18&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/10.1136%2Finjuryprev-2015-041654.50 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Fires; Mortality; Injuries; Motor vehicles; Safety; Occupational safety; Disease control; Intervention; Public health; Prevention; Safety engineering; Trucks; Research programs; Agricultural equipment DO - http://dx.doi.org/10.1136/injuryprev-2015-041654.50 ER - TY - JOUR T1 - 0023Using the new title v MCH national performance measure 7 to reduce injury-related hospitalizations among children and adolescents ages 0-19 AN - 1808623420; PQ0003431138 AB - Statement of purposeEvery year, one in nine young people is injured seriously enough to require medical attention, and nearly 320,000 injury-related hospitalizations occur. Injuries are a leading cause of medical spending for children and adolescents, a burden estimated at $4 billion in annual healthcare costs for hospitalizations alone. By focusing on the reduction of injury-related hospitalizations, public health professionals can significantly reduce the toll of injuries in the U.S.Methods/ApproachThe Health Resources and Services Administration's Maternal and Child Health Bureau has proposed the reduction of injury-related hospitalizations among infants, children, and adolescents ages 0 through 19 as one of 15 possible National Performance Measures (NPMs) for inclusion in the Title V Maternal and Child Health Services Block Grant Program. This presentation will describe this new NPM and explain the opportunity that it provides for improving the health and safety of infants, children, and adolescents.ResultsPresenters will explain the burden of injury-related hospitalizations in the U.S.; describe the new Title V Maternal and Child Health (MCH) Performance Measure framework and how it is related to the 5-year Needs Assessments that state MCH programs are currently conducting; provide an overview of ways to get involved in the Needs Assessment process and the selection of injury-related NPMs; and share Children's Safety Network (CSN) resources on effective strategies for reducing injury-related hospitalizations.ConclusionsParticipants will be equipped to use the new injury hospitalisation NPM to address a range of important injury issues, including falls, motor vehicle crashes, prescription drug overdoses, suicide, homicide, drowning, and sudden and unexpected infant death. They will also have an opportunity for interactive discussion about ways for state injury prevention programs to collaborate with state MCH programs on the selection of evidence-based strategies to address the injury hospitalisation NPM.Significance and contribution to the fieldThe new Title V MCH Performance Measure framework provides injury prevention professionals with new opportunities to leverage existing partnerships and build new alliances to advance effective policies and practices for reducing injury-related hospitalizations. This presentation will enable participants to capitalise on those opportunities and make injury prevention a state and national priority. JF - Injury Prevention AU - Reiney, Erin AU - Allison, Jennifer AU - Hunt, Rebekah AD - Maternal and Child Health Bureau, Rockville, MD, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - A25 EP - A26 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 21 IS - Suppl 1 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - Mortality KW - Age KW - Drowning KW - Injuries KW - Safety KW - Suicide KW - Children KW - Prevention KW - Homicide KW - Health care KW - Priorities KW - Drugs KW - Adolescents KW - Infants KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808623420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=0023Using+the+new+title+v+MCH+national+performance+measure+7+to+reduce+injury-related+hospitalizations+among+children+and+adolescents+ages+0-19&rft.au=Reiney%2C+Erin%3BAllison%2C+Jennifer%3BHunt%2C+Rebekah&rft.aulast=Reiney&rft.aufirst=Erin&rft.date=2015-04-01&rft.volume=21&rft.issue=Suppl+1&rft.spage=A25&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/10.1136%2Finjuryprev-2015-041602.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Injuries; Drowning; Safety; Suicide; Children; Homicide; Prevention; Health care; Priorities; Drugs; Adolescents; Infants DO - http://dx.doi.org/10.1136/injuryprev-2015-041602.63 ER - TY - JOUR T1 - The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB AN - 1785235814; PQ0002900869 AB - In the event of a mass casualty radiation incident, the gamma-H2AX foci assay could be a useful tool to estimate radiation doses received by individuals. The rapid processing time of blood samples of just a few hours and the potential for batch processing, enabling high throughput, make the assay ideal for early triage categorisation to separate the 'worried well' from the low and critically exposed by quantifying radiation-induced foci in peripheral blood lymphocytes. Within the RENEB framework, 8 European laboratories have taken part in the first European gamma-H2AX biodosimetry exercise, which consisted of a telescoring comparison of 200 circulated foci images taken from 8 samples, and a comparison of 10 fresh blood lymphocyte samples that were shipped overnight to participating labs 4 or 24 h post-exposure. Despite large variations between laboratories in the dose-response relationship for foci induction, the obtained results indicate that the network should be able to use the gamma-H2AX assay for rapidly identifying the most severely exposed individuals within a cohort who could then be prioritised for accurate chromosome dosimetry. JF - Radiation Protection Dosimetry AU - Barnard, S AU - Ainsbury, E A AU - Al-hafidh, J AU - Hadjidekova, V AU - Hristova, R AU - Lindholm, C AU - Gil, O Monteiro AU - Moquet, J AU - Moreno, M AU - Rossler, U AU - Thierens, H AU - Vandevoorde, C AU - Vral, A AU - Wojewodzka, M AU - Rothkamm, K AD - Public Health England, Centre for Radiation Chemical and Environmental Hazards, Chilton, UK, stephen.barnard@phe.gov.uk Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 265 EP - 270 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 164 IS - 3 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Chromosomes KW - Radiation KW - Dose-response effects KW - Dosimetry KW - Lymphocytes KW - ENA 18:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785235814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=The+first+gamma-H2AX+biodosimetry+intercomparison+exercise+of+the+developing+European+biodosimetry+network+RENEB&rft.au=Barnard%2C+S%3BAinsbury%2C+E+A%3BAl-hafidh%2C+J%3BHadjidekova%2C+V%3BHristova%2C+R%3BLindholm%2C+C%3BGil%2C+O+Monteiro%3BMoquet%2C+J%3BMoreno%2C+M%3BRossler%2C+U%3BThierens%2C+H%3BVandevoorde%2C+C%3BVral%2C+A%3BWojewodzka%2C+M%3BRothkamm%2C+K&rft.aulast=Barnard&rft.aufirst=S&rft.date=2015-04-01&rft.volume=164&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncu259 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - Chromosomes; Radiation; Dose-response effects; Dosimetry; Lymphocytes DO - http://dx.doi.org/10.1093/rpd/ncu259 ER - TY - JOUR T1 - Development of a retrospective/fortuitous accident dosimetry service based on OSL of mobile phones AN - 1785224709; PQ0002900853 AB - Work is presented on the development of a retrospective/fortuitous accident dosimetry service using optically stimulated luminescence of resistors found in mobile phones to determine the doses of radiation to members of the public following a radiological accident or terrorist incident. The system is described and discussed in terms of its likely accuracy in a real incident. JF - Radiation Protection Dosimetry AU - Smith, R W AU - Eakins, J S AU - Hager, L G AU - Rothkamm, K AU - Tanner, R J AD - Public Health England (PHE), Centre for Radiation, Chemical and Environmental Hazards (CRCE), Chilton, Didcot, Oxon OX11 0RQ, UK, rick.tanner@phe.gov.uk Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 89 EP - 92 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 164 IS - 1-2 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Accidents KW - Terrorism KW - Radiation KW - Dosimetry KW - Occupational safety KW - Cellular telephones KW - Luminescence KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785224709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Development+of+a+retrospective%2Ffortuitous+accident+dosimetry+service+based+on+OSL+of+mobile+phones&rft.au=Smith%2C+R+W%3BEakins%2C+J+S%3BHager%2C+L+G%3BRothkamm%2C+K%3BTanner%2C+R+J&rft.aulast=Smith&rft.aufirst=R&rft.date=2015-04-01&rft.volume=164&rft.issue=1-2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncu370 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Accidents; Terrorism; Radiation; Occupational safety; Dosimetry; Cellular telephones; Luminescence DO - http://dx.doi.org/10.1093/rpd/ncu370 ER - TY - JOUR T1 - A single chimpanzee-human neutralizing monoclonal antibody provides post-exposure protection against type 1 and type 2 polioviruses AN - 1732815754; PQ0002215087 AB - Background Development of anti-poliovirus therapies to complement vaccination is an urgent priority. A number of antiviral drugs are in development. Recently we have developed human monoclonal antibodies that could be used for treatment of chronically infected individuals and emergency response to potential reappearance of polioviruses after eradication. Objective The aim of this study was to characterize neutralizing activity of anti-poliovirus monoclonal antibody A12 against wild type, vaccine-derived, and drug-resistant poliovirus strains, evaluate in vivo pre- and post-exposure protective properties of the antibody against polioviruses of serotypes 1 and 2, and to determine whether it interferes with response to immunization with poliovirus vaccine. Study design Immunogenicity studies were performed in CD1 mice. Poliovirus neutralizing titers were determined in poliovirus microneutralization assay. Poliovirus immunization-challenge experiments were performed in poliovirus-susceptible TgPVR21 mice. Results We show that monoclonal antibody A12 effectively neutralizes in vitro a broad range of type 1 and type 2 wild and vaccine-derived polioviruses, provides effective pre- and post-exposure protection of TgPVR21 mice from challenge with a lethal dose of poliovirus. Treatment of animals with the antibody concurrent with IPV immunization does not prevent immune response to the vaccine. Conclusions Anti-poliovirus antibody A12 effectively neutralizes a range of wild and VDPV strains and protectstransgenic mice susceptible to poliovirus against lethal challenge upon pre- and post-exposure administration. This suggests that the antibodies could be used in combination with drugs and/or vaccine to improve their efficacy and prevent emergence of resistant variants, and provides a justification for initiating their clinical evaluation. JF - Journal of Clinical Virology AU - Kouiavskaia, Diana AU - Chen, Zhaochun AU - Dragunsky, Eugenia AU - Mirochnitchenko, Olga AU - Purcell, Robert AU - Chumakov, Konstantin AD - Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Building 52, Room 1126, Silver Spring, MD 20993-0002, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 32 EP - 37 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 65 SN - 1386-6532, 1386-6532 KW - Toxicology Abstracts; Virology & AIDS Abstracts KW - Polio eradication KW - Antiviral therapy KW - Drug-resistance KW - Chronic virus excretors KW - Emergency prophylaxis KW - Poliovirus KW - Serotypes KW - Monoclonal antibodies KW - Drug resistance KW - Drug development KW - Immunosuppressive agents KW - Vaccination KW - Antiviral agents KW - Immunogenicity KW - Vaccines KW - Immune response KW - Lethal dose KW - X 24310:Pharmaceuticals KW - V 22350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732815754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=A+single+chimpanzee-human+neutralizing+monoclonal+antibody+provides+post-exposure+protection+against+type+1+and+type+2+polioviruses&rft.au=Kouiavskaia%2C+Diana%3BChen%2C+Zhaochun%3BDragunsky%2C+Eugenia%3BMirochnitchenko%2C+Olga%3BPurcell%2C+Robert%3BChumakov%2C+Konstantin&rft.aulast=Kouiavskaia&rft.aufirst=Diana&rft.date=2015-04-01&rft.volume=65&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2015.01.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Serotypes; Antiviral agents; Immunogenicity; Monoclonal antibodies; Drug resistance; Drug development; Immune response; Vaccines; Vaccination; Immunosuppressive agents; Lethal dose; Poliovirus DO - http://dx.doi.org/10.1016/j.jcv.2015.01.023 ER - TY - JOUR T1 - Validation of an HPLC-MS/MS and Wipe Procedure for Mitomycin C Contamination AN - 1717497239; PQ0001720333 AB - A high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method was developed for the determination of mitomycin C, an anticancer drug, from contamination on various surfaces. Mitomycin C is often used in various forms of intraperitoneal chemotherapy, and operating room healthcare worker exposure to this drug is possible. The surface testing method consisted of a wiping procedure utilizing a solution of 20/45/35 (v/v/v) of acetonitrile-isopropanol-water made 0.01 M in ammonium citrate (apparent pH 7.0). The wipe solutions were analyzed by means of HPLC-MS/MS using a reversed-phase gradient system and electrospray ionization in positive ion mode with a triple-quadrupole MS detector. Accuracy and precision of this method were demonstrated by a series of recovery studies of both spiked solutions and extracted wipes from various surfaces (stainless steel, vinyl and Formica(R)) spiked with known levels of mitomycin C. Recoveries of spiked solutions containing the analyte demonstrate mean recoveries (accuracy) ranged from 93 to 105%. Precision as measured by the relative standard deviation (% RSD) of multiple samples (n= 10) at each concentration level demonstrated values of 7.5% or less. The recoveries from spiked surfaces varied from 30 to 99%. The limit of detection for this methodology is ~2 ng/100 cm super(2) equivalent surface area, and the limit of quantitation is ~6 ng/100 cm super(2). JF - Journal of Chromatographic Science AU - B'Hymer, Clayton AU - Connor, Thomas AU - Stinson, Derek AU - Pretty, Jack AD - U.S. Department of Health and Human Services, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Taft Laboratory C-23, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, cbhymer@cdc.gov Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 619 EP - 624 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 53 IS - 4 SN - 0021-9665, 0021-9665 KW - Health & Safety Science Abstracts KW - Ammonium KW - Contamination KW - Chemotherapy KW - Surface area KW - Steel KW - Drugs KW - Medical personnel KW - pH KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717497239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatographic+Science&rft.atitle=Validation+of+an+HPLC-MS%2FMS+and+Wipe+Procedure+for+Mitomycin+C+Contamination&rft.au=B%27Hymer%2C+Clayton%3BConnor%2C+Thomas%3BStinson%2C+Derek%3BPretty%2C+Jack&rft.aulast=B%27Hymer&rft.aufirst=Clayton&rft.date=2015-04-01&rft.volume=53&rft.issue=4&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatographic+Science&rft.issn=00219665&rft_id=info:doi/10.1093%2Fchromsci%2Fbmu095 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Ammonium; Contamination; Surface area; Chemotherapy; Steel; Drugs; pH; Medical personnel DO - http://dx.doi.org/10.1093/chromsci/bmu095 ER - TY - JOUR T1 - PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML AN - 1701480068; PQ0001733817 AB - The transcription factor PU.1, encoded by the murine Sfpi1 gene (SPI1 in humans), is a member of the Ets transcription factor family and plays a vital role in commitment and maturation of the myeloid and lymphoid lineages. Murine studies directly link primary acute myeloid leukaemia (AML) and decreased PU.1 expression in specifically modified strains. Similarly, a radiation-induced chromosome 2 deletion and subsequent Sfpi1 point mutation in the remaining allele lead to murine radiation-induced AML. Consistent with murine data, heterozygous deletion of the SPI1 locus and mutation of the -14kb SPI1 upstream regulatory element were described previously in human primary AML, although they are rare events. Other mechanisms linked to PU.1 downregulation in human AML include TP53 deletion, FLT3-ITD mutation and the recurrent AML1-ETO [t(8; 21)] and PML-RARA [t(15; 17)] translocations. This review provides an up-to-date overview on our current understanding of the involvement of PU.1 in the initiation and development of radiation-induced AML, together with recommendations for future murine and human studies. JF - Carcinogenesis AU - Verbiest, Tom AU - Bouffler, Simon AU - Nutt, Stephen L AU - Badie, Christophe Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 413 EP - 419 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 36 IS - 4 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Molecular modelling KW - Data processing KW - Regulatory sequences KW - Point mutation KW - chromosome 2 KW - p53 protein KW - ETS protein KW - Gene deletion KW - Chromosome translocations KW - Reviews KW - Transcription factors KW - Carcinogenesis KW - Chromosome deletion KW - PU.1 protein KW - X 24500:Reviews, Legislation, Book & Conference Notices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701480068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=PU.1+downregulation+in+murine+radiation-induced+acute+myeloid+leukaemia+%28AML%29%3A+from+molecular+mechanism+to+human+AML&rft.au=Verbiest%2C+Tom%3BBouffler%2C+Simon%3BNutt%2C+Stephen+L%3BBadie%2C+Christophe&rft.aulast=Verbiest&rft.aufirst=Tom&rft.date=2015-04-01&rft.volume=36&rft.issue=4&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgv016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Data processing; Regulatory sequences; Point mutation; chromosome 2; ETS protein; p53 protein; Gene deletion; Chromosome translocations; Transcription factors; Reviews; Chromosome deletion; Carcinogenesis; PU.1 protein DO - http://dx.doi.org/10.1093/carcin/bgv016 ER - TY - JOUR T1 - Laser 3D Printing with Sub-Microscale Resolution of Porous Elastomeric Scaffolds for Supporting Human Bone Stem Cells AN - 1694976188; PQ0001663752 AB - A reproducible method is needed to fabricate 3D scaffold constructs that results in periodic and uniform structures with precise control at sub-micrometer and micrometer length scales. In this study, fabrication of scaffolds by two-photon polymerization (2PP) of a biodegradable urethane and acrylate-based photoelastomer is demonstrated. This material supports 2PP processing with sub-micrometer spatial resolution. The high photoreactivity of the biophotoelastomer permits 2PP processing at a scanning speed of 1000 mm s super(-1), facilitating rapid fabrication of relatively large structures (>5 mm super(3)). These structures are custom printed for in vitro assay screening in 96-well plates and are sufficiently flexible to enable facile handling and transplantation. These results indicate that stable scaffolds with porosities of greater than 60% can be produced using 2PP. Human bone marrow stromal cells grown on 3D scaffolds exhibit increased growth and proliferation compared to smooth 2D scaffold controls. 3D scaffolds adsorb larger amounts of protein than smooth 2D scaffolds due to their larger surface area; the scaffolds also allow cells to attach in multiple planes and to completely infiltrate the porous scaffolds. The flexible photoelastomer material is biocompatible in vitro and is associated with facile handling, making it a viable candidate for further study of complex 3D-printed scaffolds. The fabrication of scaffolds by two-photon polymerization (2PP) of a biodegradable urethane and acrylate-based photoelastomer is demonstrated. This material supports 2PP processing with sub-micrometer spatial resolution. The high photoreactivity of the biophoto-elastomer permits 2PP processing at a scanning speed of 1000 mm s super(-1), facilitating rapid fabrication of large structures (>5 mm super(3)). Stable scaffolds with porosities of greater than 60% can be produced using 2PP. JF - Advanced Healthcare Materials AU - Petrochenko, Peter E AU - Torgersen, Jan AU - Gruber, Peter AU - Hicks, Lucas A AU - Zheng, Jiwen AU - Kumar, Girish AU - Narayan, Roger J AU - Goering, Peter L AU - Liska, Robert AU - Stampfl, Juergen AU - Ovsianikov, Aleksandr AD - Office of Science and Engineering Laboratories, U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA. Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 739 EP - 747 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 4 IS - 5 SN - 2192-2640, 2192-2640 KW - Toxicology Abstracts; Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Polymerization KW - Printing KW - stromal cells KW - Surface area KW - Porosity KW - Bone marrow KW - spatial discrimination KW - Biodegradability KW - Elastomers KW - scaffolds KW - Stem cells KW - Scanning KW - Lasers KW - Cell proliferation KW - urethane KW - X 24390:Radioactive Materials KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694976188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Healthcare+Materials&rft.atitle=Laser+3D+Printing+with+Sub-Microscale+Resolution+of+Porous+Elastomeric+Scaffolds+for+Supporting+Human+Bone+Stem+Cells&rft.au=Petrochenko%2C+Peter+E%3BTorgersen%2C+Jan%3BGruber%2C+Peter%3BHicks%2C+Lucas+A%3BZheng%2C+Jiwen%3BKumar%2C+Girish%3BNarayan%2C+Roger+J%3BGoering%2C+Peter+L%3BLiska%2C+Robert%3BStampfl%2C+Juergen%3BOvsianikov%2C+Aleksandr&rft.aulast=Petrochenko&rft.aufirst=Peter&rft.date=2015-04-01&rft.volume=4&rft.issue=5&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Advanced+Healthcare+Materials&rft.issn=21922640&rft_id=info:doi/10.1002%2Fadhm.201400442 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Printing; Polymerization; stromal cells; Surface area; Porosity; Bone marrow; spatial discrimination; Elastomers; Biodegradability; scaffolds; Stem cells; Scanning; Lasers; Cell proliferation; urethane DO - http://dx.doi.org/10.1002/adhm.201400442 ER - TY - JOUR T1 - Unstable Sitting in the Workplace-Are There Physical Activity Benefits? AN - 1694968386; PQ0001516877 AB - The increasingly popular practice of using a stability ball (exercise/fitness ball) as a sitting surface runs counter to conventional human factors/'ergonomics guidelines for seated workspace design. Employees sitting on stability balls in an office environment present safely risks that might be justifiable if the practice has a definitive benefit to the promotion of health. However, the published studies and best evidence to date call into question even, the theoretical basis for this practice and. do not suggest, significant health benefits. First, biomechanical studies do not confirm the intended trunk muscle activation. Second, energy expenditure studies show a small (if any) increase in metabolic demand that is unlikely to be effective in combating sedentary work risk factors. Until studies demonstrate more conclusive benefits, the practice of stability ball sitting should, be vieioed skeptically as a general, workplace recommendation in the interest of health or wellness. JF - American Journal of Health Promotion AU - Lowe, Brian D AU - Swanson, Naomi G AU - Hudock, Stephen D AU - Lotz, W Gregory AD - Division of Applied Research and Technolog, National Institute for Occupational Safety and Health, 1090 Tusculum Ave., MS C-24, Cincinnati, OH 45226, blowe@cdc.gov PY - 2015 SP - 207 EP - 209 PB - American Journal of Health Promotion, 1660 Cass Lake Road, Suite 104 Keego Harbor MI 48320 United States VL - 29 IS - 4 SN - 0890-1171, 0890-1171 KW - Risk Abstracts; Health & Safety Science Abstracts; Physical Education Index KW - Physical activity KW - Promotion KW - Running KW - Guidelines KW - Muscles KW - Health KW - Exercise KW - Practice KW - Working conditions KW - Risk factors KW - Energy KW - Wellness KW - Human factors KW - Sitting KW - Balance KW - Biomechanics KW - Ergonomics KW - Health promotion KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694968386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion&rft.atitle=Unstable+Sitting+in+the+Workplace-Are+There+Physical+Activity+Benefits%3F&rft.au=Lowe%2C+Brian+D%3BSwanson%2C+Naomi+G%3BHudock%2C+Stephen+D%3BLotz%2C+W+Gregory&rft.aulast=Lowe&rft.aufirst=Brian&rft.date=2015-04-01&rft.volume=29&rft.issue=4&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion&rft.issn=08901171&rft_id=info:doi/10.4278%2Fajhp.140331-CIT-127 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Running; Promotion; Wellness; Health; Exercise; Sitting; Practice; Balance; Ergonomics; Energy; Physical activity; Risk factors; Guidelines; Muscles; Human factors; Working conditions; Biomechanics; Health promotion DO - http://dx.doi.org/10.4278/ajhp.140331-CIT-127 ER - TY - JOUR T1 - How Long Can Stool Samples Be Fixed for an Accurate Diagnosis of Soil-Transmitted Helminth Infection Using Mini-FLOTAC? AN - 1685635907 AB - Background Kato-Katz is a widely used method for the diagnosis of soil-transmitted helminth infection. Fecal samples cannot be preserved, and hence, should be processed on the day of collection and examined under a microscope within 60 min of slide preparation. Mini-FLOTAC is a technique that allows examining fixed fecal samples. We assessed the performance of Mini-FLOTAC using formalin-fixed stool samples compared to Kato-Katz and determined the dynamics of prevalence and intensity estimates of soil-transmitted helminth infection over a 31-day time period. Methodology The study was carried out in late 2013 on Pemba Island, Tanzania. Forty-one children were enrolled and stool samples were subjected on the day of collection to a single Kato-Katz thick smear and Mini-FLOTAC examination; 12 aliquots of stool were fixed in 5% formalin and subsequently examined by Mini-FLOTAC up to 31 days after collection. Principal Findings The combined results from Kato-Katz and Mini-FLOTAC revealed that 100% of children were positive for Trichuris trichiura, 85% for Ascaris lumbricoides, and 54% for hookworm. Kato-Katz and Mini-FLOTAC techniques found similar prevalence estimates for A. lumbricoides (85% versus 76%), T. trichiura (98% versus 100%), and hookworm (42% versus 51%). The mean eggs per gram of stool (EPG) according to Kato-Katz and Mini-FLOTAC was 12,075 and 11,679 for A. lumbricoides, 1,074 and 1,592 for T. trichiura, and 255 and 220 for hookworm, respectively. The mean EPG from day 1 to 31 of fixation was stable for A. lumbricoides and T. trichiura, but gradually declined for hookworm, starting at day 15. Conclusions/Significance The findings of our study suggest that for a qualitative diagnosis of soil-transmitted helminth infection, stool samples can be fixed in 5% formalin for at least 30 days. However, for an accurate quantitative diagnosis of hookworm, we suggest a limit of 15 days of preservation. Our results have direct implication for integrating soil-transmitted helminthiasis into transmission assessment surveys for lymphatic filariasis. JF - PLoS Neglected Tropical Diseases AU - Barda, Beatrice AU - Albonico, Marco AU - Ianniello, Davide AU - Ame, Shaali M AU - Keiser, Jennifer AU - Speich, Benjamin AU - Rinaldi, Laura AU - Cringoli, Giuseppe AU - Burioni, Roberto AU - Montresor, Antonio AU - Utzinger, Jürg Y1 - 2015/04// PY - 2015 DA - Apr 2015 CY - San Francisco PB - Public Library of Science VL - 9 IS - 4 KW - Medical Sciences--Communicable Diseases KW - Laboratories KW - Public health KW - Studies KW - Infections KW - Tropical diseases KW - Eggs KW - Parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1685635907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=How+Long+Can+Stool+Samples+Be+Fixed+for+an+Accurate+Diagnosis+of+Soil-Transmitted+Helminth+Infection+Using+Mini-FLOTAC%3F%3A+e0003698&rft.au=Barda%2C+Beatrice%3BAlbonico%2C+Marco%3BIanniello%2C+Davide%3BAme%2C+Shaali+M%3BKeiser%2C+Jennifer%3BSpeich%2C+Benjamin%3BRinaldi%2C+Laura%3BCringoli%2C+Giuseppe%3BBurioni%2C+Roberto%3BMontresor%2C+Antonio%3BUtzinger%2C+J%C3%BCrg&rft.aulast=Barda&rft.aufirst=Beatrice&rft.date=2015-04-01&rft.volume=9&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pntd.0003698 LA - English DB - ProQuest Central N1 - Name - World Health Organization N1 - Copyright - © 2015 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Barda B, Albonico M, Ianniello D, Ame SM, Keiser J, Speich B, et al. (2015) How Long Can Stool Samples Be Fixed for an Accurate Diagnosis of Soil-Transmitted Helminth Infection Using Mini-FLOTAC? PLoS Negl Trop Dis 9(4): e0003698. doi:10.1371/journal.pntd.0003698 N1 - Last updated - 2015-06-04 DO - http://dx.doi.org/10.1371/journal.pntd.0003698 ER - TY - JOUR T1 - Estimating the Benefits of Public Health Policies that Reduce Harmful Consumption AN - 1683503391 AB - For products such as tobacco and junk food, where policy interventions are often designed to decrease consumption, affected consumers gain utility from improvements in lifetime health and longevity but also lose utility associated with the activity of consuming the product. In the case of anti-smoking policies, even though published estimates of gross health and longevity benefits are up to 900 times higher than the net consumer benefits suggested by a more direct willingness-to-pay estimation approach, there is little recognition in the cost-benefit and cost-effectiveness literature that gross estimates will overstate intrapersonal welfare improvements when utility losses are not netted out. This paper presents a general framework for analyzing policies that are designed to reduce inefficiently high consumption and provides a rule of thumb for the relationship between net and gross consumer welfare effects: where there exists a plausible estimate of the tax that would allow consumers to fully internalize health costs, the ratio of the tax to the per-unit long-term cost can provide an upper bound on the ratio of net to gross benefits. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Health Economics AU - Ashley, Elizabeth M AU - Nardinelli, Clark AU - Lavaty, Rosemarie A AD - Food and Drug Administration, Silver Spring, MD, USA. ; Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 617 EP - 624 CY - York PB - Wiley Subscription Services, Inc. VL - 24 IS - 5 SN - 1057-9230 KW - Business And Economics--Economic Situation And Conditions KW - Consumer behaviour KW - Benefits KW - Cessation KW - Public domain KW - Public health KW - Smoking KW - Taxation KW - Tobacco KW - Welfare effects KW - Willingness to pay KW - Consumers KW - Cost benefit analysis KW - Cost effectiveness KW - Food consumption KW - Health costs KW - Healthy food KW - Interventions KW - Longevity KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683503391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Estimating+the+Benefits+of+Public+Health+Policies+that+Reduce+Harmful+Consumption&rft.au=Ashley%2C+Elizabeth+M%3BNardinelli%2C+Clark%3BLavaty%2C+Rosemarie+A&rft.aulast=Ashley&rft.aufirst=Elizabeth&rft.date=2015-04-01&rft.volume=24&rft.issue=5&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.3040 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright John Wiley & Sons, Inc. Apr 2015 N1 - Date revised - 2015-04-15 N1 - Last updated - 2016-11-17 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1002/hec.3040 ER - TY - JOUR T1 - Elastography: history, principles, and technique comparison AN - 1680434828; PQ0001477701 AB - Elastography is a relatively new imaging technology that creates images of tissue stiffness. It can be thought of an extension of the ancient technique of palpation but it gives better spatial localization information and is less subjective. Two main types of elastography are currently in use, strain elastography where the tissue displacement in response to gentle pressure is used to compute and image tissue strain, and shear wave elastography where the speed of shear waves traversing tissue is measured and used to create an image of tissue stiffness. Each method has advantages and disadvantages but generally strain imaging is excellent for focal lesions and shear wave imaging, being more quantitative, is best for diffuse organ diseases. Strain imaging requires additional training in acquisition technique to obtain high quality images. Pitfalls to avoid and tips for good images are provided. Improvements in strain imaging are focused on better quality indicators and better methods for quantification. Improvements in shear wave imaging will be higher frame rates, greater accuracy in focal lesions, and making results more comparable between different ultrasound systems. Both methods will continue to improve and will provide ever more powerful new tools for diagnosis of diffuse and focal diseases. JF - Abdominal Imaging AU - Garra, Brian S AD - Washington DC VA Medical Center, Washington, DC, USA, brian.garra@fda.hhs.gov Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 680 EP - 697 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 40 IS - 4 SN - 0942-8925, 0942-8925 KW - Biotechnology and Bioengineering Abstracts KW - Waves KW - spatial discrimination KW - Pressure KW - imaging KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680434828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abdominal+Imaging&rft.atitle=Elastography%3A+history%2C+principles%2C+and+technique+comparison&rft.au=Garra%2C+Brian+S&rft.aulast=Garra&rft.aufirst=Brian&rft.date=2015-04-01&rft.volume=40&rft.issue=4&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Abdominal+Imaging&rft.issn=09428925&rft_id=info:doi/10.1007%2Fs00261-014-0305-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 41 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - spatial discrimination; Waves; Pressure; Ultrasound; imaging DO - http://dx.doi.org/10.1007/s00261-014-0305-8 ER - TY - JOUR T1 - Sequence of Pathogenic Events in Cynomolgus Macaques Infected with Aerosolized Monkeypox Virus AN - 1676353749; PQ0001421923 AB - To evaluate new vaccines when human efficacy studies are not possible, the FDA's "Animal Rule" requires well-characterized models of infection. Thus, in the present study, the early pathogenic events of monkeypox infection in nonhuman primates, a surrogate for variola virus infection, were characterized. Cynomolgus macaques were exposed to aerosolized monkeypox virus (105 PFU). Clinical observations, viral loads, immune responses, and pathological changes were examined on days 2, 4, 6, 8, 10, and 12 postchallenge. Viral DNA (vDNA) was detected in the lungs on day 2 postchallenge, and viral antigen was detected, by immunostaining, in the epithelium of bronchi, bronchioles, and alveolar walls. Lesions comprised rare foci of dysplastic and sloughed cells in respiratory bronchioles. By day 4, vDNA was detected in the throat, tonsil, and spleen, and monkeypox antigen was detected in the lung, hilar and submandibular lymph nodes, spleen, and colon. Lung lesions comprised focal epithelial necrosis and inflammation. Body temperature peaked on day 6, pox lesions appeared on the skin, and lesions, with positive immunostaining, were present in the lung, tonsil, spleen, lymph nodes, and colon. By day 8, vDNA was present in 9/13 tissues. Blood concentrations of interleukin 1ra (IL-1ra), IL-6, and gamma interferon (IFN- gamma ) increased markedly. By day 10, circulating IgG antibody concentrations increased, and on day 12, animals showed early signs of recovery. These results define early events occurring in an inhalational macaque monkeypox infection model, supporting its use as a surrogate model for human smallpox. IMPORTANCE Bioterrorism poses a major threat to public health, as the deliberate release of infectious agents, such smallpox or a related virus, monkeypox, would have catastrophic consequences. The development and testing of new medical countermeasures, e.g., vaccines, are thus priorities; however, tests for efficacy in humans cannot be performed because it would be unethical and field trials are not feasible. To overcome this, the FDA may grant marketing approval of a new product based upon the "Animal Rule," in which interventions are tested for efficacy in well-characterized animal models. Monkeypox virus infection of nonhuman primates (NHPs) presents a potential surrogate disease model for smallpox. Previously, the later stages of monkeypox infection were defined, but the early course of infection remains unstudied. Here, the early pathogenic events of inhalational monkeypox infection in NHPs were characterized, and the results support the use of this surrogate model for testing human smallpox interventions. JF - Journal of Virology AU - Tree, J A AU - Hall, G AU - Pearson, G AU - Rayner, E AU - Graham, V A AU - Steeds, K AU - Bewley, K R AU - Hatch, G J AU - Dennis, M AU - Taylor, I Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 4335 EP - 4344 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 8 SN - 0022-538X, 0022-538X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Interleukin 6 KW - gamma -Interferon KW - Pharynx KW - Body temperature KW - bioterrorism KW - Animal models KW - Intervention KW - Infection KW - Interleukin 1 receptor antagonist KW - Public health KW - Necrosis KW - Colon KW - Tonsil KW - Bronchus KW - Marketing KW - Lesions KW - Cynomolgus KW - Epithelium KW - Monkeypox virus KW - Variola virus KW - Monkeypox KW - Macaca KW - Disasters KW - Temperature KW - Spleen KW - Bioterrorism KW - Primates KW - Alveoli KW - Lymph nodes KW - Inflammation KW - Smallpox KW - Blood KW - Skin diseases KW - Lung KW - FDA KW - DNA KW - Immunoglobulin G KW - Priorities KW - Vaccines KW - Immune response KW - V 22350:Immunology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676353749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Sequence+of+Pathogenic+Events+in+Cynomolgus+Macaques+Infected+with+Aerosolized+Monkeypox+Virus&rft.au=Tree%2C+J+A%3BHall%2C+G%3BPearson%2C+G%3BRayner%2C+E%3BGraham%2C+V+A%3BSteeds%2C+K%3BBewley%2C+K+R%3BHatch%2C+G+J%3BDennis%2C+M%3BTaylor%2C+I&rft.aulast=Tree&rft.aufirst=J&rft.date=2015-04-01&rft.volume=89&rft.issue=8&rft.spage=4335&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.03029-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 33 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Interleukin 6; gamma -Interferon; Pharynx; Body temperature; bioterrorism; Animal models; Infection; Interleukin 1 receptor antagonist; Public health; Necrosis; Bronchus; Tonsil; Colon; Epithelium; Monkeypox; Spleen; Lymph nodes; Alveoli; Inflammation; Smallpox; Blood; Skin diseases; Lung; Immunoglobulin G; DNA; Immune response; Vaccines; Temperature; Disasters; Intervention; Bioterrorism; Primates; Marketing; FDA; Lesions; Priorities; Macaca; Cynomolgus; Variola virus; Monkeypox virus DO - http://dx.doi.org/10.1128/JVI.03029-14 ER - TY - JOUR T1 - The Transient Dermal Exposure II: Post-Exposure Absorption and Evaporation of Volatile Compounds AN - 1673384597; PQ0001281705 AB - The transient dermal exposure is one where the skin is exposed to chemical for a finite duration, after which the chemical is removed and no residue remains on the skin's surface. Chemical within the skin at the end of the exposure period can still enter the systemic circulation. If it has some volatility, a portion of it will evaporate from the surface before it has a chance to be absorbed by the body. The fate of this post-exposure "skin depot" is the focus of this theoretical study. Laplace domain solutions for concentration distribution, flux, and cumulative mass absorption and evaporation are presented, and time domain results are obtained through numerical inversion. The Final Value Theorem is applied to obtain the analytical solutions for the total fractional absorption by the body and evaporation from skin at infinite time following a transient exposure. The solutions depend on two dimensionless variables: chi , the ratio of evaporation rate to steady-state dermal permeation rate; and the ratio of exposure time to membrane lag time. Simple closed form algebraic equations are presented that closely approximate the complete analytical solutions. Applications of the theory to the dermal risk assessment of pharmaceutical, occupational, and environmental exposures are presented for four example chemicals. copyright 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:1499-1507, 2015 JF - Journal of Pharmaceutical Sciences AU - Frasch, HFrederick AU - Bunge, Annette L AD - Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 1499 EP - 1507 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 4 SN - 0022-3549, 0022-3549 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Membranes KW - Skin KW - Mathematical models KW - Residues KW - Evaporation KW - Uncertainty KW - Volatiles KW - Inversion KW - Absorption KW - Pharmaceuticals KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673384597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=The+Transient+Dermal+Exposure+II%3A+Post-Exposure+Absorption+and+Evaporation+of+Volatile+Compounds&rft.au=Frasch%2C+HFrederick%3BBunge%2C+Annette+L&rft.aulast=Frasch&rft.aufirst=HFrederick&rft.date=2015-04-01&rft.volume=104&rft.issue=4&rft.spage=1499&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mathematical models; Skin; Inversion; Volatiles; Evaporation; Pharmaceuticals; Occupational exposure; Uncertainty; Membranes; Residues; Absorption DO - http://dx.doi.org/10.1002/jps.24334 ER - TY - JOUR T1 - Sex hormone modulation of both induction and inhibition of CYP1A by genistein in HepG2/C3A cells. AN - 1671210105; 25479735 AB - Genistein is a widely consumed phytoestrogen in dietary supplements and has been reported to play roles in both cancer prevention and promotion. These conflicting effects may be complicated by sex differences. Cytochrome P450 1A (CYP1A) participates in carcinogen activation and detoxification, and the enzyme may interact with genistein. Therefore, modulation of CYP1A by a combination of genistein and sex hormones could be responsible for sex differences related to cancer prevention and promotion. In the current study, a human liver cell line, HepG2/C3A, cultured in sex hormone-supplemented media was used to investigate the modulatory effect of genistein on CYP1A gene expression and activity. Genistein exerted both long-term (72 h) induction and short-term (immediate) inhibition of CYP1A activity in HepG2/C3A cells. In the long-term study, CYP1A gene expression and enzyme activity were induced to a greater extent in male hormone-supplemented cells than female ones. In the short-term study, CYP1A activity was inhibited more strongly by genistein in the male hormone-supplemented cells than in the female hormone-supplemented cells. These significant differences suggest that male hormones can modulate the effects of genistein on CYP1A gene expression and activity. JF - In vitro cellular & developmental biology. Animal AU - Liu, Yitong AU - Santillo, Michael F AU - Flynn, Thomas J AU - Ferguson, Martine S AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA, yitong.liu@fda.hhs.gov. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 426 EP - 431 VL - 51 IS - 4 KW - Benzoflavones KW - 0 KW - Gonadal Steroid Hormones KW - Testosterone KW - 3XMK78S47O KW - alpha-naphthoflavone KW - 604-59-1 KW - beta-Naphthoflavone KW - 6051-87-2 KW - Genistein KW - DH2M523P0H KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1A1 protein, human KW - CYP1A2 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1A2 KW - Index Medicus KW - Cytochrome P-450 CYP1A1 -- genetics KW - Testosterone -- pharmacology KW - Cytochrome P-450 CYP1A2 -- genetics KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Humans KW - beta-Naphthoflavone -- pharmacology KW - Hep G2 Cells -- drug effects KW - Male KW - Female KW - Benzoflavones -- pharmacology KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Gonadal Steroid Hormones -- pharmacology KW - Genistein -- pharmacology KW - Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671210105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vitro+cellular+%26+developmental+biology.+Animal&rft.atitle=Sex+hormone+modulation+of+both+induction+and+inhibition+of+CYP1A+by+genistein+in+HepG2%2FC3A+cells.&rft.au=Liu%2C+Yitong%3BSantillo%2C+Michael+F%3BFlynn%2C+Thomas+J%3BFerguson%2C+Martine+S&rft.aulast=Liu&rft.aufirst=Yitong&rft.date=2015-04-01&rft.volume=51&rft.issue=4&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=In+vitro+cellular+%26+developmental+biology.+Animal&rft.issn=1543-706X&rft_id=info:doi/10.1007%2Fs11626-014-9848-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-25 N1 - Date created - 2015-04-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s11626-014-9848-9 ER - TY - JOUR T1 - Global analysis of posttranscriptional gene expression in response to sodium arsenite. AN - 1669841604; 25493608 AB - Inorganic arsenic species are potent environmental toxins and causes of numerous health problems. Most studies have assumed that arsenic-induced changes in mRNA levels result from effects on gene transcription. We evaluated the prevalence of changes in mRNA stability in response to sodium arsenite in human fibroblasts. We used microarray analyses to determine changes in steady-state mRNA levels and mRNA decay rates following 24-hr exposure to noncytotoxic concentrations of sodium arsenite, and we confirmed some of these changes using real-time reverse-transcription polymerase chain reaction (RT-PCR). In arsenite-exposed cells, 186 probe set-identified transcripts were significantly increased and 167 were significantly decreased. When decay rates were analyzed after actinomycin D treatment, only 4,992 (9.1%) of probe set-identified transcripts decayed by > 25% after 4 hr. Of these, 70 were among the 353 whose steady-state levels were altered by arsenite, and of these, only 4 exhibited significantly different decay rates between arsenite and control treatment. Real-time RT-PCR confirmed a major, significant arsenite-induced stabilization of the mRNA encoding δ aminolevulinate synthase 1 (ALAS1), the rate-limiting enzyme in heme biosynthesis. This change presumably accounted for at least part of the 2.7-fold increase in steady-state ALAS1 mRNA levels seen after arsenite treatment. This could reflect decreases in cellular heme caused by the massive induction by arsenite of heme oxygenase mRNA (HMOX1; 68-fold increase), the rate-limiting enzyme in heme catabolism. We conclude that arsenite modification of mRNA stability is relatively uncommon, but in some instances can result in significant changes in gene expression. JF - Environmental health perspectives AU - Qiu, Lian-Qun AU - Abey, Sarah AU - Harris, Shawn AU - Shah, Ruchir AU - Gerrish, Kevin E AU - Blackshear, Perry J AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 324 EP - 330 VL - 123 IS - 4 KW - Arsenites KW - 0 KW - Environmental Pollutants KW - RNA, Messenger KW - Sodium Compounds KW - Dactinomycin KW - 1CC1JFE158 KW - sodium arsenite KW - 48OVY2OC72 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - 5-Aminolevulinate Synthetase KW - EC 2.3.1.37 KW - Index Medicus KW - Dactinomycin -- pharmacology KW - Cells, Cultured KW - Humans KW - Male KW - Fibroblasts -- drug effects KW - Environmental Pollutants -- toxicity KW - Heme Oxygenase-1 -- metabolism KW - Arsenites -- toxicity KW - Sodium Compounds -- toxicity KW - 5-Aminolevulinate Synthetase -- metabolism KW - 5-Aminolevulinate Synthetase -- genetics KW - Heme Oxygenase-1 -- genetics KW - Gene Expression Regulation -- drug effects KW - Fibroblasts -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669841604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Global+analysis+of+posttranscriptional+gene+expression+in+response+to+sodium+arsenite.&rft.au=Qiu%2C+Lian-Qun%3BAbey%2C+Sarah%3BHarris%2C+Shawn%3BShah%2C+Ruchir%3BGerrish%2C+Kevin+E%3BBlackshear%2C+Perry+J&rft.aulast=Qiu&rft.aufirst=Lian-Qun&rft.date=2015-04-01&rft.volume=123&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408626 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-27 N1 - Date created - 2015-04-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):557-64 [15996700] Bioinformatics. 2005 Oct 15;21(20):3933-4 [16109745] Cancer Res. 2005 Dec 1;65(23):10977-83 [16322246] Nucleic Acids Res. 2006;34(2):485-95 [16421274] Toxicol Appl Pharmacol. 2006 Nov 1;216(3):407-15 [16876216] Mol Cell Biol. 2006 Dec;26(24):9196-208 [17030620] Biostatistics. 2007 Apr;8(2):414-32 [16928955] Tohoku J Exp Med. 2007 Sep;213(1):1-16 [17785948] J Cell Physiol. 2008 Mar;214(3):796-809 [17849448] Exp Biol Med (Maywood). 2008 Mar;233(3):377-84 [18296743] Toxicol Appl Pharmacol. 2008 Mar 15;227(3):400-16 [18191166] Environ Health Perspect. 2008 Apr;116(4):524-31 [18414638] Cytokine Growth Factor Rev. 2008 Jun-Aug;19(3-4):245-51 [18524667] Toxicol Appl Pharmacol. 2008 Dec 15;233(3):389-403 [18929588] Toxicol In Vitro. 2009 Feb;23(1):148-57 [19000923] BMC Genomics. 2010;11:282 [20444259] Arch Toxicol. 2010 Aug;84(8):585-96 [20502880] J Appl Toxicol. 2011 Mar;31(2):95-107 [21321970] BMC Genomics. 2011;12:173 [21457566] BMC Biol. 2011;9:34 [21627854] J Biol Chem. 2011 Jul 29;286(30):26424-30 [21659532] Toxicol Sci. 2011 Oct;123(2):305-32 [21750349] Biol Pharm Bull. 2011;34(11):1748-52 [22040890] J Immunol. 2012 May 15;188(10):5150-9 [22491258] Toxicol Lett. 2012 Jul 20;212(2):169-79 [22641096] J Biol Chem. 2000 May 19;275(20):15336-42 [10809768] Hepatology. 2001 May;33(5):1217-22 [11343251] Toxicol Sci. 2001 Jun;61(2):314-20 [11353140] Carcinogenesis. 2002 May;23(5):867-76 [12016162] Science. 2002 Jun 21;296(5576):2143-5 [12077387] Toxicol Lett. 2002 Jul 7;133(1):33-45 [12076508] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Environ Health Perspect. 2002 Oct;110 Suppl 5:883-6 [12426152] Carcinogenesis. 2003 Apr;24(4):747-56 [12727804] Toxicol Lett. 2003 Jul 20;143(2):155-62 [12749819] Mol Cell Biochem. 2004 Jan;255(1-2):57-66 [14971646] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):394-404 [15276419] J Cell Biol. 1971 Sep;50(3):746-61 [4398631] Cancer Res. 1973 Nov;33(11):2658-61 [4748426] Cancer Res. 1989 Jul 15;49(14):3776-82 [2736519] Mol Cell Biol. 1990 Sep;10(9):4967-9 [2388632] Folia Med Cracov. 1993;34(1-4):29-47 [8175062] Environ Health Perspect. 1998 Aug;106 Suppl 4:1005-15 [9703486] Methods Mol Biol. 2013;1064:91-100 [23996251] Nat Rev Immunol. 2014 Jun;14(6):361-76 [24854588] RNA Biol. 2014;11(8):1019-30 [25531407] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408626 ER - TY - JOUR T1 - FDA approval: idelalisib monotherapy for the treatment of patients with follicular lymphoma and small lymphocytic lymphoma. AN - 1669831515; 25645861 AB - On July 23, 2014, the FDA granted accelerated approval to idelalisib (Zydelig tablets; Gilead Sciences, Inc.) for the treatment of patients with relapsed follicular B-cell non-Hodgkin lymphoma or relapsed small lymphocytic lymphoma (SLL) who have received at least two prior systemic therapies. In a multicenter, single-arm trial, 123 patients with relapsed indolent non-Hodgkin lymphomas received idelalisib, 150 mg orally twice daily. In patients with follicular lymphoma, the overall response rate (ORR) was 54%, and the median duration of response (DOR) was not evaluable; median follow-up was 8.1 months. In patients with SLL, the ORR was 58% and the median DOR was 11.9 months. One-half of patients experienced a serious adverse reaction of pneumonia, pyrexia, sepsis, febrile neutropenia, diarrhea, or pneumonitis. Other common adverse reactions were abdominal pain, nausea, fatigue, cough, dyspnea, and rash. Common treatment-emergent laboratory abnormalities were elevations in alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, absolute lymphocytes, and triglycerides. Continued approval may be contingent upon verification of clinical benefit in confirmatory trials. ©2015 American Association for Cancer Research. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Miller, Barry W AU - Przepiorka, Donna AU - de Claro, R Angelo AU - Lee, Kyung AU - Nie, Lei AU - Simpson, Natalie AU - Gudi, Ramadevi AU - Saber, Haleh AU - Shord, Stacy AU - Bullock, Julie AU - Marathe, Dhananjay AU - Mehrotra, Nitin AU - Hsieh, Li Shan AU - Ghosh, Debasis AU - Brown, Janice AU - Kane, Robert C AU - Justice, Robert AU - Kaminskas, Edvardas AU - Farrell, Ann T AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Barry.Miller@fda.hhs.gov. ; Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Y1 - 2015/04/01/ PY - 2015 DA - 2015 Apr 01 SP - 1525 EP - 1529 VL - 21 IS - 7 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Purines KW - Quinazolinones KW - Class I Phosphatidylinositol 3-Kinases KW - EC 2.7.1.137 KW - Index Medicus KW - Humans KW - Quinazolinones -- therapeutic use KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Class I Phosphatidylinositol 3-Kinases -- antagonists & inhibitors KW - Lymphoma, Follicular -- drug therapy KW - Purines -- therapeutic use KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669831515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=FDA+approval%3A+idelalisib+monotherapy+for+the+treatment+of+patients+with+follicular+lymphoma+and+small+lymphocytic+lymphoma.&rft.au=Miller%2C+Barry+W%3BPrzepiorka%2C+Donna%3Bde+Claro%2C+R+Angelo%3BLee%2C+Kyung%3BNie%2C+Lei%3BSimpson%2C+Natalie%3BGudi%2C+Ramadevi%3BSaber%2C+Haleh%3BShord%2C+Stacy%3BBullock%2C+Julie%3BMarathe%2C+Dhananjay%3BMehrotra%2C+Nitin%3BHsieh%2C+Li+Shan%3BGhosh%2C+Debasis%3BBrown%2C+Janice%3BKane%2C+Robert+C%3BJustice%2C+Robert%3BKaminskas%2C+Edvardas%3BFarrell%2C+Ann+T%3BPazdur%2C+Richard&rft.aulast=Miller&rft.aufirst=Barry&rft.date=2015-04-01&rft.volume=21&rft.issue=7&rft.spage=1525&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-2522 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-02 N1 - Date created - 2015-04-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment On: Clin Cancer Res. 2015 Apr 1;21(7):1537-42 [25670221] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-2522 ER - TY - JOUR T1 - Detection and characterization of SiO2 and TiO2 nanostructures in dietary supplements. AN - 1669453325; 25738207 AB - Nanomaterials are beginning to enter our daily lives through various consumer products as the result of technology commercialization. The development of methodologies to detect the presence of nanomaterials in consumer products is an essential element in understanding our exposure. In this study, we have developed methods for the separation and characterization of silicon dioxide (SiO2) and titanium dioxide (TiO2) nanostructures in dietary supplements marketed in products specifically targeted for women. A total of 12 commercial products claiming the inclusion of SiO2 and TiO2, but not making any claims regarding the particle size, were randomly selected for purchase through various retailers. To isolate nanostructures from these products, a simple methodology that combines acid digestion and centrifugation was utilized. Once isolated, the chemical composition, size, morphology, and crystal structure were characterized using mass spectroscopy, light scattering, electron microscopy, and X-ray diffraction techniques. SiO2 and TiO2 nanostructures were detected in 11 of 12 products using these methods. Many of the isolated nanoscale materials showed a high degree of aggregation; however, identified individual structures had at least one dimension below 100 nm. These robust methods can be used for routine monitoring of commercial products for nanoscale oxides of silica and titanium. JF - Journal of agricultural and food chemistry AU - Lim, Jin-Hee AU - Sisco, Patrick AU - Mudalige, Thilak K AU - Sánchez-Pomales, Germarie AU - Howard, Paul C AU - Linder, Sean W AD - †Office of Regulatory Affairs, Arkansas Regional Laboratory, and ‡National Center for Toxicological Research, Office of Scientific Coordination, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, United States. Y1 - 2015/04/01/ PY - 2015 DA - 2015 Apr 01 SP - 3144 EP - 3152 VL - 63 IS - 12 KW - titanium dioxide KW - 15FIX9V2JP KW - Silicon Dioxide KW - 7631-86-9 KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - dietary supplements KW - nanomaterials KW - silicon dioxide KW - nanotechnology KW - X-Ray Diffraction KW - Nanostructures -- chemistry KW - Titanium -- chemistry KW - Dietary Supplements -- analysis KW - Silicon Dioxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669453325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Detection+and+characterization+of+SiO2+and+TiO2+nanostructures+in+dietary+supplements.&rft.au=Lim%2C+Jin-Hee%3BSisco%2C+Patrick%3BMudalige%2C+Thilak+K%3BS%C3%A1nchez-Pomales%2C+Germarie%3BHoward%2C+Paul+C%3BLinder%2C+Sean+W&rft.aulast=Lim&rft.aufirst=Jin-Hee&rft.date=2015-04-01&rft.volume=63&rft.issue=12&rft.spage=3144&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Facs.jafc.5b00392 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-29 N1 - Date created - 2015-04-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.jafc.5b00392 ER - TY - GEN T1 - Secondary pharmacology data to assess potential off-target activity of new drugs: a regulatory perspective. AN - 1669448821; 25792260 JF - Nature reviews. Drug discovery AU - Papoian, Thomas AU - Chiu, Haw-Jyh AU - Elayan, Ikram AU - Jagadeesh, Gowraganahalli AU - Khan, Imran AU - Laniyonu, Adebayo A AU - Li, Cindy Xinguang AU - Saulnier, Muriel AU - Simpson, Natalie AU - Yang, Baichun Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 294 VL - 14 IS - 4 KW - Index Medicus KW - Animals KW - Off-Label Use KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Cost-Benefit Analysis KW - Structure-Activity Relationship KW - Pharmacology, Clinical -- trends KW - Legislation, Drug -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669448821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Nature+reviews.+Drug+discovery&rft.atitle=Secondary+pharmacology+data+to+assess+potential+off-target+activity+of+new+drugs%3A+a+regulatory+perspective.&rft.au=Papoian%2C+Thomas%3BChiu%2C+Haw-Jyh%3BElayan%2C+Ikram%3BJagadeesh%2C+Gowraganahalli%3BKhan%2C+Imran%3BLaniyonu%2C+Adebayo+A%3BLi%2C+Cindy+Xinguang%3BSaulnier%2C+Muriel%3BSimpson%2C+Natalie%3BYang%2C+Baichun&rft.aulast=Papoian&rft.aufirst=Thomas&rft.date=2015-04-01&rft.volume=14&rft.issue=4&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Drug+discovery&rft.issn=1474-1784&rft_id=info:doi/10.1038%2Fnrd3845-c1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-01 N1 - Date created - 2015-04-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/nrd3845-c1 ER - TY - JOUR T1 - Trends in worker hearing loss by industry sector, 1981-2010 AN - 1668258093; PQ0001248720 AB - Background The purpose of this study was to estimate the incidence and prevalence of hearing loss for noise-exposed U.S. workers by industry sector and 5-year time period, covering 30 years. Methods Audiograms for 1.8 million workers from 1981-2010 were examined. Incidence and prevalence were estimated by industry sector and time period. The adjusted risk of incident hearing loss within each time period and industry sector as compared with a reference time period was also estimated. Results The adjusted risk for incident hearing loss decreased over time when all industry sectors were combined. However, the risk remained high for workers in Healthcare and Social Assistance, and the prevalence was consistently high for Mining and Construction workers. Conclusions While progress has been made in reducing the risk of incident hearing loss within most industry sectors, additional efforts are needed within Mining, Construction and Healthcare and Social Assistance. Am. J. Ind. Med. 58:392-401, 2015. copyright 2015 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Masterson, Elizabeth A AU - Deddens, James A AU - Themann, Christa L AU - Bertke, Stephen AU - Calvert, Geoffrey M AD - National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 392 EP - 401 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 4 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Health care KW - Hearing loss KW - Mining KW - Risk reduction KW - Construction industry KW - H 1000:Occupational Safety and Health KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668258093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Trends+in+worker+hearing+loss+by+industry+sector%2C+1981-2010&rft.au=Masterson%2C+Elizabeth+A%3BDeddens%2C+James+A%3BThemann%2C+Christa+L%3BBertke%2C+Stephen%3BCalvert%2C+Geoffrey+M&rft.aulast=Masterson&rft.aufirst=Elizabeth&rft.date=2015-04-01&rft.volume=58&rft.issue=4&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22429 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-29 N1 - SubjectsTermNotLitGenreText - Health care; Risk reduction; Mining; Hearing loss; Construction industry DO - http://dx.doi.org/10.1002/ajim.22429 ER - TY - JOUR T1 - Persistence of furan-induced epigenetic aberrations in the livers of F344 rats. AN - 1667352139; 25539665 AB - Furan is a heterocyclic organic compound produced in the chemical manufacturing industry and also found in a broad range of food products, including infant formulas and baby foods. Previous reports have indicated that the adverse biological effects of furan, including its liver tumorigenicity, may be associated with epigenetic abnormalities. In the present study, we investigated the persistence of epigenetic alterations in rat liver. Male F344 rats were treated by gavage 5 days per week with 8 mg furan/kg body weight (bw)/day for 90 days. After the last treatment, rats were divided randomly into 4 groups; 1 group of rats was sacrificed 24 h after the last treatment, whereas other groups were maintained without further furan treatment for an additional 90, 180, or 360 days. Treatment with furan for 90 days resulted in alterations in histone lysine methylation and acetylation, induction of base-excision DNA repair genes, suggesting oxidative damage to DNA, and changes in the gene expression in the livers. A majority of these furan-induced molecular changes was transient and disappeared after the cessation of furan treatment. In contrast, histone H3 lysine 9 and H3 lysine 56 showed a sustained and time-depended decrease in acetylation, which was associated with formation of heterochromatin and altered gene expression. These results indicate that furan-induced adverse effects may be mechanistically related to sustained changes in histone lysine acetylation that compromise the ability of cells to maintain and control properly the expression of genetic information. Published by Oxford University Press on behalf of the Society of Toxicology 2014. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - de Conti, Aline AU - Kobets, Tetyana AU - Tryndyak, Volodymyr AU - Burnett, Sarah D AU - Han, Tao AU - Fuscoe, James C AU - Beland, Frederick A AU - Doerge, Daniel R AU - Pogribny, Igor P AD - *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079. ; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079 igor.pogribny@fda.hhs.gov. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 217 EP - 226 VL - 144 IS - 2 KW - Furans KW - 0 KW - Histones KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - microarrays KW - liver carcinogenesis KW - gene expression profiling KW - genetic toxicology KW - Rats KW - Gene Expression Profiling KW - Animals KW - Acetylation KW - Rats, Inbred F344 KW - DNA Damage KW - Histones -- metabolism KW - Histones -- chemistry KW - Methylation KW - Male KW - Lysine -- metabolism KW - Liver -- drug effects KW - Furans -- toxicity KW - Epigenesis, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667352139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Persistence+of+furan-induced+epigenetic+aberrations+in+the+livers+of+F344+rats.&rft.au=de+Conti%2C+Aline%3BKobets%2C+Tetyana%3BTryndyak%2C+Volodymyr%3BBurnett%2C+Sarah+D%3BHan%2C+Tao%3BFuscoe%2C+James+C%3BBeland%2C+Frederick+A%3BDoerge%2C+Daniel+R%3BPogribny%2C+Igor+P&rft.aulast=de+Conti&rft.aufirst=Aline&rft.date=2015-04-01&rft.volume=144&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu313 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-14 N1 - Date created - 2015-03-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Crit Rev Toxicol. 2012 Jul;42(6):491-500 [22568498] Breast Cancer Res Treat. 2012 Jun;133(2):649-57 [22042362] Nat Cell Biol. 2012 Nov;14(11):1203-11 [23041974] Mol Cell. 2012 Nov 30;48(4):532-46 [23084836] Toxicol Sci. 2013 Jan;131(1):40-55 [23024176] Toxicol Sci. 2013 Oct;135(2):369-79 [23853263] Toxicol Appl Pharmacol. 2014 Jan 1;274(1):63-77 [24183702] Toxicol Sci. 2014 Jun;139(2):371-80 [24614236] Int J Cancer. 2014 Oct 15;135(8):1860-8 [24623538] Int J Cancer. 2014 Nov 1;135(9):2014-23 [24691920] Nucleic Acids Res. 2000 Jan 1;28(1):27-30 [10592173] Trends Genet. 2002 May;18(5):252-8 [12047950] Science. 2003 Aug 8;301(5634):798-802 [12907790] In Silico Biol. 2003;3(3):235-40 [12954087] Cancer Res. 2004 Feb 1;64(3):1050-7 [14871837] Cancer Res. 2004 Jun 1;64(11):3871-7 [15172996] J Agric Food Chem. 2004 Nov 3;52(22):6830-6 [15506823] CRC Crit Rev Food Sci Nutr. 1979;11(4):355-400 [378551] Carcinogenesis. 1986 May;7(5):689-95 [2870822] Carcinogenesis. 1993 Apr;14(4):551-7 [8472313] Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1361-5 [8108416] IARC Monogr Eval Carcinog Risks Hum. 1995;63:393-407 [9097102] Toxicology. 1997 Mar 28;118(2-3):195-204 [9129173] Cell Mol Life Sci. 1998 Jan;54(1):21-31 [9487384] J Natl Cancer Inst. 1999 Aug 4;91(15):1288-94 [10433617] Biochem Biophys Res Commun. 1999 Sep 7;262(3):624-8 [10471374] Cancer Lett. 2005 Nov 8;229(1):1-11 [16157213] Mutat Res. 2006 Jan 29;593(1-2):80-7 [16144704] J Biol Chem. 2008 Feb 15;283(7):4051-60 [18065415] Nat Protoc. 2008;3(6):1101-8 [18546601] Cancer Invest. 2008 Jul;26(6):575-82 [18584348] Mutat Res. 2008 Jul-Aug;659(1-2):40-8 [18407786] Exp Toxicol Pathol. 2009 Mar;61(2):101-11 [18809303] Methods Mol Biol. 2009;563:379-98 [19597796] Ann Surg Oncol. 2009 Sep;16(9):2555-64 [19548033] Am J Pathol. 2009 Oct;175(4):1653-61 [19717643] Curr Protoc Mol Biol. 2010 Jan;Chapter 21:Unit 21.17.1-16 [20069538] Toxicol Pathol. 2010 Feb;38(2):230-43 [20124500] Cancer Res. 2010 Sep 1;70(17):6968-77 [20713525] Environ Health Perspect. 2010 Nov;118(11):1597-602 [20562052] Nature. 2011 May 5;473(7345):43-9 [21441907] PLoS Genet. 2011 Nov;7(11):e1002376 [22102830] Toxicology. 2012 Feb 26;292(2-3):63-70 [22079235] Free Radic Biol Med. 2012 Feb 15;52(4):735-46 [22206977] J Trace Elem Med Biol. 2012 Jun;26(2-3):174-8 [22633395] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu313 ER - TY - JOUR T1 - A beating heart cell model to predict cardiotoxicity: effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine. AN - 1666293487; 25684415 AB - Some dietary supplements may contain cardiac stimulants and potential cardiotoxins. In vitro studies may identify ingredients of concern. A beating human cardiomyocyte cell line was used to evaluate cellular effects following phenylethylamine (PEA), higenamine, ephedrine or caffeine treatment. PEA and higenamine exposure levels simulated published blood levels in humans or animals after intravenous administration. Ephedrine and caffeine levels approximated published blood levels following human oral intake. At low or midrange levels, each chemical was examined plus or minus 50 µM caffeine, simulating human blood levels reported after consumption of caffeine-enriched dietary supplements. To measure beats per minute (BPM), peak width, etc., rhythmic rise and fall in intracellular calcium levels following 30 min of treatment was examined. Higenamine 31.3 ng/ml or 313 ng/ml significantly increased BPM in an escalating manner. PEA increased BPM at 0.8 and 8 µg/ml, while 80 µg/ml PEA reduced BPM and widened peaks. Ephedrine produced a significant BPM dose response from 0.5 to 5.0 µM. Caffeine increased BPM only at a toxic level of 250 µM. Adding caffeine to PEA or higenamine but not ephedrine further increased BPM. These in vitro results suggest that additional testing may be warranted in vivo to further evaluate these effects. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Calvert, Richard AU - Vohra, Sanah AU - Ferguson, Martine AU - Wiesenfeld, Paddy AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, 8301 Muirkirk Rd., Laurel, MD 20708, USA. Electronic address: richard.calvert@fda.hhs.gov. ; U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, 8301 Muirkirk Rd., Laurel, MD 20708, USA. ; U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Management, Division of Mathematics, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 207 EP - 213 VL - 78 KW - Alkaloids KW - 0 KW - Cardiotonic Agents KW - Phenethylamines KW - Tetrahydroisoquinolines KW - Caffeine KW - 3G6A5W338E KW - Ephedrine KW - GN83C131XS KW - higenamine KW - TBV5O16GAP KW - Index Medicus KW - Higenamine KW - iCell cardiomyocytes KW - Cardiac effects KW - Phenylethylamine KW - Rats KW - Animals KW - Cardiotonic Agents -- toxicity KW - Cardiotoxicity -- pathology KW - Cells, Cultured KW - Humans KW - Toxicity Tests KW - Heart -- drug effects KW - Myocytes, Cardiac -- drug effects KW - Phenethylamines -- toxicity KW - Caffeine -- toxicity KW - Dietary Supplements -- toxicity KW - Alkaloids -- toxicity KW - Ephedrine -- toxicity KW - Tetrahydroisoquinolines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1666293487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=A+beating+heart+cell+model+to+predict+cardiotoxicity%3A+effects+of+the+dietary+supplement+ingredients+higenamine%2C+phenylethylamine%2C+ephedrine+and+caffeine.&rft.au=Calvert%2C+Richard%3BVohra%2C+Sanah%3BFerguson%2C+Martine%3BWiesenfeld%2C+Paddy&rft.aulast=Calvert&rft.aufirst=Richard&rft.date=2015-04-01&rft.volume=78&rft.issue=&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.01.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-17 N1 - Date created - 2015-03-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.01.022 ER - TY - JOUR T1 - Chiral resolution and absolute configuration of the enantiomers of the psychoactive "designer drug" 3,4-methylenedioxypyrovalerone. AN - 1664774469; 25727807 AB - Illicit rac-MDPV (3,4-methylenedioxypyrovalerone), manufactured in clandestine labs, has become widely abused for its cocaine-like stimulant properties. It has recently been found as one of the toxic materials in the so-called "bath salts," producing, among other effects, psychosis and tachycardia in humans when introduced by any of the several routes of administration (e.g., intravenous, oral, etc.). The considerable toxicity of this "designer drug" probably resides in one of the enantiomers of the racemate. In order to obtain a sufficient amount of the enantiomers of rac-MDPV to determine their activity, we improved the known synthesis of rac-MDPV and found chemical resolving agents, (+)- and (-)-2'-bromotetranilic acid, that gave the MDPV enantiomers in >96% enantiomeric excess as determined by (1) H nuclear magnetic resonance and chiral high-performance liquid chromatography. The absolute stereochemistry of these enantiomers was determined by single-crystal X-ray diffraction studies. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Chirality AU - Suzuki, Masaki AU - Deschamps, Jeffrey R AU - Jacobson, Arthur E AU - Rice, Kenner C AD - Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 287 EP - 293 VL - 27 IS - 4 KW - 3,4-methylenedioxypyrovalerone KW - 0 KW - Benzodioxoles KW - Designer Drugs KW - Psychotropic Drugs KW - Pyrrolidines KW - Hydrochloric Acid KW - QTT17582CB KW - Index Medicus KW - euphoric stimulant KW - bath salts KW - designer drug KW - synthesis KW - non-chromatographic chiral resolution KW - 3,4-methylenedioxypyrovalerone (MDPV) KW - Stereoisomerism KW - Hydrochloric Acid -- chemistry KW - Limit of Detection KW - Pyrrolidines -- analysis KW - Psychotropic Drugs -- isolation & purification KW - Designer Drugs -- isolation & purification KW - Psychotropic Drugs -- chemistry KW - Pyrrolidines -- chemistry KW - Benzodioxoles -- isolation & purification KW - Benzodioxoles -- analysis KW - Psychotropic Drugs -- analysis KW - Pyrrolidines -- isolation & purification KW - Benzodioxoles -- chemistry KW - Designer Drugs -- chemistry KW - Designer Drugs -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664774469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chirality&rft.atitle=Chiral+resolution+and+absolute+configuration+of+the+enantiomers+of+the+psychoactive+%22designer+drug%22+3%2C4-methylenedioxypyrovalerone.&rft.au=Suzuki%2C+Masaki%3BDeschamps%2C+Jeffrey+R%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Suzuki&rft.aufirst=Masaki&rft.date=2015-04-01&rft.volume=27&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Chirality&rft.issn=1520-636X&rft_id=info:doi/10.1002%2Fchir.22423 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-30 N1 - Date created - 2015-03-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/chir.22423 ER - TY - JOUR T1 - Analysis of Bacillus cereus toxicity using PCR, ELISA and a lateral flow device. AN - 1664442587; 25627167 AB - The aim of this study was to evaluate the performance of immunodetection methods and PCR analysis of enterotoxigenic Bacillus cereus strains. Eighty-eight enterotoxigenic B. cereus group strains linked to food-borne outbreaks and illnesses were studied with 30 exclusivity nonenterotoxigenic strains including Bacillus amyoliquifaciens, Bacillus subtilis, Staphylococcus aureus, Salmonella and Escherichia coli for this assessment. The PCR results showed 80% agreement with immunoassays for the Nhe target and 84% for the Hbl product. All exclusivity strains were PCR and serologically negative. PCR has proven to be a valuable tool when used in conjunction with immunoassays to quickly identify enterotoxigenic B. cereus group strains. This study assessed the utility of rapid methods to characterize enterotoxigenic profiles of B. cereus group strains. The identification of enterotoxigenic bacteria and any associated toxins detected from food products is essential in food defense programs as public health officials search for methods to rapidly and accurately screen a global food supply. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied microbiology AU - Tallent, S M AU - Hait, J M AU - Bennett, R W AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 1068 EP - 1075 VL - 118 IS - 4 KW - Bacterial Proteins KW - 0 KW - Bacterial Toxins KW - Enterotoxins KW - Hemolysin Proteins KW - NheA protein, Bacillus cereus KW - enterotoxin, Bacillus cereus KW - hemolysin BL protein, Bacillus KW - Index Medicus KW - food-borne illness KW - detection KW - food poisoning KW - enterotoxigenic KW - Bacillus cereus KW - Bacterial Toxins -- genetics KW - Bacterial Proteins -- genetics KW - Bacterial Toxins -- analysis KW - Hemolysin Proteins -- analysis KW - Humans KW - Hemolysin Proteins -- genetics KW - Bacterial Proteins -- analysis KW - Enterotoxins -- genetics KW - Bacillus -- genetics KW - Polymerase Chain Reaction KW - Food Microbiology KW - Enzyme-Linked Immunosorbent Assay KW - Bacillus cereus -- genetics KW - Bacillus cereus -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664442587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+microbiology&rft.atitle=Analysis+of+Bacillus+cereus+toxicity+using+PCR%2C+ELISA+and+a+lateral+flow+device.&rft.au=Tallent%2C+S+M%3BHait%2C+J+M%3BBennett%2C+R+W&rft.aulast=Tallent&rft.aufirst=S&rft.date=2015-04-01&rft.volume=118&rft.issue=4&rft.spage=1068&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+microbiology&rft.issn=1365-2672&rft_id=info:doi/10.1111%2Fjam.12766 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-30 N1 - Date created - 2015-03-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/jam.12766 ER - TY - JOUR T1 - The role for microRNAs in drug toxicity and in safety assessment. AN - 1664205450; 25739314 AB - Adverse drug reactions present significant challenges that impact pharmaceutical development and are major burdens to public health services worldwide. In response to this need, the field of toxicology is rapidly expanding to identify key pathways involved in drug toxicity. MicroRNAs (miRNAs) are a class of small evolutionary conserved endogenous non-coding RNAs that regulate the translation of protein-coding genes. A wide range of toxicants alter miRNA levels in target organs and these altered miRNAs can also be detected in easily accessible biological fluids. This, combined with an early miRNA response to toxic insults and miRNA stability, substantiates the potential for these small molecules to be useful biomarkers for drug safety assessment. miRNAs are early indicators and useful tools to detect drug-induced toxicity. Incorporation of miRNA profiling into the drug safety testing process will complement currently used techniques and may substantially enhance drug safety. With the increasing interests in translational research, the field of miRNA biomarker research will continue to expand and become an important part of the investigation of human drug toxicity. JF - Expert opinion on drug metabolism & toxicology AU - Marrone, April K AU - Beland, Frederick A AU - Pogribny, Igor P AD - FDA-National Center for Toxicological Research, Division of Biochemical Toxicology , Jefferson, AR , USA igor.pogribny@fda.hhs.gov. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 601 EP - 611 VL - 11 IS - 4 KW - Biomarkers KW - 0 KW - MicroRNAs KW - Index Medicus KW - drug toxicity KW - adverse drug reactions KW - microRNAs KW - safety assessment KW - Animals KW - Public Health KW - Humans KW - Toxicity Tests -- methods KW - Translational Medical Research -- trends KW - Risk Assessment -- methods KW - Drug Design KW - MicroRNAs -- genetics KW - Drug-Related Side Effects and Adverse Reactions -- genetics KW - Biomarkers -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664205450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=The+role+for+microRNAs+in+drug+toxicity+and+in+safety+assessment.&rft.au=Marrone%2C+April+K%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Marrone&rft.aufirst=April&rft.date=2015-04-01&rft.volume=11&rft.issue=4&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/10.1517%2F17425255.2015.1021687 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-23 N1 - Date created - 2015-03-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1517/17425255.2015.1021687 ER - TY - JOUR T1 - Prediction of drug clearance in children: a review of different methodologies. AN - 1664204526; 25740388 AB - Children are not small adults because the differences between adults and children are not simply due to body weight, but also due to physiological and biochemical differences. Hence, dosing in children should not be a 'small adult dose'. During pediatric drug development, selection of a suitable dose for the first-in-children clinical study (Pharmacokinetic [PK], safety and efficacy) is of utmost importance. Considering the importance of clearance in dose selection, a lot of approaches have been suggested for the prediction of drug clearance in children. This review examines many proposed methods for the prediction of drug clearance in the pediatric population and highlights the application and limitations of these proposed methods. In this review, different methods for the prediction of drug clearance in the pediatric population are discussed. These methods include allometric models, population-based pharmacometric models and physiologically based PK models. All models discussed here have uncertainties in their predictive power and should be only used as exploratory tools during pediatric drug development. Allometric models, if used with knowledge and understanding, is a powerful tool for the prediction of drug clearance in pediatric population. JF - Expert opinion on drug metabolism & toxicology AU - Mahmood, Iftekhar AD - Center for Biologic Evaluation and Research, Office of Blood Review and Research (OBRR), Division of Hematology, US Food and Drug Administration , Silver Spring, MD , USA +1 301 402 8418 ; Iftekhar.mahmood@fda.hhs.gov. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 573 EP - 587 VL - 11 IS - 4 KW - Index Medicus KW - population-based pharmacometric models KW - physiological models KW - allometric models KW - drug clearance KW - children KW - Animals KW - Age Factors KW - Dose-Response Relationship, Drug KW - Humans KW - Adult KW - Child KW - Models, Biological KW - Drug Design KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664204526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.atitle=Prediction+of+drug+clearance+in+children%3A+a+review+of+different+methodologies.&rft.au=Mahmood%2C+Iftekhar&rft.aulast=Mahmood&rft.aufirst=Iftekhar&rft.date=2015-04-01&rft.volume=11&rft.issue=4&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+drug+metabolism+%26+toxicology&rft.issn=1744-7607&rft_id=info:doi/10.1517%2F17425255.2015.1019463 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-23 N1 - Date created - 2015-03-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1517/17425255.2015.1019463 ER - TY - JOUR T1 - Water management decision makers' evaluations of uncertainty in a decision support system: the case of WaterSim in the decision theater AN - 1663902207; 4654427 AB - Model-based decision support systems are increasingly used to link knowledge to action for environmental decision making. How stakeholders perceive uncertainty in models and visualisations affects their perceptions of credibility, relevance and usability of these tools. This paper presents a case study of water decision makers' evaluations of WaterSim, a dynamic water simulation model presented in an immersive decision theatre environment. Results reveal that decision makers' understandings of uncertainty in their evaluations of decision support systems reflect both scientific and political discourse. We conclude with recommendations for design and evaluation of decision support systems that incorporate decision makers' views. Reprinted by permission of Carfax Publishing, Taylor & Francis Ltd. JF - Journal of environmental planning and management AU - White, Dave D AU - Wutich, Amber Y AU - Larson, Kelli L AU - Lant, Tim AD - Arizona State University ; US Department of Health and Human Services Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 616 EP - 630 VL - 58 IS - 4 SN - 0964-0568, 0964-0568 KW - Economics KW - U.S.A. KW - Uncertainty KW - Decision making KW - Stakeholder KW - Water management KW - Arizona KW - Climate change KW - Modelling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1663902207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+planning+and+management&rft.atitle=Water+management+decision+makers%27+evaluations+of+uncertainty+in+a+decision+support+system%3A+the+case+of+WaterSim+in+the+decision+theater&rft.au=White%2C+Dave+D%3BWutich%2C+Amber+Y%3BLarson%2C+Kelli+L%3BLant%2C+Tim&rft.aulast=White&rft.aufirst=Dave&rft.date=2015-04-01&rft.volume=58&rft.issue=4&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+planning+and+management&rft.issn=09640568&rft_id=info:doi/10.1080%2F09640568.2013.875892 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-03-16 N1 - Last updated - 2015-03-17 N1 - SubjectsTermNotLitGenreText - 2382 2381 8560 9511 4309 4313; 8162 8163; 13472 7625; 3322 6071 1542 11325; 13078; 12158; 25 433 293 14 DO - http://dx.doi.org/10.1080/09640568.2013.875892 ER - TY - JOUR T1 - Prescription opioids. III. Disposition of oxycodone in oral fluid and blood following controlled single-dose administration. AN - 1663899164; 25589778 AB - Oxycodone (OC) is recommended to be included as an analyte tested in the proposed Substance Abuse and Mental Health Services Administration (SAMHSA's) Mandatory Guidelines for Federal Workplace Drug Testing Programs using Oral Fluid (OF) Specimens. This study demonstrates the time course of OC and metabolites, noroxycodone (NOC), oxymorphone (OM) and noroxymorphone (NOM), in near-simultaneous paired OF and whole blood (BL) specimens by liquid chromatography-tandem mass spectrometry (LC-MS-MS) (limit of detection = 1 ng/mL OF, 5 ng/mL BL). A single dose of OC 20 mg controlled-release was administered to 12 healthy subjects followed by specimen collections for 52 h. Analyte prevalence was as follows: OF, OC > NOC > OM; and BL, OC > NOC > NOM. OC and NOC were frequently detected within 15-30 min in OF and 30 min to 2 h in BL. NOM and OM appeared between 1.5-5 h post-dose. The mean OF-to-BL (OF:BL) ratios and correlations were 5.4 for OC (r = 0.719) and 1.0 for NOC (r = 0.651). The period of detection for OF exceeded BL by ∼2-fold at similar cutoff concentrations. At a 1 ng/mL cutoff for OF, the mean detection time was 34 h for OC and NOC. These data provide new information that should facilitate interpretation of OC test results. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Journal of analytical toxicology AU - Cone, Edward J AU - DePriest, Anne Z AU - Heltsley, Rebecca AU - Black, David L AU - Mitchell, John M AU - LoDico, Charles AU - Flegel, Ron AD - Johns Hopkins School of Medicine, Baltimore, MD, USA. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA anne.depriest@aegislabs.com. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA. ; RTI International, Research Triangle Park, NC, USA. ; Division of Workplace Programs (DWP), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 192 EP - 202 VL - 39 IS - 3 KW - Analgesics, Opioid KW - 0 KW - Delayed-Action Preparations KW - Prescription Drugs KW - Oxycodone KW - CD35PMG570 KW - Index Medicus KW - Administration, Oral KW - Occupational Health KW - Drug Administration Schedule KW - Biotransformation KW - Humans KW - Chromatography, Liquid KW - Workplace KW - Tissue Distribution KW - Tandem Mass Spectrometry KW - Oxycodone -- blood KW - Analgesics, Opioid -- blood KW - Prescription Drugs -- administration & dosage KW - Saliva -- chemistry KW - Oxycodone -- pharmacokinetics KW - Oxycodone -- administration & dosage KW - Analgesics, Opioid -- pharmacokinetics KW - Prescription Drugs -- pharmacokinetics KW - Analgesics, Opioid -- administration & dosage KW - Prescription Drugs -- analysis KW - Substance Abuse Detection -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1663899164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Prescription+opioids.+III.+Disposition+of+oxycodone+in+oral+fluid+and+blood+following+controlled+single-dose+administration.&rft.au=Cone%2C+Edward+J%3BDePriest%2C+Anne+Z%3BHeltsley%2C+Rebecca%3BBlack%2C+David+L%3BMitchell%2C+John+M%3BLoDico%2C+Charles%3BFlegel%2C+Ron&rft.aulast=Cone&rft.aufirst=Edward&rft.date=2015-04-01&rft.volume=39&rft.issue=3&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbku176 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-03 N1 - Date created - 2015-03-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bku176 ER - TY - JOUR T1 - Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes. AN - 1662638218; 25510677 AB - Multi-walled carbon nanotubes (MWCNT) are new materials with a wide range of industrial and commercial applications. However, their nano-scaled size and fiber-like shape render them respirable and potentially fibrogenic if inhaled into the lungs. To understand MWCNT fibrogenesis, we analyzed the pathologic and molecular aspects of the early phase response to MWCNT in mouse lungs. MWCNT induced rapid and pronounced lesions in the lungs characterized by increased cellularity and formation of fibrotic foci, most notably near where MWCNT deposited, within 14 days post-exposure. Deposition of collagen fibers was markedly increased in the alveolar septa and fibrotic foci, accompanied by elevated expression of fibrotic genes Col1a1, Col1a2, and Fn1 at both mRNA and protein levels. Fibrosis was induced rapidly at 40 μg, wherein fibrotic changes were detected on day 1 and reached a maximal intensity on day 7 through day 14. Induction of fibrosis was dose-dependent at the dose range of 5-40 μg, 7 days post-exposure. MWCNT elicited rapid and prominent infiltrations of neutrophils and macrophages alongside fibrosis implicating acute inflammation in the fibrotic response. At the molecular level, MWCNT induced elevated expression of proinflammatory cytokines TNFα, IL1α, IL1β, IL6, and CCL2 in lung tissues as well as the bronchoalveolar lavage fluid, in a dose- and time-dependent manner. MWCNT also increased the expression of fibrogenic growth factors TGF-β1 and PDGF-A in the lungs significantly. These findings underscore the interplay between acute inflammation and the early fibrotic response in the initiation and propagation of pulmonary fibrosis induced by MWCNT. JF - Archives of toxicology AU - Dong, Jie AU - Porter, Dale W AU - Batteli, Lori A AU - Wolfarth, Michael G AU - Richardson, Diana L AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV, 26505, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 621 EP - 633 VL - 89 IS - 4 KW - Collagen Type I KW - 0 KW - Cytokines KW - Fibronectins KW - Nanotubes, Carbon KW - alpha 2(I) collagen KW - collagen type I, alpha 1 chain KW - Index Medicus KW - Cytokines -- analysis KW - Animals KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Mice, Inbred C57BL KW - Fibronectins -- genetics KW - Collagen Type I -- genetics KW - Time Factors KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Lung -- immunology KW - Pulmonary Fibrosis -- immunology KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Lung -- drug effects KW - Lung -- pathology KW - Lung -- metabolism KW - Nanotubes, Carbon -- toxicity KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1662638218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Pathologic+and+molecular+profiling+of+rapid-onset+fibrosis+and+inflammation+induced+by+multi-walled+carbon+nanotubes.&rft.au=Dong%2C+Jie%3BPorter%2C+Dale+W%3BBatteli%2C+Lori+A%3BWolfarth%2C+Michael+G%3BRichardson%2C+Diana+L%3BMa%2C+Qiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2015-04-01&rft.volume=89&rft.issue=4&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-014-1428-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-14 N1 - Date created - 2015-03-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00204-014-1428-y ER - TY - JOUR T1 - Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress. AN - 1661994566; 25301065 AB - Dual control of cellular heme levels by extracellular scavenger proteins and degradation by heme oxygenases is essential in diseases associated with increased heme release. During severe hemolysis or rhabdomyolysis, uncontrolled heme exposure can cause acute kidney injury and endothelial cell damage. The toxicity of heme was primarily attributed to its pro-oxidant effects; however additional mechanisms of heme toxicity have not been studied systematically. In addition to redox reactivity, heme may adversely alter cellular functions by binding to essential proteins and impairing their function. We studied inducible heme oxygenase (Hmox1)-deficient mouse embryo fibroblast cell lines as a model to systematically explore adaptive and disruptive responses that were triggered by intracellular heme levels exceeding the homeostatic range. We extensively characterized the proteome phenotype of the cellular heme stress responses by quantitative mass spectrometry of stable isotope-labeled cells that covered more than 2000 individual proteins. The most significant signals specific to heme toxicity were consistent with oxidative stress and impaired protein degradation by the proteasome. This ultimately led to an activation of the response to unfolded proteins. These observations were explained mechanistically by demonstrating binding of heme to the proteasome that was linked to impaired proteasome function. Oxidative heme reactions and proteasome inhibition could be differentiated as synergistic activities of the porphyrin. Based on the present data a novel model of cellular heme toxicity is proposed, whereby proteasome inhibition by heme sustains a cycle of oxidative stress, protein modification, accumulation of damaged proteins and cell death. JF - Cell death and differentiation AU - Vallelian, F AU - Deuel, J W AU - Opitz, L AU - Schaer, C A AU - Puglia, M AU - Lönn, M AU - Engelsberger, W AU - Schauer, S AU - Karnaukhova, E AU - Spahn, D R AU - Stocker, R AU - Buehler, P W AU - Schaer, D J AD - Division of Internal Medicine, University of Zurich, CH-8091 Zurich, Switzerland. ; Functional Genomics Center Zurich, Swiss Federal Institute of Technology Zurich/University of Zurich, Zurich, Switzerland. ; 1] Division of Internal Medicine, University of Zurich, CH-8091 Zurich, Switzerland [2] Institute of Anesthesiology, University of Zurich, Zurich, Switzerland. ; 1] Division of Internal Medicine, University of Zurich, CH-8091 Zurich, Switzerland [2] Functional Genomics Center Zurich, Swiss Federal Institute of Technology Zurich/University of Zurich, Zurich, Switzerland. ; School of Medical Sciences, Discipline of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia. ; Laboratory of Biochemistry and Vascular Biology, Center of Biologics Evaluation and Research (CBER), FDA, Bethesda, MD, USA. ; Institute of Anesthesiology, University of Zurich, Zurich, Switzerland. ; 1] School of Medical Sciences, Discipline of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia [2] Victor Chang Cardiac Research Institute and University of New South Wales, Sydney, New South Wales, Australia. ; 1] Division of Internal Medicine, University of Zurich, CH-8091 Zurich, Switzerland [2] Center of Evolutionary Medicine, University of Zurich, Zurich, Switzerland. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 597 EP - 611 VL - 22 IS - 4 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Heat-Shock Proteins KW - Membrane Proteins KW - Proteasome Inhibitors KW - Sequestosome-1 Protein KW - Sqstm1 protein, mouse KW - Ubiquitin KW - Heme KW - 42VZT0U6YR KW - Bortezomib KW - 69G8BD63PP KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Hmox1 protein, mouse KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Animals KW - Proteasome Inhibitors -- pharmacology KW - Membrane Proteins -- metabolism KW - HEK293 Cells KW - Humans KW - Bortezomib -- pharmacology KW - Spectrophotometry, Ultraviolet KW - Circular Dichroism KW - Mice KW - Heme Oxygenase-1 -- genetics KW - Membrane Proteins -- genetics KW - Mice, Inbred BALB C KW - Protein Binding KW - Mice, Knockout KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Ubiquitin -- metabolism KW - Cell Survival -- drug effects KW - Heme Oxygenase-1 -- metabolism KW - Cell Line KW - Proteasome Endopeptidase Complex -- metabolism KW - Proteasome Endopeptidase Complex -- chemistry KW - Oxidative Stress -- drug effects KW - Heme -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1661994566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+death+and+differentiation&rft.atitle=Proteasome+inhibition+and+oxidative+reactions+disrupt+cellular+homeostasis+during+heme+stress.&rft.au=Vallelian%2C+F%3BDeuel%2C+J+W%3BOpitz%2C+L%3BSchaer%2C+C+A%3BPuglia%2C+M%3BL%C3%B6nn%2C+M%3BEngelsberger%2C+W%3BSchauer%2C+S%3BKarnaukhova%2C+E%3BSpahn%2C+D+R%3BStocker%2C+R%3BBuehler%2C+P+W%3BSchaer%2C+D+J&rft.aulast=Vallelian&rft.aufirst=F&rft.date=2015-04-01&rft.volume=22&rft.issue=4&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Cell+death+and+differentiation&rft.issn=1476-5403&rft_id=info:doi/10.1038%2Fcdd.2014.154 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-25 N1 - Date created - 2015-03-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Pharmacol Rev. 2008 Mar;60(1):79-127 [18323402] Biol Chem. 2008 Mar;389(3):203-9 [18208355] J Proteome Res. 2010 Aug 6;9(8):4061-70 [20568812] Trends Mol Med. 2010 Oct;16(10):447-57 [20708968] Blood. 2010 Dec 9;116(24):5347-56 [20739658] Antioxid Redox Signal. 2011 Oct 15;15(8):2265-99 [21314436] Blood. 2012 Mar 8;119(10):2368-75 [22262768] Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1394-409 [22245770] J Neuroinflammation. 2012;9:46 [22394415] J Am Chem Soc. 2012 Jun 27;134(25):10451-7 [22642538] Blood. 2013 Feb 21;121(8):1276-84 [23264591] Cold Spring Harb Perspect Med. 2013 Jun;3(6). pii: a013433. doi: 10.1101/cshperspect.a013433 [23645855] Cell Death Differ. 2013 Nov;20(11):1569-79 [23995229] Antioxid Redox Signal. 2013 Nov 10;19(14):1619-33 [23418677] J Clin Invest. 2013 Nov;123(11):4809-20 [24084741] J Proteomics. 2014 Apr 4;100:147-59 [24200835] Mol Cell Proteomics. 2002 May;1(5):376-86 [12118079] Blood. 2002 Aug 1;100(3):879-87 [12130498] Biochem J. 1979 May 1;179(2):281-9 [486081] Eur J Biochem. 1990 Jul 31;191(2):275-80 [2200671] Trans Assoc Am Physicians. 1990;103:174-9 [2132529] Eur J Biochem. 1992 Jun 1;206(2):567-78 [1317798] J Clin Invest. 1992 Jul;90(1):267-70 [1634613] Trans Assoc Am Physicians. 1992;105:1-6 [1308986] Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9285-9 [8415693] J Biol Chem. 1996 Dec 20;271(51):32538-45 [8955078] J Cell Biol. 1998 Dec 28;143(7):1883-98 [9864362] J Clin Invest. 1999 Jan;103(1):129-35 [9884342] J Biol Chem. 1999 Jan 29;274(5):2616-24 [9915789] J Cell Sci. 2006 Jan 15;119(Pt 2):303-13 [16390870] FASEB J. 2006 Mar;20(3):562-4 [16410344] Biochim Biophys Acta. 2006 Sep;1762(9):819-27 [16935474] J Leukoc Biol. 2008 Feb;83(2):325-33 [17947394] J Clin Invest. 2009 Aug;119(8):2271-80 [19620788] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/cdd.2014.154 ER - TY - JOUR T1 - The impact of recent cocaine use on plasma levels of methadone and buprenorphine in patients with and without HIV-infection. AN - 1660437527; 25480096 AB - Cocaine decreases methadone and buprenorphine plasma concentrations. HIV infection and/or antiretroviral medication use may impact these relationships. We sought to determine the association between recent cocaine use and methadone and buprenorphine concentrations in HIV-infected and uninfected subjects in clinical care. R- and S-methadone or buprenorphine and norbuprenorphine concentrations were assessed at 0.5, 1, 2, and 24 hours after dosing in subjects with confirmed cocaine use and abstinence. We compared methadone and buprenorphine concentrations for cocaine use vs. abstinence, by HIV status in 16 subjects receiving methadone (6 HIV-infected) and 17 receiving buprenorphine (8 HIV-infected). With recent cocaine use, peak R-methadone (244 vs. 297 ng/mL, p = 0.03) and peak S-methadone (285 vs. 339 ng/mL); p = 0.03 concentrations were lower in HIV-uninfected subjects only. Peak buprenorphine and norbuprenorphine concentrations were unchanged regardless of cocaine use or HIV status. Cocaine may decrease methadone concentrations in HIV-uninfected subjects. HIV infection or its treatment may attenuate cocaine's effect on methadone. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Journal of substance abuse treatment AU - Tetrault, Jeanette M AU - McCance-Katz, Elinore F AU - Moody, David E AU - Fiellin, David A AU - Lruie, Bonnie S AU - DInh, An T AU - Fiellin, Lynn E AD - Department of Internal Medicine. Yale University School of Medicine, New Haven, CT, USA. Electronic address: jeanette.tetrault@yale.edu. ; Substance Abuse and Mental Health Services Administration, Rockville, MD, USA. ; Center for Human Toxicology, University of Utah, Salt Lake City, UT, USA. ; Department of Internal Medicine. Yale University School of Medicine, New Haven, CT, USA; Center for Interdisciplinary Research on AIDS, Yale University School of Public Health, New Haven, CT, USA; Investigative Medicine Program, Yale University School of Medicine, New Haven, CT, USA. ; Department of Internal Medicine. Yale University School of Medicine, New Haven, CT, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 70 EP - 74 VL - 51 KW - Anti-HIV Agents KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - norbuprenorphine KW - 7E53B4O073 KW - Cocaine KW - I5Y540LHVR KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Stereoisomerism KW - Drug Interactions KW - Anti-HIV Agents -- therapeutic use KW - Humans KW - Adult KW - Opiate Substitution Treatment -- methods KW - Opioid-Related Disorders -- rehabilitation KW - Middle Aged KW - Time Factors KW - Cocaine -- administration & dosage KW - Male KW - Female KW - HIV Infections -- complications KW - Methadone -- chemistry KW - Buprenorphine -- pharmacokinetics KW - HIV Infections -- drug therapy KW - Methadone -- pharmacokinetics KW - Buprenorphine -- administration & dosage KW - Methadone -- administration & dosage KW - Buprenorphine -- analogs & derivatives KW - Cocaine-Related Disorders -- complications KW - Buprenorphine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660437527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=The+impact+of+recent+cocaine+use+on+plasma+levels+of+methadone+and+buprenorphine+in+patients+with+and+without+HIV-infection.&rft.au=Tetrault%2C+Jeanette+M%3BMcCance-Katz%2C+Elinore+F%3BMoody%2C+David+E%3BFiellin%2C+David+A%3BLruie%2C+Bonnie+S%3BDInh%2C+An+T%3BFiellin%2C+Lynn+E&rft.aulast=Tetrault&rft.aufirst=Jeanette&rft.date=2015-04-01&rft.volume=51&rft.issue=&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=1873-6483&rft_id=info:doi/10.1016%2Fj.jsat.2014.10.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-01 N1 - Date created - 2015-03-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jsat.2014.10.010 ER - TY - JOUR T1 - Comparison of eight different agars for the recovery of clinically relevant non-O157 Shiga toxin-producing Escherichia coli from baby spinach, cilantro, alfalfa sprouts and raw milk AN - 1647018857; 21290782 AB - The FDA Bacteriological Analytical Manual (BAM) Chapter 4a recommends several agars for isolating non-O157 Shiga toxin-producing Escherichia coli (STEC); not all have been thoroughly tested for recovering STECs from food. Using E. coli strains representing ten clinically relevant O serogroups (O26, O45, O91, O103, O104, O111, O113, O121, O128, O145) in artificially-contaminated fresh produce - bagged baby spinach, alfalfa sprouts, cilantro, and raw milk - we evaluated the performance of 8 different agars. Performance was highly dependent upon strain used and the presence of inhibitors, but not necessarily dependent on food matrix. Tellurite resistant-negative strains, O91:-, O103:H6, O104:H21, O113:H21, and O128, grew poorly on CHROMagar STEC, Rainbow agar O157, and a modified Rainbow O157 (mRB) agar. Although adding washed sheep's blood to CHROMagar STEC and mRB agars improved overall performance; however, this also reversed the inhibition of non-target bacteria provided by original formulations. Variable colony coloration made selecting colonies from Rainbow agar O157 and mRB agars difficult. Study results support a strategy using inclusive agars (e.g. L-EMB, SHIBAM) in combination with selective agars (R & F E. coli O157:H7, CHROMagar STEC) to allow for recovery of the most STECs while increasing the probability of recovering STEC in high bacterial count matrices. JF - Food Microbiology AU - Kase, Julie A AU - Maounounen-Laasri, Anna AU - Son, Insook AU - Lin, Andrew AU - Hammack, Thomas S AD - Division of Microbiology, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, College Park, MD 20740, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 280 EP - 287 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacteriological agar KW - STEC KW - Fresh produce KW - Raw milk KW - Agar KW - Blood KW - Colonies KW - Milk KW - Coloration KW - Food KW - Escherichia coli KW - tellurite KW - Spinacia oleracea KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647018857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Comparison+of+eight+different+agars+for+the+recovery+of+clinically+relevant+non-O157+Shiga+toxin-producing+Escherichia+coli+from+baby+spinach%2C+cilantro%2C+alfalfa+sprouts+and+raw+milk&rft.au=Kase%2C+Julie+A%3BMaounounen-Laasri%2C+Anna%3BSon%2C+Insook%3BLin%2C+Andrew%3BHammack%2C+Thomas+S&rft.aulast=Kase&rft.aufirst=Julie&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.08.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Blood; Agar; Colonies; Coloration; Milk; Food; tellurite; Escherichia coli; Spinacia oleracea DO - http://dx.doi.org/10.1016/j.fm.2014.08.020 ER - TY - JOUR T1 - Evaluation and comparison of rapid methods for the detection of Salmonella in naturally contaminated pine nuts using different pre enrichment media AN - 1647018841; 21290767 AB - Foodborne outbreaks, involving pine nuts and peanut butter, illustrate the need to rapidly detect Salmonella in low moisture foods. However, the current Bacteriological Analytical Manual (BAM) culture method for Salmonella, using lactose broth (LB) as a pre enrichment medium, has not reliably supported real-time quantitative PCR (qPCR) assays for certain foods. We evaluated two qPCR assays in LB and four other pre enrichment media: buffered peptone water (BPW), modified BPW (mBPW), Universal Pre enrichment broth (UPB), and BAX registered MP media to detect Salmonella in naturally-contaminated pine nuts (2011 outbreak). A four-way comparison among culture method, Pathatrix registered Auto, VIDAS registered Easy SLM, and qPCR was conducted. Automated DNA extraction techniques were compared with manual extraction methods (boiling or InstaGene(TM)). There were no significant differences (P > 0.05) among the five pre enrichment media for pine nuts using the culture method. While both qPCR assays produced significantly (P less than or equal to 0.05) higher false negatives in 24 h pre enriched LB than in the other four media, they were as sensitive as the culture method in BPW, mBPW, UPB, and BAX media. The VIDAS Easy and qPCR were equivalent; Pathatrix was the least effective method. The Automatic PrepSEQ(TM) DNA extraction, using 1000 mu L of pre enrichment, was as effective as manual extraction methods. JF - Food Microbiology AU - Wang, Hua AU - Gill, Vikas S AU - Cheng, Chorng-Ming AU - Gonzalez-Escalona, Narjol AU - Irvin, Kari A AU - Zheng, Jie AU - Bell, Rebecca L AU - Jacobson, Andrew P AU - Hammack, Thomas S AD - FDA-Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 58 EP - 65 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salmonella KW - Pre enrichment media KW - qPCR KW - Pathatrix registered Auto KW - VIDAS registered Easy KW - DNA extraction KW - PrepSEQ(TM) KW - Pine nuts KW - Arachis hypogaea KW - Peanut butter KW - Lactose KW - Food KW - Media (enrichment) KW - Nuts KW - Boiling KW - Bax protein KW - peptone KW - Polymerase chain reaction KW - Media (culture) KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647018841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Evaluation+and+comparison+of+rapid+methods+for+the+detection+of+Salmonella+in+naturally+contaminated+pine+nuts+using+different+pre+enrichment+media&rft.au=Wang%2C+Hua%3BGill%2C+Vikas+S%3BCheng%2C+Chorng-Ming%3BGonzalez-Escalona%2C+Narjol%3BIrvin%2C+Kari+A%3BZheng%2C+Jie%3BBell%2C+Rebecca+L%3BJacobson%2C+Andrew+P%3BHammack%2C+Thomas+S&rft.aulast=Wang&rft.aufirst=Hua&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.06.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Lactose; Peanut butter; Boiling; peptone; Bax protein; Food; Media (enrichment); Polymerase chain reaction; Nuts; Media (culture); Arachis hypogaea; Salmonella DO - http://dx.doi.org/10.1016/j.fm.2014.06.028 ER - TY - JOUR T1 - Effect of Listeria seeligeri or Listeria welshimeri on Listeria monocytogenes detection in and recovery from buffered Listeria enrichment broth AN - 1647015028; 21290796 AB - The presence of multiple species of Listeria in regulated food products is not uncommon and can complicate the recovery of Listeria monocytogenes particularly on a non-differentiating medium. The potential complications of Listeria seeligeri and Listeria welshimeri on the recovery of L. monocytogenes from inoculated food test samples using the U.S. Food and Drug Administration's (FDA) selective enrichment procedure was investigated. Post-enrichment enumeration, in the absence of food product, indicates that some L. seeligeri and L. monocytogenes pairings may have population differentials as great as 2.7 plus or minus 0.1 logs with L. seeligeri being the predominant species. A similar observation was noted for L. welshimeri and L. monocytogenes pairings which resulted in population differentials as large as 3.7 plus or minus 0.2 logs with L. welshimeri being the predominant species. Select strain pairings were used to inoculate guacamole, crab meat, broccoli, and cheese with subsequent recovery by the FDA Bacteriological Analytical Manual (BAM) method with 10 colonies per sample selected for confirmation. The presence of L. seeligeri had little effect on the recovery of L. monocytogenes. The presence of L. welshimeri resulted in the failure to recover L. monocytogenes in three out of the four food matrices. This work extends the observation that non-pathogenic species of Listeria can complicate the recovery of L. monocytogenes and that competition during selective enrichment is not limited to the presence of just Listeria innocua. JF - Food Microbiology AU - Dailey, Rachel C AU - Welch, Lacinda J AU - Hitchins, Anthony D AU - Smiley, RDerike AD - U.S. Food and Drug Administration, Arkansas Regional Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 528 EP - 534 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Regulatory microbiology KW - Foodborne pathogen KW - Microbial competition KW - Real-time PCR KW - Immunofluorescence assay KW - Lateral flow device KW - Analytical microbiology KW - Selective enrichment KW - Listeria KW - Listeria seeligeri KW - Meat KW - Listeria monocytogenes KW - Colonies KW - Decapoda KW - Listeria welshimeri KW - Listeria innocua KW - Cheese KW - Brassica KW - Competition KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647015028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Effect+of+Listeria+seeligeri+or+Listeria+welshimeri+on+Listeria+monocytogenes+detection+in+and+recovery+from+buffered+Listeria+enrichment+broth&rft.au=Dailey%2C+Rachel+C%3BWelch%2C+Lacinda+J%3BHitchins%2C+Anthony+D%3BSmiley%2C+RDerike&rft.aulast=Dailey&rft.aufirst=Rachel&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.09.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Meat; Colonies; Cheese; Competition; Listeria seeligeri; Listeria monocytogenes; Decapoda; Listeria welshimeri; Listeria innocua; Brassica DO - http://dx.doi.org/10.1016/j.fm.2014.09.008 ER - TY - JOUR T1 - Magnetic bead based immuno-detection of Listeria monocytogenes and Listeria ivanovii from infant formula and leafy green vegetables using the Bio-Plex suspension array system AN - 1647014969; 21290797 AB - Listeriosis, a disease contracted via the consumption of foods contaminated with pathogenic Listeria species, can produce severe symptoms and high mortality in susceptible people and animals. The development of molecular methods and immuno-based techniques for detection of pathogenic Listeria in foods has been challenging due to the presence of assay inhibiting food components. In this study, we utilize a macrophage cell culture system for the isolation and enrichment of Listeria monocytogenes and Listeria ivanovii from infant formula and leafy green vegetables for subsequent identification using the Luminex xMAP technique. Macrophage monolayers were exposed to infant formula, lettuce and celery contaminated with L. monocytogenes or L. ivanovii. Magnetic microspheres conjugated to Listeria specific antibody were used to capture Listeria from infected macrophages and then analyzed using the Bio-Plex 200 analyzer. As few as 10 CFU/mL or g of L. monocytogenes was detected in all foods tested. The detection limit for L. ivanovii was 10 CFU/mL in infant formula and 100 CFU/g in leafy greens. Microsphere bound Listeria obtained from infected macrophage lysates could also be isolated on selective media for subsequent confirmatory identification. This method presumptively identifies L. monocytogenes and L. ivanovii from infant formula, lettuce and celery in less than 28 h with confirmatory identifications completed in less than 48 h. JF - Food Microbiology AU - Day, J B AU - Basavanna, U AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA PY - 2015 SP - 564 EP - 572 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Listeria KW - Detection KW - Foods KW - Macrophage KW - Bio-Plex KW - Macrophages KW - Listeria monocytogenes KW - Mortality KW - Vegetables KW - Infant formulas KW - Listeriosis KW - Food KW - Cell culture KW - Food contamination KW - Media (selective) KW - Food consumption KW - Antibodies KW - Colony-forming cells KW - Listeria ivanovii KW - microspheres KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647014969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Magnetic+bead+based+immuno-detection+of+Listeria+monocytogenes+and+Listeria+ivanovii+from+infant+formula+and+leafy+green+vegetables+using+the+Bio-Plex+suspension+array+system&rft.au=Day%2C+J+B%3BBasavanna%2C+U&rft.aulast=Day&rft.aufirst=J&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.09.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Macrophages; Mortality; Infant formulas; Vegetables; Listeriosis; Food; Cell culture; Food contamination; Media (selective); Food consumption; Antibodies; Colony-forming cells; microspheres; Listeria monocytogenes; Listeria ivanovii DO - http://dx.doi.org/10.1016/j.fm.2014.09.020 ER - TY - JOUR T1 - Cleaning and sanitation of Salmonella-contaminated peanut butter processing equipment AN - 1647014758; 21290762 AB - Microbial contamination of peanut butter by Salmonella poses a significant health risk as Salmonella may remain viable throughout the product shelf life. Effective cleaning and sanitation of processing lines are essential for preventing cross-contamination. The objective of this study was to evaluate the efficacy of a cleaning and sanitation procedure involving hot oil and 60% isopropanol, plus or minus quaternary ammonium compounds, to decontaminate pilot-scale processing equipment harboring Salmonella. Peanut butter inoculated with a cocktail of four Salmonella serovars (7 log CFU/g) was used to contaminate the equipment (75 L). The system was then emptied of peanut butter and treated with hot oil (90 degree C) for 2 h followed by sanitizer for 1 h. Microbial analysis of food-contact surfaces (7 locations), peanut butter, and oil were conducted. Oil contained 3.2 log CFU/mL on both trypticase soy agar with yeast extract (TSAYE) and xylose lysine deoxycholate (XLD), indicating hot oil alone was not sufficient to inactivate Salmonella. Environmental sampling found 0.25-1.12 log CFU/cm2 remaining on processing equipment. After the isopropanol sanitation ( plus or minus quaternary ammonium compounds), no Salmonella was detected in environmental samples on XLD (<0.16 log CFU/cm2). These data suggest that a two-step hot oil clean and isopropanol sanitization treatment may eliminate pathogenic Salmonella from contaminated equipment. JF - Food Microbiology AU - Grasso, Elizabeth M AU - Grove, Stephen F AU - Halik, Lindsay A AU - Arritt, Fletcher AU - Keller, Susanne E AD - Office of the Commissioner, U.S. Food and Drug Administration, 6502 S. Archer Road, Bedford Park, IL 60501-1957, USA Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 100 EP - 106 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Peanut butter KW - Salmonella KW - Sanitation KW - Arachis hypogaea KW - Agar KW - Ammonium KW - Data processing KW - Xylose KW - Quaternary ammonium compounds KW - Food KW - Lysine KW - Shelf life KW - Food contamination KW - Soybeans KW - Oil KW - Colony-forming cells KW - Sanitizers KW - Sampling KW - J 02420:Plant Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647014758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Cleaning+and+sanitation+of+Salmonella-contaminated+peanut+butter+processing+equipment&rft.au=Grasso%2C+Elizabeth+M%3BGrove%2C+Stephen+F%3BHalik%2C+Lindsay+A%3BArritt%2C+Fletcher%3BKeller%2C+Susanne+E&rft.aulast=Grasso&rft.aufirst=Elizabeth&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Ammonium; Agar; Peanut butter; Xylose; Data processing; Quaternary ammonium compounds; Food; Lysine; Food contamination; Shelf life; Soybeans; Oil; Sanitation; Colony-forming cells; Sanitizers; Sampling; Arachis hypogaea; Salmonella DO - http://dx.doi.org/10.1016/j.fm.2014.03.003 ER - TY - JOUR T1 - Evaluation of loop-mediated isothermal amplification for the rapid, reliable, and robust detection of Salmonella in produce AN - 1647006779; 21290812 AB - Rapid, reliable, and robust detection of Salmonella in produce remains a challenge. In this study, loop-mediated isothermal amplification (LAMP) was comprehensively evaluated against real-time quantitative PCR (qPCR) for detecting diverse Salmonella serovars in various produce items (cantaloupe, pepper, and several varieties of lettuce, sprouts, and tomato). To mimic real-world contamination events, produce samples were surface-inoculated with low concentrations (1.1-2.9 CFU/25 g) of individual Salmonella strains representing ten serovars and tested after aging at 4 degree C for 48 h. Four DNA extraction methods were also compared using produce enrichment broths. False-positive or false-negative results were not observed among 178 strains (151 Salmonella and 27 non-Salmonella) used to evaluate assay specificity. The detection limits for LAMP were 1.8-4 CFU per reaction in pure culture and 104-106 CFU per 25 g (i.e., 102-104 CFU per g) in produce without enrichment, comparable to those obtained by qPCR. After 6-8 h of enrichment, both LAMP and qPCR consistently detected these low concentrations of Salmonella of diverse serovars in all produce items except sprouts. The PrepMan Ultra sample preparation reagent yielded the best results among the four DNA extraction methods. Upon further validation, LAMP may be a valuable tool for routine Salmonella testing in produce. The difficulty of detecting Salmonella in sprouts, whether using LAMP or qPCR, warrants further study. JF - Food Microbiology AU - Yang, Qianru AU - Wang, Fei AU - Jones, Kelly L AU - Meng, Jianghong AU - Prinyawiwatkul, Witoon AU - Ge, Beilei AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 485 EP - 493 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Detection KW - LAMP KW - Produce KW - qPCR KW - Salmonella KW - Lycopersicon esculentum KW - Pure culture KW - Cucumis melo KW - Colony-forming cells KW - Aging KW - Polymerase chain reaction KW - Food contamination KW - J 02420:Plant Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647006779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Evaluation+of+loop-mediated+isothermal+amplification+for+the+rapid%2C+reliable%2C+and+robust+detection+of+Salmonella+in+produce&rft.au=Yang%2C+Qianru%3BWang%2C+Fei%3BJones%2C+Kelly+L%3BMeng%2C+Jianghong%3BPrinyawiwatkul%2C+Witoon%3BGe%2C+Beilei&rft.aulast=Yang&rft.aufirst=Qianru&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.09.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Pure culture; Colony-forming cells; Aging; Polymerase chain reaction; Food contamination; Lycopersicon esculentum; Cucumis melo; Salmonella DO - http://dx.doi.org/10.1016/j.fm.2014.09.011 ER - TY - JOUR T1 - Re-annotation of presumed noncoding disease/trait-associated genetic variants by integrative analyses. AN - 1667958585; 25819875 AB - Using RefSeq annotations, most disease/trait-associated genetic variants identified by genome-wide association studies (GWAS) appear to be located within intronic or intergenic regions, which makes it difficult to interpret their functions. We reassessed GWAS-Associated single-nucleotide polymorphisms (herein termed as GASs) for their potential functionalities using integrative approaches. 8834 of 9184 RefSeq "noncoding" GASs were reassessed to have potential regulatory functionalities. As examples, 3 variants (rs3130320, rs3806932 and rs6890853) were shown to have regulatory properties in HepG2, A549 and 293T cells. Except rs3130320 as a known expression quantitative trait loci (eQTL), rs3806932 and rs6890853 were not reported as eQTLs in previous reports. 1999 of 9184 "noncoding" GASs were re-annotated to the promoters or intragenic regions using Ensembl, UCSC and AceView gene annotations but they were not annotated into corresponding regions in RefSeq database. Moreover, these GAS-harboring genes were broadly expressed across different tissues and a portion of them was expressed in a tissue-specific manner, suggesting that they could be functional. Collectively, our study demonstrates the benefits of using integrative analyses to interpret genetic variants and may help to predict or explain disease susceptibility more accurately and comprehensively. JF - Scientific reports AU - Chen, Geng AU - Yu, Dianke AU - Chen, Jiwei AU - Cao, Ruifang AU - Yang, Juan AU - Wang, Huan AU - Ji, Xiangjun AU - Ning, Baitang AU - Shi, Tieliu AD - 1] The Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, the Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China [2] Center for Pharmacogenomics, School of Pharmacy, Fudan University, Shanghai 201203, China. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; The Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, the Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China. Y1 - 2015/03/30/ PY - 2015 DA - 2015 Mar 30 SP - 9453 VL - 5 KW - Index Medicus KW - Gene Expression Profiling KW - Promoter Regions, Genetic KW - Hep G2 Cells KW - Humans KW - Polymorphism, Single Nucleotide -- genetics KW - Molecular Sequence Annotation KW - Quantitative Trait Loci -- genetics KW - Genetic Predisposition to Disease KW - Databases, Genetic KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667958585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Re-annotation+of+presumed+noncoding+disease%2Ftrait-associated+genetic+variants+by+integrative+analyses.&rft.au=Chen%2C+Geng%3BYu%2C+Dianke%3BChen%2C+Jiwei%3BCao%2C+Ruifang%3BYang%2C+Juan%3BWang%2C+Huan%3BJi%2C+Xiangjun%3BNing%2C+Baitang%3BShi%2C+Tieliu&rft.aulast=Chen&rft.aufirst=Geng&rft.date=2015-03-30&rft.volume=5&rft.issue=&rft.spage=9453&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep09453 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-25 N1 - Date created - 2015-03-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nature. 2013 Oct 17;502(7471):333-9 [24132290] Genome Res. 2012 Sep;22(9):1760-74 [22955987] Mol Psychiatry. 2014 Feb;19(2):228-34 [23319000] Nat Genet. 2014 Mar;46(3):310-5 [24487276] Nat Genet. 2011 Mar;43(3):246-52 [21297633] Cell. 2013 Mar 14;152(6):1298-307 [23498938] RNA. 2013 Apr;19(4):479-89 [23431329] Hum Mol Genet. 2013 May 15;22(10):2119-27 [23314186] Nature. 2013 May 2;497(7447):127-31 [23615609] Hum Genet. 2013 Aug;132(8):899-911 [23572138] Science. 2013 Oct 4;342(6154):1235587 [24092746] Nat Biotechnol. 2010 May;28(5):511-5 [20436464] Nature. 2010 Aug 5;466(7307):707-13 [20686565] Nucleic Acids Res. 2010 Sep;38(16):e164 [20601685] PLoS Comput Biol. 2010;6(12):e1001025 [21152010] Genet Epidemiol. 2011 Feb;35(2):125-32 [21254220] PLoS Genet. 2011 Mar;7(3):e1001323 [21408207] Nat Methods. 2011 Jun;8(6):469-77 [21623353] Genome Biol. 2011;12(2):R13 [21310039] Nature. 2011 Oct 27;478(7370):476-82 [21993624] Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 [22064851] Nucleic Acids Res. 2012 Jan;40(Database issue):D130-5 [22121212] Nucleic Acids Res. 2012 Jan;40(Database issue):D1047-54 [22139925] Nat Protoc. 2012 Mar;7(3):562-78 [22383036] Genome Res. 2012 Sep;22(9):1748-59 [22955986] Circ Cardiovasc Genet. 2009 Aug;2(4):322-8 [20031603] Hum Mol Genet. 2010 Apr 15;19(8):1479-91 [20093296] Nucleic Acids Res. 2014 Jan;42(Database issue):D1001-6 [24316577] Genome Res. 2012 Sep;22(9):1790-7 [22955989] Nature. 2012 Sep 6;489(7414):57-74 [22955616] Nature. 2012 Sep 6;489(7414):101-8 [22955620] Science. 2012 Sep 7;337(6099):1190-5 [22955828] Am J Hum Genet. 2012 Oct 5;91(4):721-8 [23000144] Nature. 2012 Nov 1;491(7422):119-24 [23128233] Nat Biotechnol. 2012 Nov;30(11):1095-106 [23138309] Nucleic Acids Res. 2013 Jan;41(Database issue):D64-9 [23155063] Nucleic Acids Res. 2013 Jan;41(Database issue):D48-55 [23203987] PLoS Genet. 2013;9(1):e1003190 [23341777] PLoS Genet. 2013;9(1):e1003201 [23341781] Nat Genet. 2013 Feb;45(2):191-6 [23263487] Nat Genet. 2013 Feb;45(2):202-7 [23291587] Biochem Biophys Res Commun. 2000 Mar 24;269(3):692-6 [10720478] Genes Dev. 2003 Feb 15;17(4):419-37 [12600935] Genome Res. 2005 Aug;15(8):1034-50 [16024819] Science. 2005 Oct 14;310(5746):317-20 [16224024] Genome Biol. 2006;7 Suppl 1:S12.1-14 [16925834] Nat Genet. 2007 Feb;39(2):212-7 [17206144] Nat Genet. 2007 May;39(5):638-44 [17401364] Nucleic Acids Res. 2008 Jun;36(10):3420-35 [18445632] Nat Genet. 2008 Nov;40(11):1307-12 [18794855] Nat Rev Genet. 2009 Mar;10(3):155-9 [19188922] Nat Genet. 2009 Mar;41(3):342-7 [19198610] Nat Rev Genet. 2009 Apr;10(4):241-51 [19293820] Bioinformatics. 2009 Jun 15;25(12):i54-62 [19478016] Genome Biol. 2009;10(3):R25 [19261174] Nat Genet. 2009 Oct;41(10):1094-9 [19734903] Nat Genet. 2010 Apr;42(4):289-91 [20208534] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep09453 ER - TY - CPAPER T1 - Systems Pharmacology for Prediction of Adverse Drug Events T2 - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AN - 1669822583; 6341272 JF - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AU - Abernethy, Darrell Y1 - 2015/03/28/ PY - 2015 DA - 2015 Mar 28 KW - Prediction KW - Pharmacology KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.atitle=Systems+Pharmacology+for+Prediction+of+Adverse+Drug+Events&rft.au=Abernethy%2C+Darrell&rft.aulast=Abernethy&rft.aufirst=Darrell&rft.date=2015-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/Annual_Meeting_EB_2015/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Multi-wall Carbon Nanotubes and Carbon Nanofibers: Toxicological Characterization in the Lungs T2 - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AN - 1669822468; 6341211 JF - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AU - Porter, Dale Y1 - 2015/03/28/ PY - 2015 DA - 2015 Mar 28 KW - Carbon KW - Lung KW - nanotubes KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.atitle=Multi-wall+Carbon+Nanotubes+and+Carbon+Nanofibers%3A+Toxicological+Characterization+in+the+Lungs&rft.au=Porter%2C+Dale&rft.aulast=Porter&rft.aufirst=Dale&rft.date=2015-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/Annual_Meeting_EB_2015/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - The Necessity of Publishing Replication and Failure to Replicate Studies: Criteria and Venues T2 - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AN - 1669822457; 6341242 JF - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AU - Abernethy, Darrell Y1 - 2015/03/28/ PY - 2015 DA - 2015 Mar 28 KW - Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.atitle=The+Necessity+of+Publishing+Replication+and+Failure+to+Replicate+Studies%3A+Criteria+and+Venues&rft.au=Abernethy%2C+Darrell&rft.aulast=Abernethy&rft.aufirst=Darrell&rft.date=2015-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/Annual_Meeting_EB_2015/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - New publicly available chemical query language, CSRML, to support chemotype representations for application to data mining and modeling. AN - 1666294790; 25647539 AB - Chemotypes are a new approach for representing molecules, chemical substructures and patterns, reaction rules, and reactions. Chemotypes are capable of integrating types of information beyond what is possible using current representation methods (e.g., SMARTS patterns) or reaction transformations (e.g., SMIRKS, reaction SMILES). Chemotypes are expressed in the XML-based Chemical Subgraphs and Reactions Markup Language (CSRML), and can be encoded not only with connectivity and topology but also with properties of atoms, bonds, electronic systems, or molecules. CSRML has been developed in parallel with a public set of chemotypes, i.e., the ToxPrint chemotypes, which are designed to provide excellent coverage of environmental, regulatory, and commercial-use chemical space, as well as to represent chemical patterns and properties especially relevant to various toxicity concerns. A software application, ChemoTyper has also been developed and made publicly available in order to enable chemotype searching and fingerprinting against a target structure set. The public ChemoTyper houses the ToxPrint chemotype CSRML dictionary, as well as reference implementation so that the query specifications may be adopted by other chemical structure knowledge systems. The full specifications of the XML-based CSRML standard used to express chemotypes are publicly available to facilitate and encourage the exchange of structural knowledge. JF - Journal of chemical information and modeling AU - Yang, Chihae AU - Tarkhov, Aleksey AU - Marusczyk, Jörg AU - Bienfait, Bruno AU - Gasteiger, Johann AU - Kleinoeder, Thomas AU - Magdziarz, Tomasz AU - Sacher, Oliver AU - Schwab, Christof H AU - Schwoebel, Johannes AU - Terfloth, Lothar AU - Arvidson, Kirk AU - Richard, Ann AU - Worth, Andrew AU - Rathman, James AD - †Molecular Networks GmbH, 91052 Erlangen, Germany. ; ∥US Food and Drug Administration Center for Food Safety and Applied Nutrition, Office of Food Additive Safety (FDA CFSAN OFAS), College Park, Maryland 20740, United States. ; ⊥National Center for Computational Toxicology, US Environmental Protection Agency (EPA), Research Triangle Park, North Carolina 27711, United States. ; #EC Joint Research Centre (JRC), I-21027 Ispra, Italy. ; ‡Altamira LLC, Columbus, Ohio 43235, United States. Y1 - 2015/03/23/ PY - 2015 DA - 2015 Mar 23 SP - 510 EP - 528 VL - 55 IS - 3 KW - Phosphoric Acids KW - 0 KW - phosphoric acid KW - E4GA8884NN KW - Index Medicus KW - Molecular Structure KW - Databases, Factual KW - Toxicology -- methods KW - User-Computer Interface KW - Phosphoric Acids -- chemistry KW - Structure-Activity Relationship KW - Software KW - Programming Languages KW - Data Mining KW - Chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1666294790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Care+Management+Science&rft.atitle=A+Markov+decision+model+for+determining+optimal+outpatient+scheduling&rft.au=Patrick%2C+Jonathan&rft.aulast=Patrick&rft.aufirst=Jonathan&rft.date=2012-06-01&rft.volume=15&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Health+Care+Management+Science&rft.issn=13869620&rft_id=info:doi/10.1007%2Fs10729-011-9185-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-10 N1 - Date created - 2015-03-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/ci500667v ER - TY - CPAPER T1 - Particle Characterization and Toxicological Evaluation of Pulmonary Exposure to Graphenes of Different Sizes T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822493; 6340627 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Roberts, J AU - Mercer, R AU - Sager, T AU - Kenyon, A AU - Bilgesu, S AU - Scabilloni, J AU - Seehra, M AU - Geddam, U AU - Leonard, S AU - Fix, N AU - Schwegler-Berry, D AU - Chaudhuri, I AU - Kyrlidis, A AU - Yingling, B AU - Wolfarth, M AU - Porter, D AU - Castranova, V AU - Erdely, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Lung KW - Particulates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Particle+Characterization+and+Toxicological+Evaluation+of+Pulmonary+Exposure+to+Graphenes+of+Different+Sizes&rft.au=Roberts%2C+J%3BMercer%2C+R%3BSager%2C+T%3BKenyon%2C+A%3BBilgesu%2C+S%3BScabilloni%2C+J%3BSeehra%2C+M%3BGeddam%2C+U%3BLeonard%2C+S%3BFix%2C+N%3BSchwegler-Berry%2C+D%3BChaudhuri%2C+I%3BKyrlidis%2C+A%3BYingling%2C+B%3BWolfarth%2C+M%3BPorter%2C+D%3BCastranova%2C+V%3BErdely%2C+A&rft.aulast=Roberts&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Determining the Predictive Capability of In Vitro Microphysiological Systems to Answer Critical Regulatory Questions T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822474; 6340723 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Fitzpatrick, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Prediction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Determining+the+Predictive+Capability+of+In+Vitro+Microphysiological+Systems+to+Answer+Critical+Regulatory+Questions&rft.au=Fitzpatrick%2C+S&rft.aulast=Fitzpatrick&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Genotoxic and Epigenotoxic Effects of Chemical Exposures: One Side of the Same Coin? T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822452; 6340861 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Pogribny, I Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Genotoxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Genotoxic+and+Epigenotoxic+Effects+of+Chemical+Exposures%3A+One+Side+of+the+Same+Coin%3F&rft.au=Pogribny%2C+I&rft.aulast=Pogribny&rft.aufirst=I&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Bugs to Drugs: The Microbiome in Human Health, Disease, and Therapeutics T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822419; 6340645 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Goering, P Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Drugs KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Bugs+to+Drugs%3A+The+Microbiome+in+Human+Health%2C+Disease%2C+and+Therapeutics&rft.au=Goering%2C+P&rft.aulast=Goering&rft.aufirst=P&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Experiences with Submission of Genomic Data for Human Risk Assessment T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822377; 6340811 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Leighton, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment KW - Data processing KW - genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Regulatory+Experiences+with+Submission+of+Genomic+Data+for+Human+Risk+Assessment&rft.au=Leighton%2C+J&rft.aulast=Leighton&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Proinflammatory Responses and Inflammasome Activation by Sintered Indium-Tin Oxide Particles T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822323; 6340846 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Badding, M AU - Fix, N AU - Leonard, S AU - Cummings, K Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - oxides KW - Particulates KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Proinflammatory+Responses+and+Inflammasome+Activation+by+Sintered+Indium-Tin+Oxide+Particles&rft.au=Badding%2C+M%3BFix%2C+N%3BLeonard%2C+S%3BCummings%2C+K&rft.aulast=Badding&rft.aufirst=M&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Application of a Probabilistic Framework to a Biologically Based Dose-Response Pregnancy Model to Evaluate Thyroidal Effects for Environmental Exposures to Perchlorate T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822291; 6340804 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Lumen, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Perchlorate KW - Dose-response effects KW - Perchloric acid KW - Environmental factors KW - Models KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Application+of+a+Probabilistic+Framework+to+a+Biologically+Based+Dose-Response+Pregnancy+Model+to+Evaluate+Thyroidal+Effects+for+Environmental+Exposures+to+Perchlorate&rft.au=Lumen%2C+A&rft.aulast=Lumen&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Quantifying "Stress" in Epidemiological Studies T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822022; 6340616 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Miller, D Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Quantifying+%22Stress%22+in+Epidemiological+Studies&rft.au=Miller%2C+D&rft.aulast=Miller&rft.aufirst=D&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Overview of Combination Products: Introduction, Definitions, Terms, High-Level Review of New FDA GMP Rules T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821999; 6340485 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Nguyen, T Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Reviews KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Regulatory+Overview+of+Combination+Products%3A+Introduction%2C+Definitions%2C+Terms%2C+High-Level+Review+of+New+FDA+GMP+Rules&rft.au=Nguyen%2C+T&rft.aulast=Nguyen&rft.aufirst=T&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - US FDA's GRAS Notification Program: Considerations Regarding Oversight of Food Ingredient Safety T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821960; 6340785 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Mattia, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Food KW - Safety KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=US+FDA%27s+GRAS+Notification+Program%3A+Considerations+Regarding+Oversight+of+Food+Ingredient+Safety&rft.au=Mattia%2C+A&rft.aulast=Mattia&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Derivation of Tolerable Intake Values for Compounds with Limited Toxicity Data T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821154; 6340494 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Brown, R Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Data processing KW - Toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Derivation+of+Tolerable+Intake+Values+for+Compounds+with+Limited+Toxicity+Data&rft.au=Brown%2C+R&rft.aulast=Brown&rft.aufirst=R&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Effect of Furan on Transcriptomic and Gene- Specific DNA Methylation Changes in the Livers of Fisher 344 Rats in a Two-Year Carcinogenicity Study T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821123; 6340727 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Tryndyak, V AU - Ivanovsky, S AU - Han, T AU - Fuscoe, J AU - Beland, F AU - Pogribny, I Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Rats KW - Carcinogenicity KW - DNA methylation KW - Liver KW - Furans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Effect+of+Furan+on+Transcriptomic+and+Gene-+Specific+DNA+Methylation+Changes+in+the+Livers+of+Fisher+344+Rats+in+a+Two-Year+Carcinogenicity+Study&rft.au=Tryndyak%2C+V%3BIvanovsky%2C+S%3BHan%2C+T%3BFuscoe%2C+J%3BBeland%2C+F%3BPogribny%2C+I&rft.aulast=Tryndyak&rft.aufirst=V&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Approaches and Challenges for Cancer Immunotherapy from a Regulatory Perspective T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821001; 6340483 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Ricci, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Immunotherapy KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Approaches+and+Challenges+for+Cancer+Immunotherapy+from+a+Regulatory+Perspective&rft.au=Ricci%2C+S&rft.aulast=Ricci&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - The Role of Toxicologists in a Federal Organization T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820968; 6340795 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Ghosh, C Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Organizations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=The+Role+of+Toxicologists+in+a+Federal+Organization&rft.au=Ghosh%2C+C&rft.aulast=Ghosh&rft.aufirst=C&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Infant Formula Regulation: Nutritional Adequacy and Ingredient Safety T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820903; 6340620 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Assar, C Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Infant formulas KW - Safety KW - Nutrition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Infant+Formula+Regulation%3A+Nutritional+Adequacy+and+Ingredient+Safety&rft.au=Assar%2C+C&rft.aulast=Assar&rft.aufirst=C&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - FDA Reviewer Perspective--Considerations for Bench, Biocompatibility, and Animal Testing of Absorbable Drug-Eluting Stents T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820825; 6340489 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Goode, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Drug delivery KW - Implants KW - FDA KW - biocompatibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=FDA+Reviewer+Perspective--Considerations+for+Bench%2C+Biocompatibility%2C+and+Animal+Testing+of+Absorbable+Drug-Eluting+Stents&rft.au=Goode%2C+J&rft.aulast=Goode&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Pulmonary Toxicity of Graphene Nanomaterials: An Emerging Concern in Manufacturing and Applications? T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820819; 6340624 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Roberts, J AU - Erdely, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Lung KW - Toxicity KW - nanotechnology KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Pulmonary+Toxicity+of+Graphene+Nanomaterials%3A+An+Emerging+Concern+in+Manufacturing+and+Applications%3F&rft.au=Roberts%2C+J%3BErdely%2C+A&rft.aulast=Roberts&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Perspective for Nonclinical Development and Safety Assessment of Antibody- Drug Conjugates T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820756; 6340543 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Ricci, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Safety KW - Drug development KW - Drug screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Regulatory+Perspective+for+Nonclinical+Development+and+Safety+Assessment+of+Antibody-+Drug+Conjugates&rft.au=Ricci%2C+S&rft.aulast=Ricci&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Thinking beyond General Toxicology Studies for Immunotherapeutics T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820733; 6340606 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Helms, W Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Thinking+beyond+General+Toxicology+Studies+for+Immunotherapeutics&rft.au=Helms%2C+W&rft.aulast=Helms&rft.aufirst=W&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Suitability of polystyrene as a functional barrier layer in coloured food contact materials AN - 1691286366; PQ0001543452 AB - Functional barriers in food contact materials (FCMs) are used to prevent or reduce migration from inner layers in multilayer structures to food. The effectiveness of functional barrier layers was investigated in coloured polystyrene (PS) bowls due to their intended condition of use with hot liquids such as soups or stew. Migration experiments were performed over a 10-day period using USFDA-recommended food simulants (10% ethanol, 50% ethanol, corn oil and Miglyol) along with several other food oils. At the end of the 10 days, solvent dyes had migrated from the PS bowls at 12, 1 and 31 000 ng cm super(-) super(2) into coconut oil, palm kernel oil and Miglyol respectively, and in coconut oil and Miglyol the colour change was visible to the human eye. Scanning electron microscope (SEM) images revealed that the functional barrier was no longer intact for the bowls exposed to coconut oil, palm kernel oil, Miglyol, 10% ethanol, 50% ethanol and goat's milk. Additional tests showed that 1-dodecanol, a lauryl alcohol derived from palm kernel oil and coconut oil, was present in the PS bowls at an average concentration of 11 mg kg super(-1). This compound is likely to have been used as a dispersing agent for the solvent dye and aided the migration of the solvent dye from the PS bowl into the food simulant. The solvent dye was not found in the 10% ethanol, 50% ethanol and goat's milk food simulants above their respective limits of detection, which is likely to be due to its insolubility in aqueous solutions. A disrupted barrier layer is of concern because if there are unregulated materials in the inner layers of the laminate, they may migrate to food, and therefore be considered unapproved food additives resulting in the food being deemed adulterated under the Federal Food Drug and Cosmetic Act. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Genualdi, Susan AU - Addo Ntim, Susana AU - Begley, Timothy AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA Y1 - 2015/03/04/ PY - 2015 DA - 2015 Mar 04 SP - 395 EP - 402 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 3 SN - 1944-0049, 1944-0049 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Alcohol KW - Milk KW - Solvents KW - Cosmetics KW - Migration KW - Oil KW - Food additives KW - Dyes KW - Corn KW - Drugs KW - Ethanol KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691286366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Suitability+of+polystyrene+as+a+functional+barrier+layer+in+coloured+food+contact+materials&rft.au=Genualdi%2C+Susan%3BAddo+Ntim%2C+Susana%3BBegley%2C+Timothy&rft.aulast=Genualdi&rft.aufirst=Susan&rft.date=2015-03-04&rft.volume=32&rft.issue=3&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2014.1002116 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Risk assessment; Oil; Alcohol; Food additives; Milk; Dyes; Corn; Solvents; Cosmetics; Drugs; Migration; Ethanol DO - http://dx.doi.org/10.1080/19440049.2014.1002116 ER - TY - JOUR T1 - Effect of interferents on the performance of direct-reading organic vapor monitors AN - 1664200422; PQ0001232352 AB - Direct-reading organic vapor monitors are often used to measure volatile organic compound concentrations in complex chemical gas mixtures. However, there is a paucity of data on the impact of multiple gases on monitor performance, even though it is known that monitor sensitivity may vary by chemical. This study investigated the effects of interferents on the performance of the MIRAN SapphIRe Portable Ambient Air Analyzer (SAP) and Century Portable Toxic Vapor Analyzer (TVA-1000) when sampling a specific agent of interest (cyclohexane). The TVA-1000 contained a dual detector: a photoionization detector (PID) and a flame ionization detector (FID). Three devices of each monitor were challenged with different combinations of cyclohexane and potential interferent vapors (hexane, methyl ethyl ketone, trichloroethylene, and toluene) at 21 degree C and 90% relative humidity (RH), an extreme environmental condition. Five replicates at four target concentrations were tested: 30, 150, 300, and 475 ppm. Multiple proportions of cyclohexane to interferent enabled the determination of the interferent effect on monitor performance. The monitor concentrations were compared to reference concentrations measured using NIOSH Method 1500. Three scenarios were investigated: no response factor, cyclohexane response factor, and weighted-mixed response factor applied. False negatives occurred more frequently for PID (21.1%), followed by FID (4.8%) and SAP (0.2%). Measurements from all monitors generally had a positive bias compared to the reference measurements. Some monitor measurements exceeded twice the reference concentrations: PID (36.8%), SAP (19.8%), and FID (6.3%). Evaluation of the 95% confidence intervals indicated that performance of all monitors varied by concentration. In addition, the performance of the PID and SAP varied by presence of an interfering compound, especially toluene and hexane for the PID and trichloroethylene for the SAP. Variability and bias associated with all these monitors preclude supplanting traditional sorbent-based tube methods for measuring volatile organic compounds (VOCs), especially for compliance monitoring. Implications:Industrial hygienists need to use care when using any of the three monitor detection types to measure the concentration of unknown chemical mixtures. Monitor performance is affected by the presence of interferents. Application of manufacturer recommended response factors may not adequately scale measurements to minimize monitor bias when compared to standard reference methods. Users should calibrate their monitors to a known reference method prior to use, if possible. Each of the monitors has its own limitations, which should be considered to ensure quality measurements are reported. JF - Journal of the Air & Waste Management Association AU - LeBouf, Ryan F AU - Coffey, Christopher C AD - Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2015/03/04/ PY - 2015 DA - 2015 Mar 04 SP - 261 EP - 269 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 65 IS - 3 SN - 1096-2247, 1096-2247 KW - Environment Abstracts; Pollution Abstracts KW - Sensitivity KW - Vapors KW - Gases KW - Ketones KW - Toluene KW - Compliance KW - Solvents KW - Humidity KW - Trichloroethylene KW - Environmental conditions KW - Volatile organic compounds KW - P 4000:WASTE MANAGEMENT KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664200422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Effect+of+interferents+on+the+performance+of+direct-reading+organic+vapor+monitors&rft.au=LeBouf%2C+Ryan+F%3BCoffey%2C+Christopher+C&rft.aulast=LeBouf&rft.aufirst=Ryan&rft.date=2015-03-04&rft.volume=65&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2014.986308 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Sensitivity; Vapors; Ketones; Gases; Toluene; Compliance; Solvents; Humidity; Trichloroethylene; Environmental conditions; Volatile organic compounds DO - http://dx.doi.org/10.1080/10962247.2014.986308 ER - TY - CPAPER T1 - Drug Interactions: An Evolution in Drug Development T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822479; 6340398 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Huang, Shiew-Mei Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Drug interaction KW - Drug development KW - Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Drug+Interactions%3A+An+Evolution+in+Drug+Development&rft.au=Huang%2C+Shiew-Mei&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Bioequivalence Standards for Narrow Therapeutic Index (NTI) Drugs: Are They Stringent Enough to Ensure Safety and Efficacy? T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822161; 6340336 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Fang, Lanyan Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Safety KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Bioequivalence+Standards+for+Narrow+Therapeutic+Index+%28NTI%29+Drugs%3A+Are+They+Stringent+Enough+to+Ensure+Safety+and+Efficacy%3F&rft.au=Fang%2C+Lanyan&rft.aulast=Fang&rft.aufirst=Lanyan&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Role of Clinical Pharmacology in Developing Evidence of Efectiveness T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822064; 6340296 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Sinha, Vikram Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Role+of+Clinical+Pharmacology+in+Developing+Evidence+of+Efectiveness&rft.au=Sinha%2C+Vikram&rft.aulast=Sinha&rft.aufirst=Vikram&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Impact of Altered in Vitro Dissolution Profile on Warfarin in Vivo Pharmacokinetics Performance- Population Physiologically Based Pharmacokinetic (PBPK) Simulation. T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821108; 6340439 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Fan, J AU - Zhang, X AU - Lionberger, R Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Physiology KW - Dissolution KW - Simulation KW - Warfarin KW - Ecosystem disturbance KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Impact+of+Altered+in+Vitro+Dissolution+Profile+on+Warfarin+in+Vivo+Pharmacokinetics+Performance-+Population+Physiologically+Based+Pharmacokinetic+%28PBPK%29+Simulation.&rft.au=Fan%2C+J%3BZhang%2C+X%3BLionberger%2C+R&rft.aulast=Fan&rft.aufirst=J&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Pediatric Clinical Pharmacology T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821038; 6340402 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Green, Dionna Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pediatrics KW - Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Pediatric+Clinical+Pharmacology&rft.au=Green%2C+Dionna&rft.aulast=Green&rft.aufirst=Dionna&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Milestones: Sex-Related Insights from Post-Marketing Data T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820810; 6340350 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Kim, Myong-Jin Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Milestones%3A+Sex-Related+Insights+from+Post-Marketing+Data&rft.au=Kim%2C+Myong-Jin&rft.aulast=Kim&rft.aufirst=Myong-Jin&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER -