TY - JOUR T1 - Bias from Differential Exposure Measurement Error in a Study of Flight Attendants AN - 1762365043; PQ0002504350 AB - BACKGROUND: Self-reported occupational exposures are often used in epidemiological studies when actual exposure measurements are unavailable, which could cause measurement error and bias study results. This study provides a numeric example of this potential bias. METHODS: A study of block hours and preterm birth was used as an illustrative example. This study included 577 flight attendants, ages 18-45 yr, who gave birth to a term (37 or greater gestational weeks) or preterm (20-36 gestational weeks) infant between 1992 and 1996. Flight attendants self-reported the number of block hours flown during the first trimester of pregnancy; the number of block hours flown during the first trimester of pregnancy was also calculated from airline records. No adjustment for confounding was performed for this illustrative example. RESULTS: Although flight attendants having term and preterm births self-reported similar hours worked during the first trimester (median 213 vs. 215 block hours), airline records showed that flight attendants having term births worked more hours than those having preterm births (median 146 vs. 104 block hours). Using self-reported block hours, there was no association between block hours and preterm birth; when using airline records, an inverse association was observed. DISCUSSION: In this example, differential measurement error from use of self-reported block hours obscured an inverse association apparent when using airline records, demonstrating the importance of accurate exposure assessment for identifying occupational risk factors for health outcomes. JF - Aerospace Medicine and Human Performance AU - Johnson, Candice Y AU - Grajewski, Barbara AD - National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1090 Tusculum Ave., MS R-15, Cincinnati, OH 45226, cyjohnson@cdc.gov Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 990 EP - 993 PB - Aerospace Medical Association, 320 S. Henry St. Alexandria VA 22314-3579 United States VL - 86 IS - 11 SN - 2375-6314, 2375-6314 KW - Health & Safety Science Abstracts KW - block hours KW - exposure assessment KW - preterm birth KW - Age KW - Risk factors KW - Airlines KW - Human factors KW - Occupational exposure KW - Pregnancy KW - Infants KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762365043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerospace+Medicine+and+Human+Performance&rft.atitle=Bias+from+Differential+Exposure+Measurement+Error+in+a+Study+of+Flight+Attendants&rft.au=Johnson%2C+Candice+Y%3BGrajewski%2C+Barbara&rft.aulast=Johnson&rft.aufirst=Candice&rft.date=2015-11-01&rft.volume=86&rft.issue=11&rft.spage=990&rft.isbn=&rft.btitle=&rft.title=Aerospace+Medicine+and+Human+Performance&rft.issn=23756314&rft_id=info:doi/10.3357%2FAMHP.4321.2015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 6 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Age; Risk factors; Airlines; Human factors; Occupational exposure; Infants; Pregnancy DO - http://dx.doi.org/10.3357/AMHP.4321.2015 ER - TY - JOUR T1 - A Phase 1 Randomized, Blinded Comparison of the Pharmacokinetics and Colonic Distribution of Three Candidate Rectal Microbicide Formulations of Tenofovir 1% Gel with Simulated Unprotected Sex (CHARM-02). AN - 1731784475; 26227279 AB - CHARM-02 is a crossover, double-blind, randomized trial to compare the safety and pharmacokinetics of three rectally applied tenofovir 1% gel candidate rectal microbicides of varying osmolalities: vaginal formulation (VF) (3111 mOsmol/kg), the reduced glycerin vaginal formulation (RGVF) (836 mOsmol/kg), and an isoosmolal rectal-specific formulation (RF) (479 mOsmol/kg). Participants (n = 9) received a single, 4 ml, radiolabeled dose of each gel twice, once with and once without simulated unprotected receptive anal intercourse (RAI). The safety, plasma tenofovir pharmacokinetics, colonic small molecule permeability, and SPECT/CT imaging of lower gastrointestinal distribution of drug and virus surrogate were assessed. There were no Grade 3 or 4 adverse events reported for any of the products. Overall, there were more Grade 2 adverse events in the VF group compared to RF (p = 0.006) and RGVF (p = 0.048). In the absence of simulated unprotected RAI, VF had up to 3.8-fold greater systemic tenofovir exposure, 26- to 234-fold higher colonic permeability of the drug surrogate, and 1.5- to 2-fold greater proximal migration in the colonic lumen, when compared to RF and RGVF. Similar trends were observed with simulated unprotected RAI, but most did not reach statistical significance. SPECT analysis showed 86% (standard deviation 19%) of the drug surrogate colocalized with the virus surrogate in the colonic lumen. There were no significant differences between the RGVF and RF formulation, with the exception of a higher plasma tenofovir concentration of RGVF in the absence of simulated unprotected RAI. VF had the most adverse events, highest plasma tenofovir concentrations, greater mucosal permeability of the drug surrogate, and most proximal colonic luminal migration compared to RF and RGVF formulations. There were no major differences between RF and RGVF formulations. Simultaneous assessment of toxicity, systemic and luminal pharmacokinetics, and colocalization of drug and viral surrogates substantially informs rectal microbicide product development. JF - AIDS research and human retroviruses AU - Hiruy, Hiwot AU - Fuchs, Edward J AU - Marzinke, Mark A AU - Bakshi, Rahul P AU - Breakey, Jennifer C AU - Aung, Wutyi S AU - Manohar, Madhuri AU - Yue, Chen AU - Caffo, Brian S AU - Du, Yong AU - Abebe, Kaleab Z AU - Spiegel, Hans M L AU - Rohan, Lisa C AU - McGowan, Ian AU - Hendrix, Craig W AD - 1 Department of Medicine (Clinical Pharmacology), Johns Hopkins University , Baltimore, Maryland. ; 2 Department of Biostatistics, Johns Hopkins School of Public Health , Baltimore, Maryland. ; 3 Department of Radiology, Johns Hopkins School of Medicine , Baltimore, Maryland. ; 4 Department of Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania. ; 5 HJF-DAIDS, a Division of The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Contractor to National Institute of Allergy and Infectious Diseases, National Institutes of Health , Department of Health and Human Services, Bethesda, Maryland. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1098 EP - 1108 VL - 31 IS - 11 KW - Anti-HIV Agents KW - 0 KW - Gels KW - Tenofovir KW - 99YXE507IL KW - Index Medicus KW - AIDS/HIV KW - Unsafe Sex KW - Double-Blind Method KW - Humans KW - Drug-Related Side Effects and Adverse Reactions -- pathology KW - Adult KW - Drug-Related Side Effects and Adverse Reactions -- epidemiology KW - Cross-Over Studies KW - Middle Aged KW - Administration, Rectal KW - Plasma -- chemistry KW - Male KW - Gels -- pharmacokinetics KW - Anti-HIV Agents -- pharmacokinetics KW - Tenofovir -- adverse effects KW - HIV Infections -- transmission KW - Gels -- adverse effects KW - HIV Infections -- prevention & control KW - Gels -- administration & dosage KW - Tenofovir -- pharmacokinetics KW - Anti-HIV Agents -- adverse effects KW - Anti-HIV Agents -- administration & dosage KW - Tenofovir -- administration & dosage KW - Disease Transmission, Infectious -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731784475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=A+Phase+1+Randomized%2C+Blinded+Comparison+of+the+Pharmacokinetics+and+Colonic+Distribution+of+Three+Candidate+Rectal+Microbicide+Formulations+of+Tenofovir+1%25+Gel+with+Simulated+Unprotected+Sex+%28CHARM-02%29.&rft.au=Hiruy%2C+Hiwot%3BFuchs%2C+Edward+J%3BMarzinke%2C+Mark+A%3BBakshi%2C+Rahul+P%3BBreakey%2C+Jennifer+C%3BAung%2C+Wutyi+S%3BManohar%2C+Madhuri%3BYue%2C+Chen%3BCaffo%2C+Brian+S%3BDu%2C+Yong%3BAbebe%2C+Kaleab+Z%3BSpiegel%2C+Hans+M+L%3BRohan%2C+Lisa+C%3BMcGowan%2C+Ian%3BHendrix%2C+Craig+W&rft.aulast=Hiruy&rft.aufirst=Hiwot&rft.date=2015-11-01&rft.volume=31&rft.issue=11&rft.spage=1098&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=1931-8405&rft_id=info:doi/10.1089%2FAID.2015.0098 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-12 N1 - Date created - 2015-11-07 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT01575418; ClinicalTrials.gov N1 - SuppNotes - Cited By: Biomaterials. 2013 Sep;34(28):6922-9 [23769419] Br J Clin Pharmacol. 2012 Dec;74(6):1013-22 [22404308] AIDS Res Hum Retroviruses. 2013 Nov;29(11):1487-95 [23885722] AIDS. 2013 Nov 13;27(17):2665-78 [23842129] J Nucl Cardiol. 2014 Apr;21(2):329-40 [24366822] Pharm Weekbl Sci. 1989 Feb 24;11(1):9-12 [2540479] J Infect Dis. 2007 Mar 1;195(5):703-10 [17262713] Clin Pharmacol Ther. 2008 Jan;83(1):97-105 [17507921] Med Phys. 2009 Jun;36(6):2021-33 [19610291] Lancet Infect Dis. 2010 Jul;10(7):479-88 [20610330] Science. 2010 Sep 3;329(5996):1168-74 [20643915] Sex Transm Infect. 2012 Dec;88(8):574-80 [22750885] PLoS One. 2013;8(1):e55013 [23383037] PLoS One. 2013;8(4):e60147 [23573238] J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):221-7 [23406978] AIDS. 2013 Mar 13;27(5):825-32 [23169330] J Acquir Immune Defic Syndr. 2013 Apr 15;62(5):584-9 [23334505] Lancet. 2013 Jun 15;381(9883):2083-90 [23769234] N Engl J Med. 2010 Dec 30;363(27):2587-99 [21091279] J Acquir Immune Defic Syndr. 2011 May 1;57(1):77-87 [21297479] PLoS One. 2012;7(5):e38143 [22693590] Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Apr;33(4):368-73 [22781407] N Engl J Med. 2012 Aug 2;367(5):399-410 [22784037] N Engl J Med. 2012 Aug 2;367(5):423-34 [22784038] AIDS Res Hum Retroviruses. 2015 Nov;31(11):1089-97 [26066390] PLoS One. 2015;10(5):e0125363 [25942472] PLoS One. 2012;7(8):e43071 [22937013] Curr Opin HIV AIDS. 2012 Nov;7(6):498-504 [22964888] AIDS Res Hum Retroviruses. 2012 Nov;28(11):1412-21 [22943559] AIDS Res Hum Retroviruses. 2013 Nov;29(11):1443-50 [23600365] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1089/AID.2015.0098 ER - TY - JOUR T1 - The role of haplotype in 15q25.1 locus in lung cancer risk: results of scanning chromosome 15. AN - 1728674496; 26282330 AB - The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case-control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case-control study with 2983 lung cancer patients and 3553 healthy controls of European ancestry for replication. Sliding window haplotype analysis within chromosome 15, evaluating 4722250 haplotypes and pair-wise haplotype analysis identified that CHRNA5 rs588765-rs16969968 was the most significant haplotype associated with lung cancer risk (omnibus P = 8.35×10(-15) in discovery and 7.26×10(-14) in replication), and improved the prediction of case status over that provided by the individual SNPs rs16969968 or rs588765 (likelihood ratio test P = 0.006 for rs16969968 and 3.83×10(-14) for rs588765 in discovery, 0.009 for rs16969968 and 4.62×10(-13) for rs588765 in replication, compared with rs588765-rs16969968). Compared with the wild-type homozygous diplotype, CA/CA homozygote exhibited an approximately 2-fold increase risk for lung cancer (OR = 2.12; 95% CI 1.46-3.07 in discovery, and OR = 2.01; 95% CI 1.51-2.67 in replication). Even among never-smokers, CA/CA homozygote showed an increased risk of lung cancer with borderline significance in discovery (adjusted OR = 1.75, 95% CI 0.96-3.19) and statistical significance in replication (adjusted OR = 2.10, 95% CI 1.12-3.96), compared with combined genotypes (CG/CG + CG/TG). Accordingly, rs588765-rs16969968 may be a genetic marker to lung cancer risk, even among never-smokers. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Carcinogenesis AU - Ji, Xuemei AU - Gui, Jiang AU - Han, Younghun AU - Brennan, Paul AU - Li, Yafang AU - McKay, James AU - Caporaso, Neil E AU - Bertazzi, Pier Alberto AU - Landi, Maria Teresa AU - Amos, Christopher I AD - International Agency for Research on Cancer, 69372 Lyon, France. ; Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. ; Department of Clinical Sciences and Community Health, Department of Preventive Medicine, University of Milan, Fondazione IRCCS Ca' Granda Policlinico Hospital, 20122 Milan, Italy. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1275 EP - 1283 VL - 36 IS - 11 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Haplotypes KW - Genetic Loci KW - Humans KW - Genetic Association Studies KW - Case-Control Studies KW - Smoking -- adverse effects KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Carcinoma, Squamous Cell -- genetics KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Chromosomes, Human, Pair 15 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728674496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+role+of+haplotype+in+15q25.1+locus+in+lung+cancer+risk%3A+results+of+scanning+chromosome+15.&rft.au=Ji%2C+Xuemei%3BGui%2C+Jiang%3BHan%2C+Younghun%3BBrennan%2C+Paul%3BLi%2C+Yafang%3BMcKay%2C+James%3BCaporaso%2C+Neil+E%3BBertazzi%2C+Pier+Alberto%3BLandi%2C+Maria+Teresa%3BAmos%2C+Christopher+I&rft.aulast=Ji&rft.aufirst=Xuemei&rft.date=2015-11-01&rft.volume=36&rft.issue=11&rft.spage=1275&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgv118 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-03 N1 - Date created - 2015-10-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Mol Sci. 2014;15(4):5446-57 [24686516] Int J Cancer. 2013 Apr 15;132(8):1811-20 [23011884] Int J Cancer. 1994 Nov 15;59(4):494-504 [7960219] Nature. 2008 Apr 3;452(7187):638-42 [18385739] Nat Genet. 2008 May;40(5):616-22 [18385676] BMC Public Health. 2008;8:203 [18538025] Am J Psychiatry. 2008 Sep;165(9):1163-71 [18519524] Cancer Res. 2008 Nov 15;68(22):9137-40 [19010884] Clin Cancer Res. 2009 Mar 1;15(5):1837-42 [19223495] Hum Mol Genet. 2009 Aug 15;18(16):3125-35 [19443489] Cancer Res. 2009 Aug 15;69(16):6633-41 [19654303] Cancer Res. 2009 Oct 1;69(19):7844-50 [19789337] Nat Genet. 2010 May;42(5):436-40 [20418889] Nat Genet. 2010 May;42(5):441-7 [20418890] J Surg Res. 2010 Jul;162(1):75-8 [19577767] PLoS Genet. 2010 Aug;6(8). pii: e1001053. doi: 10.1371/journal.pgen.1001053 [20700436] J Natl Cancer Inst. 2010 Sep 8;102(17):1366-70 [20733116] PLoS One. 2011;6(4):e19085 [21559498] CA Cancer J Clin. 2011 Jul-Aug;61(4):212-36 [21685461] J Natl Cancer Inst. 2011 Sep 7;103(17):1342-6 [21747048] Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2603-9 [22028403] J Biol Chem. 2012 Mar 2;287(10):7246-55 [22241472] Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):1213-21 [22573796] Nat Genet. 2012 Aug;44(8):895-9 [22797725] Cancer Epidemiol Biomarkers Prev. 2013 Feb;22(2):251-60 [23221128] Nat Genet. 2014 Jul;46(7):736-41 [24880342] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/carcin/bgv118 ER - TY - JOUR T1 - Identification of lung cancer histology-specific variants applying Bayesian framework variant prioritization approaches within the TRICL and ILCCO consortia. AN - 1728674481; 26363033 AB - Large-scale genome-wide association studies (GWAS) have likely uncovered all common variants at the GWAS significance level. Additional variants within the suggestive range (0.0001> P > 5×10(-8)) are, however, still of interest for identifying causal associations. This analysis aimed to apply novel variant prioritization approaches to identify additional lung cancer variants that may not reach the GWAS level. Effects were combined across studies with a total of 33456 controls and 6756 adenocarcinoma (AC; 13 studies), 5061 squamous cell carcinoma (SCC; 12 studies) and 2216 small cell lung cancer cases (9 studies). Based on prior information such as variant physical properties and functional significance, we applied stratified false discovery rates, hierarchical modeling and Bayesian false discovery probabilities for variant prioritization. We conducted a fine mapping analysis as validation of our methods by examining top-ranking novel variants in six independent populations with a total of 3128 cases and 2966 controls. Three novel loci in the suggestive range were identified based on our Bayesian framework analyses: KCNIP4 at 4p15.2 (rs6448050, P = 4.6×10(-7)) and MTMR2 at 11q21 (rs10501831, P = 3.1×10(-6)) with SCC, as well as GAREM at 18q12.1 (rs11662168, P = 3.4×10(-7)) with AC. Use of our prioritization methods validated two of the top three loci associated with SCC (P = 1.05×10(-4) for KCNIP4, represented by rs9799795) and AC (P = 2.16×10(-4) for GAREM, represented by rs3786309) in the independent fine mapping populations. This study highlights the utility of using prior functional data for sequence variants in prioritization analyses to search for robust signals in the suggestive range. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Carcinogenesis AU - Brenner, Darren R AU - Amos, Christopher I AU - Brhane, Yonathan AU - Timofeeva, Maria N AU - Caporaso, Neil AU - Wang, Yufei AU - Christiani, David C AU - Bickeböller, Heike AU - Yang, Ping AU - Albanes, Demetrius AU - Stevens, Victoria L AU - Gapstur, Susan AU - McKay, James AU - Boffetta, Paolo AU - Zaridze, David AU - Szeszenia-Dabrowska, Neonilia AU - Lissowska, Jolanta AU - Rudnai, Peter AU - Fabianova, Eleonora AU - Mates, Dana AU - Bencko, Vladimir AU - Foretova, Lenka AU - Janout, Vladimir AU - Krokan, Hans E AU - Skorpen, Frank AU - Gabrielsen, Maiken E AU - Vatten, Lars AU - Njølstad, Inger AU - Chen, Chu AU - Goodman, Gary AU - Lathrop, Mark AU - Vooder, Tõnu AU - Välk, Kristjan AU - Nelis, Mari AU - Metspalu, Andres AU - Broderick, Peter AU - Eisen, Timothy AU - Wu, Xifeng AU - Zhang, Di AU - Chen, Wei AU - Spitz, Margaret R AU - Wei, Yongyue AU - Su, Li AU - Xie, Dong AU - She, Jun AU - Matsuo, Keitaro AU - Matsuda, Fumihiko AU - Ito, Hidemi AU - Risch, Angela AU - Heinrich, Joachim AU - Rosenberger, Albert AU - Muley, Thomas AU - Dienemann, Hendrik AU - Field, John K AU - Raji, Olaide AU - Chen, Ying AU - Gosney, John AU - Liloglou, Triantafillos AU - Davies, Michael P A AU - Marcus, Michael AU - McLaughlin, John AU - Orlow, Irene AU - Han, Younghun AU - Li, Yafang AU - Zong, Xuchen AU - Johansson, Mattias AU - EPIC Investigators AU - Liu, Geoffrey AU - Tworoger, Shelley S AU - Le Marchand, Loic AU - Henderson, Brian E AU - Wilkens, Lynne R AU - Dai, Juncheng AU - Shen, Hongbing AU - Houlston, Richard S AU - Landi, Maria T AU - Brennan, Paul AU - Hung, Rayjean J AD - Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada, Section of Genetics, International Agency for Research on Cancer, 69372 Lyon, France, Department of Cancer Epidemiology and Prevention Research, Cancer Control Alberta, Alberta Health Services, Calgary, Alberta T2T 5C7, Canada. ; Department of Community and Family Medicine, Center for Genomic Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, NH 03766, USA. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada. ; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH8 9YL, UK. ; Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. ; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK. ; Departments of Environmental Health and Epidemiology, Harvard University School of Public Health, Boston, MA 02115, USA. ; Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, 37073 Göttingen, Germany. ; Division of Health Sciences, Cancer Center and College of Medicine, Mayo Clinic, Rochester, NY 55905, USA. ; Epidemiology Research Program, American Cancer Society, Epidemiology and Surveillance Research, Atlanta, GA 30301, USA. ; Section of Genetics, International Agency for Research on Cancer, 69372 Lyon, France. ; Population Sciences, Tisch Cancer Center and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. ; Institute of Carcinogenesis, Russian N.N.Blokhin Cancer Research Centre, 115478 Moscow, Russia. ; Department of Epidemiology, Institute of Occupational Medicine, 91348 Lodz, Poland. ; Department of Epidemiology and Cancer Prevention, The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw 02781, Poland. ; National Institute of Environmental Health, Budapest 1097, Hungary. ; Department of Health Risk Assessment, Regional Authority of Public Health, Banská Bystrica 97556, Slovak Republic. ; National Institute of Public Health, Bucharest 050463, Romania. ; Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University in Prague, 128 00 Prague 2, Czech Republic. ; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno 65653, Czech Republic. ; Department of Preventive Medicine, Palacky University, Olomouc 77515, Czech Republic. ; Department of Cancer Research and Molecular Medicine, Faculty of Medicine. ; Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine and. ; Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim 7489, Norway. ; Department of Community Medicine, University of Tromso, Tromso N-9037, Norway. ; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. ; McGill University and Genome Québec Innovation Centre, Montréal, Quebec, Canada. ; Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia. ; Department of Biomedicine, University of Bergen, Bergen 5009, Norway. ; Institute of Molecular and Cell Biology, Estonian Biocentre, Genotyping Core Facility, Tartu 51010, Estonia. ; Department of Oncology, Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK. ; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ; Department of Genetics, U.T. M.D. Anderson Cancer Center, Houston, TX 77030, USA. ; Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. ; Department of Preventive Medicine, Kyushu University Graduate School of Medicine, Fukuoka City 819-0395, Japan. ; Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. ; Department of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa-ku Nagoya 464-0021, Japan. ; Division of Epigenomics and Cancer Risk Factors, DKFZ, 69121 Heidelberg, Germany, Division of Epigenomics and Cancer Risk Factors, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), 69121 Heidelberg, Germany. ; Unit of Environmental Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany. ; Division of Epigenomics and Cancer Risk Factors, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), 69121 Heidelberg, Germany, Translational Research Unit and. ; Division of Epigenomics and Cancer Risk Factors, Translational Lung Research Center Heidelberg (TLRC-H), German Center for Lung Research (DZL), 69121 Heidelberg, Germany, Department of Thoracic Surgery, Thoraxklinik am Universitätsklinikum Heidelberg, 69117 Heidelberg, Germany. ; Roy Castle Lung Cancer Research Programme, The University of Liverpool Cancer Research Centre, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, The University of Liverpool, Liverpool L69 3BX, UK. ; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ; EPIC Investigators ; Medical Oncology and Haematology, Department of Medicine, Princess Margaret Hospital, Toronto, Ontario M5G 2M9, Canada. ; Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA, Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. ; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA. ; Keck School of Medicine, University of South California, Los Angeles, CA 90089-0911, USA and. ; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario M5T 3L9, Canada, rayjean.hung@lunenfeld.ca. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1314 EP - 1326 VL - 36 IS - 11 KW - Index Medicus KW - Humans KW - Case-Control Studies KW - Bayes Theorem KW - Genetic Predisposition to Disease KW - Genome-Wide Association Study KW - Carcinoma, Squamous Cell -- pathology KW - Carcinoma, Squamous Cell -- genetics KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Lung Neoplasms -- pathology KW - Adenocarcinoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728674481?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Identification+of+lung+cancer+histology-specific+variants+applying+Bayesian+framework+variant+prioritization+approaches+within+the+TRICL+and+ILCCO+consortia.&rft.au=Brenner%2C+Darren+R%3BAmos%2C+Christopher+I%3BBrhane%2C+Yonathan%3BTimofeeva%2C+Maria+N%3BCaporaso%2C+Neil%3BWang%2C+Yufei%3BChristiani%2C+David+C%3BBickeb%C3%B6ller%2C+Heike%3BYang%2C+Ping%3BAlbanes%2C+Demetrius%3BStevens%2C+Victoria+L%3BGapstur%2C+Susan%3BMcKay%2C+James%3BBoffetta%2C+Paolo%3BZaridze%2C+David%3BSzeszenia-Dabrowska%2C+Neonilia%3BLissowska%2C+Jolanta%3BRudnai%2C+Peter%3BFabianova%2C+Eleonora%3BMates%2C+Dana%3BBencko%2C+Vladimir%3BForetova%2C+Lenka%3BJanout%2C+Vladimir%3BKrokan%2C+Hans+E%3BSkorpen%2C+Frank%3BGabrielsen%2C+Maiken+E%3BVatten%2C+Lars%3BNj%C3%B8lstad%2C+Inger%3BChen%2C+Chu%3BGoodman%2C+Gary%3BLathrop%2C+Mark%3BVooder%2C+T%C3%B5nu%3BV%C3%A4lk%2C+Kristjan%3BNelis%2C+Mari%3BMetspalu%2C+Andres%3BBroderick%2C+Peter%3BEisen%2C+Timothy%3BWu%2C+Xifeng%3BZhang%2C+Di%3BChen%2C+Wei%3BSpitz%2C+Margaret+R%3BWei%2C+Yongyue%3BSu%2C+Li%3BXie%2C+Dong%3BShe%2C+Jun%3BMatsuo%2C+Keitaro%3BMatsuda%2C+Fumihiko%3BIto%2C+Hidemi%3BRisch%2C+Angela%3BHeinrich%2C+Joachim%3BRosenberger%2C+Albert%3BMuley%2C+Thomas%3BDienemann%2C+Hendrik%3BField%2C+John+K%3BRaji%2C+Olaide%3BChen%2C+Ying%3BGosney%2C+John%3BLiloglou%2C+Triantafillos%3BDavies%2C+Michael+P+A%3BMarcus%2C+Michael%3BMcLaughlin%2C+John%3BOrlow%2C+Irene%3BHan%2C+Younghun%3BLi%2C+Yafang%3BZong%2C+Xuchen%3BJohansson%2C+Mattias%3BEPIC+Investigators%3BLiu%2C+Geoffrey%3BTworoger%2C+Shelley+S%3BLe+Marchand%2C+Loic%3BHenderson%2C+Brian+E%3BWilkens%2C+Lynne+R%3BDai%2C+Juncheng%3BShen%2C+Hongbing%3BHoulston%2C+Richard+S%3BLandi%2C+Maria+T%3BBrennan%2C+Paul%3BHung%2C+Rayjean+J&rft.aulast=Brenner&rft.aufirst=Darren&rft.date=2015-11-01&rft.volume=36&rft.issue=11&rft.spage=1314&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgv128 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-03 N1 - Date created - 2015-10-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Carcinogenesis. 2006 May;27(5):1024-9 [16311244] Genet Epidemiol. 2006 Sep;30(6):519-30 [16800000] Am J Epidemiol. 2006 Dec 15;164(12):1233-41 [17032696] Am J Hum Genet. 2007 Apr;80(4):605-15 [17357068] Am J Hum Genet. 2007 Aug;81(2):208-27 [17668372] Am J Hum Genet. 2007 Aug;81(2):397-404 [17668389] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] Nat Rev Cancer. 2007 Oct;7(10):778-90 [17882278] Cancer Genet Cytogenet. 2007 Nov;179(1):11-8 [17981209] Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2736-44 [18086781] Nature. 2008 Apr 3;452(7187):633-7 [18385738] Nature. 2008 Apr 3;452(7187):638-42 [18385739] Nat Genet. 2008 May;40(5):616-22 [18385676] Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1127-35 [18483334] Int J Epidemiol. 2008 Jun;37(3):641-53 [18270206] BMC Public Health. 2008;8:203 [18538025] Genome Res. 2012 Sep;22(9):1790-7 [22955989] Science. 2012 Sep 7;337(6099):1190-5 [22955828] Cell. 2012 Sep 14;150(6):1107-20 [22980975] Cell. 2012 Sep 14;150(6):1121-34 [22980976] Nat Genet. 2012 Oct;44(10):1074-5 [23011222] Nature. 2012 Sep 27;489(7417):519-25 [22960745] Hum Mol Genet. 2012 Nov 15;21(22):4980-95 [22899653] PLoS One. 2013;8(2):e56179 [23457522] Hum Genet. 2013 May;132(5):579-89 [23370545] Nat Genet. 2013 Jun;45(6):580-5 [23715323] Nat Genet. 2008 Dec;40(12):1404-6 [18978790] Nat Genet. 2014 Jul;46(7):736-41 [24880342] Genet Epidemiol. 2015 May;39(4):306-16 [25847094] J Clin Oncol. 2008 Jul 20;26(21):3560-6 [18640936] Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3081-9 [18990748] Nat Genet. 2008 Dec;40(12):1407-9 [18978787] Bioinformatics. 2008 Dec 15;24(24):2938-9 [18974171] Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9362-7 [19474294] Genet Epidemiol. 2009 Jan;33(1):79-86 [18642345] J Biol Chem. 2009 Jul 24;284(30):20206-14 [19509291] Am J Hum Genet. 2009 Nov;85(5):679-91 [19836008] Carcinogenesis. 2010 Apr;31(4):625-33 [20106900] Lancet Oncol. 2010 Apr;11(4):321-30 [20304703] BMC Bioinformatics. 2010;11:288 [20509871] BMC Cancer. 2010;10:285 [20546590] Bioinformatics. 2010 Sep 15;26(18):2336-7 [20634204] Cancer Res. 2011 Feb 15;71(4):1356-61 [21303977] CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90 [21296855] Lancet Oncol. 2011 Apr;12(4):399-408 [20951091] PLoS One. 2011;6(4):e14808 [21556132] Nat Genet. 2011 Aug;43(8):792-6 [21725308] Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 [22064851] Carcinogenesis. 2012 Mar;33(3):587-97 [22198214] Cancer Discov. 2012 Feb;2(2):131-9 [22585858] PLoS One. 2012;7(5):e36888 [22662130] Nat Genet. 2012 May;44(5):562-9 [22466613] J Thorac Oncol. 2012 May;7(5):790-8 [22430809] Genome Res. 2012 Sep;22(9):1748-59 [22955986] Cancer. 2002 May 1;94(9):2490-501 [12015775] Nucleic Acids Res. 2003 Jul 1;31(13):3812-4 [12824425] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 [12883005] BMJ. 2003 Sep 6;327(7414):557-60 [12958120] Eur J Hum Genet. 2004 May;12(5):395-9 [14872201] Stat Med. 1993 Apr 30;12(8):717-36 [8516590] Ann Epidemiol. 1994 Jan;4(1):1-10 [8205268] Genome Res. 2005 Aug;15(8):1034-50 [16024819] Genomics. 2005 Nov;86(5):581-93 [16112838] Int J Oncol. 2005 Dec;27(6):1633-45 [16273220] Mutat Res. 2005 Dec 30;592(1-2):147-54 [16054167] Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):639-44 [16614103] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/carcin/bgv128 ER - TY - JOUR T1 - Undocumented status as a social determinant of occupational safety and health: The workers' perspective AN - 1727697654; PQ0002166927 AB - Background Undocumented immigration to the United States has grown dramatically over the past 25 years. This study explores undocumented status as a social determinant of occupational health by examining its perceived consequences on workplace safety of Latino immigrants. Methods Guided by the Theory of Work Adjustment, qualitative analysis was conducted on transcripts from focus groups and individual interviews conducted with a convenience sample of Latino immigrant workers. Results Participants reported that unauthorized status negatively impacted their safety at work and resulted in a degree of alienation that exceeded the specific proscriptions of the law. Participants overwhelming used a strategy of disengagement to cope with the challenges they face as undocumented immigrants. Conclusion This study describes the complex web of consequences resulting from undocumented status and its impact on occupational health. This study presents a framework connecting the daily work experiences of immigrants, the coping strategy of disengagement, and efforts to minimize the impact of structural violence. Am. J. Ind. Med. 58:1127-1137, 2015. JF - American Journal of Industrial Medicine AU - Flynn, Michael A AU - Eggerth, Donald E AU - Jacobson, CJeffrey AD - National Institute for Occupational Safety and Health, Education and Information Division, Cincinnati, Ohio. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1127 EP - 1137 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 11 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Qualitative analysis KW - Immigration KW - Safety KW - Occupational safety KW - Immigrants KW - Violence KW - Workers KW - USA KW - Perception KW - Aggression KW - Ethnic groups KW - Occupational health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727697654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Undocumented+status+as+a+social+determinant+of+occupational+safety+and+health%3A+The+workers%27+perspective&rft.au=Flynn%2C+Michael+A%3BEggerth%2C+Donald+E%3BJacobson%2C+CJeffrey&rft.aulast=Flynn&rft.aufirst=Michael&rft.date=2015-11-01&rft.volume=58&rft.issue=11&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22531 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Workers; Immigration; Immigrants; Aggression; Qualitative analysis; Perception; Occupational safety; Safety; Violence; Ethnic groups; Occupational health; USA DO - http://dx.doi.org/10.1002/ajim.22531 ER - TY - JOUR T1 - Trends of occupational fatalities involving machines, United States, 1992-2010 AN - 1727686389; PQ0002166928 AB - Background This paper describes trends of occupational machine-related fatalities from 1992-2010. We examine temporal patterns by worker demographics, machine types (e.g., stationary, mobile), and industries. Methods We analyzed fatalities from Census of Fatal Occupational Injuries data provided by the Bureau of Labor Statistics to the National Institute for Occupational Safety and Health. We used injury source to identify machine-related incidents and Poisson regression to assess trends over the 19-year period. Results There was an average annual decrease of 2.8% in overall machine-related fatality rates from 1992 through 2010. Mobile machine-related fatality rates decreased an average of 2.6% annually and stationary machine-related rates decreased an average of 3.5% annually. Groups that continued to be at high risk included older workers; self-employed; and workers in agriculture/forestry/fishing, construction, and mining. Conclusion Addressing dangers posed by tractors, excavators, and other mobile machines needs to continue. High-risk worker groups should receive targeted information on machine safety. Am. J. Ind. Med. 58:1160-1173, 2015. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Marsh, Suzanne M AU - Fosbroke, David E AD - National Institute for Occupational Safety and Health, Division of Safety Research, Surveillance and Field Investigations Branch, Morgantown, West Virginia. Y1 - 2015/11// PY - 2015 DA - November 2015 SP - 1160 EP - 1173 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 11 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Agriculture KW - Mortality KW - Statistics KW - Data processing KW - Injuries KW - Occupational safety KW - Safety KW - Demography KW - Fishing KW - Workers KW - USA KW - Risk factors KW - Risk groups KW - Census KW - Agricultural equipment KW - Forestry KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727686389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Trends+of+occupational+fatalities+involving+machines%2C+United+States%2C+1992-2010&rft.au=Marsh%2C+Suzanne+M%3BFosbroke%2C+David+E&rft.aulast=Marsh&rft.aufirst=Suzanne&rft.date=2015-11-01&rft.volume=58&rft.issue=11&rft.spage=1160&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22532 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Agriculture; Demography; Workers; Data processing; Statistics; Injuries; Risk factors; Risk groups; Census; Forestry; Risk assessment; Fishing; Mortality; Safety; Occupational safety; Agricultural equipment; USA DO - http://dx.doi.org/10.1002/ajim.22532 ER - TY - JOUR T1 - MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells. AN - 1721632942; 26296572 AB - Cytochrome P450 2C19 (CYP2C19) is involved in the metabolism of many drugs. Extensive studies have demonstrated that genetic variants and endogenous and environmental factors play important roles in the expression of CYP2C19. However, the role of microRNAs (miRNAs) in controlling CYP2C19 expression has not been investigated completely. In the present study, we performed in silico analysis to rank putative miRNA/CYP2C19 hybrids with regards to the predicted stabilities of their duplexes and then we applied a series of biochemical and molecular assays to elucidate the underlying functional mechanisms for the regulation of CYP2C19 by miRNAs. In silico analysis indicated that hsa-miR-23a-3p and hsa-miR-29a-3p target the coding region of CYP2C19 with hybrid stabilities of -27.5kcal/mol and -23.3kcal/mol, respectively. RNA electrophoresis mobility shift assays showed that both hsa-miR-23a-3p and hsa-miR-29a-3p miRNAs were able to bind directly to their cognate targets in the CYP2C19 transcript. Further, a significant inverse correlation was found between chemically-induced up-regulation of hsa-miR-29a-3p and CYP2C19 expression in HepaRG cells. In addition, inverse correlations were also observed in human liver tissue samples between the level of CYP2C19 mRNA expression and both hsa-miR-23a-3p and hsa-miR-29a-3p levels. All these results demonstrated the suppressing role of hsa-miR-29a-3p on CYP2C19 expression. Published by Elsevier Inc. JF - Biochemical pharmacology AU - Yu, Dianke AU - Green, Bridgett AU - Tolleson, William H AU - Jin, Yaqiong AU - Mei, Nan AU - Guo, Yongli AU - Deng, Helen AU - Pogribny, Igor AU - Ning, Baitang AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China. ; Arkansas Department of Health, Little Rock, AR 72205, USA. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: baitang.ning@fda.hhs.gov. Y1 - 2015/11/01/ PY - 2015 DA - 2015 Nov 01 SP - 215 EP - 223 VL - 98 IS - 1 KW - MIRN29 microRNA, human KW - 0 KW - MicroRNAs KW - CYP2C19 protein, human KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP2C19 KW - Index Medicus KW - Pharmacogenomics KW - CYP2C19 KW - Drug metabolizing enzymes KW - hsa-miR-29a-3p KW - microRNA KW - Inter-individual variability KW - Humans KW - Kidney -- embryology KW - Cell Line KW - MicroRNAs -- metabolism KW - Gene Expression Regulation -- physiology KW - Cytochrome P-450 CYP2C19 -- metabolism KW - MicroRNAs -- genetics KW - Cytochrome P-450 CYP2C19 -- genetics KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1721632942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=MicroRNA+hsa-miR-29a-3p+modulates+CYP2C19+in+human+liver+cells.&rft.au=Yu%2C+Dianke%3BGreen%2C+Bridgett%3BTolleson%2C+William+H%3BJin%2C+Yaqiong%3BMei%2C+Nan%3BGuo%2C+Yongli%3BDeng%2C+Helen%3BPogribny%2C+Igor%3BNing%2C+Baitang&rft.aulast=Yu&rft.aufirst=Dianke&rft.date=2015-11-01&rft.volume=98&rft.issue=1&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2015.08.094 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-09 N1 - Date created - 2015-10-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcp.2015.08.094 ER - TY - CPAPER T1 - Healthy People 2020: Laying the foundation for addressing social determinants of health and health equity T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772200; 6365816 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Blakey, Carter Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Healthy+People+2020%3A+Laying+the+foundation+for+addressing+social+determinants+of+health+and+health+equity&rft.au=Blakey%2C+Carter&rft.aulast=Blakey&rft.aufirst=Carter&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - I Can Do It, You Can Do It!: Empowering People with Disabilities to Lead Healthy, Active Lives T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772168; 6365063 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Darensbourg, Lauren Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Disabilities UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=I+Can+Do+It%2C+You+Can+Do+It%21%3A+Empowering+People+with+Disabilities+to+Lead+Healthy%2C+Active+Lives&rft.au=Darensbourg%2C+Lauren&rft.aulast=Darensbourg&rft.aufirst=Lauren&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Does Partner Support Improve Pregnancy Outcomes for Mistimed Births among Black Teen Mothers? T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772109; 6367885 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Cai, Beiyi AU - Banerjee, Deborah Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Birth KW - Parturition KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Does+Partner+Support+Improve+Pregnancy+Outcomes+for+Mistimed+Births+among+Black+Teen+Mothers%3F&rft.au=Cai%2C+Beiyi%3BBanerjee%2C+Deborah&rft.aulast=Cai&rft.aufirst=Beiyi&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Cervical cancer screening rates outcomes in federally funded community health centers through patient-centered medical home transformation T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731772106; 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6365443 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Lier, Silje AU - Rider, Briana Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Diabetes mellitus KW - Learning KW - Education KW - Drugs KW - Internet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731772041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Online+Learning+for+Providers%3A+Teaching+patient-centered+health+literacy+strategies+for+individualizing+care+among+patients+with+diabetes+to+prevent+adverse+drug+events&rft.au=Lier%2C+Silje%3BRider%2C+Briana&rft.aulast=Lier&rft.aufirst=Silje&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Maternal, Infant and Early Childhood Home Visiting Program: Evidence-based home visiting programs and the Role of Home Visitors T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771695; 6367942 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Kilbane, Kathleen Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Children KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Maternal%2C+Infant+and+Early+Childhood+Home+Visiting+Program%3A+Evidence-based+home+visiting+programs+and+the+Role+of+Home+Visitors&rft.au=Kilbane%2C+Kathleen&rft.aulast=Kilbane&rft.aufirst=Kathleen&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - A Method to Improve Population Health: Consider Primary Care/Public Health Integration T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771410; 6367798 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Culver, Martha AU - Jackson, Princess Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Integration KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=A+Method+to+Improve+Population+Health%3A+Consider+Primary+Care%2FPublic+Health+Integration&rft.au=Culver%2C+Martha%3BJackson%2C+Princess&rft.aulast=Culver&rft.aufirst=Martha&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Teaching Self-efficacy in Managing Disease: A Healthcare Cost Cutting Measure T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731771237; 6365789 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Selexman, LaTosha AU - Cai, Beiyi Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Education KW - Health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731771237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Teaching+Self-efficacy+in+Managing+Disease%3A+A+Healthcare+Cost+Cutting+Measure&rft.au=Selexman%2C+LaTosha%3BCai%2C+Beiyi&rft.aulast=Selexman&rft.aufirst=LaTosha&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Real Cost: The U.S. Food and Drug Administration's Youth Tobacco Prevention Campaign T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731769426; 6364831 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Crosby, Kathleen Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Prevention KW - Tobacco KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731769426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Deciphering+the+underlying+mechanisms+of+oxidation-state+dependent+cytotoxicity+of+graphene+oxide+on+mammalian+cells.&rft.au=Zhang%2C+Wendi%3BYan%2C+Liang%3BLi%2C+Meng%3BZhao%2C+Ruisheng%3BYang%2C+Xiao%3BJi%2C+Tianjiao%3BGu%2C+Zhanjun%3BYin%2C+Jun-Jie%3BGao%2C+Xingfa%3BNie%2C+Guangjun&rft.aulast=Zhang&rft.aufirst=Wendi&rft.date=2015-09-02&rft.volume=237&rft.issue=2&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2015.05.021 L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - National Viral Hepatitis Action Plan T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731768404; 6366762 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Dan, Corinna Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Hepatitis A UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731768404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=National+Viral+Hepatitis+Action+Plan&rft.au=Dan%2C+Corinna&rft.aulast=Dan&rft.aufirst=Corinna&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Implementation of Telehealth among Behavioral Health Providers Serving Rural and Hard to Reach Populations T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731768227; 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6367487 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Ochiai, Emmeline AU - Roper, Allison Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Policies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731766825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Developing+Healthy+People+2030%3A+Engaging+Multiple+Partners+and+Influencing+Policy&rft.au=Ochiai%2C+Emmeline%3BRoper%2C+Allison&rft.aulast=Ochiai&rft.aufirst=Emmeline&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Healthy People 2020 and Social Determinants of Health: Eliminating Barriers to and Improving Social Determinants of Health T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731766792; 6367485 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Ochiai, Emmeline Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Barriers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731766792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Healthy+People+2020+and+Social+Determinants+of+Health%3A+Eliminating+Barriers+to+and+Improving+Social+Determinants+of+Health&rft.au=Ochiai%2C+Emmeline&rft.aulast=Ochiai&rft.aufirst=Emmeline&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Addressing social determinants to achieve health equity: A regional perspective T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731765684; 6365817 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Lando, James Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731765684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Addressing+social+determinants+to+achieve+health+equity%3A+A+regional+perspective&rft.au=Lando%2C+James&rft.aulast=Lando&rft.aufirst=James&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Health Disparity Data Tool: An innovative instrument to explore health disparities with DATA2020 T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731765507; 6366333 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Wendt, Minh AU - Hoyer, Deborah AU - Dorsey, Rashida Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Data processing KW - Innovations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731765507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Health+Disparity+Data+Tool%3A+An+innovative+instrument+to+explore+health+disparities+with+DATA2020&rft.au=Wendt%2C+Minh%3BHoyer%2C+Deborah%3BDorsey%2C+Rashida&rft.aulast=Wendt&rft.aufirst=Minh&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - San Diego County's Live Well @ Work Initiative: Advancing Employee Health through Policy, Systems and Environmental Change T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731765496; 6365748 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Blevins, Chesley AU - Thompson, Kelley AU - Melendrez, Blanca AU - Browner, Deirdre AU - McDermid, Lindsey AU - Wooten, Wilma AU - Coleman, Thomas Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Policies KW - Personnel KW - Climatic changes KW - Environmental changes KW - USA, California, San Diego Cty. 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6366330 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Ejike-King, Lacreisha AU - Dorsey, Rashida Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Health care KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731765467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=An+Assessment+of+the+Implementation+of+the+National+Standards+for+Culturally+and+Linguistically+Appropriate+Services+in+Health+and+Health+Care+within+the+U.S.+Department+of+Health+and+Human+Services&rft.au=Ejike-King%2C+Lacreisha%3BDorsey%2C+Rashida&rft.aulast=Ejike-King&rft.aufirst=Lacreisha&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - SOAR to Health and Wellness: A New Federal Training on Human Trafficking for Health Care Providers T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764862; 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6367452 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Ridl, Sophia AU - Retzer, Kyla AU - Hill, Ryan Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Mortality KW - Oil and gas industry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731764782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Development+of+an+Oil+and+Gas+Worker+Fatality+Surveillance+System&rft.au=Ridl%2C+Sophia%3BRetzer%2C+Kyla%3BHill%2C+Ryan&rft.aulast=Ridl&rft.aufirst=Sophia&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Developing Informatics Tools for the Evaluation of Large Health Data Sets T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731764762; 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6364898 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Hernandez, Rocio AU - Rockas, Theresa Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Policies KW - Social interactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731762999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Healthy+Fun+for+All+Festivals%3A+Policy+for+Social+Norms+Change&rft.au=Hernandez%2C+Rocio%3BRockas%2C+Theresa&rft.aulast=Hernandez&rft.aufirst=Rocio&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Developing and Administering a Health Survey in the Asian Indian Community in Houston T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731762701; 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6366795 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Abbey, Rachel Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Disasters KW - Information exchange UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731762627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Using+a+Disaster+Event+as+a+Use+Case+for+Health+Information+Exchange&rft.au=Abbey%2C+Rachel&rft.aulast=Abbey&rft.aufirst=Rachel&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Spatial Analysis of Community HIV Viral Loads in an Urban Setting T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760443; 6366800 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Zhou, Weilin Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Human immunodeficiency virus KW - Spatial analysis KW - Urban areas UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Spatial+Analysis+of+Community+HIV+Viral+Loads+in+an+Urban+Setting&rft.au=Zhou%2C+Weilin&rft.aulast=Zhou&rft.aufirst=Weilin&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Accreditation Documentation Management System (ADMS) T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760265; 6366782 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Coker, Ololade AU - Hines, Robert AU - Olumuyiwa, Tolulope AU - Arafat, Raouf Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Accreditation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Accreditation+Documentation+Management+System+%28ADMS%29&rft.au=Coker%2C+Ololade%3BHines%2C+Robert%3BOlumuyiwa%2C+Tolulope%3BArafat%2C+Raouf&rft.aulast=Coker&rft.aufirst=Ololade&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Surgical Smoke and Healthcare Worker Health and Safety T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760173; 6367207 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Steege, Andrea AU - Boiano, Jim AU - Haring Sweeney, Marie Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Smoke KW - Surgery KW - Safety KW - Health and safety KW - Medical personnel UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Surgical+Smoke+and+Healthcare+Worker+Health+and+Safety&rft.au=Steege%2C+Andrea%3BBoiano%2C+Jim%3BHaring+Sweeney%2C+Marie&rft.aulast=Steege&rft.aufirst=Andrea&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Association between Health Care Access Quality Indicators and Emergency Department Use among Children with Developmental Disabilities in the US T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760146; 6367059 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Chienshy Lin, Sue Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Health care KW - Disabilities KW - Emergencies KW - Children KW - Emergency medical services UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Association+between+Health+Care+Access+Quality+Indicators+and+Emergency+Department+Use+among+Children+with+Developmental+Disabilities+in+the+US&rft.au=Chienshy+Lin%2C+Sue&rft.aulast=Chienshy+Lin&rft.aufirst=Sue&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - Mental health professionals' attitude and perception of their role in tackling substance abuse and related disorders in Nigeria T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760145; 6367142 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Akinola, Olubusayo AU - Kuo, Wen-Hung AU - Oswald, John AU - Fulton, Lawrence AU - Obisesan, Olawunmi Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Mental disorders KW - Attitudes KW - Nigeria KW - Perception KW - Experts KW - Drug abuse KW - Substance abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Mental+health+professionals%27+attitude+and+perception+of+their+role+in+tackling+substance+abuse+and+related+disorders+in+Nigeria&rft.au=Akinola%2C+Olubusayo%3BKuo%2C+Wen-Hung%3BOswald%2C+John%3BFulton%2C+Lawrence%3BObisesan%2C+Olawunmi&rft.aulast=Akinola&rft.aufirst=Olubusayo&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - CPAPER T1 - National Institute for Occupational Safety and Health (NIOSH) Oil and Gas Extraction Safety and Health Program: Lessons in How Partnerships Drive Quality Research T2 - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AN - 1731760136; 6367449 JF - 143rd American Public Health Association Annual Meeting and Exposition (APHA 2015) AU - Alexander-Scott, Marissa Y1 - 2015/10/31/ PY - 2015 DA - 2015 Oct 31 KW - Oil and gas industry KW - Occupational safety KW - Safety KW - Health and safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1731760136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=National+Institute+for+Occupational+Safety+and+Health+%28NIOSH%29+Oil+and+Gas+Extraction+Safety+and+Health+Program%3A+Lessons+in+How+Partnerships+Drive+Quality+Research&rft.au=Alexander-Scott%2C+Marissa&rft.aulast=Alexander-Scott&rft.aufirst=Marissa&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ L2 - https://apha.confex.com/apha/143am/webprogram/meeting.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-06 N1 - Last updated - 2015-11-09 ER - TY - JOUR T1 - The commensal infant gut meta-mobilome as a potential reservoir for persistent multidrug resistance integrons. AN - 1728256516; 26507767 AB - Despite the accumulating knowledge on the development and establishment of the gut microbiota, its role as a reservoir for multidrug resistance is not well understood. This study investigated the prevalence and persistence patterns of an integrase gene (int1), used as a proxy for integrons (which often carry multiple antimicrobial resistance genes), in the fecal microbiota of 147 mothers and their children sampled longitudinally from birth to 2 years. The study showed the int1 gene was detected in 15% of the study population, and apparently more persistent than the microbial community structure itself. We found int1 to be persistent throughout the first two years of life, as well as between mothers and their 2-year-old children. Metagenome sequencing revealed integrons in the gut meta-mobilome that were associated with plasmids and multidrug resistance. In conclusion, the persistent nature of integrons in the infant gut microbiota makes it a potential reservoir of mobile multidrug resistance. JF - Scientific reports AU - Ravi, Anuradha AU - Avershina, Ekaterina AU - Foley, Steven L AU - Ludvigsen, Jane AU - Storrø, Ola AU - Øien, Torbjørn AU - Johnsen, Roar AU - McCartney, Anne L AU - L'Abée-Lund, Trine M AU - Rudi, Knut AD - Norwegian University of Life Sciences, Chemistry, Biotechnology and Food science department (IKBM), Campus Ås, Ås 1432, Norway. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Division of Microbiology, Jefferson, AR 72079. ; Department of Public Health and General Practice, Norwegian University of Science and Technology, 9491 Trondheim, Norway. ; Microbial Ecology &Health Group, Department of Food and Nutritional Sciences, University of Reading, Reading, UK. ; Norwegian University of Life Sciences, Department of Food safety and Infection Biology, Campus Adamstuen, Oslo 0454, Norway. Y1 - 2015/10/28/ PY - 2015 DA - 2015 Oct 28 SP - 15317 VL - 5 KW - DNA, Bacterial KW - 0 KW - Integrases KW - EC 2.7.7.- KW - Index Medicus KW - Infant KW - Humans KW - Infant, Newborn KW - Bacterial Physiological Phenomena KW - Female KW - Pregnancy KW - Bacteria -- metabolism KW - Bacteria -- genetics KW - Symbiosis KW - Integrons KW - Drug Resistance, Multiple, Bacterial -- genetics KW - Integrases -- genetics KW - Gastrointestinal Tract -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1728256516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=The+commensal+infant+gut+meta-mobilome+as+a+potential+reservoir+for+persistent+multidrug+resistance+integrons.&rft.au=Ravi%2C+Anuradha%3BAvershina%2C+Ekaterina%3BFoley%2C+Steven+L%3BLudvigsen%2C+Jane%3BStorr%C3%B8%2C+Ola%3B%C3%98ien%2C+Torbj%C3%B8rn%3BJohnsen%2C+Roar%3BMcCartney%2C+Anne+L%3BL%27Ab%C3%A9e-Lund%2C+Trine+M%3BRudi%2C+Knut&rft.aulast=Ravi&rft.aufirst=Anuradha&rft.date=2015-10-28&rft.volume=5&rft.issue=&rft.spage=15317&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep15317 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-17 N1 - Date created - 2015-10-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: PLoS One. 2011;6(6):e21644 [21738748] Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33 [20805405] Nature. 2011 Dec 8;480(7376):241-4 [22037308] Bioinformatics. 2012 Jun 15;28(12):1647-9 [22543367] Nature. 2012 Jun 14;486(7402):222-7 [22699611] Genome Res. 2012 Oct;22(10):1985-94 [22732228] Appl Environ Microbiol. 2013 Jan;79(2):497-507 [23124244] PLoS One. 2013;8(2):e57923 [23460914] Science. 2013 Jul 5;341(6141):1237439 [23828941] BMC Bioinformatics. 2008;9:386 [18803844] Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):652-7 [11209061] Mol Microbiol. 2001 Nov;42(3):587-601 [11722728] Microbiology. 2002 Jan;148(Pt 1):257-66 [11782518] Antimicrob Agents Chemother. 2003 Apr;47(4):1285-90 [12654659] Clin Microbiol Infect. 2004 Apr;10(4):272-88 [15059115] Proc Natl Acad Sci U S A. 2004 May 4;101(18):7118-22 [15107498] FEMS Microbiol Lett. 1998 Apr 1;161(1):125-8 [9561739] Biotechnol Bioeng. 2005 Mar 20;89(6):670-9 [15696537] Curr Microbiol. 2005 Oct;51(4):270-4 [16187156] Appl Environ Microbiol. 2006 Jul;72(7):5069-72 [16820507] Nat Rev Microbiol. 2006 Aug;4(8):608-20 [16845431] Nature. 2013 Jul 11;499(7457):219-22 [23748443] Nat Commun. 2013;4:2151 [23877117] Benef Microbes. 2013 Sep;4(3):219-22 [23887030] Nature. 2013 Jul 25;499(7459):394-6 [23887414] PLoS One. 2013;8(11):e78822 [24236055] Nucleic Acids Res. 2014 Jan;42(Database issue):D581-91 [24225323] FEMS Microbiol Ecol. 2014 Jan;87(1):280-90 [24112053] ISME J. 2015 Jun;9(6):1269-79 [25500508] Trends Microbiol. 2007 Jul;15(7):301-9 [17566739] Antimicrob Agents Chemother. 2000 May;44(5):1315-21 [10770768] ISME J. 2009 Feb;3(2):209-15 [18923456] PLoS Biol. 2007 Jul;5(7):e177 [17594176] Science. 2009 Aug 28;325(5944):1128-31 [19713526] Ann Clin Microbiol Antimicrob. 2009;8:34 [19995422] Nat Methods. 2010 May;7(5):335-6 [20383131] Physiol Rev. 2010 Jul;90(3):859-904 [20664075] Int J Food Microbiol. 2011 Oct 3;149(3):274-7 [21802160] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep15317 ER - TY - JOUR T1 - Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. AN - 1727993183; 26499117 AB - Exposure to dichlorvos (DDVP), an organophosphorus pesticide, is known to result in neurotoxicity as well as other metabolic perturbations. However, the molecular causes of DDVP toxicity are poorly understood, especially in cells other than neurons and muscle cells. To obtain a better understanding of the process of non-neuronal DDVP toxicity, we exposed zebrafish to different concentrations of DDVP, and investigated the resulting changes in liver histology and gene transcription. Functional enrichment analysis of genes affected by DDVP exposure identified a number of processes involved in energy utilization and stress response in the liver. The abundance of transcripts for proteins involved in glucose metabolism was profoundly affected, suggesting that carbon flux might be diverted toward the pentose phosphate pathway to compensate for an elevated demand for energy and reducing equivalents for detoxification. Strikingly, many transcripts for molecules involved in β-oxidation and fatty acid synthesis were down-regulated. We found increases in message levels for molecules involved in reactive oxygen species responses as well as ubiquitination, proteasomal degradation, and autophagy. To ensure that the effects of DDVP on energy metabolism were not simply a consequence of poor feeding because of neuromuscular impairment, we fasted fish for 29 or 50 h and analyzed liver gene expression in them. The patterns of gene expression for energy metabolism in fasted and DDVP-exposed fish were markedly different. We observed coordinated changes in the expression of a large number of genes involved in energy metabolism and responses to oxidative stress. These results argue that an appreciable part of the effect of DDVP is on energy metabolism and is regulated at the message level. Although we observed some evidence of neuromuscular impairment in exposed fish that may have resulted in reduced feeding, the alterations in gene expression in exposed fish cannot readily be explained by nutrient deprivation. JF - BMC genomics AU - Bui-Nguyen, Tri M AU - Baer, Christine E AU - Lewis, John A AU - Yang, Dongren AU - Lein, Pamela J AU - Jackson, David A AD - ORISE Postdoctoral Fellow, Fort Detrick, MD, 21702, USA. Tri.Bui-Nguyen@fda.hhs.gov. ; Excet, Inc., Springfield, VA, 22151, USA. christine.e.baer2.ctr@mail.mil. ; US Army Center for Environmental Health Research, Fort Detrick, MD, 21702, USA. john.a.lewis5.civ@mail.mil. ; Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, 95616, USA. mryang@ucdavis.edu. ; Molecular Biosciences, School of Veterinary Medicine, University of California Davis, Davis, CA, 95616, USA. pjlein@ucdavis.edu. ; US Army Center for Environmental Health Research, Fort Detrick, MD, 21702, USA. david.a.jackson17.civ@mail.mil. Y1 - 2015/10/24/ PY - 2015 DA - 2015 Oct 24 SP - 853 VL - 16 KW - Insecticides KW - 0 KW - Reactive Oxygen Species KW - Dichlorvos KW - 7U370BPS14 KW - Cholinesterases KW - EC 3.1.1.8 KW - Index Medicus KW - Animals KW - Reactive Oxygen Species -- metabolism KW - Lipid Metabolism -- genetics KW - Models, Biological KW - Carbohydrate Metabolism -- genetics KW - Cholinesterases -- metabolism KW - Gene Expression Profiling KW - Apoptosis -- genetics KW - Unfolded Protein Response KW - Signal Transduction -- drug effects KW - Enzyme Activation -- drug effects KW - Oxidative Stress -- drug effects KW - Gene Expression Regulation -- drug effects KW - Cluster Analysis KW - Insecticides -- toxicity KW - Liver -- pathology KW - Zebrafish -- metabolism KW - Liver -- drug effects KW - Dichlorvos -- toxicity KW - Energy Metabolism -- drug effects KW - Energy Metabolism -- genetics KW - Liver -- metabolism KW - Zebrafish -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727993183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Dichlorvos+exposure+results+in+large+scale+disruption+of+energy+metabolism+in+the+liver+of+the+zebrafish%2C+Danio+rerio.&rft.au=Bui-Nguyen%2C+Tri+M%3BBaer%2C+Christine+E%3BLewis%2C+John+A%3BYang%2C+Dongren%3BLein%2C+Pamela+J%3BJackson%2C+David+A&rft.aulast=Bui-Nguyen&rft.aufirst=Tri&rft.date=2015-10-24&rft.volume=16&rft.issue=&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2Fs12864-015-1941-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-30 N1 - Date created - 2015-10-27 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - GSE66257; GEO N1 - SuppNotes - Cited By: J Cell Biol. 2008 Aug 25;182(4):663-73 [18725537] Physiol Biochem Zool. 2008 Nov-Dec;81(6):762-74 [18947325] Physiol Genomics. 2008 Nov 12;35(3):283-95 [18728227] Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20567-74 [19074260] J Immunol. 2009 Apr 15;182(8):4917-30 [19342671] Mutagenesis. 2009 May;24(3):211-24 [19153097] Toxicology. 2010 Apr 11;270(2-3):77-84 [20132858] Genes Cells. 2010 Sep 1;15(9):923-33 [20670274] Pathol Res Pract. 2010 Sep 15;206(9):631-41 [20591579] Indian J Exp Biol. 2010 Jul;48(7):697-709 [20929053] Mol Brain. 2010;3:35 [21073741] Science. 2010 Dec 3;330(6009):1344-8 [21127245] Toxicol Sci. 2011 Oct;123(2):590-600 [21775727] Biochem J. 1986 Jun 15;236(3):635-41 [3790084] Exp Parasitol. 1991 May;72(4):355-61 [2026213] Exp Mol Pathol. 1992 Apr;56(2):144-52 [1587340] Toxicol Appl Pharmacol. 1992 Aug;115(2):268-77 [1641860] Pancreas. 1993 Mar;8(2):171-5 [8460092] Mech Dev. 1997 Jul;65(1-2):87-98 [9256347] Gene. 1997 Nov 12;201(1-2):87-98 [9409775] Pharmacol Biochem Behav. 1998 Apr;59(4):1081-6 [9586870] Mol Cell Biol. 1999 Oct;19(10):6825-32 [10490621] Biochem J. 1999 Oct 15;343 Pt 2:487-504 [10510318] Bull Environ Contam Toxicol. 1981 Apr;26(4):453-60 [7236904] Bull Environ Contam Toxicol. 1981 Apr;26(4):496-501 [6786400] J Biol Chem. 1983 Mar 10;258(5):2993-9 [6402507] Environ Res. 1983 Oct;32(1):127-33 [6617605] Am J Physiol. 1957 Feb;188(2):321-6 [13411209] Biochem Pharmacol. 1961 Jul;7:88-95 [13726518] Biochim Biophys Acta. 2004 Nov 29;1695(1-3):171-88 [15571814] Biochem J. 2005 Sep 1;390(Pt 2):521-8 [15890065] Gene. 2005 Aug 15;356:91-100 [15979250] Life Sci. 2006 Jan 25;78(9):1015-20 [16153661] Mol Cell Biol. 2006 Feb;26(3):940-54 [16428448] Regul Toxicol Pharmacol. 2006 Apr;44(3):238-48 [16439043] Physiol Genomics. 2006 Nov 27;27(3):351-61 [16882884] Mol Cell Biochem. 2002 Mar;232(1-2):13-8 [12030370] Am J Physiol Cell Physiol. 2003 Oct;285(4):C806-12 [12773310] Aquat Toxicol. 2003 Dec 10;65(4):337-60 [14568351] Nephrol Nurs J. 2003 Dec;30(6):621-6; 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AN - 1717472907; 25620055 AB - Extensive first-pass metabolism of ingested bisphenol A (BPA) in the gastro-intestinal tract and liver restricts blood concentrations of bioactive BPA to <1% of total BPA in humans and non-human primates. Absorption of ingested BPA through non-metabolizing tissues of the oral cavity, recently demonstrated in dogs, could lead to the higher serum BPA concentrations reported in some human biomonitoring studies. We hypothesized that the extensive interaction with the oral mucosa by a liquid matrix, like soup, relative to solid food or capsules, might enhance absorption through non-metabolizing oral cavity tissues in humans, producing higher bioavailability and higher serum BPA concentrations. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a 24hour period in 10 adult male volunteers following ingestion of 30μg d6-BPA/kg body weight in soup. Absorption of d6-BPA was rapid (t1/2=0.45h) and elimination of the administered dose was complete 24h post-ingestion, evidence against any tissue depot for BPA. The maximum serum d6-BPA concentration was 0.43nM at 1.6h after administration and represented <0.3% of total d6-BPA. Pharmacokinetic parameters, pharmacokinetic model simulations, and the significantly faster appearance half-life of d6-BPA-glucuronide compared to d6-BPA (0.29h vs 0.45h) were evidence against meaningful absorption of BPA in humans through any non-metabolizing tissue (<1%). This study confirms that typical exposure to BPA in food produces picomolar to subpicomolar serum BPA concentrations in humans, not nM concentrations reported in some biomonitoring studies. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Teeguarden, Justin G AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Yang, Xiaoxia AU - Fisher, Jeffrey W AU - Seryak, Liesel M AU - Doerge, Daniel R AD - Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99352, USA; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 93771, USA. Electronic address: jt@pnl.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: nathan.twaddle@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: mona.churchwell@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: xiaoxia.yang@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: jeffrey.fisher@fda.hhs.gov. ; Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH 43210, USA. Electronic address: seryak.2@osu.edu. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: daniel.doerge@fda.hhs.gov. Y1 - 2015/10/15/ PY - 2015 DA - 2015 Oct 15 SP - 131 EP - 142 VL - 288 IS - 2 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Glucuronides KW - Phenols KW - Sulfates KW - bisphenol A glucuronide KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Bisphenol A KW - Oral KW - Sublingual KW - Exposure KW - Endocrine disruptors KW - Pharmacokinetics KW - Administration, Oral KW - Young Adult KW - Humans KW - Metabolic Clearance Rate KW - Models, Biological KW - Renal Elimination KW - Half-Life KW - Biotransformation KW - Sulfates -- blood KW - Adult KW - Middle Aged KW - Sulfates -- urine KW - Glucuronides -- blood KW - Glucuronides -- urine KW - Male KW - Phenols -- administration & dosage KW - Endocrine Disruptors -- blood KW - Benzhydryl Compounds -- pharmacokinetics KW - Phenols -- blood KW - Phenols -- pharmacokinetics KW - Food Contamination KW - Endocrine Disruptors -- urine KW - Benzhydryl Compounds -- blood KW - Endocrine Disruptors -- pharmacokinetics KW - Endocrine Disruptors -- administration & dosage KW - Phenols -- urine KW - Oral Mucosal Absorption KW - Mouth Mucosa -- metabolism KW - Benzhydryl Compounds -- administration & dosage KW - Benzhydryl Compounds -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717472907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=24-hour+human+urine+and+serum+profiles+of+bisphenol+A%3A+Evidence+against+sublingual+absorption+following+ingestion+in+soup.&rft.au=Teeguarden%2C+Justin+G%3BTwaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BYang%2C+Xiaoxia%3BFisher%2C+Jeffrey+W%3BSeryak%2C+Liesel+M%3BDoerge%2C+Daniel+R&rft.aulast=Teeguarden&rft.aufirst=Justin&rft.date=2015-10-15&rft.volume=288&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.01.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-13 N1 - Date created - 2015-09-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.01.009 ER - TY - JOUR T1 - Occupational characteristics and the progression of carotid artery intima-media thickness and plaque over 9years: the Multi-Ethnic Study of Atherosclerosis (MESA) AN - 1808709175; PQ0003421142 AB - ObjectivesThe role of occupation in the development of cardiovascular disease (CVD) remains a topic of research because few studies have examined longitudinal associations, and because occupation can be an indicator of socioeconomic position (SEP) and a proxy for hazard exposure. This study examines associations of occupational category as an SEP marker and selected occupational exposures with progression of the subclinical carotid artery disease.MethodsA community-based, multiethnic sample (n=3109, mean age=60.2) provided subclinical CVD measures at least twice at three data collection points (mean follow-up=9.4years). After accounting for demographic characteristics, SEP, and traditional CVD risk factors, we modelled common carotid intima-media thickness, carotid plaque scores, and carotid plaque shadowing as a function of occupational category, physical hazard exposure, physical activity on the job, interpersonal stress, job control and job demands. These job characteristics were derived from the Occupational Resource Network (O*NET). Random coefficient models were used to account for repeated measures and time-varying covariates.ResultsThere were a few statistically significant associations at baseline. After all covariates were included in the model, men in management, office/sales, service and blue-collar jobs had 28-44% higher plaque scores than professionals at baseline (p=0.001). Physically hazardous jobs were positively associated with plaque scores among women (p=0.014). However, there were no significant longitudinal associations between any of the occupational characteristics and any of the subclinical CVD measures.ConclusionsThere was little evidence that the occupational characteristics examined in this study accelerated the progression of subclinical CVD. JF - Occupational and Environmental Medicine AU - Fujishiro, Kaori AU - Diez Roux, Ana V AU - Landsbergis, Paul AU - Kaufman, Joel D AU - Korcarz, Claudia E AU - Stein, James H AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/10/12/ PY - 2015 DA - 2015 Oct 12 SP - 690 EP - 698 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 72 IS - 10 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Data collection KW - Community involvement KW - Physical activity KW - Statistical analysis KW - Stress KW - Socioeconomics KW - Data collections KW - Arteriosclerosis KW - Models KW - Demography KW - Somatosensory evoked potentials KW - Socio-economic aspects KW - Risk factors KW - Carotid artery KW - Mesas KW - Plaques KW - Cardiovascular diseases KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808709175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Occupational+characteristics+and+the+progression+of+carotid+artery+intima-media+thickness+and+plaque+over+9years%3A+the+Multi-Ethnic+Study+of+Atherosclerosis+%28MESA%29&rft.au=Fujishiro%2C+Kaori%3BDiez+Roux%2C+Ana+V%3BLandsbergis%2C+Paul%3BKaufman%2C+Joel+D%3BKorcarz%2C+Claudia+E%3BStein%2C+James+H&rft.aulast=Fujishiro&rft.aufirst=Kaori&rft.date=2015-10-12&rft.volume=72&rft.issue=10&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102311 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Physical activity; Statistical analysis; Arteriosclerosis; Data collections; Models; Somatosensory evoked potentials; Demography; Socio-economic aspects; Risk factors; Carotid artery; Plaques; Cardiovascular diseases; Occupational exposure; Data collection; Community involvement; Socioeconomics; Stress; Mesas DO - http://dx.doi.org/10.1136/oemed-2014-102311 ER - TY - JOUR T1 - Exposure-response relationships for select cancer and non-cancer health outcomes in a cohort of US firefighters from San Francisco, Chicago and Philadelphia (1950-2009) AN - 1808617203; PQ0003421143 AB - ObjectivesTo examine exposure-response relationships between surrogates of firefighting exposure and select outcomes among previously studied US career firefighters.MethodsEight cancer and four non-cancer outcomes were examined using conditional logistic regression. Incidence density sampling was used to match each case to 200 controls on attained age. Days accrued in firefighting assignments (exposed-days), run totals (fire-runs) and run times (fire-hours) were used as exposure surrogates. HRs comparing 75th and 25th centiles of lagged cumulative exposures were calculated using loglinear, linear, log-quadratic, power and restricted cubic spline general relative risk models. Piecewise constant models were used to examine risk differences by time since exposure, age at exposure and calendar period.ResultsAmong 19309 male firefighters eligible for the study, there were 1333 cancer deaths and 2609 cancer incidence cases. Significant positive associations between fire-hours and lung cancer mortality and incidence were evident. A similar relation between leukaemia mortality and fire-runs was also found. The lung cancer associations were nearly linear in cumulative exposure, while the association with leukaemia mortality was attenuated at higher exposure levels and greater for recent exposures. Significant negative associations were evident for the exposure surrogates and colorectal and prostate cancers, suggesting a healthy worker survivor effect possibly enhanced by medical screening.ConclusionsLung cancer and leukaemia mortality risks were modestly increasing with firefighter exposures. These findings add to evidence of a causal association between firefighting and cancer. Nevertheless, small effects merit cautious interpretation. We plan to continue to follow the occurrence of disease and injury in this cohort. JF - Occupational and Environmental Medicine AU - Daniels, Robert D AU - Bertke, Stephen AU - Dahm, Matthew M AU - Yiin, James H AU - Kubale, Travis L AU - Hales, Thomas R AU - Baris, Dalsu AU - Zahm, Shelia H AU - Beaumont, James J AU - Waters, Kathleen M AU - Pinkerton, Lynne E AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/10/11/ PY - 2015 DA - 2015 Oct 11 SP - 699 EP - 706 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 72 IS - 10 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - USA, Illinois, Chicago KW - Risk assessment KW - Age KW - Injuries KW - Models KW - Leukemia KW - Dose-response effects KW - Sampling KW - Occupational exposure KW - Lung cancer KW - Mortality KW - USA, Pennsylvania, Philadelphia KW - Careers KW - Cancer KW - Health risks KW - Prostate cancer KW - Firefighter services KW - INE, USA, California, San Francisco KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808617203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Exposure-response+relationships+for+select+cancer+and+non-cancer+health+outcomes+in+a+cohort+of+US+firefighters+from+San+Francisco%2C+Chicago+and+Philadelphia+%281950-2009%29&rft.au=Daniels%2C+Robert+D%3BBertke%2C+Stephen%3BDahm%2C+Matthew+M%3BYiin%2C+James+H%3BKubale%2C+Travis+L%3BHales%2C+Thomas+R%3BBaris%2C+Dalsu%3BZahm%2C+Shelia+H%3BBeaumont%2C+James+J%3BWaters%2C+Kathleen+M%3BPinkerton%2C+Lynne+E&rft.aulast=Daniels&rft.aufirst=Robert&rft.date=2015-10-11&rft.volume=72&rft.issue=10&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102671 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Leukemia; Mortality; Age; Prostate cancer; Injuries; Dose-response effects; Sampling; Occupational exposure; Lung cancer; Models; Health risks; Firefighter services; Careers; Cancer; USA, Illinois, Chicago; USA, Pennsylvania, Philadelphia; INE, USA, California, San Francisco DO - http://dx.doi.org/10.1136/oemed-2014-102671 ER - TY - JOUR T1 - Histopathological and electrophysiological indices of rotenone-evoked dopaminergic toxicity: Neuroprotective effects of acetyl-L-carnitine. AN - 1721351482; 26321151 AB - Exposure to the natural pesticide, rotenone, a potent mitochondrial toxin, leads to degeneration in striatal nerve terminals and nigral neurons. Rotenone-induced behavioral, neurochemical and neuropathological changes in rats mimic those observed in Parkinson's disease (PD). Here, protective effects of acetyl-L-carnitine (ALC) in the brain dopaminergic toxicity after a prolonged exposure to rotenone were evaluated using electrophysiological and immunolabeling methods. Adult, male Sprague-Dawley rats were injected i.p. with rotenone alone (1 mg/kg) or rotenone with ALC (either 10 or 100 mg/kg; ALC10 or ALC100, respectively) once daily on days 1, 3, 5, 8, 10, 12, 15, 17, 19, 22, 24, 26, 29, 31, 33 and 37. Control rats received either 100mg/kg ALC or vehicle (30% Solutol HS 15 in 0.9% saline) injections. Animals were weighed on injection days and monitored daily. Motor nerve conduction velocity (MCV) was assessed within two days after treatment using compound muscle action potentials (CMAP) detected from the tail muscle through surface receiver electrodes installed around the distal part of the tail. Rats were perfused immediately after testing with 4% paraformaldehyde and immunohistochemical analysis of dopamine transporter (DAT), tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), and microglial CD11b marker was performed in the caudate-putamen (CPu) and the substantia nigra pars compacta (SNc) in order to estimate dopaminergic neuronal and transporter damage. Additionally, effects of ALC on preventing microglial or astrocytic hypertrophy were also evaluated. In rats exposed to rotenone and rotenone/ACL10, a significant increases in both proximal (S1) and distal (S2) motor latency and a decrease in MCV were detected in tail nerves (p<0.05). The conduction parameters in rats co-treated with rotenone/ACL100 were not different from control. It was found that 100 mg/kg ALC prevented loss of TH and a decline of DAT level in the midbrain and also prevented the activation of both microglia and astroglia after rotenone treatment. Data indicate neuroprotective effects of ALC in rotenone-evoked dopaminergic neurotoxicity. Published by Elsevier Ireland Ltd. JF - Neuroscience letters AU - Sarkar, S AU - Gough, B AU - Raymick, J AU - Beaudoin, M A AU - Ali, S F AU - Virmani, A AU - Binienda, Z K AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research/FDA, Jefferson, AR, USA. ; Innovation, Research and Development Nutraceuticals and Carnitines International Division, Sigma-tau BV and Sigma-tau HealthScience BV, Groenewoudsedijk 55, Postbus 2079, 3500 GB Utrecht, The Netherlands. ; Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. Electronic address: zbigniew.binienda@fda.hhs.gov. Y1 - 2015/10/08/ PY - 2015 DA - 2015 Oct 08 SP - 53 EP - 59 VL - 606 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Glial Fibrillary Acidic Protein KW - Neuroprotective Agents KW - Pesticides KW - Rotenone KW - 03L9OT429T KW - Acetylcarnitine KW - 6DH1W9VH8Q KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Tyrosine hydroxylase KW - Midbrain KW - Peripheral nerves KW - Dopamine transporter (DAT) KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Tail -- innervation KW - Caudate Nucleus -- metabolism KW - Muscle, Skeletal -- innervation KW - Glial Fibrillary Acidic Protein -- metabolism KW - Action Potentials KW - Muscle, Skeletal -- drug effects KW - Substantia Nigra -- metabolism KW - Rats, Sprague-Dawley KW - Tail -- drug effects KW - Neural Conduction KW - Putamen -- metabolism KW - Dopamine Plasma Membrane Transport Proteins -- metabolism KW - Male KW - Microglia -- metabolism KW - Rotenone -- toxicity KW - Dopamine -- metabolism KW - Acetylcarnitine -- pharmacology KW - Pesticides -- toxicity KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1721351482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Histopathological+and+electrophysiological+indices+of+rotenone-evoked+dopaminergic+toxicity%3A+Neuroprotective+effects+of+acetyl-L-carnitine.&rft.au=Sarkar%2C+S%3BGough%2C+B%3BRaymick%2C+J%3BBeaudoin%2C+M+A%3BAli%2C+S+F%3BVirmani%2C+A%3BBinienda%2C+Z+K&rft.aulast=Sarkar&rft.aufirst=S&rft.date=2015-10-08&rft.volume=606&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=1872-7972&rft_id=info:doi/10.1016%2Fj.neulet.2015.08.044 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-01 N1 - Date created - 2015-10-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neulet.2015.08.044 ER - TY - JOUR T1 - Measurement of impulse peak insertion loss from two acoustic test fixtures and four hearing protector conditions with an acoustic shock tube AN - 1790940494; PQ0003070589 AB - Impulse peak insertion loss (IPIL) was studied with two acoustic test fixtures and four hearing protector conditions at the E-A-RCAL Laboratory. IPIL is the difference between the maximum estimated pressure for the open-ear condition and the maximum pressure measured when a hearing protector is placed on an acoustic test fixture (ATF). Two models of an ATF manufactured by the French-German Research Institute of Saint-Louis (ISL) were evaluated with high-level acoustic impulses created by an acoustic shock tube at levels of 134 decibels (dB), 150 dB, and 168 dB. The fixtures were identical except that the E-A-RCAL ISL fixture had ear canals that were 3 mm longer than the National Institute for Occupational Safety and Health (NIOSH) ISL fixture. Four hearing protection conditions were tested: Combat Arms earplug with the valve open, ETY(R) Plugs earplug, TacticalPro headset, and a dual-protector ETYPlugs earplug with TacticalPro earmuff. The IPILs measured for the E-A-RCAL fixture were 1.4 dB greater than the National Institute for Occupational Safety and Health (NIOSH) ISL ATF. For the E-A-RCAL ISL ATF, the left ear IPIL was 2.0 dB greater than the right ear IPIL. For the NIOSH ATF, the right ear IPIL was 0.3 dB greater than the left ear IPIL. JF - Noise and Health AU - Murphy, William J AU - Fackler, Cameron J AU - Berger, Elliott H AU - Shaw, Peter B AU - Stergar, Mike AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 364 EP - 373 PB - University College London, 330 Gray's Inn Road London WC1X 8EE United Kingdom VL - 17 IS - 78 SN - 1463-1741, 1463-1741 KW - Health & Safety Science Abstracts KW - Acoustics KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790940494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+and+Health&rft.atitle=Measurement+of+impulse+peak+insertion+loss+from+two+acoustic+test+fixtures+and+four+hearing+protector+conditions+with+an+acoustic+shock+tube&rft.au=Murphy%2C+William+J%3BFackler%2C+Cameron+J%3BBerger%2C+Elliott+H%3BShaw%2C+Peter+B%3BStergar%2C+Mike&rft.aulast=Murphy&rft.aufirst=William&rft.date=2015-10-01&rft.volume=17&rft.issue=78&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=Noise+and+Health&rft.issn=14631741&rft_id=info:doi/10.4103%2F1463-1741.165067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Acoustics; Occupational safety DO - http://dx.doi.org/10.4103/1463-1741.165067 ER - TY - JOUR T1 - Cigarette Smoking Prevalence Among Adults Working in the Health Care and Social Assistance Sector, 2008 to 2012 AN - 1762353836; PQ0002503698 AB - Objective: The primary objective of this study was to estimate current smoking among workers in the health care and social assistance sector. Methods: We analyzed the 2008 to 2012 National Health Interview Survey data for adults (age 18 years or more) working in health care and social assistance sector who reported current cigarette smoking. Results: Of the approximately 18.9 million health care and social assistance workers, 16.0% were current cigarette smokers. Smoking prevalence was highest in women (16.9%) and among workers: age 25 to 44 years (17.7%); with a high school education or less (24.4%); with income less than $35,000 (19.5%); with no health insurance (28.5%); in the nursing and residential care facilities (26.9%) industry; and in the material recording, scheduling, dispatching, and distributing (34.7%) occupations. Conclusions: These findings suggest that specific group of workers in the health care and social assistance sector might particularly benefit from cessation programs and incentives to quit smoking. JF - Journal of Occupational and Environmental Medicine AU - Syamlal, Girija AU - Mazurek, Jacek M AU - Storey, Eileen AU - Dube, Shanta R AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, gsyamlal@cdc.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1107 EP - 1112 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 10 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Age KW - Education KW - Health care KW - Cigarettes KW - Cigarette smoking KW - Incentives KW - Insurance KW - Recording KW - Income KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762353836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Cigarette+Smoking+Prevalence+Among+Adults+Working+in+the+Health+Care+and+Social+Assistance+Sector%2C+2008+to+2012&rft.au=Syamlal%2C+Girija%3BMazurek%2C+Jacek+M%3BStorey%2C+Eileen%3BDube%2C+Shanta+R&rft.aulast=Syamlal&rft.aufirst=Girija&rft.date=2015-10-01&rft.volume=57&rft.issue=10&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000529 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Education; Age; Cigarettes; Health care; Cigarette smoking; Incentives; Insurance; Income; Recording DO - http://dx.doi.org/10.1097/JOM.0000000000000529 ER - TY - JOUR T1 - Analysis of gob gas venthole production performances for strata gas control in longwall mining AN - 1734265421; 2015-109890 AB - Longwall mining of coal seams affects a large area of overburden by deforming it and creating stress-relief fractures, as well as bedding plane separations, as the mining face progresses. Stress-relief fractures and bedding plane separations are recognized as major pathways for gas migration from gas-bearing strata into sealed and active areas of the mines. In order for strata gas not to enter and inundate the ventilation system of a mine, gob gas ventholes (GGVs) can be used as a methane control measure. The aim of this paper is to analyze production performances of GGVs drilled over a longwall panel. These boreholes were drilled to control methane emissions from the Pratt group of coals due to stress-relief fracturing and bedding plane separations into a longwall mine operating in the Mary Lee/Blue Creek coal seam of the Upper Pottsville Formation in the Black Warrior Basin, Alabama. During the course of the study, Pratt coal's reservoir properties were integrated with production data of the GGVs. These data were analyzed by using material balance techniques to estimate radius of influence of GGVs, gas-in-place and coal pressures, as well as their variations during mining. The results show that the GGVs drilled to extract gas from the stress-relief zone of the Pratt coal interval is highly effective in removing gas from the Upper Pottsville Formation. The radii of influence of the GGVs were in the order of 330-380 m, exceeding the widths of the panels, due to bedding plane separations and stress relieved by fracturing. Material balance analyses indicated that the initial pressure of the Pratt coals, which was around 648 KPa when longwall mining started, decreased to approximately 150 KPa as the result of strata fracturing and production of released gas. Approximately 70% of the initial gas-in-place within the area of influence of the GGVs was captured during a period of one year. Abstract Copyright (2015) Elsevier, B.V. JF - International Journal of Rock Mechanics and Mining Sciences (1997) AU - Karacan, C Ozgen Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 9 EP - 18 PB - Elsevier, Oxford-New York VL - 79 SN - 1365-1609, 1365-1609 KW - United States KW - mining KW - geologic hazards KW - underground mining KW - Pennsylvanian KW - aliphatic hydrocarbons KW - coal seams KW - Alabama KW - fractures KW - rock bursts KW - faults KW - methane KW - Paleozoic KW - stress KW - Carboniferous KW - alkanes KW - preventive measures KW - Black Warrior Basin KW - organic compounds KW - Mary Lee Mine KW - safety KW - longwall mining KW - natural hazards KW - hydrocarbons KW - Pottsville Group KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734265421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.atitle=Analysis+of+gob+gas+venthole+production+performances+for+strata+gas+control+in+longwall+mining&rft.au=Karacan%2C+C+Ozgen&rft.aulast=Karacan&rft.aufirst=C&rft.date=2015-10-01&rft.volume=79&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Rock+Mechanics+and+Mining+Sciences+%281997%29&rft.issn=13651609&rft_id=info:doi/10.1016%2Fj.ijrmms.2015.08.001 L2 - http://www.sciencedirect.com/science/journal/13651609 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2015, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2015-01-01 N1 - Number of references - 34 N1 - Document feature - illus. incl. 4 tables N1 - Last updated - 2015-11-19 N1 - CODEN - IJRMA2 N1 - SubjectsTermNotLitGenreText - Alabama; aliphatic hydrocarbons; alkanes; Black Warrior Basin; Carboniferous; coal seams; faults; fractures; geologic hazards; hydrocarbons; longwall mining; Mary Lee Mine; methane; mining; natural hazards; organic compounds; Paleozoic; Pennsylvanian; Pottsville Group; preventive measures; rock bursts; safety; stress; underground mining; United States DO - http://dx.doi.org/10.1016/j.ijrmms.2015.08.001 ER - TY - RPRT T1 - FOREWORD AN - 1732067520 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732067520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-10-01&rft.volume=&rft.issue=583&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2015 N1 - Last updated - 2015-11-10 ER - TY - RPRT T1 - Table of contents AN - 1732067519 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732067519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-10-01&rft.volume=&rft.issue=583&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2015 N1 - Last updated - 2015-11-10 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF BROMODICHLOROACETIC ACID (CAS NO. 71133-14-7) IN F344/N RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF BROMODICHLOROACETIC ACID IN F344/NTac RATS AND B6C3F1/N MICE (DRINKING WATER STUDIES) AN - 1732067458 AB - Bromodichloroacetic acid occurs as a by-product of water disinfection. We studied the effects of bromodichloroacetic acid in drinking water on male and female rats and mice to identity potential toxic or cancer-related hazards. We gave drinking water containing 250, 500 or 1,000 mg of bromodichloroacetic acid per liter of water to groups of 50 male and female rats and mice for two years. Control animals received the same tap water with no chemical added. At the end of the study tissues from more than 40 sites were examined for every animal. Groups of female rats and male mice receiving 500 or 1,000 mg/L of bromodichloroacetic acid had lower survival rates than the control groups. Male rats receiving bromodichloroacetic acid had increased rates of malignant mesotheliomas and a variety of skin tumors. Exposed female rats had increased incidences of fibroadenomas and carcinomas of the mammary gland. There were a few occurrences of uncommon tumors of the oral cavity, large intestine, and mammary gland in male rats exposed to bromodichloroacetic acid and of uncommon brain tumors in exposed male and female rats. Incidences of malignant liver tumors (hepatocellular carcinomas and hepatoblastomas) were seen in male and female mice exposed to bromodichloroacetic acid. Exposed male mice had increased incidences of adenomas and carcinomas of the Harderian gland. We conclude that bromodichloroacetic acid in the drinking water caused malignant mesothelioma and skin tumors in male rats and fibroadenomas and carcinomas of the mammary gland in female rats. Brain tumors in male and female rats and tumors of the oral cavity, large intestine, and mammary gland in male rats may also have been related to bromodichloroacetic acid exposure. We conclude that bromodichloroacetic acid caused liver cancer in male and female mice and Harderian gland cancer in male mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 1 EP - 131,133-161,163-177,179-181,183-189,191-193,195-209,211-215,217-231,233-258 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Toxicology KW - Rodents KW - Acids KW - Drinking water KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732067458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+BROMODICHLOROACETIC+ACID+%28CAS+NO.+71133-14-7%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+BROMODICHLOROACETIC+ACID+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-10-01&rft.volume=&rft.issue=583&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Oct 2015 N1 - Document feature - Tables; Graphs; Photographs; References N1 - Last updated - 2015-11-10 ER - TY - JOUR T1 - Ultrafine and respirable particle exposure during vehicle fire suppression AN - 1727690752; PQ0002120240 AB - Vehicle fires are a common occurrence, yet few studies have reported exposures associated with burning vehicles. This article presents an assessment of firefighters' potential for ultrafine and respirable particle exposure during vehicle fire suppression training. Fires were initiated within the engine compartment and passenger cabins of three salvaged vehicles, with subsequent water suppression by fire crews. Firefighter exposures were monitored with an array of direct reading particle and air quality instruments. A flexible metallic duct and blower drew contaminants to the instrument array, positioned at a safe distance from the burning vehicles, with the duct inlet positioned at the nozzle operator's shoulder. The instruments measured the particle number, active surface area, respirable particle mass, photoelectric response, aerodynamic particle size distributions, and air quality parameters. Although vehicle fires were suppressed quickly (<10 minutes), firefighters may be exposed to short duration, high particle concentration episodes during fire suppression, which are orders of magnitude greater than the ambient background concentration. A maximum transient particle concentration of 1.21 10 super(7) particles per cm super(3), 170 mg m super(-3) respirable particle mass, 4700 mu m super(2) cm super(-3) active surface area and 1400 (arbitrary units) in photoelectric response were attained throughout the series of six fires. Expressed as fifteen minute time-weighted averages, engine compartment fires averaged 5.4 10 super(4) particles per cm super(3), 0.36 mg m super(-3) respirable particle mass, 92 mu m super(2) cm super(-3) active particle surface area and 29 (arbitrary units) in photoelectric response. Similarly, passenger cabin fires averaged 2.04 10 super(5) particles per cm super(3), 2.7 mg m super(-3) respirable particle mass, 320 mu m super(2) cm super(-3) active particle surface area, and 34 (arbitrary units) in photoelectric response. Passenger cabin fires were a greater potential source of exposure than engine compartment fires. The wind direction and the relative position of the fire crew to the stationary burning vehicle played a primary role in fire crews' potential for exposure. We recommend that firefighters wear self-contained breathing apparatus during all phases of the vehicle fire response to significantly reduce their potential for particulate, vapor, and gaseous exposures. JF - Environmental Sciences: Processes and Impacts AU - Evans, Douglas E AU - Fent, Kenneth W AD - Chemical Exposure and Monitoring Branch; Division of Applied Research and Technology; National Institute for Occupational Safety and Health; Centers for Disease Control and Prevention; 1090 Tusculum Avenue, MS R-7; Cincinnati; Ohio; USA; +1 513 841 4545; +1 513 841 4407; , dje3@cdc.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1749 EP - 1759 PB - The Royal Society of Chemistry, Burlington House London W1J 0BA United Kingdom VL - 17 IS - 10 SN - 2050-7887, 2050-7887 KW - Environment Abstracts; Pollution Abstracts KW - Particle size KW - Fires KW - Training KW - Surface area KW - Air quality KW - Particulates KW - Vapors KW - Aerodynamics KW - Firefighter services KW - Burning KW - Wind KW - Wear KW - P 0000:AIR POLLUTION KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727690752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Sciences%3A+Processes+and+Impacts&rft.atitle=Ultrafine+and+respirable+particle+exposure+during+vehicle+fire+suppression&rft.au=Evans%2C+Douglas+E%3BFent%2C+Kenneth+W&rft.aulast=Evans&rft.aufirst=Douglas&rft.date=2015-10-01&rft.volume=17&rft.issue=10&rft.spage=1749&rft.isbn=&rft.btitle=&rft.title=Environmental+Sciences%3A+Processes+and+Impacts&rft.issn=20507887&rft_id=info:doi/10.1039%2Fc5em00233h LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 44 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Particle size; Fires; Vapors; Training; Aerodynamics; Surface area; Firefighter services; Air quality; Burning; Particulates; Wear; Wind DO - http://dx.doi.org/10.1039/c5em00233h ER - TY - JOUR T1 - WGS accurately predicts antimicrobial resistance in Escherichia coli AN - 1727679884; PQ0002143030 AB - Objectives The objective of this study was to determine the effectiveness of WGS in identifying resistance genotypes of MDR Escherichia coli and whether these correlate with observed phenotypes. Methods Seventy-six E. coli strains were isolated from farm cattle and measured for phenotypic resistance to 15 antimicrobials with the Sensititre super( registered ) system. Isolates with resistance to at least four antimicrobials in three classes were selected for WGS using an Illumina MiSeq. Genotypic analysis was conducted with in-house Perl scripts using BLAST analysis to identify known genes and mutations associated with clinical resistance. Results Over 30 resistance genes and a number of resistance mutations were identified among the E. coli isolates. Resistance genotypes correlated with 97.8% specificity and 99.6% sensitivity to the identified phenotypes. The majority of discordant results were attributable to the aminoglycoside streptomycin, whereas there was a perfect genotype-phenotype correlation for most antibiotic classes such as tetracyclines, quinolones and phenicols. WGS also revealed information about rare resistance mechanisms, such as structural mutations in chromosomal copies of ampC conferring third-generation cephalosporin resistance. Conclusions WGS can provide comprehensive resistance genotypes and is capable of accurately predicting resistance phenotypes, making it a valuable tool for surveillance. Moreover, the data presented here showing the ability to accurately predict resistance suggest that WGS may be used as a screening tool in selecting anti-infective therapy, especially as costs drop and methods improve. JF - Journal of Antimicrobial Chemotherapy AU - Tyson, Gregory H AU - McDermott, Patrick F AU - Li, Cong AU - Chen, Yuansha AU - Tadesse, Daniel A AU - Mukherjee, Sampa AU - Bodeis-Jones, Sonya AU - Kabera, Claudine AU - Gaines, Stuart A AU - Loneragan, Guy H AU - Edrington, Tom S AU - Torrence, Mary AU - Harhay, Dayna M AU - Zhao, Shaohua Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 2763 EP - 2769 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 70 IS - 10 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cephalosporins KW - Data processing KW - Farms KW - Drug resistance KW - Quinolones KW - Antibiotics KW - Genotypes KW - Streptomycin KW - Tetracyclines KW - Aminoglycoside antibiotics KW - Antimicrobial agents KW - Escherichia coli KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727679884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=WGS+accurately+predicts+antimicrobial+resistance+in+Escherichia+coli&rft.au=Tyson%2C+Gregory+H%3BMcDermott%2C+Patrick+F%3BLi%2C+Cong%3BChen%2C+Yuansha%3BTadesse%2C+Daniel+A%3BMukherjee%2C+Sampa%3BBodeis-Jones%2C+Sonya%3BKabera%2C+Claudine%3BGaines%2C+Stuart+A%3BLoneragan%2C+Guy+H%3BEdrington%2C+Tom+S%3BTorrence%2C+Mary%3BHarhay%2C+Dayna+M%3BZhao%2C+Shaohua&rft.aulast=Tyson&rft.aufirst=Gregory&rft.date=2015-10-01&rft.volume=70&rft.issue=10&rft.spage=2763&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkv186 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Cephalosporins; Farms; Data processing; Drug resistance; Quinolones; Antibiotics; Streptomycin; Genotypes; Tetracyclines; Mutation; Aminoglycoside antibiotics; Antimicrobial agents; Escherichia coli DO - http://dx.doi.org/10.1093/jac/dkv186 ER - TY - JOUR T1 - Direct-acting antiviral drug approvals for treatment of chronic hepatitis C virus infection: Scientific and regulatory approaches to clinical trial designs AN - 1722178463; PQ0002089829 AB - Therapeutic options for treatment of chronic hepatitis C have improved substantially since the approval of direct-acting antiviral agents (DAAs). Several interferon (IFN)-free or IFN- and ribavirin (RBV)-free treatment regimens with shorter durations and improved efficacy and safety profiles are now available. The U.S. Food and Drug Administration (FDA) used several scientific approaches and regulatory mechanisms, such as (1) use of a "validated" surrogate (sustained virological response) for a primary endpoint, (2) shortening the time point for measuring the surrogate by 12 weeks, (3) use of historical controls when clinically appropriate, and (4) use of modeling when scientifically sound to extend treatment indications to subpopulations not fully evaluated in clinical trials, which had an impact on DAA development and subsequent approvals. This article intends to provide increased transparency about the FDA's scientific approaches and regulatory processes that supported drug development and marketing approval of DAAs for treatment of hepatitis C, a serious, life-threatening infection. (Hepatology 2015; 62:1298-1303) JF - Hepatology AU - Mishra, Poonam AU - Murray, Jeffrey AU - Birnkrant, Debra AD - Division of Antiviral Products/Office of Antimicrobial Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 1298 EP - 1303 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 62 IS - 4 SN - 0270-9139, 0270-9139 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - Interferon KW - Hepatitis C virus KW - Antiviral agents KW - Subpopulations KW - Ribavirin KW - Chronic infection KW - Drug development KW - Hepatitis C KW - Clinical trials KW - A 01330:Food Microbiology KW - F 06910:Microorganisms & Parasites KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722178463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Pharmacokinetics+of+bisphenol+A+in+humans+following+a+single+oral+administration.&rft.au=Thayer%2C+Kristina+A%3BDoerge%2C+Daniel+R%3BHunt%2C+Dawn%3BSchurman%2C+Shepherd+H%3BTwaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BGarantziotis%2C+Stavros%3BKissling%2C+Grace+E%3BEasterling%2C+Michael+R%3BBucher%2C+John+R%3BBirnbaum%2C+Linda+S&rft.aulast=Thayer&rft.aufirst=Kristina&rft.date=2015-10-01&rft.volume=83&rft.issue=&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2015.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Interferon; Antiviral agents; Subpopulations; Chronic infection; Ribavirin; Drug development; Hepatitis C; Clinical trials; Hepatitis C virus DO - http://dx.doi.org/10.1002/hep.27880 ER - TY - JOUR T1 - Estrogen Selectively Mobilizes Neural Stem Cells in the Third Ventricle Stem Cell Niche of Postnatal Day 21 Rats AN - 1722178163; PQ0002072611 AB - The neuroprotective properties of stem cells have been described for various pathophysiological states. Here, we determined the effects of exogenous perinatal estrogen treatment on endogenous neural stem cell activity in the third ventricle stem cell niche (3VSCN) and the caudal third ventricle (C3V). Pregnant Sprague-Dawley rats were gavaged with ethinyl estradiol (EE sub(2), 10 mu g/kg/day) or vehicle on gestational days 6-21, and their offspring were similarly treated from birth to weaning on postnatal day 21. At weaning, neural stem cell activity was investigated using the stem cell markers nestin, Ki-67, phosphohistone H3 (PHH3), and doublecortin (DCX). The 3VSCN was characterized by nestin labeling, but little DCX labeling, while both the subventricular (SVZ) and subgranular zones (SGZ) displayed robust DCX expression. Ki-67 cell counts in the 3VSCN were 2.2 to 6.4 times those of the C3V. In the 3VSCN, EE sub(2) treatment significantly increased Ki-67, PHH3, and co-labeled cell counts by 135-207 %, effects which appeared stronger in females. EE sub(2) treatment had only marginally significant effects in the C3V, mildly increasing PHH3 and co-labeled cell counts. Perinatal estrogen treatment selectively increased and mobilized proliferative cells in the 3VSCN at weaning, potentially providing increased neuroprotection. Because PHH3 cells are thought to be in the mitotic phase of the cell cycle and Ki-67 cells can be found in most phases of the cycle, the effect of estrogen treatment on 3VSCN cells appears to involve enhancement of mitosis. JF - Molecular Neurobiology AU - He, Zhen AU - Cui, Li AU - Paule, Merle G AU - Ferguson, Sherry A AD - HFT-132, Division of Neurotoxicology, National Center for Toxicological Research/FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA, Sherry.Ferguson@fda.hhs.gov Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 927 EP - 933 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 52 IS - 2 SN - 0893-7648, 0893-7648 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Ventricles (cerebral) KW - Estrogens KW - Cell cycle KW - Weaning KW - Neuroprotection KW - Pregnancy KW - Nervous system KW - Stem cells KW - Ethinyl estradiol KW - Mitosis KW - Nestin KW - Progeny KW - Doublecortin protein KW - Neural stem cells KW - N3 11007:Neurobiology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722178163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Neurobiology&rft.atitle=Estrogen+Selectively+Mobilizes+Neural+Stem+Cells+in+the+Third+Ventricle+Stem+Cell+Niche+of+Postnatal+Day+21+Rats&rft.au=He%2C+Zhen%3BCui%2C+Li%3BPaule%2C+Merle+G%3BFerguson%2C+Sherry+A&rft.aulast=He&rft.aufirst=Zhen&rft.date=2015-10-01&rft.volume=52&rft.issue=2&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Molecular+Neurobiology&rft.issn=08937648&rft_id=info:doi/10.1007%2Fs12035-015-9244-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 43 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Estrogens; Ventricles (cerebral); Cell cycle; Weaning; Neuroprotection; Pregnancy; Stem cells; Nervous system; Ethinyl estradiol; Mitosis; Nestin; Progeny; Doublecortin protein; Neural stem cells DO - http://dx.doi.org/10.1007/s12035-015-9244-9 ER - TY - JOUR T1 - MiRNA-Mediated Regulation of the SWI/SNF Chromatin Remodeling Complex Controls Pluripotency and Endodermal Differentiation in Human ESCs AN - 1722177713; PQ0002019745 AB - MicroRNAs and chromatin remodeling complexes represent powerful epigenetic mechanisms that regulate the pluripotent state. miR-302 is a strong inducer of pluripotency, which is characterized by a distinct chromatin architecture. This suggests that miR-302 regulates global chromatin structure; however, a direct relationship between miR-302 and chromatin remodelers has not been established. Here, we provide data to show that miR-302 regulates Brg1 chromatin remodeling complex composition in human embryonic stem cells (hESCs) through direct repression of the BAF53a and BAF170 subunits. With the subsequent overexpression of BAF170 in hESCs, we show that miR-302's inhibition of BAF170 protein levels can affect the expression of genes involved in cell proliferation. Furthermore, miR-302-mediated repression of BAF170 regulates pluripotency by positively influencing mesendodermal differentiation. Overexpression of BAF170 in hESCs led to biased differentiation toward the ectoderm lineage during EB formation and severely hindered directed definitive endoderm differentiation. Taken together, these data uncover a direct regulatory relationship between miR-302 and the Brg1 chromatin remodeling complex that controls gene expression and cell fate decisions in hESCs and suggests that similar mechanisms are at play during early human development. Stem Cells 2015; 33:2925-2935 JF - Stem Cells AU - Wade, Staton L AU - Langer, Lee F AU - Ward, James M AU - Archer, Trevor K AD - Chromatin and Gene Expression Group, Epigenetics and Stem Cell Biology Laboratory, Department of Health and Human Services. Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 2925 EP - 2935 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 33 IS - 10 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Play KW - Data processing KW - Chromatin remodeling KW - Ectoderm KW - miRNA KW - Differentiation KW - Stem cells KW - Embryo cells KW - epigenetics KW - Endoderm KW - Cell fate KW - Cell proliferation KW - BRG1 protein KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722177713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=MiRNA-Mediated+Regulation+of+the+SWI%2FSNF+Chromatin+Remodeling+Complex+Controls+Pluripotency+and+Endodermal+Differentiation+in+Human+ESCs&rft.au=Wade%2C+Staton+L%3BLanger%2C+Lee+F%3BWard%2C+James+M%3BArcher%2C+Trevor+K&rft.aulast=Wade&rft.aufirst=Staton&rft.date=2015-10-01&rft.volume=33&rft.issue=10&rft.spage=2925&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/10.1002%2Fstem.2084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Data processing; Play; Chromatin remodeling; Ectoderm; miRNA; Differentiation; Stem cells; Embryo cells; epigenetics; Endoderm; Cell fate; Cell proliferation; BRG1 protein DO - http://dx.doi.org/10.1002/stem.2084 ER - TY - JOUR T1 - FDA Approval Summary: Olaparib Monotherapy in Patients with Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer Treated with Three or More Lines of Chemotherapy. AN - 1718908262; 26187614 AB - On December 19, 2014, the FDA approved olaparib capsules (Lynparza; AstraZeneca) for the treatment of patients with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm) advanced ovarian cancer who have been treated with three or more prior lines of chemotherapy. The BRACAnalysis CDx (Myriad Genetic Laboratories, Inc.) was approved concurrently. An international multicenter, single-arm trial enrolled 137 patients with measurable gBRCAm-associated ovarian cancer treated with three or more prior lines of chemotherapy. Patients received olaparib at a dose of 400 mg by mouth twice daily until disease progression or unacceptable toxicity. The objective response rate (ORR) was 34% with median response duration of 7.9 months in this cohort. The most common adverse reactions (≥20%) in patients treated with olaparib were anemia, nausea, fatigue (including asthenia), vomiting, diarrhea, dysgeusia, dyspepsia, headache, decreased appetite, nasopharyngitis/pharyngitis/upper respiratory infection, cough, arthralgia/musculoskeletal pain, myalgia, back pain, dermatitis/rash, and abdominal pain/discomfort. Myelodysplatic syndrome and/or acute myeloid leukemia occurred in 2% of the patients enrolled on this trial. ©2015 American Association for Cancer Research. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kim, Geoffrey AU - Ison, Gwynn AU - McKee, Amy E AU - Zhang, Hui AU - Tang, Shenghui AU - Gwise, Thomas AU - Sridhara, Rajeshwari AU - Lee, Eunice AU - Tzou, Abraham AU - Philip, Reena AU - Chiu, Haw-Jyh AU - Ricks, Tiffany K AU - Palmby, Todd AU - Russell, Anne Marie AU - Ladouceur, Gaetan AU - Pfuma, Elimika AU - Li, Hongshan AU - Zhao, Liang AU - Liu, Qi AU - Venugopal, Rajesh AU - Ibrahim, Amna AU - Pazdur, Richard AD - Office of Hematology and Oncology Products (OHOP), U.S. Food and Drug Administration, Silver Spring, Maryland. Geoffrey.Kim@fda.hhs.gov. ; Office of Hematology and Oncology Products (OHOP), U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Biostatistics, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of In Vitro Diagnostics and Radiological Health, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Maryland. ; New Drug Quality Assessment, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Clinical Pharmacology, U.S. Food and Drug Administration, Silver Spring, Maryland. Y1 - 2015/10/01/ PY - 2015 DA - 2015 Oct 01 SP - 4257 EP - 4261 VL - 21 IS - 19 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Phthalazines KW - Piperazines KW - Poly(ADP-ribose) Polymerase Inhibitors KW - olaparib KW - WOH1JD9AR8 KW - Index Medicus KW - United States KW - Animals KW - Poly(ADP-ribose) Polymerase Inhibitors -- therapeutic use KW - Neoplasm Staging KW - Poly(ADP-ribose) Polymerase Inhibitors -- pharmacology KW - Humans KW - Treatment Outcome KW - Clinical Trials as Topic KW - Drug Evaluation, Preclinical KW - Female KW - Ovarian Neoplasms -- genetics KW - Piperazines -- therapeutic use KW - Genes, BRCA2 KW - Phthalazines -- therapeutic use KW - Genes, BRCA1 KW - Piperazines -- pharmacology KW - Ovarian Neoplasms -- drug therapy KW - United States Food and Drug Administration KW - Drug Approval KW - Ovarian Neoplasms -- pathology KW - Germ-Line Mutation KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Phthalazines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718908262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=FDA+Approval+Summary%3A+Olaparib+Monotherapy+in+Patients+with+Deleterious+Germline+BRCA-Mutated+Advanced+Ovarian+Cancer+Treated+with+Three+or+More+Lines+of+Chemotherapy.&rft.au=Kim%2C+Geoffrey%3BIson%2C+Gwynn%3BMcKee%2C+Amy+E%3BZhang%2C+Hui%3BTang%2C+Shenghui%3BGwise%2C+Thomas%3BSridhara%2C+Rajeshwari%3BLee%2C+Eunice%3BTzou%2C+Abraham%3BPhilip%2C+Reena%3BChiu%2C+Haw-Jyh%3BRicks%2C+Tiffany+K%3BPalmby%2C+Todd%3BRussell%2C+Anne+Marie%3BLadouceur%2C+Gaetan%3BPfuma%2C+Elimika%3BLi%2C+Hongshan%3BZhao%2C+Liang%3BLiu%2C+Qi%3BVenugopal%2C+Rajesh%3BIbrahim%2C+Amna%3BPazdur%2C+Richard&rft.aulast=Kim&rft.aufirst=Geoffrey&rft.date=2015-10-01&rft.volume=21&rft.issue=19&rft.spage=4257&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-0887 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-11 N1 - Date created - 2015-10-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-0887 ER - TY - JOUR T1 - Scientific and Regulatory Policy Committee Review: Review of the Organisation for Economic Co-operation and Development (OECD) Guidance on the GLP Requirements for Peer Review of Histopathology. AN - 1718906893; 26208968 AB - In 2014, the Organisation for Economic Co-operation and Development (OECD) issued guidance no. 16, Guidance on the GLP Requirements for Peer Review of Histopathology. The stated purpose of the guidance document is "to provide guidance to pathologists, test facility management, study directors and quality assurance personnel on how the peer review of histopathology should be planned, managed, documented, and reported in order to meet Good Laboratory Practice (GLP) expectations and requirements." On behalf of and in collaboration with the global societies of toxicologic pathology, the Society of Toxicologic Pathology initiated a review of OECD guidance no. 16. The objectives of this review are to provide a unified interpretation of the guidance, to recommend compliant processes for organizations to implement, and to avoid inconsistent process adaptations across the industry. This review of the guidance document is the product of a global collaboration with other societies of toxicologic pathology and provides a section-by-section international consensus view and interpretation of the OECD guidance on peer review. © 2015 by The Author(s). JF - Toxicologic pathology AU - Fikes, James D AU - Patrick, Daniel J AU - Francke, Sabine AU - Frazier, Kendall S AU - Reindel, James F AU - Romeike, Annette AU - Spaet, Robert H AU - Tomlinson, Lindsay AU - Schafer, Kenneth A AU - Socity of Toxicologic Pathology AD - Biogen, Cambridge, Massachusetts, USA Both James D. Fikes and Daniel J. Patrick contributed equally to this article. jim.fikes@biogen.com. ; MPI Research, Mattawan, Michigan, USA Both James D. Fikes and Daniel J. Patrick contributed equally to this article. ; US Food and Drug Administration, College Park, Maryland, USA. ; GlaxoSmithKline, King of Prussia, Pennsylvania, USA. ; Amgen Inc., Seattle, Washington, USA. ; Covance Laboratories, Porcheville, France. ; RSPathologics, Granby, Colorado, USA. ; Pfizer Inc., Andover, Massachusetts, USA. ; Vet Path Services, Inc., Mason, Ohio, USA. ; Socity of Toxicologic Pathology Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 907 EP - 914 VL - 43 IS - 7 KW - Index Medicus KW - guidance KW - GLP KW - regulatory KW - peer review KW - pathology KW - OECD KW - histopathology KW - Animals KW - Humans KW - Organisation for Economic Co-Operation and Development KW - Peer Review -- standards KW - Toxicology -- standards KW - Pathology, Clinical -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718906893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Scientific+and+Regulatory+Policy+Committee+Review%3A+Review+of+the+Organisation+for+Economic+Co-operation+and+Development+%28OECD%29+Guidance+on+the+GLP+Requirements+for+Peer+Review+of+Histopathology.&rft.au=Fikes%2C+James+D%3BPatrick%2C+Daniel+J%3BFrancke%2C+Sabine%3BFrazier%2C+Kendall+S%3BReindel%2C+James+F%3BRomeike%2C+Annette%3BSpaet%2C+Robert+H%3BTomlinson%2C+Lindsay%3BSchafer%2C+Kenneth+A%3BSocity+of+Toxicologic+Pathology&rft.aulast=Fikes&rft.aufirst=James&rft.date=2015-10-01&rft.volume=43&rft.issue=7&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623315596382 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-21 N1 - Date created - 2015-10-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623315596382 ER - TY - JOUR T1 - Occupational Exposure to Benzene and Non-Hodgkin Lymphoma in a Population-Based Cohort: The Shanghai Women's Health Study. AN - 1718904299; 25748391 AB - The association between benzene exposure and non-Hodgkin lymphoma (NHL) has been the subject of debate as a result of inconsistent epidemiologic evidence. An International Agency for Research on Cancer (IARC) working group evaluated benzene in 2009 and noted evidence for a positive association between benzene exposure and NHL risk. We evaluated the association between occupational benzene exposure and NHL among 73,087 women enrolled in the prospective population-based Shanghai Women's Health Study. Benzene exposure estimates were derived using a previously developed exposure assessment framework that combined ordinal job-exposure matrix intensity ratings with quantitative benzene exposure measurements from an inspection database of Shanghai factories collected between 1954 and 2000. Associations between benzene exposure metrics and NHL (n = 102 cases) were assessed using Cox proportional hazard models, with study follow-up occurring from December 1996 through December 2009. Women ever exposed to benzene had a significantly higher risk of NHL [hazard ratio (HR) = 1.87, 95% CI: 1.19, 2.96]. Compared with unexposed women, significant trends in NHL risk were observed for increasing years of benzene exposure (p(trend) = 0.006) and increasing cumulative exposure levels (p(trend) = 0.005), with the highest duration and cumulative exposure tertiles having a significantly higher association with NHL (HR = 2.07, 95% CI: 1.07, 4.01 and HR = 2.16, 95% CI: 1.17, 3.98, respectively). Our findings, using a population-based prospective cohort of women with diverse occupational histories, provide additional evidence that occupational exposure to benzene is associated with NHL risk. JF - Environmental health perspectives AU - Bassig, Bryan A AU - Friesen, Melissa C AU - Vermeulen, Roel AU - Shu, Xiao-Ou AU - Purdue, Mark P AU - Stewart, Patricia A AU - Xiang, Yong-Bing AU - Chow, Wong-Ho AU - Zheng, Tongzhang AU - Ji, Bu-Tian AU - Yang, Gong AU - Linet, Martha S AU - Hu, Wei AU - Zhang, Heping AU - Zheng, Wei AU - Gao, Yu-Tang AU - Rothman, Nathaniel AU - Lan, Qing AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 971 EP - 977 VL - 123 IS - 10 KW - Benzene KW - J64922108F KW - Index Medicus KW - Prospective Studies KW - Women's Health KW - Humans KW - China -- epidemiology KW - Adult KW - Aged KW - Middle Aged KW - Female KW - Risk Assessment KW - Occupational Exposure KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Benzene -- analysis KW - Occupational Diseases -- epidemiology KW - Lymphoma, Non-Hodgkin -- chemically induced KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718904299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Occupational+Exposure+to+Benzene+and+Non-Hodgkin+Lymphoma+in+a+Population-Based+Cohort%3A+The+Shanghai+Women%27s+Health+Study.&rft.au=Bassig%2C+Bryan+A%3BFriesen%2C+Melissa+C%3BVermeulen%2C+Roel%3BShu%2C+Xiao-Ou%3BPurdue%2C+Mark+P%3BStewart%2C+Patricia+A%3BXiang%2C+Yong-Bing%3BChow%2C+Wong-Ho%3BZheng%2C+Tongzhang%3BJi%2C+Bu-Tian%3BYang%2C+Gong%3BLinet%2C+Martha+S%3BHu%2C+Wei%3BZhang%2C+Heping%3BZheng%2C+Wei%3BGao%2C+Yu-Tang%3BRothman%2C+Nathaniel%3BLan%2C+Qing&rft.aulast=Bassig&rft.aufirst=Bryan&rft.date=2015-10-01&rft.volume=123&rft.issue=10&rft.spage=971&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408307 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-13 N1 - Date created - 2015-10-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):405-8 [17337643] Occup Environ Med. 2003 Sep;60(9):676-9 [12937190] Environ Mol Mutagen. 2007 Jul;48(6):467-74 [17584886] Environ Mol Mutagen. 2008 Jul;49(6):453-7 [18481315] Am J Ind Med. 2008 Nov;51(11):803-11 [18651579] Epidemiology. 2003 Sep;14(5):569-77 [14501272] Int J Occup Environ Health. 2004 Jan-Mar;10(1):13-21 [15070021] Am J Ind Med. 1996 Mar;29(3):236-46 [8833776] Occup Environ Med. 1996 Nov;53(11):773-81 [9038803] J Natl Cancer Inst. 1997 Jul 16;89(14):1065-71 [9230889] Science. 2004 Dec 3;306(5702):1774-6 [15576619] Am J Epidemiol. 2005 Dec 1;162(11):1123-31 [16236996] Lifetime Data Anal. 2007 Jun;13(2):261-72 [17401682] Blood. 2008 Nov 15;112(10):4247-9 [18711000] Toxicol Ind Health. 2008 Jun-Jul;24(5-6):263-398 [19022880] Blood. 2008 Dec 15;112(13):5150-60 [18796628] Am J Epidemiol. 2009 Jan 15;169(2):176-85 [19056833] Toxicol Sci. 2009 Aug;110(2):293-306 [19478238] J Occup Environ Hyg. 2009 Nov;6(11):659-70 [19753498] Lancet Oncol. 2009 Dec;10(12):1143-4 [19998521] Chem Biol Interact. 2010 Mar 19;184(1-2):129-46 [19900422] Occup Environ Med. 2010 May;67(5):341-7 [20447988] Blood. 2010 Nov 18;116(20):e90-8 [20699439] Environ Health Perspect. 2011 Feb;119(2):159-67 [20880796] Ann Occup Hyg. 2012 Jan;56(1):80-91 [21976309] Cancer Res. 2012 Sep 15;72(18):4733-43 [22846913] J Natl Cancer Inst. 2012 Nov 21;104(22):1724-37 [23111193] Blood. 2013 Aug 8;122(6):951-7 [23814017] Cancer Causes Control. 2001 Apr;12(3):201-12 [11405325] Crit Rev Toxicol. 2002 Jan;32(1):1-42 [11846214] Am J Ind Med. 2002 Oct;42(4):275-85 [12271475] Epidemiology. 2006 Sep;17(5):552-61 [16878041] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408307 ER - TY - JOUR T1 - On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: An update. AN - 1717472890; 26122973 AB - Therapeutic approaches based on isolated compounds obtained from natural products to handle central and peripheral disorders involving oxidative stress and inflammation are more common nowadays. The validation of nutraceutics vs. pharmaceutics as tools to induce preventive and protective profiles in human health alterations is still far of complete acceptance, but the basis to start more solid experimental and clinical protocols with natural products has already begun. S-allyl cysteine (SAC) is a promising garlic-derived organosulfur compound exhibiting a considerable number of positive actions in cell models and living systems. An update, in the form of review, is needed from time to time to get access to the state-of-the-art on this topic. In this review we visited recent and refreshing evidence of new already proven and potential targets to explain the benefits of using SAC against toxic and pathological conditions. The broad spectrum of protective actions covered by this molecule comprises antioxidant, redox modulatory and anti-inflammatory activities, accompanied by anti-apoptotic, pro-energetic and signaling capacities. Herein, we detail the evidence on these aspects to provide the reader a more complete overview on the promising aspects of SAC in research. Published by Elsevier Ltd. JF - Neurochemistry international AU - Colín-González, Ana Laura AU - Ali, Syed F AU - Túnez, Isaac AU - Santamaría, Abel AD - Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, SSA, Mexico City, Mexico. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR, USA. Electronic address: Syed.ali@fda.hhs.gov. ; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofia/Universidad de Córdoba, Cordoba, Spain; Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad (RETICEF), Spain. ; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, SSA, Mexico City, Mexico. Electronic address: absada@yahoo.com. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 83 EP - 91 VL - 89 KW - Advanced Glycosylation End Product-Specific Receptor KW - 0 KW - Anti-Inflammatory Agents KW - Antioxidants KW - Neuroprotective Agents KW - S-allylcysteine KW - 81R3X99M15 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Garlic-derived organosulfur compounds KW - Oxidative stress KW - S-allyl cysteine KW - Neuroprotection KW - Neuroinflammation KW - Animals KW - Oxidation-Reduction -- drug effects KW - Humans KW - Advanced Glycosylation End Product-Specific Receptor -- metabolism KW - Cysteine -- metabolism KW - Cysteine -- analogs & derivatives KW - Neuroprotective Agents -- pharmacology KW - Anti-Inflammatory Agents -- metabolism KW - Cysteine -- pharmacology KW - Neuroprotective Agents -- chemistry KW - Antioxidants -- metabolism KW - Cysteine -- chemistry KW - Anti-Inflammatory Agents -- chemistry KW - Antioxidants -- pharmacology KW - Neuroprotective Agents -- metabolism KW - Antioxidants -- chemistry KW - Garlic KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717472890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=On+the+antioxidant%2C+neuroprotective+and+anti-inflammatory+properties+of+S-allyl+cysteine%3A+An+update.&rft.au=Col%C3%ADn-Gonz%C3%A1lez%2C+Ana+Laura%3BAli%2C+Syed+F%3BT%C3%BAnez%2C+Isaac%3BSantamar%C3%ADa%2C+Abel&rft.aulast=Col%C3%ADn-Gonz%C3%A1lez&rft.aufirst=Ana&rft.date=2015-10-01&rft.volume=89&rft.issue=&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=1872-9754&rft_id=info:doi/10.1016%2Fj.neuint.2015.06.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-04 N1 - Date created - 2015-09-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuint.2015.06.011 ER - TY - JOUR T1 - UVA photoirradiation of benzo[a]pyrene metabolites: induction of cytotoxicity, reactive oxygen species, and lipid peroxidation. AN - 1716937869; 23552265 AB - Benzo[a]pyrene (BaP) is a prototype for studying carcinogenesis of polycyclic aromatic hydrocarbons (PAHs). We have long been interested in studying the phototoxicity of PAHs. In this study, we determined that metabolism of BaP by human skin HaCaT keratinocytes resulted in six identified phase I metabolites, for example, BaP trans-7,8-dihydrodiol (BaP t-7,8-diol), BaP t-4,5-diol, BaP t-9,10-diol, 3-hydroxybenzo[a]pyrene (3-OH-BaP), BaP (7,10/8,9)tetrol, and BaP (7/8,9,10)tetrol. The photocytotoxicity of BaP, 3-OH-BaP, BaP t-7,8-diol, BaP trans-7,8-diol-anti-9,10-epoxide (BPDE), and BaP (7,10/8,9)tetrol in the HaCaT keratinocytes was examined. When irradiated with 1.0 J/cm(2) UVA light, these compounds when tested at doses of 0.1, 0.2, and 0.5 μM, all induced photocytotoxicity in a dose-dependent manner. When photoirradiation was conducted in the presence of a lipid (methyl linoleate), BaP metabolites, BPDE, and three related PAHs, pyrene, 7,8,9,10-tetrahydro-BaP trans-7,8-diol, and 7,8,9,10-tetrahydro-BaP trans-9,10-diol, all induced lipid peroxidation. The formation of lipid peroxides by BaP t-7,8-diol was inhibited by NaN3 and enhanced by deuterated methanol, which suggests that singlet oxygen may be involved in the generation of lipid peroxides. The formation of lipid hydroperoxides was partially inhibited by superoxide dismutase (SOD). Electron spin resonance spin trapping experiments indicated that both singlet oxygen and superoxide radical anion were generated from UVA photoirradiation of BPDE in a light dose responding manner. © The Author(s) 2013. JF - Toxicology and industrial health AU - Xia, Qingsu AU - Chiang, Hsiu-Mei AU - Yin, Jun-Jie AU - Chen, Shoujun AU - Cai, Lining AU - Yu, Hongtao AU - Fu, Peter P AD - National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA Department of Cosmecutics, China Medical University, Taichung, Taiwan, Republic of China. ; Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, USA. ; Biotranex LLC, Monmouth Junction, NJ, USA. ; Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA peter.fu@fda.hhs.gov. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 898 EP - 910 VL - 31 IS - 10 KW - Reactive Oxygen Species KW - 0 KW - Benzo(a)pyrene KW - 3417WMA06D KW - Index Medicus KW - Benzo[a]pyrene KW - Polycyclic aromatic hydrocarbons (PAHs) KW - metabolite KW - reactive oxygen species (ROS) KW - lipid peroxidation KW - Ultraviolet Rays KW - Cells, Cultured KW - Humans KW - Reactive Oxygen Species -- metabolism KW - Cell Survival -- drug effects KW - Keratinocytes -- drug effects KW - Benzo(a)pyrene -- toxicity KW - Lipid Peroxidation -- drug effects KW - Benzo(a)pyrene -- chemistry KW - Benzo(a)pyrene -- radiation effects KW - Benzo(a)pyrene -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1716937869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=UVA+photoirradiation+of+benzo%5Ba%5Dpyrene+metabolites%3A+induction+of+cytotoxicity%2C+reactive+oxygen+species%2C+and+lipid+peroxidation.&rft.au=Xia%2C+Qingsu%3BChiang%2C+Hsiu-Mei%3BYin%2C+Jun-Jie%3BChen%2C+Shoujun%3BCai%2C+Lining%3BYu%2C+Hongtao%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2015-10-01&rft.volume=31&rft.issue=10&rft.spage=898&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=1477-0393&rft_id=info:doi/10.1177%2F0748233713484648 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-14 N1 - Date created - 2015-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1177/0748233713484648 ER - TY - JOUR T1 - Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage. AN - 1716937524; 26206149 AB - Sevoflurane is a volatile anesthetic that has been widely used in general anesthesia, yet its safety in pediatric use is a public concern. This study sought to evaluate whether prolonged exposure of infant monkeys to a clinically relevant concentration of sevoflurane is associated with any adverse effects on the developing brain. Infant monkeys were exposed to 2.5% sevoflurane for 9 h, and frontal cortical tissues were harvested for DNA microarray, lipidomics, Luminex protein, and histological assays. DNA microarray analysis showed that sevoflurane exposure resulted in a broad identification of differentially expressed genes (DEGs) in the monkey brain. In general, these genes were associated with nervous system development, function, and neural cell viability. Notably, a number of DEGs were closely related to lipid metabolism. Lipidomic analysis demonstrated that critical lipid components, (eg, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol) were significantly downregulated by prolonged exposure of sevoflurane. Luminex protein analysis indicated abnormal levels of cytokines in sevoflurane-exposed brains. Consistently, Fluoro-Jade C staining revealed more degenerating neurons after sevoflurane exposure. These data demonstrate that a clinically relevant concentration of sevoflurane (2.5%) is capable of inducing and maintaining an effective surgical plane of anesthesia in the developing nonhuman primate and that a prolonged exposure of 9 h resulted in profound changes in gene expression, cytokine levels, lipid metabolism, and subsequently, neuronal damage. Generally, sevoflurane-induced neuronal damage was also associated with changes in lipid content, composition, or both; and specific lipid changes could provide insights into the molecular mechanism(s) underlying anesthetic-induced neurotoxicity and may be sensitive biomarkers for the early detection of anesthetic-induced neuronal damage. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by a US Government employee and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Liu, Fang AU - Rainosek, Shuo W AU - Frisch-Daiello, Jessica L AU - Patterson, Tucker A AU - Paule, Merle G AU - Slikker, William AU - Wang, Cheng AU - Han, Xianlin AD - *Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079; Fang.liu@fda.hhs.gov. ; Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, AR 72205; ; Diabetes and Obesity Research Center, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando, FL 32827; and. ; *Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079; ; Office of the Director, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 562 EP - 572 VL - 147 IS - 2 KW - Anesthetics, Inhalation KW - 0 KW - Methyl Ethers KW - sevoflurane KW - 38LVP0K73A KW - Index Medicus KW - cytokines KW - development KW - neuronal degeneration KW - lipid metabolism KW - Animals, Newborn KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Brain Chemistry -- drug effects KW - Macaca mulatta KW - Male KW - Female KW - Inhalation Exposure -- adverse effects KW - Methyl Ethers -- adverse effects KW - Anesthetics, Inhalation -- adverse effects KW - Methyl Ethers -- administration & dosage KW - Lipid Metabolism -- drug effects KW - Neurons -- drug effects KW - Brain -- drug effects KW - Brain -- metabolism KW - Anesthetics, Inhalation -- administration & dosage KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1716937524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Potential+Adverse+Effects+of+Prolonged+Sevoflurane+Exposure+on+Developing+Monkey+Brain%3A+From+Abnormal+Lipid+Metabolism+to+Neuronal+Damage.&rft.au=Liu%2C+Fang%3BRainosek%2C+Shuo+W%3BFrisch-Daiello%2C+Jessica+L%3BPatterson%2C+Tucker+A%3BPaule%2C+Merle+G%3BSlikker%2C+William%3BWang%2C+Cheng%3BHan%2C+Xianlin&rft.aulast=Liu&rft.aufirst=Fang&rft.date=2015-10-01&rft.volume=147&rft.issue=2&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv150 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-19 N1 - Date created - 2015-09-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neuroscience. 2000;97(3):591-600 [10828541] Neurosci Biobehav Rev. 2013 Mar;37(3):436-47 [23370232] J Biol Chem. 2000 Nov 10;275(45):35215-23 [10903316] J Immunol. 2001 Feb 1;166(3):1790-5 [11160225] J Neurochem. 2001 May;77(4):1168-80 [11359882] Neurosci Lett. 2001 Sep 28;311(2):105-8 [11567789] Genes Dev. 2001 Nov 15;15(22):2922-33 [11711427] Neurobiol Aging. 2002 Jul-Aug;23(4):547-53 [12009504] J Neurosci. 2003 Feb 1;23(3):876-82 [12574416] J Neurochem. 2003 Mar;84(5):997-1005 [12603824] J Lipid Res. 2003 Jun;44(6):1071-9 [12671038] Mass Spectrom Rev. 2003 Sep-Oct;22(5):332-64 [12949918] Toxicol Sci. 2004 Oct;81(2):364-70 [15254342] J Lipid Res. 1965 Oct;6(4):537-44 [5865382] Biochim Biophys Acta. 1971 Dec 3;249(2):462-92 [5134192] Science. 1992 Dec 18;258(5090):1946-9 [1470919] Glia. 1993 Jan;7(1):75-83 [8423065] J Biol Chem. 1993 Oct 25;268(30):22908-13 [8226800] Br J Anaesth. 1996 Mar;76(3):435-45 [8785147] Am J Pathol. 1997 Feb;150(2):617-30 [9033275] J Neurosci. 1997 Jul 1;17(13):5089-100 [9185546] Science. 1999 Jan 1;283(5398):70-4 [9872743] J Neurochem. 1999 Apr;72(4):1617-24 [10098869] Brain Res. 2005 Feb 21;1035(1):24-31 [15713273] Mass Spectrom Rev. 2005 May-Jun;24(3):367-412 [15389848] J Lipid Res. 2005 Jul;46(7):1548-60 [15834120] Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10858-63 [16040805] Nat Biotechnol. 2006 Sep;24(9):1151-61 [16964229] J Biol Chem. 2007 Feb 9;282(6):3614-23 [17158102] Toxicol Sci. 2007 Jul;98(1):145-58 [17426105] J Biol Chem. 2007 Jun 29;282(26):18661-5 [17488715] J Am Assoc Lab Anim Sci. 2007 Nov;46(6):21-8 [17994669] J Neurosci. 2008 Feb 13;28(7):1721-7 [18272692] Rapid Commun Mass Spectrom. 2008 Jul;22(13):2115-24 [18523984] BMC Bioinformatics. 2008;9 Suppl 9:S10 [18793455] Neurotoxicology. 2013 Dec;39:45-56 [23994303] Anesthesiology. 2014 Feb;120(2):403-15 [24061597] J Neural Transm (Vienna). 2000;107(8-9):1027-63 [11041281] J Neurosurg Anesthesiol. 2008 Oct;20(4):233-40 [18812886] Nat Neurosci. 2008 Nov;11(11):1311-8 [18931664] Anal Chem. 2009 Jun 1;81(11):4356-68 [19408941] Curr Med Chem. 2009;16(16):2021-41 [19519379] J Neuroimmunol. 2009 Jul 25;212(1-2):17-25 [19457561] Neuroscience. 2010 Mar 31;166(3):852-63 [20080153] Prostaglandins Leukot Essent Fatty Acids. 2010 Apr-Jun;82(4-6):165-72 [20207120] Anesthesiology. 2010 Jun;112(6):1404-16 [20460993] Anesthesiology. 2010 Jun;112(6):1325-34 [20460994] Biochim Biophys Acta. 2010 Aug;1801(8):774-83 [20117236] Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20936-41 [19926863] J Cell Biol. 2011 Mar 21;192(6):979-92 [21402788] Neurotoxicol Teratol. 2011 Mar-Apr;33(2):220-30 [21241795] Int J Dev Neurosci. 2011 May;29(3):351-8 [20691775] Neurotoxicol Teratol. 2011 Sep-Oct;33(5):592-7 [21708249] Neuroscience. 2012 Mar 15;205:167-77 [22244976] Anal Chem. 2012 May 15;84(10):4580-6 [22500579] Neurol Sci. 2012 Jun;33(3):535-44 [21948083] Biochim Biophys Acta. 2013 Mar;1831(3):543-54 [22960354] J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2673-95 [19269264] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv150 ER - TY - JOUR T1 - Effects of amorphous silica coating on cerium oxide nanoparticles induced pulmonary responses. AN - 1715661491; 26210349 AB - Recently cerium compounds have been used in a variety of consumer products, including diesel fuel additives, to increase fuel combustion efficiency and decrease diesel soot emissions. However, cerium oxide (CeO2) nanoparticles have been detected in the exhaust, which raises a health concern. Previous studies have shown that exposure of rats to nanoscale CeO2 by intratracheal instillation (IT) induces sustained pulmonary inflammation and fibrosis. In the present study, male Sprague-Dawley rats were exposed to CeO2 or CeO2 coated with a nano layer of amorphous SiO2 (aSiO2/CeO2) by a single IT and sacrificed at various times post-exposure to assess potential protective effects of the aSiO2 coating. The first acellular bronchoalveolar lavage (BAL) fluid and BAL cells were collected and analyzed from all exposed animals. At the low dose (0.15mg/kg), CeO2 but not aSiO2/CeO2 exposure induced inflammation. However, at the higher doses, both particles induced a dose-related inflammation, cytotoxicity, inflammatory cytokines, matrix metalloproteinase (MMP)-9, and tissue inhibitor of MMP at 1day post-exposure. Morphological analysis of lung showed an increased inflammation, surfactant and collagen fibers after CeO2 (high dose at 3.5mg/kg) treatment at 28days post-exposure. aSiO2 coating significantly reduced CeO2-induced inflammatory responses in the airspace and appeared to attenuate phospholipidosis and fibrosis. Energy dispersive X-ray spectroscopy analysis showed Ce and phosphorous (P) in all particle-exposed lungs, whereas Si was only detected in aSiO2/CeO2-exposed lungs up to 3days after exposure, suggesting that aSiO2 dissolved off the CeO2 core, and some of the CeO2 was transformed to CePO4 with time. These results demonstrate that aSiO2 coating reduce CeO2-induced inflammation, phospholipidosis and fibrosis. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Ma, Jane AU - Mercer, Robert R AU - Barger, Mark AU - Schwegler-Berry, Diane AU - Cohen, Joel M AU - Demokritou, Philip AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA. Electronic address: jym1@cdc.gov. ; Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA. ; Harvard TH Chan School of Public Health, Harvard University, Boston, MA, USA. ; School of Pharmacy, West Virginia University, Morgantown, WV, USA. Y1 - 2015/10/01/ PY - 2015 DA - 2015 Oct 01 SP - 63 EP - 73 VL - 288 IS - 1 KW - Anti-Inflammatory Agents KW - 0 KW - Cytokines KW - Inflammation Mediators KW - Phospholipids KW - Pulmonary Surfactant-Associated Proteins KW - Tissue Inhibitor of Metalloproteinases KW - Cerium KW - 30K4522N6T KW - ceric oxide KW - 619G5K328Y KW - Silicon Dioxide KW - 7631-86-9 KW - Collagen KW - 9007-34-5 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Mmp9 protein, rat KW - Index Medicus KW - Safer by design KW - Lung inflammation KW - Pulmonary fibrosis KW - Cerium oxide, amorphous silica KW - Animals KW - Spectrometry, X-Ray Emission KW - Collagen -- metabolism KW - Dose-Response Relationship, Drug KW - Tissue Inhibitor of Metalloproteinases -- metabolism KW - Phospholipids -- metabolism KW - Cytoprotection KW - Cytokines -- metabolism KW - Inflammation Mediators -- metabolism KW - Matrix Metalloproteinase 9 -- metabolism KW - Rats, Sprague-Dawley KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Pulmonary Surfactant-Associated Proteins -- metabolism KW - Time Factors KW - Male KW - Surface Properties KW - Silicon Dioxide -- pharmacology KW - Pneumonia -- prevention & control KW - Pneumonia -- chemically induced KW - Metal Nanoparticles -- chemistry KW - Metal Nanoparticles -- toxicity KW - Lung -- metabolism KW - Lung -- pathology KW - Cerium -- chemistry KW - Cerium -- toxicity KW - Silicon Dioxide -- chemistry KW - Pneumonia -- pathology KW - Pulmonary Fibrosis -- metabolism KW - Anti-Inflammatory Agents -- chemistry KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Pulmonary Fibrosis -- prevention & control KW - Lung -- drug effects KW - Pneumonia -- metabolism KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1715661491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Effects+of+amorphous+silica+coating+on+cerium+oxide+nanoparticles+induced+pulmonary+responses.&rft.au=Ma%2C+Jane%3BMercer%2C+Robert+R%3BBarger%2C+Mark%3BSchwegler-Berry%2C+Diane%3BCohen%2C+Joel+M%3BDemokritou%2C+Philip%3BCastranova%2C+Vincent&rft.aulast=Ma&rft.aufirst=Jane&rft.date=2015-10-01&rft.volume=288&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.07.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-15 N1 - Date created - 2015-09-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2014 Jul 15;278(2):135-47 [24793434] Environ Health Perspect. 2007 May;115(5):728-33 [17520060] Toxicol Sci. 2014 Dec;142(2):403-17 [25239632] Am J Physiol Lung Cell Mol Physiol. 2000 Sep;279(3):L562-74 [10956632] Toxicol Sci. 2000 May;55(1):24-35 [10788556] J Trace Elem Med Biol. 2001 Apr;14(4):232-6 [11396783] Environ Health Perspect. 2001 May;109(5):515-21 [11401764] Arch Toxicol. 2002 Jan;75(11-12):625-34 [11876495] Histochem J. 1979 Jul;11(4):447-55 [91593] Sci Total Environ. 1982 Dec;26(1):19-32 [7167813] Fundam Appl Toxicol. 1985 Apr;5(2):240-50 [2580752] Am J Ind Med. 1995 Mar;27(3):349-58 [7747741] Mod Pathol. 1995 Oct;8(8):859-65 [8552576] Scand J Work Environ Health. 1995;21 Suppl 2:19-21 [8929682] Microsc Res Tech. 1997 Feb 15;36(4):313-23 [9140931] Toxicol Lett. 2007 Dec 10;175(1-3):24-33 [17981407] Curr Opin Biotechnol. 2007 Dec;18(6):565-71 [18160274] Anal Chim Acta. 2009 Oct 27;653(2):191-9 [19808113] Ind Health. 2010;48(1):3-11 [20160402] Nanotechnology. 2010 Jul 16;21(28):285103 [20562477] Toxicol Lett. 2011 Aug 28;205(2):105-15 [21624445] Nanotoxicology. 2011 Sep;5(3):312-25 [20925443] Int J Nanomedicine. 2011;6:2327-35 [22072870] Environ Res. 2012 May;115:1-10 [22507957] Toxicol Appl Pharmacol. 2012 Aug 1;262(3):255-64 [22613087] Nanotoxicology. 2014 Aug;8 Suppl 1:216-25 [24479615] Am J Respir Cell Mol Biol. 1999 May;20(5):903-13 [10226060] Toxicol Ind Health. 2004 Jun;20(1-5):21-7 [15807405] Eur J Pharmacol. 2006 Mar 8;533(1-3):133-44 [16487964] Nanotoxicology. 2013 Dec;7(8):1338-50 [23061914] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.07.012 ER - TY - JOUR T1 - Establishing best practise in the application of expert review of mutagenicity under ICH M7. AN - 1712523189; 26248005 AB - The ICH M7 guidelines for the assessment and control of DNA reactive (mutagenic) impurities in pharmaceuticals allows for the consideration of in silico predictions in place of in vitro studies. This represents a significant advance in the acceptance of (Q)SAR models and has resulted from positive interactions between modellers, regulatory agencies and industry with a shared purpose of developing effective processes to minimise risk. This paper discusses key scientific principles that should be applied when evaluating in silico predictions with a focus on accuracy and scientific rigour that will support a consistent and practical route to regulatory submission. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Barber, Chris AU - Amberg, Alexander AU - Custer, Laura AU - Dobo, Krista L AU - Glowienke, Susanne AU - Van Gompel, Jacky AU - Gutsell, Steve AU - Harvey, Jim AU - Honma, Masamitsu AU - Kenyon, Michelle O AU - Kruhlak, Naomi AU - Muster, Wolfgang AU - Stavitskaya, Lidiya AU - Teasdale, Andrew AU - Vessey, Jonathan AU - Wichard, Joerg AD - Lhasa Limited, Leeds, UK. Electronic address: chris.barber@lhasalimited.org. ; Sanofi-Aventis Deutschland GmbH, DSAR Preclinical Safety, Frankfurt, Germany. ; Bristol-Myers Squibb, Drug Safety Evaluation, New Brunswick, USA. ; Pfizer, Drug Safety Research and Development, Groton, CT, USA. ; Novartis Institutes for Biomedical Research, Department of Preclinical Safety, Basel, Switzerland. ; Janssen, Drug Safety Sciences, Beerse, Belgium. ; Unilever, Safety and Environmental Assurance Centre, Colworth, Beds, UK. ; GlaxoSmithkline, Computational Toxicology, Ware, Herts, UK. ; National Institute of Health Sciences, Tokyo, Japan. ; FDA Center for Drug Evaluation and Research, Silver Spring, MD, USA. ; F. Hoffmann-La Roche Ltd., Pharma Research and Early Development, Basel, Switzerland. ; AstraZeneca, Macclesfield, Cheshire, UK. ; Lhasa Limited, Leeds, UK. ; Bayer, HealthCare, Genetic Toxicology, Berlin, Germany. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 367 EP - 377 VL - 73 IS - 1 KW - Mutagens KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - In silico KW - ICH M7 KW - Statistical KW - Mutagenicity KW - Expert rule-based KW - Genotoxicity KW - Ames KW - Drug Contamination -- prevention & control KW - Quantitative Structure-Activity Relationship KW - Computer Simulation -- standards KW - DNA -- chemistry KW - Mutagenicity Tests -- methods KW - Mutagenicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712523189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Establishing+best+practise+in+the+application+of+expert+review+of+mutagenicity+under+ICH+M7.&rft.au=Barber%2C+Chris%3BAmberg%2C+Alexander%3BCuster%2C+Laura%3BDobo%2C+Krista+L%3BGlowienke%2C+Susanne%3BVan+Gompel%2C+Jacky%3BGutsell%2C+Steve%3BHarvey%2C+Jim%3BHonma%2C+Masamitsu%3BKenyon%2C+Michelle+O%3BKruhlak%2C+Naomi%3BMuster%2C+Wolfgang%3BStavitskaya%2C+Lidiya%3BTeasdale%2C+Andrew%3BVessey%2C+Jonathan%3BWichard%2C+Joerg&rft.aulast=Barber&rft.aufirst=Chris&rft.date=2015-10-01&rft.volume=73&rft.issue=1&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.07.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-28 N1 - Date created - 2015-09-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.07.018 ER - TY - JOUR T1 - Bayesian evaluation of a physiologically-based pharmacokinetic (PBPK) model of long-term kinetics of metal nanoparticles in rats. AN - 1712522678; 26145831 AB - Biomathematical modeling quantitatively describes the disposition of metal nanoparticles in lungs and other organs of rats. In a preliminary model, adjustable parameters were calibrated to each of three data sets using a deterministic approach, with optimal values varying among the different data sets. In the current effort, Bayesian population analysis using Markov chain Monte Carlo (MCMC) simulation was used to recalibrate the model while improving assessments of parameter variability and uncertainty. The previously-developed model structure and some physiological parameter values were modified to improve physiological realism. The data from one of the three previously-identified studies and from two other studies were used for model calibration. The data from the one study that adequately characterized mass balance were used to generate parameter distributions. When data from a second study of the same nanomaterial (iridium) were added, the level of agreement was still acceptable. Addition of another data set (for silver nanoparticles) led to substantially lower precision in parameter estimates and large discrepancies between the model predictions and experimental data for silver nanoparticles. Additional toxicokinetic data are needed to further evaluate the model structure and performance and to reduce uncertainty in the kinetic processes governing in vivo disposition of metal nanoparticles. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Sweeney, Lisa M AU - MacCalman, Laura AU - Haber, Lynne T AU - Kuempel, Eileen D AU - Tran, C Lang AD - Henry M. Jackson Foundation for the Advancement of Military Medicine, Naval Medical Research Unit Dayton (NAMRU Dayton), 2729 R Street, Building 837, Wright Patterson Air Force Base, OH 45433, USA; Toxicology Excellence for Risk Assessment (TERA), 2300 Montana Avenue, Cincinnati, OH 45211, USA. Electronic address: LMS29@cwru.edu. ; Institute of Occupational Medicine, Research Avenue North, Riccarton, Edinburgh EH14 4AP, UK. ; Toxicology Excellence for Risk Assessment (TERA), 2300 Montana Avenue, Cincinnati, OH 45211, USA. ; National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Parkway, M.S. C-15, Cincinnati, OH 45226-1998, USA. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 151 EP - 163 VL - 73 IS - 1 KW - Index Medicus KW - Physiologically-based pharmacokinetic model KW - Bayesian analysis KW - Nanoparticles KW - Markov chain Monte Carlo KW - Rats KW - Uncertainty KW - Animals KW - Kinetics KW - Rats, Wistar KW - Bayes Theorem KW - Calibration KW - Markov Chains KW - Monte Carlo Method KW - Models, Biological KW - Male KW - Models, Theoretical KW - Metal Nanoparticles -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712522678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Bayesian+evaluation+of+a+physiologically-based+pharmacokinetic+%28PBPK%29+model+of+long-term+kinetics+of+metal+nanoparticles+in+rats.&rft.au=Sweeney%2C+Lisa+M%3BMacCalman%2C+Laura%3BHaber%2C+Lynne+T%3BKuempel%2C+Eileen+D%3BTran%2C+C+Lang&rft.aulast=Sweeney&rft.aufirst=Lisa&rft.date=2015-10-01&rft.volume=73&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.06.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-28 N1 - Date created - 2015-09-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2000 Feb 15;163(1):67-74 [10662606] J Pharmacokinet Pharmacodyn. 2009 Feb;36(1):19-38 [19132515] Toxicol Lett. 2009 May 8;186(3):152-9 [19114093] Toxicol Appl Pharmacol. 2009 May 1;236(3):329-40 [19249323] Inhal Toxicol. 2009 Jul;21 Suppl 1:55-60 [19558234] Toxicology. 2009 Sep 19;263(2-3):117-26 [19615422] Toxicol Appl Pharmacol. 2009 Nov 15;241(1):36-60 [19660485] Inhal Toxicol. 2009 Nov;21(13):1099-107 [19814607] Biomaterials. 2010 Nov;31(32):8350-61 [20684985] Toxicol Sci. 2010 Dec;118(2):470-84 [20833708] ACS Nano. 2010 Nov 23;4(11):6303-17 [20945925] J Nanosci Nanotechnol. 2010 Dec;10(12):8482-90 [21121357] Nat Biotechnol. 2010 Dec;28(12):1300-3 [21057497] Int J Nanomedicine. 2012;7:1345-56 [22419876] J Appl Toxicol. 2012 Nov;32(11):920-8 [22696427] Int J Nanomedicine. 2013;8:3365-82 [24039420] Nanotoxicology. 2014 Mar;8(2):132-41 [23272772] J Toxicol Environ Health A. 2000 Aug 25;60(8):531-48 [10983521] Environ Health Perspect. 2000 Oct;108 Suppl 5:883-93 [11035998] Environ Health Perspect. 2001 Aug;109 Suppl 4:547-51 [11544161] J Toxicol Environ Health A. 2002 Oct 25;65(20):1513-30 [12396866] Toxicol Lett. 2003 Feb 18;138(1-2):143-50 [12559698] Inhal Toxicol. 2004 Jun;16(6-7):453-9 [15204761] Gut. 1989 Apr;30(4):455-9 [2714679] Toxicol Lett. 1994 Dec;74(3):189-201 [7871543] Cancer Res. 1996 Aug 15;56(16):3771-81 [8706023] Risk Anal. 2004 Dec;24(6):1697-717 [15660623] Toxicology. 2006 Apr 17;221(2-3):241-8 [16466842] Regul Toxicol Pharmacol. 2006 Oct;46(1):63-83 [16889879] Environ Health Perspect. 2007 May;115(5):728-33 [17520060] Nat Biotechnol. 2007 Oct;25(10):1165-70 [17891134] Arch Toxicol. 2008 Mar;82(3):151-7 [18000654] Toxicol Sci. 2009 Feb;107(2):342-51 [19023088] Nanotoxicology. 2014 Aug;8 Suppl 1:128-37 [24392664] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.06.019 ER - TY - JOUR T1 - Chronic MPTP treatment produces hyperactivity in male mice which is not alleviated by concurrent trehalose treatment. AN - 1709396567; 26111725 AB - The chronic MPTP+probenecid treatment paradigm has been used to successfully model the neurochemical, neuropathological, and behavioral effects associated with Parkinson's disease. Here, adult male C57Bl/6 mice were injected ip with 25 mg/kg MPTP and 250 mg/kg probenecid (MPTPp) or saline twice weekly for a total of 10 injections. Behavioral assessments included motor coordination, grip strength, spatial learning/memory, locomotor activity, and anhedonia. Those assessments were repeated up to 8 weeks post-treatment. In a subsequent experiment, adult male mice were treated with saline or MPTPp as described above. One-half of each group was allowed access to 1% trehalose in the water bottle. Trehalose intake averaged 1.90-2.34 g/kg. Behavioral assessments included locomotor activity, olfaction, motor coordination, grip strength, and exploratory behavior. Those assessments were repeated 4 weeks post-treatment. The strongest MPTPp effect was hyperactivity as exhibited in the open field. This increased activity was apparent in both experiments and occurred at all time points post-treatment. Assessments of grip strength, water maze performance, olfaction, and exploratory behavior did not indicate MPTPp-related alterations. When the specifications for the motor coordination test were made somewhat easier in the second experiment, there were deficits exhibited by the MPTPp group, the MPTPp+trehalose group and the trehalose group. The addition of trehalose did not alleviate any of the MPTPp-induced behavioral alterations; however, trehalose treatment significantly attenuated the striatal decreases in DA, DOPAC, HVA and 5-HIAA. These results provide a more comprehensive description of the behavioral alterations resulting from the chronic MPTPp treatment regimen and suggest that trehalose at this concentration does not act as a complete neuroprotectant. Published by Elsevier B.V. JF - Behavioural brain research AU - Ferguson, Sherry A AU - Law, C Delbert AU - Sarkar, Sumit AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA. Electronic address: Sherry.Ferguson@fda.hhs.gov. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA. Electronic address: Charles.Law@fda.hhs.gov. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA. Electronic address: Sumit.Sarkar@fda.hhs.gov. Y1 - 2015/10/01/ PY - 2015 DA - 2015 Oct 01 SP - 68 EP - 78 VL - 292 KW - Neuroprotective Agents KW - 0 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Trehalose KW - B8WCK70T7I KW - Probenecid KW - PO572Z7917 KW - Index Medicus KW - Parkinson’s disease KW - Behavior KW - MPTP KW - Locomotor activity KW - Mice KW - Behavior, Animal -- drug effects KW - Animals KW - Probenecid -- administration & dosage KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Motor Activity -- drug effects KW - Male KW - Neuroprotective Agents -- pharmacology KW - MPTP Poisoning -- drug therapy KW - Trehalose -- pharmacology KW - Hyperkinesis -- chemically induced KW - Hyperkinesis -- drug therapy KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- administration & dosage KW - MPTP Poisoning -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709396567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioural+brain+research&rft.atitle=Chronic+MPTP+treatment+produces+hyperactivity+in+male+mice+which+is+not+alleviated+by+concurrent+trehalose+treatment.&rft.au=Ferguson%2C+Sherry+A%3BLaw%2C+C+Delbert%3BSarkar%2C+Sumit&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2015-10-01&rft.volume=292&rft.issue=&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Behavioural+brain+research&rft.issn=1872-7549&rft_id=info:doi/10.1016%2Fj.bbr.2015.05.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-14 N1 - Date created - 2015-09-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bbr.2015.05.057 ER - TY - JOUR T1 - Ketamine-Induced Toxicity in Neurons Differentiated from Neural Stem Cells. AN - 1709395554; 26055230 AB - Ketamine is used as a general anesthetic, and recent data suggest that anesthetics can cause neuronal damage when exposure occurs during development. The precise mechanisms are not completely understood. To evaluate the degree of ketamine-induced neuronal toxicity, neural stem cells were isolated from gestational day 16 rat fetuses. On the eighth day in culture, proliferating neural stem cells were exposed for 24 h to ketamine at 1, 10, 100, and 500 μM. To determine the effect of ketamine on differentiated stem cells, separate cultures of neural stem cells were maintained in transition medium (DIV 6) for 1 day and kept in differentiation medium for another 3 days. Differentiated neural cells were exposed for 24 h to 10 μM ketamine. Markers of cellular proliferation and differentiation, mitochondrial health, cell death/damage, and oxidative damage were monitored to determine: (1) the effects of ketamine on neural stem cell proliferation and neural stem cell differentiation; (2) the nature and degree of ketamine-induced toxicity in proliferating neural stem cells and differentiated neural cells; and (3) to provide information regarding receptor expression and possible mechanisms underlying ketamine toxicity. After ketamine exposure at a clinically relevant concentration (10 μM), neural stem cell proliferation was not significantly affected and oxidative DNA damage was not induced. No significant effect on mitochondrial viability (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay) in neural stem cell cultures (growth medium) was observed at ketamine concentrations up to 500 μM. However, quantitative analysis shows that the number of differentiated neurons was substantially reduced in 10 μM ketamine-exposed cultures in differentiation medium, compared with the controls. No significant changes in the number of GFAP-positive astrocytes and O4-positive oligodendrocytes (in differentiation medium) were detected from ketamine-exposed cultures. The discussion focuses on: (1) the doses and time-course over which ketamine is associated with damage of neural cells; (2) how ketamine directs or signals neural stem cells/neural cells to undergo apoptosis or necrosis; (3) how functional neuronal transmitter receptors affect neurotoxicity induced by ketamine; and (4) advantages of using neural stem cell models to study critical issues related to ketamine anesthesia. JF - Molecular neurobiology AU - Slikker, William AU - Liu, Fang AU - Rainosek, Shuo W AU - Patterson, Tucker A AU - Sadovova, Natalya AU - Hanig, Joseph P AU - Paule, Merle G AU - Wang, Cheng AD - Office of the Director, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR, 72079, USA, William.slikker@fda.hhs.gov. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 959 EP - 969 VL - 52 IS - 2 KW - Culture Media KW - 0 KW - Intercellular Signaling Peptides and Proteins KW - N-Methylaspartate KW - 6384-92-5 KW - Ketamine KW - 690G0D6V8H KW - Calcium KW - SY7Q814VUP KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Cerebral Cortex -- cytology KW - Animals KW - Oligodendroglia -- drug effects KW - DNA Damage KW - Astrocytes -- drug effects KW - Nerve Degeneration -- chemically induced KW - Intercellular Signaling Peptides and Proteins -- pharmacology KW - Culture Media -- pharmacology KW - Calcium -- metabolism KW - Rats KW - Necrosis KW - Cerebral Cortex -- embryology KW - Glycine -- pharmacology KW - Apoptosis -- drug effects KW - Mitochondria -- drug effects KW - Nerve Degeneration -- pathology KW - Astrocytes -- cytology KW - Dose-Response Relationship, Drug KW - Cell Division -- drug effects KW - Neurogenesis -- drug effects KW - Oligodendroglia -- cytology KW - Rats, Sprague-Dawley KW - Extracellular Fluid -- metabolism KW - Cells, Cultured KW - N-Methylaspartate -- pharmacology KW - Ketamine -- toxicity KW - Neurons -- drug effects KW - Neurons -- cytology KW - Neural Stem Cells -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709395554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+neurobiology&rft.atitle=Ketamine-Induced+Toxicity+in+Neurons+Differentiated+from+Neural+Stem+Cells.&rft.au=Slikker%2C+William%3BLiu%2C+Fang%3BRainosek%2C+Shuo+W%3BPatterson%2C+Tucker+A%3BSadovova%2C+Natalya%3BHanig%2C+Joseph+P%3BPaule%2C+Merle+G%3BWang%2C+Cheng&rft.aulast=Slikker&rft.aufirst=William&rft.date=2015-10-01&rft.volume=52&rft.issue=2&rft.spage=959&rft.isbn=&rft.btitle=&rft.title=Molecular+neurobiology&rft.issn=1559-1182&rft_id=info:doi/10.1007%2Fs12035-015-9248-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-21 N1 - Date created - 2015-09-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s12035-015-9248-5 ER - TY - JOUR T1 - Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage. AN - 1709395553; 26099304 AB - Various iron-oxide nanoparticles have been in use for a long time as therapeutic and imaging agents and for supplemental delivery in cases of iron-deficiency. While all of these products have a specified size range of ∼ 40 nm and above, efforts are underway to produce smaller particles, down to ∼ 1 nm. Here, we show that after a 24-h exposure of SHSY-5Y human neuroblastoma cells to 10 μg/ml of 10 and 30 nm ferric oxide nanoparticles (Fe-NPs), cellular dopamine content was depleted by 68 and 52 %, respectively. Increases in activated tyrosine kinase c-Abl, a molecular switch induced by oxidative stress, and neuronal α-synuclein expression, a protein marker associated with neuronal injury, were also observed (55 and 38 % percent increases, respectively). Inhibition of cell-proliferation, significant reductions in the number of active mitochondria, and a dose-dependent increase in reactive oxygen species (ROS) were observed in neuronal cells. Additionally, using a rat in vitro blood-brain barrier (BBB) model, a dose-dependent increase in ROS accompanied by increased fluorescein efflux demonstrated compromised BBB integrity. To assess translational implications, in vivo Fe-NP-induced neurotoxicity was determined using in vivo MRI and post-mortem neurochemical and neuropathological correlates in adult male rats after exposure to 50 mg/kg of 10 nm Fe-NPs. Significant decrease in T 2 values was observed. Dynamic observations suggested transfer and retention of Fe-NPs from brain vasculature into brain ventricles. A significant decrease in striatal dopamine and its metabolites was also observed, and neuropathological correlates provided additional evidence of significant nerve cell body and dopaminergic terminal damage as well as damage to neuronal vasculature after exposure to 10 nm Fe-NPs. These data demonstrate a neurotoxic potential of very small size iron nanoparticles and suggest that use of these ferric oxide nanoparticles may result in neurotoxicity, thereby limiting their clinical application. JF - Molecular neurobiology AU - Imam, Syed Z AU - Lantz-McPeak, Susan M AU - Cuevas, Elvis AU - Rosas-Hernandez, Hector AU - Liachenko, Serguei AU - Zhang, Yongbin AU - Sarkar, Sumit AU - Ramu, Jaivijay AU - Robinson, Bonnie L AU - Jones, Yvonne AU - Gough, Bobby AU - Paule, Merle G AU - Ali, Syed F AU - Binienda, Zbigniew K AD - Division of Neurotoxicology, US FDA/National Center for Toxicological Research, Jefferson, AR, USA, Syed.Imam@fda.hhs.gov. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 913 EP - 926 VL - 52 IS - 2 KW - Catecholamines KW - 0 KW - Magnetite Nanoparticles KW - Reactive Oxygen Species KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Neuroblastoma -- pathology KW - Magnetic Resonance Imaging KW - Animals KW - Spectrometry, X-Ray Emission KW - Nanospheres KW - Particle Size KW - Humans KW - Cell Division -- drug effects KW - Cell Line, Tumor KW - Reactive Oxygen Species -- analysis KW - Caspases -- metabolism KW - Magnetic Resonance Spectroscopy KW - Rats KW - Blood-Brain Barrier -- drug effects KW - Permeability -- drug effects KW - Rats, Sprague-Dawley KW - Corpus Striatum -- chemistry KW - Oxidative Stress KW - Mitochondria -- drug effects KW - Apoptosis -- drug effects KW - Enzyme Activation -- drug effects KW - Mitochondria -- metabolism KW - Corpus Striatum -- drug effects KW - Catecholamines -- analysis KW - Male KW - Dopaminergic Neurons -- drug effects KW - Dopaminergic Neurons -- chemistry KW - Magnetite Nanoparticles -- toxicity KW - Dopaminergic Neurons -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709395553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+BROMODICHLOROACETIC+ACID+%28CAS+NO.+71133-14-7%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+BROMODICHLOROACETIC+ACID+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-10-01&rft.volume=&rft.issue=583&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-21 N1 - Date created - 2015-09-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s12035-015-9259-2 ER - TY - JOUR T1 - Pharmacokinetics of bisphenol A in humans following a single oral administration. AN - 1705735125; 26115537 AB - Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA. To reduce uncertainties about the metabolism and excretion of BPA in humans following oral administration. We exposed six men and eight women to 100 μg/kg bw of deuterated BPA (d6-BPA) by oral administration and conducted blood and urine analysis over a three day period. The use of d6-BPA allowed administered d6-BPA to be distinguished from background native (unlabeled) BPA. We calculated the rate of oral absorption, serum elimination, half-life, area under the curve (AUC), urinary excretion, and metabolism to glucuronide and sulfate conjugates. Mean serum total (unconjugated and conjugated) d6-BPA Cmax of 1711 nM (390 ng/ml) was observed at Tmax of 1.1 ± 0.50h. Unconjugated d6-BPA appeared in serum within 5-20 min of dosing with a mean Cmax of 6.5 nM (1.5 ng/ml) observed at Tmax of 1.3 ± 0.52 h. Detectable blood levels of unconjugated or total d6-BPA were observed at 48 h in some subjects at concentrations near the LOD (0.001-0.002 ng/ml). The half-times for terminal elimination of total d6-BPA and unconjugated d6-BPA were 6.4 ± 2.0 h and 6.2 ± 2.6h, respectively. Recovery of total administered d6-BPA in urine was 84-109%. Most subjects (10 of 14) excreted >90% as metabolites within 24h. Using more sensitive methods, our study expands the findings of other human oral pharmacokinetic studies. Conjugation reactions are rapid and nearly complete with unconjugated BPA comprising less than 1% of the total d6-BPA in blood at all times. Elimination of conjugates into urine largely occurs within 24h. Published by Elsevier Ltd. JF - Environment international AU - Thayer, Kristina A AU - Doerge, Daniel R AU - Hunt, Dawn AU - Schurman, Shepherd H AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Garantziotis, Stavros AU - Kissling, Grace E AU - Easterling, Michael R AU - Bucher, John R AU - Birnbaum, Linda S AD - Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA. Electronic address: thayer@niehs.nih.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, NCTR-53C RM204L HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: daniel.doerge@fda.hhs.gov. ; Clinical Research Unit, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop CU-01, Research Triangle Park, NC 27709, USA. Electronic address: dawnhunt2233@outlook.com. ; Clinical Research Unit, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop CU-01, Research Triangle Park, NC 27709, USA. Electronic address: schurmansh@niehs.nih.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, NCTR-53C RM204L HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: Nathan.Twaddle@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food & Drug Administration, NCTR-53C RM204L HFT-110, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: Mona.Churchwell@fda.hhs.gov. ; Clinical Research Unit, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop CU-01, Research Triangle Park, NC 27709, USA. Electronic address: garantziotis@niehs.nih.gov. ; Biostatistics Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, Mail Drop A3-03, Research Triangle Park, NC 27709, USA. Electronic address: kissling@niehs.nih.gov. ; Social & Scientific Systems, Inc., 1009 Slater Rd # 120, Durham, NC 27703, USA. Electronic address: MEasterling@s-3.com. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop K2-02, Research Triangle Park, NC 27709, USA. Electronic address: bucher@niehs.nih.gov. ; National Cancer Institute, National Institutes of Health, Department of Health and Human Services, P.O. Box 12233, Mail Drop B2-01, Research Triangle Park, NC 27709, USA. Electronic address: birnbaumls@niehs.nih.gov. Y1 - 2015/10// PY - 2015 DA - October 2015 SP - 107 EP - 115 VL - 83 KW - Benzhydryl Compounds KW - 0 KW - Environmental Pollutants KW - Glucuronides KW - Phenols KW - Sulfuric Acid Esters KW - bisphenol A glucuronide KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Bioavailability KW - ADME KW - Endocrine disruptor KW - Excretion KW - Metabolism KW - Deuterated bisphenol A KW - Administration, Oral KW - Sulfuric Acid Esters -- urine KW - Half-Life KW - Area Under Curve KW - Humans KW - North Carolina KW - Adult KW - Middle Aged KW - Glucuronides -- blood KW - Sulfuric Acid Esters -- blood KW - Glucuronides -- urine KW - Male KW - Female KW - Benzhydryl Compounds -- pharmacokinetics KW - Phenols -- blood KW - Phenols -- pharmacokinetics KW - Environmental Pollutants -- urine KW - Benzhydryl Compounds -- blood KW - Phenols -- urine KW - Environmental Pollutants -- blood KW - Environmental Pollutants -- pharmacokinetics KW - Benzhydryl Compounds -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705735125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Pharmacokinetics+of+bisphenol+A+in+humans+following+a+single+oral+administration.&rft.au=Thayer%2C+Kristina+A%3BDoerge%2C+Daniel+R%3BHunt%2C+Dawn%3BSchurman%2C+Shepherd+H%3BTwaddle%2C+Nathan+C%3BChurchwell%2C+Mona+I%3BGarantziotis%2C+Stavros%3BKissling%2C+Grace+E%3BEasterling%2C+Michael+R%3BBucher%2C+John+R%3BBirnbaum%2C+Linda+S&rft.aulast=Thayer&rft.aufirst=Kristina&rft.date=2015-10-01&rft.volume=43&rft.issue=7&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623315596382 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-04 N1 - Date created - 2015-08-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2010 Oct 1;248(1):1-11 [20655935] Anal Bioanal Chem. 2010 Sep;398(1):571-6 [20623271] Toxicol Appl Pharmacol. 2010 Sep 1;247(2):158-65 [20600215] Xenobiotica. 2010 Feb;40(2):83-92 [19916736] Philos Trans R Soc Lond B Biol Sci. 2009 Jul 27;364(1526):2063-78 [19528056] Environ Health Perspect. 2009 May;117(5):784-9 [19479022] Toxicol Appl Pharmacol. 2015 Oct 15;288(2):131-42 [25620055] NTP CERHR MON. 2008 Sep;(22):v, vii-ix, 1-64 passim [19407859] Birth Defects Res B Dev Reprod Toxicol. 2008 Jun;83(3):157-395 [18613034] Toxicol Appl Pharmacol. 2008 Apr 1;228(1):114-34 [18207480] Environ Health Perspect. 2008 Jan;116(1):39-44 [18197297] Reprod Toxicol. 2007 Aug-Sep;24(2):139-77 [17825522] Chem Res Toxicol. 2002 Oct;15(10):1281-7 [12387626] AIHAJ. 2000 Sep-Oct;61(5):649-57 [11071416] Rapid Commun Mass Spectrom. 2010 Oct 30;24(20):3011-20 [20872634] Environ Health Perspect. 2011 Apr;119(4):422-30 [20855240] Toxicol Lett. 2011 Jul 28;204(2-3):190-8 [21571050] Toxicol Appl Pharmacol. 2011 Sep 15;255(3):261-70 [21820460] Arch Toxicol. 2011 Nov;85(11):1373-81 [21404072] Toxicol Lett. 2011 Dec 15;207(3):298-305 [21983029] Clin Pharmacokinet. 2012 May 1;51(5):319-30 [22439649] J Expo Sci Environ Epidemiol. 2012 Nov;22(6):610-6 [22617719] Environ Health Perspect. 2013 Mar;121(3):283-6 [23458838] J Anal Toxicol. 2007 Apr;31(3):177-8 [17598284] Mol Cell Endocrinol. 2014 Dec;398(1-2):101-13 [25304273] PLoS One. 2014;9(10):e110509 [25337790] Toxicol Sci. 2014 Sep;141(1):292-9 [24980262] Environ Health. 2014;13(1):25 [24690217] Reprod Toxicol. 2014 Jun;45:105-16 [24582107] Environ Health Perspect. 2009 Apr;117(4):639-44 [19440505] Breast Cancer Res. 2013;15(5):403 [24083327] Environ Res. 2014 Feb;129:32-8 [24529000] Food Chem Toxicol. 2013 Dec;62:949-63 [23959105] Environ Sci Technol. 2013;47(21):12477-85 [23941471] Environ Res. 2013 Oct;126:211-4 [23899777] Environ Health Perspect. 2013 Aug;121(8):951-6 [23761051] Rev Environ Health. 2013;28(1):37-58 [23612528] Toxicol Sci. 2014 May;139(1):4-20 [24496641] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2015.06.008 ER - TY - JOUR T1 - Chemical exposures in the workplace and breast cancer risk: A prospective cohort study AN - 1701481821; PQ0001761735 AB - We investigated the relationship between workplace chemical exposures and breast cancer risk among women enrolled in the Sister Study, a prospective cohort study of US and Puerto Rican women. A total of 47,640 participants reported work outside of the home. Workplace exposure to eleven agents (acids, dyes or inks, gasoline or other petroleum products, glues or adhesives, lubricating oils, metals, paints, pesticides, soldering materials, solvents and stains or varnishes) was characterized based on self-reports of frequency and duration of use. Approximately 14% of the study population reported exposure to only one agent and 11% reported working with two or more of the 11 agents in their lifetime. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for each agent, adjusting for established breast cancer risk factors. During follow-up, 1,966 cases of breast cancer were reported. Although there were no significant associations between ever use of the eleven agents evaluated and breast cancer risk, women with cumulative exposure to gasoline or petroleum products at or above the highest quartile cutoff had an elevated risk of total (HR: 2.3, 95%CI: 1.1-4.9) and invasive (HR: 2.5, 95%CI: 1.1-5.9) breast cancer compared with women in the lowest quartile group (p sub(trend)=0.03). Workplace exposure to soldering materials was associated with an increased risk of premenopausal breast cancer (HR=1.8, 95% CI=1.1-3.0). Findings support the need for further studies to elucidate the role of occupational chemicals in breast cancer etiology. What's new? There has been widespread interest in the role of chemical exposures in the development of breast cancer, but few occupational studies have prospectively investigated breast cancer risk. The workplace is a setting where there is the potential for greater than background levels of exposure. Here, the authors investigate the association between workplace chemical exposures and incident breast cancer in 47,640 women enrolled in the Sister Study. They observe significant trends in breast cancer risk associated with increased gasoline/petroleum product use, suggesting that additional studies are warranted to examine the influence of occupational chemical exposures on breast cancer etiology. JF - International Journal of Cancer AU - Ekenga, Christine C AU - Parks, Christine G AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC. Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 1765 EP - 1774 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 137 IS - 7 SN - 0020-7136, 0020-7136 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Soldering KW - Invasiveness KW - Gasoline KW - Stains KW - Petroleum KW - Risk factors KW - Adhesives KW - Occupational exposure KW - Metals KW - Etiology KW - Solvents KW - Oils KW - Population studies KW - Cancer KW - Health risks KW - Dyes KW - Acids KW - Background levels KW - Pesticides KW - Breast cancer KW - Paints KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701481821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Chemical+exposures+in+the+workplace+and+breast+cancer+risk%3A+A+prospective+cohort+study&rft.au=Ekenga%2C+Christine+C%3BParks%2C+Christine+G%3BSandler%2C+Dale+P&rft.aulast=Ekenga&rft.aufirst=Christine&rft.date=2015-10-01&rft.volume=137&rft.issue=7&rft.spage=1765&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.29545 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-09-30 N1 - SubjectsTermNotLitGenreText - Soldering; Metals; Etiology; Invasiveness; Gasoline; Oils; Solvents; Population studies; Stains; Dyes; Risk factors; Acids; Petroleum; Pesticides; Background levels; Breast cancer; Adhesives; Occupational exposure; Paints; Cancer; Health risks DO - http://dx.doi.org/10.1002/ijc.29545 ER - TY - JOUR T1 - Perspectives on Communication and Participation in Research Notification Focus Groups AN - 1698868282 AB - Researchers are slowly acknowledging an ethical obligation to inform research participants about study findings. Research notification may help participants become aware of and manage potential health risks. Scholars and practitioners have acknowledged the need for better understanding of this process. This study investigates transcripts of focus groups conducted to gauge audience reactions to notification materials that communicate scientific research findings about occupational exposures. Focus groups are a useful way to tailor notification materials to audiences, but we caution that transmission models of communication used in risk research may obscure the full value of focus groups. The emphasis on translating scientific communication into “lay” language may overlook how scientists and lay audiences can work together to bridge differences in language, experiences, goals, and orientations toward health. This study demonstrates limitations in scientific risk communication that minimize participation in communicating science. The conclusion provides instructive insights for strengthening the process of communicating science. JF - Health Communication AU - Zoller, Heather M AU - Fujishiro, Kaori AU - Mobley, Amy AU - Lehman, Everett AD - Department of Communication, University of Cincinnati, Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health ; Department of Communication, University of Cincinnati; Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health Y1 - 2015/10// PY - 2015 DA - Oct 2015 SP - 986 EP - 1000 CY - Mahwah PB - Taylor & Francis Ltd. VL - 30 IS - 10 SN - 1041-0236 KW - Public Health And Safety KW - Audiences KW - Health risks KW - Medical research KW - Notification KW - Risk communication KW - Scientific research UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698868282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Communication&rft.atitle=Perspectives+on+Communication+and+Participation+in+Research+Notification+Focus+Groups&rft.au=Zoller%2C+Heather+M%3BFujishiro%2C+Kaori%3BMobley%2C+Amy%3BLehman%2C+Everett&rft.aulast=Zoller&rft.aufirst=Heather&rft.date=2015-10-01&rft.volume=30&rft.issue=10&rft.spage=986&rft.isbn=&rft.btitle=&rft.title=Health+Communication&rft.issn=10410236&rft_id=info:doi/10.1080%2F10410236.2014.913221 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-07-20 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1080/10410236.2014.913221 ER - TY - JOUR T1 - Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells. AN - 1718330937; 26419945 AB - Ginkgo biloba leaf extract has been shown to increase the incidence in liver tumors in mice in a 2-year bioassay conducted by the National Toxicology Program. In this study, the DNA damaging effects of Ginkgo biloba leaf extract and many of its constituents were evaluated in human hepatic HepG2 cells and the underlying mechanism was determined. A molecular docking study revealed that quercetin, a flavonoid constituent of Ginkgo biloba, showed a higher potential to interact with topoisomerase II (Topo II) than did the other Ginkgo biloba constituents; this in silico prediction was confirmed by using a biochemical assay to study Topo II enzyme inhibition. Moreover, as measured by the Comet assay and the induction of γ-H2A.X, quercetin, followed by keampferol and isorhamnetin, appeared to be the most potent DNA damage inducer in HepG2 cells. In Topo II knockdown cells, DNA damage triggered by Ginkgo biloba leaf extract or quercetin was dramatically decreased, indicating that DNA damage is directly associated with Topo II. DNA damage was also observed when cells were treated with commercially available Ginkgo biloba extract product. Our findings suggest that Ginkgo biloba leaf extract- and quercetin-induced in vitro genotoxicity may be the result of Topo II inhibition. JF - Scientific reports AU - Zhang, Zhuhong AU - Chen, Si AU - Mei, Hu AU - Xuan, Jiekun AU - Guo, Xiaoqing AU - Couch, Letha AU - Dobrovolsky, Vasily N AU - Guo, Lei AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; College of Bioengineering, Chongqing University, Chongqing 400044, China. Y1 - 2015/09/30/ PY - 2015 DA - 2015 Sep 30 SP - 14633 VL - 5 KW - Mutagens KW - 0 KW - Plant Extracts KW - Topoisomerase II Inhibitors KW - Quercetin KW - 9IKM0I5T1E KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - Index Medicus KW - Gene Silencing KW - Models, Molecular KW - Humans KW - Topoisomerase II Inhibitors -- toxicity KW - Mutagens -- toxicity KW - Mutagens -- pharmacology KW - Topoisomerase II Inhibitors -- chemistry KW - Topoisomerase II Inhibitors -- pharmacology KW - Gene Knockdown Techniques KW - Hep G2 Cells KW - Quercetin -- toxicity KW - Enzyme Activation -- drug effects KW - Molecular Conformation KW - Mutagens -- chemistry KW - Quercetin -- pharmacology KW - Plant Extracts -- pharmacology KW - Hepatocytes -- drug effects KW - DNA Topoisomerases, Type II -- genetics KW - DNA Topoisomerases, Type II -- metabolism KW - Plant Extracts -- toxicity KW - Plant Leaves -- chemistry KW - Hepatocytes -- physiology KW - Plant Extracts -- chemistry KW - Ginkgo biloba -- chemistry KW - DNA Topoisomerases, Type II -- chemistry KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718330937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Ginkgo+biloba+leaf+extract+induces+DNA+damage+by+inhibiting+topoisomerase+II+activity+in+human+hepatic+cells.&rft.au=Zhang%2C+Zhuhong%3BChen%2C+Si%3BMei%2C+Hu%3BXuan%2C+Jiekun%3BGuo%2C+Xiaoqing%3BCouch%2C+Letha%3BDobrovolsky%2C+Vasily+N%3BGuo%2C+Lei%3BMei%2C+Nan&rft.aulast=Zhang&rft.aufirst=Zhuhong&rft.date=2015-09-30&rft.volume=5&rft.issue=&rft.spage=14633&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep14633 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-19 N1 - Date created - 2015-09-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mutat Res. 2010 Feb;696(1):41-7 [20025993] Eur J Clin Pharmacol. 2010 May;66(5):503-9 [20186406] Toxicol Sci. 2010 Aug;116(2):488-97 [20507880] Curr Med Chem. 2012;19(31):5287-93 [22998568] Toxicol In Vitro. 2001 Jun;15(3):245-56 [11377097] Annu Rev Biochem. 2001;70:369-413 [11395412] J Pharm Pharmacol. 2002 May;54(5):661-9 [12005361] Hum Psychopharmacol. 2002 Aug;17(6):267-77 [12404671] Curr Top Med Chem. 2003;3(3):321-38 [12570766] Drugs R D. 2003;4(3):188-93 [12757407] Cancer Cell. 2003 May;3(5):421-9 [12781359] Pharmacol Ther. 2003 Aug;99(2):167-81 [12888111] Mutat Res. 1981 Mar;88(3):317-24 [7254225] Nat Prod Res. 2011 Feb;25(3):222-31 [20544499] Free Radic Biol Med. 2011 Oct 1;51(7):1406-10 [21745563] Toxicol Sci. 2011 Dec;124(2):388-99 [21908763] Nat Rev Mol Cell Biol. 2011 Dec;12(12):827-41 [22108601] Methods Mol Biol. 2012;817:231-50 [22147576] Eur J Clin Pharmacol. 2012 May;68(5):553-60 [22189672] Molecules. 2012;17(5):5255-68 [22565478] Toxicol Sci. 2012 Jun;127(2):582-91 [22387747] Neurology. 2012 Sep 18;79(12):1278-84 [22955125] Environ Mol Mutagen. 1994;24(4):245-61 [7851337] Biochemistry. 1992 Dec 8;31(48):12069-75 [1333791] Lancet Neurol. 2012 Oct;11(10):851-9 [22959217] Mutat Res. 1995 Jun;343(2-3):85-94 [7791812] Cancer Causes Control. 1996 Nov;7(6):581-90 [8932918] J Biol Chem. 1998 Mar 6;273(10):5858-68 [9488723] Mutat Res. 1998 May 25;400(1-2):271-8 [9685677] Biochem J. 2004 Dec 15;384(Pt 3):527-41 [15312049] Pharmacogenetics. 2004 Dec;14(12):841-50 [15608563] Rapid Commun Mass Spectrom. 2006;20(18):2753-60 [16921563] J Clin Pharmacol. 2006 Nov;46(11):1290-8 [17050793] Mutat Res. 2007 Oct 1;623(1-2):83-97 [17681352] Cell Biochem Biophys. 2007;49(1):29-36 [17873337] Food Chem Toxicol. 2007 Dec;45(12):2441-5 [17681658] J Nutr. 2008 Sep;138(9):1615-21 [18716159] Toxicology. 2008 Dec 30;254(3):192-8 [18840496] J Chromatogr A. 2009 Mar 13;1216(11):2002-32 [19195661] Natl Toxicol Program Tech Rep Ser. 2013 Mar;(578):1-183 [23652021] Arch Toxicol. 2013 Jun;87(6):1115-27 [23397584] Toxicol Lett. 2013 Jul 31;221(1):64-72 [23747414] Toxicol Sci. 2014 Feb;137(2):404-15 [24194395] Food Chem Toxicol. 2014 Mar;65:233-41 [24394490] Ann N Y Acad Sci. 2014 Mar;1310:98-110 [24495080] Toxicol Sci. 2014 Jun;139(2):338-49 [24595819] Toxicology. 2014 Aug 1;322:78-88 [24865413] J Biomol Screen. 2014 Oct;19(9):1246-54 [24980598] Int J Geriatr Psychiatry. 2014 Oct;29(10):1087-95 [24633934] Planta Med. 2010 Oct;76(15):1683-90 [20486074] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4790-5 [10758153] Toxicol Lett. 2000 Jul 27;116(1-2):7-16 [10906417] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep14633 ER - TY - JOUR T1 - Estrogenic activity data extraction and in silico prediction show the endocrine disruption potential of bisphenol A replacement compounds. AN - 1715661244; 26308263 AB - Bisphenol A (BPA) replacement compounds are released to the environment and cause widespread human exposure. However, a lack of thorough safety evaluations on the BPA replacement compounds has raised public concerns. We assessed the endocrine disruption potential of BPA replacement compounds in the market to assist their safety evaluations. A literature search was conducted to ascertain the BPA replacement compounds in use. Available experimental estrogenic activity data of these compounds were extracted from the Estrogenic Activity Database (EADB) to assess their estrogenic potential. An in silico model was developed to predict the estrogenic activity of compounds lacking experimental data. Molecular dynamics (MD) simulations were performed to understand the mechanisms by which the estrogenic compounds bind to and activate the estrogen receptor (ER). Forty-five BPA replacement compounds were identified in the literature. Seven were more estrogenic and five less estrogenic than BPA, while six were nonestrogenic in EADB. A two-tier in silico model was developed based on molecular docking to predict the estrogenic activity of the 27 compounds lacking data. Eleven were predicted as ER binders and 16 as nonbinders. MD simulations revealed hydrophobic contacts and hydrogen bonds as the main interactions between ER and the estrogenic compounds. JF - Chemical research in toxicology AU - Ng, Hui Wen AU - Shu, Mao AU - Luo, Heng AU - Ye, Hao AU - Ge, Weigong AU - Perkins, Roger AU - Tong, Weida AU - Hong, Huixiao AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration , 3900 NCTR Road, Jefferson, Arkansas 72079, United States. Y1 - 2015/09/21/ PY - 2015 DA - 2015 Sep 21 SP - 1784 EP - 1795 VL - 28 IS - 9 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Estrogens KW - Phenols KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Computer Simulation KW - Databases, Chemical KW - Molecular Dynamics Simulation KW - Endocrine Disruptors -- toxicity KW - Benzhydryl Compounds -- toxicity KW - Estrogens -- pharmacology KW - Phenols -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1715661244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+industrial+health&rft.atitle=UVA+photoirradiation+of+benzo%5Ba%5Dpyrene+metabolites%3A+induction+of+cytotoxicity%2C+reactive+oxygen+species%2C+and+lipid+peroxidation.&rft.au=Xia%2C+Qingsu%3BChiang%2C+Hsiu-Mei%3BYin%2C+Jun-Jie%3BChen%2C+Shoujun%3BCai%2C+Lining%3BYu%2C+Hongtao%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2015-10-01&rft.volume=31&rft.issue=10&rft.spage=898&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+industrial+health&rft.issn=1477-0393&rft_id=info:doi/10.1177%2F0748233713484648 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-08 N1 - Date created - 2015-09-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00243 ER - TY - JOUR T1 - Alternative testing methods for skin sensitization: NMR spectroscopy for probing the reactivity and classification of potential skin sensitizers. AN - 1715660927; 26225548 AB - Evaluating consumer products for potentially harmful side effects of chemical ingredients is important for the protection of both the consumer and those involved in the manufacturing process. In order to assess the risk potential of chemicals, regulatory agencies have encouraged the development of several in silico, in vitro, and in chemico methods as alternatives to eliminate or minimize the use of animals. To add structural information to the existing in chemico methods, an NMR-based method is proposed for probing the reactivity and classification of the potential electrophiles (E) using a model thiol, DCYA, as a nucleophile. The major advantage of the NMR method is the quantitation of the actual adduct, DCYA-E. The degree of reaction is here provided as a direct measurement of adduct formation and/or electrophile depletion, in contrast to other in chemico assays, e.g., ADRA and DPRA, where the reactivity is inferred from the quantification of the test nucleophile depletion. Moreover, the developed NMR method should serve as a qualitative and quantitative tool in understanding the site of reaction and other structural information associated with test sensitizer. This is particularly valuable and advantageous over methods encouraged by regulatory agencies, which merely provide quantification of the reaction but lack any structural information. Several compounds with multiple reaction sites were successfully tested with the proposed NMR method. Otherwise, these compounds have proven to be a challenge to identify and classify using existing alternative methods. JF - Chemical research in toxicology AU - Chittiboyina, Amar G AU - Avonto, Cristina AU - Rua, Diego AU - Khan, Ikhlas A AD - The Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States. Y1 - 2015/09/21/ PY - 2015 DA - 2015 Sep 21 SP - 1704 EP - 1714 VL - 28 IS - 9 KW - Index Medicus KW - Animals KW - Skin -- drug effects KW - Proton Magnetic Resonance Spectroscopy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1715660927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Alternative+testing+methods+for+skin+sensitization%3A+NMR+spectroscopy+for+probing+the+reactivity+and+classification+of+potential+skin+sensitizers.&rft.au=Chittiboyina%2C+Amar+G%3BAvonto%2C+Cristina%3BRua%2C+Diego%3BKhan%2C+Ikhlas+A&rft.aulast=Chittiboyina&rft.aufirst=Amar&rft.date=2015-09-21&rft.volume=28&rft.issue=9&rft.spage=1704&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Facs.chemrestox.5b00098 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-08 N1 - Date created - 2015-09-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.chemrestox.5b00098 ER - TY - CPAPER T1 - Current US FDA Approaches to the Regulation and Approval of Novel Antibacterial Therapeutics T2 - 2015 Interscience Conference of Antimicrobial Agents and Chemotherapy and International Congress of Chemotherapy and Infection (ICAAC/ICC 2015) AN - 1704507129; 6354893 JF - 2015 Interscience Conference of Antimicrobial Agents and Chemotherapy and International Congress of Chemotherapy and Infection (ICAAC/ICC 2015) AU - Nambiar, Sumathi Y1 - 2015/09/17/ PY - 2015 DA - 2015 Sep 17 KW - FDA KW - Antibiotics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704507129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Interscience+Conference+of+Antimicrobial+Agents+and+Chemotherapy+and+International+Congress+of+Chemotherapy+and+Infection+%28ICAAC%2FICC+2015%29&rft.atitle=Current+US+FDA+Approaches+to+the+Regulation+and+Approval+of+Novel+Antibacterial+Therapeutics&rft.au=Nambiar%2C+Sumathi&rft.aulast=Nambiar&rft.aufirst=Sumathi&rft.date=2015-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Interscience+Conference+of+Antimicrobial+Agents+and+Chemotherapy+and+International+Congress+of+Chemotherapy+and+Infection+%28ICAAC%2FICC+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={7A574A80-EAB1-4B50-B343-4695DF14907E} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-31 N1 - Last updated - 2015-08-18 ER - TY - JOUR T1 - Urogenital Chlamydia trachomatis strain types, defined by high-resolution multilocus sequence typing, in relation to ethnicity and urogenital symptoms among a young screening population in Amsterdam, The Netherlands AN - 1827926997; PQ0003419399 AB - IntroductionPrevious studies found conflicting results regarding associations between urogenital Chlamydia trachomatis infections and ethnicity or urogenital symptoms among at-risk populations using either ompA-based genotyping or high-resolution multilocus sequence typing (MLST). This study applied high-resolution MLST on samples of individuals from a selected young urban screening population to assess the relationship of C. trachomatis strain types with ethnicity and self-reported urogenital symptoms. Demographic and sexual risk behaviour characteristics of the identified clusters were also analysed.MethodsWe selected C. trachomatis-positive samples from the Dutch Chlamydia Screening Implementation study among young individuals in Amsterdam, the Netherlands. All samples were typed using high-resolution MLST. Clusters were assigned using minimum spanning tree analysis and were combined with epidemiological data of the participants.ResultsWe obtained full MLST data for C. trachomatis-positive samples from 439 participants and detected nine ompA genovars. MLST analysis identified 175 sequence types and six large clusters; in one cluster, participants with Surinamese/Antillean ethnicity were over-represented (58.8%) and this cluster predominantly consisted of genovar I. In addition, we found one cluster with an over-representation of participants with Dutch ethnicity (90.0%) and which solely consisted of genovar G. No association was observed between C. trachomatis clusters and urogenital symptoms.ConclusionsWe found an association between urogenital C. trachomatis clusters and ethnicity among young screening participants in Amsterdam, the Netherlands. However, no association was found between C. trachomatis clusters and self-reported urogenital symptoms. JF - Sexually Transmitted Infections AU - Versteeg, Bart AU - Himschoot, Michelle AU - van den Broek, Ingrid V F AU - Bom, Reinier J M AU - Speksnijder, Arjen G C L AU - Schim van der Loeff, Maarten F AU - Bruisten, Sylvia M AD - Public Health Laboratory, Cluster Infectious Diseases, Public Health Service Amsterdam, , Amsterdam, The Netherlands Y1 - 2015/09/16/ PY - 2015 DA - 2015 Sep 16 SP - 415 EP - 422 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 91 IS - 6 SN - 1368-4973, 1368-4973 KW - Microbiology Abstracts B: Bacteriology KW - CHLAMYDIA TRACHOMATIS KW - CHLAMYDIA INFECTION KW - BACTERIAL TYPING KW - Demography KW - Data processing KW - Trees KW - Genotyping KW - Chlamydia trachomatis KW - Infection KW - Sexual behavior KW - Ethnic groups KW - multilocus sequence typing KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827926997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=Urogenital+Chlamydia+trachomatis+strain+types%2C+defined+by+high-resolution+multilocus+sequence+typing%2C+in+relation+to+ethnicity+and+urogenital+symptoms+among+a+young+screening+population+in+Amsterdam%2C+The+Netherlands&rft.au=Versteeg%2C+Bart%3BHimschoot%2C+Michelle%3Bvan+den+Broek%2C+Ingrid+V+F%3BBom%2C+Reinier+J+M%3BSpeksnijder%2C+Arjen+G+C+L%3BSchim+van+der+Loeff%2C+Maarten+F%3BBruisten%2C+Sylvia+M&rft.aulast=Versteeg&rft.aufirst=Bart&rft.date=2015-09-16&rft.volume=91&rft.issue=6&rft.spage=415&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/10.1136%2Fsextrans-2014-051790 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Demography; Data processing; Trees; Genotyping; Infection; Sexual behavior; Ethnic groups; multilocus sequence typing; Chlamydia trachomatis DO - http://dx.doi.org/10.1136/sextrans-2014-051790 ER - TY - JOUR T1 - Nonclinical evaluation of the potential for mast cell activation by an erythropoietin analog. AN - 1706577997; 26079829 AB - The erythropoietin analog peginesatide was withdrawn from marketing due to unexpected severe anaphylactic reactions associated with administration of the multi-use formulation. The adverse events occurred rapidly following the first ever administration of the drug with most affected patients becoming symptomatic in less than 30min. This is most consistent with an anaphylactoid reaction due to direct activation of mast cells. Laboratory evaluation was undertaken using rat peritoneal mast cells as the model system. Initial studies showed that high concentrations of the formulated drug as well as formulated vehicle alone could cause mast cell degranulation as measured by histamine release. The purified active drug was not able to cause histamine release whereas the vehicle filtrate and lab created drug vehicle were equally potent at causing histamine release. Individual formulations of vehicle leaving one component out showed that histamine release was due to phenol. Dose response studies with phenol showed a very sharp dose response curve that was similar in three buffer systems. Cellular analysis by flow cytometry showed that the histamine release was not due to cell death, and that changes in light scatter parameters consistent with degranulation were rapidly observed. Limited testing with primary human mast cells showed a similar dose response of histamine release with exposure to phenol. To provide in vivo confirmation, rats were injected with vehicle formulated with various concentrations of phenol via a jugular vein cannula. Significant release of histamine was detected in blood samples taken 2min after dosing at the highest concentrations tested. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Weaver, James L AU - Boyne, Michael AU - Pang, Eric AU - Chimalakonda, Krishna AU - Howard, Kristina E AD - Division of Applied Regulatory Science, OCP/OTS/CDER/FDA, Silver Spring, MD, USA. Electronic address: James.Weaver@fda.hhs.gov. ; Division of Pharmaceutical Analysis, OTR/OPQ/CDER/FDA, Silver Spring, MD, USA. Electronic address: mboyne@biotechlogic.com. ; Division of Applied Regulatory Science, OCP/OTS/CDER/FDA, Silver Spring, MD, USA. Electronic address: Eric.Pang@fda.hhs.gov. ; Division of Applied Regulatory Science, OCP/OTS/CDER/FDA, Silver Spring, MD, USA. Electronic address: Krishna.Chimalakonda@fda.hhs.gov. ; Division of Applied Regulatory Science, OCP/OTS/CDER/FDA, Silver Spring, MD, USA. Electronic address: Kristina.Howard@fda.hhs.gov. Y1 - 2015/09/15/ PY - 2015 DA - 2015 Sep 15 SP - 246 EP - 252 VL - 287 IS - 3 KW - Excipients KW - 0 KW - Hematinics KW - Peptides KW - peginesatide KW - Phenol KW - 339NCG44TV KW - Histamine KW - 820484N8I3 KW - Index Medicus KW - Mast cells KW - Anaphylactoid KW - Peginesatide KW - Animals KW - Rats, Sprague-Dawley KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Chemistry, Pharmaceutical KW - Cells, Cultured KW - Mice, Inbred NOD KW - Humans KW - Primary Cell Culture KW - Time Factors KW - Female KW - Risk Assessment KW - Hematinics -- toxicity KW - Histamine -- blood KW - Histamine -- metabolism KW - Excipients -- administration & dosage KW - Mast Cells -- drug effects KW - Cell Degranulation -- drug effects KW - Phenol -- toxicity KW - Hematinics -- chemistry KW - Excipients -- toxicity KW - Phenol -- chemistry KW - Mast Cells -- metabolism KW - Phenol -- administration & dosage KW - Excipients -- chemistry KW - Peptides -- chemistry KW - Peptides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1706577997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Nonclinical+evaluation+of+the+potential+for+mast+cell+activation+by+an+erythropoietin+analog.&rft.au=Weaver%2C+James+L%3BBoyne%2C+Michael%3BPang%2C+Eric%3BChimalakonda%2C+Krishna%3BHoward%2C+Kristina+E&rft.aulast=Weaver&rft.aufirst=James&rft.date=2015-09-15&rft.volume=287&rft.issue=3&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.06.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-16 N1 - Date created - 2015-08-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.06.009 ER - TY - JOUR T1 - Creation of a retrospective job-exposure matrix using surrogate measures of exposure for a cohort of US career firefighters from San Francisco, Chicago and Philadelphia AN - 1808704872; PQ0003419056 AB - ObjectivesTo construct a cohort-specific job-exposure matrix (JEM) using surrogate metrics of exposure for a cancer study on career firefighters from the Chicago, Philadelphia and San Francisco Fire Departments.MethodsDepartmental work history records, along with data on historical annual fire-runs and hours, were collected from 1950 to 2009 and coded into separate databases. These data were used to create a JEM based on standardised job titles and fire apparatus assignments using several surrogate exposure metrics to estimate firefighters' exposure to the combustion byproducts of fire. The metrics included duration of exposure (cumulative time with a standardised exposed job title and assignment), fire-runs (cumulative events of potential fire exposure) and time at fire (cumulative hours of potential fire exposure).ResultsThe JEM consisted of 2298 unique job titles alongside 16174 fire apparatus assignments from the three departments, which were collapsed into 15 standardised job titles and 15 standardised job assignments. Correlations were found between fire-runs and time at fires (Pearson coefficient=0.92), duration of exposure and time at fires (Pearson coefficient=0.85), and duration of exposure and fire-runs (Pearson coefficient=0.82). Total misclassification rates were found to be between 16-30% when using duration of employment as an exposure surrogate, which has been traditionally used in most epidemiological studies, compared with using the duration of exposure surrogate metric.ConclusionsThe constructed JEM successfully differentiated firefighters based on gradient levels of potential exposure to the combustion byproducts of fire using multiple surrogate exposure metrics. JF - Occupational and Environmental Medicine AU - Dahm, Matthew M AU - Bertke, Stephen AU - Allee, Steve AU - Daniels, Robert D AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/09/10/ PY - 2015 DA - 2015 Sep 10 SP - 670 EP - 677 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 72 IS - 9 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Firefighters KW - Job-Exposure Matrix KW - Dose-Response KW - USA, Illinois, Chicago KW - Historical account KW - Fires KW - Data processing KW - USA, Pennsylvania, Philadelphia KW - Byproducts KW - Careers KW - Employment KW - Cancer KW - Combustion KW - Databases KW - Firefighter services KW - INE, USA, California, San Francisco KW - Data bases KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808704872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Creation+of+a+retrospective+job-exposure+matrix+using+surrogate+measures+of+exposure+for+a+cohort+of+US+career+firefighters+from+San+Francisco%2C+Chicago+and+Philadelphia&rft.au=Dahm%2C+Matthew+M%3BBertke%2C+Stephen%3BAllee%2C+Steve%3BDaniels%2C+Robert+D&rft.aulast=Dahm&rft.aufirst=Matthew&rft.date=2015-09-10&rft.volume=72&rft.issue=9&rft.spage=670&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102790 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Databases; Fires; Data processing; Cancer; Combustion; Historical account; Byproducts; Firefighter services; Careers; Employment; Data bases; USA, Illinois, Chicago; USA, Pennsylvania, Philadelphia; INE, USA, California, San Francisco DO - http://dx.doi.org/10.1136/oemed-2014-102790 ER - TY - JOUR T1 - Platinum Nanoparticles: Efficient and Stable Catechol Oxidase Mimetics. AN - 1710983868; 26305170 AB - Although enzyme-like nanomaterials have been extensively investigated over the past decade, most research has focused on the peroxidase-like, catalase-like, or SOD-like activity of these nanomaterials. Identifying nanomaterials having oxidase-like activities has received less attention. In this study, we demonstrate that platinum nanoparticles (Pt NPs) exhibit catechol oxidase-like activity, oxidizing polyphenols into the corresponding o-quinones. Four unique approaches are employed to demonstrate the catechol oxidase-like activity exerted by Pt NPs. First, UV-vis spectroscopy is used to monitor the oxidation of polyphenols catalyzed by Pt NPs. Second, the oxidized products of polyphenols are identified by ultrahigh-performance liquid chromatography (UHPLC) separation followed by high-resolution mass spectrometry (HRMS) identification. Third, electron spin resonance (ESR) oximetry techniques are used to confirm the O2 consumption during the oxidation reaction. Fourth, the intermediate products of semiquinone radicals formed during the oxidation of polyphenols are determined by ESR using spin stabilization. These results indicate Pt NPs possess catechol oxidase-like activity. Because polyphenols and related bioactive substances have been explored as potent antioxidants that could be useful for the prevention of cancer and cardiovascular diseases, and Pt NPs have been widely used in the chemical industry and medical science, it is essential to understand the potential effects of Pt NPs for altering or influencing the antioxidant activity of polyphenols. JF - ACS applied materials & interfaces AU - Liu, Yi AU - Wu, Haohao AU - Chong, Yu AU - Wamer, Wayne G AU - Xia, Qingsu AU - Cai, Lining AU - Nie, Zhihong AU - Fu, Peter P AU - Yin, Jun-Jie AD - Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , College Park, Maryland 20740, United States. ; Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , College Park, Maryland 20740, United States. ; Biochemical Toxicology Division, National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson, Arkansas 72079, United States. ; Biotranex LLC , Monmouth Junction, New Jersey 08852, United States. ; Department of Chemistry and Biochemistry, University of Maryland , College Park, Maryland 20742, United States. Y1 - 2015/09/09/ PY - 2015 DA - 2015 Sep 09 SP - 19709 EP - 19717 VL - 7 IS - 35 KW - Caffeic Acids KW - 0 KW - Polyphenols KW - Quinones KW - Platinum KW - 49DFR088MY KW - Catechin KW - 8R1V1STN48 KW - Quercetin KW - 9IKM0I5T1E KW - Catechol Oxidase KW - EC 1.10.3.1 KW - Monophenol Monooxygenase KW - EC 1.14.18.1 KW - Oxygen KW - S88TT14065 KW - caffeic acid KW - U2S3A33KVM KW - Index Medicus KW - oxidation of polyphenols KW - enzyme mimetics KW - platinum nanoparticles KW - catechol oxidase-like activity KW - heterogeneous catalysts KW - Caffeic Acids -- chemistry KW - Mass Spectrometry KW - Monophenol Monooxygenase -- metabolism KW - Quinones -- chemistry KW - Catechol Oxidase -- chemistry KW - Quinones -- analysis KW - Monophenol Monooxygenase -- chemistry KW - Quercetin -- chemistry KW - Catechol Oxidase -- metabolism KW - Catechin -- chemistry KW - Chromatography, High Pressure Liquid KW - Oxidation-Reduction KW - Electron Spin Resonance Spectroscopy KW - Oxygen -- chemistry KW - Polyphenols -- analysis KW - Polyphenols -- chemistry KW - Catalysis KW - Platinum -- chemistry KW - Metal Nanoparticles -- chemistry KW - Biomimetic Materials -- metabolism KW - Biomimetic Materials -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1710983868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+applied+materials+%26+interfaces&rft.atitle=Platinum+Nanoparticles%3A+Efficient+and+Stable+Catechol+Oxidase+Mimetics.&rft.au=Bui-Nguyen%2C+Tri+M%3BBaer%2C+Christine+E%3BLewis%2C+John+A%3BYang%2C+Dongren%3BLein%2C+Pamela+J%3BJackson%2C+David+A&rft.aulast=Bui-Nguyen&rft.aufirst=Tri&rft.date=2015-10-24&rft.volume=16&rft.issue=&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2Fs12864-015-1941-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-13 N1 - Date created - 2015-09-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acsami.5b05180 ER - TY - JOUR T1 - Deciphering the underlying mechanisms of oxidation-state dependent cytotoxicity of graphene oxide on mammalian cells. AN - 1693711121; 26047786 AB - The promising broad applications of graphene oxide (GO) derivatives in biomedicine have raised concerns about their safety on biological organisms. However, correlations between the physicochemical properties, especially oxidation degree of GOs and their toxicity, and the underlying mechanisms are not well understood. Herein, we evaluated the cytotoxicity of three GO samples with various oxidation degrees on mouse embryo fibroblasts (MEFs). Three samples can be internalized by MEFs observed via transmission electron microscopy (TEM), and were well tolerant by MEFs at lower doses (below 25μg/ml) but significantly toxic at 50 and 100μg/ml via Cytell Imaging System. More importantly, as the oxidation degree decreased, GO derivatives led to a higher degree of cytotoxicity and apoptosis. Meanwhile, three GOs stimulated dramatic enhancement in reactive oxygen species (ROS) production in MEFs, where the less oxidized GO produced a higher level of ROS, suggesting the major role of oxidative stress in the oxidation-degree dependent toxicity of GOs. Results from electron spin resonance (ESR) spectrometry showed a strong association of the lower oxidation degree of GOs with their stronger indirect oxidative damage through facilitating H2O2 decomposition into OH and higher direct oxidative abilities on cells. The theoretical simulation revealed the key contributions of carboxyl groups and aromatic domain size of nanosheets to varying the energy barrier of H2O2 decomposition reaction. These systematic explorations in the chemical mechanisms unravel the key physicochemical properties that would lead to the diverse toxic profiles of the GO nanosheets with different oxygenation levels, and offer us new clues in the molecular design of carbon nanomaterials for their safe applications in biomedicine. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Zhang, Wendi AU - Yan, Liang AU - Li, Meng AU - Zhao, Ruisheng AU - Yang, Xiao AU - Ji, Tianjiao AU - Gu, Zhanjun AU - Yin, Jun-Jie AU - Gao, Xingfa AU - Nie, Guangjun AD - Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. ; Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China. ; Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. ; Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China. Electronic address: niegj@nanoctr.cn. Y1 - 2015/09/02/ PY - 2015 DA - 2015 Sep 02 SP - 61 EP - 71 VL - 237 IS - 2 KW - Oxides KW - 0 KW - Reactive Oxygen Species KW - Graphite KW - 7782-42-5 KW - Index Medicus KW - Cytotoxicity KW - Reactive oxygen species (ROS) KW - Apoptosis KW - Graphene oxide (GO) KW - Electron spin resonance (ESR) spectrometry KW - Oxidation-Reduction KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Electron Spin Resonance Spectroscopy KW - Apoptosis -- drug effects KW - Oxides -- pharmacology KW - Mice KW - Graphite -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1693711121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Deciphering+the+underlying+mechanisms+of+oxidation-state+dependent+cytotoxicity+of+graphene+oxide+on+mammalian+cells.&rft.au=Zhang%2C+Wendi%3BYan%2C+Liang%3BLi%2C+Meng%3BZhao%2C+Ruisheng%3BYang%2C+Xiao%3BJi%2C+Tianjiao%3BGu%2C+Zhanjun%3BYin%2C+Jun-Jie%3BGao%2C+Xingfa%3BNie%2C+Guangjun&rft.aulast=Zhang&rft.aufirst=Wendi&rft.date=2015-09-02&rft.volume=237&rft.issue=2&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2015.05.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-15 N1 - Date created - 2015-07-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2015.05.021 ER - TY - RPRT T1 - Which Early Care and Education Centers Participate in Head Start or Public Pre-Kindergarten? National Survey of Early Care & Education. Technical Report. OPRE Report 2015-92a AN - 1826518484; ED564119 AB - This report draws on newly available data from the National Survey of Early Care and Education (NSECE) to describe early care and education (ECE) centers that participate in two prominent publicly-funded ECE initiatives: Head Start and publicly-funded pre-kindergarten. Although a great deal is known about Head Start programs, and there are sources of information about Public Pre-K, there has been no available data source that documents how centers participating in these publicly-funded initiatives fit within the full spectrum of center-based ECE. This report identifies the number of centers nationally that had enrollment funded by Head Start or Public Pre-K funds in 2012, and describes some characteristics of these programs. In the NSECE data, a "center" refers to all ECE services to children under age 13 years provided by one organization in a single location. An accompanying technical supplement provides details on the methodology for identifying programs as participating in these two ECE initiatives, and explains some issues pertaining to analyses of NSECE data regarding programs' participation in Head Start and Public Pre-K. [For "Identifying Head Start and Public Pre-K Participation in NSECE Data on Center-Based ECE Programs. NSECE Technical Report Supplement. OPRE Report 2015-92b," see ED564118.] Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 8 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Financial Support KW - Geographic Location KW - Institutional Characteristics KW - Educational Finance KW - National Surveys KW - Public Schools KW - Enrollment KW - Early Intervention KW - Poverty Areas KW - Child Care Centers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826518484?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Identifying Head Start and Public Pre-K Participation in NSECE Data on Center-Based ECE Programs. NSECE Technical Report Supplement. OPRE Report 2015-92b AN - 1826516946; ED564118 AB - The analyses presented in the Technical Report, "Which Centers Participate in Head Start or Public Pre-Kindergarten" characterize centers that have at least one child whose enrollment is funded through Head Start or Public Pre-K funds. This supplement to the technical report provides interested readers with technical details of the analyses, including additional information about tabulations and definitions used, as well as discussion of features of the data that affect how additional analyses might be undertaken. [For "Which Early Care and Education Centers Participate in Head Start or Public Pre-Kindergarten? National Survey of Early Care & Education. Technical Report. OPRE Report 2015-92a," see ED564119.] AU - Goerge, Robert AU - Datta, Rupa A. AU - Xia, Kanru AU - Witte, Ann D. AU - Gennetian, Lisa A. AU - Milesi, Carolina AU - Brandon, Richard AU - Guzman, Lina AU - Zanoni, Wladimir Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 8 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Preschool Education KW - Financial Support KW - Geographic Location KW - Institutional Characteristics KW - Public Schools KW - Research Methodology KW - Educational Finance KW - Enrollment KW - Early Intervention KW - Child Care Centers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826516946?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Hemoglobin assay for validation and quality control of medical device reprocessing AN - 1746891975; PQ0001974740 AB - Hemoglobin (Hb) is an important analyte in medicine, forensics, and research. One area of crucial need for real-world Hb quantitation is the validation and quality control (QC) of reprocessed medical device cleaning. Here, we show how a microplate reader and colorimetric blood test strips can be used to quantitate nanogram (ng) quantities of Hb in a 1-min assay. The assay had a linear range of 0-50 ng (0-370 ng on a log scale) for Hb, with a limit of detection (LOD) of 3.3 ng, which was 500-fold more sensitive than the micro-BCA reagent (LOD=1.6 mu g) and on the same order of magnitude as detection of labeled Hb with fluorescence (LOD=1.9 ng). For validation of medical device cleaning, the assay was specific for Hb in the presence of artificial test soil and was unaffected by interferences from common cleaning reagents at 10 ppm. Lubricant and sodium dodecyl sulfate did not significantly affect the assay at 10 ppm but affected the assay at 1 % g/g. The method showed 100 % recovery of hemoglobin in extracted soils, with extraction from silicone having the greatest variability in recovery, while Teflon and stainless steel had <10 % RSD. The assay makes it possible for medical device companies and health-care providers to obtain crucially needed information on the cleanliness of reused devices. JF - Analytical and Bioanalytical Chemistry AU - Frey, Justin AU - Guan, Allan AU - Li, Zhenyu AU - Turtil, Steven AU - Phillips, KScott AD - Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry and Materials Science, United States Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20993, USA, kenneth.phillips@fda.hhs.gov PY - 2015 SP - 6885 EP - 6889 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 407 IS - 22 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Testing Procedures KW - Reagents KW - Variability KW - Fluorescence KW - Cleaning KW - Sodium KW - Blood KW - Assay KW - Quality Control KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746891975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Hemoglobin+assay+for+validation+and+quality+control+of+medical+device+reprocessing&rft.au=Frey%2C+Justin%3BGuan%2C+Allan%3BLi%2C+Zhenyu%3BTurtil%2C+Steven%3BPhillips%2C+KScott&rft.aulast=Frey&rft.aufirst=Justin&rft.date=2015-09-01&rft.volume=407&rft.issue=22&rft.spage=6885&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-015-8856-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 16 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Sodium; Testing Procedures; Blood; Reagents; Variability; Fluorescence; Assay; Quality Control; Cleaning DO - http://dx.doi.org/10.1007/s00216-015-8856-2 ER - TY - JOUR T1 - Development and validation of a new transgenic hairless albino mouse as a mutational model for potential assessment of photocarcinogenicity AN - 1746883167; PQ0002319261 AB - Short-term phototoxicity testing is useful in selecting test agents for the longer and more expensive photocarcinogenesis safety tests; however, no validated short-term tests have been proven reliable in predicting the outcome of a photocarcinogenesis safety test. A transgenic, hairless, albino (THA) mouse model was developed that carries the gpt and red/gam [Spi-] genes from the gpt delta mouse background and the phenotypes from the SKH-1 mouse background to use as a short-term test in lieu of photocarcinogenesis safety tests. Validation of the THA mouse model was confirmed by exposing groups of male mice to sub-erythemal doses of ultraviolet B (UVB) irradiation for three consecutive days emitted from calibrated overhead, Kodacel-filtered fluorescent lamps and measuring the mutant frequencies (MFs) in the gpt and red/gam (Spi-) genes and types of mutations in the gpt gene. The doses or irradiation were monitored with broad-spectrum dosimeters that were calibrated to a NIST-traceable standard and cumulative CIE-weighted doses were 20.55 and 41.0mJ/cm2 (effective). Mice were sacrificed 14 days after the final UVB exposure and MFs in both the gpt and red/gam genes were evaluated in the epidermis. The exposure of mice to UVB induced significant ten- to twelve-fold increases in the gpt MF and three- to five-fold increases in the Spi- MF over their respective background MF, 26 plus or minus 310-6 and 9 plus or minus 110-6. The gpt mutation spectra were significantly different between that of the UVB-irradiated and that of non-irradiated mice although the mutation spectra of both groups were dominated by C arrow right T transitions (84% and 66%). In mice exposed to UVB, the C arrow right T transitions occurred almost exclusively at dipyrimidine sites (92%), whereas in non-irradiated control mice, the C arrow right T transitions occurred at CpG sites (86%). These results suggest that the newly developed THA mice are a useful and reliable model for testing UVB-induced mutagenicity in skin tissue. The application of this model for short-term prediction of solar-induced skin carcinogenicity is presently under investigation. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Manjanatha, Mugimane G AU - Shelton, Sharon D AU - Chen, Ying AU - Gaddameedhi, Shobhan AU - Howard, Paul C AU - Boudreau, Mary D AD - National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, USFDA, Jefferson, AR, United States Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 42 EP - 52 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 791 SN - 1383-5718, 1383-5718 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Toxicology Abstracts KW - Transgenic Hairless albino mouse KW - gpt-Delta mouse KW - Spi- selection assay KW - Mutant frequency KW - Mutation frequency KW - Mutagenicity KW - Skin KW - Animal models KW - CpG islands KW - Mutagenesis KW - Phototoxicity KW - Epidermis KW - beta Radiation KW - U.V. radiation KW - Carcinogenicity KW - Hairless KW - Mutation KW - X 24390:Radioactive Materials KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746883167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Development+and+validation+of+a+new+transgenic+hairless+albino+mouse+as+a+mutational+model+for+potential+assessment+of+photocarcinogenicity&rft.au=Manjanatha%2C+Mugimane+G%3BShelton%2C+Sharon+D%3BChen%2C+Ying%3BGaddameedhi%2C+Shobhan%3BHoward%2C+Paul+C%3BBoudreau%2C+Mary+D&rft.aulast=Manjanatha&rft.aufirst=Mugimane&rft.date=2015-09-01&rft.volume=791&rft.issue=&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2015.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Mutagenicity; Skin; Animal models; Mutant frequency; CpG islands; Mutagenesis; Phototoxicity; Epidermis; beta Radiation; U.V. radiation; Carcinogenicity; Hairless; Mutation DO - http://dx.doi.org/10.1016/j.mrgentox.2015.08.001 ER - TY - JOUR T1 - Potential explosion hazard of carbonaceous nanoparticles: Explosion parameters of selected materials AN - 1732827379; PQ0002231321 AB - Following a previous explosion screening study, we have conducted concentration and ignition energy scans on several carbonaceous nanopowders: fullerene, SWCNT, carbon black, MWCNT, graphene, CNF, and graphite. We have measured minimum explosive concentration (MEC), minimum ignition energy (MIE), and minimum ignition temperature (MITcloud) for these materials. The nanocarbons exhibit MEC ~101-102 g/m3, comparable to the MEC for coals and for fine particle carbon blacks and graphites. The nanocarbons are confirmed mainly to be in the St-1 explosion class, with fullerene, at K St ~200bar-m/s, borderline St-1/St-2. We estimate MIE~102-103 J, an order of magnitude higher than the MIE for coals but an order of magnitude lower than the MIE for fine particle graphites. While the explosion severity of the nanocarbons is comparable to that of the coals, their explosion susceptibility (ease of ignition) is significantly less (i.e., the nanocarbons have higher MIEs than do the coals); by contrast, the nanocarbons exhibit similar explosion severity to the graphites but enhanced explosion susceptibility (i.e., the nanocarbons have lower MIEs than do the graphites). MITcloud >550 degree C, comparable to that of the coals and carbon blacks. JF - Journal of Hazardous Materials AU - Turkevich, Leonid A AU - Dastidar, Ashok G AU - Hachmeister, Zachary AU - Lim, Michael AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, 1090 Tusculum Avenue, MS-R7, Cincinnati, OH 45226, USA Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 97 EP - 103 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 295 SN - 0304-3894, 0304-3894 KW - Toxicology Abstracts; Environment Abstracts KW - Explosion hazard KW - Dust KW - Carbon KW - Nanoparticle KW - Nanomaterials KW - Temperature effects KW - Black carbon KW - Graphite KW - Temperature KW - Particulates KW - Coal KW - Explosions KW - Hazards KW - Fullerenes KW - Energy KW - Explosives KW - nanoparticles KW - X 24350:Industrial Chemicals KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732827379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Hazardous+Materials&rft.atitle=Potential+explosion+hazard+of+carbonaceous+nanoparticles%3A+Explosion+parameters+of+selected+materials&rft.au=Turkevich%2C+Leonid+A%3BDastidar%2C+Ashok+G%3BHachmeister%2C+Zachary%3BLim%2C+Michael&rft.aulast=Turkevich&rft.aufirst=Leonid&rft.date=2015-09-01&rft.volume=295&rft.issue=&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Journal+of+Hazardous+Materials&rft.issn=03043894&rft_id=info:doi/10.1016%2Fj.jhazmat.2015.03.069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Temperature effects; Carbon; Graphite; Fullerenes; Energy; Explosives; Coal; nanoparticles; Hazards; Black carbon; Temperature; Particulates; Explosions DO - http://dx.doi.org/10.1016/j.jhazmat.2015.03.069 ER - TY - JOUR T1 - Job strain and changes in the body mass index among working women: a prospective study AN - 1732813188; PQ0002109948 AB - Objective: The relationship between job strain and weight gain has been unclear, especially for women. Using data from over 52 000 working women, we compare the association between change in job strain and change in body mass index (BMI) across different levels of baseline BMI.Subjects/ Methods: We used data from participants in the Nurses' Health Study II (n=52 656, mean age=38.4 years), an ongoing prospective cohort study. Using linear regression, we modeled the change in BMI over 4 years as a function of the change in job strain, baseline BMI and the interaction between the two. Change in job strain was characterized in four categories combining baseline and follow-up levels as follows: consistently low strain (low at both points), decreased strain (high strain at baseline only), increased strain (high strain at follow-up only) and consistently high strain (high at both points). Age, race/ethnicity, pregnancy history, job types and health behaviors at baseline were controlled for in the model. Results: In adjusted models, women who reported high job strain at least once during the 4-year period had a greater increase in BMI ( Delta BMI=0.06-0.12, P<0.05) compared with those who never reported high job strain. The association between the change in job strain exposure and the change in BMI depended on the baseline BMI level (P=0.015 for the interaction): the greater the baseline BMI, the greater the BMI gain associated with consistently high job strain. The BMI gain associated with increased or decreased job strain was uniform across the range of baseline BMI. Conclusions: Women with higher BMI may be more vulnerable to BMI gain when exposed to constant work stress. Future research focusing on mediating mechanisms between job strain and BMI change should explore the possibility of differential responses to job strain by initial BMI. JF - International Journal of Obesity AU - Fujishiro, K AU - Lawson, C C AU - Hibert, E L AU - Chavarro, J E AU - Rich-Edwards, J W AD - Division of Surveillance, Hazard Evaluation, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, OH, USA PY - 2015 SP - 1395 EP - 1400 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 39 IS - 9 SN - 0307-0565, 0307-0565 KW - Physical Education Index; Health & Safety Science Abstracts KW - Historical account KW - Obesity KW - Age KW - Body mass KW - Women KW - Stress KW - Health KW - Strains KW - Medical personnel KW - Pregnancy KW - Apparel KW - Behavior KW - Body weight KW - Weight KW - Nursing KW - Females KW - Vulnerability KW - Ethnic groups KW - Occupational health KW - H 1000:Occupational Safety and Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732813188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Job+strain+and+changes+in+the+body+mass+index+among+working+women%3A+a+prospective+study&rft.au=Fujishiro%2C+K%3BLawson%2C+C+C%3BHibert%2C+E+L%3BChavarro%2C+J+E%3BRich-Edwards%2C+J+W&rft.aulast=Fujishiro&rft.aufirst=K&rft.date=2015-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Obesity; Weight; Body mass; Women; Stress; Health; Strains; Apparel; Historical account; Age; Medical personnel; Pregnancy; Body weight; Behavior; Nursing; Vulnerability; Females; Ethnic groups; Occupational health DO - http://dx.doi.org/10.1038/ijo.2015.91 ER - TY - JOUR T1 - Colonisation of dentures by Staphylococcus aureus and MRSA in out-patient and in-patient populations AN - 1722181398; PQ0001974677 AB - Methicillin-resistant Staphylococcus aureus (MRSA) is an important human pathogen, and colonisation with this organism can result in localised or systemic infections which may be fatal. One hundred in-patients admitted to a London teaching hospital and 100 out-patients attending prosthetic dentistry clinics were recruited into this study. Of the 100 out-patients, 27 % harboured S. aureus on their dentures, compared to 33 % of in-patients. Only one out-patient had MRSA colonising their dentures whereas 12 % of the in-patients harboured MRSA. The median total bacterial count of the denture plaque samples was 6.210 super(7) cfu/sample and 6.910 super(7) cfu/sample for the out-patient and in-patient populations, respectively. In most instances, where present, S. aureus comprised less than 1 % of the total viable denture microbiota. Phage typing demonstrated that EMRSA-15 and non-typeable strains were harboured on dentures. The results of this study have revealed that dentures are a potential reservoir of MRSA and so account should be taken of these findings when planning decontamination procedures for elimination of this pathogen. JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Lewis, N AU - Parmar, N AU - Hussain, Z AU - Baker, G AU - Green, I AU - Howlett, J AU - Kearns, A AU - Cookson, B AU - McDonald, A AU - Wilson, M AU - Ready, D AD - Eastman Dental Hospital, UCLH NHS Foundation Trust, 256 Gray's Inn Road, London, WC1X 8LD, UK, derren.ready@phe.gov.uk Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 1823 EP - 1826 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 34 IS - 9 SN - 0934-9723, 0934-9723 KW - Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - Dentures KW - Disseminated infection KW - Decontamination KW - Pathogens KW - Dentistry KW - Phage typing KW - Colony-forming cells KW - Plaques KW - Staphylococcus aureus KW - Hospitals KW - Prosthetics KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722181398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=Colonisation+of+dentures+by+Staphylococcus+aureus+and+MRSA+in+out-patient+and+in-patient+populations&rft.au=Lewis%2C+N%3BParmar%2C+N%3BHussain%2C+Z%3BBaker%2C+G%3BGreen%2C+I%3BHowlett%2C+J%3BKearns%2C+A%3BCookson%2C+B%3BMcDonald%2C+A%3BWilson%2C+M%3BReady%2C+D&rft.aulast=Lewis&rft.aufirst=N&rft.date=2015-09-01&rft.volume=34&rft.issue=9&rft.spage=1823&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-015-2418-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 13 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Phage typing; Colony-forming cells; Drug resistance; Disseminated infection; Dentures; Decontamination; Plaques; Dentistry; Pathogens; Prosthetics; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1007/s10096-015-2418-6 ER - TY - JOUR T1 - On the outskirts of national health reform: a comparative assessment of health insurance and access to care in Puerto Rico and the United States AN - 1721357986; 4712142 AB - Policy Points:Puerto Rico is the United States' largest territory, home to nearly 4 million American citizens, yet it has remained largely on the outskirts of US health policy, including the Affordable Care Act (ACA).We analyzed national survey data from 2011 to 2012 and found that despite its far poorer population, Puerto Rico outperforms the mainland United States on several measures of health care coverage and access to care.While the ACA significantly increases federal resources in Puerto Rico, ongoing federal restrictions on Medicaid funding and premium tax credits in Puerto Rico pose substantial health policy challenges in the territory. Puerto Rico is the United States' largest territory, home to nearly 4 million American citizens. Yet it has remained largely on the outskirts of US health policy, including the Affordable Care Act (ACA). This article presents an overview of Puerto Rico's health care system and a comparative analysis of coverage and access to care in Puerto Rico and the mainland United States. We analyzed 2011-2012 data from the Behavioral Risk Factor Surveillance System, and 2012 data from the American Community Survey and its counterpart, the Puerto Rico Community Survey. Among adults 18 and older, we examined health insurance coverage; access measures, such as having a usual source of care and cost-related delays in care; self-reported health; and the receipt of recommended preventive services, such as cancer screening and glucose testing. We used multivariate regression models to compare Puerto Rico and the mainland United States, adjusted for age, income, race/ethnicity, and other demographic variables. Uninsured rates were significantly lower in Puerto Rico (unadjusted 7.4% versus 15.0%, adjusted difference: −12.0%, p < 0.001). Medicaid was far more common in Puerto Rico. Puerto Rican residents were more likely than those in the mainland United States to have a usual source of care and to have had a checkup within the past year, and fewer experienced cost-related delays in care. Screening rates for diabetes, mammograms, and Pap smears were comparable or better in Puerto Rico, while colonoscopy rates were lower. Self-reported health was slightly worse, but obesity and smoking rates were lower. Despite its far poorer population, Puerto Rico outperforms the mainland United States on several measures of coverage and access. Congressional policies capping federal Medicaid funds to the territory, however, have contributed to major budgetary challenges. While the ACA has significantly increased federal resources in Puerto Rico, ongoing restrictions on Medicaid funding and premium tax credits are posing substantial health policy challenges in the territory. Reprinted by permission of Blackwell Publishers JF - Milbank quarterly AU - Portela, Maria AU - Sommers, Benjamin D AD - Harvard University ; US Department of Health and Human Services Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 584 EP - 608 VL - 93 IS - 3 SN - 0887-378X, 0887-378X KW - Political Science KW - Puerto Rico KW - Health care KW - Regression analysis KW - Health insurance KW - Health policy KW - U.S.A. KW - Health services KW - Tax credits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1721357986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Milbank+quarterly&rft.atitle=On+the+outskirts+of+national+health+reform%3A+a+comparative+assessment+of+health+insurance+and+access+to+care+in+Puerto+Rico+and+the+United+States&rft.au=Portela%2C+Maria%3BSommers%2C+Benjamin+D&rft.aulast=Portela&rft.aufirst=Maria&rft.date=2015-09-01&rft.volume=93&rft.issue=3&rft.spage=584&rft.isbn=&rft.btitle=&rft.title=Milbank+quarterly&rft.issn=0887378X&rft_id=info:doi/10.1111%2F1468-0009.12138 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-10-12 N1 - Last updated - 2015-10-12 N1 - SubjectsTermNotLitGenreText - 5784 6592 4957 11923 11949 13521; 12537 2992; 5788 11888 10472; 10739 12228 10919; 5775 13521; 5792 10484; 337 77 14; 433 293 14 DO - http://dx.doi.org/10.1111/1468-0009.12138 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF CIMSTAR 3800 IN F344/NTac RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF CIMSTAR 3800 IN WISTAR HAN [Crl:WI (Han)] RATS AND B6C3F1/N MICE (INHALATION STUDIES) AN - 1719237987 AB - CIMSTAR 3800 is a metalworking fluid used as a lubricant and for cooling during the machining and grinding of aluminum and steel. Exposure to CIMSTAR 3800 vapors occurs in a variety of metalworking occupations. We exposed groups of 50 male and female rats and mice to atmospheres containing aerosols of 10, 30, or 100 mg of CIMSTAR 3800 per cubic meter of air. Similar groups of animals exposed to clean air in the same type of inhalation chambers served as the control groups. Animals were exposed six hours per day, five days per week for two years. Tissues from more than 40 sites were examined for every animal. All groups of male and female rats and mice exposed to CIMSTAR 3800 had increased incidences of lesions of the respiratory tract, including metaplasia of the larynx and hyperplasia of the lung in male and female rats and mice, hyperplasia of tissues of the nose in male and females rats, and metaplasia of tissues of the nose in male and female mice. There were increased incidences of tumors of the thyroid gland and lung in female mice and marginally increased incidences of tumors of the prostate gland in male rats and of tumors of the skin and uterus in female rats. We conclude that exposure to aerosols of CIMSTAR 3800 caused tumors of the thyroid gland and lung in female mice and may have been associated with tumors of the prostate gland in male rats and of the skin and uterus in female rats. A spectrum of nonneoplastic lesions in the respiratory tract (nose, larynx, and lung) of male and female rats and mice were caused by CIMSTAR 3800. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 0_1,0_2,6 EP - 17,19-87,89-131,133-145,147-172 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Toxicology KW - Rodents KW - Metalworking industry KW - Human exposure KW - Tumors KW - Lubricants & lubrication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1719237987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+CIMSTAR+3800+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+CIMSTAR+3800+IN+WISTAR+HAN+%5BCrl%3AWI+%28Han%29%5D+RATS+AND+B6C3F1%2FN+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-09-01&rft.volume=&rft.issue=586&rft.spage=0_1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2015 N1 - Document feature - Tables; Graphs; Illustrations; References N1 - Last updated - 2015-10-06 ER - TY - RPRT T1 - Table of contents AN - 1719237823 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1719237823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-09-01&rft.volume=&rft.issue=586&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2015 N1 - Last updated - 2015-10-06 ER - TY - JOUR T1 - Nonclinical aspects of venous thrombosis in pregnancy. AN - 1718077620; 26404176 AB - Pregnancy is a hypercoagulable state which carries an excess risk of maternal venous thrombosis. Endothelial injury, alterations in blood flow and activation of the coagulation pathway are proposed to contribute to the hypercoagulability. The risk for thrombosis may be accentuated by certain drugs and device implants that directly or indirectly affect the coagulation pathway. To help ensure that these interventions do not result in adverse maternal or fetal outcomes during pregnancy, gravid experimental animals can be exposed to such treatments at various stages of gestation and over a dosage range that would identify hazards and inform risk assessment. Circulating soluble biomarkers can also be evaluated for enhancing the assessment of any increased risk of venous thrombosis during pregnancy. In addition to traditional in vivo animal testing, efforts are under way to incorporate reliable non-animal methods in the assessment of embryofetal toxicity and thrombogenic effects. This review summarizes hemostatic balance during pregnancy in animal species, embryofetal development, biomarkers of venous thrombosis, and alterations caused by drug-induced venous thrombosis. © 2015 Wiley Periodicals, Inc. JF - Birth defects research. Part C, Embryo today : reviews AU - Struble, Evi AU - Harrouk, Wafa AU - DeFelice, Albert AU - Tesfamariam, Belay AD - Division of Hematology Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. ; Division of Nonprescription Drug Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. ; Division of Cardiovascular and Renal Products, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 190 EP - 200 VL - 105 IS - 3 KW - Biomarkers KW - 0 KW - Index Medicus KW - nonclinical evaluation KW - pregnancy KW - embryofetal toxicity assessment KW - drugs/biologics KW - venous thrombosis KW - biomarkers KW - Embryonic Development KW - Venous Thrombosis -- blood KW - Blood Coagulation KW - Animals KW - Venous Thrombosis -- physiopathology KW - Humans KW - Hemostasis KW - Fetal Development KW - Biomarkers -- blood KW - Female KW - Pregnancy KW - Pregnancy Complications, Hematologic -- blood KW - Thrombosis -- blood KW - Pregnancy Complications, Hematologic -- physiopathology KW - Thrombosis -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718077620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.atitle=Nonclinical+aspects+of+venous+thrombosis+in+pregnancy.&rft.au=Struble%2C+Evi%3BHarrouk%2C+Wafa%3BDeFelice%2C+Albert%3BTesfamariam%2C+Belay&rft.aulast=Struble&rft.aufirst=Evi&rft.date=2015-09-01&rft.volume=105&rft.issue=3&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Birth+defects+research.+Part+C%2C+Embryo+today+%3A+reviews&rft.issn=1542-9768&rft_id=info:doi/10.1002%2Fbdrc.21111 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-25 N1 - Date created - 2015-09-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/bdrc.21111 ER - TY - JOUR T1 - The Diplomate in Safety Pharmacology (DSP) certification scheme. AN - 1717484836; 25959882 AB - As with other professional disciplines there is a growing need from within industry as well as global regulatory authorities for implementation of a certification process in order to assure that appropriate expertise is developed and quality standards are identified for professionals involved in the practice of Safety Pharmacology (SP). In order to meet this need, the Safety Pharmacology Society (SPS) has developed the Diplomate in Safety Pharmacology (DSP) certification process. There are many benefits to certification including authentication of the discipline within the overall pharmaceutical community and with regulatory authorities. It also encourages participation in SPS activities by other professionals (toxicologists, clinicians, academics) who wish to broaden their professional expertise. It provides an opportunity for candidates to strengthen their fundamental scientific knowledge, and stimulates the sharing of data, methods and model development in the form of publications and presentations on relevant topics in SP. Accreditation in SP occurs after candidates successfully complete a written certification examination conducted at the annual SPS meeting. The DSP exam consists primarily of material pertinent to the conduct of SP vital function core battery studies (i.e., cardiovascular, respiratory and central nervous systems), supplemental SP studies (i.e., renal/urinary, gastrointestinal, immunology, and hematology), Regulatory Guidelines (ICH Guidelines) as well as relevant cross-functional knowledge (e.g., physiology, pharmacology, toxicology, biochemistry, pathology, pharmacokinetics, dosing formulation, analytical methods, and statistics). Maintenance of the DSP certification results from the accrual of credits which are gained from a range of educational and scientific contributions. Eligibility requirements include a combination of at least a bachelor degree in science and two years of relevant professional SP experience and one poster presentation on a SP topic as first author at a recognized major scientific meeting. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Journal of pharmacological and toxicological methods AU - Authier, Simon AU - Curtis, Michael J AU - Soloviev, Maxim AU - Redfern, Will S AU - Kallman, Mary Jeanne AU - Hamlin, Robert L AU - Leishman, Derek J AU - Valentin, Jean-Pierre AU - Koerner, John E AU - Vargas, Hugo M AU - Botchway, Alfred AU - Correll, Krystle AU - Pugsley, Michael K AD - CiToxLAB North America, 445 Armand-Frappier Boul., Laval, QC H7V 4B3, Canada; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA. Electronic address: AUTHIERS@ca.citoxlab.com. ; Cardiovascular Division, Faculty of Life Sciences & Medicine, Rayne Institutez, King's College London, London SE17EH, UK. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Incyte Corporation, 1801 Augustine Cut-Off Wilmington, DE 19803, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; AstraZeneca R&D, Alderley Park, Cheshire SK10 4TG, UK. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; COVANCE Laboratories, Inc., Greenfield, IN 46140, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; QTest Labs, 6456 Fiesta Drive, Columbus, OH 43235, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Eli Lilly & Company, Indianapolis, IN 46225, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; UCB BioPharma SPRL, Non Clinical Development, Chemin du Foriest, B-1420 Braine-l'Alleud, Belgium. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD 20993, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; XenoMetrics LLC, PO Box 401, Stilwell, KS 66085, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA. ; Safety Pharmacology Society, 1821 Michael Faraday Drive, Reston, VA 20190, USA; Janssen Pharmaceuticals LLC, 1000 Route 202 South, Raritan, NJ 08869, USA. PY - 2015 SP - 1 EP - 4 VL - 75 KW - Index Medicus KW - Respiratory KW - ICH M3 KW - Core battery KW - Central nervous systems KW - ICH S7B KW - Diplomate in Safety Pharmacology (DSP) KW - Certification KW - Safety pharmacology (SP) KW - Cardiovascular KW - ICH S7A KW - Animals KW - Drug Industry -- standards KW - Societies, Scientific -- organization & administration KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Pharmacology -- standards KW - Professional Competence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717484836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmacological+and+toxicological+methods&rft.atitle=The+Diplomate+in+Safety+Pharmacology+%28DSP%29+certification+scheme.&rft.au=Authier%2C+Simon%3BCurtis%2C+Michael+J%3BSoloviev%2C+Maxim%3BRedfern%2C+Will+S%3BKallman%2C+Mary+Jeanne%3BHamlin%2C+Robert+L%3BLeishman%2C+Derek+J%3BValentin%2C+Jean-Pierre%3BKoerner%2C+John+E%3BVargas%2C+Hugo+M%3BBotchway%2C+Alfred%3BCorrell%2C+Krystle%3BPugsley%2C+Michael+K&rft.aulast=Authier&rft.aufirst=Simon&rft.date=2015-09-01&rft.volume=75&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmacological+and+toxicological+methods&rft.issn=1873-488X&rft_id=info:doi/10.1016%2Fj.vascn.2015.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-06 N1 - Date created - 2015-09-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.vascn.2015.04.008 ER - TY - JOUR T1 - Translational biomarkers of acetaminophen-induced acute liver injury AN - 1712777519; PQ0001989125 AB - Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactive oxygen and nitrogen species and mitochondrial injury. The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury. JF - Archives of Toxicology AU - Beger, Richard D AU - Bhattacharyya, Sudeepa AU - Yang, Xi AU - Gill, Pritmohinder S AU - Schnackenberg, Laura K AU - Sun, Jinchun AU - James, Laura P AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, USA, Richard.Beger@fda.hhs.gov Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 1497 EP - 1522 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 89 IS - 9 SN - 0340-5761, 0340-5761 KW - Toxicology Abstracts KW - Translation KW - Liver diseases KW - Injuries KW - Glutathione KW - Mitochondria KW - biomarkers KW - Oxygen KW - Necrosis KW - Protein adducts KW - Reviews KW - Liver KW - Analgesics KW - proteomics KW - Drugs KW - metabolomics KW - Acetaminophen KW - Nitrogen KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712777519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=Translational+biomarkers+of+acetaminophen-induced+acute+liver+injury&rft.au=Beger%2C+Richard+D%3BBhattacharyya%2C+Sudeepa%3BYang%2C+Xi%3BGill%2C+Pritmohinder+S%3BSchnackenberg%2C+Laura+K%3BSun%2C+Jinchun%3BJames%2C+Laura+P&rft.aulast=Beger&rft.aufirst=Richard&rft.date=2015-09-01&rft.volume=89&rft.issue=9&rft.spage=1497&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-015-1519-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 214 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Translation; Liver diseases; Injuries; Glutathione; Mitochondria; biomarkers; Oxygen; Necrosis; Protein adducts; Reviews; Liver; proteomics; Analgesics; Drugs; Acetaminophen; metabolomics; Nitrogen DO - http://dx.doi.org/10.1007/s00204-015-1519-4 ER - TY - JOUR T1 - Biotransformations of organic compounds mediated by cultures of Aspergillus niger AN - 1712772662; PQ0001939480 AB - Many different organic compounds may be converted by microbial biotransformation to high-value products for the chemical and pharmaceutical industries. This review summarizes the use of strains of Aspergillus niger, a well-known filamentous fungus used in numerous biotechnological processes, for biochemical transformations of organic compounds. The substrates transformed include monocyclic, bicyclic, and polycyclic aromatic hydrocarbons; azaarenes, epoxides, chlorinated hydrocarbons, and other aliphatic and aromatic compounds. The types of reactions performed by A. niger, although not unique to this species, are extremely diverse. They include hydroxylation, oxidation of various functional groups, reduction of double bonds, demethylation, sulfation, epoxide hydrolysis, dechlorination, ring cleavage, and conjugation. Some of the products may be useful as new investigational drugs or chemical intermediates. JF - Applied Microbiology and Biotechnology AU - Parshikov, Igor A AU - Woodling, Kellie A AU - Sutherland, John B AD - Institute of Applied Mechanics, Russian Academy of Sciences, Moscow, 119991, Russia, john.sutherland@fda.hhs.gov Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 6971 EP - 6986 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 99 IS - 17 SN - 0175-7598, 0175-7598 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts KW - Transformation KW - Dechlorination KW - Polycyclic aromatic hydrocarbons KW - Epoxides KW - biotransformation KW - Hydrolysis KW - Chlorinated hydrocarbons KW - Hydroxylation KW - Demethylation KW - Aromatic compounds KW - Oxidation KW - Pharmaceuticals KW - Organic compounds KW - Drugs KW - Aspergillus niger KW - J 02310:Genetics & Taxonomy KW - W 30950:Waste Treatment & Pollution Clean-up KW - A 01320:Microbial Degradation KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712772662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Enhancing+STD+Practitioners%27+Understanding+of+Syphilis+Staging%3A+An+Interactive+Case-Conference+Training+Module&rft.au=Thomas%2C+Michael%3BMitchell%2C+Carolyn%3BThornton%2C+Lupita%3BHickenbotham%2C+Algia%3BMcNeese-Ward%2C+Marlene&rft.aulast=Thomas&rft.aufirst=Michael&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 80 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Transformation; Dechlorination; Epoxides; Polycyclic aromatic hydrocarbons; biotransformation; Hydrolysis; Chlorinated hydrocarbons; Hydroxylation; Demethylation; Aromatic compounds; Oxidation; Pharmaceuticals; Organic compounds; Drugs; Aspergillus niger DO - http://dx.doi.org/10.1007/s00253-015-6765-0 ER - TY - JOUR T1 - Timing of Environmental Exposures as a Critical Element in Breast Cancer Risk. AN - 1709707074; 26214118 AB - The role of the chemical environment in disease initiation or progression is becoming more evident. Endocrine disruption via environmental chemicals is now well documented in humans, rodent research models, and wildlife. Breast cancer is an endocrine-based disease whose risk may be modified by environmental exposures. Our purpose is to encourage more investigation into early life environmental exposures as they relate to breast cancer risk factors and disease over a lifetime. The 2009 President's Cancer Panel, 2012 Institute of Medicine, 2013 Interagency Breast Cancer and the Environment Research Coordinating Committee reports, and research publications dated ≥2012 in PubMed were used to inform our perspective. Literature was reviewed and evidence gathered on the effects of the environment on risk of breast cancer or mammary tumor development in animal research models as it pertained to the influence of timing of exposure on later-life outcomes. Evidence has accumulated for several chemicals that environmental factors have a stronger effect on breast cancer risk when exposure occurred early in life. The insecticide, dichlorodiphenyltrichloroethane, is an excellent example and is just one of several chemicals for which there seems to be both animal and human evidence for the developmental basis of adult disease. The developing breast undergoes many changes in early life, leaving it vulnerable to the effects of epigenetic marks, endocrine disruption, and carcinogens. More research is needed in the area of early beginnings of breast cancer, with prevention of the disease as the ultimate goal. JF - The Journal of clinical endocrinology and metabolism AU - Fenton, Suzanne E AU - Birnbaum, Linda S AD - National Toxicology Program (NTP) Laboratory, Division of the NTP (S.E.F.), National Institute of Environmental Health Sciences (L.S.B.), National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 3245 EP - 3250 VL - 100 IS - 9 KW - Endocrine Disruptors KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Time Factors KW - Endocrine Disruptors -- toxicity KW - Breast Neoplasms -- pathology KW - Environmental Exposure KW - Breast Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709707074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Timing+of+Environmental+Exposures+as+a+Critical+Element+in+Breast+Cancer+Risk.&rft.au=Fenton%2C+Suzanne+E%3BBirnbaum%2C+Linda+S&rft.aulast=Fenton&rft.aufirst=Suzanne&rft.date=2015-09-01&rft.volume=100&rft.issue=9&rft.spage=3245&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=1945-7197&rft_id=info:doi/10.1210%2Fjc.2015-2848 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-24 N1 - Date created - 2015-09-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Epidemiology. 1999 Nov;10(6):722-32 [10535787] Reprod Toxicol. 2015 Jul;54:58-65 [25277313] Reprod Toxicol. 2015 Jul;54:136-40 [25554384] Am J Clin Nutr. 2000 May;71(5 Suppl):1344S-52S [10799412] Am J Epidemiol. 2000 Aug 15;152(4):363-70 [10968381] Environ Health Perspect. 2001 Mar;109 Suppl 1:35-47 [11250804] Int J Cancer. 2001 Feb 15;91(4):568-74 [11251983] Toxicol Sci. 2001 Jul;62(1):46-53 [11399792] Toxicol Sci. 2002 May;67(1):63-74 [11961217] Environ Health Perspect. 2002 Jul;110(7):625-8 [12117637] Environ Health Perspect. 2002 Aug;110(8):771-6 [12153757] Environ Health Perspect. 2003 Apr;111(4):389-94 [12676588] Environ Health Perspect. 2004 Feb;112(2):207-14 [14754575] N Engl J Med. 1984 Nov 29;311(22):1393-8 [6493300] Lancet. 1986 May 10;1(8489):1077-81 [2871345] BMJ. 1995 Jul 15;311(6998):171-4 [7613432] Toxicol Appl Pharmacol. 1997 Jan;142(1):192-200 [9007049] Lancet. 1997 Oct 18;350(9085):1131-5 [9343501] Carcinogenesis. 1998 Sep;19(9):1623-9 [9771934] Cad Saude Publica. 1998;14 Suppl 3:125-32 [9819471] J Biochem Mol Toxicol. 1999;13(6):296-302 [10487416] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1509-14 [16896041] Environ Health Perspect. 2007 Oct;115(10):1406-14 [17938728] Chemosphere. 2008 Oct;73(6):999-1004 [18707752] Pediatrics. 2009 May;123(5):e932-9 [19403485] Endocr Rev. 2009 Jun;30(4):293-342 [19502515] Environ Health Perspect. 2010 May;118(5):596-601 [20435547] Environ Health Perspect. 2011 Aug;119(8):1070-6 [21501981] N Engl J Med. 2011 Oct 6;365(14):1304-14 [21991952] Environ Health Perspect. 2011 Dec;119(12):1700-5 [21810551] Annu Rev Pharmacol Toxicol. 2012;52:455-79 [22017681] Environ Health Perspect. 2012 Aug;120(8):1170-6 [22514210] Occup Environ Med. 2012 Sep;69(9):636-42 [22767868] J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):43-61 [23417729] Birth Defects Res C Embryo Today. 2013 Jun;99(2):134-46 [23897597] Obesity (Silver Spring). 2013 Jun;21(6):1079-80 [23784921] Mol Endocrinol. 2013 Oct;27(10):1666-77 [24002655] J Clin Endocrinol Metab. 2015 Aug;100(8):2865-72 [26079774] Regul Toxicol Pharmacol. 2013 Dec;67(3):421-33 [24021539] Pediatrics. 2013 Dec;132(6):1019-27 [24190685] Breast Cancer Res. 2014;16(2):208 [25032259] J Obstet Gynaecol. 2015 Jan;35(1):60-3 [25020211] Sci Total Environ. 2015 Jul 1;520:106-13 [25804877] Biol Reprod. 2001 Oct;65(4):1215-23 [11566746] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1210/jc.2015-2848 ER - TY - JOUR T1 - Prediagnostic Serum Organochlorine Concentrations and Metastatic Prostate Cancer: A Nested Case-Control Study in the Norwegian Janus Serum Bank Cohort. AN - 1709393655; 25734605 AB - Organochlorine (OC) insecticides and polychlorinated biphenyls (PCBs) have been shown to have estrogenic, antiestrogenic, or antiandrogenic properties; as a result, the impact of exposure to these compounds and risk of hormonal cancers, such as prostate cancer, is a concern. We conducted a nested case-control study, using prospectively collected serum, to estimate associations between OC exposures and metastatic prostate cancer in a population-based cohort from Norway. Sera from 150 cases and 314 controls matched on date of blood draw, age at blood draw, and region was used to determine concentrations of 11 OC pesticide metabolites and 34 PCB congeners. Odds ratios (ORs) and 95% confidence intervals (95% CIs) for quartiles of lipid-corrected metabolite levels were calculated using conditional logistic regression. Metastatic prostate cancer was two times as likely among men with serum concentrations of oxychlordane in the highest quartile compared with those in the lowest quartile (OR = 2.03; 95% CI: 1.03, 4.03; p-trend 0.05). Elevated but nonsignificant ORs were estimated for the highest versus lowest quartile of heptachlor epoxide, HCB, and mirex, although these exposures were correlated with oxychlordane. Findings for specific PCB congeners showed a significant inverse association between natural log-transformed lipid-adjusted PCB 44 and metastatic prostate cancer (OR = 0.74; 95% CI: 0.56, 0.97; p-trend = 0.02). Our study highlights the importance of estimating associations with specific OC chemicals and suggests a possible role of OC insecticides and PCBs in the etiology of metastatic prostate cancer. Koutros S, Langseth H, Grimsrud TK, Barr DB, Vermeulen R, Portengen L, Wacholder S, Beane Freeman LE, Blair A, Hayes RB, Rothman N, Engel LS. 2015. Prediagnostic serum organochlorine concentrations and metastatic prostate cancer: a nested case-control study in the Norwegian Janus Serum Bank cohort. Environ Health Perspect 123:867-872; http://dx.doi.org/10.1289/ehp.1408245. JF - Environmental health perspectives AU - Koutros, Stella AU - Langseth, Hilde AU - Grimsrud, Tom K AU - Barr, Dana Boyd AU - Vermeulen, Roel AU - Portengen, Lützen AU - Wacholder, Sholom AU - Freeman, Laura E Beane AU - Blair, Aaron AU - Hayes, Richard B AU - Rothman, Nathaniel AU - Engel, Lawrence S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 867 EP - 872 VL - 123 IS - 9 KW - Hydrocarbons, Chlorinated KW - 0 KW - Insecticides KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Prospective Studies KW - Logistic Models KW - Humans KW - Polychlorinated Biphenyls -- blood KW - Adult KW - Neoplasm Metastasis KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Norway KW - Male KW - Prostatic Neoplasms -- pathology KW - Hydrocarbons, Chlorinated -- blood KW - Prostatic Neoplasms -- blood KW - Prostatic Neoplasms -- chemically induced KW - Insecticides -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709393655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.atitle=Surgical+Smoke+and+Healthcare+Worker+Health+and+Safety&rft.au=Steege%2C+Andrea%3BBoiano%2C+Jim%3BHaring+Sweeney%2C+Marie&rft.aulast=Steege&rft.aufirst=Andrea&rft.date=2015-10-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-31 N1 - Date created - 2015-09-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2010 Jun;118(6):796-802 [20146964] J Expo Sci Environ Epidemiol. 2010 Jul;20(5):434-45 [19513097] J Clin Oncol. 2010 Jul 20;28(21):3457-62 [20566993] Chemosphere. 2010 Sep;81(4):464-8 [20817259] Am J Epidemiol. 2013 Jan 1;177(1):59-74 [23171882] Lancet Oncol. 2013 Apr;14(4):287-8 [23499544] J Occup Environ Med. 2003 Jul;45(7):692-702 [12855910] Chemosphere. 2004 Mar;54(10):1509-20 [14659953] Environ Health Perspect. 1989 May;81:225-39 [2503374] Environ Health Perspect. 1997 Jan;105(1):13-4 [9074863] Annu Rev Public Health. 1997;18:211-44 [9143718] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] Int Arch Occup Environ Health. 2004 Nov;77(8):559-70 [15688248] Environ Res. 2005 May;98(1):104-13 [15721890] J Occup Environ Med. 2006 Jul;48(7):700-7 [16832227] Environ Health Perspect. 2006 Oct;114(10):1508-14 [17035134] Int J Cancer. 2007 Feb 1;120(3):642-9 [17096337] Cancer Res. 2007 Jun 1;67(11):5545-52 [17545638] Int J Cancer. 2007 Oct 1;121(7):1571-8 [17450530] J Natl Cancer Inst. 2007 Dec 19;99(24):1881-7 [18073376] Endocr Rev. 2009 Jun;30(4):293-342 [19502515] Mol Nutr Food Res. 2009 Nov;53(11):1438-51 [19842105] Environ Health Perspect. 2009 Oct;117(10):1514-9 [20019899] Environ Health Perspect. 2010 Jan;118(1):60-6 [20056587] Acta Oncol. 2010 Apr;49(3):368-77 [20059313] Environ Health Perspect. 2010 May;118(5):659-65 [20435560] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408245 ER - TY - JOUR T1 - Application of Physiologically Based Absorption Modeling for Amphetamine Salts Drug Products in Generic Drug Evaluation AN - 1709191129; PQ0001891325 AB - Amphetamine (AMP) salts-based extended-release (ER) drug products are widely used for the treatment of attention deficit hyperactivity disorder. We developed physiologically based absorption models for mixed AMP salts ER capsules and dextroamphetamine sulfate ER capsules to address specific questions raised during generic drug postmarketing surveillance and bioequivalence (BE) guidance development. The models were verified against several data sets. Virtual BE simulations were conducted to assess BE in various populations other than normal healthy subjects where BE studies are generally conducted for approval. The models were also used to predict pharmacokinetics (PK) for hypothetical formulations having dissolution profiles falling within specification after the development of in vitro-in vivo relation. Finally, we demonstrated how to use the models to test sensitivity of PK metrics to the changes in formulation variables. copyright 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3170-3182, 2015 JF - Journal of Pharmaceutical Sciences AU - Babiskin, Andrew H AU - Zhang, Xinyuan AD - Division of Quantitative Methods and Modeling, Office of Research and Standards, Office of Generic Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, 20993. Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 3170 EP - 3182 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 9 SN - 0022-3549, 0022-3549 KW - Toxicology Abstracts KW - Salts KW - Data processing KW - Attention deficit hyperactivity disorder KW - Dissolution KW - Drug development KW - Amphetamine KW - AMP KW - Drug abuse KW - Pharmacokinetics KW - Models KW - Sulfate KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709191129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Application+of+Physiologically+Based+Absorption+Modeling+for+Amphetamine+Salts+Drug+Products+in+Generic+Drug+Evaluation&rft.au=Babiskin%2C+Andrew+H%3BZhang%2C+Xinyuan&rft.aulast=Babiskin&rft.aufirst=Andrew&rft.date=2015-09-01&rft.volume=104&rft.issue=9&rft.spage=3170&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24474 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Salts; Data processing; Attention deficit hyperactivity disorder; Dissolution; AMP; Amphetamine; Drug development; Drug abuse; Pharmacokinetics; Sulfate; Models DO - http://dx.doi.org/10.1002/jps.24474 ER - TY - JOUR T1 - Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses. AN - 1708158449; 26048654 AB - Triclosan is an antimicrobial chemical incorporated into many personal, medical and household products. Approximately, 75% of the U.S. population has detectable levels of triclosan in their urine, and although it is not typically considered a contact sensitizer, recent studies have begun to link triclosan exposure with augmented allergic disease. We examined the effects of dermal triclosan exposure on the skin and lymph nodes of mice and in a human skin model to identify mechanisms for augmenting allergic responses. Triclosan (0%-3%) was applied topically at 24-h intervals to the ear pinnae of OVA-sensitized BALB/c mice. Skin and draining lymph nodes were evaluated for cellular responses and cytokine expression over time. The effects of triclosan (0%-0.75%) on cytokine expression in a human skin tissue model were also examined. Exposure to triclosan increased the expression of TSLP, IL-1β, and TNF-α in the skin with concomitant decreases in IL-25, IL-33, and IL-1α. Similar changes in TSLP, IL1B, and IL33 expression occurred in human skin. Topical application of triclosan also increased draining lymph node cellularity consisting of activated CD86(+)GL-7(+) B cells, CD80(+)CD86(+) dendritic cells, GATA-3(+)OX-40(+)IL-4(+)IL-13(+) Th2 cells and IL-17 A(+) CD4 T cells. In vivo antibody blockade of TSLP reduced skin irritation, IL-1β expression, lymph node cellularity, and Th2 responses augmented by triclosan. Repeated dermal exposure to triclosan induces TSLP expression in skin tissue as a potential mechanism for augmenting allergic responses. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Marshall, Nikki B AU - Lukomska, Ewa AU - Long, Carrie M AU - Kashon, Michael L AU - Sharpnack, Douglas D AU - Nayak, Ajay P AU - Anderson, Katie L AU - Jean Meade, B AU - Anderson, Stacey E AD - *Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505;Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 andVet Path Services, Inc., Mason 45040, Ohio nmarshall@cdc.gov. ; *Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505; ; Biostatistics and Epidemiology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505 and. ; Vet Path Services, Inc., Mason 45040, Ohio. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 127 EP - 139 VL - 147 IS - 1 KW - Anti-Infective Agents, Local KW - 0 KW - Cytokines KW - thymic stromal lymphopoietin KW - Triclosan KW - 4NM5039Y5X KW - Index Medicus KW - TSLP KW - triclosan KW - Th2 KW - OVA KW - allergy KW - Animals KW - Humans KW - In Vitro Techniques KW - Adaptive Immunity -- drug effects KW - Mice KW - Mice, Inbred BALB C KW - Lymph Nodes -- drug effects KW - Administration, Topical KW - Dermatitis, Allergic Contact -- immunology KW - Stromal Cells -- drug effects KW - Cytokines -- biosynthesis KW - Th2 Cells -- drug effects KW - Anti-Infective Agents, Local -- toxicity KW - Triclosan -- toxicity KW - Dermatitis, Allergic Contact -- pathology KW - Stromal Cells -- metabolism KW - Th2 Cells -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708158449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Triclosan+Induces+Thymic+Stromal+Lymphopoietin+in+Skin+Promoting+Th2+Allergic+Responses.&rft.au=Marshall%2C+Nikki+B%3BLukomska%2C+Ewa%3BLong%2C+Carrie+M%3BKashon%2C+Michael+L%3BSharpnack%2C+Douglas+D%3BNayak%2C+Ajay+P%3BAnderson%2C+Katie+L%3BJean+Meade%2C+B%3BAnderson%2C+Stacey+E&rft.aulast=Marshall&rft.aufirst=Nikki&rft.date=2015-09-01&rft.volume=147&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv113 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-23 N1 - Date created - 2015-08-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Allergy Clin Immunol. 2012 Aug;130(2):453-60.e7 [22704536] Allergy. 2013 Jan;68(1):84-91 [23146048] PLoS One. 2013;8(1):e51268 [23300949] Toxicol Sci. 2013 Mar;132(1):96-106 [23192912] Adv Pharmacol. 2013;66:129-55 [23433457] J Invest Dermatol. 2013 Dec;133(12):2714-21 [23698100] Pediatr Allergy Immunol. 2013 Dec;24(8):762-71 [24299467] Ann Allergy Asthma Immunol. 2014 Feb;112(2):179-181.e2 [24468262] N Engl J Med. 2014 May 29;370(22):2102-10 [24846652] J Immunol. 2015 Feb 1;194(3):1372-80 [25539812] Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1536-41 [19188585] PLoS Biol. 2009 May 19;7(5):e1000067 [19557146] J Invest Dermatol. 2010 Oct;130(10):2505-7 [20555350] J Allergy Clin Immunol. 2010 Nov;126(5):976-84, 984.e1-5 [21050944] Environ Health Perspect. 2011 Mar;119(3):390-6 [21062687] Nature. 2011 Dec 8;480(7376):S2-3 [22158296] Mucosal Immunol. 2012 May;5(3):342-51 [22354320] Genome Res. 2012 May;22(5):850-9 [22310478] Allergy Asthma Proc. 2014 Nov-Dec;35(6):475-81 [25584915] J Occup Environ Med. 2014 Aug;56(8):834-9 [25099409] J Immunotoxicol. 2016;13(2):165-72 [25812624] Environ Toxicol. 2016 May;31(5):609-23 [25410937] J Exp Med. 2001 Feb 5;193(3):387-92 [11157058] Environ Sci Technol. 2002 Mar 15;36(6):1202-11 [11944670] Nat Immunol. 2002 Jul;3(7):673-80 [12055625] J Exp Med. 2003 Jul 21;198(2):315-24 [12860930] Dermatologica. 1979;158(5):379-83 [374145] J Hosp Infect. 1988 Apr;11(3):226-43 [2899107] J Hosp Infect. 1990 Feb;15(2):143-8 [1969436] Nature. 1998 Aug 6;394(6693):531-2 [9707111] J Biol Chem. 1999 Apr 16;274(16):11110-4 [10196195] Nature. 1999 Apr 1;398(6726):383-4 [10201369] J Exp Med. 2005 Aug 15;202(4):541-9 [16103410] J Exp Med. 2005 Sep 19;202(6):829-39 [16172260] Nat Immunol. 2005 Oct;6(10):1047-53 [16142237] J Exp Med. 2005 Nov 7;202(9):1213-23 [16275760] J Immunol. 2007 Mar 15;178(6):3373-7 [17339431] J Clin Invest. 2007 Dec;117(12):3868-78 [18060034] Environ Health Perspect. 2008 Mar;116(3):303-7 [18335095] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv113 ER - TY - JOUR T1 - Acute and recent air pollution exposure and cardiovascular events at labour and delivery. AN - 1707558434; 26105036 AB - To study the relationship between acute air pollution exposure and cardiovascular events during labour/delivery. The Consortium on Safe Labor (2002-2008), an observational US cohort with 223,502 singleton deliveries provided electronic medical records. Air pollution exposure was estimated by modified Community Multiscale Air Quality models. Cardiovascular events (cardiac failure/arrest, stroke, myocardial infarcts and other events) were recorded in the hospital discharge records for 687 pregnancies (0.3%). Logistic regression with generalised estimating equations estimated the relationship between cardiovascular events and daily air pollutant levels for delivery day and the 7 days preceding delivery. Increased odds of cardiovascular events were observed for each IQR increase in exposure to nitric oxides at 5 and 6 days prior to delivery (OR=1.17, 99% CI 1.04 to 1.30 and OR=1.15, 1.03 to 1.28, respectively). High exposure to toxic air pollution species such as ethylbenzene (OR=1.50, 1.08 to 2.09), m-xylene (OR=1.54, 1.11 to 2.13), o-xylene (OR=1.51, 1.09 to 2.09), p-xylene (OR=1.43, 1.03 to 1.99) and toluene (OR=1.42, 1.02 to 1.97) at 5 days prior to delivery were also associated with cardiovascular events. Decreased odds of events were observed with exposure to ozone. Air pollution in the days prior to delivery, especially nitrogen oxides and some toxic air pollution species, was associated with increased risk of cardiovascular events during the labour/delivery admission. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Heart (British Cardiac Society) AU - Männistö, Tuija AU - Mendola, Pauline AU - Laughon Grantz, Katherine AU - Leishear, Kira AU - Sundaram, Rajeshwari AU - Sherman, Seth AU - Ying, Qi AU - Liu, Danping AD - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA Northern Finland Laboratory Centre NordLab, Oulu, Finland Department of Clinical Chemistry, University of Oulu, Oulu, Finland Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland Department of Chronic Disease Prevention, National Institute for Health and Welfare, Oulu, Finland. ; Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA. ; Glotech Inc., Rockville, Maryland, USA US Food and Drug Administration, Silver Spring, Maryland, USA. ; Biostatistics and Bioinformatics Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA. ; The EMMES Corporation, Rockville, Maryland, USA. ; Zachry Department of Civil Engineering, Texas A&M University, College Station, Texas, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 1491 EP - 1498 VL - 101 IS - 18 KW - Nitrogen Oxides KW - 0 KW - Xylenes KW - Ozone KW - 66H7ZZK23N KW - Abridged Index Medicus KW - Index Medicus KW - Electronic Health Records KW - Delivery, Obstetric -- mortality KW - Risk Factors KW - Humans KW - Adult KW - Outcome Assessment (Health Care) KW - Delivery, Obstetric -- methods KW - United States -- epidemiology KW - Male KW - Female KW - Risk Assessment KW - Pregnancy KW - Ozone -- analysis KW - Air Pollution -- analysis KW - Pregnancy Complications, Cardiovascular -- epidemiology KW - Environmental Exposure -- analysis KW - Nitrogen Oxides -- analysis KW - Xylenes -- toxicity KW - Air Pollution -- adverse effects KW - Pregnancy Complications, Cardiovascular -- prevention & control KW - Pregnancy Complications, Cardiovascular -- chemically induced KW - Environmental Exposure -- adverse effects KW - Nitrogen Oxides -- toxicity KW - Xylenes -- analysis KW - Ozone -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707558434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Heart+%28British+Cardiac+Society%29&rft.atitle=Acute+and+recent+air+pollution+exposure+and+cardiovascular+events+at+labour+and+delivery.&rft.au=M%C3%A4nnist%C3%B6%2C+Tuija%3BMendola%2C+Pauline%3BLaughon+Grantz%2C+Katherine%3BLeishear%2C+Kira%3BSundaram%2C+Rajeshwari%3BSherman%2C+Seth%3BYing%2C+Qi%3BLiu%2C+Danping&rft.aulast=M%C3%A4nnist%C3%B6&rft.aufirst=Tuija&rft.date=2015-09-01&rft.volume=101&rft.issue=18&rft.spage=1491&rft.isbn=&rft.btitle=&rft.title=Heart+%28British+Cardiac+Society%29&rft.issn=1468-201X&rft_id=info:doi/10.1136%2Fheartjnl-2014-307366 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-16 N1 - Date created - 2015-08-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/heartjnl-2014-307366 ER - TY - JOUR T1 - Reproductive hormone levels and differential mitochondria-related oxidative gene expression as potential mechanisms for gender differences in cardiosensitivity to Doxorubicin in tumor-bearing spontaneously hypertensive rats. AN - 1705735414; 26108538 AB - Chemotherapy with doxorubicin (Dox) causes dose-limiting cardiotoxicity. We investigated the role that gender has on cardiosensitivity to Dox treatment by evaluating reproductive hormone levels in male, castrated male (c-male), female and ovariectomized female (o-female) adult spontaneously hypertensive rats (SHRs) and expression of mitochondria-related genes in male and female adult SHRs. SST-2 breast tumor-bearing SHRs were treated with saline, Dox, dexrazoxane (Drz) or both Dox and Drz and monitored for 14 days. Tumor size was used to monitor anticancer activity. Heart weight, cardiac lesion score and serum levels of cardiac troponin T (cTnT) were used to determine cardiotoxicity. Serum estradiol (E2) and testosterone were evaluated using electrochemiluminescence immunoassays. Expression of mitochondria-related genes was profiled in heart by MitoChip array analyses. Dox significantly reduced tumor volume (±Drz) and increased heart weight in all genders (13-30% vs. control). Higher heart lesion scores were observed in reproductively normal animals (male 2.9, female 2.2) than in hormone-deficient animals (c-male 1.7, o-female 1.9). Lesion score and cTnT inversely correlated with hormone levels. Reduced levels of both sex hormones were observed after Dox treatment. Gene expression analyses of Dox-treated hearts showed significant differential expression of oxidative stress genes in male hearts and apoptotic genes in both male and female hearts. Our results demonstrate that adult tumor-bearing male SHRs are more cardiosensitive to Dox than female or hormone-deficient animals. We provide evidence to suggest that reproductive hormones negatively regulate or are inhibited by Dox-induced cardiotoxicity and the selective cytotoxic mechanism likely functions through the greater activation of oxidative stress and apoptosis in male SHRs. JF - Cancer chemotherapy and pharmacology AU - Gonzalez, Yanira AU - Pokrzywinski, Kaytee L AU - Rosen, Elliot T AU - Mog, Steven AU - Aryal, Baikuntha AU - Chehab, Leena M AU - Vijay, Vikrant AU - Moland, Carrie L AU - Desai, Varsha G AU - Dickey, Jennifer S AU - Rao, V Ashutosh AD - Laboratory of Chemistry, Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave/Bldg 52/72 Rm 2212, Silver Spring, MD, 20993, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 447 EP - 459 VL - 76 IS - 3 KW - Gonadal Steroid Hormones KW - 0 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Rats KW - Models, Animal KW - Gene Expression -- drug effects KW - Animals KW - Rats, Inbred SHR KW - Sex Factors KW - Apoptosis -- physiology KW - Mammary Neoplasms, Experimental -- drug therapy KW - Oxidative Stress -- genetics KW - Mammary Neoplasms, Experimental -- metabolism KW - Male KW - Female KW - Hypertension -- chemically induced KW - Doxorubicin -- pharmacology KW - Heart Diseases -- chemically induced KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism KW - Heart Diseases -- metabolism KW - Gonadal Steroid Hormones -- metabolism KW - Doxorubicin -- toxicity KW - Mitochondria -- genetics KW - Hypertension -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705735414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Reproductive+hormone+levels+and+differential+mitochondria-related+oxidative+gene+expression+as+potential+mechanisms+for+gender+differences+in+cardiosensitivity+to+Doxorubicin+in+tumor-bearing+spontaneously+hypertensive+rats.&rft.au=Gonzalez%2C+Yanira%3BPokrzywinski%2C+Kaytee+L%3BRosen%2C+Elliot+T%3BMog%2C+Steven%3BAryal%2C+Baikuntha%3BChehab%2C+Leena+M%3BVijay%2C+Vikrant%3BMoland%2C+Carrie+L%3BDesai%2C+Varsha+G%3BDickey%2C+Jennifer+S%3BRao%2C+V+Ashutosh&rft.aulast=Gonzalez&rft.aufirst=Yanira&rft.date=2015-09-01&rft.volume=76&rft.issue=3&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=1432-0843&rft_id=info:doi/10.1007%2Fs00280-015-2786-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-17 N1 - Date created - 2015-08-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00280-015-2786-8 ER - TY - JOUR T1 - A Survey of Neonatal Pharmacokinetic and Pharmacodynamic Studies in Pediatric Drug Development. AN - 1705476582; 25975723 AB - Conducting clinical trials in neonates is challenging, and knowledge gaps in neonatal clinical pharmacology exist. We surveyed the US Food and Drug Administration databases and identified 43 drugs studied in neonates or referring to neonates between 1998 and 2014. Twenty drugs were approved in neonates. For 10 drugs, approval was based on efficacy data in neonates, supplemented by pharmacokinetic data for four drugs. Approval for neonates was based on full extrapolation from older patients for six drugs, and partial extrapolation was the basis of approval for four drugs. Dosing recommendations differed from older patients for most drugs, and used body-size based adjustment in neonates. Trial failures were associated with various factors including inappropriate dose selection. Successful drug development in neonates could be facilitated by an improved understanding of the natural history and pathophysiology of neonatal diseases and identification and validation of clinically relevant biomarkers. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Clinical pharmacology and therapeutics AU - Wang, J AU - Avant, D AU - Green, D AU - Seo, S AU - Fisher, J AU - Mulberg, A E AU - McCune, S K AU - Burckart, G J AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ; Office of Pediatric Therapeutics, Commissioner's Office, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ; Division of Biochemical Toxicology, National Center for Toxicology Research, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. ; Division of Gastroenterology and Inborn Errors Products, Office of Drug Evaluation III, Center for Drug Evaluation and Research, Silver Spring, Maryland, USA, U.S. Food and Drug Administration. ; Office of Translational Sciences, Center for Drug Evaluation and Research U.S. Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 328 EP - 335 VL - 98 IS - 3 KW - Pharmaceutical Preparations KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Computer Simulation KW - Dose-Response Relationship, Drug KW - Risk Factors KW - Humans KW - Infant, Newborn KW - Drug-Related Side Effects and Adverse Reactions -- etiology KW - Algorithms KW - Drug-Related Side Effects and Adverse Reactions -- prevention & control KW - Drug Dosage Calculations KW - Models, Biological KW - Risk Assessment KW - Pharmaceutical Preparations -- administration & dosage KW - Infant, Newborn, Diseases -- diagnosis KW - Drug Discovery KW - Pharmaceutical Preparations -- metabolism KW - Infant, Newborn, Diseases -- metabolism KW - Clinical Trials as Topic KW - Pharmacokinetics KW - Infant, Newborn, Diseases -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705476582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=A+Survey+of+Neonatal+Pharmacokinetic+and+Pharmacodynamic+Studies+in+Pediatric+Drug+Development.&rft.au=Wang%2C+J%3BAvant%2C+D%3BGreen%2C+D%3BSeo%2C+S%3BFisher%2C+J%3BMulberg%2C+A+E%3BMcCune%2C+S+K%3BBurckart%2C+G+J&rft.aulast=Wang&rft.aufirst=J&rft.date=2015-09-01&rft.volume=98&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1002%2Fcpt.149 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-03 N1 - Date created - 2015-08-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cpt.149 ER - TY - JOUR T1 - Product quality for nanomaterials: current U.S. experience and perspective AN - 1705076003; PQ0001829260 AB - In recent years, there has been an increased focus on developing novel drug delivery systems and targeted therapies through the use of nanotechnology and nanomaterials. Such focus is translating to an increasing number of investigational new drug (IND) applications, new drug applications (NDAs), and abbreviated new drug applications (ANDAs) for drug products containing nanomaterials to the United States Food and Drug Administration (FDA). Although subject to the same rigorous regulatory standards and regulatory pathways as any drug product, unique properties that arise from the small size, large surface area, and polydispersity of nanomaterials may lead to additional scientific considerations when following current FDA guidelines and practices for drug evaluation. This review article will discuss these scientific considerations based on the experience with FDA-approved drug products containing nanomaterials. WIREs Nanomed Nanobiotechnol 2015, 7:640-654. doi: 10.1002/wnan.1338 For further resources related to this article, please visit the WIREs website . JF - Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology AU - Tyner, Katherine M AU - Zou, Peng AU - Yang, Xiaochuan AU - Zhang, Hailing AU - Cruz, Celia N AU - Lee, Sau L AD - CDER/OPQ/SRS, FDA, Silver Springs, MD, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 640 EP - 654 PB - Wiley-Blackwell, Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 7 IS - 5 SN - 1939-5116, 1939-5116 KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Surface area KW - Drug development KW - nanotechnology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705076003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.atitle=Product+quality+for+nanomaterials%3A+current+U.S.+experience+and+perspective&rft.au=Tyner%2C+Katherine+M%3BZou%2C+Peng%3BYang%2C+Xiaochuan%3BZhang%2C+Hailing%3BCruz%2C+Celia+N%3BLee%2C+Sau+L&rft.aulast=Tyner&rft.aufirst=Katherine&rft.date=2015-09-01&rft.volume=7&rft.issue=5&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=Wiley+Interdisciplinary+Reviews%3A+Nanomedicine+and+Nanobiotechnology&rft.issn=19395116&rft_id=info:doi/10.1002%2Fwnan.1338 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Drug delivery; Surface area; Drug development; nanotechnology DO - http://dx.doi.org/10.1002/wnan.1338 ER - TY - JOUR T1 - Prescription Opioids. IV: Disposition of Hydrocodone in Oral Fluid and Blood Following Single-Dose Administration. AN - 1704347614; 25962610 AB - The Substance Abuse and Mental Health Services Administration (SAMHSA) is currently evaluating hydrocodone (HC) for inclusion in the Mandatory Guidelines for Federal Workplace Drug Testing Programs. This study evaluated the time course of HC, norhydrocodone (NHC), dihydrocodeine (DHC) and hydromorphone (HM) in paired oral fluid and whole blood specimens by liquid chromatography-tandem mass spectrometry (limit of quantitation = 1 ng/mL of oral fluid, 5 ng/mL of blood) over a 52-h period. A single dose of HC bitartrate, 20 mg, was administered to 12 subjects. Analyte prevalence was as follows: oral fluid, HC > NHC > DHC; and blood, HC > NHC. HM was not detected in any specimen. HC was frequently detected within 15 min in oral fluid and 30 min in blood. Mean oral fluid to blood (OF : BL) ratios and correlations were 3.2 for HC (r = 0.73) and 0.7 for NHC (r = 0.42). The period of detection for oral fluid exceeded blood at all evaluated thresholds. At a 1-ng/mL threshold for oral fluid, mean detection time was 30 h for HC and 18 h for NHC and DHC. This description of HC and metabolite disposition in oral fluid following single-dose administration provides valuable interpretive guidance of HC test results. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Journal of analytical toxicology AU - Cone, Edward J AU - DePriest, Anne Z AU - Heltsley, Rebecca AU - Black, David L AU - Mitchell, John M AU - LoDico, Charles AU - Flegel, Ron AD - Johns Hopkins School of Medicine, Baltimore, MD, USA. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA University of Tennessee Health Science Center, College of Pharmacy, Memphis, TN, USA anne.depriest@aegislabs.com. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA. ; RTI International, Research Triangle Park, NC, USA. ; Division of Workplace Programs, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 510 EP - 518 VL - 39 IS - 7 KW - Analgesics, Opioid KW - 0 KW - Prescription Drugs KW - norhydrocodone KW - Hydrocodone KW - 6YKS4Y3WQ7 KW - dihydrocodeine KW - N9I9HDB855 KW - Hydromorphone KW - Q812464R06 KW - Codeine KW - Q830PW7520 KW - Index Medicus KW - Hydromorphone -- pharmacokinetics KW - Reproducibility of Results KW - Codeine -- analogs & derivatives KW - Biotransformation KW - Humans KW - Codeine -- pharmacokinetics KW - Chromatography, Liquid KW - Predictive Value of Tests KW - Healthy Volunteers KW - Tissue Distribution KW - Tandem Mass Spectrometry KW - Limit of Detection KW - Hydrocodone -- blood KW - Analgesics, Opioid -- blood KW - Prescription Drugs -- administration & dosage KW - Hydrocodone -- analogs & derivatives KW - Analgesics, Opioid -- pharmacokinetics KW - Saliva -- metabolism KW - Analgesics, Opioid -- administration & dosage KW - Hydrocodone -- pharmacokinetics KW - Hydrocodone -- administration & dosage KW - Prescription Drugs -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704347614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Prescription+Opioids.+IV%3A+Disposition+of+Hydrocodone+in+Oral+Fluid+and+Blood+Following+Single-Dose+Administration.&rft.au=Cone%2C+Edward+J%3BDePriest%2C+Anne+Z%3BHeltsley%2C+Rebecca%3BBlack%2C+David+L%3BMitchell%2C+John+M%3BLoDico%2C+Charles%3BFlegel%2C+Ron&rft.aulast=Cone&rft.aufirst=Edward&rft.date=2015-09-01&rft.volume=39&rft.issue=7&rft.spage=510&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbkv050 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-18 N1 - Date created - 2015-08-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bkv050 ER - TY - JOUR T1 - Psychosocial work characteristics of personal care and service occupations: a process for developing meaningful measures for a multiethnic workforce AN - 1704346073; 4694590 AB - Background and objectives. Despite their rapid increase in number, workers in personal care and service occupations are underrepresented in research on psychosocial work characteristics and occupational health. Some of the research challenges stem from the high proportion of immigrants in these occupations. Language barriers, low literacy, and cultural differences as well as their nontraditional work setting (i.e., providing service for one person in his/her home) make generic questionnaire measures inadequate for capturing salient aspects of personal care and service work. This study presents strategies for (1) identifying psychosocial work characteristics of home care workers that may affect their occupational safety and health and (2) creating survey measures that overcome barriers posed by language, low literacy, and cultural differences. Reprinted by permission of Taylor & Francis Ltd. JF - Ethnicity and health AU - Hoppe, Annekatrin AU - Heaney, Catherine A AU - Fujishiro, Kaori AU - Gong, Fang AU - Baron, Sherry AD - Stanford University ; National Institute for Occupational Safety and Health ; Ball State University Y1 - 2015/09// PY - 2015 DA - Sep 2015 SP - 474 EP - 492 VL - 20 IS - 5 SN - 1355-7858, 1355-7858 KW - Sociology KW - Qualitative analysis KW - Workers KW - Language barrier KW - Health care KW - Caring KW - Cultural differences KW - Occupations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704346073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+and+health&rft.atitle=Psychosocial+work+characteristics+of+personal+care+and+service+occupations%3A+a+process+for+developing+meaningful+measures+for+a+multiethnic+workforce&rft.au=Hoppe%2C+Annekatrin%3BHeaney%2C+Catherine+A%3BFujishiro%2C+Kaori%3BGong%2C+Fang%3BBaron%2C+Sherry&rft.aulast=Hoppe&rft.aufirst=Annekatrin&rft.date=2015-09-01&rft.volume=20&rft.issue=5&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Ethnicity+and+health&rft.issn=13557858&rft_id=info:doi/10.1080%2F13557858.2014.925095 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - 2039 13521; 10519 3279 971 3286; 3121 3198 3549 2688 2449 10404; 8864; 5775 13521; 7228 7239 7226; 13682 DO - http://dx.doi.org/10.1080/13557858.2014.925095 ER - TY - JOUR T1 - An in vitro combined antibiotic-antibody treatment eliminates toxicity from Shiga toxin-producing Escherichia coli. AN - 1704345237; 26100707 AB - Treating Shiga toxin-producing Escherichia coli (STEC) gastrointestinal infections is difficult. The utility of antibiotics for STEC treatment is controversial, since antibiotic resistance among STEC isolates is widespread and certain antibiotics dramatically increase the expression of Shiga toxins (Stxs), which are some of the most important virulence factors in STEC. Stxs contribute to life-threatening hemolytic uremic syndrome (HUS), which develops in considerable proportions of patients with STEC infections. Understanding the antibiotic resistance profiles of STEC isolates and the Stx induction potential of promising antibiotics is essential for evaluating any antibiotic treatment of STEC. In this study, 42 O157:H7 or non-O157 STEC isolates (including the "big six" serotypes) were evaluated for their resistance against 22 antibiotics by using an antibiotic array. Tigecycline inhibited the growth of all of the tested STEC isolates and also inhibited the production of Stxs (Stx2 in particular). In combination with neutralizing antibodies to Stx1 and Stx2, the tigecycline-antibody treatment fully protected Vero cells from Stx toxicity, even when the STEC bacteria and the Vero cells were cultured together. The combination of an antibiotic such as tigecycline with neutralizing antibodies presents a promising strategy for future STEC treatments. Copyright © 2015, American Society for Microbiology. All Rights Reserved. JF - Antimicrobial agents and chemotherapy AU - Skinner, Craig AU - Zhang, Guodong AU - Patfield, Stephanie AU - He, Xiaohua AD - Western Regional Research Center, U.S. Department of Agriculture, Agricultural Research Service, Albany, California, USA. ; Center for Food Safety and Applied Nutrition, Food and Drug Administration, Division of Microbiology, College Park, Maryland, USA. ; Western Regional Research Center, U.S. Department of Agriculture, Agricultural Research Service, Albany, California, USA xiaohua.he@ars.usda.gov. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 5435 EP - 5444 VL - 59 IS - 9 KW - Anti-Bacterial Agents KW - 0 KW - Antibodies KW - Antibodies, Neutralizing KW - tigecycline KW - 70JE2N95KR KW - Minocycline KW - FYY3R43WGO KW - Index Medicus KW - Animals KW - Minocycline -- pharmacology KW - Lactobacillus acidophilus -- physiology KW - Cell Survival -- drug effects KW - Cercopithecus aethiops KW - Enzyme-Linked Immunosorbent Assay KW - Vero Cells KW - Antibodies, Neutralizing -- pharmacology KW - Minocycline -- analogs & derivatives KW - Shiga-Toxigenic Escherichia coli -- drug effects KW - Antibodies -- pharmacology KW - Anti-Bacterial Agents -- adverse effects KW - Anti-Bacterial Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704345237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=An+in+vitro+combined+antibiotic-antibody+treatment+eliminates+toxicity+from+Shiga+toxin-producing+Escherichia+coli.&rft.au=Skinner%2C+Craig%3BZhang%2C+Guodong%3BPatfield%2C+Stephanie%3BHe%2C+Xiaohua&rft.aulast=Skinner&rft.aufirst=Craig&rft.date=2015-09-01&rft.volume=59&rft.issue=9&rft.spage=5435&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=1098-6596&rft_id=info:doi/10.1128%2FAAC.00763-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-18 N1 - Date created - 2015-08-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: PLoS One. 2012;7(3):e33637 [22432037] MMWR Recomm Rep. 2009 Oct 16;58(RR-12):1-14 [19834454] Toxins (Basel). 2012 Jul;4(7):487-504 [22852065] J Clin Microbiol. 2012 Sep;50(9):2951-63 [22760050] PLoS One. 2013;8(10):e76368 [24146860] Toxins (Basel). 2013 Oct;5(10):1845-58 [24152988] Ann Clin Microbiol Antimicrob. 2013;12:19 [23941473] PLoS One. 2014;9(5):e95281 [24871339] PLoS One. 2014;9(6):e99854 [24914553] J Clin Microbiol. 2014 Jul;52(7):2346-51 [24759708] Antimicrob Agents Chemother. 2014 Dec;58(12):7560-4 [25267665] J Bacteriol. 1999 Mar;181(6):1767-78 [10074068] J Clin Microbiol. 2012 Nov;50(11):3485-92 [22895033] J Immunol Methods. 2013 Mar 29;389(1-2):18-28 [23279946] Drugs. 2013 Feb;73(2):159-77 [23371303] PLoS One. 2013;8(3):e59760 [23555772] Int J Food Microbiol. 2013 Jun 3;164(1):36-45 [23587712] Emerg Infect Dis. 2013 Jun;19(6):870-8 [23731823] Infection. 2013 Jun;41(3):669-73 [23292662] J Infect Dis. 2002 Jan 1;185(1):74-84 [11756984] N Engl J Med. 2000 Jun 29;342(26):1930-6 [10874060] PLoS One. 2013;8(9):e76563 [24069462] Mol Microbiol. 2002 May;44(4):957-70 [12010491] J Biol Chem. 2004 Jun 25;279(26):27511-7 [15075327] Epidemiol Infect. 1987 Dec;99(3):613-24 [3322851] Mol Microbiol. 1991 Aug;5(8):1817-22 [1766367] Diagn Microbiol Infect Dis. 1993 Mar-Apr;16(3):185-9 [8477572] Int J Food Microbiol. 2010 Jan 1;136(3):290-4 [19875188] Diagn Microbiol Infect Dis. 2011 Jun;70(2):270-3 [21596226] Ann Pharmacother. 2011 Jul;45(7-8):1005-10 [21730279] N Engl J Med. 2011 Nov 10;365(19):1771-80 [21696328] Arch Microbiol. 2011 Dec;193(12):883-91 [21713444] J Food Prot. 2012 Jan;75(1):123-31 [22221364] Clin Ther. 2012 Feb;34(2):496-507.e1 [22249106] Emerg Infect Dis. 2012 Mar;18(3):488-92 [22377117] Infect Immun. 1993 Aug;61(8):3392-402 [8335369] Infection. 1993 May-Jun;21(3):140-5 [8365810] J Clin Microbiol. 1996 Feb;34(2):463-5 [8789041] J Infect Dis. 1998 Apr;177(4):962-6 [9534969] Clin Infect Dis. 1999 Nov;29(5):1303-6 [10524979] J Antimicrob Chemother. 2005 Jul;56(1):216-9 [15911552] Infect Immun. 2009 Jul;77(7):2813-23 [19380474] Appl Environ Microbiol. 2012 Jun;78(12):4065-73 [22504816] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/AAC.00763-15 ER - TY - JOUR T1 - Nonsmoker Exposure to Secondhand Cannabis Smoke. III. Oral Fluid and Blood Drug Concentrations and Corresponding Subjective Effects. AN - 1704344178; 26139312 AB - The increasing use of highly potent strains of cannabis prompted this new evaluation of human toxicology and subjective effects following passive exposure to cannabis smoke. The study was designed to produce extreme cannabis smoke exposure conditions tolerable to drug-free nonsmokers. Six experienced cannabis users smoked cannabis cigarettes [5.3% Δ(9)-tetrahydrocannabinol (THC) in Session 1 and 11.3% THC in Sessions 2 and 3] in a closed chamber. Six nonsmokers were seated alternately with smokers during exposure sessions of 1 h duration. Sessions 1 and 2 were conducted with no ventilation and ventilation was employed in Session 3. Oral fluid, whole blood and subjective effect measures were obtained before and at multiple time points after each session. Oral fluid was analyzed by ELISA (4 ng/mL cutoff concentration) and by LC-MS-MS (limit of quantitation) for THC (1 ng/mL) and total THCCOOH (0.02 ng/mL). Blood was analyzed by LC-MS-MS (0.5 ng/mL) for THC, 11-OH-THC and free THCCOOH. Positive tests for THC in oral fluid and blood were obtained for nonsmokers up to 3 h following exposure. Ratings of subjective effects correlated with the degree of exposure. Subjective effect measures and amounts of THC absorbed by nonsmokers (relative to smokers) indicated that extreme secondhand cannabis smoke exposure mimicked, though to a lesser extent, active cannabis smoking. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Journal of analytical toxicology AU - Cone, Edward J AU - Bigelow, George E AU - Herrmann, Evan S AU - Mitchell, John M AU - LoDico, Charles AU - Flegel, Ronald AU - Vandrey, Ryan AD - Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA edwardjcone@gmail.com. ; Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; RTI International, Research Triangle Park, NC, USA. ; Division of Workplace Programs (DWP), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 497 EP - 509 VL - 39 IS - 7 KW - Smoke KW - 0 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Humans KW - Chromatography, Liquid KW - Enzyme-Linked Immunosorbent Assay KW - Tandem Mass Spectrometry KW - Time Factors KW - Risk Assessment KW - Smoke -- adverse effects KW - Air Pollution, Indoor -- adverse effects KW - Dronabinol -- metabolism KW - Affect -- drug effects KW - Marijuana Smoking -- adverse effects KW - Dronabinol -- blood KW - Saliva -- metabolism KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704344178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Nonsmoker+Exposure+to+Secondhand+Cannabis+Smoke.+III.+Oral+Fluid+and+Blood+Drug+Concentrations+and+Corresponding+Subjective+Effects.&rft.au=Cone%2C+Edward+J%3BBigelow%2C+George+E%3BHerrmann%2C+Evan+S%3BMitchell%2C+John+M%3BLoDico%2C+Charles%3BFlegel%2C+Ronald%3BVandrey%2C+Ryan&rft.aulast=Cone&rft.aufirst=Edward&rft.date=2015-09-01&rft.volume=39&rft.issue=7&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbkv070 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-18 N1 - Date created - 2015-08-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Pharmacol Biochem Behav. 1994 Sep;49(1):187-95 [7816872] NIDA Res Monogr. 1990;99:42-62 [2176276] NIDA Res Monogr. 1990;99:121-40 [2176275] J Anal Toxicol. 1996 Oct;20(6):441-52 [8889681] Drugs R D. 2003;4(5):306-9 [12952500] Clin Pharmacokinet. 2003;42(4):327-60 [12648025] J Anal Toxicol. 2001 Jul-Aug;25(5):289-303 [11499881] J Anal Toxicol. 2004 Oct;28(7):546-52 [15516313] J Anal Toxicol. 2005 Oct;29(7):607-15 [16419389] J Anal Toxicol. 2006 Sep;30(7):413-8 [16959132] J Anal Toxicol. 2006 Nov-Dec;30(9):645-50 [17137523] J Anal Toxicol. 2007 May;31(4):187-94 [17555641] J Anal Toxicol. 2007 Jun;31(5):288-93 [17579974] Chem Res Toxicol. 2008 Feb;21(2):494-502 [18062674] J Anal Toxicol. 2008 Oct;32(8):653-8 [19007517] Clin Chem. 2011 Aug;57(8):1127-36 [21677094] Forensic Sci Int. 2011 Oct 10;212(1-3):227-30 [21763088] Clin Chim Acta. 2012 Apr 11;413(7-8):765-70 [22285315] Clin Chem. 2012 Apr;58(4):748-56 [22273566] Drug Alcohol Depend. 2015 Jun 1;151:194-202 [25957157] J Anal Toxicol. 2015 Jan-Feb;39(1):1-12 [25326203] Anal Bioanal Chem. 2013 Oct;405(26):8451-61 [23954944] Clin Pharmacol Ther. 1980 Sep;28(3):409-16 [6250760] J Chromatogr A. 2013 Jul 5;1297:123-30 [23726246] Br J Clin Pharmacol. 2012 Jul;74(1):42-53 [22680341] J Anal Toxicol. 2012 Jul;36(6):413-7 [22532488] Anal Bioanal Chem. 2013 Jul;405(18):6019-27 [23681203] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bkv070 ER - TY - JOUR T1 - Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Levetiracetam. AN - 1704344067; 25663270 AB - Literature and experimental data relevant for the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate release (IR) solid oral dosage forms containing levetiracetam are reviewed. Data on solubility and permeability suggest that levetiracetam belongs to class I of the biopharmaceutical classification system (BCS). Levetiracetam's therapeutic use, its wide therapeutic index, and its favorable pharmacokinetic properties make levetiracetam a valid candidate for the BCS-based biowaiver approach. Further, no BE studies with levetiracetam IR formulations in which the test formulation failed to show BE with the comparator have been reported in the open literature. On the basis of the overall evidence, it appears unlikely that a BCS-based biowaiver approach for levetiracetam IR solid oral dosage forms formulated with established excipients would expose patients to undue risks. Thus, the BCS-based biowaiver approach procedure is recommended for IR solid oral dosage form containing levetiracetam, provided the excipients in the formulation are also present in products that have been approved in countries belonging to or associated with the International Committee on Harmonization and are used in their usual quantities, and provided the dissolution profiles of the test and reference product comply with the current requirements for BCS-based biowaivers. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association. JF - Journal of pharmaceutical sciences AU - Petruševska, Marija AU - Berglez, Sandra AU - Krisch, Igor AU - Legen, Igor AU - Megušar, Klara AU - Peternel, Luka AU - Abrahamsson, Bertil AU - Cristofoletti, Rodrigo AU - Groot, D W AU - Kopp, Sabine AU - Langguth, Peter AU - Mehta, Mehul AU - Polli, James E AU - Shah, Vinod P AU - Dressman, Jennifer AD - Faculty of Medicine, Institute of Preclinical and Clinical Pharmacology & Toxicology, Skopje, Republic of Macedonia. ; SDC Slovenia, Lek Pharmaceuticals d.d., Ljubljana, 1529, Slovenia. ; AstraZeneca Pharmaceutics, R&D, Mölndal, Sweden. ; Brazilian Health Surveillance Agency (Anvisa), Division of Bioequivalence, Brasilia, Brazil. ; RIVM (National Institute for Public Health and the Environment), Bilthoven, The Netherlands. ; World Health Organization, Geneva, Switzerland. ; Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Johannes Gutenberg - University, Mainz, Germany. ; Center for Drug Evaluation and Research, Office of Clinical Pharmacology, US Food and Drug Administration, Maryland. ; Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland. ; International Pharmaceutical Federation (FIP), The Hague, The Netherlands. ; Institute of Pharmaceutical Technology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 2676 EP - 2687 VL - 104 IS - 9 KW - Anticonvulsants KW - 0 KW - Dosage Forms KW - etiracetam KW - 230447L0GL KW - Piracetam KW - ZH516LNZ10 KW - Index Medicus KW - levetiracetam KW - absorption KW - bioequivalence KW - biowaiver KW - biopharmaceutical classification system (BCS) KW - bioavailability KW - solubility KW - pharmacokinetics KW - permeability KW - Therapeutic Equivalency KW - Permeability KW - Animals KW - Chemistry, Pharmaceutical KW - Biopharmaceutics -- classification KW - Humans KW - Biological Availability KW - Piracetam -- pharmacokinetics KW - Piracetam -- analogs & derivatives KW - Anticonvulsants -- pharmacokinetics KW - Piracetam -- administration & dosage KW - Anticonvulsants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704344067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Biowaiver+Monographs+for+Immediate+Release+Solid+Oral+Dosage+Forms%3A+Levetiracetam.&rft.au=Petru%C5%A1evska%2C+Marija%3BBerglez%2C+Sandra%3BKrisch%2C+Igor%3BLegen%2C+Igor%3BMegu%C5%A1ar%2C+Klara%3BPeternel%2C+Luka%3BAbrahamsson%2C+Bertil%3BCristofoletti%2C+Rodrigo%3BGroot%2C+D+W%3BKopp%2C+Sabine%3BLangguth%2C+Peter%3BMehta%2C+Mehul%3BPolli%2C+James+E%3BShah%2C+Vinod+P%3BDressman%2C+Jennifer&rft.aulast=Petru%C5%A1evska&rft.aufirst=Marija&rft.date=2015-09-01&rft.volume=104&rft.issue=9&rft.spage=2676&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=1520-6017&rft_id=info:doi/10.1002%2Fjps.24350 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-10 N1 - Date created - 2015-08-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jps.24350 ER - TY - JOUR T1 - Feasibility Study of a Novel Experimental Induction Protocol Combining B43-PAP (Anti-CD19) Immunotoxin With Standard Induction Chemotherapy in Children and Adolescents With Relapsed B-Lineage ALL: A Report From the Children's Oncology Group. AN - 1703718275; 26261894 AB - B43-pokeweed antiviral protein (B43-PAP) is a high-affinity anti-CD19 immunotoxin that is capable of causing apoptotic death in B-lineage leukemic cells with a drug-resistant phenotype. B43-PAP exhibited in vivo antileukemic activity in preclinical studies as well as on a single-agent phase I clinical trial. This pediatric phase I/II study evaluated the toxicity profile and efficacy of B43-PAP immunotoxin in combination with standard induction chemotherapy in children and adolescents with relapsed CD19-positive B-lineage acute lymphoblastic leukemia (B-ALL). Pharmacokinetic profile and immunogenicity of B43-PAP were assessed. B43-PAP in combination with standard 3 and 4-drug induction chemotherapy was administered on days 9-13 and 21-25 of a 28-day treatment course with vincristine, prednisone, L-asparaginase, daunomycin, and intrathecal methotrexate. Thirty patients with relapsed B-ALL were enrolled on study CCG-0957. Grade III/IV nonhematologic dose-limiting toxicities were encountered in 4 patients evaluable for toxicity and included myalgias, motor dysfunction, pulmonary toxicity, and elevated liver transaminase. Dose-limiting toxicities occurred only with the 4-drug regimen. Fourteen patients achieved a complete remission at the end of induction among the 20 patients evaluable for response. B43-PAP in combination with standard induction chemotherapy can be safely administered and exhibits clinical antileukemic activity against relapsed B-ALL. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Meany, Holly J AU - Seibel, Nita L AU - Krailo, Mark AU - Villaluna, Doojduen AU - Chen, Zhengjia AU - Gaynon, Paul AU - Neglia, Joseph P AU - Park, Julie R AU - Hutchinson, Raymond AU - Sato, Judith K AU - Wells, Robert J AU - Woods, William G AU - Reaman, Gregory AD - *Department of Pediatric Hematology-Oncology, Children's National Medical Center, George Washington University School of Medicine and Public Health, Washington, DC †Clinical Investigations Branch, Cancer Therapy Evaluation Program, NCI, Bethesda ¶¶Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD ‡Keck School of Medicine, University of Southern California ¶Division of Hematology-Oncology, Children's Hospital Los Angeles, Los Angeles §Children's Oncology Group, Arcadia ‡‡Department of Pediatrics, City of Hope National Medical Center, Duarte, CA ∥Department of Biostatistics and Bioinformatics, Emory University ∥∥Aflac Cancer and Blood Disorder Center, Children's Healthcare of Atlanta/Emory University, Atlanta, GA #Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN **Department of Pediatrics, Seattle Children's Hospital, University of Washington, Seattle, WA ††Pediatric Hematology-Oncology, C.S. Mott Children's Hospital, Ann Arbor, MI §§Division of Pediatrics, Children's Cancer Hospital at the University of Texas M.D. Anderson Cancer Center, Houston, TX. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 299 EP - 305 VL - 38 IS - 7 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD19 KW - Antineoplastic Agents KW - Immunotoxins KW - Ribosome Inactivating Proteins, Type 1 KW - pokeweed antiviral protein KW - EC 3.2.2.22 KW - Index Medicus KW - Feasibility Studies KW - Induction Chemotherapy -- methods KW - Humans KW - Drug Therapy, Combination -- methods KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Antibodies, Monoclonal -- immunology KW - Antigens, CD19 -- immunology KW - Immunotoxins -- immunology KW - Ribosome Inactivating Proteins, Type 1 -- immunology KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- immunology KW - B-Lymphocytes -- immunology KW - Antineoplastic Agents -- therapeutic use KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703718275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Feasibility+Study+of+a+Novel+Experimental+Induction+Protocol+Combining+B43-PAP+%28Anti-CD19%29+Immunotoxin+With+Standard+Induction+Chemotherapy+in+Children+and+Adolescents+With+Relapsed+B-Lineage+ALL%3A+A+Report+From+the+Children%27s+Oncology+Group.&rft.au=Meany%2C+Holly+J%3BSeibel%2C+Nita+L%3BKrailo%2C+Mark%3BVillaluna%2C+Doojduen%3BChen%2C+Zhengjia%3BGaynon%2C+Paul%3BNeglia%2C+Joseph+P%3BPark%2C+Julie+R%3BHutchinson%2C+Raymond%3BSato%2C+Judith+K%3BWells%2C+Robert+J%3BWoods%2C+William+G%3BReaman%2C+Gregory&rft.aulast=Meany&rft.aufirst=Holly&rft.date=2015-09-01&rft.volume=38&rft.issue=7&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=1537-4513&rft_id=info:doi/10.1097%2FCJI.0000000000000088 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-04 N1 - Date created - 2015-08-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Oncol. 2005 Nov 1;23(31):7942-50 [16258094] Br J Haematol. 2005 Jul;130(1):67-75 [15982346] Br J Haematol. 2006 Nov;135(4):500-8 [17061978] Blood. 2007 Feb 1;109(3):926-35 [17003380] J Clin Oncol. 2007 Dec 20;25(36):5800-7 [18089878] Br J Haematol. 2000 Mar;108(3):531-43 [10759711] Eur J Haematol. 2015 Feb;94(2):99-108 [24981395] Curr Opin Pediatr. 2008 Feb;20(1):17-22 [18197034] Blood. 2008 Mar 1;111(5):2548-55 [18039957] Leuk Lymphoma. 2008 Jun;49(6):1142-54 [18569638] J Clin Oncol. 2008 Aug 1;26(22):3756-62 [18669463] J Clin Oncol. 2008 Aug 20;26(24):3971-8 [18711187] Lancet Oncol. 2008 Sep;9(9):873-83 [18760243] Cancer Res. 2008 Oct 1;68(19):8049-57 [18829563] Curr Oncol Rep. 2008 Nov;10(6):453-8 [18928659] Pediatr Blood Cancer. 2009 Feb;52(2):177-81 [18816698] Leukemia. 2008 Dec;22(12):2142-50 [18818707] Semin Hematol. 2009 Jan;46(1):52-63 [19100368] J Clin Oncol. 2010 Feb 1;28(4):648-54 [19841326] Curr Opin Oncol. 2013 Nov;25(6):701-6 [24097105] Leuk Lymphoma. 2014 Apr;55(4):737-48 [23841506] N Engl J Med. 2014 Oct 16;371(16):1507-17 [25317870] Clin Cancer Res. 1999 Dec;5(12):3906-13 [10632319] Clin Cancer Res. 1999 Dec;5(12):3920-7 [10632321] Br J Haematol. 2003 Nov;123(3):396-405 [14616997] Blood. 2004 Jul 1;104(1):178-83 [15001473] J Exp Med. 1986 Feb 1;163(2):347-68 [3511171] Blood. 1988 Jan;71(1):13-29 [3257143] Blood. 1990 Nov 15;76(10):1908-23 [2242419] J Immunol Methods. 1991 Feb 15;136(2):221-37 [1705571] Blood. 1991 Sep 1;78(5):1166-72 [1878583] Blood. 1992 May 15;79(10):2649-61 [1375109] Blood. 1993 Feb 1;81(3):602-9 [8427957] Br J Haematol. 1993 Nov;85(3):435-8 [8136262] Blood. 1995 Dec 1;86(11):4228-33 [7492781] Leuk Lymphoma. 1995 Aug;18(5-6):385-97 [8528044] Haematologica. 1995 Nov-Dec;80(6):546-56 [8647523] J Clin Oncol. 1999 Feb;17(2):445-55 [10080584] Leuk Lymphoma. 1999 Mar;33(1-2):101-6 [10194126] Cancer. 2005 Jan 15;103(2):368-76 [15599932] J Clin Oncol. 2006 Jul 1;24(19):3150-6 [16717292] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/CJI.0000000000000088 ER - TY - JOUR T1 - Mother's education and the risk of preterm and small for gestational age birth: a DRIVERS meta-analysis of 12 European cohorts. AN - 1703717528; 25911693 AB - A healthy start to life is a major priority in efforts to reduce health inequalities across Europe, with important implications for the health of future generations. There is limited combined evidence on inequalities in health among newborns across a range of European countries. Prospective cohort data of 75 296 newborns from 12 European countries were used. Maternal education, preterm and small for gestational age births were determined at baseline along with covariate data. Regression models were estimated within each cohort and meta-analyses were conducted to compare and measure heterogeneity between cohorts. Mother's education was linked to an appreciable risk of preterm and small for gestational age (SGA) births across 12 European countries. The excess risk of preterm births associated with low maternal education was 1.48 (1.29 to 1.69) and 1.84 (0.99 to 2.69) in relative and absolute terms (Relative/Slope Index of Inequality, RII/SII) for all cohorts combined. Similar effects were found for SGA births, but absolute inequalities were greater, with an SII score of 3.64 (1.74 to 5.54). Inequalities at birth were strong in the Netherlands, the UK, Sweden and Spain and marginal in other countries studied. This study highlights the value of comparative cohort analysis to better understand the relationship between maternal education and markers of fetal growth in different settings across Europe. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Journal of epidemiology and community health AU - Ruiz, Milagros AU - Goldblatt, Peter AU - Morrison, Joana AU - Kukla, Lubomír AU - Švancara, Jan AU - Riitta-Järvelin, Marjo AU - Taanila, Anja AU - Saurel-Cubizolles, Marie-Josèphe AU - Lioret, Sandrine AU - Bakoula, Chryssa AU - Veltsista, Alexandra AU - Porta, Daniela AU - Forastiere, Francesco AU - van Eijsden, Manon AU - Vrijkotte, Tanja G M AU - Eggesbø, Merete AU - White, Richard A AU - Barros, Henrique AU - Correia, Sofia AU - Vrijheid, Martine AU - Torrent, Maties AU - Rebagliato, Marisa AU - Larrañaga, Isabel AU - Ludvigsson, Johnny AU - Olsen Faresjö, Åshild AU - Hryhorczuk, Daniel AU - Antipkin, Youriy AU - Marmot, Michael AU - Pikhart, Hynek AD - Research Department of Epidemiology and Public Health, University College London, London, UK. ; Research Department of Epidemiology and Public Health, UCL Institute of Health Equity, University College London, London, UK. ; Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Brno, Czech Republic. ; Faculty of Science, Research Centre for Toxic Compounds in the Environment (RECETOX), Masaryk University, Brno, Czech Republic Faculty of Medicine, Institute of Biostatistics and Analyses, Masaryk University, Brno, Czech Republic. ; Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE), Centre for Environment and Health, School of Public Health, Imperial College London, London, UK Unit of Primary Care, Oulu University Hospital, Oulu, Finland Center for Life Course Epidemiology, Faculty of Medicine, University of Oulu, Oulu, Finland Institute of Health Sciences, University of Oulu, Oulu, Finland. ; Biocenter Oulu, University of Oulu, Oulu, Finland. ; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics, Sorbonne Paris Cité, DHU Risks in Pregnancy, Paris Descartes University, Paris, France. ; Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1153, Early Origin of the Child's Health and Development Team (ORCHAD), Center for Epidemiology and Statistics, Sorbonne Paris Cité, Paris Descartes University, Paris, France. ; First Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece. ; Department of Epidemiology of the Lazio Regional Health System, Rome, Italy. ; Department of Epidemiology and Health Promotion, Public Health Service of Amsterdam, Amsterdam, The Netherlands. ; Department of Public Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. ; Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway. ; Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal EPIUnit - Institute of Public Health, University of Porto, Porto, Portugal. ; Center for Research in Environmental Epidemiology (CREAL), Barcelona, Spain Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain. ; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain IB-Salut Menorca Health Area, Balearic Islands, Spain. ; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Barcelona, Spain Departamento de Medicina, Universitat Jaume I, Castellon, Spain. ; Public Health Department of Gipuzkoa, Gipuzkoa, Spain BIODONOSTIA Health Research Institute, San Sebastian, Spain. ; Division of Pediatrics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. ; Department of Medicine and Health Sciences, Linköping University, Linköping, Sweden. ; Center for Global Health, University of Illinois College of Medicine, Chicago, Illinois, USA. ; Institute of Pediatrics, Obstetrics, and Gynecology, Kyiv, Ukraine. ; Research Department of Epidemiology and Public Health, University College London, London, UK Research Department of Epidemiology and Public Health, UCL Institute of Health Equity, University College London, London, UK. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 826 EP - 833 VL - 69 IS - 9 KW - Index Medicus KW - INEQUALITIES KW - EPIDEMIOLOGY KW - CHILD HEALTH KW - Regression Analysis KW - Educational Status KW - Prospective Studies KW - Risk Factors KW - Humans KW - Linear Models KW - Cross-Cultural Comparison KW - Infant, Newborn KW - Europe -- epidemiology KW - Male KW - Female KW - Pregnancy KW - Pregnancy Outcome -- epidemiology KW - Mothers -- statistics & numerical data KW - Premature Birth -- epidemiology KW - Infant, Small for Gestational Age UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703717528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+epidemiology+and+community+health&rft.atitle=Mother%27s+education+and+the+risk+of+preterm+and+small+for+gestational+age+birth%3A+a+DRIVERS+meta-analysis+of+12+European+cohorts.&rft.au=Ruiz%2C+Milagros%3BGoldblatt%2C+Peter%3BMorrison%2C+Joana%3BKukla%2C+Lubom%C3%ADr%3B%C5%A0vancara%2C+Jan%3BRiitta-J%C3%A4rvelin%2C+Marjo%3BTaanila%2C+Anja%3BSaurel-Cubizolles%2C+Marie-Jos%C3%A8phe%3BLioret%2C+Sandrine%3BBakoula%2C+Chryssa%3BVeltsista%2C+Alexandra%3BPorta%2C+Daniela%3BForastiere%2C+Francesco%3Bvan+Eijsden%2C+Manon%3BVrijkotte%2C+Tanja+G+M%3BEggesb%C3%B8%2C+Merete%3BWhite%2C+Richard+A%3BBarros%2C+Henrique%3BCorreia%2C+Sofia%3BVrijheid%2C+Martine%3BTorrent%2C+Maties%3BRebagliato%2C+Marisa%3BLarra%C3%B1aga%2C+Isabel%3BLudvigsson%2C+Johnny%3BOlsen+Faresj%C3%B6%2C+%C3%85shild%3BHryhorczuk%2C+Daniel%3BAntipkin%2C+Youriy%3BMarmot%2C+Michael%3BPikhart%2C+Hynek&rft.aulast=Ruiz&rft.aufirst=Milagros&rft.date=2015-09-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=143rd+American+Public+Health+Association+Annual+Meeting+and+Exposition+%28APHA+2015%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-13 N1 - Date created - 2015-08-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Pediatr Res. 2014 Nov;76(5):418-24 [25122581] Eur J Obstet Gynecol Reprod Biol. 2003 Nov 28;111 Suppl 1:S33-44 [14642318] Cent Eur J Public Health. 2004 Sep;12(3):157-60 [15508415] Paediatr Perinat Epidemiol. 1987 Apr;1(1):43-55 [3506190] Lancet. 1993 Apr 10;341(8850):938-41 [8096277] Am J Public Health. 1994 Jun;84(6):932-7 [8203689] Obstet Gynecol. 1996 Feb;87(2):163-8 [8559516] J Health Soc Behav. 1996 Mar;37(1):104-20 [8820314] Soc Sci Med. 1997 Mar;44(6):757-71 [9080560] Paediatr Perinat Epidemiol. 1997 Jul;11(3):298-312 [9246691] Dev Med Child Neurol. 2006 Nov;48(11):906-12 [17044959] Epidemiol Prev. 2007 Nov-Dec;31(6):303-8 [18326421] N Engl J Med. 2008 Jul 3;359(1):61-73 [18596274] BMC Pediatr. 2008;8:42 [18844983] Lancet. 2008 Nov 8;372(9650):1661-9 [18994664] Br J Nutr. 2009 Feb;101(4):583-91 [18631416] Public Health Nutr. 2009 Jul;12(7):922-31 [18752697] Environ Res. 2009 Jul;109(5):559-66 [19410245] Heart. 2009 Dec;95(24):2014-22 [19822574] Bull World Health Organ. 2010 Jan;88(1):31-8 [20428351] Eur Respir J. 2001 Aug;18(2):323-9 [11529291] Int J Epidemiol. 2012 Aug;41(4):930-40 [21471022] J Child Neurol. 2011 Feb;26(2):199-204 [20921568] Int J Epidemiol. 2011 Oct;40(5):1176-86 [20813863] Comment In: J Epidemiol Community Health. 2015 Sep;69(9):821-2 [25858637] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/jech-2014-205387 ER - TY - CONF T1 - Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute. AN - 1703245099; 26134581 AB - Recent technological advances have led to rapid progress in the characterization of epigenetic modifications that control gene expression in a generally heritable way, and are likely involved in defining cellular phenotypes, developmental stages and disease status from one generation to the next. On November 18, 2013, the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) held a symposium entitled "Advances in Assessing Adverse Epigenetic Effects of Drugs and Chemicals" in Washington, D.C. The goal of the symposium was to identify gaps in knowledge and highlight promising areas of progress that represent opportunities to utilize epigenomic profiling for risk assessment of drugs and chemicals. Epigenomic profiling has the potential to provide mechanistic information in toxicological safety assessments; this is especially relevant for the evaluation of carcinogenic or teratogenic potential and also for drugs that directly target epigenetic modifiers, like DNA methyltransferases or histone modifying enzymes. Furthermore, it can serve as an endpoint or marker for hazard characterization in chemical safety assessment. The assessment of epigenetic effects may also be approached with new model systems that could directly assess transgenerational effects or potentially sensitive stem cell populations. These would enhance the range of safety assessment tools for evaluating xenobiotics that perturb the epigenome. Here we provide a brief synopsis of the symposium, update findings since that time and then highlight potential directions for future collaborative efforts to incorporate epigenetic profiling into risk assessment. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology AU - Miousse, Isabelle R AU - Currie, Richard AU - Datta, Kaushik AU - Ellinger-Ziegelbauer, Heidrun AU - French, John E AU - Harrill, Alison H AU - Koturbash, Igor AU - Lawton, Michael AU - Mann, Derek AU - Meehan, Richard R AU - Moggs, Jonathan G AU - O'Lone, Raegan AU - Rasoulpour, Reza J AU - Pera, Renee A Reijo AU - Thompson, Karol Y1 - 2015/09/01/ PY - 2015 DA - 2015 Sep 01 SP - 11 EP - 19 VL - 335 KW - Genetic Markers KW - 0 KW - Index Medicus KW - Stem cells KW - Transgenerational effects KW - Epigenetics KW - Biomarkers KW - Safety assessment KW - Models KW - Stem Cells -- drug effects KW - Animals KW - Cellular Reprogramming -- drug effects KW - Endpoint Determination KW - Dose-Response Relationship, Drug KW - Humans KW - DNA Methylation -- drug effects KW - Stem Cells -- pathology KW - Environmental Monitoring -- standards KW - Gene Expression Regulation, Developmental -- drug effects KW - Risk Assessment KW - Epigenesis, Genetic -- drug effects KW - Toxicity Tests -- standards KW - Gene Expression Profiling -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703245099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Toxicology&rft.atitle=Importance+of+investigating+epigenetic+alterations+for+industry+and+regulators%3A+An+appraisal+of+current+efforts+by+the+Health+and+Environmental+Sciences+Institute.&rft.au=Miousse%2C+Isabelle+R%3BCurrie%2C+Richard%3BDatta%2C+Kaushik%3BEllinger-Ziegelbauer%2C+Heidrun%3BFrench%2C+John+E%3BHarrill%2C+Alison+H%3BKoturbash%2C+Igor%3BLawton%2C+Michael%3BMann%2C+Derek%3BMeehan%2C+Richard+R%3BMoggs%2C+Jonathan+G%3BO%27Lone%2C+Raegan%3BRasoulpour%2C+Reza+J%3BPera%2C+Renee+A+Reijo%3BThompson%2C+Karol&rft.aulast=Miousse&rft.aufirst=Isabelle&rft.date=2015-09-01&rft.volume=335&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.06.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-28 N1 - Date created - 2015-08-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.06.009 ER - TY - JOUR T1 - Targeting of IL-4 and IL-13 receptors for cancer therapy. AN - 1703239604; 26088753 AB - The Th2 cytokines, interleukin (IL)-4 and -13, are structurally and functionally related. They regulate immune responses and the immune microenvironment, not only under normal physiological conditions, but also in cancer. Both cytokines bind to their high-affinity receptors and form various configurations of receptor subtypes. We and others have reported that IL-4 and IL-13 bind to IL-4Rα and IL-13Rα1 chains, forming functional receptors in cancer cells. IL-13 also binds with high affinity to a private chain IL-13Rα2. After forming ligand-receptor complexes, both cytokines initiate signal transduction and mediate biological effects, such as tumor proliferation, cell survival, cell adhesion and metastasis. In certain cancers, the presence of these cytokine receptors may serve as biomarkers of cancer aggressiveness. In a series of studies, we reported that overexpression of IL-4 and IL-13 receptors on cancer cells provides targets for therapeutic agents for cancer therapy. In addition, both of these cytokines and their receptors have been shown to play important roles in modulating the immune system for tumor growth. IL-4, IL-13 and their receptors seem to play a role in cancer stem cells and provide unique targets to eradicate these cells. In this review article, we summarize some of the important attributes of IL-4 and IL-13 receptors in cancer biology and discuss pre-clinical and clinical studies pertaining to recombinant immunotoxins designed to target these receptors. Published by Elsevier Ltd. JF - Cytokine AU - Suzuki, Akiko AU - Leland, Pamela AU - Joshi, Bharat H AU - Puri, Raj K AD - Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States. Electronic address: akiko.suzuki@fda.hhs.gov. ; Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States. Electronic address: pamela.dover@fda.hhs.gov. ; Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States. Electronic address: bharat.joshi@fda.hhs.gov. ; Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, United States. Electronic address: raj.puri@fda.hhs.gov. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 79 EP - 88 VL - 75 IS - 1 KW - Antibodies, Monoclonal KW - 0 KW - Antigens KW - Antineoplastic Agents KW - Biomarkers, Tumor KW - IL4R protein, human KW - Immunotoxins KW - Interleukin-13 Receptor alpha2 Subunit KW - Interleukin-4 Receptor alpha Subunit KW - Receptors, Interleukin-13 KW - interleukin-13 receptor, human KW - liposomal doxorubicin KW - Polyethylene Glycols KW - 30IQX730WE KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Interleukin-13 KW - Receptor-targeted cancer therapy KW - Interleukin-4 KW - Interleukin-13 receptor KW - Interleukin-4 receptor KW - Animals KW - Doxorubicin -- analogs & derivatives KW - Doxorubicin -- chemistry KW - Humans KW - Disease Models, Animal KW - Mice KW - Cell Proliferation KW - Antibodies, Monoclonal -- immunology KW - Cell Survival KW - Immunotherapy -- methods KW - Immunotoxins -- chemistry KW - Biomarkers, Tumor -- metabolism KW - Interleukin-13 Receptor alpha2 Subunit -- metabolism KW - Polyethylene Glycols -- chemistry KW - Neoplasm Metastasis KW - Antigens -- immunology KW - Cell Adhesion KW - Gene Expression Regulation, Neoplastic KW - Receptors, Interleukin-13 -- metabolism KW - Interleukin-4 Receptor alpha Subunit -- metabolism KW - Antineoplastic Agents -- therapeutic use KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703239604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytokine&rft.atitle=Targeting+of+IL-4+and+IL-13+receptors+for+cancer+therapy.&rft.au=Suzuki%2C+Akiko%3BLeland%2C+Pamela%3BJoshi%2C+Bharat+H%3BPuri%2C+Raj+K&rft.aulast=Suzuki&rft.aufirst=Akiko&rft.date=2015-09-01&rft.volume=75&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Cytokine&rft.issn=1096-0023&rft_id=info:doi/10.1016%2Fj.cyto.2015.05.026 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-06 N1 - Date created - 2015-08-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cyto.2015.05.026 ER - TY - JOUR T1 - Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles. AN - 1700106209; 26217770 AB - High mortality rates are associated with the life threatening disease of sepsis. Improvements in septic patient survivability have failed to materialize with currently available treatments. This article represents data regarding a study published in biomaterials (Vellaisamy et al., Biomaterials, 2015, in press). with the purpose of evaluating whether severe sepsis mortality and associated hepatic dysfunction induced by lipopolysaccharide (LPS) can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the method and processing of raw data related to our study publish in Biomaterials and Data in Brief (Vellaisamy et al., Biomaterials, 2015, in press; Vellaisamy et al., Data in Brief, 2015, in press.). The data contained in this article evaluates the contribution of MAPK signaling in LPS induced sepsis. Macrophage cells (RAW 264.7) were treated with a range of cerium oxide nanoparticle concentration in the presence and absence of LPS. Immunoblotting was performed on the cell lysates to evaluate the effect of cerium oxide nanoparticle treatment on LPS induced changes in Mitogen Activated Protein Kinases (MAPK) p-38, ERK 1/2, and SAPK/JNK phosphorylation. JF - Data in brief AU - Selvaraj, Vellaisamy AU - Nepal, Niraj AU - Rogers, Steven AU - Manne, Nandini D P K AU - Arvapalli, Ravikumar AU - Rice, Kevin M AU - Asano, Shinichi AU - Fankenhanel, Erin AU - Ma, J Y AU - Shokuhfar, Tolou AU - Maheshwari, Mani AU - Blough, Eric R AD - Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA. ; Health Effects Laboratory Division, NIOSH, Morgantown, WV, USA. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, USA. ; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA ; Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA ; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA ; Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 96 EP - 99 VL - 4 KW - MAPK KW - Sepsis KW - Raw 264.7 cells KW - LPS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700106209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Data+in+brief&rft.atitle=Lipopolysaccharide+induced+MAP+kinase+activation+in+RAW+264.7+cells+attenuated+by+cerium+oxide+nanoparticles.&rft.au=Selvaraj%2C+Vellaisamy%3BNepal%2C+Niraj%3BRogers%2C+Steven%3BManne%2C+Nandini+D+P+K%3BArvapalli%2C+Ravikumar%3BRice%2C+Kevin+M%3BAsano%2C+Shinichi%3BFankenhanel%2C+Erin%3BMa%2C+J+Y%3BShokuhfar%2C+Tolou%3BMaheshwari%2C+Mani%3BBlough%2C+Eric+R&rft.aulast=Selvaraj&rft.aufirst=Vellaisamy&rft.date=2015-09-01&rft.volume=4&rft.issue=&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Data+in+brief&rft.issn=&rft_id=info:doi/10.1016%2Fj.dib.2015.04.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-28 N1 - Date created - 2015-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.dib.2015.04.022 ER - TY - JOUR T1 - Cerium oxide nanoparticles inhibit lipopolysaccharide induced MAP kinase/NF-kB mediated severe sepsis. AN - 1700104821; 26217772 AB - The life threatening disease of sepsis is associated with high mortality. Septic patient survivability with currently available treatments has failed to improve. The purpose of this study was to evaluate whether lipopolysaccharide (LPS) induced sepsis mortality and associated hepatic dysfunction can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the methods processing of raw data related to our study published in Biomaterials (Selvaraj et al., Biomaterials, 2015, In press) and Data in Brief (Selvaraj et al., Data in Brief, 2015, In Press). The data present here provides confirmation of cerium oxide nanoparticle treatments ability to prevent the LPS induced sepsis associated changes in physiological, blood cell count, inflammatory protein and growth factors in vivo. In vitro assays investigation the treated of macrophages cells with different concentrations of cerium oxide nanoparticle demonstrate that concentration of cerium oxide nanoparticles below 1 µg/ml did not significantly influence cell survival as determined by the MTT assay. JF - Data in brief AU - Selvaraj, Vellaisamy AU - Nepal, Niraj AU - Rogers, Steven AU - Manne, Nandini D P K AU - Arvapalli, Ravikumar AU - Rice, Kevin M AU - Asano, Shinichi AU - Fankenhanel, Erin AU - Ma, J Y AU - Shokuhfar, Tolou AU - Maheshwari, Mani AU - Blough, Eric R AD - Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA. ; Health Effects Laboratory Division, NIOSH, Morgantown, WV, USA. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, USA. ; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA ; Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA ; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA ; Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 105 EP - 115 VL - 4 KW - MTT KW - Sepsis KW - LPS KW - Sprague Dawley rat KW - Raw 264.7 KW - Cerium oxide nanoparticles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700104821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Data+in+brief&rft.atitle=Cerium+oxide+nanoparticles+inhibit+lipopolysaccharide+induced+MAP+kinase%2FNF-kB+mediated+severe+sepsis.&rft.au=Selvaraj%2C+Vellaisamy%3BNepal%2C+Niraj%3BRogers%2C+Steven%3BManne%2C+Nandini+D+P+K%3BArvapalli%2C+Ravikumar%3BRice%2C+Kevin+M%3BAsano%2C+Shinichi%3BFankenhanel%2C+Erin%3BMa%2C+J+Y%3BShokuhfar%2C+Tolou%3BMaheshwari%2C+Mani%3BBlough%2C+Eric+R&rft.aulast=Selvaraj&rft.aufirst=Vellaisamy&rft.date=2015-09-01&rft.volume=4&rft.issue=&rft.spage=105&rft.isbn=&rft.btitle=&rft.title=Data+in+brief&rft.issn=&rft_id=info:doi/10.1016%2Fj.dib.2015.04.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-28 N1 - Date created - 2015-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.dib.2015.04.023 ER - TY - JOUR T1 - 24-hour human urine and serum profiles of bisphenol A following ingestion in soup: Individual pharmacokinetic data and emographics. AN - 1700104724; 26217767 AB - Here we present data to evaluate potential absorption of Bisphenol A through non-metabolizing tissues of the upper digestive tract. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a 24 h period in 10 adult male volunteers following ingestion of 30 μg d6-BPA/kg body weight in soup. The pharmacokinetic behavior of BPA and its metabolites in this cohort (rapid absorption, complete elimination, evidence against sublingual absorption) was reported. This Data in Brief article contains the corresponding individual pharmacokinetic data, reports the demographics of the cohort and provides additional details related to the analytical methods employed and is related to [4]. JF - Data in brief AU - Teeguarden, Justin G AU - Twaddle, Nathan C AU - Churchwell, Mona I AU - Yang, Xiaoxia AU - Fisher, Jeffrey W AU - Seryak, Liesel M AU - Doerge, Daniel R AD - Health Effects and Exposure Science, Pacific Northwest National Laboratory, Richland, WA 99352, USA ; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 93771, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH 43210, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 83 EP - 86 VL - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700104724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+research+and+human+retroviruses&rft.atitle=A+Phase+1+Randomized%2C+Blinded+Comparison+of+the+Pharmacokinetics+and+Colonic+Distribution+of+Three+Candidate+Rectal+Microbicide+Formulations+of+Tenofovir+1%25+Gel+with+Simulated+Unprotected+Sex+%28CHARM-02%29.&rft.au=Hiruy%2C+Hiwot%3BFuchs%2C+Edward+J%3BMarzinke%2C+Mark+A%3BBakshi%2C+Rahul+P%3BBreakey%2C+Jennifer+C%3BAung%2C+Wutyi+S%3BManohar%2C+Madhuri%3BYue%2C+Chen%3BCaffo%2C+Brian+S%3BDu%2C+Yong%3BAbebe%2C+Kaleab+Z%3BSpiegel%2C+Hans+M+L%3BRohan%2C+Lisa+C%3BMcGowan%2C+Ian%3BHendrix%2C+Craig+W&rft.aulast=Hiruy&rft.aufirst=Hiwot&rft.date=2015-11-01&rft.volume=31&rft.issue=11&rft.spage=1098&rft.isbn=&rft.btitle=&rft.title=AIDS+research+and+human+retroviruses&rft.issn=1931-8405&rft_id=info:doi/10.1089%2FAID.2015.0098 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-28 N1 - Date created - 2015-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.dib.2015.03.002 ER - TY - JOUR T1 - Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation. AN - 1700104641; 26217789 AB - Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro model based on the differentiation of mouse embryonic stem cells (mESCs), and published the major findings in a research article entitled "Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells" [1]. The data presented herein contains complementary information related to the aforementioned research article. JF - Data in brief AU - Gao, Xiugong AU - Sprando, Robert L AU - Yourick, Jeffrey J AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, USA. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 199 EP - 202 VL - 4 KW - Differentiation KW - Microarray KW - Transcriptomics KW - Thalidomide KW - Developmental toxicity KW - Mouse KW - Embryonic stem cell UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700104641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Data+in+brief&rft.atitle=Transcriptomic+changes+in+mouse+embryonic+stem+cells+exposed+to+thalidomide+during+spontaneous+differentiation.&rft.au=Gao%2C+Xiugong%3BSprando%2C+Robert+L%3BYourick%2C+Jeffrey+J&rft.aulast=Gao&rft.aufirst=Xiugong&rft.date=2015-09-01&rft.volume=4&rft.issue=&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Data+in+brief&rft.issn=&rft_id=info:doi/10.1016%2Fj.dib.2015.05.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-28 N1 - Date created - 2015-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.dib.2015.05.014 ER - TY - JOUR T1 - Mammalian gastrointestinal tract parameters modulating the integrity, surface properties, and absorption of food-relevant nanomaterials. AN - 1698967798; 25641962 AB - Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid-based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food-relevant engineered NMs for risk assessment. © 2015 The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley Periodicals, Inc. JF - Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology AU - Bellmann, Susann AU - Carlander, David AU - Fasano, Alessio AU - Momcilovic, Dragan AU - Scimeca, Joseph A AU - Waldman, W James AU - Gombau, Lourdes AU - Tsytsikova, Lyubov AU - Canady, Richard AU - Pereira, Dora I A AU - Lefebvre, David E AD - TNO, Utrecht, The Netherlands. ; Nanotechnology Industries Association, Brussels, Belgium. ; Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA, USA. ; Department of Health and Human Services, US Food and Drug Administration, Silver Spring, MD, USA. ; Cargill, Incorporated, Minneapolis, MN, USA. ; Ohio State University, Columbus, OH, USA. ; Leitat Technological Center, Barcelona, Spain. ; Center for Risk Science Innovation and Application, ILSI Research Foundation, Washington, DC, USA. ; MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK. ; Regulatory Toxicology Research Division, Food Directorate, Health Canada, Ottawa, Canada. PY - 2015 SP - 609 EP - 622 VL - 7 IS - 5 KW - Index Medicus KW - Animals KW - Humans KW - Surface Properties KW - Gastrointestinal Tract -- physiology KW - Nanostructures -- chemistry KW - Food KW - Mammals -- physiology KW - Intestinal Absorption UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698967798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.atitle=Mammalian+gastrointestinal+tract+parameters+modulating+the+integrity%2C+surface+properties%2C+and+absorption+of+food-relevant+nanomaterials.&rft.au=Bellmann%2C+Susann%3BCarlander%2C+David%3BFasano%2C+Alessio%3BMomcilovic%2C+Dragan%3BScimeca%2C+Joseph+A%3BWaldman%2C+W+James%3BGombau%2C+Lourdes%3BTsytsikova%2C+Lyubov%3BCanady%2C+Richard%3BPereira%2C+Dora+I+A%3BLefebvre%2C+David+E&rft.aulast=Bellmann&rft.aufirst=Susann&rft.date=2015-09-01&rft.volume=7&rft.issue=5&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Wiley+interdisciplinary+reviews.+Nanomedicine+and+nanobiotechnology&rft.issn=1939-0041&rft_id=info:doi/10.1002%2Fwnan.1333 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-25 N1 - Date created - 2015-07-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/wnan.1333 ER - TY - JOUR T1 - Identification of pathway-based toxicity in the BALB/c 3T3 cell model. AN - 1689623569; 25450744 AB - The particulate matter represents one of the most complex environmental mixtures, whose effects on human health and environment vary according to particles characteristics and source of emissions. The present study describes an integrated approach, including in vitro tests and toxicogenomics, to highlight the effects of air particulate matter on toxicological relevant endpoints. Air samples (PM2.5) were collected in summer and winter at different sites, representative of different levels of air pollution. Samples organic extracts were tested in the BALB/c 3T3 CTA at a dose range 1-12m(3). The effect of the exposure to the samples at a dose of 8m(3) on the whole-genome transcriptomic profile was also assessed. All the collected samples induced dose-related toxic effects in the exposed cells. The modulated gene pathways confirmed that toxicity was related to sampling season and sampling site. The analysis of the KEGG's pathways showed modulation of several gene networks related to oxidative stress and inflammation. Even if the samples did not induce cell transformation in the treated cells, gene pathways related to the onset of cancer were modulated as a consequence of the exposure. This integrated approach could provide valuable information for predicting toxic risks in humans exposed to air pollution. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Vaccari, Monica AU - Mascolo, Maria Grazia AU - Rotondo, Francesca AU - Morandi, Elena AU - Quercioli, Daniele AU - Perdichizzi, Stefania AU - Zanzi, Cristina AU - Serra, Stefania AU - Poluzzi, Vanes AU - Angelini, Paola AU - Grilli, Sandro AU - Colacci, Annamaria AD - Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy. Electronic address: monica.vaccari4@unibo.it. ; Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy. ; Center for Environmental Toxicology, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy; Interdepartmental Center for Cancer Research "G. Prodi", University of Bologna, Italy. ; Department of Experimental, Diagnostic and Specialty Medicine-Cancer Research Section, University of Bologna, Italy. ; Center for Urban Areas, Environmental Protection and Health Prevention Agency - Emilia-Romagna Region (ER-EPA), Bologna, Italy. ; Public Health Service, Emilia-Romagna Region, Bologna, Italy. Y1 - 2015/09// PY - 2015 DA - September 2015 SP - 1240 EP - 1253 VL - 29 IS - 6 KW - Air Pollutants KW - 0 KW - Particulate Matter KW - Index Medicus KW - Gene expression KW - Pathway-based toxicity KW - Environmental mixtures KW - Particulate matter KW - Cell transformation assay KW - Gene Expression -- drug effects KW - Gene Expression Profiling KW - Animals KW - Cell Survival -- drug effects KW - BALB 3T3 Cells KW - Microarray Analysis KW - Mice KW - Particulate Matter -- toxicity KW - Air Pollutants -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689623569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Identification+of+pathway-based+toxicity+in+the+BALB%2Fc+3T3+cell+model.&rft.au=Vaccari%2C+Monica%3BMascolo%2C+Maria+Grazia%3BRotondo%2C+Francesca%3BMorandi%2C+Elena%3BQuercioli%2C+Daniele%3BPerdichizzi%2C+Stefania%3BZanzi%2C+Cristina%3BSerra%2C+Stefania%3BPoluzzi%2C+Vanes%3BAngelini%2C+Paola%3BGrilli%2C+Sandro%3BColacci%2C+Annamaria&rft.aulast=Vaccari&rft.aufirst=Monica&rft.date=2015-09-01&rft.volume=29&rft.issue=6&rft.spage=1240&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2014.10.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-07 N1 - Date created - 2015-06-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2014.10.002 ER - TY - JOUR T1 - Inhibition of prolactin with bromocriptine for 28days increases blood-brain barrier permeability in the rat. AN - 1697211634; 26047726 AB - The blood-brain barrier (BBB) is necessary for the proper function of the brain. Its maintenance is regulated by endogenous factors. Recent evidences suggest prolactin (PRL) regulates the BBB properties in vitro, nevertheless no evidence of these effects have been reported in vivo. The aim of this study was to evaluate the role of PRL in the maintenance of the BBB in the rat. Male Wistar rats were treated with Bromocriptine (Bromo) to inhibit PRL production for 28days in the absence or presence of lipopolysaccharide (LPS). BBB permeability was evaluated through the Evans Blue dye and fluorescein-dextran extravasation as well as through edema formation. The expression of claudin-5, occludin, glial fibrillary acidic protein (GFAP) and the PRL receptor (PRLR) was evaluated through western blot. Bromo reduced the physiological levels of PRL at 28days. At the same time, Bromo increased BBB permeability and edema formation associated with a decrement in claudin-5 and occludin and potentiated the increase in BBB permeability induced by LPS. However, no neuroinflammation was detected, since the expression of GFAP was unchanged, as well as the expression of the PRLR. These data provide the first evidence that inhibition of PRL with Bromo affects the maintenance of the BBB through modulating the expression of tight junction proteins in vivo. Copyright © 2015 IBRO. All rights reserved. JF - Neuroscience AU - Rosas-Hernandez, H AU - Ramirez, M AU - Ramirez-Lee, M A AU - Ali, S F AU - Gonzalez, C AD - Laboratorio de Fisiologia Celular, Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava 6, Colonia Universitaria, San Luis Potosi, SLP 78210, Mexico. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Laboratorio de Fisiologia Celular, Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava 6, Colonia Universitaria, San Luis Potosi, SLP 78210, Mexico. Electronic address: cgonzalez.uaslp@gmail.com. Y1 - 2015/08/20/ PY - 2015 DA - 2015 Aug 20 SP - 61 EP - 70 VL - 301 KW - Claudin-5 KW - 0 KW - Cldn5 protein, rat KW - Dopamine Agonists KW - Hormone Antagonists KW - Occludin KW - Ocln protein, rat KW - Bromocriptine KW - 3A64E3G5ZO KW - Prolactin KW - 9002-62-4 KW - Index Medicus KW - blood–brain barrier KW - prolactin KW - lipopolysaccharide KW - tight junctions KW - permeability KW - Rats KW - Animals KW - Brain Edema -- metabolism KW - Dopamine Agonists -- pharmacology KW - Claudin-5 -- metabolism KW - Rats, Wistar KW - Bromocriptine -- pharmacology KW - Occludin -- metabolism KW - Male KW - Hormone Antagonists -- pharmacology KW - Blood-Brain Barrier -- metabolism KW - Capillary Permeability KW - Prolactin -- antagonists & inhibitors KW - Prolactin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697211634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Inhibition+of+prolactin+with+bromocriptine+for+28days+increases+blood-brain+barrier+permeability+in+the+rat.&rft.au=Rosas-Hernandez%2C+H%3BRamirez%2C+M%3BRamirez-Lee%2C+M+A%3BAli%2C+S+F%3BGonzalez%2C+C&rft.aulast=Rosas-Hernandez&rft.aufirst=H&rft.date=2015-08-20&rft.volume=301&rft.issue=&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=1873-7544&rft_id=info:doi/10.1016%2Fj.neuroscience.2015.05.066 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-18 N1 - Date created - 2015-07-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuroscience.2015.05.066 ER - TY - JOUR T1 - FDA Approval: Ibrutinib for Patients with Previously Treated Mantle Cell Lymphoma and Previously Treated Chronic Lymphocytic Leukemia AN - 1808618284; PQ0003450511 AB - On November 13, 2013, the FDA granted accelerated approval to ibrutinib (IMBRUVICA capsules; Pharmacyclics, Inc.) for the treatment of patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. On February 12, 2014, the FDA granted accelerated approval for the treatment of patients with chronic lymphocytic leukemia (CLL) who have received at least one prior therapy. Ibrutinib is a first-in-class Bruton's tyrosine kinase (BTK) inhibitor that received all four expedited programs of the FDA: Fast-Track designation, Breakthrough Therapy designation, Priority Review, and Accelerated Approval. Both approvals were based on overall response rate (ORR) and duration of response (DOR) in single-arm clinical trials in patients with prior treatment. In MCL (N = 111), the complete and partial response rates were 17.1% and 48.6%, respectively, for an ORR of 65.8% [95% confidence interval (CI), 56.2%-74.5%]. The median DOR was 17.5 months (95% CI, 15.8-not reached). In CLL (N = 48), the ORR was 58.3% (95% CI, 43.2%-72.4%), and the DOR ranged from 5.6 to 24.2 months. The most common adverse reactions ( greater than or equal to 30% in either trial) were thrombocytopenia, diarrhea, neutropenia, bruising, upper respiratory tract infection, anemia, fatigue, musculoskeletal pain, peripheral edema, and nausea. Clin Cancer Res; 21(16); 3586-90. copyright 2015 AACR. JF - Clinical Cancer Research AU - de Claro, RAngelo AU - McGinn, Karen M AU - Verdun, Nicole AU - Lee, Shwu-Luan AU - Chiu, Haw-Jyh AU - Saber, Haleh AU - Brower, Margaret E AU - Chang, CJGeorge AU - Pfuma, Elimika AU - Habtemariam, Bahru AU - Bullock, Julie AU - Wang, Yun AU - Nie, Lei AU - Chen, Xiao-Hong AU - Lu, Donghao AU - Al-Hakim, Ali AU - Kane, Robert C AU - Kaminskas, Edvardas AU - Justice, Robert AU - Farrell, Ann T AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, romeo.declaro@fda.hhs.gov Y1 - 2015/08/15/ PY - 2015 DA - 2015 Aug 15 SP - 3586 EP - 3590 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 21 IS - 16 SN - 1078-0432, 1078-0432 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Fatigue KW - Diarrhea KW - Anemia KW - Edema KW - Pain KW - Clinical trials KW - Cancer KW - Neutropenia KW - Respiratory tract diseases KW - mantle cell lymphoma KW - Thrombocytopenia KW - Nausea KW - Chronic lymphatic leukemia KW - Side effects KW - Bruton's tyrosine kinase KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808618284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=FDA+Approval%3A+Ibrutinib+for+Patients+with+Previously+Treated+Mantle+Cell+Lymphoma+and+Previously+Treated+Chronic+Lymphocytic+Leukemia&rft.au=de+Claro%2C+RAngelo%3BMcGinn%2C+Karen+M%3BVerdun%2C+Nicole%3BLee%2C+Shwu-Luan%3BChiu%2C+Haw-Jyh%3BSaber%2C+Haleh%3BBrower%2C+Margaret+E%3BChang%2C+CJGeorge%3BPfuma%2C+Elimika%3BHabtemariam%2C+Bahru%3BBullock%2C+Julie%3BWang%2C+Yun%3BNie%2C+Lei%3BChen%2C+Xiao-Hong%3BLu%2C+Donghao%3BAl-Hakim%2C+Ali%3BKane%2C+Robert+C%3BKaminskas%2C+Edvardas%3BJustice%2C+Robert%3BFarrell%2C+Ann+T%3BPazdur%2C+Richard&rft.aulast=de+Claro&rft.aufirst=RAngelo&rft.date=2015-08-15&rft.volume=21&rft.issue=16&rft.spage=3586&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-2225 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Diarrhea; Fatigue; Anemia; Edema; Pain; Clinical trials; Cancer; Respiratory tract diseases; Neutropenia; mantle cell lymphoma; Thrombocytopenia; Nausea; Chronic lymphatic leukemia; Bruton's tyrosine kinase; Side effects DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-2225 ER - TY - JOUR T1 - Thalidomide induced early gene expression perturbations indicative of human embryopathy in mouse embryonic stem cells. AN - 1693711060; 26006729 AB - Developmental toxicity testing has traditionally relied on animal models which are costly, time consuming, and require the sacrifice of large numbers of animals. In addition, there are significant disparities between human beings and animals in their responses to chemicals. Thalidomide is a species-specific developmental toxicant that causes severe limb malformations in humans but not in mice. Here, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro model based on differentiation of mouse embryonic stem cells (mESCs). C57BL/6 mESCs were allowed to differentiate spontaneously and RNA was collected at 24, 48, and 72h after exposure to 0.25mM thalidomide. Global gene expression analysis using microarrays revealed hundreds of differentially expressed genes upon thalidomide exposure that were enriched in gene ontology (GO) terms and canonical pathways associated with embryonic development and differentiation. In addition, many genes were found to be involved in small GTPases-mediated signal transduction, heart development, and inflammatory responses, which coincide with clinical evidences and may represent critical embryotoxicities of thalidomide. These results demonstrate that transcriptomics in combination with mouse embryonic stem cell differentiation is a promising alternative model for developmental toxicity assessment. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Gao, Xiugong AU - Sprando, Robert L AU - Yourick, Jeffrey J AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, United States. Electronic address: xiugong.gao@fda.hhs.gov. ; Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, United States. Y1 - 2015/08/15/ PY - 2015 DA - 2015 Aug 15 SP - 43 EP - 51 VL - 287 IS - 1 KW - Thalidomide KW - 4Z8R6ORS6L KW - Index Medicus KW - Differentiation KW - Microarray KW - Transcriptomics KW - Developmental toxicity KW - Mouse KW - Embryonic stem cell KW - Real-Time Polymerase Chain Reaction KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Gene Regulatory Networks -- drug effects KW - Humans KW - Gene Expression Profiling -- methods KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Toxicity Tests -- methods KW - Toxicogenetics -- methods KW - Species Specificity KW - Time Factors KW - Transcriptome -- drug effects KW - Pluripotent Stem Cells -- drug effects KW - Embryonic Stem Cells -- metabolism KW - Embryonic Stem Cells -- drug effects KW - Pluripotent Stem Cells -- pathology KW - Thalidomide -- toxicity KW - Embryonic Stem Cells -- pathology KW - Gene Expression Regulation, Developmental -- drug effects KW - Pluripotent Stem Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1693711060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Thalidomide+induced+early+gene+expression+perturbations+indicative+of+human+embryopathy+in+mouse+embryonic+stem+cells.&rft.au=Gao%2C+Xiugong%3BSprando%2C+Robert+L%3BYourick%2C+Jeffrey+J&rft.aulast=Gao&rft.aufirst=Xiugong&rft.date=2015-08-15&rft.volume=287&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2015.05.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-14 N1 - Date created - 2015-07-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2015.05.009 ER - TY - JOUR T1 - The time to most recent common ancestor does not (usually) approximate the date of divergence AN - 1734270907; 2015-112673 AB - With the advent of more sophisticated models and increase in computational power, an ever-growing amount of information can be extracted from DNA sequence data. In particular, recent advances have allowed researchers to estimate the date of historical events for a group of interest including time to most recent common ancestor (TMRCA), dates of specific nodes in a phylogeny, and the date of divergence or speciation date. Here I use coalescent simulations and re-analyze an empirical dataset to illustrate the importance of taxon sampling, in particular, on correctly estimating such dates. I show that TMRCA of representatives of a single taxon is often not the same as divergence date due to issues such as incomplete lineage sorting. Of critical importance is when estimating divergence or speciation dates a representative from a different taxonomic lineage must be included in the analysis. Without considering these issues, studies may incorrectly estimate the times at which historical events occurred, which has profound impacts within both research and applied (e.g., those related to public health) settings. JF - PLoS One AU - Pettengill, James B Y1 - 2015/08/14/ PY - 2015 DA - 2015 Aug 14 PB - Public Library of Science, San Francisco, CA VL - 2015 IS - e0128407 KW - methods KW - Quaternary KW - living taxa KW - phylogeny KW - biologic evolution KW - molecular clocks KW - coalescent simulations KW - upper Pleistocene KW - genetics KW - Cenozoic KW - nucleic acids KW - speciation KW - Salmonella enterica KW - bacteria KW - DNA KW - Pleistocene KW - 09:Paleobotany UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734270907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+One&rft.atitle=The+time+to+most+recent+common+ancestor+does+not+%28usually%29+approximate+the+date+of+divergence&rft.au=Pettengill%2C+James+B&rft.aulast=Pettengill&rft.aufirst=James&rft.date=2015-08-14&rft.volume=2015&rft.issue=e0128407&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+One&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0128407 L2 - http://journals.plos.org/plosone/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2015-01-01 N1 - Number of references - 14 N1 - PubXState - CA N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2016-09-16 N1 - SubjectsTermNotLitGenreText - bacteria; biologic evolution; Cenozoic; coalescent simulations; DNA; genetics; living taxa; methods; molecular clocks; nucleic acids; phylogeny; Pleistocene; Quaternary; Salmonella enterica; speciation; upper Pleistocene DO - http://dx.doi.org/10.1371/journal.pone.0128407 ER - TY - JOUR T1 - Draft Genome Sequence of Multidrug-Resistant Enterococcus faecium Clinical Isolate VRE3, with a Sequence Type 16 Pattern and Novel Structural Arrangement of Tn1546. AN - 1704354662; 26272564 AB - Multidrug-resistant Enterococcus faecium has emerged as a nosocomial pathogen that may infect the body at various sites, including the gastrointestinal tract, and has serious implications in human health and disease. Here, we present the draft genome sequence of clinical strain VRE3, which exhibited a sequence type 16 (ST16) pattern and carried truncated Tn1546, a mobile genetic element encoding a high level of vancomycin resistance. Copyright © 2015 Khan et al. JF - Genome announcements AU - Khan, Saeed AU - Sung, Kidon AU - Marasa, Bernard AU - Min, Seonggi AU - Kweon, Ohgew AU - Nawaz, Mohamed AU - Cerniglia, Carl AD - Division of Microbiology, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration, Jefferson, Arkansas, USA saeed.khan@fda.hhs.gov. ; Division of Microbiology, National Center for Toxicological Research (NCTR), U.S. Food and Drug Administration, Jefferson, Arkansas, USA. ; Division of Microbiological Assessment, Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration, Silver Spring, Maryland, USA. ; Office of Scientific Coordination, NCTR, U.S. Food and Drug Administration, Jefferson, Arkansas, USA. Y1 - 2015/08/13/ PY - 2015 DA - 2015 Aug 13 VL - 3 IS - 4 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704354662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+announcements&rft.atitle=Draft+Genome+Sequence+of+Multidrug-Resistant+Enterococcus+faecium+Clinical+Isolate+VRE3%2C+with+a+Sequence+Type+16+Pattern+and+Novel+Structural+Arrangement+of+Tn1546.&rft.au=Khan%2C+Saeed%3BSung%2C+Kidon%3BMarasa%2C+Bernard%3BMin%2C+Seonggi%3BKweon%2C+Ohgew%3BNawaz%2C+Mohamed%3BCerniglia%2C+Carl&rft.aulast=Khan&rft.aufirst=Saeed&rft.date=2015-08-13&rft.volume=3&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genome+announcements&rft.issn=&rft_id=info:doi/10.1128%2FgenomeA.00871-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-14 N1 - Date created - 2015-08-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/genomeA.00871-15 ER - TY - JOUR T1 - Composition Directed Generation of Reactive Oxygen Species in Irradiated Mixed Metal Sulfides Correlated with Their Photocatalytic Activities. AN - 1702091476; 26158231 AB - The ability of nanostructures to facilitate the generation of reactive oxygen species and charge carriers underlies many of their chemical and biological activities. Elucidating which factors are essential and how these influence the production of various active intermediates is fundamental to understanding potential applications of these nanostructures, as well as potential risks. Using electron spin resonance spectroscopy coupled with spin trapping and spin labeling techniques, we assessed 3 mixed metal sulfides of varying compositions for their abilities to generate reactive oxygen species, photogenerate electrons, and consume oxygen during photoirradiation. We found these irradiated mixed metal sulfides exhibited composition dependent generation of ROS: ZnIn2S4 can generate (•)OH, O2(-•) and (1)O2; CdIn2S4 can produce O2(-•) and (1)O2, while AgInS2 only produces O2(-•). Our characterizations of the reactivity of the photogenerated electrons and consumption of dissolved oxygen, performed using spin labeling, showed the same trend in activity: ZnIn2S4 > CdIn2S4 > AgInS2. These intrinsic abilities to generate ROS and the reactivity of charge carriers correlated closely with the photocatalytic degradation and photoassisted antibacterial activities of these nanomaterials. JF - ACS applied materials & interfaces AU - He, Weiwei AU - Jia, Huimin AU - Yang, Dongfang AU - Xiao, Pin AU - Fan, Xiaoli AU - Zheng, Zhi AU - Kim, Hyun-Kyung AU - Wamer, Wayne G AU - Yin, Jun-Jie AD - †Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, Xuchang University, Xuchang, Henan 461000, P. R. China. ; §School of Materials Science and Engineering, State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China. ; ∥Food Safety Bureau, Ministry of Food and Drug Safety, Osong Health Technology Administration Complex 363-700, Republic of Korea. ; ‡Division of Bioanalytical Chemistry and Division of Analytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland 20740, United States. Y1 - 2015/08/05/ PY - 2015 DA - 2015 Aug 05 SP - 16440 EP - 16449 VL - 7 IS - 30 KW - Reactive Oxygen Species KW - 0 KW - Sulfides KW - Index Medicus KW - photocatalytic KW - reactive oxygen species KW - ESR KW - mixed metal sulfides KW - antibacterial KW - Catalysis -- radiation effects KW - Light KW - Statistics as Topic KW - Materials Testing KW - Photochemistry -- methods KW - Reactive Oxygen Species -- chemical synthesis KW - Metal Nanoparticles -- chemistry KW - Sulfides -- chemistry KW - Sulfides -- radiation effects KW - Metal Nanoparticles -- radiation effects KW - Reactive Oxygen Species -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1702091476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+applied+materials+%26+interfaces&rft.atitle=Composition+Directed+Generation+of+Reactive+Oxygen+Species+in+Irradiated+Mixed+Metal+Sulfides+Correlated+with+Their+Photocatalytic+Activities.&rft.au=He%2C+Weiwei%3BJia%2C+Huimin%3BYang%2C+Dongfang%3BXiao%2C+Pin%3BFan%2C+Xiaoli%3BZheng%2C+Zhi%3BKim%2C+Hyun-Kyung%3BWamer%2C+Wayne+G%3BYin%2C+Jun-Jie&rft.aulast=He&rft.aufirst=Weiwei&rft.date=2015-08-05&rft.volume=7&rft.issue=30&rft.spage=16440&rft.isbn=&rft.btitle=&rft.title=ACS+applied+materials+%26+interfaces&rft.issn=1944-8252&rft_id=info:doi/10.1021%2Facsami.5b03626 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-29 N1 - Date created - 2015-08-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acsami.5b03626 ER - TY - JOUR T1 - Analysis of lasalocid residues in grease and fat using liquid chromatography-mass spectrometry AN - 1717500283; PQ0002012354 AB - A method for the determination of lasalocid, an antibiotic and coccidiostat, in grease and fat is described. The manufacture of lasalocid produces a grease-like residue as a waste byproduct. Recently this byproduct has been shown to have been illegally introduced into the animal feed chain. Therefore, a quantitative and confirmatory procedure to analyse for lasalocid in this matrix is needed. A portion of grease/oil sample was extracted into hexane-washed acetonitrile, and a portion of the extract was then applied to a carboxylic acid solid-phase extraction (SPE) column for concentration and clean-up. The SPE column was washed with additional hexane-washed acetonitrile and ethyl acetate/methanol, after which lasalocid was eluted with 10% ammoniated methanol. The eluate was evaporated to dryness, redissolved in (1:1) acetonitrile-water and filtered through a PTFE syringe filter. Confirmation and quantitation of lasalocid in the final extract employed a triple quadrupole LC-MS/MS. The method was applied to grease and oil samples containing from 0.02 to 34 000 mg kg super(-1) of lasalocid. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Clark, Susan B AU - Storey, Joseph M AU - Carr, Justin R AU - Madson, Mark AD - Denver Laboratory, US Food and Drug Administration (USFDA), Denver, CO, USA PY - 2015 SP - 1243 EP - 1248 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 8 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Risk assessment KW - Residues KW - Byproducts KW - Methanol KW - Antibiotics KW - Spectrometry KW - Oil KW - Filters KW - Food additives KW - Carboxylic acids KW - Syringes KW - Animal feeds KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717500283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Analysis+of+lasalocid+residues+in+grease+and+fat+using+liquid+chromatography-mass+spectrometry&rft.au=Clark%2C+Susan+B%3BStorey%2C+Joseph+M%3BCarr%2C+Justin+R%3BMadson%2C+Mark&rft.aulast=Clark&rft.aufirst=Susan&rft.date=2015-08-03&rft.volume=32&rft.issue=8&rft.spage=1243&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1052572 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Filters; Risk assessment; Oil; Food additives; Residues; Methanol; Byproducts; Carboxylic acids; Animal feeds; Syringes; Antibiotics; Spectrometry DO - http://dx.doi.org/10.1080/19440049.2015.1052572 ER - TY - JOUR T1 - FDA Approval Summary: Ramucirumab for Gastric Cancer AN - 1808643082; PQ0003449714 AB - The FDA approved ramucirumab (CYRAMZA; Eli Lilly and Company) for previously treated patients with advanced or metastatic gastric or gastroesophageal junction adenocarcinoma initially as monotherapy (April 21, 2014) and subsequently as combination therapy with paclitaxel (November 5, 2014). In the monotherapy trial, 355 patients in the indicated population were randomly allocated (2:1) to receive ramucirumab or placebo, 8 mg/kg intravenously every 2 weeks. In the combination trial, 665 patients were randomly allocated (1:1) to receive ramucirumab or placebo, 8 mg/kg intravenously every 2 weeks, in combination with paclitaxel, 80 mg/m2 on days 1, 8, and 15 of 28-day cycles. Overall survival (OS) was increased in patients who received ramucirumab in both the monotherapy [HR, 0.78; 95% confidence interval (CI), 0.60-0.998; log rank P = 0.047] and combination trials (HR, 0.81; 95% CI, 0.68-0.96; P = 0.017). The most common adverse reactions were hypertension and diarrhea in the monotherapy trial and fatigue, neutropenia, diarrhea, and epistaxis in the combination trial. Because of concerns about the robustness of the monotherapy trial results, FDA approved the original application after receiving the results of the combination trial confirming the OS effect. Based on exploratory exposure-response analyses, there is residual uncertainty regarding the optimal dose of ramucirumab. Clin Cancer Res; 21(15); 3372-6. copyright 2015 AACR. JF - Clinical Cancer Research AU - Casak, Sandra J AU - Fashoyin-Aje, Ibilola AU - Lemery, Steven J AU - Zhang, Lillian AU - Jin, Runyan AU - Li, Hongshan AU - Zhao, Liang AU - Zhao, Hong AU - Zhang, Hui AU - Chen, Huanyu AU - He, Kun AU - Dougherty, Michele AU - Novak, Rachel AU - Kennett, Sarah AU - Khasar, Sachia AU - Helms, Whitney AU - Keegan, Patricia AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, Maryland, Sandra.Casak@fda.hhs.gov Y1 - 2015/08/01/ PY - 2015 DA - 2015 Aug 01 SP - 3372 EP - 3376 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 21 IS - 15 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Diarrhea KW - Fatigue KW - Survival KW - Clinical trials KW - Metastases KW - Neutropenia KW - Paclitaxel KW - Dose-response effects KW - Adenocarcinoma KW - Gastric cancer KW - Side effects KW - Hypertension KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808643082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=FDA+Approval+Summary%3A+Ramucirumab+for+Gastric+Cancer&rft.au=Casak%2C+Sandra+J%3BFashoyin-Aje%2C+Ibilola%3BLemery%2C+Steven+J%3BZhang%2C+Lillian%3BJin%2C+Runyan%3BLi%2C+Hongshan%3BZhao%2C+Liang%3BZhao%2C+Hong%3BZhang%2C+Hui%3BChen%2C+Huanyu%3BHe%2C+Kun%3BDougherty%2C+Michele%3BNovak%2C+Rachel%3BKennett%2C+Sarah%3BKhasar%2C+Sachia%3BHelms%2C+Whitney%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Casak&rft.aufirst=Sandra&rft.date=2015-08-01&rft.volume=21&rft.issue=15&rft.spage=3372&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-15-0600 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Metastases; Neutropenia; Fatigue; Diarrhea; Paclitaxel; Dose-response effects; Survival; Gastric cancer; Adenocarcinoma; Clinical trials; Side effects; Hypertension DO - http://dx.doi.org/10.1158/1078-0432.CCR-15-0600 ER - TY - JOUR T1 - Services for children with autism spectrum disorder in three, large urban school districts: Perspectives of parents and educators AN - 1790893360 AB - This study used qualitative methods to evaluate the perceptions of parents, educators, and school administrators in three large, urban school districts (Los Angeles, Philadelphia, and Rochester) regarding services for children with autism spectrum disorder within the context of limited district resources. Facilitators followed a standard discussion guide that contained open-ended questions regarding participants' views on strengths and limitations of existing services and contextual factors that would facilitate or inhibit the process of introducing new interventions. Three primary themes were identified: (1) tension between participant groups (teachers and paraprofessionals, staff and administration, teachers and parents, special education and general education teachers), (2) necessity of autism spectrum disorder-specific and behavioral training for school personnel, and (3) desire for a school culture of accepting difference. These themes highlight the importance of developing trainings that are feasible to deliver on a large scale, that focus on practical interventions, and that enhance communication and relationships of school personnel with one another and with families. JF - Autism AU - Iadarola, Suzannah AU - Hetherington, Susan AU - Clinton, Christopher AU - Dean, Michelle AU - Reisinger, Erica AU - Huynh, Linh AU - Locke, Jill AU - Conn, Kelly AU - Heinert, Sara AU - Kataoka, Sheryl AU - Harwood, Robin AU - Smith, Tristram AU - Mandell, David S AU - Kasari, Connie AD - University of Rochester Medical Center, New York, USA ; University of California, Los Angeles, USA ; University of Pennsylvania, Pennsylvania, USA ; Health Resources & Services Administration, Maternal and Child Health Bureau, Maryland, USA Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 694 EP - 703 CY - London PB - SAGE PUBLICATIONS, INC. VL - 19 IS - 6 SN - 1362-3613 KW - Psychology KW - autism KW - community-based participatory research KW - qualitative research KW - school-based intervention KW - urban environments KW - Attitudes KW - Autistic children KW - Autistic spectrum disorders KW - Behavioural training KW - Contextual factors KW - Desire KW - Facilitators KW - General education KW - Interventions KW - Necessity KW - Paraprofessionals KW - Parenthood education KW - Parents KW - Personnel KW - Qualitative methods KW - Special education KW - Teachers KW - Los Angeles California UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1790893360?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Autism&rft.atitle=Services+for+children+with+autism+spectrum+disorder+in+three%2C+large+urban+school+districts%3A+Perspectives+of+parents+and+educators&rft.au=Iadarola%2C+Suzannah%3BHetherington%2C+Susan%3BClinton%2C+Christopher%3BDean%2C+Michelle%3BReisinger%2C+Erica%3BHuynh%2C+Linh%3BLocke%2C+Jill%3BConn%2C+Kelly%3BHeinert%2C+Sara%3BKataoka%2C+Sheryl%3BHarwood%2C+Robin%3BSmith%2C+Tristram%3BMandell%2C+David+S%3BKasari%2C+Connie&rft.aulast=Iadarola&rft.aufirst=Suzannah&rft.date=2015-08-01&rft.volume=19&rft.issue=6&rft.spage=694&rft.isbn=&rft.btitle=&rft.title=Autism&rft.issn=13623613&rft_id=info:doi/10.1177%2F1362361314548078 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - © The Author(s) 2014 N1 - Last updated - 2017-02-08 N1 - SubjectsTermNotLitGenreText - Los Angeles California DO - http://dx.doi.org/10.1177/1362361314548078 ER - TY - JOUR T1 - Further Trends in Work-Related Musculoskeletal Disorders: A Comparison of Risk Factors for Symptoms Using Quality of Work Life Data From the 2002, 2006, and 2010 General Social Survey AN - 1722164459; PQ0002041235 AB - Objective: To report trends for the risk of musculoskeletal disorders. Methods: Three Quality of Work Life surveys examine the risk factors for musculoskeletal disorders. Results: Findings similar for several risk factors, but differences across the reporting years may reflect economic conditions. Respondent numbers in 2010 were reduced, some risk factors had pattern changes, and there were sex and age differences. Trend analysis showed most significant changes were for the "work fast" risk factor. New 2010 "physical effort" item showed sex differences, and items reflective of total worker health showed strong associations with "back pain" and "pain in arms." Conclusions: Intervention strategies should focus on physical exposures and psychosocial risk factors (work stress, safety climate, job satisfaction, supervisor support, work fast, work freedom, work time) that have been consistently related to reports of musculoskeletal disorders. Economic conditions will influence some psychosocial risk factors. JF - Journal of Occupational and Environmental Medicine AU - Dick, Robert B AU - Lowe, Brian D AU - Lu, Ming-Lun AU - Krieg, Edward F AD - US Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Safety and Occupational Health, Division of Applied Research and Technology, Organizational Science and Human Factors Branch, Cincinnati, Ohio, RBD1@cdc.gov PY - 2015 SP - 910 EP - 928 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 8 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Climate KW - Safety KW - Intervention KW - Stress KW - Pain KW - Back pain KW - Health risks KW - Musculoskeletal system KW - Risk factors KW - Economic conditions KW - Occupational health KW - H 1000:Occupational Safety and Health KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722164459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Further+Trends+in+Work-Related+Musculoskeletal+Disorders%3A+A+Comparison+of+Risk+Factors+for+Symptoms+Using+Quality+of+Work+Life+Data+From+the+2002%2C+2006%2C+and+2010+General+Social+Survey&rft.au=Dick%2C+Robert+B%3BLowe%2C+Brian+D%3BLu%2C+Ming-Lun%3BKrieg%2C+Edward+F&rft.aulast=Dick&rft.aufirst=Robert&rft.date=2015-08-01&rft.volume=57&rft.issue=8&rft.spage=910&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000501 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Health risks; Age; Musculoskeletal system; Risk factors; Safety; Climate; Stress; Intervention; Pain; Economic conditions; Back pain; Occupational health DO - http://dx.doi.org/10.1097/JOM.0000000000000501 ER - TY - JOUR T1 - Developing Surveillance Methodology for Agricultural and Logging Injury in New Hampshire Using Electronic Administrative Data Sets AN - 1722164426; PQ0002041229 AB - Objective: Agriculture and logging rank among industries with the highest rates of occupational fatality and injury. Establishing a nonfatal injury surveillance system is a top priority in the National Occupational Research Agenda. Sources of data such as patient care reports (PCRs) and hospitalization data have recently transitioned to electronic databases. Methods: Using narrative and location codes from PCRs, along with International Classification of Diseases, 9th Revision, external cause of injury codes (E-codes) in hospital data, researchers are designing a surveillance system to track farm and logging injury. Results: A total of 357 true agricultural or logging cases were identified. Conclusions: These data indicate that it is possible to identify agricultural and logging injury events in PCR and hospital data. Multiple data sources increase catchment; nevertheless, limitations in methods of identification of agricultural and logging injury contribute to the likely undercount of injury events. JF - Journal of Occupational and Environmental Medicine AU - Scott, Erika E AU - Hirabayashi, Liane AU - Krupa, Nicole L AU - Sorensen, Julie A AU - Jenkins, Paul L AD - Northeast Center for Occupational Health in Agriculture, Forestry and Fishing, NIOSH AgFF Center, Cooperstown, NY, erika.scott@bassett.org Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 866 EP - 872 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 8 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722164426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Developing+Surveillance+Methodology+for+Agricultural+and+Logging+Injury+in+New+Hampshire+Using+Electronic+Administrative+Data+Sets&rft.au=Scott%2C+Erika+E%3BHirabayashi%2C+Liane%3BKrupa%2C+Nicole+L%3BSorensen%2C+Julie+A%3BJenkins%2C+Paul+L&rft.aulast=Scott&rft.aufirst=Erika&rft.date=2015-08-01&rft.volume=57&rft.issue=8&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000482 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-10-15 DO - http://dx.doi.org/10.1097/JOM.0000000000000482 ER - TY - RPRT T1 - Table of contents AN - 1719234706 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1719234706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-08-01&rft.volume=&rft.issue=582&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2015 N1 - Last updated - 2015-10-06 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF VINYLIDENE CHLORIDE (CAS NO. 75-35-4) IN F344/N RATS AND B6C3F1/N MICE (INHALATION STUDIES) AN - 1719234607 AB - Vinylidene chloride is used to produce a variety of polymers, including fdms for food containers and coatings for products ranging from carpets and tapes to railroad containers. We exposed groups of 50 male and 50 female rats to atmospheres containing vapors of vinylidene chloride at concentrations of 25, 50, or 100 parts per million (ppm) for six hours per day, five days per week for two years; groups of mice were similarly exposed to atmospheres containing 6.25, 12.5, or 25 ppm of vinylidene chloride. Groups of 50 male and 50 female rats and mice exposed to clean air in the same type of inhalation chambers served as the control groups. Tissues from more than 40 sites were examined for every animal. All groups of male and female rats and mice exposed to vinylidene chloride had extensive non-cancerous lesions of the epithelium of the nose, including inflammation, metaplasia, hyperplasia, and atrophy. Male rats had markedly increased incidences of malignant mesotheliomas and some rare adenomas of the respiratory epithelium of the nose. Female rats had increased incidences of thyroid gland cancers and mononuclear cell leukemia. Male mice had marked increases of uncommon benign and malignant tumors of the kidney and female mice had increased incidences of hemangioma or hemangiosarcoma in all organs and a variety of liver tumors. We conclude that exposure to vinylidene chloride by inhalation caused malignant mesothelioma and cancers in the nose in male rats, thyroid gland cancers and mononuclear cell leukemia in female rats, kidney cancers in male mice, and hemangioma or hemangiosarcoma in all organs and liver tumors in female mice. A spectrum of nonneoplastic lesions in the nose of male and female rats and mice were caused by vinylidene chloride exposure. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 0_1,0_2,6 EP - 37,39-83C,85-91,93-115,117-163,165-175,177-189,191-193,195-229 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Toxicology KW - Rodents KW - Polymers KW - Cancer KW - Human exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1719234607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+VINYLIDENE+CHLORIDE+%28CAS+NO.+75-35-4%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2015-08-01&rft.volume=&rft.issue=582&rft.spage=0_1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2015 N1 - Document feature - Tables; Diagrams; Graphs; References N1 - Last updated - 2015-10-06 ER - TY - JOUR T1 - Retention of virulence following adaptation to colistin in Acinetobacter baumannii reflects the mechanism of resistance AN - 1712562905; PQ0001944553 AB - Objectives Colistin resistance in Acinetobacter baumannii has been associated with loss of virulence and a negative impact on isolate selection. In this study, exposure of clinical isolates to suboptimal concentrations of colistin was used to explore the capacity to develop resistance by diverse mechanisms, and whether acquired resistance always reduces fitness and virulence. Methods Twelve colistin-susceptible clinical A. baumannii isolates were exposed to a sub-MIC concentration of colistin over 6 weeks with weekly increases in concentration. Stable resistance was then phenotypically investigated with respect to antibiotic/biocide resistance, virulence in Galleria mellonella and growth rate. Putative mechanisms of resistance were identified by targeted sequencing of known resistance loci. Results Eight A. baumannii isolates acquired resistance to colistin within 1 week with MICs ranging from 2 to >512 mg/L. By 6 weeks 11 isolates were resistant to colistin; this was linked to the development of mutations in pmr or lpx genes. Strains that developed mutations in lpxACD showed a loss of virulence and increased susceptibility to several antibiotics/disinfectants tested. Two of the colistin-resistant strains with mutations in pmrB retained similar virulence levels to their respective parental strains in G. mellonella. Conclusions Acquisition of colistin resistance does not always lead to a loss of virulence, especially when this is linked to mutations in pmrB. This underlines the importance of understanding the mechanism of colistin resistance as well as the phenotype. JF - Journal of Antimicrobial Chemotherapy AU - Wand, Matthew E AU - Bock, Lucy J AU - Bonney, Laura C AU - Sutton, J Mark AD - Corresponding author. Tel: +44-(0)1980-612316; Fax: +44-(0)1980-612622; , matthew.wand@phe.gov.uk Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2209 EP - 2216 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 70 IS - 8 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Acinetobacter baumannii KW - colistin adaptation KW - Galleria mellonella KW - antibiotic resistance KW - Clinical isolates KW - Fitness KW - Growth rate KW - Adaptations KW - Antibiotics KW - Minimum inhibitory concentration KW - Colistin KW - Virulence KW - Disinfectants KW - Biocides KW - Mutation KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712562905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Retention+of+virulence+following+adaptation+to+colistin+in+Acinetobacter+baumannii+reflects+the+mechanism+of+resistance&rft.au=Wand%2C+Matthew+E%3BBock%2C+Lucy+J%3BBonney%2C+Laura+C%3BSutton%2C+J+Mark&rft.aulast=Wand&rft.aufirst=Matthew&rft.date=2015-08-01&rft.volume=70&rft.issue=8&rft.spage=2209&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkv097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Growth rate; Fitness; Clinical isolates; Virulence; Colistin; Disinfectants; Adaptations; Antibiotics; Biocides; Minimum inhibitory concentration; Mutation; Acinetobacter baumannii; Galleria mellonella DO - http://dx.doi.org/10.1093/jac/dkv097 ER - TY - JOUR T1 - Correction of overstatement and omission in direct-to-consumer prescription drug advertising AN - 1710254655; 4699741 AB - Little experimental evidence exists regarding corrective television advertising as a remedy for misleading direct-to‐ ;consumer prescription drug ads. We examined how exposure to an ad for a fictitious prescription drug that appeared to offer benefits and risks superior to normative standards for asthma medication (i.e., a simulated violative ad) and a corresponding corrective ad shaped viewer perceptions, understanding, and intended behavior. Through an experiment with 1,057 participants, we found that a corrective ad counteracted viewer belief of an overstatement of efficacy claim, but was less successful in counteracting omission of risk. Corrective ad exposure also affected general viewer perceptions of, and intended behaviors toward, the drug. Reprinted by permission of Blackwell Publishers JF - Journal of communication AU - O' Donoghue, Amie C AU - Rupert, Douglas J AU - Lee, Philip K AU - Amoozegar, Jacqueline B AU - Southwell, Brian G AU - Aikin, Kathryn J AU - Betts, Kevin R AD - US Food and Drug Administration ; RTI International Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 596 EP - 618 VL - 65 IS - 4 SN - 0021-9916, 0021-9916 KW - Sociology KW - Perception KW - Television KW - Consumers KW - Correlation KW - Advertising KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1710254655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+communication&rft.atitle=Correction+of+overstatement+and+omission+in+direct-to-consumer+prescription+drug+advertising&rft.au=O%27+Donoghue%2C+Amie+C%3BRupert%2C+Douglas+J%3BLee%2C+Philip+K%3BAmoozegar%2C+Jacqueline+B%3BSouthwell%2C+Brian+G%3BAikin%2C+Kathryn+J%3BBetts%2C+Kevin+R&rft.aulast=O%27+Donoghue&rft.aufirst=Amie&rft.date=2015-08-01&rft.volume=65&rft.issue=4&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Journal+of+communication&rft.issn=00219916&rft_id=info:doi/10.1111%2Fjcom.12167 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-09-09 N1 - Last updated - 2015-09-09 N1 - SubjectsTermNotLitGenreText - 12648 7862 2572; 608 7738 11245 11239; 3755; 2803 3874 556; 9382; 2904 12224 971 DO - http://dx.doi.org/10.1111/jcom.12167 ER - TY - JOUR T1 - Quantile benchmark dose estimation for continuous endpoints AN - 1709765532; PQ0001722505 AB - Quantitative risk assessment (QRA) characterizes the risk of an adverse health outcome for an organism exposed to a chemical, environmental, physical, or other hazard. Historically, QRAs define risk based upon the increased probability of adverse response because of exposure when compared with the background probability of response in unexposed individuals. For a specified risk level, the exposure-response relationship is inverted to find an exposure (or dose) for minimizing risk; these exposures are often called the benchmark dose (BMD). For continuous endpoints, BMD analyses have employed strong assumptions on the form of the response distribution which may not be met for most toxicology data sets. We propose a reformulation of the BMD for use in QRA for continuous response that is based upon milder assumptions using quantile regression and monotone smoothing splines. This method takes into account the uncertainty in the response distribution as well as uncertainty in the exposure-response relationship. We apply this method to a data example and show through a simulation study that the approach is often superior to current practice. JF - Environmetrics AU - Wheeler, Matthew W AU - Shao, Kan AU - Bailer, AJohn AD - National Institute for Occupational Safety and Health, Cincinnati, OH 45226, U.S.A. Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 363 EP - 372 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 26 IS - 5 SN - 1180-4009, 1180-4009 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Uncertainty KW - Risk KW - Data sets KW - Quantiles KW - Exposure KW - Regression analysis KW - Regression KW - Benchmarking UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709765532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmetrics&rft.atitle=Quantile+benchmark+dose+estimation+for+continuous+endpoints&rft.au=Wheeler%2C+Matthew+W%3BShao%2C+Kan%3BBailer%2C+AJohn&rft.aulast=Wheeler&rft.aufirst=Matthew&rft.date=2015-08-01&rft.volume=26&rft.issue=5&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Environmetrics&rft.issn=11804009&rft_id=info:doi/10.1002%2Fenv.2342 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-12-07 DO - http://dx.doi.org/10.1002/env.2342 ER - TY - JOUR T1 - A high-resolution computational model of the deforming human heart AN - 1709190514; PQ0001897716 AB - Modeling of the heart ventricles is one of the most challenging tasks in soft tissue mechanics because cardiac tissue is a strongly anisotropic incompressible material with an active component of stress. In most current approaches with active force, the number of degrees of freedom (DOF) is limited by the direct method of solution of linear systems of equations. We develop a new approach for high-resolution heart models with large numbers of DOF by: (1) developing a hex-dominant finite element mixed formulation and (2) developing a Krylov subspace iterative method that is able to solve the system of linearized equations for saddle-point problems with active stress. In our approach, passive cardiac tissue is modeled as a hyperelastic, incompressible material with orthotropic properties, and mixed pressure-displacement finite elements are used to enforce incompressibility. Active stress is generated by a model with force dependence on length and velocity of muscle shortening. The ventricles are coupled to a lumped circulatory model. For efficient solution of linear systems, we use Flexible GMRES with a nonlinear preconditioner based on block matrix decomposition involving the Schur complement. Three methods for approximating the inverse of the Schur complement are evaluated: inverse of the pressure mass matrix; least squares commutators; and sparse approximate inverse. The sub-matrix corresponding to the displacement variables is preconditioned by a V-cycle of hybrid geometric-algebraic multigrid followed by correction with several iterations of GMRES preconditioned by sparse approximate inverse. The overall solver is demonstrated on a high-resolution two ventricle mesh based on a human anatomy with roughly 130 K elements and 1.7 M displacement DOF. Effectiveness of the numerical method for active contraction is shown. To the best of our knowledge, this solver is the first to efficiently model ventricular contraction using an iterative linear solver for the mesh size demonstrated and therefore opens the possibility for future very high-resolution models. In addition, several relatively simple benchmark problems are designed for a verification exercise to show that the solver is functioning properly and correctly solves the underlying mathematical model. Here, the output of the newly designed solver is compared to that of the mechanics component of Chaste ('Cancer, Heart and Soft Tissue Environment'). These benchmark tests may be used by other researchers to verify their newly developed methods and codes. JF - Biomechanics and Modeling in Mechanobiology AU - Gurev, Viatcheslav AU - Pathmanathan, Pras AU - Fattebert, Jean-Luc AU - Wen, Hui-Fang AU - Magerlein, John AU - Gray, Richard A AU - Richards, David F AU - Rice, JJeremy AD - Thomas J. Watson Research Center, IBM Research, 1101 Kitchawan Rd, Yorktown Heights, NY, 10598, USA, pras.pathmanathan@fda.hhs.gov Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 829 EP - 849 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 14 IS - 4 SN - 1617-7959, 1617-7959 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Calcium & Calcified Tissue Abstracts KW - Heart KW - Muscle contraction KW - Mathematical models KW - Anisotropy KW - Stress KW - Cancer KW - Physical training KW - Ventricle KW - Hybrids KW - Pressure KW - Soft tissues KW - Mechanical properties KW - N3 11002:Computational & theoretical neuroscience KW - T 2010:Muscle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709190514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomechanics+and+Modeling+in+Mechanobiology&rft.atitle=A+high-resolution+computational+model+of+the+deforming+human+heart&rft.au=Gurev%2C+Viatcheslav%3BPathmanathan%2C+Pras%3BFattebert%2C+Jean-Luc%3BWen%2C+Hui-Fang%3BMagerlein%2C+John%3BGray%2C+Richard+A%3BRichards%2C+David+F%3BRice%2C+JJeremy&rft.aulast=Gurev&rft.aufirst=Viatcheslav&rft.date=2015-08-01&rft.volume=14&rft.issue=4&rft.spage=829&rft.isbn=&rft.btitle=&rft.title=Biomechanics+and+Modeling+in+Mechanobiology&rft.issn=16177959&rft_id=info:doi/10.1007%2Fs10237-014-0639-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 60 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Heart; Muscle contraction; Ventricle; Anisotropy; Mathematical models; Hybrids; Stress; Pressure; Soft tissues; Cancer; Physical training; Mechanical properties DO - http://dx.doi.org/10.1007/s10237-014-0639-8 ER - TY - JOUR T1 - Reaerosolization of Spores from Flooring Surfaces To Assess the Risk of Dissemination and Transmission of Infections AN - 1709186555; PQ0001900749 AB - The aim of this study was to quantify reaerosolization of microorganisms caused by walking on contaminated flooring to assess the risk to individuals accessing areas contaminated with pathogenic organisms, for example, spores of Bacillus anthracis. Industrial carpet and polyvinyl chloride (PVC) floor coverings were contaminated with aerosolized spores of Bacillus atrophaeus by using an artist airbrush to produce deposition of similar to 103 to 104 CFU . cm-2. Microbiological air samplers were used to quantify the particle size distribution of the aerosol generated when a person walked over the floorings in an environmental chamber. Results were expressed as reaerosolization factors (percent per square centimeter per liter), to represent the ratio of air concentration to surface concentration generated. Walking on carpet generated a statistically significantly higher reaerosolization factor value than did walking on PVC (t = 20.42; P < 0.001). Heavier walking produced a statistically significantly higher reaerosolization factor value than did lighter walking (t = 12.421; P < 0.001). Height also had a statistically significant effect on the reaerosolization factor, with higher rates of recovery of B. atrophaeus at lower levels, demonstrating a height-dependent gradient of particle reaerosolization. Particles in the respirable size range were recovered in all sampling scenarios (mass mean diameters ranged from 2.6 to 4.1 mu m). The results of this study can be used to produce a risk assessment of the potential aerosol exposure of a person accessing areas with contaminated flooring in order to inform the choice of appropriate respiratory protective equipment and may aid in the selection of the most suitable flooring types for use in health care environments, to reduce aerosol transmission in the event of contamination. JF - Applied and Environmental Microbiology AU - Paton, Susan AU - Thompson, Katy-Anne AU - Parks, Simon R AU - Bennett, Allan M PY - 2015 SP - 4914 EP - 4919 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 15 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Particle size KW - Risk assessment KW - Aerosols KW - Contamination KW - Statistical analysis KW - polyvinyl chloride KW - Walking KW - Bacillus anthracis KW - Infection KW - Samplers KW - Disease transmission KW - Carpets KW - Colony-forming cells KW - Microorganisms KW - Sampling KW - Spores KW - Environmental chambers KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709186555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Reaerosolization+of+Spores+from+Flooring+Surfaces+To+Assess+the+Risk+of+Dissemination+and+Transmission+of+Infections&rft.au=Paton%2C+Susan%3BThompson%2C+Katy-Anne%3BParks%2C+Simon+R%3BBennett%2C+Allan+M&rft.aulast=Paton&rft.aufirst=Susan&rft.date=2015-08-01&rft.volume=81&rft.issue=15&rft.spage=4914&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00412-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 20 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Risk assessment; Particle size; Aerosols; Contamination; polyvinyl chloride; Statistical analysis; Walking; Infection; Samplers; Disease transmission; Carpets; Colony-forming cells; Microorganisms; Sampling; Spores; Environmental chambers; Bacillus anthracis DO - http://dx.doi.org/10.1128/AEM.00412-15 ER - TY - JOUR T1 - High-Resolution Analysis by Whole-Genome Sequencing of an International Lineage (Sequence Type 111) of Pseudomonas aeruginosa Associated with Metallo-Carbapenemases in the United Kingdom AN - 1709184232; PQ0001900900 AB - Whole-genome sequencing (WGS) was carried out on 87 isolates of sequence type 111 (ST-111) of Pseudomonas aeruginosa collected between 2005 and 2014 from 65 patients and 12 environmental isolates from 24 hospital laboratories across the United Kingdom on an Illumina HiSeq instrument. Most isolates (73) carried VIM-2, but others carried IMP-1 or IMP-13 (5) or NDM-1 (1); one isolate had VIM-2 and IMP-18, and 7 carried no metallo-beta-lactamase (MBL) gene. Single nucleotide polymorphism analysis divided the isolates into distinct clusters; the NDM-1 isolate was an outlier, and the IMP isolates and 6/7 MBL-negative isolates clustered separately from the main set of 73 VIM-2 isolates. Within the VIM-2 set, there were at least 3 distinct clusters, including a tightly clustered set of isolates from 3 hospital laboratories consistent with an outbreak from a single introduction that was quickly brought under control and a much broader set dominated by isolates from a long-running outbreak in a London hospital likely seeded from an environmental source, requiring different control measures; isolates from 7 other hospital laboratories in London and southeast England were also included. Bayesian evolutionary analysis indicated that all the isolates shared a common ancestor dating back similar to 50 years (1960s), with the main VIM-2 set separating approximately 20 to 30 years ago. Accessory gene profiling revealed blocks of genes associated with particular clusters, with some having high similarity ( greater than or equal to 95%) to bacteriophage genes. WGS of widely found international lineages such as ST-111 provides the necessary resolution to inform epidemiological investigations and intervention policies. JF - Journal of Clinical Microbiology AU - Turton, Jane F AU - Wright, Laura AU - Underwood, Anthony AU - Witney, Adam A AU - Chan, Yuen-Ting AU - Al-Shahib, Ali AU - Arnold, Catherine AU - Doumith, Michel AU - Patel, Bharat AU - Planche, Timothy D AD - Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health England, Colindale, London, United Kingdom, jane.turton@phe.gov.uk. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 2622 EP - 2631 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 8 SN - 0095-1137, 0095-1137 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Phages KW - Inosine monophosphate KW - Mbl protein KW - Single-nucleotide polymorphism KW - Bayesian analysis KW - Dating KW - Pseudomonas aeruginosa KW - Evolution KW - Hospitals KW - N 14845:Miscellaneous KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709184232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=High-Resolution+Analysis+by+Whole-Genome+Sequencing+of+an+International+Lineage+%28Sequence+Type+111%29+of+Pseudomonas+aeruginosa+Associated+with+Metallo-Carbapenemases+in+the+United+Kingdom&rft.au=Turton%2C+Jane+F%3BWright%2C+Laura%3BUnderwood%2C+Anthony%3BWitney%2C+Adam+A%3BChan%2C+Yuen-Ting%3BAl-Shahib%2C+Ali%3BArnold%2C+Catherine%3BDoumith%2C+Michel%3BPatel%2C+Bharat%3BPlanche%2C+Timothy+D&rft.aulast=Turton&rft.aufirst=Jane&rft.date=2015-08-01&rft.volume=53&rft.issue=8&rft.spage=2622&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00505-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 48 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Phages; Mbl protein; Inosine monophosphate; Bayesian analysis; Single-nucleotide polymorphism; Dating; Evolution; Hospitals; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1128/JCM.00505-15 ER - TY - JOUR T1 - Whole-Genome Sequencing Data for Serotyping Escherichia coli-It's Time for a Change! AN - 1709165054; PQ0001900954 AB - The accessibility of whole-genome sequencing (WGS) presents the opportunity for national reference laboratories to provide a state-of-the-art public health surveillance service. The replacement of traditional serology-based typing of Escherichia coli by WGS is supported by user-friendly, freely available data analysis Web tools. An article in this issue of the Journal of Clinical Microbiology (K. G. Joensen, A. M. M. Tetzschner, A. Iguchi, F. M. Aarestrup, and F. Scheutz, J Clin Microbiol, 53:2410-2426, 2015, http://dx.doi.org/10.1128/JCM.00008-15) describes SerotypeFinder, an essential guide to serotyping E. coli in the 21st century. JF - Journal of Clinical Microbiology AU - Jenkins, Claire Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 2402 EP - 2403 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 8 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Data processing KW - Typing KW - Escherichia coli KW - Serotyping KW - Public health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709165054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Whole-Genome+Sequencing+Data+for+Serotyping+Escherichia+coli-It%27s+Time+for+a+Change%21&rft.au=Jenkins%2C+Claire&rft.aulast=Jenkins&rft.aufirst=Claire&rft.date=2015-08-01&rft.volume=53&rft.issue=8&rft.spage=2402&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01448-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 11 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Typing; Data processing; Serotyping; Public health; Escherichia coli DO - http://dx.doi.org/10.1128/JCM.01448-15 ER - TY - JOUR T1 - Communication in a Human biomonitoring study: Focus group work, public engagement and lessons learnt in 17 European countries. AN - 1706208191; 25499539 AB - A communication strategy was developed by The Consortium to Perform Human Biomonitoring on a European Scale (COPHES), as part of its objectives to develop a framework and protocols to enable the collection of comparable human biomonitoring data throughout Europe. The framework and protocols were tested in the pilot study DEMOCOPHES (Demonstration of a study to Coordinate and Perform Human biomonitoring on a European Scale). The aims of the communication strategy were to raise awareness of human biomonitoring, encourage participation in the study and to communicate the study results and their public health significance. It identified the audiences and key messages, documented the procedure for dissemination of results and was updated as the project progressed. A communication plan listed the tools and materials such as press releases, flyers, recruitment letters and information leaflets required for each audience with a time frame for releasing them. Public insight research was used to evaluate the recruitment material, and the feedback was used to improve the documents. Dissemination of results was coordinated in a step by step approach by the participating countries within DEMOCOPHES, taking into account specific national messages according to the needs of each country. Participants received individual results, unless they refused to be informed, along with guidance on what the results meant. The aggregate results and policy recommendations were then communicated to the general public and stakeholders, followed by dissemination at European level. Several lessons were learnt that may assist other future human biomonitoring studies. Recruitment took longer than anticipated and so social scientists, to help with community engagement, should be part of the research team from the start. As a European study, involving multiple countries, additional considerations were needed for the numerous organisations, different languages, cultures, policies and priorities. Therefore, communication documents should be seen as templates with essential information clearly indicated and the option for each country to tailor the material to reflect these differences. Future studies should consider setting up multidisciplinary networks of medical professionals and communication experts, and holding training workshops to discuss the interpretation of results and risk communication. Publicity and wide dissemination of the results helped to raise awareness of human biomonitoring to the general public, policy makers and other key stakeholders. Effective and timely communication, at all stages of a study, is essential if the potential of human biomonitoring research to improve public health is to be realised. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved. JF - Environmental research AU - Exley, Karen AU - Cano, Noemi AU - Aerts, Dominique AU - Biot, Pierre AU - Casteleyn, Ludwine AU - Kolossa-Gehring, Marike AU - Schwedler, Gerda AU - Castaño, Argelia AU - Angerer, Jürgen AU - Koch, Holger M AU - Esteban, Marta AU - Schoeters, Greet AU - Den Hond, Elly AU - Horvat, Milena AU - Bloemen, Louis AU - Knudsen, Lisbeth E AU - Joas, Reinhard AU - Joas, Anke AU - Dewolf, Marie-Christine AU - Van de Mieroop, Els AU - Katsonouri, Andromachi AU - Hadjipanayis, Adamos AU - Cerna, Milena AU - Krskova, Andrea AU - Becker, Kerstin AU - Fiddicke, Ulrike AU - Seiwert, Margarete AU - Mørck, Thit A AU - Rudnai, Peter AU - Kozepesy, Szilvia AU - Cullen, Elizabeth AU - Kellegher, Anne AU - Gutleb, Arno C AU - Fischer, Marc E AU - Ligocka, Danuta AU - Kamińska, Joanna AU - Namorado, Sónia AU - Reis, M Fátima AU - Lupsa, Ioana-Rodica AU - Gurzau, Anca E AU - Halzlova, Katarina AU - Jajcaj, Michal AU - Mazej, Darja AU - Tratnik, Janja Snoj AU - Huetos, Olga AU - López, Ana AU - Berglund, Marika AU - Larsson, Kristin AU - Sepai, Ovnair AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, South Oxfordshire OX10 8BW, United Kingdom. Electronic address: karen.exley@phe.gov.uk. ; Independent TV Director and Communications Consultant, Barcelona, Spain. ; Federal Public Service Health, Food Chain Safety and Environment, Brussels, Belgium. ; University of Leuven, Leuven, Belgium. ; Federal Environment Agency (UBA), Berlin, Germany. ; Environmental Toxicology, Centro Nacional de Sanidad Ambiental, Instituto de Salud Carlos III (ISCIII), Majadahonda, Madrid, Spain. ; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance-Institute of the Ruhr-Universitat Bochum (IPA), Bochum, Germany. ; Flemish Institute for Technological Research (VITO), Environmental Risk and Health Unit, Belgium; University of Antwerp, Belgium. ; Flemish Institute for Technological Research (VITO), Environmental Risk and Health Unit, Belgium. ; Jožef Stefan Institute, Ljubljana, Slovenia. ; Environmental Health Science International, Hulst, The Netherlands. ; University of Copenhagen, Copenhagen, Denmark. ; BiPRO GmbH, Munich, Germany. ; Hainaut Vigilance Sanitaire and Hygiene Publique in Hainaut, Mons, Belgium. ; Provincial Institute for Hygiene, Kronenburgstraat 45, 2000 Antwerp, Belgium. ; State General Laboratory (SGL), Ministry of Health, Republic of Cyprus. ; Larnaca General Hospital, Ministry of Health, Republic of Cyprus. ; National Institute of Public Health, Prague, Czech Republic. ; National Institute of Environmental Health, Budapest, Hungary. ; Health Service Executive, Dublin, Ireland. ; Centre de Recherche Public Gabriel Lippmann, Belvaux, Luxembourg. ; Laboratoire National de Santé, Dudelange, Luxembourg. ; Nofer Institute of Occupational Medicine, Łódź, Poland. ; Institute of Preventive Medicine, Lisbon Faculty of Medicine, Portugal. ; Environmental Health Center, Cluj, Romania. ; Public Health Authority of the Slovak Republic, Bratislava, Slovakia. ; Karolinska Institute, Stockholm, Sweden. ; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, South Oxfordshire OX10 8BW, United Kingdom. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 31 EP - 41 VL - 141 KW - Index Medicus KW - Biomonitoring KW - Communication KW - Participatory research KW - Public insight KW - Humans KW - Information Dissemination KW - Sampling Studies KW - Europe KW - Public Policy KW - Health Policy KW - Research Design KW - Focus Groups KW - International Cooperation KW - Program Development KW - Community Participation KW - Environmental Monitoring -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1706208191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Communication+in+a+Human+biomonitoring+study%3A+Focus+group+work%2C+public+engagement+and+lessons+learnt+in+17+European+countries.&rft.au=Exley%2C+Karen%3BCano%2C+Noemi%3BAerts%2C+Dominique%3BBiot%2C+Pierre%3BCasteleyn%2C+Ludwine%3BKolossa-Gehring%2C+Marike%3BSchwedler%2C+Gerda%3BCasta%C3%B1o%2C+Argelia%3BAngerer%2C+J%C3%BCrgen%3BKoch%2C+Holger+M%3BEsteban%2C+Marta%3BSchoeters%2C+Greet%3BDen+Hond%2C+Elly%3BHorvat%2C+Milena%3BBloemen%2C+Louis%3BKnudsen%2C+Lisbeth+E%3BJoas%2C+Reinhard%3BJoas%2C+Anke%3BDewolf%2C+Marie-Christine%3BVan+de+Mieroop%2C+Els%3BKatsonouri%2C+Andromachi%3BHadjipanayis%2C+Adamos%3BCerna%2C+Milena%3BKrskova%2C+Andrea%3BBecker%2C+Kerstin%3BFiddicke%2C+Ulrike%3BSeiwert%2C+Margarete%3BM%C3%B8rck%2C+Thit+A%3BRudnai%2C+Peter%3BKozepesy%2C+Szilvia%3BCullen%2C+Elizabeth%3BKellegher%2C+Anne%3BGutleb%2C+Arno+C%3BFischer%2C+Marc+E%3BLigocka%2C+Danuta%3BKami%C5%84ska%2C+Joanna%3BNamorado%2C+S%C3%B3nia%3BReis%2C+M+F%C3%A1tima%3BLupsa%2C+Ioana-Rodica%3BGurzau%2C+Anca+E%3BHalzlova%2C+Katarina%3BJajcaj%2C+Michal%3BMazej%2C+Darja%3BTratnik%2C+Janja+Snoj%3BHuetos%2C+Olga%3BL%C3%B3pez%2C+Ana%3BBerglund%2C+Marika%3BLarsson%2C+Kristin%3BSepai%2C+Ovnair&rft.aulast=Exley&rft.aufirst=Karen&rft.date=2015-08-01&rft.volume=141&rft.issue=&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2014.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-05 N1 - Date created - 2015-08-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envres.2014.12.003 ER - TY - JOUR T1 - Antipsychotic Cardiometabolic Side Effect Monitoring in a State Community Mental Health System AN - 1704939090 AB - Antipsychotic medications can cause serious cardiometabolic side effects. No recent research has broadly evaluated monitoring and strategies to improve monitoring in U.S. public mental health systems. To address this knowledge gap, we evaluated education with audit and feedback to leaders to improve cardiometabolic monitoring in a state mental health system. We used Chi square statistics and logistic regressions to explore changes in monitoring recorded in randomly sampled records over 2 years. In 2009, assessment of patients on antipsychotics was 29.6 % for cholesterol, 40.4 % for glucose, 29.1 % for triglycerides, 54.3 % for weight, 33.6 % for blood pressure, and 5.7 % for abdominal girth. In 2010, four of ten mental health centers improved their rate of adult laboratory monitoring. Overall monitoring in the state did not increase. Education for prescribers with audit and feedback to leaders can improve monitoring in some settings, but more intensive and/or prolonged interventions may be required. JF - Community Mental Health Journal AU - Nesnera, Alex AU - Kelly, Michael AU - Orsini, Karen AU - Xie, Haiyi AU - McHugo, Greg AU - Bartels, Stephen AU - Brunette, Mary F AD - Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA ; Bureau of Behavioral Health, Department of Health and Human Services, Hanover, NH, USA ; Department of Psychiatry, Geisel School of Medicine at Dartmouth, Hanover, NH, USA, Bureau of Behavioral Health, Department of Health and Human Services, Hanover, NH, USA ; Cotes, Robert O; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 80 Jesse Hill Jr Dr SE, Atlanta, GA, 30303, USA Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 685 EP - 694 CY - New York PB - Springer Science & Business Media VL - 51 IS - 6 SN - 0010-3853 KW - Psychology KW - Blood Pressure KW - Health Care Services KW - Public Health KW - Health KW - Community Mental Health KW - Mental Health KW - Knowledge KW - Patients KW - Health care KW - Audits KW - Intensive care KW - Side effects KW - Antipsychotic drugs KW - Interventions KW - Feedback KW - Community mental health services KW - Blood pressure KW - Mental health services KW - Glucose KW - Cholesterol KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704939090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Antipsychotic+Cardiometabolic+Side+Effect+Monitoring+in+a+State+Community+Mental+Health+System&rft.au=Cotes%2C+Robert+O%3BNesnera%2C+Alex%3BKelly%2C+Michael%3BOrsini%2C+Karen%3BXie%2C+Haiyi%3BMcHugo%2C+Greg%3BBartels%2C+Stephen%3BBrunette%2C+Mary+F&rft.aulast=Cotes&rft.aufirst=Robert&rft.date=2015-08-01&rft.volume=51&rft.issue=6&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-015-9833-0 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Social Services Abstracts N1 - Date revised - 2015-08-18 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1007/s10597-015-9833-0 ER - TY - JOUR T1 - Sexualized behaviors partially mediate the link between maltreatment and delinquent behaviors AN - 1704341468; 4694849 AB - The link between child maltreatment and juvenile delinquency has been well established, yet the underlying mechanisms through which the relationship may be explained are not very well understood. Although sexualized behaviors have been most studied in the context of sexual abuse, increasing evidence suggests that a broader conceptualization is warranted. Therefore, the current study tested sexualized behaviors as a mediator in the relation between child maltreatment of any type and delinquent behaviors using structural equation modeling. This study used a multi-site prospective sample of 804 children who were at high-risk for experiencing maltreatment and part of the Longitudinal Studies of Child Abuse and Neglect consortium. This study found that reported maltreatment was related to delinquency, and sexualized behaviors partially mediated the relationship between child maltreatment and juvenile delinquency. Specifically, children with more maltreatment reports before age 8 had increased sexualized behaviors at age 8, which in turn predicted greater delinquent behaviors at age 12. These results suggest that in addition to maltreatment experiences, early sexualized behaviors (i.e., at age 8) may also be markers for subsequent delinquent behaviors (i.e., at age 12). Researchers and clinicians should work to further clarify the connections among child maltreatment, sexualized behaviors, and delinquency. Reprinted by permission of Springer JF - Journal of child and family studies AU - Merrick, Melissa T AU - Litrownik, Alan J AU - Margolis, Benyamin AU - Wiley, Tisha R.A. AU - Everson, Mark D AU - Dubowitz, Howard AU - English, Diana AD - National Center for Injury Prevention and Control ; San Diego State University ; Health Resources and Services Administration ; National Institutes of Health ; University of North Carolina, Chapel Hill ; University of Maryland ; University of Washington Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2217 EP - 2228 VL - 24 IS - 8 SN - 1062-1024, 1062-1024 KW - Sociology KW - Sexuality KW - Sexual behaviour KW - Conceptualization KW - Juvenile delinquency KW - Mediation KW - Modelling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704341468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+family+studies&rft.atitle=Sexualized+behaviors+partially+mediate+the+link+between+maltreatment+and+delinquent+behaviors&rft.au=Merrick%2C+Melissa+T%3BLitrownik%2C+Alan+J%3BMargolis%2C+Benyamin%3BWiley%2C+Tisha+R.A.%3BEverson%2C+Mark+D%3BDubowitz%2C+Howard%3BEnglish%2C+Diana&rft.aulast=Merrick&rft.aufirst=Melissa&rft.date=2015-08-01&rft.volume=24&rft.issue=8&rft.spage=2217&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+family+studies&rft.issn=10621024&rft_id=info:doi/10.1007%2Fs10826-014-0024-3 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - 7039 3364 11893 11979; 7869 2703 2698; 11563 1025 1542 11325 6071; 2688 2449 10404; 8162 8163; 11579 11538 DO - http://dx.doi.org/10.1007/s10826-014-0024-3 ER - TY - JOUR T1 - Sexualized Behaviors Partially Mediate the Link between Maltreatment and Delinquent Behaviors AN - 1703894193 AB - The link between child maltreatment and juvenile delinquency has been well established, yet the underlying mechanisms through which the relationship may be explained are not very well understood. Although sexualized behaviors have been most studied in the context of sexual abuse, increasing evidence suggests that a broader conceptualization is warranted. Therefore, the current study tested sexualized behaviors as a mediator in the relation between child maltreatment of any type and delinquent behaviors using structural equation modeling. This study used a multi-site prospective sample of 804 children who were at high-risk for experiencing maltreatment and part of the Longitudinal Studies of Child Abuse and Neglect consortium. This study found that reported maltreatment was related to delinquency, and sexualized behaviors partially mediated the relationship between child maltreatment and juvenile delinquency. Specifically, children with more maltreatment reports before age 8 had increased sexualized behaviors at age 8, which in turn predicted greater delinquent behaviors at age 12. These results suggest that in addition to maltreatment experiences, early sexualized behaviors (i.e., at age 8) may also be markers for subsequent delinquent behaviors (i.e., at age 12). Researchers and clinicians should work to further clarify the connections among child maltreatment, sexualized behaviors, and delinquency. JF - Journal of Child and Family Studies AU - Litrownik, Alan J AU - Margolis, Benyamin AU - Wiley, Tisha R A AU - Everson, Mark D AU - Dubowitz, Howard AU - English, Diana AD - Department of Psychology, San Diego State University, San Diego, CA, USA ; Division of Home Visiting and Early Childhood Systems, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, USA ; Office of Behavioral and Social Science Research, National Institutes of Health, Bethesda, MD, USA ; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA ; Department of Pediatrics, University of Maryland, College Park, MD, USA ; School of Social Work, University of Washington, Seattle, WA, USA ; Merrick, Melissa T; Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, GA, USA Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2217 EP - 2228 CY - New York PB - Springer Science & Business Media VL - 24 IS - 8 SN - 1062-1024 KW - Psychology KW - Juvenile Delinquency KW - Child neglect KW - Maltreated children KW - Maltreatment KW - Sexual abuse KW - Children KW - Child Neglect KW - Child Sexual Abuse KW - Risk KW - Abused children KW - Age KW - Behaviour KW - Child abuse KW - Child maltreatment KW - Conceptualization KW - Delinquency KW - High risk KW - Juvenile offenders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703894193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+and+Family+Studies&rft.atitle=Sexualized+Behaviors+Partially+Mediate+the+Link+between+Maltreatment+and+Delinquent+Behaviors&rft.au=Merrick%2C+Melissa+T%3BLitrownik%2C+Alan+J%3BMargolis%2C+Benyamin%3BWiley%2C+Tisha+R+A%3BEverson%2C+Mark+D%3BDubowitz%2C+Howard%3BEnglish%2C+Diana&rft.aulast=Merrick&rft.aufirst=Melissa&rft.date=2015-08-01&rft.volume=24&rft.issue=8&rft.spage=2217&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+and+Family+Studies&rft.issn=10621024&rft_id=info:doi/10.1007%2Fs10826-014-0024-3 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-08-13 N1 - Last updated - 2016-05-16 DO - http://dx.doi.org/10.1007/s10826-014-0024-3 ER - TY - JOUR T1 - Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury. AN - 1701892321; 25932872 AB - Identification of signaling pathways that are functional in a specific biological context is a major challenge in systems biology, and could be instrumental to the study of complex diseases and various aspects of drug discovery. Recent approaches have attempted to combine gene expression data with prior knowledge of protein connectivity in the form of a PPI network, and employ computational methods to identify subsets of the protein-protein-interaction (PPI) network that are functional, based on the data at hand. However, the use of undirected networks limits the mechanistic insight that can be drawn, since it does not allow for following mechanistically signal transduction from one node to the next. To address this important issue, we used a directed, signaling network as a scaffold to represent protein connectivity, and implemented an Integer Linear Programming (ILP) formulation to model the rules of signal transduction from one node to the next in the network. We then optimized the structure of the network to best fit the gene expression data at hand. We illustrated the utility of ILP modeling with a case study of drug induced lung injury. We identified the modes of action of 200 lung toxic drugs based on their gene expression profiles and, subsequently, merged the drug specific pathways to construct a signaling network that captured the mechanisms underlying Drug Induced Lung Disease (DILD). We further demonstrated the predictive power and biological relevance of the DILD network by applying it to identify drugs with relevant pharmacological mechanisms for treating lung injury. JF - Integrative biology : quantitative biosciences from nano to macro AU - Melas, Ioannis N AU - Sakellaropoulos, Theodore AU - Iorio, Francesco AU - Alexopoulos, Leonidas G AU - Loh, Wei-Yin AU - Lauffenburger, Douglas A AU - Saez-Rodriguez, Julio AU - Bai, Jane P F AD - Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA. jane.bai@fda.hhs.gov. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 904 EP - 920 VL - 7 IS - 8 KW - Proteome KW - 0 KW - Index Medicus KW - Humans KW - Signal Transduction -- drug effects KW - Drug-Related Side Effects and Adverse Reactions -- etiology KW - Protein Interaction Mapping -- methods KW - Drug-Related Side Effects and Adverse Reactions -- metabolism KW - Metabolic Networks and Pathways -- drug effects KW - Lung Injury -- metabolism KW - Lung Injury -- chemically induced KW - Proteome -- metabolism KW - Lung -- drug effects KW - Lung -- metabolism KW - Models, Biological KW - Gene Expression Profiling -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701892321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Integrative+biology+%3A+quantitative+biosciences+from+nano+to+macro&rft.atitle=Identification+of+drug-specific+pathways+based+on+gene+expression+data%3A+application+to+drug+induced+lung+injury.&rft.au=Melas%2C+Ioannis+N%3BSakellaropoulos%2C+Theodore%3BIorio%2C+Francesco%3BAlexopoulos%2C+Leonidas+G%3BLoh%2C+Wei-Yin%3BLauffenburger%2C+Douglas+A%3BSaez-Rodriguez%2C+Julio%3BBai%2C+Jane+P+F&rft.aulast=Melas&rft.aufirst=Ioannis&rft.date=2015-08-01&rft.volume=7&rft.issue=8&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Integrative+biology+%3A+quantitative+biosciences+from+nano+to+macro&rft.issn=1757-9708&rft_id=info:doi/10.1039%2Fc4ib00294f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-02 N1 - Date created - 2015-08-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1039/c4ib00294f ER - TY - JOUR T1 - Chemometric Model Development and Comparison of Raman and super(13)C Solid-State Nuclear Magnetic Resonance-Chemometric Methods for Quantification of Crystalline/Amorphous Warfarin Sodium Fraction in the Formulations AN - 1701504269; PQ0001762012 AB - Warfarin sodium (WS) exists in multiple solid-state forms. The solid-state forms differ in physicochemical properties, and crystalline changes in the drug formulation may influence on the drug product quality and/or clinical performance. It is, therefore, critically important to have a good and reliable analytical method to monitor and quantitate this transformation during stability studies. The aim of the present research was to investigate Raman spectroscopy and solid-state nuclear magnetic resonance ( super(13)C ssNMR) methods in conjunction with chemometry to quantitate the amorphous and crystalline WS fractions in the drug products. Compositionally identical formulations of amorphous and crystalline WS were prepared, and mixed in various proportions to make 0%-100% amorphous/crystalline sample matrices. Raman and super(13)C ssNMR spectra were collected and subjected to partial-least-squares and principle component regressions after mathematical treatment of the data. The model performance parameters such as root-mean-square error of prediction, standard error of prediction, and bias were low for Raman models in comparison to super(13)C ssNMR models. Models predicted values of the independent sample matrices match closely with the actual values at high level of crystalline WS. Thus, the developed methods provide means to control and quantitate the WS forms fraction in the drug product. 104:2550-2558, 2015 JF - Journal of Pharmaceutical Sciences AU - Rahman, Ziyaur AU - Mohammad, Adil AU - Akhtar, Sohail AU - Siddiqui, Akhtar AU - Korang-Yeboah, Maxwell AU - Khan, Mansoor A AD - Division of Product Quality and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland. Y1 - 2015/08// PY - 2015 DA - Aug 2015 SP - 2550 EP - 2558 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 8 SN - 0022-3549, 0022-3549 KW - Toxicology Abstracts KW - Sodium KW - Transformation KW - Raman spectroscopy KW - Mathematical models KW - Data processing KW - Physicochemical properties KW - N.M.R. KW - Warfarin KW - Drugs KW - Models KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701504269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Chemometric+Model+Development+and+Comparison+of+Raman+and+super%2813%29C+Solid-State+Nuclear+Magnetic+Resonance-Chemometric+Methods+for+Quantification+of+Crystalline%2FAmorphous+Warfarin+Sodium+Fraction+in+the+Formulations&rft.au=Rahman%2C+Ziyaur%3BMohammad%2C+Adil%3BAkhtar%2C+Sohail%3BSiddiqui%2C+Akhtar%3BKorang-Yeboah%2C+Maxwell%3BKhan%2C+Mansoor+A&rft.aulast=Rahman&rft.aufirst=Ziyaur&rft.date=2015-08-01&rft.volume=104&rft.issue=8&rft.spage=2550&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24524 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Transformation; Sodium; Raman spectroscopy; Data processing; Mathematical models; Physicochemical properties; N.M.R.; Warfarin; Drugs; Models DO - http://dx.doi.org/10.1002/jps.24524 ER - TY - JOUR T1 - Chemoprophylaxis and vaccination in preventing subsequent cases of meningococcal disease in household contacts of a case of meningococcal disease: a systematic review AN - 1701502233; PQ0001725286 AB - Household contacts of an index case of invasive meningococcal disease (IMD) are at increased risk of acquiring disease. In revising WHO guidance on IMD in sub-Saharan Africa, a systematic review was undertaken to assess the effect of chemoprophylaxis and of vaccination in preventing subsequent cases of IMD in household contacts following an index case. A literature search for systematic reviews identified a single suitable review on chemoprophylaxis in 2004 (three studies meta-analysed). A search for primary research papers published since 2004 on chemoprophylaxis and without a date limit on vaccination was therefore undertaken. There were 2381 studies identified of which two additional studies met the inclusion criteria. The summary risk ratio for chemoprophylaxis vs. no chemoprophylaxis (four studies) in the 30-day period after a case was 0.16 [95% confidence interval (CI) 0.04-0.64, P = 0.008]; the number needed to treat to prevent one subsequent case was 200 (95% CI 111-1000). A single quasi-randomized trial assessed the role of vaccination. The risk ratio for vaccination vs. no vaccination at 30 days was 0.11 (95% CI 0.01-2.07, P = 0.14). The results support the use of chemoprophylaxis to prevent subsequent cases of IMD in household contacts of a case. Conclusions about the use of vaccination could not be drawn. JF - Epidemiology and Infection AU - TELISINGHE, L AU - Waite, T D AU - Gobin, M AU - Ronveaux, O AU - Fernandez, K AU - Stuart, J M AU - SCHOLTEN, RJPM AD - Field Epidemiology Services, Public Health England, Bristol, UK, lily.telisinghe@phe.gov.uk Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 2259 EP - 2268 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 11 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Risk assessment KW - meningococcal disease KW - Reviews KW - Invasive meningococcal disease KW - Africa KW - Neisseria meningitidis KW - Vaccines KW - Vaccination KW - J 02310:Genetics & Taxonomy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701502233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Chemoprophylaxis+and+vaccination+in+preventing+subsequent+cases+of+meningococcal+disease+in+household+contacts+of+a+case+of+meningococcal+disease%3A+a+systematic+review&rft.au=TELISINGHE%2C+L%3BWaite%2C+T+D%3BGobin%2C+M%3BRonveaux%2C+O%3BFernandez%2C+K%3BStuart%2C+J+M%3BSCHOLTEN%2C+RJPM&rft.aulast=TELISINGHE&rft.aufirst=L&rft.date=2015-08-01&rft.volume=143&rft.issue=11&rft.spage=2259&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268815000849 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 28 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - meningococcal disease; Invasive meningococcal disease; Vaccination; Risk assessment; Reviews; Vaccines; Neisseria meningitidis; Africa DO - http://dx.doi.org/10.1017/S0950268815000849 ER - TY - JOUR T1 - Quantification of Kras mutant fraction in the lung DNA of mice exposed to aerosolized particulate vanadium pentoxide by inhalation. AN - 1701310706; 26232258 AB - This study investigated whether Kras mutation is an early event in the development of lung tumors induced by inhalation of particulate vanadium pentoxide (VP) aerosols. A National Toxicology Program tumor bioassay of inhaled particulate VP aerosols established that VP-induced alveolar/bronchiolar carcinomas of the B6C3F1 mouse lung carried Kras mutations at a higher frequency than observed in spontaneous mouse lung tumors. Therefore, this study sought to: (1) characterize any Kras mutational response with respect to VP exposure concentration, and (2) investigate the possibility that amplification of preexisting Kras mutation is an early event in VP-induced mouse lung tumorigenesis. Male Big Blue B6C3F1 mice (6 mice/group) were exposed to aerosolized particulate VP by inhalation, 6h/day, 5 days/week for 4 or 8 weeks, using VP exposure concentrations of 0, 0.1, and 1 mg/m(3). The levels of two different Kras codon 12 mutations [GGT → GAT (G12D) and GGT → GTT (G12V)] were measured in lung DNAs by Allele-specific Competitive Blocker PCR (ACB-PCR). For both exposure concentrations (0.1 and 1.0mg/m(3)) and both time points (4 and 8 weeks), the mutant fractions observed in VP-exposed mice were not significantly different from the concurrent controls. Given that 8 weeks of inhalation of a tumorigenic concentration of particulate aerosols of VP did not result in a significant change in levels of lung Kras mutation, the data do not support either a direct genotoxic effect of VP on Kras or early amplification of preexisting mutation as being involved in the genesis of VP-induced mouse lung tumors under the exposure conditions used. Rather, the data suggest that accumulation of Kras mutation occurs later with chronic VP exposure and is likely not an early event in VP-induced mouse lung carcinogenesis. Published by Elsevier B.V. JF - Mutation research. Genetic toxicology and environmental mutagenesis AU - Banda, Malathi AU - McKim, Karen L AU - Haber, Lynne T AU - MacGregor, Judith A AU - Gollapudi, B Bhaskar AU - Parsons, Barbara L AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, United States. ; Toxicology Excellence for Risk Assessment, Cincinnati, OH, United States. ; Toxicology Consulting Services, Bonita Springs, FL, United States. ; Exponent, Midland, MI, United States. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, US FDA, Jefferson, AR, United States. Electronic address: barbara.parsons@fda.hhs.gov. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 53 EP - 60 VL - 789-790 KW - Aerosols KW - 0 KW - Codon KW - Particulate Matter KW - Vanadium Compounds KW - vanadium pentoxide KW - BVG363OH7A KW - Kras2 protein, mouse KW - EC 3.6.5.2 KW - Proto-Oncogene Proteins p21(ras) KW - Index Medicus KW - Vanadium pentoxide KW - Carcinogenesis KW - Mode of action KW - Mutation KW - Animals KW - Codon -- genetics KW - Aerosols -- toxicity KW - Dose-Response Relationship, Drug KW - DNA Mutational Analysis -- methods KW - Mice, Transgenic KW - Particulate Matter -- toxicity KW - Mutagenicity Tests KW - Carcinogenesis -- genetics KW - Particulate Matter -- administration & dosage KW - Aerosols -- administration & dosage KW - Polymerase Chain Reaction -- methods KW - Carcinogenesis -- drug effects KW - Lung Neoplasms -- genetics KW - Lung Neoplasms -- chemically induced KW - Administration, Inhalation KW - Time Factors KW - Male KW - Mutation -- drug effects KW - Vanadium Compounds -- toxicity KW - Lung -- drug effects KW - Vanadium Compounds -- administration & dosage KW - Lung -- pathology KW - Lung -- metabolism KW - Proto-Oncogene Proteins p21(ras) -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701310706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research.+Genetic+toxicology+and+environmental+mutagenesis&rft.atitle=Quantification+of+Kras+mutant+fraction+in+the+lung+DNA+of+mice+exposed+to+aerosolized+particulate+vanadium+pentoxide+by+inhalation.&rft.au=Banda%2C+Malathi%3BMcKim%2C+Karen+L%3BHaber%2C+Lynne+T%3BMacGregor%2C+Judith+A%3BGollapudi%2C+B+Bhaskar%3BParsons%2C+Barbara+L&rft.aulast=Banda&rft.aufirst=Malathi&rft.date=2015-08-01&rft.volume=789-790&rft.issue=&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Mutation+research.+Genetic+toxicology+and+environmental+mutagenesis&rft.issn=1879-3592&rft_id=info:doi/10.1016%2Fj.mrgentox.2015.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-26 N1 - Date created - 2015-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.mrgentox.2015.07.003 ER - TY - JOUR T1 - Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks. AN - 1701300641; 26232257 AB - Chronic inhalation of vanadium pentoxide (V2O5) increases the incidence of alveolar/bronchiolar tumors in male and female B6C3F1 mice at 1, 2, or 4 mg/m(3). The genotoxicity of V2O5 has been extensively investigated in the literature with mixed results. In general, tests for gene mutations have been negative. Both positive and negative results were reported for clastogenicity in vitro with some reports suggesting aneugenic potential. In vivo, V2O5 was negative in the mouse micronucleus test (erythrocyte) and comet assay (lung). Previously, K-ras mutations have been detected in the lung tumors in mice exposed to V2O5. Recently, a short-term inhalation study in B6C3F1 mice reported slight induction of 8-oxodGuo DNA lesions in lungs. Because 8-oxodGuo DNA lesions can lead to gene mutations if not repaired or if misrepaired, we have used groups of transgenic Big Blue (BB) mice (B6C3F1) to test whether V2O5 has mutagenic potential in vivo in the tumor target tissue under the conditions of the bioassay. Groups of six male BB mice were exposed to particulate aerosols containing 0, 0.1, or 1 mg/m(3) (tumorigenic concentration) V2O5 for 4 or 8 weeks (6h/day, 5 days/week) and cII mutant frequencies (MFs) were evaluated in the right lungs. A significant increase in lung weight was noted in mice exposed to 1 mg/m(3) V2O5 (P ≤ 0.05) compared to sham control, confirming exposure to an inflammatory level of the test material. The mean MFs (× 10(-6)) of mice in the 4-week exposure groups were 30 (sham control), 39 (0.1 mg/m(3)), and 24 (1 mg/m(3)) while the corresponding values in the 8-week exposure groups were 29, 48, and 17, respectively. None of these cII MFs measured at any time point was significantly higher than the corresponding control MFs (P ≥ 0.1). Overall, these results suggest that mutagenicity is not likely to be an initial key event in the lung tumorigenicity of V2O5. Published by Elsevier B.V. JF - Mutation research. Genetic toxicology and environmental mutagenesis AU - Manjanatha, Mugimane G AU - Shelton, Sharon D AU - Haber, Lynne AU - Gollapudi, Bhaskar AU - MacGregor, Judith A AU - Rajendran, Narayanan AU - Moore, Martha M AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, USFDA, Jefferson, AR, United States. Electronic address: Mugimane.manjanatha@fda.hhs.gov. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, USFDA, Jefferson, AR, United States. ; Toxicological Excellence for Risk Assessment, Cincinnati, OH, United States. ; Center for Toxicology and Mechanistic Biology, Exponent Inc., Midland, MI, United States. ; Toxicology Consulting Services, Bonita Springs, FL, United States. ; IIT Research Institute, Chicago, IL, United States. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 46 EP - 52 VL - 789-790 KW - Transcription Factors KW - 0 KW - Vanadium Compounds KW - Viral Proteins KW - cII protein, bacteriophage lambda KW - vanadium pentoxide KW - BVG363OH7A KW - Index Medicus KW - Mutagenic mode of action for the carcinogenicity of vanadium pentoxide KW - Vanadium pentoxide mutagenicity in lungs by inhalation study KW - cII mutagenicity in Big Blue mice KW - Animals KW - Mutagenicity Tests KW - Dose-Response Relationship, Drug KW - DNA Mutational Analysis KW - Lung Neoplasms -- genetics KW - Lung Neoplasms -- chemically induced KW - Mice, Transgenic KW - Administration, Inhalation KW - Time Factors KW - Male KW - Organ Size -- drug effects KW - Viral Proteins -- genetics KW - Mutation -- drug effects KW - Vanadium Compounds -- toxicity KW - Lung -- drug effects KW - Vanadium Compounds -- administration & dosage KW - Lung -- pathology KW - Lung -- metabolism KW - Transcription Factors -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701300641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research.+Genetic+toxicology+and+environmental+mutagenesis&rft.atitle=Evaluation+of+cII+mutations+in+lung+of+male+Big+Blue+mice+exposed+by+inhalation+to+vanadium+pentoxide+for+up+to+8+weeks.&rft.au=Manjanatha%2C+Mugimane+G%3BShelton%2C+Sharon+D%3BHaber%2C+Lynne%3BGollapudi%2C+Bhaskar%3BMacGregor%2C+Judith+A%3BRajendran%2C+Narayanan%3BMoore%2C+Martha+M&rft.aulast=Manjanatha&rft.aufirst=Mugimane&rft.date=2015-08-01&rft.volume=789-790&rft.issue=&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Mutation+research.+Genetic+toxicology+and+environmental+mutagenesis&rft.issn=1879-3592&rft_id=info:doi/10.1016%2Fj.mrgentox.2015.06.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-26 N1 - Date created - 2015-08-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.mrgentox.2015.06.014 ER - TY - CONF T1 - Current Research and Opportunities to Address Environmental Asbestos Exposures. AN - 1701300214; 26230287 AB - Asbestos-related diseases continue to result in approximately 120,000 deaths every year in the United States and worldwide. Although extensive research has been conducted on health effects of occupational exposures to asbestos, many issues related to environmental asbestos exposures remain unresolved. For example, environmental asbestos exposures associated with a former mine in Libby, Montana, have resulted in high rates of nonoccupational asbestos-related disease. Additionally, other areas with naturally occurring asbestos deposits near communities in the United States and overseas are undergoing investigations to assess exposures and potential health risks. Some of the latest public health, epidemiological, and basic research findings were presented at a workshop on asbestos at the 2014 annual meeting of the Society of Toxicology in Phoenix, Arizona. The following focus areas were discussed: a) mechanisms resulting in fibrosis and/or tumor development; b) relative toxicity of different forms of asbestos and other hazardous elongated mineral particles (EMPs); c) proper dose metrics (e.g., mass, fiber number, or surface area of fibers) when interpreting asbestos toxicity; d) asbestos exposure to susceptible populations; and e) using toxicological findings for risk assessment and remediation efforts. The workshop also featured asbestos research supported by the National Institute of Environmental Health Sciences, the Agency for Toxic Substances and Disease Registry, and the U.S. Environmental Protection Agency. Better protection of individuals from asbestos-related health effects will require stimulation of new multidisciplinary research to further our understanding of what constitutes hazardous exposures and risk factors associated with toxicity of asbestos and other hazardous EMPs (e.g., nanomaterials). JF - Environmental health perspectives AU - Carlin, Danielle J AU - Larson, Theodore C AU - Pfau, Jean C AU - Gavett, Stephen H AU - Shukla, Arti AU - Miller, Aubrey AU - Hines, Ronald Y1 - 2015/08// PY - 2015 DA - August 2015 SP - A194 EP - A197 VL - 123 IS - 8 KW - Environmental Pollutants KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Humans KW - Environmental Restoration and Remediation KW - Risk Assessment KW - Environmental Pollutants -- toxicity KW - Environmental Exposure KW - Asbestos -- toxicity KW - Asbestosis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701300214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Environmental+health+perspectives&rft.atitle=Current+Research+and+Opportunities+to+Address+Environmental+Asbestos+Exposures.&rft.au=Carlin%2C+Danielle+J%3BLarson%2C+Theodore+C%3BPfau%2C+Jean+C%3BGavett%2C+Stephen+H%3BShukla%2C+Arti%3BMiller%2C+Aubrey%3BHines%2C+Ronald&rft.aulast=Carlin&rft.aufirst=Danielle&rft.date=2015-08-01&rft.volume=123&rft.issue=8&rft.spage=A194&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1409662 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-17 N1 - Date created - 2015-08-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health. 2014;13:59 [25043725] J Toxicol Environ Health A. 2015;78(3):151-65 [25506632] J Occup Environ Med. 2015 Jan;57(1):6-13 [25563535] Occup Environ Med. 2015 Mar;72(3):216-8 [25231672] Am J Ind Med. 2015 May;58(5):494-508 [25675894] J Thorac Oncol. 2015 May;10(5):731-7 [25668121] Curr Probl Diagn Radiol. 2015 Jul-Aug;44(4):371-82 [25444537] Arthritis Rheum. 2002 Jun;46(6):1602-13 [12115192] Mol Cell. 2002 Aug;10(2):417-26 [12191486] Environ Health Perspect. 2003 Nov;111(14):1753-9 [14594627] Am J Ind Med. 2014 Nov;57(11):1197-206 [24898907] Am J Respir Crit Care Med. 2004 Sep 15;170(6):691-715 [15355871] Am Rev Respir Dis. 1984 Jun;129(6):952-8 [6329050] Occup Environ Med. 1997 Sep;54(9):646-52 [9423577] Environ Health Perspect. 2005 Jan;113(1):25-30 [15626643] Environ Health Perspect. 2006 Aug;114(8):1243-7 [16882533] Am J Respir Crit Care Med. 2008 Mar 15;177(6):630-7 [18063841] Science. 2008 May 2;320(5876):674-7 [18403674] Am J Ind Med. 2008 Nov;51(11):877-80 [18651576] Radiology. 2010 Jun;255(3):924-33 [20501730] Environ Health Perspect. 2010 Jul;118(7):1033-28 [20332072] Environ Health Perspect. 2010 Jul;118(7):897-901 [20601329] Environ Health Perspect. 2010 Jul;118(7):A298-303 [20601321] Int J Occup Environ Health. 2010 Jul-Sep;16(3):279-90 [20662420] Toxicol Sci. 2010 Dec;118(2):420-34 [20855422] Inhal Toxicol. 2011 Feb;23(3):129-41 [21391781] J Immunotoxicol. 2011 Jun;8(2):159-69 [21457077] Inhal Toxicol. 2011 May;23(6):313-23 [21605006] J Toxicol Environ Health A. 2011;74(17):1111-32 [21797767] Proc Natl Acad Sci U S A. 2011 Aug 16;108(33):13618-23 [21788493] Environ Health Perspect. 2011 Dec;119(12):1806-10 [21807578] Toxicol Lett. 2012 Jan 25;208(2):168-73 [22085844] Environ Health Perspect. 2012 Jan;120(1):85-91 [21979745] J Toxicol Environ Health A. 2012;75(3):183-200 [22251266] Toxicol Sci. 2012 Dec;130(2):405-15 [22903825] Am J Ind Med. 2013 Feb;56(2):133-45 [22886909] Int J Cancer. 2013 Mar 15;132(6):1423-8 [22858896] Environ Geochem Health. 2013 Aug;35(4):419-30 [23315055] Part Fibre Toxicol. 2013;10:39 [23937860] Inhal Toxicol. 2013 Dec;25(14):774-84 [24304304] Part Fibre Toxicol. 2014;11:2 [24401117] Toxicol Appl Pharmacol. 2014 Mar 15;275(3):257-64 [24518925] Part Fibre Toxicol. 2014;11:24 [24885895] J Immunotoxicol. 2014 Jul-Sep;11(3):283-90 [24164284] J Expo Sci Environ Epidemiol. 2015 Jan;25(1):4-11 [23695492] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1409662 ER - TY - JOUR T1 - Effect of Fill Temperature on Clostridium botulinum Type A Toxin Activity during the Hot Filling of Juice Bottles. AN - 1700335894; 26219364 AB - The potential threat of terrorist attacks against the United States food supply using neurotoxin produced by Clostridium botulinum (BoNT) has resulted in the need for studying the effect of various food process operations on the bioavailability of this toxin. The objective of this study was to evaluate C. botulinum type A neurotoxin bioavailability after a simulated hot fill juice bottling operation. C. botulinum type A acid mud toxin (∼10(6) mouse lethal dose [MLD50]/ml) was deposited into juice bottles at an experimentally determined fastest cooling spot. Bottles (12 or 20 oz [355 and 592 ml]) were filled with either apple juice or an orange drink, at 80 or 85°C, in either upright or inverted orientations. Toxicity of the juice was evaluated as a function of holding time (1 to 2 min) by the mouse bioassay. The fastest cooling point in the upright orientation was determined to be at a bottle's bottom rim. In the inverted orientation, the fastest cooling point was in the bottle cap region. With respect to these two points, the upright bottle cooled faster than the inverted bottle, which was reflected in a higher inactivation of BoNT in the latter. For the orange drink (pH 2.9) toxicity was reduced by 0.5 × 10(6) MLD50/ml to a nondetectable level after 1 min in all bottle sizes, orientations, and temperatures as measured by the mouse bioassay. This indicates that there was at least a 0.5 × 10(6) MLD50/ml reduction in activity. Inactivation in apple juice (pH 4.0), to the same degree as in the orange drink, was found only for the inverted orientation at 85°C. Complete inactivation in apple juice for all conditions was found at a lower added toxin level of 0.25 × 10(5) MLD50/ml. In general, bottle inversion and filling at 85°C provided complete inactivation of BoNT to the 0.5 × 10(6) MLD50/ml level. All experiments resulted in the inactivation of 2.5 × 10(4) MLD50/ml of BoNT regardless of juice type, fill temperature, or bottle orientation and size. JF - Journal of food protection AU - Skinner, Guy E AU - Fleischman, Gregory J AU - Balster, Fran AU - Reineke, Karl AU - Reddy, N Rukma AU - Larkin, John W AD - U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, Illinois 60501, USA; U.S. Food and Drug Administration, Institute for Food Safety and Health (IFSH), 6502 South Archer Road, Bedford Park, Illinois 60501, US. guy.skinner@fda.hhs.gov. ; U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, Illinois 60501, USA; U.S. Food and Drug Administration, Institute for Food Safety and Health (IFSH), 6502 South Archer Road, Bedford Park, Illinois 60501, US. ; Institute for Food Safety and Health (IFSH), Illinois Institute of Technology (IIT), 6502 South Archer Road, Bedford Park, Illinois 60501, USA; Illinois Department of Public Health (IFPH), 2121 Taylor Street, Chicago, IL 60612, USA. ; U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, Illinois 60501, USAU.S. Food and Drug Administration, Institute for Food Safety and Health (IFSH), 6502 South Archer Road, Bedford Park, Illinois 60501, US. ; U.S. Food and Drug Administration, 6502 South Archer Road, Bedford Park, Illinois 60501, USA; U.S. Food and Drug Administration, Institute for Food Safety and Health (IFSH), 6502 South Archer Road, Bedford Park, Illinois 60501; US National Center for Food Protection and Defense, Learning and Environmental Sciences Building, University of Minnesota, 1954 Buford Avenue, St. Paul, MN 55108, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1506 EP - 1511 VL - 78 IS - 8 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - Food Contamination -- prevention & control KW - Citrus sinensis KW - Animals KW - Food Microbiology KW - Hydrogen-Ion Concentration KW - Toxicity Tests KW - Lethal Dose 50 KW - Biological Assay KW - Malus KW - Mice KW - Hot Temperature KW - Food Handling -- methods KW - Fruit and Vegetable Juices -- microbiology KW - Clostridium botulinum type A -- isolation & purification KW - Botulinum Toxins, Type A -- analysis KW - Clostridium botulinum type A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700335894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Effect+of+Fill+Temperature+on+Clostridium+botulinum+Type+A+Toxin+Activity+during+the+Hot+Filling+of+Juice+Bottles.&rft.au=Skinner%2C+Guy+E%3BFleischman%2C+Gregory+J%3BBalster%2C+Fran%3BReineke%2C+Karl%3BReddy%2C+N+Rukma%3BLarkin%2C+John+W&rft.aulast=Skinner&rft.aufirst=Guy&rft.date=2015-08-01&rft.volume=78&rft.issue=8&rft.spage=1506&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=1944-9097&rft_id=info:doi/10.4315%2F0362-028X.JFP-14-378 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-25 N1 - Date created - 2015-07-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.4315/0362-028X.JFP-14-378 ER - TY - JOUR T1 - Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. AN - 1700333315; 26098869 AB - Pancreatic cancer is the fourth leading cause of cancer death in the developed world. Both inherited high-penetrance mutations in BRCA2 (ref. 2), ATM, PALB2 (ref. 4), BRCA1 (ref. 5), STK11 (ref. 6), CDKN2A and mismatch-repair genes and low-penetrance loci are associated with increased risk. To identify new risk loci, we performed a genome-wide association study on 9,925 pancreatic cancer cases and 11,569 controls, including 4,164 newly genotyped cases and 3,792 controls in 9 studies from North America, Central Europe and Australia. We identified three newly associated regions: 17q25.1 (LINC00673, rs11655237, odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.19-1.34, P = 1.42 × 10(-14)), 7p13 (SUGCT, rs17688601, OR = 0.88, 95% CI = 0.84-0.92, P = 1.41 × 10(-8)) and 3q29 (TP63, rs9854771, OR = 0.89, 95% CI = 0.85-0.93, P = 2.35 × 10(-8)). We detected significant association at 2p13.3 (ETAA1, rs1486134, OR = 1.14, 95% CI = 1.09-1.19, P = 3.36 × 10(-9)), a region with previous suggestive evidence in Han Chinese. We replicated previously reported associations at 9q34.2 (ABO), 13q22.1 (KLF5), 5p15.33 (TERT and CLPTM1), 13q12.2 (PDX1), 1q32.1 (NR5A2), 7q32.3 (LINC-PINT), 16q23.1 (BCAR1) and 22q12.1 (ZNRF3). Our study identifies new loci associated with pancreatic cancer risk. JF - Nature genetics AU - Childs, Erica J AU - Mocci, Evelina AU - Campa, Daniele AU - Bracci, Paige M AU - Gallinger, Steven AU - Goggins, Michael AU - Li, Donghui AU - Neale, Rachel E AU - Olson, Sara H AU - Scelo, Ghislaine AU - Amundadottir, Laufey T AU - Bamlet, William R AU - Bijlsma, Maarten F AU - Blackford, Amanda AU - Borges, Michael AU - Brennan, Paul AU - Brenner, Hermann AU - Bueno-de-Mesquita, H Bas AU - Canzian, Federico AU - Capurso, Gabriele AU - Cavestro, Giulia M AU - Chaffee, Kari G AU - Chanock, Stephen J AU - Cleary, Sean P AU - Cotterchio, Michelle AU - Foretova, Lenka AU - Fuchs, Charles AU - Funel, Niccola AU - Gazouli, Maria AU - Hassan, Manal AU - Herman, Joseph M AU - Holcatova, Ivana AU - Holly, Elizabeth A AU - Hoover, Robert N AU - Hung, Rayjean J AU - Janout, Vladimir AU - Key, Timothy J AU - Kupcinskas, Juozas AU - Kurtz, Robert C AU - Landi, Stefano AU - Lu, Lingeng AU - Malecka-Panas, Ewa AU - Mambrini, Andrea AU - Mohelnikova-Duchonova, Beatrice AU - Neoptolemos, John P AU - Oberg, Ann L AU - Orlow, Irene AU - Pasquali, Claudio AU - Pezzilli, Raffaele AU - Rizzato, Cosmeri AU - Saldia, Amethyst AU - Scarpa, Aldo AU - Stolzenberg-Solomon, Rachael Z AU - Strobel, Oliver AU - Tavano, Francesca AU - Vashist, Yogesh K AU - Vodicka, Pavel AU - Wolpin, Brian M AU - Yu, Herbert AU - Petersen, Gloria M AU - Risch, Harvey A AU - Klein, Alison P AD - Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA. ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. ; 1] Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] Department of Biology, University of Pisa, Pisa, Italy. ; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. ; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. ; Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ; Department of Population Health, QIMR Berghofer Medical Research Institute, Kelvin Grove,Queensland, Australia. ; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA. ; International Agency for Research on Cancer (IARC), Lyon, France. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, USA. ; Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. ; Laboratory for Experimental Oncology and Radiobiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. ; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. ; 1] Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands. [2] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, the Netherlands. [3] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. [4] Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. ; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. ; Digestive and Liver Disease Unit, 'Sapienza' University of Rome, Rome, Italy. ; Università Vita Salute San Raffaele and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ospedale San Raffaele, Milan, Italy. ; 1] Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada. [2] Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada. ; 1] Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada. [2] Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. ; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and Medical Faculty Masaryk University, Brno, Czech Republic. ; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. ; Department of Surgery, Unit of Experimental Surgical Pathology, University Hospital of Pisa, Pisa, Italy. ; Department of Medical Sciences, Laboratory of Biology, School of Medicine, University of Athens, Athens, Greece. ; Department of Radiation Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. ; Institute of Hygiene and Epidemiology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. ; Department of Preventive Medicine, Faculty of Medicine, Palacky University, Olomouc, Czech Republic. ; Cancer Epidemiology Unit, University of Oxford, Oxford, UK. ; Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania. ; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA. ; Department of Biology, Section of Genetics, University of Pisa, Pisa, Italy. ; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA. ; Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland. ; Department of Oncology, Azienda USL 1 Massa Carrara, Massa Carrara, Italy. ; Laboratory of Toxicogenomics, Institute of Public Health, Prague, Czech Republic. ; National Institute for Health Research (NIHR) Pancreas Biomedical Research Unit, Liverpool Clinical Trials Unit and Cancer Research UK Clinical Trials Unit, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. ; Department of Surgery, Gastroenterology and Oncology, University of Padua, Padua, Italy. ; Pancreas Unit, Department of Digestive Diseases, Sant'Orsola-Malpighi Hospital, Bologna, Italy. ; ARC-NET-Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy. ; Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA. ; Department of General Surgery, University Hospital Heidelberg, Heidelberg, Germany. ; Division of Gastroenterology and Research Laboratory, IRCCS Scientific Institute and Regional General Hospital 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Italy. ; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. ; Department of Molecular Biology of Cancer, Institute of Experimental Medicine, Academy of Sciences, Prague, Czech Republic. ; 1] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. ; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA. ; 1] Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. [2] Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 911 EP - 916 VL - 47 IS - 8 KW - Index Medicus KW - North America KW - Gene Frequency KW - Humans KW - Aged KW - Europe KW - Genome-Wide Association Study -- methods KW - Genotype KW - Risk Factors KW - Australia KW - Genetic Loci -- genetics KW - Middle Aged KW - Female KW - Male KW - Polymorphism, Single Nucleotide KW - Genetic Predisposition to Disease -- genetics KW - Chromosomes, Human, Pair 3 -- genetics KW - Pancreatic Neoplasms -- genetics KW - Chromosomes, Human, Pair 7 -- genetics KW - Chromosomes, Human, Pair 2 -- genetics KW - Chromosomes, Human, Pair 17 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700333315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+genetics&rft.atitle=Common+variation+at+2p13.3%2C+3q29%2C+7p13+and+17q25.1+associated+with+susceptibility+to+pancreatic+cancer.&rft.au=Childs%2C+Erica+J%3BMocci%2C+Evelina%3BCampa%2C+Daniele%3BBracci%2C+Paige+M%3BGallinger%2C+Steven%3BGoggins%2C+Michael%3BLi%2C+Donghui%3BNeale%2C+Rachel+E%3BOlson%2C+Sara+H%3BScelo%2C+Ghislaine%3BAmundadottir%2C+Laufey+T%3BBamlet%2C+William+R%3BBijlsma%2C+Maarten+F%3BBlackford%2C+Amanda%3BBorges%2C+Michael%3BBrennan%2C+Paul%3BBrenner%2C+Hermann%3BBueno-de-Mesquita%2C+H+Bas%3BCanzian%2C+Federico%3BCapurso%2C+Gabriele%3BCavestro%2C+Giulia+M%3BChaffee%2C+Kari+G%3BChanock%2C+Stephen+J%3BCleary%2C+Sean+P%3BCotterchio%2C+Michelle%3BForetova%2C+Lenka%3BFuchs%2C+Charles%3BFunel%2C+Niccola%3BGazouli%2C+Maria%3BHassan%2C+Manal%3BHerman%2C+Joseph+M%3BHolcatova%2C+Ivana%3BHolly%2C+Elizabeth+A%3BHoover%2C+Robert+N%3BHung%2C+Rayjean+J%3BJanout%2C+Vladimir%3BKey%2C+Timothy+J%3BKupcinskas%2C+Juozas%3BKurtz%2C+Robert+C%3BLandi%2C+Stefano%3BLu%2C+Lingeng%3BMalecka-Panas%2C+Ewa%3BMambrini%2C+Andrea%3BMohelnikova-Duchonova%2C+Beatrice%3BNeoptolemos%2C+John+P%3BOberg%2C+Ann+L%3BOrlow%2C+Irene%3BPasquali%2C+Claudio%3BPezzilli%2C+Raffaele%3BRizzato%2C+Cosmeri%3BSaldia%2C+Amethyst%3BScarpa%2C+Aldo%3BStolzenberg-Solomon%2C+Rachael+Z%3BStrobel%2C+Oliver%3BTavano%2C+Francesca%3BVashist%2C+Yogesh+K%3BVodicka%2C+Pavel%3BWolpin%2C+Brian+M%3BYu%2C+Herbert%3BPetersen%2C+Gloria+M%3BRisch%2C+Harvey+A%3BKlein%2C+Alison+P&rft.aulast=Childs&rft.aufirst=Erica&rft.date=2015-08-01&rft.volume=47&rft.issue=8&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Nature+genetics&rft.issn=1546-1718&rft_id=info:doi/10.1038%2Fng.3341 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-26 N1 - Date created - 2015-07-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Genet. 2012 Dec;44(12):1330-5 [23143601] Nat Genet. 2007 Oct;39(10):1181-6 [17898773] Nat Methods. 2013 Jan;10(1):5-6 [23269371] Dig Liver Dis. 2013 Feb;45(2):95-9 [23206934] Nature. 2013 Apr 4;496(7443):101-5 [23535601] Cancer Epidemiol. 2013 Dec;37(6):886-92 [24075798] Nucleic Acids Res. 2014 Jan;42(Database issue):D975-9 [24297256] J Inherit Metab Dis. 2014 Jan;37(1):13-9 [23893049] Hum Mol Genet. 2014 Mar 1;23(5):1387-98 [24163127] Int J Cancer. 2000 Sep 15;87(6):809-11 [10956390] J Natl Cancer Inst. 2002 Sep 18;94(18):1358-65 [12237281] J Natl Cancer Inst. 2003 Jul 2;95(13):948-60 [12837831] Cancer Res. 2004 Apr 1;64(7):2634-8 [15059921] Br J Cancer. 1985 Aug;52(2):271-3 [4027169] Mol Carcinog. 1993;8(4):214-20 [8280369] Int J Cancer. 2007 Nov 15;121(10):2241-5 [17582608] Am J Gastroenterol. 2007 Dec;102(12):2696-707 [17764494] Cancer Detect Prev. 2007;31(5):345-51 [18031948] Langenbecks Arch Surg. 2008 Jul;393(4):535-45 [18193270] Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1470-9 [18559563] Cancer Res. 2008 Jun 15;68(12):4928-35 [18544627] Science. 2009 Apr 10;324(5924):217 [19264984] Nat Genet. 2009 Sep;41(9):986-90 [19648918] J Natl Cancer Inst. 2010 Jan 20;102(2):119-26 [20068195] Eur J Cancer. 2010 Jan;46(2):370-6 [19782561] Nat Genet. 2010 Mar;42(3):224-8 [20101243] Am J Gastroenterol. 2010 Jun;105(6):1258-64; author reply 1265 [20051941] Nat Genet. 2010 Jul;42(7):579-89 [20581827] PLoS One. 2010;5(7):e11824 [20686608] Bioinformatics. 2010 Sep 1;26(17):2190-1 [20616382] Nature. 2010 Sep 2;467(7311):52-8 [20811451] Nat Genet. 2010 Oct;42(10):893-6 [20871597] Nat Genet. 2010 Nov;42(11):978-84 [20972438] Cancer Causes Control. 2011 Feb;22(2):189-97 [21104117] Am J Hum Genet. 2011 Mar 11;88(3):294-305 [21376301] Nat Rev Genet. 2010 Jul;11(7):499-511 [20517342] Cancer Res. 2011 Jul 1;71(13):4352-8 [21498636] Cell Death Differ. 2011 Sep;18(9):1487-99 [21760596] Int J Cancer. 2011 Dec 15;129(12):2875-84 [21520034] PLoS One. 2011;6(10):e26815 [22053213] Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 [22064851] Nat Genet. 2012 Jan;44(1):62-6 [22158540] Carcinogenesis. 2012 Apr;33(4):818-27 [22301281] Cancer Discov. 2012 Jan;2(1):41-6 [22585167] Carcinogenesis. 2012 Jul;33(7):1384-90 [22523087] Nat Genet. 2012 Aug;44(8):900-3 [22797724] Nat Genet. 2012 Aug;44(8):955-9 [22820512] Nature. 2012 Nov 1;491(7422):56-65 [23128226] Int J Clin Exp Pathol. 2014;7(7):4531-8 [25120849] Nat Genet. 2014 Sep;46(9):994-1000 [25086665] Bioinformatics. 2012 Dec 15;28(24):3326-8 [23060615] JAMA. 1995 May 24-31;273(20):1605-9 [7745774] Arch Intern Med. 1996 Oct 28;156(19):2255-60 [8885826] Nature. 1996 Dec 5;384(6608):455-8 [8945470] Nature. 1996 Dec 5;384(6608):458-60 [8945471] Cancer Res. 1996 Dec 1;56(23):5360-4 [8968085] J Clin Endocrinol Metab. 1999 Mar;84(3):1077-82 [10084598] Cancer Cell. 2005 Apr;7(4):363-73 [15837625] Gastroenterology. 2005 Aug;129(2):504-11 [16083707] Cancer Immunol Immunother. 2006 Apr;55(4):363-74 [16003559] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] Carcinogenesis. 2014 Dec;35(12):2670-8 [25233928] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/ng.3341 ER - TY - JOUR T1 - Quality control metrics improve repeatability and reproducibility of single-nucleotide variants derived from whole-genome sequencing. AN - 1698960809; 25384574 AB - Although many quality control (QC) methods have been developed to improve the quality of single-nucleotide variants (SNVs) in SNV-calling, QC methods for use subsequent to single-nucleotide polymorphism-calling have not been reported. We developed five QC metrics to improve the quality of SNVs using the whole-genome-sequencing data of a monozygotic twin pair from the Korean Personal Genome Project. The QC metrics improved both repeatability between the monozygotic twin pair and reproducibility between SNV-calling pipelines. We demonstrated the QC metrics improve reproducibility of SNVs derived from not only whole-genome-sequencing data but also whole-exome-sequencing data. The QC metrics are calculated based on the reference genome used in the alignment without accessing the raw and intermediate data or knowing the SNV-calling details. Therefore, the QC metrics can be easily adopted in downstream association analysis. JF - The pharmacogenomics journal AU - Zhang, W AU - Soika, V AU - Meehan, J AU - Su, Z AU - Ge, W AU - Ng, H W AU - Perkins, R AU - Simonyan, V AU - Tong, W AU - Hong, H AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. ; Office of The Center Director, Center for Biologics Evaluation and Research, US Food and Drug Administration, Rockville, MD, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 298 EP - 309 VL - 15 IS - 4 KW - Index Medicus KW - Republic of Korea KW - Base Sequence KW - Reproducibility of Results KW - Twins, Monozygotic KW - Humans KW - Algorithms KW - Quality Control KW - Chromosome Mapping KW - High-Throughput Nucleotide Sequencing KW - Genome-Wide Association Study -- standards KW - Genome, Human -- genetics KW - Polymorphism, Single Nucleotide -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698960809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+pharmacogenomics+journal&rft.atitle=Quality+control+metrics+improve+repeatability+and+reproducibility+of+single-nucleotide+variants+derived+from+whole-genome+sequencing.&rft.au=Zhang%2C+W%3BSoika%2C+V%3BMeehan%2C+J%3BSu%2C+Z%3BGe%2C+W%3BNg%2C+H+W%3BPerkins%2C+R%3BSimonyan%2C+V%3BTong%2C+W%3BHong%2C+H&rft.aulast=Zhang&rft.aufirst=W&rft.date=2015-08-01&rft.volume=15&rft.issue=4&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=The+pharmacogenomics+journal&rft.issn=1473-1150&rft_id=info:doi/10.1038%2Ftpj.2014.70 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-19 N1 - Date created - 2015-07-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/tpj.2014.70 ER - TY - JOUR T1 - Extracellular signal-regulated kinases 1/2 and Akt contribute to triclosan-stimulated proliferation of JB6 Cl 41-5a cells. AN - 1698030306; 25033989 AB - Triclosan is a broad spectrum anti-bacterial agent widely used in many personal care products, household items, medical devices, and clinical settings. Human exposure to triclosan is mainly through oral and dermal routes. In previous studies, we found that sub-chronic dermal exposure of B6C3F1 mice to triclosan induced epidermal hyperplasia and focal necrosis; however, the mechanisms for these responses remain elusive. In this study, using mouse epidermis-derived JB6 Cl 41-5a cells, we found that triclosan stimulated cell growth in a concentration- and time-dependent manner. Enhanced cell proliferation was demonstrated by a substantial increase in the percentage of BrdU-positive cells, an elevation in the protein levels of cyclin D1 and cyclin A, and a reduction in the protein level of p27(Kip1). Western blotting analysis revealed that triclosan induced the activation of extracellular signal-regulated kinases 1/2 (ERK1/2), c-Jun N-terminal kinases (JNK), p38, and Akt. Pre-treatment of the cells with PD184352, an inhibitor of the upstream kinase MEK1/2, or with wortmannin, an inhibitor of phosphoinositide 3-kinase, blocked triclosan-mediated phosphorylation of ERK1/2 and Akt, respectively, and substantially suppressed triclosan-stimulated cell proliferation, whereas the JNK inhibitor SP600125 or the p38 inhibitor SB203580 had little to no effect on triclosan-stimulated cell proliferation. The phosphorylation activation of ERK1/2 and Akt was further confirmed on the skin of mice dermally administered triclosan. These data suggest that the activation of ERK1/2 and Akt is involved in triclosan-stimulated proliferation of JB6 Cl 41-5a cells. JF - Archives of toxicology AU - Wu, Yuanfeng AU - Beland, Frederick A AU - Chen, Si AU - Fang, Jia-Long AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, 72079, USA. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 1297 EP - 1311 VL - 89 IS - 8 KW - Anti-Infective Agents, Local KW - 0 KW - Enzyme Inhibitors KW - Triclosan KW - 4NM5039Y5X KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Mitogen-Activated Protein Kinase 1 KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 3 KW - Index Medicus KW - Mice, Inbred Strains KW - Comet Assay KW - Animals KW - Blotting, Western KW - Dose-Response Relationship, Drug KW - Cell Culture Techniques KW - Enzyme Inhibitors -- pharmacology KW - Time Factors KW - Female KW - Cell Line KW - Mitogen-Activated Protein Kinase 3 -- metabolism KW - Cell Proliferation -- drug effects KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Mitogen-Activated Protein Kinase 1 -- metabolism KW - Mitogen-Activated Protein Kinase 3 -- antagonists & inhibitors KW - Apoptosis -- drug effects KW - Anti-Infective Agents, Local -- toxicity KW - Triclosan -- toxicity KW - Proto-Oncogene Proteins c-akt -- antagonists & inhibitors KW - Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698030306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Extracellular+signal-regulated+kinases+1%2F2+and+Akt+contribute+to+triclosan-stimulated+proliferation+of+JB6+Cl+41-5a+cells.&rft.au=Wu%2C+Yuanfeng%3BBeland%2C+Frederick+A%3BChen%2C+Si%3BFang%2C+Jia-Long&rft.aulast=Wu&rft.aufirst=Yuanfeng&rft.date=2015-08-01&rft.volume=89&rft.issue=8&rft.spage=1297&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-014-1308-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-15 N1 - Date created - 2015-07-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00204-014-1308-5 ER - TY - JOUR T1 - Drug-induced liver injury: Interactions between drug properties and host factors. AN - 1697759730; 25912521 AB - Idiosyncratic drug-induced liver injury (DILI) is a common cause for drug withdrawal from the market and although infrequent, DILI can result in serious clinical outcomes including acute liver failure and the need for liver transplantation. Eliminating the iatrogenic "harm" caused by a therapeutic intent is a priority in patient care. However, identifying culprit drugs and individuals at risk for DILI remains challenging. Apart from genetic factors predisposing individuals at risk, the role of the drugs' physicochemical and toxicological properties and their interactions with host and environmental factors need to be considered. The influence of these factors on mechanisms involved in DILI is multi-layered. In this review, we summarize current knowledge on 1) drug properties associated with hepatotoxicity, 2) host factors considered to modify an individuals' risk for DILI and clinical phenotypes, and 3) drug-host interactions. We aim at clarifying knowledge gaps needed to be filled in as to improve risk stratification in patient care. We therefore broadly discuss relevant areas of future research. Emerging insight will stimulate new investigational approaches to facilitate the discovery of clinical DILI risk modifiers in the context of disease complexity and associated interactions with drug properties, and hence will be able to move towards safety personalized medicine. Copyright © 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. JF - Journal of hepatology AU - Chen, Minjun AU - Suzuki, Ayako AU - Borlak, Jürgen AU - Andrade, Raúl J AU - Lucena, M Isabel AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, United States. ; Gastroenterology, Central Arkansas Veterans Healthcare System, Little Rock, AR, United States; Department of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, United States. ; Center of Pharmacology and Toxicology, Hannover Medical School, Hannover, Germany. ; Unidad de Gestión Clínica de Enfermedades Digestivas, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. Electronic address: andrade@uma.es. ; Unidad de Gestión Clínica de Enfermedades Digestivas, Servicio de Farmacología Clínica, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 503 EP - 514 VL - 63 IS - 2 KW - Index Medicus KW - Drug physicochemical properties KW - Drug clearance KW - Drug-host Interaction KW - Drug metabolism KW - Clinical toxicology KW - Host factors KW - Pharmacogenetics KW - Drug-induced liver injury KW - Risk Factors KW - Humans KW - Drug Interactions KW - Chemical and Drug Induced Liver Injury -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697759730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+hepatology&rft.atitle=Drug-induced+liver+injury%3A+Interactions+between+drug+properties+and+host+factors.&rft.au=Chen%2C+Minjun%3BSuzuki%2C+Ayako%3BBorlak%2C+J%C3%BCrgen%3BAndrade%2C+Ra%C3%BAl+J%3BLucena%2C+M+Isabel&rft.aulast=Chen&rft.aufirst=Minjun&rft.date=2015-08-01&rft.volume=63&rft.issue=2&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Journal+of+hepatology&rft.issn=1600-0641&rft_id=info:doi/10.1016%2Fj.jhep.2015.04.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-24 N1 - Date created - 2015-07-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jhep.2015.04.016 ER - TY - JOUR T1 - Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex. AN - 1697757053; 25933590 AB - Extracellular or free hemoglobin (Hb) accumulates during hemolysis, tissue damage, and inflammation. Heme-triggered oxidative reactions can lead to diverse structural modifications of lipids and proteins, which contribute to the propagation of tissue damage. One important target of Hb׳s peroxidase reactivity is its own globin structure. Amino acid oxidation and crosslinking events destabilize the protein and ultimately cause accumulation of proinflammatory and cytotoxic Hb degradation products. The Hb scavenger haptoglobin (Hp) attenuates oxidation-induced Hb degradation. In this study we show that in the presence of hydrogen peroxide (H2O2), Hb and the Hb:Hp complex share comparable peroxidative reactivity and free radical generation. While oxidation of both free Hb and Hb:Hp complex generates a common tyrosine-based free radical, the spin-trapping reaction with 5,5-dimethyl-1-pyrroline N-oxide (DMPO) yields dissimilar paramagnetic products in Hb and Hb:Hp, suggesting that radicals are differently redistributed within the complex before reacting with the spin trap. With LC-MS(2) mass spectrometry we assigned multiple known and novel DMPO adduct sites. Quantification of these adducts suggested that the Hb:Hp complex formation causes extensive delocalization of accessible free radicals with drastic reduction of the major tryptophan and cysteine modifications in the β-globin chain of the Hb:Hp complex, including decreased βCys93 DMPO adduction. In contrast, the quantitative changes in DMPO adduct formation on Hb:Hp complex formation were less pronounced in the Hb α-globin chain. In contrast to earlier speculations, we found no evidence that free Hb radicals are delocalized to the Hp chain of the complex. The observation that Hb:Hp complex formation alters free radical distribution in Hb may help to better understand the structural basis for Hp as an antioxidant protein. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Free radical biology & medicine AU - Vallelian, Florence AU - Garcia-Rubio, Ines AU - Puglia, Michele AU - Kahraman, Abdullah AU - Deuel, Jeremy W AU - Engelsberger, Wolfgang R AU - Mason, Ronald P AU - Buehler, Paul W AU - Schaer, Dominik J AD - Division of Internal Medicine, University Hospital, Zurich, Switzerland. ; Laboratory of Physical Chemistry, ETH Zürich, Switzerland; Centro Universitario de la Defensa, carretera de Huesca, Zaragoza, Spain. ; Division of Internal Medicine, University Hospital, Zurich, Switzerland; Functional Genomics Center, University of Zurich, Switzerland. ; Institute of Molecular Life Sciences, University of Zurich, Switzerland. ; Laboratory of Toxicology & Pharmacology, NIEHS/NIH, Research Triangle Park, NC, USA. ; Center of Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA. ; Division of Internal Medicine, University Hospital, Zurich, Switzerland; Institute of Evolutionary Medicine, University of Zurich, Switzerland. Electronic address: dominik.schaer@usz.ch. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 259 EP - 268 VL - 85 KW - Amino Acids KW - 0 KW - Free Radicals KW - Haptoglobins KW - Hemoglobins KW - Hydrogen Peroxide KW - BBX060AN9V KW - Peroxidases KW - EC 1.11.1.- KW - Index Medicus KW - Hemoglobin KW - Haptoglobin KW - Oxidative stress KW - Radical KW - Oxidation KW - Spin trapping KW - Electron paramagnetic resonance (EPR) KW - Mass spectrometry KW - Oxidation-Reduction KW - Amino Acids -- chemistry KW - Humans KW - Electron Spin Resonance Spectroscopy KW - Hydrogen Peroxide -- pharmacology KW - Molecular Sequence Data KW - Chromatography, Liquid KW - Amino Acid Sequence KW - Peroxidases -- metabolism KW - Spin Trapping KW - Hemoglobins -- metabolism KW - Tandem Mass Spectrometry -- methods KW - Hemoglobins -- chemistry KW - Haptoglobins -- metabolism KW - Free Radicals -- metabolism KW - Haptoglobins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697757053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Spin+trapping+combined+with+quantitative+mass+spectrometry+defines+free+radical+redistribution+within+the+oxidized+hemoglobin%3Ahaptoglobin+complex.&rft.au=Vallelian%2C+Florence%3BGarcia-Rubio%2C+Ines%3BPuglia%2C+Michele%3BKahraman%2C+Abdullah%3BDeuel%2C+Jeremy+W%3BEngelsberger%2C+Wolfgang+R%3BMason%2C+Ronald+P%3BBuehler%2C+Paul+W%3BSchaer%2C+Dominik+J&rft.aulast=Vallelian&rft.aufirst=Florence&rft.date=2015-08-01&rft.volume=85&rft.issue=&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=1873-4596&rft_id=info:doi/10.1016%2Fj.freeradbiomed.2015.04.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-26 N1 - Date created - 2015-07-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.freeradbiomed.2015.04.023 ER - TY - JOUR T1 - Prevalence of ciguatoxins in lionfish (Pterois spp.) from Guadeloupe, Saint Martin, and Saint Barthélmy Islands (Caribbean). AN - 1695757075; 26026621 AB - Lionfish (Pterois spp.) are invasive species that have recently spread throughout the Caribbean. Lionfish are available for purchase in local markets for human consumption in several islands of the region. We examined the prevalence of ciguatoxins (CTXs) in lionfish from the French Antilles, a ciguatera-endemic region. The neuroblastoma-2a (N2a) cell assay was used to assess composite cytotoxicity in 120 fish samples collected from the surrounding waters of Guadeloupe (n = 60), Saint Barthélemy Islands (n = 55) and Saint Martin (n = 5). Twenty-seven of these samples exhibited CTX-like activity by the N2a assay. Ciguatoxin (CTX) was confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in multiple samples that presented highest composite toxicity levels by N2a. Those fish found to contain CTXs were all from Saint Barthélemy. Lionfish from Guadeloupe and Saint Martin did not exhibit toxin activity, although the sample size from Saint Martin was insufficient to draw any conclusions as to the incidence of CTXs. In this study, we provide information about the potential hazard of ciguatera associated with the consumption of lionfish from known endemic areas. We also demonstrate the utility of the cell-based assay combined with LC-MS/MS to assess activity and to provide structural confirmation of CTXs respectively. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Toxicon : official journal of the International Society on Toxinology AU - Soliño, Lucía AU - Widgy, Saha AU - Pautonnier, Anthony AU - Turquet, Jean AU - Loeffler, Christopher R AU - Flores Quintana, Harold A AU - Diogène, Jorge AD - Institut de la Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou Km 5,5, Sant Carles de la Ràpita, E-43540, Spain. ; Comité Régional des Pêches Maritimes et des Élevages Marins (CRPMEM), Rue Schoelcher 2 bis, Pointe a Pitre, 97110, Guadeloupe. ; Association Réunionnaise pour le Développement de 'Aquaculture (ARDA) et ARVAM, C/o CIROY, 2, Rue Maxime Rivière, 97490, Sainte Clotilde, Reunion. ; U.S. Food and Drug Administration (FDA), Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL, 36528, USA. ; Institut de la Recerca i Tecnologia Agroalimentàries (IRTA), Ctra. Poble Nou Km 5,5, Sant Carles de la Ràpita, E-43540, Spain. Electronic address: jorge.diogene@irta.cat. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 62 EP - 68 VL - 102 KW - Marine Toxins KW - 0 KW - Ciguatoxins KW - 11050-21-8 KW - Index Medicus KW - Lionfish KW - Guadeloupe KW - Pterois spp. KW - Caribbean KW - Ciguatoxin KW - Ciguatera KW - Guadeloupe -- epidemiology KW - Animals KW - Caribbean Region -- epidemiology KW - Humans KW - Incidence KW - West Indies -- epidemiology KW - Prevalence KW - Marine Toxins -- analysis KW - Ciguatoxins -- toxicity KW - Ciguatera Poisoning -- epidemiology KW - Food Contamination -- analysis KW - Perciformes KW - Ciguatoxins -- analysis KW - Marine Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1695757075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.atitle=Prevalence+of+ciguatoxins+in+lionfish+%28Pterois+spp.%29+from+Guadeloupe%2C+Saint+Martin%2C+and+Saint+Barth%C3%A9lmy+Islands+%28Caribbean%29.&rft.au=Soli%C3%B1o%2C+Luc%C3%ADa%3BWidgy%2C+Saha%3BPautonnier%2C+Anthony%3BTurquet%2C+Jean%3BLoeffler%2C+Christopher+R%3BFlores+Quintana%2C+Harold+A%3BDiog%C3%A8ne%2C+Jorge&rft.aulast=Soli%C3%B1o&rft.aufirst=Luc%C3%ADa&rft.date=2015-08-01&rft.volume=102&rft.issue=&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Toxicon+%3A+official+journal+of+the+International+Society+on+Toxinology&rft.issn=1879-3150&rft_id=info:doi/10.1016%2Fj.toxicon.2015.05.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-07 N1 - Date created - 2015-07-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxicon.2015.05.015 ER - TY - JOUR T1 - Candidate HLA genes for prediction of co-trimoxazole-induced severe cutaneous reactions. AN - 1695756816; 26086150 AB - Co-trimoxazole is a sulfonamide-containing antibiotic that is effective in the treatment of several infections and for prophylaxis of Pneumocystis jiroveci pneumonia. This drug has been reported as a common culprit drug for the Stevens-Johnson syndrome (SJS) and for toxic epidermal necrolysis (TEN). Human leukocyte antigens (HLAs) play a key role in the immunopathogenesis of severe cutaneous reactions induced by several drugs. This study investigated the association between the HLA class I and HLA-DRB1 polymorphisms and co-trimoxazole-induced SJS/TEN in a Thai population. Forty-three patients with co-trimoxazole-induced SJS/TEN and 91 co-trimoxazole-tolerant patients were enrolled in the study. HLA class I and HLA-DRB1 were genotyped using the reverse sequence-specific oligonucleotide probe method. The frequencies of three alleles of HLA, namely HLA-B*15:02, HLA-C*06:02, and HLA-C*08:01, were significantly higher in the co-trimoxazole-induced SJS/TEN group compared with controls. The risks for co-trimoxazole-induced SJS/TEN in patients with the HLA-B*15:02, HLA-C*06:02, or HLA-C*08:01 allele were about 3-11-fold higher when compared with those who did not carry one of these alleles. Individuals who carried the HLA-B*15:02-C*08:01 haplotype had a 14-fold higher risk for co-trimoxazole-induced SJS/TEN. Evidence of associations between co-trimoxazole-induced SJS/TEN and HLA alleles including HLA-B*15:02, HLA-C*06:02, and HLA-C*08:01 were found in the study population. These findings may suggest that apart from the HLA molecules, other molecules involved in the molecular pathogenesis of these severe cutaneous adverse drug reactions may play an important role in the susceptibility of individuals to SJS/TEN caused by co-trimoxazole. JF - Pharmacogenetics and genomics AU - Kongpan, Thachanan AU - Mahasirimongkol, Surakameth AU - Konyoung, Parinya AU - Kanjanawart, Sirimas AU - Chumworathayi, Pansu AU - Wichukchinda, Nuanjun AU - Kidkeukarun, Runglak AU - Preechakul, Suphanlinee AU - Khunarkornsiri, Usanee AU - Bamrungram, Warawut AU - Supharatwattanakun, Butsaban AU - Mootsikapun, Piroon AU - Kwangsukstid, Supanida AU - Denjanta, Sukanda AU - Vannaprasaht, Suda AU - Rungapiromnan, Watcharee AU - Suwankesawong, Wimon AU - Tassaneeyakul, Wongwiwat AU - Tassaneeyakul, Wichittra AD - aDepartment of Pharmacology bPharmacy Unit cDepartment of Medicine, Faculty of Medicine dFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen eMedical Genetics Center, Medical Life Science Institute, Department of Medical Sciences, Ministry of Public Health fHealth Product Vigilance Center, Food and Drug Administration, Ministry of Public Health, Nonthaburi gPharmacy Unit hDepartment of Medicine, Udon Thani Hospital, Udon Thani iBuddhachinaraj Hospital, Phitsanulok jLampang Hospital, Lampang kRayong Hospital, Rayong lSongkhla Hospital, Songkhla mChiangraiprachanukroh Hospital, Chiangrai, Thailand. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 402 EP - 411 VL - 25 IS - 8 KW - HLA Antigens KW - 0 KW - Trimethoprim, Sulfamethoxazole Drug Combination KW - 8064-90-2 KW - Index Medicus KW - Demography KW - Alleles KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - HLA Antigens -- genetics KW - Genetic Association Studies KW - Stevens-Johnson Syndrome -- genetics KW - Genetic Predisposition to Disease KW - Trimethoprim, Sulfamethoxazole Drug Combination -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1695756816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Candidate+HLA+genes+for+prediction+of+co-trimoxazole-induced+severe+cutaneous+reactions.&rft.au=Kongpan%2C+Thachanan%3BMahasirimongkol%2C+Surakameth%3BKonyoung%2C+Parinya%3BKanjanawart%2C+Sirimas%3BChumworathayi%2C+Pansu%3BWichukchinda%2C+Nuanjun%3BKidkeukarun%2C+Runglak%3BPreechakul%2C+Suphanlinee%3BKhunarkornsiri%2C+Usanee%3BBamrungram%2C+Warawut%3BSupharatwattanakun%2C+Butsaban%3BMootsikapun%2C+Piroon%3BKwangsukstid%2C+Supanida%3BDenjanta%2C+Sukanda%3BVannaprasaht%2C+Suda%3BRungapiromnan%2C+Watcharee%3BSuwankesawong%2C+Wimon%3BTassaneeyakul%2C+Wongwiwat%3BTassaneeyakul%2C+Wichittra&rft.aulast=Kongpan&rft.aufirst=Thachanan&rft.date=2015-08-01&rft.volume=25&rft.issue=8&rft.spage=402&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=1744-6880&rft_id=info:doi/10.1097%2FFPC.0000000000000153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-11 N1 - Date created - 2015-07-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1097/FPC.0000000000000153 ER - TY - JOUR T1 - Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles. AN - 1683357323; 25968464 AB - Sepsis is a life threatening disease that is associated with high mortality. Existing treatments have failed to improve survivability in septic patients. The purpose of this present study is to evaluate whether cerium oxide nanoparticles (CeO2NPs) can prevent lipopolysaccharide (LPS) induced severe sepsis mortality by preventing hepatic dysfunction in male Sprague Dawley rats. Administration of a single dose (0.5 mg/kg) of CeO2NPs intravenously to septic rats significantly improved survival rates and functioned to restore body temperature, respiratory rate and blood pressure towards baseline. Treatment-induced increases in animal survivability were associated with decreased hepatic damage along with reductions in serum cytokines/chemokines, and diminished inflammatory related signaling. Kupffer cells and macrophage cells exposed to CeO2NPs exhibited decreases in LPS-induced cytokine release (TNF-α, IL-1β, IL-6, HMGB1) which were associated with diminished cellular ROS, reduced levels of nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), and decreased nuclear factor-kappa light chain enhancer of activated B cells (NF-kB) transcriptional activity. The findings of this study indicate that CeO2NPs may be useful as a therapeutic agent for sepsis. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Biomaterials AU - Selvaraj, Vellaisamy AU - Nepal, Niraj AU - Rogers, Steven AU - Manne, Nandini D P K AU - Arvapalli, Ravikumar AU - Rice, Kevin M AU - Asano, Shinichi AU - Fankhanel, Erin AU - Ma, Jane J AU - Shokuhfar, Tolou AU - Maheshwari, Mani AU - Blough, Eric R AD - Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA. ; Health Effects Laboratory Division, NIOSH, Morgantown, WV, USA. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, USA. ; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA; Department of Pharmacology, Physiology and Toxicology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA; Department of Pharmaceutical Sciences and Research, School of Pharmacy, Marshall University, Huntington, WV, USA. Electronic address: blough@marshall.edu. Y1 - 2015/08// PY - 2015 DA - August 2015 SP - 160 EP - 171 VL - 59 KW - Lipopolysaccharides KW - 0 KW - NF-kappa B KW - Cerium KW - 30K4522N6T KW - ceric oxide KW - 619G5K328Y KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Sepsis KW - Macrophage KW - Cytokines KW - Lipopolysaccharide KW - Cerium oxide nanoparticles KW - Rats KW - Microscopy, Electron, Transmission KW - Animals KW - Microscopy, Electron, Scanning KW - Sepsis -- chemically induced KW - Metal Nanoparticles -- chemistry KW - Mitogen-Activated Protein Kinases -- metabolism KW - Cerium -- therapeutic use KW - Sepsis -- drug therapy KW - Lipopolysaccharides -- toxicity KW - Metal Nanoparticles -- therapeutic use KW - Signal Transduction KW - NF-kappa B -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683357323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Inhibition+of+MAP+kinase%2FNF-kB+mediated+signaling+and+attenuation+of+lipopolysaccharide+induced+severe+sepsis+by+cerium+oxide+nanoparticles.&rft.au=Selvaraj%2C+Vellaisamy%3BNepal%2C+Niraj%3BRogers%2C+Steven%3BManne%2C+Nandini+D+P+K%3BArvapalli%2C+Ravikumar%3BRice%2C+Kevin+M%3BAsano%2C+Shinichi%3BFankhanel%2C+Erin%3BMa%2C+Jane+J%3BShokuhfar%2C+Tolou%3BMaheshwari%2C+Mani%3BBlough%2C+Eric+R&rft.aulast=Selvaraj&rft.aufirst=Vellaisamy&rft.date=2015-08-01&rft.volume=59&rft.issue=&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=1878-5905&rft_id=info:doi/10.1016%2Fj.biomaterials.2015.04.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-26 N1 - Date created - 2015-05-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cytokine. 2005 Feb 21;29(4):169-75 [15652449] J Immunol. 2004 Dec 1;173(11):6973-80 [15557194] J Surg Res. 2005 Nov;129(1):114-21 [16243048] FASEB J. 2005 Nov;19(13):1822-35 [16260652] J Endocrinol. 2006 Mar;188(3):503-11 [16522730] World J Gastroenterol. 2006 Dec 14;12(46):7413-20 [17167827] Cardiovasc Res. 2007 Feb 1;73(3):549-59 [17207782] Biochem Pharmacol. 2007 Mar 15;73(6):793-804 [17182007] Circulation. 2007 Aug 14;116(7):793-802 [17698745] Biomaterials. 2007 Nov;28(31):4600-7 [17675227] Nanomedicine (Lond). 2007 Jun;2(3):325-32 [17716177] Mitochondrion. 2008 Jun;8(3):211-8 [18417427] Small. 2009 Dec;5(24):2848-56 [19802857] J Clin Invest. 2011 Jan;121(1):308-17 [21183794] Nanoscale. 2011 Apr;3(4):1411-20 [21369578] J Physiol. 2011 May 1;589(Pt 9):2129-38 [21224240] J Pharmacol Exp Ther. 2011 Jul;338(1):53-61 [21464334] Int J Nanomedicine. 2011;6:2327-35 [22072870] Eur J Nutr. 2011 Dec;50(8):673-80 [21373948] Liver Int. 2012 Jan;32(1):8-20 [21745276] Biochim Biophys Acta. 2012 May;1822(5):714-28 [22101076] Mol Med. 2012;18:455-65 [22252713] Chemosphere. 2013 Jan;90(3):1201-9 [23121984] Environ Toxicol. 2013 Feb;28(2):107-18 [21618676] PLoS One. 2013;8(8):e70832 [23967115] Biomaterials. 2014 Jan;35(1):249-58 [24140045] Exp Eye Res. 2013 Nov;116:63-74 [23978600] Toxicol Pathol. 2014 Aug;42(6):984-96 [24178579] Lancet. 2005 Jan 1-7;365(9453):63-78 [15639681] J R Coll Surg Edinb. 2000 Jun;45(3):178-82 [10881485] Crit Care Med. 2001 Jul;29(7):1303-10 [11445675] Inflammation. 2002 Jun;26(3):129-37 [12083419] Chest. 1992 Jun;101(6):1644-55 [1303622] Eur J Pharmacol. 1995 Mar 16;292(3-4):341-4 [7796876] Cancer Res. 1998 Feb 15;58(4):717-23 [9485026] Biochemistry (Mosc). 1998 Jul;63(7):826-32 [9721335] Fish Shellfish Immunol. 2005 Oct;19(4):293-306 [15863011] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.biomaterials.2015.04.025 ER - TY - RPRT T1 - NATIONAL INSTITUTES OF HEALTH BETHESDA CHILLED WATER SYSTEM IMPROVEMENTS, MONTGOMERY COUNTY, BETHESDA, MARYLAND. AN - 16382572; 16580 AB - PURPOSE: The National Institutes of Health (NIH) is contemplating implementation of chilled water system improvements at the NIH Bethesda Campus. The need for the chilled water system improvements is to prevent a disruption in the chilled water supply which would result in severe consequences on patient care, animal welfare, and biomedical research. Improvements are needed to address real deficiencies within the campus water systems. Three alternatives were considered in detail in the Draft Environmental Impact Statement. The Proposed Action would install a Thermal Energy Storage System and an Industrial Water Storage System to provide sufficient storage capacity to meet two days of chilled water demand and two days of industrial water demand should an outside disturbance interrupt the water supply. The Alternative Action would install a Thermal Energy Storage System and a Potable Water Storage System to provide sufficient storage capacity to meet two days of chilled water demand and two days of potable water demand. The No-Action Alternative would continue current NIH operations and would not implement chilled water system improvements. The NIH's preferred alternative is the Proposed Action alternative. JF - EPA number: 150203, Final EIS, July 31, 2015 Y1 - 2015/07/31/ PY - 2015 DA - 2015 Jul 31 KW - Water KW - Water Storage KW - Water Supply KW - Industrial Water KW - Water Resources KW - Wetlands KW - Floodplains KW - Traffic Analyses KW - Noise KW - Air Quality KW - Vegetation KW - Archaeological Sites KW - Socioeconomic Assessments KW - Emissions KW - Historic Sites KW - Waste Management KW - Maryland KW - Clean Air Act Amendments of 1990, Emission Standards KW - Resources Conservation and Recovery Act, Compliance KW - National Historic Preservation Act of 1966, Historic Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16382572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2015-07-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CHILLED+WATER+SYSTEM+IMPROVEMENTS%2C+MONTGOMERY+COUNTY%2C+BETHESDA%2C+MARYLAND.&rft.title=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CHILLED+WATER+SYSTEM+IMPROVEMENTS%2C+MONTGOMERY+COUNTY%2C+BETHESDA%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland N1 - Date revised - 2017-02-01 N1 - SuppNotes - Final. Preparation date: July 31, 2015 N1 - Last updated - 2017-02-06 ER - TY - JOUR T1 - Incidence of solid tumours among pesticide applicators exposed to the organophosphate insecticide diazinon in the Agricultural Health Study: an updated analysis AN - 1808632960; PQ0003435541 AB - ObjectiveDiazinon, a common organophosphate insecticide with genotoxic properties, was previously associated with lung cancer in the Agricultural Health Study (AHS) cohort, but few other epidemiological studies have examined diazinon-associated cancer risk. We used updated diazinon exposure and cancer incidence information to evaluate solid tumour risk in the AHS.MethodsMale pesticide applicators in Iowa and North Carolina reported lifetime diazinon use at enrolment (1993-1997) and follow-up (1998-2005); cancer incidence was assessed through 2010(North Carolina)/2011(Iowa). Among applicators with usage information sufficient to evaluate exposure-response patterns, we used Poisson regression to estimate adjusted rate ratios (RRs) and 95% CI for cancer sites with greater than or equal to 10 exposed cases for both lifetime (LT) exposure days and intensity-weighted (IW) lifetime exposure days (accounting for factors impacting exposure).ResultsWe observed elevated lung cancer risks (N=283) among applicators with the greatest number of LT (RR=1.60; 95% CI 1.11 to 2.31; Ptrend=0.02) and IW days of diazinon use (RR=1.41; 95% CI 0.98 to 2.04; Ptrend=0.08). Kidney cancer (N=94) risks were non-significantly elevated (RRLT days=1.77; 95% CI 0.90 to 3.51; Ptrend=0.09; RRIW days 1.37; 95% CI 0.64 to 2.92; Ptrend=0.50), as were risks for aggressive prostate cancer (N=656).ConclusionsOur updated evaluation of diazinon provides additional evidence of an association with lung cancer risk. Newly identified links to kidney cancer and associations with aggressive prostate cancer require further evaluation. JF - Occupational and Environmental Medicine AU - Jones, Rena R AU - Barone-Adesi, Francesco AU - Koutros, Stella AU - Lerro, Catherine C AU - Blair, Aaron AU - Lubin, Jay AU - Heltshe, Sonya L AU - Hoppin, Jane A AU - Alavanja, Michael C R AU - Beane Freeman, Laura E AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2015/07/23/ PY - 2015 DA - 2015 Jul 23 SP - 496 EP - 503 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 72 IS - 7 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts KW - diazinon KW - insecticides KW - organophosphate KW - neoplasms KW - Risk assessment KW - ANW, USA, North Carolina KW - Organophosphates KW - Genotoxicity KW - Cancer KW - Health risks KW - Insecticides KW - Prostate cancer KW - USA, Iowa KW - Dose-response effects KW - Risk factors KW - Pesticides KW - Kidney KW - Diazinon KW - Lung cancer KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808632960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Incidence+of+solid+tumours+among+pesticide+applicators+exposed+to+the+organophosphate+insecticide+diazinon+in+the+Agricultural+Health+Study%3A+an+updated+analysis&rft.au=Jones%2C+Rena+R%3BBarone-Adesi%2C+Francesco%3BKoutros%2C+Stella%3BLerro%2C+Catherine+C%3BBlair%2C+Aaron%3BLubin%2C+Jay%3BHeltshe%2C+Sonya+L%3BHoppin%2C+Jane+A%3BAlavanja%2C+Michael+C+R%3BBeane+Freeman%2C+Laura+E&rft.aulast=Jones&rft.aufirst=Rena&rft.date=2015-07-23&rft.volume=72&rft.issue=7&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102728 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Organophosphates; Genotoxicity; Cancer; Health risks; Prostate cancer; Insecticides; Risk factors; Dose-response effects; Pesticides; Kidney; Diazinon; Lung cancer; ANW, USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1136/oemed-2014-102728 ER - TY - JOUR T1 - Performance of genetic risk factors in prediction of trichloroethylene induced hypersensitivity syndrome. AN - 1698962336; 26190474 AB - Trichloroethylene induced hypersensitivity syndrome is dose-independent and potentially life threatening disease, which has become one of the serious occupational health issues and requires intensive treatment. To discover the genetic risk factors and evaluate the performance of risk prediction model for the disease, we conducted genomewide association study and replication study with total of 174 cases and 1761 trichloroethylene-tolerant controls. Fifty seven SNPs that exceeded the threshold for genome-wide significance (P < 5 × 10(-8)) were screened to relate with the disease, among which two independent SNPs were identified, that is rs2857281 at MICA (odds ratio, 11.92; P meta = 1.33 × 10(-37)) and rs2523557 between HLA-B and MICA (odds ratio, 7.33; P meta = 8.79 × 10(-35)). The genetic risk score with these two SNPs explains at least 20.9% of the disease variance and up to 32.5-fold variation in inter-individual risk. Combining of two SNPs as predictors for the disease would have accuracy of 80.73%, the area under receiver operator characteristic curves (AUC) scores was 0.82 with sensitivity of 74% and specificity of 85%, which was considered to have excellent discrimination for the disease, and could be considered for translational application for screening employees before exposure. JF - Scientific reports AU - Dai, Yufei AU - Chen, Ying AU - Huang, Hanlin AU - Zhou, Wei AU - Niu, Yong AU - Zhang, Mingrong AU - Bin, Ping AU - Dong, Haiyan AU - Jia, Qiang AU - Huang, Jianxun AU - Yi, Juan AU - Liao, Qijun AU - Li, Haishan AU - Teng, Yanxia AU - Zang, Dan AU - Zhai, Qingfeng AU - Duan, Huawei AU - Shen, Juan AU - He, Jiaxi AU - Meng, Tao AU - Sha, Yan AU - Shen, Meili AU - Ye, Meng AU - Jia, Xiaowei AU - Xiang, Yingping AU - Huang, Huiping AU - Wu, Qifeng AU - Shi, Mingming AU - Huang, Xianqing AU - Yang, Huanming AU - Luo, Longhai AU - Li, Sai AU - Li, Lin AU - Zhao, Jinyang AU - Li, Laiyu AU - Wang, Jun AU - Zheng, Yuxin AD - Key laboratory of Chemical Safety and Health, Chinese Centre for Disease Control and Prevention. National Institute for Occupational Health and Poison Control, Chinese Centre for Disease Control and Prevention, Beijing, 100050, China. ; BGI-Tech, BGI-Shenzhen, Shenzhen, China. ; Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou, China. ; Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, China. ; Center for Disease Control and Prevention of Yunnan province, Kunming, Yunnan, China. ; Shandong Academy of Occupational Health and Occupational Medicine, Jinan, China. ; Institute of chemicals safety, Chinese academy of inspection and quarantine, Beijing, China. ; Health Supervision Institutionof Dongcheng Health Bureau, Beijing, China. ; Food And Drug Administration Of Beijing Fengtai District, Beijing, China. ; Weifang Medical University, Weifang, Shandong, China. Y1 - 2015/07/20/ PY - 2015 DA - 2015 Jul 20 SP - 12169 VL - 5 KW - Anesthetics, Inhalation KW - 0 KW - Histocompatibility Antigens KW - Trichloroethylene KW - 290YE8AR51 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - ROC Curve KW - Risk Factors KW - Humans KW - Prognosis KW - Case-Control Studies KW - Histocompatibility Antigens -- genetics KW - Genome-Wide Association Study KW - Anesthetics, Inhalation -- adverse effects KW - Drug Hypersensitivity Syndrome -- etiology KW - Trichloroethylene -- adverse effects KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698962336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Performance+of+genetic+risk+factors+in+prediction+of+trichloroethylene+induced+hypersensitivity+syndrome.&rft.au=Dai%2C+Yufei%3BChen%2C+Ying%3BHuang%2C+Hanlin%3BZhou%2C+Wei%3BNiu%2C+Yong%3BZhang%2C+Mingrong%3BBin%2C+Ping%3BDong%2C+Haiyan%3BJia%2C+Qiang%3BHuang%2C+Jianxun%3BYi%2C+Juan%3BLiao%2C+Qijun%3BLi%2C+Haishan%3BTeng%2C+Yanxia%3BZang%2C+Dan%3BZhai%2C+Qingfeng%3BDuan%2C+Huawei%3BShen%2C+Juan%3BHe%2C+Jiaxi%3BMeng%2C+Tao%3BSha%2C+Yan%3BShen%2C+Meili%3BYe%2C+Meng%3BJia%2C+Xiaowei%3BXiang%2C+Yingping%3BHuang%2C+Huiping%3BWu%2C+Qifeng%3BShi%2C+Mingming%3BHuang%2C+Xianqing%3BYang%2C+Huanming%3BLuo%2C+Longhai%3BLi%2C+Sai%3BLi%2C+Lin%3BZhao%2C+Jinyang%3BLi%2C+Laiyu%3BWang%2C+Jun%3BZheng%2C+Yuxin&rft.aulast=Dai&rft.aufirst=Yufei&rft.date=2015-07-20&rft.volume=5&rft.issue=&rft.spage=12169&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep12169 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-03 N1 - Date created - 2015-07-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Transplant. 2009 Feb;9(2):251-7 [19178412] Crit Rev Toxicol. 2000 May;30(3):253-85 [10852497] Environ Health Perspect. 2009 May;117(5):696-702 [19479009] Exp Clin Immunogenet. 2000;17(3):130-7 [10899738] Tissue Antigens. 2000 Dec;56(6):548-50 [11169245] Nat Immunol. 2001 Mar;2(3):255-60 [11224526] J Occup Health. 2003 Jan;45(1):8-14 [14605423] Radiology. 1982 Apr;143(1):29-36 [7063747] Science. 1988 Jun 3;240(4857):1285-93 [3287615] Crit Rev Toxicol. 1989;20(1):31-50 [2673291] Arthritis Rheum. 1998 Jan;41(1):68-73 [9433871] Invest Ophthalmol Vis Sci. 1999 Aug;40(9):1921-6 [10440244] Biomarkers. 2004 Nov-Dec;9(6):470-8 [15849067] Occup Environ Med. 2005 Sep;62(9):657-62, 597 [16109824] J Occup Health. 2006 Nov;48(6):417-23 [17179634] Toxicol Sci. 2007 Feb;95(2):401-11 [17077186] Int Arch Occup Environ Health. 2007 Apr;80(5):357-70 [17106739] Am J Hum Genet. 2007 Sep;81(3):559-75 [17701901] Environ Health Perspect. 2007 Nov;115(11):1553-6 [18007983] Trends Immunol. 2008 Aug;29(8):397-403 [18602338] J Occup Health. 2008;50(4):328-38 [18540116] PLoS Genet. 2009 Oct;5(10):e1000678 [19816555] Ind Health. 2009 Oct;47(5):479-86 [19834256] Tissue Antigens. 2010 Jan;75(1):48-55 [19895570] Nat Rev Genet. 2010 Jun;11(6):446-50 [20479774] Dermatology. 2010 Aug;221(1):17-22 [20407216] J Dermatol. 2011 Mar;38(3):229-35 [21342224] Endocr J. 2011;58(9):723-39 [21778616] Arthritis Res Ther. 2011;13(1):101 [21345260] Nature. 2012 Nov 1;491(7422):56-65 [23128226] Lancet Oncol. 2012 Dec;13(12):1192-3 [23323277] Allergol Int. 2013 Mar;62(1):21-8 [23439055] Nat Rev Genet. 2013 Jul;14(7):507-15 [23774735] J Dermatol Sci. 2013 Dec;72(3):218-24 [23928230] Eur J Hum Genet. 2014 Mar;22(3):402-8 [23881057] Brief Funct Genomics. 2014 Sep;13(5):384-91 [24771349] Curr Diab Rep. 2009 Apr;9(2):157-63 [19323961] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep12169 ER - TY - JOUR T1 - Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases. AN - 1696681187; 26168713 AB - With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism that circumvents existing resistance. ETX0914, the first of a new class of antibacterial agent targeted for the treatment of gonorrhea, operates by a novel mode-of-inhibition against bacterial type II topoisomerases. Incorporating an oxazolidinone on the scaffold mitigated toxicological issues often seen with topoisomerase inhibitors. Organisms resistant to other topoisomerase inhibitors were not cross-resistant with ETX0914 nor were spontaneous resistant mutants to ETX0914 cross-resistant with other topoisomerase inhibitor classes, including the widely used fluoroquinolone class. Preclinical evaluation of ETX0914 pharmacokinetics and pharmacodynamics showed distribution into vascular tissues and efficacy in a murine Staphylococcus aureus infection model that served as a surrogate for predicting efficacious exposures for the treatment of Neisseria gonorrhoeae infections. A wide safety margin to the efficacious exposure in toxicological evaluations supported progression to Phase 1. Dosing ETX0914 in human volunteers showed sufficient exposure and minimal adverse effects to expect a highly efficacious anti-gonorrhea therapy. JF - Scientific reports AU - Basarab, Gregory S AU - Kern, Gunther H AU - McNulty, John AU - Mueller, John P AU - Lawrence, Kenneth AU - Vishwanathan, Karthick AU - Alm, Richard A AU - Barvian, Kevin AU - Doig, Peter AU - Galullo, Vincent AU - Gardner, Humphrey AU - Gowravaram, Madhusudhan AU - Huband, Michael AU - Kimzey, Amy AU - Morningstar, Marshall AU - Kutschke, Amy AU - Lahiri, Sushmita D AU - Perros, Manos AU - Singh, Renu AU - Schuck, Virna J A AU - Tommasi, Ruben AU - Walkup, Grant AU - Newman, Joseph V AD - Department of Chemistry, Drug Discovery and Development Center, University of Cape Town, Rondebosch 7701, South Africa. ; AstraZeneca R&D Boston, Infection iMed, 35 Gatehouse Dr. Waltham, MA 02415 USA. ; Shire Pharmaceuticals, 300 Shire Way, Lexington, MA 02421. ; Entasis Therapeutics, 35 Gatehouse Drive Suite E0, Waltham, MA 02415 USA. ; Albany Molecular Research Inc., 26 Corporate Circle, Albany, NY 12203. ; Center for Drug Evaluation and Research, U.S. FDA, 10903 New Hampshire Avenue, Silver Spring, MD 20993. ; JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North Liberty, IA 52317. ; Broad Institute, 415 Main St., Cambridge, MA 02142. ; Norvartis Pharmaceutical Corporation, Bldg. 335, Office 3104B, One Health Plaza, East Hanover, NJ 07936-1080. Y1 - 2015/07/14/ PY - 2015 DA - 2015 Jul 14 SP - 11827 VL - 5 KW - AZD0914 KW - 0 KW - Anti-Bacterial Agents KW - Barbiturates KW - Fluoroquinolones KW - Spiro Compounds KW - Topoisomerase II Inhibitors KW - DNA Topoisomerases, Type II KW - EC 5.99.1.3 KW - Index Medicus KW - Young Adult KW - Animals KW - Drug Resistance, Bacterial KW - Humans KW - Disease Models, Animal KW - Rats KW - Staphylococcal Infections -- drug therapy KW - Adult KW - Neisseria gonorrhoeae -- genetics KW - Microbial Sensitivity Tests KW - Male KW - DNA Topoisomerases, Type II -- chemistry KW - Dose-Response Relationship, Drug KW - Models, Molecular KW - Mice KW - Staphylococcal Infections -- microbiology KW - Staphylococcus aureus -- drug effects KW - Haplorhini KW - Neisseria gonorrhoeae -- drug effects KW - Dogs KW - Fluoroquinolones -- pharmacology KW - Middle Aged KW - Molecular Conformation KW - Mutation KW - Female KW - Anti-Bacterial Agents -- therapeutic use KW - Spiro Compounds -- chemistry KW - Barbiturates -- pharmacology KW - Barbiturates -- therapeutic use KW - Anti-Bacterial Agents -- pharmacology KW - Gonorrhea -- microbiology KW - Topoisomerase II Inhibitors -- chemistry KW - Topoisomerase II Inhibitors -- pharmacology KW - Barbiturates -- chemistry KW - Spiro Compounds -- pharmacology KW - Topoisomerase II Inhibitors -- therapeutic use KW - Anti-Bacterial Agents -- chemistry KW - Gonorrhea -- drug therapy KW - Spiro Compounds -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1696681187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Responding+to+the+challenge+of+untreatable+gonorrhea%3A+ETX0914%2C+a+first-in-class+agent+with+a+distinct+mechanism-of-action+against+bacterial+Type+II+topoisomerases.&rft.au=Basarab%2C+Gregory+S%3BKern%2C+Gunther+H%3BMcNulty%2C+John%3BMueller%2C+John+P%3BLawrence%2C+Kenneth%3BVishwanathan%2C+Karthick%3BAlm%2C+Richard+A%3BBarvian%2C+Kevin%3BDoig%2C+Peter%3BGalullo%2C+Vincent%3BGardner%2C+Humphrey%3BGowravaram%2C+Madhusudhan%3BHuband%2C+Michael%3BKimzey%2C+Amy%3BMorningstar%2C+Marshall%3BKutschke%2C+Amy%3BLahiri%2C+Sushmita+D%3BPerros%2C+Manos%3BSingh%2C+Renu%3BSchuck%2C+Virna+J+A%3BTommasi%2C+Ruben%3BWalkup%2C+Grant%3BNewman%2C+Joseph+V&rft.aulast=Basarab&rft.aufirst=Gregory&rft.date=2015-07-14&rft.volume=5&rft.issue=&rft.spage=11827&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep11827 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-10 N1 - Date created - 2015-07-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2004 Oct;32(10):1092-5 [15217988] Antimicrob Agents Chemother. 2002 Jun;46(6):1665-70 [12019073] Sex Transm Infect. 2013 Dec;89 Suppl 4:iv5-10 [24243881] Clin Infect Dis. 2014 Jan;58 Suppl 1:S20-7 [24343828] J Med Chem. 2013 Nov 14;56(21):8712-35 [24098982] Chem Rev. 2014 Feb 26;114(4):2313-42 [24313284] Biochemistry. 2014 Mar 18;53(10):1565-74 [24576155] Expert Rev Anti Infect Ther. 2014 Jun;12(6):653-6 [24702589] J Clin Microbiol. 2014 Jul;52(7):2629-32 [24759716] Antimicrob Agents Chemother. 2002 Nov;46(11):3484-9 [12384354] Drugs. 2003;63(24):2769-802 [14664657] Clin Pharmacokinet. 2003;42(15):1411-23 [14674791] Pacing Clin Electrophysiol. 2003 Dec;26(12):2317-20 [14675020] Expert Opin Drug Saf. 2004 Sep;3(5):405-14 [15335296] J Antimicrob Chemother. 2014 Aug;69(8):2086-90 [24777907] Clin Pharmacol Ther. 2014 Aug;96(2):151-3 [25056396] Antimicrob Agents Chemother. 1987 Jul;31(7):1054-60 [3116917] Xenobiotica. 1987 Oct;17(10):1139-45 [3424863] J Infect Dis. 1989 Feb;159(2):281-92 [2644371] Antimicrob Agents Chemother. 1991 Aug;35(8):1647-50 [1656869] Antimicrob Agents Chemother. 1993 May;37(5):1073-81 [8517694] Antimicrob Agents Chemother. 1993 Sep;37(9):2007-8 [8239622] Diagn Microbiol Infect Dis. 1995 May-Jun;22(1-2):89-96 [7587056] Clin Infect Dis. 1998 Jan;26(1):1-10; quiz 11-2 [9455502] Clin Microbiol Infect. 2005 Apr;11(4):256-80 [15760423] Med Clin North Am. 2006 Nov;90(6):1165-82 [17116442] Int J Antimicrob Agents. 2007 Apr;29(4):374-9 [17241772] J Infect Dis. 2007 Jun 15;195(12):1818-27 [17492598] Antimicrob Agents Chemother. 2008 Aug;52(8):2806-12 [18519725] Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49 [18625781] Nucleic Acids Res. 2008 Oct;36(17):5516-29 [18723572] J Am Chem Soc. 2009 Mar 25;131(11):3991-7 [19260642] J Med Microbiol. 2009 May;58(Pt 5):683-7 [19369534] N Engl J Med. 2009 Jun 4;360(23):2397-405 [19494215] Antimicrob Agents Chemother. 2009 Aug;53(8):3331-6 [19433553] Intern Med J. 2009 Sep;39(9):619-23 [19769684] J Med Chem. 2009 Nov 12;52(21):6752-6 [19827778] Ann N Y Acad Sci. 2011 Aug;1230:E19-28 [22239555] N Engl J Med. 2012 Feb 9;366(6):485-7 [22316442] J Med Chem. 2012 Aug 9;55(15):6916-33 [22779424] Biochem Pharmacol. 2012 Oct 1;84(7):900-4 [22820247] Nucleic Acids Res. 2013 Apr;41(8):4628-39 [23460203] Curr Drug Saf. 2014;9(2):89-105 [24410307] J Med Chem. 2014 Nov 13;57(21):9078-95 [25286019] Org Lett. 2014 Dec 19;16(24):6456-9 [25458849] ACS Chem Biol. 2014 Dec 19;9(12):2895-904 [25310082] Antimicrob Agents Chemother. 2015 Jan;59(1):467-74 [25385112] Antimicrob Agents Chemother. 2015 Mar;59(3):1478-86 [25534723] Antimicrob Agents Chemother. 2014 Sep;58(9):5585-8 [24982070] Drugs. 2000 Jan;59(1):7-16 [10718097] Antimicrob Agents Chemother. 2001 Oct;45(10):2755-64 [11557465] J Antimicrob Chemother. 2001 Oct;48(4):545-8 [11581235] Annu Rev Biochem. 2001;70:369-413 [11395412] Clin Infect Dis. 2002 Mar 1;34(5):695-8 [11803505] Erratum In: Sci Rep. 2015;5:14157 [26383116] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep11827 ER - TY - JOUR T1 - Effects of nitrogen-doped multi-walled carbon nanotubes compared to pristine multi-walled carbon nanotubes on human small airway epithelial cells. AN - 1688000050; 25797581 AB - Nitrogen-doped multi-walled carbon nanotubes (ND-MWCNTs) are modified multi-walled carbon nanotubes (MWCNTs) with enhanced electrical properties that are used in a variety of applications, including fuel cells and sensors; however, the mode of toxic action of ND-MWCNT has yet to be fully elucidated. In the present study, we compared the interaction of ND-MWCNT or pristine MWCNT-7 with human small airway epithelial cells (SAEC) and evaluated their subsequent bioactive effects. Transmission electron microscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, and X-ray diffraction suggested the presence of N-containing defects in the lattice of the nanotube. The ND-MWCNTs were determined to be 93.3% carbon, 3.8% oxygen, and 2.9% nitrogen. A dose-response cell proliferation assay showed that low doses of ND-MWCNT (1.2μg/ml) or MWCNT-7 (0.12μg/ml) increased cellular proliferation, while the highest dose of 120μg/ml of either material decreased proliferation. ND-MWCNT and MWCNT-7 appeared to interact with SAEC at 6h and were internalized by 24h. ROS were elevated at 6 and 24h in ND-MWCNT exposed cells, but only at 6h in MWCNT-7 exposed cells. Significant alterations to the cell cycle were observed in SAEC exposed to either 1.2μg/ml of ND-MWCNT or MWCNT-7 in a time and material-dependent manner, possibly suggesting potential damage or alterations to cell cycle machinery. Our results indicate that ND-MWCNT induce effects in SAEC over a time and dose-related manner which differ from MWCNT-7. Therefore, the physicochemical characteristics of the materials appear to alter their biological effects. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Mihalchik, Amy L AU - Ding, Weiqiang AU - Porter, Dale W AU - McLoughlin, Colleen AU - Schwegler-Berry, Diane AU - Sisler, Jennifer D AU - Stefaniak, Aleksandr B AU - Snyder-Talkington, Brandi N AU - Cruz-Silva, Rodolfo AU - Terrones, Mauricio AU - Tsuruoka, Shuji AU - Endo, Morinobu AU - Castranova, Vincent AU - Qian, Yong AD - Pharmaceutical and Pharmacological Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, United States; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States. ; Shared Research Facilities, West Virginia University, Morgantown, WV 26505, United States. ; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States. ; Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States. ; Research Center for Exotic Nanocarbons, Shinshu University, Nagano, Japan. ; Research Center for Exotic Nanocarbons, Shinshu University, Nagano, Japan; Departments of Physics, Chemistry, Materials Science & Engineering, and Center for 2-Dimensional and Layered Materials, The Pennsylvania State University, University Park, PA 16802, United States. ; Pharmaceutical and Pharmacological Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, United States. ; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States. Electronic address: yaq2@cdc.gov. Y1 - 2015/07/03/ PY - 2015 DA - 2015 Jul 03 SP - 25 EP - 36 VL - 333 KW - Nanotubes, Carbon KW - 0 KW - Reactive Oxygen Species KW - Phosphothreonine KW - 1114-81-4 KW - Phosphotyrosine KW - 21820-51-9 KW - CDK4 protein, human KW - EC 2.7.11.22 KW - Cyclin-Dependent Kinase 4 KW - Nitrogen KW - N762921K75 KW - Index Medicus KW - Reactive oxygen species KW - Functionalized multi-walled carbon nanotubes KW - Multi-walled carbon nanotubes KW - Cell Proliferation -- drug effects KW - Reactive Oxygen Species -- metabolism KW - X-Ray Diffraction KW - Dose-Response Relationship, Drug KW - Humans KW - Phosphotyrosine -- metabolism KW - Spectrum Analysis, Raman KW - Risk Assessment KW - Phosphothreonine -- metabolism KW - Cyclin-Dependent Kinase 4 -- metabolism KW - Microscopy, Electron, Transmission KW - Photoelectron Spectroscopy KW - Cell Survival -- drug effects KW - Cells, Cultured KW - Toxicity Tests -- methods KW - Time Factors KW - Cell Cycle -- drug effects KW - Microscopy, Electron, Scanning KW - Epithelial Cells -- ultrastructure KW - Epithelial Cells -- metabolism KW - Bronchioles -- metabolism KW - Bronchioles -- drug effects KW - Epithelial Cells -- drug effects KW - Nitrogen -- toxicity KW - Nitrogen -- metabolism KW - Nanotubes, Carbon -- toxicity KW - Bronchioles -- ultrastructure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1688000050?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Effects+of+nitrogen-doped+multi-walled+carbon+nanotubes+compared+to+pristine+multi-walled+carbon+nanotubes+on+human+small+airway+epithelial+cells.&rft.au=Mihalchik%2C+Amy+L%3BDing%2C+Weiqiang%3BPorter%2C+Dale+W%3BMcLoughlin%2C+Colleen%3BSchwegler-Berry%2C+Diane%3BSisler%2C+Jennifer+D%3BStefaniak%2C+Aleksandr+B%3BSnyder-Talkington%2C+Brandi+N%3BCruz-Silva%2C+Rodolfo%3BTerrones%2C+Mauricio%3BTsuruoka%2C+Shuji%3BEndo%2C+Morinobu%3BCastranova%2C+Vincent%3BQian%2C+Yong&rft.aulast=Mihalchik&rft.aufirst=Amy&rft.date=2015-07-03&rft.volume=333&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-17 N1 - Date created - 2015-06-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Carcinogenesis. 2005 Apr;26(4):725-31 [15677631] Nano Lett. 2005 Dec;5(12):2448-64 [16351195] Science. 2006 Feb 3;311(5761):622-7 [16456071] Nano Lett. 2006 Aug;6(8):1609-16 [16895344] Small. 2007 Oct;3(10):1723-9 [17849378] Inhal Toxicol. 2008 Jun;20(8):741-9 [18569096] Nat Nanotechnol. 2008 Jul;3(7):423-8 [18654567] Biochem Biophys Res Commun. 2009 Feb 6;379(2):643-8 [19121628] Biosens Bioelectron. 2009 Oct 15;25(2):373-7 [19683424] Toxicology. 2010 Mar 10;269(2-3):136-47 [19857541] J Toxicol Environ Health A. 2010;73(12):819-36 [20391123] Part Fibre Toxicol. 2010;7:28 [20920331] Toxicol Appl Pharmacol. 2010 Nov 15;249(1):8-15 [20800606] Toxicol Appl Pharmacol. 2011 Aug 15;255(1):18-31 [21624382] Part Fibre Toxicol. 2011;8:21 [21781304] Biomaterials. 2011 Oct;32(30):7677-86 [21764122] J Toxicol Environ Health A. 2012;75(2):112-28 [22129238] Chem Res Toxicol. 2011 Dec 19;24(12):2237-48 [22081859] Cell Signal. 2012 May;24(5):981-90 [22286106] Toxicol In Vitro. 2012 Aug;26(5):672-7 [22449549] Chem Res Toxicol. 2012 Jun 18;25(6):1212-21 [22428663] Gene. 2012 Dec 10;511(1):1-6 [22981713] J Toxicol Environ Health B Crit Rev. 2012;15(7):468-92 [23190270] ACS Nano. 2013 Mar 26;7(3):2352-68 [23414138] Toxicol Sci. 2013 May;133(1):79-89 [23377615] Curr Opin Biotechnol. 2013 Aug;24(4):724-34 [23768801] Part Fibre Toxicol. 2013;10:35 [23903001] Toxicol Appl Pharmacol. 2013 Oct 15;272(2):476-89 [23845593] Nanotoxicology. 2013 Nov;7(7):1179-94 [22881873] Part Fibre Toxicol. 2013;10:44 [24004820] Nanotoxicology. 2014 Aug;8(5):485-507 [23634900] Part Fibre Toxicol. 2014;11:6 [24479647] Bioorg Khim. 2013 Jul-Aug;39(4):383-99 [24707719] Biomaterials. 2014 Aug;35(24):6657-66 [24818879] Part Fibre Toxicol. 2013;10:33 [23895460] Free Radic Biol Med. 2014 Aug;73:84-94 [24824983] Nanotoxicology. 2015 May;9(4):413-22 [25030099] J Cell Sci. 2004 Mar 15;117(Pt 8):1281-3 [15020666] Gene. 2004 Aug 4;337:1-13 [15276197] Cell. 1995 Jan 27;80(2):179-85 [7834738] Cell. 1995 Jan 27;80(2):225-36 [7834742] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.03.008 ER - TY - JOUR T1 - Sodium nitrite potentiates renal oxidative stress and injury in hemoglobin exposed guinea pigs. AN - 1687999756; 25891524 AB - Methemoglobin-forming drugs, such as sodium nitrite (NaNO2), may exacerbate oxidative toxicity under certain chronic or acute hemolytic settings. In this study, we evaluated markers of renal oxidative stress and injury in guinea pigs exposed to extracellular hemoglobin (Hb) followed by NaNO2 at doses sufficient to simulate clinically relevant acute methemoglobinemia. NaNO2 induced rapid and extensive oxidation of plasma Hb in this model. This was accompanied by increased renal expression of the oxidative response effectors nuclear factor erythroid 2-derived-factor 2 (Nrf-2) and heme oxygenase-1 (HO-1), elevated non-heme iron deposition, lipid peroxidation, interstitial inflammatory cell activation, increased expression of tubular injury markers kidney injury-1 marker (KIM-1) and liver-fatty acid binding protein (L-FABP), podocyte injury, and cell death. Importantly, these indicators of renal oxidative stress and injury were minimal or absent following infusion of Hb or NaNO2 alone. Together, these results suggest that the exposure to NaNO2 in settings associated with increased extracellular Hb may potentiate acute renal toxicity via processes that are independent of NaNO2 induced erythrocyte methemoglobinemia. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Baek, Jin Hyen AU - Zhang, Xiaoyuan AU - Williams, Matthew C AU - Hicks, Wayne AU - Buehler, Paul W AU - D'Agnillo, Felice AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA. ; Laboratory of Biochemistry and Vascular Biology, Division of Hematology Research and Review, Center for Biologics Evaluation and Research (CBER), U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA. Electronic address: felice.dagnillo@fda.hhs.gov. Y1 - 2015/07/03/ PY - 2015 DA - 2015 Jul 03 SP - 89 EP - 99 VL - 333 KW - Biomarkers KW - 0 KW - Fatty Acid-Binding Proteins KW - Hemoglobins KW - NF-E2-Related Factor 2 KW - Nitrates KW - sodium nitrate KW - 8M4L3H2ZVZ KW - Methemoglobin KW - 9008-37-1 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Index Medicus KW - Hemoglobin KW - Heme KW - Oxidative stress KW - Kidney KW - Nitrite KW - Animals KW - Infusions, Intravenous KW - Dose-Response Relationship, Drug KW - Guinea Pigs KW - Lipid Peroxidation -- drug effects KW - Cell Death -- drug effects KW - NF-E2-Related Factor 2 -- metabolism KW - Fatty Acid-Binding Proteins -- metabolism KW - Oxidation-Reduction KW - Heme Oxygenase-1 -- metabolism KW - Methemoglobin -- metabolism KW - Biomarkers -- metabolism KW - Drug Synergism KW - Time Factors KW - Male KW - Kidney -- metabolism KW - Kidney -- pathology KW - Kidney -- drug effects KW - Hemoglobins -- administration & dosage KW - Methemoglobinemia -- pathology KW - Acute Kidney Injury -- blood KW - Nitrates -- administration & dosage KW - Acute Kidney Injury -- pathology KW - Hemoglobins -- toxicity KW - Nitrates -- toxicity KW - Acute Kidney Injury -- chemically induced KW - Oxidative Stress -- drug effects KW - Methemoglobinemia -- blood KW - Methemoglobinemia -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687999756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Sodium+nitrite+potentiates+renal+oxidative+stress+and+injury+in+hemoglobin+exposed+guinea+pigs.&rft.au=Baek%2C+Jin+Hyen%3BZhang%2C+Xiaoyuan%3BWilliams%2C+Matthew+C%3BHicks%2C+Wayne%3BBuehler%2C+Paul+W%3BD%27Agnillo%2C+Felice&rft.aulast=Baek&rft.aufirst=Jin&rft.date=2015-07-03&rft.volume=333&rft.issue=&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2015.04.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-17 N1 - Date created - 2015-06-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2015.04.007 ER - TY - JOUR T1 - Digestibility and Immunoreactivity of Shrimp Extracts Using an In Vitro Digestibility Model with Pepsin and Pancreatin AN - 1787985685; PQ0002928599 AB - Shellfish allergy affects 2% of the adult population in the United States. Identification of allergenic shrimp proteins is needed for improved management and assessment of shrimp allergy. We determined the temporal pepsin and pancreatin stability of total shrimp proteins using simulated physiological digestive conditions in vitro. Gel electrophoresis was used to determine protein stability, whereas immunoreactivity of protease stable proteins was determined using rabbit antigen-specific antibodies. Potential allergenicity of protease stable proteins was determined utilizing human sera from shrimp allergic patients. Total shrimp myofibrillar proteins were pepsin- and pancreatin-stable for up to 1 h after initiating digestion, whereas only pancreatin-stable total shrimp proteins were Immunoglobulin G (IgG) immunoreactive. However, shrimp proteins of 32 and 25 kDa were pepsin and/or pancreatin stable and Immunoglobulin E (IgE) reactive, denoting the stability and potential allergenicity. These findings suggest that this in vitro digestibility model may be useful for the identification of shrimp allergenic proteins that are more resistant to physiologic digestive conditions and may elicit an immunologic response in vivo. JF - Journal of Food Science AU - Toomer, Ondulla T AU - Do, Andrew B AU - Fu, Tong J AU - Williams, Kristina M AD - U.S. Food and Drug Administration, Laurel, MD, 20708, U.S.A. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - T1633 EP - T1639 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 80 IS - 7 SN - 0022-1147, 0022-1147 KW - Environment Abstracts KW - Digestion KW - USA KW - Electrophoresis KW - Decapoda KW - Physiology KW - Proteins KW - Shellfish KW - Allergies KW - ENA 13:Population Planning & Control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787985685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Digestibility+and+Immunoreactivity+of+Shrimp+Extracts+Using+an+In+Vitro+Digestibility+Model+with+Pepsin+and+Pancreatin&rft.au=Toomer%2C+Ondulla+T%3BDo%2C+Andrew+B%3BFu%2C+Tong+J%3BWilliams%2C+Kristina+M&rft.aulast=Toomer&rft.aufirst=Ondulla&rft.date=2015-07-01&rft.volume=80&rft.issue=7&rft.spage=T1633&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2F1750-3841.12917 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Digestion; Electrophoresis; Physiology; Proteins; Shellfish; Allergies; Decapoda; USA DO - http://dx.doi.org/10.1111/1750-3841.12917 ER - TY - JOUR T1 - Comparative Effectiveness of Cardiac Resynchronization Therapy Defibrillators Versus Standard Implantable Defibrillators in Medicare Patients AN - 1768587040; PQ0002267487 AB - Previous analyses have shown that there is lower mortality with cardiac resynchronization therapy defibrillators (CRT-D) in patients with left bundle branch block (LBBB) but demonstrated mixed results in patients without LBBB. We evaluated the comparative effectiveness of CRT-D versus standard implantable defibrillators (ICDs) separately in patients with LBBB and right bundle branch block (RBBB) using Medicare claims data. Medicare records from CRT-D and ICD recipients from 2002 to 2009 that were followed up for up to 48 months were analyzed. We used propensity scores to match patients with ICD to those with CRT-D. In LBBB, 1:1 matching with replacement resulted in 54,218 patients with CRT-D and 20,763 with ICD, and in RBBB, 1:1 matching resulted in 7,298 patients with CRT-D and 7,298 with ICD. In LBBB, CRT-D had a 12% lower risk of heart failure hospitalization or death (hazard ratio [HR] 0.88, 95% confidence interval 0.86 to 0.90) and 5% lower death risk (HR 0.95, 0.92 to 0.97) compared with ICD. In RBBB, CRT-D had a 15% higher risk of heart failure hospitalization or death (HR 1.15, 1.10 to 1.20) and 13% higher death risk (HR 1.13, 1.07 to 1.18). Sensitivity analysis revealed that accounting for covariates not captured in the Medicare database may lead to increased benefit with CRT-D in LBBB and no difference in RBBB. In conclusion, in a large Medicare population, CRT-D was associated with lower mortality in LBBB but higher mortality in RBBB. The absence of certain covariates, in particular those that determine treatment selection, may affect the results of comparative effectiveness studies using claims data. JF - American Journal of Cardiology AU - Zusterzeel, Robbert AU - Canos, Daniel A AU - Sanders, William E AU - Silverman, Henry AU - MaCurdy, Thomas E AU - Worrall, Christopher M AU - Kelman, Jeffrey AU - Marinac-Dabic, Danica AU - Strauss, David G AD - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 79 EP - 84 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 116 IS - 1 SN - 0002-9149, 0002-9149 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Mortality KW - Databases KW - Data processing KW - Defibrillators KW - Risk factors KW - Heart diseases KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1768587040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Cardiology&rft.atitle=Comparative+Effectiveness+of+Cardiac+Resynchronization+Therapy+Defibrillators+Versus+Standard+Implantable+Defibrillators+in+Medicare+Patients&rft.au=Zusterzeel%2C+Robbert%3BCanos%2C+Daniel+A%3BSanders%2C+William+E%3BSilverman%2C+Henry%3BMaCurdy%2C+Thomas+E%3BWorrall%2C+Christopher+M%3BKelman%2C+Jeffrey%3BMarinac-Dabic%2C+Danica%3BStrauss%2C+David+G&rft.aulast=Zusterzeel&rft.aufirst=Robbert&rft.date=2015-07-01&rft.volume=116&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Cardiology&rft.issn=00029149&rft_id=info:doi/10.1016%2Fj.amjcard.2015.03.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Number of references - 25 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Heart; Databases; Mortality; Data processing; Risk factors; Defibrillators; Heart diseases DO - http://dx.doi.org/10.1016/j.amjcard.2015.03.037 ER - TY - JOUR T1 - Improved screening of microcystin genes and toxins in blue-green algal dietary supplements with PCR and a surface plasmon resonance biosensor AN - 1735922478; PQ0002311377 AB - Microcystins (MCs) comprise a group of cyclic heptapeptide toxins that share a common backbone and have two variable l-amino acids that yield at least 21 known analogs of varying potency. These hepatotoxins and potential tumor promoters are produced by certain cyanobacteria, including Microcystis aeruginosa. The cyanobacterium M. aeruginosa blooms in freshwater lakes and can potentially co-occur with other species such as Aphanizomenon flos-aquae, which is targeted and harvested for the production of dietary supplements known as blue-green algae (BGA). BGA supplements are currently marketed in the U.S. and internationally as a product that may elevate mood, increase energy, and alleviate attention deficit hyperactivity disorder. However, the potential for BGA dietary supplements to be contaminated with MCs is of concern, and there are currently no validated methods for detection of MCs in these products. This research focused on establishing screening methods for toxic Microcystis and MCs in BGA supplements. A DNA-based method employing polymerase chain reaction (PCR) was used as a prescreening tool to evaluate the dietary supplements and to detect the presence of toxin genes (i.e., presence of toxic Microcystis). A rapid, sensitive surface plasmon resonance (SPR) biosensor, directed towards recognition of all MC forms, was also developed and validated. This improved SPR biosensor incorporates a commercial Adda-group antibody (Ab) that has the capacity for broader recognition of MCs than previously developed sensors for BGA supplements that rely solely on an arginine-reactive Ab and can quantitate MC levels down to 0.24ng/mL (equivalent to 0.24 mu g per gram of BGA supplement) in less than 10min. Such a rapid, quantitative screening method may allow for further surveillance of BGA products to assist risk assessment efforts, establishment of regulatory guidance levels, and response to potential consumer complaints related to BGA products. The PCR technique and SPR biosensor may be used in concert as prescreening and screening tools, respectively or individually, thereby limiting the number of samples that must be evaluated with confirmatory methods. JF - Harmful Algae AU - Yakes, Betsy Jean AU - Handy, Sara M AU - Kanyuck, Kelsey M AU - DeGrasse, Stacey L AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 9 EP - 16 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 47 SN - 1568-9883, 1568-9883 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Biosensor KW - Blue-green algae KW - Dietary supplements KW - Microcystins KW - PCR KW - Surface plasmon resonance KW - Risk assessment KW - Aphanizomenon flos-aquae KW - Algal blooms KW - Toxicants KW - Sensors KW - Nucleotide sequence KW - Attention deficit hyperactivity disorder KW - Phytoplankton KW - Microcystis aeruginosa KW - Mood KW - Biosensors KW - Microcystis KW - Promoters KW - Lakes KW - Polymerase chain reaction KW - Consumers KW - Algae KW - Screening KW - Freshwater environments KW - Biological poisons KW - Tumors KW - Toxins KW - Antibodies KW - Cyanobacteria KW - surface plasmon resonance KW - Energy KW - DNA KW - O 8010:Books KW - G 07880:Human Genetics KW - Q1 08563:Fishing gear and methods KW - W 30955:Biosensors KW - X 24320:Food Additives & Contaminants KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735922478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Harmful+Algae&rft.atitle=Improved+screening+of+microcystin+genes+and+toxins+in+blue-green+algal+dietary+supplements+with+PCR+and+a+surface+plasmon+resonance+biosensor&rft.au=Yakes%2C+Betsy+Jean%3BHandy%2C+Sara+M%3BKanyuck%2C+Kelsey+M%3BDeGrasse%2C+Stacey+L&rft.aulast=Yakes&rft.aufirst=Betsy&rft.date=2015-07-01&rft.volume=47&rft.issue=&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Harmful+Algae&rft.issn=15689883&rft_id=info:doi/10.1016%2Fj.hal.2015.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Screening; Algal blooms; Sensors; Toxicants; Biological poisons; Nucleotide sequence; DNA; Polymerase chain reaction; Phytoplankton; Risk assessment; Freshwater environments; Microcystins; Attention deficit hyperactivity disorder; Tumors; Toxins; Biosensors; Mood; Promoters; Antibodies; Lakes; surface plasmon resonance; Energy; Dietary supplements; Consumers; Algae; Microcystis; Aphanizomenon flos-aquae; Cyanobacteria; Microcystis aeruginosa DO - http://dx.doi.org/10.1016/j.hal.2015.05.001 ER - TY - JOUR T1 - Design and validation of a qPCR assay for accurate detection and initial serogrouping of Legionella pneumophila in clinical specimens by the ESCMID Study Group for Legionella Infections (ESGLI) AN - 1709182039; PQ0001861573 AB - Prompt detection of Legionella pneumophila is essential for rapid investigation of legionellosis. Furthermore, as the majority of L. pneumophila infections are caused by serogroup 1 (sg1) strains, rapid identification of such strains can be critical in both routine and outbreak scenarios. The ESCMID Study Group for Legionella Infections (ESGLI) was established in 2012 and immediately identified as a priority the validation of a reliable, easy to perform and interpret, cost-effective qPCR assay to standardise the detection of L. pneumophila DNA amongst members. A novel L. pneumophila assay targeting the mip gene was designed and combined with previously published methodologies amplifying the sg1 marker (wzm) and the green fluorescent protein gene (gfp) internal process control. The resulting triplex assay was validated internationally on the three qPCR platforms used by the majority of European Legionella reference laboratories: ABI 7500 (Life Technologies), LightCycler 480 Instrument II (Roche) and Rotor-Gene Q (Qiagen). Clinical and EQA specimens were tested together with a large panel of strains (251 in total) to validate the assay. The assay proved to be 100 % specific for L. pneumophila and sg1 DNA both in silico and in vitro. Efficiency values for mip and wzm assays ranged between 91.97 and 97.69 %. Limit of detection values estimated with 95 % confidence were adopted for mip and wzm assays on all three qPCR platforms. Inhibition was not observed. This study describes a robust assay that could be widely implemented to standardise the molecular detection of L. pneumophila among ESGLI laboratories and beyond. JF - European Journal of Clinical Microbiology & Infectious Diseases AU - Mentasti, M AU - Kese, D AU - Echahidi, F AU - Uldum, SA AU - Afshar, B AU - David, S AU - Mrazek, J AU - Mendonca, R AU - Harrison, T G AU - Chalker, V J AD - Public Health England, 61 Colindale Avenue, London, NW9 5EQ, UK, vicki.chalker@phe.gov.uk Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 1387 EP - 1393 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 34 IS - 7 SN - 0934-9723, 0934-9723 KW - Microbiology Abstracts B: Bacteriology KW - Legionella pneumophila KW - MIP gene KW - DNA KW - Green fluorescent protein KW - Infection KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709182039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.atitle=Design+and+validation+of+a+qPCR+assay+for+accurate+detection+and+initial+serogrouping+of+Legionella+pneumophila+in+clinical+specimens+by+the+ESCMID+Study+Group+for+Legionella+Infections+%28ESGLI%29&rft.au=Mentasti%2C+M%3BKese%2C+D%3BEchahidi%2C+F%3BUldum%2C+SA%3BAfshar%2C+B%3BDavid%2C+S%3BMrazek%2C+J%3BMendonca%2C+R%3BHarrison%2C+T+G%3BChalker%2C+V+J&rft.aulast=Mentasti&rft.aufirst=M&rft.date=2015-07-01&rft.volume=34&rft.issue=7&rft.spage=1387&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Microbiology+%26+Infectious+Diseases&rft.issn=09349723&rft_id=info:doi/10.1007%2Fs10096-015-2363-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 18 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - MIP gene; Green fluorescent protein; DNA; Infection; Legionella pneumophila DO - http://dx.doi.org/10.1007/s10096-015-2363-4 ER - TY - JOUR T1 - A Comparison of the J-1 Visa Waiver and Loan Repayment Programs in the Recruitment and Retention of Physicians in Rural Nebraska AN - 1707500738 AB - Purpose There is a dearth of literature evaluating the effectiveness of programs aimed at recruiting and retaining physicians in rural Nebraska. Taking advantage of the Nebraska Health Professional Tracking System, this study attempts to comparatively assess the effectiveness of the J-1 visa waiver and state loan repayment programs in the recruitment and retention of physicians in rural Nebraska. Methods A mixed methods approach was used. We tracked 240 physicians who enrolled in the J-1 visa waiver and state loan repayment programs between 1996 and 2012 until 2013. In addition, key informant interviews were conducted to obtain perspectives on the recruitment and retention of physicians in rural Nebraska through the 2 programs. Findings Results from multilevel survival regression analysis indicated that physicians enrolled in the J-1 visa waiver program were more likely to leave rural Nebraska when compared with those enrolled in the state loan repayment program. Participants in the qualitative study, however, cautioned against declaring one program as superior over the other, given that the 2 programs addressed different needs for different communities. In addition, results suggested that fostering the integration of physicians and their families into rural communities might be a way of enhancing retention, regardless of program. Conclusion The findings from this study highlight the complexity of recruitment and retention issues in rural Nebraska and suggest the need for more holistic and family-centered approaches to addressing these issues. JF - The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association AU - Opoku, Samuel T AU - Apenteng, Bettye A AU - Lin, Ge AU - Chen, Li-Wu AU - Palm, David AU - Rauner, Thomas AD - Department of Health Policy Management, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, Georgia. ; Department of Health Services & Administration, College of Public Health, University of Nebraska Medical Center (UNMC), Omaha, Nebraska. ; Office of Rural Health, Nebraska Department of Health and Human Services, Omaha, Nebraska. ; Department of Health Policy Management, Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, Georgia. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 300 EP - 309 CY - Washington PB - Wiley Subscription Services, Inc. VL - 31 IS - 3 SN - 0890-765X KW - Public Health And Safety KW - Doctors KW - Effectiveness KW - Rural Communities KW - Health Professions KW - Health Care Services Policy KW - Regression Analysis KW - Qualitative Methods KW - Recruitment KW - Rural Areas KW - Retention KW - Rural communities KW - Tracking KW - Nebraska UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707500738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.atitle=A+Comparison+of+the+J-1+Visa+Waiver+and+Loan+Repayment+Programs+in+the+Recruitment+and+Retention+of+Physicians+in+Rural+Nebraska&rft.au=Opoku%2C+Samuel+T%3BApenteng%2C+Bettye+A%3BLin%2C+Ge%3BChen%2C+Li-Wu%3BPalm%2C+David%3BRauner%2C+Thomas&rft.aulast=Opoku&rft.aufirst=Samuel&rft.date=2015-07-01&rft.volume=31&rft.issue=3&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fjrh.12108 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Date revised - 2015-08-26 N1 - Last updated - 2016-05-16 N1 - SubjectsTermNotLitGenreText - Nebraska DO - http://dx.doi.org/10.1111/jrh.12108 ER - TY - JOUR T1 - Assessment of phthalates/phthalate alternatives in children's toys and childcare articles: Review of the report including conclusions and recommendation of the Chronic Hazard Advisory Panel of the Consumer Product Safety Commission. AN - 1704997578; 25944701 AB - The Consumer Product Safety Commission (CPSC) convened a Chronic Hazard Advisory Panel (CHAP) on Phthalates found in children's toys, and childcare products, and in products used by women of childbearing age. The CHAP conducted a risk assessment on phthalates and phthalate substitutes, and made recommendations to either ban, impose an interim ban, or allow the continued use of phthalates and phthalate substitutes in the above products. After a review of the literature, the evaluation included toxic end points of primary concern, biomonitoring results, extant exposure reconstruction, and epidemiological results. The health end points chosen were associated with the rat phthalate syndrome, which is characterized by malformations of the epididymis, vas deferens, seminal vesicles, prostate, external genitalia (hypospadias), and by cryptorchidism (undescended testes), retention of nipples/areolae, and demasculinization (~incomplete masculinization) of the perineum, resulting in reduced anogenital distance. Risk assessment demonstrated that some phthalates should be permanently banned, removed from the banned list, or remain interim banned. Biomonitoring and toxicology data provided the strongest basis for a mixture risk assessment. In contrast, external exposure data were the weakest and need to be upgraded for epidemiological studies and risk assessments. Such studies would focus on routes and sources. The review presents recommendations and uncertainties. JF - Journal of exposure science & environmental epidemiology AU - Lioy, Paul J AU - Hauser, Russ AU - Gennings, Chris AU - Koch, Holger M AU - Mirkes, Philip E AU - Schwetz, Bernard A AU - Kortenkamp, Andreas AD - Rutgers Environmental and Occupational Health Sciences Institute (EOHSI), Piscataway, New Jersey, USA. ; Harvard School of Public Health, Harvard University, Boston, Massachusetts, USA. ; Icahn School of Medicine at Mount Sinai, New York, New York, USA. ; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bochum, Germany. ; University of Washington (retired), Seattle, Washington, USA. ; US Department of Health and Human Services (retired), Washington, District of Columbia, USA. ; Brunel University, London, UK. PY - 2015 SP - 343 EP - 353 VL - 25 IS - 4 KW - Phthalic Acids KW - 0 KW - Plasticizers KW - phthalic acid KW - 6O7F7IX66E KW - Index Medicus KW - Infant KW - Environmental Monitoring KW - North America KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Humans KW - Europe KW - Child Care KW - Child KW - Female KW - Risk Assessment KW - Pregnancy KW - Child, Preschool KW - Consumer Product Safety KW - Environmental Exposure -- analysis KW - Infant Equipment KW - Environmental Exposure -- adverse effects KW - Play and Playthings KW - Plasticizers -- toxicity KW - Plasticizers -- analysis KW - Phthalic Acids -- toxicity KW - Phthalic Acids -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704997578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Assessment+of+phthalates%2Fphthalate+alternatives+in+children%27s+toys+and+childcare+articles%3A+Review+of+the+report+including+conclusions+and+recommendation+of+the+Chronic+Hazard+Advisory+Panel+of+the+Consumer+Product+Safety+Commission.&rft.au=Lioy%2C+Paul+J%3BHauser%2C+Russ%3BGennings%2C+Chris%3BKoch%2C+Holger+M%3BMirkes%2C+Philip+E%3BSchwetz%2C+Bernard+A%3BKortenkamp%2C+Andreas&rft.aulast=Lioy&rft.aufirst=Paul&rft.date=2015-07-01&rft.volume=25&rft.issue=4&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2015.33 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-15 N1 - Date created - 2015-06-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jes.2015.33 ER - TY - JOUR T1 - The Take-Up of Employer-Sponsored Insurance Among Americans with Mental Disorders: Implications for Health Care Reform AN - 1703894159 AB - Little is known about how take-up of private health insurance coverage differs between those with and without mental disorders. This study seeks to fill this gap by using data from the 2004–2008 Medical Expenditure Panel Survey to examine differences in offers and take-up of employer-sponsored insurance (ESI) among adults aged 27–54. Little evidence that mental disorders are associated with take-up of offers of ESI coverage was found. This suggests that take-up rates in the Affordable Care Act (ACA) marketplaces by those with and without mental disorders may be similar. The ACA is especially important to Americans with mental disorders, many of whom lack access to ESI coverage to pay for mental health treatment either through their own job or through a spouse’s job. JF - Journal of Behavioral Health Services & Research AD - Zuvekas, Samuel H; Center for Financing, Access and Cost Trends, Agency for Healthcare Research and Quality, 540 Gaither Road, Rockville, MD, 20853, USA Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 279 EP - 291 CY - Gaithersburg PB - Springer Science & Business Media VL - 42 IS - 3 SN - 1094-3412 KW - Public Health And Safety KW - Coverage KW - Expenditure KW - Health care KW - Health insurance KW - Insurance KW - Mental health services KW - Psychiatric disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1703894159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=The+Take-Up+of+Employer-Sponsored+Insurance+Among+Americans+with+Mental+Disorders%3A+Implications+for+Health+Care+Reform&rft.au=Zuvekas%2C+Samuel+H&rft.aulast=Zuvekas&rft.aufirst=Samuel&rft.date=2015-07-01&rft.volume=42&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-015-9459-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-08-13 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.1007/s11414-015-9459-6 ER - TY - JOUR T1 - Commentary on the contributions and future role of occupational exposure science in a vision and strategy for the discipline of exposure science AN - 1701497702; PQ0001720914 AB - Exposure science is a holistic concept without prejudice to exposure source. Traditionally, measurements aimed at mitigating environmental exposures have not included exposures in the workplace, instead considering such exposures to be an internal affair between workers and their employers. Similarly, occupational (or industrial) hygiene has not typically accounted for environmental contributions to poor health at work. Many persons spend a significant amount of their lifetime in the workplace, where they maybe exposed to more numerous chemicals at higher levels than elsewhere in their environment. In addition, workplace chemical exposures and other exogenous stressors may increase epigenetic and germline modifications that are passed on to future generations. We provide a brief history of the development of exposure science from its roots in the assessment of workplace exposures, including an appendix where we detail current resources for education and training in exposure science offered through occupational hygiene organizations. We describe existing successful collaborations between occupational and environmental practitioners in the field of exposure science, which may serve as a model for future interactions. Finally, we provide an integrated vision for the field of exposure science, emphasizing interagency collaboration, the need for complete exposure information in epidemiological studies, and the importance of integrating occupational, environmental, and residential assessments. Our goal is to encourage communication and spur additional collaboration between the fields of occupational and environmental exposure assessment. Providing a more comprehensive approach to exposure science is critical to the study of the "exposome", which conceptualizes the totality of exposures throughout a person's life, not only chemical, but also from diet, stress, drugs, infection, and so on, and the individual response. JF - Journal of Exposure Science and Environmental Epidemiology AU - Harper, Martin AU - Weis, Christopher AU - Pleil, Joachim D AU - Blount, Benjamin C AU - Miller, Aubrey AU - Hoover, Mark D AU - Jahn, Steven AD - Exposure Assessment Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road MS-3030, Morgantown, West Virginia, USA Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 381 EP - 387 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 25 IS - 4 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Historical account KW - Mitigation KW - Communication KW - Roots KW - Infection KW - Environmental factors KW - Models KW - Workers KW - epigenetics KW - Vision KW - Drugs KW - Occupational exposure KW - Diets KW - Training KW - Appendix KW - Stress KW - Education KW - Communications KW - Hygiene KW - Occupational health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701497702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Commentary+on+the+contributions+and+future+role+of+occupational+exposure+science+in+a+vision+and+strategy+for+the+discipline+of+exposure+science&rft.au=Harper%2C+Martin%3BWeis%2C+Christopher%3BPleil%2C+Joachim+D%3BBlount%2C+Benjamin+C%3BMiller%2C+Aubrey%3BHoover%2C+Mark+D%3BJahn%2C+Steven&rft.aulast=Harper&rft.aufirst=Martin&rft.date=2015-07-01&rft.volume=25&rft.issue=4&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2014.91 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Diets; Communication; Stress; Roots; Appendix; Infection; Environmental factors; Models; Workers; Vision; epigenetics; Hygiene; Drugs; Occupational exposure; Chemicals; Historical account; Mitigation; Training; Education; Communications; Occupational health DO - http://dx.doi.org/10.1038/jes.2014.91 ER - TY - JOUR T1 - Meta-Analysis of the Reduction of Norovirus and Male-Specific Coliphage Concentrations in Wastewater Treatment Plants AN - 1701493251; PQ0001784720 AB - Human norovirus (NoV) is the leading cause of foodborne illness in the United States and Canada. Wastewater treatment plant (WWTP) effluents impacting bivalve mollusk-growing areas are potential sources of NoV contamination. We have developed a meta-analysis that evaluates WWTP influent concentrations and log10 reductions of NoV genotype I (NoV GI; in numbers of genome copies per liter [gc/liter]), NoV genotype II (NoV GII; in gc/liter), and male-specific coliphage (MSC; in number of PFU per liter), a proposed viral surrogate for NoV. The meta-analysis included relevant data (2,943 measurements) reported in the scientific literature through September 2013 and previously unpublished surveillance data from the United States and Canada. Model results indicated that the mean WWTP influent concentration of NoV GII (3.9 log10 gc/liter; 95% credible interval [CI], 3.5, 4.3 log10 gc/liter) is larger than the value for NoV GI (1.5 log10 gc/liter; 95% CI, 0.4, 2.4 log10 gc/liter), with large variations occurring from one WWTP to another. For WWTPs with mechanical systems and chlorine disinfection, mean log10 reductions were -2.4 log10 gc/liter (95% CI, -3.9, -1.1 log10 gc/liter) for NoV GI, -2.7 log10 gc/liter (95% CI, -3.6, -1.9 log10 gc/liter) for NoV GII, and -2.9 log10 PFU per liter (95% CI, -3.4, -2.4 log10 PFU per liter) for MSCs. Comparable values for WWTPs with lagoon systems and chlorine disinfection were -1.4 log10 gc/liter (95% CI, -3.3, 0.5 log10 gc/liter) for NoV GI, -1.7 log10 gc/liter (95% CI, -3.1, -0.3 log10 gc/liter) for NoV GII, and -3.6 log10 PFU per liter (95% CI, -4.8, -2.4 PFU per liter) for MSCs. Within WWTPs, correlations exist between mean NoV GI and NoV GII influent concentrations and between the mean log10 reduction in NoV GII and the mean log10 reduction in MSCs. JF - Applied and Environmental Microbiology AU - Pouillot, Regis AU - Van Doren, Jane M AU - Woods, Jacquelina AU - Plante, Daniel AU - Smith, Mark AU - Goblick, Gregory AU - Roberts, Christopher AU - Locas, Annie AU - Hajen, Walter AU - Stobo, Jeffrey AD - U.S. Food and Drug Administration, College Park, Maryland, USA, Kevin.Calci@fda.hhs.gov. PY - 2015 SP - 4669 EP - 4681 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 14 SN - 0099-2240, 0099-2240 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Disinfection KW - Data processing KW - Contamination KW - Food KW - Chlorine KW - Norovirus KW - Genotypes KW - Effluents KW - Wastewater treatment KW - Lagoons KW - Models KW - Bivalvia KW - Reviews KW - V 22410:Animal Diseases KW - A 01450:Environmental Pollution & Waste Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701493251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Meta-Analysis+of+the+Reduction+of+Norovirus+and+Male-Specific+Coliphage+Concentrations+in+Wastewater+Treatment+Plants&rft.au=Pouillot%2C+Regis%3BVan+Doren%2C+Jane+M%3BWoods%2C+Jacquelina%3BPlante%2C+Daniel%3BSmith%2C+Mark%3BGoblick%2C+Gregory%3BRoberts%2C+Christopher%3BLocas%2C+Annie%3BHajen%2C+Walter%3BStobo%2C+Jeffrey&rft.aulast=Pouillot&rft.aufirst=Regis&rft.date=2015-07-01&rft.volume=81&rft.issue=14&rft.spage=4669&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00509-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 69 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Genomes; Disinfection; Data processing; Contamination; Food; Reviews; Chlorine; Genotypes; Effluents; Lagoons; Wastewater treatment; Models; Bivalvia; Norovirus DO - http://dx.doi.org/10.1128/AEM.00509-15 ER - TY - JOUR T1 - Characterization of Pre-Antibiotic Era Klebsiella pneumoniae Isolates with Respect to Antibiotic/Disinfectant Susceptibility and Virulence in Galleria mellonella AN - 1701493097; PQ0001784626 AB - The EGD Murray collection consists of approximately 500 clinical bacterial isolates, mainly Enterobacteriaceae, isolated from around the world between 1917 and 1949. A number of these "Murray" isolates have subsequently been identified as Klebsiella pneumoniae. Antimicrobial susceptibility testing of these isolates showed that over 30% were resistant to penicillins due to the presence of diverse blaSHV beta -lactamase genes. Analysis of susceptibility to skin antiseptics and triclosan showed that while the Murray isolates displayed a range of MIC/minimal bactericidal concentration (MBC) values, the mean MIC value was lower than that for more modern K. pneumoniae isolates tested. All Murray isolates contained the cation efflux gene cepA, which is involved in disinfectant resistance, but those that were more susceptible to chlorhexidine were found to have a 9- or 18-bp insertion in this gene. Susceptibility to other disinfectants, e.g., H2O2, in the Murray isolates was comparable to that in modern K. pneumoniae isolates. The Murray isolates were also less virulent in Galleria and had a different complement of putative virulence factors than the modern isolates, with the exception of an isolate related to the modern lineage CC23. More of the modern isolates (41% compared to 8%) are classified as good/very good biofilm formers, but there was overlap in the two populations. This study demonstrated that a significant proportion of the Murray Klebsiella isolates were resistant to penicillins before their routine use. This collection of pre-antibiotic era isolates may provide significant insights into adaptation in K. pneumoniae in relation to biocide susceptibility. JF - Antimicrobial Agents & Chemotherapy AU - Wand, Matthew E AU - Baker, Kate S AU - Benthall, Gabriel AU - McGregor, Hannah AU - McCowen, James WI AU - Deheer-Graham, Ana AU - Sutton, J Mark AD - Public Health England, Microbiology Services Division, Salisbury, Wiltshire, United Kingdom, matthew.wand@phe.gov.uk. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 3966 EP - 3972 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 7 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - beta -Lactamase KW - Skin KW - Chlorhexidine KW - Adaptations KW - virulence factors KW - Antibiotics KW - Minimum inhibitory concentration KW - Penicillin KW - Antimicrobial agents KW - Disinfectants KW - Cations KW - Antiseptics KW - Hydrogen peroxide KW - Biofilms KW - Biocides KW - Galleria mellonella KW - Triclosan KW - Enterobacteriaceae KW - Klebsiella pneumoniae KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701493097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Characterization+of+Pre-Antibiotic+Era+Klebsiella+pneumoniae+Isolates+with+Respect+to+Antibiotic%2FDisinfectant+Susceptibility+and+Virulence+in+Galleria+mellonella&rft.au=Wand%2C+Matthew+E%3BBaker%2C+Kate+S%3BBenthall%2C+Gabriel%3BMcGregor%2C+Hannah%3BMcCowen%2C+James+WI%3BDeheer-Graham%2C+Ana%3BSutton%2C+J+Mark&rft.aulast=Wand&rft.aufirst=Matthew&rft.date=2015-07-01&rft.volume=59&rft.issue=7&rft.spage=3966&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.05009-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 43 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Adaptations; Chlorhexidine; Skin; beta -Lactamase; virulence factors; Antibiotics; Minimum inhibitory concentration; Penicillin; Antimicrobial agents; Disinfectants; Cations; Hydrogen peroxide; Antiseptics; Biocides; Biofilms; Triclosan; Galleria mellonella; Enterobacteriaceae; Klebsiella pneumoniae DO - http://dx.doi.org/10.1128/AAC.05009-14 ER - TY - JOUR T1 - Chromatin Changes at the PPAR- gamma 2 Promoter During Bone Marrow-Derived Multipotent Stromal Cell Culture Correlate With Loss of Gene Activation Potential AN - 1701477420; PQ0001681712 AB - Bone marrow-derived multipotent stromal cells (BM-MSCs) display a broad range of therapeutically valuable properties, including the capacity to form skeletal tissues and dampen immune system responses. However, to use BM-MSCs in a clinical setting, amplification is required, which may introduce epigenetic changes that affect biological properties. Here we used chromatin immunoprecipitation to compare post-translationally modified histones at a subset of gene promoters associated with developmental and environmental plasticity in BM-MSCs from multiple donors following culture expansion. At many locations, we observed localization of both transcriptionally permissive (H3K4me3) and repressive (H3K27me3) histone modifications. These chromatin signatures were consistent among BM-MSCs from multiple donors. Since promoter activity depends on the relative levels of H3K4me3 and H3K27me3, we examined the ratio of H3K4me3 to H3K27me3 (K4/K27) at promoters during culture expansion. The H3K4me3 to H3K27me3 ratios were maintained at most assayed promoters over time. The exception was the adipose-tissue specific promoter for the PPAR- gamma 2 isoform of PPAR- gamma , which is a critical positive regulator of adipogenesis. At PPAR- gamma 2, we observed a change in K4/K27 levels favoring the repressed chromatin state during culture. This change correlated with diminished promoter activity in late passage cells exposed to adipogenic stimuli. In contrast to BM-MSCs and osteoblasts, lineage-restricted preadipocytes exhibited levels of H3K4me3 and H3K27me3 that favored the permissive chromatin state at PPAR- gamma 2. These results demonstrate that locus-specific changes in H3K4me3 and H3K27me3 levels can occur during BM-MSC culture that may affect their properties. Stem Cells 2015; 33:2169-2181 JF - Stem Cells AU - Lynch, Patrick J AU - Thompson, Elaine E AU - McGinnis, Kathleen AU - Rovira Gonzalez, Yazmin I AU - Lo Surdo, Jessica AU - Bauer, Steven R AU - Hursh, Deborah A AD - Cellular and Tissue Therapies Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, US Food and Drug Administration, Bethesda, Maryland, USA. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 2169 EP - 2181 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 33 IS - 7 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Plasticity (developmental) KW - Histones KW - stromal cells KW - Chromatin KW - Immune system KW - Preadipocytes KW - Immunoprecipitation KW - Bone marrow KW - Transcription KW - Cell culture KW - Promoters KW - Osteoblasts KW - Stem cells KW - Post-translation KW - epigenetics KW - adipogenesis KW - Transcription activation KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701477420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Chromatin+Changes+at+the+PPAR-+gamma+2+Promoter+During+Bone+Marrow-Derived+Multipotent+Stromal+Cell+Culture+Correlate+With+Loss+of+Gene+Activation+Potential&rft.au=Lynch%2C+Patrick+J%3BThompson%2C+Elaine+E%3BMcGinnis%2C+Kathleen%3BRovira+Gonzalez%2C+Yazmin+I%3BLo+Surdo%2C+Jessica%3BBauer%2C+Steven+R%3BHursh%2C+Deborah+A&rft.aulast=Lynch&rft.aufirst=Patrick&rft.date=2015-07-01&rft.volume=33&rft.issue=7&rft.spage=2169&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/10.1002%2Fstem.1967 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Plasticity (developmental); Histones; Chromatin; stromal cells; Immune system; Preadipocytes; Bone marrow; Immunoprecipitation; Transcription; Cell culture; Osteoblasts; Promoters; Stem cells; Post-translation; epigenetics; adipogenesis; Transcription activation DO - http://dx.doi.org/10.1002/stem.1967 ER - TY - JOUR T1 - Phase I trial of systemic intravenous infusion of interleukin-13-Pseudomonas exotoxin in patients with metastatic adrenocortical carcinoma. AN - 1696885993; 25767039 AB - Adrenocortical carcinoma (ACC) is a rare but lethal malignancy without effective current therapy for metastatic disease. IL-13-PE is a recombinant cytotoxin consisting of human interleukin-13 (IL-13) and a truncated form of Pseudomonas exotoxin A (PE). The main objectives of this Phase I dose-escalation trial were to assess the maximum-tolerated dose (MTD), safety, and pharmacokinetics (PK) of IL-13-PE in patients with metastatic ACC. Eligible patients had confirmed IL-13 receptor alpha 2 (IL-13Rα2) expressions in their tumors. IL-13-PE at dose of 1-2 μg/kg was administered intravenously (IV) on day 1, 3, and 5 in a 4-week cycle. Six patients received 1 μg/kg and two patients received 2 μg/kg of IL-13-PE. Dose-limiting toxicity was observed at 2 μg/kg, at which patients exhibited thrombocytopenia and renal insufficiency without requiring dialysis. PK analysis demonstrated that at MTD, the mean maximum serum concentration (Cmax ) of IL-13-PE was 21.0 ng/mL, and the terminal half-life of IL-13-PE was 30-39 min. Two (25%) of the eight patients had baseline neutralizing antibodies against PE. Three (75%) of the remaining four tested patients developed neutralizing antibodies against IL-13-PE within 14-28 days of initial treatment. Of the five patients treated at MTD and assessed for response, one patient had stable disease for 5.5 months before disease progression; the others progressed within 1-2 months. In conclusion, systemic IV administration of IL-13-PE is safe at 1 μg/kg. All tested patients developed high levels of neutralizing antibodies during IL-13-PE treatment. Use of strategies for immunodepletion before IL-13-PE treatment should be considered in future trials. © 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. JF - Cancer medicine AU - Liu-Chittenden, Yi AU - Jain, Meenu AU - Kumar, Parag AU - Patel, Dhaval AU - Aufforth, Rachel AU - Neychev, Vladimir AU - Sadowski, Samira AU - Gara, Sudheer K AU - Joshi, Bharat H AU - Cottle-Delisle, Candice AU - Merkel, Roxanne AU - Yang, Lily AU - Miettinen, Markku AU - Puri, Raj K AU - Kebebew, Electron AD - Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. ; Clinical Pharmacokinetics Research Laboratory, Clinical Center Pharmacy Department, National Institutes of Health, Bethesda, Maryland. ; Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. ; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 1060 EP - 1068 VL - 4 IS - 7 KW - Antibodies, Neutralizing KW - 0 KW - Antineoplastic Agents KW - Bacterial Toxins KW - Exotoxins KW - Interleukin-13 KW - Recombinant Fusion Proteins KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Phase I KW - systemic administration KW - metastatic adrenocortical carcinoma KW - IL-13-PE KW - pharmacokinetics KW - maximum-tolerated dose KW - Young Adult KW - Infusions, Intravenous KW - Humans KW - Aged KW - Adult KW - Treatment Outcome KW - Neoplasm Metastasis KW - Middle Aged KW - Antibodies, Neutralizing -- blood KW - Maximum Tolerated Dose KW - Adolescent KW - Retreatment KW - Female KW - Male KW - Adrenocortical Carcinoma -- therapy KW - Recombinant Fusion Proteins -- pharmacokinetics KW - Recombinant Fusion Proteins -- adverse effects KW - Antineoplastic Agents -- administration & dosage KW - Antineoplastic Agents -- pharmacokinetics KW - Adrenal Cortex Neoplasms -- therapy KW - Recombinant Fusion Proteins -- administration & dosage KW - Adrenocortical Carcinoma -- drug therapy KW - Antineoplastic Agents -- adverse effects KW - Adrenocortical Carcinoma -- pathology KW - Adrenal Cortex Neoplasms -- pathology KW - Adrenal Cortex Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1696885993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+medicine&rft.atitle=Phase+I+trial+of+systemic+intravenous+infusion+of+interleukin-13-Pseudomonas+exotoxin+in+patients+with+metastatic+adrenocortical+carcinoma.&rft.au=Liu-Chittenden%2C+Yi%3BJain%2C+Meenu%3BKumar%2C+Parag%3BPatel%2C+Dhaval%3BAufforth%2C+Rachel%3BNeychev%2C+Vladimir%3BSadowski%2C+Samira%3BGara%2C+Sudheer+K%3BJoshi%2C+Bharat+H%3BCottle-Delisle%2C+Candice%3BMerkel%2C+Roxanne%3BYang%2C+Lily%3BMiettinen%2C+Markku%3BPuri%2C+Raj+K%3BKebebew%2C+Electron&rft.aulast=Liu-Chittenden&rft.aufirst=Yi&rft.date=2015-07-01&rft.volume=4&rft.issue=7&rft.spage=1060&rft.isbn=&rft.btitle=&rft.title=Cancer+medicine&rft.issn=2045-7634&rft_id=info:doi/10.1002%2Fcam4.449 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-06 N1 - Date created - 2015-07-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Cancer Res Clin Oncol. 2010 Jun;136(6):839-46 [19916021] Neurosurgery. 2007 Nov;61(5):1031-7; discussion 1037-8 [18091279] Nat Rev Endocrinol. 2011 Jun;7(6):323-35 [21386792] Clin Cancer Res. 2011 Sep 15;17(18):5858-66 [21813634] Hum Gene Ther Methods. 2012 Apr;23(2):137-47 [22612657] J Clin Oncol. 2007 Mar 1;25(7):837-44 [17327604] Cancer. 2006 Sep 15;107(6):1407-18 [16902988] Mol Cancer Ther. 2008 Jun;7(6):1579-87 [18566228] Cancer. 2008 Dec 1;113(11):3130-6 [18973179] Best Pract Res Clin Endocrinol Metab. 2009 Apr;23(2):273-89 [19500769] Clin Cancer Res. 2010 Jan 15;16(2):577-86 [20068108] Cancer. 2012 Nov 15;118(22):5698-708 [22570059] Eur J Cancer. 2013 Jul;49(11):2579-86 [23561851] Cancer Res. 2000 Mar 1;60(5):1168-72 [10728667] Mol Med. 2000 May;6(5):440-9 [10952023] Clin Cancer Res. 2002 Jun;8(6):1948-56 [12060640] Clin Cancer Res. 2003 Dec 15;9(17):6381-8 [14695138] J Biol Chem. 1995 Jul 14;270(28):16775-80 [7622490] Blood. 1996 May 15;87(10):4333-9 [8639793] Clin Cancer Res. 1997 Feb;3(2):151-6 [9815666] Protein Expr Purif. 2005 Feb;39(2):189-98 [15642470] Nat Med. 2006 Jan;12(1):99-106 [16327802] World J Surg. 2006 May;30(5):872-8 [16680602] Technol Cancer Res Treat. 2006 Jun;5(3):239-50 [16700620] Neurosurg Focus. 2006;20(4):E15 [16709020] Neuro Oncol. 2010 Aug;12(8):871-81 [20511192] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cam4.449 ER - TY - JOUR T1 - Amsterdam's STI/HIV programme: an innovative strategy to achieve and enhance the participation of migrant community-based organisations AN - 1695993925; 4687892 JF - Health education journal AU - Wagemakers, Annemarie AU - Husen, Gwen van AU - Barrett, Jennifer AU - Koelen, Maria AD - Wageningen University ; Public Health Service Amsterdam ; University of South Wales Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 411 EP - 423 VL - 74 IS - 4 SN - 0017-8969, 0017-8969 KW - Sociology KW - Community KW - Evaluation KW - Community organization KW - Innovation KW - AIDS KW - Netherlands KW - HIV KW - Migrants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1695993925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+education+journal&rft.atitle=Amsterdam%27s+STI%2FHIV+programme%3A+an+innovative+strategy+to+achieve+and+enhance+the+participation+of+migrant+community-based+organisations&rft.au=Wagemakers%2C+Annemarie%3BHusen%2C+Gwen+van%3BBarrett%2C+Jennifer%3BKoelen%2C+Maria&rft.aulast=Wagemakers&rft.aufirst=Annemarie&rft.date=2015-07-01&rft.volume=74&rft.issue=4&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Health+education+journal&rft.issn=00178969&rft_id=info:doi/10.1177%2F0017896914542665 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-07-14 N1 - Last updated - 2015-07-14 N1 - SubjectsTermNotLitGenreText - 4551; 5703 3617 6220; 8037; 2603; 2613 11878 9003; 482 3617 6220; 6564 12622; 275 462 129 DO - http://dx.doi.org/10.1177/0017896914542665 ER - TY - JOUR T1 - Regulatory Forum Opinion Piece*: Transgenic/Alternative Carcinogenicity Assays: A Retrospective Review of Studies Submitted to CDER/FDA 1997-2014. AN - 1694509093; 25630682 AB - The International Conference on Harmonization (ICH; S1B of 1997) allows a second species carcinogenicity study to be an alternative to one of the traditional 2-year studies. In the past 17 years, the FDA's Center for Drug Evaluation and Research's (CDER) Executive Carcinogenicity Assessment Committee received 269 alternative carcinogenicity assay protocols for review. This committee's recommendations regarding choice of animal model and dose selection are generally followed by sponsors conducting these studies to increase the acceptability of such studies. The P53(+/-) assay is generally considered appropriate for genotoxic products, and the TgRasH2 assay is appropriate for non-genotoxic or genotoxic drugs. In the United States, the TgAC assay is not used any more and the animals are no longer available. The TgAC assay can detect both tumor promoters and complete carcinogens, and consequently more than half of the dermal TgAC assays resulted in a positive assessment. Currently, more than 75% of mouse carcinogenicity studies are conducted in TgRasH2 mice. Behavior of genotoxic and non-genotoxic drugs in the various assays is reviewed. © 2015 by The Author(s). JF - Toxicologic pathology AU - Jacobs, Abigail C AU - Brown, Paul C AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA Abigail.Jacobs@fda.hhs.gov. ; Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 605 EP - 610 VL - 43 IS - 5 KW - Index Medicus KW - carcinogenicity KW - transgenic KW - regulatory KW - FDA. KW - United States KW - Animals KW - United States Food and Drug Administration KW - Retrospective Studies KW - Mice KW - Mice, Transgenic KW - Carcinogenicity Tests -- standards KW - Drug Evaluation -- legislation & jurisprudence KW - Carcinogenicity Tests -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694509093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Regulatory+Forum+Opinion+Piece*%3A+Transgenic%2FAlternative+Carcinogenicity+Assays%3A+A+Retrospective+Review+of+Studies+Submitted+to+CDER%2FFDA+1997-2014.&rft.au=Jacobs%2C+Abigail+C%3BBrown%2C+Paul+C&rft.aulast=Jacobs&rft.aufirst=Abigail&rft.date=2015-07-01&rft.volume=43&rft.issue=5&rft.spage=605&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623314566241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-21 N1 - Date created - 2015-07-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623314566241 ER - TY - JOUR T1 - Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin. AN - 1693184156; 25837581 AB - Stromal interaction molecule 1 (STIM1) is a Ca(2+) sensor protein that initiates store-operated calcium entry (SOCE). STIM1 is known to be involved in the chemoattractant signaling pathway for FPR1 in cell lines, but its role in in vivo functioning of neutrophils is unclear. Plaque-type psoriasis is a chronic inflammatory skin disorder associated with chemoattractants driving neutrophils into the epidermis. We investigated the involvement of STIM1 in neutrophil chemotaxis in vitro, as well as during chronic psoriatic inflammation. To this end, we used conditional knockout (KO) mice lacking STIM1 in cells of myeloid lineage (STIM1(fl/fl) LysM-cre). We demonstrate that STIM1 is required for chemotaxis because of multiple chemoattractants in mouse neutrophils in vitro. Using an imiquimod-induced psoriasis-like skin model, we show that KO mice had less neutrophil infiltration in the epidermis than controls, whereas neither chemoattractant production in the epidermis nor macrophage migration was decreased. KO mice displayed a more rapid reversal of the outward signs of psoriasis (plaques). Thus, KO of STIM1 impairs neutrophil contribution to psoriatic inflammation. Our data provide new insights to our understanding of how STIM1 orchestrates the cellular behavior underlying chemotaxis and illustrate the important role of SOCE in a disease-related pathologic model. © FASEB. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Steinckwich, Natacha AU - Myers, Page AU - Janardhan, Kyathanahalli S AU - Flagler, Norris D AU - King, Debra AU - Petranka, John G AU - Putney, James W AD - *Signal Transduction Laboratory, Comparative Medicine Branch, Integrated Laboratory Systems, Incorporated, Cellular and Molecular Pathology Branch,National Toxicology Program, and Special Techniques Group, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA. ; *Signal Transduction Laboratory, Comparative Medicine Branch, Integrated Laboratory Systems, Incorporated, Cellular and Molecular Pathology Branch,National Toxicology Program, and Special Techniques Group, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA putney@niehs.nih.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 3003 EP - 3013 VL - 29 IS - 7 KW - Aminoquinolines KW - 0 KW - Calcium Channels KW - Membrane Proteins KW - Neoplasm Proteins KW - RNA, Small Interfering KW - STIM1 protein, human KW - Stim1 protein, mouse KW - Stromal Interaction Molecule 1 KW - imiquimod KW - P1QW714R7M KW - Index Medicus KW - calcium signaling KW - leukocyte migration KW - chronic inflammatory disease KW - Animals KW - Skin -- physiopathology KW - Neoplasm Proteins -- antagonists & inhibitors KW - HL-60 Cells KW - Humans KW - Skin -- pathology KW - Disease Models, Animal KW - RNA, Small Interfering -- genetics KW - Neutrophil Infiltration -- physiology KW - Mice KW - Membrane Proteins -- genetics KW - Chemotaxis, Leukocyte -- physiology KW - Mice, Knockout KW - Aminoquinolines -- toxicity KW - Neoplasm Proteins -- physiology KW - Neoplasm Proteins -- genetics KW - In Vitro Techniques KW - Membrane Proteins -- antagonists & inhibitors KW - Signal Transduction KW - Membrane Proteins -- physiology KW - Calcium Channels -- deficiency KW - Neutrophils -- pathology KW - Calcium Channels -- physiology KW - Psoriasis -- physiopathology KW - Psoriasis -- pathology KW - Neutrophils -- physiology KW - Calcium Channels -- genetics KW - Psoriasis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1693184156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=Role+of+the+store-operated+calcium+entry+protein%2C+STIM1%2C+in+neutrophil+chemotaxis+and+infiltration+into+a+murine+model+of+psoriasis-inflamed+skin.&rft.au=Steinckwich%2C+Natacha%3BMyers%2C+Page%3BJanardhan%2C+Kyathanahalli+S%3BFlagler%2C+Norris+D%3BKing%2C+Debra%3BPetranka%2C+John+G%3BPutney%2C+James+W&rft.aulast=Steinckwich&rft.aufirst=Natacha&rft.date=2015-07-01&rft.volume=29&rft.issue=7&rft.spage=3003&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/10.1096%2Ffj.14-265215 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-14 N1 - Date created - 2015-07-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1978 May;75(5):2458-62 [276884] J Invest Dermatol. 2002 Jan;118(1):49-54 [11851875] J Immunol. 2011 Feb 15;186(4):2182-91 [21239714] Toxicol Pathol. 2011 Feb;39(2):435-48 [21300792] J Immunol. 2011 Jul 1;187(1):472-81 [21632714] J Immunol. 2012 Jan 1;188(1):462-9 [22131335] Cell Physiol Biochem. 2012;30(1):221-37 [22759969] Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C490-8 [22673622] Blood. 2014 Apr 3;123(14):2238-49 [24493668] Oncogene. 2014 May 1;33(18):2307-16 [23686305] J Cell Biol. 1990 Jan;110(1):43-52 [2295684] J Cell Biol. 1991 Mar;112(6):1249-57 [1900302] Cell. 1996 Feb 9;84(3):359-69 [8608589] Cell. 1996 Feb 9;84(3):371-9 [8608590] Biochem J. 1996 Jul 15;317 ( Pt 2):403-9 [8713065] Cell. 1996 Nov 15;87(4):601-6 [8929529] Biochem Biophys Res Commun. 1997 Jan 13;230(2):258-61 [9016761] Nature. 2006 May 11;441(7090):179-85 [16582901] Science. 2006 May 26;312(5777):1220-3 [16645049] Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9357-62 [16751269] Curr Med Chem. 2007;14(6):681-7 [17346155] Ann Biomed Eng. 2008 Apr;36(4):632-46 [18278555] Nat Immunol. 2008 Apr;9(4):432-43 [18327260] Methods. 2008 Nov;46(3):204-12 [18929662] J Immunol. 2009 May 1;182(9):5836-45 [19380832] Biochem Pharmacol. 2009 Sep 1;78(5):504-13 [19433064] N Engl J Med. 2009 Jul 30;361(5):496-509 [19641206] Blood. 2010 Jan 21;115(3):657-66 [19965684] J Leukoc Biol. 2010 Jul;88(1):57-68 [20400677] Transgenic Res. 1999 Aug;8(4):265-77 [10621974] Pharmacol Rev. 2000 Mar;52(1):145-76 [10699158] J Invest Dermatol. 2000 May;114(5):976-83 [10771480] J Am Acad Dermatol. 2000 Aug;43(2 Pt 2):391-5 [10901732] Blood. 2000 Dec 1;96(12):3816-22 [11090065] Nat Rev Rheumatol. 2010 Dec;6(12):704-14 [20877306] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1096/fj.14-265215 ER - TY - JOUR T1 - Risk of cancer among firefighters in California, 1988-2007 AN - 1691292299; PQ0001650567 AB - Background Most studies of firefighter cancer risks were conducted prior to 1990 and do not reflect risk from advances in building materials. Methods A case-control study using California Cancer Registry data (1988-2007) was conducted to evaluate the risk of cancer among firefighters, stratified by race. Results This study identified 3,996 male firefighters with cancer. Firefighters were found to have a significantly elevated risk for melanoma (odds ratio [OR]=1.8; 95% confidence interval [CI] 1.4-2.1), multiple myeloma (OR 1.4; 95%CI 1.0-1.8), acute myeloid leukemia (OR 1.4; 95%CI 1.0-2.0), and cancers of the esophagus (OR 1.6; 95%CI 1.2-2.1), prostate (OR 1.5; 95%CI 1.3-1.7), brain (OR 1.5; 95%CI 1.2-2.0), and kidney (OR 1.3; 95%CI 1.0-1.6). Conclusions In addition to observing cancer findings consistent with previous research, this study generated novel findings for firefighters with race/ethnicity other than white. It provides additional evidence to support the association between firefighting and several specific cancers. Am. J. Ind. Med. 58:715-729, 2015. copyright 2015 This article has been contributed to by US Government employees and their work is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Tsai, Rebecca J AU - Luckhaupt, Sara E AU - Schumacher, Pam AU - Cress, Rosemary D AU - Deapen, Dennis M AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 715 EP - 729 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 7 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Health risks KW - Leukemia KW - Multiple myeloma KW - Firefighter services KW - Brain KW - Kidney KW - Construction materials KW - USA, California KW - Cancer KW - Ethnic groups KW - Melanoma KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691292299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Risk+of+cancer+among+firefighters+in+California%2C+1988-2007&rft.au=Tsai%2C+Rebecca+J%3BLuckhaupt%2C+Sara+E%3BSchumacher%2C+Pam%3BCress%2C+Rosemary+D%3BDeapen%2C+Dennis+M%3BCalvert%2C+Geoffrey+M&rft.aulast=Tsai&rft.aufirst=Rebecca&rft.date=2015-07-01&rft.volume=58&rft.issue=7&rft.spage=715&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22466 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2015-07-23 N1 - SubjectsTermNotLitGenreText - Leukemia; Health risks; Multiple myeloma; Firefighter services; Kidney; Brain; Construction materials; Ethnic groups; Cancer; Melanoma; USA, California DO - http://dx.doi.org/10.1002/ajim.22466 ER - TY - JOUR T1 - Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells. AN - 1691016245; 25870318 AB - The use of usnic acid as a weight loss agent is a safety concern due to reports of acute liver failure in humans. Previously we demonstrated that usnic acid induces apoptosis and cytotoxicity in hepatic HepG2 cells. We also demonstrated that usnic acid induces autophagy as a survival mechanism against its cytotoxicity. In this study, we investigated and characterized further molecular mechanisms underlying the toxicity of usnic acid in HepG2 cells. We found that usnic acid causes endoplasmic reticulum (ER) stress demonstrated by the increased expression of typical ER stress markers, including CHOP, ATF-4, p-eIF2α, and spliced XBP1. Usnic acid inhibited the secretion of Gaussia luciferase measured by an ER stress reporter assay. An ER stress inhibitor 4-phenylbutyrate attenuated usnic acid-induced apoptosis. Moreover, usnic acid significantly increased the cytosolic free Ca(2+) concentration. Usnic acid increased the expression of calcium release-activated calcium channel protein 1 (CRAM1 or ORAI1) and stromal interaction molecule 1, two key components of store-operated calcium entry (SOCE), which is the major Ca(2+) influx pathway in non-excitable cells, this finding was also confirmed in primary rat hepatocytes. Furthermore, knockdown of ORAI1 prevented ER stress and ATP depletion in response to usnic acid. In contrast, overexpression of ORAI1 increased ER stress and ATP depletion caused by usnic acid. Taken together, our results suggest that usnic acid disturbs calcium homeostasis, induces ER stress, and that usnic acid-induced cellular damage occurs at least partially via activation of the Ca(2+) channel of SOCE. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Chen, Si AU - Zhang, Zhuhong AU - Wu, Yuanfeng AU - Shi, Qiang AU - Yan, Hua AU - Mei, Nan AU - Tolleson, William H AU - Guo, Lei AD - *Division of Biochemical Toxicology, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, Tianjin Medical University General Hospital, Tianjin 300052, China and Division of Systems Biology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079. ; *Division of Biochemical Toxicology, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, Tianjin Medical University General Hospital, Tianjin 300052, China and Division of Systems Biology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079 *Division of Biochemical Toxicology, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, Tianjin Medical University General Hospital, Tianjin 300052, China and Division of Systems Biology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079. ; *Division of Biochemical Toxicology, Division of Genetic and Molecular Toxicology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079, Tianjin Medical University General Hospital, Tianjin 300052, China and Division of Systems Biology, National Center for Toxicological Research/U.S. FDA, Jefferson, AR 72079 lei.guo@fda.hhs.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 116 EP - 126 VL - 146 IS - 1 KW - Benzofurans KW - 0 KW - usnic acid KW - 0W584PFJ77 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - apoptosis KW - liver toxicity KW - store operated calcium entry KW - ER stress KW - Hep G2 Cells KW - Humans KW - Endoplasmic Reticulum -- metabolism KW - Calcium -- metabolism KW - Benzofurans -- toxicity KW - Stress, Physiological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691016245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Endoplasmic+Reticulum+Stress+and+Store-Operated+Calcium+Entry+Contribute+to+Usnic+Acid-Induced+Toxicity+in+Hepatic+Cells.&rft.au=Chen%2C+Si%3BZhang%2C+Zhuhong%3BWu%2C+Yuanfeng%3BShi%2C+Qiang%3BYan%2C+Hua%3BMei%2C+Nan%3BTolleson%2C+William+H%3BGuo%2C+Lei&rft.aulast=Chen&rft.aufirst=Si&rft.date=2015-07-01&rft.volume=146&rft.issue=1&rft.spage=116&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv075 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-07 N1 - Date created - 2015-06-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv075 ER - TY - JOUR T1 - Comparative Risk Assessment of Formulation Changes in Generic Drug Products: A Pharmacology/Toxicology Perspective. AN - 1691016234; 26101235 AB - This review highlights general toxicology concerns caused by formulation differences between generic and innovator drugs. It underscores the importance of a scientific, clinically oriented, evidence-based comparative safety evaluation procedure for generic drugs and discusses representative case studies from a pharmacology-toxicology perspective. For consideration by generic drug industry stakeholders, this article provides an overview of comparative risk assessments for generic drug products. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Rayavarapu, Sree AU - Braithwaite, Elena AU - Dorsam, Robert AU - Osterhout, James AU - Furlong, Lesley-Anne AU - Shetty, Daiva AU - Peters, John R AD - Division of Clinical Review, Office of Bioequivalence, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993 sree.rayavarapu@fda.hhs.gov. ; Division of Clinical Review, Office of Bioequivalence, Office of Generic Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 2 EP - 10 VL - 146 IS - 1 KW - Drugs, Generic KW - 0 KW - Excipients KW - Index Medicus KW - residual solvents KW - excipients KW - toxicity KW - impurities KW - generics KW - reference listed drug KW - Risk Assessment KW - Drugs, Generic -- adverse effects KW - Chemistry, Pharmaceutical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691016234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Comparative+Risk+Assessment+of+Formulation+Changes+in+Generic+Drug+Products%3A+A+Pharmacology%2FToxicology+Perspective.&rft.au=Rayavarapu%2C+Sree%3BBraithwaite%2C+Elena%3BDorsam%2C+Robert%3BOsterhout%2C+James%3BFurlong%2C+Lesley-Anne%3BShetty%2C+Daiva%3BPeters%2C+John+R&rft.aulast=Rayavarapu&rft.aufirst=Sree&rft.date=2015-07-01&rft.volume=146&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv074 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-07 N1 - Date created - 2015-06-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv074 ER - TY - JOUR T1 - Quantitative Assessment of MRI T2 Response to Kainic Acid Neurotoxicity in Rats in vivo. AN - 1691016229; 25904105 AB - The aim of this study was to assess quantitative changes in T2 relaxation using magnetic resonance imaging approaches in rats exposed to kainic acid to assess the utility of such endpoints as biomarkers of neurotoxicity. Quantitative T2 mapping was performed in 21 rats before and 2, 24, and 48 h after a single ip injection of 10 mg/kg of kainic acid. Three methods of quantifying T2 changes were explored: (1) Thresholding: all voxels exhibiting T2 ≤ 72 ms were designated normal tissue, whereas voxels exhibiting T2 > 72 ms were designated as lesioned tissue; (2) Statistical mapping: T2 maps obtained after treatment were statistically compared with averaged "baseline" maps, voxel-by-voxel; (3) Within-subject difference from baseline: for each individual the baseline T2 map was subtracted from the T2 map obtained after treatment. Based on the follow-up histopathological response there were 9 responders, 7 nonresponders, and 5 animals were not classified due to early sacrifice at 2 h which was too soon after treatment to detect any morphological evidence. The "thresholding" method (1) detected differences between groups only at the later time point of 48 h, the "statistical mapping" approach (2) detected differences 24 and 48 h after treatment, and the "within-subject difference from baseline" method (3) detected statistically significant differences between groups at each time point (2, 24, and 48 h). T2 mapping provides an easily quantifiable biomarker and the quantification method employing the use of the same animal as its own control provides the most sensitive metrics. Published by Oxford University Press on behalf of the Society of Toxicology 2015. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Liachenko, Serguei AU - Ramu, Jaivijay AU - Konak, Tetyana AU - Paule, Merle G AU - Hanig, Joseph AD - *Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas and Office of Testing and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak, Maryland Serguei.liachenko@fda.hhs.gov. ; *Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas and Office of Testing and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, White Oak, Maryland. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 183 EP - 191 VL - 146 IS - 1 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - toxicity KW - MRI KW - T2 map KW - quantification KW - kainic acid KW - registration KW - rat KW - brain KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Male KW - Magnetic Resonance Imaging -- methods KW - Nervous System -- drug effects KW - Kainic Acid -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691016229?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Quantitative+Assessment+of+MRI+T2+Response+to+Kainic+Acid+Neurotoxicity+in+Rats+in+vivo.&rft.au=Liachenko%2C+Serguei%3BRamu%2C+Jaivijay%3BKonak%2C+Tetyana%3BPaule%2C+Merle+G%3BHanig%2C+Joseph&rft.aulast=Liachenko&rft.aufirst=Serguei&rft.date=2015-07-01&rft.volume=146&rft.issue=1&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfv083 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-07 N1 - Date created - 2015-06-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfv083 ER - TY - JOUR T1 - Manganese concentrations in soil and settled dust in an area with historic ferroalloy production. AN - 1690213007; 25335867 AB - Ferroalloy production can release a number of metals into the environment, of which manganese (Mn) is of major concern. Other elements include lead, iron, zinc, copper, chromium, and cadmium. Mn exposure derived from settled dust and suspended aerosols can cause a variety of adverse neurological effects to chronically exposed individuals. To better estimate the current levels of exposure, this study quantified the metal levels in dust collected inside homes (n=85), outside homes (n=81), in attics (n=6), and in surface soil (n=252) in an area with historic ferroalloy production. Metals contained in indoor and outdoor dust samples were quantified using inductively coupled plasma optical emission spectroscopy, whereas attic and soil measurements were made with a X-ray fluorescence instrument. Mean Mn concentrations in soil (4600 μg/g) and indoor dust (870 μg/g) collected within 0.5 km of a plant exceeded levels previously found in suburban and urban areas, but did decrease outside 1.0 km to the upper end of background concentrations. Mn concentrations in attic dust were ~120 times larger than other indoor dust levels, consistent with historical emissions that yielded high airborne concentrations in the region. Considering the potential health effects that are associated with chronic Mn inhalation and ingestion exposure, remediation of soil near the plants and frequent, on-going hygiene indoors may decrease residential exposure and the likelihood of adverse health effects. JF - Journal of exposure science & environmental epidemiology AU - Pavilonis, Brian T AU - Lioy, Paul J AU - Guazzetti, Stefano AU - Bostick, Benjamin C AU - Donna, Filippo AU - Peli, Marco AU - Zimmerman, Neil J AU - Bertrand, Patrick AU - Lucas, Erika AU - Smith, Donald R AU - Georgopoulos, Panos G AU - Mi, Zhongyuan AU - Royce, Steven G AU - Lucchini, Roberto G AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. ; Public Health Service, Reggio Emilia, Italy. ; Lamont-Doherty Earth Observatory, Columbia University, New York City, NY, USA. ; Institute of Occupational Health, University of Brescia, Brescia, Italy. ; School of Health Sciences, Purdue University, West Lafayette, IN, USA. ; Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA. ; 1] Institute of Occupational Health, University of Brescia, Brescia, Italy [2] Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA [3] Icahn School of Medicine at Mount Sinai, New York City, NY, USA. PY - 2015 SP - 443 EP - 450 VL - 25 IS - 4 KW - Alloys KW - 0 KW - Dust KW - Soil KW - Soil Pollutants KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Environmental Monitoring KW - Humans KW - Seasons KW - Models, Statistical KW - Child KW - Adolescent KW - Italy KW - Manganese -- analysis KW - Dust -- analysis KW - Environmental Exposure -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Soil -- chemistry KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1690213007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Manganese+concentrations+in+soil+and+settled+dust+in+an+area+with+historic+ferroalloy+production.&rft.au=Pavilonis%2C+Brian+T%3BLioy%2C+Paul+J%3BGuazzetti%2C+Stefano%3BBostick%2C+Benjamin+C%3BDonna%2C+Filippo%3BPeli%2C+Marco%3BZimmerman%2C+Neil+J%3BBertrand%2C+Patrick%3BLucas%2C+Erika%3BSmith%2C+Donald+R%3BGeorgopoulos%2C+Panos+G%3BMi%2C+Zhongyuan%3BRoyce%2C+Steven+G%3BLucchini%2C+Roberto+G&rft.aulast=Pavilonis&rft.aufirst=Brian&rft.date=2015-07-01&rft.volume=25&rft.issue=4&rft.spage=443&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2014.70 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-15 N1 - Date created - 2015-06-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Arch Neurol. 2000 Apr;57(4):597-9 [10768639] Sci Total Environ. 2000 Jul 10;256(2-3):115-23 [10902839] J Expo Anal Environ Epidemiol. 2000 May-Jun;10(3):227-39 [10910116] Sci Total Environ. 2001 Feb 21;267(1-3):125-40 [11286208] Environ Sci Technol. 2002 Jun 1;36(11):2484-90 [12075809] Environ Res. 2003 Nov;93(3):301-7 [14615241] Pediatrics. 2004 Apr;113(4 Suppl):996-1006 [15060192] Ann N Y Acad Sci. 2004 Mar;1012:209-23 [15105268] Br J Ind Med. 1989 Dec;46(12):856-9 [2611159] Br J Ind Med. 1992 Jan;49(1):25-34 [1733453] Risk Anal. 1992 Jun;12(2):287-99 [1502376] Environ Res. 1994 Feb;64(2):151-80 [8306949] Neurology. 1994 Sep;44(9):1583-6 [7936278] J Toxicol Clin Toxicol. 1999;37(2):293-307 [10382563] Neurotoxicology. 1999 Apr-Jun;20(2-3):145-50 [10385878] Mol Aspects Med. 2005 Aug-Oct;26(4-5):353-62 [16099026] Environ Sci Technol. 2005 Oct 1;39(19):7410-5 [16245809] Neurotoxicology. 2006 Mar;27(2):210-6 [16310252] Neurotoxicology. 2006 May;27(3):347-9 [16337002] Sci Total Environ. 2006 May 15;361(1-3):67-72 [15972228] Environ Pollut. 2006 Sep;143(1):16-23 [16406626] Am J Ind Med. 2007 Nov;50(11):788-800 [17918215] Neurotoxicology. 2009 Nov;30(6):1207-13 [19393689] Neuromolecular Med. 2009;11(4):311-21 [20012385] Regul Toxicol Pharmacol. 2010 Jul-Aug;57(2-3):195-9 [20176068] Environ Res. 2011 Jan;111(1):156-63 [20943219] J Trace Elem Med Biol. 2012 Jun;26(2-3):179-82 [22664337] Neurotoxicology. 2012 Aug;33(4):697-702 [22285144] Neurotoxicology. 2012 Aug;33(4):687-96 [22322213] Environ Sci Pollut Res Int. 2013 Jul;20(7):5067-75 [23338992] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jes.2014.70 ER - TY - JOUR T1 - Silver nanoparticles: correlating nanoparticle size and cellular uptake with genotoxicity. AN - 1689843159; 25964273 AB - The focus of this research was to develop a better understanding of the pertinent physico-chemical properties of silver nanoparticles (AgNPs) that affect genotoxicity, specifically how cellular uptake influences a genotoxic cell response. The genotoxicity of AgNPs was assessed for three potential mechanisms: mutagenicity, clastogenicity and DNA strand-break-based DNA damage. Mutagenicity (reverse mutation assay) was assessed in five bacterial strains of Salmonella typhimurium and Echerichia coli, including TA102 that is sensitive to oxidative DNA damage. AgNPs of all sizes tested (10, 20, 50 and 100nm), along with silver nitrate (AgNO3), were negative for mutagenicity in bacteria. No AgNPs could be identified within the bacteria cells using transmission electron microscopy (TEM), indicating these bacteria lack the ability to actively uptake AgNPs 10nm or larger. Clastogenicity (flow cytometry-based micronucleus assay) and intermediate DNA damage (DNA strand breaks as measured in the Comet assay) were assessed in two mammalian white blood cell lines: Jurkat Clone E6-1 and THP-1. It was observed that micronucleus and Comet assay end points were inversely correlated with AgNP size, with smaller NPs inducing a more genotoxic response. TEM results indicated that AgNPs were confined within intracellular vesicles of mammalian cells and did not penetrate the nucleus. The genotoxicity test results and the effect of AgNO3 controls suggest that silver ions may be the primary, and perhaps only, cause of genotoxicity. Furthermore, since AgNO3 was not mutagenic in the gram-negative bacterial Ames strains tested, the lack of bacterial uptake of the AgNPs may not be the major reason for the lack of genotoxicity observed. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society 2015. JF - Mutagenesis AU - Butler, Kimberly S AU - Peeler, David J AU - Casey, Brendan J AU - Dair, Benita J AU - Elespuru, Rosalie K AD - U.S. Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry, and Materials Science, 10933 New Hampshire Avenue, Silver Spring, MD 20993, USA. ; U.S. Food and Drug Administration, Office of Medical Products and Tobacco, Center for Devices and Radiological Health, Office of Science and Engineering Laboratories, Division of Biology, Chemistry, and Materials Science, 10933 New Hampshire Avenue, Silver Spring, MD 20993, USA Rosalie.Elespuru@fda.hhs.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 577 EP - 591 VL - 30 IS - 4 KW - Anti-Bacterial Agents KW - 0 KW - Mutagens KW - Silver KW - 3M4G523W1G KW - Index Medicus KW - Comet Assay KW - Micronucleus Tests -- methods KW - Cell Survival -- genetics KW - Mutagenicity Tests -- methods KW - Escherichia coli Infections -- drug therapy KW - Humans KW - Jurkat Cells KW - DNA Repair -- drug effects KW - Microscopy, Electron, Transmission KW - Escherichia coli Infections -- microbiology KW - Cell Survival -- drug effects KW - Monocytes -- cytology KW - Cells, Cultured KW - Escherichia coli Infections -- genetics KW - Monocytes -- metabolism KW - Monocytes -- drug effects KW - Metal Nanoparticles -- administration & dosage KW - Salmonella typhimurium -- metabolism KW - Escherichia coli -- metabolism KW - Metal Nanoparticles -- chemistry KW - Anti-Bacterial Agents -- pharmacology KW - Escherichia coli -- genetics KW - Salmonella typhimurium -- drug effects KW - Mutagens -- pharmacology KW - DNA Damage -- genetics KW - DNA Damage -- drug effects KW - Silver -- chemistry KW - Escherichia coli -- drug effects KW - Salmonella typhimurium -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689843159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Silver+nanoparticles%3A+correlating+nanoparticle+size+and+cellular+uptake+with+genotoxicity.&rft.au=Butler%2C+Kimberly+S%3BPeeler%2C+David+J%3BCasey%2C+Brendan+J%3BDair%2C+Benita+J%3BElespuru%2C+Rosalie+K&rft.aulast=Butler&rft.aufirst=Kimberly&rft.date=2015-07-01&rft.volume=30&rft.issue=4&rft.spage=577&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgev020 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-08 N1 - Date created - 2015-06-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Water Res. 2008 Jan;42(1-2):356-62 [17692890] Microbios. 2001;104(409):141-8 [11327108] J Biomed Mater Res. 2000 Dec 15;52(4):662-8 [11033548] Mutat Res Genet Toxicol Environ Mutagen. 2014 Jul 1;768:14-22 [24769488] Antimicrob Agents Chemother. 2002 Aug;46(8):2668-70 [12121953] Int J Antimicrob Agents. 2004 Mar;23 Suppl 1:S75-8 [15037331] Can J Microbiol. 1974 Jun;20(6):883-9 [4151872] Mutat Res. 1983 May;113(3-4):173-215 [6341825] Biometals. 1994 Jan;7(1):30-40 [8118170] Biochemistry. 1995 Jun 20;34(24):7896-903 [7794901] Ann Occup Hyg. 2005 Oct;49(7):575-85 [15964881] J Hosp Infect. 2006 Jan;62(1):58-63 [16099072] Toxicol Appl Pharmacol. 2008 Dec 15;233(3):404-10 [18930072] Mutat Res. 2009 Mar-Jun;681(2-3):241-58 [19041420] ACS Nano. 2009 Feb 24;3(2):279-90 [19236062] Toxicol Sci. 2009 Apr;108(2):452-61 [19033393] J Antimicrob Chemother. 2010 Feb;65(2):258-65 [19942617] Environ Sci Technol. 2010 Jul 15;44(14):5649-54 [20583805] Part Fibre Toxicol. 2010;7:20 [20691052] Nanotoxicology. 2010 Dec;4:409-13 [20925448] Nanotoxicology. 2010 Dec;4:414-20 [20925449] Antimicrob Agents Chemother. 2010 Dec;54(12):5120-31 [20855737] J Nanosci Nanotechnol. 2010 Dec;10(12):8456-62 [21121354] Biomaterials. 2011 Feb;32(5):1264-9 [21093906] Arch Toxicol. 2011 Jul;85(7):743-50 [20428844] Acta Biomater. 2011 Sep;7(9):3505-14 [21651999] Biomaterials. 2011 Dec;32(36):9810-7 [21944826] Mutat Res. 2011 Dec 24;726(2):129-35 [21945414] Toxicol Lett. 2012 Feb 5;208(3):286-92 [22101214] Toxicol Appl Pharmacol. 2012 Jan 1;258(1):89-98 [22036727] Environ Sci Technol. 2012 Jan 17;46(2):752-9 [22142034] Environ Sci Technol. 2012 Jan 17;46(2):1119-27 [22148238] Mutat Res. 2012 Feb 18;742(1-2):61-5 [22178963] Mutat Res. 2012 Jun 14;745(1-2):104-11 [21971291] Mutat Res. 2012 Jun 14;745(1-2):4-10 [22138422] Environ Mol Mutagen. 2012 Jul;53(6):409-19 [22576574] Nano Lett. 2012 Aug 8;12(8):4271-5 [22765771] Appl Environ Microbiol. 2007 Mar;73(6):1712-20 [17261510] Neurol Res. 2008 Apr;30(3):285-7 [17767809] Environ Sci Technol. 2008 Jun 15;42(12):4583-8 [18605590] J Phys Chem B. 2008 Oct 30;112(43):13608-19 [18831567] ACS Nano. 2012 Aug 28;6(8):7427-42 [22857815] Nanotechnology. 2012 Sep 21;23(37):375102 [22922335] Mutat Res. 2012 Dec 12;749(1-2):60-9 [22960309] J Appl Toxicol. 2013 Feb;33(2):78-89 [22936301] Toxicol Lett. 2013 Sep 12;222(1):55-63 [23872614] Crit Rev Microbiol. 2013 Nov;39(4):373-83 [22928774] Toxicology. 2013 Nov 8;313(1):38-48 [23142790] Adv Colloid Interface Sci. 2014 Feb;204:15-34 [24406050] Yonsei Med J. 2014 Mar;55(2):283-91 [24532494] Part Fibre Toxicol. 2014;11:11 [24529161] J Appl Toxicol. 2014 Nov;34(11):1155-66 [24522958] J Antimicrob Chemother. 2008 Apr;61(4):869-76 [18305203] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/gev020 ER - TY - JOUR T1 - The Effect of Cerium Oxide Nanoparticle Valence State on Reactive Oxygen Species and Toxicity. AN - 1689621827; 25778836 AB - Cerium oxide (CeO2) nanoparticles, which are used in a variety of products including solar cells, gas sensors, and catalysts, are expected to increase in industrial use. This will subsequently lead to additional occupational exposures, making toxicology screenings crucial. Previous toxicology studies have presented conflicting results as to the extent of CeO2 toxicity, which is hypothesized to be due to the ability of Ce to exist in both a +3 and +4 valence state. Thus, to study whether valence state and oxygen vacancy concentration are important in CeO2 toxicity, CeO2 nanoparticles were doped with gadolinium to adjust the cation (Ce, Gd) and anion (O) defect states. The hypothesis that doping would increase toxicity and decrease antioxidant abilities as a result of increased oxygen vacancies and inhibition of +3 to +4 transition was tested. Differences in toxicity and reactivity based on valence state were determined in RLE-6TN rat alveolar epithelial and NR8383 rat alveolar macrophage cells using enhanced dark field microscopy, electron paramagnetic resonance (EPR), and annexin V/propidium iodide cell viability stain. Results from EPR indicated that as doping increased, antioxidant potential decreased. Alternatively, doping had no effect on toxicity at 24 h. The present results imply that as doping increases, thus subsequently increasing the Ce(3+)/Ce(4+) ratio, antioxidant potential decreases, suggesting that differences in reactivity of CeO2 are due to the ability of Ce to transition between the two valence states and the presence of increased oxygen vacancies, rather than dependent on a specific valence state. JF - Biological trace element research AU - Dunnick, Katherine M AU - Pillai, Rajalekshmi AU - Pisane, Kelly L AU - Stefaniak, Aleksandr B AU - Sabolsky, Edward M AU - Leonard, Stephen S AD - National Institute for Occupational Safety and Health, HELD, 1095 Willowdale Rd, Morgantown, WV, 26505, USA, kdunnick@mix.wvu.edu. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 96 EP - 107 VL - 166 IS - 1 KW - Antioxidants KW - 0 KW - Environmental Pollutants KW - Reactive Oxygen Species KW - Cerium KW - 30K4522N6T KW - gadolinium oxide KW - 5480D0NHLJ KW - ceric oxide KW - 619G5K328Y KW - Gadolinium KW - AU0V1LM3JT KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Animals KW - Cell Culture Techniques KW - Gadolinium -- chemistry KW - Macrophages, Alveolar -- drug effects KW - Structure-Activity Relationship KW - Epithelial Cells -- metabolism KW - Macrophages, Alveolar -- metabolism KW - Rats KW - Antioxidants -- metabolism KW - Epithelial Cells -- drug effects KW - Oxygen -- chemistry KW - Cell Line KW - Surface Properties KW - Reactive Oxygen Species -- metabolism KW - Environmental Pollutants -- toxicity KW - Environmental Pollutants -- chemistry KW - Cerium -- chemistry KW - Cerium -- toxicity KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689621827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+trace+element+research&rft.atitle=The+Effect+of+Cerium+Oxide+Nanoparticle+Valence+State+on+Reactive+Oxygen+Species+and+Toxicity.&rft.au=Dunnick%2C+Katherine+M%3BPillai%2C+Rajalekshmi%3BPisane%2C+Kelly+L%3BStefaniak%2C+Aleksandr+B%3BSabolsky%2C+Edward+M%3BLeonard%2C+Stephen+S&rft.aulast=Dunnick&rft.aufirst=Katherine&rft.date=2015-07-01&rft.volume=166&rft.issue=1&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Biological+trace+element+research&rft.issn=1559-0720&rft_id=info:doi/10.1007%2Fs12011-015-0297-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-17 N1 - Date created - 2015-06-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Toxicol Environ Health A. 2014;77(20):1251-68 [25208664] J Immunol. 2002 Oct 15;169(8):4531-41 [12370390] Biomaterials. 2007 Apr;28(10):1918-25 [17222903] Chem Commun (Camb). 2007 Mar 14;(10):1056-8 [17325804] Toxicology. 2008 Mar 12;245(1-2):90-100 [18243471] ACS Nano. 2008 Oct 28;2(10):2121-34 [19206459] Toxicol Lett. 2009 Jun 1;187(2):77-83 [19429248] Nanomedicine. 2010 Oct;6(5):698-705 [20172051] Part Fibre Toxicol. 2010;7:32 [21047424] Part Fibre Toxicol. 2011;8(1):2 [21247485] Crit Rev Toxicol. 2011 Mar;41(3):213-29 [21244219] ACS Nano. 2011 Jun 28;5(6):4537-49 [21612305] Toxicol Lett. 2011 Aug 28;205(2):105-15 [21624445] Toxicol Appl Pharmacol. 2012 Aug 1;262(3):255-64 [22613087] Toxicol In Vitro. 2013 Apr;27(3):1082-8 [23416263] Nanotoxicology. 2013 Dec;7(8):1338-50 [23061914] Cardiovasc Toxicol. 2013 Dec;13(4):323-37 [23645470] Environ Health Perspect. 1996 Mar;104 Suppl 1:85-95 [8722113] Int J Toxicol. 2006 Nov-Dec;25(6):451-7 [17132603] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s12011-015-0297-4 ER - TY - JOUR T1 - Advancing research on endocrine disrupting chemicals in breast cancer: Expert panel recommendations. AN - 1687361575; 25549947 AB - Breast cancer incidence continues to increase in the US and Europe, a reflection of the growing influence of environment factors that interact with personal genetics. The US Environmental Protection Agency estimates that there are approximately 10,000 endocrine disrupting chemicals among the common daily exposures that could affect the risk of disease. The daunting tasks of identifying, characterizing, and elucidating the mechanisms of endocrine disrupting chemicals in breast cancer need to be addressed to produce a comprehensive model that will facilitate preventive strategies and public policy. An expert panel met to describe and bring attention to needs linking common environmental exposures, critical windows of exposure, and optimal times of assessment in investigating breast cancer risk. The group included investigators with extensive experience in the use of rodent models and in leading population studies and produced a set of recommendations for effective approaches to gaining insights into the environmental origins of breast cancer across the lifespan. Published by Elsevier Inc. JF - Reproductive toxicology (Elmsford, N.Y.) AU - Teitelbaum, Susan L AU - Belpoggi, Fiorella AU - Reinlib, Les AD - Department of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ; Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bentivoglio, Bologna, Italy. ; National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, USA. Electronic address: reinlib@niehs.nih.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 141 EP - 147 VL - 54 KW - Carcinogens, Environmental KW - 0 KW - Endocrine Disruptors KW - Index Medicus KW - Endocrine disrupting chemicals KW - Windows of susceptibility KW - Mammary gland biology KW - Breast cancer KW - Sexual Development KW - Animals KW - Age Factors KW - Cell Transformation, Neoplastic -- pathology KW - Disease Susceptibility KW - Risk Factors KW - Humans KW - Cell Transformation, Neoplastic -- metabolism KW - Cell Transformation, Neoplastic -- chemically induced KW - Environmental Exposure -- adverse effects KW - Time Factors KW - Female KW - Risk Assessment KW - Mammary Glands, Animal -- drug effects KW - Mammary Glands, Human -- metabolism KW - Breast Neoplasms -- metabolism KW - Mammary Glands, Animal -- growth & development KW - Carcinogens, Environmental -- toxicity KW - Research Design KW - Endocrine Disruptors -- toxicity KW - Breast Neoplasms -- pathology KW - Biomedical Research -- methods KW - Mammary Glands, Animal -- metabolism KW - Mammary Glands, Animal -- pathology KW - Mammary Glands, Human -- pathology KW - Mammary Glands, Human -- growth & development KW - Breast Neoplasms -- chemically induced KW - Mammary Glands, Human -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687361575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.atitle=Advancing+research+on+endocrine+disrupting+chemicals+in+breast+cancer%3A+Expert+panel+recommendations.&rft.au=Teitelbaum%2C+Susan+L%3BBelpoggi%2C+Fiorella%3BReinlib%2C+Les&rft.aulast=Teitelbaum&rft.aufirst=Susan&rft.date=2015-07-01&rft.volume=54&rft.issue=&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Reproductive+toxicology+%28Elmsford%2C+N.Y.%29&rft.issn=1873-1708&rft_id=info:doi/10.1016%2Fj.reprotox.2014.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-04 N1 - Date created - 2015-06-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Hum Reprod. 2014 Jul;29(7):1558-66 [24781428] Environ Health Perspect. 2013 Sep;121(9):1040-6 [23876597] Int J Circumpolar Health. 2014;73:25760 [25442219] Reprod Toxicol. 2015 Jul;54:129-35 [25463529] J Epidemiol Biostat. 1999;4(3):191-210; discussion 210-5 [10695959] Environ Health Perspect. 2000 Jun;108 Suppl 3:451-5 [10852844] Environ Health Perspect. 2000 Jun;108 Suppl 3:573-94 [10852857] J Natl Cancer Inst. 2001 Jan 3;93(1):60-2 [11136844] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1509-14 [16896041] BMC Genomics. 2007;8:453 [18062813] J Toxicol Environ Health B Crit Rev. 2008 Mar;11(3-4):276-300 [18368557] Br J Cancer. 2008 May 6;98(9):1485-93 [18392054] Curr Stem Cell Res Ther. 2009 Jan;4(1):50-60 [19149630] Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2447-52 [19690178] Environ Health Perspect. 2010 Apr;118(4):539-44 [20368132] Environ Health Perspect. 2010 May;118(5):596-601 [20435547] Cancer Causes Control. 2010 Jul;21(7):999-1007 [20204493] Nat Rev Endocrinol. 2010 Jul;6(7):363-70 [20498677] Environ Health. 2011;10(1):5 [21241498] Environ Health Perspect. 2010 Nov;118(11):1614-9 [20675265] Toxicol Appl Pharmacol. 2011 Jul 15;254(2):181-91 [21034758] Toxicol Sci. 2011 Jul;122(1):134-45 [21482639] Br J Cancer. 2011 Aug 23;105(5):709-22 [21772329] Nat Med. 2011 Sep;17(9):1109-15 [21822285] J Steroid Biochem Mol Biol. 2011 Oct;127(1-2):16-26 [21397692] Chemosphere. 2011 Dec;85(11):1701-6 [22014662] Environ Health Perspect. 2011 Dec;119(12):1700-5 [21810551] Endocrinology. 2012 Jan;153(1):42-55 [22109888] FASEB J. 2012 Feb;26(2):778-87 [22049059] Eur J Epidemiol. 2012 Jan;27(1):1-3 [22286719] Int J Androl. 2012 Jun;35(3):216-26 [22428786] Reprod Toxicol. 2012 Jul;33(4):563-76 [22414604] Int J Mol Sci. 2012;13(8):10143-53 [22949852] Environ Health Perspect. 2012 Oct;120(10):1432-7 [22935244] Environ Health Perspect. 2012 Nov;120(11):1613-8 [23124194] J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):25-42 [23392570] J Adolesc Health. 2013 May;52(5 Suppl):S15-20 [23601607] ILAR J. 2012;53(3-4):289-305 [23744968] Breast J. 2001 Sep-Oct;7(5):278-91 [11906437] Environ Health Perspect. 2002 Jul;110(7):625-8 [12117637] Nature. 2003 May 29;423(6939):545-50 [12774124] Radiat Res. 2003 Dec;160(6):707-17 [14640793] Trends Endocrinol Metab. 2004 Jul;15(5):193-7 [15223047] Lancet. 1989 Sep 9;2(8663):577-80 [2570282] IARC Sci Publ. 1991;(112):3-23 [1855946] J Endocrinol. 1997 Mar;152(3):477-87 [9071969] J Anat. 1953 Oct;87(4):387-406 [13117757] J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):199-208 [23702822] Toxicol Sci. 2014 Jan;137(1):1-2 [24213143] Sci Rep. 2014;4:5664 [25012808] Climacteric. 2014 Aug;17(4):377-84 [24228746] J Expo Sci Environ Epidemiol. 2013 Jul;23(4):343-9 [22781437] Nutrition. 2005 Jun;21(6):775-7 [15925305] Birth Defects Res C Embryo Today. 2013 Jun;99(2):134-46 [23897597] J Clin Endocrinol Metab. 2014 Oct;99(10):3829-35 [25029416] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.reprotox.2014.12.015 ER - TY - JOUR T1 - Demographic characteristics and food choices of participants in the special diabetes program for American Indians diabetes prevention demonstration project AN - 1686418503; 4677187 AB - Objective. American Indians and Alaska Natives (AI/ANs) suffer a disproportionate burden of diabetes. Identifying food choices of AI/ANs at risk of type 2 diabetes, living in both rural and urban settings, is critical to the development of culturally relevant, evidence-based education strategies designed to reduce morbidity and mortality in this population. Reprinted by permission of Taylor & Francis Ltd. JF - Ethnicity and health AU - Teufel-Shone, Nicolette I AU - Jiang, Luohua AU - Beals, Janette AU - Henderson, William G AU - Zhang, Lijing AU - Acton, Kelly J AU - Roubideaux, Yvette AU - Manson, Spero M AD - University of Arizona ; Texas A&M University ; University of Colorado, Denver ; Indian Health Service Y1 - 2015/07// PY - 2015 DA - Jul 2015 SP - 327 EP - 340 VL - 20 IS - 4 SN - 1355-7858, 1355-7858 KW - Sociology KW - Cultural development KW - Risk KW - Mortality KW - Education KW - U.S.A. KW - Morbidity KW - Diabetes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686418503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+and+health&rft.atitle=Demographic+characteristics+and+food+choices+of+participants+in+the+special+diabetes+program+for+American+Indians+diabetes+prevention+demonstration+project&rft.au=Teufel-Shone%2C+Nicolette+I%3BJiang%2C+Luohua%3BBeals%2C+Janette%3BHenderson%2C+William+G%3BZhang%2C+Lijing%3BActon%2C+Kelly+J%3BRoubideaux%2C+Yvette%3BManson%2C+Spero+M&rft.aulast=Teufel-Shone&rft.aufirst=Nicolette&rft.date=2015-07-01&rft.volume=20&rft.issue=4&rft.spage=327&rft.isbn=&rft.btitle=&rft.title=Ethnicity+and+health&rft.issn=13557858&rft_id=info:doi/10.1080%2F13557858.2014.921890 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-06-08 N1 - Last updated - 2015-06-08 N1 - SubjectsTermNotLitGenreText - 3524 6220; 4049; 8291 3409 6306; 3119 3105 3198 3483; 11035; 8285 3409 6306; 433 293 14 DO - http://dx.doi.org/10.1080/13557858.2014.921890 ER - TY - JOUR T1 - Dynamic Response of Mycobacterium vanbaalenii PYR-1 to BP Deepwater Horizon Crude Oil. AN - 1686415677; 25888169 AB - We investigated the response of the hydrocarbon-degrading Mycobacterium vanbaalenii PYR-1 to crude oil from the BP Deepwater Horizon (DWH) spill, using substrate depletion, genomic, and proteome analyses. M. vanbaalenii PYR-1 cultures were incubated with BP DWH crude oil, and proteomes and degradation of alkanes and polycyclic aromatic hydrocarbons (PAHs) were analyzed at four time points over 30 days. Gas chromatography-mass spectrometry (GC-MS) analysis showed a chain length-dependent pattern of alkane degradation, with C12 and C13 being degraded at the highest rate, although alkanes up to C28 were degraded. Whereas phenanthrene and pyrene were completely degraded, a significantly smaller amount of fluoranthene was degraded. Proteome analysis identified 3,948 proteins, with 876 and 1,859 proteins up- and downregulated, respectively. We observed dynamic changes in protein expression during BP crude oil incubation, including transcriptional factors and transporters potentially involved in adaptation to crude oil. The proteome also provided a molecular basis for the metabolism of the aliphatic and aromatic hydrocarbon components in the BP DWH crude oil, which included upregulation of AlkB alkane hydroxylase and an expression pattern of PAH-metabolizing enzymes different from those in previous proteome expression studies of strain PYR-1 incubated with pure or mixed PAHs, particularly the ring-hydroxylating oxygenase (RHO) responsible for the initial oxidation of aromatic hydrocarbons. Based on these results, a comprehensive cellular response of M. vanbaalenii PYR-1 to BP crude oil was proposed. This study increases our fundamental understanding of the impact of crude oil on the cellular response of bacteria and provides data needed for development of practical bioremediation applications. Copyright © 2015, American Society for Microbiology. All Rights Reserved. JF - Applied and environmental microbiology AU - Kim, Seong-Jae AU - Kweon, Ohgew AU - Sutherland, John B AU - Kim, Hyun-Lee AU - Jones, Richard C AU - Burback, Brian L AU - Graves, Steven W AU - Psurny, Edward AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, Arkansas, USA. ; MS Bioworks, LLC, Ann Arbor, Michigan, USA. ; Life Sciences Research, Battelle Memorial Institute, Columbus, Ohio, USA. ; Division of Microbiology, National Center for Toxicological Research/U.S. Food and Drug Administration, Jefferson, Arkansas, USA carl.cerniglia@fda.hhs.gov. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 4263 EP - 4276 VL - 81 IS - 13 KW - Alkenes KW - 0 KW - Bacterial Proteins KW - Petroleum KW - Polycyclic Aromatic Hydrocarbons KW - Proteome KW - Index Medicus KW - Gene Expression Profiling KW - Petroleum Pollution KW - Gas Chromatography-Mass Spectrometry KW - Proteome -- analysis KW - Petroleum -- metabolism KW - Mycobacterium -- genetics KW - Bacterial Proteins -- biosynthesis KW - Mycobacterium -- drug effects KW - Mycobacterium -- metabolism KW - Alkenes -- metabolism KW - Gene Expression Regulation, Bacterial -- drug effects KW - Polycyclic Aromatic Hydrocarbons -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686415677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Dynamic+Response+of+Mycobacterium+vanbaalenii+PYR-1+to+BP+Deepwater+Horizon+Crude+Oil.&rft.au=Kim%2C+Seong-Jae%3BKweon%2C+Ohgew%3BSutherland%2C+John+B%3BKim%2C+Hyun-Lee%3BJones%2C+Richard+C%3BBurback%2C+Brian+L%3BGraves%2C+Steven+W%3BPsurny%2C+Edward%3BCerniglia%2C+Carl+E&rft.aulast=Kim&rft.aufirst=Seong-Jae&rft.date=2015-07-01&rft.volume=81&rft.issue=13&rft.spage=4263&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.00730-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-25 N1 - Date created - 2015-06-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Pathol. 2012;40(2):315-20 [22105647] Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14321-6 [14623960] Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11234-9 [22733752] ISME J. 2012 Sep;6(9):1715-27 [22717885] ISME J. 2013 Nov;7(11):2091-104 [23788333] Braz J Microbiol. 2013;44(2):633-41 [24294263] Microbiol Mol Biol Rev. 2003 Dec;67(4):503-49 [14665675] Appl Environ Microbiol. 2004 Jan;70(1):340-5 [14711661] Microbiol Rev. 1981 Mar;45(1):180-209 [7012571] Appl Environ Microbiol. 1988 Jun;54(6):1612-4 [3415226] Appl Environ Microbiol. 1988 Oct;54(10):2549-55 [3202633] Appl Environ Microbiol. 1989 Aug;55(8):1968-73 [2782874] Microbiol Rev. 1990 Sep;54(3):305-15 [2215423] Arch Microbiol. 1991;156(3):223-30 [1953305] Biodegradation. 1990;1(4):283-90 [1368473] Proteomics. 2004 Dec;4(12):3899-908 [15540208] Biodegradation. 2005 Dec;16(6):513-26 [15865344] Microb Ecol. 2005 Jul;50(1):110-9 [16132428] Appl Environ Microbiol. 2006 Feb;72(2):1045-54 [16461648] BMC Bioinformatics. 2006;7:191 [16597342] Appl Microbiol Biotechnol. 2006 Jul;71(4):522-32 [16317545] J Bacteriol. 2007 Jan;189(2):464-72 [17085566] Appl Microbiol Biotechnol. 2007 Feb;74(1):13-21 [17216462] Curr Opin Biotechnol. 2007 Jun;18(3):257-66 [17493798] J Bacteriol. 2007 Jul;189(13):4635-47 [17449607] BMC Biochem. 2008;9:11 [18387195] Biodegradation. 2008 Nov;19(6):859-81 [18421421] Biotechnol Adv. 2008 Nov-Dec;26(6):561-75 [18725284] Curr Opin Biotechnol. 2008 Dec;19(6):579-89 [19000761] Appl Environ Microbiol. 2009 Oct;75(19):6232-9 [19666730] Environ Microbiol. 2009 Oct;11(10):2477-90 [19807712] J Bacteriol. 2009 Dec;191(23):7260-9 [19767422] MBio. 2010;1(2). pii: e00135-10. doi: 10.1128/mBio.00135-10 [20714442] Science. 2010 Oct 8;330(6001):204-8 [20736401] Environ Microbiol. 2010 Dec;12(12):3089-104 [20860734] J Bacteriol. 2011 Sep;193(17):4326-37 [21725022] Microb Ecol. 2011 Nov;62(4):959-72 [21567188] Appl Environ Microbiol. 2011 Nov;77(22):7962-74 [21948834] ISME J. 2012 Feb;6(2):451-60 [21814288] J Bacteriol. 2014 Oct;196(19):3503-15 [25070740] Ann Rev Mar Sci. 2015;7:377-401 [25251273] Mol Cell Proteomics. 2014 Nov;13(11):3014-28 [24997995] Nucleic Acids Res. 2000 Jan 1;28(1):33-6 [10592175] Appl Environ Microbiol. 2001 Apr;67(4):1476-83 [11282593] Appl Environ Microbiol. 2001 Aug;67(8):3577-85 [11472934] Appl Microbiol Biotechnol. 2002 Mar;58(3):364-9 [11935189] Appl Environ Microbiol. 2002 Dec;68(12):5933-42 [12450813] J Appl Microbiol. 2003;94(2):230-9 [12534814] J Biol Chem. 2003 Jan 17;278(3):1735-43 [12393860] Int J Syst Evol Microbiol. 2002 Nov;52(Pt 6):1997-2002 [12508859] Appl Environ Microbiol. 2003 Jul;69(7):3924-31 [12839762] J Exp Med. 2003 Sep 1;198(5):693-704 [12953091] Appl Microbiol Biotechnol. 2003 Sep;62(4):380-6 [12719937] Appl Environ Microbiol. 2012 May;78(10):3715-23 [22407691] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/AEM.00730-15 ER - TY - JOUR T1 - Safety of octreotide in hospitalized infants. AN - 1684433252; 25968047 AB - Octreotide is used off-label in infants for treatment of chylothorax, congenital hyperinsulinism, and gastrointestinal bleeding. The safety profile of octreotide in hospitalized infants has not been described; we sought to fill this information gap. We identified all infants exposed to at least 1 dose of octreotide from a cohort of 887,855 infants discharged from 333 neonatal intensive care units managed by the Pediatrix Medical Group between 1997 and 2012. We collected laboratory and clinical information while infants were exposed to octreotide and described the frequency of baseline diagnoses, laboratory abnormalities, and clinical adverse events (AEs). A total of 428 infants received 490 courses of octreotide. The diagnoses most commonly associated with octreotide use were chylothorax (50%), pleural effusion (32%), and hypoglycemia (22%). The most common laboratory AEs that occurred during exposure to octreotide were thrombocytopenia (47/1000 infant-days), hyperkalemia (21/1000 infant-days), and leukocytosis (20/1000 infant-days). Hyperglycemia occurred in 1/1000 infant-days and hypoglycemia in 3/1000 infant-days. Hypotension requiring pressors (12%) was the most common clinical AE that occurred during exposure to octreotide. Necrotizing enterocolitis was observed in 9/490 (2%) courses, and death occurred in 11 (3%) infants during octreotide administration. Relatively few AEs occurred during off-label use of octreotide in this cohort of infants. Additional studies are needed to further evaluate the safety, dosing, and efficacy of this medication in infants. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved. JF - Early human development AU - Testoni, Daniela AU - Hornik, Christoph P AU - Neely, Megan L AU - Yang, Qinghong AU - McMahon, Ann W AU - Clark, Reese H AU - Smith, P Brian AU - Best Pharmaceuticals for Children Act — Pediatric Trials Network Administrative Core Committee AD - Duke Clinical Research Institute, Durham, NC, United States; Division of Neonatal Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil. ; Duke Clinical Research Institute, Durham, NC, United States; Department of Pediatrics, Duke University, Durham, NC, United States. ; Duke Clinical Research Institute, Durham, NC, United States; Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, United States. ; Duke Clinical Research Institute, Durham, NC, United States. ; Office of Pediatric Therapeutics, Food and Drug Administration, Silver Spring, MD, United States. ; Pediatrix-Obstetrix Center for Research and Education, Sunrise, FL, United States. ; Duke Clinical Research Institute, Durham, NC, United States; Department of Pediatrics, Duke University, Durham, NC, United States. Electronic address: brian.smith@duke.edu. ; Best Pharmaceuticals for Children Act — Pediatric Trials Network Administrative Core Committee Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 387 EP - 392 VL - 91 IS - 7 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Octreotide KW - RWM8CCW8GP KW - Index Medicus KW - Infant KW - Drug toxicity KW - Safety KW - Off-Label Use KW - Hospitalization KW - Humans KW - Infant, Newborn KW - Chylothorax -- drug therapy KW - Pleural Effusion -- drug therapy KW - Intensive Care Units, Neonatal KW - Hypoglycemia -- drug therapy KW - Male KW - Female KW - Hypotension -- chemically induced KW - Octreotide -- therapeutic use KW - Octreotide -- adverse effects KW - Thrombocytopenia -- chemically induced KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Antineoplastic Agents, Hormonal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684433252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Early+human+development&rft.atitle=Safety+of+octreotide+in+hospitalized+infants.&rft.au=Testoni%2C+Daniela%3BHornik%2C+Christoph+P%3BNeely%2C+Megan+L%3BYang%2C+Qinghong%3BMcMahon%2C+Ann+W%3BClark%2C+Reese+H%3BSmith%2C+P+Brian%3BBest+Pharmaceuticals+for+Children+Act+%E2%80%94+Pediatric+Trials+Network+Administrative+Core+Committee&rft.aulast=Testoni&rft.aufirst=Daniela&rft.date=2015-07-01&rft.volume=91&rft.issue=7&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Early+human+development&rft.issn=1872-6232&rft_id=info:doi/10.1016%2Fj.earlhumdev.2015.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-23 N1 - Date created - 2015-05-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Saudi J Gastroenterol. 2012 Mar-Apr;18(2):87-94 [22421712] Eur Respir J. 2012 Mar;39(3):772-5 [22379151] PLoS One. 2012;7(5):e36411 [22574156] J Pediatr Surg. 2013 Mar;48(3):568-72 [23480914] Gastroenterology. 2003 May;124(5):1277-91 [12730868] Pediatr Crit Care Med. 2006 May;7(3):245-8 [16575348] J Pediatr Surg. 2008 Jun;43(6):1209-10 [18558210] Pediatr Blood Cancer. 2008 Dec;51(6):824-5 [18726919] Eur J Cancer. 2009 Jul;45(10):1788-97 [19303768] Life Sci. 1982 Sep 13;31(11):1133-40 [6128648] J Clin Endocrinol Metab. 1985 Jun;60(6):1161-5 [2860119] Am J Surg. 1991 Jan;161(1):177-82; discussion 182-3 [1987853] Arch Dis Child. 1992 Apr;67(4 Spec No):432-5 [1586186] Gut. 1996 May;38(5):775-83 [8707128] Aliment Pharmacol Ther. 1998 Mar;12(3):237-45 [9570258] Pediatr Cardiol. 2005 Jul-Aug;26(4):440-3 [16374694] J Clin Oncol. 2009 Oct 1;27(28):4656-63 [19704057] Rev Port Cardiol. 2009 Jul-Aug;28(7-8):799-807 [19894659] Pediatr Nephrol. 2010 Feb;25(2):363-6 [19902268] Pediatr Diabetes. 2010 Mar;11(2):142-7 [19558634] Eur J Pediatr. 2000 Jul;159(7):550 [10923237] Ann Hematol. 2013 Jul;92(7):961-7 [23519382] J Pediatr Gastroenterol Nutr. 2004 Jan;38(1):41-7 [14676593] J Perinatol. 2004 Mar;24(3):194-5 [15044931] Pediatr Crit Care Med. 2004 Jul;5(4):356-7 [15215005] Acta Chir Scand. 1979;145(7):443-46 [161458] Arq Bras Endocrinol Metabol. 2005 Jun;49(3):460-7 [16544003] Intensive Care Med. 2006 May;32(5):650-7 [16532329] J Pediatr Gastroenterol Nutr. 2010 Oct;51(4):454-7 [20512058] Fed Regist. 2010 Sep 29;75(188):59935-63 [20879180] Congenit Heart Dis. 2010 Nov-Dec;5(6):573-8 [21106017] Pediatr Blood Cancer. 2011 Jan;56(1):45-9 [21108438] Adv Neonatal Care. 2011 Jun;11(3):155-64; quiz 165-6 [21730907] Arq Bras Cardiol. 2011 Aug;97(2):e33-6 [22002034] Pediatr Neonatol. 2011 Oct;52(5):297-301 [22036228] Eur J Endocrinol. 2012 Feb;166(2):333-9 [22048969] J Perinatol. 2012 Mar;32(3):199-204 [21593813] Br J Haematol. 2012 May;157(3):381-2 [22145577] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.earlhumdev.2015.04.008 ER - TY - JOUR T1 - Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats. AN - 1684432957; 25862956 AB - Bisphenol A (BPA), an industrial chemical used in the manufacture of polycarbonate and epoxy resins, binds to the nuclear estrogen receptor with an affinity 4-5 orders of magnitude lower than that of estradiol. We reported previously that "high BPA" [100,000 and 300,000 µg/kg body weight (bw)/day], but not "low BPA" (2.5-2700 µg/kg bw/day), induced clear adverse effects in NCTR Sprague-Dawley rats gavaged daily from gestation day 6 through postnatal day (PND) 90. The "high BPA" effects partially overlapped those of ethinyl estradiol (EE2, 0.5 and 5.0 µg/kg bw/day). To evaluate further the potential of "low BPA" to induce biological effects, here we assessed the global genomic DNA methylation and gene expression in the prostate and female mammary glands, tissues identified previously as potential targets of BPA, and uterus, a sensitive estrogen-responsive tissue. Both doses of EE2 modulated gene expression, including of known estrogen-responsive genes, and PND 4 global gene expression data showed a partial overlap of the "high BPA" effects with those of EE2. The "low BPA" doses modulated the expression of several genes; however, the absence of a dose response reduces the likelihood that these changes were causally linked to the treatment. These results are consistent with the toxicity outcomes. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Camacho, Luísa AU - Basavarajappa, Mallikarjuna S AU - Chang, Ching-Wei AU - Han, Tao AU - Kobets, Tetyana AU - Koturbash, Igor AU - Surratt, Gordon AU - Lewis, Sherry M AU - Vanlandingham, Michelle M AU - Fuscoe, James C AU - Gamboa da Costa, Gonçalo AU - Pogribny, Igor P AU - Delclos, K Barry AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: luisa.camacho@fda.hhs.gov. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Office of Scientific Coordination, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015/07// PY - 2015 DA - July 2015 SP - 92 EP - 103 VL - 81 KW - Benzhydryl Compounds KW - 0 KW - Complement C3 KW - Phenols KW - Receptors, Estrogen KW - Receptors, Progesterone KW - S100 Calcium Binding Protein G KW - Vascular Endothelial Growth Factor A KW - vascular endothelial growth factor A, rat KW - Ethinyl Estradiol KW - 423D2T571U KW - Methyltransferases KW - EC 2.1.1.- KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - Bisphenol A KW - Microarray KW - Ethinyl estradiol KW - Mammary gland KW - Prostate KW - Global genomic DNA methylation KW - Animals KW - Gene Expression KW - Ethinyl Estradiol -- toxicity KW - Rats KW - Receptors, Progesterone -- metabolism KW - Methyltransferases -- metabolism KW - Ethinyl Estradiol -- administration & dosage KW - Male KW - Administration, Oral KW - Genomics -- methods KW - Dose-Response Relationship, Drug KW - Complement C3 -- genetics KW - Tandem Mass Spectrometry KW - Receptors, Estrogen -- metabolism KW - Complement C3 -- metabolism KW - Protein Binding KW - Pregnancy KW - Prenatal Exposure Delayed Effects -- pathology KW - Receptors, Progesterone -- genetics KW - Rats, Sprague-Dawley KW - Receptors, Estrogen -- genetics KW - Chromatography, Liquid KW - S100 Calcium Binding Protein G -- genetics KW - S100 Calcium Binding Protein G -- metabolism KW - Vascular Endothelial Growth Factor A -- genetics KW - Female KW - Vascular Endothelial Growth Factor A -- metabolism KW - Uterus -- metabolism KW - Prostate -- drug effects KW - Phenols -- administration & dosage KW - Benzhydryl Compounds -- toxicity KW - Mammary Glands, Animal -- drug effects KW - Mammary Glands, Animal -- metabolism KW - DNA Methylation -- drug effects KW - Prostate -- metabolism KW - Phenols -- toxicity KW - Uterus -- drug effects KW - Benzhydryl Compounds -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684432957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Effects+of+oral+exposure+to+bisphenol+A+on+gene+expression+and+global+genomic+DNA+methylation+in+the+prostate%2C+female+mammary+gland%2C+and+uterus+of+NCTR+Sprague-Dawley+rats.&rft.au=Camacho%2C+Lu%C3%ADsa%3BBasavarajappa%2C+Mallikarjuna+S%3BChang%2C+Ching-Wei%3BHan%2C+Tao%3BKobets%2C+Tetyana%3BKoturbash%2C+Igor%3BSurratt%2C+Gordon%3BLewis%2C+Sherry+M%3BVanlandingham%2C+Michelle+M%3BFuscoe%2C+James+C%3BGamboa+da+Costa%2C+Gon%C3%A7alo%3BPogribny%2C+Igor+P%3BDelclos%2C+K+Barry&rft.aulast=Camacho&rft.aufirst=Lu%C3%ADsa&rft.date=2015-07-01&rft.volume=81&rft.issue=&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.04.009 LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.04.009 ER - TY - JOUR T1 - Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. AN - 1698962220; 26109056 AB - Gene expression profiling is being widely applied in cancer research to identify biomarkers for clinical endpoint prediction. Since RNA-seq provides a powerful tool for transcriptome-based applications beyond the limitations of microarrays, we sought to systematically evaluate the performance of RNA-seq-based and microarray-based classifiers in this MAQC-III/SEQC study for clinical endpoint prediction using neuroblastoma as a model. We generate gene expression profiles from 498 primary neuroblastomas using both RNA-seq and 44 k microarrays. Characterization of the neuroblastoma transcriptome by RNA-seq reveals that more than 48,000 genes and 200,000 transcripts are being expressed in this malignancy. We also find that RNA-seq provides much more detailed information on specific transcript expression patterns in clinico-genetic neuroblastoma subgroups than microarrays. To systematically compare the power of RNA-seq and microarray-based models in predicting clinical endpoints, we divide the cohort randomly into training and validation sets and develop 360 predictive models on six clinical endpoints of varying predictability. Evaluation of factors potentially affecting model performances reveals that prediction accuracies are most strongly influenced by the nature of the clinical endpoint, whereas technological platforms (RNA-seq vs. microarrays), RNA-seq data analysis pipelines, and feature levels (gene vs. transcript vs. exon-junction level) do not significantly affect performances of the models. We demonstrate that RNA-seq outperforms microarrays in determining the transcriptomic characteristics of cancer, while RNA-seq and microarray-based models perform similarly in clinical endpoint prediction. Our findings may be valuable to guide future studies on the development of gene expression-based predictive models and their implementation in clinical practice. JF - Genome biology AU - Zhang, Wenqian AU - Yu, Ying AU - Hertwig, Falk AU - Thierry-Mieg, Jean AU - Zhang, Wenwei AU - Thierry-Mieg, Danielle AU - Wang, Jian AU - Furlanello, Cesare AU - Devanarayan, Viswanath AU - Cheng, Jie AU - Deng, Youping AU - Hero, Barbara AU - Hong, Huixiao AU - Jia, Meiwen AU - Li, Li AU - Lin, Simon M AU - Nikolsky, Yuri AU - Oberthuer, André AU - Qing, Tao AU - Su, Zhenqiang AU - Volland, Ruth AU - Wang, Charles AU - Wang, May D AU - Ai, Junmei AU - Albanese, Davide AU - Asgharzadeh, Shahab AU - Avigad, Smadar AU - Bao, Wenjun AU - Bessarabova, Marina AU - Brilliant, Murray H AU - Brors, Benedikt AU - Chierici, Marco AU - Chu, Tzu-Ming AU - Zhang, Jibin AU - Grundy, Richard G AU - He, Min Max AU - Hebbring, Scott AU - Kaufman, Howard L AU - Lababidi, Samir AU - Lancashire, Lee J AU - Li, Yan AU - Lu, Xin X AU - Luo, Heng AU - Ma, Xiwen AU - Ning, Baitang AU - Noguera, Rosa AU - Peifer, Martin AU - Phan, John H AU - Roels, Frederik AU - Rosswog, Carolina AU - Shao, Susan AU - Shen, Jie AU - Theissen, Jessica AU - Tonini, Gian Paolo AU - Vandesompele, Jo AU - Wu, Po-Yen AU - Xiao, Wenzhong AU - Xu, Joshua AU - Xu, Weihong AU - Xuan, Jiekun AU - Yang, Yong AU - Ye, Zhan AU - Dong, Zirui AU - Zhang, Ke K AU - Yin, Ye AU - Zhao, Chen AU - Zheng, Yuanting AU - Wolfinger, Russell D AU - Shi, Tieliu AU - Malkas, Linda H AU - Berthold, Frank AU - Wang, Jun AU - Tong, Weida AU - Shi, Leming AU - Peng, Zhiyu AU - Fischer, Matthias AD - BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Yantian District, Shenzhen, Guangdong, 518083, China. ; Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, 201203, China. ; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Kerpener Strasse 62, D-50924, Cologne, Germany. ; NIH/NCBI, Bldg 38A/Room 8S808, 8600 Rockville Pike, Bethesda, MD, 20894, USA. ; Eli Lilly and Company Research Informatics, Lilly Corporate Center, Drop Code 0725, Indianapolis, IN, 46285, USA. ; Fondazione Bruno Kessler (FBK), Via Sommarive 18, 38123, Trento Povo, TN, Italy. ; AbbVie Inc., Global Pharmaceutical R&D, 32 Knights Crest Court, Souderton, PA, 18964, USA. ; GlaxoSmithKline, Discovery Analytics, Mailstop UP4335, 1250 South Collegeville Rd, Collegeville, PA, 19426, USA. ; Department of Internal Medicine, Rush University Cancer Center, 1725 W. Harrison Street, Chicago, IL, 60612, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. ; SAS Institute Inc., SAS Campus Drive, Cary, NC, 27513, USA. ; Marshfield Clinic Research Foundation, Biomedical Informatics Research Center, 1000 N Oak Avenue, Marshfield, WI, 54449, USA. ; Thomson Reuters IP & Science, 5901 Priesty Drive, Carlsbad, CA, 92008, USA. ; Center for Genomics and Division of Microbiology & Molecular Genetics, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA. ; Department of Biomedical Engineering, GeorgiaTech and Emory University, 313 Ferst Drive, Atlanta, GA, 30332, USA. ; Fondazione Edmund Mach, CRI-CBC, San Michele all'Adige, TN, Italy. ; Children's Hospital Los Angeles, Los Angeles, CA, 90027, USA. ; Department of Pediatric Hematology-Oncology, Molecular Oncology, Felsenstein Medical Research Center, Schneider Children's Medical Center of Israel, Petach Tikva, 49202, Israel. ; Marshfield Clinic Research Foundation, Center of Human Genetics, 1000 N Oak Avenue, Marshfield, WI, 54449, USA. ; Department of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany. ; University of Nottingham, Children's Brain Tumour Research Centre, Queen's Medical Centre, University of Nottingham, D Floor Medical School, Nottingham, NG7 2UH, UK. ; Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, WOC1 RM400S, HFM-210, 1401 Rockville Pike, Rockville, MD, 20852, USA. ; AbbVie Inc., Global Pharmaceutical Research and Development, 1 North Waukegan Road, North Chicago, IL, 60064, USA. ; Eli Lilly and Company, Discovery Statistics, Lilly Corporate Center, Drop Code 2036, Indianapolis, IN, 46285, USA. ; Department of Pathology, University of Valencia, Medical School, Avda. Blasco Ibáñez, 17, 46010, Valencia, Spain. ; University of Cologne, Center for Molecular Medicine (CMMC), Medical Faculty, Kerpener Strasse 62, D-50924, Cologne, Germany. ; Neuroblastoma Laboratory, Onco/Hematology Laboratory, SDB Department, University of Padua, Pediatric Research Institute, Padua, Italy. ; Department of Pediatrics and Genetics, Ghent University, Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000, Ghent, Belgium. ; Georgia Institute of Technology, School of Electrical and Computer Engineering, 777 Atlantic Drive NW, Atlanta, GA, 30332, USA. ; Harvard Medical School, Massachusetts General Hospital, 51 Blossom Street, Boston, MA, 02114, USA. ; Stanford University, Stanford Genome Technology Center, 855 South California Avenue, Palo Alto, CA, 94304, USA. ; Department of Pathology, University of North Dakota School of Medicine, 501 N. Columbia Road RM 3573, Grand Forks, ND, 58202-9037, USA. ; East China Normal University, Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, the Institute of Biomedical Sciences and School of Life Sciences, 500 Dongchuan Road, Shanghai, 200241, China. ; Department of Molecular & Cellular Biology, Beckman Research Institute, City of Hope Comprehensive Cancer Center, Duarte, CA, 91010, USA. ; Collaborative Innovation Center for Genetics and Development, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and School of Pharmacy, Fudan University, Shanghai, 201203, China. lemingshi@fudan.edu.cn. ; BGI-Shenzhen, Main Building, Bei Shan Industrial Zone, Yantian District, Shenzhen, Guangdong, 518083, China. pengzhiyu@genomics.org.cn. ; Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Kerpener Strasse 62, D-50924, Cologne, Germany. matthias.fischer@uk-koeln.de. Y1 - 2015/06/25/ PY - 2015 DA - 2015 Jun 25 SP - 133 VL - 16 KW - Index Medicus KW - Infant KW - Young Adult KW - Tumor Cells, Cultured KW - Endpoint Determination KW - Models, Genetic KW - Humans KW - Adult KW - Infant, Newborn KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Gene Expression Profiling KW - Neuroblastoma -- genetics KW - Neuroblastoma -- diagnosis KW - Oligonucleotide Array Sequence Analysis KW - Sequence Analysis, RNA KW - Neuroblastoma -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698962220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+biology&rft.atitle=Comparison+of+RNA-seq+and+microarray-based+models+for+clinical+endpoint+prediction.&rft.au=Zhang%2C+Wenqian%3BYu%2C+Ying%3BHertwig%2C+Falk%3BThierry-Mieg%2C+Jean%3BZhang%2C+Wenwei%3BThierry-Mieg%2C+Danielle%3BWang%2C+Jian%3BFurlanello%2C+Cesare%3BDevanarayan%2C+Viswanath%3BCheng%2C+Jie%3BDeng%2C+Youping%3BHero%2C+Barbara%3BHong%2C+Huixiao%3BJia%2C+Meiwen%3BLi%2C+Li%3BLin%2C+Simon+M%3BNikolsky%2C+Yuri%3BOberthuer%2C+Andr%C3%A9%3BQing%2C+Tao%3BSu%2C+Zhenqiang%3BVolland%2C+Ruth%3BWang%2C+Charles%3BWang%2C+May+D%3BAi%2C+Junmei%3BAlbanese%2C+Davide%3BAsgharzadeh%2C+Shahab%3BAvigad%2C+Smadar%3BBao%2C+Wenjun%3BBessarabova%2C+Marina%3BBrilliant%2C+Murray+H%3BBrors%2C+Benedikt%3BChierici%2C+Marco%3BChu%2C+Tzu-Ming%3BZhang%2C+Jibin%3BGrundy%2C+Richard+G%3BHe%2C+Min+Max%3BHebbring%2C+Scott%3BKaufman%2C+Howard+L%3BLababidi%2C+Samir%3BLancashire%2C+Lee+J%3BLi%2C+Yan%3BLu%2C+Xin+X%3BLuo%2C+Heng%3BMa%2C+Xiwen%3BNing%2C+Baitang%3BNoguera%2C+Rosa%3BPeifer%2C+Martin%3BPhan%2C+John+H%3BRoels%2C+Frederik%3BRosswog%2C+Carolina%3BShao%2C+Susan%3BShen%2C+Jie%3BTheissen%2C+Jessica%3BTonini%2C+Gian+Paolo%3BVandesompele%2C+Jo%3BWu%2C+Po-Yen%3BXiao%2C+Wenzhong%3BXu%2C+Joshua%3BXu%2C+Weihong%3BXuan%2C+Jiekun%3BYang%2C+Yong%3BYe%2C+Zhan%3BDong%2C+Zirui%3BZhang%2C+Ke+K%3BYin%2C+Ye%3BZhao%2C+Chen%3BZheng%2C+Yuanting%3BWolfinger%2C+Russell+D%3BShi%2C+Tieliu%3BMalkas%2C+Linda+H%3BBerthold%2C+Frank%3BWang%2C+Jun%3BTong%2C+Weida%3BShi%2C+Leming%3BPeng%2C+Zhiyu%3BFischer%2C+Matthias&rft.aulast=Zhang&rft.aufirst=Wenqian&rft.date=2015-06-25&rft.volume=16&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Genome+biology&rft.issn=1474-760X&rft_id=info:doi/10.1186%2Fs13059-015-0694-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-23 N1 - Date created - 2015-07-18 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Clin Oncol. 2010 Jul 20;28(21):3506-15 [20567016] Nat Biotechnol. 2010 May;28(5):511-5 [20436464] Nat Biotechnol. 2010 Aug;28(8):827-38 [20676074] Nat Rev Genet. 2011 Feb;12(2):87-98 [21191423] Nat Biotechnol. 2011 Aug;29(8):742-9 [21804560] Lancet. 2011 Nov 19;378(9805):1812-23 [22098854] Clin Cancer Res. 2012 Apr 1;18(7):2012-23 [22328561] Cancer Res. 2012 Aug 15;72(16):4074-84 [22700878] Genome Res. 2012 Sep;22(9):1760-74 [22955987] Nature. 2012 Sep 6;489(7414):101-8 [22955620] Bioinformatics. 2013 Jan 15;29(2):273-4 [23172860] Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7413-7 [23589849] Nature. 2013 Jul 4;499(7456):43-9 [23792563] Nucleic Acids Res. 2014 Jan;42(Database issue):D756-63 [24259432] Genome Res. 2014 Feb;24(2):212-26 [24265505] Mol Oncol. 2014 May;8(3):669-78 [24560446] Nat Biotechnol. 2014 Sep;32(9):903-14 [25150838] Nature. 2002 Jan 24;415(6870):436-42 [11807556] Nature. 2002 Jan 31;415(6871):530-6 [11823860] Nat Med. 2002 Aug;8(8):816-24 [12118244] Nat Rev Cancer. 2004 Mar;4(3):177-83 [14993899] J Clin Invest. 2004 Mar;113(6):913-23 [15067324] Oncogene. 1991 Sep;6(9):1555-9 [1923522] J Clin Oncol. 1993 Aug;11(8):1466-77 [8336186] Blood. 2005 Jan 1;105(1):301-7 [15345589] Cancer Cell. 2005 Apr;7(4):337-50 [15837623] J Clin Oncol. 2005 Oct 10;23(29):7332-41 [16145063] Nat Biotechnol. 2006 Sep;24(9):1151-61 [16964229] J Natl Cancer Inst. 2006 Sep 6;98(17):1193-203 [16954472] Genome Biol. 2006;7 Suppl 1:S12.1-14 [16925834] Nat Biotechnol. 2006 Sep;24(9):1162-9 [17061323] J Clin Oncol. 2006 Nov 1;24(31):5070-8 [17075126] Lancet. 2007 Jun 23;369(9579):2106-20 [17586306] Science. 2008 Aug 15;321(5891):956-60 [18599741] Bioinformatics. 2009 May 1;25(9):1105-11 [19289445] Lancet Oncol. 2009 Jul;10(7):663-71 [19515614] Pharmacogenomics J. 2010 Aug;10(4):258-66 [20676065] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s13059-015-0694-1 ER - TY - JOUR T1 - Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. AN - 1691596897; 26010811 AB - Activation of Toll-like receptors has been linked to neuropathic pain and opioid dependence. (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been shown to reverse neuropathic pain in rat studies. We designed and synthesized compounds based on (+)-naltrexone and (+)-noroxymorphone and evaluated their TLR4 antagonist activities by their effects on inhibiting lipopolysaccharide (LPS) induced TLR4 downstream nitric oxide (NO) production in microglia BV-2 cells. Alteration of the N-substituent in (+)-noroxymorphone gave us a potent TLR4 antagonist. The most promising analog, (+)-N-phenethylnoroxymorphone ((4S,4aR,7aS,12bR)-4a,9-dihydroxy-3-phenethyl-2,3,4,4a,5,6-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7(7aH)-one, 1j) showed ∼75 times better TLR-4 antagonist activity than (+)-naltrexone, and the ratio of its cell viability IC50, a measure of its toxicity, to TLR-4 antagonist activity (140 μM/1.4 μM) was among the best of the new analogs. This compound (1j) was active in vivo; it significantly increased and prolonged morphine analgesia. JF - Journal of medicinal chemistry AU - Selfridge, Brandon R AU - Wang, Xiaohui AU - Zhang, Yingning AU - Yin, Hang AU - Grace, Peter M AU - Watkins, Linda R AU - Jacobson, Arthur E AU - Rice, Kenner C AD - †Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, Intramural Research Program, National Institute on Drug Abuse and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, 9800 Medical Center Drive, Bethesda, Maryland 20892-3373, United States. ; ‡Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado 80309, United States. ; §Department of Chemistry and Biochemistry the BioFrontiers Institute, University of Colorado at Boulder, Boulder, Colorado 80309, United States. Y1 - 2015/06/25/ PY - 2015 DA - 2015 Jun 25 SP - 5038 EP - 5052 VL - 58 IS - 12 KW - Analgesics, Opioid KW - 0 KW - Lipopolysaccharides KW - Morphinans KW - Toll-Like Receptor 4 KW - Nitric Oxide KW - 31C4KY9ESH KW - Naltrexone KW - 5S6W795CQM KW - Morphine KW - 76I7G6D29C KW - noroxymorphone KW - 9NZ7111A9O KW - Index Medicus KW - Animals KW - Humans KW - Structure-Activity Relationship KW - Morphine -- pharmacology KW - Rats KW - Rats, Sprague-Dawley KW - Lipopolysaccharides -- immunology KW - Analgesics, Opioid -- pharmacology KW - Microglia -- cytology KW - Microglia -- immunology KW - Nitric Oxide -- immunology KW - Drug Synergism KW - Microglia -- drug effects KW - Cell Line KW - Male KW - Toll-Like Receptor 4 -- immunology KW - Toll-Like Receptor 4 -- antagonists & inhibitors KW - Morphinans -- chemistry KW - Naltrexone -- analogs & derivatives KW - Naltrexone -- pharmacology KW - Morphinans -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691596897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Structure-Activity+Relationships+of+%28%2B%29-Naltrexone-Inspired+Toll-like+Receptor+4+%28TLR4%29+Antagonists.&rft.au=Selfridge%2C+Brandon+R%3BWang%2C+Xiaohui%3BZhang%2C+Yingning%3BYin%2C+Hang%3BGrace%2C+Peter+M%3BWatkins%2C+Linda+R%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Selfridge&rft.aufirst=Brandon&rft.date=2015-06-25&rft.volume=58&rft.issue=12&rft.spage=5038&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=1520-4804&rft_id=info:doi/10.1021%2Facs.jmedchem.5b00426 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-14 N1 - Date created - 2015-06-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Br J Pharmacol. 2016 Mar;173(5):856-69 [26603732] J Am Chem Soc. 1967 Apr 12;89(8):1942-7 [6040525] Mol Psychiatry. 2015 Dec;20(12):1525-37 [25644383] CNS Neurol Disord Drug Targets. 2015;14(6):692-9 [26022268] Trends Pharmacol Sci. 2014 Sep;35(9):432-3 [25109571] Trends Pharmacol Sci. 2014 Sep;35(9):431-2 [25109569] Nat Rev Drug Discov. 2014 Jul;13(7):533-48 [24948120] J Org Chem. 2014 Jun 6;79(11):5007-18 [24773391] Neuropharmacology. 2014 Jan;76 Pt B:218-27 [23764149] FASEB J. 2013 Jul;27(7):2713-22 [23568774] Chem Soc Rev. 2013 Jun 21;42(12):4859-66 [23503527] Biol Psychiatry. 2013 Apr 15;73(8):729-37 [23384483] Nat Neurosci. 2013 Mar;16(3):253-5 [23434975] J Neurosci. 2012 Aug 15;32(33):11187-200 [22895704] Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6325-30 [22474354] Pharmacol Ther. 2012 May;134(2):219-45 [22316499] Pharmacol Rev. 2011 Sep;63(3):772-810 [21752874] Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11942-7 [20547845] Cell. 2010 Mar 19;140(6):805-20 [20303872] Brain Behav Immun. 2010 Jan;24(1):83-95 [19679181] ALTEX. 2009;26(2):83-94 [19565166] Trends Neurosci. 2009 Jun;32(6):339-46 [19414201] Nature. 2009 Apr 30;458(7242):1191-5 [19252480] Org Lett. 2009 Feb 5;11(3):539-42 [19115979] Anesthesiology. 2009 Jan;110(1):166-81 [19104184] J Org Chem. 2008 Oct 17;73(20):8093-6 [18811203] Eur J Neurosci. 2008 Jul;28(1):20-9 [18662331] Neurosci Biobehav Rev. 2001 Jan;25(1):43-52 [11166077] Nat Rev Immunol. 2014 Apr;14(4):217-31 [24577438] J Med Chem. 1978 Apr;21(4):398-400 [206698] J Med Chem. 1978 Dec;21(12):1320-2 [722742] Pain. 1988 Jan;32(1):77-88 [3340425] J Med Chem. 1992 Jul 24;35(15):2826-35 [1322988] Anal Biochem. 1993 Oct;214(1):11-6 [7504409] J Neurosci Methods. 1999 Aug 1;90(1):81-6 [10517276] J Org Chem. 2005 Mar 4;70(5):1907-10 [15730320] Org Lett. 2005 Jun 23;7(13):2531-4 [15957883] ScientificWorldJournal. 2007;7:98-111 [17982582] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.jmedchem.5b00426 ER - TY - JOUR T1 - Reactive oxygen species and c-Jun N-terminal kinases contribute to TEMPO-induced apoptosis in L5178Y cells. AN - 1680960985; 25882087 AB - The biological consequences of exposure to piperidine nitroxides is a concern, given their widespread use in manufacturing processes and their potential use in clinical applications. Our previous study reported that TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl), a low molecular weight free radical, possesses pro-oxidative activity in L5178Y cells. In this study, we investigated and characterized the role of reactive oxygen species (ROS) in TEMPO-induced toxicity in L5178Y cells. We found that TEMPO induced time- and concentration-dependent intracellular ROS production and glutathione depletion. TEMPO also induced apoptosis as demonstrated by increased caspase-3/7 activity, an increased proportion of annexin V stained cells, and decreased expression of anti-apoptotic proteins including Bcl-2, Bcl-xL and Mcl-1. N-acetylcysteine, a ROS scavenger, attenuated the ROS production and apoptosis induced by TEMPO. Moreover, Western blot analyses revealed that TEMPO activated γ-H2A.X, a hallmark of DNA damage, and c-Jun N-terminal kinases (JNK), a key member in the mitogen-activated protein kinase (MAPK) signaling pathway. Addition of SP600125, a JNK-specific inhibitor, blocked TEMPO-mediated JNK phosphorylation and also attenuated TEMPO-induced apoptosis. These findings indicate that both ROS production and JNK activation are involved in TEMPO-induced apoptosis, and may contribute to the toxicity of TEMPO in L5178Y cells. Published by Elsevier Ireland Ltd. JF - Chemico-biological interactions AU - Guo, Xiaoqing AU - Chen, Si AU - Zhang, Zhuhong AU - Dobrovolsky, Vasily N AU - Dial, Stacey L AU - Guo, Lei AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States; Tianjin Medical University General Hospital, Tianjin 300052, China. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. Electronic address: nan.mei@fda.hhs.gov. Y1 - 2015/06/25/ PY - 2015 DA - 2015 Jun 25 SP - 27 EP - 36 VL - 235 KW - Bcl2l1 protein, mouse KW - 0 KW - Cyclic N-Oxides KW - Mcl1 protein, mouse KW - Myeloid Cell Leukemia Sequence 1 Protein KW - Proto-Oncogene Proteins c-bcl-2 KW - Reactive Oxygen Species KW - bcl-X Protein KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinases KW - Caspase 3 KW - EC 3.4.22.- KW - Caspase 7 KW - Glutathione KW - GAN16C9B8O KW - TEMPO KW - VQN7359ICQ KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - MAPK pathway KW - Apoptosis KW - Reactive oxygen species KW - Nitroxide KW - Animals KW - Mitogen-Activated Protein Kinases -- metabolism KW - Caspase 7 -- metabolism KW - Glutathione -- metabolism KW - Signal Transduction -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Acetylcysteine -- metabolism KW - Mice KW - Cell Line, Tumor KW - Myeloid Cell Leukemia Sequence 1 Protein -- metabolism KW - bcl-X Protein -- metabolism KW - Phosphorylation -- drug effects KW - Caspase 3 -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Apoptosis -- drug effects KW - Cyclic N-Oxides -- pharmacology KW - JNK Mitogen-Activated Protein Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680960985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemico-biological+interactions&rft.atitle=Reactive+oxygen+species+and+c-Jun+N-terminal+kinases+contribute+to+TEMPO-induced+apoptosis+in+L5178Y+cells.&rft.au=Guo%2C+Xiaoqing%3BChen%2C+Si%3BZhang%2C+Zhuhong%3BDobrovolsky%2C+Vasily+N%3BDial%2C+Stacey+L%3BGuo%2C+Lei%3BMei%2C+Nan&rft.aulast=Guo&rft.aufirst=Xiaoqing&rft.date=2015-06-25&rft.volume=235&rft.issue=&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Chemico-biological+interactions&rft.issn=1872-7786&rft_id=info:doi/10.1016%2Fj.cbi.2015.04.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-27 N1 - Date created - 2015-05-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.cbi.2015.04.009 ER - TY - JOUR T1 - FDA Approval: Belinostat for the Treatment of Patients with Relapsed or Refractory Peripheral T-cell Lymphoma AN - 1808647305; PQ0003435548 AB - On July 3, 2014, the FDA granted accelerated approval for belinostat (Beleodaq; Spectrum Pharmaceuticals, Inc.), a histone deacetylase inhibitor, for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). A single-arm, open-label, multicenter, international trial in the indicated patient population was submitted in support of the application. Belinostat was administered intravenously at a dose of 1000 mg/m2 over 30 minutes once daily on days 1 to 5 of a 21-day cycle. The primary efficacy endpoint was overall response rate (ORR) based on central radiology readings by an independent review committee. The ORR was 25.8% [95% confidence interval (CI), 18.3-34.6] in 120 patients that had confirmed diagnoses of PTCL by the Central Pathology Review Group. The complete and partial response rates were 10.8% (95% CI, 5.9-17.8) and 15.0% (95% CI, 9.1-22.7), respectively. The median duration of response, the key secondary efficacy endpoint, was 8.4 months (95% CI, 4.5-29.4). The most common adverse reactions (>25%) were nausea, fatigue, pyrexia, anemia, and vomiting. Grade 3/4 toxicities ( greater than or equal to 5.0%) included anemia, thrombocytopenia, dyspnea, neutropenia, fatigue, and pneumonia. Belinostat is the third drug to receive accelerated approval for the treatment of relapsed or refractory PTCL. Clin Cancer Res; 21(12); 2666-70. copyright 2015 AACR. JF - Clinical Cancer Research AU - Lee, Hyon-Zu AU - Kwitkowski, Virginia E AU - Del Valle, Pedro L AU - Ricci, MStacey AU - Saber, Haleh AU - Habtemariam, Bahru A AU - Bullock, Julie AU - Bloomquist, Erik AU - Li Shen, Yuan AU - Chen, Xiao-Hong AU - Brown, Janice AU - Mehrotra, Nitin AU - Dorff, Sarah AU - Charlab, Rosane AU - Kane, Robert C AU - Kaminskas, Edvardas AU - Justice, Robert AU - Farrell, Ann T AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Office of New Drugs, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, Hyon.Lee@fda.hhs.gov Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 2666 EP - 2670 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 21 IS - 12 SN - 1078-0432, 1078-0432 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Histone deacetylase KW - Vomiting KW - Fatigue KW - Respiration KW - Anemia KW - Toxicity KW - Radiology KW - Clinical trials KW - Cancer KW - Fever KW - Neutropenia KW - Thrombocytopenia KW - Pharmaceuticals KW - Nausea KW - Language KW - T-cell lymphoma KW - Dyspnea KW - Pneumonia KW - Side effects KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808647305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=FDA+Approval%3A+Belinostat+for+the+Treatment+of+Patients+with+Relapsed+or+Refractory+Peripheral+T-cell+Lymphoma&rft.au=Lee%2C+Hyon-Zu%3BKwitkowski%2C+Virginia+E%3BDel+Valle%2C+Pedro+L%3BRicci%2C+MStacey%3BSaber%2C+Haleh%3BHabtemariam%2C+Bahru+A%3BBullock%2C+Julie%3BBloomquist%2C+Erik%3BLi+Shen%2C+Yuan%3BChen%2C+Xiao-Hong%3BBrown%2C+Janice%3BMehrotra%2C+Nitin%3BDorff%2C+Sarah%3BCharlab%2C+Rosane%3BKane%2C+Robert+C%3BKaminskas%2C+Edvardas%3BJustice%2C+Robert%3BFarrell%2C+Ann+T%3BPazdur%2C+Richard&rft.aulast=Lee&rft.aufirst=Hyon-Zu&rft.date=2015-06-15&rft.volume=21&rft.issue=12&rft.spage=2666&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-3119 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Fatigue; Vomiting; Respiration; Anemia; Toxicity; Radiology; Clinical trials; Cancer; Fever; Neutropenia; Thrombocytopenia; Pharmaceuticals; Language; Nausea; T-cell lymphoma; Dyspnea; Side effects; Pneumonia DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-3119 ER - TY - JOUR T1 - Mechanisms of tolvaptan-induced toxicity in HepG2 cells. AN - 1684431233; 25858412 AB - Tolvaptan, a vasopressin receptor 2 antagonist used to treat hyponatremia, has recently been reported to be associated with an increased risk of liver injury. In this study, we explored the underlying mechanisms of hepatotoxicity of tolvaptan using human HepG2 cells. Tolvaptan inhibited cell growth and caused cell death in a concentration- and time-dependent manner. Tolvaptan treatment led to delayed cell cycle progression, accompanied by decreased levels of several cyclins and cyclin-dependent kinases. Tolvaptan was found to cause DNA damage, as assessed by alkaline comet assays; this was confirmed by increased levels of 8-oxoguanine and phosphorylation of histone H2AX. Exposure of HepG2 cells to tolvaptan enhanced cytochrome C release and triggered apoptosis by modulating Bcl-2 family members. The activation of p38 contributed to tolvaptan-mediated apoptosis via down-regulation of Bcl-2. Proteasome inhibition altered tolvaptan-induced cell cycle deregulation and enhanced tolvaptan-induced apoptosis and cytotoxicity. Moreover, tolvaptan treatment induced autophagy. Inhibition of autophagy by knocking-down an autophagy-related gene increased tolvaptan-induced apoptosis and cytotoxicity. Taken together, our findings suggest that the cytotoxicity of tolvaptan results from delayed cell cycle progression, the induction of DNA damage, and the execution of apoptosis. In addition, a number of signaling pathways were perturbed by tolvaptan and played an important role in its cytotoxicity. Published by Elsevier Inc. JF - Biochemical pharmacology AU - Wu, Yuanfeng AU - Beland, Frederick A AU - Chen, Si AU - Liu, Fang AU - Guo, Lei AU - Fang, Jia-Long AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, USA. Electronic address: jia-long.fang@fda.hhs.gov. Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 324 EP - 336 VL - 95 IS - 4 KW - Antidiuretic Hormone Receptor Antagonists KW - 0 KW - Benzazepines KW - Cyclin D3 KW - Proteasome Inhibitors KW - tolvaptan KW - 21G72T1950 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Cyclin-Dependent Kinase 4 KW - EC 2.7.11.22 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Liver injury KW - DNA damage KW - Apoptosis KW - Autophagy KW - Tolvaptan KW - Proteasome KW - Autophagy -- drug effects KW - Proteasome Inhibitors -- pharmacology KW - Mitogen-Activated Protein Kinases -- metabolism KW - Cyclin D3 -- metabolism KW - Enzyme Activation KW - Humans KW - Proteasome Endopeptidase Complex -- drug effects KW - Cytochrome P-450 CYP3A -- genetics KW - Cell Death -- drug effects KW - Cell Proliferation KW - DNA Damage -- drug effects KW - Cyclin-Dependent Kinase 4 -- metabolism KW - Proteasome Endopeptidase Complex -- metabolism KW - Hep G2 Cells KW - Cytochrome P-450 CYP3A -- metabolism KW - Apoptosis -- drug effects KW - Cell Cycle -- drug effects KW - Benzazepines -- toxicity KW - Antidiuretic Hormone Receptor Antagonists -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684431233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+pharmacology&rft.atitle=Mechanisms+of+tolvaptan-induced+toxicity+in+HepG2+cells.&rft.au=Wu%2C+Yuanfeng%3BBeland%2C+Frederick+A%3BChen%2C+Si%3BLiu%2C+Fang%3BGuo%2C+Lei%3BFang%2C+Jia-Long&rft.aulast=Wu&rft.aufirst=Yuanfeng&rft.date=2015-06-15&rft.volume=95&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Biochemical+pharmacology&rft.issn=1873-2968&rft_id=info:doi/10.1016%2Fj.bcp.2015.03.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-12 N1 - Date created - 2015-05-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcp.2015.03.015 ER - TY - JOUR T1 - Metal contamination of home garden soils and cultivated vegetables in the province of Brescia, Italy: implications for human exposure. AN - 1671213137; 25777956 AB - For the past century, ferroalloy industries in Brescia province, Italy produced particulate emissions enriched in manganese (Mn), lead (Pb), zinc (Zn), copper (Cu), cadmium (Cd), chromium (Cr), iron (Fe), and aluminum (Al). This study assessed metal concentrations in soil and vegetables of regions with varying ferroalloy industrial activity levels. Home gardens (n=63) were selected in three regions of varying ferroalloy plant activity durations in Brescia province. Total soil metal concentration and extractability were measured by X-Ray Fluorescence (XRF), aqua regia extraction, and modified Community Bureau of Reference (BCR) sequential extraction. Unwashed and washed spinach and turnips cultivated in the same gardens were analyzed for metal concentrations by flame atomic absorption spectrometry. Median soil Al, Cd, Fe, Mn, Pb, and Zn concentrations were significantly higher in home gardens near ferroalloy plants compared to reference home gardens. The BCR method yielded the most mobile soil fraction (the sum of extractable metals in Fractions 1 and 2) and all metal concentrations were higher in ferroalloy plant areas. Unwashed spinach showed higher metal concentrations compared to washed spinach. However, some metals in washed spinach were higher in the reference area likely due to history of agricultural product use. Over 60% of spinach samples exceeded the 2- to 4-fold Commission of European Communities and Codex Alimentarius Commission maximum Pb concentrations, and 10% of the same spinach samples exceeded 2- to 3-fold maximum Cd concentrations set by both organizations. Turnip metal concentrations were below maximum standard reference values. Prolonged industrial emissions increase median metal concentrations and most soluble fractions (BCR F1+F2) in home garden soils near ferroalloy plants. Areas near ferroalloy plant sites had spinach Cd and Pb metal concentrations several-fold above maximum standard references. We recommend thorough washing of vegetables to minimize metal exposure. Copyright © 2015 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Ferri, Roberta AU - Hashim, Dana AU - Smith, Donald R AU - Guazzetti, Stefano AU - Donna, Filippo AU - Ferretti, Enrica AU - Curatolo, Michele AU - Moneta, Caterina AU - Beone, Gian Maria AU - Lucchini, Roberto G AD - Occupational Health, University of Brescia, Italy. ; Occupational and Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, USA. ; Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA. ; Public Health Service, Reggio Emilia, Italy. ; Department of Food Chemistry, Metal Laboratory, IZSLER, Brescia, Italy. ; Institute of Agricultural and Environmental Chemistry, Università Cattolica, Piacenza, Italy. ; Occupational Health, University of Brescia, Italy; Occupational and Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, USA; Microbiology and Environmental Toxicology, University of California, Santa Cruz, CA, USA. Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 507 EP - 517 VL - 518-519 KW - Metals KW - 0 KW - Soil KW - Soil Pollutants KW - Index Medicus KW - Phytoavailability KW - Vegetables KW - Ferroalloy industry emissions KW - Metal KW - Modified BCR sequential extraction procedure KW - Brescia KW - Plant uptake KW - Italy KW - Environmental Monitoring KW - Humans KW - Gardening KW - Vegetables -- chemistry KW - Environmental Exposure -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Soil -- chemistry KW - Metals -- analysis KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671213137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Metal+contamination+of+home+garden+soils+and+cultivated+vegetables+in+the+province+of+Brescia%2C+Italy%3A+implications+for+human+exposure.&rft.au=Ferri%2C+Roberta%3BHashim%2C+Dana%3BSmith%2C+Donald+R%3BGuazzetti%2C+Stefano%3BDonna%2C+Filippo%3BFerretti%2C+Enrica%3BCuratolo%2C+Michele%3BMoneta%2C+Caterina%3BBeone%2C+Gian+Maria%3BLucchini%2C+Roberto+G&rft.aulast=Ferri&rft.aufirst=Roberta&rft.date=2015-06-15&rft.volume=518-519&rft.issue=&rft.spage=507&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2015.02.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-11 N1 - Date created - 2015-04-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2004 Feb;112(2):215-21 [14754576] Environ Int. 2004 Jun;30(4):467-70 [15031005] Environ Geochem Health. 2004 Mar;26(1):27-36 [15214611] Ecotoxicol Environ Saf. 1997 Apr;36(3):258-68 [9143454] Anal Bioanal Chem. 2004 Nov;380(5-6):813-7 [15517201] Environ Int. 2005 Aug;31(6):784-90 [15979144] Environ Sci Technol. 2005 Oct 1;39(19):7410-5 [16245809] Bull Environ Contam Toxicol. 2006 Feb;76(2):311-9 [16468012] Environ Res. 2006 May;101(1):1-10 [16171795] Chemosphere. 2006 Jun;64(1):161-73 [16330080] Environ Pollut. 2007 Jan;145(1):121-30 [16777287] Sci Total Environ. 2007 Sep 20;383(1-3):81-9 [17573096] J Environ Sci Health A Tox Hazard Subst Environ Eng. 2007 Jul 15;42(9):1241-50 [17654144] Am J Ind Med. 2007 Nov;50(11):788-800 [17918215] Chemosphere. 2008 Feb;70(8):1459-67 [17936872] Environ Pollut. 2008 Mar;152(2):330-41 [17655986] Public Health Nutr. 2009 Dec;12(12):2504-32 [19278564] J Environ Qual. 2010 Sep-Oct;39(5):1616-23 [21043267] Environ Monit Assess. 2011 Jan;172(1-4):319-27 [20165975] Environ Monit Assess. 2011 Apr;175(1-4):303-14 [20499161] J Hazard Mater. 2011 Jun 15;190(1-3):177-87 [21470776] Int J Environ Res Public Health. 2011 Jun;8(6):1805-16 [21776203] J Food Sci. 2011 Oct;76(8):T181-8 [21913923] Environ Pollut. 2012 Jun;165:124-32 [22445920] J Trace Elem Med Biol. 2012 Jun;26(2-3):179-82 [22664337] Neurotoxicology. 2012 Aug;33(4):687-96 [22322213] Environ Sci Pollut Res Int. 2013 Jul;20(7):5067-75 [23338992] Neurotoxicology. 2014 Dec;45:309-17 [24881811] J Environ Monit. 2000 Jun;2(3):228-33 [11256704] J Environ Monit. 1999 Feb;1(1):57-61 [11529080] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2015.02.072 ER - TY - JOUR T1 - Sensitive detection of active Shiga toxin using low cost CCD based optical detector. AN - 1660413065; 25677808 AB - To reduce the sources and incidence of food-borne illness there is a need to develop affordable, sensitive devices for detection of active toxins, such as Shiga toxin type 2 (Stx2). Currently the widely used methods for measuring Shiga toxin are immunoassay that cannot distinguish between the active form of the toxin, which poses a threat to life, to the inactive form which can bind to antibodies but show no toxicity. In this work, we determine toxin activity based on Shiga toxin inhibition of green fluorescent protein (GFP) combined with low cost charge-coupled device (CCD) fluorescence detection, which is more clinically relevant than immunoassay. For assay detection, a simple low cost fluorescence detection system was constructed using a CCD camera and light emitting diode (LED) excitation source, to measure GFP expression. The system was evaluated and compared to a commercial fluorometer using photomultiplier detection for detecting active Stx2 in the range 100 ng/mL-0.01 pg/mL. The result shows that there is a negative linear relationship between Stx2 concentrations and luminous intensity of GFP, imaged by the CCD camera (R(2)=0.85) or fluorometer (R(2)=0.86). The low cost (∼$300) CCD camera is capable of detecting Shiga toxin activity at comparable levels as a more expensive (∼$30,000) fluorometer. These results demonstrate the utility and the potential of low cost detectors for toxin activity; this approach may increase the availability of foodborne bacterial toxin diagnostics in regions where there are limited resources and could be readily adapted to the detection of other food-borne toxins. Published by Elsevier B.V. JF - Biosensors & bioelectronics AU - Rasooly, Reuven AU - Balsam, Josh AU - Hernlem, Bradley J AU - Rasooly, Avraham AD - Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, United States. Electronic address: reuven.rasooly@ars.usda.gov. ; Division of Biology, Office of Science and Engineering, FDA, Silver Spring, MD 20993, United States; University of Maryland, College Park, MD 20742, United States. ; Western Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture, Albany, CA, United States. ; Division of Biology, Office of Science and Engineering, FDA, Silver Spring, MD 20993, United States; Office of Cancer Complementary and Alternative Medicine, National Cancer Institute, Rockville, MD 20850, United States. Y1 - 2015/06/15/ PY - 2015 DA - 2015 Jun 15 SP - 705 EP - 711 VL - 68 KW - Shiga Toxin 2 KW - 0 KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Food KW - Adenovirus KW - CCD camera KW - Shiga toxin KW - Humans KW - Food Analysis KW - Shiga Toxin 2 -- isolation & purification KW - Biosensing Techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660413065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+%26+bioelectronics&rft.atitle=Sensitive+detection+of+active+Shiga+toxin+using+low+cost+CCD+based+optical+detector.&rft.au=Rasooly%2C+Reuven%3BBalsam%2C+Josh%3BHernlem%2C+Bradley+J%3BRasooly%2C+Avraham&rft.aulast=Rasooly&rft.aufirst=Reuven&rft.date=2015-06-15&rft.volume=68&rft.issue=&rft.spage=705&rft.isbn=&rft.btitle=&rft.title=Biosensors+%26+bioelectronics&rft.issn=1873-4235&rft_id=info:doi/10.1016%2Fj.bios.2015.01.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-25 N1 - Date created - 2015-03-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bios.2015.01.065 ER - TY - JOUR T1 - Surveillance of antibiotic resistance AN - 1808698139; PQ0003431084 AB - Surveillance involves the collection and analysis of data for the detection and monitoring of threats to public health. Surveillance should also inform as to the epidemiology of the threat and its burden in the population. A further key component of surveillance is the timely feedback of data to stakeholders with a view to generating action aimed at reducing or preventing the public health threat being monitored. Surveillance of antibiotic resistance involves the collection of antibiotic susceptibility test results undertaken by microbiology laboratories on bacteria isolated from clinical samples sent for investigation. Correlation of these data with demographic and clinical data for the patient populations from whom the pathogens were isolated gives insight into the underlying epidemiology and facilitates the formulation of rational interventions aimed at reducing the burden of resistance. This article describes a range of surveillance activities that have been undertaken in the UK over a number of years, together with current interventions being implemented. These activities are not only of national importance but form part of the international response to the global threat posed by antibiotic resistance. JF - Philosophical Transactions of the Royal Society of London, Series B: Biological Sciences AU - Johnson, Alan P AD - Department of Healthcare-Associated Infection and Antimicrobial Resistance, Centre for Infectious Disease Surveillance and Control, , Public Health England, London NW9 5EQ, UK, alan.johnson@phe.gov.uk Y1 - 2015/06/05/ PY - 2015 DA - 2015 Jun 05 SP - 20140080 PB - Royal Society of London, 6 Carlton House Terrace London SW1Y 5AG United Kingdom VL - 370 IS - 1670 SN - 0962-8436, 0962-8436 KW - Ecology Abstracts KW - antibiotic susceptibility testing KW - public health threat KW - interventions KW - Demography KW - Data processing KW - Epidemiology KW - Antibiotics KW - Feedback KW - Pathogens KW - Antibiotic resistance KW - Public health KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808698139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Philosophical+Transactions+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.atitle=Surveillance+of+antibiotic+resistance&rft.au=Johnson%2C+Alan+P&rft.aulast=Johnson&rft.aufirst=Alan&rft.date=2015-06-05&rft.volume=370&rft.issue=1670&rft.spage=20140080&rft.isbn=&rft.btitle=&rft.title=Philosophical+Transactions+of+the+Royal+Society+of+London%2C+Series+B%3A+Biological+Sciences&rft.issn=09628436&rft_id=info:doi/10.1098%2Frstb.2014.0080 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Demography; Data processing; Epidemiology; Feedback; Antibiotics; Pathogens; Antibiotic resistance; Public health DO - http://dx.doi.org/10.1098/rstb.2014.0080 ER - TY - JOUR T1 - Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study. AN - 1686415287; 24863738 AB - In vitro-derived information has been increasingly used to support and improve human health risk assessment for exposure to chemicals. Physiologically based pharmacokinetic (PBPK) modeling is a key component in the movement toward in vitro-based risk assessment, providing a tool to integrate diverse experimental data and mechanistic information to relate in vitro effective concentrations to equivalent human exposures. One of the challenges, however, in the use of PBPK models for this purpose has been the need for extensive chemical-specific parameters. With the remarkable advances in in vitro methodologies in recent years, in vitro-derived parameters can now be easily incorporated into PBPK models. In this study we demonstrate an in vitro data based parameterization approach to develop a physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) model, using carbaryl as a case study. In vitro experiments were performed to provide the chemical-specific pharmacokinetic (PK) and pharmacodynamic (PD) parameters for carbaryl in the PBPK model for this compound. Metabolic clearance and cholinesterase (ChE) interaction parameters for carbaryl were measured in rat and human tissues. These in vitro PK and PD data were extrapolated to parameters in the whole body PBPK model using biologically appropriate scaling. The PBPK model was then used to predict the kinetics and ChE inhibition dynamics of carbaryl in vivo. This case study with carbaryl provides a reasonably successful example of utilizing the in vitro to in vivo extrapolation (IVIVE) approach for PBPK model development. This approach can be applied to other carbamates with an anticholinesterase mode of action as well as to environmental chemicals in general with further refinement of the current shortcomings in the approach. It will contribute to minimizing the need for in vivo human data for PBPK model parameterization and evaluation in human risk assessments. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology AU - Yoon, Miyoung AU - Kedderis, Gregory L AU - Yan, Grace Zhixia AU - Clewell, Harvey J AD - Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address: myoon@thehamner.org. ; Independent Consultant, Chapel Hill, NC, USA. Electronic address: gkedderis@msn.com. ; Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address: Zhixia.Yan@fda.hhs.gov. ; Center for Human Health Assessment, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address: hclewell@thehamner.org. Y1 - 2015/06/05/ PY - 2015 DA - 2015 Jun 05 SP - 52 EP - 66 VL - 332 KW - Cholinesterase Inhibitors KW - 0 KW - Cholinesterases KW - EC 3.1.1.8 KW - Carbaryl KW - R890C8J3N1 KW - Index Medicus KW - In vitro to in vivo extrapolation KW - Cholinesterase inhibition KW - Hepatocytes KW - PBPK model KW - Metabolism KW - Young Adult KW - Animal Testing Alternatives KW - Animals KW - Erythrocytes -- drug effects KW - Hepatocytes -- drug effects KW - Computer Simulation KW - Humans KW - Brain -- drug effects KW - Linear Models KW - Metabolic Clearance Rate KW - Hepatocytes -- enzymology KW - Risk Assessment KW - Brain -- enzymology KW - Rats, Sprague-Dawley KW - Erythrocytes -- enzymology KW - Biotransformation KW - Cells, Cultured KW - Risk Factors KW - Adult KW - Middle Aged KW - Species Specificity KW - Male KW - Female KW - Cholinesterases -- metabolism KW - Cholinesterase Inhibitors -- toxicity KW - Toxicity Tests -- methods KW - Cholinesterase Inhibitors -- pharmacokinetics KW - Cholinesterase Inhibitors -- blood KW - Carbaryl -- toxicity KW - Carbaryl -- pharmacokinetics KW - Carbaryl -- blood KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686415287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Use+of+in+vitro+data+in+developing+a+physiologically+based+pharmacokinetic+model%3A+Carbaryl+as+a+case+study.&rft.au=Yoon%2C+Miyoung%3BKedderis%2C+Gregory+L%3BYan%2C+Grace+Zhixia%3BClewell%2C+Harvey+J&rft.aulast=Yoon&rft.aufirst=Miyoung&rft.date=2015-06-05&rft.volume=332&rft.issue=&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2014.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-13 N1 - Date created - 2015-06-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2014.05.006 ER - TY - JOUR T1 - Characterisation and potential migration of silver nanoparticles from commercially available polymeric food contact materials AN - 1694983241; PQ0001611034 AB - The potential for consumer exposure to nano-components in food contact materials (FCMs) is dependent on the migration of nanomaterials into food. Therefore, characterising the physico-chemical properties and potential for migration of constituents is an important step in assessing the safety of FCMs. A number of commercially available food storage products, purchased domestically within the United States and internationally, that claim to contain nanosilver were evaluated. The products were made of polyethylene, polypropylene and polyphenylene ether sulfone and all contained silver (0.001-36 mg kg super(-1) of polymer). Silver migration was measured under various conditions, including using 3% acetic acid and water as food simulants. Low concentrations (sub-ppb levels) of silver were detected in the migration studies generally following a trend characterised by a surface desorption phenomenon, where the majority of the silver migration occurred in the first of three consecutive exposures. Silver nanoparticles were not detected in food simulants, suggesting that the silver migration may be due solely to ionic silver released into solution from oxidation of the silver nanoparticle surface. The absence of detectable silver nanoparticles was consistent with expectations from a physico-chemical view point. For the products tested, current USFDA guidance for evaluating migration from FCMs was applicable. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Addo Ntim, Susana AU - Thomas, Treye A AU - Begley, Timothy H AU - Noonan, Gregory O AD - US Food and Drug Administration (USFDA), Center for Food Safety and Applied Nutrition, College Park, MD, USA Y1 - 2015/06/03/ PY - 2015 DA - 2015 Jun 03 SP - 1003 EP - 1011 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 6 SN - 1944-0049, 1944-0049 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Risk assessment KW - Desorption KW - Physicochemical properties KW - Safety KW - Migration KW - Nanotechnology KW - USA KW - Food additives KW - Oxidation KW - Food storage KW - Ethers KW - Polymers KW - Silver KW - H 9000:Consumer and Recreation Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694983241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Characterisation+and+potential+migration+of+silver+nanoparticles+from+commercially+available+polymeric+food+contact+materials&rft.au=Addo+Ntim%2C+Susana%3BThomas%2C+Treye+A%3BBegley%2C+Timothy+H%3BNoonan%2C+Gregory+O&rft.aulast=Addo+Ntim&rft.aufirst=Susana&rft.date=2015-06-03&rft.volume=32&rft.issue=6&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1029994 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food additives; Desorption; Oxidation; Safety; Physicochemical properties; Food storage; Ethers; Polymers; Migration; Silver; Nanotechnology; USA DO - http://dx.doi.org/10.1080/19440049.2015.1029994 ER - TY - JOUR T1 - Development and utility of the FDA 'GutProbe' DNA microarray for identification, genotyping and metagenomic analysis of commercially available probiotics AN - 1787984438; PQ0002928257 AB - Aim Lactic acid bacteria are beneficial microbes added to many food products and dietary supplements for their purported health benefits. Proper identification of bacteria is important to assess safety as well as proper product labelling. A custom microarray (FDA GutProbe) was developed to verify accurate labelling in commercial dietary supplements. Methods and Results Strain-specific attribution was achieved with GutProbe array which contains genes from the most commonly found species in probiotic supplements and food ingredients. Applied utility of the array was assessed with direct from product DNA hybridization to determine (i) if identification of multiple strains in one sample can be conducted and (ii) if any lot-to-lot variations exist with eight probiotics found on the US market. Conclusions GutProbe is a useful tool in identifying a mixture of microbials in probiotics and did reveal some product variations. In addition, the array is able to identify lot-to-lot differences in these products. These strain level attribution may be useful for routine monitoring of batch variation as part of a 'Good Manufacturing Practices' process. Significance and Impact of the Study The FDA GutProbe is an efficient and reliable platform to identify the presence of microbial ingredients and determining microbe differences in dietary supplements. The GutProbe is a fast, rapid method for direct community profiling or food matrix sampling. JF - Journal of Applied Microbiology AU - Patro, J N AU - Ramachandran, P AU - Lewis, J L AU - Mammel, M K AU - Barnaba, T AU - Pfeiler, E A AU - Elkins, CA AD - Division of Molecular Biology, Center for Food Safety & Applied Nutrition, U.S. Food and Drug Administration, Muirkirk Rd Laurel, MD, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1478 EP - 1488 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 118 IS - 6 SN - 1364-5072, 1364-5072 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Environment Abstracts KW - Dietary supplements KW - Food KW - Genotyping KW - Safety KW - FDA KW - DNA KW - probiotics KW - Sampling KW - Lactic acid bacteria KW - DNA microarrays KW - J 02310:Genetics & Taxonomy KW - W 30910:Imaging KW - A 01330:Food Microbiology KW - ENA 21:Wildlife KW - N 14810:Methods KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787984438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Development+and+utility+of+the+FDA+%27GutProbe%27+DNA+microarray+for+identification%2C+genotyping+and+metagenomic+analysis+of+commercially+available+probiotics&rft.au=Patro%2C+J+N%3BRamachandran%2C+P%3BLewis%2C+J+L%3BMammel%2C+M+K%3BBarnaba%2C+T%3BPfeiler%2C+E+A%3BElkins%2C+CA&rft.aulast=Patro&rft.aufirst=J&rft.date=2015-06-01&rft.volume=118&rft.issue=6&rft.spage=1478&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.12795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Genotyping; Food; Dietary supplements; probiotics; Lactic acid bacteria; Sampling; DNA microarrays; Safety; DNA; FDA DO - http://dx.doi.org/10.1111/jam.12795 ER - TY - JOUR T1 - Comment on "Concerns with amplitude variation in calibrated audiometer systems in clinical simulations" AN - 1787974031; PQ0002994323 JF - Noise and Health AU - Byrne, David C AU - Themann, Christa L AU - Stephenson, Mark R AD - Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 172 PB - University College London, 330 Gray's Inn Road London WC1X 8EE United Kingdom VL - 17 IS - 76 SN - 1463-1741, 1463-1741 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1787974031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+and+Health&rft.atitle=Comment+on+%22Concerns+with+amplitude+variation+in+calibrated+audiometer+systems+in+clinical+simulations%22&rft.au=Byrne%2C+David+C%3BThemann%2C+Christa+L%3BStephenson%2C+Mark+R&rft.aulast=Byrne&rft.aufirst=David&rft.date=2015-06-01&rft.volume=17&rft.issue=76&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=Noise+and+Health&rft.issn=14631741&rft_id=info:doi/10.4103%2F1463-1741.155851 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-05-11 DO - http://dx.doi.org/10.4103/1463-1741.155851 ER - TY - JOUR T1 - Developing osteoblasts as an endpoint for the mouse embryonic stem cell test AN - 1735915928; PQ0002267949 AB - The mouse Embryonic Stem cell Test (EST) using cardiomyocyte differentiation is a promising in vitro assay for detecting potential embryotoxicity; however, the addition of another differentiation endpoint, such as osteoblasts, may improve the predictive value of the test. A number of variables such as culture conditions and starting cell number were investigated. A 14 day direct plating method of D3 mouse embryonic stem cells (mESCs) was used to test the predictivity of osteoblast differentiation as an endpoint in the EST. Twelve compounds were tested using the prediction model developed in the ECVAM validation study. Eight of the compounds selected from the EST validation study served as model compounds; four additional compounds known to produce skeletal defects were also tested. Our results indicate comparable chemical classification between the validated cardiomyocyte endpoint and the osteoblast endpoint. These results suggest that differentiation to osteoblasts may provide confirmatory information in predicting embryotoxicity. JF - Reproductive Toxicology AU - Chen, Xinrong AU - Hansen, Deborah K AU - Merry, Gwenn AU - DeJarnette, Christian AU - Nolen, Greg AU - Sloper, Daniel AU - Fisher, JEdward AU - Harrouk, Wafa AU - Tassinari, Melissa S AU - Inselman, Amy L AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 131 EP - 140 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 53 SN - 0890-6238, 0890-6238 KW - Genetics Abstracts; Calcium & Calcified Tissue Abstracts; Toxicology Abstracts KW - Osteoblast KW - Cardiomyocyte KW - Embryonic stem cell test KW - Embryotoxicity KW - Alternative model KW - In vitro KW - EST Embryonic Stem cell Test KW - mESCs mouse embryonic stem cells KW - ESCs embryonic stem cells KW - EB embryoid body KW - ECVAM European Centre for the Validation of Alternative Methods KW - PMEF primary mouse embryonic fibroblasts KW - FBS fetal bovine serum KW - DMEM Dulbecco's Modified Eagle medium KW - DMSO dimethyl sulfoxide KW - 5FU 5-fluorouracil KW - HU hydroxyurea KW - DPH diphenhydramine hydrochloride KW - MTX methotrexate hydrate KW - LC lithium chloride KW - AC acrylamide KW - VPA valproic acid KW - PG penicillin G KW - ACE acetazolamide KW - CS cadmium sulfate KW - 6MP 6-mercaptopurine monohydrate KW - TH thalidomide KW - ALR alizarin red S KW - Bglap bone gamma carboxyglutamate protein KW - Oct-4 octamer-binding transcription factor 4 KW - Runx2 runt related transcription factor 2 KW - IC503T3 50% viability of 3T3 cells KW - IC50D3 50% viability of D3 cells KW - ID50Ob or CM 50% inhibition of differentiation of osteoblasts or cardiomyocytes KW - Osteoblastogenesis KW - Osteoblasts KW - Stem cells KW - Embryo cells KW - Cell number KW - Cell culture KW - cardiomyocytes KW - expressed sequence tags KW - G 07730:Development & Cell Cycle KW - T 2025:Bone and Bone Diseases KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735915928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reproductive+Toxicology&rft.atitle=Developing+osteoblasts+as+an+endpoint+for+the+mouse+embryonic+stem+cell+test&rft.au=Chen%2C+Xinrong%3BHansen%2C+Deborah+K%3BMerry%2C+Gwenn%3BDeJarnette%2C+Christian%3BNolen%2C+Greg%3BSloper%2C+Daniel%3BFisher%2C+JEdward%3BHarrouk%2C+Wafa%3BTassinari%2C+Melissa+S%3BInselman%2C+Amy+L&rft.aulast=Chen&rft.aufirst=Xinrong&rft.date=2015-06-01&rft.volume=53&rft.issue=&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Reproductive+Toxicology&rft.issn=08906238&rft_id=info:doi/10.1016%2Fj.reprotox.2015.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Osteoblasts; Osteoblastogenesis; Stem cells; Cell number; Embryo cells; Cell culture; cardiomyocytes; expressed sequence tags DO - http://dx.doi.org/10.1016/j.reprotox.2015.04.008 ER - TY - JOUR T1 - Foreword: The Global Pandemic of Falsified Medicines: Laboratory and Field Innovations and Policy Implications AN - 1727682298; PQ0002197807 AB - It is a privilege to introduce this collection of articles in the American Journal of Tropical Medicine and Hygiene on the global threat of falsified medicines. Substandard and falsified medical products pose significant risks to global health with potentially devastating and far-reaching consequences. The articles contained in this issue address this threat by exploring new technology for identifying falsified medicines, field innovations for defining their prevalence, and the broader policy implications that demand our attention. It is my hope that this collection contributes to the goal of addressing falsified medicines by identifying not only the nature and scope of a pressing global health problem but also ways to solve it. JF - American Journal of Tropical Medicine and Hygiene AU - Hamburg, Margaret AD - U.S. Food and Drug Administration, Silver Spring, Maryland, commissioner@fda.hhs.gov Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - pandemics KW - Policies KW - Medical equipment KW - Medicine KW - Hygiene KW - Q1 08121:Law, policy, economics and social sciences KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03420:Plant Diseases KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727682298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Foreword%3A+The+Global+Pandemic+of+Falsified+Medicines%3A+Laboratory+and+Field+Innovations+and+Policy+Implications&rft.au=Hamburg%2C+Margaret&rft.aulast=Hamburg&rft.aufirst=Margaret&rft.date=2015-06-01&rft.volume=92&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.15-0046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Policies; Medicine; Hygiene; pandemics; Medical equipment DO - http://dx.doi.org/10.4269/ajtmh.15-0046 ER - TY - JOUR T1 - Biotransformation of Steroids and Flavonoids by Cultures of Aspergillus niger AN - 1709180755; PQ0001900374 AB - Steroids are derivatives of the triterpenoid squalene, containing three fused cyclohexane rings and a cyclopentane ring, and flavonoids are derivatives of L-phenylalanine, containing two aromatic rings joined by a three-carbon bridge that may form part of a heterocyclic ring. A great variety of steroids and flavonoids are produced by plants, and many additional steroids are produced by animals or fungi. Because these compounds have many nutritional and pharmaceutical values, and many of them cannot be produced by chemical synthesis, biotechnological processes are being developed that use cultures of Aspergillus niger and other fungi to transform steroids and flavonoids to a variety of metabolites. These biochemical reactions, including hydroxylation, dehydrogenation, O-methylation, demethylation, cleavage of rings, epoxide hydrolysis, double bond reduction, and others, may be used for the production of higher-value compounds. JF - Applied Biochemistry and Biotechnology AU - Parshikov, Igor A AU - Sutherland, John B AD - Institute of Applied Mechanics, Russian Academy of Sciences, Moscow, 119991, Russia, john.sutherland@fda.hhs.gov Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 903 EP - 923 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 176 IS - 3 SN - 0273-2289, 0273-2289 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - triterpenoids KW - Epoxides KW - Flavonoids KW - Fungi KW - biotransformation KW - Metabolites KW - Steroid hormones KW - Hydrolysis KW - Phenylalanine KW - Hydroxylation KW - Demethylation KW - Cyclohexane KW - Dehydrogenation KW - Pharmaceuticals KW - Aspergillus niger KW - Aromatics KW - Cyclopentane KW - Squalene KW - W 30950:Waste Treatment & Pollution Clean-up KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709180755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Biochemistry+and+Biotechnology&rft.atitle=Biotransformation+of+Steroids+and+Flavonoids+by+Cultures+of+Aspergillus+niger&rft.au=Parshikov%2C+Igor+A%3BSutherland%2C+John+B&rft.aulast=Parshikov&rft.aufirst=Igor&rft.date=2015-06-01&rft.volume=176&rft.issue=3&rft.spage=903&rft.isbn=&rft.btitle=&rft.title=Applied+Biochemistry+and+Biotechnology&rft.issn=02732289&rft_id=info:doi/10.1007%2Fs12010-015-1619-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 69 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - triterpenoids; Flavonoids; Epoxides; Fungi; biotransformation; Metabolites; Steroid hormones; Phenylalanine; Hydrolysis; Hydroxylation; Demethylation; Cyclohexane; Dehydrogenation; Pharmaceuticals; Aromatics; Squalene; Cyclopentane; Aspergillus niger DO - http://dx.doi.org/10.1007/s12010-015-1619-x ER - TY - JOUR T1 - Metabolic fate of fructose in human adipocytes: a targeted super(13)C tracer fate association study AN - 1709177239; PQ0001590304 AB - The development of obesity is becoming an international problem and the role of fructose is unclear. Studies using liver tissue and hepatocytes have contributed to the understanding of fructose metabolism. Excess fructose consumption also affects extra hepatic tissues including adipose tissue. The effects of fructose on human adipocytes are not yet fully characterized, although in vivo studies have noted increased adiposity and weight gain in response to fructose sweetened-beverages. In order to understand and predict the metabolic responses of adipocytes to fructose, this study examined differentiating and differentiated human adipocytes in culture, exposed to a range of fructose concentrations equivalent to that reported in blood after consuming fructose. A stable isotope based dynamic profiling method using [U- super(13)C sub(6)]-d-fructose tracer was used to examine the metabolism and fate of fructose. A targeted stable isotope tracer fate association method was used to analyze metabolic fluxes and flux surrogates with exposure to escalating fructose concentration. This study demonstrated that fructose stimulates anabolic processes in adipocytes robustly, including glutamate and de novo fatty acid synthesis. Furthermore, fructose also augments the release of free palmitate from fully differentiated adipocytes. These results imply that in the presence of fructose, the metabolic response of adipocytes in culture is altered in a dose dependent manner, particularly favoring increased glutamate and fatty acid synthesis and release, warranting further in vivo studies. JF - Metabolomics AU - Varma, Vijayalakshmi AU - Boros, Laszlo G AU - Nolen, Greg T AU - Chang, Ching-Wei AU - Wabitsch, Martin AU - Beger, Richard D AU - Kaput, Jim AD - Division of Systems Biology, National Center for Toxicological Research, FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA, vijayalakshmi.varma@fda.hhs.gov Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 529 EP - 544 PB - OMICS Publishing Group, New York VL - 11 IS - 3 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Obesity KW - Isotopes KW - Hepatocytes KW - Blood KW - Tracers KW - Palmitic acid KW - Adipocytes KW - Fructose KW - Liver KW - Fatty acids KW - Adipose tissue KW - Glutamic acid KW - metabolic flux KW - metabolomics KW - Metabolic response KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709177239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Metabolic+fate+of+fructose+in+human+adipocytes%3A+a+targeted+super%2813%29C+tracer+fate+association+study&rft.au=Varma%2C+Vijayalakshmi%3BBoros%2C+Laszlo+G%3BNolen%2C+Greg+T%3BChang%2C+Ching-Wei%3BWabitsch%2C+Martin%3BBeger%2C+Richard+D%3BKaput%2C+Jim&rft.aulast=Varma&rft.aufirst=Vijayalakshmi&rft.date=2015-06-01&rft.volume=11&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-014-0716-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 70 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Obesity; Isotopes; Hepatocytes; Tracers; Blood; Adipocytes; Palmitic acid; Fructose; Fatty acids; Liver; Adipose tissue; Glutamic acid; metabolomics; metabolic flux; Metabolic response DO - http://dx.doi.org/10.1007/s11306-014-0716-0 ER - TY - JOUR T1 - Evaluation of Level of Agreement in Bordetella Species Identification in Three U.S. Laboratories during a Period of Increased Pertussis AN - 1709175558; PQ0001679729 AB - While PCR is the most common method used for detecting Bordetella pertussis in the United States, most laboratories use insertion sequence 481 (IS481), which is not specific for B. pertussis; therefore, the relative contribution of other Bordetella species is not understood. The objectives of this study were to evaluate the proportion of other Bordetella species misidentified as B. pertussis during a period of increased pertussis incidence, determine the level of agreement in Bordetella species detection between U.S. commercial laboratories and the CDC, and assess the relative diagnostic sensitivity of CDC's PCR assay when using a different PCR master mix. Specimens collected between May 2012 and May 2013 were tested at two U.S. commercial laboratories for B. pertussis and B. parapertussis detection. Every fifth specimen positive for IS481 and/or IS1001 with cycle threshold (CT) values of less than or equal to 35 was sent to CDC for PCR testing that identifies Bordetella species. Specimens with indeterminate or negative results in the CDC PCR were tested using an alternate PCR master mix. Of 755 specimens, there was agreement in species identification for 83.4% (n = 630). Of the specimens with different identifications (n = 125), 79.2% (n = 99) were identified as indeterminate B. pertussis at CDC. Overall, 0.66% (n = 5) of the specimens were identified as B. holmesii or B. bronchiseptica at CDC. Of 115 specimens with indeterminate or negative results, 46.1% (n = 53) were B. pertussis positive when tested by an alternate master mix, suggesting a possible increase in assay sensitivity. This study demonstrates good agreement between the two U.S. commercial laboratories and CDC and little misidentification of Bordetella species during the 2012 U.S. epidemic. JF - Journal of Clinical Microbiology AU - Burgos-Rivera, Brunilis AU - Lee, Adria D AU - Bowden, Katherine E AU - Faulkner, Amanda E AU - Seaton, Brent L AU - Lembke, Bryndon D AU - Cartwright, Charles P AU - Martin, Stacey W AU - Tondella, M Lucia AD - Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia, USA, wri2@cdc.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1842 EP - 1847 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 6 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Pertussis KW - Bordetella pertussis KW - Epidemics KW - Bordetella KW - Polymerase chain reaction KW - Insertion sequences KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709175558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+Level+of+Agreement+in+Bordetella+Species+Identification+in+Three+U.S.+Laboratories+during+a+Period+of+Increased+Pertussis&rft.au=Burgos-Rivera%2C+Brunilis%3BLee%2C+Adria+D%3BBowden%2C+Katherine+E%3BFaulkner%2C+Amanda+E%3BSeaton%2C+Brent+L%3BLembke%2C+Bryndon+D%3BCartwright%2C+Charles+P%3BMartin%2C+Stacey+W%3BTondella%2C+M+Lucia&rft.aulast=Burgos-Rivera&rft.aufirst=Brunilis&rft.date=2015-06-01&rft.volume=53&rft.issue=6&rft.spage=1842&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.03567-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 30 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Pertussis; Epidemics; Polymerase chain reaction; Insertion sequences; Bordetella pertussis; Bordetella DO - http://dx.doi.org/10.1128/JCM.03567-14 ER - TY - JOUR T1 - Successful Combination of Nucleic Acid Amplification Test Diagnostics and Targeted Deferred Neisseria gonorrhoeae Culture AN - 1709172856; PQ0001679704 AB - Nucleic acid amplification tests (NAATs) are recommended for the diagnosis of N. gonorrhoeae infections because of their superior sensitivity. Increasing NAAT use causes a decline in crucial antimicrobial resistance (AMR) surveillance data, which rely on culture. We analyzed the suitability of the ESwab system for NAAT diagnostics and deferred targeted N. gonorrhoeae culture to allow selective and efficient culture based on NAAT results. We included patients visiting the STI Clinic Amsterdam, The Netherlands, in 2013. Patient characteristics and urogenital and rectal samples for direct N. gonorrhoeae culture, standard NAAT, and ESwab were collected. Standard NAAT and NAAT on ESwab samples were performed using the Aptima Combo 2 assay for N. gonorrhoeae and C. trachomatis. Two deferred N. gonorrhoeae cultures were performed on NAAT-positive ESwab samples after storage at 4 degree C for 1 to 3 days. We included 2,452 samples from 1,893 patients. In the standard NAAT, 107 samples were N. gonorrhoeae positive and 284 were C. trachomatis positive. The sensitivities of NAAT on ESwab samples were 83% (95% confidence interval [CI], 75 to 90%) and 87% (95% CI, 82 to 90%), respectively. ESwab samples were available for 98 of the gonorrhea-positive samples. Of these, 82% were positive in direct culture and 69% and 56% were positive in the 1st and 2nd deferred cultures, respectively (median storage times, 27 and 48 h, respectively). Deferred culture was more often successful in urogenital samples or when the patient had symptoms at the sampling site. Deferred N. gonorrhoeae culture of stored ESwab samples is feasible and enables AMR surveillance. To limit the loss in NAAT sensitivity, we recommend obtaining separate samples for NAAT and deferred culture. JF - Journal of Clinical Microbiology AU - Wind, Carolien M AU - de Vries, Henry JC AU - Schim van der, Maarten F AU - Unemo, Magnus AU - van Dam, Alje P AD - STI Outpatient Clinic, Cluster of Infectious Diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands, avdam@ggd.amsterdam.nl. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1884 EP - 1890 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 6 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - nucleic acids KW - Data processing KW - Rectum KW - Drug resistance KW - Sampling KW - Infection KW - Neisseria gonorrhoeae KW - J 02400:Human Diseases KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709172856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Successful+Combination+of+Nucleic+Acid+Amplification+Test+Diagnostics+and+Targeted+Deferred+Neisseria+gonorrhoeae+Culture&rft.au=Wind%2C+Carolien+M%3Bde+Vries%2C+Henry+JC%3BSchim+van+der%2C+Maarten+F%3BUnemo%2C+Magnus%3Bvan+Dam%2C+Alje+P&rft.aulast=Wind&rft.aufirst=Carolien&rft.date=2015-06-01&rft.volume=53&rft.issue=6&rft.spage=1884&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00369-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 29 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Rectum; Data processing; nucleic acids; Drug resistance; Sampling; Infection; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1128/JCM.00369-15 ER - TY - JOUR T1 - Invited debate: Response to Capewell et al. AN - 1707500904 JF - Journal of Public Health AU - Greaves, Felix AU - Gresser, Charis AU - Kearney, Matt AU - Fenton, Kevin A AD - Waterall, Jamie; Address correspondence to Jamie Waterall, E-mail: Jamie.Waterall@phe.gov.uk Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 193 EP - 194 CY - Oxford PB - Oxford Publishing Limited(England) VL - 37 IS - 2 SN - 1741-3842 KW - Social Services And Welfare UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1707500904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Public+Health&rft.atitle=Invited+debate%3A+Response+to+Capewell+et+al.&rft.au=Waterall%2C+Jamie%3BGreaves%2C+Felix%3BGresser%2C+Charis%3BKearney%2C+Matt%3BFenton%2C+Kevin+A&rft.aulast=Waterall&rft.aufirst=Jamie&rft.date=2015-06-01&rft.volume=37&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Journal+of+Public+Health&rft.issn=17413842&rft_id=info:doi/10.1093%2Fpubmed%2Ffdv065 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-09-22 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.1093/pubmed/fdv065 ER - TY - JOUR T1 - The per case and total annual costs of foodborne illness in the United States AN - 1704340812; 4695064 AB - We present an economic welfare-based method to estimate the health costs associated with foodborne illness caused by known viruses, bacteria, parasites, allergens, two marine biotoxins, and unspecified agents. The method generates health costs measured in both quality-adjusted life years and in dollars. We calculate the reduction in quality-adjusted life days caused by the illness and add reductions in quality-adjusted life years from any secondary effects that are estimated to occur. For fatal cases, we calculate the life years lost due to premature death. We add direct medical expenses to the monetary costs as derived from estimates of willingness to pay to reduce health risks. In total, we estimate that foodborne illness represents an annual burden to society of approximately $36 billion, with an average identified illness estimated to reduce quality-adjusted life days by 0.84, which is monetized and included in the average cost burden per illness of $3,630. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Brown, Bradley AU - Nardinelli, Clark AU - Zorn, David AU - Minor, Travis AU - Lasher, Angela AU - Klontz, Karl AD - US Food and Drug Administration Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 1125 EP - 1139 VL - 35 IS - 6 SN - 0272-4332, 0272-4332 KW - Economics KW - Health expenditure KW - Welfare economics KW - U.S.A. KW - Willingness-to-pay KW - Illness KW - Adjustment costs KW - Quality of life UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1704340812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=The+per+case+and+total+annual+costs+of+foodborne+illness+in+the+United+States&rft.au=Brown%2C+Bradley%3BNardinelli%2C+Clark%3BZorn%2C+David%3BMinor%2C+Travis%3BLasher%2C+Angela%3BKlontz%2C+Karl&rft.aulast=Brown&rft.aufirst=Bradley&rft.date=2015-06-01&rft.volume=35&rft.issue=6&rft.spage=1125&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Frisa.12316 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-08-17 N1 - Last updated - 2015-08-17 N1 - SubjectsTermNotLitGenreText - 6220; 5780 4618; 10525 12162 3898; 13567 13219 13221; 564 2934; 13525 4019; 433 293 14 DO - http://dx.doi.org/10.1111/risa.12316 ER - TY - JOUR T1 - Seasonal Dynamics and Habitat Specificity of Mosquitoes in an English Wetland: Implications for UK Wetland Management and Restoration AN - 1701483629; PQ0001667249 AB - We engaged in field studies of native mosquitoes in a Cambridgeshire Fen, investigating a) the habitat specificity and seasonal dynamics of our native fauna in an intensively managed wetland, b) the impact of water-level and ditch management, and c) their colonization of an arable reversion to flooded grassland wetland expansion project. Studies from April to October, 2010 collected 14,000 adult mosquitoes (15 species) over 292 trap-nights and similar to 4,000 pre-imaginal mosquitoes (11 species). Open floodwater species (Aedes caspius and Aedes cinereus, 43.3%) and wet woodland species (Aedes cantans/annulipes and Aedes rusticus, 32.4%) dominated, highlighting the major impact of seasonal water-level management on mosquito populations in an intensively managed wetland. In permanent habitats, managing marginal ditch vegetation and ditch drying significantly affect densities of pre-imaginal anophelines and culicines, respectively. This study presents the first UK field evidence of the implications of wetland expansion through arable reversion on mosquito colonization. Understanding the heterogeneity of mosquito diversity, phenology, and abundance in intensively managed UK wetlands will be crucial to mitigating nuisance and vector species through habitat management and biocidal control. JF - Journal of Vector Ecology AU - Medlock, Jolyon M AU - Vaux, Alexander GC AD - Medical Entomology and Zoonoses Ecology Group, MRA, Emergency Response Department, Public Health England, Porton Down, Salisbury, United Kingdom, jolyon.medlock@phe.gov.uk Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 90 EP - 106 PB - Society for Vector Ecology VL - 40 IS - 1 SN - 1081-1710, 1081-1710 KW - Entomology Abstracts; Ecology Abstracts KW - Wetlands KW - ecology KW - mosquitoes KW - Anopheles KW - Aedes KW - Culex KW - Aedes rusticus KW - Abundance KW - Vectors KW - Reversion KW - Drying KW - Vegetation KW - Habitat KW - Colonization KW - Grasslands KW - Phenology KW - Aedes caspius KW - Aedes cinereus KW - Z 05340:Ecology and Behavior KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701483629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Vector+Ecology&rft.atitle=Seasonal+Dynamics+and+Habitat+Specificity+of+Mosquitoes+in+an+English+Wetland%3A+Implications+for+UK+Wetland+Management+and+Restoration&rft.au=Medlock%2C+Jolyon+M%3BVaux%2C+Alexander+GC&rft.aulast=Medlock&rft.aufirst=Jolyon&rft.date=2015-06-01&rft.volume=40&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=Journal+of+Vector+Ecology&rft.issn=10811710&rft_id=info:doi/10.1111%2Fjvec.12137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 43 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Grasslands; Colonization; Phenology; Abundance; Vegetation; Drying; Reversion; Vectors; Wetlands; Habitat; Aedes rusticus; Aedes; Aedes cinereus; Aedes caspius DO - http://dx.doi.org/10.1111/jvec.12137 ER - TY - JOUR T1 - Dose-response assessment of the dermal toxicity of triclosan in B6C3F1 mice AN - 1701482987; PQ0001703913 AB - Triclosan [5-chloro-2-(2,4-dichlorophenoxy)phenol] is a widely used antimicrobial agent in personal care products, household items, medical devices, and clinical settings. Due to its extensive use, there is potential for humans in all age groups to receive life-time exposures to triclosan, yet data on the chronic dermal toxicity/carcinogenicity of triclosan are still lacking. The present study evaluated the toxicity of triclosan administered dermally to B6C3F1 mice for 13 weeks. Groups of 10 male and 10 female B6C3F1 mice received dermal applications of 0, 5.8, 12.5, 27, 58, or 125 mg triclosan per kg body weight (bw) daily for 13 weeks. The doses were administered in 1 ml ethanol per kg bw. All mice survived the 13-week treatment period. Body weights of female mice receiving 125 mg triclosan per kg bw per day weighed 94% (p< 0.05) of the female control mice; male mice administered 58 and 125 mg triclosan per kg bw per day weighed 91% (p< 0.05) and 82% (p< 0.01) of the control male mice. Liver weights were significantly increased in females receiving 58 and 125 mg triclosan per kg bw per day and in males in the 125 mg triclosan per kg bw per day dose group. A significant dose-dependent decrease in the levels of thyroxine and cholesterol was observed in both sexes. The highest dose of triclosan increased the percentage of reticulocytes in both sexes; in addition, the 58 mg triclosan per kg bw per day dose increased the percentage of reticulocytes in females. Skin lesions (dermal fibrosis and inflammation; epidermal hyperplasia, inflammation, necrosis, and ulceration, and parakeratosis) were observed in both sexes, with a dose-dependent increase in severity and incidence. JF - Toxicology Research AU - Fang, Jia-Long AU - M Vanlandingham, Michelle AU - Juliar, Beth E AU - R Olson, Greg AU - E Patton, Ralph AU - Beland, Frederick A AD - Division of Biochemical Toxicology; National Center for Toxicological Research; Jefferson; Arkansas 72079; USA; +870-543-7136; +870-543-7612; , jia-long.fang@fda.hhs.gov Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 867 EP - 877 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 4 IS - 4 SN - 2045-452X, 2045-452X KW - Toxicology Abstracts KW - Age KW - Data processing KW - Skin KW - Fibrosis KW - Toxicity KW - Cholesterol KW - Inflammation KW - Antimicrobial agents KW - Hyperplasia KW - Necrosis KW - Body weight KW - Skin diseases KW - Carcinogenicity KW - Liver KW - Thyroxine KW - Reticulocytes KW - Triclosan KW - Ethanol KW - Sex KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701482987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Research&rft.atitle=Dose-response+assessment+of+the+dermal+toxicity+of+triclosan+in+B6C3F1+mice&rft.au=Fang%2C+Jia-Long%3BM+Vanlandingham%2C+Michelle%3BJuliar%2C+Beth+E%3BR+Olson%2C+Greg%3BE+Patton%2C+Ralph%3BBeland%2C+Frederick+A&rft.aulast=Fang&rft.aufirst=Jia-Long&rft.date=2015-06-01&rft.volume=4&rft.issue=4&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=Toxicology+Research&rft.issn=2045452X&rft_id=info:doi/10.1039%2Fc4tx00152d LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Number of references - 51 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Age; Skin; Data processing; Fibrosis; Cholesterol; Toxicity; Antimicrobial agents; Inflammation; Necrosis; Hyperplasia; Skin diseases; Body weight; Carcinogenicity; Thyroxine; Liver; Triclosan; Reticulocytes; Sex; Ethanol DO - http://dx.doi.org/10.1039/c4tx00152d ER - TY - JOUR T1 - Towards early inclusion of children in tuberculosis drugs trials: a consensus statement. AN - 1698956884; 25957923 AB - Children younger than 18 years account for a substantial proportion of patients with tuberculosis worldwide. Available treatments for paediatric drug-susceptible and drug-resistant tuberculosis, albeit generally effective, are hampered by high pill burden, long duration of treatment, coexistent toxic effects, and an overall scarcity of suitable child-friendly formulations. Several new drugs and regimens with promising activity against both drug-susceptible and drug-resistant strains have entered clinical development and are either in various phases of clinical investigation or have received marketing authorisation for adults; however, none have data on their use in children. This consensus statement, generated from an international panel of opinion leaders on childhood tuberculosis and incorporating reviews of published literature from January, 2004, to May, 2014, addressed four key questions: what drugs or regimens should be prioritised for clinical trials in children? Which populations of children are high priorities for study? When can phase 1 or 2 studies be initiated in children? What are the relevant elements of clinical trial design? The consensus panel found that children can be included in studies at the early phases of drug development and should be an integral part of the clinical development plan, rather than studied after regulatory approval in adults is obtained. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - The Lancet. Infectious diseases AU - Nachman, Sharon AU - Ahmed, Amina AU - Amanullah, Farhana AU - Becerra, Mercedes C AU - Botgros, Radu AU - Brigden, Grania AU - Browning, Renee AU - Gardiner, Elizabeth AU - Hafner, Richard AU - Hesseling, Anneke AU - How, Cleotilde AU - Jean-Philippe, Patrick AU - Lessem, Erica AU - Makhene, Mamodikoe AU - Mbelle, Nontombi AU - Marais, Ben AU - McIlleron, Helen AU - McNeeley, David F AU - Mendel, Carl AU - Murray, Stephen AU - Navarro, Eileen AU - Anyalechi, E Gloria AU - Porcalla, Ariel R AU - Powell, Clydette AU - Powell, Mair AU - Rigaud, Mona AU - Rouzier, Vanessa AU - Samson, Pearl AU - Schaaf, H Simon AU - Shah, Seema AU - Starke, Jeff AU - Swaminathan, Soumya AU - Wobudeya, Eric AU - Worrell, Carol AD - SUNY at Stony Brook, Stony Brook, NY, USA. Electronic address: sharon.nachman@stonybrook.edu. ; Levine Children's Hospital at Carolinas Medical Center, Charlotte, NC, USA. ; Indus Hospital, Pakistan. ; Harvard Medical School, Boston, MA, USA. ; European Medicines Agency, London, UK. ; Médecins Sans Frontières, Access Campaign, Geneva, Switzerland. ; National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of AIDS, Bethesda, MD, USA. ; TB Alliance, New York, NY, USA. ; Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa. ; Department of Pharmacology and Toxicology, University of the Philippines, Manila, Philippines. ; Henry M Jackson Foundation-Division of AIDS, Contractor to National Institutes of Health, National Institute of Allergy and Infectious Diseases, Department of Health and Human Services, Bethesda, MD, USA. ; Treatment Action Group, New York, NY, USA. ; Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa. ; Marie Bashir Institute for Infectious Diseases and Biosecurity and the Sydney Emerging Infectious Diseases and Biosecurity Institute and The Children's Hospital at Westmead, Sydney Medical School, University of Sydney, Sydney, Australia. ; Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, South Africa. ; Novartis Pharmaceuticals, East Hanover, NJ, USA. ; Division of Anti-Infective Products; Office of Antimicrobial Products, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. ; US Centers for Disease Control and Prevention, Division of Tuberculosis Elimination, International Research and Programs Branch, Atlanta, GA, USA. ; US Agency for International Development, Washington, DC, USA. ; New York University School of Medicine, NY, USA. ; GHESKIO, Port-au-Prince, Haiti. ; Statistical and Data Analysis Center, Center for Biostatistics in AIDS Research and Frontier Science, Harvard School of Public Health, Boston, MA, USA. ; Department of Bioethics, NIH Clinical Center, Bethesda, MD, USA. ; Baylor College of Medicine, Houston, TX, USA. ; National Institute for Research in Tuberculosis, Chennai, India. ; Makerere University Johns Hopkins Research Collaboration, and Mulago National Referral Hospital, Kampala, Uganda. ; Eunice Kennedy Schriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, MD, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 711 EP - 720 VL - 15 IS - 6 KW - Antitubercular Agents KW - 0 KW - Index Medicus KW - Infant KW - Age Factors KW - Humans KW - Adult KW - Infant, Newborn KW - Consensus KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Tuberculosis -- drug therapy KW - Clinical Trials as Topic KW - Antitubercular Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698956884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Lancet.+Infectious+diseases&rft.atitle=Towards+early+inclusion+of+children+in+tuberculosis+drugs+trials%3A+a+consensus+statement.&rft.au=Nachman%2C+Sharon%3BAhmed%2C+Amina%3BAmanullah%2C+Farhana%3BBecerra%2C+Mercedes+C%3BBotgros%2C+Radu%3BBrigden%2C+Grania%3BBrowning%2C+Renee%3BGardiner%2C+Elizabeth%3BHafner%2C+Richard%3BHesseling%2C+Anneke%3BHow%2C+Cleotilde%3BJean-Philippe%2C+Patrick%3BLessem%2C+Erica%3BMakhene%2C+Mamodikoe%3BMbelle%2C+Nontombi%3BMarais%2C+Ben%3BMcIlleron%2C+Helen%3BMcNeeley%2C+David+F%3BMendel%2C+Carl%3BMurray%2C+Stephen%3BNavarro%2C+Eileen%3BAnyalechi%2C+E+Gloria%3BPorcalla%2C+Ariel+R%3BPowell%2C+Clydette%3BPowell%2C+Mair%3BRigaud%2C+Mona%3BRouzier%2C+Vanessa%3BSamson%2C+Pearl%3BSchaaf%2C+H+Simon%3BShah%2C+Seema%3BStarke%2C+Jeff%3BSwaminathan%2C+Soumya%3BWobudeya%2C+Eric%3BWorrell%2C+Carol&rft.aulast=Nachman&rft.aufirst=Sharon&rft.date=2015-06-01&rft.volume=15&rft.issue=6&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=The+Lancet.+Infectious+diseases&rft.issn=1474-4457&rft_id=info:doi/10.1016%2FS1473-3099%2815%2900007-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-03 N1 - Date created - 2015-05-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2012 Nov 15;186(10):953-64 [22983960] Int J Tuberc Lung Dis. 2012 Dec;16(12):1588-93 [23032215] Pediatr Infect Dis J. 2013 Sep;32(9):972-7 [23503163] MMWR Recomm Rep. 2013 Oct 25;62(RR-09):1-12 [24157696] Int J Tuberc Lung Dis. 2013 Dec;17(12):1518-23 [24200262] BMC Infect Dis. 2013;13:392 [23977834] Clin Infect Dis. 2013 Dec;57(12):1676-84 [24065321] J Chemother. 2014 Feb;26(1):1-12 [24090489] Proc Am Thorac Soc. 2007 May;4(2):176-8, discussion 178-9 [17494727] Paediatr Respir Rev. 2007 Jun;8(2):142-7 [17574158] J Infect Dis. 2007 Aug 15;196 Suppl 1:S76-85 [17624829] PLoS Med. 2008 Aug 19;5(8):e176 [18715115] Clin Infect Dis. 2009 Jan 1;48(1):108-14 [19049436] Int J Tuberc Lung Dis. 2009 Jul;13(7):862-7 [19555536] Am J Public Health. 2009 Aug;99(8):1486-90 [19197080] Crit Care Med. 2009 Sep;37(9):2638-41 [19602971] Clin Chest Med. 2009 Dec;30(4):667-83, vii-viii [19925960] N Engl J Med. 2003 Sep 18;349(12):1157-67 [13679531] Eur J Pediatr. 2004 Feb;163(2):53-7 [14716559] Lancet Infect Dis. 2010 Nov;10(11):803-12 [20822958] J Clin Pharmacol. 2010 Dec;50(12):1377-87 [20150527] Paediatr Respir Rev. 2011 Mar;12(1):39-45 [21172674] Indian J Pediatr. 2011 Apr;78(4):456-63 [21193973] Arch Dis Child. 2011 Jun;96(6):560-4 [21310895] Scand J Infect Dis. 2011 Jul;43(6-7):556-9 [21391771] Int J Tuberc Lung Dis. 2011 Sep;15(9):1191-3, i [21943844] Pediatrics. 2011 Nov;128(5):e1242-9 [22025597] Antimicrob Agents Chemother. 2011 Dec;55(12):5560-7 [21968358] N Engl J Med. 2011 Dec 8;365(23):2155-66 [22150035] Int J Tuberc Lung Dis. 2012 Jan;16(1):76-81 [22236850] Int J Tuberc Lung Dis. 2012 Feb;16(2):196-202 [22236920] Tuberculosis (Edinb). 2012 Jan;92(1):9-17 [22118883] J Infect Dis. 2012 May 15;205 Suppl 2:S199-208 [22448023] Eur J Med Chem. 2012 May;51:1-16 [22421275] N Engl J Med. 2012 Jun 7;366(23):2151-60 [22670901] Pediatr Infect Dis J. 2012 Jul;31(7):711-6 [22411053] Int J Tuberc Lung Dis. 2012 Apr;16(4):447-54 [22325685] Clin Infect Dis. 2012 Aug;55(4):572-81 [22615332] N Engl J Med. 2012 Jul 26;367(4):348-61 [22830465] Pediatrics. 2012 Aug;130(2):e373-9 [22826566] Trop Med Int Health. 2012 Jan;17(1):52-8 [21967134] N Engl J Med. 2012 Oct 18;367(16):1508-18 [23075177] Eur Respir J. 2013 Sep;42(3):701-7 [23222872] Expert Opin Investig Drugs. 2013 Jul;22(7):927-32 [23687915] Clin Dev Immunol. 2013;2013:781320 [23762096] Eur Respir J. 2013 Jun;41(6):1393-400 [23018916] Int J Tuberc Lung Dis. 2013 Jun;17(6):794-9 [23676164] Nat Rev Drug Discov. 2013 May;12(5):388-404 [23629506] Int J Tuberc Lung Dis. 2013 May;17(5):624-9 [23575328] Lancet Infect Dis. 2013 Apr;13(4):287-9 [23531386] J Infect. 2013 Apr;66(4):320-9 [22960077] J Infect Dis. 2012 Dec 15;206(12):1809-15 [23033147] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/S1473-3099(15)00007-9 ER - TY - JOUR T1 - Long-Term Care Financing: Lessons From France AN - 1698884079 AB - Context An aging population leads to a growing demand for long-term services and supports (LTSS). In 2002, France introduced universal, income-adjusted, public long-term care coverage for adults 60 and older, whereas the United States funds means-tested benefits only. Both countries have private long-term care insurance (LTCI) markets: American policies create alternatives to out-of-pocket spending and protect purchasers from relying on Medicaid. Sales, however, have stagnated, and the marketʼs viability is uncertain. In France, private LTCI supplements public coverage, and sales are growing, although its potential to alleviate the long-term care financing problem is unclear. We explore whether Franceʼs very different approach to structuring public and private financing for long-term care could inform the United States’ long-term care financing reform efforts. Methods We consulted insurance experts and conducted a detailed review of public reports, academic studies, and other documents to understand the public and private LTCI systems in France, their advantages and disadvantages, and the factors affecting their development. Findings France provides universal public coverage for paid assistance with functional dependency for people 60 and older. Benefits are steeply income adjusted and amounts are low. Nevertheless, expenditures have exceeded projections, burdening local governments. Private supplemental insurance covers 11% of French, mostly middle-income adults (versus 3% of Americans 18 and older). Whether policyholders will maintain employer-sponsored coverage after retirement is not known. The governmentʼs interest in pursuing an explicit public/private partnership has waned under President François Hollande, a centrist socialist, in contrast to the previous center-right leader, President Nicolas Sarkozy, thereby reducing the prospects of a coordinated public/private strategy. Conclusions American private insurers are showing increasing interest in long-term care financing approaches that combine public and private elements. The French example shows how a simple, cheap, cash-based product can gain traction among middle-income individuals when offered by employers and combined with a steeply income-adjusted universal public program. The adequacy of such coverage, however, is a concern. JF - The Milbank Quarterly AU - DOTY, PAMELA AU - NADASH, PAMELA AU - RACCO, NATHALIE AD - US Department of Health and Human Services. ; McCormack Graduate School of Policy and Global Studies, University of Massachusetts Boston. ; Swiss Reinsurance Company Ltd. ; US Department of Health and Human Services. Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 359 EP - 391 CY - Oxford PB - Wiley Subscription Services, Inc. VL - 93 IS - 2 SN - 0887-378X KW - Political Science KW - Elderly KW - Adults KW - Markets KW - Financial Support KW - Services KW - Dietary Supplements KW - Reform KW - Employers KW - Expenditures KW - Experts KW - Public Finance KW - Medicaid KW - Population Aging KW - Presidents KW - Retirement KW - Sales KW - Long term care KW - Personal expenditure KW - Projections KW - Prospects KW - Support services KW - Traction KW - Viability KW - Aging KW - Development Strategies KW - Income KW - Long Term Care KW - Ageing KW - Buyers KW - Coverage KW - Dependency KW - Expenditure KW - Financing KW - Funds KW - Health insurance KW - Insurance KW - France KW - Sarkozy, Nicolas KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1698884079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Milbank+Quarterly&rft.atitle=Long-Term+Care+Financing%3A+Lessons+From+France&rft.au=DOTY%2C+PAMELA%3BNADASH%2C+PAMELA%3BRACCO%2C+NATHALIE&rft.aulast=DOTY&rft.aufirst=PAMELA&rft.date=2015-06-01&rft.volume=93&rft.issue=2&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=The+Milbank+Quarterly&rft.issn=0887378X&rft_id=info:doi/10.1111%2F1468-0009.12125 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Date revised - 2015-07-07 N1 - People - Sarkozy, Nicolas N1 - Last updated - 2016-06-07 N1 - SubjectsTermNotLitGenreText - Sarkozy, Nicolas; France; United States--US DO - http://dx.doi.org/10.1111/1468-0009.12125 ER - TY - JOUR T1 - Acrylamide-induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks AN - 1694974463; PQ0001664186 AB - Potential health risks for humans from exposure to acrylamide (AA) and its epoxide metabolite glycidamide (GA) have garnered much attention lately because substantial amounts of AA are present in a variety of fried and baked starchy foods. AA is tumorigenic in rodents, and a large number of in vitro and in vivo studies indicate that AA is genotoxic. A recent cancer bioassay on AA demonstrated that the lung was one of the target organs for tumor induction in mice; however, the mutagenicity of AA in this tissue is unclear. Therefore, to investigate whether or not gene mutation is involved in the etiology of AA- or GA-induced mouse lung carcinogenicity, we screened for cII mutant frequency (MF) in lungs from male and female Big Blue (BB) mice administered 0, 1.4, and 7.0 mM AA or GA in drinking water for up to 4 weeks (19-111 mg/kg bw/days). Both doses of AA and GA produced significant increases in cII MFs, with the high doses producing responses 2.7-5.6-fold higher than the corresponding controls (P less than or equal to 0.05; control MFs=17.2 plus or minus 2.2 and 15.8 plus or minus 3.5 x 10 super(-6) in males and females, respectively). Molecular analysis of the mutants from high doses indicated that AA and GA produced similar mutation spectra and that these spectra were significantly different from the spectra in control mice (P less than or equal to 0.01). The predominant types of mutations in the lung cII gene from AA- and GA-treated mice were A:T arrow right T:A, and G:C arrow right C:G transversions, and -1/+1 frameshifts at a homopolymeric run of Gs. The MFs and types of mutations induced by AA and GA in the lung are consistent with AA exerting its genotoxicity via metabolism to GA. These results suggest that AA is a mutagenic carcinogen in mouse lungs and therefore further studies on its potential health risk to humans are warranted. Environ. Mol. Mutagen. 56:446-456, 2015. JF - Environmental and Molecular Mutagenesis AU - Manjanatha, Mugimane G AU - Guo, Li-Wu AU - Shelton, Sharon D AU - Doerge, Daniel R AD - Division of Genetic and Molecular Toxicology, US FDA, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 446 EP - 456 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 56 IS - 5 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Genetics Abstracts KW - Mutagens KW - Epoxides KW - Food KW - Metabolites KW - Mutant frequency KW - Carcinogens KW - Transversion KW - Mutants KW - Mutagenesis KW - Carcinogenicity KW - Mutagenicity KW - Etiology KW - Genotoxicity KW - Point mutation KW - Mice KW - Tumors KW - Cancer KW - Health risks KW - Bioassays KW - Acrylamide KW - Lung KW - Drinking water KW - Mutation KW - Metabolism KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694974463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Acrylamide-induced+carcinogenicity+in+mouse+lung+involves+mutagenicity%3A+cII+gene+mutations+in+the+lung+of+big+blue+mice+exposed+to+acrylamide+and+glycidamide+for+up+to+4+weeks&rft.au=Manjanatha%2C+Mugimane+G%3BGuo%2C+Li-Wu%3BShelton%2C+Sharon+D%3BDoerge%2C+Daniel+R&rft.aulast=Manjanatha&rft.aufirst=Mugimane&rft.date=2015-06-01&rft.volume=56&rft.issue=5&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.21939 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Mutagens; Etiology; Mutagenicity; Epoxides; Food; Point mutation; Genotoxicity; Mutant frequency; Metabolites; Carcinogens; Tumors; Cancer; Transversion; Mutagenesis; Acrylamide; Lung; Carcinogenicity; Drinking water; Metabolism; Mice; Mutants; Health risks; Bioassays; Mutation DO - http://dx.doi.org/10.1002/em.21939 ER - TY - JOUR T1 - Data Mining FAERS to Analyze Molecular Targets of Drugs Highly Associated with Stevens-Johnson Syndrome. AN - 1689843805; 25876064 AB - Drug features that are associated with Stevens-Johnson syndrome (SJS) have not been fully characterized. A molecular target analysis of the drugs associated with SJS in the FDA Adverse Event Reporting System (FAERS) may contribute to mechanistic insights into SJS pathophysiology. The publicly available version of FAERS was analyzed to identify disproportionality among the molecular targets, metabolizing enzymes, and transporters for drugs associated with SJS. The FAERS in-house version was also analyzed for an internal comparison of the drugs most highly associated with SJS. Cyclooxygenases 1 and 2, carbonic anhydrase 2, and sodium channel 2 alpha were identified as disproportionately associated with SJS. Cytochrome P450 (CYPs) 3A4 and 2C9 are disproportionately represented as metabolizing enzymes of the drugs associated with SJS adverse event reports. Multidrug resistance protein 1 (MRP-1), organic anion transporter 1 (OAT1), and PEPT2 were also identified and are highly associated with the transport of these drugs. A detailed review of the molecular targets identifies important roles for these targets in immune response. The association with CYP metabolizing enzymes suggests that reactive metabolites and oxidative stress may have a contributory role. Drug transporters may enhance intracellular tissue concentrations and also have vital physiologic roles that impact keratinocyte proliferation and survival. Data mining FAERS may be used to hypothesize mechanisms for adverse drug events by identifying molecular targets that are highly associated with drug-induced adverse events. The information gained may contribute to systems biology disease models. JF - Journal of medical toxicology : official journal of the American College of Medical Toxicology AU - Burkhart, Keith K AU - Abernethy, Darrell AU - Jackson, David AD - Medical Informatics Team, Office of Clinical Pharmacology, Office of Translational Science, Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, Bldg 64, Rm 2012, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA, keith.burkhart@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 265 EP - 273 VL - 11 IS - 2 KW - Carrier Proteins KW - 0 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - United States KW - Cell Proliferation -- drug effects KW - Software KW - United States Food and Drug Administration KW - Cytochrome P-450 Enzyme System -- genetics KW - Keratinocytes -- drug effects KW - Humans KW - Carrier Proteins -- genetics KW - Incidence KW - Cytochrome P-450 Enzyme System -- metabolism KW - Structure-Activity Relationship KW - Genes, MHC Class II KW - Stevens-Johnson Syndrome -- therapy KW - Stevens-Johnson Syndrome -- epidemiology KW - Adverse Drug Reaction Reporting Systems KW - Data Mining -- methods KW - Stevens-Johnson Syndrome -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1689843805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.atitle=Data+Mining+FAERS+to+Analyze+Molecular+Targets+of+Drugs+Highly+Associated+with+Stevens-Johnson+Syndrome.&rft.au=Burkhart%2C+Keith+K%3BAbernethy%2C+Darrell%3BJackson%2C+David&rft.aulast=Burkhart&rft.aufirst=Keith&rft.date=2015-06-01&rft.volume=11&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+toxicology+%3A+official+journal+of+the+American+College+of+Medical+Toxicology&rft.issn=1937-6995&rft_id=info:doi/10.1007%2Fs13181-015-0472-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-22 N1 - Date created - 2015-06-17 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Pharm Pharmacol. 2008 May;60(5):543-85 [18416933] Bioorg Med Chem. 2008 Aug 1;16(15):7424-8 [18579385] J Pharm Biomed Anal. 2008 Sep 10;48(1):92-9 [18584988] Pain. 2008 Sep 30;139(1):90-105 [18442883] Am J Respir Cell Mol Biol. 2008 Nov;39(5):536-42 [18474668] J Chromatogr A. 2008 Oct 24;1208(1-2):164-74 [18778828] Drug Metab Dispos. 2009 Feb;37(2):247-53 [19005027] Xenobiotica. 2009 Jan;39(1):11-21 [19219744] Pharm Res. 2009 Apr;26(4):822-35 [19082874] Regul Toxicol Pharmacol. 2009 Jun;54(1):1-22 [19422096] Curr Opin Allergy Clin Immunol. 2009 Aug;9(4):311-5 [19535973] Expert Opin Drug Metab Toxicol. 2009 Aug;5(8):887-905 [19519280] Nature. 2009 Nov 12;462(7270):175-81 [19881490] Chem Res Toxicol. 2010 Jan;23(1):159-70 [19961160] Am J Health Syst Pharm. 2010 Feb 1;67(3):206-13 [20101062] Rapid Commun Mass Spectrom. 2010 May 30;24(10):1447-56 [20411584] Drug Metab Dispos. 2010 Jun;38(6):923-9 [20304965] J Pharmacol Exp Ther. 2010 Aug;334(2):609-18 [20484152] Br J Pharmacol. 2010 Sep;161(1):229-40 [20718752] Allergol Int. 2010 Dec;59(4):325-32 [20962567] Orphanet J Rare Dis. 2010;5:39 [21162721] Br J Dermatol. 2010 Jun;162(6):1302-15 [20128793] J Allergy Clin Immunol. 2011 Mar;127(3 Suppl):S74-81 [21354503] Yakugaku Zasshi. 2011;131(5):809-15 [21532277] Drug Metab Dispos. 2011 Jun;39(6):1014-21 [21383205] Am J Reprod Immunol. 2011 Oct;66(4):297-303 [21244564] Biochem Soc Trans. 2011 Oct;39(5):1353-8 [21936814] Clin Pharmacol Ther. 2011 Nov;90(5):662-5 [21975349] Ann Rheum Dis. 2012 Jan;71(1):20-5 [22039164] Arch Dermatol Res. 2012 Jan;304(1):57-63 [21922333] Annu Rev Pharmacol Toxicol. 2012;52:401-31 [22017685] J Allergy Clin Immunol. 2012 Jun;129(6):1562-9.e5 [22322005] AIDS. 2012 Jul 17;26(11):F21-9 [22617051] J Enzyme Inhib Med Chem. 2012 Oct;27(5):641-5 [21851212] Am J Respir Cell Mol Biol. 2013 Feb;48(2):230-9 [23239496] J Cell Sci. 2013 May 1;126(Pt 9):1942-51 [23447677] Pharmacol Res. 2000 Aug;42(2):187-191 [10887051] Eur J Clin Pharmacol. 2002 Apr;58(1):69-72 [11956677] Pharmacoepidemiol Drug Saf. 2002 Jan-Feb;11(1):3-10 [11998548] Int J Colorectal Dis. 2002 Sep;17(5):317-26 [12172925] Life Sci. 2003 Apr 25;72(23):2581-90 [12672504] Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42 [12920490] Eur J Dermatol. 2003 Sep-Oct;13(5):440-4 [14693486] J Rheumatol. 2004 Mar;31(3):436-41 [14994385] Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):402-9 [6528810] Arzneimittelforschung. 1986 Sep;36(9):1417-20 [3790196] Xenobiotica. 1991 Oct;21(10):1281-8 [1686692] J Chromatogr. 1993 Jun 23;616(1):79-85 [7690764] J Biol Chem. 1995 Sep 1;270(35):20668-76 [7657646] Clin Pharmacokinet. 1998 Dec;35(6):425-36 [9884815] Mol Pharmacol. 1999 May;55(5):847-54 [10220563] J Cell Sci. 1999 Oct;112 ( Pt 19):3343-52 [10504339] J Pharmacol Exp Ther. 2004 Dec;311(3):1131-7 [15292462] Drug Saf. 2005;28(10):917-24 [16180941] Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15247-52 [16217040] Am J Physiol Renal Physiol. 2006 Feb;290(2):F251-61 [16403838] Pharmacogenet Genomics. 2006 Apr;16(4):297-306 [16538176] Ther Drug Monit. 2007 Feb;29(1):118-21 [17304159] J Biochem. 2007 Mar;141(3):429-41 [17298961] Blood. 2007 Apr 15;109(8):3608-9 [17409346] J Invest Dermatol. 2007 May;127(5):1145-53 [17124504] Drug Metab Pharmacokinet. 2007 Apr;22(2):103-12 [17495417] Curr Top Med Chem. 2007;7(9):885-91 [17504133] J Invest Dermatol. 2007 Jul;127(7):1786-9 [17363915] J Pharmacol Exp Ther. 2007 Sep;322(3):1208-20 [17556636] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s13181-015-0472-1 ER - TY - JOUR T1 - A review of nonoccupational pathways for pesticide exposure in women living in agricultural areas. AN - 1685752215; 25636067 AB - Women living in agricultural areas may experience high pesticide exposures compared with women in urban or suburban areas because of their proximity to farm activities. Our objective was to review the evidence in the published literature for the contribution of nonoccupational pathways of pesticide exposure in women living in North American agricultural areas. We evaluated the following nonoccupational exposure pathways: paraoccupational (i.e., take-home or bystander exposure), agricultural drift, residential pesticide use, and dietary ingestion. We also evaluated the role of hygiene factors (e.g., house cleaning, shoe removal). Among 35 publications identified (published 1995-2013), several reported significant or suggestive (p < 0.1) associations between paraoccupational (n = 19) and agricultural drift (n = 10) pathways and pesticide dust or biomarker levels, and 3 observed that residential use was associated with pesticide concentrations in dust. The 4 studies related to ingestion reported low detection rates of most pesticides in water; additional studies are needed to draw conclusions about the importance of this pathway. Hygiene factors were not consistently linked to exposure among the 18 relevant publications identified. Evidence supported the importance of paraoccupational, drift, and residential use pathways. Disentangling exposure pathways was difficult because agricultural populations are concurrently exposed to pesticides via multiple pathways. Most evidence was based on measurements of pesticides in residential dust, which are applicable to any household member and are not specific to women. An improved understanding of nonoccupational pesticide exposure pathways in women living in agricultural areas is critical for studying health effects in women and for designing effective exposure-reduction strategies. JF - Environmental health perspectives AU - Deziel, Nicole C AU - Friesen, Melissa C AU - Hoppin, Jane A AU - Hines, Cynthia J AU - Thomas, Kent AU - Freeman, Laura E Beane AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 515 EP - 524 VL - 123 IS - 6 KW - Environmental Pollutants KW - 0 KW - Pesticides KW - Index Medicus KW - Agriculture KW - North America KW - Humans KW - Female KW - Pesticides -- metabolism KW - Environmental Pollutants -- metabolism KW - Environmental Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1685752215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=A+review+of+nonoccupational+pathways+for+pesticide+exposure+in+women+living+in+agricultural+areas.&rft.au=Deziel%2C+Nicole+C%3BFriesen%2C+Melissa+C%3BHoppin%2C+Jane+A%3BHines%2C+Cynthia+J%3BThomas%2C+Kent%3BFreeman%2C+Laura+E+Beane&rft.aulast=Deziel&rft.aufirst=Nicole&rft.date=2015-06-01&rft.volume=123&rft.issue=6&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408273 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-24 N1 - Date created - 2015-06-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2010 Oct;118(10):1355-62 [20562050] Environ Health Perspect. 2011 Jul;119(7):970-6 [21330232] J Toxicol Environ Health A. 2005 Aug 13;68(15):1359-70 [16020195] Rev Environ Health. 2005 Apr-Jun;20(2):77-101 [16121832] Environ Health Perspect. 2005 Dec;113(12):1802-7 [16330368] J Occup Environ Med. 2011 Aug;53(8):884-91 [21775902] J Environ Qual. 2012 Mar-Apr;41(2):479-94 [22370411] J Occup Environ Hyg. 2012;9(5):289-97 [22506545] Environ Res. 2012 Aug;117:8-16 [22683313] J Occup Environ Med. 2012 Sep;54(9):1163-9 [22772953] Arch Environ Contam Toxicol. 2001 Jul;41(1):112-6 [11385597] Environ Res. 2000 Nov;84(3):290-302 [11097803] Environ Health Perspect. 2013 May;121(5):565-71 [23462689] Environ Health Perspect. 2001 May;109(5):533-8 [11401767] Environ Health Perspect. 2002 May;110(5):549-53 [12003762] J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Oct 5;778(1-2):5-29 [12376114] Environ Health Perspect. 2002 Dec;110(12):A787-92 [12460819] J Toxicol Environ Health A. 2003 Jan 24;66(2):103-32 [12653018] AAOHN J. 2003 Mar;51(3):113-9 [12670098] Environ Health Perspect. 2004 Feb;112(2):142-7 [14754567] Environ Health Perspect. 2004 Mar;112(3):321-6 [14998747] Environ Health Perspect. 2004 Mar;112(3):382-7 [14998757] Am J Ind Med. 2004 Jun;45(6):491-9 [15164393] Environ Res. 2004 Nov;96(3):283-9 [15364595] Arch Environ Contam Toxicol. 1994 Jan;26(1):37-46 [8110022] J Occup Med. 1994 Nov;36(11):1240-6 [7861269] Environ Health Perspect. 1995 Dec;103(12):1126-34 [8747019] J Expo Anal Environ Epidemiol. 1997 Jan-Mar;7(1):61-80 [9076610] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] Am J Ind Med. 1998 Dec;34(6):581-7 [9816416] J Expo Anal Environ Epidemiol. 2004 Nov;14(6):473-8 [15026777] J Occup Environ Hyg. 2005 Jul;2(7):357-67 [16020099] J Expo Sci Environ Epidemiol. 2006 Jan;16(1):98-104 [16015277] Environ Health Perspect. 2006 Jun;114(6):893-7 [16759991] Environ Health Perspect. 2006 Jul;114(7):999-1006 [16835050] J Expo Sci Environ Epidemiol. 2006 Sep;16(5):447-56 [16570094] J Expo Sci Environ Epidemiol. 2006 Sep;16(5):387-96 [16249796] J Agromedicine. 2006;11(2):81-8 [17135145] Ann Occup Hyg. 2007 Jan;51(1):53-65 [16984946] Environ Health Perspect. 2007 Mar;115(3):370-6 [17431485] Environ Sci Technol. 2007 May 15;41(10):3408-14 [17547156] J Expo Sci Environ Epidemiol. 2007 Jul;17(4):388-99 [17033681] Hum Reprod Update. 2008 Jan-Feb;14(1):59-72 [18070835] Environ Health Perspect. 2008 May;116(5):687-94 [18470300] Radiat Prot Dosimetry. 2008;132(2):148-55 [18930927] Environ Sci Technol. 2009 Dec 1;43(23):8767-74 [19943644] Environ Health Perspect. 2010 Jun;118(6):856-63 [20129873] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408273 ER - TY - JOUR T1 - Bioreactor Process Parameter Screening Utilizing a Plackett-Burman Design for a Model Monoclonal Antibody AN - 1683350675; PQ0001587256 AB - Consistent high-quality antibody yield is a key goal for cell culture bioprocessing. This endpoint is typically achieved in commercial settings through product and process engineering of bioreactor parameters during development. When the process is complex and not optimized, small changes in composition and control may yield a finished product of less desirable quality. Therefore, changes proposed to currently validated processes usually require justification and are reported to the US FDA for approval. Recently, design-of-experiments-based approaches have been explored to rapidly and efficiently achieve this goal of optimized yield with a better understanding of product and process variables that affect a product's critical quality attributes. Here, we present a laboratory-scale model culture where we apply a Plackett-Burman screening design to parallel cultures to study the main effects of 11 process variables. This exercise allowed us to determine the relative importance of these variables and identify the most important factors to be further optimized in order to control both desirable and undesirable glycan profiles. We found engineering changes relating to culture temperature and nonessential amino acid supplementation significantly impacted glycan profiles associated with fucosylation, beta -galactosylation, and sialylation. All of these are important for monoclonal antibody product quality. J Pharm Sci 104:1919-1928, 2015 JF - Journal of Pharmaceutical Sciences AU - Agarabi, Cyrus D AU - Schiel, John E AU - Lute, Scott C AU - Chavez, Brittany K AU - Boyne, Michael T AU - Brorson, Kurt A AU - Khan, Mansoor A AU - Read, Erik K AD - Division of Product Quality Research, Office of Testing and Research, OPS, CDER, FDA, Silver Spring, Maryland. Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 1919 EP - 1928 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 6 SN - 0022-3549, 0022-3549 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Amino acids KW - Monoclonal antibodies KW - Bioreactors KW - Process engineering KW - Cell culture KW - Polysaccharides KW - Supplementation KW - Physical training KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683350675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Bioreactor+Process+Parameter+Screening+Utilizing+a+Plackett-Burman+Design+for+a+Model+Monoclonal+Antibody&rft.au=Agarabi%2C+Cyrus+D%3BSchiel%2C+John+E%3BLute%2C+Scott+C%3BChavez%2C+Brittany+K%3BBoyne%2C+Michael+T%3BBrorson%2C+Kurt+A%3BKhan%2C+Mansoor+A%3BRead%2C+Erik+K&rft.aulast=Agarabi&rft.aufirst=Cyrus&rft.date=2015-06-01&rft.volume=104&rft.issue=6&rft.spage=1919&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24420 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Temperature effects; Amino acids; Monoclonal antibodies; Process engineering; Bioreactors; Cell culture; Polysaccharides; Supplementation; Physical training DO - http://dx.doi.org/10.1002/jps.24420 ER - TY - JOUR T1 - The impact of extended closing times of alcohol outlets on alcohol-related injuries in the nightlife areas of Amsterdam: a controlled before-and-after evaluation AN - 1683081951; 4675739 AB - The municipality of Amsterdam implemented a new alcohol policy allowing alcohol outlets in two of the five nightlife areas to extend their closing times from 1 April 2009 onwards. We investigated how levels and trends of alcohol-related injuries changed after implementation of this alcohol policy, by comparing areas with extended closing times to those without. A controlled before-and-after evaluation to compare changes in alcohol-related injuries between intervention and control areas. Central district of Amsterdam, The Netherlands. Alcohol-related ambulance attendances for control and intervention areas between 1 April 2006 and 1 April 2009 (respectively, n=544 and n=499) and between 1 April 2009 and 1 April 2011 (respectively, n  ;=357 and n=480). Alcohol-related injuries were defined as ambulance attendances for people who suffered from direct or indirect consequences of alcohol consumption. Injuries were counted per month in two intervention and three control nightlife areas. We used Poisson regression to assess changes in injuries. After 1 April 2009, intervention areas showed a larger change in the level of alcohol-related injuries than control areas [incidence rate ratio 1.34, 95% confidence interval (CI)=1.12, 1.61], but trends remained stable in all areas. This increase was only statistically significant for the following subgroups: 2.00-5.59  ;a.m., weekend days, men, individuals aged 25-34 years, and people transported to a hospital. However, the increase did not differ between subgroups with statistical significance. A 1-hour extension of alcohol outlet closing times in some of Amsterdam's nightlife areas was associated with 34% more alcohol-related injuries. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Kunst, Anton E AU - Goeij, Moniek C.M. De AU - Veldhuizen, Eleonore M AU - Buster, Marcel C.A. AD - University of Amsterdam ; Public Health Service of Amsterdam Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 955 EP - 964 VL - 110 IS - 6 SN - 0965-2140, 0965-2140 KW - Economics KW - Alcohol KW - Injuries KW - Alcoholism KW - Regression analysis KW - Netherlands KW - Drugs KW - Hospitals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683081951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+impact+of+extended+closing+times+of+alcohol+outlets+on+alcohol-related+injuries+in+the+nightlife+areas+of+Amsterdam%3A+a+controlled+before-and-after+evaluation&rft.au=Kunst%2C+Anton+E%3BGoeij%2C+Moniek+C.M.+De%3BVeldhuizen%2C+Eleonore+M%3BBuster%2C+Marcel+C.A.&rft.aulast=Kunst&rft.aufirst=Anton&rft.date=2015-06-01&rft.volume=110&rft.issue=6&rft.spage=955&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12886 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-05-26 N1 - Last updated - 2015-05-26 N1 - SubjectsTermNotLitGenreText - 913 561 6220; 6555 6220; 909; 10739 12228 10919; 3755; 6013 6590; 275 462 129 DO - http://dx.doi.org/10.1111/add.12886 ER - TY - JOUR T1 - Hepatitis C virus treatment as prevention among injecting drug users: who should we cure first? AN - 1683081789; 4675741 AB - Treatment of injecting drug users (IDU) for hepatitis C virus (HCV) infection may prevent onward transmission. Treating individuals who often share injecting equipment is most likely to prevent new infections. However, these high-risk IDU are also more likely to become re-infected than low-risk IDU. We investigated to which group treatment is best targeted. We modelled the expected benefits per treatment of one chronically HCV‐ ;infected IDU in a population of low- and high-risk IDU. The benefits of treating one low- or one high-risk IDU were compared. Benefits included the probability for the treated IDU to become and remain uninfected, as well as the expected number of prevented infections to others (i.e. we quantified the total expected decrease in chronic infections). We found a threshold in HCV-RNA prevalence above which treating low-risk IDU, and below which treating high-risk IDU, resulted in the greatest benefits. This threshold was at 50% of exchanged syringes being HCV contaminated. When 42% of IDU engaged in high-risk behaviour (borrowing and lending out syringes 7.3 times more frequently than low-risk IDU), the corresponding threshold of HCV-RNA prevalence among IDU was at 32%. Larger-risk heterogeneity led to a lower corresponding threshold among IDU. A combination of HCV treatment and 50% risk reduction was best directed at high-risk IDU for prevalence among syringes up to 59%. The threshold was marginally sensitive to changes in disease and treatment variables. When more than half of all exchanged syringes in a population of injecting drug users (IDU) are contaminated by hepatitis C virus, it is most efficient to treat low-risk IDU first. Below this threshold, it is most efficient to treat high-risk IDU first. Reprinted by permission of Blackwell Publishing JF - Addiction AU - de Vos, Anneke S AU - Prins, Maria AU - Kretzschmar, Mirjam E.E. AD - University Medical Center Utrecht ; Public Health Service of Amsterdam ; University of Amsterdam Y1 - 2015/06// PY - 2015 DA - Jun 2015 SP - 975 EP - 983 VL - 110 IS - 6 SN - 0965-2140, 0965-2140 KW - Sociology KW - Hepatitis KW - Prevention KW - Drug users KW - Medical treatment KW - Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683081789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Hepatitis+C+virus+treatment+as+prevention+among+injecting+drug+users%3A+who+should+we+cure+first%3F&rft.au=de+Vos%2C+Anneke+S%3BPrins%2C+Maria%3BKretzschmar%2C+Mirjam+E.E.&rft.aulast=de+Vos&rft.aufirst=Anneke&rft.date=2015-06-01&rft.volume=110&rft.issue=6&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fadd.12842 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-05-26 N1 - Last updated - 2015-05-26 N1 - SubjectsTermNotLitGenreText - 5810 3617 6220; 3754 3755; 7890 5792 10484; 10072; 3617 6220 DO - http://dx.doi.org/10.1111/add.12842 ER - TY - JOUR T1 - Elucidating the links between endocrine disruptors and neurodevelopment. AN - 1681912233; 25714811 AB - Recent data indicate that approximately 12% of children in the United States are affected by neurodevelopmental disorders, including attention deficit hyperactivity disorder, learning disorders, intellectual disabilities, and autism spectrum disorders. Accumulating evidence indicates a multifactorial etiology for these disorders, with social, physical, genetic susceptibility, nutritional factors, and chemical toxicants acting together to influence risk. Exposure to endocrine-disrupting chemicals during the early stages of life can disrupt normal patterns of development and thus alter brain function and disease susceptibility later in life. This article highlights research efforts and pinpoints approaches that could shed light on the possible associations between environmental chemicals that act on the endocrine system and compromised neurodevelopmental outcomes. JF - Endocrinology AU - Schug, Thaddeus T AU - Blawas, Ashley M AU - Gray, Kimberly AU - Heindel, Jerrold J AU - Lawler, Cindy P AD - Division of Extramural Research and Training (T.T.S., K.G., J.J.H., C.P.L.), National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709; and Duke University (A.M.B.), Durham, North Carolina 27708. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 1941 EP - 1951 VL - 156 IS - 6 KW - Benzhydryl Compounds KW - 0 KW - Endocrine Disruptors KW - Metals, Heavy KW - Pesticides KW - Phenols KW - DDT KW - CIW5S16655 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - bisphenol A KW - MLT3645I99 KW - Abridged Index Medicus KW - Index Medicus KW - Benzhydryl Compounds -- toxicity KW - Disease Susceptibility KW - Polychlorinated Biphenyls -- toxicity KW - Humans KW - DDT -- toxicity KW - Phenols -- toxicity KW - Endocrine System -- drug effects KW - Metals, Heavy -- toxicity KW - Pesticides -- toxicity KW - Endocrine Disruptors -- toxicity KW - Nervous System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1681912233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Elucidating+the+links+between+endocrine+disruptors+and+neurodevelopment.&rft.au=Schug%2C+Thaddeus+T%3BBlawas%2C+Ashley+M%3BGray%2C+Kimberly%3BHeindel%2C+Jerrold+J%3BLawler%2C+Cindy+P&rft.aulast=Schug&rft.aufirst=Thaddeus&rft.date=2015-06-01&rft.volume=156&rft.issue=6&rft.spage=1941&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=1945-7170&rft_id=info:doi/10.1210%2Fen.2014-1734 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-19 N1 - Date created - 2015-05-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1210/en.2014-1734 ER - TY - JOUR T1 - Survival and susceptibility of Burkholderia cepacia complex in chlorhexidine gluconate and benzalkonium chloride. AN - 1680955997; 25794566 AB - The Burkholderia cepacia complex (BCC) includes opportunistic pathogenic bacteria that have occasionally been recovered from various pharmaceutical products, including antiseptics and disinfectants. Plausible reasons for the contamination include intrinsic sources, such as inadequate process controls, especially for water or equipment used during product manufacture, or extrinsic sources, such as improper handling and dilution or distribution in contaminated containers. Because the survival of BCC in antiseptics is a concern to the public health and pharmaceutical industry, we determined minimum inhibitory concentrations (MICs) of 36 BCC strains against the antiseptics, following exposure to chlorhexidine gluconate (CHX) and benzalkonium chloride (BZK) solutions (1-500 µg/ml for each chemical). Susceptibility to CHX and BZK varied across the BCC strains and was recorded as mean 90.3 and 111.1 µg/ml, respectively, at initial inoculation, which was significantly higher than the 46.4 and 61.1 µg/ml levels measured for BCC incubated in water for 40 days. After determining antiseptic MICs of individual BCC strains, BCC recovery was measured on Tryptic Soy Agar (TSA), Reasoner's Second Agar (R2A) and diluted preparations of these media under their sub-MICs. The survival of BCC was monitored for 14 days (336 h) in sub-MICs diluted to less than their antiseptic susceptible concentration value. Diluted TSA and R2A media exhibited greater efficiency of recovery for most BCC strains from the CHX and BZK solutions than full strength TSA or R2A. For BCC survival in antiseptic solutions, the cell number of BCC decreased rapidly within the first 20 min in both antiseptics, but after this, recovery remained constant in CHX and increased in BZK over the 14 day incubation period. The results indicate that BCC in water can remain viable with low susceptibility to antiseptics for 14 days, which suggests the necessity for improved detection methods and control measures to monitor BCC contamination in pharmaceutical products. JF - Journal of industrial microbiology & biotechnology AU - Kim, Jeong Myeong AU - Ahn, Youngbeom AU - LiPuma, John J AU - Hussong, David AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079-9502, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 905 EP - 913 VL - 42 IS - 6 KW - Anti-Infective Agents, Local KW - 0 KW - Benzalkonium Compounds KW - Disinfectants KW - chlorhexidine gluconate KW - MOR84MUD8E KW - Chlorhexidine KW - R4KO0DY52L KW - Index Medicus KW - Drug Contamination KW - Microbial Sensitivity Tests KW - Chlorhexidine -- analogs & derivatives KW - Benzalkonium Compounds -- pharmacology KW - Anti-Infective Agents, Local -- pharmacology KW - Chlorhexidine -- pharmacology KW - Microbial Viability -- drug effects KW - Burkholderia cepacia complex -- drug effects KW - Disinfectants -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680955997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+industrial+microbiology+%26+biotechnology&rft.atitle=Survival+and+susceptibility+of+Burkholderia+cepacia+complex+in+chlorhexidine+gluconate+and+benzalkonium+chloride.&rft.au=Kim%2C+Jeong+Myeong%3BAhn%2C+Youngbeom%3BLiPuma%2C+John+J%3BHussong%2C+David%3BCerniglia%2C+Carl+E&rft.aulast=Kim&rft.aufirst=Jeong&rft.date=2015-06-01&rft.volume=42&rft.issue=6&rft.spage=905&rft.isbn=&rft.btitle=&rft.title=Journal+of+industrial+microbiology+%26+biotechnology&rft.issn=1476-5535&rft_id=info:doi/10.1007%2Fs10295-015-1605-x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-21 N1 - Date created - 2015-05-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10295-015-1605-x ER - TY - JOUR T1 - Different cytotoxicity responses to antimicrobial nanosilver coatings when comparing extract-based and direct-contact assays AN - 1680451609; PQ0001489118 AB - This study was performed to understand how the choice of cytotoxicity assay format affects the observed biocompatibility of nanosilver (nAg). nAg coatings are physical coatings containing silver (Ag) that have feature sizes of 100nm or less, often in the form of nanoparticles or grains. They are used on medical devices to prevent infection, but in spite of this intended benefit, observations of potential cytotoxicity from nAg have been reported in numerous published studies. For medical device regulation, cytotoxicity testing is part of a biocompatibility evaluation, in which specific test methods are chosen based on the technological characteristics and intended use of a device. For this study, nAg-coated tissue culture polystyrene surfaces were prepared using magnetron sputter coating, resulting in nAg films of 0.2 to 311 mu gcm super(-2) Ag. These coatings exhibited nanometer-scale morphologies and demonstrated a>4log sub(10) reduction in Escherichia coli viability. It was observed that extracts of nAg caused no cytotoxicity to L929 mouse fibroblasts, but cells cultured directly on nAg coatings (direct-contact assay format) showed a dose-dependent reduction in viability by up to 100% (P<0.001). Results using inductively coupled plasma mass spectrometry to measure Ag release suggested that extracts of nAg are not toxic because the dissolved Ag in those samples becomes less cytotoxic over time, probably owing to the reaction with cell culture media and serum (six-fold cytotoxicity reductions observed over a 24-h period). These findings highlight the potential value of direct-contact cytotoxicity testing for nAg in predicting biological interactions with cells or tissue in vivo. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. Nanosilver (nAg) coatings are used as antimicrobial coatings on medical devices, but in spite of their intended benefit, there is concern over their potential toxicity. This study compares the response of cells to nAg in two formats of the cytotoxicity assay, an important component of biocompatibility evaluation. The results demonstrate cytotoxic responses to nAg coatings in the direct-contact but not the extract assay (100% reduction, P<0.001), suggesting that nAg coatings in direct contact with cells and tissues could cause a cytotoxic response. JF - Journal of Applied Toxicology AU - Sussman, Eric M AU - Casey, Brendan J AU - Dutta, Debargh AU - Dair, Benita J AD - Division of Biology, Chemistry and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA. PY - 2015 SP - 631 EP - 639 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 35 IS - 6 SN - 0260-437X, 0260-437X KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Biocompatibility KW - Cell culture KW - Tissue culture KW - Toxicity KW - Infection KW - Cytotoxicity testing KW - Mass spectroscopy KW - Fibroblasts KW - Antimicrobial agents KW - Cytotoxicity KW - Escherichia coli KW - polystyrene KW - Grain KW - nanoparticles KW - Silver KW - Media (culture) KW - Films KW - Coatings KW - J 02410:Animal Diseases KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680451609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Different+cytotoxicity+responses+to+antimicrobial+nanosilver+coatings+when+comparing+extract-based+and+direct-contact+assays&rft.au=Sussman%2C+Eric+M%3BCasey%2C+Brendan+J%3BDutta%2C+Debargh%3BDair%2C+Benita+J&rft.aulast=Sussman&rft.aufirst=Eric&rft.date=2015-06-01&rft.volume=35&rft.issue=6&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3104 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Biocompatibility; Cell culture; Toxicity; Tissue culture; Infection; Cytotoxicity testing; Mass spectroscopy; Antimicrobial agents; Fibroblasts; Cytotoxicity; Grain; polystyrene; Silver; nanoparticles; Media (culture); Coatings; Films; Escherichia coli DO - http://dx.doi.org/10.1002/jat.3104 ER - TY - JOUR T1 - Influence of yogurt fermentation and refrigerated storage on the stability of protein toxin contaminants. AN - 1680210223; 25772284 AB - Dairy products sold in a ready-to-eat form present the risk that adulterants persisting through manufacturing, storage, and distribution would reach consumers. Pathogenic microbes, including shigatoxigenic strains of Escherichia coli and the toxins they produce, are common food safety hazards associated with dairy products. Ricin and abrin are plant-derived ribosome-inactivating protein toxins related to the shiga-like toxins produced by E. coli. Limited information exists on the effects of manufacturing processes on the stabilities of these heat-resistant ribosome-inactivating proteins in the presence of foods. The goal of this study was to determine how typical yogurt manufacturing and storage processes influence ribosome-inactivating protein toxins. Ricin and abrin were added to skim or whole milk and batch pasteurized. Complete inactivation of both toxins was observed after 30 minutes at 85 °C. If the toxins were added after pasteurization, the levels of ricin and abrin in yogurt and their cytotoxic activities did not change significantly during fermentation or refrigerated storage for 4 weeks. The activities of ricin and abrin were inhibited by skim milk, nonfat yogurt, whole milk, and whole milk yogurt. The results showed minimal effects of the toxins on yogurt pH and %titratable acidity but inhibitory effects of yogurt on toxin activity. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Jackson, Lauren S AU - Triplett, Odbert A AU - Tolleson, William H AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, 6502 S. Archer Rd., Bedford Park, IL 60501, USA. ; Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR, USA. ; Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Rd, Jefferson, AR, USA. Electronic address: william.tolleson@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 101 EP - 107 VL - 80 KW - Bacterial Toxins KW - 0 KW - Abrin KW - 1393-62-0 KW - Ricin KW - 9009-86-3 KW - Index Medicus KW - Yogurt KW - Dairy KW - Manufacture KW - Stability KW - Food Microbiology KW - Fermentation KW - Abrin -- chemistry KW - Food Handling KW - Pasteurization KW - Ricin -- chemistry KW - Refrigeration KW - Yogurt -- microbiology KW - Yogurt -- analysis KW - Food Storage KW - Food Contamination KW - Bacterial Toxins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680210223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Influence+of+yogurt+fermentation+and+refrigerated+storage+on+the+stability+of+protein+toxin+contaminants.&rft.au=Jackson%2C+Lauren+S%3BTriplett%2C+Odbert+A%3BTolleson%2C+William+H&rft.aulast=Jackson&rft.aufirst=Lauren&rft.date=2015-06-01&rft.volume=80&rft.issue=&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-25 N1 - Date created - 2015-05-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.03.003 ER - TY - JOUR T1 - Investigation of melamine and cyanuric acid deposition in pig tissues using LC-MS/MS methods. AN - 1680209200; 25818466 AB - Four LC-MS/MS methods were developed to quantify melamine (MEL) and cyanuric acid (CYA) in various pig tissues at or above the level of concern (2.5 mg/kg). Pigs treated with 200 mg/kg bw/day CYA daily for 7 days did not accumulate significant residue concentrations in muscle, liver or kidney. Pigs treated with 200 mg/kg bw MEL daily for 7 or 28 days had MEL residues in muscles (3-13 ppm), liver (2.8-14.1 ppm) and kidney (9.4-27.2 ppm). Treatment with MEL and CYA at 100 mg/kg bw of each triazine daily for 7 days resulted in MEL (26-59 ppm in muscle, 30-49 ppm in liver and 367-6300 ppm in kidney) and CYA (1.8-5.8 ppm in muscle, 2.6-6.5 ppm in liver and 303-7100 ppm in kidney). Treatment with MEL and CYA at 1, 3 or 10 mg/kg bw/day for 7 days did not result in residues greater than the level of concern in all tissues tested. Pigs dosed with 33 mg/kg bw/day of MEL + CYA for 7 days contained residues above the level of concern only in kidney. Deposition of MEL and CYA depends on the tissue type (muscles, liver and kidney), dosage and whether the triazines are given alone or in combination. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Tkachenko, Andriy AU - Clark, James AU - Knutson, Natalie AU - Wallace, Betzy AU - Bomba, Malgorzata AU - Yacopucci, Michele AU - Rhodes, Blaine AU - Nemser, Sarah M AU - Guag, Jake AU - Reimschuessel, Renate AD - United States Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd., Laurel, MD 20708, USA. ; State Laboratory, Arizona Department of Health Services, 250 N. 17th Avenue, Phoenix, AZ 85007, USA. ; New Hampshire State Public Health Laboratory, 29 Hazen Drive, Concord, NH 03301, USA. ; Washington State Public Health Laboratory, 1610 N.E. 150th St., Shoreline, WA 98155, USA. ; United States Food and Drug Administration, Center for Veterinary Medicine, Office of Research, 8401 Muirkirk Rd., Laurel, MD 20708, USA. Electronic address: renate.reimschuessel@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 310 EP - 318 VL - 80 KW - Triazines KW - 0 KW - cyanuric acid KW - H497R4QKTZ KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Residues KW - Melamine KW - Pig KW - Mass spectrometry KW - Cyanuric acid KW - Animals KW - Reproducibility of Results KW - Dose-Response Relationship, Drug KW - Chromatography, Liquid KW - Tandem Mass Spectrometry KW - Triazines -- metabolism KW - Kidney -- chemistry KW - Swine -- metabolism KW - Muscle, Skeletal -- chemistry KW - Liver -- chemistry KW - Triazines -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680209200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Investigation+of+melamine+and+cyanuric+acid+deposition+in+pig+tissues+using+LC-MS%2FMS+methods.&rft.au=Tkachenko%2C+Andriy%3BClark%2C+James%3BKnutson%2C+Natalie%3BWallace%2C+Betzy%3BBomba%2C+Malgorzata%3BYacopucci%2C+Michele%3BRhodes%2C+Blaine%3BNemser%2C+Sarah+M%3BGuag%2C+Jake%3BReimschuessel%2C+Renate&rft.aulast=Tkachenko&rft.aufirst=Andriy&rft.date=2015-06-01&rft.volume=80&rft.issue=&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.03.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-25 N1 - Date created - 2015-05-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.03.007 ER - TY - JOUR T1 - A retrospective analysis of allergic reaction severities and minimal eliciting doses for peanut, milk, egg, and soy oral food challenges. AN - 1680209146; 25748389 AB - Food allergy is a public health concern, affecting up to 6% of children and 2% of adults. The severity of allergic reactions can range from mild to potentially life-threatening. In addition, the minimum amount of protein needed to provoke an allergic reaction in an individual patient (the minimal eliciting dose (MED)) ranges from a few micrograms to several grams. To determine whether a retrospective analysis of published data from oral food challenges could be used to assess the potential relationship between MEDs and reaction severities at the MEDs, a three class (mild, moderate, severe) reaction grading system was developed by integrating previously published reaction grading systems. MEDs and symptoms were collected from food challenge studies and each reaction was graded using the integrated grading system. Peanut allergic patients who experienced severe reactions had significantly higher MEDs and threshold distribution doses than those who experienced mild and moderate reactions. No significant differences in threshold distributions according to the severity grading were found for milk, egg and soy. The relationship between threshold dose distribution and reaction severity based on these grading criteria differed between peanut and other allergens, and severe reactions were found to occur in some patients at low MEDs for all of these food allergens. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Zhu, Jianmei AU - Pouillot, Régis AU - Kwegyir-Afful, Ernest K AU - Luccioli, Stefano AU - Gendel, Steven M AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. ; Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA. Electronic address: steven.gendel@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 92 EP - 100 VL - 80 KW - Allergens KW - 0 KW - Index Medicus KW - Food allergen KW - Oral food challenges KW - Reaction severity KW - Eliciting dose KW - Animals KW - Humans KW - Dose-Response Relationship, Immunologic KW - Retrospective Studies KW - Milk Hypersensitivity KW - Peanut Hypersensitivity KW - Soy Foods KW - Allergens -- administration & dosage KW - Egg Hypersensitivity KW - Food Hypersensitivity -- pathology KW - Food Hypersensitivity -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680209146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=A+retrospective+analysis+of+allergic+reaction+severities+and+minimal+eliciting+doses+for+peanut%2C+milk%2C+egg%2C+and+soy+oral+food+challenges.&rft.au=Zhu%2C+Jianmei%3BPouillot%2C+R%C3%A9gis%3BKwegyir-Afful%2C+Ernest+K%3BLuccioli%2C+Stefano%3BGendel%2C+Steven+M&rft.aulast=Zhu&rft.aufirst=Jianmei&rft.date=2015-06-01&rft.volume=80&rft.issue=&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.02.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-25 N1 - Date created - 2015-05-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.02.023 ER - TY - JOUR T1 - Genomics in the land of regulatory science. AN - 1675876549; 25796433 AB - Genomics science has played a major role in the generation of new knowledge in the basic research arena, and currently question arises as to its potential to support regulatory processes. However, the integration of genomics in the regulatory decision-making process requires rigorous assessment and would benefit from consensus amongst international partners and research communities. To that end, the Global Coalition for Regulatory Science Research (GCRSR) hosted the fourth Global Summit on Regulatory Science (GSRS2014) to discuss the role of genomics in regulatory decision making, with a specific emphasis on applications in food safety and medical product development. Challenges and issues were discussed in the context of developing an international consensus for objective criteria in the analysis, interpretation and reporting of genomics data with an emphasis on transparency, traceability and "fitness for purpose" for the intended application. It was recognized that there is a need for a global path in the establishment of a regulatory bioinformatics framework for the development of transparent, reliable, reproducible and auditable processes in the management of food and medical product safety risks. It was also recognized that training is an important mechanism in achieving internationally consistent outcomes. GSRS2014 provided an effective venue for regulators andresearchers to meet, discuss common issues, and develop collaborations to address the challenges posed by the application of genomics to regulatory science, with the ultimate goal of wisely integrating novel technical innovations into regulatory decision-making. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Tong, Weida AU - Ostroff, Stephen AU - Blais, Burton AU - Silva, Primal AU - Dubuc, Martine AU - Healy, Marion AU - Slikker, William AD - National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. Electronic address: Weida.tong@fda.hhs.gov. ; Office of the Chief Scientist, US Food and Drug Administration, Silver Spring, MD, USA. ; Canadian Food Inspection Agency, Ottawa, Ontario, Canada. ; Foods Standards Australia New Zealand, Canberra, ACT, Australia. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. Electronic address: William.slikker@fda.hhs.gov. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 102 EP - 106 VL - 72 IS - 1 KW - Index Medicus KW - Regulatory science KW - Next generation sequencing KW - Genomics KW - Humans KW - Computational Biology -- methods KW - Food Safety -- methods KW - Decision Making KW - Genomics -- methods KW - Science -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675876549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Genomics+in+the+land+of+regulatory+science.&rft.au=Tong%2C+Weida%3BOstroff%2C+Stephen%3BBlais%2C+Burton%3BSilva%2C+Primal%3BDubuc%2C+Martine%3BHealy%2C+Marion%3BSlikker%2C+William&rft.aulast=Tong&rft.aufirst=Weida&rft.date=2015-06-01&rft.volume=72&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2015.03.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-13 N1 - Date created - 2015-04-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2015.03.008 ER - TY - JOUR T1 - Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness. AN - 1675169335; 25753028 AB - Gulf War Illness (GWI) is a multi-symptom disorder with features characteristic of persistent sickness behavior. Among conditions encountered in the Gulf War (GW) theater were physiological stressors (e.g., heat/cold/physical activity/sleep deprivation), prophylactic treatment with the reversible AChE inhibitor, pyridostigmine bromide (PB), the insect repellent, N,N-diethyl-meta-toluamide (DEET), and potentially the nerve agent, sarin. Prior exposure to the anti-inflammatory glucocorticoid, corticosterone (CORT), at levels associated with high physiological stress, can paradoxically prime the CNS to produce a robust proinflammatory response to neurotoxicants and systemic inflammation; such neuroinflammatory effects can be associated with sickness behavior. Here, we examined whether CORT primed the CNS to mount neuroinflammatory responses to GW exposures as a potential model of GWI. Male C57BL/6 mice were treated with chronic (14 days) PB/ DEET, subchronic (7-14 days) CORT, and acute exposure (day 15) to diisopropyl fluorophosphate (DFP), a sarin surrogate and irreversible AChE inhibitor. DFP alone caused marked brain-wide neuroinflammation assessed by qPCR of tumor necrosis factor-α, IL6, chemokine (C-C motif) ligand 2, IL-1β, leukemia inhibitory factor, and oncostatin M. Pre-treatment with high physiological levels of CORT greatly augmented (up to 300-fold) the neuroinflammatory responses to DFP. Anti-inflammatory pre-treatment with minocycline suppressed many proinflammatory responses to CORT+DFP. Our findings are suggestive of a possible critical, yet unrecognized interaction between the stressor/environment of the GW theater and agent exposure(s) unique to this war. Such exposures may in fact prime the CNS to amplify future neuroinflammatory responses to pathogens, injury, or toxicity. Such occurrences could potentially result in the prolonged episodes of sickness behavior observed in GWI. Gulf War (GW) veterans were exposed to stressors, prophylactic medicines and, potentially, nerve agents in theater. Subsequent development of GW Illness, a persistent multi-symptom disorder with features characteristic of sickness behavior, may be caused by priming of the CNS resulting in exaggerated neuroinflammatory responses to pathogens/insults. Nerve agent, diisopropyl fluorophosphate (DFP), produced a neuroinflammatory response that was exacerbated by pre-treatment with levels of corticosterone simulating heightened stressor conditions. While prophylactic treatments reduced DFP-induced neuroinflammation, this effect was negated when those treatments were combined with corticosterone. © 2015 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of The International Society for Neurochemistry. JF - Journal of neurochemistry AU - O'Callaghan, James P AU - Kelly, Kimberly A AU - Locker, Alicia R AU - Miller, Diane B AU - Lasley, Steve M AD - Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 708 EP - 721 VL - 133 IS - 5 KW - Anti-Inflammatory Agents KW - 0 KW - Chemical Warfare Agents KW - Cholinesterase Inhibitors KW - Insect Repellents KW - Isoflurophate KW - 12UHW9R67N KW - DEET KW - 134-62-3 KW - Minocycline KW - FYY3R43WGO KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - microglia KW - GWI KW - minocycline KW - CORT KW - neuroinflammation KW - DFP KW - Animals KW - Dose-Response Relationship, Drug KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Insect Repellents -- toxicity KW - Minocycline -- therapeutic use KW - DEET -- toxicity KW - Male KW - Persian Gulf Syndrome -- pathology KW - Cholinesterase Inhibitors -- toxicity KW - Anti-Inflammatory Agents -- therapeutic use KW - Isoflurophate -- antagonists & inhibitors KW - Corticosterone -- antagonists & inhibitors KW - Encephalitis -- chemically induced KW - Corticosterone -- pharmacology KW - Chemical Warfare Agents -- toxicity KW - Isoflurophate -- toxicity KW - Anti-Inflammatory Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675169335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Corticosterone+primes+the+neuroinflammatory+response+to+DFP+in+mice%3A+potential+animal+model+of+Gulf+War+Illness.&rft.au=O%27Callaghan%2C+James+P%3BKelly%2C+Kimberly+A%3BLocker%2C+Alicia+R%3BMiller%2C+Diane+B%3BLasley%2C+Steve+M&rft.aulast=O%27Callaghan&rft.aufirst=James&rft.date=2015-06-01&rft.volume=133&rft.issue=5&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=1471-4159&rft_id=info:doi/10.1111%2Fjnc.13088 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-24 N1 - Date created - 2015-04-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/jnc.13088 ER - TY - JOUR T1 - Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability. AN - 1671213878; 25746383 AB - Impact on health by nanomaterials has become a public concern with the great advances of nanomaterials for various applications. Surface coating agents are an integral part of nanoparticles, but not enough attention has been paid during toxicity tests of nanoparticles. As a result, there are inconsistent toxicity results for certain nanomaterials. In this study, we explored the cytotoxicity of eleven commonly used surface coating agents in two cell lines, human epidermal keratinocyte (HaCaT) and lung fibroblast (CRL-1490) cells, at surface coating agent concentrations of 3, 10, 30, and 100 μM. Two exposure time points, 2 h and 24 h, were employed for the study. Six of the eleven surface coating agents are cytotoxic, especially those surfactants with long aliphatic chains, both cationic (cetyltrimethylammonium bromide, oleylamine, tetraoctylammonium bromide, and hexadecylamine) and anionic (sodium dodecylsulfate). In addition, exposure time and the use of different cell lines also affect the cytotoxicity results. Therefore, factors such as cell lines used and exposure times must be considered when conducting toxicity tests or comparing cytotoxicity results. Copyright © 2015 Elsevier Ltd. All rights reserved. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Zhang, Ying AU - Newton, Brandon AU - Lewis, Eybriunna AU - Fu, Peter P AU - Kafoury, Ramzi AU - Ray, Paresh C AU - Yu, Hongtao AD - Departments of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39127, USA. ; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA. ; Departments of Biology, Jackson State University, Jackson, MS 39127, USA. ; Departments of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39127, USA. Electronic address: yu@jsums.edu. Y1 - 2015/06// PY - 2015 DA - June 2015 SP - 762 EP - 768 VL - 29 IS - 4 KW - Amines KW - 0 KW - Organic Chemicals KW - Index Medicus KW - Surface coating agents KW - Cytotoxicity KW - Nanoparticle KW - SDS KW - Aliphatic amines KW - Cell Survival -- drug effects KW - Organic Chemicals -- toxicity KW - Humans KW - Amines -- toxicity KW - Toxicity Tests KW - Amines -- chemistry KW - Cell Line, Tumor KW - Nanostructures -- chemistry KW - Nanoparticles -- toxicity KW - Nanostructures -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671213878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Cytotoxicity+of+organic+surface+coating+agents+used+for+nanoparticles+synthesis+and+stability.&rft.au=Zhang%2C+Ying%3BNewton%2C+Brandon%3BLewis%2C+Eybriunna%3BFu%2C+Peter+P%3BKafoury%2C+Ramzi%3BRay%2C+Paresh+C%3BYu%2C+Hongtao&rft.aulast=Zhang&rft.aufirst=Ying&rft.date=2015-06-01&rft.volume=29&rft.issue=4&rft.spage=762&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2015.01.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-21 N1 - Date created - 2015-04-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Sci Technol. 2013 Sep 17;47(18):10293-301 [23952964] Langmuir. 2013 Apr 16;29(15):4647-51 [23544954] Toxicol Ind Health. 2014 Jul;30(6):489-98 [23012341] Am J Respir Crit Care Med. 1999 Dec;160(6):1934-42 [10588609] Nat Biotechnol. 2003 Oct;21(10):1166-70 [14520401] Arch Toxicol. 1974;32(4):245-70 [4614759] Toxicol Appl Pharmacol. 1998 Jun;150(2):338-49 [9653065] Biomaterials. 2005 Oct;26(29):5818-26 [15949547] Toxicol Lett. 2005 Aug 14;158(2):122-32 [16039401] Small. 2005 Mar;1(3):325-7 [17193451] Small. 2006 Jun;2(6):766-73 [17193121] Small. 2009 Mar;5(6):701-8 [19226599] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Jan;27(1):1-35 [19204862] Environ Toxicol. 2007 Apr;22(2):159-68 [17366569] Environ Sci Technol. 2010 Jul 1;44(13):5210-5 [20509652] Sci Total Environ. 2010 Sep 15;408(20):4475-81 [20673962] Chem Rev. 2010 Sep 8;110(9):5332-65 [20469927] Environ Sci Technol. 2011 Jun 15;45(12):5260-6 [21598969] Environ Sci Technol. 2012 Jan 17;46(2):1119-27 [22148238] Toxicol In Vitro. 2013 Feb;27(1):330-8 [22940466] J Food Drug Anal. 2014 Mar;22(1):116-27 [24673909] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2015.01.017 ER - TY - CPAPER T1 - Traceability and Food Safety Systems T2 - 115th General Meeting of the American Society for Microbiology (ASM 2015) AN - 1658698535; 6336180 JF - 115th General Meeting of the American Society for Microbiology (ASM 2015) AU - Elliott, Elisa Y1 - 2015/05/30/ PY - 2015 DA - 2015 May 30 KW - Food KW - Food contamination KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658698535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2015%29&rft.atitle=Traceability+and+Food+Safety+Systems&rft.au=Elliott%2C+Elisa&rft.aulast=Elliott&rft.aufirst=Elisa&rft.date=2015-05-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={224BAD71-94EA-4FA5-8DF3-F4087BDC3625} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-28 N1 - Last updated - 2015-02-27 ER - TY - JOUR T1 - Incubation of Methamphetamine Craving Is Associated with Selective Increases in Expression of Bdnf and Trkb, Glutamate Receptors, and Epigenetic Enzymes in Cue-Activated Fos-Expressing Dorsal Striatal Neurons AN - 1735914723; PQ0002270521 AB - Cue-induced methamphetamine seeking progressively increases after withdrawal (incubation of methamphetamine craving), but the underlying mechanisms are largely unknown. We determined whether this incubation is associated with alterations in candidate genes in dorsal striatum (DS), a brain area implicated in cue- and context-induced drug relapse. We first measured mRNA expression of 24 candidate genes in whole DS extracts after short (2 d) or prolonged (1 month) withdrawal in rats following extended-access methamphetamine or saline (control condition) self-administration (9 h/d, 10 d). We found minimal changes. Next, using fluorescence-activated cell sorting, we compared gene expression in Fos-positive dorsal striatal neurons, which were activated during "incubated" cue-induced drug-seeking tests after prolonged withdrawal, with nonactivated Fos-negative neurons. We found significant increases in mRNA expression of immediate early genes (Arc, Egr1), Bdnf and its receptor (rkb), glutamate receptor subunits (Gria1, Gria3, Grm1), and epigenetic enzymes (Hdac3, Hdac4, Hdac5, GLP, Dnmt3a, Kdm1a) in the Fos-positive neurons only. Using RNAscope to determine striatal subregion and cell-type specificity of the activated neurons, we measured colabeling of Fos with Drd1 and Drd2 in three DS subregions. Fos expression was neither subregion nor cell-type specific (52.5 and 39.2% of Fos expression colabeled with Drd1 and Drd2, respectively). Finally, we found that DS injections of SCH23390 (C sub(17)H sub(18)CINO), a D sub(1)-family receptor antagonist known to block cue-induced Fos induction, decreased incubated cue-induced methamphetamine seeking after prolonged withdrawal. Results demonstrate a critical role of DS in incubation of methamphetamine craving and that this incubation is associated with selective gene-expression alterations in cue-activated D sub(1)- and D sub(2)-expressing DS neurons. JF - Journal of Neuroscience AU - Li, Xuan AU - Rubio, F Javier AU - Zeric, Tamara AU - Bossert, Jennifer M AU - Kambhampati, Sarita AU - Cates, Hannah M AU - Kennedy, Pamela J AU - Liu, Qing-Rong AU - Cimbro, Raffaello AU - Hope, Bruce T AU - Nestler, Eric J AU - Shaham, Yavin AD - Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, U.S. Department of Health and Human Services, Baltimore, Maryland 21224 Y1 - 2015/05/27/ PY - 2015 DA - 2015 May 27 SP - 8232 EP - 8244 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Washington DC 20036 United States VL - 35 IS - 21 SN - 0270-6474, 0270-6474 KW - Toxicology Abstracts; Animal Behavior Abstracts; CSA Neurosciences Abstracts KW - dorsal striatum KW - epigenetics KW - FACS KW - glutamate KW - methamphetamine KW - relapse KW - Dopamine D2 receptors KW - Brain-derived neurotrophic factor KW - Dopamine D1 receptors KW - Enzymes KW - Drug development KW - Drug abuse KW - Glutamic acid receptors KW - Fos protein KW - Flow cytometry KW - Gene expression KW - TrkB receptors KW - Methamphetamine KW - Nervous system KW - Neurons KW - Neostriatum KW - Self-administration KW - Immediate-early proteins KW - Drug addiction KW - EGR-1 protein KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience KW - Y 25050:Genetics and Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735914723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Incubation+of+Methamphetamine+Craving+Is+Associated+with+Selective+Increases+in+Expression+of+Bdnf+and+Trkb%2C+Glutamate+Receptors%2C+and+Epigenetic+Enzymes+in+Cue-Activated+Fos-Expressing+Dorsal+Striatal+Neurons&rft.au=Li%2C+Xuan%3BRubio%2C+F+Javier%3BZeric%2C+Tamara%3BBossert%2C+Jennifer+M%3BKambhampati%2C+Sarita%3BCates%2C+Hannah+M%3BKennedy%2C+Pamela+J%3BLiu%2C+Qing-Rong%3BCimbro%2C+Raffaello%3BHope%2C+Bruce+T%3BNestler%2C+Eric+J%3BShaham%2C+Yavin&rft.aulast=Li&rft.aufirst=Xuan&rft.date=2015-05-27&rft.volume=35&rft.issue=21&rft.spage=8232&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/10.1523%2FJNEUROSCI.102215.2015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Brain-derived neurotrophic factor; Dopamine D2 receptors; Dopamine D1 receptors; Enzymes; Drug development; Drug abuse; Glutamic acid receptors; Fos protein; Gene expression; Flow cytometry; TrkB receptors; Nervous system; Methamphetamine; epigenetics; Neurons; Neostriatum; Self-administration; Immediate-early proteins; Drug addiction; EGR-1 protein DO - http://dx.doi.org/10.1523/JNEUROSCI.102215.2015 ER - TY - GEN T1 - Family and Provider/Teacher Relationship Quality: Director Measure AN - 1773221727; ED558536 AB - The director measure is intended for use with program directors in center-based, family child care, and Head Start/Early Head Start settings for children from birth through five years old. This measure asks respondents general questions about the early childhood education environment, the children enrolled in the program, and how the program supports family and provider/teacher relationships. It includes 57 items and takes about 10 minutes to complete, on average. The Excel scoring sheet for the director measure (revised April 2015) can be used to automatically calculate scores for the environment and policy checklist in the director measure. It is available in English only. Y1 - 2015/05/19/ PY - 2015 DA - 2015 May 19 SP - 6 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Administrators KW - Early Childhood Education KW - Preschool Education KW - Preschool Teachers KW - Measures (Individuals) KW - Educational Environment KW - Family School Relationship KW - Enrollment KW - Preschool Children KW - Interpersonal Relationship UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221727?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Spontaneous pharyngeal Chlamydia trachomatis RNA clearance. A cross-sectional study followed by a cohort study of untreated STI clinic patients in Amsterdam, The Netherlands AN - 1819139753; PQ0003430239 AB - ObjectivesPharyngeal Chlamydia trachomatis (chlamydia) might contribute to ongoing chlamydia transmission, yet data on spontaneous clearance duration are rare. We examined the prevalence, spontaneous clearance, chlamydial DNA concentration and genotypes of pharyngeal chlamydia among clinic patients with sexually transmitted infection (STI).MethodsFemale patients at high risk for an STI who reported active oral sex and male patients who have sex with men (MSM) were screened for pharyngeal chlamydia RNA using a nucleic acid amplification test. A repeat swab was obtained to evaluate spontaneous clearance in untreated patients with pharyngeal chlamydia. Quantitative chlamydia DNA load was determined by calculating the chlamydia/human cell ratio.ResultsPharyngeal chlamydia was detected in 148/13111 (1.1%) MSM and in 160/6915 (2.3%) women. 53% of MSM and 32% of women with pharyngeal chlamydia did not have a concurrent anogenital chlamydia infection. In 16/43 (37%) MSM and in 20/55 (36%) women, the repeat pharyngeal swab was negative (median follow-up 10days, range 4-58days). Patients with an initial chlamydial DNA concentration above the median were less likely to clear. Of 23 MSM with pharyngeal chlamydia who had sex with a lymphogranuloma venereum (LGV)-positive partner recently or in the past, two were LGV biovar positive (8.7%).ConclusionsThe pharynx is a reservoir for chlamydia and LGV, and may play a role in ongoing transmission. Although delay in ribosomal RNA decline after resolution of the infection might have led to an underestimation of spontaneous clearance, in high-risk STI clinic patients, testing the pharynx for chlamydia should be considered. JF - Sexually Transmitted Infections AU - van Rooijen, Martijn S AU - van der Loeff, Maarten F Schim AU - Morre, Servaas A AU - van Dam, Alje P AU - Speksnijder, Arjen G C L AU - de Vries, Henry J C AD - Public Health Laboratory, Public Health Service of Amsterdam (GGD Amsterdam), , Amsterdam, The Netherlands Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 SP - 157 EP - 164 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 91 IS - 3 SN - 1368-4973, 1368-4973 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - CHLAMYDIA TRACHOMATIS KW - ORAL CAVITY KW - ORAL SEX KW - SCREENING KW - TESTING KW - Pharynx KW - Data processing KW - Anogenital KW - Lymphogranuloma venereum KW - Chlamydia trachomatis KW - Genotypes KW - Infection KW - rRNA KW - nucleic acids KW - Risk factors KW - Risk groups KW - Sex KW - J 02400:Human Diseases KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1819139753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=Spontaneous+pharyngeal+Chlamydia+trachomatis+RNA+clearance.+A+cross-sectional+study+followed+by+a+cohort+study+of+untreated+STI+clinic+patients+in+Amsterdam%2C+The+Netherlands&rft.au=van+Rooijen%2C+Martijn+S%3Bvan+der+Loeff%2C+Maarten+F+Schim%3BMorre%2C+Servaas+A%3Bvan+Dam%2C+Alje+P%3BSpeksnijder%2C+Arjen+G+C+L%3Bde+Vries%2C+Henry+J+C&rft.aulast=van+Rooijen&rft.aufirst=Martijn&rft.date=2015-05-18&rft.volume=91&rft.issue=3&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/10.1136%2Fsextrans-2014-051633 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - rRNA; nucleic acids; Data processing; Pharynx; Anogenital; Risk factors; Lymphogranuloma venereum; Risk groups; Genotypes; Infection; Sex; Chlamydia trachomatis DO - http://dx.doi.org/10.1136/sextrans-2014-051633 ER - TY - JOUR T1 - Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. AN - 1681916566; 25811541 AB - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious cutaneous adverse reactions. We mined the approved labels in Drugs@FDA, identified the SJS/TEN list of 259 small molecular drugs and biologics, and conducted systems pharmacological network analyses. Pharmacological network analysis revealed that drugs with treatment-related SJS and/or TEN are pharmacologically diverse and that the largest subnetwork is associated with antiepileptic drugs and their pharmacological targets. Our pharmacological network analysis identified CTNNB1 [catenin (cadherin-associated protein), beta 1, 88 kDa] as a significant intermediator. This protein is involved in maintaining the functional integrity of the epithelium through regulating cell growth and adhesion between cells in various organs, including the skin. Leveraging a publicly accessible genome-wide transcriptional expression database, we found that human leukocyte antigen-related (HLA) genes were significantly perturbed by various SJS/TEN-inducing drugs. Notably, carbamazepine (CBZ) perturbed several HLA genes, among which HLA-DQB1*0201 was reportedly shown to be associated with CBZ-induced SJS/TEN in caucasians. In short, systems analysis by leveraging a publicly accessible knowledge base and databases could produce meaningful results for further mechanistic investigation. Our study sheds light on the utility of systems pharmacology analysis for gaining insight into clinical drug toxicity. JF - Chemical research in toxicology AU - Hur, Junguk AU - Zhao, ChunSheng AU - Bai, Jane P F AD - ‡Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, United States. ; §Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, United States. Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 SP - 927 EP - 934 VL - 28 IS - 5 KW - Anticonvulsants KW - 0 KW - CTNNB1 protein, human KW - HLA-DQ beta-Chains KW - HLA-DQB1 antigen KW - Small Molecule Libraries KW - beta Catenin KW - Carbamazepine KW - 33CM23913M KW - Index Medicus KW - Carbamazepine -- adverse effects KW - Databases, Pharmaceutical KW - Risk Factors KW - Humans KW - beta Catenin -- metabolism KW - Gene Expression Regulation -- drug effects KW - HLA-DQ beta-Chains -- genetics KW - Small Molecule Libraries -- adverse effects KW - Anticonvulsants -- adverse effects KW - Stevens-Johnson Syndrome -- etiology KW - Stevens-Johnson Syndrome -- genetics KW - Stevens-Johnson Syndrome -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1681916566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Systems+pharmacological+analysis+of+drugs+inducing+stevens-johnson+syndrome+and+toxic+epidermal+necrolysis.&rft.au=Hur%2C+Junguk%3BZhao%2C+ChunSheng%3BBai%2C+Jane+P+F&rft.aulast=Hur&rft.aufirst=Junguk&rft.date=2015-05-18&rft.volume=28&rft.issue=5&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx5005248 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-10 N1 - Date created - 2015-05-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/tx5005248 ER - TY - CPAPER T1 - Use of Smartphone Sound Measurement Apps for Occupational Noise Assessments T2 - 169th Meeting of the Acoustical Society of America AN - 1669823919; 6341645 JF - 169th Meeting of the Acoustical Society of America AU - Kardous, Chucri AU - Celestina, Metod Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Sound measurement KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Use+of+Smartphone+Sound+Measurement+Apps+for+Occupational+Noise+Assessments&rft.au=Kardous%2C+Chucri%3BCelestina%2C+Metod&rft.aulast=Kardous&rft.aufirst=Chucri&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Comparison of Headphones for Audiometric Screening and Hearing Protector Fit-Testing T2 - 169th Meeting of the Acoustical Society of America AN - 1669823090; 6341647 JF - 169th Meeting of the Acoustical Society of America AU - Byrne, David AU - Schmitt, Laura AU - Murph, William Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Screening KW - Hearing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Comparison+of+Headphones+for+Audiometric+Screening+and+Hearing+Protector+Fit-Testing&rft.au=Byrne%2C+David%3BSchmitt%2C+Laura%3BMurph%2C+William&rft.aulast=Byrne&rft.aufirst=David&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Relationships among Ultrasonic and Mechanical Properties of Cancellous Bone T2 - 169th Meeting of the Acoustical Society of America AN - 1669822902; 6341627 JF - 169th Meeting of the Acoustical Society of America AU - Wear, Keith AU - Sadoughi, Saghi AU - Nagaraja, Srinidhi AU - Dreher, Maureen AU - Keaveny, Tony Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Bone (cancellous) KW - Ultrasound KW - Mechanical properties UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Relationships+among+Ultrasonic+and+Mechanical+Properties+of+Cancellous+Bone&rft.au=Wear%2C+Keith%3BSadoughi%2C+Saghi%3BNagaraja%2C+Srinidhi%3BDreher%2C+Maureen%3BKeaveny%2C+Tony&rft.aulast=Wear&rft.aufirst=Keith&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - A Simple Animal Model for Cerebral Vasculature Rupture Due to Exposure to Intense Pressure Waves T2 - 169th Meeting of the Acoustical Society of America AN - 1669822539; 6341942 JF - 169th Meeting of the Acoustical Society of America AU - Nabili, Marjan AU - Acharya, Priyanka AU - Kim, Yeon AU - Myers, Matthew Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Wave forces KW - Animal models KW - Rupture KW - Waves KW - Pressure KW - Elastic waves UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=A+Simple+Animal+Model+for+Cerebral+Vasculature+Rupture+Due+to+Exposure+to+Intense+Pressure+Waves&rft.au=Nabili%2C+Marjan%3BAcharya%2C+Priyanka%3BKim%2C+Yeon%3BMyers%2C+Matthew&rft.aulast=Nabili&rft.aufirst=Marjan&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Field Evaluations of a Noise Control for Roof Bolting Machines T2 - 169th Meeting of the Acoustical Society of America AN - 1669822531; 6341891 JF - 169th Meeting of the Acoustical Society of America AU - Azman, Amanda Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Noise levels KW - Bolting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Field+Evaluations+of+a+Noise+Control+for+Roof+Bolting+Machines&rft.au=Azman%2C+Amanda&rft.aulast=Azman&rft.aufirst=Amanda&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Acoustic requirements for audiometric testing and hearing protector fit-testing with mobile platforms T2 - 169th Meeting of the Acoustical Society of America AN - 1669822070; 6341646 JF - 169th Meeting of the Acoustical Society of America AU - Murphy, William Y1 - 2015/05/18/ PY - 2015 DA - 2015 May 18 KW - Acoustics KW - Mobile platforms KW - Hearing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=169th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Acoustic+requirements+for+audiometric+testing+and+hearing+protector+fit-testing+with+mobile+platforms&rft.au=Murphy%2C+William&rft.aulast=Murphy&rft.aufirst=William&rft.date=2015-05-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=169th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - https://asa2015spring.abstractcentral.com/planner.jsp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Integrated microRNA, mRNA, and protein expression profiling reveals microRNA regulatory networks in rat kidney treated with a carcinogenic dose of aristolochic acid. AN - 1686996850; 25952319 AB - Aristolochic Acid (AA), a natural component of Aristolochia plants that is found in a variety of herbal remedies and health supplements, is classified as a Group 1 carcinogen by the International Agency for Research on Cancer. Given that microRNAs (miRNAs) are involved in cancer initiation and progression and their role remains unknown in AA-induced carcinogenesis, we examined genome-wide AA-induced dysregulation of miRNAs as well as the regulation of miRNAs on their target gene expression in rat kidney. We treated rats with 10 mg/kg AA and vehicle control for 12 weeks and eight kidney samples (4 for the treatment and 4 for the control) were used for examining miRNA and mRNA expression by deep sequencing, and protein expression by proteomics. AA treatment resulted in significant differential expression of miRNAs, mRNAs and proteins as measured by both principal component analysis (PCA) and hierarchical clustering analysis (HCA). Specially, 63 miRNAs (adjusted p value 1.5), 6,794 mRNAs (adjusted p value 2.0), and 800 proteins (fold change > 2.0) were significantly altered by AA treatment. The expression of 6 selected miRNAs was validated by quantitative real-time PCR analysis. Ingenuity Pathways Analysis (IPA) showed that cancer is the top network and disease associated with those dysregulated miRNAs. To further investigate the influence of miRNAs on kidney mRNA and protein expression, we combined proteomic and transcriptomic data in conjunction with miRNA target selection as confirmed and reported in miRTarBase. In addition to translational repression and transcriptional destabilization, we also found that miRNAs and their target genes were expressed in the same direction at levels of transcription (169) or translation (227). Furthermore, we identified that up-regulation of 13 oncogenic miRNAs was associated with translational activation of 45 out of 54 cancer-related targets. Our findings suggest that dysregulated miRNA expression plays an important role in AA-induced carcinogenesis in rat kidney, and that the integrated approach of multiple profiling provides a new insight into a post-transcriptional regulation of miRNAs on their target repression and activation in a genome-wide scale. JF - BMC genomics AU - Li, Zhiguang AU - Qin, Taichun AU - Wang, Kejian AU - Hackenberg, Michael AU - Yan, Jian AU - Gao, Yuan AU - Yu, Li-Rong AU - Shi, Leming AU - Su, Zhenqiang AU - Chen, Tao AD - Institute of Cancer Stem Cell, Second Affiliated Hospital, Cancer Center, Dalian Medical University, Dalian, 116044, China. zhiguangli@dlmedu.edu.cn. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. qincharles1@gmail.com. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. kejian.wang.bio@gmail.com. ; Genetics Department, Facultad de Ciencias, Universidad de Granada, Granada, 18071, Spain. mlhack@gmail.com. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. jian.yan@fda.hhs.gov. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. yuan.gao@fda.hhs.gov. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. LiRong.Yu@fda.hhs.gov. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. leming.shi@gmail.com. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. Zhenqiang.Su@fda.hhs.gov. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA. tao.chen@fda.hhs.gov. Y1 - 2015/05/08/ PY - 2015 DA - 2015 May 08 SP - 365 VL - 16 KW - Aristolochic Acids KW - 0 KW - Carcinogens KW - MicroRNAs KW - RNA, Messenger KW - RNA, Neoplasm KW - aristolochic acid I KW - 94218WFP5T KW - Index Medicus KW - Rats KW - Animals KW - Gene Regulatory Networks -- drug effects KW - Proteomics KW - RNA, Messenger -- analysis KW - Molecular Sequence Data KW - Sequence Analysis, RNA KW - MicroRNAs -- analysis KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Male KW - High-Throughput Nucleotide Sequencing KW - Kidney Neoplasms -- genetics KW - Kidney -- metabolism KW - Aristolochic Acids -- toxicity KW - Kidney Neoplasms -- metabolism KW - Kidney -- drug effects KW - Carcinogens -- toxicity KW - Kidney Neoplasms -- etiology KW - RNA, Neoplasm -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686996850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Integrated+microRNA%2C+mRNA%2C+and+protein+expression+profiling+reveals+microRNA+regulatory+networks+in+rat+kidney+treated+with+a+carcinogenic+dose+of+aristolochic+acid.&rft.au=Li%2C+Zhiguang%3BQin%2C+Taichun%3BWang%2C+Kejian%3BHackenberg%2C+Michael%3BYan%2C+Jian%3BGao%2C+Yuan%3BYu%2C+Li-Rong%3BShi%2C+Leming%3BSu%2C+Zhenqiang%3BChen%2C+Tao&rft.aulast=Li&rft.aufirst=Zhiguang&rft.date=2015-05-08&rft.volume=16&rft.issue=&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/10.1186%2Fs12864-015-1516-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-11 N1 - Date created - 2015-06-05 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - GSE54338; GENBANK N1 - SuppNotes - Cited By: Mol Cell. 2007 Jul 6;27(1):91-105 [17612493] Science. 2007 Dec 21;318(5858):1931-4 [18048652] Nature. 2008 Jan 10;451(7175):147-52 [18185580] Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1608-13 [18227514] Nat Biotechnol. 2008 Apr;26(4):462-9 [18362881] Nature. 2008 Apr 17;452(7189):872-6 [18421352] Nat Rev Genet. 2009 Jan;10(1):57-63 [19015660] J Proteomics. 2011 Nov 18;74(12):2745-59 [21884834] J Proteomics. 2011 Nov 18;74(12):2549-53 [22015715] Nephrology (Carlton). 2012 Jul;17(5):522-3 [22725717] Expert Rev Proteomics. 2012 Oct;9(5):549-59 [23194271] Proteomics. 2013 Feb;13(3-4):558-67 [23125164] Neoplasia. 2013 Feb;15(2):218-30 [23441135] Cancer Sci. 2013 Mar;104(3):304-12 [23176581] Ann Intern Med. 2013 Mar 19;158(6):469-77 [23552405] Genet Test Mol Biomarkers. 2013 Nov;17(11):807-13 [23984644] Nucleic Acids Res. 2014 Jan;42(Database issue):D78-85 [24304892] Mutat Res. 2009 Apr 26;663(1-2):1-6 [19428366] Mol Carcinog. 2009 Jun;48(6):479-87 [18942116] Int J Cancer. 2009 Jul 15;125(2):446-52 [19384944] Nucleic Acids Res. 2009 Jul;37(Web Server issue):W68-76 [19433510] Methods Mol Biol. 2009;563:379-98 [19597796] BMC Genomics. 2009;10:365 [19660143] Nature. 2009 Aug 20;460(7258):1011-5 [19587683] Nat Biotechnol. 2009 Sep;27(9):847-50 [19668243] Genome Biol. 2009;10(8):R83 [19682367] Cell Death Differ. 2010 Feb;17(2):193-9 [19461653] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2010 Apr;28(2):89-124 [20552498] Nucleic Acids Res. 2011 Jan;39(Database issue):D163-9 [21071411] Genome Biol. 2010;11(10):R106 [20979621] Curr Mol Med. 2011 Mar;11(2):93-109 [21342132] BMC Bioinformatics. 2014;15 Suppl 1:S4 [24564296] Am J Pathol. 2014 Apr;184(4):996-1009 [24508230] Bioinformatics. 2001 Jun;17(6):509-19 [11395427] Mutagenesis. 2002 Jul;17(4):265-77 [12110620] Pharmazie. 2002 Oct;57(10):686-9 [12426949] Cell. 2003 Jun 13;113(6):673-6 [12809598] Plant Cell. 2003 Nov;15(11):2730-41 [14555699] Nature. 2003 Dec 18;426(6968):845-9 [14685240] Cell. 2004 Jan 23;116(2):281-97 [14744438] Nat Rev Genet. 2004 May;5(5):396-400 [15143321] PLoS Biol. 2004 Nov;2(11):e363 [15502875] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Toxicol Lett. 2006 Sep 10;165(3):250-6 [16764999] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945] Mutat Res. 2006 Dec 1;602(1-2):83-91 [17010389] Trends Mol Med. 2006 Dec;12(12):580-7 [17071139] Cell. 2007 Mar 23;128(6):1105-18 [17382880] Mutat Res. 2007 Jun 1;619(1-2):30-7 [17343880] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s12864-015-1516-2 ER - TY - CPAPER T1 - Novel methods for measuring antibody affinity, epitope diversity, and cross-reactivity in human vaccine trials T2 - 2015 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2015) AN - 1669823281; 6340175 JF - 2015 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2015) AU - Golding, Hana Y1 - 2015/05/08/ PY - 2015 DA - 2015 May 08 KW - Antibodies KW - Cross-reactivity KW - Species diversity KW - Disease control KW - Vaccines KW - Clinical trials KW - Epitopes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2015%29&rft.atitle=Novel+methods+for+measuring+antibody+affinity%2C+epitope+diversity%2C+and+cross-reactivity+in+human+vaccine+trials&rft.au=Golding%2C+Hana&rft.aulast=Golding&rft.aufirst=Hana&rft.date=2015-05-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://immunology2015.org/program/index.html?loc=nav LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - A rapid liquid chromatography determination of free formaldehyde in cod AN - 1727679732; PQ0001423924 AB - A rapid method for the determination of free formaldehyde in cod is described. It uses a simple water extraction of formaldehyde which is then derivatised with 2,4-dinitrophenylhydrazine (DNPH) to form a sensitive and specific chromophore for high-performance liquid chromatography (HPLC) detection. Although this formaldehyde derivative has been widely used in past tissue analysis, this paper describes an improved derivatisation procedure. The formation of the DNPH formaldehyde derivative has been shortened to 2 min and a stabilising buffer has been added to the derivative to increase its stability. The average recovery of free formaldehyde in spiked cod was 63% with an RSD of 15% over the range of 25-200 mg kg super(-1) (n = 48). The HPLC procedure described here was also compared to a commercial qualitative procedure - a swab test for the determination of free formaldehyde in fish. Several positive samples were compared by both methods. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Storey, Joseph M AU - Andersen, Wendy C AU - Heise, Andrea AU - Turnipseed, Sherri B AU - Lohne, Jack AU - Thomas, Terri AU - Madson, Mark AD - US Food and Drug Administration, Animal Drugs Research Center, Denver, CO 80225, USA Y1 - 2015/05/04/ PY - 2015 DA - 2015 May 04 SP - 657 EP - 664 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 5 SN - 1944-0049, 1944-0049 KW - Toxicology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - High-performance liquid chromatography KW - Risk assessment KW - Molecular structure KW - Marine KW - Pollution detection KW - Chromatographic techniques KW - Formaldehyde KW - Chromophores KW - Food contamination KW - Marine fish KW - Food additives KW - Liquid chromatography KW - Commercial species KW - O 5080:Legal/Governmental KW - X 24320:Food Additives & Contaminants KW - Q1 08604:Stock assessment and management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727679732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=A+rapid+liquid+chromatography+determination+of+free+formaldehyde+in+cod&rft.au=Storey%2C+Joseph+M%3BAndersen%2C+Wendy+C%3BHeise%2C+Andrea%3BTurnipseed%2C+Sherri+B%3BLohne%2C+Jack%3BThomas%2C+Terri%3BMadson%2C+Mark&rft.aulast=Storey&rft.aufirst=Joseph&rft.date=2015-05-04&rft.volume=32&rft.issue=5&rft.spage=657&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1020530 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Molecular structure; Marine fish; Food additives; Pollution detection; Chromatographic techniques; Commercial species; Risk assessment; High-performance liquid chromatography; Liquid chromatography; Formaldehyde; Chromophores; Food contamination; Marine DO - http://dx.doi.org/10.1080/19440049.2015.1020530 ER - TY - JOUR T1 - Comparison of X-ray Powder Diffraction and Solid-State Nuclear Magnetic Resonance in Estimating Crystalline Fraction of Tacrolimus in Sustained-Release Amorphous Solid Dispersion and Development of Discriminating Dissolution Method AN - 1837338156; PQ0001392688 AB - The focus of present investigation was to explore X-ray powder diffraction (XRPD) and solid-state nuclear magnetic resonance (ssNMR) techniques for amorphous and crystalline tacrolimus quantification in the sustained-release amorphous solid dispersion (ASD), and to propose discriminating dissolution method that can detect crystalline drug. The ASD and crystalline physical mixture was mixed in various proportions to make sample matrices containing 0%-100% crystalline-amorphous tacrolimus. Partial-least-square regression and principle component regression were applied to the spectral data. Dissolution of the ASD in the US FDA recommended dissolution medium with and without surfactant was performed. R super(2) > 0.99 and slope was close to one for all the models. Root-mean-square of prediction, standard error of prediction, and bias were higher in ssNMR-based models when compared with XRPD data models. Dissolution of the ASD decreased with an increase in the crystalline tacrolimus in the formulations. Furthermore, detection of crystalline tacrolimus in the ASD was progressively masked with an increase in the surfactant level in the dissolution medium. XRPD and ssNMR can be used equally to quantitate the crystalline and amorphous fraction of tacrolimus in the ASD with good accuracy; however, ssNMR data collection time is excessively long, and minimum surfactant level in the dissolution medium maximizes detection of crystalline reversion in the formulation. copyright 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:1777-1786, 2015 JF - Journal of Pharmaceutical Sciences AU - Rahman, Ziyaur AU - Bykadi, Srikant AU - Siddiqui, Akhtar AU - Khan, Mansoor A AD - Division of Product Quality and Research, office of Testing and Research, Center for Drug Evaluation and Research, Food and Drug Administration, Maryland. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 1777 EP - 1786 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 5 SN - 0022-3549, 0022-3549 KW - Toxicology Abstracts KW - Powder KW - Data processing KW - Reversion KW - Data collections KW - Tacrolimus KW - Controlled release KW - Models KW - Ionizing radiation KW - Dissolution KW - N.M.R. KW - Diffraction KW - Drugs KW - Surfactants KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837338156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Comparison+of+X-ray+Powder+Diffraction+and+Solid-State+Nuclear+Magnetic+Resonance+in+Estimating+Crystalline+Fraction+of+Tacrolimus+in+Sustained-Release+Amorphous+Solid+Dispersion+and+Development+of+Discriminating+Dissolution+Method&rft.au=Rahman%2C+Ziyaur%3BBykadi%2C+Srikant%3BSiddiqui%2C+Akhtar%3BKhan%2C+Mansoor+A&rft.aulast=Rahman&rft.aufirst=Ziyaur&rft.date=2015-05-01&rft.volume=104&rft.issue=5&rft.spage=1777&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24400 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Powder; Data processing; Reversion; Tacrolimus; Data collections; Controlled release; Models; Ionizing radiation; Dissolution; N.M.R.; Diffraction; Surfactants; Drugs DO - http://dx.doi.org/10.1002/jps.24400 ER - TY - JOUR T1 - Retrospective cohort study of liver transplantation in the United Kingdom between 1994 and 2010: the impact of hepatitis C infection AN - 1761663319; 2011-880124 AB - Background: Liver transplantation is an important and established treatment option for chronic hepatitis C virus (HCV) related end-stage liver disease (HCV-related ESLD). This study describes trends in elective liver transplantation among persons with HCV-related ESLD. Study design: Retrospective cohort. Methods: Analyses of United Kingdom (UK) Transplant Registry data for the period 1994 to 2010, with follow-up information extending to 2011. Results: Annual registrations for liver transplantation increased linearly and alcoholic liver cirrhosis (2075, 24%) and HCV-related ESLD (1213, 14%) were the most common indications. HCV-related ESLD patients were mainly aged 40-49 years (32%) and 50-59 years (43%); males (76%); and of white ethnicity (74%). Overall, 75% (956/1213) received a liver transplant with a linear increase over the period (OR 1.11, 95% CI 1.08, 1.13). Pre transplant mortality was unchanged (adjusted OR 1.0,95% CI 0.96, 1.05) and post-transplant mortality decreased in both HCV-related (adjusted OR 0.77, 95% CI 0.68, 0.88) and non-HCV-related ESLD (adjusted OR 0.82, 95% CI 0.75, 0.89) patients. Conclusion: The increase in demand for and receipt of liver transplants among persons with HCV-related ESLD requires coordinated efforts to increase not only organ donation, but investment in HCV prevention programmes and improved access to hepatitis C treatment services. [Copyright Elsevier B.V.] JF - Public Health AU - Edeghere, O AU - Verlander, N Q AU - Aboulhab, J AU - Costella, A AU - Harris, H E AU - Balogun, M A AU - Ramsay, M E AD - Field Epidemiology Service, Public Health England, UK obaghe.edeghere@phe.gov.uk Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 509 EP - 516 PB - Elsevier Ltd, The Netherlands VL - 129 IS - 5 SN - 0033-3506, 0033-3506 KW - Hepatitis C Liver transplantation Liver cirrhosis Retrospective studies End stage liver disease Clinical outcome KW - Whites KW - Hepatitis KW - Mortality KW - Investments KW - Donation of organs, tissues, etc. KW - Patients KW - Diseases KW - Ethnic groups KW - United Kingdom KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1761663319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health&rft.atitle=Retrospective+cohort+study+of+liver+transplantation+in+the+United+Kingdom+between+1994+and+2010%3A+the+impact+of+hepatitis+C+infection&rft.au=Edeghere%2C+O%3BVerlander%2C+N+Q%3BAboulhab%2C+J%3BCostella%2C+A%3BHarris%2C+H+E%3BBalogun%2C+M+A%3BRamsay%2C+M+E&rft.aulast=Edeghere&rft.aufirst=O&rft.date=2015-05-01&rft.volume=129&rft.issue=5&rft.spage=509&rft.isbn=&rft.btitle=&rft.title=Public+Health&rft.issn=00333506&rft_id=info:doi/10.1016%2Fj.puhe.2015.01.024 LA - English DB - PAIS Index N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - United Kingdom; Hepatitis; Mortality; Patients; Donation of organs, tissues, etc.; Whites; Ethnic groups; Investments; Diseases DO - http://dx.doi.org/10.1016/j.puhe.2015.01.024 ER - TY - JOUR T1 - Numerical modeling of water spray suppression of conveyor belt fires in a large-scale tunnel AN - 1744681908; PQ0001936446 AB - Conveyor belt fires in an underground mine pose a serious life threat to miners. Water sprinkler systems are usually used to extinguish underground conveyor belt fires, but because of the complex interaction between conveyor belt fires and mine ventilation airflow, more effective engineering designs are needed for the installation of water sprinkler systems. A computational fluid dynamics (CFD) model was developed to simulate the interaction between the ventilation airflow, the belt flame spread, and the water spray system in a mine entry. The CFD model was calibrated using test results from a large-scale conveyor belt fire suppression experiment. Simulations were conducted using the calibrated CFD model to investigate the effects of sprinkler location, water flow rate, and sprinkler activation temperature on the suppression of conveyor belt fires. The sprinkler location and the activation temperature were found to have a major effect on the suppression of the belt fire, while the water flow rate had a minor effect. JF - Process Safety and Environmental Protection AU - Yuan, Liming AU - Smith, Alex C AD - Mine Safety and Health Research, National Institute for Occupational Safety and Health, P.O. Box 18070, Pittsburgh, PA 15236, USA PY - 2015 SP - 93 EP - 101 PB - Institution of Chemical Engineers, Davis Bldg. Rugby Warwickshire CV21 3HQ United Kingdom VL - 95 SN - 0957-5820, 0957-5820 KW - Mechanical & Transportation Engineering Abstracts (MT); Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE); ANTE: Abstracts in New Technologies and Engineering (AN) KW - Conveyor belt fires KW - Computational fluid dynamics KW - Water sprinkler systems KW - Flame spread KW - Ventilation KW - Activation KW - Fires KW - Mathematical models KW - Computer simulation KW - Water flow KW - Sprinklers KW - Belt conveyors KW - Yes:(AN) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1744681908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Process+Safety+and+Environmental+Protection&rft.atitle=Numerical+modeling+of+water+spray+suppression+of+conveyor+belt+fires+in+a+large-scale+tunnel&rft.au=Yuan%2C+Liming%3BSmith%2C+Alex+C&rft.aulast=Yuan&rft.aufirst=Liming&rft.date=2015-05-01&rft.volume=95&rft.issue=&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Process+Safety+and+Environmental+Protection&rft.issn=09575820&rft_id=info:doi/10.1016%2Fj.psep.2015.02.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 23 N1 - Last updated - 2016-02-03 DO - http://dx.doi.org/10.1016/j.psep.2015.02.018 ER - TY - JOUR T1 - Pseudozyma aphidis Induces Salicylic-Acid-Independent Resistance to Clavibacter michiganensis in Tomato Plants AN - 1722168211; PQ0002041288 AB - The ability of plant pathogens to rapidly develop resistance to commonly used pesticides challenges efforts to maximize crop production. Fungal biocontrol agents have become an important alternative to chemical fungicides as a result of environmental concerns regarding conventional pesticides, including resistance issues. The complex mode of action of biocontrol agents reduces the likelihood that pathogens will develop resistance to them. We recently isolated a unique, biologically active isolate of the epiphytic fungus Pseudozyma aphidis. We show that the extracellular metabolites secreted by our P. aphidis isolate can inhibit Xanthomonas campestris pv. vesicatoria, X. campestris pv. campestris, Pseudomonas syringae pv. tomato, Erwinia amylovora, Clavibacter michiganensis, and Agrobacterium tumefaciens in vitro. Moreover, application of Pseudozyma aphidis spores on tomato plants in the greenhouse significantly reduced (by 60%) the incidence of bacterial wilt and canker disease caused by C. michiganensis subsp. michiganensis on those plants as well as disease severity by 35%. Furthermore, infected plants treated with P. aphidis were 25% taller than control infected plants. We found that P. aphidis activates PR1a-and other pathogenesis-related genes in tomato plants-and can trigger an induced-resistance response against C. michiganensis that proceeds in a salicylic-acid-independent manner, as shown using NahG-transgenic tomato plants. JF - Plant Disease AU - Barda, Omer AU - Shalev, Or AU - Alster, Shanee AU - Buxdorf, Kobi AU - Gafni, Aviva AU - Levy, Maggie AD - Department of Plant Pathology and Microbiology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel, maggie.Levy@mail.huji.ac.il PY - 2015 SP - 621 EP - 626 PB - American Phytopathological Society, 3340 Pilot Knob Road St. Paul MN 55121-2097 United States VL - 99 IS - 5 SN - 0191-2917, 0191-2917 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Biological control KW - Canker KW - Plant diseases KW - Metabolites KW - Pathogens KW - Greenhouses KW - Agrobacterium tumefaciens KW - Lycopersicon esculentum KW - Crop production KW - Clavibacter michiganensis KW - Pseudozyma KW - Pesticides KW - Fungicides KW - Xanthomonas campestris KW - Spores KW - Erwinia amylovora KW - Pseudomonas syringae KW - Wilt KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - J 02320:Cell Biology KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722168211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plant+Disease&rft.atitle=Pseudozyma+aphidis+Induces+Salicylic-Acid-Independent+Resistance+to+Clavibacter+michiganensis+in+Tomato+Plants&rft.au=Barda%2C+Omer%3BShalev%2C+Or%3BAlster%2C+Shanee%3BBuxdorf%2C+Kobi%3BGafni%2C+Aviva%3BLevy%2C+Maggie&rft.aulast=Barda&rft.aufirst=Omer&rft.date=2015-05-01&rft.volume=99&rft.issue=5&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Plant+Disease&rft.issn=01912917&rft_id=info:doi/10.1094%2FPDIS-04-14-0377-RE LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Canker; Crop production; Biological control; Plant diseases; Fungicides; Pesticides; Metabolites; Pathogens; Spores; Wilt; Greenhouses; Lycopersicon esculentum; Agrobacterium tumefaciens; Pseudozyma; Clavibacter michiganensis; Xanthomonas campestris; Erwinia amylovora; Pseudomonas syringae DO - http://dx.doi.org/10.1094/PDIS-04-14-0377-RE ER - TY - JOUR T1 - Effects of subchronic exposure of silver nanoparticles on intestinal microbiota and gut-associated immune responses in the ileum of Sprague-Dawley rats AN - 1712572325; PQ0001942528 AB - Silver nanoparticles (AgNP) are widely used for their antibacterial properties. Incorporation of AgNP into food-related products and health supplements represents a potential route for oral exposure to AgNP; however, the effects of such exposure on the gastrointestinal system are mostly unknown. This study evaluated changes in the populations of intestinal-microbiota and intestinal-mucosal gene expression in Sprague-Dawley rats (both male and female) that were gavaged orally with discrete sizes of AgNP (10, 75 and 110 nm) and silver acetate. Doses of AgNP (9, 18 and 36 mg/kg body weight/day) and silver acetate (100, 200 and 400 mg/kg body weight/day) were divided and administered to rats twice daily (~10 h apart) for 13 weeks. The results indicate that AgNP prompted size-and dose-dependent changes to ileal-mucosal microbial populations, as well as, intestinal gene expression and induced an apparent shift in the gut microbiota toward greater proportions of Gram-negative bacteria. DNA-based analyses revealed that exposure to 10nm AgNP and low-dose silver acetate caused a decrease in populations of Firmicutes phyla, along with a decrease in the Lactobacillus genus. Analysis of host gene expression demonstrated that smaller sizes and lower doses of AgNP exposure prompted the decreased expression of important immunomodulatory genes, including MUC3, TLR2, TLR4, GPR43 and FOXP3. Gender-specific effects to AgNP exposure were more prominentforthe gut-associated immune responses. These results indicate that the oral exposure to AgNP alter mucosa-associated microbiota and modulate the gut-associated immune response and the overall homeostasis ofthe intestinal tract. JF - Nanotoxicology AU - Williams, Katherine AU - Milner, Jessica AU - Boudreau, Mary D AU - Gokulan, Kuppan AU - Cerniglia, Carl E AU - Khare, Sangeeta AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, sangeeta.khare@fda.hhs.gov PY - 2015 SP - 279 EP - 289 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 9 IS - 3 SN - 1743-5390, 1743-5390 KW - Immunology Abstracts; Toxicology Abstracts KW - Bacteria KW - microbiome KW - mucosal immunity KW - Food KW - TLR2 protein KW - Firmicutes KW - Homeostasis KW - Ileum KW - Immunomodulation KW - Acetic acid KW - Gene expression KW - Intestinal microflora KW - Lactobacillus KW - Digestive tract KW - Body weight KW - Foxp3 protein KW - Gram-negative bacteria KW - Intestine KW - Immune response KW - nanoparticles KW - Silver KW - TLR4 protein KW - Toll-like receptors KW - F 06910:Microorganisms & Parasites KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1712572325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Effects+of+subchronic+exposure+of+silver+nanoparticles+on+intestinal+microbiota+and+gut-associated+immune+responses+in+the+ileum+of+Sprague-Dawley+rats&rft.au=Williams%2C+Katherine%3BMilner%2C+Jessica%3BBoudreau%2C+Mary+D%3BGokulan%2C+Kuppan%3BCerniglia%2C+Carl+E%3BKhare%2C+Sangeeta&rft.aulast=Williams&rft.aufirst=Katherine&rft.date=2015-05-01&rft.volume=9&rft.issue=3&rft.spage=279&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2014.921346 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Food; TLR2 protein; Ileum; Homeostasis; Acetic acid; Immunomodulation; Gene expression; Intestinal microflora; Digestive tract; Body weight; Foxp3 protein; Gram-negative bacteria; Intestine; Immune response; TLR4 protein; Silver; nanoparticles; Toll-like receptors; Lactobacillus; Firmicutes DO - http://dx.doi.org/10.3109/17435390.2014.921346 ER - TY - JOUR T1 - Intradermal Inactivated Poliovirus Vaccine: A Preclinical Dose-Finding Study AN - 1709176604; PQ0001745366 AB - Intradermal delivery of vaccines has been shown to result in dose sparing. We tested the ability of fractional doses of inactivated poliovirus vaccine (IPV) delivered intradermally to induce levels of serum poliovirus-neutralizing antibodies similar to immunization through the intramuscular route. Immunogenicity of fractional doses of IPV was studied by comparing intramuscular and intradermal immunization of Wistar rats using NanoPass MicronJet600 microneedles. Intradermal delivery of partial vaccine doses induced antibodies at titers comparable to those after immunization with full human dose delivered intramuscularly. The results suggest that intradermal delivery of IPV may lead to dose-sparing effect and reduction of the vaccination cost. JF - Journal of Infectious Diseases AU - Kouiavskaia, Diana AU - Mirochnitchenko, Olga AU - Dragunsky, Eugenia AU - Kochba, Efrat AU - Levin, Yotam AU - Troy, Stephanie AU - Chumakov, Konstantin AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Maryland, konstantin.chumakov@fda.hhs.gov Y1 - 2015/05/01/ PY - 2015 DA - 2015 May 01 SP - 1447 EP - 1450 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 211 IS - 9 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - inactivated poliovirus vaccine KW - intradermal KW - immunogenicity KW - dose sparing KW - Rats KW - Poliovirus KW - Antibodies KW - Infectious diseases KW - Immunogenicity KW - Vaccines KW - Immunization KW - V 22350:Immunology KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709176604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Intradermal+Inactivated+Poliovirus+Vaccine%3A+A+Preclinical+Dose-Finding+Study&rft.au=Kouiavskaia%2C+Diana%3BMirochnitchenko%2C+Olga%3BDragunsky%2C+Eugenia%3BKochba%2C+Efrat%3BLevin%2C+Yotam%3BTroy%2C+Stephanie%3BChumakov%2C+Konstantin&rft.aulast=Kouiavskaia&rft.aufirst=Diana&rft.date=2015-05-01&rft.volume=211&rft.issue=9&rft.spage=1447&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu624 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Antibodies; Immunogenicity; Vaccines; Rats; Poliovirus; Infectious diseases; Immunization DO - http://dx.doi.org/10.1093/infdis/jiu624 ER - TY - JOUR T1 - Intention of Nursing Students to Work in Geriatrics AN - 1708853440 AB - The current study examined factors related to nursing students' intention to work in geriatrics upon graduation. A cross-sectional, descriptive design was used. A random sample of 200 nursing students completed a questionnaire based on the Theory of Planned Behavior and Kogan's Attitudes Toward Old People Scale. Participants expressed low intention to work in geriatrics upon graduation. Results of a multiple linear regression indicated that students' attitudes toward working in geriatrics and normative and control beliefs were found to be predictors of this intention. Additionally, male and religious students were more inclined to work in geriatrics. The current study indicated that nursing students' attitudes toward working in geriatrics were significantly predictive of their intention to work in this field upon graduation. [Res Gerontol Nurs. 2015; 8(3):140-147.] JF - Research in Gerontological Nursing AU - Ben Natan, Merav AU - Danino, Sharon AU - Freundlich, Nelli AU - Barda, Ayelet AU - Yosef, Racheli Mor Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 140 EP - 147 CY - Thorofare PB - SLACK INCORPORATED VL - 8 IS - 3 SN - 19404921 KW - Gerontology And Geriatrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1708853440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+Gerontological+Nursing&rft.atitle=Intention+of+Nursing+Students+to+Work+in+Geriatrics&rft.au=Ben+Natan%2C+Merav%3BDanino%2C+Sharon%3BFreundlich%2C+Nelli%3BBarda%2C+Ayelet%3BYosef%2C+Racheli+Mor&rft.aulast=Ben+Natan&rft.aufirst=Merav&rft.date=2015-05-01&rft.volume=8&rft.issue=3&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Research+in+Gerontological+Nursing&rft.issn=19404921&rft_id=info:doi/10.3928%2F19404921-20150219-03 LA - English DB - ProQuest Central N1 - Copyright - Copyright 2015, SLACK Incorporated N1 - Last updated - 2016-04-02 DO - http://dx.doi.org/10.3928/19404921-20150219-03 ER - TY - JOUR T1 - Assessment of benefits and risks in development of targeted therapies for cancer--The view of regulatory authorities. AN - 1691281134; 25481691 AB - Drug licensing and approval decisions involve the balancing of benefits against the risks (harms) in the presence of uncertainty. Typically, the benefits are estimated from primary efficacy endpoints from confirmatory (phase III) clinical trials although exceptions where promising early data from single-arm studies have led to accelerated approvals are not uncommon, particularly for cancer drugs. The challenge for regulators is to balance early evidence of efficacy that might support approval versus the need to establish clinical benefit based on conclusive evidence. Targeted agents offer the promise that knowledge about the mechanism of the disease will help identify patients with tumors likely to respond, resulting in higher efficacy and less toxicity, and earlier regulatory decisions based on convincing evidence of clinical benefit. In this paper, we describe methods and examples of benefit-risk assessment of targeted drugs, recent initiatives from EMA and FDA on improving communication about benefits and risks, and discuss future steps. Published by Elsevier B.V. JF - Molecular oncology AU - Pignatti, Francesco AU - Jonsson, Bertil AU - Blumenthal, Gideon AU - Justice, Robert AD - European Medicines Agency (EMA), London, United Kingdom. Electronic address: francesco.pignatti@ema.europa.eu. ; Läkemedelsverket, Uppsala, Sweden. ; Food and Drug Administration (FDA), Silver Spring, MD, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 1034 EP - 1041 VL - 9 IS - 5 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Benefit-risk balance KW - Drug regulation KW - Targeted therapies KW - Humans KW - Risk Assessment KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691281134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+oncology&rft.atitle=Assessment+of+benefits+and+risks+in+development+of+targeted+therapies+for+cancer--The+view+of+regulatory+authorities.&rft.au=Pignatti%2C+Francesco%3BJonsson%2C+Bertil%3BBlumenthal%2C+Gideon%3BJustice%2C+Robert&rft.aulast=Pignatti&rft.aufirst=Francesco&rft.date=2015-05-01&rft.volume=9&rft.issue=5&rft.spage=1034&rft.isbn=&rft.btitle=&rft.title=Molecular+oncology&rft.issn=1878-0261&rft_id=info:doi/10.1016%2Fj.molonc.2014.10.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-19 N1 - Date created - 2015-04-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.molonc.2014.10.003 ER - TY - JOUR T1 - Emergent and evolving antimicrobial resistance cassettes in community-associated fusidic acid and meticillin-resistant Staphylococcus aureus AN - 1683355066; PQ0001567602 AB - times Resistance to fusidic acid rose among meticillin-resistant Staphylococcus aureus (MRSA) during the 2000s. Fusidic acid is a topical and systemic antimicrobial used for the treatment of staphylococcal infections in hospitals and the community. Sales of fusidic acid and resistance rates among meticillin-resistant Staphylococcus aureus (MRSA) doubled between 1990 and 2001. For the following decade, fusidic acid resistance rates among isolates from Addenbrooke's Hospital (Cambridge, UK) were compared with national resistance rates from MRSA bacteraemia surveillance data and with antimicrobial sales data. Sales of fusidic acid remained relatively constant between 2002 and 2012, whilst fusidic acid resistance increased two- and four-fold in MRSA bacteraemias nationally and in MRSA isolates from Cambridge, respectively. A subgroup of MRSA resistant only to fusidic acid increased after 2006 by 5-fold amongst bacteraemias nationally and 17-fold (to 7.7% in 2012) amongst Cambridge MRSA isolates. All of the available local isolates from 2011 to 2012 (n = 23) were acquired in the community, were not related epidemiologically and belonged to multilocus sequence typing (MLST) groups ST1, 5, 8, 45 or 149 as revealed from analysis of whole-genome sequence data. All harboured the fusC gene on one of six distinct staphylococcal cassette chromosome (SCC) elements, four of which were dual-resistance chimeras that encoded beta -lactam and fusidic acid resistance. In summary, fusidic acid-resistant MRSA increased in prevalence during the 2000s with notable rises after 2006. The development of chimeric cassettes that confer dual resistance to beta -lactams and fusidic acid demonstrates that the genetics underpinning resistance in community-associated MRSA are evolving. JF - International Journal of Antimicrobial Agents AU - Ellington, Matthew J AU - Reuter, Sandra AU - Harris, Simon R AU - Holden, Matthew TG AU - Cartwright, Edward J AU - Greaves, Daniel AU - Gerver, Sarah M AU - Hope, Russell AU - Brown, Nicholas M AU - Torok, MEstee AU - Parkhill, Julian AU - Koser, Claudio U AU - Peacock, Sharon J AD - aPublic Health England, Microbiology Services Division, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QW, UK, matthew.ellington@phe.gov.uk Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 477 EP - 484 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 45 IS - 5 SN - 0924-8579, 0924-8579 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - CA-MRSA KW - Antimicrobial resistance KW - Surveillance KW - SCC genomics KW - Data processing KW - Drug resistance KW - Bacteremia KW - Infection KW - Antimicrobial agents KW - multilocus sequence typing KW - Chimeras KW - Chromosomes KW - Fusidic acid KW - beta -Lactam antibiotics KW - Staphylococcus aureus KW - Hospitals KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683355066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Emergent+and+evolving+antimicrobial+resistance+cassettes+in+community-associated+fusidic+acid+and+meticillin-resistant+Staphylococcus+aureus&rft.au=Ellington%2C+Matthew+J%3BReuter%2C+Sandra%3BHarris%2C+Simon+R%3BHolden%2C+Matthew+TG%3BCartwright%2C+Edward+J%3BGreaves%2C+Daniel%3BGerver%2C+Sarah+M%3BHope%2C+Russell%3BBrown%2C+Nicholas+M%3BTorok%2C+MEstee%3BParkhill%2C+Julian%3BKoser%2C+Claudio+U%3BPeacock%2C+Sharon+J&rft.aulast=Ellington&rft.aufirst=Matthew&rft.date=2015-05-01&rft.volume=45&rft.issue=5&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2015.01.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Chimeras; Chromosomes; Data processing; Fusidic acid; Drug resistance; beta -Lactam antibiotics; Bacteremia; Infection; multilocus sequence typing; Antimicrobial agents; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1016/j.ijantimicag.2015.01.009 ER - TY - JOUR T1 - Seroprevalence of Antibody-Mediated, Complement-Dependent Opsonophagocytic Activity against Neisseria meningitidis Serogroup B in England AN - 1683348650; PQ0001539756 AB - The correlate of protection for the licensure of meningococcal vaccines is serum bactericidal activity. However, evidence indicates that a complex situation and other mechanisms, such as antibody-mediated, complement-dependent opsonophagocytosis (OP), may play a role in protection and should be investigated in order to understand immunity to this disease. In this study, a high-throughput flow cytometric opsonophagocytic assay (OPA) was optimized. The assay measures the presence of killed fluorescently labeled Neisseria meningitidis within human granulocytes (differentiated HL60 cells) by flow cytometry, using IgG-depleted pooled human plasma as an exogenous source of complement. This method was found to be reliable and correlated with the results of an opsonophagocytic killing assay. The OPA was used to measure OP activity in 1,878 serum samples from individuals ranging from 0 to 99 years of age against N. meningitidis strain NZ98/254 (B:4:P1.7-2,4). The levels of OP activity in individual serum samples varied greatly. OP activity showed an initial peak in the 6- to 12-month age group corresponding to a peak in disease incidence. The OP activity dropped in childhood until the late teenage years, although there was still a higher percentage of individuals with OP activity than with protective bactericidal antibody titers. OP activity reached a peak in the 30- to 39-year age group and then declined. This later peak in OP activity did not coincide with the young adults in whom peak serum bactericidal activity and disease incidence occurred. The demonstration of OP activity when disease incidence is low and when protective bactericidal antibody titers are not detected may indicate a role for OP in protection from meningococcal disease in these age groups. JF - Clinical and Vaccine Immunology AU - Humphries, Holly E AU - Brookes, Charlotte AU - Allen, Lauren AU - Kuisma, Eeva AU - Gorringe, Andrew AU - Taylor, Stephen Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 503 EP - 509 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 22 IS - 5 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Flow cytometry KW - Leukocytes (granulocytic) KW - Age KW - Antibodies KW - meningococcal disease KW - Serum bactericidal activity KW - opsonophagocytosis KW - Neisseria meningitidis KW - Vaccines KW - Immunity KW - Children KW - F 06905:Vaccines KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683348650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Seroprevalence+of+Antibody-Mediated%2C+Complement-Dependent+Opsonophagocytic+Activity+against+Neisseria+meningitidis+Serogroup+B+in+England&rft.au=Humphries%2C+Holly+E%3BBrookes%2C+Charlotte%3BAllen%2C+Lauren%3BKuisma%2C+Eeva%3BGorringe%2C+Andrew%3BTaylor%2C+Stephen&rft.aulast=Humphries&rft.aufirst=Holly&rft.date=2015-05-01&rft.volume=22&rft.issue=5&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00100-15 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 38 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Leukocytes (granulocytic); Antibodies; Age; meningococcal disease; Serum bactericidal activity; opsonophagocytosis; Immunity; Vaccines; Children; Neisseria meningitidis DO - http://dx.doi.org/10.1128/CVI.00100-15 ER - TY - JOUR T1 - Flavoring exposure in food manufacturing AN - 1680461084; PQ0001495816 AB - Flavorings are substances that alter or enhance the taste of food. Workers in the food-manufacturing industry, where flavorings are added to many products, may be exposed to any number of flavoring compounds. Although thousands of flavoring substances are in use, little is known about most of these in terms of worker health effects, and few have occupational exposure guidelines. Exposure assessment surveys were conducted at nine food production facilities and one flavor manufacturer where a total of 105 area and 74 personal samples were collected for 13 flavoring compounds including five ketones, five aldehydes, and three acids. The majority of the samples were below the limit of detection (LOD) for most compounds. Diacetyl had eight area and four personal samples above the LOD, whereas 2,3-pentanedione had three area samples above the LOD. The detectable values ranged from 25-3124 ppb and 15-172 ppb for diacetyl and 2,3-pentanedione respectively. These values exceed the proposed National Institute for Occupational Safety and Health (NIOSH) recommended exposure limit for these compounds. The aldehydes had the most detectable samples, with each of them having >50% of the samples above the LOD. Acetaldehyde had all but two samples above the LOD, however, these samples were below the OSHA PEL. It appears that in the food-manufacturing facilities surveyed here, exposure to the ketones occurs infrequently, however levels above the proposed NIOSH REL were found. Conversely, aldehyde exposure appears to be ubiquitous. JF - Journal of Exposure Science and Environmental Epidemiology AU - Curwin, Brian D AU - Deddens, Jim A AU - McKernan, Lauralynn T AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 324 EP - 333 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 25 IS - 3 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Federal regulations KW - Safety regulations KW - Food industry KW - Food KW - Acetaldehyde KW - Guidelines KW - Occupational safety KW - Flavorings KW - Taste KW - Diacetyl KW - Ketones KW - Acids KW - Aldehydes KW - Occupational exposure KW - Food production KW - ketones KW - X 24320:Food Additives & Contaminants KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680461084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Flavoring+exposure+in+food+manufacturing&rft.au=Curwin%2C+Brian+D%3BDeddens%2C+Jim+A%3BMcKernan%2C+Lauralynn+T&rft.aulast=Curwin&rft.aufirst=Brian&rft.date=2015-05-01&rft.volume=25&rft.issue=3&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2014.52 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Food industry; Acids; Acetaldehyde; Food; Flavorings; Taste; Aldehydes; Diacetyl; Occupational exposure; ketones; Federal regulations; Safety regulations; Ketones; Occupational safety; Guidelines; Food production DO - http://dx.doi.org/10.1038/jes.2014.52 ER - TY - JOUR T1 - Persistent organic pollutants (POPs) and fibroids: results from the ENDO study AN - 1680461065; PQ0001495811 AB - To evaluate the association between persistent organic pollutants (POPs) and uterine fibroids, we used previously collected data from a cohort of women aged 18-44 years undergoing laparoscopy or laparotomy at 14 participating hospital surgical centers (n=473). POP concentrations were measured in omental fat and serum. Presence of fibroids was defined on the basis of a postoperative diagnosis (n=99). Odds ratios (OR) and 95% confidence interval (CI) for each POP by biologic medium were estimated using unconditional logistic regression adjusted for identified covariates. Concentrations were higher in omental fat than in serum for all POPs. Serum p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) was the only POP associated with fibroids (per 1-SD increase in log-transformed p,p'-DDE OR (95% CI): 1.37 (1.05-1.80)). In analyses excluding women diagnosed with endometriosis, a number of polychlorinated biphenyls (PCBs) measured in omental fat were associated with fibroids (PCB 99: 1.64 (1.08, 2.49); PCB 138: 1.64 (1.03, 2.59); PCB 146: 1.54 (1.01, 2.37); PCB 153: 1.88 (1.12, 3.13); PCB 196: 1.60 (1.02, 2.51); PCB 206: 1.52 (1.01, 2.29)). Although exploratory, our study suggests that PCBs may be associated with fibroids in the absence of other gynecologic disorders such as endometriosis, but the associations varied by biologic media with more POPs emerging when quantified in fat. JF - Journal of Exposure Science and Environmental Epidemiology AU - Trabert, Britton AU - Chen, Zhen AU - Kannan, Kurunthachalam AU - Peterson, C Matthew AU - Pollack, Anna Z AU - Sun, Liping AU - Buck Louis, Germaine M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 278 EP - 285 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 25 IS - 3 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts; Pollution Abstracts; Health & Safety Science Abstracts; Environment Abstracts KW - Uterus KW - Data processing KW - Laparoscopy KW - Endometriosis KW - polychlorinated biphenyls KW - Pollutants KW - Surgery KW - Persistent organic pollutants KW - PCB compounds KW - PCB KW - Hospitals KW - H 12000:Epidemiology and Public Health KW - X 24350:Industrial Chemicals KW - P 6000:TOXICOLOGY AND HEALTH KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680461065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=Persistent+organic+pollutants+%28POPs%29+and+fibroids%3A+results+from+the+ENDO+study&rft.au=Trabert%2C+Britton%3BChen%2C+Zhen%3BKannan%2C+Kurunthachalam%3BPeterson%2C+C+Matthew%3BPollack%2C+Anna+Z%3BSun%2C+Liping%3BBuck+Louis%2C+Germaine+M&rft.aulast=Trabert&rft.aufirst=Britton&rft.date=2015-05-01&rft.volume=25&rft.issue=3&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fjes.2014.31 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Uterus; Data processing; polychlorinated biphenyls; Pollutants; Laparoscopy; Endometriosis; PCB; Hospitals; Surgery; Persistent organic pollutants; PCB compounds DO - http://dx.doi.org/10.1038/jes.2014.31 ER - TY - JOUR T1 - Effect of therapeutic femtosecond laser pulse energy, repetition rate, and numerical aperture on laser-induced second and third harmonic generation in corneal tissue AN - 1680440446; PQ0001502738 AB - Clinical therapy incorporating femtosecond laser (FSL) devices is a quickly growing field in modern biomedical technology due to their precision and ability to generate therapeutic effects with substantially less laser pulse energy. FSLs have the potential to produce nonlinear optical effects such as harmonic generation (HG), especially in tissues with significant nonlinear susceptibilities such as the cornea. HG in corneal tissue has been demonstrated in nonlinear harmonic microscopy using low-power FSLs. Furthermore, the wavelength ranges of harmonic spectral emissions generated in corneal tissues are known to be phototoxic above certain intensities. We have investigated how the critical FSL parameters pulse energy, pulse repetition rate, and numerical aperture influence both second (SHG) and third harmonic generation (THG) in corneal tissue. Experimental results demonstrated corresponding increases in HG intensity with increasing repetition rate and numerical aperture. HG duration decreased with increasing repetition rate and pulse energy. The data also demonstrated a significant difference in HG between FSL parameters representing the two most common classes of FSL therapeutic devices. JF - Lasers in Medical Science AU - Calhoun, William R AU - Ilev, Ilko K AD - Optical Therapeutics and Medical Nanophotonics Laboratory, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA, william.calhoun@fda.hhs.gov Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 1341 EP - 1346 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 30 IS - 4 SN - 0268-8921, 0268-8921 KW - Biotechnology and Bioengineering Abstracts KW - Repetition KW - Data processing KW - Cornea KW - Energy KW - Microscopy KW - Lasers KW - Wavelength KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680440446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lasers+in+Medical+Science&rft.atitle=Effect+of+therapeutic+femtosecond+laser+pulse+energy%2C+repetition+rate%2C+and+numerical+aperture+on+laser-induced+second+and+third+harmonic+generation+in+corneal+tissue&rft.au=Calhoun%2C+William+R%3BIlev%2C+Ilko+K&rft.aulast=Calhoun&rft.aufirst=William&rft.date=2015-05-01&rft.volume=30&rft.issue=4&rft.spage=1341&rft.isbn=&rft.btitle=&rft.title=Lasers+in+Medical+Science&rft.issn=02688921&rft_id=info:doi/10.1007%2Fs10103-015-1726-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 39 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Repetition; Data processing; Cornea; Energy; Microscopy; Lasers; Wavelength DO - http://dx.doi.org/10.1007/s10103-015-1726-5 ER - TY - JOUR T1 - Estimating the Benefits of Public Health Policies that Reduce Harmful Consumption AN - 1680436073; PQ0001425934 AB - For products such as tobacco and junk food, where policy interventions are often designed to decrease consumption, affected consumers gain utility from improvements in lifetime health and longevity but also lose utility associated with the activity of consuming the product. In the case of anti-smoking policies, even though published estimates of gross health and longevity benefits are up to 900 times higher than the net consumer benefits suggested by a more direct willingness-to-pay estimation approach, there is little recognition in the cost-benefit and cost-effectiveness literature that gross estimates will overstate intrapersonal welfare improvements when utility losses are not netted out. This paper presents a general framework for analyzing policies that are designed to reduce inefficiently high consumption and provides a rule of thumb for the relationship between net and gross consumer welfare effects: where there exists a plausible estimate of the tax that would allow consumers to fully internalize health costs, the ratio of the tax to the per-unit long-term cost can provide an upper bound on the ratio of net to gross benefits. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Health Economics AU - Ashley, Elizabeth M AU - Nardinelli, Clark AU - Lavaty, Rosemarie A AD - Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 617 EP - 624 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 24 IS - 5 SN - 1057-9230, 1057-9230 KW - Health & Safety Science Abstracts KW - Taxation KW - Willingness to pay KW - USA KW - Economics KW - Tobacco KW - Intervention KW - Longevity KW - Cost benefit analysis KW - Public health KW - H 9000:Consumer and Recreation Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680436073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Estimating+the+Benefits+of+Public+Health+Policies+that+Reduce+Harmful+Consumption&rft.au=Ashley%2C+Elizabeth+M%3BNardinelli%2C+Clark%3BLavaty%2C+Rosemarie+A&rft.aulast=Ashley&rft.aufirst=Elizabeth&rft.date=2015-05-01&rft.volume=24&rft.issue=5&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.3040 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Willingness to pay; Taxation; Economics; Tobacco; Intervention; Cost benefit analysis; Longevity; Public health; USA DO - http://dx.doi.org/10.1002/hec.3040 ER - TY - JOUR T1 - Continued progress in developing the Pig-a gene mutation assay. AN - 1680178983; 25934984 AB - The Pig-a assay has shown promise as a regulatory assay for evaluating in vivo gene mutation. A recent International Workshop on Genotoxicity Testing workgroup discussed the state of the assay and identified several knowledge gaps in assay development. This Mutagenesis Special Topic includes a collection of reports that addresses some of these knowledge gaps, including identifying the mutations responsible for the Pig-a mutant phenotype, the effect of sex on the response, probing the robustness of the assay and expanding the number of agents tested in the assay, especially agents expected to yield negative responses. © The Author 2015. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. JF - Mutagenesis AU - Heflich, Robert H AU - Dobrovolsky, Vasily N AU - Dertinger, Stephen D AD - U.S. Food and Drug Administration/National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, Jefferson, AR 72079, USA robert.heflich@fda.hhs.gov. ; U.S. Food and Drug Administration/National Center for Toxicological Research, Division of Genetic and Molecular Toxicology, Jefferson, AR 72079, USA. ; Litron Laboratories, Rochester, NY 14623, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 313 EP - 314 VL - 30 IS - 3 KW - GPI-Linked Proteins KW - 0 KW - Membrane Proteins KW - phosphatidylinositol glycan-class A protein KW - Index Medicus KW - Animals KW - GPI-Linked Proteins -- biosynthesis KW - Humans KW - Genes, Reporter KW - Mutation KW - Membrane Proteins -- genetics KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680178983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Continued+progress+in+developing+the+Pig-a+gene+mutation+assay.&rft.au=Heflich%2C+Robert+H%3BDobrovolsky%2C+Vasily+N%3BDertinger%2C+Stephen+D&rft.aulast=Heflich&rft.aufirst=Robert&rft.date=2015-05-01&rft.volume=30&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgeu082 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-16 N1 - Date created - 2015-05-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/geu082 ER - TY - GEN T1 - Alternatives to PFASs: perspectives on the science. AN - 1677887250; 25932670 JF - Environmental health perspectives AU - Birnbaum, Linda S AU - Grandjean, Philippe Y1 - 2015/05// PY - 2015 DA - May 2015 SP - A104 EP - A105 VL - 123 IS - 5 KW - Fluorocarbons KW - 0 KW - Surface-Active Agents KW - Index Medicus KW - Fluorocarbons -- chemistry KW - Animals KW - Environmental Health KW - Humans KW - Fluorocarbons -- toxicity KW - Surface-Active Agents -- chemistry KW - Surface-Active Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677887250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Environmental+health+perspectives&rft.atitle=Alternatives+to+PFASs%3A+perspectives+on+the+science.&rft.au=Birnbaum%2C+Linda+S%3BGrandjean%2C+Philippe&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2015-05-01&rft.volume=123&rft.issue=5&rft.spage=A104&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1509944 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-04 N1 - Date created - 2015-05-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 2004 Jan;112(1):9-17 [14698924] Environ Sci Technol. 2010 Dec 15;44(24):9244-9 [21062050] Integr Environ Assess Manag. 2011 Oct;7(4):513-41 [21793199] Environ Health Perspect. 2013 Jan;121(1):A9 [23287533] Environ Int. 2013 Oct;60:242-8 [24660230] Environ Health Perspect. 2015 Jul;123(7):643-50 [25775505] Public Health Rep. 2014 Nov-Dec;129(6):482-5 [25364048] Sci Total Environ. 2015 Feb 1;505:981-91 [25461098] Environ Int. 2015 Feb;75:172-9 [25461427] Environ Health Perspect. 2015 May;123(5):A107-11 [25932614] Environ Health Perspect. 2015 May;123(5):A112-3 [25933200] Chemosphere. 2014 Nov;114:337-9 [24938172] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1509944 ER - TY - JOUR T1 - Characterisation of novel mutations involved in quinolone resistance in Escherichia coli isolated from imported shrimp. AN - 1675873336; 25631675 AB - Fifty-five nalidixic acid-resistant Escherichia coli strains were isolated from imported shrimp. Purified PCR amplicons of gyrA, gyrB, parC and parE from the template DNA of all isolates were sequenced and analysed for point mutations that confer resistance to nalidixic acid and ciprofloxacin. Point mutations in the quinolone resistance-determining regions (QRDRs) of GyrA at positions 68, 83 and 87 and in ParC at positions 80 and 84 as well as in the non-QRDR of GyrA at positions 112, 127, 128 and 154 along with point mutations in parE at position 476 conferred resistance to these antibiotics. Computational modelling and analysis of the different point mutations and their role in the enhanced resistance to these antibiotics indicated that only mutation at codons 83 (Ser→Ile) and 87 (Asp→Asn) played a vital role in increasing the minimum inhibitory concentration (MIC) to these drugs compared with other mutations. Ethidium bromide experiments indicated higher efflux pump activities in quinolone-resistant E. coli strains compared with their quinolone-sensitive counterparts. Class 1 integrons measuring 0.7-2.3kb were amplified and sequenced from the template DNA of the isolates. Sequence analysis of the 2.0kb and 1.7kb integrons indicated the presence of resistance determinants for trimethoprim (dfrA12 and dfrA17) and aminoglycosides (aadA2 and aadA5). These results indicate that use of nalidixic acid, ciprofloxacin and other antibiotics in shrimp aquaculture ponds may select E. coli resistant to these antibiotics and that imported shrimp is a reservoir of multiple antibiotic-resistant E. coli. Published by Elsevier B.V. JF - International journal of antimicrobial agents AU - Nawaz, Mohamed AU - Sung, Kidon AU - Kweon, Ohgew AU - Khan, Saeed AU - Nawaz, Samia AU - Steele, Roger AD - Division of Microbiology, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA. Electronic address: Mohamed.Nawaz@fda.hhs.gov. ; Division of Microbiology, US Food and Drug Administration, National Center for Toxicological Research, Jefferson, AR 72079, USA. ; Hendrix College, Conway, AR 72032, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 471 EP - 476 VL - 45 IS - 5 KW - Anti-Bacterial Agents KW - 0 KW - Escherichia coli Proteins KW - Quinolones KW - Nalidixic Acid KW - 3B91HWA56M KW - Ciprofloxacin KW - 5E8K9I0O4U KW - Index Medicus KW - Escherichia coli KW - Quinolone resistance KW - Imported shrimp KW - Nalidixic Acid -- pharmacology KW - Models, Molecular KW - Seafood -- microbiology KW - Sequence Analysis, DNA KW - Biological Transport, Active KW - Selection, Genetic KW - Ciprofloxacin -- pharmacology KW - Escherichia coli Proteins -- chemistry KW - Polymerase Chain Reaction KW - Point Mutation KW - Microbial Sensitivity Tests KW - Escherichia coli Proteins -- genetics KW - Protein Conformation KW - Drug Resistance, Bacterial KW - Escherichia coli -- drug effects KW - Anti-Bacterial Agents -- pharmacology KW - Escherichia coli -- genetics KW - Mutation, Missense KW - Quinolones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675873336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+antimicrobial+agents&rft.atitle=Characterisation+of+novel+mutations+involved+in+quinolone+resistance+in+Escherichia+coli+isolated+from+imported+shrimp.&rft.au=Nawaz%2C+Mohamed%3BSung%2C+Kidon%3BKweon%2C+Ohgew%3BKhan%2C+Saeed%3BNawaz%2C+Samia%3BSteele%2C+Roger&rft.aulast=Nawaz&rft.aufirst=Mohamed&rft.date=2015-05-01&rft.volume=45&rft.issue=5&rft.spage=471&rft.isbn=&rft.btitle=&rft.title=International+journal+of+antimicrobial+agents&rft.issn=1872-7913&rft_id=info:doi/10.1016%2Fj.ijantimicag.2014.11.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-08 N1 - Date created - 2015-04-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ijantimicag.2014.11.010 ER - TY - JOUR T1 - In vivo genotoxicity of estragole in male F344 rats. AN - 1675167953; 25361439 AB - Estragole, a naturally occurring constituent of various herbs and spices, is a rodent liver carcinogen which requires bio-activation. To further understand the mechanisms underlying its carcinogenicity, genotoxicity was assessed in F344 rats using the comet, micronucleus (MN), and DNA adduct assays together with histopathological analysis. Oxidative damage was measured using human 8-oxoguanine-DNA-N-glycosylase (hOGG1) and EndonucleaseIII (EndoIII)-modified comet assays. Results with estragole were compared with the structurally related genotoxic carcinogen, safrole. Groups of seven-week-old male F344 rats received corn oil or corn oil containing 300, 600, or 1,000 mg/kg bw estragole and 125, 250, or 450 mg/kg bw safrole by gavage at 0, 24, and 45 hr and terminated at 48 hr. Estragole-induced dose-dependent increases in DNA damage following EndoIII or hOGG1 digestion and without enzyme treatment in liver, the cancer target organ. No DNA damage was detected in stomach, the non-target tissue for cancer. No elevation of MN was observed in reticulocytes sampled from peripheral blood. Comet assays, both without digestion or with either EndoIII or hOGG1 digestion, also detected DNA damage in the liver of safrole-dosed rats. No DNA damage was detected in stomach, nor was MN elevated in peripheral blood following dosing with safrole suggesting that, as far both safrole and estragole, oxidative damage may contribute to genotoxicity. Taken together, these results implicate multiple mechanisms of estragole genotoxicity. DNA damage arises from chemical-specific interaction and is also mediated by oxidative species. © 2014 Crown copyright. JF - Environmental and molecular mutagenesis AU - Ding, Wei AU - Levy, Dan D AU - Bishop, Michelle E AU - Pearce, Mason G AU - Davis, Kelly J AU - Jeffrey, Alan M AU - Duan, Jian-Dong AU - Williams, Gary M AU - White, Gene A AU - Lyn-Cook, Lascelles E AU - Manjanatha, Mugimane G AD - Division of Genetic and Molecular Toxicology, US FDA/National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 356 EP - 365 VL - 56 IS - 4 KW - Anisoles KW - 0 KW - DNA Adducts KW - estragole KW - 9NIW07V3ET KW - DNA Glycosylases KW - EC 3.2.2.- KW - oxoguanine glycosylase 1, human KW - Safrole KW - RSB34337V9 KW - Index Medicus KW - cell proliferation KW - inflammation KW - In vivo comet assay KW - oxidative DNA damage KW - direct DNA damage KW - Animals KW - Liver -- pathology KW - Kidney -- pathology KW - Kidney -- drug effects KW - Comet Assay -- methods KW - Stomach -- drug effects KW - Safrole -- toxicity KW - DNA Damage -- drug effects KW - Rats, Inbred F344 KW - Micronucleus Tests KW - Liver -- drug effects KW - DNA Glycosylases -- metabolism KW - Male KW - Mutagenicity Tests -- methods KW - Anisoles -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1675167953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=In+vivo+genotoxicity+of+estragole+in+male+F344+rats.&rft.au=Ding%2C+Wei%3BLevy%2C+Dan+D%3BBishop%2C+Michelle+E%3BPearce%2C+Mason+G%3BDavis%2C+Kelly+J%3BJeffrey%2C+Alan+M%3BDuan%2C+Jian-Dong%3BWilliams%2C+Gary+M%3BWhite%2C+Gene+A%3BLyn-Cook%2C+Lascelles+E%3BManjanatha%2C+Mugimane+G&rft.aulast=Ding&rft.aufirst=Wei&rft.date=2015-05-01&rft.volume=56&rft.issue=4&rft.spage=356&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.21918 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-30 N1 - Date created - 2015-04-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/em.21918 ER - TY - JOUR T1 - Does household use of biomass fuel cause lung cancer? A systematic review and evaluation of the evidence for the GBD 2010 study. AN - 1673372021; 25758120 AB - Around 2.4 billion people use traditional biomass fuels for household cooking or heating. In 2006, the International Agency for Research on Cancer (IARC) concluded emissions from household coal combustion are a Group 1 carcinogen, while those from biomass were categorised as 2A due to epidemiologic limitations. This review updates the epidemiologic evidence and provides risk estimates for the 2010 Global Burden of Disease study. Searches were conducted of 10 databases to July 2012 for studies of clinically diagnosed or pathologically confirmed lung cancer associated with household biomass use for cooking and/or heating. Fourteen eligible studies of biomass cooking or heating were identified: 13 had independent estimates (12 cooking only), all were case-control designs and provided 8221 cases and 11 342 controls. The ORs for lung cancer risk with biomass for cooking and/or heating were OR 1.17 (95% CI 1.01 to 1.37) overall, and 1.15 (95% CI 0.97 to 1.37) for cooking only. Publication bias was not detected, but more than half the studies did not explicitly describe a clean reference category. Sensitivity analyses restricted to studies with adequate adjustment and a clean reference category found ORs of 1.21 (95% CI 1.05 to 1.39) for men (two reports, compiling five studies) and 1.95 (95% CI 1.16 to 3.27) for women (five reports, compiling eight studies). Exposure-response evidence was seen for men, and higher risk for women in developing compared with developed countries, consistent with higher exposures in the former. There is now stronger evidence for biomass fuel use causing lung cancer, but future studies need better exposure assessment to strengthen exposure-response evidence. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Thorax AU - Bruce, Nigel AU - Dherani, Mukesh AU - Liu, Rui AU - Hosgood, H Dean AU - Sapkota, Amir AU - Smith, Kirk R AU - Straif, Kurt AU - Lan, Qing AU - Pope, Daniel AD - Department of Public Health and Policy, University of Liverpool, Liverpool, UK. ; Environmental Health Sciences, School of Public Health, University of California Berkeley, California, USA. ; Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Division of Epidemiology, Albert Einstein College of Medicine, Bronx, New York, USA. ; Maryland Institute for Applied Environmental Health, University of Maryland, School of Public Health, College Park, Maryland, USA. ; International Agency for Research on Cancer, Lyon, France. ; Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 433 EP - 441 VL - 70 IS - 5 KW - Index Medicus KW - Clinical Epidemiology KW - Lung Cancer KW - Air Pollution, Indoor -- adverse effects KW - Humans KW - Wood KW - Male KW - Female KW - Lung Neoplasms -- etiology KW - Heating KW - Cooking KW - Biomass KW - Energy-Generating Resources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673372021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thorax&rft.atitle=Does+household+use+of+biomass+fuel+cause+lung+cancer%3F+A+systematic+review+and+evaluation+of+the+evidence+for+the+GBD+2010+study.&rft.au=Bruce%2C+Nigel%3BDherani%2C+Mukesh%3BLiu%2C+Rui%3BHosgood%2C+H+Dean%3BSapkota%2C+Amir%3BSmith%2C+Kirk+R%3BStraif%2C+Kurt%3BLan%2C+Qing%3BPope%2C+Daniel&rft.aulast=Bruce&rft.aufirst=Nigel&rft.date=2015-05-01&rft.volume=70&rft.issue=5&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=1468-3296&rft_id=info:doi/10.1136%2Fthoraxjnl-2014-206625 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-22 N1 - Date created - 2015-04-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/thoraxjnl-2014-206625 ER - TY - JOUR T1 - Differential gene expression in Staphylococcus aureus exposed to Orange II and Sudan III azo dyes. AN - 1672609066; 25720844 AB - We previously demonstrated the effects of azo dyes and their reduction metabolites on bacterial cell growth and cell viability. In this report, the effects of Orange II and Sudan III on gene expression profiling in Staphylococcus aureus ATCC BAA 1556 were analyzed using microarray and quantitative RT-PCR technology. Upon exposure to 6 μg/ml Orange II for 18 h, 21 genes were found to be differently expressed. Among them, 8 and 13 genes were up- and down-regulated, respectively. Most proteins encoded by these differentially expressed genes involve stress response caused by drug metabolism, oxidation, and alkaline shock indicating that S. aureus could adapt to Orange II exposure through a balance between up and down regulated gene expression. Whereas, after exposure to 6 μg/ml Sudan III for 18 h, 57 genes were differentially expressed. In which, 51 genes were up-regulated and 6 were down-regulated. Most proteins encoded by these differentially expressed genes involve in cell wall/membrane biogenesis and biosynthesis, nutrient uptake, transport and metabolite, and stress response, suggesting that Sudan III damages the bacterial cell wall or/and membrane due to binding of the dye. Further analysis indicated that all differentially expressed genes encoded membrane proteins were up-regulated and most of them serve as transporters. The result suggested that these genes might contribute to survival, persistence and growth in the presence of Sudan III. Only one gene msrA, which plays an important role in oxidative stress resistance, was found to be down-regulated after exposure to both Orange II and Sudan III. The present results suggested that both these two azo dyes can cause stress in S. aureus and the response of the bacterium to the stress is mainly related to characteristics of the azo dyes. JF - Journal of industrial microbiology & biotechnology AU - Pan, Hongmiao AU - Xu, Joshua AU - Kweon, Oh-Gew AU - Zou, Wen AU - Feng, Jinhui AU - He, Gui-Xin AU - Cerniglia, Carl E AU - Chen, Huizhong AD - Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Rd., Jefferson, AR, 72079-9502, USA. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 745 EP - 757 VL - 42 IS - 5 KW - Azo Compounds KW - 0 KW - Benzenesulfonates KW - Coloring Agents KW - sudan III KW - ND733RX3JN KW - 2-naphthol orange KW - Q1LIY3BO0U KW - Index Medicus KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis KW - Up-Regulation -- drug effects KW - Oxidative Stress -- drug effects KW - Genes, Bacterial -- genetics KW - Oxidative Stress -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Down-Regulation -- drug effects KW - Time Factors KW - Coloring Agents -- pharmacology KW - Benzenesulfonates -- pharmacology KW - Staphylococcus aureus -- genetics KW - Gene Expression Regulation, Bacterial -- drug effects KW - Azo Compounds -- pharmacology KW - Staphylococcus aureus -- drug effects KW - Staphylococcus aureus -- metabolism KW - Staphylococcus aureus -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1672609066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+industrial+microbiology+%26+biotechnology&rft.atitle=Differential+gene+expression+in+Staphylococcus+aureus+exposed+to+Orange+II+and+Sudan+III+azo+dyes.&rft.au=Pan%2C+Hongmiao%3BXu%2C+Joshua%3BKweon%2C+Oh-Gew%3BZou%2C+Wen%3BFeng%2C+Jinhui%3BHe%2C+Gui-Xin%3BCerniglia%2C+Carl+E%3BChen%2C+Huizhong&rft.aulast=Pan&rft.aufirst=Hongmiao&rft.date=2015-05-01&rft.volume=42&rft.issue=5&rft.spage=745&rft.isbn=&rft.btitle=&rft.title=Journal+of+industrial+microbiology+%26+biotechnology&rft.issn=1476-5535&rft_id=info:doi/10.1007%2Fs10295-015-1599-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-21 N1 - Date created - 2015-04-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10295-015-1599-4 ER - TY - JOUR T1 - Rapid determination of plasmonic nanoparticle agglomeration status in blood. AN - 1664205832; 25771013 AB - Plasmonic nanomaterials as drug delivery or bio-imaging agents are typically introduced to biological systems through intravenous administration. However, the potential for agglomeration of nanoparticles in biological systems could dramatically affect their pharmacokinetic profile and toxic potential. Development of rapid screening methods to evaluate agglomeration is urgently needed to monitor the physical nature of nanoparticles as they are introduced into blood. Here, we establish novel methods using darkfield microscopy with hyperspectral detection (hsDFM), single particle inductively-coupled plasma mass spectrometry (spICP-MS), and confocal Raman microscopy (cRM) to discriminate gold nanoparticles (AuNPs) and their agglomerates in blood. Rich information about nanoparticle agglomeration in situ is provided by hsDFM monitoring of the plasmon resonance of primary nanoparticles and their agglomerates in whole blood; cRM is an effective complement to hsDFM to detect AuNP agglomerates in minimally manipulated samples. The AuNPs and the particle agglomerates were further distinguished in blood for the first time by quantification of particle mass using spICP-MS with excellent sensitivity and specificity. Furthermore, the agglomeration status of synthesized and commercial NPs incubated in blood was successfully assessed using the developed methods. Together, these complementary methods enable rapid determination of the agglomeration status of plasmonic nanomaterials in biological systems, specifically blood. Published by Elsevier Ltd. JF - Biomaterials AU - Jenkins, Samir V AU - Qu, Haiou AU - Mudalige, Thilak AU - Ingle, Taylor M AU - Wang, Rongrong AU - Wang, Feng AU - Howard, Paul C AU - Chen, Jingyi AU - Zhang, Yongbin AD - NCTR/ORA Nanotechnology Core Facility, U.S. Food and Drug Administration, Jefferson, AR 72079, United States; Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, United States. ; NCTR/ORA Nanotechnology Core Facility, U.S. Food and Drug Administration, Jefferson, AR 72079, United States; Arkansas Regional Laboratory, Office of Regulatory Affairs, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; NCTR/ORA Nanotechnology Core Facility, U.S. Food and Drug Administration, Jefferson, AR 72079, United States; Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. ; NCTR/ORA Nanotechnology Core Facility, U.S. Food and Drug Administration, Jefferson, AR 72079, United States; Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States; Hunan Province of Food and Drug Control, Changsha, Hunan 410001, China. ; Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, United States. ; NCTR/ORA Nanotechnology Core Facility, U.S. Food and Drug Administration, Jefferson, AR 72079, United States; Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: Yongbin.Zhang@fda.hhs.gov. Y1 - 2015/05// PY - 2015 DA - May 2015 SP - 226 EP - 237 VL - 51 KW - Citrates KW - 0 KW - Index Medicus KW - Blood KW - Single particle ICP-MS KW - Gold KW - Darkfield microscopy KW - Silver KW - Nanoparticles KW - Animals KW - Rats, Inbred F344 KW - Scattering, Radiation KW - Microscopy KW - Citrates -- chemistry KW - Spectrophotometry, Atomic KW - Spectrum Analysis, Raman KW - Metal Nanoparticles -- chemistry KW - Metal Nanoparticles -- ultrastructure KW - Blood -- metabolism KW - Metal Nanoparticles -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664205832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Rapid+determination+of+plasmonic+nanoparticle+agglomeration+status+in+blood.&rft.au=Jenkins%2C+Samir+V%3BQu%2C+Haiou%3BMudalige%2C+Thilak%3BIngle%2C+Taylor+M%3BWang%2C+Rongrong%3BWang%2C+Feng%3BHoward%2C+Paul+C%3BChen%2C+Jingyi%3BZhang%2C+Yongbin&rft.aulast=Jenkins&rft.aufirst=Samir&rft.date=2015-05-01&rft.volume=51&rft.issue=&rft.spage=226&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=1878-5905&rft_id=info:doi/10.1016%2Fj.biomaterials.2015.01.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-08 N1 - Date created - 2015-03-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Science. 2006 Feb 3;311(5761):622-7 [16456071] Environ Sci Technol. 2012 Sep 18;46(18):10081-8 [22906208] Nanomedicine. 2007 Mar;3(1):89-94 [17379173] Annu Rev Phys Chem. 2007;58:267-97 [17067281] Nano Lett. 2007 Jun;7(6):1542-50 [17465586] J Colloid Interface Sci. 2007 Sep 15;313(2):724-34 [17540397] Nat Biotechnol. 2008 Jan;26(1):83-90 [18157119] J Am Chem Soc. 2008 Nov 12;130(45):14934-5 [18937463] ACS Nano. 2008 Aug;2(8):1639-44 [19206367] Nanomedicine. 2009 Jun;5(2):118-27 [19480047] Nano Lett. 2009 Oct;9(10):3612-8 [19645464] ACS Nano. 2009 May 26;3(5):1190-202 [19354266] J Chromatogr A. 2009 Dec 25;1216(52):9034-47 [19631942] ACS Nano. 2010 Jan 26;4(1):365-79 [20020753] ACS Nano. 2010 Jun 22;4(6):3181-6 [20481456] J Am Chem Soc. 2010 Aug 11;132(31):10903-10 [20681724] ACS Nano. 2010 Jul 27;4(7):3623-32 [20553005] Biomaterials. 2010 Oct;31(30):7606-19 [20656344] ACS Nano. 2010 Oct 26;4(10):5527-31 [20973573] N Engl J Med. 2010 Dec 16;363(25):2434-43 [21158659] Clin Cancer Res. 2010 Dec 15;16(24):6139-49 [20876255] Mol Pharm. 2011 Feb 7;8(1):176-84 [21053973] Cancer Res. 2011 Mar 1;71(5):1526-32 [21212408] ACS Nano. 2011 Mar 22;5(3):1630-8 [21366249] Nano Lett. 2011 Apr 13;11(4):1733-8 [21410218] Anal Bioanal Chem. 2011 Oct;401(6):1993-2002 [21808990] ACS Nano. 2011 Sep 27;5(9):7020-33 [21866971] Acc Chem Res. 2011 Oct 18;44(10):914-24 [21528889] Int J Nanomedicine. 2012;7:5625-39 [23144562] Anal Chem. 2013 Feb 5;85(3):1290-4 [23320416] Phys Chem Chem Phys. 2013 Mar 28;15(12):4163-8 [23183927] Nat Commun. 2013;4:1673 [23575677] Small. 2013 May 27;9(9-10):1715-20 [23335405] Acc Chem Res. 2013 Mar 19;46(3):743-9 [22786674] Nat Nanotechnol. 2014 Jun;9(6):481-7 [24727688] Nat Nanotechnol. 2014 Jun;9(6):474-80 [24747838] Acc Chem Res. 2011 Oct 18;44(10):936-46 [21612199] Nanomedicine (Lond). 2012 Feb;7(2):199-209 [22339133] Chem Soc Rev. 2012 Apr 7;41(7):2740-79 [22109657] Chem Soc Rev. 2012 Apr 7;41(7):2849-66 [22182959] Chem Soc Rev. 2012 Apr 7;41(7):2943-70 [22388295] Science. 2012 Apr 20;336(6079):299-300 [22517845] Langmuir. 2012 Jun 19;28(24):9131-9 [22515552] Ther Deliv. 2012 Apr;3(4):457-78 [22834077] ACS Nano. 2012 Aug 28;6(8):7122-32 [22799499] Environ Sci Technol. 2006 Jul 15;40(14):4353-9 [16903270] J Sep Sci. 2013 Sep;36(17):2952-61 [23857600] Nano Lett. 2014 Jan 8;14(1):83-8 [24313755] Nano Lett. 2014 Jan 8;14(1):373-8 [24325680] Chem Rev. 2014 Jan 22;114(2):1258-88 [24279480] J Food Drug Anal. 2014 Mar;22(1):147-60 [24673911] Anal Chem. 2014 Apr 1;86(7):3405-14 [24575780] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.biomaterials.2015.01.072 ER - TY - JOUR T1 - 7-glutathione pyrrole adduct: a potential DNA reactive metabolite of pyrrolizidine alkaloids. AN - 1674689702; 25768656 AB - Pyrrolizidine alkaloid (PA)-containing plants are the most common poisonous plants affecting livestock, wildlife, and humans. PAs require metabolic activation to form pyrrolic metabolites to exert cytotoxicity and tumorigenicity. We previously determined that metabolism of tumorigenic PAs produced four DNA adducts, designated as DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4, that are responsible for liver tumor initiation. 7-Glutathione-(±)-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine (7-GS-DHP), formed in vivo and in vitro, and 7,9-di-GS-DHP, formed in vitro, are both considered detoxified metabolites. However, in this study we determined that incubation of 7-GS-DHP with 2'-deoxyguanosine (dG) and 2'-deoxyadenosine (dA) yields DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts as well as the reactive metabolite DHP. Furthermore, reaction of 7-GS-DHP with calf thymus DNA in aqueous solution at 37 °C for 4, 8, 16, 24, 48, or 72 h, followed by enzymatic hydrolysis yielded DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4 adducts. Under our current experimental conditions, DHP-dA-3 and DHP-dA-4 adducts were formed in a trace amount from the reaction of 7,9-di-GS-DHP with dA. No DHP-dG-3 or DHP-dG-4 adducts were detected from the reaction of 7,9-di-GS-DHP with dG. This study represents the first report that the 7-GS-DHP adduct can be a potential reactive metabolite of PAs leading to DNA adduct formation. JF - Chemical research in toxicology AU - Xia, Qingsu AU - Ma, Liang AU - He, Xiaobo AU - Cai, Lining AU - Fu, Peter P AD - †National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079, United States. ; ‡Biotranex LLC, Monmouth Junction, New Jersey 08852, United States. Y1 - 2015/04/20/ PY - 2015 DA - 2015 Apr 20 SP - 615 EP - 620 VL - 28 IS - 4 KW - DNA Adducts KW - 0 KW - Pyrroles KW - Pyrrolizidine Alkaloids KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Animals KW - Cattle KW - Chromatography, High Pressure Liquid KW - DNA Adducts -- chemistry KW - Glutathione -- chemistry KW - Pyrroles -- chemistry KW - Pyrrolizidine Alkaloids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1674689702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=7-glutathione+pyrrole+adduct%3A+a+potential+DNA+reactive+metabolite+of+pyrrolizidine+alkaloids.&rft.au=Xia%2C+Qingsu%3BMa%2C+Liang%3BHe%2C+Xiaobo%3BCai%2C+Lining%3BFu%2C+Peter+P&rft.aulast=Xia&rft.aufirst=Qingsu&rft.date=2015-04-20&rft.volume=28&rft.issue=4&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx500417q LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-04-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/tx500417q ER - TY - CPAPER T1 - Human biospecimens for in vitro diagnostics: Regulatory considerations T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669824171; 6339255 JF - 2015 American Association for Cancer Research Annual Meeting AU - Hu, Yun-Fu Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Epidemiology KW - Oncology KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669824171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Human+biospecimens+for+in+vitro+diagnostics%3A+Regulatory+considerations&rft.au=Hu%2C+Yun-Fu&rft.aulast=Hu&rft.aufirst=Yun-Fu&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Next Generation Sequencing Tests - Optimizing Regulatory Oversight, from Cancer Panels to Whole Genome T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669823826; 6339646 JF - 2015 American Association for Cancer Research Annual Meeting AU - Tezak, Zivana Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Genomes KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Next+Generation+Sequencing+Tests+-+Optimizing+Regulatory+Oversight%2C+from+Cancer+Panels+to+Whole+Genome&rft.au=Tezak%2C+Zivana&rft.aulast=Tezak&rft.aufirst=Zivana&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Mechanism of the transferrin receptor 1 dysregulation in hepatocarcinogenesis T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669823618; 6339530 JF - 2015 American Association for Cancer Research Annual Meeting AU - Kindrat, Iryna Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Transferrin receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Mechanism+of+the+transferrin+receptor+1+dysregulation+in+hepatocarcinogenesis&rft.au=Kindrat%2C+Iryna&rft.aulast=Kindrat&rft.aufirst=Iryna&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Careers in Government T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669823561; 6339399 JF - 2015 American Association for Cancer Research Annual Meeting AU - Lyn-Cook, Beverly Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Careers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Careers+in+Government&rft.au=Lyn-Cook%2C+Beverly&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Careers in Cancer: Government T2 - 2015 American Association for Cancer Research Annual Meeting AN - 1669823150; 6340078 JF - 2015 American Association for Cancer Research Annual Meeting AU - Lyn-Cook, Beverly Y1 - 2015/04/18/ PY - 2015 DA - 2015 Apr 18 KW - Careers KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669823150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.atitle=Careers+in+Cancer%3A+Government&rft.au=Lyn-Cook%2C+Beverly&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2015-04-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Association+for+Cancer+Research+Annual+Meeting&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={19573A54-AE8F-4E00-9C23-BD6D62268424} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Tuberculosis Control in South African Gold Mines: Mathematical Modeling of a Trial of Community-Wide Isoniazid Preventive Therapy AN - 1709174263; PQ0001732834 AB - A recent major cluster randomized trial of screening, active disease treatment, and mass isoniazid preventive therapy for 9 months during 2006-2011 among South African gold miners showed reduced individual-level tuberculosis incidence but no detectable population-level impact. We fitted a dynamic mathematical model to trial data and explored 1) factors contributing to the lack of population-level impact, 2) the best-achievable impact if all implementation characteristics were increased to the highest level achieved during the trial ("optimized intervention"), and 3) how tuberculosis might be better controlled with additional interventions (improving diagnostics, reducing treatment delay, providing isoniazid preventive therapy continuously to human immunodeficiency virus-positive people, or scaling up antiretroviral treatment coverage) individually and in combination. We found the following: 1) The model suggests that a small proportion of latent infections among human immunodeficiency virus-positive people were cured, which could have been a key factor explaining the lack of detectable population-level impact. 2) The optimized implementation increased impact by only 10%. 3) Implementing additional interventions individually and in combination led to up to 30% and 75% reductions, respectively, in tuberculosis incidence after 10 years. Tuberculosis control requires a combination prevention approach, including health systems strengthening to minimize treatment delay, improving diagnostics, increased antiretroviral treatment coverage, and effective preventive treatment regimens. JF - American Journal of Epidemiology AU - Vynnycky, Emilia AU - Sumner, Tom AU - Fielding, Katherine L AU - Lewis, James J AU - Cox, Andrew P AU - Hayes, Richard J AU - Corbett, Elizabeth L AU - Churchyard, Gavin J AU - Grant, Alison D AU - White, Richard G AD - Correspondence to Dr. Emilia Vynnycky, Statistics, Modelling and Economics Department, Public Health England, 61 Colindale Avenue, London NW9 5EQ, United Kingdom,; emilia.vynnycky@lshtm.ac.uk] emilia.vynnycky@phe.gov.uk Y1 - 2015/04/15/ PY - 2015 DA - 2015 Apr 15 SP - 619 EP - 632 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 181 IS - 8 SN - 0002-9262, 0002-9262 KW - Microbiology Abstracts B: Bacteriology KW - mass community-wide isoniazid preventive therapy KW - mathematical model KW - tuberculosis KW - Latent infection KW - Mathematical models KW - Data processing KW - Antiviral agents KW - Mycobacterium KW - Immunodeficiency KW - Gold KW - Tuberculosis KW - Mines KW - Scaling KW - Isoniazid KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709174263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Tuberculosis+Control+in+South+African+Gold+Mines%3A+Mathematical+Modeling+of+a+Trial+of+Community-Wide+Isoniazid+Preventive+Therapy&rft.au=Vynnycky%2C+Emilia%3BSumner%2C+Tom%3BFielding%2C+Katherine+L%3BLewis%2C+James+J%3BCox%2C+Andrew+P%3BHayes%2C+Richard+J%3BCorbett%2C+Elizabeth+L%3BChurchyard%2C+Gavin+J%3BGrant%2C+Alison+D%3BWhite%2C+Richard+G&rft.aulast=Vynnycky&rft.aufirst=Emilia&rft.date=2015-04-15&rft.volume=181&rft.issue=8&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/10.1093%2Faje%2Fkwu320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Latent infection; Data processing; Mathematical models; Antiviral agents; Immunodeficiency; Gold; Tuberculosis; Mines; Scaling; Isoniazid; Mycobacterium DO - http://dx.doi.org/10.1093/aje/kwu320 ER - TY - JOUR T1 - Non-fatal work-related traumatic brain injuries treated in US hospital emergency departments, 1998-2007 AN - 1808706884; PQ0003427539 AB - PurposeLittle is known about work-related traumatic brain injuries (WRTBI). This study describes non-fatal WRTBIs treated in US emergency departments (ED) from 1998 through 2007.MethodsNon-fatal WRTBIs were identified from the National Electronic Injury Surveillance System occupational supplement (NEISS-Work) using the diagnoses of concussion, internal organ injury to the head and skull fracture. WRTBI rates and rate ratios were calculated, and the trend in rates was assessed.ResultsAn estimated 586600 (95% CI= plus or minus 150000) WRTBIs were reported during the 10-year period at a rate of 4.3 (CI= plus or minus 1.1) per 10000 full-time equivalent (FTE) workers (1 FTE=2000h per year). From 1998 through 2007, the rate of WRTBIs increased at an average of 0.21 per 10000 FTE per year (p<0.0001) and the rate of fall-related WRTBIs increased at an average of 0.10 per 10000 FTE (p<0.0001). During the same period, the annual rate of WRTBIs resulting in hospitalisation increased 0.04 per 10000 FTE (p<0.0001). Ten percent of WRTBIs were hospitalised, compared with hospitalisation of 2% all NEISS-Work injuries. Also, workers with highest fall-related TBI rates per 10000 FTE were the youngest (2.4; CI= plus or minus 1.4) and oldest (55 and older) workers (1.9; CI= plus or minus 0.8).ConclusionsNon-fatal WRTBIs are one of the most serious workplace injuries among ED-treated work-related injuries. Non-fatal WRTBIs are much more likely to result in hospitalisation compared with other types of injuries. The upward trend of WRTBI rates from 1998 through 2007 underscore the need for more directed effective prevention methods to reduce WRTBI injuries. JF - Injury Prevention AU - Konda, Srinivas AU - Reichard, Audrey AU - Tiesman, Hope M AU - Hendricks, Scott AD - Division of Safety Research, Analysis and Field Evaluations Branch, National Institute for Occupational Safety and Health, , Morgantown, West Virginia, USA Y1 - 2015/04/12/ PY - 2015 DA - 2015 Apr 12 SP - 115 EP - 120 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 21 IS - 2 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - Prevention KW - Injuries KW - Head injuries KW - Brain KW - Organs KW - Emergency medical services KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808706884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=Non-fatal+work-related+traumatic+brain+injuries+treated+in+US+hospital+emergency+departments%2C+1998-2007&rft.au=Konda%2C+Srinivas%3BReichard%2C+Audrey%3BTiesman%2C+Hope+M%3BHendricks%2C+Scott&rft.aulast=Konda&rft.aufirst=Srinivas&rft.date=2015-04-12&rft.volume=21&rft.issue=2&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/10.1136%2Finjuryprev-2014-041323 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Prevention; Injuries; Head injuries; Brain; Organs; Hospitals; Emergency medical services DO - http://dx.doi.org/10.1136/injuryprev-2014-041323 ER - TY - RPRT T1 - NATIONAL INSTITUTES OF HEALTH BETHESDA CHILLED WATER SYSTEM IMPROVEMENTS, MONTGOMERY COUNTY, BETHESEDA, MARYLAND. AN - 16377952; 16466 AB - PURPOSE: The National Institutes of Health (NIH) is contemplating implementation of chilled water system improvements at the NIH Bethesda Campus. The need for the chilled water system improvements is to prevent a disruption in the chilled water supply which would result in severe consequences on patient care, animal welfare, and biomedical research. Improvements are needed to address real deficiencies within the campus water systems. Three alternatives were considered in detail in the Draft Environmental Impact Statement. The Proposed Action would install a Thermal Energy Storage System and an Industrial Water Storage System to provide sufficient storage capacity to meet two days of chilled water demand and two days of industrial water demand should an outside disturbance interrupt the water supply. The Alternative Action would install a Thermal Energy Storage System and a Potable Water Storage System to provide sufficient storage capacity to meet two days of chilled water demand and two days of potable water demand. The No-Action Alternative would continue current NIH operations and would not implement chilled water system improvements. JF - EPA number: 150089, Draft EIS, April 3, 2015 Y1 - 2015/04/03/ PY - 2015 DA - 2015 Apr 03 KW - Water KW - Water Storage KW - Water Supply KW - Industrial Water KW - Water Resources KW - Wetlands KW - Floodplains KW - Traffic Analyses KW - Noise KW - Air Quality KW - Vegetation KW - Wildlife Habitat KW - Soils KW - Archaeological Sites KW - Socioeconomic Assessments KW - Emissions KW - Historic Sites KW - Waste Management KW - Maryland KW - Clean Air Act Amendments of 1990, Emission Standards KW - Resources Conservation and Recovery Act, Compliance KW - National Historic Preservation Act of 1966, Historic Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16377952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2015-04-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CHILLED+WATER+SYSTEM+IMPROVEMENTS%2C+MONTGOMERY+COUNTY%2C+BETHESEDA%2C+MARYLAND.&rft.title=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CHILLED+WATER+SYSTEM+IMPROVEMENTS%2C+MONTGOMERY+COUNTY%2C+BETHESEDA%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland N1 - Date revised - 2016-07-07 N1 - SuppNotes - Draft. Preparation date: April 3, 2015 N1 - Last updated - 2016-07-08 ER - TY - JOUR T1 - Binge drinking and the risk of suicidal thoughts, plans, and attempts AN - 1837328674; PQ0001250489 AB - Background: Major depression is one of the strongest known risk factors for suicide. However, of the estimated 8.5 million adults with serious thoughts of suicide in the past year, only half had a major depressive episode (MDE). identifying risk factors for suicide in the absence of depression may provide additional targets for prevention and intervention. This study uses nationally representative data to evaluate the association of binge drinking with suicidal thoughts, plans, and attempts in adults with and without MDE. Methods: Combined 2008-2012 National Survey on Drug Use and Health data were analyzed. Sex-stratified prevalence estimates of past year suicide indicators were generated by past month binge drinking and past year MDE status. Logistic regression was used to evaluate the association of binge drinking with suicide indicators by sex with and without MDE. Results: Unadjusted prevalence estimates for suicide indicators in males and females were higher among binge drinkers than among nonbinge drinkers, regardless of MDE status. Regression analyses indicated that binge drinking was associated with suicidal thoughts (adjusted odds ratio [aOR] = 1.51, 95% confidence interval [CI] = 1.28-1.79), plans (aOR = 1.75, CI = 1.23-2.48), and attempts (aOR = 2.57, CI = 1.74-3.79) in females without MDE and with suicidal thoughts in males without MDE (aOR = 1.25, CI = 1.04-1.49). Among males and females with MDE, binge drinking was not associated with any of the suicide indicators (p > .05). Conclusions: Binge drinking in females without MDE may be an indicator for identifying at risk individuals for targeting suicide prevention activities. JF - Addictive Behaviors AU - Glasheen, Cristie AU - Pemberton, Michael R AU - Lipari, Rachel AU - Copello, Elizabeth A AU - Mattson, Margaret E AD - RTI International (a trade name of Research Triangle Institute International), 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC27709, United States, Margaret.Mattson@samhsa.hhs.gov Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 42 EP - 49 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 43 SN - 0306-4603, 0306-4603 KW - Toxicology Abstracts KW - Alcohol drinking KW - Binge drinking KW - Suicide KW - Sex KW - Depression KW - Drinking KW - Data processing KW - Risk factors KW - Regression analysis KW - Drugs KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837328674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Binge+drinking+and+the+risk+of+suicidal+thoughts%2C+plans%2C+and+attempts&rft.au=Glasheen%2C+Cristie%3BPemberton%2C+Michael+R%3BLipari%2C+Rachel%3BCopello%2C+Elizabeth+A%3BMattson%2C+Margaret+E&rft.aulast=Glasheen&rft.aufirst=Cristie&rft.date=2015-04-01&rft.volume=43&rft.issue=&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2014.12.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Drinking; Depression; Data processing; Risk factors; Regression analysis; Suicide; Drugs; Sex DO - http://dx.doi.org/10.1016/j.addbeh.2014.12.005 ER - TY - JOUR T1 - 0058Associations between socioeconomic status, rurality and motor vehicle traffic crash injury severity and treatment outcomes: findings from the nebraska trauma registry AN - 1808716028; PQ0003431131 AB - Statement of purposeBased on geocoded data from the Nebraska's trauma registry, the current study examines how socioeconomic status and rurality are associated with MVC injury severity and treatment outcomes.Methods/ApproachData from 2007-2012 was taken from Nebraska's Trauma Registry. Injuries caused by MVC were identified using ICD-9 External Cause of Injury Codes. 13,693 cases in the registry met criteria for this study.Cases were geocoded to residential addresses. Poverty status was determined by census tract, and rurality by county. Descriptive and multivariate analyses were used to determine associations between outcome variables, and socioeconomic status (neighbourhood poverty levels) and rurality. Two outcome variables, hospital length of stay and discharge to rehabilitative or homecare services, were considered.ResultsPersons from low-income neighbourhoods had a greater rate of inpatient treatment than persons from wealthier neighbourhoods. In particular, single-system or minor injuries (ISS <15) from lower income neighbourhoods were comparatively more likely to be admitted. Persons under 65 years old from low-income neighbourhoods had a significantly longer mean length of stay in the hospital for minor injuries. Persons from rural areas were less likely to be discharged to further services, and moderately more likely to have longer lengths of stay.ConclusionsPersons from low-income neighbourhoods were more likely to be admitted for minor injuries, to remain longer in the hospital and to be discharged without further services. This suggests that this group may lack access to outpatient care to treat minor injuries, or to continue treatment once discharged. The latter may encourage longer stays in hospital to ensure treatment compliance. Lack of access was also apparent for rural patients, who had longer lengths of stay and fewer discharges to further services than their urban counterparts.Significance and contribution to the fieldPrevious studies examining individual and neighbourhood risk factors of Motor Vehicle Traffic Crashes (MVC) injuries often use data sources where treatment and treatment outcomes were not often considered or reliable. Trauma Registry data provides rich and reliable patient information. JF - Injury Prevention AU - Cooper, Rachel AU - Qu, Ming AU - Lin, Ge AD - Nebraska Department of Health and Human Services, Lincoln, NE, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - A15 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 21 IS - Suppl 1 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - Injuries KW - Motor vehicles KW - Compliance KW - Socioeconomics KW - Traffic KW - Income KW - Prevention KW - Poverty KW - Risk factors KW - USA, Nebraska KW - Census KW - Rural areas KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808716028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=0058Associations+between+socioeconomic+status%2C+rurality+and+motor+vehicle+traffic+crash+injury+severity+and+treatment+outcomes%3A+findings+from+the+nebraska+trauma+registry&rft.au=Cooper%2C+Rachel%3BQu%2C+Ming%3BLin%2C+Ge&rft.aulast=Cooper&rft.aufirst=Rachel&rft.date=2015-04-01&rft.volume=21&rft.issue=Suppl+1&rft.spage=A15&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/10.1136%2Finjuryprev-2015-041602.37 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Prevention; Injuries; Risk factors; Poverty; Motor vehicles; Compliance; Socioeconomics; Census; Income; Rural areas; Traffic; USA, Nebraska DO - http://dx.doi.org/10.1136/injuryprev-2015-041602.37 ER - TY - JOUR T1 - 50Assessing the impact of niosh occupational motor vehicle safety research AN - 1808647116; PQ0003435172 AB - The ultimate purpose of violence and injury research is to make positive impacts on the public's safety. Documenting these impacts is challenging, especially since research is just one of many inputs that influence policy, the environment, and behaviour. Nonetheless, research agencies and researchers are increasingly being called upon to demonstrate the impact of their work, going beyond traditional metrics such as numbers of journal article citations. The Centres for Disease Control and Prevention (CDC) recently developed a framework for documenting science impacts, adapted from the Institute of Medicine Degrees of Impact framework. The CDC Science Impact Framework uses a combination of narrative, quantitative, and qualitative Methods to document and trace linkages between science and the events and actions that ultimately lead to public health impacts. Starting with a significant output (such as a seminal paper or technological innovation), the framework is used either prospectively or retrospectively to document and demonstrate linkages across five levels of influence: disseminating science, creating awareness, catalysing action, effecting change, and shaping the future. This presentation will illustrate how the CDC Science Impact Framework was applied to the CDC's National Institute for Occupational Safety and Health (NIOSH) research program on occupational motor vehicle safety. Motor vehicles are a leading cause of death and injury at work, and the occupational setting provides unique opportunities for intervention, including influencing employer policies and practices, guidance and materials used by unions and occupational safety professionals, and the design and use of engineering controls on unique work vehicles (e.g. tractor-trailers, fire trucks, and ambulances). This presentation will provide examples of how impacts were traced from key NIOSH documents containing evidence-based policy recommendations and other NIOSH research findings. It will also include lessons learned from this exercise in terms of maximising future impact.DisclaimerThe findings and conclusions in this abstract are those of the authors and do not necessarily represent the views of NIOSH. JF - Injury Prevention AU - Castillo, Dawn AU - Novicki, Emily AU - Pratt, Stephanie AD - National Institute for Occupational Safety and Health, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - A18 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 21 IS - Suppl 2 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - Mortality KW - Fires KW - Injuries KW - Motor vehicles KW - Occupational safety KW - Safety KW - Disease control KW - Intervention KW - Public health KW - Prevention KW - Safety engineering KW - Trucks KW - Research programs KW - Agricultural equipment KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808647116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=50Assessing+the+impact+of+niosh+occupational+motor+vehicle+safety+research&rft.au=Castillo%2C+Dawn%3BNovicki%2C+Emily%3BPratt%2C+Stephanie&rft.aulast=Castillo&rft.aufirst=Dawn&rft.date=2015-04-01&rft.volume=21&rft.issue=Suppl+2&rft.spage=A18&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/10.1136%2Finjuryprev-2015-041654.50 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Fires; Mortality; Injuries; Motor vehicles; Safety; Occupational safety; Disease control; Intervention; Public health; Prevention; Safety engineering; Trucks; Research programs; Agricultural equipment DO - http://dx.doi.org/10.1136/injuryprev-2015-041654.50 ER - TY - JOUR T1 - 0023Using the new title v MCH national performance measure 7 to reduce injury-related hospitalizations among children and adolescents ages 0-19 AN - 1808623420; PQ0003431138 AB - Statement of purposeEvery year, one in nine young people is injured seriously enough to require medical attention, and nearly 320,000 injury-related hospitalizations occur. Injuries are a leading cause of medical spending for children and adolescents, a burden estimated at $4 billion in annual healthcare costs for hospitalizations alone. By focusing on the reduction of injury-related hospitalizations, public health professionals can significantly reduce the toll of injuries in the U.S.Methods/ApproachThe Health Resources and Services Administration's Maternal and Child Health Bureau has proposed the reduction of injury-related hospitalizations among infants, children, and adolescents ages 0 through 19 as one of 15 possible National Performance Measures (NPMs) for inclusion in the Title V Maternal and Child Health Services Block Grant Program. This presentation will describe this new NPM and explain the opportunity that it provides for improving the health and safety of infants, children, and adolescents.ResultsPresenters will explain the burden of injury-related hospitalizations in the U.S.; describe the new Title V Maternal and Child Health (MCH) Performance Measure framework and how it is related to the 5-year Needs Assessments that state MCH programs are currently conducting; provide an overview of ways to get involved in the Needs Assessment process and the selection of injury-related NPMs; and share Children's Safety Network (CSN) resources on effective strategies for reducing injury-related hospitalizations.ConclusionsParticipants will be equipped to use the new injury hospitalisation NPM to address a range of important injury issues, including falls, motor vehicle crashes, prescription drug overdoses, suicide, homicide, drowning, and sudden and unexpected infant death. They will also have an opportunity for interactive discussion about ways for state injury prevention programs to collaborate with state MCH programs on the selection of evidence-based strategies to address the injury hospitalisation NPM.Significance and contribution to the fieldThe new Title V MCH Performance Measure framework provides injury prevention professionals with new opportunities to leverage existing partnerships and build new alliances to advance effective policies and practices for reducing injury-related hospitalizations. This presentation will enable participants to capitalise on those opportunities and make injury prevention a state and national priority. JF - Injury Prevention AU - Reiney, Erin AU - Allison, Jennifer AU - Hunt, Rebekah AD - Maternal and Child Health Bureau, Rockville, MD, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - A25 EP - A26 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 21 IS - Suppl 1 SN - 1353-8047, 1353-8047 KW - Health & Safety Science Abstracts KW - Mortality KW - Age KW - Drowning KW - Injuries KW - Safety KW - Suicide KW - Children KW - Prevention KW - Homicide KW - Health care KW - Priorities KW - Drugs KW - Adolescents KW - Infants KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808623420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Injury+Prevention&rft.atitle=0023Using+the+new+title+v+MCH+national+performance+measure+7+to+reduce+injury-related+hospitalizations+among+children+and+adolescents+ages+0-19&rft.au=Reiney%2C+Erin%3BAllison%2C+Jennifer%3BHunt%2C+Rebekah&rft.aulast=Reiney&rft.aufirst=Erin&rft.date=2015-04-01&rft.volume=21&rft.issue=Suppl+1&rft.spage=A25&rft.isbn=&rft.btitle=&rft.title=Injury+Prevention&rft.issn=13538047&rft_id=info:doi/10.1136%2Finjuryprev-2015-041602.63 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Injuries; Drowning; Safety; Suicide; Children; Homicide; Prevention; Health care; Priorities; Drugs; Adolescents; Infants DO - http://dx.doi.org/10.1136/injuryprev-2015-041602.63 ER - TY - JOUR T1 - The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB AN - 1785235814; PQ0002900869 AB - In the event of a mass casualty radiation incident, the gamma-H2AX foci assay could be a useful tool to estimate radiation doses received by individuals. The rapid processing time of blood samples of just a few hours and the potential for batch processing, enabling high throughput, make the assay ideal for early triage categorisation to separate the 'worried well' from the low and critically exposed by quantifying radiation-induced foci in peripheral blood lymphocytes. Within the RENEB framework, 8 European laboratories have taken part in the first European gamma-H2AX biodosimetry exercise, which consisted of a telescoring comparison of 200 circulated foci images taken from 8 samples, and a comparison of 10 fresh blood lymphocyte samples that were shipped overnight to participating labs 4 or 24 h post-exposure. Despite large variations between laboratories in the dose-response relationship for foci induction, the obtained results indicate that the network should be able to use the gamma-H2AX assay for rapidly identifying the most severely exposed individuals within a cohort who could then be prioritised for accurate chromosome dosimetry. JF - Radiation Protection Dosimetry AU - Barnard, S AU - Ainsbury, E A AU - Al-hafidh, J AU - Hadjidekova, V AU - Hristova, R AU - Lindholm, C AU - Gil, O Monteiro AU - Moquet, J AU - Moreno, M AU - Rossler, U AU - Thierens, H AU - Vandevoorde, C AU - Vral, A AU - Wojewodzka, M AU - Rothkamm, K AD - Public Health England, Centre for Radiation Chemical and Environmental Hazards, Chilton, UK, stephen.barnard@phe.gov.uk Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 265 EP - 270 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 164 IS - 3 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Chromosomes KW - Radiation KW - Dose-response effects KW - Dosimetry KW - Lymphocytes KW - ENA 18:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785235814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=The+first+gamma-H2AX+biodosimetry+intercomparison+exercise+of+the+developing+European+biodosimetry+network+RENEB&rft.au=Barnard%2C+S%3BAinsbury%2C+E+A%3BAl-hafidh%2C+J%3BHadjidekova%2C+V%3BHristova%2C+R%3BLindholm%2C+C%3BGil%2C+O+Monteiro%3BMoquet%2C+J%3BMoreno%2C+M%3BRossler%2C+U%3BThierens%2C+H%3BVandevoorde%2C+C%3BVral%2C+A%3BWojewodzka%2C+M%3BRothkamm%2C+K&rft.aulast=Barnard&rft.aufirst=S&rft.date=2015-04-01&rft.volume=164&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncu259 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-05-01 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - Chromosomes; Radiation; Dose-response effects; Dosimetry; Lymphocytes DO - http://dx.doi.org/10.1093/rpd/ncu259 ER - TY - JOUR T1 - Development of a retrospective/fortuitous accident dosimetry service based on OSL of mobile phones AN - 1785224709; PQ0002900853 AB - Work is presented on the development of a retrospective/fortuitous accident dosimetry service using optically stimulated luminescence of resistors found in mobile phones to determine the doses of radiation to members of the public following a radiological accident or terrorist incident. The system is described and discussed in terms of its likely accuracy in a real incident. JF - Radiation Protection Dosimetry AU - Smith, R W AU - Eakins, J S AU - Hager, L G AU - Rothkamm, K AU - Tanner, R J AD - Public Health England (PHE), Centre for Radiation, Chemical and Environmental Hazards (CRCE), Chilton, Didcot, Oxon OX11 0RQ, UK, rick.tanner@phe.gov.uk Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 89 EP - 92 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 164 IS - 1-2 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Accidents KW - Terrorism KW - Radiation KW - Dosimetry KW - Occupational safety KW - Cellular telephones KW - Luminescence KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1785224709?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Development+of+a+retrospective%2Ffortuitous+accident+dosimetry+service+based+on+OSL+of+mobile+phones&rft.au=Smith%2C+R+W%3BEakins%2C+J+S%3BHager%2C+L+G%3BRothkamm%2C+K%3BTanner%2C+R+J&rft.aulast=Smith&rft.aufirst=R&rft.date=2015-04-01&rft.volume=164&rft.issue=1-2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncu370 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-04-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Accidents; Terrorism; Radiation; Occupational safety; Dosimetry; Cellular telephones; Luminescence DO - http://dx.doi.org/10.1093/rpd/ncu370 ER - TY - JOUR T1 - A single chimpanzee-human neutralizing monoclonal antibody provides post-exposure protection against type 1 and type 2 polioviruses AN - 1732815754; PQ0002215087 AB - Background Development of anti-poliovirus therapies to complement vaccination is an urgent priority. A number of antiviral drugs are in development. Recently we have developed human monoclonal antibodies that could be used for treatment of chronically infected individuals and emergency response to potential reappearance of polioviruses after eradication. Objective The aim of this study was to characterize neutralizing activity of anti-poliovirus monoclonal antibody A12 against wild type, vaccine-derived, and drug-resistant poliovirus strains, evaluate in vivo pre- and post-exposure protective properties of the antibody against polioviruses of serotypes 1 and 2, and to determine whether it interferes with response to immunization with poliovirus vaccine. Study design Immunogenicity studies were performed in CD1 mice. Poliovirus neutralizing titers were determined in poliovirus microneutralization assay. Poliovirus immunization-challenge experiments were performed in poliovirus-susceptible TgPVR21 mice. Results We show that monoclonal antibody A12 effectively neutralizes in vitro a broad range of type 1 and type 2 wild and vaccine-derived polioviruses, provides effective pre- and post-exposure protection of TgPVR21 mice from challenge with a lethal dose of poliovirus. Treatment of animals with the antibody concurrent with IPV immunization does not prevent immune response to the vaccine. Conclusions Anti-poliovirus antibody A12 effectively neutralizes a range of wild and VDPV strains and protectstransgenic mice susceptible to poliovirus against lethal challenge upon pre- and post-exposure administration. This suggests that the antibodies could be used in combination with drugs and/or vaccine to improve their efficacy and prevent emergence of resistant variants, and provides a justification for initiating their clinical evaluation. JF - Journal of Clinical Virology AU - Kouiavskaia, Diana AU - Chen, Zhaochun AU - Dragunsky, Eugenia AU - Mirochnitchenko, Olga AU - Purcell, Robert AU - Chumakov, Konstantin AD - Center for Biologics Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Building 52, Room 1126, Silver Spring, MD 20993-0002, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 32 EP - 37 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 65 SN - 1386-6532, 1386-6532 KW - Toxicology Abstracts; Virology & AIDS Abstracts KW - Polio eradication KW - Antiviral therapy KW - Drug-resistance KW - Chronic virus excretors KW - Emergency prophylaxis KW - Poliovirus KW - Serotypes KW - Monoclonal antibodies KW - Drug resistance KW - Drug development KW - Immunosuppressive agents KW - Vaccination KW - Antiviral agents KW - Immunogenicity KW - Vaccines KW - Immune response KW - Lethal dose KW - X 24310:Pharmaceuticals KW - V 22350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732815754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Virology&rft.atitle=A+single+chimpanzee-human+neutralizing+monoclonal+antibody+provides+post-exposure+protection+against+type+1+and+type+2+polioviruses&rft.au=Kouiavskaia%2C+Diana%3BChen%2C+Zhaochun%3BDragunsky%2C+Eugenia%3BMirochnitchenko%2C+Olga%3BPurcell%2C+Robert%3BChumakov%2C+Konstantin&rft.aulast=Kouiavskaia&rft.aufirst=Diana&rft.date=2015-04-01&rft.volume=65&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Virology&rft.issn=13866532&rft_id=info:doi/10.1016%2Fj.jcv.2015.01.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Serotypes; Antiviral agents; Immunogenicity; Monoclonal antibodies; Drug resistance; Drug development; Immune response; Vaccines; Vaccination; Immunosuppressive agents; Lethal dose; Poliovirus DO - http://dx.doi.org/10.1016/j.jcv.2015.01.023 ER - TY - JOUR T1 - Validation of an HPLC-MS/MS and Wipe Procedure for Mitomycin C Contamination AN - 1717497239; PQ0001720333 AB - A high-performance liquid chromatography-tandem mass spectrometric (HPLC-MS/MS) method was developed for the determination of mitomycin C, an anticancer drug, from contamination on various surfaces. Mitomycin C is often used in various forms of intraperitoneal chemotherapy, and operating room healthcare worker exposure to this drug is possible. The surface testing method consisted of a wiping procedure utilizing a solution of 20/45/35 (v/v/v) of acetonitrile-isopropanol-water made 0.01 M in ammonium citrate (apparent pH 7.0). The wipe solutions were analyzed by means of HPLC-MS/MS using a reversed-phase gradient system and electrospray ionization in positive ion mode with a triple-quadrupole MS detector. Accuracy and precision of this method were demonstrated by a series of recovery studies of both spiked solutions and extracted wipes from various surfaces (stainless steel, vinyl and Formica(R)) spiked with known levels of mitomycin C. Recoveries of spiked solutions containing the analyte demonstrate mean recoveries (accuracy) ranged from 93 to 105%. Precision as measured by the relative standard deviation (% RSD) of multiple samples (n= 10) at each concentration level demonstrated values of 7.5% or less. The recoveries from spiked surfaces varied from 30 to 99%. The limit of detection for this methodology is ~2 ng/100 cm super(2) equivalent surface area, and the limit of quantitation is ~6 ng/100 cm super(2). JF - Journal of Chromatographic Science AU - B'Hymer, Clayton AU - Connor, Thomas AU - Stinson, Derek AU - Pretty, Jack AD - U.S. Department of Health and Human Services, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Taft Laboratory C-23, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, cbhymer@cdc.gov Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 619 EP - 624 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 53 IS - 4 SN - 0021-9665, 0021-9665 KW - Health & Safety Science Abstracts KW - Ammonium KW - Contamination KW - Chemotherapy KW - Surface area KW - Steel KW - Drugs KW - Medical personnel KW - pH KW - H 0500:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717497239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatographic+Science&rft.atitle=Validation+of+an+HPLC-MS%2FMS+and+Wipe+Procedure+for+Mitomycin+C+Contamination&rft.au=B%27Hymer%2C+Clayton%3BConnor%2C+Thomas%3BStinson%2C+Derek%3BPretty%2C+Jack&rft.aulast=B%27Hymer&rft.aufirst=Clayton&rft.date=2015-04-01&rft.volume=53&rft.issue=4&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatographic+Science&rft.issn=00219665&rft_id=info:doi/10.1093%2Fchromsci%2Fbmu095 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Ammonium; Contamination; Surface area; Chemotherapy; Steel; Drugs; pH; Medical personnel DO - http://dx.doi.org/10.1093/chromsci/bmu095 ER - TY - JOUR T1 - PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML AN - 1701480068; PQ0001733817 AB - The transcription factor PU.1, encoded by the murine Sfpi1 gene (SPI1 in humans), is a member of the Ets transcription factor family and plays a vital role in commitment and maturation of the myeloid and lymphoid lineages. Murine studies directly link primary acute myeloid leukaemia (AML) and decreased PU.1 expression in specifically modified strains. Similarly, a radiation-induced chromosome 2 deletion and subsequent Sfpi1 point mutation in the remaining allele lead to murine radiation-induced AML. Consistent with murine data, heterozygous deletion of the SPI1 locus and mutation of the -14kb SPI1 upstream regulatory element were described previously in human primary AML, although they are rare events. Other mechanisms linked to PU.1 downregulation in human AML include TP53 deletion, FLT3-ITD mutation and the recurrent AML1-ETO [t(8; 21)] and PML-RARA [t(15; 17)] translocations. This review provides an up-to-date overview on our current understanding of the involvement of PU.1 in the initiation and development of radiation-induced AML, together with recommendations for future murine and human studies. JF - Carcinogenesis AU - Verbiest, Tom AU - Bouffler, Simon AU - Nutt, Stephen L AU - Badie, Christophe Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 413 EP - 419 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 36 IS - 4 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Molecular modelling KW - Data processing KW - Regulatory sequences KW - Point mutation KW - chromosome 2 KW - p53 protein KW - ETS protein KW - Gene deletion KW - Chromosome translocations KW - Reviews KW - Transcription factors KW - Carcinogenesis KW - Chromosome deletion KW - PU.1 protein KW - X 24500:Reviews, Legislation, Book & Conference Notices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701480068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=PU.1+downregulation+in+murine+radiation-induced+acute+myeloid+leukaemia+%28AML%29%3A+from+molecular+mechanism+to+human+AML&rft.au=Verbiest%2C+Tom%3BBouffler%2C+Simon%3BNutt%2C+Stephen+L%3BBadie%2C+Christophe&rft.aulast=Verbiest&rft.aufirst=Tom&rft.date=2015-04-01&rft.volume=36&rft.issue=4&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/10.1093%2Fcarcin%2Fbgv016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Data processing; Regulatory sequences; Point mutation; chromosome 2; ETS protein; p53 protein; Gene deletion; Chromosome translocations; Transcription factors; Reviews; Chromosome deletion; Carcinogenesis; PU.1 protein DO - http://dx.doi.org/10.1093/carcin/bgv016 ER - TY - JOUR T1 - Laser 3D Printing with Sub-Microscale Resolution of Porous Elastomeric Scaffolds for Supporting Human Bone Stem Cells AN - 1694976188; PQ0001663752 AB - A reproducible method is needed to fabricate 3D scaffold constructs that results in periodic and uniform structures with precise control at sub-micrometer and micrometer length scales. In this study, fabrication of scaffolds by two-photon polymerization (2PP) of a biodegradable urethane and acrylate-based photoelastomer is demonstrated. This material supports 2PP processing with sub-micrometer spatial resolution. The high photoreactivity of the biophotoelastomer permits 2PP processing at a scanning speed of 1000 mm s super(-1), facilitating rapid fabrication of relatively large structures (>5 mm super(3)). These structures are custom printed for in vitro assay screening in 96-well plates and are sufficiently flexible to enable facile handling and transplantation. These results indicate that stable scaffolds with porosities of greater than 60% can be produced using 2PP. Human bone marrow stromal cells grown on 3D scaffolds exhibit increased growth and proliferation compared to smooth 2D scaffold controls. 3D scaffolds adsorb larger amounts of protein than smooth 2D scaffolds due to their larger surface area; the scaffolds also allow cells to attach in multiple planes and to completely infiltrate the porous scaffolds. The flexible photoelastomer material is biocompatible in vitro and is associated with facile handling, making it a viable candidate for further study of complex 3D-printed scaffolds. The fabrication of scaffolds by two-photon polymerization (2PP) of a biodegradable urethane and acrylate-based photoelastomer is demonstrated. This material supports 2PP processing with sub-micrometer spatial resolution. The high photoreactivity of the biophoto-elastomer permits 2PP processing at a scanning speed of 1000 mm s super(-1), facilitating rapid fabrication of large structures (>5 mm super(3)). Stable scaffolds with porosities of greater than 60% can be produced using 2PP. JF - Advanced Healthcare Materials AU - Petrochenko, Peter E AU - Torgersen, Jan AU - Gruber, Peter AU - Hicks, Lucas A AU - Zheng, Jiwen AU - Kumar, Girish AU - Narayan, Roger J AU - Goering, Peter L AU - Liska, Robert AU - Stampfl, Juergen AU - Ovsianikov, Aleksandr AD - Office of Science and Engineering Laboratories, U.S. Food and Drug Administration (FDA), Silver Spring, MD, USA. Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 739 EP - 747 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 4 IS - 5 SN - 2192-2640, 2192-2640 KW - Toxicology Abstracts; Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Polymerization KW - Printing KW - stromal cells KW - Surface area KW - Porosity KW - Bone marrow KW - spatial discrimination KW - Biodegradability KW - Elastomers KW - scaffolds KW - Stem cells KW - Scanning KW - Lasers KW - Cell proliferation KW - urethane KW - X 24390:Radioactive Materials KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694976188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Healthcare+Materials&rft.atitle=Laser+3D+Printing+with+Sub-Microscale+Resolution+of+Porous+Elastomeric+Scaffolds+for+Supporting+Human+Bone+Stem+Cells&rft.au=Petrochenko%2C+Peter+E%3BTorgersen%2C+Jan%3BGruber%2C+Peter%3BHicks%2C+Lucas+A%3BZheng%2C+Jiwen%3BKumar%2C+Girish%3BNarayan%2C+Roger+J%3BGoering%2C+Peter+L%3BLiska%2C+Robert%3BStampfl%2C+Juergen%3BOvsianikov%2C+Aleksandr&rft.aulast=Petrochenko&rft.aufirst=Peter&rft.date=2015-04-01&rft.volume=4&rft.issue=5&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=Advanced+Healthcare+Materials&rft.issn=21922640&rft_id=info:doi/10.1002%2Fadhm.201400442 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Printing; Polymerization; stromal cells; Surface area; Porosity; Bone marrow; spatial discrimination; Elastomers; Biodegradability; scaffolds; Stem cells; Scanning; Lasers; Cell proliferation; urethane DO - http://dx.doi.org/10.1002/adhm.201400442 ER - TY - JOUR T1 - How Long Can Stool Samples Be Fixed for an Accurate Diagnosis of Soil-Transmitted Helminth Infection Using Mini-FLOTAC? AN - 1685635907 AB - Background Kato-Katz is a widely used method for the diagnosis of soil-transmitted helminth infection. Fecal samples cannot be preserved, and hence, should be processed on the day of collection and examined under a microscope within 60 min of slide preparation. Mini-FLOTAC is a technique that allows examining fixed fecal samples. We assessed the performance of Mini-FLOTAC using formalin-fixed stool samples compared to Kato-Katz and determined the dynamics of prevalence and intensity estimates of soil-transmitted helminth infection over a 31-day time period. Methodology The study was carried out in late 2013 on Pemba Island, Tanzania. Forty-one children were enrolled and stool samples were subjected on the day of collection to a single Kato-Katz thick smear and Mini-FLOTAC examination; 12 aliquots of stool were fixed in 5% formalin and subsequently examined by Mini-FLOTAC up to 31 days after collection. Principal Findings The combined results from Kato-Katz and Mini-FLOTAC revealed that 100% of children were positive for Trichuris trichiura, 85% for Ascaris lumbricoides, and 54% for hookworm. Kato-Katz and Mini-FLOTAC techniques found similar prevalence estimates for A. lumbricoides (85% versus 76%), T. trichiura (98% versus 100%), and hookworm (42% versus 51%). The mean eggs per gram of stool (EPG) according to Kato-Katz and Mini-FLOTAC was 12,075 and 11,679 for A. lumbricoides, 1,074 and 1,592 for T. trichiura, and 255 and 220 for hookworm, respectively. The mean EPG from day 1 to 31 of fixation was stable for A. lumbricoides and T. trichiura, but gradually declined for hookworm, starting at day 15. Conclusions/Significance The findings of our study suggest that for a qualitative diagnosis of soil-transmitted helminth infection, stool samples can be fixed in 5% formalin for at least 30 days. However, for an accurate quantitative diagnosis of hookworm, we suggest a limit of 15 days of preservation. Our results have direct implication for integrating soil-transmitted helminthiasis into transmission assessment surveys for lymphatic filariasis. JF - PLoS Neglected Tropical Diseases AU - Barda, Beatrice AU - Albonico, Marco AU - Ianniello, Davide AU - Ame, Shaali M AU - Keiser, Jennifer AU - Speich, Benjamin AU - Rinaldi, Laura AU - Cringoli, Giuseppe AU - Burioni, Roberto AU - Montresor, Antonio AU - Utzinger, Jürg Y1 - 2015/04// PY - 2015 DA - Apr 2015 CY - San Francisco PB - Public Library of Science VL - 9 IS - 4 KW - Medical Sciences--Communicable Diseases KW - Laboratories KW - Public health KW - Studies KW - Infections KW - Tropical diseases KW - Eggs KW - Parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1685635907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=How+Long+Can+Stool+Samples+Be+Fixed+for+an+Accurate+Diagnosis+of+Soil-Transmitted+Helminth+Infection+Using+Mini-FLOTAC%3F%3A+e0003698&rft.au=Barda%2C+Beatrice%3BAlbonico%2C+Marco%3BIanniello%2C+Davide%3BAme%2C+Shaali+M%3BKeiser%2C+Jennifer%3BSpeich%2C+Benjamin%3BRinaldi%2C+Laura%3BCringoli%2C+Giuseppe%3BBurioni%2C+Roberto%3BMontresor%2C+Antonio%3BUtzinger%2C+J%C3%BCrg&rft.aulast=Barda&rft.aufirst=Beatrice&rft.date=2015-04-01&rft.volume=9&rft.issue=4&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pntd.0003698 LA - English DB - ProQuest Central N1 - Name - World Health Organization N1 - Copyright - © 2015 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Barda B, Albonico M, Ianniello D, Ame SM, Keiser J, Speich B, et al. (2015) How Long Can Stool Samples Be Fixed for an Accurate Diagnosis of Soil-Transmitted Helminth Infection Using Mini-FLOTAC? PLoS Negl Trop Dis 9(4): e0003698. doi:10.1371/journal.pntd.0003698 N1 - Last updated - 2015-06-04 DO - http://dx.doi.org/10.1371/journal.pntd.0003698 ER - TY - JOUR T1 - Estimating the Benefits of Public Health Policies that Reduce Harmful Consumption AN - 1683503391 AB - For products such as tobacco and junk food, where policy interventions are often designed to decrease consumption, affected consumers gain utility from improvements in lifetime health and longevity but also lose utility associated with the activity of consuming the product. In the case of anti-smoking policies, even though published estimates of gross health and longevity benefits are up to 900 times higher than the net consumer benefits suggested by a more direct willingness-to-pay estimation approach, there is little recognition in the cost-benefit and cost-effectiveness literature that gross estimates will overstate intrapersonal welfare improvements when utility losses are not netted out. This paper presents a general framework for analyzing policies that are designed to reduce inefficiently high consumption and provides a rule of thumb for the relationship between net and gross consumer welfare effects: where there exists a plausible estimate of the tax that would allow consumers to fully internalize health costs, the ratio of the tax to the per-unit long-term cost can provide an upper bound on the ratio of net to gross benefits. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Health Economics AU - Ashley, Elizabeth M AU - Nardinelli, Clark AU - Lavaty, Rosemarie A AD - Food and Drug Administration, Silver Spring, MD, USA. ; Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 617 EP - 624 CY - York PB - Wiley Subscription Services, Inc. VL - 24 IS - 5 SN - 1057-9230 KW - Business And Economics--Economic Situation And Conditions KW - Consumer behaviour KW - Benefits KW - Cessation KW - Public domain KW - Public health KW - Smoking KW - Taxation KW - Tobacco KW - Welfare effects KW - Willingness to pay KW - Consumers KW - Cost benefit analysis KW - Cost effectiveness KW - Food consumption KW - Health costs KW - Healthy food KW - Interventions KW - Longevity KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683503391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Economics&rft.atitle=Estimating+the+Benefits+of+Public+Health+Policies+that+Reduce+Harmful+Consumption&rft.au=Ashley%2C+Elizabeth+M%3BNardinelli%2C+Clark%3BLavaty%2C+Rosemarie+A&rft.aulast=Ashley&rft.aufirst=Elizabeth&rft.date=2015-04-01&rft.volume=24&rft.issue=5&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Health+Economics&rft.issn=10579230&rft_id=info:doi/10.1002%2Fhec.3040 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright John Wiley & Sons, Inc. Apr 2015 N1 - Date revised - 2015-04-15 N1 - Last updated - 2016-11-17 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1002/hec.3040 ER - TY - JOUR T1 - Elastography: history, principles, and technique comparison AN - 1680434828; PQ0001477701 AB - Elastography is a relatively new imaging technology that creates images of tissue stiffness. It can be thought of an extension of the ancient technique of palpation but it gives better spatial localization information and is less subjective. Two main types of elastography are currently in use, strain elastography where the tissue displacement in response to gentle pressure is used to compute and image tissue strain, and shear wave elastography where the speed of shear waves traversing tissue is measured and used to create an image of tissue stiffness. Each method has advantages and disadvantages but generally strain imaging is excellent for focal lesions and shear wave imaging, being more quantitative, is best for diffuse organ diseases. Strain imaging requires additional training in acquisition technique to obtain high quality images. Pitfalls to avoid and tips for good images are provided. Improvements in strain imaging are focused on better quality indicators and better methods for quantification. Improvements in shear wave imaging will be higher frame rates, greater accuracy in focal lesions, and making results more comparable between different ultrasound systems. Both methods will continue to improve and will provide ever more powerful new tools for diagnosis of diffuse and focal diseases. JF - Abdominal Imaging AU - Garra, Brian S AD - Washington DC VA Medical Center, Washington, DC, USA, brian.garra@fda.hhs.gov Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 680 EP - 697 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 40 IS - 4 SN - 0942-8925, 0942-8925 KW - Biotechnology and Bioengineering Abstracts KW - Waves KW - spatial discrimination KW - Pressure KW - imaging KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680434828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abdominal+Imaging&rft.atitle=Elastography%3A+history%2C+principles%2C+and+technique+comparison&rft.au=Garra%2C+Brian+S&rft.aulast=Garra&rft.aufirst=Brian&rft.date=2015-04-01&rft.volume=40&rft.issue=4&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=Abdominal+Imaging&rft.issn=09428925&rft_id=info:doi/10.1007%2Fs00261-014-0305-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 41 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - spatial discrimination; Waves; Pressure; Ultrasound; imaging DO - http://dx.doi.org/10.1007/s00261-014-0305-8 ER - TY - JOUR T1 - Sequence of Pathogenic Events in Cynomolgus Macaques Infected with Aerosolized Monkeypox Virus AN - 1676353749; PQ0001421923 AB - To evaluate new vaccines when human efficacy studies are not possible, the FDA's "Animal Rule" requires well-characterized models of infection. Thus, in the present study, the early pathogenic events of monkeypox infection in nonhuman primates, a surrogate for variola virus infection, were characterized. Cynomolgus macaques were exposed to aerosolized monkeypox virus (105 PFU). Clinical observations, viral loads, immune responses, and pathological changes were examined on days 2, 4, 6, 8, 10, and 12 postchallenge. Viral DNA (vDNA) was detected in the lungs on day 2 postchallenge, and viral antigen was detected, by immunostaining, in the epithelium of bronchi, bronchioles, and alveolar walls. Lesions comprised rare foci of dysplastic and sloughed cells in respiratory bronchioles. By day 4, vDNA was detected in the throat, tonsil, and spleen, and monkeypox antigen was detected in the lung, hilar and submandibular lymph nodes, spleen, and colon. Lung lesions comprised focal epithelial necrosis and inflammation. Body temperature peaked on day 6, pox lesions appeared on the skin, and lesions, with positive immunostaining, were present in the lung, tonsil, spleen, lymph nodes, and colon. By day 8, vDNA was present in 9/13 tissues. Blood concentrations of interleukin 1ra (IL-1ra), IL-6, and gamma interferon (IFN- gamma ) increased markedly. By day 10, circulating IgG antibody concentrations increased, and on day 12, animals showed early signs of recovery. These results define early events occurring in an inhalational macaque monkeypox infection model, supporting its use as a surrogate model for human smallpox. IMPORTANCE Bioterrorism poses a major threat to public health, as the deliberate release of infectious agents, such smallpox or a related virus, monkeypox, would have catastrophic consequences. The development and testing of new medical countermeasures, e.g., vaccines, are thus priorities; however, tests for efficacy in humans cannot be performed because it would be unethical and field trials are not feasible. To overcome this, the FDA may grant marketing approval of a new product based upon the "Animal Rule," in which interventions are tested for efficacy in well-characterized animal models. Monkeypox virus infection of nonhuman primates (NHPs) presents a potential surrogate disease model for smallpox. Previously, the later stages of monkeypox infection were defined, but the early course of infection remains unstudied. Here, the early pathogenic events of inhalational monkeypox infection in NHPs were characterized, and the results support the use of this surrogate model for testing human smallpox interventions. JF - Journal of Virology AU - Tree, J A AU - Hall, G AU - Pearson, G AU - Rayner, E AU - Graham, V A AU - Steeds, K AU - Bewley, K R AU - Hatch, G J AU - Dennis, M AU - Taylor, I Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 4335 EP - 4344 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 8 SN - 0022-538X, 0022-538X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Interleukin 6 KW - gamma -Interferon KW - Pharynx KW - Body temperature KW - bioterrorism KW - Animal models KW - Intervention KW - Infection KW - Interleukin 1 receptor antagonist KW - Public health KW - Necrosis KW - Colon KW - Tonsil KW - Bronchus KW - Marketing KW - Lesions KW - Cynomolgus KW - Epithelium KW - Monkeypox virus KW - Variola virus KW - Monkeypox KW - Macaca KW - Disasters KW - Temperature KW - Spleen KW - Bioterrorism KW - Primates KW - Alveoli KW - Lymph nodes KW - Inflammation KW - Smallpox KW - Blood KW - Skin diseases KW - Lung KW - FDA KW - DNA KW - Immunoglobulin G KW - Priorities KW - Vaccines KW - Immune response KW - V 22350:Immunology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676353749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Sequence+of+Pathogenic+Events+in+Cynomolgus+Macaques+Infected+with+Aerosolized+Monkeypox+Virus&rft.au=Tree%2C+J+A%3BHall%2C+G%3BPearson%2C+G%3BRayner%2C+E%3BGraham%2C+V+A%3BSteeds%2C+K%3BBewley%2C+K+R%3BHatch%2C+G+J%3BDennis%2C+M%3BTaylor%2C+I&rft.aulast=Tree&rft.aufirst=J&rft.date=2015-04-01&rft.volume=89&rft.issue=8&rft.spage=4335&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.03029-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 33 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Interleukin 6; gamma -Interferon; Pharynx; Body temperature; bioterrorism; Animal models; Infection; Interleukin 1 receptor antagonist; Public health; Necrosis; Bronchus; Tonsil; Colon; Epithelium; Monkeypox; Spleen; Lymph nodes; Alveoli; Inflammation; Smallpox; Blood; Skin diseases; Lung; Immunoglobulin G; DNA; Immune response; Vaccines; Temperature; Disasters; Intervention; Bioterrorism; Primates; Marketing; FDA; Lesions; Priorities; Macaca; Cynomolgus; Variola virus; Monkeypox virus DO - http://dx.doi.org/10.1128/JVI.03029-14 ER - TY - JOUR T1 - The Transient Dermal Exposure II: Post-Exposure Absorption and Evaporation of Volatile Compounds AN - 1673384597; PQ0001281705 AB - The transient dermal exposure is one where the skin is exposed to chemical for a finite duration, after which the chemical is removed and no residue remains on the skin's surface. Chemical within the skin at the end of the exposure period can still enter the systemic circulation. If it has some volatility, a portion of it will evaporate from the surface before it has a chance to be absorbed by the body. The fate of this post-exposure "skin depot" is the focus of this theoretical study. Laplace domain solutions for concentration distribution, flux, and cumulative mass absorption and evaporation are presented, and time domain results are obtained through numerical inversion. The Final Value Theorem is applied to obtain the analytical solutions for the total fractional absorption by the body and evaporation from skin at infinite time following a transient exposure. The solutions depend on two dimensionless variables: chi , the ratio of evaporation rate to steady-state dermal permeation rate; and the ratio of exposure time to membrane lag time. Simple closed form algebraic equations are presented that closely approximate the complete analytical solutions. Applications of the theory to the dermal risk assessment of pharmaceutical, occupational, and environmental exposures are presented for four example chemicals. copyright 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:1499-1507, 2015 JF - Journal of Pharmaceutical Sciences AU - Frasch, HFrederick AU - Bunge, Annette L AD - Health Effects Laboratory, National Institute for Occupational Safety and Health, Morgantown, West Virginia, 26505. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 1499 EP - 1507 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 4 SN - 0022-3549, 0022-3549 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Membranes KW - Skin KW - Mathematical models KW - Residues KW - Evaporation KW - Uncertainty KW - Volatiles KW - Inversion KW - Absorption KW - Pharmaceuticals KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673384597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=The+Transient+Dermal+Exposure+II%3A+Post-Exposure+Absorption+and+Evaporation+of+Volatile+Compounds&rft.au=Frasch%2C+HFrederick%3BBunge%2C+Annette+L&rft.aulast=Frasch&rft.aufirst=HFrederick&rft.date=2015-04-01&rft.volume=104&rft.issue=4&rft.spage=1499&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Risk assessment; Mathematical models; Skin; Inversion; Volatiles; Evaporation; Pharmaceuticals; Occupational exposure; Uncertainty; Membranes; Residues; Absorption DO - http://dx.doi.org/10.1002/jps.24334 ER - TY - JOUR T1 - Sex hormone modulation of both induction and inhibition of CYP1A by genistein in HepG2/C3A cells. AN - 1671210105; 25479735 AB - Genistein is a widely consumed phytoestrogen in dietary supplements and has been reported to play roles in both cancer prevention and promotion. These conflicting effects may be complicated by sex differences. Cytochrome P450 1A (CYP1A) participates in carcinogen activation and detoxification, and the enzyme may interact with genistein. Therefore, modulation of CYP1A by a combination of genistein and sex hormones could be responsible for sex differences related to cancer prevention and promotion. In the current study, a human liver cell line, HepG2/C3A, cultured in sex hormone-supplemented media was used to investigate the modulatory effect of genistein on CYP1A gene expression and activity. Genistein exerted both long-term (72 h) induction and short-term (immediate) inhibition of CYP1A activity in HepG2/C3A cells. In the long-term study, CYP1A gene expression and enzyme activity were induced to a greater extent in male hormone-supplemented cells than female ones. In the short-term study, CYP1A activity was inhibited more strongly by genistein in the male hormone-supplemented cells than in the female hormone-supplemented cells. These significant differences suggest that male hormones can modulate the effects of genistein on CYP1A gene expression and activity. JF - In vitro cellular & developmental biology. Animal AU - Liu, Yitong AU - Santillo, Michael F AU - Flynn, Thomas J AU - Ferguson, Martine S AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA, yitong.liu@fda.hhs.gov. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 426 EP - 431 VL - 51 IS - 4 KW - Benzoflavones KW - 0 KW - Gonadal Steroid Hormones KW - Testosterone KW - 3XMK78S47O KW - alpha-naphthoflavone KW - 604-59-1 KW - beta-Naphthoflavone KW - 6051-87-2 KW - Genistein KW - DH2M523P0H KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1A1 protein, human KW - CYP1A2 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1A2 KW - Index Medicus KW - Cytochrome P-450 CYP1A1 -- genetics KW - Testosterone -- pharmacology KW - Cytochrome P-450 CYP1A2 -- genetics KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Humans KW - beta-Naphthoflavone -- pharmacology KW - Hep G2 Cells -- drug effects KW - Male KW - Female KW - Benzoflavones -- pharmacology KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Gonadal Steroid Hormones -- pharmacology KW - Genistein -- pharmacology KW - Aryl Hydrocarbon Hydroxylases -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671210105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vitro+cellular+%26+developmental+biology.+Animal&rft.atitle=Sex+hormone+modulation+of+both+induction+and+inhibition+of+CYP1A+by+genistein+in+HepG2%2FC3A+cells.&rft.au=Liu%2C+Yitong%3BSantillo%2C+Michael+F%3BFlynn%2C+Thomas+J%3BFerguson%2C+Martine+S&rft.aulast=Liu&rft.aufirst=Yitong&rft.date=2015-04-01&rft.volume=51&rft.issue=4&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=In+vitro+cellular+%26+developmental+biology.+Animal&rft.issn=1543-706X&rft_id=info:doi/10.1007%2Fs11626-014-9848-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-25 N1 - Date created - 2015-04-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s11626-014-9848-9 ER - TY - JOUR T1 - Global analysis of posttranscriptional gene expression in response to sodium arsenite. AN - 1669841604; 25493608 AB - Inorganic arsenic species are potent environmental toxins and causes of numerous health problems. Most studies have assumed that arsenic-induced changes in mRNA levels result from effects on gene transcription. We evaluated the prevalence of changes in mRNA stability in response to sodium arsenite in human fibroblasts. We used microarray analyses to determine changes in steady-state mRNA levels and mRNA decay rates following 24-hr exposure to noncytotoxic concentrations of sodium arsenite, and we confirmed some of these changes using real-time reverse-transcription polymerase chain reaction (RT-PCR). In arsenite-exposed cells, 186 probe set-identified transcripts were significantly increased and 167 were significantly decreased. When decay rates were analyzed after actinomycin D treatment, only 4,992 (9.1%) of probe set-identified transcripts decayed by > 25% after 4 hr. Of these, 70 were among the 353 whose steady-state levels were altered by arsenite, and of these, only 4 exhibited significantly different decay rates between arsenite and control treatment. Real-time RT-PCR confirmed a major, significant arsenite-induced stabilization of the mRNA encoding δ aminolevulinate synthase 1 (ALAS1), the rate-limiting enzyme in heme biosynthesis. This change presumably accounted for at least part of the 2.7-fold increase in steady-state ALAS1 mRNA levels seen after arsenite treatment. This could reflect decreases in cellular heme caused by the massive induction by arsenite of heme oxygenase mRNA (HMOX1; 68-fold increase), the rate-limiting enzyme in heme catabolism. We conclude that arsenite modification of mRNA stability is relatively uncommon, but in some instances can result in significant changes in gene expression. JF - Environmental health perspectives AU - Qiu, Lian-Qun AU - Abey, Sarah AU - Harris, Shawn AU - Shah, Ruchir AU - Gerrish, Kevin E AU - Blackshear, Perry J AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 324 EP - 330 VL - 123 IS - 4 KW - Arsenites KW - 0 KW - Environmental Pollutants KW - RNA, Messenger KW - Sodium Compounds KW - Dactinomycin KW - 1CC1JFE158 KW - sodium arsenite KW - 48OVY2OC72 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - 5-Aminolevulinate Synthetase KW - EC 2.3.1.37 KW - Index Medicus KW - Dactinomycin -- pharmacology KW - Cells, Cultured KW - Humans KW - Male KW - Fibroblasts -- drug effects KW - Environmental Pollutants -- toxicity KW - Heme Oxygenase-1 -- metabolism KW - Arsenites -- toxicity KW - Sodium Compounds -- toxicity KW - 5-Aminolevulinate Synthetase -- metabolism KW - 5-Aminolevulinate Synthetase -- genetics KW - Heme Oxygenase-1 -- genetics KW - Gene Expression Regulation -- drug effects KW - Fibroblasts -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669841604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Global+analysis+of+posttranscriptional+gene+expression+in+response+to+sodium+arsenite.&rft.au=Qiu%2C+Lian-Qun%3BAbey%2C+Sarah%3BHarris%2C+Shawn%3BShah%2C+Ruchir%3BGerrish%2C+Kevin+E%3BBlackshear%2C+Perry+J&rft.aulast=Qiu&rft.aufirst=Lian-Qun&rft.date=2015-04-01&rft.volume=123&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=1552-9924&rft_id=info:doi/10.1289%2Fehp.1408626 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-27 N1 - Date created - 2015-04-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):557-64 [15996700] Bioinformatics. 2005 Oct 15;21(20):3933-4 [16109745] Cancer Res. 2005 Dec 1;65(23):10977-83 [16322246] Nucleic Acids Res. 2006;34(2):485-95 [16421274] Toxicol Appl Pharmacol. 2006 Nov 1;216(3):407-15 [16876216] Mol Cell Biol. 2006 Dec;26(24):9196-208 [17030620] Biostatistics. 2007 Apr;8(2):414-32 [16928955] Tohoku J Exp Med. 2007 Sep;213(1):1-16 [17785948] J Cell Physiol. 2008 Mar;214(3):796-809 [17849448] Exp Biol Med (Maywood). 2008 Mar;233(3):377-84 [18296743] Toxicol Appl Pharmacol. 2008 Mar 15;227(3):400-16 [18191166] Environ Health Perspect. 2008 Apr;116(4):524-31 [18414638] Cytokine Growth Factor Rev. 2008 Jun-Aug;19(3-4):245-51 [18524667] Toxicol Appl Pharmacol. 2008 Dec 15;233(3):389-403 [18929588] Toxicol In Vitro. 2009 Feb;23(1):148-57 [19000923] BMC Genomics. 2010;11:282 [20444259] Arch Toxicol. 2010 Aug;84(8):585-96 [20502880] J Appl Toxicol. 2011 Mar;31(2):95-107 [21321970] BMC Genomics. 2011;12:173 [21457566] BMC Biol. 2011;9:34 [21627854] J Biol Chem. 2011 Jul 29;286(30):26424-30 [21659532] Toxicol Sci. 2011 Oct;123(2):305-32 [21750349] Biol Pharm Bull. 2011;34(11):1748-52 [22040890] J Immunol. 2012 May 15;188(10):5150-9 [22491258] Toxicol Lett. 2012 Jul 20;212(2):169-79 [22641096] J Biol Chem. 2000 May 19;275(20):15336-42 [10809768] Hepatology. 2001 May;33(5):1217-22 [11343251] Toxicol Sci. 2001 Jun;61(2):314-20 [11353140] Carcinogenesis. 2002 May;23(5):867-76 [12016162] Science. 2002 Jun 21;296(5576):2143-5 [12077387] Toxicol Lett. 2002 Jul 7;133(1):33-45 [12076508] Nucleic Acids Res. 2001 May 1;29(9):e45 [11328886] Environ Health Perspect. 2002 Oct;110 Suppl 5:883-6 [12426152] Carcinogenesis. 2003 Apr;24(4):747-56 [12727804] Toxicol Lett. 2003 Jul 20;143(2):155-62 [12749819] Mol Cell Biochem. 2004 Jan;255(1-2):57-66 [14971646] Toxicol Appl Pharmacol. 2004 Aug 1;198(3):394-404 [15276419] J Cell Biol. 1971 Sep;50(3):746-61 [4398631] Cancer Res. 1973 Nov;33(11):2658-61 [4748426] Cancer Res. 1989 Jul 15;49(14):3776-82 [2736519] Mol Cell Biol. 1990 Sep;10(9):4967-9 [2388632] Folia Med Cracov. 1993;34(1-4):29-47 [8175062] Environ Health Perspect. 1998 Aug;106 Suppl 4:1005-15 [9703486] Methods Mol Biol. 2013;1064:91-100 [23996251] Nat Rev Immunol. 2014 Jun;14(6):361-76 [24854588] RNA Biol. 2014;11(8):1019-30 [25531407] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1289/ehp.1408626 ER - TY - JOUR T1 - FDA approval: idelalisib monotherapy for the treatment of patients with follicular lymphoma and small lymphocytic lymphoma. AN - 1669831515; 25645861 AB - On July 23, 2014, the FDA granted accelerated approval to idelalisib (Zydelig tablets; Gilead Sciences, Inc.) for the treatment of patients with relapsed follicular B-cell non-Hodgkin lymphoma or relapsed small lymphocytic lymphoma (SLL) who have received at least two prior systemic therapies. In a multicenter, single-arm trial, 123 patients with relapsed indolent non-Hodgkin lymphomas received idelalisib, 150 mg orally twice daily. In patients with follicular lymphoma, the overall response rate (ORR) was 54%, and the median duration of response (DOR) was not evaluable; median follow-up was 8.1 months. In patients with SLL, the ORR was 58% and the median DOR was 11.9 months. One-half of patients experienced a serious adverse reaction of pneumonia, pyrexia, sepsis, febrile neutropenia, diarrhea, or pneumonitis. Other common adverse reactions were abdominal pain, nausea, fatigue, cough, dyspnea, and rash. Common treatment-emergent laboratory abnormalities were elevations in alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, absolute lymphocytes, and triglycerides. Continued approval may be contingent upon verification of clinical benefit in confirmatory trials. ©2015 American Association for Cancer Research. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Miller, Barry W AU - Przepiorka, Donna AU - de Claro, R Angelo AU - Lee, Kyung AU - Nie, Lei AU - Simpson, Natalie AU - Gudi, Ramadevi AU - Saber, Haleh AU - Shord, Stacy AU - Bullock, Julie AU - Marathe, Dhananjay AU - Mehrotra, Nitin AU - Hsieh, Li Shan AU - Ghosh, Debasis AU - Brown, Janice AU - Kane, Robert C AU - Justice, Robert AU - Kaminskas, Edvardas AU - Farrell, Ann T AU - Pazdur, Richard AD - Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Barry.Miller@fda.hhs.gov. ; Office of Hematology and Oncology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Pharmaceutical Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Y1 - 2015/04/01/ PY - 2015 DA - 2015 Apr 01 SP - 1525 EP - 1529 VL - 21 IS - 7 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Purines KW - Quinazolinones KW - Class I Phosphatidylinositol 3-Kinases KW - EC 2.7.1.137 KW - Index Medicus KW - Humans KW - Quinazolinones -- therapeutic use KW - Leukemia, Lymphocytic, Chronic, B-Cell -- drug therapy KW - Class I Phosphatidylinositol 3-Kinases -- antagonists & inhibitors KW - Lymphoma, Follicular -- drug therapy KW - Purines -- therapeutic use KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669831515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=FDA+approval%3A+idelalisib+monotherapy+for+the+treatment+of+patients+with+follicular+lymphoma+and+small+lymphocytic+lymphoma.&rft.au=Miller%2C+Barry+W%3BPrzepiorka%2C+Donna%3Bde+Claro%2C+R+Angelo%3BLee%2C+Kyung%3BNie%2C+Lei%3BSimpson%2C+Natalie%3BGudi%2C+Ramadevi%3BSaber%2C+Haleh%3BShord%2C+Stacy%3BBullock%2C+Julie%3BMarathe%2C+Dhananjay%3BMehrotra%2C+Nitin%3BHsieh%2C+Li+Shan%3BGhosh%2C+Debasis%3BBrown%2C+Janice%3BKane%2C+Robert+C%3BJustice%2C+Robert%3BKaminskas%2C+Edvardas%3BFarrell%2C+Ann+T%3BPazdur%2C+Richard&rft.aulast=Miller&rft.aufirst=Barry&rft.date=2015-04-01&rft.volume=21&rft.issue=7&rft.spage=1525&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-2522 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-02 N1 - Date created - 2015-04-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment On: Clin Cancer Res. 2015 Apr 1;21(7):1537-42 [25670221] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-2522 ER - TY - JOUR T1 - Detection and characterization of SiO2 and TiO2 nanostructures in dietary supplements. AN - 1669453325; 25738207 AB - Nanomaterials are beginning to enter our daily lives through various consumer products as the result of technology commercialization. The development of methodologies to detect the presence of nanomaterials in consumer products is an essential element in understanding our exposure. In this study, we have developed methods for the separation and characterization of silicon dioxide (SiO2) and titanium dioxide (TiO2) nanostructures in dietary supplements marketed in products specifically targeted for women. A total of 12 commercial products claiming the inclusion of SiO2 and TiO2, but not making any claims regarding the particle size, were randomly selected for purchase through various retailers. To isolate nanostructures from these products, a simple methodology that combines acid digestion and centrifugation was utilized. Once isolated, the chemical composition, size, morphology, and crystal structure were characterized using mass spectroscopy, light scattering, electron microscopy, and X-ray diffraction techniques. SiO2 and TiO2 nanostructures were detected in 11 of 12 products using these methods. Many of the isolated nanoscale materials showed a high degree of aggregation; however, identified individual structures had at least one dimension below 100 nm. These robust methods can be used for routine monitoring of commercial products for nanoscale oxides of silica and titanium. JF - Journal of agricultural and food chemistry AU - Lim, Jin-Hee AU - Sisco, Patrick AU - Mudalige, Thilak K AU - Sánchez-Pomales, Germarie AU - Howard, Paul C AU - Linder, Sean W AD - †Office of Regulatory Affairs, Arkansas Regional Laboratory, and ‡National Center for Toxicological Research, Office of Scientific Coordination, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, United States. Y1 - 2015/04/01/ PY - 2015 DA - 2015 Apr 01 SP - 3144 EP - 3152 VL - 63 IS - 12 KW - titanium dioxide KW - 15FIX9V2JP KW - Silicon Dioxide KW - 7631-86-9 KW - Titanium KW - D1JT611TNE KW - Index Medicus KW - dietary supplements KW - nanomaterials KW - silicon dioxide KW - nanotechnology KW - X-Ray Diffraction KW - Nanostructures -- chemistry KW - Titanium -- chemistry KW - Dietary Supplements -- analysis KW - Silicon Dioxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669453325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Detection+and+characterization+of+SiO2+and+TiO2+nanostructures+in+dietary+supplements.&rft.au=Lim%2C+Jin-Hee%3BSisco%2C+Patrick%3BMudalige%2C+Thilak+K%3BS%C3%A1nchez-Pomales%2C+Germarie%3BHoward%2C+Paul+C%3BLinder%2C+Sean+W&rft.aulast=Lim&rft.aufirst=Jin-Hee&rft.date=2015-04-01&rft.volume=63&rft.issue=12&rft.spage=3144&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Facs.jafc.5b00392 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-29 N1 - Date created - 2015-04-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/acs.jafc.5b00392 ER - TY - GEN T1 - Secondary pharmacology data to assess potential off-target activity of new drugs: a regulatory perspective. AN - 1669448821; 25792260 JF - Nature reviews. Drug discovery AU - Papoian, Thomas AU - Chiu, Haw-Jyh AU - Elayan, Ikram AU - Jagadeesh, Gowraganahalli AU - Khan, Imran AU - Laniyonu, Adebayo A AU - Li, Cindy Xinguang AU - Saulnier, Muriel AU - Simpson, Natalie AU - Yang, Baichun Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 294 VL - 14 IS - 4 KW - Index Medicus KW - Animals KW - Off-Label Use KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Cost-Benefit Analysis KW - Structure-Activity Relationship KW - Pharmacology, Clinical -- trends KW - Legislation, Drug -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669448821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Nature+reviews.+Drug+discovery&rft.atitle=Secondary+pharmacology+data+to+assess+potential+off-target+activity+of+new+drugs%3A+a+regulatory+perspective.&rft.au=Papoian%2C+Thomas%3BChiu%2C+Haw-Jyh%3BElayan%2C+Ikram%3BJagadeesh%2C+Gowraganahalli%3BKhan%2C+Imran%3BLaniyonu%2C+Adebayo+A%3BLi%2C+Cindy+Xinguang%3BSaulnier%2C+Muriel%3BSimpson%2C+Natalie%3BYang%2C+Baichun&rft.aulast=Papoian&rft.aufirst=Thomas&rft.date=2015-04-01&rft.volume=14&rft.issue=4&rft.spage=294&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Drug+discovery&rft.issn=1474-1784&rft_id=info:doi/10.1038%2Fnrd3845-c1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-01 N1 - Date created - 2015-04-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/nrd3845-c1 ER - TY - JOUR T1 - Trends in worker hearing loss by industry sector, 1981-2010 AN - 1668258093; PQ0001248720 AB - Background The purpose of this study was to estimate the incidence and prevalence of hearing loss for noise-exposed U.S. workers by industry sector and 5-year time period, covering 30 years. Methods Audiograms for 1.8 million workers from 1981-2010 were examined. Incidence and prevalence were estimated by industry sector and time period. The adjusted risk of incident hearing loss within each time period and industry sector as compared with a reference time period was also estimated. Results The adjusted risk for incident hearing loss decreased over time when all industry sectors were combined. However, the risk remained high for workers in Healthcare and Social Assistance, and the prevalence was consistently high for Mining and Construction workers. Conclusions While progress has been made in reducing the risk of incident hearing loss within most industry sectors, additional efforts are needed within Mining, Construction and Healthcare and Social Assistance. Am. J. Ind. Med. 58:392-401, 2015. copyright 2015 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Masterson, Elizabeth A AU - Deddens, James A AU - Themann, Christa L AU - Bertke, Stephen AU - Calvert, Geoffrey M AD - National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 392 EP - 401 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 4 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Health care KW - Hearing loss KW - Mining KW - Risk reduction KW - Construction industry KW - H 1000:Occupational Safety and Health KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668258093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Trends+in+worker+hearing+loss+by+industry+sector%2C+1981-2010&rft.au=Masterson%2C+Elizabeth+A%3BDeddens%2C+James+A%3BThemann%2C+Christa+L%3BBertke%2C+Stephen%3BCalvert%2C+Geoffrey+M&rft.aulast=Masterson&rft.aufirst=Elizabeth&rft.date=2015-04-01&rft.volume=58&rft.issue=4&rft.spage=392&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22429 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-29 N1 - SubjectsTermNotLitGenreText - Health care; Risk reduction; Mining; Hearing loss; Construction industry DO - http://dx.doi.org/10.1002/ajim.22429 ER - TY - JOUR T1 - Persistence of furan-induced epigenetic aberrations in the livers of F344 rats. AN - 1667352139; 25539665 AB - Furan is a heterocyclic organic compound produced in the chemical manufacturing industry and also found in a broad range of food products, including infant formulas and baby foods. Previous reports have indicated that the adverse biological effects of furan, including its liver tumorigenicity, may be associated with epigenetic abnormalities. In the present study, we investigated the persistence of epigenetic alterations in rat liver. Male F344 rats were treated by gavage 5 days per week with 8 mg furan/kg body weight (bw)/day for 90 days. After the last treatment, rats were divided randomly into 4 groups; 1 group of rats was sacrificed 24 h after the last treatment, whereas other groups were maintained without further furan treatment for an additional 90, 180, or 360 days. Treatment with furan for 90 days resulted in alterations in histone lysine methylation and acetylation, induction of base-excision DNA repair genes, suggesting oxidative damage to DNA, and changes in the gene expression in the livers. A majority of these furan-induced molecular changes was transient and disappeared after the cessation of furan treatment. In contrast, histone H3 lysine 9 and H3 lysine 56 showed a sustained and time-depended decrease in acetylation, which was associated with formation of heterochromatin and altered gene expression. These results indicate that furan-induced adverse effects may be mechanistically related to sustained changes in histone lysine acetylation that compromise the ability of cells to maintain and control properly the expression of genetic information. Published by Oxford University Press on behalf of the Society of Toxicology 2014. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - de Conti, Aline AU - Kobets, Tetyana AU - Tryndyak, Volodymyr AU - Burnett, Sarah D AU - Han, Tao AU - Fuscoe, James C AU - Beland, Frederick A AU - Doerge, Daniel R AU - Pogribny, Igor P AD - *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079. ; *Division of Biochemical Toxicology and Division of Systems Biology, National Center for Toxicological Research, Jefferson, Arkansas 72079 igor.pogribny@fda.hhs.gov. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 217 EP - 226 VL - 144 IS - 2 KW - Furans KW - 0 KW - Histones KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - microarrays KW - liver carcinogenesis KW - gene expression profiling KW - genetic toxicology KW - Rats KW - Gene Expression Profiling KW - Animals KW - Acetylation KW - Rats, Inbred F344 KW - DNA Damage KW - Histones -- metabolism KW - Histones -- chemistry KW - Methylation KW - Male KW - Lysine -- metabolism KW - Liver -- drug effects KW - Furans -- toxicity KW - Epigenesis, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667352139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Persistence+of+furan-induced+epigenetic+aberrations+in+the+livers+of+F344+rats.&rft.au=de+Conti%2C+Aline%3BKobets%2C+Tetyana%3BTryndyak%2C+Volodymyr%3BBurnett%2C+Sarah+D%3BHan%2C+Tao%3BFuscoe%2C+James+C%3BBeland%2C+Frederick+A%3BDoerge%2C+Daniel+R%3BPogribny%2C+Igor+P&rft.aulast=de+Conti&rft.aufirst=Aline&rft.date=2015-04-01&rft.volume=144&rft.issue=2&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu313 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-14 N1 - Date created - 2015-03-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Crit Rev Toxicol. 2012 Jul;42(6):491-500 [22568498] Breast Cancer Res Treat. 2012 Jun;133(2):649-57 [22042362] Nat Cell Biol. 2012 Nov;14(11):1203-11 [23041974] Mol Cell. 2012 Nov 30;48(4):532-46 [23084836] Toxicol Sci. 2013 Jan;131(1):40-55 [23024176] Toxicol Sci. 2013 Oct;135(2):369-79 [23853263] Toxicol Appl Pharmacol. 2014 Jan 1;274(1):63-77 [24183702] Toxicol Sci. 2014 Jun;139(2):371-80 [24614236] Int J Cancer. 2014 Oct 15;135(8):1860-8 [24623538] Int J Cancer. 2014 Nov 1;135(9):2014-23 [24691920] Nucleic Acids Res. 2000 Jan 1;28(1):27-30 [10592173] Trends Genet. 2002 May;18(5):252-8 [12047950] Science. 2003 Aug 8;301(5634):798-802 [12907790] In Silico Biol. 2003;3(3):235-40 [12954087] Cancer Res. 2004 Feb 1;64(3):1050-7 [14871837] Cancer Res. 2004 Jun 1;64(11):3871-7 [15172996] J Agric Food Chem. 2004 Nov 3;52(22):6830-6 [15506823] CRC Crit Rev Food Sci Nutr. 1979;11(4):355-400 [378551] Carcinogenesis. 1986 May;7(5):689-95 [2870822] Carcinogenesis. 1993 Apr;14(4):551-7 [8472313] Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1361-5 [8108416] IARC Monogr Eval Carcinog Risks Hum. 1995;63:393-407 [9097102] Toxicology. 1997 Mar 28;118(2-3):195-204 [9129173] Cell Mol Life Sci. 1998 Jan;54(1):21-31 [9487384] J Natl Cancer Inst. 1999 Aug 4;91(15):1288-94 [10433617] Biochem Biophys Res Commun. 1999 Sep 7;262(3):624-8 [10471374] Cancer Lett. 2005 Nov 8;229(1):1-11 [16157213] Mutat Res. 2006 Jan 29;593(1-2):80-7 [16144704] J Biol Chem. 2008 Feb 15;283(7):4051-60 [18065415] Nat Protoc. 2008;3(6):1101-8 [18546601] Cancer Invest. 2008 Jul;26(6):575-82 [18584348] Mutat Res. 2008 Jul-Aug;659(1-2):40-8 [18407786] Exp Toxicol Pathol. 2009 Mar;61(2):101-11 [18809303] Methods Mol Biol. 2009;563:379-98 [19597796] Ann Surg Oncol. 2009 Sep;16(9):2555-64 [19548033] Am J Pathol. 2009 Oct;175(4):1653-61 [19717643] Curr Protoc Mol Biol. 2010 Jan;Chapter 21:Unit 21.17.1-16 [20069538] Toxicol Pathol. 2010 Feb;38(2):230-43 [20124500] Cancer Res. 2010 Sep 1;70(17):6968-77 [20713525] Environ Health Perspect. 2010 Nov;118(11):1597-602 [20562052] Nature. 2011 May 5;473(7345):43-9 [21441907] PLoS Genet. 2011 Nov;7(11):e1002376 [22102830] Toxicology. 2012 Feb 26;292(2-3):63-70 [22079235] Free Radic Biol Med. 2012 Feb 15;52(4):735-46 [22206977] J Trace Elem Med Biol. 2012 Jun;26(2-3):174-8 [22633395] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu313 ER - TY - JOUR T1 - A beating heart cell model to predict cardiotoxicity: effects of the dietary supplement ingredients higenamine, phenylethylamine, ephedrine and caffeine. AN - 1666293487; 25684415 AB - Some dietary supplements may contain cardiac stimulants and potential cardiotoxins. In vitro studies may identify ingredients of concern. A beating human cardiomyocyte cell line was used to evaluate cellular effects following phenylethylamine (PEA), higenamine, ephedrine or caffeine treatment. PEA and higenamine exposure levels simulated published blood levels in humans or animals after intravenous administration. Ephedrine and caffeine levels approximated published blood levels following human oral intake. At low or midrange levels, each chemical was examined plus or minus 50 µM caffeine, simulating human blood levels reported after consumption of caffeine-enriched dietary supplements. To measure beats per minute (BPM), peak width, etc., rhythmic rise and fall in intracellular calcium levels following 30 min of treatment was examined. Higenamine 31.3 ng/ml or 313 ng/ml significantly increased BPM in an escalating manner. PEA increased BPM at 0.8 and 8 µg/ml, while 80 µg/ml PEA reduced BPM and widened peaks. Ephedrine produced a significant BPM dose response from 0.5 to 5.0 µM. Caffeine increased BPM only at a toxic level of 250 µM. Adding caffeine to PEA or higenamine but not ephedrine further increased BPM. These in vitro results suggest that additional testing may be warranted in vivo to further evaluate these effects. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Calvert, Richard AU - Vohra, Sanah AU - Ferguson, Martine AU - Wiesenfeld, Paddy AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, 8301 Muirkirk Rd., Laurel, MD 20708, USA. Electronic address: richard.calvert@fda.hhs.gov. ; U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Applied Research and Safety Assessment, Division of Toxicology, 8301 Muirkirk Rd., Laurel, MD 20708, USA. ; U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Management, Division of Mathematics, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 207 EP - 213 VL - 78 KW - Alkaloids KW - 0 KW - Cardiotonic Agents KW - Phenethylamines KW - Tetrahydroisoquinolines KW - Caffeine KW - 3G6A5W338E KW - Ephedrine KW - GN83C131XS KW - higenamine KW - TBV5O16GAP KW - Index Medicus KW - Higenamine KW - iCell cardiomyocytes KW - Cardiac effects KW - Phenylethylamine KW - Rats KW - Animals KW - Cardiotonic Agents -- toxicity KW - Cardiotoxicity -- pathology KW - Cells, Cultured KW - Humans KW - Toxicity Tests KW - Heart -- drug effects KW - Myocytes, Cardiac -- drug effects KW - Phenethylamines -- toxicity KW - Caffeine -- toxicity KW - Dietary Supplements -- toxicity KW - Alkaloids -- toxicity KW - Ephedrine -- toxicity KW - Tetrahydroisoquinolines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1666293487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=A+beating+heart+cell+model+to+predict+cardiotoxicity%3A+effects+of+the+dietary+supplement+ingredients+higenamine%2C+phenylethylamine%2C+ephedrine+and+caffeine.&rft.au=Calvert%2C+Richard%3BVohra%2C+Sanah%3BFerguson%2C+Martine%3BWiesenfeld%2C+Paddy&rft.aulast=Calvert&rft.aufirst=Richard&rft.date=2015-04-01&rft.volume=78&rft.issue=&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2015.01.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-17 N1 - Date created - 2015-03-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2015.01.022 ER - TY - JOUR T1 - Chiral resolution and absolute configuration of the enantiomers of the psychoactive "designer drug" 3,4-methylenedioxypyrovalerone. AN - 1664774469; 25727807 AB - Illicit rac-MDPV (3,4-methylenedioxypyrovalerone), manufactured in clandestine labs, has become widely abused for its cocaine-like stimulant properties. It has recently been found as one of the toxic materials in the so-called "bath salts," producing, among other effects, psychosis and tachycardia in humans when introduced by any of the several routes of administration (e.g., intravenous, oral, etc.). The considerable toxicity of this "designer drug" probably resides in one of the enantiomers of the racemate. In order to obtain a sufficient amount of the enantiomers of rac-MDPV to determine their activity, we improved the known synthesis of rac-MDPV and found chemical resolving agents, (+)- and (-)-2'-bromotetranilic acid, that gave the MDPV enantiomers in >96% enantiomeric excess as determined by (1) H nuclear magnetic resonance and chiral high-performance liquid chromatography. The absolute stereochemistry of these enantiomers was determined by single-crystal X-ray diffraction studies. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Chirality AU - Suzuki, Masaki AU - Deschamps, Jeffrey R AU - Jacobson, Arthur E AU - Rice, Kenner C AD - Drug Design and Synthesis Section, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 287 EP - 293 VL - 27 IS - 4 KW - 3,4-methylenedioxypyrovalerone KW - 0 KW - Benzodioxoles KW - Designer Drugs KW - Psychotropic Drugs KW - Pyrrolidines KW - Hydrochloric Acid KW - QTT17582CB KW - Index Medicus KW - euphoric stimulant KW - bath salts KW - designer drug KW - synthesis KW - non-chromatographic chiral resolution KW - 3,4-methylenedioxypyrovalerone (MDPV) KW - Stereoisomerism KW - Hydrochloric Acid -- chemistry KW - Limit of Detection KW - Pyrrolidines -- analysis KW - Psychotropic Drugs -- isolation & purification KW - Designer Drugs -- isolation & purification KW - Psychotropic Drugs -- chemistry KW - Pyrrolidines -- chemistry KW - Benzodioxoles -- isolation & purification KW - Benzodioxoles -- analysis KW - Psychotropic Drugs -- analysis KW - Pyrrolidines -- isolation & purification KW - Benzodioxoles -- chemistry KW - Designer Drugs -- chemistry KW - Designer Drugs -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664774469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chirality&rft.atitle=Chiral+resolution+and+absolute+configuration+of+the+enantiomers+of+the+psychoactive+%22designer+drug%22+3%2C4-methylenedioxypyrovalerone.&rft.au=Suzuki%2C+Masaki%3BDeschamps%2C+Jeffrey+R%3BJacobson%2C+Arthur+E%3BRice%2C+Kenner+C&rft.aulast=Suzuki&rft.aufirst=Masaki&rft.date=2015-04-01&rft.volume=27&rft.issue=4&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Chirality&rft.issn=1520-636X&rft_id=info:doi/10.1002%2Fchir.22423 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-30 N1 - Date created - 2015-03-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/chir.22423 ER - TY - JOUR T1 - Analysis of Bacillus cereus toxicity using PCR, ELISA and a lateral flow device. AN - 1664442587; 25627167 AB - The aim of this study was to evaluate the performance of immunodetection methods and PCR analysis of enterotoxigenic Bacillus cereus strains. Eighty-eight enterotoxigenic B. cereus group strains linked to food-borne outbreaks and illnesses were studied with 30 exclusivity nonenterotoxigenic strains including Bacillus amyoliquifaciens, Bacillus subtilis, Staphylococcus aureus, Salmonella and Escherichia coli for this assessment. The PCR results showed 80% agreement with immunoassays for the Nhe target and 84% for the Hbl product. All exclusivity strains were PCR and serologically negative. PCR has proven to be a valuable tool when used in conjunction with immunoassays to quickly identify enterotoxigenic B. cereus group strains. This study assessed the utility of rapid methods to characterize enterotoxigenic profiles of B. cereus group strains. The identification of enterotoxigenic bacteria and any associated toxins detected from food products is essential in food defense programs as public health officials search for methods to rapidly and accurately screen a global food supply. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied microbiology AU - Tallent, S M AU - Hait, J M AU - Bennett, R W AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 1068 EP - 1075 VL - 118 IS - 4 KW - Bacterial Proteins KW - 0 KW - Bacterial Toxins KW - Enterotoxins KW - Hemolysin Proteins KW - NheA protein, Bacillus cereus KW - enterotoxin, Bacillus cereus KW - hemolysin BL protein, Bacillus KW - Index Medicus KW - food-borne illness KW - detection KW - food poisoning KW - enterotoxigenic KW - Bacillus cereus KW - Bacterial Toxins -- genetics KW - Bacterial Proteins -- genetics KW - Bacterial Toxins -- analysis KW - Hemolysin Proteins -- analysis KW - Humans KW - Hemolysin Proteins -- genetics KW - Bacterial Proteins -- analysis KW - Enterotoxins -- genetics KW - Bacillus -- genetics KW - Polymerase Chain Reaction KW - Food Microbiology KW - Enzyme-Linked Immunosorbent Assay KW - Bacillus cereus -- genetics KW - Bacillus cereus -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664442587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+microbiology&rft.atitle=Analysis+of+Bacillus+cereus+toxicity+using+PCR%2C+ELISA+and+a+lateral+flow+device.&rft.au=Tallent%2C+S+M%3BHait%2C+J+M%3BBennett%2C+R+W&rft.aulast=Tallent&rft.aufirst=S&rft.date=2015-04-01&rft.volume=118&rft.issue=4&rft.spage=1068&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+microbiology&rft.issn=1365-2672&rft_id=info:doi/10.1111%2Fjam.12766 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-30 N1 - Date created - 2015-03-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/jam.12766 ER - TY - JOUR T1 - Water management decision makers' evaluations of uncertainty in a decision support system: the case of WaterSim in the decision theater AN - 1663902207; 4654427 AB - Model-based decision support systems are increasingly used to link knowledge to action for environmental decision making. How stakeholders perceive uncertainty in models and visualisations affects their perceptions of credibility, relevance and usability of these tools. This paper presents a case study of water decision makers' evaluations of WaterSim, a dynamic water simulation model presented in an immersive decision theatre environment. Results reveal that decision makers' understandings of uncertainty in their evaluations of decision support systems reflect both scientific and political discourse. We conclude with recommendations for design and evaluation of decision support systems that incorporate decision makers' views. Reprinted by permission of Carfax Publishing, Taylor & Francis Ltd. JF - Journal of environmental planning and management AU - White, Dave D AU - Wutich, Amber Y AU - Larson, Kelli L AU - Lant, Tim AD - Arizona State University ; US Department of Health and Human Services Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 616 EP - 630 VL - 58 IS - 4 SN - 0964-0568, 0964-0568 KW - Economics KW - U.S.A. KW - Uncertainty KW - Decision making KW - Stakeholder KW - Water management KW - Arizona KW - Climate change KW - Modelling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1663902207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+planning+and+management&rft.atitle=Water+management+decision+makers%27+evaluations+of+uncertainty+in+a+decision+support+system%3A+the+case+of+WaterSim+in+the+decision+theater&rft.au=White%2C+Dave+D%3BWutich%2C+Amber+Y%3BLarson%2C+Kelli+L%3BLant%2C+Tim&rft.aulast=White&rft.aufirst=Dave&rft.date=2015-04-01&rft.volume=58&rft.issue=4&rft.spage=616&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+planning+and+management&rft.issn=09640568&rft_id=info:doi/10.1080%2F09640568.2013.875892 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-03-16 N1 - Last updated - 2015-03-17 N1 - SubjectsTermNotLitGenreText - 2382 2381 8560 9511 4309 4313; 8162 8163; 13472 7625; 3322 6071 1542 11325; 13078; 12158; 25 433 293 14 DO - http://dx.doi.org/10.1080/09640568.2013.875892 ER - TY - JOUR T1 - Prescription opioids. III. Disposition of oxycodone in oral fluid and blood following controlled single-dose administration. AN - 1663899164; 25589778 AB - Oxycodone (OC) is recommended to be included as an analyte tested in the proposed Substance Abuse and Mental Health Services Administration (SAMHSA's) Mandatory Guidelines for Federal Workplace Drug Testing Programs using Oral Fluid (OF) Specimens. This study demonstrates the time course of OC and metabolites, noroxycodone (NOC), oxymorphone (OM) and noroxymorphone (NOM), in near-simultaneous paired OF and whole blood (BL) specimens by liquid chromatography-tandem mass spectrometry (LC-MS-MS) (limit of detection = 1 ng/mL OF, 5 ng/mL BL). A single dose of OC 20 mg controlled-release was administered to 12 healthy subjects followed by specimen collections for 52 h. Analyte prevalence was as follows: OF, OC > NOC > OM; and BL, OC > NOC > NOM. OC and NOC were frequently detected within 15-30 min in OF and 30 min to 2 h in BL. NOM and OM appeared between 1.5-5 h post-dose. The mean OF-to-BL (OF:BL) ratios and correlations were 5.4 for OC (r = 0.719) and 1.0 for NOC (r = 0.651). The period of detection for OF exceeded BL by ∼2-fold at similar cutoff concentrations. At a 1 ng/mL cutoff for OF, the mean detection time was 34 h for OC and NOC. These data provide new information that should facilitate interpretation of OC test results. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Journal of analytical toxicology AU - Cone, Edward J AU - DePriest, Anne Z AU - Heltsley, Rebecca AU - Black, David L AU - Mitchell, John M AU - LoDico, Charles AU - Flegel, Ron AD - Johns Hopkins School of Medicine, Baltimore, MD, USA. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA anne.depriest@aegislabs.com. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA. ; Aegis Sciences Corporation, 515 Great Circle Road, Nashville, TN 37228, USA Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, TN, USA. ; RTI International, Research Triangle Park, NC, USA. ; Division of Workplace Programs (DWP), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 192 EP - 202 VL - 39 IS - 3 KW - Analgesics, Opioid KW - 0 KW - Delayed-Action Preparations KW - Prescription Drugs KW - Oxycodone KW - CD35PMG570 KW - Index Medicus KW - Administration, Oral KW - Occupational Health KW - Drug Administration Schedule KW - Biotransformation KW - Humans KW - Chromatography, Liquid KW - Workplace KW - Tissue Distribution KW - Tandem Mass Spectrometry KW - Oxycodone -- blood KW - Analgesics, Opioid -- blood KW - Prescription Drugs -- administration & dosage KW - Saliva -- chemistry KW - Oxycodone -- pharmacokinetics KW - Oxycodone -- administration & dosage KW - Analgesics, Opioid -- pharmacokinetics KW - Prescription Drugs -- pharmacokinetics KW - Analgesics, Opioid -- administration & dosage KW - Prescription Drugs -- analysis KW - Substance Abuse Detection -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1663899164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Prescription+opioids.+III.+Disposition+of+oxycodone+in+oral+fluid+and+blood+following+controlled+single-dose+administration.&rft.au=Cone%2C+Edward+J%3BDePriest%2C+Anne+Z%3BHeltsley%2C+Rebecca%3BBlack%2C+David+L%3BMitchell%2C+John+M%3BLoDico%2C+Charles%3BFlegel%2C+Ron&rft.aulast=Cone&rft.aufirst=Edward&rft.date=2015-04-01&rft.volume=39&rft.issue=3&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbku176 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-03 N1 - Date created - 2015-03-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bku176 ER - TY - JOUR T1 - Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes. AN - 1662638218; 25510677 AB - Multi-walled carbon nanotubes (MWCNT) are new materials with a wide range of industrial and commercial applications. However, their nano-scaled size and fiber-like shape render them respirable and potentially fibrogenic if inhaled into the lungs. To understand MWCNT fibrogenesis, we analyzed the pathologic and molecular aspects of the early phase response to MWCNT in mouse lungs. MWCNT induced rapid and pronounced lesions in the lungs characterized by increased cellularity and formation of fibrotic foci, most notably near where MWCNT deposited, within 14 days post-exposure. Deposition of collagen fibers was markedly increased in the alveolar septa and fibrotic foci, accompanied by elevated expression of fibrotic genes Col1a1, Col1a2, and Fn1 at both mRNA and protein levels. Fibrosis was induced rapidly at 40 μg, wherein fibrotic changes were detected on day 1 and reached a maximal intensity on day 7 through day 14. Induction of fibrosis was dose-dependent at the dose range of 5-40 μg, 7 days post-exposure. MWCNT elicited rapid and prominent infiltrations of neutrophils and macrophages alongside fibrosis implicating acute inflammation in the fibrotic response. At the molecular level, MWCNT induced elevated expression of proinflammatory cytokines TNFα, IL1α, IL1β, IL6, and CCL2 in lung tissues as well as the bronchoalveolar lavage fluid, in a dose- and time-dependent manner. MWCNT also increased the expression of fibrogenic growth factors TGF-β1 and PDGF-A in the lungs significantly. These findings underscore the interplay between acute inflammation and the early fibrotic response in the initiation and propagation of pulmonary fibrosis induced by MWCNT. JF - Archives of toxicology AU - Dong, Jie AU - Porter, Dale W AU - Batteli, Lori A AU - Wolfarth, Michael G AU - Richardson, Diana L AU - Ma, Qiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV, 26505, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 621 EP - 633 VL - 89 IS - 4 KW - Collagen Type I KW - 0 KW - Cytokines KW - Fibronectins KW - Nanotubes, Carbon KW - alpha 2(I) collagen KW - collagen type I, alpha 1 chain KW - Index Medicus KW - Cytokines -- analysis KW - Animals KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Mice, Inbred C57BL KW - Fibronectins -- genetics KW - Collagen Type I -- genetics KW - Time Factors KW - Bronchoalveolar Lavage Fluid -- cytology KW - Male KW - Lung -- immunology KW - Pulmonary Fibrosis -- immunology KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Lung -- drug effects KW - Lung -- pathology KW - Lung -- metabolism KW - Nanotubes, Carbon -- toxicity KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1662638218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Pathologic+and+molecular+profiling+of+rapid-onset+fibrosis+and+inflammation+induced+by+multi-walled+carbon+nanotubes.&rft.au=Dong%2C+Jie%3BPorter%2C+Dale+W%3BBatteli%2C+Lori+A%3BWolfarth%2C+Michael+G%3BRichardson%2C+Diana+L%3BMa%2C+Qiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2015-04-01&rft.volume=89&rft.issue=4&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-014-1428-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-14 N1 - Date created - 2015-03-11 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00204-014-1428-y ER - TY - JOUR T1 - Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress. AN - 1661994566; 25301065 AB - Dual control of cellular heme levels by extracellular scavenger proteins and degradation by heme oxygenases is essential in diseases associated with increased heme release. During severe hemolysis or rhabdomyolysis, uncontrolled heme exposure can cause acute kidney injury and endothelial cell damage. The toxicity of heme was primarily attributed to its pro-oxidant effects; however additional mechanisms of heme toxicity have not been studied systematically. In addition to redox reactivity, heme may adversely alter cellular functions by binding to essential proteins and impairing their function. We studied inducible heme oxygenase (Hmox1)-deficient mouse embryo fibroblast cell lines as a model to systematically explore adaptive and disruptive responses that were triggered by intracellular heme levels exceeding the homeostatic range. We extensively characterized the proteome phenotype of the cellular heme stress responses by quantitative mass spectrometry of stable isotope-labeled cells that covered more than 2000 individual proteins. The most significant signals specific to heme toxicity were consistent with oxidative stress and impaired protein degradation by the proteasome. This ultimately led to an activation of the response to unfolded proteins. These observations were explained mechanistically by demonstrating binding of heme to the proteasome that was linked to impaired proteasome function. Oxidative heme reactions and proteasome inhibition could be differentiated as synergistic activities of the porphyrin. Based on the present data a novel model of cellular heme toxicity is proposed, whereby proteasome inhibition by heme sustains a cycle of oxidative stress, protein modification, accumulation of damaged proteins and cell death. JF - Cell death and differentiation AU - Vallelian, F AU - Deuel, J W AU - Opitz, L AU - Schaer, C A AU - Puglia, M AU - Lönn, M AU - Engelsberger, W AU - Schauer, S AU - Karnaukhova, E AU - Spahn, D R AU - Stocker, R AU - Buehler, P W AU - Schaer, D J AD - Division of Internal Medicine, University of Zurich, CH-8091 Zurich, Switzerland. ; Functional Genomics Center Zurich, Swiss Federal Institute of Technology Zurich/University of Zurich, Zurich, Switzerland. ; 1] Division of Internal Medicine, University of Zurich, CH-8091 Zurich, Switzerland [2] Institute of Anesthesiology, University of Zurich, Zurich, Switzerland. ; 1] Division of Internal Medicine, University of Zurich, CH-8091 Zurich, Switzerland [2] Functional Genomics Center Zurich, Swiss Federal Institute of Technology Zurich/University of Zurich, Zurich, Switzerland. ; School of Medical Sciences, Discipline of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia. ; Laboratory of Biochemistry and Vascular Biology, Center of Biologics Evaluation and Research (CBER), FDA, Bethesda, MD, USA. ; Institute of Anesthesiology, University of Zurich, Zurich, Switzerland. ; 1] School of Medical Sciences, Discipline of Pathology and Bosch Institute, University of Sydney, Sydney, New South Wales, Australia [2] Victor Chang Cardiac Research Institute and University of New South Wales, Sydney, New South Wales, Australia. ; 1] Division of Internal Medicine, University of Zurich, CH-8091 Zurich, Switzerland [2] Center of Evolutionary Medicine, University of Zurich, Zurich, Switzerland. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 597 EP - 611 VL - 22 IS - 4 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Heat-Shock Proteins KW - Membrane Proteins KW - Proteasome Inhibitors KW - Sequestosome-1 Protein KW - Sqstm1 protein, mouse KW - Ubiquitin KW - Heme KW - 42VZT0U6YR KW - Bortezomib KW - 69G8BD63PP KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Hmox1 protein, mouse KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Animals KW - Proteasome Inhibitors -- pharmacology KW - Membrane Proteins -- metabolism KW - HEK293 Cells KW - Humans KW - Bortezomib -- pharmacology KW - Spectrophotometry, Ultraviolet KW - Circular Dichroism KW - Mice KW - Heme Oxygenase-1 -- genetics KW - Membrane Proteins -- genetics KW - Mice, Inbred BALB C KW - Protein Binding KW - Mice, Knockout KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Ubiquitin -- metabolism KW - Cell Survival -- drug effects KW - Heme Oxygenase-1 -- metabolism KW - Cell Line KW - Proteasome Endopeptidase Complex -- metabolism KW - Proteasome Endopeptidase Complex -- chemistry KW - Oxidative Stress -- drug effects KW - Heme -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1661994566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+death+and+differentiation&rft.atitle=Proteasome+inhibition+and+oxidative+reactions+disrupt+cellular+homeostasis+during+heme+stress.&rft.au=Vallelian%2C+F%3BDeuel%2C+J+W%3BOpitz%2C+L%3BSchaer%2C+C+A%3BPuglia%2C+M%3BL%C3%B6nn%2C+M%3BEngelsberger%2C+W%3BSchauer%2C+S%3BKarnaukhova%2C+E%3BSpahn%2C+D+R%3BStocker%2C+R%3BBuehler%2C+P+W%3BSchaer%2C+D+J&rft.aulast=Vallelian&rft.aufirst=F&rft.date=2015-04-01&rft.volume=22&rft.issue=4&rft.spage=597&rft.isbn=&rft.btitle=&rft.title=Cell+death+and+differentiation&rft.issn=1476-5403&rft_id=info:doi/10.1038%2Fcdd.2014.154 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-25 N1 - Date created - 2015-03-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Pharmacol Rev. 2008 Mar;60(1):79-127 [18323402] Biol Chem. 2008 Mar;389(3):203-9 [18208355] J Proteome Res. 2010 Aug 6;9(8):4061-70 [20568812] Trends Mol Med. 2010 Oct;16(10):447-57 [20708968] Blood. 2010 Dec 9;116(24):5347-56 [20739658] Antioxid Redox Signal. 2011 Oct 15;15(8):2265-99 [21314436] Blood. 2012 Mar 8;119(10):2368-75 [22262768] Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1394-409 [22245770] J Neuroinflammation. 2012;9:46 [22394415] J Am Chem Soc. 2012 Jun 27;134(25):10451-7 [22642538] Blood. 2013 Feb 21;121(8):1276-84 [23264591] Cold Spring Harb Perspect Med. 2013 Jun;3(6). pii: a013433. doi: 10.1101/cshperspect.a013433 [23645855] Cell Death Differ. 2013 Nov;20(11):1569-79 [23995229] Antioxid Redox Signal. 2013 Nov 10;19(14):1619-33 [23418677] J Clin Invest. 2013 Nov;123(11):4809-20 [24084741] J Proteomics. 2014 Apr 4;100:147-59 [24200835] Mol Cell Proteomics. 2002 May;1(5):376-86 [12118079] Blood. 2002 Aug 1;100(3):879-87 [12130498] Biochem J. 1979 May 1;179(2):281-9 [486081] Eur J Biochem. 1990 Jul 31;191(2):275-80 [2200671] Trans Assoc Am Physicians. 1990;103:174-9 [2132529] Eur J Biochem. 1992 Jun 1;206(2):567-78 [1317798] J Clin Invest. 1992 Jul;90(1):267-70 [1634613] Trans Assoc Am Physicians. 1992;105:1-6 [1308986] Proc Natl Acad Sci U S A. 1993 Oct 15;90(20):9285-9 [8415693] J Biol Chem. 1996 Dec 20;271(51):32538-45 [8955078] J Cell Biol. 1998 Dec 28;143(7):1883-98 [9864362] J Clin Invest. 1999 Jan;103(1):129-35 [9884342] J Biol Chem. 1999 Jan 29;274(5):2616-24 [9915789] J Cell Sci. 2006 Jan 15;119(Pt 2):303-13 [16390870] FASEB J. 2006 Mar;20(3):562-4 [16410344] Biochim Biophys Acta. 2006 Sep;1762(9):819-27 [16935474] J Leukoc Biol. 2008 Feb;83(2):325-33 [17947394] J Clin Invest. 2009 Aug;119(8):2271-80 [19620788] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/cdd.2014.154 ER - TY - JOUR T1 - The impact of recent cocaine use on plasma levels of methadone and buprenorphine in patients with and without HIV-infection. AN - 1660437527; 25480096 AB - Cocaine decreases methadone and buprenorphine plasma concentrations. HIV infection and/or antiretroviral medication use may impact these relationships. We sought to determine the association between recent cocaine use and methadone and buprenorphine concentrations in HIV-infected and uninfected subjects in clinical care. R- and S-methadone or buprenorphine and norbuprenorphine concentrations were assessed at 0.5, 1, 2, and 24 hours after dosing in subjects with confirmed cocaine use and abstinence. We compared methadone and buprenorphine concentrations for cocaine use vs. abstinence, by HIV status in 16 subjects receiving methadone (6 HIV-infected) and 17 receiving buprenorphine (8 HIV-infected). With recent cocaine use, peak R-methadone (244 vs. 297 ng/mL, p = 0.03) and peak S-methadone (285 vs. 339 ng/mL); p = 0.03 concentrations were lower in HIV-uninfected subjects only. Peak buprenorphine and norbuprenorphine concentrations were unchanged regardless of cocaine use or HIV status. Cocaine may decrease methadone concentrations in HIV-uninfected subjects. HIV infection or its treatment may attenuate cocaine's effect on methadone. Copyright © 2015 Elsevier Inc. All rights reserved. JF - Journal of substance abuse treatment AU - Tetrault, Jeanette M AU - McCance-Katz, Elinore F AU - Moody, David E AU - Fiellin, David A AU - Lruie, Bonnie S AU - DInh, An T AU - Fiellin, Lynn E AD - Department of Internal Medicine. Yale University School of Medicine, New Haven, CT, USA. Electronic address: jeanette.tetrault@yale.edu. ; Substance Abuse and Mental Health Services Administration, Rockville, MD, USA. ; Center for Human Toxicology, University of Utah, Salt Lake City, UT, USA. ; Department of Internal Medicine. Yale University School of Medicine, New Haven, CT, USA; Center for Interdisciplinary Research on AIDS, Yale University School of Public Health, New Haven, CT, USA; Investigative Medicine Program, Yale University School of Medicine, New Haven, CT, USA. ; Department of Internal Medicine. Yale University School of Medicine, New Haven, CT, USA. Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 70 EP - 74 VL - 51 KW - Anti-HIV Agents KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - norbuprenorphine KW - 7E53B4O073 KW - Cocaine KW - I5Y540LHVR KW - Methadone KW - UC6VBE7V1Z KW - Index Medicus KW - Stereoisomerism KW - Drug Interactions KW - Anti-HIV Agents -- therapeutic use KW - Humans KW - Adult KW - Opiate Substitution Treatment -- methods KW - Opioid-Related Disorders -- rehabilitation KW - Middle Aged KW - Time Factors KW - Cocaine -- administration & dosage KW - Male KW - Female KW - HIV Infections -- complications KW - Methadone -- chemistry KW - Buprenorphine -- pharmacokinetics KW - HIV Infections -- drug therapy KW - Methadone -- pharmacokinetics KW - Buprenorphine -- administration & dosage KW - Methadone -- administration & dosage KW - Buprenorphine -- analogs & derivatives KW - Cocaine-Related Disorders -- complications KW - Buprenorphine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660437527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+substance+abuse+treatment&rft.atitle=The+impact+of+recent+cocaine+use+on+plasma+levels+of+methadone+and+buprenorphine+in+patients+with+and+without+HIV-infection.&rft.au=Tetrault%2C+Jeanette+M%3BMcCance-Katz%2C+Elinore+F%3BMoody%2C+David+E%3BFiellin%2C+David+A%3BLruie%2C+Bonnie+S%3BDInh%2C+An+T%3BFiellin%2C+Lynn+E&rft.aulast=Tetrault&rft.aufirst=Jeanette&rft.date=2015-04-01&rft.volume=51&rft.issue=&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Journal+of+substance+abuse+treatment&rft.issn=1873-6483&rft_id=info:doi/10.1016%2Fj.jsat.2014.10.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-01 N1 - Date created - 2015-03-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jsat.2014.10.010 ER - TY - JOUR T1 - Comparison of eight different agars for the recovery of clinically relevant non-O157 Shiga toxin-producing Escherichia coli from baby spinach, cilantro, alfalfa sprouts and raw milk AN - 1647018857; 21290782 AB - The FDA Bacteriological Analytical Manual (BAM) Chapter 4a recommends several agars for isolating non-O157 Shiga toxin-producing Escherichia coli (STEC); not all have been thoroughly tested for recovering STECs from food. Using E. coli strains representing ten clinically relevant O serogroups (O26, O45, O91, O103, O104, O111, O113, O121, O128, O145) in artificially-contaminated fresh produce - bagged baby spinach, alfalfa sprouts, cilantro, and raw milk - we evaluated the performance of 8 different agars. Performance was highly dependent upon strain used and the presence of inhibitors, but not necessarily dependent on food matrix. Tellurite resistant-negative strains, O91:-, O103:H6, O104:H21, O113:H21, and O128, grew poorly on CHROMagar STEC, Rainbow agar O157, and a modified Rainbow O157 (mRB) agar. Although adding washed sheep's blood to CHROMagar STEC and mRB agars improved overall performance; however, this also reversed the inhibition of non-target bacteria provided by original formulations. Variable colony coloration made selecting colonies from Rainbow agar O157 and mRB agars difficult. Study results support a strategy using inclusive agars (e.g. L-EMB, SHIBAM) in combination with selective agars (R & F E. coli O157:H7, CHROMagar STEC) to allow for recovery of the most STECs while increasing the probability of recovering STEC in high bacterial count matrices. JF - Food Microbiology AU - Kase, Julie A AU - Maounounen-Laasri, Anna AU - Son, Insook AU - Lin, Andrew AU - Hammack, Thomas S AD - Division of Microbiology, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, College Park, MD 20740, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 280 EP - 287 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Bacteriological agar KW - STEC KW - Fresh produce KW - Raw milk KW - Agar KW - Blood KW - Colonies KW - Milk KW - Coloration KW - Food KW - Escherichia coli KW - tellurite KW - Spinacia oleracea KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647018857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Comparison+of+eight+different+agars+for+the+recovery+of+clinically+relevant+non-O157+Shiga+toxin-producing+Escherichia+coli+from+baby+spinach%2C+cilantro%2C+alfalfa+sprouts+and+raw+milk&rft.au=Kase%2C+Julie+A%3BMaounounen-Laasri%2C+Anna%3BSon%2C+Insook%3BLin%2C+Andrew%3BHammack%2C+Thomas+S&rft.aulast=Kase&rft.aufirst=Julie&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=280&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.08.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Blood; Agar; Colonies; Coloration; Milk; Food; tellurite; Escherichia coli; Spinacia oleracea DO - http://dx.doi.org/10.1016/j.fm.2014.08.020 ER - TY - JOUR T1 - Evaluation and comparison of rapid methods for the detection of Salmonella in naturally contaminated pine nuts using different pre enrichment media AN - 1647018841; 21290767 AB - Foodborne outbreaks, involving pine nuts and peanut butter, illustrate the need to rapidly detect Salmonella in low moisture foods. However, the current Bacteriological Analytical Manual (BAM) culture method for Salmonella, using lactose broth (LB) as a pre enrichment medium, has not reliably supported real-time quantitative PCR (qPCR) assays for certain foods. We evaluated two qPCR assays in LB and four other pre enrichment media: buffered peptone water (BPW), modified BPW (mBPW), Universal Pre enrichment broth (UPB), and BAX registered MP media to detect Salmonella in naturally-contaminated pine nuts (2011 outbreak). A four-way comparison among culture method, Pathatrix registered Auto, VIDAS registered Easy SLM, and qPCR was conducted. Automated DNA extraction techniques were compared with manual extraction methods (boiling or InstaGene(TM)). There were no significant differences (P > 0.05) among the five pre enrichment media for pine nuts using the culture method. While both qPCR assays produced significantly (P less than or equal to 0.05) higher false negatives in 24 h pre enriched LB than in the other four media, they were as sensitive as the culture method in BPW, mBPW, UPB, and BAX media. The VIDAS Easy and qPCR were equivalent; Pathatrix was the least effective method. The Automatic PrepSEQ(TM) DNA extraction, using 1000 mu L of pre enrichment, was as effective as manual extraction methods. JF - Food Microbiology AU - Wang, Hua AU - Gill, Vikas S AU - Cheng, Chorng-Ming AU - Gonzalez-Escalona, Narjol AU - Irvin, Kari A AU - Zheng, Jie AU - Bell, Rebecca L AU - Jacobson, Andrew P AU - Hammack, Thomas S AD - FDA-Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 58 EP - 65 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salmonella KW - Pre enrichment media KW - qPCR KW - Pathatrix registered Auto KW - VIDAS registered Easy KW - DNA extraction KW - PrepSEQ(TM) KW - Pine nuts KW - Arachis hypogaea KW - Peanut butter KW - Lactose KW - Food KW - Media (enrichment) KW - Nuts KW - Boiling KW - Bax protein KW - peptone KW - Polymerase chain reaction KW - Media (culture) KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647018841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Evaluation+and+comparison+of+rapid+methods+for+the+detection+of+Salmonella+in+naturally+contaminated+pine+nuts+using+different+pre+enrichment+media&rft.au=Wang%2C+Hua%3BGill%2C+Vikas+S%3BCheng%2C+Chorng-Ming%3BGonzalez-Escalona%2C+Narjol%3BIrvin%2C+Kari+A%3BZheng%2C+Jie%3BBell%2C+Rebecca+L%3BJacobson%2C+Andrew+P%3BHammack%2C+Thomas+S&rft.aulast=Wang&rft.aufirst=Hua&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.06.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Lactose; Peanut butter; Boiling; peptone; Bax protein; Food; Media (enrichment); Polymerase chain reaction; Nuts; Media (culture); Arachis hypogaea; Salmonella DO - http://dx.doi.org/10.1016/j.fm.2014.06.028 ER - TY - JOUR T1 - Effect of Listeria seeligeri or Listeria welshimeri on Listeria monocytogenes detection in and recovery from buffered Listeria enrichment broth AN - 1647015028; 21290796 AB - The presence of multiple species of Listeria in regulated food products is not uncommon and can complicate the recovery of Listeria monocytogenes particularly on a non-differentiating medium. The potential complications of Listeria seeligeri and Listeria welshimeri on the recovery of L. monocytogenes from inoculated food test samples using the U.S. Food and Drug Administration's (FDA) selective enrichment procedure was investigated. Post-enrichment enumeration, in the absence of food product, indicates that some L. seeligeri and L. monocytogenes pairings may have population differentials as great as 2.7 plus or minus 0.1 logs with L. seeligeri being the predominant species. A similar observation was noted for L. welshimeri and L. monocytogenes pairings which resulted in population differentials as large as 3.7 plus or minus 0.2 logs with L. welshimeri being the predominant species. Select strain pairings were used to inoculate guacamole, crab meat, broccoli, and cheese with subsequent recovery by the FDA Bacteriological Analytical Manual (BAM) method with 10 colonies per sample selected for confirmation. The presence of L. seeligeri had little effect on the recovery of L. monocytogenes. The presence of L. welshimeri resulted in the failure to recover L. monocytogenes in three out of the four food matrices. This work extends the observation that non-pathogenic species of Listeria can complicate the recovery of L. monocytogenes and that competition during selective enrichment is not limited to the presence of just Listeria innocua. JF - Food Microbiology AU - Dailey, Rachel C AU - Welch, Lacinda J AU - Hitchins, Anthony D AU - Smiley, RDerike AD - U.S. Food and Drug Administration, Arkansas Regional Laboratory, 3900 NCTR Road, Jefferson, AR 72079, USA Y1 - 2015/04// PY - 2015 DA - April 2015 SP - 528 EP - 534 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Regulatory microbiology KW - Foodborne pathogen KW - Microbial competition KW - Real-time PCR KW - Immunofluorescence assay KW - Lateral flow device KW - Analytical microbiology KW - Selective enrichment KW - Listeria KW - Listeria seeligeri KW - Meat KW - Listeria monocytogenes KW - Colonies KW - Decapoda KW - Listeria welshimeri KW - Listeria innocua KW - Cheese KW - Brassica KW - Competition KW - J 02320:Cell Biology KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647015028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Effect+of+Listeria+seeligeri+or+Listeria+welshimeri+on+Listeria+monocytogenes+detection+in+and+recovery+from+buffered+Listeria+enrichment+broth&rft.au=Dailey%2C+Rachel+C%3BWelch%2C+Lacinda+J%3BHitchins%2C+Anthony+D%3BSmiley%2C+RDerike&rft.aulast=Dailey&rft.aufirst=Rachel&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=528&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.09.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Meat; Colonies; Cheese; Competition; Listeria seeligeri; Listeria monocytogenes; Decapoda; Listeria welshimeri; Listeria innocua; Brassica DO - http://dx.doi.org/10.1016/j.fm.2014.09.008 ER - TY - JOUR T1 - Magnetic bead based immuno-detection of Listeria monocytogenes and Listeria ivanovii from infant formula and leafy green vegetables using the Bio-Plex suspension array system AN - 1647014969; 21290797 AB - Listeriosis, a disease contracted via the consumption of foods contaminated with pathogenic Listeria species, can produce severe symptoms and high mortality in susceptible people and animals. The development of molecular methods and immuno-based techniques for detection of pathogenic Listeria in foods has been challenging due to the presence of assay inhibiting food components. In this study, we utilize a macrophage cell culture system for the isolation and enrichment of Listeria monocytogenes and Listeria ivanovii from infant formula and leafy green vegetables for subsequent identification using the Luminex xMAP technique. Macrophage monolayers were exposed to infant formula, lettuce and celery contaminated with L. monocytogenes or L. ivanovii. Magnetic microspheres conjugated to Listeria specific antibody were used to capture Listeria from infected macrophages and then analyzed using the Bio-Plex 200 analyzer. As few as 10 CFU/mL or g of L. monocytogenes was detected in all foods tested. The detection limit for L. ivanovii was 10 CFU/mL in infant formula and 100 CFU/g in leafy greens. Microsphere bound Listeria obtained from infected macrophage lysates could also be isolated on selective media for subsequent confirmatory identification. This method presumptively identifies L. monocytogenes and L. ivanovii from infant formula, lettuce and celery in less than 28 h with confirmatory identifications completed in less than 48 h. JF - Food Microbiology AU - Day, J B AU - Basavanna, U AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA PY - 2015 SP - 564 EP - 572 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Listeria KW - Detection KW - Foods KW - Macrophage KW - Bio-Plex KW - Macrophages KW - Listeria monocytogenes KW - Mortality KW - Vegetables KW - Infant formulas KW - Listeriosis KW - Food KW - Cell culture KW - Food contamination KW - Media (selective) KW - Food consumption KW - Antibodies KW - Colony-forming cells KW - Listeria ivanovii KW - microspheres KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647014969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Magnetic+bead+based+immuno-detection+of+Listeria+monocytogenes+and+Listeria+ivanovii+from+infant+formula+and+leafy+green+vegetables+using+the+Bio-Plex+suspension+array+system&rft.au=Day%2C+J+B%3BBasavanna%2C+U&rft.aulast=Day&rft.aufirst=J&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.09.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Macrophages; Mortality; Infant formulas; Vegetables; Listeriosis; Food; Cell culture; Food contamination; Media (selective); Food consumption; Antibodies; Colony-forming cells; microspheres; Listeria monocytogenes; Listeria ivanovii DO - http://dx.doi.org/10.1016/j.fm.2014.09.020 ER - TY - JOUR T1 - Cleaning and sanitation of Salmonella-contaminated peanut butter processing equipment AN - 1647014758; 21290762 AB - Microbial contamination of peanut butter by Salmonella poses a significant health risk as Salmonella may remain viable throughout the product shelf life. Effective cleaning and sanitation of processing lines are essential for preventing cross-contamination. The objective of this study was to evaluate the efficacy of a cleaning and sanitation procedure involving hot oil and 60% isopropanol, plus or minus quaternary ammonium compounds, to decontaminate pilot-scale processing equipment harboring Salmonella. Peanut butter inoculated with a cocktail of four Salmonella serovars (7 log CFU/g) was used to contaminate the equipment (75 L). The system was then emptied of peanut butter and treated with hot oil (90 degree C) for 2 h followed by sanitizer for 1 h. Microbial analysis of food-contact surfaces (7 locations), peanut butter, and oil were conducted. Oil contained 3.2 log CFU/mL on both trypticase soy agar with yeast extract (TSAYE) and xylose lysine deoxycholate (XLD), indicating hot oil alone was not sufficient to inactivate Salmonella. Environmental sampling found 0.25-1.12 log CFU/cm2 remaining on processing equipment. After the isopropanol sanitation ( plus or minus quaternary ammonium compounds), no Salmonella was detected in environmental samples on XLD (<0.16 log CFU/cm2). These data suggest that a two-step hot oil clean and isopropanol sanitization treatment may eliminate pathogenic Salmonella from contaminated equipment. JF - Food Microbiology AU - Grasso, Elizabeth M AU - Grove, Stephen F AU - Halik, Lindsay A AU - Arritt, Fletcher AU - Keller, Susanne E AD - Office of the Commissioner, U.S. Food and Drug Administration, 6502 S. Archer Road, Bedford Park, IL 60501-1957, USA Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 100 EP - 106 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Peanut butter KW - Salmonella KW - Sanitation KW - Arachis hypogaea KW - Agar KW - Ammonium KW - Data processing KW - Xylose KW - Quaternary ammonium compounds KW - Food KW - Lysine KW - Shelf life KW - Food contamination KW - Soybeans KW - Oil KW - Colony-forming cells KW - Sanitizers KW - Sampling KW - J 02420:Plant Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647014758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Cleaning+and+sanitation+of+Salmonella-contaminated+peanut+butter+processing+equipment&rft.au=Grasso%2C+Elizabeth+M%3BGrove%2C+Stephen+F%3BHalik%2C+Lindsay+A%3BArritt%2C+Fletcher%3BKeller%2C+Susanne+E&rft.aulast=Grasso&rft.aufirst=Elizabeth&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Ammonium; Agar; Peanut butter; Xylose; Data processing; Quaternary ammonium compounds; Food; Lysine; Food contamination; Shelf life; Soybeans; Oil; Sanitation; Colony-forming cells; Sanitizers; Sampling; Arachis hypogaea; Salmonella DO - http://dx.doi.org/10.1016/j.fm.2014.03.003 ER - TY - JOUR T1 - Evaluation of loop-mediated isothermal amplification for the rapid, reliable, and robust detection of Salmonella in produce AN - 1647006779; 21290812 AB - Rapid, reliable, and robust detection of Salmonella in produce remains a challenge. In this study, loop-mediated isothermal amplification (LAMP) was comprehensively evaluated against real-time quantitative PCR (qPCR) for detecting diverse Salmonella serovars in various produce items (cantaloupe, pepper, and several varieties of lettuce, sprouts, and tomato). To mimic real-world contamination events, produce samples were surface-inoculated with low concentrations (1.1-2.9 CFU/25 g) of individual Salmonella strains representing ten serovars and tested after aging at 4 degree C for 48 h. Four DNA extraction methods were also compared using produce enrichment broths. False-positive or false-negative results were not observed among 178 strains (151 Salmonella and 27 non-Salmonella) used to evaluate assay specificity. The detection limits for LAMP were 1.8-4 CFU per reaction in pure culture and 104-106 CFU per 25 g (i.e., 102-104 CFU per g) in produce without enrichment, comparable to those obtained by qPCR. After 6-8 h of enrichment, both LAMP and qPCR consistently detected these low concentrations of Salmonella of diverse serovars in all produce items except sprouts. The PrepMan Ultra sample preparation reagent yielded the best results among the four DNA extraction methods. Upon further validation, LAMP may be a valuable tool for routine Salmonella testing in produce. The difficulty of detecting Salmonella in sprouts, whether using LAMP or qPCR, warrants further study. JF - Food Microbiology AU - Yang, Qianru AU - Wang, Fei AU - Jones, Kelly L AU - Meng, Jianghong AU - Prinyawiwatkul, Witoon AU - Ge, Beilei AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, MD 20708, USA Y1 - 2015/04// PY - 2015 DA - Apr 2015 SP - 485 EP - 493 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 46 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Detection KW - LAMP KW - Produce KW - qPCR KW - Salmonella KW - Lycopersicon esculentum KW - Pure culture KW - Cucumis melo KW - Colony-forming cells KW - Aging KW - Polymerase chain reaction KW - Food contamination KW - J 02420:Plant Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647006779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Evaluation+of+loop-mediated+isothermal+amplification+for+the+rapid%2C+reliable%2C+and+robust+detection+of+Salmonella+in+produce&rft.au=Yang%2C+Qianru%3BWang%2C+Fei%3BJones%2C+Kelly+L%3BMeng%2C+Jianghong%3BPrinyawiwatkul%2C+Witoon%3BGe%2C+Beilei&rft.aulast=Yang&rft.aufirst=Qianru&rft.date=2015-04-01&rft.volume=46&rft.issue=&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.09.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Pure culture; Colony-forming cells; Aging; Polymerase chain reaction; Food contamination; Lycopersicon esculentum; Cucumis melo; Salmonella DO - http://dx.doi.org/10.1016/j.fm.2014.09.011 ER - TY - JOUR T1 - Re-annotation of presumed noncoding disease/trait-associated genetic variants by integrative analyses. AN - 1667958585; 25819875 AB - Using RefSeq annotations, most disease/trait-associated genetic variants identified by genome-wide association studies (GWAS) appear to be located within intronic or intergenic regions, which makes it difficult to interpret their functions. We reassessed GWAS-Associated single-nucleotide polymorphisms (herein termed as GASs) for their potential functionalities using integrative approaches. 8834 of 9184 RefSeq "noncoding" GASs were reassessed to have potential regulatory functionalities. As examples, 3 variants (rs3130320, rs3806932 and rs6890853) were shown to have regulatory properties in HepG2, A549 and 293T cells. Except rs3130320 as a known expression quantitative trait loci (eQTL), rs3806932 and rs6890853 were not reported as eQTLs in previous reports. 1999 of 9184 "noncoding" GASs were re-annotated to the promoters or intragenic regions using Ensembl, UCSC and AceView gene annotations but they were not annotated into corresponding regions in RefSeq database. Moreover, these GAS-harboring genes were broadly expressed across different tissues and a portion of them was expressed in a tissue-specific manner, suggesting that they could be functional. Collectively, our study demonstrates the benefits of using integrative analyses to interpret genetic variants and may help to predict or explain disease susceptibility more accurately and comprehensively. JF - Scientific reports AU - Chen, Geng AU - Yu, Dianke AU - Chen, Jiwei AU - Cao, Ruifang AU - Yang, Juan AU - Wang, Huan AU - Ji, Xiangjun AU - Ning, Baitang AU - Shi, Tieliu AD - 1] The Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, the Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China [2] Center for Pharmacogenomics, School of Pharmacy, Fudan University, Shanghai 201203, China. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; The Center for Bioinformatics and Computational Biology, Shanghai Key Laboratory of Regulatory Biology, the Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China. Y1 - 2015/03/30/ PY - 2015 DA - 2015 Mar 30 SP - 9453 VL - 5 KW - Index Medicus KW - Gene Expression Profiling KW - Promoter Regions, Genetic KW - Hep G2 Cells KW - Humans KW - Polymorphism, Single Nucleotide -- genetics KW - Molecular Sequence Annotation KW - Quantitative Trait Loci -- genetics KW - Genetic Predisposition to Disease KW - Databases, Genetic KW - Genome-Wide Association Study UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1667958585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Re-annotation+of+presumed+noncoding+disease%2Ftrait-associated+genetic+variants+by+integrative+analyses.&rft.au=Chen%2C+Geng%3BYu%2C+Dianke%3BChen%2C+Jiwei%3BCao%2C+Ruifang%3BYang%2C+Juan%3BWang%2C+Huan%3BJi%2C+Xiangjun%3BNing%2C+Baitang%3BShi%2C+Tieliu&rft.aulast=Chen&rft.aufirst=Geng&rft.date=2015-03-30&rft.volume=5&rft.issue=&rft.spage=9453&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep09453 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-25 N1 - Date created - 2015-03-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nature. 2013 Oct 17;502(7471):333-9 [24132290] Genome Res. 2012 Sep;22(9):1760-74 [22955987] Mol Psychiatry. 2014 Feb;19(2):228-34 [23319000] Nat Genet. 2014 Mar;46(3):310-5 [24487276] Nat Genet. 2011 Mar;43(3):246-52 [21297633] Cell. 2013 Mar 14;152(6):1298-307 [23498938] RNA. 2013 Apr;19(4):479-89 [23431329] Hum Mol Genet. 2013 May 15;22(10):2119-27 [23314186] Nature. 2013 May 2;497(7447):127-31 [23615609] Hum Genet. 2013 Aug;132(8):899-911 [23572138] Science. 2013 Oct 4;342(6154):1235587 [24092746] Nat Biotechnol. 2010 May;28(5):511-5 [20436464] Nature. 2010 Aug 5;466(7307):707-13 [20686565] Nucleic Acids Res. 2010 Sep;38(16):e164 [20601685] PLoS Comput Biol. 2010;6(12):e1001025 [21152010] Genet Epidemiol. 2011 Feb;35(2):125-32 [21254220] PLoS Genet. 2011 Mar;7(3):e1001323 [21408207] Nat Methods. 2011 Jun;8(6):469-77 [21623353] Genome Biol. 2011;12(2):R13 [21310039] Nature. 2011 Oct 27;478(7370):476-82 [21993624] Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 [22064851] Nucleic Acids Res. 2012 Jan;40(Database issue):D130-5 [22121212] Nucleic Acids Res. 2012 Jan;40(Database issue):D1047-54 [22139925] Nat Protoc. 2012 Mar;7(3):562-78 [22383036] Genome Res. 2012 Sep;22(9):1748-59 [22955986] Circ Cardiovasc Genet. 2009 Aug;2(4):322-8 [20031603] Hum Mol Genet. 2010 Apr 15;19(8):1479-91 [20093296] Nucleic Acids Res. 2014 Jan;42(Database issue):D1001-6 [24316577] Genome Res. 2012 Sep;22(9):1790-7 [22955989] Nature. 2012 Sep 6;489(7414):57-74 [22955616] Nature. 2012 Sep 6;489(7414):101-8 [22955620] Science. 2012 Sep 7;337(6099):1190-5 [22955828] Am J Hum Genet. 2012 Oct 5;91(4):721-8 [23000144] Nature. 2012 Nov 1;491(7422):119-24 [23128233] Nat Biotechnol. 2012 Nov;30(11):1095-106 [23138309] Nucleic Acids Res. 2013 Jan;41(Database issue):D64-9 [23155063] Nucleic Acids Res. 2013 Jan;41(Database issue):D48-55 [23203987] PLoS Genet. 2013;9(1):e1003190 [23341777] PLoS Genet. 2013;9(1):e1003201 [23341781] Nat Genet. 2013 Feb;45(2):191-6 [23263487] Nat Genet. 2013 Feb;45(2):202-7 [23291587] Biochem Biophys Res Commun. 2000 Mar 24;269(3):692-6 [10720478] Genes Dev. 2003 Feb 15;17(4):419-37 [12600935] Genome Res. 2005 Aug;15(8):1034-50 [16024819] Science. 2005 Oct 14;310(5746):317-20 [16224024] Genome Biol. 2006;7 Suppl 1:S12.1-14 [16925834] Nat Genet. 2007 Feb;39(2):212-7 [17206144] Nat Genet. 2007 May;39(5):638-44 [17401364] Nucleic Acids Res. 2008 Jun;36(10):3420-35 [18445632] Nat Genet. 2008 Nov;40(11):1307-12 [18794855] Nat Rev Genet. 2009 Mar;10(3):155-9 [19188922] Nat Genet. 2009 Mar;41(3):342-7 [19198610] Nat Rev Genet. 2009 Apr;10(4):241-51 [19293820] Bioinformatics. 2009 Jun 15;25(12):i54-62 [19478016] Genome Biol. 2009;10(3):R25 [19261174] Nat Genet. 2009 Oct;41(10):1094-9 [19734903] Nat Genet. 2010 Apr;42(4):289-91 [20208534] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep09453 ER - TY - CPAPER T1 - Systems Pharmacology for Prediction of Adverse Drug Events T2 - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AN - 1669822583; 6341272 JF - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AU - Abernethy, Darrell Y1 - 2015/03/28/ PY - 2015 DA - 2015 Mar 28 KW - Prediction KW - Pharmacology KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822583?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.atitle=Systems+Pharmacology+for+Prediction+of+Adverse+Drug+Events&rft.au=Abernethy%2C+Darrell&rft.aulast=Abernethy&rft.aufirst=Darrell&rft.date=2015-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/Annual_Meeting_EB_2015/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Multi-wall Carbon Nanotubes and Carbon Nanofibers: Toxicological Characterization in the Lungs T2 - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AN - 1669822468; 6341211 JF - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AU - Porter, Dale Y1 - 2015/03/28/ PY - 2015 DA - 2015 Mar 28 KW - Carbon KW - Lung KW - nanotubes KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.atitle=Multi-wall+Carbon+Nanotubes+and+Carbon+Nanofibers%3A+Toxicological+Characterization+in+the+Lungs&rft.au=Porter%2C+Dale&rft.aulast=Porter&rft.aufirst=Dale&rft.date=2015-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/Annual_Meeting_EB_2015/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - The Necessity of Publishing Replication and Failure to Replicate Studies: Criteria and Venues T2 - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AN - 1669822457; 6341242 JF - 2015 Annual Meeting of the American Society of Pharmacology and Experimental Therapeutics (ASPET 2015) AU - Abernethy, Darrell Y1 - 2015/03/28/ PY - 2015 DA - 2015 Mar 28 KW - Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.atitle=The+Necessity+of+Publishing+Replication+and+Failure+to+Replicate+Studies%3A+Criteria+and+Venues&rft.au=Abernethy%2C+Darrell&rft.aulast=Abernethy&rft.aufirst=Darrell&rft.date=2015-03-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+Annual+Meeting+of+the+American+Society+of+Pharmacology+and+Experimental+Therapeutics+%28ASPET+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aspet.org/Annual_Meeting_EB_2015/Program/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - New publicly available chemical query language, CSRML, to support chemotype representations for application to data mining and modeling. AN - 1666294790; 25647539 AB - Chemotypes are a new approach for representing molecules, chemical substructures and patterns, reaction rules, and reactions. Chemotypes are capable of integrating types of information beyond what is possible using current representation methods (e.g., SMARTS patterns) or reaction transformations (e.g., SMIRKS, reaction SMILES). Chemotypes are expressed in the XML-based Chemical Subgraphs and Reactions Markup Language (CSRML), and can be encoded not only with connectivity and topology but also with properties of atoms, bonds, electronic systems, or molecules. CSRML has been developed in parallel with a public set of chemotypes, i.e., the ToxPrint chemotypes, which are designed to provide excellent coverage of environmental, regulatory, and commercial-use chemical space, as well as to represent chemical patterns and properties especially relevant to various toxicity concerns. A software application, ChemoTyper has also been developed and made publicly available in order to enable chemotype searching and fingerprinting against a target structure set. The public ChemoTyper houses the ToxPrint chemotype CSRML dictionary, as well as reference implementation so that the query specifications may be adopted by other chemical structure knowledge systems. The full specifications of the XML-based CSRML standard used to express chemotypes are publicly available to facilitate and encourage the exchange of structural knowledge. JF - Journal of chemical information and modeling AU - Yang, Chihae AU - Tarkhov, Aleksey AU - Marusczyk, Jörg AU - Bienfait, Bruno AU - Gasteiger, Johann AU - Kleinoeder, Thomas AU - Magdziarz, Tomasz AU - Sacher, Oliver AU - Schwab, Christof H AU - Schwoebel, Johannes AU - Terfloth, Lothar AU - Arvidson, Kirk AU - Richard, Ann AU - Worth, Andrew AU - Rathman, James AD - †Molecular Networks GmbH, 91052 Erlangen, Germany. ; ∥US Food and Drug Administration Center for Food Safety and Applied Nutrition, Office of Food Additive Safety (FDA CFSAN OFAS), College Park, Maryland 20740, United States. ; ⊥National Center for Computational Toxicology, US Environmental Protection Agency (EPA), Research Triangle Park, North Carolina 27711, United States. ; #EC Joint Research Centre (JRC), I-21027 Ispra, Italy. ; ‡Altamira LLC, Columbus, Ohio 43235, United States. Y1 - 2015/03/23/ PY - 2015 DA - 2015 Mar 23 SP - 510 EP - 528 VL - 55 IS - 3 KW - Phosphoric Acids KW - 0 KW - phosphoric acid KW - E4GA8884NN KW - Index Medicus KW - Molecular Structure KW - Databases, Factual KW - Toxicology -- methods KW - User-Computer Interface KW - Phosphoric Acids -- chemistry KW - Structure-Activity Relationship KW - Software KW - Programming Languages KW - Data Mining KW - Chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1666294790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Care+Management+Science&rft.atitle=A+Markov+decision+model+for+determining+optimal+outpatient+scheduling&rft.au=Patrick%2C+Jonathan&rft.aulast=Patrick&rft.aufirst=Jonathan&rft.date=2012-06-01&rft.volume=15&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Health+Care+Management+Science&rft.issn=13869620&rft_id=info:doi/10.1007%2Fs10729-011-9185-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-10 N1 - Date created - 2015-03-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/ci500667v ER - TY - CPAPER T1 - Particle Characterization and Toxicological Evaluation of Pulmonary Exposure to Graphenes of Different Sizes T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822493; 6340627 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Roberts, J AU - Mercer, R AU - Sager, T AU - Kenyon, A AU - Bilgesu, S AU - Scabilloni, J AU - Seehra, M AU - Geddam, U AU - Leonard, S AU - Fix, N AU - Schwegler-Berry, D AU - Chaudhuri, I AU - Kyrlidis, A AU - Yingling, B AU - Wolfarth, M AU - Porter, D AU - Castranova, V AU - Erdely, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Lung KW - Particulates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Particle+Characterization+and+Toxicological+Evaluation+of+Pulmonary+Exposure+to+Graphenes+of+Different+Sizes&rft.au=Roberts%2C+J%3BMercer%2C+R%3BSager%2C+T%3BKenyon%2C+A%3BBilgesu%2C+S%3BScabilloni%2C+J%3BSeehra%2C+M%3BGeddam%2C+U%3BLeonard%2C+S%3BFix%2C+N%3BSchwegler-Berry%2C+D%3BChaudhuri%2C+I%3BKyrlidis%2C+A%3BYingling%2C+B%3BWolfarth%2C+M%3BPorter%2C+D%3BCastranova%2C+V%3BErdely%2C+A&rft.aulast=Roberts&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Determining the Predictive Capability of In Vitro Microphysiological Systems to Answer Critical Regulatory Questions T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822474; 6340723 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Fitzpatrick, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Prediction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Determining+the+Predictive+Capability+of+In+Vitro+Microphysiological+Systems+to+Answer+Critical+Regulatory+Questions&rft.au=Fitzpatrick%2C+S&rft.aulast=Fitzpatrick&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Genotoxic and Epigenotoxic Effects of Chemical Exposures: One Side of the Same Coin? T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822452; 6340861 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Pogribny, I Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Genotoxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Genotoxic+and+Epigenotoxic+Effects+of+Chemical+Exposures%3A+One+Side+of+the+Same+Coin%3F&rft.au=Pogribny%2C+I&rft.aulast=Pogribny&rft.aufirst=I&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Bugs to Drugs: The Microbiome in Human Health, Disease, and Therapeutics T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822419; 6340645 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Goering, P Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Drugs KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Bugs+to+Drugs%3A+The+Microbiome+in+Human+Health%2C+Disease%2C+and+Therapeutics&rft.au=Goering%2C+P&rft.aulast=Goering&rft.aufirst=P&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Experiences with Submission of Genomic Data for Human Risk Assessment T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822377; 6340811 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Leighton, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Risk assessment KW - Data processing KW - genomics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Regulatory+Experiences+with+Submission+of+Genomic+Data+for+Human+Risk+Assessment&rft.au=Leighton%2C+J&rft.aulast=Leighton&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Proinflammatory Responses and Inflammasome Activation by Sintered Indium-Tin Oxide Particles T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822323; 6340846 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Badding, M AU - Fix, N AU - Leonard, S AU - Cummings, K Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - oxides KW - Particulates KW - Inflammation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Proinflammatory+Responses+and+Inflammasome+Activation+by+Sintered+Indium-Tin+Oxide+Particles&rft.au=Badding%2C+M%3BFix%2C+N%3BLeonard%2C+S%3BCummings%2C+K&rft.aulast=Badding&rft.aufirst=M&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Application of a Probabilistic Framework to a Biologically Based Dose-Response Pregnancy Model to Evaluate Thyroidal Effects for Environmental Exposures to Perchlorate T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822291; 6340804 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Lumen, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Perchlorate KW - Dose-response effects KW - Perchloric acid KW - Environmental factors KW - Models KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Application+of+a+Probabilistic+Framework+to+a+Biologically+Based+Dose-Response+Pregnancy+Model+to+Evaluate+Thyroidal+Effects+for+Environmental+Exposures+to+Perchlorate&rft.au=Lumen%2C+A&rft.aulast=Lumen&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Quantifying "Stress" in Epidemiological Studies T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669822022; 6340616 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Miller, D Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Quantifying+%22Stress%22+in+Epidemiological+Studies&rft.au=Miller%2C+D&rft.aulast=Miller&rft.aufirst=D&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Overview of Combination Products: Introduction, Definitions, Terms, High-Level Review of New FDA GMP Rules T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821999; 6340485 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Nguyen, T Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Reviews KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821999?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Regulatory+Overview+of+Combination+Products%3A+Introduction%2C+Definitions%2C+Terms%2C+High-Level+Review+of+New+FDA+GMP+Rules&rft.au=Nguyen%2C+T&rft.aulast=Nguyen&rft.aufirst=T&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - US FDA's GRAS Notification Program: Considerations Regarding Oversight of Food Ingredient Safety T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821960; 6340785 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Mattia, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Food KW - Safety KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=US+FDA%27s+GRAS+Notification+Program%3A+Considerations+Regarding+Oversight+of+Food+Ingredient+Safety&rft.au=Mattia%2C+A&rft.aulast=Mattia&rft.aufirst=A&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Derivation of Tolerable Intake Values for Compounds with Limited Toxicity Data T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821154; 6340494 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Brown, R Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Data processing KW - Toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Derivation+of+Tolerable+Intake+Values+for+Compounds+with+Limited+Toxicity+Data&rft.au=Brown%2C+R&rft.aulast=Brown&rft.aufirst=R&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Effect of Furan on Transcriptomic and Gene- Specific DNA Methylation Changes in the Livers of Fisher 344 Rats in a Two-Year Carcinogenicity Study T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821123; 6340727 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Tryndyak, V AU - Ivanovsky, S AU - Han, T AU - Fuscoe, J AU - Beland, F AU - Pogribny, I Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Rats KW - Carcinogenicity KW - DNA methylation KW - Liver KW - Furans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Effect+of+Furan+on+Transcriptomic+and+Gene-+Specific+DNA+Methylation+Changes+in+the+Livers+of+Fisher+344+Rats+in+a+Two-Year+Carcinogenicity+Study&rft.au=Tryndyak%2C+V%3BIvanovsky%2C+S%3BHan%2C+T%3BFuscoe%2C+J%3BBeland%2C+F%3BPogribny%2C+I&rft.aulast=Tryndyak&rft.aufirst=V&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Approaches and Challenges for Cancer Immunotherapy from a Regulatory Perspective T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669821001; 6340483 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Ricci, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Immunotherapy KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Approaches+and+Challenges+for+Cancer+Immunotherapy+from+a+Regulatory+Perspective&rft.au=Ricci%2C+S&rft.aulast=Ricci&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - The Role of Toxicologists in a Federal Organization T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820968; 6340795 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Ghosh, C Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Organizations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=The+Role+of+Toxicologists+in+a+Federal+Organization&rft.au=Ghosh%2C+C&rft.aulast=Ghosh&rft.aufirst=C&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Infant Formula Regulation: Nutritional Adequacy and Ingredient Safety T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820903; 6340620 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Assar, C Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Infant formulas KW - Safety KW - Nutrition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Infant+Formula+Regulation%3A+Nutritional+Adequacy+and+Ingredient+Safety&rft.au=Assar%2C+C&rft.aulast=Assar&rft.aufirst=C&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - FDA Reviewer Perspective--Considerations for Bench, Biocompatibility, and Animal Testing of Absorbable Drug-Eluting Stents T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820825; 6340489 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Goode, J Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Drug delivery KW - Implants KW - FDA KW - biocompatibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=FDA+Reviewer+Perspective--Considerations+for+Bench%2C+Biocompatibility%2C+and+Animal+Testing+of+Absorbable+Drug-Eluting+Stents&rft.au=Goode%2C+J&rft.aulast=Goode&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Pulmonary Toxicity of Graphene Nanomaterials: An Emerging Concern in Manufacturing and Applications? T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820819; 6340624 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Roberts, J AU - Erdely, A Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Lung KW - Toxicity KW - nanotechnology KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Pulmonary+Toxicity+of+Graphene+Nanomaterials%3A+An+Emerging+Concern+in+Manufacturing+and+Applications%3F&rft.au=Roberts%2C+J%3BErdely%2C+A&rft.aulast=Roberts&rft.aufirst=J&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Perspective for Nonclinical Development and Safety Assessment of Antibody- Drug Conjugates T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820756; 6340543 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Ricci, S Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Safety KW - Drug development KW - Drug screening UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Regulatory+Perspective+for+Nonclinical+Development+and+Safety+Assessment+of+Antibody-+Drug+Conjugates&rft.au=Ricci%2C+S&rft.aulast=Ricci&rft.aufirst=S&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Thinking beyond General Toxicology Studies for Immunotherapeutics T2 - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AN - 1669820733; 6340606 JF - 54rd Annual Meeting of the Society of Toxicology (SOT 2015) AU - Helms, W Y1 - 2015/03/22/ PY - 2015 DA - 2015 Mar 22 KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.atitle=Thinking+beyond+General+Toxicology+Studies+for+Immunotherapeutics&rft.au=Helms%2C+W&rft.aulast=Helms&rft.aufirst=W&rft.date=2015-03-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=54rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2015Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Suitability of polystyrene as a functional barrier layer in coloured food contact materials AN - 1691286366; PQ0001543452 AB - Functional barriers in food contact materials (FCMs) are used to prevent or reduce migration from inner layers in multilayer structures to food. The effectiveness of functional barrier layers was investigated in coloured polystyrene (PS) bowls due to their intended condition of use with hot liquids such as soups or stew. Migration experiments were performed over a 10-day period using USFDA-recommended food simulants (10% ethanol, 50% ethanol, corn oil and Miglyol) along with several other food oils. At the end of the 10 days, solvent dyes had migrated from the PS bowls at 12, 1 and 31 000 ng cm super(-) super(2) into coconut oil, palm kernel oil and Miglyol respectively, and in coconut oil and Miglyol the colour change was visible to the human eye. Scanning electron microscope (SEM) images revealed that the functional barrier was no longer intact for the bowls exposed to coconut oil, palm kernel oil, Miglyol, 10% ethanol, 50% ethanol and goat's milk. Additional tests showed that 1-dodecanol, a lauryl alcohol derived from palm kernel oil and coconut oil, was present in the PS bowls at an average concentration of 11 mg kg super(-1). This compound is likely to have been used as a dispersing agent for the solvent dye and aided the migration of the solvent dye from the PS bowl into the food simulant. The solvent dye was not found in the 10% ethanol, 50% ethanol and goat's milk food simulants above their respective limits of detection, which is likely to be due to its insolubility in aqueous solutions. A disrupted barrier layer is of concern because if there are unregulated materials in the inner layers of the laminate, they may migrate to food, and therefore be considered unapproved food additives resulting in the food being deemed adulterated under the Federal Food Drug and Cosmetic Act. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Genualdi, Susan AU - Addo Ntim, Susana AU - Begley, Timothy AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, MD, USA Y1 - 2015/03/04/ PY - 2015 DA - 2015 Mar 04 SP - 395 EP - 402 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 3 SN - 1944-0049, 1944-0049 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Risk assessment KW - Alcohol KW - Milk KW - Solvents KW - Cosmetics KW - Migration KW - Oil KW - Food additives KW - Dyes KW - Corn KW - Drugs KW - Ethanol KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691286366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Suitability+of+polystyrene+as+a+functional+barrier+layer+in+coloured+food+contact+materials&rft.au=Genualdi%2C+Susan%3BAddo+Ntim%2C+Susana%3BBegley%2C+Timothy&rft.aulast=Genualdi&rft.aufirst=Susan&rft.date=2015-03-04&rft.volume=32&rft.issue=3&rft.spage=395&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2014.1002116 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Risk assessment; Oil; Alcohol; Food additives; Milk; Dyes; Corn; Solvents; Cosmetics; Drugs; Migration; Ethanol DO - http://dx.doi.org/10.1080/19440049.2014.1002116 ER - TY - JOUR T1 - Effect of interferents on the performance of direct-reading organic vapor monitors AN - 1664200422; PQ0001232352 AB - Direct-reading organic vapor monitors are often used to measure volatile organic compound concentrations in complex chemical gas mixtures. However, there is a paucity of data on the impact of multiple gases on monitor performance, even though it is known that monitor sensitivity may vary by chemical. This study investigated the effects of interferents on the performance of the MIRAN SapphIRe Portable Ambient Air Analyzer (SAP) and Century Portable Toxic Vapor Analyzer (TVA-1000) when sampling a specific agent of interest (cyclohexane). The TVA-1000 contained a dual detector: a photoionization detector (PID) and a flame ionization detector (FID). Three devices of each monitor were challenged with different combinations of cyclohexane and potential interferent vapors (hexane, methyl ethyl ketone, trichloroethylene, and toluene) at 21 degree C and 90% relative humidity (RH), an extreme environmental condition. Five replicates at four target concentrations were tested: 30, 150, 300, and 475 ppm. Multiple proportions of cyclohexane to interferent enabled the determination of the interferent effect on monitor performance. The monitor concentrations were compared to reference concentrations measured using NIOSH Method 1500. Three scenarios were investigated: no response factor, cyclohexane response factor, and weighted-mixed response factor applied. False negatives occurred more frequently for PID (21.1%), followed by FID (4.8%) and SAP (0.2%). Measurements from all monitors generally had a positive bias compared to the reference measurements. Some monitor measurements exceeded twice the reference concentrations: PID (36.8%), SAP (19.8%), and FID (6.3%). Evaluation of the 95% confidence intervals indicated that performance of all monitors varied by concentration. In addition, the performance of the PID and SAP varied by presence of an interfering compound, especially toluene and hexane for the PID and trichloroethylene for the SAP. Variability and bias associated with all these monitors preclude supplanting traditional sorbent-based tube methods for measuring volatile organic compounds (VOCs), especially for compliance monitoring. Implications:Industrial hygienists need to use care when using any of the three monitor detection types to measure the concentration of unknown chemical mixtures. Monitor performance is affected by the presence of interferents. Application of manufacturer recommended response factors may not adequately scale measurements to minimize monitor bias when compared to standard reference methods. Users should calibrate their monitors to a known reference method prior to use, if possible. Each of the monitors has its own limitations, which should be considered to ensure quality measurements are reported. JF - Journal of the Air & Waste Management Association AU - LeBouf, Ryan F AU - Coffey, Christopher C AD - Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2015/03/04/ PY - 2015 DA - 2015 Mar 04 SP - 261 EP - 269 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 65 IS - 3 SN - 1096-2247, 1096-2247 KW - Environment Abstracts; Pollution Abstracts KW - Sensitivity KW - Vapors KW - Gases KW - Ketones KW - Toluene KW - Compliance KW - Solvents KW - Humidity KW - Trichloroethylene KW - Environmental conditions KW - Volatile organic compounds KW - P 4000:WASTE MANAGEMENT KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664200422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Air+%26+Waste+Management+Association&rft.atitle=Effect+of+interferents+on+the+performance+of+direct-reading+organic+vapor+monitors&rft.au=LeBouf%2C+Ryan+F%3BCoffey%2C+Christopher+C&rft.aulast=LeBouf&rft.aufirst=Ryan&rft.date=2015-03-04&rft.volume=65&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Air+%26+Waste+Management+Association&rft.issn=10962247&rft_id=info:doi/10.1080%2F10962247.2014.986308 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Sensitivity; Vapors; Ketones; Gases; Toluene; Compliance; Solvents; Humidity; Trichloroethylene; Environmental conditions; Volatile organic compounds DO - http://dx.doi.org/10.1080/10962247.2014.986308 ER - TY - CPAPER T1 - Drug Interactions: An Evolution in Drug Development T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822479; 6340398 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Huang, Shiew-Mei Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Drug interaction KW - Drug development KW - Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822479?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Drug+Interactions%3A+An+Evolution+in+Drug+Development&rft.au=Huang%2C+Shiew-Mei&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Effects of Aging Pathophysiology on Drug Disposition and Effect T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822385; 6340401 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Abernethy, Darrell Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Aging KW - Disposition KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Effects+of+Aging+Pathophysiology+on+Drug+Disposition+and+Effect&rft.au=Abernethy%2C+Darrell&rft.aulast=Abernethy&rft.aufirst=Darrell&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Breakthrough Therapy Designation Driving Medical Innovation T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822242; 6340327 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Zineh, Issam Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Therapy KW - Innovations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Breakthrough+Therapy+Designation+Driving+Medical+Innovation&rft.au=Zineh%2C+Issam&rft.aulast=Zineh&rft.aufirst=Issam&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Perspectives on TQT Studies and Alternative Approaches to Assess TdP Risk T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822217; 6340357 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Stockbridge, Norman Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Risk assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Regulatory+Perspectives+on+TQT+Studies+and+Alternative+Approaches+to+Assess+TdP+Risk&rft.au=Stockbridge%2C+Norman&rft.aulast=Stockbridge&rft.aufirst=Norman&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Bioequivalence Standards for Narrow Therapeutic Index (NTI) Drugs: Are They Stringent Enough to Ensure Safety and Efficacy? T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822161; 6340336 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Fang, Lanyan Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Safety KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Bioequivalence+Standards+for+Narrow+Therapeutic+Index+%28NTI%29+Drugs%3A+Are+They+Stringent+Enough+to+Ensure+Safety+and+Efficacy%3F&rft.au=Fang%2C+Lanyan&rft.aulast=Fang&rft.aufirst=Lanyan&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Role of Clinical Pharmacology in Developing Evidence of Efectiveness T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669822064; 6340296 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Sinha, Vikram Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669822064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Role+of+Clinical+Pharmacology+in+Developing+Evidence+of+Efectiveness&rft.au=Sinha%2C+Vikram&rft.aulast=Sinha&rft.aufirst=Vikram&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Where Are We Headed with Evidence of Efectiveness: A Regulatory Perspective T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821892; 6340297 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Temple, Robert Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Where+Are+We+Headed+with+Evidence+of+Efectiveness%3A+A+Regulatory+Perspective&rft.au=Temple%2C+Robert&rft.aulast=Temple&rft.aufirst=Robert&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Predictive Performance of Physiologically Based Pharmacokinetc (PBPK) Models for the Effect of CYP 3A Inducers on Substrate Drugs: Analysis of Submissions to the FDA. T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821881; 6340368 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Wagner, Christian Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Prediction KW - Physiology KW - FDA KW - Drugs KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Predictive+Performance+of+Physiologically+Based+Pharmacokinetc+%28PBPK%29+Models+for+the+Effect+of+CYP+3A+Inducers+on+Substrate+Drugs%3A+Analysis+of+Submissions+to+the+FDA.&rft.au=Wagner%2C+Christian&rft.aulast=Wagner&rft.aufirst=Christian&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Efective Oral Presentations T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821860; 6340299 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Uhl, Kathleen Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Efective+Oral+Presentations&rft.au=Uhl%2C+Kathleen&rft.aulast=Uhl&rft.aufirst=Kathleen&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Regulatory Experience on Approval of ADCs T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821142; 6340360 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Schrieber, Sarah Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Regulatory+Experience+on+Approval+of+ADCs&rft.au=Schrieber%2C+Sarah&rft.aulast=Schrieber&rft.aufirst=Sarah&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Impact of Altered in Vitro Dissolution Profile on Warfarin in Vivo Pharmacokinetics Performance- Population Physiologically Based Pharmacokinetic (PBPK) Simulation. T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821108; 6340439 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Fan, J AU - Zhang, X AU - Lionberger, R Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Physiology KW - Dissolution KW - Simulation KW - Warfarin KW - Ecosystem disturbance KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Impact+of+Altered+in+Vitro+Dissolution+Profile+on+Warfarin+in+Vivo+Pharmacokinetics+Performance-+Population+Physiologically+Based+Pharmacokinetic+%28PBPK%29+Simulation.&rft.au=Fan%2C+J%3BZhang%2C+X%3BLionberger%2C+R&rft.aulast=Fan&rft.aufirst=J&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Pediatric Clinical Pharmacology T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821038; 6340402 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Green, Dionna Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pediatrics KW - Pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Pediatric+Clinical+Pharmacology&rft.au=Green%2C+Dionna&rft.aulast=Green&rft.aufirst=Dionna&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Biomarkers and Pharmacometrics in Drug Development: A Regulatory Perspective T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821025; 6340342 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Marathe, Dhananjay Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Bioindicators KW - Drug development KW - Biomarkers KW - biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Biomarkers+and+Pharmacometrics+in+Drug+Development%3A+A+Regulatory+Perspective&rft.au=Marathe%2C+Dhananjay&rft.aulast=Marathe&rft.aufirst=Dhananjay&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - What are the Regulatory Expectations for Dose Selection of Biologics T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669821013; 6340322 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Zhao, Hong Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Pharmacology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669821013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=What+are+the+Regulatory+Expectations+for+Dose+Selection+of+Biologics&rft.au=Zhao%2C+Hong&rft.aulast=Zhao&rft.aufirst=Hong&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Exposure Response Analysis as Evidence for Approval of Canagliflozin-Metformin Immediate Release Fixed-Dose Combination Product: A Regulatory Perspective. T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820969; 6340337 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Marathe, Anshu Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Response analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Exposure+Response+Analysis+as+Evidence+for+Approval+of+Canagliflozin-Metformin+Immediate+Release+Fixed-Dose+Combination+Product%3A+A+Regulatory+Perspective.&rft.au=Marathe%2C+Anshu&rft.aulast=Marathe&rft.aufirst=Anshu&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Pro Endpoints in Oncology Trials: A Regulatory Perspective T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820830; 6340388 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Slagle, Ashley Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Pro+Endpoints+in+Oncology+Trials%3A+A+Regulatory+Perspective&rft.au=Slagle%2C+Ashley&rft.aulast=Slagle&rft.aufirst=Ashley&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Milestones: Sex-Related Insights from Post-Marketing Data T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820810; 6340350 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Kim, Myong-Jin Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Data processing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Milestones%3A+Sex-Related+Insights+from+Post-Marketing+Data&rft.au=Kim%2C+Myong-Jin&rft.aulast=Kim&rft.aufirst=Myong-Jin&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Pharmacogenetics and Racial Composition in Clinical Trials for Non-Small Cell Lung Cancer and Chronic Hepatitis C Infection. T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820805; 6340308 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Ramamoorthy, A AU - Bull, J AU - Zhang, L AU - Pacanowski, M Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Chronic infection KW - Non-small cell lung carcinoma KW - Hepatitis C KW - Infection KW - Clinical trials KW - Pharmacogenetics KW - Lung cancer KW - Hepatitis C virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Pharmacogenetics+and+Racial+Composition+in+Clinical+Trials+for+Non-Small+Cell+Lung+Cancer+and+Chronic+Hepatitis+C+Infection.&rft.au=Ramamoorthy%2C+A%3BBull%2C+J%3BZhang%2C+L%3BPacanowski%2C+M&rft.aulast=Ramamoorthy&rft.aufirst=A&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - When Should In Vivo Transporter- Mediated Drug-Drug Interaction Studies be Conducted? A Regulatory Perspective T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820695; 6340366 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Zhang, Lei Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Drug interaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=When+Should+In+Vivo+Transporter-+Mediated+Drug-Drug+Interaction+Studies+be+Conducted%3F+A+Regulatory+Perspective&rft.au=Zhang%2C+Lei&rft.aulast=Zhang&rft.aufirst=Lei&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Physiologically-Based Pharmacokinetic Modeling(PBPK) of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIS) T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820673; 6340315 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Duan, P AU - Zhao, P AU - Zhang, L Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Drug interaction KW - Atorvastatin KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Physiologically-Based+Pharmacokinetic+Modeling%28PBPK%29+of+Pitavastatin+and+Atorvastatin+to+Predict+Drug-Drug+Interactions+%28DDIS%29&rft.au=Duan%2C+P%3BZhao%2C+P%3BZhang%2C+L&rft.aulast=Duan&rft.aufirst=P&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - CPAPER T1 - Little Data, Big Decisions in Regulatory Review T2 - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AN - 1669820609; 6340324 JF - 2015 American Society for Clinical Pharmacology and Therapeutics (ASCPT 2015) AU - Krudys, Kevin Y1 - 2015/03/03/ PY - 2015 DA - 2015 Mar 03 KW - Data processing KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1669820609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.atitle=Little+Data%2C+Big+Decisions+in+Regulatory+Review&rft.au=Krudys%2C+Kevin&rft.aulast=Krudys&rft.aufirst=Kevin&rft.date=2015-03-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2015+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2015%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2015%20Annual%20Meeting/Final%20Program%20-%20FINAL.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-31 N1 - Last updated - 2015-04-06 ER - TY - JOUR T1 - Low-frequency KRAS mutations are prevalent in lung adenocarcinomas AN - 1842508030; PQ0001435717 AB - Aim: This study quantified low-frequency KRAS mutations in normal lung and lung adenocarcinomas, to understand their potential significance in the development of acquired resistance to EGFR-targeted therapies. Materials & methods: Allele-specific Competitive Blocker-PCR was used to quantify KRAS codon 12 GAT (G12D) and GTT (G12V) mutation in 19 normal lung and 21 lung adenocarcinoma samples. Results: Lung adenocarcinomas had KRAS codon 12 GAT and GTT geometric mean mutant fractions of 1.94 10 super(-4) and 1.16 10 super(-3), respectively. For 76.2% of lung adenocarcinomas, the level of KRAS mutation was greater than the upper 95% confidence interval of that in normal lung. Conclusion: KRAS mutant tumor subpopulations, not detectable by DNA sequencing, may drive resistance to EGFR blockade in lung adenocarcinoma patients. JF - Personalized Medicine AU - Myers, Meagan B AU - McKim, Karen L AU - Meng, Fanxue AU - Parsons, Barbara L AD - super(1)Division of Genetic & Molecular Toxicology, US FDA, National Center for Toxicological Research, Jefferson, AR 72079, USA Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 83 EP - 98 PB - Future Science Group (FSG), Unitec House, 2 Albert Place London N3 1QB United Kingdom VL - 12 IS - 2 SN - 1741-0541, 1741-0541 KW - Toxicology Abstracts KW - carcinogenesis KW - epidermal growth factor receptor KW - mutation KW - mutation detection KW - non-small-cell lung cancer KW - oncogene KW - oncogene-induced senescence KW - personalized medicine KW - polyclonal tumor origin KW - targeted molecular therapy KW - K-Ras protein KW - DNA sequencing KW - Lung KW - Subpopulations KW - Codons KW - Epidermal growth factor receptors KW - Tumors KW - Adenocarcinoma KW - Mutation KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1842508030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personalized+Medicine&rft.atitle=Low-frequency+KRAS+mutations+are+prevalent+in+lung+adenocarcinomas&rft.au=Myers%2C+Meagan+B%3BMcKim%2C+Karen+L%3BMeng%2C+Fanxue%3BParsons%2C+Barbara+L&rft.aulast=Myers&rft.aufirst=Meagan&rft.date=2015-03-01&rft.volume=12&rft.issue=2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Personalized+Medicine&rft.issn=17410541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Number of references - 64 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - K-Ras protein; DNA sequencing; Lung; Subpopulations; Codons; Epidermal growth factor receptors; Tumors; Adenocarcinoma; Mutation ER - TY - JOUR T1 - Biomarkers of brevetoxin exposure and composite toxin levels in hard clam (Mercenaria sp.) exposed to Karenia brevis blooms AN - 1701495140; PQ0001683095 AB - Brevetoxins in clams (Mercenaria sp.) exposed to recurring blooms of Karenia brevis in Sarasota Bay, FL, were studied over a three-year period. Brevetoxin profiles in toxic clams were generated by ELISA and LC-MS. Several brevetoxin metabolites, as identified by LC-MS, were major contributors to the composite brevetoxin response of ELISA. These were S-desoxyBTX-B2 (m/z 1018), BTX-B2 (m/z 1034), BTX-B5 (m/z 911), open A-ring BTX-B5 (m/z 929), and BTX-B1 (m/z 1018). Summed values of these metabolites were highly correlated (R2 = 0.9) with composite B-type brevetoxin measurements by ELISA. S-desoxyBTX-B2, BTX-B2, and BTX-B1 were the most persistent and detectable in shellfish for several months after dissipation of blooms. These metabolites were selected as LC-MS biomarkers of brevetoxin exposure and reflective of composite B-type brevetoxins in hard clam. ELISA and LC-MS values were moderately correlated with toxicity of the shellfish by mouse bioassay. ELISA and LC-MS methods offer rapid screening and confirmatory determination of brevetoxins, respectively, as well as toxicity assessment in clams exposed to K. brevis blooms. JF - Toxicon AU - Abraham, Ann AU - El Said, Kathleen R AU - Wang, Yuesong AU - Jester, Edward LE AU - Plakas, Steven M AU - Flewelling, Leanne J AU - Henry, Michael S AU - Pierce, Richard H AD - FDA, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, AL 36528, USA PY - 2015 SP - 82 EP - 88 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 96 SN - 0041-0101, 0041-0101 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Toxicology Abstracts KW - Karenia brevis KW - Brevetoxins KW - Hard clams KW - Biomarkers KW - Enzyme-linked immunosorbent assay KW - Mercenaria KW - Metabolites KW - Toxicity KW - biomarkers KW - Toxins KW - K 03410:Animal Diseases KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701495140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Biomarkers+of+brevetoxin+exposure+and+composite+toxin+levels+in+hard+clam+%28Mercenaria+sp.%29+exposed+to+Karenia+brevis+blooms&rft.au=Abraham%2C+Ann%3BEl+Said%2C+Kathleen+R%3BWang%2C+Yuesong%3BJester%2C+Edward+LE%3BPlakas%2C+Steven+M%3BFlewelling%2C+Leanne+J%3BHenry%2C+Michael+S%3BPierce%2C+Richard+H&rft.aulast=Abraham&rft.aufirst=Ann&rft.date=2015-03-01&rft.volume=96&rft.issue=&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2015.01.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; Brevetoxins; Metabolites; Toxicity; biomarkers; Toxins; Mercenaria; Karenia brevis DO - http://dx.doi.org/10.1016/j.toxicon.2015.01.014 ER - TY - JOUR T1 - School and Work Status, Drug-Free Workplace Protections, and Prescription Drug Misuse Among Americans Ages 15-25 AN - 1683501437 AB - We assessed the prevalence and characteristics of prescription drug misuse among youth ages 15-25 to examine differences by student and employment status, and associations with workplace antidrug policies and programs. Multivariate logistic regressions analyzed associations in weighted data on the 20,457 young adults in the combined 2004-2008 National Surveys on Drug Use and Health. Protective effects of drug-free workplace policy and EAPs persist after other substance use was controlled for. Comparing the effects of workplace programs on illicit drug use and problem drinking versus prescription misuse suggests that those protective associations do not result from selection bias. Thus, drug-free workplace policies and EAPs appear to help protect younger workers against prescription misuse. If workplace substance use disorder programs focused prevention messages and interventions on prescription drug misuse, their impact on misuse might increase. JF - Journal of Studies on Alcohol and Drugs AU - NOVAK, SCOTT P AU - GALVIN, DEBORAH M AU - SPICER, REBECCA S AU - CLUFF, LAURIE AU - KASAT, SANDEEP AD - RTI International, Research Triangle Park, North Carolina ; Substance Abuse and Mental Health Services Administration, Rockville, Maryland ; Pacific Institute for Research and Evaluation, Calverton, Maryland ; MILLER, TED; Pacific Institute for Research and Evaluation, 11720 Beltsville Drive, Suite 900, Calverton, MD 20705; Centre for Population Health Research, Curtin University, Perth WA 6845 Australia Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 195 EP - 203 CY - Piscataway PB - Alcohol Research Documentation, Inc. VL - 76 IS - 2 SN - 1937-1888 KW - Medical Sciences KW - Substance Abuse KW - Associations KW - Problem drinking KW - Selection bias KW - Substance abuse KW - Work status KW - Workplaces KW - Young adults KW - Young people KW - Social Programs KW - Bias KW - Workers KW - Prevention KW - Social Policy KW - Drug Abuse KW - Employment KW - Health KW - American people KW - Drug abuse KW - Employment status KW - Interventions KW - National surveys KW - Occupational status KW - Organizational policy KW - Preventive programmes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683501437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=School+and+Work+Status%2C+Drug-Free+Workplace+Protections%2C+and+Prescription+Drug+Misuse+Among+Americans+Ages+15-25&rft.au=MILLER%2C+TED%3BNOVAK%2C+SCOTT+P%3BGALVIN%2C+DEBORAH+M%3BSPICER%2C+REBECCA+S%3BCLUFF%2C+LAURIE%3BKASAT%2C+SANDEEP&rft.aulast=MILLER&rft.aufirst=TED&rft.date=2015-03-01&rft.volume=76&rft.issue=2&rft.spage=195&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-04-28 N1 - Last updated - 2016-05-13 ER - TY - JOUR T1 - Legal Challenges to the International Deployment of Government Public Health and Medical Personnel during Public Health Emergencies: Impact on National and Global Health Security AN - 1680442599; PQ0001392637 AB - International deployment of government public health and medical personnel is often necessary to respond to emergencies and enhance global health security. However, there are unique legal challenges for donors and recipient countries. Here, we summarize some of those challenges and existing international fora that may help to identify solutions. JF - Journal of Law, Medicine & Ethics AU - Davidson, Brent AU - Sherman, Susan AU - Barraza, Leila AU - Marinissen, Maria Julia AD - Acting Chief of the International Assistance & Response Policy Branch, Division of International Health Security, Office of Policy and Planning, Office of the Assistant Secretary for Preparedness and Response, at the U.S. Department of Health and Human Services. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 103 EP - 106 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 43 IS - s1 SN - 1073-1105, 1073-1105 KW - Health & Safety Science Abstracts KW - Security KW - Ethics KW - Medical personnel KW - Public health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680442599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=Legal+Challenges+to+the+International+Deployment+of+Government+Public+Health+and+Medical+Personnel+during+Public+Health+Emergencies%3A+Impact+on+National+and+Global+Health+Security&rft.au=Davidson%2C+Brent%3BSherman%2C+Susan%3BBarraza%2C+Leila%3BMarinissen%2C+Maria+Julia&rft.aulast=Davidson&rft.aufirst=Brent&rft.date=2015-03-01&rft.volume=43&rft.issue=s1&rft.spage=103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1111%2Fjlme.12229 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Security; Ethics; Medical personnel; Public health DO - http://dx.doi.org/10.1111/jlme.12229 ER - TY - JOUR T1 - Community Experiments in Public Health Law and Policy AN - 1680442207; PQ0001392624 AB - Community-level legal and policy innovations or "experiments" can be important levers to improve health. States and localities are empowered through the 10th Amendment of the United States Constitution to use their police powers to protect the health and welfare of the public. This article describes innovative approaches to public health law and policy from Minneapolis and New Orleans, communities who have been honored by the Robert Wood Johnson Foundation (RWJF) for addressing health by focusing not solely on health care access and quality, but the wider environment, including transforming neighborhoods, schools, and businesses and addressing inequities. Specifically, this article discusses examples of how these cities have used public health legal and policy approaches and novel partnerships to promote healthy eating and active living, reduce exposure to secondhand smoke, and prevent violence. JF - Journal of Law, Medicine & Ethics AU - McGowan, Angela K AU - Musicant, Gretchen G AU - Williams, Sharonda R AU - Niehaus, Virginia R AD - Organized this session as a result of her position as a Senior Program Officer with the Robert Wood Johnson Foundation. She is now a Program Director and Centers for Disease Control and Prevention assignee to the Office of Disease Prevention and Health Promotion at the U.S. Department of Health and Human Services. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 10 EP - 14 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 43 IS - s1 SN - 1073-1105, 1073-1105 KW - Health & Safety Science Abstracts KW - USA, Minnesota, Minneapolis KW - USA, Louisiana, New Orleans KW - Violence KW - Public health KW - Cities KW - USA KW - Passive smoking KW - Schools KW - Health care KW - Ethics KW - Police KW - Innovations KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680442207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Law%2C+Medicine+%26+Ethics&rft.atitle=Community+Experiments+in+Public+Health+Law+and+Policy&rft.au=McGowan%2C+Angela+K%3BMusicant%2C+Gretchen+G%3BWilliams%2C+Sharonda+R%3BNiehaus%2C+Virginia+R&rft.aulast=McGowan&rft.aufirst=Angela&rft.date=2015-03-01&rft.volume=43&rft.issue=s1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+Law%2C+Medicine+%26+Ethics&rft.issn=10731105&rft_id=info:doi/10.1111%2Fjlme.12206 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Cities; Schools; Passive smoking; Health care; Ethics; Police; Violence; Innovations; Public health; USA, Minnesota, Minneapolis; USA; USA, Louisiana, New Orleans DO - http://dx.doi.org/10.1111/jlme.12206 ER - TY - JOUR T1 - Unstable Sitting in the Workplace—Are There Physical Activity Benefits? AN - 1679030076 AB - The increasingly popular practice of using a stability ball (exercise/fitness ball) as a sitting surface runs counter to conventional human factors/ʼergonomics guidelines for seated workspace design. Employees sitting on stability balls in an office environment present safely risks that might be justifiable if the practice has a definitive benefit to the promotion of health. However, the published studies and best evidence to date call into question even, the theoretical basis for this practice and. do not suggest, significant health benefits. First, biomechanical studies do not confirm the intended trunk muscle activation. Second, energy expenditure studies show a small (if any) increase in metabolic demand that is unlikely to be effective in combating sedentary work risk factors. Until studies demonstrate more conclusive benefits, the practice of stability ball sitting should, be vieioed skeptically as a general, workplace recommendation in the interest of health or wellness. JF - American Journal of Health Promotion : AJHP. AU - Swanson, Naomi G AU - Hudock, Stephen D AU - Lotz, W Gregory AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio ; Lowe, Brian D; Division of Applied Research and Technolog, National Institute for Occupational Safety and Health, 1090 Tusculum Ave., MS C-24, Cincinnati, OH 45226 Y1 - 2015///Mar/Apr PY - 2015 DA - Mar/Apr 2015 SP - 207 EP - 209 CY - Birmingham PB - Mosby-Year Book, Inc. VL - 29 IS - 4 SN - 0890-1171 KW - Physical Fitness And Hygiene KW - Balls KW - Biomechanics KW - Sedentary KW - Workplaces KW - Energy expenditure KW - Exercise KW - Expenditure KW - Fitness KW - Health promotion KW - Human factors KW - Physical activity KW - Promotion KW - Risk factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1679030076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion+%3A+AJHP.&rft.atitle=Unstable+Sitting+in+the+Workplace%E2%80%94Are+There+Physical+Activity+Benefits%3F&rft.au=Lowe%2C+Brian+D%3BSwanson%2C+Naomi+G%3BHudock%2C+Stephen+D%3BLotz%2C+W+Gregory&rft.aulast=Lowe&rft.aufirst=Brian&rft.date=2015-03-01&rft.volume=29&rft.issue=4&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion+%3A+AJHP.&rft.issn=08901171&rft_id=info:doi/10.4278%2Fajhp.140331-CIT-127 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-05-05 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.4278/ajhp.140331-CIT-127 ER - TY - JOUR T1 - Comparative effectiveness of high-dose versus standard-dose influenza vaccines in US residents aged 65 years and older from 2012 to 2013 using Medicare data: a retrospective cohort analysis AN - 1668267461; PQ0001205015 AB - Background A high-dose trivalent inactivated influenza vaccine was licensed in 2009 by the US Food and Drug Administration (FDA) on the basis of serological criteria. We sought to establish whether high-dose inactivated influenza vaccine was more effective for prevention of influenza-related visits and hospital admissions in US Medicare beneficiaries than was standard-dose inactivated influenza vaccine. Methods In this retrospective cohort study, we identified Medicare beneficiaries aged 65 years and older who received high-dose or standard-dose inactivated influenza vaccines from community pharmacies that offered both vaccines during the 2012-13 influenza season. Outcomes were defined with billing codes on Medicare claims. The primary outcome was probable influenza infection, defined by receipt of a rapid influenza test followed by dispensing of the neuraminidase inhibitor oseltamivir. The secondary outcome was a hospital or emergency department visit, listing a Medicare billing code for influenza. We estimated relative vaccine effectiveness by comparing outcome rates in Medicare beneficiaries during periods of high influenza circulation. Univariate and multivariate Poisson regression models were used for analyses. Findings Between Aug 1, 2012 and Jan 31, 2013, we studied 929730 recipients of high-dose vaccine and 1615545 recipients of standard-dose vaccine. Participants enrolled in each cohort were well balanced with respect to age and presence of underlying medical disorders. The high-dose vaccine (1.30 outcomes per 10000 person-weeks) was 22% (95% CI 15-29) more effective than the standard-dose vaccine (1.01 outcomes per 10000 person-weeks) for prevention of probable influenza infections (rapid influenza test followed by oseltamivir treatment) and 22% (95% CI 16-27%) more effective for prevention of influenza hospital admissions (0.86 outcomes per 10000 person-weeks in the high-dose cohort vs 1.10 outcomes per 10000 person-weeks in the standard-dose cohort). Interpretation Our retrospective cohort study in US Medicare beneficiaries shows that, in people 65 years of age and older, high-dose inactivated influenza vaccine was significantly more effective than standard-dose vaccine in prevention of influenza-related medical encounters. Additionally, the large population in our study enabled us to show, for the first time, a significant reduction in influenza-related hospital admissions in high-dose compared to standard-dose vaccine recipients, an outcome not shown in randomised studies. These results provide important new information to be considered by policy makers recommending influenza vaccinations for elderly people. Funding FDA and the office of the Assistant Secretary of Planning and Evaluation. JF - Lancet Infectious Diseases AU - Izurieta, Hector S AU - Thadani, Nicole AU - Shay, David K AU - Lu, Yun AU - Maurer, Aaron AU - Foppa, Ivo M AU - Franks, Riley AU - Pratt, Douglas AU - Forshee, Richard A AU - MaCurdy, Thomas AU - Worrall, Chris AU - Howery, Andrew E AU - Kelman, Jeffrey AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 293 EP - 300 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 15 IS - 3 SN - 1473-3099, 1473-3099 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Age KW - Elderly KW - Infection KW - Models KW - Influenza KW - Infectious diseases KW - Regression analysis KW - Geriatrics KW - Exo- alpha -sialidase KW - Drugs KW - Data processing KW - Population studies KW - Vaccination KW - Oseltamivir KW - Prevention KW - FDA KW - Vaccines KW - Emergency medical services KW - Hospitals KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668267461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+Infectious+Diseases&rft.atitle=Comparative+effectiveness+of+high-dose+versus+standard-dose+influenza+vaccines+in+US+residents+aged+65+years+and+older+from+2012+to+2013+using+Medicare+data%3A+a+retrospective+cohort+analysis&rft.au=Izurieta%2C+Hector+S%3BThadani%2C+Nicole%3BShay%2C+David+K%3BLu%2C+Yun%3BMaurer%2C+Aaron%3BFoppa%2C+Ivo+M%3BFranks%2C+Riley%3BPratt%2C+Douglas%3BForshee%2C+Richard+A%3BMaCurdy%2C+Thomas%3BWorrall%2C+Chris%3BHowery%2C+Andrew+E%3BKelman%2C+Jeffrey&rft.aulast=Izurieta&rft.aufirst=Hector&rft.date=2015-03-01&rft.volume=15&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Lancet+Infectious+Diseases&rft.issn=14733099&rft_id=info:doi/10.1016%2FS1473-3099%2814%2971087-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 28 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Age; Data processing; Population studies; Infection; Vaccination; Oseltamivir; Models; Influenza; Geriatrics; Regression analysis; Vaccines; Exo- alpha -sialidase; Hospitals; Prevention; Infectious diseases; Elderly; FDA; Drugs; Emergency medical services DO - http://dx.doi.org/10.1016/S1473-3099(14)71087-4 ER - TY - JOUR T1 - Randomized single-blinded non-inferiority trial of 7 mg/kg pentamidine isethionate versus 4 mg/kg pentamidine isethionate for cutaneous leishmaniaisis in Suriname. AN - 1666294831; 25793773 AB - Standard treatment of cutaneous leishmaniasis (CL) in Suriname entails three injections of pentamidine isethionate (PI) 4 mg/kg per injection in 7 days (7 day regimen). Compliance to treatment is low and may contribute to increasing therapy failure. A 3 day regimen, including 2 injections of 7 mg/kg in 3 days may increase compliance. In a randomized, single-blinded non-inferiority trial conducted in Suriname, 84 CL patients received the 7 day regimen and 79 CL patients received the 3 day regimen. Primary objective was the proportion of patients clinically cured at 6 weeks follow-up. Secondary objectives were clinical cure at 12 weeks follow-up; parasitological cure at 6 and 12 weeks; adverse and drug related toxicity events recorded one week after the end of treatment and health related quality of life. The non-inferiority margin was set at 15%, 1 sided test, α = 0.1. At 6 weeks follow-up 31 (39%) patients in the 3 day regimen and 41 (49%) patients in the 7 day regimen were clinically cured. Intention to treat (ITT) analyses showed that the difference in proportion clinically cured was -9.6% (90% Confidence Interval (CI): -22.3% to 3.2%). Per protocol (PP) analysis showed that the difference in proportion clinically cured was 0.2% (90% CI: -14.6% to 15.2%). ITT analysis showed that the difference in proportion parasitological cured at 6 weeks was -15.2% (90% CI:-28.0% to -2.5%). PP analyses showed similar results. Non-inferiority could not be concluded for all adverse and toxicological events. We cannot conclude that the 3 day regimen is non-inferior to the 7 day regimen regarding proportion clinically and parasitological cured. Therefore there is no evidence to change the current standard practice of the 7 day regimen for the treatment of CL in Suriname. JF - PLoS neglected tropical diseases AU - Hu, Ricardo V P F AU - Straetemans, Masja AU - Kent, Alida D AU - Sabajo, Leslie O A AU - de Vries, Henry J C AU - Fat, Rudy F M Lai A AD - Dermatology Service, Ministry of Health, Paramaribo, Suriname. ; Department of Biomedical Research, Royal Tropical Institute, KIT, Amsterdam, The Netherlands. ; Department of Parasitology, Anton de Kom University of Suriname, Paramaribo, Suriname. ; Centre for Infections and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; STI Outpatient Clinic, Cluster Infectious Diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands. ; Department of Dermatology, Academic Hospital, Paramaribo, Suriname. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 1 VL - 9 IS - 3 KW - Pentamidine KW - 673LC5J4LQ KW - Index Medicus KW - Young Adult KW - Patient Compliance KW - Dose-Response Relationship, Drug KW - Humans KW - Intention to Treat Analysis KW - Adult KW - Treatment Outcome KW - Quality of Life KW - Aged KW - Suriname KW - Middle Aged KW - Time Factors KW - Male KW - Female KW - Leishmaniasis, Cutaneous -- drug therapy KW - Pentamidine -- administration & dosage KW - Pentamidine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1666294831?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+neglected+tropical+diseases&rft.atitle=Randomized+single-blinded+non-inferiority+trial+of+7+mg%2Fkg+pentamidine+isethionate+versus+4+mg%2Fkg+pentamidine+isethionate+for+cutaneous+leishmaniaisis+in+Suriname.&rft.au=Hu%2C+Ricardo+V+P+F%3BStraetemans%2C+Masja%3BKent%2C+Alida+D%3BSabajo%2C+Leslie+O+A%3Bde+Vries%2C+Henry+J+C%3BFat%2C+Rudy+F+M+Lai+A&rft.aulast=Hu&rft.aufirst=Ricardo+V+P&rft.date=2015-03-01&rft.volume=9&rft.issue=3&rft.spage=e0003592&rft.isbn=&rft.btitle=&rft.title=PLoS+neglected+tropical+diseases&rft.issn=1935-2735&rft_id=info:doi/10.1371%2Fjournal.pntd.0003592 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-03-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Dermatol. 2002 Nov;41(11):796-800 [12453009] Ann Trop Med Parasitol. 2006 Jun;100(4):307-14 [16762111] J Clin Microbiol. 1990 Mar;28(3):495-503 [1691208] Health Policy. 1990 Dec;16(3):199-208 [10109801] Clin Microbiol Rev. 2006 Jan;19(1):111-26 [16418526] J Invest Dermatol. 1996 Nov;107(5):707-13 [8875954] Trans R Soc Trop Med Hyg. 2013 May;107(5):335-6 [23474473] JAMA. 2006 Mar 8;295(10):1147-51 [16522835] J Hepatol. 2007 May;46(5):947-54 [17412447] Emerg Infect Dis. 2008 May;14(5):857-9 [18439386] PLoS Negl Trop Dis. 2008;2(10):e259 [18958168] Int J Dermatol. 2009 Jan;48(1):52-8 [19126051] Am J Trop Med Hyg. 2010 Apr;82(4):588-90 [20348504] Am J Trop Med Hyg. 2011 Feb;84(2):255-60 [21292895] J Invest Dermatol. 2011 Sep;131(9):1945-7 [21593773] J Infect Dis. 2012 Feb 15;205(4):684-92 [22238470] Am J Trop Med Hyg. 2012 May;86(5):825-7 [22556081] Soc Sci Med. 2012 Sep;75(6):1097-105 [22704264] Int J Dermatol. 2002 Jan;41(1):32-7 [11895511] Diagn Microbiol Infect Dis. 2003 Jun;46(2):115-24 [12812715] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pntd.0003592 ER - TY - JOUR T1 - Quantification of Optical and Physical Properties of Combustion-Generated Carbonaceous Aerosols (< PM sub(2.5)) Using Analytical and Microscopic Techniques AN - 1664217149; PQ0001240216 AB - A series of experiments were conducted to quantify and characterize the optical and physical properties of combustion-generated aerosols during both flaming and smoldering combustion of three materials common to underground mines-Pittsburgh Seam coal, Styrene Butadiene Rubber (a common mine conveyor belt material), and Douglas-fir wood-using a combination of analytical and gravimetric measurements. Laser photometers were utilized in the experiments for continuous measurement of aerosol mass concentrations and for comparison to measurements made using gravimetric filter samples. The aerosols of interest lie in the size range of tens to a few hundred nanometers, out of range of the standard photometer calibration. To correct for these uncertainties, the photometer mass concentrations were compared to gravimetric samples to determine if consistent correlations existed. The response of a calibrated and modified combination ionization/photoelectric smoke detector was also used. In addition, the responses of this sensor and a similar, prototype ionization/photoelectric sensor, along with discrete angular scattering, total scattering, and total extinction measurements, were used to define in real time the size, morphology, and radiative transfer properties of these differing aerosols that are generally in the form of fractal aggregates. SEM/TEM images were also obtained in order to compare qualitatively the real-time, continuous experimental measurements with the visual microscopic measurements. These data clearly show that significant differences exist between aerosols from flaming and from smoldering combustion and that these differences produce very different scattering and absorption signatures. The data also indicate that ionization/photoelectric sensors can be utilized to measure continuously and in real time aerosol properties over a broad spectrum of applications related to adverse environmental and health effects. JF - Fire Technology AU - Perera, Inoka Eranda AU - Litton, Charles D AD - Pittsburgh Research Laboratory, Fires and Explosions Branch, Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, Centers for Disease Control & Prevention, U. S. Department of Health & Human Services, 626 Cochrans Mill Road, PO Box 18070, Pittsburgh, PA, 15236, USA, eperera@cdc.gov Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 247 EP - 269 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 51 IS - 2 SN - 0015-2684, 0015-2684 KW - Health & Safety Science Abstracts KW - Styrene KW - Fires KW - Aerosols KW - Extinction KW - Sensors KW - Prototypes KW - Coal KW - Combustion KW - Smoke KW - Optical analysis KW - Morphology KW - Photometers KW - Lasers KW - Radiative transfer KW - H 7000:Fire Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664217149?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Fire+Technology&rft.atitle=Quantification+of+Optical+and+Physical+Properties+of+Combustion-Generated+Carbonaceous+Aerosols+%28%26lt%3B+PM+sub%282.5%29%29+Using+Analytical+and+Microscopic+Techniques&rft.au=Perera%2C+Inoka+Eranda%3BLitton%2C+Charles+D&rft.aulast=Perera&rft.aufirst=Inoka&rft.date=2015-03-01&rft.volume=51&rft.issue=2&rft.spage=247&rft.isbn=&rft.btitle=&rft.title=Fire+Technology&rft.issn=00152684&rft_id=info:doi/10.1007%2Fs10694-013-0376-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 22 N1 - Last updated - 2015-04-29 N1 - SubjectsTermNotLitGenreText - Styrene; Fires; Aerosols; Sensors; Extinction; Prototypes; Coal; Combustion; Optical analysis; Smoke; Morphology; Photometers; Lasers; Radiative transfer DO - http://dx.doi.org/10.1007/s10694-013-0376-z ER - TY - JOUR T1 - Impact of Natural IgM Concentration on Gene Therapy with Adenovirus Type 5 Vectors AN - 1664202634; PQ0001232820 AB - Natural IgM inhibits gene transfer by adenovirus type 5 (Ad5) vectors. We show that polyreactive natural IgM antibodies bind to Ad5 and that inhibition of liver transduction by IgM depends on Kupffer cells. By manipulating IgM concentration in vivo, we demonstrate that IgM inhibits liver transduction in a concentration-dependent manner. We further show that differences in natural IgM between BALB/c and C57BL/6 mice contribute to lower efficiency of Ad5 gene transfer in BALB/c mice. JF - Journal of Virology AU - Qiu, Qi AU - Xu, Zhili AU - Tian, Jie AU - Moitra, Rituparna AU - Gunti, Sreenivasulu AU - Notkins, Abner L AU - Byrnes, Andrew P AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA, Andrew.Byrnes@FDA.HHS.gov. PY - 2015 SP - 3412 EP - 3416 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 6 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Genetics Abstracts; Virology & AIDS Abstracts KW - Expression vectors KW - Kupffer cells KW - Gene therapy KW - Adenovirus KW - Liver KW - Immunoglobulin M KW - G 07720:Immunogenetics KW - W 30905:Medical Applications KW - V 22410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664202634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Impact+of+Natural+IgM+Concentration+on+Gene+Therapy+with+Adenovirus+Type+5+Vectors&rft.au=Qiu%2C+Qi%3BXu%2C+Zhili%3BTian%2C+Jie%3BMoitra%2C+Rituparna%3BGunti%2C+Sreenivasulu%3BNotkins%2C+Abner+L%3BByrnes%2C+Andrew+P&rft.aulast=Qiu&rft.aufirst=Qi&rft.date=2015-03-01&rft.volume=89&rft.issue=6&rft.spage=3412&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.03217-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 28 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Expression vectors; Kupffer cells; Gene therapy; Liver; Immunoglobulin M; Adenovirus DO - http://dx.doi.org/10.1128/JVI.03217-14 ER - TY - JOUR T1 - Antibody-Mediated Complement C3b/iC3b Binding to Group B Streptococcus in Paired Mother and Baby Serum Samples in a Refugee Population on the Thailand-Myanmar Border AN - 1664200068; PQ0001232512 AB - Streptococcus agalactiae (group B streptococcus [GBS]) is the leading cause of neonatal sepsis and meningitis. In this study, we determined antibody-mediated deposition of complement C3b/iC3b onto the bacterial cell surface of GBS serotypes Ia, Ib, II, III, and V. This was determined for 520 mother and umbilical cord serum sample pairs obtained at the time of birth from a population on the Thailand-Myanmar border. Antibody-mediated deposition of complement C3b/iC3b was detected to at least one serotype in 91% of mothers, despite a known carriage rate in this population of only 12%. Antibody-mediated C3b/iC3b deposition corresponded to known carriage rates, with the highest levels of complement deposition observed onto the most prevalent serotype (serotype II) followed by serotypes Ia, III, V, and Ib. Finally, neonates born to mothers carrying serotype II GBS at the time of birth showed higher antibody-mediated C3b/iC3b deposition against serotype II GBS than neonates born to mothers with no serotype II carriage. Assessment of antibody-mediated C3b/iC3b deposition against GBS may provide insights into the seroepidemiology of anti-GBS antibodies in mothers and infants in different populations. JF - Clinical and Vaccine Immunology AU - Herbert, Jenny AU - Thomas, Stephen AU - Brookes, Charlotte AU - Turner, Claudia AU - Turner, Paul AU - Nosten, Francois AU - Doare, Kirsty Le AU - Hudson, Michael AU - Heath, Paul T AU - Gorringe, Andrew AD - Public Health England, Porton Down, Salisbury, United Kingdom, stephen.taylor@phe.gov.uk. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 319 EP - 326 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 22 IS - 3 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell surface KW - Serotypes KW - Umbilical cord KW - Meningitis KW - Birth KW - Antibodies KW - Sepsis KW - Complement component C3b KW - Streptococcus agalactiae KW - Neonates KW - Seroepidemiology KW - Infants KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664200068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Antibody-Mediated+Complement+C3b%2FiC3b+Binding+to+Group+B+Streptococcus+in+Paired+Mother+and+Baby+Serum+Samples+in+a+Refugee+Population+on+the+Thailand-Myanmar+Border&rft.au=Herbert%2C+Jenny%3BThomas%2C+Stephen%3BBrookes%2C+Charlotte%3BTurner%2C+Claudia%3BTurner%2C+Paul%3BNosten%2C+Francois%3BDoare%2C+Kirsty+Le%3BHudson%2C+Michael%3BHeath%2C+Paul+T%3BGorringe%2C+Andrew&rft.aulast=Herbert&rft.aufirst=Jenny&rft.date=2015-03-01&rft.volume=22&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00803-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 46 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Birth; Cell surface; Sepsis; Antibodies; Serotypes; Complement component C3b; Seroepidemiology; Neonates; Umbilical cord; Meningitis; Infants; Streptococcus agalactiae DO - http://dx.doi.org/10.1128/CVI.00803-14 ER - TY - JOUR T1 - A scalable method to concentrate lentiviral vectors pseudotyped with measles virus glycoproteins AN - 1664196789; PQ0001238759 AB - Lentiviral (LV) vectors have emerged as powerful tools for basic research and clinical applications because of their ability to stably transduce both dividing and nondividing cells. A wide range of viral envelope (Env) glycoproteins have the ability to associate with the membrane of LV vectors, a process that is referred to as pseudotyping. Pseudotyped vectors have the capacity to transduce specific cell types for specific applications. For example, LV vectors pseudotyped with the measles virus (MV)-derived hemagglutinin (H) and fusion (F) proteins have the ability to transduce quiescent lymphocytes. In addition, the MV H glycoprotein can be engineered allowing cell-specific targeting of LV vectors. One problem with MV glycoprotein-pseudotyped LV vectors is low titer during vector production. This results in the need to manufacture large volumes of the vectors and to concentrate them to appropriate titers. The commonly used centrifugation-based concentration techniques for LV vectors are not practical for large-scale vector manufacturing. Thus, there is a need for improved methods to concentrate LV vectors. In this study, we adapted an anion-exchange membrane chromatography method that we previously used in the context of LV vectors pseudotyped with the vesicular stomatitis virus glycoprotein to concentate MV glycoprotein-pseudotyped LV vectors. Up to 60% of the input vectors with an up to 5300-fold reduction in volume was achieved using this anion-exchange chromatography method in conjunction with a desalting/concentration step involving centrifugal filter units. This technique provides a rapid and scalable approach for concentrating MV-pseudotyped LV vectors that does not require an elaborate setup. JF - Gene Therapy AU - Marino, M P AU - Panigaj, M AU - Ou, W AU - Manirarora, J AU - Wei, C-H AU - Reiser, J AD - Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA, Silver Spring, MD, USA Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 64 EP - 69 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 22 IS - 3 SN - 0969-7128, 0969-7128 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Anion-exchange chromatography KW - Filters KW - Envelopes KW - Gene therapy KW - Hemagglutinins KW - F protein KW - Therapeutic applications KW - Glycoproteins KW - Lymphocytes KW - Measles virus KW - Vesicular stomatitis virus KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664196789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=A+scalable+method+to+concentrate+lentiviral+vectors+pseudotyped+with+measles+virus+glycoproteins&rft.au=Marino%2C+M+P%3BPanigaj%2C+M%3BOu%2C+W%3BManirarora%2C+J%3BWei%2C+C-H%3BReiser%2C+J&rft.aulast=Marino&rft.aufirst=M&rft.date=2015-03-01&rft.volume=22&rft.issue=3&rft.spage=64&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fgt.2014.125 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Filters; Anion-exchange chromatography; Envelopes; Gene therapy; Hemagglutinins; F protein; Therapeutic applications; Lymphocytes; Glycoproteins; Measles virus; Vesicular stomatitis virus DO - http://dx.doi.org/10.1038/gt.2014.125 ER - TY - JOUR T1 - Intravenous and gastric cerium dioxide nanoparticle exposure disrupts microvascular smooth muscle signaling. AN - 1661333890; 25481005 AB - Cerium dioxide nanoparticles (CeO2 NP) hold great therapeutic potential, but the in vivo effects of non-pulmonary exposure routes are unclear. The first aim was to determine whether microvascular function is impaired after intravenous and gastric CeO2 NP exposure. The second aim was to investigate the mechanism(s) of action underlying microvascular dysfunction following CeO2 NP exposure. Rats were exposed to CeO2 NP (primary diameter: 4 ± 1 nm, surface area: 81.36 m(2)/g) by intratracheal instillation, intravenous injection, or gastric gavage. Mesenteric arterioles were harvested 24 h post-exposure and vascular function was assessed using an isolated arteriole preparation. Endothelium-dependent and independent function and vascular smooth muscle (VSM) signaling (soluble guanylyl cyclase [sGC] and cyclic guanosine monophosphate [cGMP]) were assessed. Reactive oxygen species (ROS) generation and nitric oxide (NO) production were analyzed. Compared with controls, endothelium-dependent and independent dilation were impaired following intravenous injection (by 61% and 45%) and gastric gavage (by 63% and 49%). However, intravenous injection resulted in greater microvascular impairment (16% and 35%) compared with gastric gavage at an identical dose (100 µg). Furthermore, sGC activation and cGMP responsiveness were impaired following pulmonary, intravenous, and gastric CeO2 NP treatment. Finally, nanoparticle exposure resulted in route-dependent, increased ROS generation and decreased NO production. These results indicate that CeO2 NP exposure route differentially impairs microvascular function, which may be mechanistically linked to decreased NO production and subsequent VSM signaling. Fully understanding the mechanisms behind CeO2 NP in vivo effects is a critical step in the continued therapeutic development of this nanoparticle. © The Author 2014. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Minarchick, Valerie C AU - Stapleton, Phoebe A AU - Fix, Natalie R AU - Leonard, Stephen S AU - Sabolsky, Edward M AU - Nurkiewicz, Timothy R AD - *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506 *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506. ; *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506. ; *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506 *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506 *Center for Cardiovascular and Respiratory Sciences and Department of Physiology and Pharmacology, West Virginia University School of Medicine, Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health and Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506 tnurkiewicz@hsc.wvu.edu. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 77 EP - 89 VL - 144 IS - 1 KW - Reactive Oxygen Species KW - 0 KW - Receptors, Cytoplasmic and Nuclear KW - Cerium KW - 30K4522N6T KW - Nitric Oxide KW - 31C4KY9ESH KW - ceric oxide KW - 619G5K328Y KW - Guanylate Cyclase KW - EC 4.6.1.2 KW - Soluble Guanylyl Cyclase KW - Cyclic GMP KW - H2D2X058MU KW - Index Medicus KW - cerium dioxide nanoparticles; microvascular function; nitric oxide; mesentery KW - Administration, Oral KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Particle Size KW - Intubation, Gastrointestinal KW - Nitric Oxide -- metabolism KW - Epithelial Cells -- metabolism KW - Guanylate Cyclase -- metabolism KW - Rats, Sprague-Dawley KW - Cyclic GMP -- metabolism KW - Epithelial Cells -- drug effects KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Administration, Inhalation KW - Male KW - Myocytes, Smooth Muscle -- drug effects KW - Arterioles -- metabolism KW - Signal Transduction -- drug effects KW - Muscle, Smooth, Vascular -- drug effects KW - Mesentery -- blood supply KW - Vasodilation -- drug effects KW - Myocytes, Smooth Muscle -- metabolism KW - Muscle, Smooth, Vascular -- metabolism KW - Nanoparticles KW - Cerium -- toxicity KW - Arterioles -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1661333890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Intravenous+and+gastric+cerium+dioxide+nanoparticle+exposure+disrupts+microvascular+smooth+muscle+signaling.&rft.au=Minarchick%2C+Valerie+C%3BStapleton%2C+Phoebe+A%3BFix%2C+Natalie+R%3BLeonard%2C+Stephen+S%3BSabolsky%2C+Edward+M%3BNurkiewicz%2C+Timothy+R&rft.aulast=Minarchick&rft.aufirst=Valerie&rft.date=2015-03-01&rft.volume=144&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu256 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-30 N1 - Date created - 2015-03-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cardiovasc Res. 2002 Aug 1;55(2):250-60 [12123764] Ann Med. 2003;35(1):21-7 [12693609] Circ Res. 2003 Aug 22;93(4):280-91 [12933699] Mol Pharmacol. 2004 May;65(5):1111-9 [15102939] Adv Drug Deliv Rev. 2004 Sep 22;56(11):1649-59 [15350294] Front Biosci. 2004 Sep 1;9:3434-46 [15353368] Free Radic Biol Med. 1987;3(4):259-303 [2826304] Free Radic Res Commun. 1987;3(6):357-64 [2854531] Am J Physiol. 1992 Nov;263(5 Pt 2):H1486-91 [1443200] Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6529-34 [9177252] Am J Physiol Gastrointest Liver Physiol. 2006 Mar;290(3):G535-42 [16269521] Biomaterials. 2008 Jun;29(18):2705-9 [18395249] Circ Res. 2008 May 23;102(10):1148-50 [18497313] Toxicol Sci. 2009 Feb;107(2):342-51 [19023088] Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H359-69 [19060128] Toxicol Sci. 2009 Jul;110(1):191-203 [19270016] Inhal Toxicol. 2009 Jul;21 Suppl 1:123-30 [19558244] Cardiovasc Toxicol. 2010 Mar;10(1):27-36 [20033351] Mol Biosyst. 2010 Oct;6(10):1813-20 [20697616] Environ Health Perspect. 2011 Jan;119(1):98-103 [20870565] J Exp Ther Oncol. 2011;9(1):47-51 [21275265] Crit Rev Toxicol. 2011 Mar;41(3):213-29 [21244219] Toxicol Lett. 2011 Aug 28;205(2):105-15 [21624445] Nanotoxicology. 2011 Sep;5(3):312-25 [20925443] Nanotoxicology. 2011 Dec;5(4):531-45 [21043986] Int J Nanomedicine. 2011;6:2327-35 [22072870] Toxicol Sci. 2012 May;127(1):256-68 [22367688] Toxicol Sci. 2012 Jun;127(2):463-73 [22430073] ACS Nano. 2012 May 22;6(5):3767-75 [22524692] Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11039-43 [22968916] Environ Toxicol. 2013 Feb;28(2):107-18 [21618676] Cardiovasc Toxicol. 2013 Dec;13(4):323-37 [23645470] Part Fibre Toxicol. 2014;11:13 [24666995] Am J Physiol Heart Circ Physiol. 2000 Aug;279(2):H459-65 [10924042] J Pathol. 2000 Feb;190(3):244-54 [10685059] Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Jul-Aug;6(4):338-48 [24777845] Semin Thromb Hemost. 2000;26(5):539-45 [11129410] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu256 ER - TY - JOUR T1 - FDA approval: siltuximab for the treatment of patients with multicentric Castleman disease. AN - 1660655146; 25601959 AB - On April 22, 2014, the FDA granted full approval to siltuximab (SYLVANT for injection; Janssen Biotech, Inc.), a chimeric human-mouse monoclonal antibody to IL6, for the treatment of patients with multicentric Castleman disease (MCD) who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative. The approval was primarily based on the results of a randomized, double-blind trial in which 79 symptomatic patients with MCD were allocated (2:1) to siltuximab plus best supportive care (BSC) or to placebo plus BSC. The primary efficacy endpoint was the proportion of patients in each arm achieving a durable tumor and symptomatic response that persisted for a minimum of 18 weeks without treatment failure. Tumor response was based on independent review of CT scans using the revised Response Criteria for Malignant Lymphoma, and symptomatic response was defined as complete resolution or stabilization of 34 MCD-related signs and symptoms as reported by the investigator. Thirty-four percent of patients in the siltuximab arm and no patients in the placebo arm met the primary endpoint (P = 0.0012). The most common adverse reactions (>10% compared with placebo) during treatment with siltuximab were pruritus, increased weight, rash, hyperuricemia, and upper respiratory tract infection. ©2015 American Association for Cancer Research. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Deisseroth, Albert AU - Ko, Chia-Wen AU - Nie, Lei AU - Zirkelbach, Jeanne F AU - Zhao, Liang AU - Bullock, Julie AU - Mehrotra, Nitin AU - Del Valle, Pedro AU - Saber, Haleh AU - Sheth, Christopher AU - Gehrke, Brenda AU - Justice, Robert AU - Farrell, Ann AU - Pazdur, Richard AD - Office of Hematology and Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Albert.Deisseroth@fda.hhs.gov. ; Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. ; Office of Hematology and Oncology Drug Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland. Y1 - 2015/03/01/ PY - 2015 DA - 2015 Mar 01 SP - 950 EP - 954 VL - 21 IS - 5 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - siltuximab KW - Index Medicus KW - United States KW - Animals KW - Humans KW - Adult KW - Treatment Outcome KW - Clinical Trials as Topic KW - Aged KW - Middle Aged KW - Drug Evaluation, Preclinical KW - United States Food and Drug Administration KW - Giant Lymph Node Hyperplasia -- diagnosis KW - Giant Lymph Node Hyperplasia -- drug therapy KW - Drug Approval KW - Antibodies, Monoclonal -- pharmacology KW - Antibodies, Monoclonal -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- chemistry KW - Antineoplastic Agents -- pharmacology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660655146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=FDA+approval%3A+siltuximab+for+the+treatment+of+patients+with+multicentric+Castleman+disease.&rft.au=Deisseroth%2C+Albert%3BKo%2C+Chia-Wen%3BNie%2C+Lei%3BZirkelbach%2C+Jeanne+F%3BZhao%2C+Liang%3BBullock%2C+Julie%3BMehrotra%2C+Nitin%3BDel+Valle%2C+Pedro%3BSaber%2C+Haleh%3BSheth%2C+Christopher%3BGehrke%2C+Brenda%3BJustice%2C+Robert%3BFarrell%2C+Ann%3BPazdur%2C+Richard&rft.aulast=Deisseroth&rft.aufirst=Albert&rft.date=2015-03-01&rft.volume=21&rft.issue=5&rft.spage=950&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-1678 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-03-18 N1 - Date created - 2015-03-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: Clin Cancer Res. 2015 Oct 15;21(20):4740 [26473194] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-1678 ER - TY - JOUR T1 - Occupational burns treated in emergency departments AN - 1660417328; PQ0001110016 AB - Background Despite reported declines, occupational burn injuries remain a workplace safety concern. More severe burns may result in costly medical treatment and long-term physical and psychological consequences. Methods We used the National Electronic Injury Surveillance System-Occupational Supplement to produce national estimates of burns treated in emergency departments (EDs). We analyzed data trends from 1999 to 2008 and provided detailed descriptions of 2008 data. Results From 1999 to 2008 there were 1,132,000 (95% CI: plus or minus 192,300) nonfatal occupational burns treated in EDs. Burn numbers and rates declined approximately 40% over the 10 years. In 2008, men and younger workers 15-24 years old had the highest rates. Scalds and thermal burns accounted for more than 60% of burns. Accommodation and food service, manufacturing, and construction industries had the largest number of burns. Conclusions Despite declining burn rates, emphasis is needed on reducing burn hazards to young food service workers and using job specific hazard analyses to prevent burns. Am. J. Ind. Med. 58:290-298, 2015. copyright 2015 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Reichard, Audrey A AU - Konda, Srinivas AU - Jackson, Larry L AD - Division of Safety Research, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 290 EP - 298 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 3 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Burns KW - Injuries KW - Psychology KW - Occupational safety KW - Medical treatment KW - Construction industry KW - Emergency medical services KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660417328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Occupational+burns+treated+in+emergency+departments&rft.au=Reichard%2C+Audrey+A%3BKonda%2C+Srinivas%3BJackson%2C+Larry+L&rft.aulast=Reichard&rft.aufirst=Audrey&rft.date=2015-03-01&rft.volume=58&rft.issue=3&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Burns; Injuries; Psychology; Occupational safety; Medical treatment; Construction industry; Emergency medical services DO - http://dx.doi.org/10.1002/ajim.22407 ER - TY - JOUR T1 - Breast cancer incidence in a cohort of U.S. flight attendants AN - 1660415118; PQ0001110017 AB - Background Flight attendants may have elevated breast cancer incidence (BCI). We evaluated BCI's association with cosmic radiation dose and circadian rhythm disruption among 6,093 female former U.S. flight attendants. Methods We collected questionnaire data on BCI and risk factors for breast cancer from 2002-2005. We conducted analyses to evaluate (i) BCI in the cohort compared to the U.S. population; and (ii) exposure-response relations. We applied an indirect adjustment to estimate whether parity and age at first birth (AFB) differences between the cohort and U.S. population could explain BCI that differed from expectation. Results BCI was elevated but may be explained by lower parity and older AFB in the cohort than among U.S. women. BCI was not associated with exposure metrics in the cohort overall. Significant positive associations with both were observed only among women with parity of three or more. Conclusions Future cohort analyses may be informative on the role of these occupational exposures and non-occupational risk factors. Am. J. Ind. Med. 58:252-266, 2015. copyright 2015 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Schubauer-Berigan, Mary K AU - Anderson, Jeri L AU - Hein, Misty J AU - Little, Mark P AU - Sigurdson, Alice J AU - Pinkerton, Lynne E AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Industrywide Studies Branch, Cincinnati, Ohio. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - 252 EP - 266 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 3 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Parity KW - Health risks KW - Age KW - Risk factors KW - Dose-response effects KW - Cosmic radiation KW - Circadian rhythms KW - Breast cancer KW - Crew safety KW - Occupational exposure KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660415118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Breast+cancer+incidence+in+a+cohort+of+U.S.+flight+attendants&rft.au=Schubauer-Berigan%2C+Mary+K%3BAnderson%2C+Jeri+L%3BHein%2C+Misty+J%3BLittle%2C+Mark+P%3BSigurdson%2C+Alice+J%3BPinkerton%2C+Lynne+E&rft.aulast=Schubauer-Berigan&rft.aufirst=Mary&rft.date=2015-03-01&rft.volume=58&rft.issue=3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22419 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Parity; Health risks; Age; Dose-response effects; Risk factors; Cosmic radiation; Circadian rhythms; Breast cancer; Crew safety; Occupational exposure DO - http://dx.doi.org/10.1002/ajim.22419 ER - TY - JOUR T1 - Developmental toxicity assay using high content screening of zebrafish embryos AN - 1660398592; PQ0001007588 AB - Typically, time-consuming standard toxicological assays using the zebrafish (Danio rerio) embryo model evaluate mortality and teratogenicity after exposure during the first 2days post-fertilization. Here we describe an automated image-based high content screening (HCS) assay to identify the teratogenic/embryotoxic potential of compounds in zebrafish embryos in vivo. Automated image acquisition was performed using a high content microscope system. Further automated analysis of embryo length, as a statistically quantifiable endpoint of toxicity, was performed on images post-acquisition. The biological effects of ethanol, nicotine, ketamine, caffeine, dimethyl sulfoxide and temperature on zebrafish embryos were assessed. This automated developmental toxicity assay, based on a growth-retardation endpoint should be suitable for evaluating the effects of potential teratogens and developmental toxicants in a high throughput manner. This approach can significantly expedite the screening of potential teratogens and developmental toxicants, thereby improving the current risk assessment process by decreasing analysis time and required resources. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. High content assay quantifies developmental toxicity in zebrafish embryos. JF - Journal of Applied Toxicology AU - Lantz-McPeak, Susan AU - Guo, Xiaoqing AU - Cuevas, Elvis AU - Dumas, Melanie AU - Newport, Glenn D AU - Ali, Syed F AU - Paule, Merle G AU - Kanungo, Jyotshna AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 261 EP - 272 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 35 IS - 3 SN - 0260-437X, 0260-437X KW - ASFA 1: Biological Sciences & Living Resources; Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Risk assessment KW - Toxicants KW - Freshwater fish KW - Models KW - Nicotine KW - Ketamine KW - Embryos KW - Caffeine KW - Ethanol KW - Abiotic factors KW - Temperature effects KW - Screening KW - Mortality KW - Microscopes KW - Temperature KW - Embryonic development KW - Assays KW - Toxicity KW - Danio rerio KW - USA KW - Biological effects KW - Dimethyl sulfoxide KW - Teratogenicity KW - Teratogens KW - Mortality causes KW - X 24380:Social Poisons & Drug Abuse KW - H 14000:Toxicology KW - Q1 08604:Stock assessment and management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660398592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Developmental+toxicity+assay+using+high+content+screening+of+zebrafish+embryos&rft.au=Lantz-McPeak%2C+Susan%3BGuo%2C+Xiaoqing%3BCuevas%2C+Elvis%3BDumas%2C+Melanie%3BNewport%2C+Glenn+D%3BAli%2C+Syed+F%3BPaule%2C+Merle+G%3BKanungo%2C+Jyotshna&rft.aulast=Lantz-McPeak&rft.aufirst=Susan&rft.date=2015-03-01&rft.volume=35&rft.issue=3&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Screening; Toxicants; Embryonic development; Teratogens; Toxicity; Freshwater fish; Mortality causes; Abiotic factors; Risk assessment; Temperature effects; Mortality; Microscopes; Models; Nicotine; Dimethyl sulfoxide; Ketamine; Caffeine; Embryos; Teratogenicity; Ethanol; Temperature; Assays; Biological effects; Danio rerio; USA DO - http://dx.doi.org/10.1002/jat.3029 ER - TY - JOUR T1 - Abnormalities in the male reproductive system after exposure to diesel and biodiesel blend. AN - 1658420177; 25327512 AB - Altering the fuel source from petroleum-based ultralow sulfur diesel to biodiesel and its blends is considered by many to be a sustainable choice for controlling exposures to particulate material. As the exhaust of biodiesel/diesel blends is composed of a combination of combustion products of polycyclic aromatic hydrocarbons and fatty acid methyl esters, we hypothesize that 50% biodiesel/diesel blend (BD50) exposure could induce harmful outcomes because of its ability to trigger oxidative damage. Here, adverse effects were compared in murine male reproductive organs after pharyngeal aspiration with particles generated by engine fueled with BD50 or neat petroleum diesel (D100). When compared with D100, exposure to BD50 significantly altered sperm integrity, including concentration, motility, and morphological abnormalities, as well as increasing testosterone levels in testes during the time course postexposure. Serum level of luteinizing hormone was significantly depleted only after BD50 exposure. Moreover, we observed that exposure to BD50 significantly increased sperm DNA fragmentation and the upregulation of inflammatory cytokines in the serum and testes on Day 7 postexposure when compared with D100. Histological evaluation of testes sections from BD50 exposure indicated more noticeable interstitial edema, degenerating spermatocytes, and dystrophic seminiferous tubules with arrested spermatogenesis. Significant differences in the level of oxidative stress assessed by accumulation of lipid peroxidation products and depletion of glutathione were detected on exposure to respirable BD50 and D100. Taken together, these results indicate that exposure of mice to inhalable BD50 caused more pronounced adverse effects on male reproductive function than diesel. © 2014 Wiley Periodicals, Inc. JF - Environmental and molecular mutagenesis AU - Kisin, Elena R AU - Yanamala, Naveena AU - Farcas, Mariana T AU - Gutkin, Dmitriy W AU - Shurin, Michael R AU - Kagan, Valerian E AU - Bugarski, Aleksandar D AU - Shvedova, Anna A AD - Pathology and Physiology Research Branch, and Exposure Assessment Branch, HELD, NIOSH, Morgantown, West Virginia. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 265 EP - 276 VL - 56 IS - 2 KW - Biofuels KW - 0 KW - Gasoline KW - Petroleum KW - Vehicle Emissions KW - Index Medicus KW - biodiesel particles KW - DNA fragmentation KW - male reproduction KW - sperm quality KW - pulmonary exposure KW - oxidative stress KW - Animals KW - Vehicle Emissions -- toxicity KW - Testis -- drug effects KW - Humans KW - Gasoline -- adverse effects KW - DNA Fragmentation -- drug effects KW - Petroleum -- adverse effects KW - Mice KW - Male KW - Biofuels -- adverse effects KW - Reproduction -- drug effects KW - Spermatozoa -- drug effects KW - Oxidative Stress -- drug effects KW - Lipid Peroxidation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658420177?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+molecular+mutagenesis&rft.atitle=Abnormalities+in+the+male+reproductive+system+after+exposure+to+diesel+and+biodiesel+blend.&rft.au=Kisin%2C+Elena+R%3BYanamala%2C+Naveena%3BFarcas%2C+Mariana+T%3BGutkin%2C+Dmitriy+W%3BShurin%2C+Michael+R%3BKagan%2C+Valerian+E%3BBugarski%2C+Aleksandar+D%3BShvedova%2C+Anna+A&rft.aulast=Kisin&rft.aufirst=Elena&rft.date=2015-03-01&rft.volume=56&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Environmental+and+molecular+mutagenesis&rft.issn=1098-2280&rft_id=info:doi/10.1002%2Fem.21915 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-22 N1 - Date created - 2015-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/em.21915 ER - TY - JOUR T1 - Haptoglobin attenuates hemoglobin-induced heme oxygenase-1 in renal proximal tubule cells and kidneys of a mouse model of sickle cell disease. AN - 1658419024; 25582460 AB - Sickle cell disease (SCD), a hereditary hemolytic disorder is characterized by chronic hemolysis, oxidative stress, vaso-occlusion and end-organ damage. Hemolysis releases toxic cell-free hemoglobin (Hb) into circulation. Under physiologic conditions, plasma Hb binds to haptoglobin (Hp) and forms Hb-Hp dimers. The dimers bind to CD163 receptors on macrophages for further internalization and degradation. However, in SCD patients plasma Hp is depleted and free Hb is cleared primarily by proximal tubules of kidneys. Excess free Hb in plasma predisposes patients to renal damage. We hypothesized that administration of exogenous Hp reduces Hb-mediated renal damage. To test this hypothesis, human renal proximal tubular cells (HK-2) were exposed to HbA (50μM heme) for 24h. HbA increased the expression of heme oxygenase-1 (HO-1), an enzyme which degrades heme, reduces heme-mediated oxidative toxicity, and confers cytoprotection. Similarly, infusion of HbA (32μM heme/kg) induced HO-1 expression in kidneys of SCD mice. Immunohistochemistry confirmed the increased HO-1 expression in the proximal tubules of the kidney. Exogenous Hp attenuated the HbA-induced HO-1 expression in vitro and in SCD mice. Our results suggest that Hb-mediated oxidative toxicity may contribute to renal damage in SCD and that Hp treatment reduces heme/iron toxicity in the kidneys following hemolysis. Published by Elsevier Inc. JF - Blood cells, molecules & diseases AU - Chintagari, Narendranath Reddy AU - Nguyen, Julia AU - Belcher, John D AU - Vercellotti, Gregory M AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. ; University of Minnesota, Department of Medicine, Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Minneapolis, MN 55455, USA. ; Laboratory of Biochemistry and Vascular Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993, USA. Electronic address: abdu.alayash@fda.hhs.gov. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 302 EP - 306 VL - 54 IS - 3 KW - Haptoglobins KW - 0 KW - Hemoglobin A KW - 9034-51-9 KW - Heme Oxygenase-1 KW - EC 1.14.14.18 KW - Index Medicus KW - Kidney proximal tubules KW - Haptoglobin KW - Kidney damage KW - Sickle cell disease KW - Hemeoxygenase-1 KW - Animals KW - Kidney Tubules -- pathology KW - Kidney Tubules -- cytology KW - Humans KW - Oxidative Stress KW - Mice, Inbred C57BL KW - Disease Models, Animal KW - Mice KW - Male KW - Female KW - Cell Line KW - Kidney -- metabolism KW - Kidney -- pathology KW - Anemia, Sickle Cell -- metabolism KW - Heme Oxygenase-1 -- metabolism KW - Anemia, Sickle Cell -- complications KW - Hemoglobin A -- metabolism KW - Haptoglobins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658419024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood+cells%2C+molecules+%26+diseases&rft.atitle=Haptoglobin+attenuates+hemoglobin-induced+heme+oxygenase-1+in+renal+proximal+tubule+cells+and+kidneys+of+a+mouse+model+of+sickle+cell+disease.&rft.au=Chintagari%2C+Narendranath+Reddy%3BNguyen%2C+Julia%3BBelcher%2C+John+D%3BVercellotti%2C+Gregory+M%3BAlayash%2C+Abdu+I&rft.aulast=Chintagari&rft.aufirst=Narendranath&rft.date=2015-03-01&rft.volume=54&rft.issue=3&rft.spage=302&rft.isbn=&rft.btitle=&rft.title=Blood+cells%2C+molecules+%26+diseases&rft.issn=1096-0961&rft_id=info:doi/10.1016%2Fj.bcmd.2014.12.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-23 N1 - Date created - 2015-02-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Blood. 2013 Mar 14;121(11):2099-107 [23349388] Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):12150-4 [1465454] Cold Spring Harb Perspect Med. 2013 Jun;3(6). pii: a013433. doi: 10.1101/cshperspect.a013433 [23645855] Am J Physiol Lung Cell Mol Physiol. 2014 Jan 1;306(1):L88-100 [24142518] Blood. 2014 Jan 16;123(3):377-90 [24277079] Free Radic Biol Med. 2014 Apr;69:265-77 [24486321] Trends Biotechnol. 2014 Apr;32(4):177-85 [24630491] J Biol Chem. 2014 Aug 8;289(32):22342-57 [24939847] JAMA. 2014 Nov 26;312(20):2115-25 [25393378] J Clin Invest. 2006 Mar;116(3):808-16 [16485041] J Clin Invest. 2007 Apr;117(4):850-8 [17404610] Blood. 2009 Mar 12;113(11):2578-86 [19131549] J Clin Invest. 2009 Aug;119(8):2271-80 [19620788] J Biol Chem. 2009 Oct 23;284(43):29582-95 [19700768] Annu Rev Pharmacol Toxicol. 2010;50:323-54 [20055707] Eur J Haematol. 2010 Jan 1;84(1):72-8 [19732137] PLoS One. 2010;5(2):e9228 [20169059] PLoS One. 2010;5(11):e14171 [21152393] Clin Chim Acta. 2011 Mar 18;412(7-8):493-8 [21159311] Science. 2011 Dec 2;334(6060):1283-6 [22075726] Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):421-6 [22138393] J Clin Invest. 2012 Apr;122(4):1444-58 [22446185] J Am Soc Nephrol. 2012 May;23(5):781-4 [22440903] Br J Haematol. 2012 Jun;157(5):599-605 [22409346] J Biol Chem. 2013 Feb 8;288(6):4288-98 [23264625] J Am Soc Nephrol. 2002 Feb;13(2):423-30 [11805171] Nat Med. 2002 Dec;8(12):1383-9 [12426562] Blood. 2003 May 15;101(10):3953-9 [12543857] J Biol Chem. 1968 Feb 10;243(3):465-75 [4966113] Blood. 1968 Nov;32(5):811-5 [5687939] Proc Natl Acad Sci U S A. 1988 Jan;85(1):237-41 [3422420] PLoS One. 2013;8(3):e59841 [23555800] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bcmd.2014.12.001 ER - TY - JOUR T1 - (Q)SAR assessments of potentially mutagenic impurities: a regulatory perspective on the utility of expert knowledge and data submission. AN - 1658416389; 25545315 AB - (Quantitative) structure activity relationship [(Q)SAR] modeling is the primary tool used to evaluate the mutagenic potential associated with drug impurities. General recommendations regarding the use of (Q)SAR in regulatory decision making have recently been provided in the ICH M7 guideline. Although (Q)SAR alone is capable of achieving reasonable sensitivity and specificity, reliance on a simple positive or negative prediction can be problematic. The key to improving (Q)SAR performance is to integrate supporting information, also referred to as expert knowledge, into the final conclusion. In the regulatory context, expert knowledge is intended to (1) maximize confidence in a (Q)SAR prediction, (2) provide rationale to supersede a positive or negative (Q)SAR prediction, or (3) provide a basis for assessing mutagenicity in absence of a (Q)SAR prediction. Expert knowledge is subjective and is associated with great variability in regards to content and quality. However, it is still a critical component of impurity evaluations and its utility is acknowledged in the ICH M7 guideline. The current paper discusses the use of expert knowledge to support regulatory decision making, describes case studies, and provides recommendations for reporting data from (Q)SAR evaluations. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Powley, Mark W AD - Division of Antiviral Products, Office of New Drugs, Center for Drug Evaluation and Research, US FDA, WO 22/RM 6389, 10903 New Hampshire Ave., Silver Spring, MD 20993, United States. Electronic address: mark.powley@fda.hhs.gov. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 295 EP - 300 VL - 71 IS - 2 KW - Mutagens KW - 0 KW - Index Medicus KW - ICH M7 KW - Mutagenicity KW - (Q)SAR KW - Drug impurities KW - Humans KW - Mutagenicity Tests -- standards KW - Drug Contamination -- prevention & control KW - Quantitative Structure-Activity Relationship KW - Databases, Factual -- legislation & jurisprudence KW - Expert Systems KW - Drug Contamination -- legislation & jurisprudence KW - Databases, Factual -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658416389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=%28Q%29SAR+assessments+of+potentially+mutagenic+impurities%3A+a+regulatory+perspective+on+the+utility+of+expert+knowledge+and+data+submission.&rft.au=Powley%2C+Mark+W&rft.aulast=Powley&rft.aufirst=Mark&rft.date=2015-03-01&rft.volume=71&rft.issue=2&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.12.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.12.012 ER - TY - JOUR T1 - Estimation of the chemical-induced eye injury using a weight-of-evidence (WoE) battery of 21 artificial neural network (ANN) c-QSAR models (QSAR-21): part I: irritation potential. AN - 1658416317; 25497990 AB - Evaluation of potential chemical-induced eye injury through irritation and corrosion is required to ensure occupational and consumer safety for industrial, household and cosmetic ingredient chemicals. The historical method for evaluating eye irritant and corrosion potential of chemicals is the rabbit Draize test. However, the Draize test is controversial and its use is diminishing - the EU 7th Amendment to the Cosmetic Directive (76/768/EEC) and recast Regulation now bans marketing of new cosmetics having animal testing of their ingredients and requires non-animal alternative tests for safety assessments. Thus, in silico and/or in vitro tests are advocated. QSAR models for eye irritation have been reported for several small (congeneric) data sets; however, large global models have not been described. This report describes FDA/CFSAN's development of 21 ANN c-QSAR models (QSAR-21) to predict eye irritation using the ADMET Predictor program and a diverse training data set of 2928 chemicals. The 21 models had external (20% test set) and internal validation and average training/verification/test set statistics were: 88/88/85(%) sensitivity and 82/82/82(%) specificity, respectively. The new method utilized multiple artificial neural network (ANN) molecular descriptor selection functionalities to maximize the applicability domain of the battery. The eye irritation models will be used to provide information to fill the critical data gaps for the safety assessment of cosmetic ingredient chemicals. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Verma, Rajeshwar P AU - Matthews, Edwin J AD - Office of Cosmetics and Colors, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, United States; Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, United States. Electronic address: Rajeshwar.Verma@fda.hhs.gov. ; Office of Food Additive Safety, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, United States. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 318 EP - 330 VL - 71 IS - 2 KW - Cosmetics KW - 0 KW - Irritants KW - Index Medicus KW - c-QSAR KW - QSAR-21 KW - Eye irritation KW - Artificial neural network KW - Weight of evidence KW - Animals KW - Rabbits KW - Quantitative Structure-Activity Relationship KW - Irritants -- administration & dosage KW - Neural Networks (Computer) KW - Cosmetics -- administration & dosage KW - Irritants -- toxicity KW - Animal Testing Alternatives -- methods KW - Eye Injuries -- chemically induced KW - Cosmetics -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658416317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Estimation+of+the+chemical-induced+eye+injury+using+a+weight-of-evidence+%28WoE%29+battery+of+21+artificial+neural+network+%28ANN%29+c-QSAR+models+%28QSAR-21%29%3A+part+I%3A+irritation+potential.&rft.au=Verma%2C+Rajeshwar+P%3BMatthews%2C+Edwin+J&rft.aulast=Verma&rft.aufirst=Rajeshwar&rft.date=2015-03-01&rft.volume=71&rft.issue=2&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.11.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.11.011 ER - TY - JOUR T1 - Hep-2 cell based indirect immunofluorescence assay for antinuclear antibodies as a potential diagnosis of drug-induced autoimmunity in nonclinical toxicity testing. AN - 1658416265; 25455225 AB - Antinuclear antibodies (ANAs) are important biomarkers in the diagnosis of autoimmune diseases in humans; however, the diagnostic performance of ANA in nonclinical safety studies are not well understood. Here, we studied the use of ANAs as potential nonclinical biomarkers for drug-induced autoimmunity (DIA) using a Hep-2 based indirect immunofluorescence assay (IFA). Initially, MRL-fas(lpr)/J mice and HgCl₂-treated rats were used as SLE-positive models. Serum samples obtained from 94 normal mice or 204 normal rats aged one to four months served as the negative control. The IFA effectively distinguished ANAs-positive samples in both species with a cut-off titer of 1:100. Brown Norway rats were treated with 450 mg/kg D-penicillamine for 30 consecutive days. ANAs were generated and corresponded with DIA development. Human Hep-2 cells, mice Neuro 2A cells, and Chinese Hamster Lung cells served as antigen from different species, which were found cross-reactive with ANA-positive serum samples from mice, rats, and humans without any differences in diagnosis. This methodology showed no species-specificity for ANA detection. Furthermore, we found approximately 20 percentage of the mice aged seven to eight months demonstrated age-related ANAs, which was consistent with humans. Overall, our findings demonstrated the use of ANA detection using IFA in the nonclinical diagnosis of murine drug-induced autoimmunity, and age-related ANAs should be considered when aged animals are used. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Hong, Min AU - Ma, Ben AU - Lin, Zhi AU - Zhou, Xiaobing AU - Geng, Xingchao AU - Shen, Lianzhong AU - Li, Bo AD - National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, China Food and Drug Administration, 100176 Beijing, People's Republic of China. ; National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, China Food and Drug Administration, 100176 Beijing, People's Republic of China. Electronic address: libo@nifdc.org.cn. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 141 EP - 147 VL - 71 IS - 2 KW - Antibodies, Antinuclear KW - 0 KW - Index Medicus KW - Drug-induced autoimmunity (DIA) KW - Age-related ANAs KW - Biomarker KW - Antinuclear antibodies (ANAs) KW - Animals KW - Cricetulus KW - Humans KW - Cell Line, Tumor KW - Mice KW - Rats, Inbred BN KW - Mice, Inbred BALB C KW - Rats KW - Fluorescent Antibody Technique, Indirect -- methods KW - Hep G2 Cells KW - Rats, Wistar KW - Microscopy, Fluorescence -- methods KW - Female KW - Male KW - Cricetinae KW - Autoimmunity -- immunology KW - Autoimmunity -- drug effects KW - Toxicity Tests -- methods KW - Antibodies, Antinuclear -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658416265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Hep-2+cell+based+indirect+immunofluorescence+assay+for+antinuclear+antibodies+as+a+potential+diagnosis+of+drug-induced+autoimmunity+in+nonclinical+toxicity+testing.&rft.au=Hong%2C+Min%3BMa%2C+Ben%3BLin%2C+Zhi%3BZhou%2C+Xiaobing%3BGeng%2C+Xingchao%3BShen%2C+Lianzhong%3BLi%2C+Bo&rft.aulast=Hong&rft.aufirst=Min&rft.date=2015-03-01&rft.volume=71&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-22 N1 - Date created - 2015-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.10.005 ER - TY - JOUR T1 - Relationship between ambient ultraviolet radiation and non-Hodgkin lymphoma subtypes: A U.S. population-based study of racial and ethnic groups AN - 1654666065; 21180146 AB - Associations between ultraviolet radiation (UVR) exposure and non-Hodgkin lymphoma (NHL) have been inconsistent, but few studies have examined these associations for specific subtypes or across race/ethnicities. We evaluated the relationship between ambient UVR exposure and subtype-specific NHL incidence for whites, Hispanics and blacks in the United States for years 2001-2010 (n=187,778 cases). Incidence rate ratios (IRRs) and 95% confidence intervals (CIs) were calculated for UVR quintiles using Poisson regression. Incidence was lower for the highest UVR quintile for chronic/small lymphocytic/leukemia (CLL/SLL) (IRR=0.87, 95% CI: 0.77-0.97), mantle cell (IRR=0.82, 95% CI: 0.69-0.97), lymphoplasmacytic (IRR=0.58, 95% CI: 0.42-0.80), mucosa-associated lymphoid tissue (MZLMALT) (IRR=0.74, 95% CI: 0.60-0.90), follicular (FL) (IRR=0.76, 95% CI: 0.68-0.86), diffuse large B-cell (IRR=0.84, 95% CI: 0.76-0.94; ), peripheral T-cell other (PTCL) (IRR=0.76, 95% CI: 0.61-0.95) and PTCL not otherwise specified (PNOS) (IRR=0.77, 95% CI: 0.61-0.98). Trends were significant for MZLMALT, FL, DLBCL, BNOS and PTCL, with FL and DLBCL still significant after Bonferroni correction. We found interaction by race/ethnicity for CLL/SLL, FL, Burkitt, PNOS and MF/SS, with CLL/SLL and FL still significant after Bonferroni correction. Some B-cell lymphomas (CLL/SLL, FL and Burkitt) suggested significant inverse relationships in whites and Hispanics, but not in blacks. Some T-cell lymphomas suggested the most reduced risk for the highest quintile of UVR among blacks (PNOS and MF/SS), though trends were not significant. These findings strengthen the case for an inverse association of UVR exposure, support modest heterogeneity between NHL subtypes and suggest some differences by race/ethnicity. What's new? Studies have yielded mix results as to whether exposure to ultraviolet radiation (UVR) increases or decreases risk of non-Hodgkin lymphoma (NHL). In the present analysis of data from population-based cancer registries in the United States, increasing ambient UVR exposure was associated with a reduction in risk of most NHL subtypes, The reduction occurred for all races, including non-Hispanic whites, Hispanic whites, and blacks. The findings emphasize the importance of exploring NHL etiology according to subtypes and across races and ethnicities, as NHL is increasingly recognized as comprising a diverse group of cancers, each potentially involving unique mechanisms. JF - International Journal of Cancer AU - Cahoon, Elizabeth K AU - Pfeiffer, Ruth M AU - Wheeler, David C AU - Arhancet, Juan AU - Lin, Shih-Wen AU - Alexander, Bruce H AU - Linet, Martha S AU - Freedman, DMichal AD - Radiation Epidemiology Branch, National Cancer Institute, Division of Cancer Epidemiology and Genetics, U.S. Department of Health and Human Services, National Institutes of Health, Bethesda, MD. Y1 - 2015/03// PY - 2015 DA - Mar 2015 SP - E432 EP - E441 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 136 IS - 5 SN - 0020-7136, 0020-7136 KW - Health & Safety Science Abstracts; Immunology Abstracts; Risk Abstracts KW - Risk reduction KW - Non-Hodgkin's lymphoma KW - Leukemia KW - U.V. radiation KW - Risk factors KW - Ultraviolet radiation KW - Lymphocytes T KW - Lymphoma KW - Races KW - Ethnic groups KW - B-cell lymphoma KW - Etiology KW - Data processing KW - Lymphocytes B KW - Population studies KW - Race differences KW - Cancer KW - Health risks KW - USA KW - T-cell lymphoma KW - Chronic lymphatic leukemia KW - H 8000:Radiation Safety/Electrical Safety KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654666065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Relationship+between+ambient+ultraviolet+radiation+and+non-Hodgkin+lymphoma+subtypes%3A+A+U.S.+population-based+study+of+racial+and+ethnic+groups&rft.au=Cahoon%2C+Elizabeth+K%3BPfeiffer%2C+Ruth+M%3BWheeler%2C+David+C%3BArhancet%2C+Juan%3BLin%2C+Shih-Wen%3BAlexander%2C+Bruce+H%3BLinet%2C+Martha+S%3BFreedman%2C+DMichal&rft.aulast=Cahoon&rft.aufirst=Elizabeth&rft.date=2015-03-01&rft.volume=136&rft.issue=5&rft.spage=E432&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.29237 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Etiology; B-cell lymphoma; Data processing; Lymphocytes B; Population studies; Race differences; Cancer; Leukemia; U.V. radiation; Risk factors; Lymphocytes T; T-cell lymphoma; Chronic lymphatic leukemia; Ethnic groups; Races; Non-Hodgkin's lymphoma; Health risks; Ultraviolet radiation; Risk reduction; Lymphoma; USA DO - http://dx.doi.org/10.1002/ijc.29237 ER - TY - JOUR T1 - Tween-80 and impurity induce anaphylactoid reaction in zebrafish. AN - 1652429972; 25345596 AB - A number of recent reports suspected that Tween-80 in injectable medicines, including traditional Chinese medicine injections could cause life-threatening anaphylactoid reaction, but no sound conclusion was drawn. A drug-induced anaphylactoid reaction is hard to be assayed in vitro and in conventional animal models. In this study, we developed a microplate-based quantitative in vivo zebrafish assay for assessing anaphylactoid reaction and live whole zebrafish mast cell tryptase activity was quantitatively measured at a wavelength of 405 nm using N-benzoyl-dl-arginine p-nitroanilide as a substrate. We assessed 10 batches of Tween-80 solutions from various national and international suppliers and three Tween-80 impurities (ethylene glycol, 2-chloroethanol and hydrogen peroxide) in this model and found that three batches of Tween-80 (nos 2, 20080709 and 20080616) and one Tween-80 impurity, hydrogen peroxide (H2 O2 ), induced anaphylactoid reactions in zebrafish. Furthermore, we found that H2 O2 residue and peroxide value were much higher in Tween-80 samples 2, 20080709 and 20080616. These findings suggest that H2 O2 residue in combination with oxidized fatty acid residues (measured as peroxide value) or more likely the oxidized fatty acid residues in Tween-80 samples, but not Tween-80 itself, may induce anaphylactoid reaction. High-throughput zebrafish tryptase assay developed in this report could be used for assessing safety of Tween-80-containing injectable medicines and potentially for screening novel mast cell-modulating drugs. Copyright © 2014 John Wiley & Sons, Ltd. JF - Journal of applied toxicology : JAT AU - Yang, Rui AU - Lao, Qiao-Cong AU - Yu, Hang-Ping AU - Zhang, Yong AU - Liu, Hong-Cui AU - Luan, Lin AU - Sun, Hui-Min AU - Li, Chun-Qi AD - National Institutes for Food and Drug Control, China Food and Drug Administration (CFDA), No. 2 Tiantan Xili, Dongcheng District, Beijing, 100050, China. Y1 - 2015/03// PY - 2015 DA - March 2015 SP - 295 EP - 301 VL - 35 IS - 3 KW - Drugs, Chinese Herbal KW - 0 KW - Excipients KW - Polysorbates KW - Ethylene Chlorohydrin KW - 753N66IHAN KW - Hydrogen Peroxide KW - BBX060AN9V KW - Tryptases KW - EC 3.4.21.59 KW - Ethylene Glycol KW - FC72KVT52F KW - Index Medicus KW - tryptase KW - zebrafish KW - impurity KW - Tween-80 KW - anaphylactoid reaction KW - Tryptases -- metabolism KW - Hydrogen Peroxide -- toxicity KW - Ethylene Glycol -- chemistry KW - High-Throughput Screening Assays KW - Ethylene Chlorohydrin -- toxicity KW - Animals KW - Intestines -- drug effects KW - Ethylene Chlorohydrin -- chemistry KW - Ethylene Glycol -- toxicity KW - Mast Cells -- drug effects KW - Drugs, Chinese Herbal -- administration & dosage KW - Hydrogen Peroxide -- chemistry KW - Zebrafish -- immunology KW - Excipients -- toxicity KW - Drug Contamination KW - Anaphylaxis -- chemically induced KW - Anaphylaxis -- enzymology KW - Polysorbates -- toxicity KW - Excipients -- chemistry KW - Polysorbates -- chemistry KW - Anaphylaxis -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652429972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Tween-80+and+impurity+induce+anaphylactoid+reaction+in+zebrafish.&rft.au=Yang%2C+Rui%3BLao%2C+Qiao-Cong%3BYu%2C+Hang-Ping%3BZhang%2C+Yong%3BLiu%2C+Hong-Cui%3BLuan%2C+Lin%3BSun%2C+Hui-Min%3BLi%2C+Chun-Qi&rft.aulast=Yang&rft.aufirst=Rui&rft.date=2015-03-01&rft.volume=35&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=1099-1263&rft_id=info:doi/10.1002%2Fjat.3069 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-05 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jat.3069 ER - TY - JOUR T1 - Anesthetic neurotoxicity--clinical implications of animal models. AN - 1659770874; 25714157 AB - Some anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical studies and avoiding nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age. JF - The New England journal of medicine AU - Rappaport, Bob A AU - Suresh, Santhanam AU - Hertz, Sharon AU - Evers, Alex S AU - Orser, Beverley A AD - From the Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD (B.A.R., S.H.); Northwestern University Feinberg School of Medicine, Chicago (S.S.); Washington University School of Medicine, St. Louis (A.S.E.); and the Department of Anesthesia and Physiology, University of Toronto, Toronto (B.A.O.). Y1 - 2015/02/26/ PY - 2015 DA - 2015 Feb 26 SP - 796 EP - 797 VL - 372 IS - 9 KW - Anesthetics KW - 0 KW - Hypnotics and Sedatives KW - Receptors, GABA KW - Receptors, Glutamate KW - Abridged Index Medicus KW - Index Medicus KW - Receptors, GABA -- drug effects KW - Animals KW - Postoperative Complications KW - Receptors, Glutamate -- drug effects KW - Humans KW - Child, Preschool KW - Models, Animal KW - Brain -- drug effects KW - Anesthetics -- adverse effects KW - Practice Guidelines as Topic KW - Surgical Procedures, Operative KW - Hypnotics and Sedatives -- adverse effects KW - Learning Disorders -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1659770874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Anesthetic+neurotoxicity--clinical+implications+of+animal+models.&rft.au=Rappaport%2C+Bob+A%3BSuresh%2C+Santhanam%3BHertz%2C+Sharon%3BEvers%2C+Alex+S%3BOrser%2C+Beverley+A&rft.aulast=Rappaport&rft.aufirst=Bob&rft.date=2015-02-26&rft.volume=372&rft.issue=9&rft.spage=796&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMp1414786 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-11 N1 - Date created - 2015-02-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMp1414786 ER - TY - JOUR T1 - Suppression of CYP2C9 by microRNA hsa-miR-128-3p in human liver cells and association with hepatocellular carcinoma. AN - 1658420585; 25704921 AB - Published studies have identified genetic variants, somatic mutations, and changes in gene expression profiles that are associated with hepatocellular carcinoma (HCC), particularly involving genes that encode drug metabolizing enzymes (DMEs). CYP2C9, one of the most abundant and important DMEs, is involved in the metabolism of many carcinogens and drugs and is down-regulated in HCC. To investigate the molecular mechanisms that control CYP2C9 expression, we applied integrative approaches including in silico, in vitro, and in vivo analyses to elucidate the role of microRNA hsa-miR-128-3p in the regulation of CYP2C9 expression and translation. RNA electrophoresis mobility shift assays demonstrated a direct interaction between hsa-miR-128-3p and its cognate target, the CYP2C9 transcript. Furthermore, the expression of a luciferase reporter gene containing the 3'-UTR of CYP2C9 and the endogenous expression of CYP2C9 were suppressed by transfection of hsa-miR-128-3p. Importantly, chemically-induced up- or down-regulation of hsa-miR-128-3p correlated inversely with the expression of CYP2C9. Finally, an association analysis revealed that the expression of hsa-miR-128-3p is inversely correlated with the expression of CYP2C9 in HCC tumor tissues. Altogether, the study helped to elucidate the mechanism of CYP2C9 regulation by hsa-miR-128-3p, and the inverse association in HCC. JF - Scientific reports AU - Yu, Dianke AU - Green, Bridgett AU - Marrone, April AU - Guo, Yongli AU - Kadlubar, Susan AU - Lin, Dongxin AU - Fuscoe, James AU - Pogribny, Igor AU - Ning, Baitang AD - 1] National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA [2] State Key Laboratory of Molecular Oncology and Department of Etiology &Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 100021. ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Beijing Children's Hospital, Capital Medical University, Beijing, China 100045. ; University of Arkansas for Medical Sciences, AR 72205, USA. ; State Key Laboratory of Molecular Oncology and Department of Etiology &Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China 100021. Y1 - 2015/02/23/ PY - 2015 DA - 2015 Feb 23 SP - 8534 VL - 5 KW - 3' Untranslated Regions KW - 0 KW - MIRN128 microRNA, human KW - MIRN143 microRNA, human KW - MicroRNAs KW - RNA, Messenger KW - Zalcitabine KW - 6L3XT8CB3I KW - Cytochrome P-450 CYP2C9 KW - EC 1.14.13.- KW - Index Medicus KW - Base Sequence KW - Sequence Alignment KW - RNA, Messenger -- metabolism KW - Hep G2 Cells KW - Humans KW - HEK293 Cells KW - Up-Regulation -- drug effects KW - Electrophoretic Mobility Shift Assay KW - RNA, Messenger -- analysis KW - Zalcitabine -- pharmacology KW - Down-Regulation -- drug effects KW - Liver Neoplasms -- pathology KW - MicroRNAs -- metabolism KW - Cytochrome P-450 CYP2C9 -- metabolism KW - Cytochrome P-450 CYP2C9 -- chemistry KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- pathology KW - Liver -- metabolism KW - Cytochrome P-450 CYP2C9 -- genetics KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1658420585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Suppression+of+CYP2C9+by+microRNA+hsa-miR-128-3p+in+human+liver+cells+and+association+with+hepatocellular+carcinoma.&rft.au=Yu%2C+Dianke%3BGreen%2C+Bridgett%3BMarrone%2C+April%3BGuo%2C+Yongli%3BKadlubar%2C+Susan%3BLin%2C+Dongxin%3BFuscoe%2C+James%3BPogribny%2C+Igor%3BNing%2C+Baitang&rft.aulast=Yu&rft.aufirst=Dianke&rft.date=2015-02-23&rft.volume=5&rft.issue=&rft.spage=8534&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep08534 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-02 N1 - Date created - 2015-02-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Biomed Pharmacother. 2010 Jul;64(6):399-408 [20363096] Toxicol Sci. 2010 Dec;118(2):391-403 [20881232] Drug Metab Dispos. 2011 Mar;39(3):528-38 [21149542] Curr Mol Med. 2011 Mar;11(2):93-109 [21342132] Mol Cell Biochem. 2011 Apr;350(1-2):207-13 [21197560] Carcinogenesis. 2012 Jan;33(1):94-100 [22016467] Med Oncol. 2012 Jun;29(2):1242-8 [21264530] Cell Death Differ. 2012 Jun;19(6):1038-48 [22193543] Annu Rev Pharmacol Toxicol. 2013;53:377-400 [23189953] Oncogene. 2013 Mar 28;32(13):1651-9 [22614013] PLoS One. 2013;8(4):e60368 [23637747] Urol Oncol. 2013 Aug;31(6):796-801 [21880514] Exp Cell Res. 2013 Dec 10;319(20):3059-64 [23958464] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2014;32(2):121-58 [24875441] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):3-28 [10667460] Cancer Res. 2001 Mar 1;61(5):2129-37 [11280777] Carcinogenesis. 2001 Aug;22(8):1323-6 [11470765] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15089-94 [11752456] Mol Biol Cell. 2002 Jun;13(6):1929-39 [12058060] Int J Cancer. 2003 Apr 10;104(3):310-7 [12569554] Cancer Res. 2003 Feb 15;63(4):859-64 [12591738] Hepatology. 2004 Feb;39(2):518-27 [14768006] Clin Gastroenterol Hepatol. 2004 Aug;2(8):704-12 [15290664] Mol Cell Proteomics. 2010 Feb;9(2):298-312 [19955085] Cancer Res. 2008 Nov 15;68(22):9125-30 [19010882] J Biomol Screen. 2008 Mar;13(3):194-201 [18270363] Gastroenterology. 2007 Jun;132(7):2557-76 [17570226] Nat Rev Cancer. 2006 Dec;6(12):947-60 [17128211] Nat Rev Cancer. 2006 Nov;6(11):857-66 [17060945] Cancer Res. 2006 Sep 15;66(18):9090-8 [16982751] Hum Mol Genet. 2006 Apr 15;15 Spec No 1:R17-29 [16651366] Mol Carcinog. 1994 Jul;10(3):159-68 [8043197] Int J Oncol. 2005 Sep;27(3):661-7 [16077914] Carcinogenesis. 1999 Jun;20(6):991-5 [10357778] Br J Clin Pharmacol. 1998 Jun;45(6):525-38 [9663807] Hepatology. 1998 Feb;27(2):427-32 [9462641] Pharmacogenetics. 1997 Oct;7(5):401-4 [9352577] Am J Hum Genet. 1997 Feb;60(2):265-71 [9012398] DNA Cell Biol. 1996 Apr;15(4):273-80 [8639263] Pharmacogenetics. 1994 Dec;4(6):285-99 [7704034] Chem Res Toxicol. 1995 Jan-Feb;8(1):136-42 [7703357] RNA. 2004 Oct;10(10):1507-17 [15383676] Gastroenterology. 2004 Nov;127(5 Suppl 1):S72-8 [15508106] Drug Metab Dispos. 2006 Jan;34(1):75-83 [16204462] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep08534 ER - TY - JOUR T1 - Detection of Foodborne Bacterial Pathogens from Individual Filth Flies AN - 1687678668; PQ0001339726 AB - There is unanimous consensus that insects are important vectors of foodborne pathogens. However, linking insects as vectors of the pathogen causing a particular foodborne illness outbreak has been challenging. This is because insects are not being aseptically collected as part of an environmental sampling program during foodborne outbreak investigations and because there is not a standardized method to detect foodborne bacteria from individual insects. To take a step towards solving this problem, we adapted a protocol from a commercially available PCR-based system that detects foodborne pathogens from food and environmental samples, to detect foodborne pathogens from individual flies.Using this standardized protocol, we surveyed 100 wild-caught flies for the presence of Cronobacter spp., Salmonella enterica, and Listeria monocytogenes and demonstrated that it was possible to detect and further isolate these pathogens from the body surface and the alimentary canal of a single fly. Twenty-two percent of the alimentary canals and 8% of the body surfaces from collected wild flies were positive for at least one of the three foodborne pathogens. The prevalence of Cronobacter spp. on either body part of the flies was statistically higher (19%) than the prevalence of S. enterica (7%) and L.monocytogenes (4%). No false positives were observed when detecting S. enterica and L. monocytogenes using this PCR-based system because pure bacterial cultures were obtained from all PCR-positive results. However, pure Cronobacter colonies were not obtained from about 50% of PCR-positive samples, suggesting that the PCR-based detection system for this pathogen cross-reacts with other Enterobacteriaceae present among the highly complex microbiota carried by wild flies. The standardized protocol presented here will allow laboratories to detect bacterial foodborne pathogens from aseptically collected insects, thereby giving public health officials another line of evidence to find out how the food was contaminated when performing foodborne outbreak investigations. JF - Journal of Visualized Experiments AU - Pava-Ripoll, Monica AU - Pearson, Rachel EG AU - Miller, Amy K AU - Ziobro, George C AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration Y1 - 2015/02/13/ PY - 2015 DA - 2015 Feb 13 PB - Journal of Visualized Experiments, 48 Grove St. Somerville, MA 02144 United States IS - 96 KW - Microbiology Abstracts B: Bacteriology KW - Environmental Sciences KW - Issue 96 KW - Synanthropy KW - filth flies KW - Cronobacter KW - Listeria monocytogenes KW - Salmonella KW - Escherichia coli O157:H7 KW - shiga-toxigenic E. coli KW - STEC KW - PCR-based methods KW - foodborne illness KW - foodborne outbreak investigations. KW - Bacteria KW - Food KW - Vectors KW - Pathogens KW - Food contamination KW - Public health KW - Canals KW - Colonies KW - Salmonella enterica KW - Sampling KW - Enterobacteriaceae KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687678668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Visualized+Experiments&rft.atitle=Detection+of+Foodborne+Bacterial+Pathogens+from+Individual+Filth+Flies&rft.au=Pava-Ripoll%2C+Monica%3BPearson%2C+Rachel+EG%3BMiller%2C+Amy+K%3BZiobro%2C+George+C&rft.aulast=Pava-Ripoll&rft.aufirst=Monica&rft.date=2015-02-13&rft.volume=&rft.issue=96&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Visualized+Experiments&rft.issn=1940-087X&rft_id=info:doi/10.3791%2F52372 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Canals; Colonies; Food; Vectors; Sampling; Pathogens; Food contamination; Public health; Listeria monocytogenes; Bacteria; Salmonella enterica; Enterobacteriaceae DO - http://dx.doi.org/10.3791/52372 ER - TY - JOUR T1 - Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1). AN - 1655524162; 25548275 AB - Pregnancy-specific glycoproteins (PSGs) are a family of Ig-like proteins secreted by specialized placental cells. The PSG1 structure is composed of a single Ig variable region-like N-terminal domain and three Ig constant region-like domains termed A1, A2, and B2. Members of the human and murine PSG family have been shown to induce anti-inflammatory cytokines from monocytes and macrophages and to stimulate angiogenesis. We recently showed that recombinant forms of PSG1 (PSG1-Fc and PSG1-His) and PSG1 purified from the serum of pregnant women are associated with the immunoregulatory cytokine TGF-β1 and activated latent TGF-β1. Here, we sought to examine the requirement of specific PSG1 domains in the activation of latent TGF-β1. Plasmon surface resonance studies showed that PSG1 directly bound to the small latent complex and to the latency-associated peptide of TGF-β1 and that this binding was mediated through the B2 domain. Furthermore, the B2 domain alone was sufficient for activating the small latent complex. In separate experiments, we found that the PSG1-mediated induction of TGF-β1 secretion in macrophages was dependent on the N-terminal domain. Mutagenesis analysis revealed that four amino acids (LYHY) of the CC' loop of the N-terminal domain were required for induction of latent TGF-β1 secretion. Together, our results show that two distinct domains of PSG1 are involved in the regulation of TGF-β1 and provide a mechanistic framework for how PSGs modulate the immunoregulatory environment at the maternal-fetal interface for successful pregnancy outcome. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. JF - The Journal of biological chemistry AU - Ballesteros, Angela AU - Mentink-Kane, Margaret M AU - Warren, James AU - Kaplan, Gerardo G AU - Dveksler, Gabriela S AD - From the Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892 and. ; the Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814. ; the Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 gabriela.dveksler@usuhs.edu. Y1 - 2015/02/13/ PY - 2015 DA - 2015 Feb 13 SP - 4422 EP - 4431 VL - 290 IS - 7 KW - Cytokines KW - 0 KW - Pregnancy-Specific beta 1-Glycoproteins KW - RNA, Messenger KW - Transforming Growth Factor beta1 KW - Index Medicus KW - Placenta KW - Surface Plasmon Resonance (SPR) KW - Macrophage KW - Latency-associated Peptide KW - Latent TGF-β1 KW - Heparan Sulfate KW - Pregnancy KW - Real-Time Polymerase Chain Reaction KW - Animals KW - Cytokines -- genetics KW - Humans KW - Cytokines -- metabolism KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Blotting, Western KW - Cells, Cultured KW - Protein Structure, Tertiary KW - Female KW - Immunoenzyme Techniques KW - Protein Conformation KW - Macrophages -- cytology KW - Transforming Growth Factor beta1 -- metabolism KW - Monocytes -- cytology KW - Monocytes -- metabolism KW - Pregnancy-Specific beta 1-Glycoproteins -- genetics KW - Transforming Growth Factor beta1 -- genetics KW - Placenta -- metabolism KW - Placenta -- cytology KW - Pregnancy-Specific beta 1-Glycoproteins -- metabolism KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1655524162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Induction+and+activation+of+latent+transforming+growth+factor-%CE%B21+are+carried+out+by+two+distinct+domains+of+pregnancy-specific+glycoprotein+1+%28PSG1%29.&rft.au=Ballesteros%2C+Angela%3BMentink-Kane%2C+Margaret+M%3BWarren%2C+James%3BKaplan%2C+Gerardo+G%3BDveksler%2C+Gabriela+S&rft.aulast=Ballesteros&rft.aufirst=Angela&rft.date=2015-02-13&rft.volume=290&rft.issue=7&rft.spage=4422&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=1083-351X&rft_id=info:doi/10.1074%2Fjbc.M114.597518 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-08 N1 - Date created - 2015-02-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Leukoc Biol. 2002 Sep;72(3):512-21 [12223519] Am J Reprod Immunol. 2001 Apr;45(4):205-16 [11327547] J Cell Biol. 2004 Jun 7;165(5):723-34 [15184403] Biol Reprod. 2001 Jan;64(1):90-9 [11133662] J Biol Chem. 1997 Jun 27;272(26):16329-34 [9195938] J Exp Med. 2002 Jan 21;195(2):277-82 [11805154] Br J Obstet Gynaecol. 1979 Nov;86(11):888-90 [315792] Biochemistry. 1982 Oct 26;21(22):5523-8 [6983365] J Virol. 1993 Jan;67(1):1-8 [8380065] Anal Biochem. 1994 Feb 1;216(2):276-84 [8179182] Infect Immun. 1995 Jan;63(1):224-8 [7806361] Genomics. 1994 Oct;23(3):669-84 [7851896] J Clin Invest. 1995 Mar;95(3):1363-9 [7883983] J Immunol. 1996 May 1;156(9):3461-8 [8617974] Placenta. 1997 Sep;18(7):491-501 [9290143] J Clin Invest. 1998 Feb 15;101(4):890-8 [9466984] J Biol Chem. 1999 May 7;274(19):13586-93 [10224129] BMC Genomics. 2005;6:4 [15647114] Bioinformatics. 2006 Jan 15;22(2):195-201 [16301204] Annu Rev Immunol. 2006;24:99-146 [16551245] Nat Rev Immunol. 2006 Jun;6(6):433-46 [16724098] J Leukoc Biol. 2008 Jul;84(1):302-10 [18436584] Electrophoresis. 2009 Jun;30 Suppl 1:S162-73 [19517507] Prenat Diagn. 2009 Dec;29(13):1256-61 [19911417] Infect Immun. 2010 Apr;78(4):1789-96 [20123706] J Biol Chem. 2010 May 7;285(19):14806-14 [20207738] J Biol Chem. 2011 Mar 4;286(9):7577-86 [21193412] Nature. 2011 Jun 16;474(7351):343-9 [21677751] Placenta. 2011 Aug;32(8):603-10 [21669460] Eur J Immunol. 2012 Jun;42(6):1573-84 [22678910] Proteins. 2013 Jan;81(1):119-31 [22927229] PLoS One. 2013;8(2):e57491 [23469002] PLoS One. 2013;8(8):e72772 [23936544] Mucosal Immunol. 2014 Mar;7(2):348-58 [23945545] J Cell Biol. 2014 May 12;205(3):409-28 [24821840] Sci Transl Med. 2014 May 21;6(237):237ra65 [24848255] J Reprod Immunol. 2014 Dec;106:89-99 [24933117] J Cell Sci. 2003 Jan 15;116(Pt 2):217-24 [12482908] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1074/jbc.M114.597518 ER - TY - JOUR T1 - Modifying welding process parameters can reduce the neurotoxic potential of manganese-containing welding fumes. AN - 1652422483; 25549921 AB - Welding fumes (WF) are a complex mixture of toxic metals and gases, inhalation of which can lead to adverse health effects among welders. The presence of manganese (Mn) in welding electrodes is cause for concern about the potential development of Parkinson's disease (PD)-like neurological disorder. Consequently, from an occupational safety perspective, there is a critical need to prevent adverse exposures to WF. As the fume generation rate and physicochemical characteristics of welding aerosols are influenced by welding process parameters like voltage, current or shielding gas, we sought to determine if changing such parameters can alter the fume profile and consequently its neurotoxic potential. Specifically, we evaluated the influence of voltage on fume composition and neurotoxic outcome. Rats were exposed by whole-body inhalation (40 mg/m(3); 3h/day × 5 d/week × 2 weeks) to fumes generated by gas-metal arc welding using stainless steel electrodes (GMA-SS) at standard/regular voltage (25 V; RVSS) or high voltage (30 V; HVSS). Fumes generated under these conditions exhibited similar particulate morphology, appearing as chain-like aggregates; however, HVSS fumes comprised of a larger fraction of ultrafine particulates that are generally considered to be more toxic than their fine counterparts. Paradoxically, exposure to HVSS fumes did not elicit dopaminergic neurotoxicity, as monitored by the expression of dopaminergic and PD-related markers. We show that the lack of neurotoxicity is due to reduced solubility of Mn in HVSS fumes. Our findings show promise for process control procedures in developing prevention strategies for Mn-related neurotoxicity during welding; however, it warrants additional investigations to determine if such modifications can be suitably adapted at the workplace to avert or reduce adverse neurological risks. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Sriram, Krishnan AU - Lin, Gary X AU - Jefferson, Amy M AU - Stone, Samuel AU - Afshari, Aliakbar AU - Keane, Michael J AU - McKinney, Walter AU - Jackson, Mark AU - Chen, Bean T AU - Schwegler-Berry, Diane AU - Cumpston, Amy AU - Cumpston, Jared L AU - Roberts, Jenny R AU - Frazer, David G AU - Antonini, James M AD - Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Electronic address: kos4@cdc.gov. ; Health Effects Laboratory Division, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2015/02/03/ PY - 2015 DA - 2015 Feb 03 SP - 168 EP - 178 VL - 328 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Manganese KW - 42Z2K6ZL8P KW - Index Medicus KW - Parkinson’s disease KW - Prevention KW - Parkinsonism KW - Neurotoxicity KW - Welding KW - Animals KW - Solubility KW - Dopaminergic Neurons -- drug effects KW - Body Burden KW - Humans KW - Particle Size KW - Dopaminergic Neurons -- metabolism KW - Risk Assessment KW - Equipment Design KW - Rats, Sprague-Dawley KW - Gene Expression Regulation -- drug effects KW - Time Factors KW - Male KW - Welding -- methods KW - Brain -- drug effects KW - Brain -- metabolism KW - Air Pollutants, Occupational -- toxicity KW - Welding -- instrumentation KW - Air Pollutants, Occupational -- chemistry KW - Manganese Poisoning -- genetics KW - Manganese Poisoning -- metabolism KW - Parkinson Disease, Secondary -- metabolism KW - Inhalation Exposure -- prevention & control KW - Manganese Poisoning -- prevention & control KW - Manganese -- chemistry KW - Parkinson Disease, Secondary -- prevention & control KW - Manganese Poisoning -- etiology KW - Parkinson Disease, Secondary -- genetics KW - Parkinson Disease, Secondary -- etiology KW - Inhalation Exposure -- adverse effects KW - Manganese -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652422483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Modifying+welding+process+parameters+can+reduce+the+neurotoxic+potential+of+manganese-containing+welding+fumes.&rft.au=Sriram%2C+Krishnan%3BLin%2C+Gary+X%3BJefferson%2C+Amy+M%3BStone%2C+Samuel%3BAfshari%2C+Aliakbar%3BKeane%2C+Michael+J%3BMcKinney%2C+Walter%3BJackson%2C+Mark%3BChen%2C+Bean+T%3BSchwegler-Berry%2C+Diane%3BCumpston%2C+Amy%3BCumpston%2C+Jared+L%3BRoberts%2C+Jenny+R%3BFrazer%2C+David+G%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2015-02-03&rft.volume=328&rft.issue=&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2014.12.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-25 N1 - Date created - 2015-01-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Neurology. 2001 Jan 9;56(1):8-13 [11148228] N Engl J Med. 2000 May 25;342(21):1560-7 [10824074] Ann Occup Hyg. 2001 Apr;45(3):187-92 [11295141] FASEB J. 2002 Sep;16(11):1474-6 [12205053] J Toxicol Environ Health A. 2002 Oct 25;65(20):1531-43 [12396867] Science. 2003 Jan 10;299(5604):256-9 [12446870] Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8 [12666096] Brain. 2003 Jun;126(Pt 6):1271-8 [12764050] Ann Neurol. 2004 Jan;55(1):113-8 [14705119] Parkinsonism Relat Disord. 2004 May;10 Suppl 1:S3-7 [15109580] Ind Health. 2004 Apr;42(2):111-5 [15128159] Acta Neuropathol. 2004 Jun;107(6):489-96 [14991385] Inhal Toxicol. 2004 Jun;16(6-7):437-45 [15204759] Occup Environ Med. 2007 Mar;64(3):167-77 [17018581] Neurotoxicology. 2007 Mar;28(2):298-311 [17169432] PLoS One. 2007;2(9):e843 [17786214] J Occup Environ Hyg. 2007 Dec;4(12):903-12 [17957560] Neurosci Lett. 2010 Apr 5;473(2):146-50 [20178828] Arch Toxicol. 2010 Jul;84(7):521-40 [20224926] FASEB J. 2010 Dec;24(12):4989-5002 [20798247] J Environ Monit. 2010 May;12(5):1133-40 [21491680] Nanotoxicology. 2011 Dec;5(4):700-10 [21281223] Biochim Biophys Acta. 1976 Aug 24;444(1):1-10 [60137] Ann Occup Hyg. 1982;25(4):431-8 [7165223] Am J Respir Cell Mol Biol. 1992 Feb;6(2):235-43 [1540387] Br J Ind Med. 1993 Jun;50(6):510-3 [8329316] Trends Neurosci. 1996 Aug;19(8):312-8 [8843599] Ann ICRP. 1994;24(1-3):1-482 [7726471] Neurosci Lett. 1994 Jan 3;165(1-2):208-10 [8015728] Brain Res. 1997 Feb 21;749(1):44-52 [9070626] Nature. 1997 Jul 31;388(6641):482-8 [9242408] Nature. 1998 Apr 9;392(6676):605-8 [9560156] Hum Mol Genet. 1999 Apr;8(4):567-74 [10072423] Prog Neurobiol. 1999 Apr;57(6):563-81 [10221782] Mol Med Today. 1999 May;5(5):225-32 [10322315] Am J Respir Crit Care Med. 1999 Jun;159(6):1943-8 [10351943] Neurology. 2005 Jan 25;64(2):230-5 [15668418] Neurology. 2005 Jun 28;64(12):2033-9 [15888601] J Neurochem. 2006 Feb;96(3):706-18 [16405514] J Occup Environ Hyg. 2006 Apr;3(4):194-203; quiz D45 [16531292] FASEB J. 2006 Apr;20(6):670-82 [16581975] Neurotoxicology. 2006 May;27(3):315-26 [16343629] Environ Health Perspect. 2006 Aug;114(8):1172-8 [16882521] Neurotoxicology. 1999 Dec;20(6):901-7 [10693971] Toxicol Appl Pharmacol. 2001 Jan 15;170(2):79-87 [11162771] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2014.12.015 ER - TY - JOUR T1 - Methods of dark signal determination for CCD array spectroradiometers used in solar UVR measurements AN - 1827887908; PQ0003669170 AB - The methods of the dark signal determination by direct contemporaneous measurements using a light spectrum and modelling of the dark signal based on the dark signal characterisation data were discussed. These techniques were tested with two charge-couple detectors (CCD) array spectroradiometers used in solar UVR measurements. The sensitivity of both instruments was significantly reduced when shutters were used; the measured signal varied by up to 12% depending on the orientation of the shutter. The shutters should be permanently attached to the SSR, so that the orientation cannot be changed to prevent an increase in uncertainty. The method of using blind pixels from the optically inactive part of the CCD array in a light spectrum could be used to derive the dark signal with some limitations for integration times <10 s for the QE65000. An alternative method of deriving the dark signal from light measurements using out-of-range pixels has been proved impossible due to out-of-range stray light in both instruments. The dark signal was characterised for the range of integration times and ambient temperatures of 15-35[degrees]C. Based on these data, the model of the dark signal was developed so that a single value of the dark signal can be subtracted over the whole spectral range if the instrument temperature is known. JF - Radiation Protection Dosimetry AU - Baczynska, K A AU - Khazova, M AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxfordshire OX11 0RQ, UK, katarzyna.baczynska@phe.gov.uk Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 387 EP - 393 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 163 IS - 3 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Sensitivity KW - Radiation KW - Dosimetry KW - Temperature KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827887908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Methods+of+dark+signal+determination+for+CCD+array+spectroradiometers+used+in+solar+UVR+measurements&rft.au=Baczynska%2C+K+A%3BKhazova%2C+M&rft.aulast=Baczynska&rft.aufirst=K&rft.date=2015-02-01&rft.volume=163&rft.issue=3&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncu191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-26 N1 - SubjectsTermNotLitGenreText - Sensitivity; Radiation; Dosimetry; Temperature DO - http://dx.doi.org/10.1093/rpd/ncu191 ER - TY - RPRT T1 - Family Strengthening Research: FY2014. OPRE Report 2015-22 AN - 1773221794; ED558538 AB - This report provides detailed summaries of major research investments by OPRE's Division of Family Strengthening (DFS) along with brief overviews of past projects. The featured projects cover topics that include strengthening relationships within families, supporting fatherhood, nurturing children through their families, reducing teen pregnancy, supporting youth in their transition to adulthood, and preventing family violence. The report also describes DFS's investments in activities to disseminate rigorous research on family strengthening topics to a diverse range of stakeholders including federal and state policy-makers, program administrators, researchers, and intermediary organizations. This report covers OPRE-funded projects through Fiscal Year 2014. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 25 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Early Parenthood KW - Home Visits KW - Research Projects KW - Family Relationship KW - Youth Programs KW - Fathers KW - American Indians KW - Prevention KW - Child Rearing KW - Parent Child Relationship KW - Family Violence KW - Investment KW - Alaska Natives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221794?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Toddlers in Early Head Start: A Portrait of 2-Year-Olds, Their Families, and the Programs Serving Them. Volume 1: Age 2 Report. OPRE Report 2015-10 AN - 1773221697; ED558558 AB - The Early Head Start Family and Child Experiences Survey (Baby FACES) is a descriptive study of Early Head Start programs designed to inform policy and practice at both national and local levels. Baby FACES follows two cohorts of children through their time in Early Head Start, starting in 2009, the first wave of data collection. The Newborn Cohort includes 194 pregnant mothers and newborn children; and the-1-year-old Cohort includes 782 children who were approximately 1 year old (ranging from 10 to 15 months) at the outset of the study. This Baby FACES report focuses on the second wave of data collection and the children from the 1-year-old Cohort (who were 2 in 2010), and presents findings on two broad topics: (1) Describing Early Head Start program services and staff qualifications; and (2) Describing child and family outcomes at age 2. This report sets the stage for a final report on 3-year-olds to follow. The next report will include information collected in spring 2011 and 2012, and will include all study children who remain in the program through age 3. The final report on 3-year-olds will focus on understanding and modeling the longitudinal aspects of the data to offer insight into relations among family/child and staff characteristics, service uptake, service quality, program characteristics, and outcomes. [See earlier report, "Head Start Children, Families, and Programs: Present and Past Data from FACES. OPRE Report 2011-33a," at ED539261.] AU - Vogel, Cheri A. AU - Caronongan, Pia AU - Thomas, Jaime AU - Bandel, Eileen AU - Xue, Yange AU - Henke, Juliette AU - Aikens, Nikki AU - Boller, Kimberly AU - Murphy, Lauren Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 164 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Head Start Family and Child Experiences Survey KW - ERIC, Resources in Education (RIE) KW - Preschool Education KW - Early Childhood Education KW - Program Effectiveness KW - Toddlers KW - Language Acquisition KW - Child Caregivers KW - Teacher Attitudes KW - Family Relationship KW - Child Care KW - Outcomes of Education KW - Child Development KW - Disadvantaged Youth KW - Social Development KW - Access to Health Care KW - Preschool Children KW - Teacher Qualifications KW - Program Descriptions KW - Measures (Individuals) KW - Parent Teacher Cooperation KW - Language Skills KW - Teacher Characteristics KW - Mothers KW - Longitudinal Studies KW - Emotional Development KW - Pregnancy KW - Risk KW - Educational Policy KW - Parent Attitudes KW - Educational Quality KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221697?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Characterizing titanium dioxide and zinc oxide nanoparticles in sunscreen spray AN - 1751203541; PQ0002282987 AB - Synopsis Objective Numerous commercial products contain titanium dioxide (TiO sub(2)) and zinc oxide (ZnO) nanoparticles (NPs); however, many of these are not labelled as containing NPs. This study sought to develop an effective means of characterizing TiO sub(2) and ZnO NPs in sunscreen sprays, including the size, shape and composition of the particles as well as their aggregation/agglomeration characteristics. Methods Transmission electron microscopy (TEM) coupled with a window-type microchip K-kit/copper grid and X-ray diffraction (XRD) was used to characterize the oxide NPs. Results TME pre-treatment was performed using two approaches: using a conventional copper grid (requiring dilution) and using a K-kit (not requiring dilution). The use of K-kit in conjunction with XRD makes it possible to obtain direct measurements from samples that have not undergone pre-treatment, which could otherwise alter the nature of the samples, such as the degree of agglomeration. XRD was used to obtain information related to particle size and crystal structure. A strong correlation was observed between XRD and TEM measurements. Conclusion The proposed measurement methods were shown to be highly effective in the characterization of oxide NPs in sunscreen sprays, providing consistent information related to NPs and their interactions in the formulations.Original Abstract: Resume Objectif De nombreux produits commerciaux contiennent des nanoparticules (NP) du dioxyde de titane (TiO2) et de l'oxyde de zinc (ZnO). Toutefois, beaucoup de ces produits ne sont pas etiquetes comme contenant des NP. Cette etude a cherche a developper un moyen efficace de caracteriser les NP de TiO2 et ZnO dans les aerosols de protection solaire, y compris la taille, la forme et la composition des particules ainsi que leurs caracteristiques d'agregation/agglomeration. Methodes La microscopie electronique a transmission (MET) couplee avec une grille cuivre de type a fenetre micropuce K-kit et la diffraction des rayons X (XRD) ont ete utilisees pour caracteriser les NP d'oxyde. Resultats Le pre-traitement TME a ete effectuee en utilisant deux approches: l'utilisation d'une grille de cuivre conventionnel (necessitant une dilution) et en utilisant une K-kit (ne necessitant pas de dilution). L'utilisation de K-kit conjointement avec diffraction des rayons X permet d'obtenir des mesures directes a partir d'echantillons qui n'ont pas subi un pretraitement qui, sinon, pourrait modifier la nature des echantillons, tels que le degre d'agglomeration. DRX a ete utilise pour obtenir des informations relatives a la taille des particules et la structure cristalline. Une forte correlation a ete observee entre les mesures XRD et TEM. Conclusion Les methodes de mesure proposees ont ete presentees pour etre tres efficace dans la caracterisation des NP d'oxyde dans les sprays de protection solaire, et de fournir des informations coherentes liees aux NP et leurs interactions dans les formulations. JF - International Journal of Cosmetic Science AU - Lu, P J AU - Cheng, W L AU - Huang, S C AU - Chen, Y P AU - Chou, H K AU - Cheng, H F AD - Food and Drug Administration, Ministry of Health and Welfare, No.161-2, Kunyang St, Nangang District, Taipei City, 115-61, Taiwan. PY - 2015 SP - 620 EP - 626 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 37 IS - 6 SN - 0142-5463, 0142-5463 KW - Toxicology Abstracts KW - Transmission electron microscopy KW - Cosmetics KW - Copper KW - X-ray diffraction KW - zinc oxide KW - Titanium dioxide KW - microchips KW - Crystal structure KW - Sunscreens KW - oxides KW - nanoparticles KW - Agglomeration KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751203541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cosmetic+Science&rft.atitle=Characterizing+titanium+dioxide+and+zinc+oxide+nanoparticles+in+sunscreen+spray&rft.au=Lu%2C+P+J%3BCheng%2C+W+L%3BHuang%2C+S+C%3BChen%2C+Y+P%3BChou%2C+H+K%3BCheng%2C+H+F&rft.aulast=Lu&rft.aufirst=P&rft.date=2015-02-01&rft.volume=37&rft.issue=6&rft.spage=620&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cosmetic+Science&rft.issn=01425463&rft_id=info:doi/10.1111%2Fics.12239 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Titanium dioxide; zinc oxide; Transmission electron microscopy; microchips; Crystal structure; oxides; Sunscreens; Cosmetics; Copper; X-ray diffraction; nanoparticles; Agglomeration DO - http://dx.doi.org/10.1111/ics.12239 ER - TY - JOUR T1 - Migration Patterns and Characteristics of Sexual Partners Associated with Unprotected Sexual Intercourse Among Hispanic Immigrant and Migrant Women in the United States AN - 1746892144; PQ0002271899 AB - In 2011, Hispanic immigrant women comprised 44 % of HIV diagnoses among Hispanic women in the United States but little is known about factors that may place these women at risk for infection with HIV or sexually transmitted diseases. From March 2005 to February 2007, women were recruited at community-based organizations offering services to immigrant and migrant communities in five U.S. states. We report factors independently associated with unprotected anal and vaginal sex in the past 12 months among Hispanic immigrant and migrant women. Greater work-related mobility was associated with unprotected anal sex, while recency of immigration and prior refusal of HIV testing were associated with women's reports of unprotected vaginal sex. Prior sex with an injection drug user was associated with reports of both unprotected anal and vaginal sex. Findings highlight the need for HIV/STD risk reduction interventions designed specifically for Hispanic immigrant and migrant women. JF - Journal of Immigrant and Minority Health AU - Valverde, Eduardo E AU - Painter, Thomas AU - Heffelfinger, James D AU - Schulden, Jeffrey D AU - Chavez, Pollyanna AU - DiNenno, Elizabeth A AD - Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, USA, Evalverde@cdc.gov PY - 2015 SP - 1826 EP - 1833 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 6 SN - 1557-1912, 1557-1912 KW - Risk Abstracts KW - Mobility KW - Immigrants KW - Intervention KW - Risk reduction KW - Anal sex KW - Drug abuse KW - Infection KW - Sexual behavior KW - USA KW - Human immunodeficiency virus KW - Risk factors KW - Females KW - Sexually transmitted diseases KW - Migrants KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746892144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Migration+Patterns+and+Characteristics+of+Sexual+Partners+Associated+with+Unprotected+Sexual+Intercourse+Among+Hispanic+Immigrant+and+Migrant+Women+in+the+United+States&rft.au=Valverde%2C+Eduardo+E%3BPainter%2C+Thomas%3BHeffelfinger%2C+James+D%3BSchulden%2C+Jeffrey+D%3BChavez%2C+Pollyanna%3BDiNenno%2C+Elizabeth+A&rft.aulast=Valverde&rft.aufirst=Eduardo&rft.date=2015-02-01&rft.volume=17&rft.issue=6&rft.spage=1826&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-014-0132-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 35 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Mobility; Immigrants; Intervention; Anal sex; Risk reduction; Infection; Drug abuse; Sexual behavior; Human immunodeficiency virus; Risk factors; Females; Ethnic groups; Migrants; Sexually transmitted diseases; USA DO - http://dx.doi.org/10.1007/s10903-014-0132-6 ER - TY - JOUR T1 - Educational attainment and life expectancy: A perspective from the NIH Office of Behavioral and Social Sciences Research AN - 1738477075; 201539221 AB - The NIH Office of Behavioral and Social Sciences Research (OBSSR) furthers the mission of the NIH by stimulating behavioral and social sciences research throughout NIH and integrating these areas of research more fully into the NIH health research enterprise, thereby improving our understanding, treatment, and prevention of disease. OBSSR accomplishes this mission through several strategic priorities: (1) supporting the next generation of basic behavioral and social sciences research, (2) facilitating interdisciplinary research, (3) promoting a multi-level systems perspective of health and behavior, and (4) encouraging a problem-focused perspective on population health. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - Spittel, Michael L AU - Riley, William T AU - Kaplan, Robert M AD - Office of Behavioral and Social Sciences Research (OBSSR/NIH), US Department of Health and Human Services, USA Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 203 EP - 205 PB - Elsevier Science, Amsterdam The Netherlands VL - 127 SN - 0277-9536, 0277-9536 KW - NIH BSSR Education and health Program KW - Prevention KW - Health Research KW - Social Science Research KW - Health Behavior KW - Interdisciplinary Approach KW - Educational Attainment KW - Diseases KW - Longevity KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738477075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Educational+attainment+and+life+expectancy%3A+A+perspective+from+the+NIH+Office+of+Behavioral+and+Social+Sciences+Research&rft.au=Spittel%2C+Michael+L%3BRiley%2C+William+T%3BKaplan%2C+Robert+M&rft.aulast=Spittel&rft.aufirst=Michael&rft.date=2015-02-01&rft.volume=127&rft.issue=&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.11.017 LA - English DB - Sociological Abstracts N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Social Science Research; Health Behavior; Diseases; Longevity; Health Research; Educational Attainment; Interdisciplinary Approach; Prevention DO - http://dx.doi.org/10.1016/j.socscimed.2014.11.017 ER - TY - JOUR T1 - NIOSH national survey of long-haul truck drivers: Injury and safety AN - 1735923372; PQ0002291592 AB - Approximately 1,701,500 people were employed as heavy and tractor-trailer truck drivers in the United States in 2012. The majority of them were long-haul truck drivers (LHTDs). There are limited data on occupational injury and safety in LHTDs, which prompted a targeted national survey. The National Institute of Occupational Safety and Health conducted a nationally representative survey of 1265 LHTDs at 32 truck stops across the contiguous United States in 2010. Data were collected on truck crashes, near misses, moving violations, work-related injuries, work environment, safety climate, driver training, job satisfaction, and driving behaviors. Results suggested that an estimated 2.6% of LHTDs reported a truck crash in 2010, 35% reported at least one crash while working as an LHTD, 24% reported at least one near miss in the previous 7 days, 17% reported at least one moving violation ticket and 4.7% reported a non-crash injury involving days away from work in the previous 12 months. The majority (68%) of non-crash injuries among company drivers were not reported to employers. An estimate of 73% of LHTDs (16% often and 58% sometimes) perceived their delivery schedules unrealistically tight; 24% often continued driving despite fatigue, bad weather, or heavy traffic because they needed to deliver or pick up a load at a given time; 4.5% often drove 10miles per hours or more over the speed limit; 6.0% never wore a seatbelt; 36% were often frustrated by other drivers on the road; 35% often had to wait for access to a loading dock; 37% reported being noncompliant with hours-of-service rules (10% often and 27% sometimes); 38% of LHTDs perceived their entry-level training inadequate; and 15% did not feel that safety of workers was a high priority with their management. This survey brings to light a number of important safety issues for further research and interventions, e.g., high prevalence of truck crashes, injury underreporting, unrealistically tight delivery schedules, noncompliance with hours-of-service rules, and inadequate entry-level training. JF - Accident Analysis & Prevention AU - Chen, Guang X AU - Sieber, WKarl AU - Lincoln, Jennifer E AU - Birdsey, Jan AU - Hitchcock, Edward M AU - Nakata, Akinori AU - Robinson, Cynthia F AU - Collins, James W AU - Sweeney, Marie H AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Safety Research, Morgantown, WV, United States PY - 2015 SP - 66 EP - 72 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 85 SN - 0001-4575, 0001-4575 KW - Health & Safety Science Abstracts KW - Long-haul truck drivers KW - Truck driver safety KW - Truck driver injury KW - Risk factor KW - Survey KW - Hours of service KW - Weather KW - Injuries KW - Training KW - Motor vehicles KW - Occupational safety KW - Safety KW - Intervention KW - Traffic KW - USA KW - Accidents KW - Traffic management KW - Driving ability KW - Perception KW - Trucks KW - Traffic safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735923372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accident+Analysis+%26+Prevention&rft.atitle=NIOSH+national+survey+of+long-haul+truck+drivers%3A+Injury+and+safety&rft.au=Chen%2C+Guang+X%3BSieber%2C+WKarl%3BLincoln%2C+Jennifer+E%3BBirdsey%2C+Jan%3BHitchcock%2C+Edward+M%3BNakata%2C+Akinori%3BRobinson%2C+Cynthia+F%3BCollins%2C+James+W%3BSweeney%2C+Marie+H&rft.aulast=Chen&rft.aufirst=Guang&rft.date=2015-02-01&rft.volume=85&rft.issue=&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Accident+Analysis+%26+Prevention&rft.issn=00014575&rft_id=info:doi/10.1016%2Fj.aap.2015.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Weather; Injuries; Training; Motor vehicles; Safety; Occupational safety; Intervention; Traffic; Accidents; Driving ability; Traffic management; Perception; Trucks; Traffic safety; USA DO - http://dx.doi.org/10.1016/j.aap.2015.09.001 ER - TY - JOUR T1 - Live Attenuated and Inactivated Influenza Vaccines in Children AN - 1687673913; PQ0001568798 AB - Background. Live attenuated influenza vaccine (LAIV) and inactivated influenza vaccine (IIV) are available for children. Local and systemic immunity induced by LAIV followed a month later by LAIV and IIV followed by LAIV were investigated with virus recovery after LAIV doses as surrogates for protection against influenza on natural exposure. Methods. Fifteen children received IIV followed by LAIV, 13 an initial dose of LAIV, and 11 a second dose of LAIV. The studies were done during autumn 2009 and autumn 2010 with the same seasonal vaccine (A/California/07/09 [H1N1], A/Perth/16/09 [H3N2], B/Brisbane/60/08). Results. Twenty-eight of 39 possible influenza viral strains were recovered after the initial dose of LAIV. When LAIV followed IIV, 21 of 45 viral strains were identified. When compared to primary LAIV infection, the decreased frequency of shedding with the IIV-LAIV schedule was significant (P = .023). With LAIV-LAIV, the fewest viral strains were recovered (3/33)-numbers significantly lower (P < .001) than shedding after initial LAIV and after IIV-LAIV (P < .001). Serum hemagglutination inhibition antibody responses were more frequent after IIV than LAIV (P = .02). In contrast, more mucosal immunoglobulin A responses were seen with LAIV. Conclusions. LAIV priming induces greater inhibition of virus recovery on LAIV challenge than IIV priming. The correlate(s) of protection are the subject of ongoing analysis. JF - Journal of Infectious Diseases AU - Ilyushina, Natalia A AU - Haynes, Brenda C AU - Hoen, Anne G AU - Khalenkov, Alexey M AU - Housman, Molly L AU - Brown, Eric P AU - Ackerman, Margaret E AU - Treanor, John J AU - Luke, Catherine J AU - Subbarao, Kanta AU - Wright, Peter F AD - Department of Pediatrics; Food and Drug Administration Center for Drug Evaluation and Research, Bethesda, Maryland, peter.f.wright@hitchcock.org Y1 - 2015/02/01/ PY - 2015 DA - 2015 Feb 01 SP - 352 EP - 360 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 211 IS - 3 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - influenza KW - vaccines KW - children KW - Hemagglutination inhibition KW - Mucosa KW - Immunity KW - Children KW - Infection KW - Influenza KW - Immunoglobulin A KW - Sulfur dioxide KW - Infectious diseases KW - INE, USA, California KW - Australia, Western Australia, Perth KW - Vaccines KW - Seasonal variations KW - Australia, Queensland, Brisbane KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687673913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Live+Attenuated+and+Inactivated+Influenza+Vaccines+in+Children&rft.au=Ilyushina%2C+Natalia+A%3BHaynes%2C+Brenda+C%3BHoen%2C+Anne+G%3BKhalenkov%2C+Alexey+M%3BHousman%2C+Molly+L%3BBrown%2C+Eric+P%3BAckerman%2C+Margaret+E%3BTreanor%2C+John+J%3BLuke%2C+Catherine+J%3BSubbarao%2C+Kanta%3BWright%2C+Peter+F&rft.aulast=Ilyushina&rft.aufirst=Natalia&rft.date=2015-02-01&rft.volume=211&rft.issue=3&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu458 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Influenza; Immunoglobulin A; Hemagglutination inhibition; Mucosa; Immunity; Vaccines; Infection; Children; Sulfur dioxide; Infectious diseases; Seasonal variations; INE, USA, California; Australia, Western Australia, Perth; Australia, Queensland, Brisbane DO - http://dx.doi.org/10.1093/infdis/jiu458 ER - TY - JOUR T1 - APPLICATION OF AN INFORMATICS-BASED DECISION-MAKING FRAMEWORK AND PROCESS TO THE ASSESSMENT OF RADIATION SAFETY IN NANOTECHNOLOGY AN - 1676360621; PQ0001237868 AB - The National Council on Radiation Protection and Measurements (NCRP) established NCRP Scientific Committee 2-6 to develop a report on the current state of knowledge and guidance for radiation safety programs involved with nanotechnology. Nanotechnology is the understanding and control of matter at the nanoscale, at dimensions between ~1 and 100 nm, where unique phenomena enable novel applications. While the full report is in preparation, this paper presents and applies an informatics-based decision-making framework and process through which the radiation protection community can anticipate that nano-enabled applications, processes, nanomaterials, and nanoparticles are likely to become present or are already present in radiation-related activities; recognize specific situations where environmental and worker safety, health, well-being, and productivity may be affected by nano-related activities; evaluate how radiation protection practices may need to be altered to improve protection; control information, interpretations, assumptions, and conclusions to implement scientifically sound decisions and actions; and confirm that desired protection outcomes have been achieved. This generally applicable framework and supporting process can be continuously applied to achieve health and safety at the convergence of nanotechnology and radiation-related activities. JF - Health Physics AU - Hoover, Mark D AU - Myers, David S AU - Cash, Leigh J AU - Guilmette, Raymond A AU - Kreyling, Wolfgang G AU - Oberdorster, Gunter AU - Smith, Rachel AU - Cassata, James R AU - Boecker, Bruce B AU - Grissom, Michael P AD - National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, mhoover1@cdc.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 179 EP - 194 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 108 IS - 2 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts KW - National Council on Radiation Protection and Measurements KW - occupational safety KW - radiation protection KW - risk analysis KW - Radiation KW - Committees KW - Safety KW - Occupational safety KW - Councils KW - Nanotechnology KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676360621?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=APPLICATION+OF+AN+INFORMATICS-BASED+DECISION-MAKING+FRAMEWORK+AND+PROCESS+TO+THE+ASSESSMENT+OF+RADIATION+SAFETY+IN+NANOTECHNOLOGY&rft.au=Hoover%2C+Mark+D%3BMyers%2C+David+S%3BCash%2C+Leigh+J%3BGuilmette%2C+Raymond+A%3BKreyling%2C+Wolfgang+G%3BOberdorster%2C+Gunter%3BSmith%2C+Rachel%3BCassata%2C+James+R%3BBoecker%2C+Bruce+B%3BGrissom%2C+Michael+P&rft.aulast=Hoover&rft.aufirst=Mark&rft.date=2015-02-01&rft.volume=108&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0000000000000250 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Radiation; Committees; Occupational safety; Safety; Councils; Nanotechnology DO - http://dx.doi.org/10.1097/HP.0000000000000250 ER - TY - JOUR T1 - Adoption of the Good Behaviour Game: An evidence-based intervention for the prevention of behaviour problems AN - 1673613627 AB - The Good Behaviour Game (GBG) has been shown to be effective in preventing childhood disruptive behaviours and their long-term unfavourable health-related outcomes. Like many other evidence-based preventive health programmes, however, its current use in Dutch primary schools is limited, and knowledge of the factors influencing the adoption of the programme is scarce. This study aimed to provide a theory-based description of the GBG adoption process and to examine factors influencing this process in primary schools in Amsterdam. In this mixed-methods observational study, semi-structured face-to-face interviews with decision makers from schools that did (n=11), and did not (n=6), adopt the programme were supplemented with structured telephone interviews with non-adopters (n=39). Based on Rogers' Diffusion Theory, the qualitative data were analysed using a deductive approach. Factors facilitating the adoption of the GBG were specific school needs and problems, formulated in educational rather than health terms, and the visibility of the programme's positive effects. Factors impeding adoption were competing programmes in schools and being unaware of favourable funding opportunities. In contrast to previous studies, 'time investment' did not play an impeding role. Adoption of prevention programmes in schools may benefit from framing dissemination strategies in educational terms, and using self-assessment procedures to reveal specific needs/problems and to create a 'readiness to change'. In addition, adoption may benefit from using active dissemination strategies, including opinion leaders reporting their positive experiences with the programme, and the termination of any ineffective programmes that schools currently use. JF - The Health Education Journal AU - Dijkman, Marieke AM AU - Harting, Janneke AU - van der Wal, Marcel F AD - Public Health Service Amsterdam (GGD), Cluster E&G, Amsterdam, The Netherlands ; Department of Social Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands ; Public Health Service Amsterdam (GGD), Cluster E&G, Amsterdam, The Netherlands Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 168 EP - 182 CY - London PB - SAGE PUBLICATIONS, INC. VL - 74 IS - 2 SN - 0017-8969 KW - Medical Sciences KW - Evidence-based programmes KW - behaviour problems KW - primary schools KW - adoption KW - dissemination KW - Behavioural problems KW - Evidence based KW - Preventive programmes KW - Amsterdam Netherlands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673613627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Health+Education+Journal&rft.atitle=Adoption+of+the+Good+Behaviour+Game%3A+An+evidence-based+intervention+for+the+prevention+of+behaviour+problems&rft.au=Dijkman%2C+Marieke+AM%3BHarting%2C+Janneke%3Bvan+der+Wal%2C+Marcel+F&rft.aulast=Dijkman&rft.aufirst=Marieke&rft.date=2015-02-01&rft.volume=74&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=The+Health+Education+Journal&rft.issn=00178969&rft_id=info:doi/10.1177%2F0017896914522234 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-03-24 N1 - Last updated - 2016-09-08 N1 - SubjectsTermNotLitGenreText - Amsterdam Netherlands DO - http://dx.doi.org/10.1177/0017896914522234 ER - TY - JOUR T1 - Multi-walled carbon nanotube-induced gene expression in vitro: Concordance with in vivo studies AN - 1673380220; PQ0001368303 AB - There is a current interest in reducing the in vivo toxicity testing of nanomaterials in animals by increasing toxicity testing using in vitro cellular assays; however, toxicological results are seldom concordant between in vivo and in vitro models. This study compared global multi-walled carbon nanotube (MWCNT)-induced gene expression from human lung epithelial and microvascular endothelial cells in monoculture and coculture with gene expression from mouse lungs exposed to MWCNT. Using a cutoff of 10% false discovery rate and 1.5 fold change, we determined that there were more concordant genes (gene expression both up- or downregulated in vivo and in vitro) expressed in both cell types in coculture than in monoculture. When reduced to only those genes involved in inflammation and fibrosis, known outcomes of in vivo MWCNT exposure, there were more disease-related concordant genes expressed in coculture than monoculture. Additionally, different cellular signaling pathways are activated in response to MWCNT dependent upon culturing conditions. As coculture gene expression better correlated with in vivo gene expression, we suggest that cellular cocultures may offer enhanced in vitro models for nanoparticle risk assessment and the reduction of in vivo toxicological testing. JF - Toxicology AU - Snyder-Talkington, Brandi N AU - Dong, Chunlin AU - Zhao, Xiangyi AU - Dymacek, Julian AU - Porter, Dale W AU - Wolfarth, Michael G AU - Castranova, Vincent AU - Qian, Yong AU - Guo, Nancy L AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 66 EP - 74 PB - Elsevier B.V., P.O. Box 85 Limerick Ireland VL - 328 SN - 0300-483X, 0300-483X KW - Genetics Abstracts; Toxicology Abstracts KW - Coculture KW - Gene expression KW - In vivo KW - In vitro KW - Correlation KW - Risk assessment KW - Microvasculature KW - Fibrosis KW - Animal models KW - Inflammation KW - Endothelial cells KW - Carbon KW - Lung KW - nanoparticles KW - Toxicity testing KW - nanotechnology KW - Signal transduction KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673380220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Multi-walled+carbon+nanotube-induced+gene+expression+in+vitro%3A+Concordance+with+in+vivo+studies&rft.au=Snyder-Talkington%2C+Brandi+N%3BDong%2C+Chunlin%3BZhao%2C+Xiangyi%3BDymacek%2C+Julian%3BPorter%2C+Dale+W%3BWolfarth%2C+Michael+G%3BCastranova%2C+Vincent%3BQian%2C+Yong%3BGuo%2C+Nancy+L&rft.aulast=Snyder-Talkington&rft.aufirst=Brandi&rft.date=2015-02-01&rft.volume=328&rft.issue=&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2014.12.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Risk assessment; Microvasculature; Fibrosis; Animal models; Inflammation; Gene expression; Endothelial cells; Carbon; Lung; Toxicity testing; nanoparticles; Signal transduction; nanotechnology DO - http://dx.doi.org/10.1016/j.tox.2014.12.012 ER - TY - JOUR T1 - A novel method for the simultaneous determination of 14 sweeteners of regulatory interest using UHPLC-MS/MS AN - 1668270599; PQ0001113953 AB - An improved, efficient, sensitive method for the determination of 14 non-nutritive sweeteners in food products was developed using electrospray ionisation (ESI) ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) in the negative-ion mode. Fourteen sweeteners and three internal standards were separated on a reversed-phase UHPLC column using a simple gradient programme. Analyte quantitation and confirmation were performed with data collection in multiple reaction monitoring (MRM) mode. Limits of detection (LODs) were determined in a representative drink, candy and yogurt sample and ranged from 0.1 to 1.8 ng ml super(-1) (drinks) and from 0.1 to 2.5 ng g super(-1) (candy and yogurt). Repeatability at the limit of quantitation (LOQ) ranged from 1% to 13% relative standard deviation (RSD). Twenty-seven commercially available food products were tested using the optimised method showing that the majority of products contained sweetener concentrations below their assigned maximum usable dose. Recovery studies were performed and accuracy data are presented. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Shah, Romina AU - Farris, Samantha AU - De Jager, Lowri S AU - Begley, Timothy H AD - Food and Drug Administration, Center for Food Safety and Applied Nutrition, College Park, MD, USA Y1 - 2015/02/01/ PY - 2015 DA - 2015 Feb 01 SP - 141 EP - 151 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 2 SN - 1944-0049, 1944-0049 KW - Pollution Abstracts; Risk Abstracts KW - Risk assessment KW - Pollution monitoring KW - Data collection KW - Food additives KW - Mass spectrometry KW - P 9999:GENERAL POLLUTION KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668270599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=A+novel+method+for+the+simultaneous+determination+of+14+sweeteners+of+regulatory+interest+using+UHPLC-MS%2FMS&rft.au=Shah%2C+Romina%3BFarris%2C+Samantha%3BDe+Jager%2C+Lowri+S%3BBegley%2C+Timothy+H&rft.aulast=Shah&rft.aufirst=Romina&rft.date=2015-02-01&rft.volume=32&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2014.994111 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Risk assessment; Pollution monitoring; Food additives; Data collection; Mass spectrometry DO - http://dx.doi.org/10.1080/19440049.2014.994111 ER - TY - JOUR T1 - Occupational exposures associated with severe exacerbation of asthma AN - 1668261708; PQ0001170312 AB - BACKGROUND: The exacerbation of asthma by workplace conditions is common, but little is known about which agents pose a risk. OBJECTIVE: We used data from an existing survey of adults with asthma to identify occupational exposures associated with severe exacerbation of asthma. DESIGN: Questionnaires were completed by 557 working adults with asthma. Severe exacerbation of asthma in the past 12 months was defined as asthma-related hospitalization, or reports of both unplanned asthma care and treatment with a short course of oral corticosteroids. Occupational exposures for the same time period were assessed using an asthma-specific job exposure matrix. We modeled severe exacerbation to yield prevalence ratios (PRs) for exposures while controlling for potential confounders. RESULTS: A total of 164 participants (29%) were positive for severe exacerbation, and 227 (40.8%) were assessed as being exposed to asthma agents at work. Elevated PRs were observed for several specific agents, notably the irritant subcategories of environmental tobacco smoke (PR 1.84, 95%CI 1.34-2.51) among all participants, inorganic dusts (PR 2.53, 95%CI 1.37-4.67) among men, and the low molecular weight subcategory of other highly reactive agents (PR 1.97, 95%CI 1.08-3.60) among women. CONCLUSION: Among working adults with asthma, severe exacerbation was associated with several occupational agents. JF - International Journal of Tuberculosis and Lung Disease AU - Henneberger, P K AU - Liang, X AU - Lillienberg, L AU - Dahlman-Hoglund, A AU - Toren, K AU - Andersson, E AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, MS H2800, Morgantown, WV 26505, USA, pkh0@cdc.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 244 EP - 250 PB - International Union Against Tuberculosis and Lung Disease, 68 bvd Saint-Michel Paris 75006 France VL - 19 IS - 2 SN - 1027-3719, 1027-3719 KW - Risk Abstracts; Health & Safety Science Abstracts KW - work-exacerbated asthma KW - job-exposure matrix KW - occupational epidemiology KW - Risk assessment KW - Corticoids KW - Passive smoking KW - Mycobacterium KW - Lung KW - Asthma KW - Tuberculosis KW - Respiratory diseases KW - Occupational exposure KW - Dust KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668261708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Occupational+exposures+associated+with+severe+exacerbation+of+asthma&rft.au=Henneberger%2C+P+K%3BLiang%2C+X%3BLillienberg%2C+L%3BDahlman-Hoglund%2C+A%3BToren%2C+K%3BAndersson%2C+E&rft.aulast=Henneberger&rft.aufirst=P&rft.date=2015-02-01&rft.volume=19&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.14.0132 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Risk assessment; Corticoids; Passive smoking; Lung; Asthma; Tuberculosis; Respiratory diseases; Dust; Occupational exposure; Mycobacterium DO - http://dx.doi.org/10.5588/ijtld.14.0132 ER - TY - JOUR T1 - Tuberculosis misclassification among resettled refugees in Buffalo, New York, USA AN - 1668259385; PQ0001170310 AB - BACKGROUND: Discordance in the classification of tuberculosis (TB) disease overseas compared to classification in the United States has been observed among immigrant populations. OBJECTIVE: To examine TB misclassification among recently resettled refugees in Buffalo, NY, between 2005 and 2012. METHODS: Retrospective study of refugees resettled to Buffalo from 2005 to 2012 and evaluated at a refugee/community health center. Centers for Disease Control and Prevention (CDC) Division of Global Migration and Quarantine (DGMQ) Class B1-B3 and American Thoracic Society (ATS) Class 2 (LTBI) cases were abstracted. Independent variables were demographics, countries of origin and refugee camp internment, year of resettlement, purified protein derivative induration, and chest X-ray findings, while CDC DGMQ and ATS classification were dependent variables. Independent samples Mest and analysis of variance were performed. RESULTS: Of 284 charts reviewed, 233 (81.2%) were misclassified. Among 101 cases of LTBI (B1/B2) diagnosed outside the United States, 51 (50.5%) were overdiagnosed. Underdiagnoses occurred among 181/182 refugees (99.5%) originally classified as normal overseas. CONCLUSION: These findings suggest that TB misclassification among recent immigrants remains widespread. Screening procedures both before and after resettlement should be better synchronized. Public health implications range from morbidity and costs of unnecessary treatment to the spread of a highly communicable disease. JF - International Journal of Tuberculosis and Lung Disease AU - Evans, T B AU - Mador, M J AU - Glick, M AU - Ahmad, I AD - Department of Social & Preventive Medicine, School of Public Health & Health Professions, State University of New York at Buffalo, Buffalo; Indian Health Service, US Department of Health and Human Services, Fort Washakie Health Center, PO Box 128, Fort Washakie, WY 82514, USA, te2105@columbia.edu Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 231 EP - 236 PB - International Union Against Tuberculosis and Lung Disease, 68 bvd Saint-Michel Paris 75006 France VL - 19 IS - 2 SN - 1027-3719, 1027-3719 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts KW - TB misclassification KW - refugees KW - Buffalo KW - NY KW - LTBI KW - tuberculosis KW - USA, New York, Buffalo KW - Mycobacterium KW - Disease control KW - Chest KW - Refugees KW - Migration KW - Morbidity KW - Public health KW - Demography KW - Classification KW - Discordance KW - Thorax KW - Tuberculosis KW - Cyclic AMP KW - Immigrants KW - Lung diseases KW - USA, New York KW - Prevention KW - Lung KW - Reviews KW - Ionizing radiation KW - Proteins KW - Quarantine KW - Tuberculin KW - H 12000:Epidemiology and Public Health KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668259385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.atitle=Tuberculosis+misclassification+among+resettled+refugees+in+Buffalo%2C+New+York%2C+USA&rft.au=Evans%2C+T+B%3BMador%2C+M+J%3BGlick%2C+M%3BAhmad%2C+I&rft.aulast=Evans&rft.aufirst=T&rft.date=2015-02-01&rft.volume=19&rft.issue=2&rft.spage=231&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Tuberculosis+and+Lung+Disease&rft.issn=10273719&rft_id=info:doi/10.5588%2Fijtld.14.0272 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Cyclic AMP; Lung diseases; Immigrants; Disease control; Chest; Migration; Morbidity; Public health; Demography; Ionizing radiation; Reviews; Discordance; Thorax; Quarantine; Tuberculosis; Tuberculin; Refugees; Prevention; Classification; Lung; Proteins; Mycobacterium; USA, New York, Buffalo; USA, New York DO - http://dx.doi.org/10.5588/ijtld.14.0272 ER - TY - JOUR T1 - PUBLIC HEALTH AND MEDICAL PREPAREDNESS FOR A NUCLEAR DETONATION: THE NUCLEAR INCIDENT MEDICAL ENTERPRISE AN - 1668253928; PQ0001237865 AB - Resilience and the ability to mitigate the consequences of a nuclear incident are enhanced by (1) effective planning, preparation and training; (2) ongoing interaction, formal exercises, and evaluation among the sectors involved; (3) effective and timely response and communication; and (4) continuous improvements based on new science, technology, experience, and ideas. Public health and medical planning require a complex, multi-faceted systematic approach involving federal, state, local, tribal, and territorial governments; private sector organizations; academia; industry; international partners; and individual experts and volunteers. The approach developed by the U.S. Department of Health and Human Services Nuclear Incident Medical Enterprise (NIME) is the result of efforts from government and nongovernment experts. It is a "bottom-up" systematic approach built on the available and emerging science that considers physical infrastructure damage, the spectrum of injuries, a scarce resources setting, the need for decision making in the face of a rapidly evolving situation with limited information early on, timely communication, and the need for tools and just-in-time information for responders who will likely be unfamiliar with radiation medicine and uncertain and overwhelmed in the face of the large number of casualties and the presence of radioactivity. The components of NIME can be used to support planning for, response to, and recovery from the effects of a nuclear incident Recognizing that it is a continuous work-in-progress, the current status of the public health and medical preparedness and response for a nuclear incident is provided. JF - Health Physics AU - Coleman, C Norman AU - Sullivan, Julie M AU - Bader, Judith L AU - Murrain-Hill, Paula AU - Koemer, John F AU - Garrett, Andrew L AU - Weinstock, David M AU - Case, Cullen Jr AU - Hrdina, Chad AU - Adams, Steven A AD - Office of Emergency Management, Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC; Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, ccoleman@mail.nih.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 149 EP - 160 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 108 IS - 2 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts KW - National Council on Radiation Protection and Measurements KW - emergency planning KW - nuclear war KW - radiological terrorism KW - France, Languedoc-Roussillon, Nimes KW - Infrastructure KW - Decision making KW - Communications KW - Radiation KW - Injuries KW - Training KW - Radioactivity KW - Private sector KW - Public health KW - Technology KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668253928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=PUBLIC+HEALTH+AND+MEDICAL+PREPAREDNESS+FOR+A+NUCLEAR+DETONATION%3A+THE+NUCLEAR+INCIDENT+MEDICAL+ENTERPRISE&rft.au=Coleman%2C+C+Norman%3BSullivan%2C+Julie+M%3BBader%2C+Judith+L%3BMurrain-Hill%2C+Paula%3BKoemer%2C+John+F%3BGarrett%2C+Andrew+L%3BWeinstock%2C+David+M%3BCase%2C+Cullen+Jr%3BHrdina%2C+Chad%3BAdams%2C+Steven+A&rft.aulast=Coleman&rft.aufirst=C&rft.date=2015-02-01&rft.volume=108&rft.issue=2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0000000000000249 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Infrastructure; Decision making; Communications; Injuries; Radiation; Training; Radioactivity; Private sector; Technology; Public health; France, Languedoc-Roussillon, Nimes DO - http://dx.doi.org/10.1097/HP.0000000000000249 ER - TY - JOUR T1 - National Survey of US Long-Haul Truck Driver Health and Injury: Health Behaviors AN - 1668247793; PQ0001261243 AB - Objective: To compare selected health behaviors and body mass index (modifiable risk factors) of US long-haul truck drivers to the US working population by sex. Methods: The National Survey of US Long-Haul Truck Driver Health and Injury interviewed a nationally representative sample of long-haul truck drivers (n = 1265) at truck stops. Age-adjusted results were compared with national health surveys. Results: Compared with US workers, drivers had significantly higher body mass index, current cigarette use, and pack-years of smoking; lower prevalence of annual influenza vaccination; and generally lower alcohol consumption. Physical activity level was low for most drivers, and 25% had never had their cholesterol levels tested. Conclusions: Working conditions common to long-haul trucking may create significant barriers to certain healthy behaviors; thus, transportation and health professionals should address the unique work environment when developing interventions for long-haul drivers. JF - Journal of Occupational and Environmental Medicine AU - Birdsey, Jan AU - Sieber, W Karl AU - Chen, Guang X AU - Hitchcock, Edward M AU - Lincoln, Jennifer E AU - Nakata, Akinori AU - Robinson, Cynthia F AU - Sweeney, Marie H AD - National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, MS-R17, Cincinnati, OH 45226; Division of Surveillance, Hazard Evaluations, and Field Studies, JBirdsey@cdc.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 210 EP - 216 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 2 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Alcohol KW - Cigarettes KW - Injuries KW - Physical activity KW - Body mass KW - Intervention KW - Cholesterol KW - Working conditions KW - Influenza KW - Transportation KW - Behavior KW - Risk factors KW - Trucks KW - Vaccines KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668247793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=National+Survey+of+US+Long-Haul+Truck+Driver+Health+and+Injury%3A+Health+Behaviors&rft.au=Birdsey%2C+Jan%3BSieber%2C+W+Karl%3BChen%2C+Guang+X%3BHitchcock%2C+Edward+M%3BLincoln%2C+Jennifer+E%3BNakata%2C+Akinori%3BRobinson%2C+Cynthia+F%3BSweeney%2C+Marie+H&rft.aulast=Birdsey&rft.aufirst=Jan&rft.date=2015-02-01&rft.volume=57&rft.issue=2&rft.spage=210&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000338 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-29 N1 - SubjectsTermNotLitGenreText - Alcohol; Injuries; Cigarettes; Body mass; Physical activity; Intervention; Cholesterol; Working conditions; Influenza; Transportation; Behavior; Risk factors; Trucks; Vaccines DO - http://dx.doi.org/10.1097/JOM.0000000000000338 ER - TY - JOUR T1 - Effects of Maternal and Lactational Exposure to 2-Hydroxy-4-Methoxybenzone on Development and Reproductive Organs in Male and Female Rat Offspring AN - 1664209208; PQ0001179074 AB - BACKGROUND 2-Hydroxy-4-methoxybenzophenone (HMB) is an ultraviolet (UV) absorbing compound used in many cosmetic products as a UV-protecting agent and in plastics for preventing UV-induced photodecomposition. HMB has been detected in over 95% of randomly collected human urine samples from adults and from premature infants, and it may have estrogenic potential. METHODS To determine the effects of maternal and lactational exposure to HMB on development and reproductive organs of offspring, time-mated female Harlan Sprague-Dawley rats were dosed with 0, 1000, 3000, 10,000, 25,000, or 50,000 ppm HMB (seven to eight per group) added to chow from gestation day 6 until weaning on postnatal day (PND) 23. RESULTS AND CONCLUSION Exposure to HMB was associated with reduced body and organ weights in female and male offspring. No significant differences were observed in the number of implantation sites/litter, mean resorptions/litter, % litters with resorptions, number and weights of live fetuses, or sex ratios between the control and HMB dose groups. Normalized anogenital distance in male pups at PND 23 was decreased in the highest dose group. Spermatocyte development was impaired in testes of male offspring in the highest dose group. In females, follicular development was delayed in the highest dose group. However, by evaluating levels of the compound in rat serum, the doses at which adverse events occurred are much higher than usual human exposure levels. Thus, exposure to less than 10,000 ppm HMB does not appear to be associated with adverse effects on the reproductive system in rats JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Nakamura, Noriko AU - Inselman, Amy L AU - White, Gene A AU - Chang, Ching-Wei AU - Trbojevich, Raul A AU - Sephr, Estatira AU - Voris, Kristie L AU - Patton, Ralph E AU - Bryant, Matthew S AU - Harrouk, Wafa AU - McIntyre, Barry S AU - Foster, Paul MD AU - Hansen, Deborah K AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas. Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 35 EP - 51 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 104 IS - 1 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Testes KW - Litter KW - Sex ratio KW - Anogenital KW - Weaning KW - Cosmetics KW - Development KW - Reproductive system KW - Spermatocytes KW - Fetuses KW - U.V. radiation KW - Urine KW - Gestation KW - Congenital defects KW - Progeny KW - Reproductive organs KW - Plastics KW - Side effects KW - Infants KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664209208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=Effects+of+Maternal+and+Lactational+Exposure+to+2-Hydroxy-4-Methoxybenzone+on+Development+and+Reproductive+Organs+in+Male+and+Female+Rat+Offspring&rft.au=Nakamura%2C+Noriko%3BInselman%2C+Amy+L%3BWhite%2C+Gene+A%3BChang%2C+Ching-Wei%3BTrbojevich%2C+Raul+A%3BSephr%2C+Estatira%3BVoris%2C+Kristie+L%3BPatton%2C+Ralph+E%3BBryant%2C+Matthew+S%3BHarrouk%2C+Wafa%3BMcIntyre%2C+Barry+S%3BFoster%2C+Paul+MD%3BHansen%2C+Deborah+K&rft.aulast=Nakamura&rft.aufirst=Noriko&rft.date=2015-02-01&rft.volume=104&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrb.21137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Testes; Litter; Sex ratio; Anogenital; Weaning; Cosmetics; Development; Fetuses; Spermatocytes; Reproductive system; U.V. radiation; Urine; Gestation; Congenital defects; Progeny; Plastics; Reproductive organs; Side effects; Infants DO - http://dx.doi.org/10.1002/bdrb.21137 ER - TY - JOUR T1 - Cerium dioxide nanoparticles protect against oxidative stress induced injury through modulation of TGF- beta signalling AN - 1664207311; PQ0001183913 AB - Cerium dioxide nanoparticles have many applications including use as a diesel fuel additive. Concerns over the increased use of engineered nanoparticles and the potential risks to the public have led many studies to investigate the health impacts after nanomaterial exposure. For CeO sub(2) nanoparticles, some studies report oxidative stress leading to a loss of cell viability, where others report the opposite, observing protective effects against oxidative stress induced injury. Due to a lack of consensus over the precise physiological effects surrounding CeO sub(2) exposure, we set out to investigate how these particles influence oxidative stress induced injury. To model the lung as a primary exposure location we used alveolar type II epithelial cells (A549) incubated with CeO sub(2) nanoparticles, prior to an oxidative stress event using either H sub(2)O sub(2) or Menadione. Nanoparticle exposure protected against oxidant-induced injury but this was not paralleled by a reduction in the oxidative stress markers such as protein carbonylation or expression of EGR1 and NQO1. Using gene expression profiling TGF- beta signalling was identified as a candidate mechanism through which the CeO sub(2) nanoparticles were having their protective effects. Using recombinant transforming growth factor beta 1 (TGF- beta 1) we demonstrate protective effects on oxidant-induced injury paralleled by alterations in TGF- beta pathway related gene expression similar to those observed with CeO sub(2) nanoparticle addition. These results represent an important addition to our understanding of the biological effects of CeO sub(2) nanoparticles and identify TGF- beta signalling as a potential mechanistic regulator for their cyto-protective ability. JF - Toxicology Research AU - Guo, Chang AU - Smith, Rachel AU - Gant, Timothy W AU - Leonard, Martin O AD - Centre for Radiation; Chemical and Environmental Hazards; Public Health England; Oxfordshire OX11 0RQ; UK; +44 (0)12358 25164; , Martin.Leonard@phe.gov.uk Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 464 EP - 475 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 4 IS - 2 SN - 2045-452X, 2045-452X KW - Toxicology Abstracts KW - Transforming growth factor- beta 1 KW - Epithelial cells KW - Injuries KW - Fuels KW - Alveoli KW - Gene expression KW - Hydrogen peroxide KW - Oxidative stress KW - Lung KW - Transforming growth factor- beta KW - Menadione KW - NAD(P)H dehydrogenase (quinone) KW - Diesel KW - EGR-1 protein KW - nanoparticles KW - Signal transduction KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664207311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Research&rft.atitle=Cerium+dioxide+nanoparticles+protect+against+oxidative+stress+induced+injury+through+modulation+of+TGF-+beta+signalling&rft.au=Guo%2C+Chang%3BSmith%2C+Rachel%3BGant%2C+Timothy+W%3BLeonard%2C+Martin+O&rft.aulast=Guo&rft.aufirst=Chang&rft.date=2015-02-01&rft.volume=4&rft.issue=2&rft.spage=464&rft.isbn=&rft.btitle=&rft.title=Toxicology+Research&rft.issn=2045452X&rft_id=info:doi/10.1039%2Fc4tx00210e LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 52 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Transforming growth factor- beta 1; Epithelial cells; Injuries; Fuels; Alveoli; Gene expression; Lung; Oxidative stress; Hydrogen peroxide; Transforming growth factor- beta; Menadione; Diesel; NAD(P)H dehydrogenase (quinone); nanoparticles; EGR-1 protein; Signal transduction DO - http://dx.doi.org/10.1039/c4tx00210e ER - TY - JOUR T1 - Nitrate in drinking water and bladder cancer risk in Spain. AN - 1662003271; 25601732 AB - Nitrate is a widespread contaminant in drinking water and ingested nitrate under conditions resulting in endogenous nitrosation is suspected to be carcinogenic. However, the suggested association between nitrate in drinking water and bladder cancer remains inconsistent. We evaluated the long-term exposure to drinking water nitrate as a risk factor for bladder cancer, considering endogenous nitrosation modifiers and other covariables. We conducted a hospital-based case-control study of bladder cancer in Spain (1998-2001). Residential histories and water consumption information were ascertained through personal interviews. Historical nitrate levels (1940-2000) were estimated in study municipalities based on monitoring records and water source. Residential histories of study subjects were linked with nitrate estimates by year and municipality to calculate individual exposure from age 18 to recruitment. We calculated odds ratios (OR) and 95% confidence intervals (CI) for bladder cancer among 531 cases and 556 controls with reliable interviews and nitrate exposure information covering at least 70% of years from age 18 to interview. Average residential levels ranged from 2.1mg/L to 12.0mg/L among regions. Adjusted OR (95%CI) for average residential levels relative to ≤ 5 mg/L were 1.2 (0.7-2.0) for >5-10mg/L and 1.1 (0.6-1.9) for >10mg/L. The OR for subjects with longest exposure duration (>20 years) to highest levels (>9.5mg/L) was 1.4 (0.9-2.3). Stratification by intake of vitamin C, vitamin E, meat, and gastric ulcer diagnosis did not modify these results. A non-significant negative association was found with waterborne ingested nitrate with an OR of 0.7 (0.4-1.0) for >8 vs. ≤ 4 mg/day. Adjustment for several covariables showed similar results to crude analyses. Bladder cancer risk was inconsistently associated with chronic exposure to drinking water nitrate at levels below the current regulatory limit. Elevated risk is suggested only among subjects with longest exposure duration to the highest levels. No evidence of interaction with endogenous nitrosation modifiers was observed. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Environmental research AU - Espejo-Herrera, Nadia AU - Cantor, Kenneth P AU - Malats, Nuria AU - Silverman, Debra T AU - Tardón, Adonina AU - García-Closas, Reina AU - Serra, Consol AU - Kogevinas, Manolis AU - Villanueva, Cristina M AD - Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. ; Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain. ; Universidad de Oviedo, Oviedo, Spain. ; Hospital Universitario de Canarias, La Laguna, Spain. ; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain; Consorci Hospitalari Parc Taulí, Sabadell, Spain. ; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; National School of Public Health, Athens, Greece. ; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra, Departament de Ciències Experimentals i de la Salut, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. Electronic address: cvillanueva@creal.cat. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 299 EP - 307 VL - 137 KW - Carcinogens KW - 0 KW - Drinking Water KW - Nitrates KW - Water Pollutants, Chemical KW - Index Medicus KW - Nitrate KW - Drinking wáter KW - Case-control study KW - Bladder cáncer KW - Water contaminants KW - Environmental Monitoring KW - Animals KW - Risk Factors KW - Humans KW - Cats KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Spain -- epidemiology KW - Male KW - Female KW - Drinking Water -- analysis KW - Water Pollutants, Chemical -- toxicity KW - Urinary Bladder Neoplasms -- epidemiology KW - Nitrates -- toxicity KW - Environmental Exposure KW - Carcinogens -- toxicity KW - Urinary Bladder Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1662003271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Nitrate+in+drinking+water+and+bladder+cancer+risk+in+Spain.&rft.au=Espejo-Herrera%2C+Nadia%3BCantor%2C+Kenneth+P%3BMalats%2C+Nuria%3BSilverman%2C+Debra+T%3BTard%C3%B3n%2C+Adonina%3BGarc%C3%ADa-Closas%2C+Reina%3BSerra%2C+Consol%3BKogevinas%2C+Manolis%3BVillanueva%2C+Cristina+M&rft.aulast=Espejo-Herrera&rft.aufirst=Nadia&rft.date=2015-02-01&rft.volume=137&rft.issue=&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2014.10.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-04 N1 - Date created - 2015-03-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envres.2014.10.034 ER - TY - JOUR T1 - Analysis of Neisseria gonorrhoeae Azithromycin Susceptibility in the United States by the Gonococcal Isolate Surveillance Project, 2005 to 2013 AN - 1660434829; PQ0001092219 AB - Azithromycin, administered with ceftriaxone, is recommended by the CDC for the treatment of gonorrhea. Many experts have expressed concern about the ease with which Neisseria gonorrhoeae can acquire macrolide resistance. We sought to describe gonococcal azithromycin susceptibility in the United States and to determine whether azithromycin susceptibility has changed over time. We analyzed data from 2005 to 2013 from the Gonococcal Isolate Surveillance Project, a CDC-supported sentinel surveillance network that monitors gonococcal antimicrobial susceptibility. A total of 44,144 N. gonorrhoeae isolates were tested for azithromycin susceptibility by agar dilution methods. The overall azithromycin MIC50 was 0.25 mu g/ml, and the MIC90 was 0.5 mu g/ml. There were no overall temporal trends in geometric means. Isolates from men who had sex with men had significantly higher geometric mean MICs than isolates from men who had sex exclusively with women. The overall prevalence of reduced azithromycin susceptibility (MIC, greater than or equal to 2 mu g/ml) was 0.4% and varied by year from 0.3% (2006 and 2009) to 0.6% (2013). We did not find a clear temporal trend in gonococcal azithromycin MICs in the United States, and the prevalence of reduced azithromycin susceptibility remains low. These findings support the continued use of azithromycin in a combination therapy regimen for gonorrhea. JF - Antimicrobial Agents & Chemotherapy AU - Kirkcaldy, Robert D AU - Soge, Olusegun AU - Papp, John R AU - Hook, Edward W, III AU - Rio, Carlos del AU - Kubin, Grace AU - Weinstock, Hillard S AD - Division of STD Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, Georgia, USA, rkirkcaldy@cdc.gov. Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 998 EP - 1003 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Agar KW - Data processing KW - Azithromycin KW - Gonorrhea KW - Ceftriaxone KW - Minimum inhibitory concentration KW - Neisseria gonorrhoeae KW - Sex KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660434829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Analysis+of+Neisseria+gonorrhoeae+Azithromycin+Susceptibility+in+the+United+States+by+the+Gonococcal+Isolate+Surveillance+Project%2C+2005+to+2013&rft.au=Kirkcaldy%2C+Robert+D%3BSoge%2C+Olusegun%3BPapp%2C+John+R%3BHook%2C+Edward+W%2C+III%3BRio%2C+Carlos+del%3BKubin%2C+Grace%3BWeinstock%2C+Hillard+S&rft.aulast=Kirkcaldy&rft.aufirst=Robert&rft.date=2015-02-01&rft.volume=59&rft.issue=2&rft.spage=998&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.04337-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 41 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Agar; Data processing; Azithromycin; Gonorrhea; Ceftriaxone; Minimum inhibitory concentration; Antimicrobial agents; Sex; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1128/AAC.04337-14 ER - TY - JOUR T1 - Muscular activity of lower limb muscles associated with working on inclined surfaces AN - 1660428171; PQ0001027404 AB - This study investigated the effects of visual cues, muscular fatigue, task performance and experience of working on inclined surfaces on activity of postural muscles in the lower limbs associated with maintaining balance on three inclined surfaces - 0 degree , 14 degree and 26 degree . Normalised electromyographic (NEMG) data were collected in 44 professional roofers bilaterally from the rectus femoris, biceps femoris, tibialii anterior and gastrocnemii medial muscle groups. The 50th and 95th percentile NEMG amplitudes were used as EMG variables. Results showed that inclination angle and task performance caused a significant increase in the NEMG amplitudes of all postural muscles. Visual cues were significantly associated with a decrease in the 95th percentile EMG amplitude for the right gastrocnemius medial and tibialis anterior. Fatigue was related to a significant decrease in the NEMG amplitude for the rectus femoris. Experience of working on inclined surfaces did not have a significant effect on the NEMG amplitude. Practitioner Summary: Increasing angle of the working surface and task performance are two main factors contributing to muscular loading in the lower limb muscles. Input of visual cues while working on inclined surfaces may provide beneficial effects on reducing muscular loading to prevent occupational falls. JF - Ergonomics AU - Lu, Ming-Lun AU - Kincl, Laurel AU - Lowe, Brian AU - Succop, Paul AU - Bhattacharya, Amit AD - Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-24, Cincinnati, OH45226, USA Y1 - 2015/02/01/ PY - 2015 DA - 2015 Feb 01 SP - 278 EP - 290 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 58 IS - 2 SN - 0014-0139, 0014-0139 KW - Health & Safety Science Abstracts KW - EMG KW - postural stability KW - visual cues KW - fatigue KW - inclined surfaces KW - Fatigue KW - Muscles KW - Posture KW - Ergonomics KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660428171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Muscular+activity+of+lower+limb+muscles+associated+with+working+on+inclined+surfaces&rft.au=Lu%2C+Ming-Lun%3BKincl%2C+Laurel%3BLowe%2C+Brian%3BSuccop%2C+Paul%3BBhattacharya%2C+Amit&rft.aulast=Lu&rft.aufirst=Ming-Lun&rft.date=2015-02-01&rft.volume=58&rft.issue=2&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140139.2014.968634 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Fatigue; Muscles; Posture; Ergonomics DO - http://dx.doi.org/10.1080/00140139.2014.968634 ER - TY - JOUR T1 - The MCH Training Program: Developing MCH Leaders that are Equipped for the Changing Health Care Landscape AN - 1660417222; PQ0001064670 AB - This article examines the success of the Maternal and Child Health (MCH) Bureau's MCH Training Program in producing the next generation of MCH leaders, equipped with interdisciplinary, leadership skills necessary for the changing health care landscape. A secondary data analysis of performance measure data (2007-2011) collected through the discretionary grant information system was performed. Grantees were grouped by grant program (n = 10) for this analysis. Outcomes of interest 5 years post-program completion included: (1) the percentage of long-term training program graduates who demonstrate field leadership; (2) the percentage of long-term trainees (LTT) who remain in MCH, work with underserved and/or vulnerable populations, or work in a public health agency/organization; and (3) the percentage of LTT working in an interdisciplinary manner to serve the MCH population. Summary output data on the number of LTT reached was also calculated. The number of LTT participating in the MCH Training Program increased between 2007 and 2011. Over 84 % of LTT demonstrate field leadership 5 years after program completion, while 78.2 % of LTT remain in MCH work and 83 % are working with underserved or vulnerable populations. At 5-years post-program completion, over 75 % of LTT are working in an interdisciplinary manner to serve the MCH population. The MCH Training Program has produced well-positioned leaders. Continued investment in the MCH Training Program is critical to ensure a well-trained pipeline of health professionals equipped to address the special health needs of MCH populations in an evolving health system. JF - Maternal and Child Health Journal AU - Kavanagh, Laura AU - Menser, Michelle AU - Pooler, Jennifer AU - Mathis, Sheryl AU - Ramos, Lauren Raskin AD - Division of Maternal and Child Health Workforce Development, Maternal and Child Health Bureau, Health Resources and Services Administration, Rockville, MD, USA, lkavanagh@hrsa.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 257 EP - 264 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 19 IS - 2 SN - 1092-7875, 1092-7875 KW - Health & Safety Science Abstracts KW - Health care KW - Training KW - Grants KW - Landscape KW - Vulnerability KW - Pipelines KW - Public health KW - Information systems KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660417222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Maternal+and+Child+Health+Journal&rft.atitle=The+MCH+Training+Program%3A+Developing+MCH+Leaders+that+are+Equipped+for+the+Changing+Health+Care+Landscape&rft.au=Kavanagh%2C+Laura%3BMenser%2C+Michelle%3BPooler%2C+Jennifer%3BMathis%2C+Sheryl%3BRamos%2C+Lauren+Raskin&rft.aulast=Kavanagh&rft.aufirst=Laura&rft.date=2015-02-01&rft.volume=19&rft.issue=2&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=Maternal+and+Child+Health+Journal&rft.issn=10927875&rft_id=info:doi/10.1007%2Fs10995-014-1574-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 17 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Health care; Training; Landscape; Grants; Pipelines; Vulnerability; Information systems; Public health DO - http://dx.doi.org/10.1007/s10995-014-1574-0 ER - TY - JOUR T1 - Influenza Virus M2 Protein Ion Channel Activity Helps To Maintain Pandemic 2009 H1N1 Virus Hemagglutinin Fusion Competence during Transport to the Cell Surface AN - 1660413830; PQ0001092582 AB - The influenza virus hemagglutinin (HA) envelope protein mediates virus entry by first binding to cell surface receptors and then fusing viral and endosomal membranes during endocytosis. Cleavage of the HA precursor (HA0) into a surface receptor-binding subunit (HA1) and a fusion-inducing transmembrane subunit (HA2) by host cell enzymes primes HA for fusion competence by repositioning the fusion peptide to the newly created N terminus of HA2. We previously reported that the influenza virus M2 protein enhances pandemic 2009 influenza A virus [(H1N1)pdm09] HA-pseudovirus infectivity, but the mechanism was unclear. In this study, using cell-cell fusion and HA-pseudovirus infectivity assays, we found that the ion channel function of M2 was required for enhancement of HA fusion and HA-pseudovirus infectivity. The M2 activity was needed only during HA biosynthesis, and proteolysis experiments indicated that M2 proton channel activity helped to protect (H1N1)pdm09 HA from premature conformational changes as it traversed low-pH compartments during transport to the cell surface. While M2 has previously been shown to protect avian influenza virus HA proteins of the H5 and H7 subtypes that have polybasic cleavage motifs, this study demonstrates that M2 can protect HA proteins from human H1N1 strains that lack a polybasic cleavage motif. This finding suggests that M2 proton channel activity may play a wider role in preserving HA fusion competence among a variety of HA subtypes, including HA proteins from emerging strains that may have reduced HA stability. IMPORTANCE Influenza virus infects cells when the hemagglutinin (HA) surface protein undergoes irreversible pH-induced conformational changes after the virus is taken into the cell by endocytosis. HA fusion competence is primed when host cell enzymes cleave the HA precursor. The proton channel function of influenza virus M2 protein has previously been shown to protect avian influenza virus HA proteins that contain a polybasic cleavage site from pH-induced conformational changes during biosynthesis, but this effect is less well understood for human influenza virus HA proteins that lack polybasic cleavage sites. Using assays that focus on HA entry and fusion, we found that the M2 protein also protects (H1N1)pdm09 influenza A virus HA from premature conformational changes as it transits low-pH compartments during biosynthesis. This work suggests that M2 may play a wider role in preserving HA function in a variety of influenza virus subtypes that infect humans and may be especially important for HA proteins that are less stable. JF - Journal of Virology AU - Alvarado-Facundo, Esmeralda AU - Gao, Yamei AU - Ribas-Aparicio, Rosa Maria AU - Jimenez-Alberto, Alicia AU - Weiss, Carol D AU - Wang, Wei AD - Division of Viral Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA, wei.wang@fda.hhs.gov. PY - 2015 SP - 1975 EP - 1985 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 89 IS - 4 SN - 0022-538X, 0022-538X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - Proteolysis KW - Biosynthesis KW - Cell surface KW - Membranes KW - Avian influenza virus KW - Channel gating KW - Protons KW - Hemagglutinins KW - Enzymes KW - Cell fusion KW - Influenza KW - Endocytosis KW - Fowl plague KW - pandemics KW - Infectivity KW - Influenza A virus KW - Envelope protein KW - Ion channels KW - Proteins KW - H 2000:Transportation KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660413830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Influenza+Virus+M2+Protein+Ion+Channel+Activity+Helps+To+Maintain+Pandemic+2009+H1N1+Virus+Hemagglutinin+Fusion+Competence+during+Transport+to+the+Cell+Surface&rft.au=Alvarado-Facundo%2C+Esmeralda%3BGao%2C+Yamei%3BRibas-Aparicio%2C+Rosa+Maria%3BJimenez-Alberto%2C+Alicia%3BWeiss%2C+Carol+D%3BWang%2C+Wei&rft.aulast=Alvarado-Facundo&rft.aufirst=Esmeralda&rft.date=2015-02-01&rft.volume=89&rft.issue=4&rft.spage=1975&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/10.1128%2FJVI.03253-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 70 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Proteolysis; Cell surface; Channel gating; Protons; Hemagglutinins; Enzymes; Cell fusion; Fowl plague; Endocytosis; Infectivity; pandemics; Ion channels; Envelope protein; Influenza; Biosynthesis; Membranes; Proteins; Avian influenza virus; Influenza A virus DO - http://dx.doi.org/10.1128/JVI.03253-14 ER - TY - JOUR T1 - Utilization of Host Iron Sources by Corynebacterium diphtheriae: Multiple Hemoglobin-Binding Proteins Are Essential for the Use of Iron from the Hemoglobin-Haptoglobin Complex AN - 1660411790; PQ0001092407 AB - The use of hemin iron by Corynebacterium diphtheriae requires the DtxR- and iron-regulated ABC hemin transporter HmuTUV and the secreted Hb-binding protein HtaA. We recently described two surface anchored proteins, ChtA and ChtC, which also bind hemin and Hb. ChtA and ChtC share structural similarities to HtaA; however, a function for ChtA and ChtC was not determined. In this study, we identified additional host iron sources that are utilized by C. diphtheriae. We show that several C. diphtheriae strains use the hemoglobin-haptoglobin (Hb-Hp) complex as an iron source. We report that an htaA deletion mutant of C. diphtheriae strain 1737 is unable to use the Hb-Hp complex as an iron source, and we further demonstrate that a chtA-chtC double mutant is also unable to use Hb-Hp iron. Single-deletion mutants of chtA or chtC use Hb-Hp iron in a manner similar to that of the wild type. These findings suggest that both HtaA and either ChtA or ChtC are essential for the use of Hb-Hp iron. Enzyme-linked immunosorbent assay (ELISA) studies show that HtaA binds the Hb-Hp complex, and the substitution of a conserved tyrosine (Y361) for alanine in HtaA results in significantly reduced binding. C. diphtheriae was also able to use human serum albumin (HSA) and myoglobin (Mb) but not hemopexin as iron sources. These studies identify a biological function for the ChtA and ChtC proteins and demonstrate that the use of the Hb-Hp complex as an iron source by C. diphtheriae requires multiple iron-regulated surface components. JF - Journal of Bacteriology AU - Allen, Courtni E AU - Schmitt, Michael P Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 553 EP - 562 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 197 IS - 3 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Hemopexin KW - Enzyme-linked immunosorbent assay KW - Deletion mutant KW - Alanine KW - human serum albumin KW - Tyrosine KW - Corynebacterium diphtheriae KW - Hemin KW - myoglobin KW - Iron KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660411790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Utilization+of+Host+Iron+Sources+by+Corynebacterium+diphtheriae%3A+Multiple+Hemoglobin-Binding+Proteins+Are+Essential+for+the+Use+of+Iron+from+the+Hemoglobin-Haptoglobin+Complex&rft.au=Allen%2C+Courtni+E%3BSchmitt%2C+Michael+P&rft.aulast=Allen&rft.aufirst=Courtni&rft.date=2015-02-01&rft.volume=197&rft.issue=3&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.02413-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 37 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Hemopexin; Enzyme-linked immunosorbent assay; Deletion mutant; Alanine; Tyrosine; human serum albumin; myoglobin; Hemin; Iron; Corynebacterium diphtheriae DO - http://dx.doi.org/10.1128/JB.02413-14 ER - TY - JOUR T1 - Metal-Mediated Protein Oxidation: Applications of a Modified ELISA-Based Carbonyl Detection Assay for Complex Proteins AN - 1660411079; PQ0001064395 AB - Purpose: Therapeutic proteins are prone to oxidative modification during manufacturing, processing, and storage that may lead to degradation, aggregation, and immunogenicity. Protein carbonylation is an irreversible oxidative modification and has been identified as a hallmark of severe oxidative stress but not extensively studied for its impact on the stability and activity of therapeutic proteins. Methods: We describe the application of a modified ELISA-based method to quantify global levels of carbonyl modification of complex proteins. We investigated protein oxidation of large protein molecules (transferrin, rabbit IgG, or beta -glucosidase) and complex protein samples (human plasma) that were either stored in different buffer formulations, with varying amounts of divalent iron, or under different storage temperatures to determine the impact of different physicochemical stresses on carbonyl modifications. Results: The modified ELISA allows for sensitive and specific carbonyl quantification with measurements that closely match those determined with the conventional spectrophotometric method. The method was useful for complex protein mixtures such as cell lysates without the need for additional procedures to remove DNA and RNA. Our findings demonstrate significant oxidative modification of each of the proteins stored in commonly used buffers and excipients at 37 degree C, 23 degree C, and 4 degree C. The carbonyl levels were further exacerbated with addition of trace amounts of Fe super(2+). We also measured the extent of protein aggregation under oxidizing conditions. Conclusions: Collectively, our results indicate the importance of better characterizing carbonyl modification of proteins during their storage and use. JF - Pharmaceutical Research AU - Uehara, Hiroshi AU - Rao, VAshutosh AD - Laboratory of Chemistry, Division of Therapeutic Proteins, Office of Biotechnology Products, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 29 Lincoln Drive Bldg 29A, Room 2A-11, Bethesda, Maryland, 20892, USA, ashutosh.rao@fda.hhs.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 691 EP - 701 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 32 IS - 2 SN - 0724-8741, 0724-8741 KW - Toxicology Abstracts KW - Temperature effects KW - Enzyme-linked immunosorbent assay KW - Transferrin KW - RNA KW - Oxidative stress KW - Immunogenicity KW - Immunoglobulin G KW - DNA KW - Spectrophotometry KW - beta -Glucosidase KW - Iron KW - carbonyls KW - Protein interaction KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660411079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmaceutical+Research&rft.atitle=Metal-Mediated+Protein+Oxidation%3A+Applications+of+a+Modified+ELISA-Based+Carbonyl+Detection+Assay+for+Complex+Proteins&rft.au=Uehara%2C+Hiroshi%3BRao%2C+VAshutosh&rft.aulast=Uehara&rft.aufirst=Hiroshi&rft.date=2015-02-01&rft.volume=32&rft.issue=2&rft.spage=691&rft.isbn=&rft.btitle=&rft.title=Pharmaceutical+Research&rft.issn=07248741&rft_id=info:doi/10.1007%2Fs11095-014-1496-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 43 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Temperature effects; Enzyme-linked immunosorbent assay; Transferrin; RNA; Immunogenicity; Oxidative stress; DNA; Immunoglobulin G; Spectrophotometry; beta -Glucosidase; carbonyls; Iron; Protein interaction DO - http://dx.doi.org/10.1007/s11095-014-1496-y ER - TY - JOUR T1 - Changes in prevalence of chronic obstructive pulmonary disease and asthma in the US population and associated risk factors AN - 1660405827; PQ0001016374 AB - Chronic lower airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma, are currently the third leading cause of death in the United States. We aimed to evaluate changes in prevalence of and risk factors for COPD and asthma among the US adult population. We evaluated changes in prevalence of self-reported doctor-diagnosed COPD (i.e. chronic bronchitis and emphysema) and asthma and self-reported respiratory symptoms comparing data from the 1988-1994 and 2007-2010 National Health and Nutrition Examination Surveys. To investigate changes in the severity of each outcome over the two periods, we calculated changes in the proportions of spirometry-based airflow obstruction for each outcome. Prevalence of doctor-diagnosed chronic bronchitis and emphysema decreased significantly mainly among males, while asthma increased only among females. The self-reported disease and the respiratory symptoms were associated with increased prevalence of airflow obstruction for both periods. However, the prevalence of airflow obstruction decreased significantly in the second period among those with shortness of breath and doctor-diagnosed respiratory conditions (chronic bronchitis, emphysema, and asthma). COPD outcomes and asthma were associated with lower education, smoking, underweight and obesity, and occupational dusts and fumes exposure. Chronic lower airway diseases continue to be major public health problems. However, decreased prevalence of doctor-diagnosed chronic bronchitis and emphysema (in males) and decreased prevalence of airflow obstruction in those with respiratory symptoms and doctor-diagnosed respiratory diseases may indicate a declining trend and decrease in disease severity between the two periods. Continued focus on prevention of these diseases through public health interventions is prudent. JF - Chronic Respiratory Disease AU - Halldin, Cara N AU - Doney, Brent C AU - Hnizdo, Eva AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA, Epidemic Intelligence Service Program, Centers for Disease Control and Prevention, Atlanta, GA, USA, challdin@cdc.gov Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 47 EP - 60 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 12 IS - 1 SN - 1479-9723, 1479-9723 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Chronic bronchitis KW - emphysema KW - asthma KW - occupational exposure KW - occupational diseases KW - NHANES KW - Obesity KW - Mortality KW - Intervention KW - Asthma KW - Respiratory diseases KW - Nutrition KW - Dust KW - Chronic obstructive pulmonary disease KW - Public health KW - Health risks KW - USA KW - Prevention KW - Education KW - Risk factors KW - Air flow KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660405827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chronic+Respiratory+Disease&rft.atitle=Changes+in+prevalence+of+chronic+obstructive+pulmonary+disease+and+asthma+in+the+US+population+and+associated+risk+factors&rft.au=Halldin%2C+Cara+N%3BDoney%2C+Brent+C%3BHnizdo%2C+Eva&rft.aulast=Halldin&rft.aufirst=Cara&rft.date=2015-02-01&rft.volume=12&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Chronic+Respiratory+Disease&rft.issn=14799723&rft_id=info:doi/10.1177%2F1479972314562409 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 57 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Mortality; Obesity; Asthma; Intervention; Respiratory diseases; Nutrition; Dust; Public health; Chronic obstructive pulmonary disease; Health risks; Education; Prevention; Risk factors; Air flow; USA DO - http://dx.doi.org/10.1177/1479972314562409 ER - TY - JOUR T1 - Overview of the National Occupational Mortality Surveillance (NOMS) system: Leukemia and acute myocardial infarction risk by industry and occupation in 30 US states 1985-1999, 2003-2004, and 2007 AN - 1660390334; PQ0001048142 AB - Background Cancer and chronic disease are leading causes of death in the US with an estimated cost of $46 billion. Methods We analyzed 11 million cause-specific deaths of US workers age 18-64 years in 30 states during 1985-1999, 2003-2004, and 2007 by occupation, industry, race, gender, and Hispanic origin. Results The highest significantly elevated proportionate leukemia mortality was observed in engineers, protective service, and advertising sales manager occupations and in banks/savings &loans/credit agencies, public safety, and public administration industries. The highest significantly elevated smoking-adjusted acute myocardial infarction mortality was noted in industrial and refractory machinery mechanics, farmers, mining machine operators, and agricultural worker occupations; and wholesale farm supplies, agricultural chemical, synthetic rubber, and agricultural crop industries. Conclusions Significantly elevated risks for acute myocardial infarction and leukemia were observed across several occupations and industries that confirm existing reports and add new information. Interested investigators can access the NOMS website at http://www.cdc.gov/niosh/topics/NOMS/ . Am. J. Ind. Med. 58:123-137, 2015. copyright 2015 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Robinson, Cynthia F AU - Walker, James T AU - Sweeney, Marie H AU - Shen, Rui AU - Calvert, Geoffrey M AU - Schumacher, Pam K AU - Ju, Jun AU - Nowlin, Susan AD - The National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Division of Surveillance, Hazard Evaluation and Field Studies, Cincinnati, Ohio. Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 123 EP - 137 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 2 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - Agriculture KW - Age KW - Farms KW - Crops KW - Workers KW - Leukemia KW - Machinery KW - Ethnic groups KW - Races KW - Mortality KW - Loans KW - Safety KW - Rubber KW - Advertising KW - Agrochemicals KW - Cancer KW - Myocardial infarction KW - Health risks KW - Reviews KW - Gender KW - Mining KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660390334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Overview+of+the+National+Occupational+Mortality+Surveillance+%28NOMS%29+system%3A+Leukemia+and+acute+myocardial+infarction+risk+by+industry+and+occupation+in+30+US+states+1985-1999%2C+2003-2004%2C+and+2007&rft.au=Robinson%2C+Cynthia+F%3BWalker%2C+James+T%3BSweeney%2C+Marie+H%3BShen%2C+Rui%3BCalvert%2C+Geoffrey+M%3BSchumacher%2C+Pam+K%3BJu%2C+Jun%3BNowlin%2C+Susan&rft.aulast=Robinson&rft.aufirst=Cynthia&rft.date=2015-02-01&rft.volume=58&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22408 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Agriculture; Mortality; Age; Farms; Rubber; Myocardial infarction; Crops; Cancer; Leukemia; Workers; Reviews; Mining; Races; Loans; Safety; Advertising; Agrochemicals; Health risks; Machinery; Gender; Ethnic groups DO - http://dx.doi.org/10.1002/ajim.22408 ER - TY - JOUR T1 - New insights into the role of the disordered WIP N-terminal domain revealed by NMR structural characterization AN - 1655677033 AB - WASp-interacting protein (WIP) is an intrinsically disordered 503-residue polypeptide with a key role in actin polymerization in activated T cells. Its interaction with actin is mediated by a pair of conserved actin binding motifs (ABMs) at the WIP N-terminus, a domain that has not been investigated in its unbound form. Here we use NMR to investigate the biophysical behavior of the N-terminal ABM in WIP using protonless 13C'-detected spectroscopy. Secondary chemical shifts, residual dipolar couplings and temperature effects identify residual structure throughout the ABM, which exhibits transient helical and [beta]-strand character for residues 30-42 and 44-62, respectively. These observed structural propensities echo the structure observed in the actin-bound state of the ABM. Furthermore, residues preceding the canonical ABM (17-25) and conserved among WIP-related proteins exhibit transient [beta]-strand character, suggesting that the WIPN interaction epitope extends towards the N-terminal polyproline motif. This suggests a possible role for this region in mediating the WIP interaction with polyproline binders such as profilin. In revealing these features of the WIP ABM this study demonstrates the unique ability of NMR in characterizing unstructured domains and provides necessary information for further investigation of WIP-mediated protein-protein interactions. JF - The FEBS Journal AU - Elazari-Shalom, Hila AU - Shaked, Hadassa AU - Esteban-Martin, Santiago AU - Salvatella, Xavier AU - Barda-Saad, Mira AU - Chill, Jordan H Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 700 EP - 714 CY - Oxford PB - Blackwell Publishing Ltd. VL - 282 IS - 4 SN - 1742464X KW - Biology--Biochemistry KW - Proteins KW - Nuclear magnetic resonance--NMR KW - Polymerization KW - Biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1655677033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apqrl&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+FEBS+Journal&rft.atitle=New+insights+into+the+role+of+the+disordered+WIP+N-terminal+domain+revealed+by+NMR+structural+characterization&rft.au=Elazari-Shalom%2C+Hila%3BShaked%2C+Hadassa%3BEsteban-Martin%2C+Santiago%3BSalvatella%2C+Xavier%3BBarda-Saad%2C+Mira%3BChill%2C+Jordan+H&rft.aulast=Elazari-Shalom&rft.aufirst=Hila&rft.date=2015-02-01&rft.volume=282&rft.issue=4&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=The+FEBS+Journal&rft.issn=1742464X&rft_id=info:doi/10.1111%2Ffebs.13174 LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2015 Federation of European Biochemical Societies N1 - Document feature - References N1 - Last updated - 2015-04-13 DO - http://dx.doi.org/10.1111/febs.13174 ER - TY - JOUR T1 - Long-term stability study of Prussian blue-A quality assessment of water content and cyanide release. AN - 1653130931; 25608705 AB - Prussian blue, ferric hexacyanoferrate is approved for (oral) treatment of internal contamination with radioisotopes of cesium or thallium. Cyanide makes up 35-40% of Prussian blue's molecular composition; thus, cyanide may be released during transit through the digestive tract under physiological pH conditions. The purpose of this study is to assess the long-term stability of Prussian blue drug products and active pharmaceutical ingredients and its impact on cyanide release. The study involves the determination and comparison of the loss in water content and cyanide released from Prussian blue under pH conditions that bracket human physiological exposure. Test samples of active pharmaceutical ingredient and drug product were stored for 10 years at ambient temperatures that mimic warehouse storage conditions. Water loss from Prussian blue was measured using thermogravimetric analysis. An in vitro physiological pH model that brackets gastric exposure and gastrointestinal transit was utilized for cyanide release. Prussian blue was incubated in situ at pH: 1.0, 5.0, and 7.0 @ 37°C for 1-24 h. Cyanide was measured using a validated colorimetric method by UV-Vis spectroscopy. Although the water content (quality attribute) of Prussian blue active pharmaceutical ingredient and drug product decreased by about 10.5% and 13.8%, respectively, since 2003, the cyanide release remained comparable. At pH of 7.0 for 24 h cyanide released from active pharmaceutical ingredient-1 was 21.33 ± 1.76 μg/g in 2004, and 28.45 ± 3.15 μg/g in 2013; cyanide released from drug product-1 was 21.89 ± 0.56 μg/g in 2004, and 27.31 ± 5.78 μg/g in 2013. At gastric pH of 1.0 and upper gastrointestinal pH of 5.0, the data for active pharmaceutical ingredients and drug products were also comparable in 2013. The cyanide release is still pH-dependent and follows the same trend as observed in 2003 with minimum release at pH of 5.0 and maximal release at pH of 1.0. In summary, this is the long-term stability study of Prussian blue which correlates cyanide release to water loss. Cyanide released from Prussian blue was maximum at pH of 1.0 (47.47 μg/g) and minimum at pH of 5.0-7.0 (20.01 μg/g). Based on maximal dose, maximal residence time in stomach and intestine, the maximal cyanide released from Prussian blue is about 1.31 mg, which is far below the minimal lethal dose of cyanide of 50 mg, and therefore does not present a safety concern following long-term storage. JF - Clinical toxicology (Philadelphia, Pa.) AU - Mohammad, A AU - Yang, Y AU - Khan, M A AU - Faustino, P J AD - Food and Drug Administration, Center for Drug Evaluation and Research, Division of Product Quality Research , Silver Spring, MD , USA. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 102 EP - 107 VL - 53 IS - 2 KW - Cyanides KW - 0 KW - Ferrocyanides KW - Water KW - 059QF0KO0R KW - ferric ferrocyanide KW - TLE294X33A KW - Abridged Index Medicus KW - Index Medicus KW - Prussian blue KW - Long-term stability KW - Toxicity KW - Cyanide poisoning KW - Crystallization KW - Drug Stability KW - Hydrogen-Ion Concentration KW - Reference Standards KW - Calibration KW - Quality Control KW - Water -- analysis KW - Cyanides -- analysis KW - Ferrocyanides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1653130931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+toxicology+%28Philadelphia%2C+Pa.%29&rft.atitle=Long-term+stability+study+of+Prussian+blue-A+quality+assessment+of+water+content+and+cyanide+release.&rft.au=Mohammad%2C+A%3BYang%2C+Y%3BKhan%2C+M+A%3BFaustino%2C+P+J&rft.aulast=Mohammad&rft.aufirst=A&rft.date=2015-02-01&rft.volume=53&rft.issue=2&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Clinical+toxicology+%28Philadelphia%2C+Pa.%29&rft.issn=1556-9519&rft_id=info:doi/10.3109%2F15563650.2014.998337 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-06 N1 - Date created - 2015-02-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/15563650.2014.998337 ER - TY - JOUR T1 - More than half of US youth consume seafood and most have blood mercury concentrations below the EPA reference level, 2009-2012. AN - 1652454159; 25644354 AB - Consuming seafood has health benefits, but seafood can also contain methylmercury, a neurotoxicant. Exposure to methylmercury affects children at different stages of brain development, including during adolescence. The objective was to examine seafood consumption and blood mercury concentrations in US youth. In the 2009-2012 NHANES, a cross-sectional nationally representative sample of the US population, seafood consumption in the past 30 d and blood mercury concentrations on the day of examination were collected from 5656 youth aged 1-19 y. Log-linear regression was used to examine the association between frequency of specific seafood consumption and blood mercury concentration, adjusting for race/Hispanic origin, sex, and age. In 2009-2012, 62.4% ± 1.4% (percent ± SE) of youth consumed any seafood in the preceding month; 38.4% ± 1.4% and 48.5% ± 1.5% reported consuming shellfish and fish, respectively. In 2009-2012, the geometric mean blood mercury concentration was 0.50 ± 0.02 μg/L among seafood consumers and 0.27 ± 0.01 μg/L among those who did not consume seafood. Less than 0.5% of youth had blood mercury concentrations ≥5.8 μg/L. In adjusted log-linear regression analysis, no significant associations were observed between frequency of breaded fish or catfish consumption and blood mercury concentrations, but frequency of consuming certain seafood types had significant positive association with blood mercury concentrations: high-mercury fish (swordfish and shark) [exponentiated β coefficient (expβ): 2.40; 95% CI: 1.23, 4.68]; salmon (expβ: 1.41; 95% CI: 1.26, 1.55); tuna (expβ: 1.38; 95% CI: 1.29, 1.45); crabs (expβ: 1.35; 95% CI: 1.17, 1.55); shrimp (expβ: 1.12; 95% CI: 1.05, 1.20), and all other seafood (expβ: 1.23; 95% CI: 1.17, 1.32). Age-stratified log-linear regression analyses produced similar results. Few US youth have blood mercury concentrations ≥5.8 μg/L, although more than half of US youth consumed seafood in the past month. © 2015 American Society for Nutrition. JF - The Journal of nutrition AU - Nielsen, Samara Joy AU - Aoki, Yutaka AU - Kit, Brian K AU - Ogden, Cynthia L AD - Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, CDC, Hyattsville, MD; and wjf7@cdc.gov. ; Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, CDC, Hyattsville, MD; and. ; Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, CDC, Hyattsville, MD; and US Public Health Service, Rockville, MD. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 322 EP - 327 VL - 145 IS - 2 KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - blood mercury KW - shellfish KW - seafood KW - fish KW - youth KW - United States KW - Young Adult KW - United States Environmental Protection Agency KW - Humans KW - Food Contamination -- analysis KW - Child KW - Nutrition Surveys KW - Child, Preschool KW - Risk Assessment KW - Infant KW - Cross-Sectional Studies KW - Adolescent KW - Female KW - Male KW - Nutrition Policy -- legislation & jurisprudence KW - Mercury -- blood KW - Environmental Exposure -- analysis KW - Seafood -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652454159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nutrition&rft.atitle=More+than+half+of+US+youth+consume+seafood+and+most+have+blood+mercury+concentrations+below+the+EPA+reference+level%2C+2009-2012.&rft.au=Nielsen%2C+Samara+Joy%3BAoki%2C+Yutaka%3BKit%2C+Brian+K%3BOgden%2C+Cynthia+L&rft.aulast=Nielsen&rft.aufirst=Samara&rft.date=2015-02-01&rft.volume=145&rft.issue=2&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nutrition&rft.issn=1541-6100&rft_id=info:doi/10.3945%2Fjn.114.203786 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-23 N1 - Date created - 2015-02-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3945/jn.114.203786 ER - TY - JOUR T1 - Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein. AN - 1652444027; 25349334 AB - One endocrine disruption mechanism is through binding to nuclear receptors such as the androgen receptor (AR) and estrogen receptor (ER) in target cells. The concentration of a chemical in serum is important for its entry into the target cells to bind the receptors, which is regulated by the serum proteins. Human sex hormone-binding globulin (SHBG) is the major transport protein in serum that can bind androgens and estrogens and thus change a chemical's availability to enter the target cells. Sequestration of an androgen or estrogen in the serum can alter the chemical elicited AR- and ER-mediated responses. To better understand the chemical-induced endocrine activity, we developed a competitive binding assay using human pregnancy plasma and measured the binding to the human SHBG for 125 structurally diverse chemicals, most of which were known to bind AR and ER. Eighty seven chemicals were able to bind the human SHBG in the assay, whereas 38 chemicals were nonbinders. Binding data for human SHBG are compared with that for rat α-fetoprotein, ER and AR. Knowing the binding profiles between serum and nuclear receptors will improve assessment of a chemical's potential for endocrine disruption. The SHBG binding data reported here represent the largest data set of structurally diverse chemicals tested for human SHBG binding. Utilization of the SHBG binding data with AR and ER binding data could enable better evaluation of endocrine disrupting potential of chemicals through AR- and ER-mediated responses since sequestration in serum could be considered. Published by Oxford University Press on behalf of the Society of Toxicology 2014. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Hong, Huixiao AU - Branham, William S AU - Ng, Hui Wen AU - Moland, Carrie L AU - Dial, Stacey L AU - Fang, Hong AU - Perkins, Roger AU - Sheehan, Daniel AU - Tong, Weida AD - *Division of Bioinformatics and Biostatistics, Division of Systems Biology, Division of Genetic and Molecular Toxicology and Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079 huixiao.hong@fda.hhs.gov. ; *Division of Bioinformatics and Biostatistics, Division of Systems Biology, Division of Genetic and Molecular Toxicology and Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 333 EP - 348 VL - 143 IS - 2 KW - Endocrine Disruptors KW - 0 KW - Ligands KW - Receptors, Androgen KW - Receptors, Estrogen KW - Sex Hormone-Binding Globulin KW - alpha-Fetoproteins KW - Index Medicus KW - sex hormone-binding globulin KW - binding affinity KW - endocrine disruptor KW - androgen receptor KW - alpha-fetoprotein KW - estrogen receptor KW - Models, Molecular KW - Humans KW - Binding, Competitive KW - Protein Binding KW - Structure-Activity Relationship KW - Sex Hormone-Binding Globulin -- chemistry KW - Endocrine Disruptors -- metabolism KW - Receptors, Androgen -- metabolism KW - alpha-Fetoproteins -- chemistry KW - Sex Hormone-Binding Globulin -- metabolism KW - Receptors, Estrogen -- chemistry KW - Receptors, Estrogen -- metabolism KW - Receptors, Androgen -- chemistry KW - alpha-Fetoproteins -- metabolism KW - Endocrine Disruptors -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652444027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Human+sex+hormone-binding+globulin+binding+affinities+of+125+structurally+diverse+chemicals+and+comparison+with+their+binding+to+androgen+receptor%2C+estrogen+receptor%2C+and+%CE%B1-fetoprotein.&rft.au=Hong%2C+Huixiao%3BBranham%2C+William+S%3BNg%2C+Hui+Wen%3BMoland%2C+Carrie+L%3BDial%2C+Stacey+L%3BFang%2C+Hong%3BPerkins%2C+Roger%3BSheehan%2C+Daniel%3BTong%2C+Weida&rft.aulast=Hong&rft.aufirst=Huixiao&rft.date=2015-02-01&rft.volume=143&rft.issue=2&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu231 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-01 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu231 ER - TY - JOUR T1 - Carbon nanotubes induce apoptosis resistance of human lung epithelial cells through FLICE-inhibitory protein. AN - 1652441335; 25412619 AB - Chronic exposure to single-walled carbon nanotubes (SWCNT) has been reported to induce apoptosis resistance of human lung epithelial cells. As resistance to apoptosis is a foundation of neoplastic transformation and cancer development, we evaluated the apoptosis resistance characteristic of the exposed lung cells to understand the pathogenesis mechanism. Passage control and SWCNT-transformed human lung epithelial cells were treated with known inducers of apoptosis via the intrinsic (antimycin A and CDDP) or extrinsic (FasL and TNF-α) pathway and analyzed for apoptosis by DNA fragmentation, annexin-V expression, and caspase activation assays. Whole-genome microarray was performed to aid the analysis of apoptotic gene signaling network. The SWCNT-transformed cells exhibited defective death receptor pathway in association with cellular FLICE-inhibitory protein (c-FLIP) overexpression. Knockdown or chemical inhibition of c-FLIP abrogated the apoptosis resistance of SWCNT-transformed cells. Whole-genome expression signature analysis confirmed these findings. This study is the first to demonstrate carbon nanotube-induced defective death receptor pathway and the role of c-FLIP in the process. Published by Oxford University Press on behalf of the Society of Toxicology 2014. This work is written by US Government employees and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Pongrakhananon, Varisa AU - Luanpitpong, Sudjit AU - Stueckle, Todd A AU - Wang, Liying AU - Nimmannit, Ubonthip AU - Rojanasakul, Yon AD - *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand. ; *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand. ; *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand. ; *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand *Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, Department of Pharmacology and Physiology, Chulalongkorn University, Bangkok, Thailand, Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506, Siriraj Center of Excellence for Stem Cell Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Allergy and Clinical Immunology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, and National Nanotechnology Center, Pathumthani, Thailand yrojan@hsc.wvu.edu. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 499 EP - 511 VL - 143 IS - 2 KW - CASP8 and FADD-Like Apoptosis Regulating Protein KW - 0 KW - Nanotubes, Carbon KW - Receptors, Death Domain KW - Index Medicus KW - carbon nanotubes KW - c-FLIP KW - lung KW - apoptosis KW - death receptor KW - Gene Knockdown Techniques KW - Dose-Response Relationship, Drug KW - Humans KW - Cell Culture Techniques KW - Receptors, Death Domain -- metabolism KW - Cell Line KW - CASP8 and FADD-Like Apoptosis Regulating Protein -- metabolism KW - Drug Resistance -- drug effects KW - CASP8 and FADD-Like Apoptosis Regulating Protein -- antagonists & inhibitors KW - Cell Transformation, Neoplastic -- drug effects KW - Lung -- pathology KW - Lung -- metabolism KW - Nanotubes, Carbon -- toxicity KW - Epithelial Cells -- metabolism KW - Apoptosis -- genetics KW - CASP8 and FADD-Like Apoptosis Regulating Protein -- genetics KW - Epithelial Cells -- drug effects KW - Epithelial Cells -- pathology KW - Apoptosis -- drug effects KW - Lung -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652441335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Carbon+nanotubes+induce+apoptosis+resistance+of+human+lung+epithelial+cells+through+FLICE-inhibitory+protein.&rft.au=Pongrakhananon%2C+Varisa%3BLuanpitpong%2C+Sudjit%3BStueckle%2C+Todd+A%3BWang%2C+Liying%3BNimmannit%2C+Ubonthip%3BRojanasakul%2C+Yon&rft.aulast=Pongrakhananon&rft.aufirst=Varisa&rft.date=2015-02-01&rft.volume=143&rft.issue=2&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu251 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-01 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Part Fibre Toxicol. 2014;11:3 [24405760] Part Fibre Toxicol. 2013;10(1):53 [24144386] Cell Death Differ. 2014 Mar;21(3):451-61 [24270411] Part Fibre Toxicol. 2014;11:22 [24885671] J Immunol Res. 2014;2014:149185 [24901008] Part Fibre Toxicol. 2014;11:28 [24915862] Toxicon. 2014 Sep;87:120-30 [24932741] Oncotarget. 2014 Jun 15;5(11):3541-54 [24939878] Cancer Res. 2006 Feb 15;66(4):2367-75 [16489043] Toxicol Sci. 2006 Jul;92(1):5-22 [16484287] Free Radic Biol Med. 2007 May 15;42(10):1599-609 [17448907] J Bioenerg Biomembr. 2007 Feb;39(1):43-50 [17318397] Nat Rev Mol Cell Biol. 2001 Aug;2(8):589-98 [11483992] Mol Cell Biol. 2001 Dec;21(24):8247-54 [11713262] J Am Soc Nephrol. 2002 Apr;13(4):858-65 [11912244] Mol Cell. 2002 Mar;9(3):459-70 [11931755] Apoptosis. 2002 Aug;7(4):313-9 [12101390] Int J Oncol. 2003 Jan;22(1):15-20 [12469180] Acc Chem Res. 2002 Dec;35(12):1096-104 [12484798] J Cell Biochem. 2003 Apr 1;88(5):885-98 [12616528] Nat Immunol. 2003 Apr;4(4):308-10 [12660728] Oncogene. 2004 Apr 12;23(16):2785-96 [15077142] Oncogene. 2004 Oct 14;23(47):7753-60 [15334061] Int J Cancer. 1994 May 1;57(3):371-7 [8168998] J Immunol. 1996 Jan 1;156(1):13-7 [8598453] Nature. 1997 Jul 10;388(6638):190-5 [9217161] Science. 1998 Aug 28;281(5381):1305-8 [9721089] J Cell Sci. 2005 Jan 15;118(Pt 2):265-7 [15654015] J Biochem Mol Biol. 2002 Jan 31;35(1):24-7 [16248966] Eur Respir J. 2008 Dec;32(6):1631-8 [19043009] Toxicol Lett. 2009 May 8;186(3):166-73 [19114091] Toxicology. 2010 Mar 10;269(2-3):136-47 [19857541] J Cell Mol Med. 2010 Jun;14(6B):1760-76 [19538462] Cell Death Differ. 2010 Dec;17(12):1908-16 [20508645] Nano Lett. 2011 Jul 13;11(7):2796-803 [21657258] Mutat Res. 2012 Jun 14;745(1-2):28-37 [22178868] Exp Oncol. 2012 Oct;34(3):176-84 [23070002] Toxicol Sci. 2012 Dec;130(2):298-308 [22869613] Adv Drug Deliv Rev. 2013 Dec;65(15):2078-86 [23899865] J Immunol. 2008 Mar 1;180(5):3072-80 [18292530] J Toxicol Sci. 2008 Feb;33(1):105-16 [18303189] Int J Cancer. 2008 May 15;122(10):2210-22 [18214855] Science. 2008 May 2;320(5876):674-7 [18403674] Mol Cancer Ther. 2008 May;7(5):1156-63 [18483303] Nat Nanotechnol. 2008 Jul;3(7):423-8 [18654567] Mutat Res. 2008 Jul-Aug;659(1-2):15-30 [18485806] Oncol Rep. 2008 Sep;20(3):689-93 [18695925] Cancer Res. 2008 Aug 15;68(16):6652-60 [18701489] Environ Health Perspect. 2008 Sep;116(9):1211-7 [18795165] Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L552-65 [18658273] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu251 ER - TY - JOUR T1 - FutureTox II: in vitro data and in silico models for predictive toxicology. AN - 1652440978; 25628403 AB - FutureTox II, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in January, 2014. The meeting goals were to review and discuss the state of the science in toxicology in the context of implementing the NRC 21st century vision of predicting in vivo responses from in vitro and in silico data, and to define the goals for the future. Presentations and discussions were held on priority concerns such as predicting and modeling of metabolism, cell growth and differentiation, effects on sensitive subpopulations, and integrating data into risk assessment. Emerging trends in technologies such as stem cell-derived human cells, 3D organotypic culture models, mathematical modeling of cellular processes and morphogenesis, adverse outcome pathway development, and high-content imaging of in vivo systems were discussed. Although advances in moving towards an in vitro/in silico based risk assessment paradigm were apparent, knowledge gaps in these areas and limitations of technologies were identified. Specific recommendations were made for future directions and research needs in the areas of hepatotoxicity, cancer prediction, developmental toxicity, and regulatory toxicology. © The Author 2015. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Knudsen, Thomas B AU - Keller, Douglas A AU - Sander, Miriam AU - Carney, Edward W AU - Doerrer, Nancy G AU - Eaton, David L AU - Fitzpatrick, Suzanne Compton AU - Hastings, Kenneth L AU - Mendrick, Donna L AU - Tice, Raymond R AU - Watkins, Paul B AU - Whelan, Maurice AD - United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy. ; United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy douglas.keller@sanofi.com. ; United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 256 EP - 267 VL - 143 IS - 2 KW - Index Medicus KW - predictive toxicology KW - in silico KW - modeling KW - in vitro KW - risk assessment KW - United States KW - Societies, Scientific KW - Predictive Value of Tests KW - Congresses as Topic KW - Computer Simulation KW - Toxicology -- trends KW - In Vitro Techniques KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652440978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=FutureTox+II%3A+in+vitro+data+and+in+silico+models+for+predictive+toxicology.&rft.au=Knudsen%2C+Thomas+B%3BKeller%2C+Douglas+A%3BSander%2C+Miriam%3BCarney%2C+Edward+W%3BDoerrer%2C+Nancy+G%3BEaton%2C+David+L%3BFitzpatrick%2C+Suzanne+Compton%3BHastings%2C+Kenneth+L%3BMendrick%2C+Donna+L%3BTice%2C+Raymond+R%3BWatkins%2C+Paul+B%3BWhelan%2C+Maurice&rft.aulast=Knudsen&rft.aufirst=Thomas&rft.date=2015-02-01&rft.volume=143&rft.issue=2&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu234 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-01 N1 - Date created - 2015-01-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Toxicol Chem. 2011 Jan;30(1):9-21 [20963854] Nat Biotechnol. 2014 Jun;32(6):583-91 [24837663] Toxicol Sci. 2011 Sep;123(1):281-9 [21693436] Environ Health Perspect. 2015 Mar;123(3):237-45 [25376053] Birth Defects Res C Embryo Today. 2011 Dec;93(4):312-23 [22271680] Genetics. 2012 Feb;190(2):389-401 [22345608] Toxicol Sci. 2012 Apr;126(2):291-7 [22262567] Nat Rev Cancer. 2007 Jan;7(1):54-60 [17186018] Genome Biol. 2006;7(7):R61 [16859521] Arch Intern Med. 2007 Sep 10;167(16):1752-9 [17846394] Science. 2008 Feb 15;319(5865):906-7 [18276874] Toxicol Sci. 2009 Mar;108(1):19-21 [19168570] Environ Health Perspect. 2009 Apr;117(4):624-31 [19440503] Toxicol Sci. 2009 Jul;110(1):40-6 [19435982] Toxicol Sci. 2009 Aug;110(2):251-4 [19468057] Toxicol Sci. 2009 Nov;112(1):17-22 [19703945] Toxicol Sci. 2009 Dec;112(2):297-302 [19805406] Toxicol Sci. 2010 Mar;114(1):20-4 [20026472] Toxicol Sci. 2010 Sep;117(1):17-24 [20573784] Environ Toxicol Chem. 2010 Mar;29(3):730-41 [20821501] N Engl J Med. 2010 Oct 7;363(15):1397-409 [20660394] Environ Toxicol Chem. 2011 Jan;30(1):64-76 [20963853] Toxicol Sci. 2011 Oct;123(2):349-58 [21750347] BMC Syst Biol. 2011;5:190 [22074594] Toxicol Sci. 2012 Jan;125(1):157-74 [21948869] Methods Cell Biol. 2012;110:325-66 [22482955] J Mol Cell Cardiol. 2012 May;52(5):998-1008 [22353256] J Pharmacol Exp Ther. 2012 May;341(2):510-7 [22353878] Chem Res Toxicol. 2012 Jul 16;25(7):1287-302 [22519603] Trends Biotechnol. 2012 Aug;30(8):421-5 [22652049] Environ Health Perspect. 2013 Jan;121(1):7-14 [23052129] Environ Health Perspect. 2013 Jan;121(1):23-31 [23086705] Methods Mol Biol. 2013;969:3-28 [23296924] Toxicol Sci. 2013 Apr;132(2):327-46 [23358191] Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1053-63 [23485712] Toxicol Sci. 2013 Jul;134(1):180-94 [23596260] Environ Health Perspect. 2013 Jul;121(7):756-65 [23603828] Nat Rev Drug Discov. 2013 Aug;12(8):565-7 [23903208] Science. 2013 Aug 9;341(6146):651-4 [23868920] Toxicol Appl Pharmacol. 2013 Sep 15;271(3):309-23 [20353796] Toxicology. 2013 Oct 4;312:158-65 [23978457] Chem Res Toxicol. 2013 Dec 16;26(12):1840-61 [24206190] Toxicol Sci. 2014 Feb;137(2):269-77 [24204016] Stem Cell Res Ther. 2013;4 Suppl 1:I1 [24565163] J Appl Toxicol. 2014 Jan;34(1):1-18 [24166207] Chem Res Toxicol. 2014 Mar 17;27(3):314-29 [24446777] J Chem Inf Model. 2014 Jan 27;54(1):1-4 [24251851] Chem Res Toxicol. 2011 Aug 15;24(8):1251-62 [21699217] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu234 ER - TY - JOUR T1 - The cytotoxic mechanism of karlotoxin 2 (KmTx 2) from Karlodinium veneficum (Dinophyceae). AN - 1652427671; 25546005 AB - This study demonstrates that the polyketide toxin karlotoxin 2 (KmTx 2) produced by Karlodinium veneficum, a dinoflagellate associated with fish kills in temperate estuaries world-wide, alters vertebrate cell membrane permeability. Microfluorimetric and electrophysiological measurements were used to determine that vertebrate cellular toxicity occurs through non-selective permeabilization of plasma membranes, leading to osmotic cell lysis. Previous studies showed that KmTx 2 is lethal to fish at naturally-occurring concentrations measured during fish kills, while sub-lethal doses severely damage gill epithelia. This study provides a mechanistic explanation for the association between K. veneficum blooms and fish kills that has long been observed in temperate estuaries worldwide. Published by Elsevier B.V. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Deeds, Jonathan R AU - Hoesch, Robert E AU - Place, Allen R AU - Kao, Joseph P Y AD - University of Maryland Center for Environmental Science, Institute of Marine and Environmental Technology, 701 East Pratt Street, Suite 236, Baltimore, MD 21202, USA. Electronic address: jonathan.deeds@fda.hhs.gov. ; University of Maryland, Baltimore, Center for Biomedical Engineering and Technology and Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. ; University of Maryland Center for Environmental Science, Institute of Marine and Environmental Technology, 701 East Pratt Street, Suite 236, Baltimore, MD 21202, USA. Electronic address: place@umces.edu. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 148 EP - 155 VL - 159 KW - Pyrans KW - 0 KW - Water Pollutants, Chemical KW - karlotoxin-2 KW - Index Medicus KW - Karlotoxin KW - Colloid osmotic lysis KW - Non-selective membrane permeability KW - Pore-forming toxin KW - Fish kills KW - Rats KW - Erythrocytes -- drug effects KW - Animals KW - Dinoflagellida -- physiology KW - Cell Membrane Permeability -- drug effects KW - Cell Membrane -- drug effects KW - Fishes KW - Rabbits KW - Male KW - Cell Line KW - Dinoflagellida -- chemistry KW - Pyrans -- pharmacology KW - Water Pollutants, Chemical -- pharmacology KW - Water Pollutants, Chemical -- toxicity KW - Pyrans -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652427671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=The+cytotoxic+mechanism+of+karlotoxin+2+%28KmTx+2%29+from+Karlodinium+veneficum+%28Dinophyceae%29.&rft.au=Deeds%2C+Jonathan+R%3BHoesch%2C+Robert+E%3BPlace%2C+Allen+R%3BKao%2C+Joseph+P+Y&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2015-02-01&rft.volume=159&rft.issue=&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=1879-1514&rft_id=info:doi/10.1016%2Fj.aquatox.2014.11.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-27 N1 - Date created - 2015-01-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Nat Prod. 2010 Aug 27;73(8):1360-5 [20795740] Bioorg Med Chem Lett. 2010 Apr 1;20(7):2215-8 [20207137] Methods Cell Biol. 2010;99:113-52 [21035685] J Neurophysiol. 2001 Jul;86(1):190-6 [11431501] Infect Immun. 2000 Jun;68(6):3180-5 [10816461] J Biol Chem. 1985 Mar 25;260(6):3440-50 [3838314] J Physiol. 1979 Jan;286:417-45 [312319] Pflugers Arch. 1981 Aug;391(2):85-100 [6270629] Biochimie. 1989 Jan;71(1):37-47 [2497796] Eur J Cell Biol. 1990 Apr;51(2):252-8 [1693573] Am J Physiol. 1993 Aug;265(2 Pt 2):H604-15 [8368363] J Auton Nerv Syst. 1993 Oct;45(1):29-39 [7901264] Methods Cell Biol. 1994;40:155-81 [8201975] Nat Toxins. 1998;6(1):35-41 [9851510] Biochim Biophys Acta. 2004 Nov 17;1667(1):91-100 [15533309] Bioorg Med Chem. 2008 Mar 15;16(6):3084-90 [18180163] Org Lett. 2008 Nov 20;10(22):5203-6 [18959425] J Am Chem Soc. 2010 Mar 17;132(10):3277-9 [20155901] Nat Prod Rep. 2010 Oct;27(10):1480-92 [20820637] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.aquatox.2014.11.028 ER - TY - JOUR T1 - Cytotoxic mechanism of cytolethal distending toxin in nontyphoidal Salmonella serovar (Salmonella Javiana) during macrophage infection. AN - 1652425305; 25389664 AB - Cytolethal distending toxin B (cdtB) is a conserved virulence factor in Salmonella enterica serovar Typhi. Here we report the presence and functionality of cdtB in some nontyphoidal Salmonella (NTS) serovars, including Salmonella Javiana (cdtB+wt S. Javiana), isolated from imported food. To understand the role of cdtB in NTS serovars, a deletion mutant (cdtB(-)ΔS. Javiana) was constructed. Macrophages were infected with cdtB+wt S. Javiana (wild type), cdtB(-)Δ S. Javiana (mutant), and cdtB-negative NTS serovar (S. Typhimurium). Cytotoxic activity and transcription level of genes involved in cell death (apoptosis, autophagy, and necrosis) were assessed in infected macrophages. The cdtB+wt S. Javiana caused cellular distension as well as high degree of vacuolization and presence of the autophagosome marker LC3 in infected macrophages as compared with cdtB(-)ΔS. Javiana. The mRNA expression of genes involved in the induction of autophagy in response to toxin (Esr1 and Pik3C3) and coregulators of autophagy and apoptosis (Bax and Cyld) were significantly upregulated in cdtB(+)wt S. Javiana-infected macrophages. As autophagy destroys internalized pathogens in addition to the infected cell, it may reduce the spread of infection. JF - DNA and cell biology AU - Williams, Katherine AU - Gokulan, Kuppan AU - Shelman, Diamond AU - Akiyama, Tatsuya AU - Khan, Ashraf AU - Khare, Sangeeta AD - Division of Microbiology, National Center for Toxicological Research , U.S. Food and Drug Administration, Jefferson, Arkansas. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 113 EP - 124 VL - 34 IS - 2 KW - Bacterial Toxins KW - 0 KW - Estrogen Receptor alpha KW - MAP1LC3 protein, mouse KW - Microtubule-Associated Proteins KW - bcl-2-Associated X Protein KW - cytolethal distending toxin KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - CYLD protein, mouse KW - EC 3.1.2.15 KW - Cysteine Endopeptidases KW - EC 3.4.22.- KW - Index Medicus KW - Phosphatidylinositol 3-Kinases -- genetics KW - Animals KW - Autophagy -- genetics KW - Cell Survival -- genetics KW - Gene Expression KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Cell Shape -- genetics KW - Microscopy, Fluorescence KW - bcl-2-Associated X Protein -- genetics KW - Necrosis -- genetics KW - Microtubule-Associated Proteins -- genetics KW - Apoptosis -- genetics KW - Estrogen Receptor alpha -- genetics KW - Host-Pathogen Interactions -- genetics KW - Cell Line KW - Cysteine Endopeptidases -- genetics KW - Macrophages -- cytology KW - Bacterial Toxins -- genetics KW - Salmonella -- genetics KW - Salmonella -- physiology KW - Macrophages -- microbiology KW - Salmonella -- classification KW - Mutation KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652425305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+and+cell+biology&rft.atitle=Cytotoxic+mechanism+of+cytolethal+distending+toxin+in+nontyphoidal+Salmonella+serovar+%28Salmonella+Javiana%29+during+macrophage+infection.&rft.au=Williams%2C+Katherine%3BGokulan%2C+Kuppan%3BShelman%2C+Diamond%3BAkiyama%2C+Tatsuya%3BKhan%2C+Ashraf%3BKhare%2C+Sangeeta&rft.aulast=Williams&rft.aufirst=Katherine&rft.date=2015-02-01&rft.volume=34&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=DNA+and+cell+biology&rft.issn=1557-7430&rft_id=info:doi/10.1089%2Fdna.2014.2602 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-21 N1 - Date created - 2015-01-29 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1089/dna.2014.2602 ER - TY - JOUR T1 - Molecular and epidemiological review of toxigenic diphtheria infections in England between 2007 and 2013. AN - 1652412482; 25502525 AB - Human infections caused by toxigenic corynebacteria occur sporadically across Europe. In this report, we undertook the epidemiological and molecular characterization of all toxigenic corynebacterium strains isolated in England between January 2007 and December 2013. Epidemiological aspects include case demographics, risk factors, clinical presentation, treatment, and outcome. Molecular characterization was performed using multilocus sequence typing (MLST) alongside traditional phenotypic methods. In total, there were 20 cases of toxigenic corynebacteria; 12 (60.0%) were caused by Corynebacterium ulcerans, where animal contact was the predominant risk factor. The remaining eight (40.0%) were caused by Corynebacterium diphtheriae strains; six were biovar mitis, which were associated with recent travel abroad. Adults 45 years and older were particularly affected (55.0%; 11/20), and typical symptoms included sore throat and fever. Respiratory diphtheria with the absence of a pharyngeal membrane was the most common presentation (50.0%; 10/20). None of the eight C. diphtheriae cases were fully immunized. Diphtheria antitoxin was issued in two (9.5%) cases; both survived. Two (9.5%) cases died, one due to a C. diphtheriae infection and one due to C. ulcerans. MLST demonstrated that the majority (87.5%; 7/8) of C. diphtheriae strains represented new sequence types (STs). By adapting several primer sequences, the MLST genes in C. ulcerans were also amplified, thereby providing the basis for extension of the MLST scheme, which is currently restricted to C. diphtheriae. Despite high population immunity, occasional toxigenic corynebacterium strains are identified in England and continued surveillance is required. Copyright © 2015, American Society for Microbiology. All Rights Reserved. JF - Journal of clinical microbiology AU - Both, Leonard AU - Collins, Sarah AU - de Zoysa, Aruni AU - White, Joanne AU - Mandal, Sema AU - Efstratiou, Androulla AD - WHO Global Reference Centre for Diphtheria and Streptococcal Infections, Public Health England (PHE), London, United Kingdom. ; Immunisation, Hepatitis and Blood Safety Department, Centre for Infectious Disease Surveillance and Control, Public Health England (PHE), London, United Kingdom. ; WHO Global Reference Centre for Diphtheria and Streptococcal Infections, Public Health England (PHE), London, United Kingdom Androulla.Efstratiou@phe.gov.uk. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 567 EP - 572 VL - 53 IS - 2 KW - Diphtheria Toxin KW - 0 KW - Index Medicus KW - Young Adult KW - Animals KW - Humans KW - Aged KW - Child KW - Multilocus Sequence Typing KW - Demography KW - Aged, 80 and over KW - England -- epidemiology KW - Risk Factors KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Corynebacterium -- isolation & purification KW - Corynebacterium Infections -- drug therapy KW - Corynebacterium -- genetics KW - Corynebacterium Infections -- pathology KW - Corynebacterium -- classification KW - Diphtheria Toxin -- secretion KW - Corynebacterium Infections -- microbiology KW - Corynebacterium Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652412482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Molecular+and+epidemiological+review+of+toxigenic+diphtheria+infections+in+England+between+2007+and+2013.&rft.au=Both%2C+Leonard%3BCollins%2C+Sarah%3Bde+Zoysa%2C+Aruni%3BWhite%2C+Joanne%3BMandal%2C+Sema%3BEfstratiou%2C+Androulla&rft.aulast=Both&rft.aufirst=Leonard&rft.date=2015-02-01&rft.volume=53&rft.issue=2&rft.spage=567&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=1098-660X&rft_id=info:doi/10.1128%2FJCM.03398-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-22 N1 - Date created - 2015-01-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Euro Surveill. 2014;19(24). pii: 20830 [24970373] Vaccine. 2012 Nov 19;30(49):7111-7 [23022148] J Infect Dis. 2000 Feb;181 Suppl 1:S116-20 [10657202] J Infect Dis. 2000 Feb;181 Suppl 1:S168-77 [10657209] Epidemiol Infect. 2000 Aug;125(1):113-25 [11057967] J Clin Microbiol. 1997 Feb;35(2):495-8 [9003626] Vet Res. 2006 Mar-Apr;37(2):201-18 [16472520] J Clin Microbiol. 2006 May;44(5):1625-9 [16672385] J Clin Microbiol. 2008 Nov;46(11):3626-35 [18784317] Epidemiol Infect. 2010 Nov;138(11):1519-30 [20696088] Clin Microbiol Infect. 2011 Apr;17(4):519-25 [20491827] J Clin Microbiol. 2011 Jul;49(7):2664-6 [21525220] Emerg Infect Dis. 2012 Feb;18(2):217-25 [22304732] Epidemiol Infect. 2012 Apr;140(4):617-20 [21669023] Infection. 2012 Oct;40(5):575-8 [22403045] J Clin Microbiol. 2010 Nov;48(11):4177-85 [20844217] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/JCM.03398-14 ER - TY - JOUR T1 - Functional analysis of dengue virus (DENV) type 2 envelope protein domain 3 type-specific and DENV complex-reactive critical epitope residues. AN - 1652408412; 25351518 AB - The dengue virus (DENV) envelope protein domain 3 (ED3) is the target of potent virus neutralizing antibodies. The DENV-2 ED3 contains adjacent type-specific and DENV complex-reactive antigenic sites that are composed of a small number of residues that were previously demonstrated to be critical for antibody binding. Site-directed mutagenesis of a DENV-2 16681 infectious clone was used to mutate critical residues in the DENV-2 type-specific (K305A and P384A) and DENV complex-reactive (K310A) antigenic sites. The K305A mutant virus multiplied like the parent virus in mosquito and mammalian cells, as did the P384A mutant virus, which required a compensatory mutation (G330D) for viability. However, the K310A mutant virus could not be recovered. The DENV-2 type-specific critical residue mutations K305A and P384A+G330D reduced the ability of DENV-2 type-specific, but not DENV complex-reactive, mAbs to neutralize virus infectivity and this was directly correlated with mAb binding affinity to the rED3 mutants. © 2015 The Authors. JF - The Journal of general virology AU - Pitcher, Trevor J AU - Sarathy, Vanessa V AU - Matsui, Kiyohiko AU - Gromowski, Gregory D AU - Huang, Claire Y-H AU - Barrett, Alan D T AD - Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0436, USA. ; Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Fort Collins, CO 80521, USA. ; Center for Biodefense and Emerging Infectious Diseases, Sealy Center for Vaccine Development, Institute for Human Infections and Immunity, and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555-0436, USA abarrett@utmb.edu. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 288 EP - 293 VL - 96 KW - Antibodies, Neutralizing KW - 0 KW - Antibodies, Viral KW - Epitopes KW - Viral Envelope Proteins KW - Index Medicus KW - Virus Replication KW - Mutagenesis, Site-Directed KW - Microbial Viability KW - Models, Molecular KW - DNA Mutational Analysis KW - Antibodies, Neutralizing -- immunology KW - Antibodies, Viral -- immunology KW - Protein Conformation KW - Viral Envelope Proteins -- immunology KW - Epitopes -- genetics KW - Dengue Virus -- immunology KW - Dengue Virus -- genetics KW - Epitopes -- immunology KW - Viral Envelope Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652408412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+general+virology&rft.atitle=Functional+analysis+of+dengue+virus+%28DENV%29+type+2+envelope+protein+domain+3+type-specific+and+DENV+complex-reactive+critical+epitope+residues.&rft.au=Pitcher%2C+Trevor+J%3BSarathy%2C+Vanessa+V%3BMatsui%2C+Kiyohiko%3BGromowski%2C+Gregory+D%3BHuang%2C+Claire+Y-H%3BBarrett%2C+Alan+D+T&rft.aulast=Pitcher&rft.aufirst=Trevor&rft.date=2015-02-01&rft.volume=96&rft.issue=&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+general+virology&rft.issn=1465-2099&rft_id=info:doi/10.1099%2Fvir.0.070813-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-30 N1 - Date created - 2015-01-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Virol. 2010 Sep;84(18):9227-39 [20592088] Virology. 2010 Jan 20;396(2):305-15 [19913272] EMBO Mol Med. 2014 Mar;6(3):358-71 [24421336] Virology. 2010 Nov 25;407(2):237-46 [20832836] Virology. 2012 Jan 20;422(2):386-92 [22153298] Structure. 2012 Feb 8;20(2):303-14 [22285214] J Virol. 2012 Apr;86(7):4019-23 [22278250] J Infect Dis. 2013 Jun 15;207(12):1898-908 [23526830] Virology. 2013 Jul 5;441(2):114-25 [23571092] Cell. 2002 Mar 8;108(5):717-25 [11893341] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91 [12759475] J Virol. 2004 Jan;78(1):378-88 [14671119] Annu Rev Microbiol. 1990;44:649-88 [2174669] Virology. 1996 Oct 15;224(2):437-45 [8874504] Virology. 1997 Apr 14;230(2):300-8 [9143286] Nat Med. 1997 Aug;3(8):866-71 [9256277] Virology. 1998 Jul 5;246(2):317-28 [9657950] Virology. 2007 Sep 30;366(2):349-60 [17719070] J Virol. 2007 Dec;81(23):12816-26 [17881453] Expert Rev Mol Med. 2008;10:e12 [18471342] J Virol. 2008 Sep;82(17):8828-37 [18562544] Cell Host Microbe. 2008 Sep 11;4(3):229-38 [18779049] Virology. 2010 Oct 25;406(2):328-35 [20708768] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1099/vir.0.070813-0 ER - TY - JOUR T1 - Cell streak imaging cytometry for rare cell detection AN - 1647003823; 21284949 AB - Detection of rare cells, such as circulating tumor cells, have many clinical applications. To measure rare cells with increased sensitivity and improved data managements, we developed an imaging flow cytometer with a streak imaging mode capability. The new streak mode imaging mode utilizes low speed video to capture moving fluorescently labeled cells in a flow cell. Each moving cell is imaged on multiple pixels on each frame, where the cell path is marked as a streak line proportional to the length of the exposure. Finding rare cells (e.g., <1 cell/mL) requires measuring larger sample volumes to achieve higher sensitivity, therefore we combined streak mode imaging with a "wide" high throughput flow cell (e.g. flow rates set to 10mL/min) in contrast to the conventional "narrow" hydrodynamic focusing cells typically used in cytometry that are inherently limited to low flow rates. The new flow cell is capable of analyzing 20mL/min of fluorescently labeled cells. To further increase sensitivity, the signal to noise ratio of the images was also enhanced by combining three imaging methods: (1) background subtraction, (2) pixel binning, and (3) CMOS color channel selection. The streaking mode cytometer has been used for the analysis of SYTO-9 labeled THP-1 human monocytes in buffer and in blood. Samples of cells at 1 cell/mL and 0.1 cell/mL were analyzed in 30mL with flow rates set to 10mL/min and frame rates of 4fps (frame per second). For the target of 1 cell/mL, an average concentration of 0.91 cell/mL was measured by cytometry, with a standard error of 0.03 (C 95=0.85-0.97). For the target of 0.1 cell/mL, an average concentration of 0.083 cell/mL was measured, with a standard error of 0.01 (C 95=0.065-0.102). Whole blood was also spiked with SYTO-9 labeled cells to a concentration of 10 cell/mL, and the average flow cytometry measurement was 8.7 cells/mL (i.e. 0.87 cells/mL in diluted blood) with a 95% CL of 8.1-9.2 cells/mL. This demonstrated the ability to detect rare cells in blood with high accuracy. Such detection approaches for rare cells have many potential clinical applications. Furthermore, the simplicity and low cost of this device may enable expansion of cell-based clinical diagnostics, especially in resource-poor settings. JF - Biosensors and Bioelectronics AU - Balsam, Joshua AU - Bruck, Hugh Alan AU - Rasooly, Avraham AD - Division of Biology, Office of Science and Engineering, FDA, Silver Spring, MD 20993, United States Y1 - 2015/02// PY - 2015 DA - Feb 2015 SP - 154 EP - 160 PB - Elsevier B.V., 660 White Plains Rd. Tarrytown NY 10591-5153 United States VL - 64 SN - 0956-5663, 0956-5663 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Wide-field imaging KW - Rare cells KW - Resource-poor settings KW - Image enhancement KW - mHealth KW - Data processing KW - Hydrodynamics KW - Therapeutic applications KW - Streak KW - imaging KW - Tumor cells KW - Cytometry KW - Color KW - Biosensors KW - Blood KW - Monocytes KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647003823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=Cell+streak+imaging+cytometry+for+rare+cell+detection&rft.au=Balsam%2C+Joshua%3BBruck%2C+Hugh+Alan%3BRasooly%2C+Avraham&rft.aulast=Balsam&rft.aufirst=Joshua&rft.date=2015-02-01&rft.volume=64&rft.issue=&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2014.08.065 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Biosensors; Flow cytometry; Blood; Data processing; Hydrodynamics; Therapeutic applications; Monocytes; Streak; Tumor cells; imaging; Cytometry; Color DO - http://dx.doi.org/10.1016/j.bios.2014.08.065 ER - TY - JOUR T1 - An analysis of legal warnings after drug approval in Thailand. AN - 1640689128; 25445000 AB - Drug risk management has many tools for minimizing risk and black-boxed warnings (BBWs) are one of those tools. Some serious adverse drug reactions (ADRs) emerge only after a drug is marketed and used in a larger population. In Thailand, additional legal warnings after drug approval, in the form of black-boxed warnings, may be applied. Review of their characteristics can assist in the development of effective risk mitigation. This study was a cross sectional review of all legal warnings imposed in Thailand after drug approval (2003-2012). Any boxed warnings for biological products and revised warnings which were not related to safety were excluded. Nine legal warnings were evaluated. Seven related to drugs classes and two to individual drugs. The warnings involved four main types of predictable ADRs: drug-disease interactions, side effects, overdose and drug-drug interactions. The average time from first ADRs reported to legal warnings implementation was 12 years. The triggers were from both safety signals in Thailand and regulatory measures in other countries outside Thailand. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Sriphiromya, Pakawadee AU - Theeraroungchaisri, Anuchai AD - Health Product Vigilance Center, Food and Drug Administration, Ministry of Public Health, Thailand; Chulalongkorn University, Phayathai Road, Bangkok, Thailand. Electronic address: pspakawadee@gmail.com. ; Chulalongkorn University, Phayathai Road, Bangkok, Thailand. Y1 - 2015/02// PY - 2015 DA - February 2015 SP - 108 EP - 113 VL - 71 IS - 1 KW - Index Medicus KW - Legal warnings KW - Pharmacovigilance KW - Drug risk management KW - Drug safety KW - Adverse drug reactions KW - Drug Interactions KW - Government Regulation KW - Thailand KW - Drug Approval KW - Drug Overdose KW - Federal Government KW - Drug-Related Side Effects and Adverse Reactions KW - Product Surveillance, Postmarketing KW - Drug Labeling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640689128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=An+analysis+of+legal+warnings+after+drug+approval+in+Thailand.&rft.au=Sriphiromya%2C+Pakawadee%3BTheeraroungchaisri%2C+Anuchai&rft.aulast=Sriphiromya&rft.aufirst=Pakawadee&rft.date=2015-02-01&rft.volume=71&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.10.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-02 N1 - Date created - 2014-12-26 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.10.013 ER - TY - JOUR T1 - Determination of Neurotoxic Acetogenins in Pawpaw (Asimina triloba) Fruit by LC-HRMS. AN - 1826609368; 25594104 AB - The concentrations of the neurotoxins, annonacin and squamocin, were determined in a lyophilized sample of the fruit pulp of the North American pawpaw (Asimina triloba) by LC coupled to high resolution mass spectrometry or LC-HRMS. The sample was extracted using dry methanol at 100 °C and 10 MPa pressure in a sealed container. The extraction of annonacin and squamocin was optimal at 100 °C with 7.72 and 0.162 mg/g, respectively, being found. Also, several isomers of annonacin and squamocin were separated and detected but not quantified. JF - Journal of agricultural and food chemistry AU - Levine, Robert A AU - Richards, Kristy M AU - Tran, Kevin AU - Luo, Rensheng AU - Thomas, Andrew L AU - Smith, Robert E AD - U.S. Food and Drug Administration, Total Diet and Pesticide Research Center, 11510 West 80th Street, Lenexa, Kansas 66214, United States. Y1 - 2015/01/22/ PY - 2015 DA - 2015 Jan 22 KW - pawpaw KW - Parkinson’s disease KW - LC-HRMS KW - squamocin KW - annonacin KW - Asimina triloba UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826609368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Determination+of+Neurotoxic+Acetogenins+in+Pawpaw+%28Asimina+triloba%29+Fruit+by+LC-HRMS.&rft.au=Levine%2C+Robert+A%3BRichards%2C+Kristy+M%3BTran%2C+Kevin%3BLuo%2C+Rensheng%3BThomas%2C+Andrew+L%3BSmith%2C+Robert+E&rft.aulast=Levine&rft.aufirst=Robert&rft.date=2015-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2015-01-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Repeated Dose 90-Day Feeding Study of Whole Fruits of Genetically Modified Papaya Resistant to Papaya Ringspot Virus in Rats. AN - 1826608918; 25578800 AB - Genetically modified (GM) papaya plants resistant to infection by Papaya ringspot virus (PRSV) have been successfully generated by cloning the coat protein (CP) gene of PRSV to increase fruit production. In this study, the GM papaya line 823-2210 was used to conduct a 90-day feeding toxicity study and compared to its parent plant of non-GM papaya, Tainung-2 (TN-2) based on the experimental guidance reported by the European Food Safety Authority.1 Ten male and 10 female Sprague-Dawley albino rats were gavaged at low (1 g/kg bw) and high (2 g/kg bw) doses of non-GM and GM lyophilized papaya fruits for 90 days. Hematology, coagulation, biochemistry, urinalysis, and pathology were examined in all animals. Although some differences were found in feed consumption, hematology, and serum chemistry examinations between non-GM and GM papaya, the results were within historical control values and not considered biologically significant in rats. In addition, there were no treatment-related gross or microscopic lesions in male or female rats attributable to the non-GM or GM papaya fruit. This 90-day feeding study of GM papaya fruit did not reveal adverse effects in rats and indicates that GM papaya fruits may be substantially equivalent to their non-GM parent plants. JF - Journal of agricultural and food chemistry AU - Lin, Hsin-Tang AU - Yen, Gow-Chin AU - Lee, Wei-Cheng AU - Tsai, Yi-Ting AU - Wu, Jhaol-Huei AU - Yeh, Shyi-Dong AU - Cheng, Ying-Huey AU - Chang, Shih-Chieh AU - Liao, Jiunn-Wang AD - Food and Drug Administration, Ministry of Health and Welfare , Taipei 115, Taiwan, Republic of China. Y1 - 2015/01/21/ PY - 2015 DA - 2015 Jan 21 KW - genetically modified KW - papaya KW - PRSV KW - subchronic feeding toxicity KW - rats UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826608918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Repeated+Dose+90-Day+Feeding+Study+of+Whole+Fruits+of+Genetically+Modified+Papaya+Resistant+to+Papaya+Ringspot+Virus+in+Rats.&rft.au=Lin%2C+Hsin-Tang%3BYen%2C+Gow-Chin%3BLee%2C+Wei-Cheng%3BTsai%2C+Yi-Ting%3BWu%2C+Jhaol-Huei%3BYeh%2C+Shyi-Dong%3BCheng%2C+Ying-Huey%3BChang%2C+Shih-Chieh%3BLiao%2C+Jiunn-Wang&rft.aulast=Lin&rft.aufirst=Hsin-Tang&rft.date=2015-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2015-01-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Cluster III of low-density lipoprotein receptor-related protein 1 binds activated blood coagulation factor VIII. AN - 1652394606; 25486042 AB - Low-density lipoprotein receptor-related protein 1 (LRP) mediates clearance of blood coagulation factor VIII (FVIII). In LRP, FVIII binds the complement-type repeats (CRs) of clusters II and IV, which also bind a majority of other LRP ligands. No ligand is known for LRP cluster I, and only three ligands, including the LRP chaperone alpha-2 macroglobulin receptor-associated protein (RAP), bind cluster III. Using surface plasmon resonance, we found that in addition to clusters II and IV, activated FVIII (FVIIIa) binds cluster III. The specificity of this interaction was confirmed using an anti-FVIII antibody fragment, which inhibited the binding. Recombinant fragments of cluster III and its site-directed mutagenesis were used to localize the cluster's site for binding FVIIIa to CR.14-19. The interactive site of FVIIIa was localized within its A1/A3'-C1-C2 heterodimer (HDa), which is a major physiological remnant of FVIIIa. In mice, the clearance of HDa was faster than that of FVIII and prolonged in the presence of RAP, which is known to inhibit interactions of LRP with its ligands. In accordance with this, the cluster III site for RAP (CR.15-19) was found to overlap that for FVIIIa. Altogether, our findings support the involvement of LRP in FVIIIa catabolism and suggest a greater significance of the biological role of cluster III compared to that previously known. JF - Biochemistry AU - Kurasawa, James H AU - Shestopal, Svetlana A AU - Woodle, Samuel A AU - Ovanesov, Mikhail V AU - Lee, Timothy K AU - Sarafanov, Andrey G AD - Center for Biologics Evaluation and Research, Food and Drug Administration , Silver Spring, Maryland 20993-0002, United States. Y1 - 2015/01/20/ PY - 2015 DA - 2015 Jan 20 SP - 481 EP - 489 VL - 54 IS - 2 KW - LDL-Receptor Related Protein-Associated Protein KW - 0 KW - Low Density Lipoprotein Receptor-Related Protein-1 KW - Recombinant Proteins KW - Factor VIIIa KW - 72175-66-7 KW - Factor VIII KW - 9001-27-8 KW - Index Medicus KW - LDL-Receptor Related Protein-Associated Protein -- metabolism KW - Factor VIII -- metabolism KW - Animals KW - Protein Interaction Mapping KW - Recombinant Proteins -- metabolism KW - Mice KW - Recombinant Proteins -- chemistry KW - Mice, Inbred BALB C KW - Protein Multimerization KW - Protein Binding KW - Factor VIII -- chemistry KW - Binding Sites KW - Low Density Lipoprotein Receptor-Related Protein-1 -- metabolism KW - Low Density Lipoprotein Receptor-Related Protein-1 -- chemistry KW - Factor VIIIa -- chemistry KW - Factor VIIIa -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652394606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Cluster+III+of+low-density+lipoprotein+receptor-related+protein+1+binds+activated+blood+coagulation+factor+VIII.&rft.au=Kurasawa%2C+James+H%3BShestopal%2C+Svetlana+A%3BWoodle%2C+Samuel+A%3BOvanesov%2C+Mikhail+V%3BLee%2C+Timothy+K%3BSarafanov%2C+Andrey+G&rft.aulast=Kurasawa&rft.aufirst=James&rft.date=2015-01-20&rft.volume=54&rft.issue=2&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=1520-4995&rft_id=info:doi/10.1021%2Fbi5011688 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-08 N1 - Date created - 2015-01-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/bi5011688 ER - TY - RPRT T1 - PROPOSED RULE: STANDARDS FOR GROWING, HARVESTING, PACKING, AND HOLDING OF PRODUCE FOR HUMAN CONSUMPTION. AN - 16393956; 16384 AB - PURPOSE: The Food Safety Modernization Act of 2011 (FSMA) directs FDA to build a new food safety system based on the public health principle of comprehensive prevention, an enhanced focus on risk-based resource allocation, and partnership across the public and private sectors to minimize food and feed hazards from farm to table. As such, FSMA gives FDA the public health mandate to establish standards for the adoption of modern food safety prevention practices by those who grow, process, transport, and store food. Through FSMA, FDA has proposed seven rules for stakeholders (food producers, suppliers, distributors) to follow in the supply chain that would protect public health by promoting safe, sanitary standards that, when implemented, would minimize or prevent food safety hazards. One of the Proposed Rules: Standards for Growing, Harvesting, Packing, and Holding of Produce for Human Consumption (Produce Safety Proposed Rule or PS PR) is the subject of this Draft Environmental Impact Statement (EIS). The purpose of proposing this rule is to minimize the risk of serious adverse health consequences or death, including those actions reasonably necessary to prevent the introduction of known or reasonably foreseeable biological hazards into or onto produce and to provide reasonable assurances that the produce is not adulterated on account of such hazards. FDA announced its intent to prepare an EIS and began the EIS scoping period in August 2013. This EIS, prepared in accordance with the National Environmental Policy Act and developed by the FDA in cooperation with the U.S. Department of Agriculture, assesses the environmental (including human) and related socioeconomic impacts based on potentially significant provisions of the PS PR, and alternatives to the provisions that were considered. The No Action Alternative is also assessed in this EIS as a basis for comparison, to determine the environmental impacts associated with existing conditions (current practices, laws, and procedures) if the PS PR were not implemented. JF - EPA number: 150004, Draft EIS, January 16, 2015 Y1 - 2015/01/16/ PY - 2015 DA - 2015 Jan 16 KW - Hazardous Substances KW - Public Health KW - Health Hazards KW - Farm Management KW - Water Quality KW - Fertilizers KW - Farmlands KW - Livestock KW - Grazing KW - Water Resources KW - Environmental Justice KW - Socioeconomic Assessments KW - Water Treatment KW - Irrigation KW - Soils KW - Waste Disposal KW - Air Quality KW - Harvest KW - Land Use KW - Vegetation KW - Wetlands KW - United States KW - Clean Air Act Amendments of 1990, Emission Standards KW - Executive Order 12898, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16393956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2015-01-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=PROPOSED+RULE%3A+STANDARDS+FOR+GROWING%2C+HARVESTING%2C+PACKING%2C+AND+HOLDING+OF+PRODUCE+FOR+HUMAN+CONSUMPTION.&rft.title=PROPOSED+RULE%3A+STANDARDS+FOR+GROWING%2C+HARVESTING%2C+PACKING%2C+AND+HOLDING+OF+PRODUCE+FOR+HUMAN+CONSUMPTION.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, Food and Drug Administration, College Park, Maryland N1 - Date revised - 2016-02-25 N1 - SuppNotes - Draft. Preparation date: January 16, 2015 N1 - Last updated - 2016-02-26 ER - TY - JOUR T1 - A novel family 19 chitinase from the marine-derived Pseudoalteromonas tunicata CCUG 44952T: Heterologous expression, characterization and antifungal activity AN - 1660404175; PQ0001069068 AB - The Ptchi19 gene of the marine Pseudoalteromonas tunicata CCUG 44952T was cloned and expressed in Escherichia coli. The recombinant chitinase PtChi19p of 483 amino acids has a molecular weight of 53.5 kDa and a multi-domain structure characteristic of family 19 chitinases. The relevant constituents of this multi-domain structure are the domain (D super(132)-A super(155)) where the active site is located, and the domain (A super(437)-W super(479)) that includes a C-terminal carbohydrate-binding module 5. The purified protein was active in the temperature range of 20-50 degree C and at pH values of 6-9.5, maintaining a high stability under suboptimal conditions and in the presence of different metal ions. The recombinant enzyme hydrolyzed colloidal and crystalline chitin, as well as p-NP N-acetyl- beta -d-glucosaminide. As PtChi19p exhibited antifungal activity against phytopathogenic and human pathogenic fungi, it could be used as an alternative biofungicide. JF - Biochemical Engineering Journal AU - Garcia-Fraga, Belen AU - Silva, Abigail Fda AU - Lopez-Seijas, Jacobo AU - Sieiro, Carmen Y1 - 2015/01/15/ PY - 2015 DA - 2015 Jan 15 SP - 84 EP - 93 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 93 SN - 1369-703X, 1369-703X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA Marine Biotechnology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Pseudoalteromonas tunicata KW - Family 19 glycosyl hydrolase KW - Enzyme biocatalysis KW - Recombinant DNA KW - Purification KW - Enzyme activity KW - Temperature effects KW - Metals KW - Ions KW - Chitinase KW - Amino acids KW - Fungi KW - Chitin KW - Enzymes KW - Molecular weight KW - Antifungal activity KW - Escherichia coli KW - pH effects KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03330:Biochemistry KW - Q4 27760:Microorganisms KW - J 02420:Plant Diseases KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660404175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Engineering+Journal&rft.atitle=A+novel+family+19+chitinase+from+the+marine-derived+Pseudoalteromonas+tunicata+CCUG+44952T%3A+Heterologous+expression%2C+characterization+and+antifungal+activity&rft.au=Garcia-Fraga%2C+Belen%3BSilva%2C+Abigail+Fda%3BLopez-Seijas%2C+Jacobo%3BSieiro%2C+Carmen&rft.aulast=Garcia-Fraga&rft.aufirst=Belen&rft.date=2015-01-15&rft.volume=93&rft.issue=&rft.spage=84&rft.isbn=&rft.btitle=&rft.title=Biochemical+Engineering+Journal&rft.issn=1369703X&rft_id=info:doi/10.1016%2Fj.bej.2014.09.014 L2 - http://www.sciencedirect.com/science/article/pii/S1369703X14002836 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-06-22 N1 - SubjectsTermNotLitGenreText - Temperature effects; Ions; Metals; Amino acids; Chitinase; Fungi; Molecular weight; Antifungal activity; Chitin; Enzymes; pH effects; Pseudoalteromonas tunicata; Escherichia coli DO - http://dx.doi.org/10.1016/j.bej.2014.09.014 ER - TY - JOUR T1 - Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells. AN - 1652396527; 25586472 AB - Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 and STAT5B in NK/T-cell lymphomas (n=51), γδ-T-cell lymphomas (n=43) and their cell lines (n=9) through next generation and/or Sanger sequencing. STAT5B N642H is particularly frequent in all forms of γδ-T-cell lymphomas. STAT3 and STAT5B mutations are associated with increased phosphorylated protein and a growth advantage to transduced cell lines or normal NK cells. Growth-promoting activity of the mutants can be partially inhibited by a JAK1/2 inhibitor. Molecular modelling and surface plasmon resonance measurements of the N642H mutant indicate a marked increase in binding affinity of the phosphotyrosine-Y699 with the mutant histidine. This is associated with the prolonged persistence of the mutant phosphoSTAT5B and marked increase of binding to target sites. Our findings suggest that JAK-STAT pathway inhibition may represent a therapeutic strategy. JF - Nature communications AU - Küçük, Can AU - Jiang, Bei AU - Hu, Xiaozhou AU - Zhang, Wenyan AU - Chan, John K C AU - Xiao, Wenming AU - Lack, Nathan AU - Alkan, Can AU - Williams, John C AU - Avery, Kendra N AU - Kavak, Pınar AU - Scuto, Anna AU - Sen, Emel AU - Gaulard, Philippe AU - Staudt, Lou AU - Iqbal, Javeed AU - Zhang, Weiwei AU - Cornish, Adam AU - Gong, Qiang AU - Yang, Qunpei AU - Sun, Hong AU - d'Amore, Francesco AU - Leppä, Sirpa AU - Liu, Weiping AU - Fu, Kai AU - de Leval, Laurence AU - McKeithan, Timothy AU - Chan, Wing C AD - Department of Pathology, City of Hope Medical Center, Duarte, California 91010, USA. ; Department of Pathology, West China Hospital of Sichuan University, Chengdu 610041, China. ; Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Food and Drug Administration, Maryland 20993, USA. ; Department of Pharmacology, Koc University, Istanbul 34450, Turkey. ; Department of Computer Engineering, Bilkent University, Ankara 06800, Turkey. ; Department of Molecular Medicine, Beckman Research Institute of City of Hope, Duarte, California 91010, USA. ; Department of Computer Engineering, Boğaziçi University, İstanbul 34342, Turkey. ; Département de Pathologie, Groupe Henri-Mondor Albert-Chenevier, Inserm U955, Université Paris Est, Créteil 94000, France. ; Molecular Biology of Lymphoid Malignancies Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. ; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA. ; Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska 68198-5805, USA. ; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China. ; Department of Hematology, Aarhus University Hospital, Aarhus 8000, Denmark. ; Department of Oncology, Helsinki University Central Hospital, PO Box 180, Helsinki 00029, Finland. ; Pathologie Clinique Institut, Universitaire de Pathologie rue du Bugnon 25, CH 1011 Lausanne, Switzerland. Y1 - 2015/01/14/ PY - 2015 DA - 2015 Jan 14 SP - 6025 VL - 6 KW - IL2 protein, human KW - 0 KW - Interleukin-2 KW - Receptors, Antigen, T-Cell, gamma-delta KW - STAT3 Transcription Factor KW - STAT3 protein, human KW - STAT5 Transcription Factor KW - STAT5B protein, human KW - Phosphotyrosine KW - 21820-51-9 KW - Histidine KW - 4QD397987E KW - JAK1 protein, human KW - EC 2.7.10.2 KW - Janus Kinase 1 KW - Index Medicus KW - Histidine -- chemistry KW - Janus Kinase 1 -- metabolism KW - Interleukin-2 -- metabolism KW - Phosphotyrosine -- chemistry KW - Humans KW - HEK293 Cells KW - Receptors, Antigen, T-Cell, gamma-delta -- metabolism KW - Protein Structure, Tertiary KW - Mutation KW - Binding Sites KW - T-Lymphocyte Subsets -- cytology KW - Gene Expression Regulation, Neoplastic KW - STAT5 Transcription Factor -- genetics KW - STAT3 Transcription Factor -- genetics KW - Killer Cells, Natural -- cytology KW - Lymphoma, T-Cell -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652396527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+communications&rft.atitle=Activating+mutations+of+STAT5B+and+STAT3+in+lymphomas+derived+from+%CE%B3%CE%B4-T+or+NK+cells.&rft.au=K%C3%BC%C3%A7%C3%BCk%2C+Can%3BJiang%2C+Bei%3BHu%2C+Xiaozhou%3BZhang%2C+Wenyan%3BChan%2C+John+K+C%3BXiao%2C+Wenming%3BLack%2C+Nathan%3BAlkan%2C+Can%3BWilliams%2C+John+C%3BAvery%2C+Kendra+N%3BKavak%2C+P%C4%B1nar%3BScuto%2C+Anna%3BSen%2C+Emel%3BGaulard%2C+Philippe%3BStaudt%2C+Lou%3BIqbal%2C+Javeed%3BZhang%2C+Weiwei%3BCornish%2C+Adam%3BGong%2C+Qiang%3BYang%2C+Qunpei%3BSun%2C+Hong%3Bd%27Amore%2C+Francesco%3BLepp%C3%A4%2C+Sirpa%3BLiu%2C+Weiping%3BFu%2C+Kai%3Bde+Leval%2C+Laurence%3BMcKeithan%2C+Timothy%3BChan%2C+Wing+C&rft.aulast=K%C3%BC%C3%A7%C3%BCk&rft.aufirst=Can&rft.date=2015-01-14&rft.volume=6&rft.issue=&rft.spage=6025&rft.isbn=&rft.btitle=&rft.title=Nature+communications&rft.issn=2041-1723&rft_id=info:doi/10.1038%2Fncomms7025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-08 N1 - Date created - 2015-01-14 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - SRA200820; SRA N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/ncomms7025 ER - TY - JOUR T1 - The role of colonic bacteria in the metabolism of the natural isoflavone daidzin to equol. AN - 1652388556; 25594250 AB - Isoflavones are found in leguminous plants, especially soybeans. They have a structural similarity to natural estrogens, which enables them to bind to estrogen receptors and elicit biological activities similar to natural estrogens. They have been suggested to be beneficial for the prevention and therapy of hormone-dependent diseases. After soy products are consumed, the bacteria of the intestinal microflora metabolize isoflavones to metabolites with altered absorption, bioavailability, and estrogenic characteristics. Variations in the effect of soy products have been correlated with the isoflavone metabolites found in plasma and urine samples of the individuals consuming soy products. The beneficial effects of the soy isoflavone daidzin, the glycoside of daidzein, have been reported in individuals producing equol, a reduction product of daidzein produced by specific colonic bacteria in individuals called equol producers. These individuals comprise 30% and 60% of populations consuming Western and soy-rich Asian diets, respectively. Since the higher percentage of equol producers in populations consuming soy-rich diets is correlated with a lower incidence of hormone-dependent diseases, considerable efforts have been made to detect the specific colonic bacteria involved in the metabolism of daidzein to the more estrogenic compound, equol, which should facilitate the investigation of the metabolic activities related to this compound. JF - Metabolites AU - Rafii, Fatemeh AD - Division of Microbiology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA. Fatemeh.Rafii@fda.hhs.gov. Y1 - 2015/01/14/ PY - 2015 DA - 2015 Jan 14 SP - 56 EP - 73 VL - 5 IS - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652388556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolites&rft.atitle=The+role+of+colonic+bacteria+in+the+metabolism+of+the+natural+isoflavone+daidzin+to+equol.&rft.au=Rafii%2C+Fatemeh&rft.aulast=Rafii&rft.aufirst=Fatemeh&rft.date=2015-01-14&rft.volume=5&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Metabolites&rft.issn=&rft_id=info:doi/10.3390%2Fmetabo5010056 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-17 N1 - Date created - 2015-01-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3390/metabo5010056 ER - TY - JOUR T1 - Aptamer-Based Detection of Disease Biomarkers in Mouse Models for Chagas Drug Discovery AN - 1660391667; PQ0001041743 AB - Drug discovery initiatives, aimed at Chagas treatment, have been hampered by the lack of standardized drug screening protocols and the absence of simple pre-clinical assays to evaluate treatment efficacy in animal models. In this study, we used a simple Enzyme Linked Aptamer (ELA) assay to detect T. cruzi biomarker in blood and validate murine drug discovery models of Chagas disease. In two mice models, Apt-29 ELA assay demonstrated that biomarker levels were significantly higher in the infected group compared to the control group, and upon Benznidazole treatment, their levels reduced. However, biomarker levels in the infected treated group did not reduce to those seen in the non-infected treated group, with 100% of the mice above the assay cutoff, suggesting that parasitemia was reduced but cure was not achieved. The ELA assay was capable of detecting circulating biomarkers in mice infected with various strains of T. cruzi parasites. Our results showed that the ELA assay could detect residual parasitemia in treated mice by providing an overall picture of the infection in the host. They suggest that the ELA assay can be used in drug discovery applications to assess treatment efficacy in-vivo. A marked decrease in incidence of Chagas Disease has been observed in the last decade achieved by vector control strategies; however, there are still geographical areas where the disease reaches endemic proportions. Due to high morbidity and disease burden, other avenues of Chagas control, such as vaccines and therapeutic agents need to be employed for comprehensive disease control and mitigation. As there are no vaccines available currently, two drugs (Benznidazole and Nifurtimox) have been the mainstay of treatment. However, these drugs produce multiple side effects and frequently lead to early termination of the treatment. In this study, we have successfully developed a new method to evaluate the presence of Chagas biomarkers in the plasma of infected drug treated mice. Our study shows that high biomarker levels in T. cruzi infected mice, after drug treatment, can indicate treatment failure. Our assay provides a global picture of parasitemia in the host and a positive result would thus suggest that the treated animals continue to harbor T. cruzi parasites somewhere in the body. This study provides a new method to test for T. cruzi infection and for assessing the effectiveness of treatment. JF - PLoS Neglected Tropical Diseases AU - de Araujo, Fernanda Fortes AU - Nagarkatti, Rana AU - Gupta, Charu AU - Marino, Ana Paula AU - Debrabant, Alain AD - Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, United States of America Y1 - 2015/01/08/ PY - 2015 DA - 2015 Jan 08 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 9 IS - 1 SN - 1935-2727, 1935-2727 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Aptamers KW - Parasites KW - Animal models KW - Disease control KW - Biomarkers KW - Hosts KW - Drug screening KW - Infection KW - Morbidity KW - Public health KW - Disease transmission KW - Drug discovery KW - Disease detection KW - Drugs KW - Vectors KW - Enzymes KW - biomarkers KW - nifurtimox KW - Blood KW - parasitemia KW - Benznidazole KW - Vaccines KW - Side effects KW - Chagas' disease KW - K 03410:Animal Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660391667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Aptamer-Based+Detection+of+Disease+Biomarkers+in+Mouse+Models+for+Chagas+Drug+Discovery&rft.au=de+Araujo%2C+Fernanda+Fortes%3BNagarkatti%2C+Rana%3BGupta%2C+Charu%3BMarino%2C+Ana+Paula%3BDebrabant%2C+Alain&rft.aulast=de+Araujo&rft.aufirst=Fernanda&rft.date=2015-01-08&rft.volume=9&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0003451 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Parasites; Disease control; Disease detection; Vaccines; Hosts; Biomarkers; Drugs; Disease transmission; Public health; Aptamers; Animal models; Enzymes; Vectors; Infection; Drug screening; biomarkers; Morbidity; Blood; nifurtimox; Drug discovery; parasitemia; Benznidazole; Side effects; Chagas' disease DO - http://dx.doi.org/10.1371/journal.pntd.0003451 ER - TY - JOUR T1 - Determination of Phosphodiesterase-5 Inhibitors and Analogs Using High-Performance Liquid Chromatography with Ultraviolet Detection AN - 1823944679; PQ0001720257 AB - A considerable number of erectile dysfunction products, and dietary supplements suspected of containing phosphodiesterase-5 (PDE-5) inhibitors, have been analyzed by the US Food and Drug Administration. Often these samples are found to contain the approved active pharmaceutical ingredients (APIs) such as sildenafil, tadalafil or vardenafil. However, analogs of these APIs have also been identified in many samples and products containing multiple PDE-5 inhibitors have also been found. A single high-performance liquid chromatography with ultraviolet detection method has been developed for the determination of sildenafil, tadalafil, vardenafil and a number of commonly encountered analogs in pharmaceutical dosage forms and dietary supplement products, including tablets, capsules, bulk powders, troches and liquids. This method was designed as an alternative to methods developed for the determination of a single PDE-5 inhibitor. Using this protocol, 14 PDE-5 inhibitor compounds can be separated and determined in a single analysis. JF - Journal of Chromatographic Science AU - Nickum, Elisa A AU - Flurer, Cheryl L AD - U.S. Food and Drug Administration, Forensic Chemistry Center, 6751 Steger Drive, Cincinnati, OH 45237, USA, elisa.nickum@fda.hhs.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 38 EP - 46 PB - Preston Publications, Inc., 6600 W. Touhy Ave. Niles IL 60714 United States VL - 53 IS - 1 SN - 0021-9665, 0021-9665 KW - Toxicology Abstracts KW - High-performance liquid chromatography KW - Powder KW - U.V. radiation KW - Dietary supplements KW - Tablets KW - Pharmaceuticals KW - Sildenafil KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1823944679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Chromatographic+Science&rft.atitle=Determination+of+Phosphodiesterase-5+Inhibitors+and+Analogs+Using+High-Performance+Liquid+Chromatography+with+Ultraviolet+Detection&rft.au=Nickum%2C+Elisa+A%3BFlurer%2C+Cheryl+L&rft.aulast=Nickum&rft.aufirst=Elisa&rft.date=2015-01-01&rft.volume=53&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Journal+of+Chromatographic+Science&rft.issn=00219665&rft_id=info:doi/10.1093%2Fchromsci%2Fbmu010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-09-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Powder; U.V. radiation; Dietary supplements; Tablets; Pharmaceuticals; Sildenafil DO - http://dx.doi.org/10.1093/chromsci/bmu010 ER - TY - JOUR T1 - Pressure drop of filtering facepiece respirators: How low should we go? AN - 1811885201; PQ0003508347 AB - Introduction: This study was undertaken to determine the mean peak filter resistance to airflow (Rfilter) encountered by subjects while wearing prototype filtering facepiece respirators (PRs) with low Rfilter during nasal and oral breathing at sedentary and low-moderate work rates. Material and methods: In-line pressure transducer measurements of mean Rfilteracross PRs with nominal Rfilter of 29.4 Pa, 58.8 Pa and 88.2 Pa (measured at 85 l/min constant airflow) were obtained during nasal and oral breathing at sedentary and low-moderate work rates for 10 subjects. Results: The mean Rfilter for the 29.4 PR was significantly lower than the other 2 PRs (p 0.05). The mean Rfilter was greater for oral versus nasal breathing and for exercise compared to sedentary activity (p < 0.001). Conclusions: Mean oral and nasal Rfilter for all 3 PRs was at, or below, the minimal threshold level for detection of inspiratory resistance (the 58.8-74.5 Pa/lxs-1), which may account for the previously-reported lack of significant subjective or physiological differences when wearing PRs with these low Rfilter. Lowering filtering facepiece respirator Rfilter below 88.2 Pa (measured at 85 l/min constant airflow) may not result in additional subjective or physiological benefit to the wearer. JF - International Journal of Occupational Medicine and Environmental Health AU - Kim, Jung-Hyun AU - Roberge, Raymond J AU - Powell, Jeffrey B AU - Shaffer, Ronald E AU - Ylitalo, Caroline M AU - Sebastian, John M AD - Centers for Disease Control and Prevention, Pittsburgh, Pennsylvania, United States of America (National Institute for Occupational Safety and Health, National Personal Protective Technology Laboratory, Technology Research Branch) Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 71 EP - 80 PB - Nofer Institute of Occupational Medicine, Ul Sw Teresy 0 Lodz 90950 Poland VL - 28 IS - 1 SN - 1232-1087, 1232-1087 KW - Health & Safety Science Abstracts KW - respirator KW - filter KW - oral breathing KW - nasal breathing KW - Filters KW - Transducers KW - Prototypes KW - Physiology KW - Respirators KW - Protective equipment KW - Air flow KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1811885201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Occupational+Medicine+and+Environmental+Health&rft.atitle=Pressure+drop+of+filtering+facepiece+respirators%3A+How+low+should+we+go%3F&rft.au=Kim%2C+Jung-Hyun%3BRoberge%2C+Raymond+J%3BPowell%2C+Jeffrey+B%3BShaffer%2C+Ronald+E%3BYlitalo%2C+Caroline+M%3BSebastian%2C+John+M&rft.aulast=Kim&rft.aufirst=Jung-Hyun&rft.date=2015-01-01&rft.volume=28&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Occupational+Medicine+and+Environmental+Health&rft.issn=12321087&rft_id=info:doi/10.13075%2Fijomeh.1896.00153 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-08-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Filters; Transducers; Prototypes; Physiology; Respirators; Protective equipment; Air flow DO - http://dx.doi.org/10.13075/ijomeh.1896.00153 ER - TY - GEN T1 - A Resource Guide for Head Start Programs: Moving beyond a Culture of Compliance to a Culture of Continuous Improvement. OPRE Report 2015-02 AN - 1773223074; ED558548 AB - Head Start has long focused on assessing and improving program quality to ensure that the children served receive the best possible preparation for school and life. Most research has been focused inside the classroom--the classroom environment, teacher qualifications, and teacher interactions. Of course, the classroom is important because that is where children spend most of their time, but what is done in the classroom isn't entirely--or primarily--the teacher's decision. The management and leadership of the program typically make the decisions about which curriculum and assessments to use, the equipment and materials to provide, and how to interact with the children. Thus, it is important to study, understand, and provide guidance for those managers and leaders in their decisions. Accordingly, the Office of Planning, Research and Evaluation (OPRE) contracted with the Urban Institute in 2012 to conduct the Head Start Leadership, Excellence, and Data Systems (LEADS) project. The LEADS project's goal is to understand the factors in organizational and management systems that promote effective early childhood education practices and outcomes. The LEADS project has three primary products: (1) a literature review and conceptual framework drawing from the work of other disciplines that have studied data use for quality improvement; (2) documentation of promising practices in Head Start programs around data use for continuous quality improvement; and (3) this resource guide to translate the research into information community-based Head Start programs can use. The purpose of this resource guide is to help leadership, management, supervisory, and data-focused staff in Head Start and Early Head Start programs: (1) understand how data, including the data they already collect, can help them achieve their program goals; (2) learn techniques for fostering a culture of learning in their organization; and (3) increase their ability to identify and address gaps and continuously improve their programs. This document provides guidance on enhancing data use for quality improvement by drawing upon LEADS project research on data use in other fields, promising practices observed in Head Start programs, and existing Head Start technical assistance and training materials. Fostering data use and a learning culture is hard work; it helps to have multiple resources from which to draw. The following are appended: (1) Aligning this Resource Guide with Existing Head Start National Center Program Management and Fiscal Operations (PMFO) Technical Assistance Materials; (2) Continuous Quality Improvement: Conceptual Framework; (3) Head Start Frameworks for Continuous Program Improvement; and (4) Resource List. AU - Derrick-Mills, Teresa AU - Winkler, Mary K. AU - Healy, Olivia AU - Greenberg, Erica Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 85 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Early Childhood Education KW - Stakeholders KW - Program Effectiveness KW - Educational Objectives KW - Low Income KW - Guidelines KW - Educational Improvement KW - Holistic Approach KW - Program Improvement KW - Educational Development KW - Best Practices KW - Information Utilization KW - Federal Programs KW - Staff Utilization KW - Disadvantaged Youth KW - Data Collection KW - Compliance (Legal) KW - Data Analysis KW - Preschool Children KW - School Readiness KW - Educational Quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773223074?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Portfolio of Research in Welfare and Family Self-Sufficiency: FY 2014. OPRE Report 2015-15 AN - 1773221725; ED558550 AB - The Division of Economic Independence within the Office of Planning, Research and Evaluation (OPRE) has primary responsibility for welfare and family self-sufficiency research. OPRE's research in the area of welfare and family self-sufficiency is designed to expand knowledge about effective programs to promote employment, self-sufficiency, and economic well-being among low-income families. Research focuses on four major areas: (1) Temporary Assistance for Needy Families (TANF) and the Safety Net; (2) Employment and the Labor Market; (3) Education and Training; and (4) Other and Cross-Cutting Research. Within these areas, OPRE funds experimental impact evaluations, implementation evaluations, and descriptive research projects aimed at informing the design and implementation of programs. OPRE also invests in activities to disseminate rigorous research on welfare and family self-sufficiency topics. This portfolio describes major welfare and family self-sufficiency research projects sponsored by OPRE in Fiscal Year 2014. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 27 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Temporary Assistance for Needy Families KW - ERIC, Resources in Education (RIE) KW - Postsecondary Education KW - Adult Education KW - Low Income Groups KW - Well Being KW - Federal Programs KW - Research Projects KW - Welfare Services KW - Labor Market KW - Employment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221725?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Services for Families of Infants and Toddlers Experiencing Trauma. A Research-to-Practice Brief. OPRE Report 2015-14 AN - 1773221645; ED558495 AB - Infancy is a time of extreme opportunity, but it is also a time of extreme vulnerability, particularly for those reared in high-risk environments. Although infant exposure to any risk is important to understand, this brief focuses on the experience and impact of "trauma," defined as witnessing or experiencing an event that poses a real or perceived threat. Beginning life in the context of trauma places infants and toddlers on a compromised developmental path. Because of this, the impact of trauma on infants and toddlers can be particularly harmful. On the other hand, the developmental plasticity (i.e., the potential for developmental change in response to the environment) during this early period of life may allow infants and toddlers to rebound from these traumatic experiences, particularly if they experience "stable, nurturing caregiving." The author briefly summarizes what is known about the impact of trauma on infants and toddlers, and the intervention strategies that could potentially protect them from the adverse consequences of traumatic experiences. She focuses on interventions that support parents in providing the stable and nurturing caregiving that is responsive to the child's general developmental needs and that promotes children's sense of safety and security. Such interventions may reduce or provide a buffer against infants' traumatic experiences. Finally, the author considers how child care, Early Head Start, home visitation, and child welfare can become trauma-informed infant/toddler service delivery systems. AU - Harden, Branda Jones Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 16 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Toddlers KW - Parent Role KW - Delivery Systems KW - Intervention KW - Child Care KW - Child Welfare KW - Psychological Patterns KW - Parent Child Relationship KW - Child Rearing KW - Child Development KW - At Risk Persons KW - Family Environment KW - Home Visits KW - Mental Health KW - Child Safety KW - Screening Tests KW - Trauma KW - Family Counseling KW - Counseling Techniques KW - Psychotherapy KW - Family Programs KW - Early Intervention KW - Attachment Behavior KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773221645?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - GEN T1 - The Mother and Infant Home Visiting Program Evaluation: Early Findings on the Maternal, Infant, and Early Childhood Home Visiting Program. A Report to Congress. OPRE Report 2015-11 AN - 1773213413; ED558512 AB - "The Mother and Infant Home Visiting Program Evaluation: Early Findings on the Maternal, Infant, and Early Childhood Home Visiting Program--A Report to Congress" presents the first findings from the Mother and Infant Home Visiting Program Evaluation (MIHOPE), the legislatively mandated national evaluation of the Maternal, Infant, and Early Childhood Home Visiting program (MIECHV or the Home Visiting Program). The report includes an analysis of the states' needs assessments, as well as baseline characteristics of families, staff, local programs, and models participating in the study. The information in this report provides a foundation for understanding the implementation and impacts of MIECHV-funded home visiting programs. Later reports will explore the local and national implementation of those programs, and their effects on families with young children. The study is being overseen by OPRE and conducted by MDRC in partnership with James Bell Associates, Johns Hopkins University, Mathematica Policy Research, the University of Georgia, and Columbia University. The study's design and plans for the content of the Report to Congress reflect advice from the Secretary's Advisory Committee on the Maternal, Infant and Early Childhood Home Visiting Program Evaluation. The following are appended: (1) Home Visiting Programs in Existence Before MIECHV, as Reported in the 2010 State Needs Assessments; (2) Programs in Use in Only One State Prior to MIECHV, as Reported in the 2010 State Needs Assessments; (3) Indicators of Community Risk in Communities Chosen for MIECHV Funding, Based on the 2010 State Needs Assessments; (4) Fiscal Year 2010 and 2011 State Plans for MIECHV Funding; and (5) Chapter 5 Supplement: Additional Information on the Home Visiting Implementation Policies of National Models and Local Programs. AU - Michalopoulos, Charles AU - Lee, Helen AU - Duggan, Anne AU - Lundquist, Erika AU - Tso, Ada AU - Crowne, Sarah Shea AU - Burrell, Lori AU - Somers, Jennifer AU - Filene, Jill H. AU - Knox, Virginia Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 488 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - California KW - Georgia KW - Illinois KW - Iowa KW - Kansas KW - Michigan KW - Nevada KW - New Jersey KW - Pennsylvania KW - South Carolina KW - Washington KW - Wisconsin KW - ERIC, Resources in Education (RIE) KW - Program Descriptions KW - Family Characteristics KW - Federal Legislation KW - Federal Programs KW - Program Implementation KW - Mothers KW - Home Visits KW - Early Intervention KW - Program Evaluation KW - Needs Assessment KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773213413?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Effects of grazing, nutrients, and depth on the ciguatera-causing dinoflagellate Gambierdiscus in the US Virgin Islands AN - 1762365201; PQ0002505674 AB - Ciguatera fish poisoning in humans is a serious and widespread syndrome associated with the consumption of reef fishes that have accumulated lipid-soluble toxins known as ciguatoxins. These toxins are piscine metabolites of ciguatoxin precursors produced by benthic dinoflagellates in the genus Gambierdiscus. This investigation employed a novel experimental approach to identify and characterize the environmental factors and their interactions that influence the dynamic balance between cellular growth and loss of Gambierdiscus populations in situ. Field studies were conducted in St. Thomas (US Virgin Islands) at 3 sites and 2 depths (10 and 20 m). At each site and depth, Gambierdiscus was subjected to treatments designed to reduce grazing pressure (disturbance and removal) and elevate nutrient availability to elicit a population abundance response attributable to one of these treatments. We hypothesized that Gambierdiscus abundance would respond positively to increased nutrient availability, increasing depth (reduced water motion), and decreased grazing pressures. We found communities of Gambierdiscus were significantly higher by, on average, 138% when the effects of grazing were limited (p = 0.0002). Among sites, the effects of depth and nutrients on Gambierdiscus populations were not significant. The significant effect of grazing and disturbance observed in this study suggests that changes in reef herbivore and detritivore feeding selectivity and grazing rates may have large impacts on the areal density of Gambierdiscus in natural systems. Whether or not reduced grazing rates or disturbances translate into higher cell (toxin) ingestion rates for consumers and ultimately cause changes in toxicity for humans is unknown and in need of further investigation. JF - Marine Ecology Progress Series AU - Loeffler, Christopher R AU - Richlen, Mindy L AU - Brandt, Marilyn E AU - Smith, Tyler B AD - Center for Marine and Environmental Studies, University of the Virgin Islands, 2 John Brewers Bay, St Thomas, US Virgin Islands 00802, USA, christopher.loeffler@fda.hhs.gov Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 91 EP - 104 PB - Inter-Research, Nordbuente 23 Oldendorf/Luhe 21385 Germany VL - 531 SN - 0171-8630, 0171-8630 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources; Ecology Abstracts KW - Ciguatera fish poisoning KW - Gambierdiscus KW - Caging KW - Grazing KW - St. Thomas KW - Coral reefs KW - Fish survey KW - Management KW - Reefs KW - ASW, Caribbean Sea, Lesser Antilles, US Virgin Is. KW - Toxicants KW - Abundance KW - Phytoplankton KW - Metabolites KW - Nutrients KW - Environmental factors KW - Growth KW - Islands KW - Feeding behaviour KW - Dinoflagellates KW - Consumers KW - detritivores KW - Pressure KW - Marine KW - Feeding KW - Nutrient availability KW - Poisoning KW - Environmental impact KW - Toxicity KW - Toxins KW - Ecosystem disturbance KW - Ciguatera KW - Herbivores KW - Food preferences KW - Ciguatoxin KW - O 5080:Legal/Governmental KW - D 04040:Ecosystem and Ecology Studies KW - K 03450:Ecology KW - Q1 08567:Fishery oceanography and limnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1762365201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Marine+Ecology+Progress+Series&rft.atitle=Effects+of+grazing%2C+nutrients%2C+and+depth+on+the+ciguatera-causing+dinoflagellate+Gambierdiscus+in+the+US+Virgin+Islands&rft.au=Loeffler%2C+Christopher+R%3BRichlen%2C+Mindy+L%3BBrandt%2C+Marilyn+E%3BSmith%2C+Tyler+B&rft.aulast=Loeffler&rft.aufirst=Christopher&rft.date=2015-01-01&rft.volume=531&rft.issue=&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Marine+Ecology+Progress+Series&rft.issn=01718630&rft_id=info:doi/10.3354%2Fmeps11310 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Growth; Toxicants; Feeding behaviour; Grazing; Environmental impact; Phytoplankton; Ciguatoxin; Food preferences; Ecosystem disturbance; Feeding; Reefs; Nutrient availability; Abundance; Poisoning; Nutrients; Metabolites; Toxicity; Environmental factors; Toxins; Ciguatera; Herbivores; Islands; Dinoflagellates; Consumers; Pressure; detritivores; Gambierdiscus; ASW, Caribbean Sea, Lesser Antilles, US Virgin Is.; Marine DO - http://dx.doi.org/10.3354/meps11310 ER - TY - JOUR T1 - Identifying Similar Cases in Document Networks Using Cross-Reference Structures AN - 1753470812; PQ0002431018 AB - Our objective was to explore the creation of document networks based on different thresholds of shared information and different clustering algorithms on those networks to identify document clusters describing similar clinical cases. We created networks from vaccine adverse event report sets using seven approaches for linking reports. We then applied three clustering algorithms [visualization of similarities (VOS), Louvain, k-means] to these networks and evaluated their ability to identify known clusters. The report sets included one simulated set and three sets from the Vaccine Adverse Event Reporting System; each was split into training and testing subsets. Training subsets were used to estimate parameter values for the clustering algorithms and testing subsets to evaluate clusters. We created the networks by linking reports based on shared information in the form either of individual Medical Dictionary for Regulatory Activities Preferred Terms (PTs) or of dyads, triplets, quadruplets, quintuplets, and sextuplets of PTs; we created another network by weighting the single PT network connections by Lin's information theoretic approach to similarity. We then repeated this entire process using networks based on text mining output rather than structured data. We evaluated report clustering using recall, precision, and f-measure. The VOS algorithm outperformed Louvain and k-means in general. The best weighting scheme appeared to be related to the complexity of the known cluster. For example, singleton weighting performed best for an intussusception cluster driven by a single PT. We observed marginal differences between the code- and textual-based clustering. In conclusion, our approach supported identification of similar nodes in a document network. JF - IEEE Journal of Biomedical and Health Informatics AU - Botsis, Taxiarchis AU - Scott, John AU - Woo, Emily Jane AU - Ball, Robert AD - Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, MD, USA PY - 2015 SP - 1906 EP - 1917 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 United States VL - 19 IS - 6 SN - 2168-2194, 2168-2194 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Informatics KW - intussusception KW - Algorithms KW - Vaccines KW - Nodes KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753470812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Journal+of+Biomedical+and+Health+Informatics&rft.atitle=Identifying+Similar+Cases+in+Document+Networks+Using+Cross-Reference+Structures&rft.au=Botsis%2C+Taxiarchis%3BScott%2C+John%3BWoo%2C+Emily+Jane%3BBall%2C+Robert&rft.aulast=Botsis&rft.aufirst=Taxiarchis&rft.date=2015-01-01&rft.volume=19&rft.issue=6&rft.spage=1906&rft.isbn=&rft.btitle=&rft.title=IEEE+Journal+of+Biomedical+and+Health+Informatics&rft.issn=21682194&rft_id=info:doi/10.1109%2FJBHI.2014.2345873 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Data processing; Informatics; intussusception; Algorithms; Vaccines; Nodes DO - http://dx.doi.org/10.1109/JBHI.2014.2345873 ER - TY - JOUR T1 - Modern analytics for synthetically derived complex drug substances: NMR, AFFF-MALS, and MS tests for glatiramer acetate AN - 1751215798; PQ0002364437 AB - Glatiramer acetate (GA) is a mixture of synthetic copolymers consisting of four amino acids (glutamic acid, lysine, alanine, and tyrosine) with a labeled molecular weight range of 5000 to 9000 Da. GA is marketed as Copaxone(TM) by Teva for the treatment of multiple sclerosis. Here, the agency has evaluated the structure and composition of GA and a commercially available comparator, Copolymer-1. Modern analytical technologies which can characterize these complex mixtures are desirable for analysis of their comparability and structural "sameness." In the studies herein, a molecular fingerprinting approach is taken using mass-accurate mass spectrometry (MS) analysis, nuclear magnetic resonance (NMR) (1D- super(1)H-NMR, 1D- super(13)C-NMR, and 2D NMR), and asymmetric field flow fractionation (AFFF) coupled with multi-angle light scattering (MALS) for an in-depth characterization of three lots of the marketplace drug and a formulated sample of the comparator. Statistical analyses were applied to the MS and AFFF-MALS data to assess these methods' ability to detect analytical differences in the mixtures. The combination of multiple orthogonal measurements by liquid chromatography coupled with MS (LC-MS), AFFF-MALS, and NMR on the same sample set was found to be fit for the intended purpose of distinguishing analytical differences between these complex mixtures of peptide chains. JF - Analytical and Bioanalytical Chemistry AU - Rogstad, Sarah AU - Pang, Eric AU - Sommers, Cynthia AU - Hu, Meng AU - Jiang, Xiaohui AU - Keire, David A AU - Boyne, Michael T AD - Division of Pharmaceutical Analysis, Office of Testing and Research, Center for Drug Evaluation and Research, US Food and Drug Administration, 645 S. Newstead Ave., St. Louis, MO, 63110, USA, david.keire@fda.hhs.gov PY - 2015 SP - 8647 EP - 8659 PB - Springer Science+Business Media, Berlin/Heidelberg Germany VL - 407 IS - 29 SN - 1618-2642, 1618-2642 KW - Water Resources Abstracts; Aqualine Abstracts KW - Testing Procedures KW - Mass Spectrometry KW - Amino Acids KW - Weight KW - Acids KW - Statistical Analysis KW - Liquid Chromatography KW - Drugs KW - AQ 00001:Water Resources and Supplies KW - SW 5010:Network design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1751215798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Modern+analytics+for+synthetically+derived+complex+drug+substances%3A+NMR%2C+AFFF-MALS%2C+and+MS+tests+for+glatiramer+acetate&rft.au=Rogstad%2C+Sarah%3BPang%2C+Eric%3BSommers%2C+Cynthia%3BHu%2C+Meng%3BJiang%2C+Xiaohui%3BKeire%2C+David+A%3BBoyne%2C+Michael+T&rft.aulast=Rogstad&rft.aufirst=Sarah&rft.date=2015-01-01&rft.volume=407&rft.issue=29&rft.spage=8647&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-015-9057-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 25 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Testing Procedures; Mass Spectrometry; Amino Acids; Weight; Acids; Statistical Analysis; Liquid Chromatography; Drugs DO - http://dx.doi.org/10.1007/s00216-015-9057-8 ER - TY - JOUR T1 - Infection of Murine Macrophages by Salmonella enterica Serovar Heidelberg Blocks Murine Norovirus Infectivity and Virus-induced Apoptosis. AN - 1750002704; 26658916 AB - Gastroenteritis caused by bacterial and viral pathogens constitutes a major public health threat in the United States accounting for 35% of hospitalizations. In particular, Salmonella enterica and noroviruses cause the majority of gastroenteritis infections, with emergence of sporadic outbreaks and incidence of increased infections. Although mechanisms underlying infections by these pathogens have been individually studied, little is known about the mechanisms regulating co-infection by these pathogens. In this study, we utilized RAW 264.7 murine macrophage cells to investigate the mechanisms governing co-infection with S. enterica serovar Heidelberg and murine norovirus (MNV). We demonstrate that infection of RAW 264.7 cells with S. enterica reduces the replication of MNV, in part by blocking virus entry early in the virus life cycle, and inducing antiviral cytokines later in the infection cycle. In particular, bacterial infection prior to, or during MNV infection affected virus entry, whereas MNV entry remained unaltered when the virus infection preceded bacterial invasion. This block in virus entry resulted in reduced virus replication, with the highest impact on replication observed during conditions of co-infection. In contrast, bacterial replication showed a threefold increase in MNV-infected cells, despite the presence of antibiotic in the medium. Most importantly, we present evidence that the infection of MNV-infected macrophages by S. enterica blocked MNV-induced apoptosis, despite allowing efficient virus replication. This apoptosis blockade was evidenced by reduction in DNA fragmentation and absence of poly-ADP ribose polymerase (PARP), caspase 3 and caspase 9 cleavage events. Our study suggests a novel mechanism of pathogenesis whereby initial co-infection with these pathogens could result in prolonged infection by either of these pathogens or both together. JF - PloS one AU - Agnihothram, Sudhakar S AU - Basco, Maria D S AU - Mullis, Lisa AU - Foley, Steven L AU - Hart, Mark E AU - Sung, Kidon AU - Azevedo, Marli P AD - Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 12 KW - Cytokines KW - 0 KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Virus Replication KW - Macrophages -- cytology KW - Animals KW - Macrophages -- microbiology KW - Macrophages -- virology KW - Cytokines -- metabolism KW - Mice KW - Virus Internalization KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Microscopy, Fluorescence KW - Cytokines -- analysis KW - Enzyme-Linked Immunosorbent Assay KW - Up-Regulation KW - DNA Fragmentation KW - Cell Line KW - Caspase 3 -- metabolism KW - Coinfection KW - Norovirus -- physiology KW - Norovirus -- pathogenicity KW - Salmonella enterica -- pathogenicity KW - Apoptosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1750002704?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Infection+of+Murine+Macrophages+by+Salmonella+enterica+Serovar+Heidelberg+Blocks+Murine+Norovirus+Infectivity+and+Virus-induced+Apoptosis.&rft.au=Agnihothram%2C+Sudhakar+S%3BBasco%2C+Maria+D+S%3BMullis%2C+Lisa%3BFoley%2C+Steven+L%3BHart%2C+Mark+E%3BSung%2C+Kidon%3BAzevedo%2C+Marli+P&rft.aulast=Agnihothram&rft.aufirst=Sudhakar&rft.date=2015-01-01&rft.volume=10&rft.issue=12&rft.spage=e0144911&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0144911 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-07-06 N1 - Date created - 2015-12-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Med Microbiol Immunol. 2006 Mar;195(1):11-9 [16086183] Curr Top Microbiol Immunol. 2014;385:327-56 [25027822] Pediatr Infect Dis J. 2006 Feb;25(2):160-4 [16462295] Infect Immun. 2006 May;74(5):2562-7 [16622191] J Virol. 2006 Jun;80(11):5104-12 [16698991] Vaccine. 2006 Jun 12;24(24):5220-34 [16650512] Biofactors. 1998;8(3-4):283-5 [9914830] J Virol. 1999 Apr;73(4):2650-7 [10074110] Exp Cell Res. 2001 Oct 1;269(2):193-201 [11570811] Microbes Infect. 2001 Nov-Dec;3(14-15):1321-6 [11755421] Antioxid Redox Signal. 2002 Oct;4(5):769-81 [12470504] Arch Pharm Res. 2002 Dec;25(6):895-902 [12510845] J Clin Invest. 1991 Aug;88(2):540-5 [1907615] Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6285-9 [1378624] J Gen Virol. 1993 Aug;74 ( Pt 8):1653-6 [8345356] J Gen Virol. 1994 Aug;75 ( Pt 8):1883-8 [8046390] Biochim Biophys Acta. 1998 Aug 10;1366(1-2):177-96 [9714796] PLoS Biol. 2004 Dec;2(12):e432 [15562321] J Biol Chem. 2005 Mar 11;280(10):9058-64 [15642738] J Infect. 2006 Dec;53(6):408-14 [16490255] Toxicol Pathol. 2007 Jun;35(4):495-516 [17562483] Emerg Infect Dis. 2008 Aug;14(8):1224-31 [18680645] PLoS Pathog. 2008 Dec;4(12):e1000236 [19079577] J Virol. 2009 Apr;83(8):3647-56 [19211757] J Appl Microbiol. 2009 Jul;107(1):65-71 [19298511] J Virol. 2011 Jan;85(1):231-42 [20980508] J Infect Dis. 2011 Mar 15;203(6):880-8 [21278211] Appl Environ Microbiol. 2011 Jul;77(13):4273-9 [21571882] Clin Infect Dis. 2011 Sep;53(6):568-71 [21832262] PLoS One. 2011;6(9):e24286 [21931672] Clin Microbiol Infect. 2011 Dec;17(12):1895-9 [21848976] J Vis Exp. 2012;(66):e4297 [22951568] Influenza Other Respir Viruses. 2013 Mar;7(2):168-76 [22487223] Am J Infect Control. 2013 Jul;41(7):654-7 [23266383] Emerg Infect Dis. 2013 Aug;19(8):1214-21 [23876432] Science. 2014 Nov 7;346(6210):755-9 [25378626] PLoS Med. 2015 Jan;12(1):e1001776 [25562317] J Clin Microbiol. 2015 Feb;53(2):373-81 [24989606] Curr Opin Microbiol. 2015 Feb;23:23-31 [25461569] ScientificWorldJournal. 2015;2015:520179 [25664339] Foodborne Pathog Dis. 2015 Jun;12(6):492-9 [26067228] Epidemiol Infect. 2015 Sep;143(12):2473-85 [25600652] Expert Rev Vaccines. 2015;14(9):1241-53 [26224658] Curr Opin Microbiol. 2006 Feb;9(1):102-8 [16406838] PLoS One. 2013;8(9):e72788 [24023773] PLoS One. 2013;8(10):e77866 [24098597] Microbiol Mol Biol Rev. 2013 Dec;77(4):582-607 [24296573] Nat Rev Microbiol. 2014 Apr;12(4):252-62 [24590244] Curr Protoc Microbiol. 2014;33:15K.2.1-61 [24789596] Clin Infect Dis. 2014 Jun;58(12):1746-52 [24585561] Cell Host Microbe. 2014 Jun 11;15(6):668-80 [24922570] Lancet Infect Dis. 2014 Aug;14(8):725-30 [24981041] J Virol. 2014 Aug;88(16):9277-86 [24899198] Cell Host Microbe. 2014 Aug 13;16(2):249-56 [25121752] J Gen Virol. 2014 Sep;95(Pt 9):1958-68 [24899153] J Clin Microbiol. 2016 Jan;54(1):142-7 [26560532] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0144911 ER - TY - JOUR T1 - Modern analytics for naturally derived complex drug substances: NMR and MS tests for protamine sulfate from chum salmon AN - 1746896690; PQ0001516044 AB - This work describes orthogonal NMR and MS tests for the structure and composition of the drug protamine sulfate derived from chum salmon. The spectral response pattern obtained by 1D-[sup 1]H-NMR and MS methods from salmon protamine, a mixture of four predominant peptide chaths, is dependent on the amino acid sequence and abundance of each peptide. Thus, an assay was developed based on the ratios of alanine, glycine and arginine amino acid residue NMR peaks in this mixture that are unique to the salmon source. The specificity of the combined NMR and MS assay was tested by comparison to data obtained from herring protamine which contains a different mixture of peptides with related amino acid sequences. Both assays were able to clearly distinguish protamine derived from these different natural sources. JF - Analytical and Bioanalytical Chemistry AU - Gucinski, Ashley C AU - Boyne, Michael T, II AU - Keire, David A AD - Division of Pharmaceutical Research, Office of Testing and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 645 S. Newstead Ave., St. Louis, MO 63110, USA, david.keire@fda.hhs.gov PY - 2015 SP - 749 EP - 759 PB - Springer Science+Business Media VL - 407 IS - 3 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - NMR KW - LC-MS KW - Peptide drug quality KW - Salmon KW - Testing Procedures KW - Sulfates KW - Amino Acids KW - Fish (herring family) KW - Assay KW - Peptides KW - Drugs KW - AQ 00001:Water Resources and Supplies KW - SW 5010:Network design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746896690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Modern+analytics+for+naturally+derived+complex+drug+substances%3A+NMR+and+MS+tests+for+protamine+sulfate+from+chum+salmon&rft.au=Gucinski%2C+Ashley+C%3BBoyne%2C+Michael+T%2C+II%3BKeire%2C+David+A&rft.aulast=Gucinski&rft.aufirst=Ashley&rft.date=2015-01-01&rft.volume=407&rft.issue=3&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-014-8172-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 26 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Sulfates; Testing Procedures; Salmon; Amino Acids; Fish (herring family); Assay; Peptides; Drugs DO - http://dx.doi.org/10.1007/s00216-014-8172-2 ER - TY - JOUR T1 - Filament Dynamics during Simulated Ventricular Fibrillation in a High-Resolution Rabbit Heart AN - 1746894458; PQ0002314741 AB - The mechanisms underlying ventricular fibrillation (VF) are not well understood. The electrical activity on the heart surface during VF has been recorded extensively in the experimental setting and in some cases clinically; however, corresponding transmural activation patterns are prohibitively difficult to measure. In this paper, we use a high-resolution biventricular heart model to study three-dimensional electrical activity during fibrillation, focusing on the driving sources of VF: "filaments," the organising centres of unstable reentrant scroll waves. We show, for the first time, specific 3D filament dynamics during simulated VF in a whole heart geometry that includes fine-scale anatomical structures. Our results suggest that transmural activity is much more complex than what would be expected from surface observations alone. We present examples of complex intramural activity, including filament breakup and reattachment, anchoring to the thin right ventricular apex; rapid transitions among various filament shapes; and filament lengths much greater than wall thickness. We also present evidence for anatomy playing a major role in VF development and coronary vessels and trabeculae influencing filament dynamics. Overall, our results indicate that intramural activity during simulated VF is extraordinarily complex and suggest that further investigation of 3D filaments is necessary to fully comprehend recorded surface patterns. JF - BioMed Research International AU - Pathmanathan, Pras AU - Gray, Richard A AD - U.S. Food and Drug Administration, 10903 New Hampshire Avenue (WO 62), Silver Spring, MD 20993, USA, pras.pathmanathan@fda.hhs.gov Y1 - 2015/01// PY - 2015 DA - January 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Ventricle KW - Fibrillation KW - Animal models KW - Waves KW - Filaments KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746894458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Filament+Dynamics+during+Simulated+Ventricular+Fibrillation+in+a+High-Resolution+Rabbit+Heart&rft.au=Pathmanathan%2C+Pras%3BGray%2C+Richard+A&rft.aulast=Pathmanathan&rft.aufirst=Pras&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F720575 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 1 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Heart; Ventricle; Fibrillation; Animal models; Waves; Filaments; Models DO - http://dx.doi.org/10.1155/2015/720575 ER - TY - JOUR T1 - Quantitation of viable Coxiella burnetii in milk using an integrated cell culture-polymerase chain reaction (ICC-PCR) assay AN - 1746885187; PQ0002258347 AB - The obligate intracellular pathogen Coxiella burnetii has long been considered the most heat resistant pathogen in raw milk, making it the reference pathogen for determining pasteurisation conditions for milk products. New milk formulations and novel non-thermal processes require validation of effectiveness which requires a more practical method for analysis than using the currently used animal model for assessing Coxiella survival. Also, there is an interest in better characterising thermal inactivation of Coxiella in various milk formulations. To avoid the use of the guinea pig model for evaluating Coxiella survival, an Integrated Cell Culture-PCR (ICC-PCR) method was developed for determining Coxiella viability in milk. Vero cell cultures were directly infected from Coxiella-contaminated milk in duplicate 24-well plates. Viability of the Coxiella in milk was shown by a greater than or equal to 0.5 log genome equivalent (ge)/ml increase in the quantity of IS111a gene from the baseline post-infection (day 0) level after 9-11 d propagation. Coxiella in skim, 2%, and whole milk, and half and half successfully infected Vero cells and increased in number by at least 2 logs using a 48-h infection period followed by 9-d propagation time. As few as 125 Coxiella ge/ml in whole milk was shown to infect and propagate at least 2 logs in the optimised ICC-PCR assay, though variable confirmation of propagation was shown for as low as 25 Coxiella ge/ml. Applicability of the ICC-PCR method was further proven in an MPN format to quantitate the number of viable Coxiella remaining in whole milk after 60 degree C thermal treatment at 0, 20, 40, 60 and 90 min. JF - Journal of Dairy Research AU - Stewart, Diana AU - Shieh, Y-Carol AU - Tortorello, Mary AU - Kukreja, Ankush AU - Shazer, Arlette AU - Schlesser, Joseph AD - US Food and Drug Administration, Division of Food Processing Science & Technology, Bedford Park, IL 60501, USA, diana.stewart@fda.hhs.gov PY - 2015 SP - 478 EP - 484 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 82 IS - 4 SN - 0022-0299, 0022-0299 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Genomes KW - Vero cells KW - Animal models KW - Cell culture KW - Pathogens KW - Infection KW - Pasteurization KW - Coxiella burnetii KW - Milk products KW - Heat KW - Quantitation KW - X 24320:Food Additives & Contaminants KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746885187?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Dairy+Research&rft.atitle=Quantitation+of+viable+Coxiella+burnetii+in+milk+using+an+integrated+cell+culture-polymerase+chain+reaction+%28ICC-PCR%29+assay&rft.au=Stewart%2C+Diana%3BShieh%2C+Y-Carol%3BTortorello%2C+Mary%3BKukreja%2C+Ankush%3BShazer%2C+Arlette%3BSchlesser%2C+Joseph&rft.aulast=Stewart&rft.aufirst=Diana&rft.date=2015-01-01&rft.volume=82&rft.issue=4&rft.spage=478&rft.isbn=&rft.btitle=&rft.title=Journal+of+Dairy+Research&rft.issn=00220299&rft_id=info:doi/10.1017%2FS0022029915000400 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 20 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Genomes; Cell survival; Milk products; Vero cells; Heat; Animal models; Cell culture; Pathogens; Infection; Quantitation; Pasteurization; Coxiella burnetii DO - http://dx.doi.org/10.1017/S0022029915000400 ER - TY - JOUR T1 - Maternal occupational pesticide exposure and risk of congenital heart defects in the national birth defects prevention study AN - 1746882231; PQ0002167305 AB - BACKGROUND Congenital heart defects (CHDs) are common birth defects, affecting approximately 1% of live births. Pesticide exposure has been suggested as an etiologic factor for CHDs, but previous results were inconsistent. METHODS We examined maternal occupational exposure to fungicides, insecticides, and herbicides for 3328 infants with CHDs and 2988 unaffected control infants of employed mothers using data for 1997 through 2002 births from the National Birth Defects Prevention Study, a population-based multisite case-control study. Potential pesticide exposure from 1 month before conception through the first trimester of pregnancy was assigned by an expert-guided task-exposure matrix and job history details self-reported by mothers. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression. RESULTS Maternal occupational exposure to pesticides was not associated with CHDs overall. In examining specific CHD subtypes compared with controls, some novel associations were observed with higher estimated pesticide exposure: insecticides only and secundum atrial septal defect (OR=1.8; 95% CI, 1.3-2.7, 40 exposed cases); both insecticides and herbicides and hypoplastic left heart syndrome (OR=5.1; 95% CI, 1.7-15.3, 4 exposed cases), as well as pulmonary valve stenosis (OR=3.6; 95% CI, 1.3-10.1, 5 exposed cases); and insecticides, herbicides, and fungicides and tetralogy of Fallot (TOF) (OR=2.2; 95% CI, 1.2-4.0, 13 exposed cases). CONCLUSION Broad pesticide exposure categories were not associated with CHDs overall, but examining specific CHD subtypes revealed some increased odds ratios. These results highlight the importance of examining specific CHDs separately. Because of multiple comparisons, additional work is needed to verify these associations. Birth Defects Research (Part A) 103:823-833, 2015. JF - Birth Defects Research Part A: Clinical and Molecular Teratology AU - Rocheleau, Carissa M AU - Bertke, Stephen J AU - Lawson, Christina C AU - Romitti, Paul A AU - Sanderson, Wayne T AU - Malik, Sadia AU - Lupo, Philip J AU - Desrosiers, Tania A AU - Bell, Erin AU - Druschel, Charlotte AU - Correa, Adolfo AU - Reefhuis, Jennita AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio. PY - 2015 SP - 823 EP - 833 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 103 IS - 10 SN - 1542-0752, 1542-0752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Historical account KW - Prevention KW - Insecticides KW - Risk factors KW - Pesticides KW - Fungicides KW - Congenital defects KW - Herbicides KW - Occupational exposure KW - Infants KW - Pregnancy KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746882231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.atitle=Maternal+occupational+pesticide+exposure+and+risk+of+congenital+heart+defects+in+the+national+birth+defects+prevention+study&rft.au=Rocheleau%2C+Carissa+M%3BBertke%2C+Stephen+J%3BLawson%2C+Christina+C%3BRomitti%2C+Paul+A%3BSanderson%2C+Wayne+T%3BMalik%2C+Sadia%3BLupo%2C+Philip+J%3BDesrosiers%2C+Tania+A%3BBell%2C+Erin%3BDruschel%2C+Charlotte%3BCorrea%2C+Adolfo%3BReefhuis%2C+Jennita&rft.aulast=Rocheleau&rft.aufirst=Carissa&rft.date=2015-01-01&rft.volume=103&rft.issue=10&rft.spage=823&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.issn=15420752&rft_id=info:doi/10.1002%2Fbdra.23351 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Historical account; Prevention; Insecticides; Risk factors; Fungicides; Pesticides; Congenital defects; Herbicides; Occupational exposure; Pregnancy; Infants DO - http://dx.doi.org/10.1002/bdra.23351 ER - TY - JOUR T1 - Blood Pyrrole-Protein Adducts--A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans. AN - 1738818900; 26398275 AB - Pyrrolizidine alkaloids (PAs) induce liver injury (PA-ILI) and is very likely to contribute significantly to drug-induced liver injury (DILI). In this study we used a newly developed ultra-high performance liquid chromatography-triple quadrupole-mass spectrometry (UHPLC-MS)-based method to detect and quantitate blood pyrrole-protein adducts in DILI patients. Among the 46 suspected DILI patients, 15 were identified as PA-ILI by the identification of PA-containing herbs exposed. Blood pyrrole-protein adducts were detected in all PA-ILI patients (100%). These results confirm that PA-ILI is one of the major causes of DILI and that blood pyrrole-protein adducts quantitated by the newly developed UHPLC-MS method can serve as a specific biomarker of PA-ILI. JF - Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews AU - Ruan, Jianqing AU - Gao, Hong AU - Li, Na AU - Xue, Junyi AU - Chen, Jie AU - Ke, Changqiang AU - Ye, Yang AU - Fu, Peter Pi-Cheng AU - Zheng, Jiang AU - Wang, Jiyao AU - Lin, Ge AD - a School of Biomedical Sciences, Faculty of Medicine , The Chinese University of Hong Kong , Hong Kong SAR , Hong Kong. ; b Division of Gastroenterology, Zhongshan Hospital , Fudan University , Shanghai , P. R. China. ; c Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica , Chinese Academy of Sciences and The Chinese University of Hong Kong , Hong Kong SAR , Hong Kong. ; e National Center for Toxicological Research , Jefferson , Arkansas , USA. ; f Center for Developmental Therapeutics, Seattle Children's Research Institute, Division of Gastroenterology, Department of Pediatrics , University of Washington , Washington , USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 404 EP - 421 VL - 33 IS - 4 KW - Biomarkers KW - 0 KW - Pyrroles KW - Pyrrolizidine Alkaloids KW - Toxins, Biological KW - Index Medicus KW - pyrrolizidine alkaloids KW - hepatic sinusoidal obstruction syndrome KW - pyrrole-protein adducts KW - hepatotoxicity KW - Animals KW - Humans KW - Aged KW - Chromatography, High Pressure Liquid KW - Toxins, Biological -- metabolism KW - Rats KW - Toxins, Biological -- chemistry KW - Adult KW - Toxicity Tests KW - Middle Aged KW - Adolescent KW - Female KW - Male KW - Pyrrolizidine Alkaloids -- blood KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Pyrroles -- blood KW - Pyrroles -- chemistry KW - Pyrrolizidine Alkaloids -- metabolism KW - Hepatic Veno-Occlusive Disease -- blood KW - Biomarkers -- blood KW - Pyrrolizidine Alkaloids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738818900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.atitle=Blood+Pyrrole-Protein+Adducts--A+Biomarker+of+Pyrrolizidine+Alkaloid-Induced+Liver+Injury+in+Humans.&rft.au=Ruan%2C+Jianqing%3BGao%2C+Hong%3BLi%2C+Na%3BXue%2C+Junyi%3BChen%2C+Jie%3BKe%2C+Changqiang%3BYe%2C+Yang%3BFu%2C+Peter+Pi-Cheng%3BZheng%2C+Jiang%3BWang%2C+Jiyao%3BLin%2C+Ge&rft.aulast=Ruan&rft.aufirst=Jianqing&rft.date=2015-01-01&rft.volume=33&rft.issue=4&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+science+and+health.+Part+C%2C+Environmental+carcinogenesis+%26+ecotoxicology+reviews&rft.issn=1532-4095&rft_id=info:doi/10.1080%2F10590501.2015.1096882 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-09 N1 - Date created - 2015-12-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/10590501.2015.1096882 ER - TY - JOUR T1 - Considerations for Using Genetic and Epigenetic Information in Occupational Health Risk Assessment and Standard Setting. AN - 1736415058; 26583908 AB - Risk assessment forms the basis for both occupational health decision-making and the development of occupational exposure limits (OELs). Although genetic and epigenetic data have not been widely used in risk assessment and ultimately, standard setting, it is possible to envision such uses. A growing body of literature demonstrates that genetic and epigenetic factors condition biological responses to occupational and environmental hazards or serve as targets of them. This presentation addresses the considerations for using genetic and epigenetic information in risk assessments, provides guidance on using this information within the classic risk assessment paradigm, and describes a framework to organize thinking about such uses. The framework is a 4 × 4 matrix involving the risk assessment functions (hazard identification, dose-response modeling, exposure assessment, and risk characterization) on one axis and inherited and acquired genetic and epigenetic data on the other axis. The cells in the matrix identify how genetic and epigenetic data can be used for each risk assessment function. Generally, genetic and epigenetic data might be used as endpoints in hazard identification, as indicators of exposure, as effect modifiers in exposure assessment and dose-response modeling, as descriptors of mode of action, and to characterize toxicity pathways. Vast amounts of genetic and epigenetic data may be generated by high-throughput technologies. These data can be useful for assessing variability and reducing uncertainty in extrapolations, and they may serve as the foundation upon which identification of biological perturbations would lead to a new paradigm of toxicity pathway-based risk assessments. JF - Journal of occupational and environmental hygiene AU - Schulte, P A AU - Whittaker, C AU - Curran, C P AD - a Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH), Education and Information Division , Cincinnati , Ohio. ; b Northern Kentucky University, Department of Biological Sciences , Highland Heights , Kentucky. Y1 - 2015 PY - 2015 DA - 2015 SP - S69 EP - S81 VL - 12 Suppl 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - polymorphisms KW - genotype KW - gene-environment interaction KW - xenobiotic, molecular epidemiology KW - Genetics KW - Polymorphism, Genetic KW - Humans KW - Gene-Environment Interaction KW - Toxicogenetics -- methods KW - Risk Assessment KW - Occupational Exposure -- standards KW - Epigenesis, Genetic KW - Occupational Health -- standards KW - Occupational Exposure -- analysis KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736415058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Considerations+for+Using+Genetic+and+Epigenetic+Information+in+Occupational+Health+Risk+Assessment+and+Standard+Setting.&rft.au=Schulte%2C+P+A%3BWhittaker%2C+C%3BCurran%2C+C+P&rft.aulast=Schulte&rft.aufirst=P&rft.date=2015-01-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=S69&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1060323 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-23 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cancer Res. 2004 Mar 15;64(6):2258-63 [15026371] Cytogenet Genome Res. 2004;104(1-4):376-82 [15162068] Toxicol Pathol. 2004 Jul-Aug;32(4):482-92 [15223774] Int J Epidemiol. 2004 Oct;33(5):929-35 [15166187] Mutat Res. 1979 Feb;59(2):245-56 [440322] Risk Anal. 1995 Apr;15(2):205-13 [7597257] Environ Health Perspect. 1998 Jul;106(7):365-8 [9637792] Toxicol Appl Pharmacol. 1999 Aug 1;158(3):221-30 [10438655] Nat Rev Genet. 2005 Apr;6(4):287-98 [15803198] J Gerontol B Psychol Sci Soc Sci. 2005 Mar;60 Spec No 1:53-64 [15863710] Pharmacogenet Genomics. 2005 Jul;15(7):503-11 [15970798] Environ Health Perspect. 2005 Jul;113(7):840-8 [16002370] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50 [16103423] Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):34-42 [15982695] Nat Biotechnol. 2006 Jan;24(1):55-62 [16404398] Environ Health Perspect. 2012 Oct;120(10):1353-61 [22672778] Cold Spring Harb Perspect Biol. 2012 Dec;4(12). pii: a012773. doi: 10.1101/cshperspect.a012773 [23209155] Arch Toxicol. 2013 Jan;87(1):13-4 [23149676] Environ Health Perspect. 2013 Jan;121(1):23-31 [23086705] ALTEX. 2013;30(1):51-6 [23338806] Pac Symp Biocomput. 2013;:373-84 [23424142] Environ Health Perspect. 2013 Apr;121(4):405-9 [23380895] Hum Genet. 2013 May;132(5):495-508 [23334806] Mutagenesis. 2007 Mar;22(2):91-103 [17284773] Environ Health Perspect. 2007 Feb;115(2):231-4 [17384770] Reprod Toxicol. 2007 Apr-May;23(3):267-82 [17317097] Environ Health Perspect. 2007 May;115(5):833-40 [17520075] Lancet. 2007 Oct 20;370(9596):1453-7 [18064739] Int J Epidemiol. 2008 Feb;37(1):120-32 [17898028] JAMA. 2008 Mar 19;299(11):1345-50 [18349095] Mar Pollut Bull. 2008 Apr;56(4):613-9 [18313083] Int J Environ Res Public Health. 2008 Mar;5(1):4-11 [18441400] Occup Environ Med. 2008 Jun;65(6):430-6; 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AN - 1736414992; 26132979 AB - In a recent National Research Council document, new strategies for risk assessment were described to enable more accurate and quicker assessments. This report suggested that evaluating individual responses through increased use of bio-monitoring could improve dose-response estimations. Identification of specific biomarkers may be useful for diagnostics or risk prediction as they have the potential to improve exposure assessments. This paper discusses systems biology, biomarkers of effect, and computational toxicology approaches and their relevance to the occupational exposure limit setting process. The systems biology approach evaluates the integration of biological processes and how disruption of these processes by chemicals or other hazards affects disease outcomes. This type of approach could provide information used in delineating the mode of action of the response or toxicity, and may be useful to define the low adverse and no adverse effect levels. Biomarkers of effect are changes measured in biological systems and are considered to be preclinical in nature. Advances in computational methods and experimental -omics methods that allow the simultaneous measurement of families of macromolecules such as DNA, RNA, and proteins in a single analysis have made these systems approaches feasible for broad application. The utility of the information for risk assessments from -omics approaches has shown promise and can provide information on mode of action and dose-response relationships. As these techniques evolve, estimation of internal dose and response biomarkers will be a critical test of these new technologies for application in risk assessment strategies. While proof of concept studies have been conducted that provide evidence of their value, challenges with standardization and harmonization still need to be overcome before these methods are used routinely. JF - Journal of occupational and environmental hygiene AU - DeBord, D Gayle AU - Burgoon, Lyle AU - Edwards, Stephen W AU - Haber, Lynne T AU - Kanitz, M Helen AU - Kuempel, Eileen AU - Thomas, Russell S AU - Yucesoy, Berran AD - a National Institute for Occupational Safety and Health, Division of Applied Research and Technology , Cincinnati , Ohio. ; b U.S. Environmental Protection Agency, Office of Research and Development, Research Triangle Park , North Carolina. ; c Toxicology Excellence for Risk Assessment (TERA) , Cincinnati , Ohio. ; d National Institute for Occupational Safety and Health, Education and Information Division , Cincinnati , Ohio. ; f National Institute for Occupational Safety and Health, Heath Effects Laboratory Division , Morgantown , West Virginia. Y1 - 2015 PY - 2015 DA - 2015 SP - S41 EP - S54 VL - 12 Suppl 1 KW - Biomarkers KW - 0 KW - Index Medicus KW - occupational KW - exposure assessment KW - risk assessment KW - dose-response KW - biomarkers KW - Environmental Monitoring KW - Dose-Response Relationship, Drug KW - Humans KW - Systems Biology KW - Risk Assessment KW - Occupational Exposure -- standards KW - Biomarkers -- analysis KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736414992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Systems+Biology+and+Biomarkers+of+Early+Effects+for+Occupational+Exposure+Limit+Setting.&rft.au=DeBord%2C+D+Gayle%3BBurgoon%2C+Lyle%3BEdwards%2C+Stephen+W%3BHaber%2C+Lynne+T%3BKanitz%2C+M+Helen%3BKuempel%2C+Eileen%3BThomas%2C+Russell+S%3BYucesoy%2C+Berran&rft.aulast=DeBord&rft.aufirst=D&rft.date=2015-01-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=S41&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1060324 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-23 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2000 Jul;162(1):295-300 [10903257] Annu Rev Pharmacol Toxicol. 2001;41:347-66 [11264461] Toxicol Sci. 2001 May;61(1):18-31 [11294970] Genet Res. 2001 Apr;77(2):123-8 [11355567] Mutat Res. 2001 Oct 1;482(1-2):71-6 [11535250] Mutat Res. 2002 Jan 29;499(1):13-25 [11804602] Environ Health Perspect. 2012 Nov;120(11):1499-502 [22875311] Tohoku J Exp Med. 2013;229(3):173-85 [23419314] Toxicology. 2002 Dec 27;181-182:275-9 [12505325] Nat Genet. 2003 Feb;33(2):177-82 [12524541] Crit Rev Toxicol. 2003;33(5):505-42 [14594105] J Toxicol Environ Health A. 2004 Apr 23-May 28;67(8-10):687-95 [15192862] Cancer Res. 1976 Sep;36(9 pt.1):2973-9 [975067] Fundam Appl Toxicol. 1984 Oct;4(5):854-71 [6510615] Environ Health Perspect. 1987 Oct;74:3-9 [3691432] Epidemiol Prev. 1992 Dec;14(53):32-9 [1341666] Risk Anal. 1994 Aug;14(4):421-31 [7972952] Carcinogenesis. 1997 Feb;18(2):423-30 [9054638] Am J Epidemiol. 1998 Nov 15;148(10):929-36 [9829864] Nat Genet. 1999 Jan;21(1 Suppl):33-7 [9915498] Trends Biotechnol. 2005 Mar;23(3):122-7 [15734554] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50 [16103423] Nat Biotechnol. 2006 Sep;24(9):1103 [16964221] Toxicol Sci. 2007 Jan;95(1):5-12 [16963515] Environ Health Perspect. 2007 Feb;115(2):231-4 [17384770] Environ Health Perspect. 2007 Mar;115(3):410-5 [17431491] Pharmacogenomics. 2007 May;8(5):425-30 [17465705] Toxicol Sci. 2007 Jul;98(1):240-8 [17449896] Inhal Toxicol. 2007;19 Suppl 1:189-98 [17886067] Annu Rev Pharmacol Toxicol. 2008;48:653-83 [18184107] BMC Genomics. 2007;8:387 [17961223] Inhal Toxicol. 2008 Jan;20(1):53-62 [18236223] Crit Rev Toxicol. 2008;38(2):87-96 [18259981] Toxicology. 2008 Mar 20;245(3):167-74 [18237837] Toxicol Sci. 2008 May;103(1):14-27 [18065772] Regul Toxicol Pharmacol. 2008 Aug;51(3 Suppl):S4-15 [18583008] Toxicol Lett. 2008 Aug 15;180(2):85-92 [18588961] Drugs R D. 2008;9(5):307-22 [18721000] Nat Rev Genet. 2008 Nov;9(11):819-30 [18852695] Toxicol Sci. 2008 Dec;106(2):312-8 [18791183] Regul Toxicol Pharmacol. 2008 Dec;52(3):264-89 [18775759] Toxicol Sci. 2009 Feb;107(2):324-30 [19074763] Environ Health Perspect. 2009 Feb;117(2):283-7 [19270800] Nature. 2009 Sep 10;461(7261):218-23 [19741703] Nucleic Acids Res. 2010 Jan;38(Database issue):D355-60 [19880382] Environ Health Perspect. 2010 Feb;118(2):259-64 [20123609] J Toxicol Environ Health A. 2010;73(5):445-61 [20155585] Environ Health Perspect. 2010 May;118(5):585-8 [20056564] Clin Pharmacol Ther. 2010 Jul;88(1):25-33 [20531468] J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):253-76 [20574901] Ann N Y Acad Sci. 1999;895:286-316 [10676424] J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):291-8 [20574903] J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):314-28 [20574905] Risk Anal. 2010 Jul;30(7):1037-51 [20412521] Environ Health Perspect. 2010 Aug;118(8):1047-50 [20483702] Toxicol Lett. 2010 Sep 15;198(1):44-8 [20447450] Toxicol Sci. 2010 Nov;118(1):224-35 [20705892] Toxicol Sci. 2013 Jul;134(1):180-94 [23596260] Epilepsia. 2013 Dec;54 Suppl 9:35-9 [24328870] Nature. 2002 Nov 14;420(6912):206-10 [12432404] Ann Occup Hyg. 2002 Mar;46(2):175-85 [12074027] Regul Toxicol Pharmacol. 2002 Jun;35(3):448-67 [12202058] Mutat Res. 2010 Dec;705(3):172-83 [20382258] Environ Health Perspect. 2010 Dec;118(12):1714-20 [20826373] Crit Rev Toxicol. 2011 Jan;41(1):1-19 [21226629] Regul Toxicol Pharmacol. 2011 Feb;59(1):125-32 [20933039] Expert Opin Drug Metab Toxicol. 2011 Mar;7(3):287-98 [21254873] Toxicol Sci. 2011 Mar;120(1):194-205 [21097997] Chem Res Toxicol. 2011 Apr 18;24(4):451-62 [21384849] Int J Hyg Environ Health. 2011 Jun;214(3):179-87 [21440498] Toxicol Appl Pharmacol. 2011 Jul 15;254(2):192-7 [21034766] Environ Health Perspect. 2011 Nov;119(11):1539-46 [21788197] Environ Health Perspect. 2012 Jan;120(1):A13; author reply A13 [22214547] Toxicol Sci. 2012 May;127(1):199-215 [22298810] Toxicol Sci. 2012 Aug;128(2):398-417 [22543276] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1060324 ER - TY - JOUR T1 - The Global Landscape of Occupational Exposure Limits--Implementation of Harmonization Principles to Guide Limit Selection. AN - 1736414401; 26099071 AB - Occupational exposure limits (OELs) serve as health-based benchmarks against which measured or estimated workplace exposures can be compared. In the years since the introduction of OELs to public health practice, both developed and developing countries have established processes for deriving, setting, and using OELs to protect workers exposed to hazardous chemicals. These processes vary widely, however, and have thus resulted in a confusing international landscape for identifying and applying such limits in workplaces. The occupational hygienist will encounter significant overlap in coverage among organizations for many chemicals, while other important chemicals have OELs developed by few, if any, organizations. Where multiple organizations have published an OEL, the derived value often varies considerably-reflecting differences in both risk policy and risk assessment methodology as well as access to available pertinent data. This article explores the underlying reasons for variability in OELs, and recommends the harmonization of risk-based methods used by OEL-deriving organizations. A framework is also proposed for the identification and systematic evaluation of OEL resources, which occupational hygienists can use to support risk characterization and risk management decisions in situations where multiple potentially relevant OELs exist. JF - Journal of occupational and environmental hygiene AU - Deveau, M AU - Chen, C-P AU - Johanson, G AU - Krewski, D AU - Maier, A AU - Niven, K J AU - Ripple, S AU - Schulte, P A AU - Silk, J AU - Urbanus, J H AU - Zalk, D M AU - Niemeier, R W AD - a McLaughlin Centre for Population Health Risk Assessment, University of Ottawa , Ottawa , Ontario , Canada. ; c Department of Occupational Safety and Health, College of Public Health, China Medical University , Taichung , Taiwan. ; d Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet , Stockholm , Sweden. ; e Department of Environmental Health, College of Medicine, University of Cincinnati , Cincinnati , Ohio. ; f Shell Health, Shell International B.V. , The Hague , The Netherlands. ; g Global Industrial Hygiene Expertise Center, The Dow Chemical Company , Midland , Michigan. ; h Education and Information Division, National Institute for Occupational Safety and Health , Cincinnati , Ohio. ; i Directorate of Standards and Guidance, Occupational Safety and Health Administration , Washington, DC (Retired). ; j ES&H Directorate, Lawrence Livermore National Laboratory , Livermore , California. ; k Education and Information Division, National Institute for Occupational Safety and Health , Cincinnati , Ohio. Y1 - 2015 PY - 2015 DA - 2015 SP - S127 EP - S144 VL - 12 Suppl 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - harmonization KW - risk policy KW - risk science KW - occupational exposure limit KW - Occupational Health KW - International Cooperation KW - Humans KW - Risk Management KW - Hazardous Substances -- toxicity KW - Threshold Limit Values KW - Occupational Exposure -- prevention & control KW - Occupational Exposure -- standards KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736414401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+Global+Landscape+of+Occupational+Exposure+Limits--Implementation+of+Harmonization+Principles+to+Guide+Limit+Selection.&rft.au=Deveau%2C+M%3BChen%2C+C-P%3BJohanson%2C+G%3BKrewski%2C+D%3BMaier%2C+A%3BNiven%2C+K+J%3BRipple%2C+S%3BSchulte%2C+P+A%3BSilk%2C+J%3BUrbanus%2C+J+H%3BZalk%2C+D+M%3BNiemeier%2C+R+W&rft.aulast=Deveau&rft.aufirst=M&rft.date=2015-01-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=S127&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1060327 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-23 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Toxicol Environ Health B Crit Rev. 2010 Oct;13(7-8):546-78 [21170809] Regul Toxicol Pharmacol. 2010 Nov;58(2):323-9 [20655351] J Toxicol Environ Health A. 2011;74(2-4):261-85 [21218351] Crit Rev Toxicol. 2010 Oct;40(9):791-8 [20860525] Crit Rev Toxicol. 2010 Sep;40(8):671-96 [20722583] Int J Occup Environ Health. 2010 Jul-Sep;16(3):249-62 [20662417] Ind Health. 2010;48(1):18-28 [20160404] Toxicol Appl Pharmacol. 2008 Nov 15;233(1):71-5 [19013305] J Appl Toxicol. 2008 Oct;28(7):858-66 [18381691] Regul Toxicol Pharmacol. 2008 Aug;51(3):253-69 [18502550] J Occup Environ Hyg. 2008 May;5(5):330-46 [18350442] Regul Toxicol Pharmacol. 2008 Mar;50(2):261-70 [18226844] J Occup Environ Hyg. 2015;12 Suppl 1:S55-68 [26097979] J Occup Environ Hyg. 2015;12 Suppl 1:S7-17 [26252067] J Occup Environ Hyg. 2015;12 Suppl 1:S99-111 [26302336] Regul Toxicol Pharmacol. 2001 Oct;34(2):153-69 [11603958] Environ Health Perspect. 2014 Aug;122(8):796-805 [24727499] Toxicology. 2013 Nov 16;313(2-3):160-73 [23219588] Regul Toxicol Pharmacol. 2013 Jul;66(2):241-7 [23579077] Ann Occup Hyg. 2012 Jul;56(5):506-14 [22752095] Ann Occup Hyg. 2012 Jul;56(5):525-41 [22267129] Regul Toxicol Pharmacol. 2011 Dec;61(3):296-309 [21907258] Regul Toxicol Pharmacol. 2011 Oct;61(1):63-72 [21712060] Toxicol Sci. 2011 Jun;121(2):408-16 [21389111] Regul Toxicol Pharmacol. 2002 Dec;36(3):262-79 [12473411] Regul Toxicol Pharmacol. 1983 Sep;3(3):224-38 [6356243] Am J Ind Med. 1988;13(5):531-59 [3287906] Regul Toxicol Pharmacol. 1991 Jun;13(3):241-62 [1682974] Ann Occup Hyg. 1991 Dec;35(6):569-80 [1768007] Toxicol Lett. 1992 Dec;64-65 Spec No:53-7 [1471206] Toxicol Lett. 1995 May;77(1-3):183-7 [7618133] Regul Toxicol Pharmacol. 1997 Feb;25(1):1-5 [9056496] Regul Toxicol Pharmacol. 1997 Apr;25(2):121-9 [9185888] Toxicol Sci. 2005 Aug;86(2):226-30 [15829616] Regul Toxicol Pharmacol. 2005 Oct;43(1):1-9 [16099564] J Toxicol Environ Health B Crit Rev. 2007 Oct;10(7):527-57 [17934949] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1060327 ER - TY - JOUR T1 - Aggregate Exposure and Cumulative Risk Assessment--Integrating Occupational and Non-occupational Risk Factors. AN - 1736414378; 26583907 AB - Occupational exposure limits have traditionally focused on preventing morbidity and mortality arising from inhalation exposures to individual chemical stressors in the workplace. While central to occupational risk assessment, occupational exposure limits have limited application as a refined disease prevention tool because they do not account for all of the complexities of the work and non-occupational environments and are based on varying health endpoints. To be of greater utility, occupational exposure limits and other risk management tools could integrate broader consideration of risks from multiple exposure pathways and routes (aggregate risk) as well as the combined risk from exposure to both chemical and non-chemical stressors, within and beyond the workplace, including the possibility that such exposures may cause interactions or modify the toxic effects observed (cumulative risk). Although still at a rudimentary stage in many cases, a variety of methods and tools have been developed or are being used in allied risk assessment fields to incorporate such considerations in the risk assessment process. These approaches, which are collectively referred to as cumulative risk assessment, have potential to be adapted or modified for occupational scenarios and provide a tangible path forward for occupational risk assessment. Accounting for complex exposures in the workplace and the broader risks faced by the individual also requires a more complete consideration of the composite effects of occupational and non-occupational risk factors to fully assess and manage worker health problems. Barriers to integrating these different factors remain, but new and ongoing community-based and worker health-related initiatives may provide mechanisms for identifying and integrating risk from aggregate exposures and cumulative risks from all relevant sources, be they occupational or non-occupational. JF - Journal of occupational and environmental hygiene AU - Lentz, T J AU - Dotson, G S AU - Williams, P R D AU - Maier, A AU - Gadagbui, B AU - Pandalai, S P AU - Lamba, A AU - Hearl, F AU - Mumtaz, M AD - a Education and Information Division, Centers for Disease Control and Prevention , National Institute for Occupational Safety and Health , Cincinnati , Ohio. ; b E Risk Sciences , LLP , Boulder , Colorado. ; c Department of Environmental Health , University of Cincinnati College of Medicine , Cincinnati , Ohio. ; d Toxicology Excellence for Risk Assessment , Cincinnati , Ohio. ; e Office of Pollution Prevention and Toxics , Environmental Protection Agency , Washington , DC. ; f Office of the Director, Centers for Disease Control and Prevention , National Institute for Occupational Safety and Health , Washington , DC. ; g Agency for Toxic Substances and Disease Registry , Centers for Disease Control and Prevention , Atlanta , Georgia. Y1 - 2015 PY - 2015 DA - 2015 SP - S112 EP - S126 VL - 12 Suppl 1 KW - Index Medicus KW - occupational KW - cumulative risk KW - aggregate exposure KW - Risk Factors KW - Humans KW - Occupational Diseases -- etiology KW - Toxicology -- methods KW - Environmental Exposure -- adverse effects KW - Stress, Physiological KW - Risk Assessment -- ethics KW - Occupational Exposure -- standards KW - Occupational Exposure -- adverse effects KW - Health Behavior KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1736414378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Aggregate+Exposure+and+Cumulative+Risk+Assessment--Integrating+Occupational+and+Non-occupational+Risk+Factors.&rft.au=Lentz%2C+T+J%3BDotson%2C+G+S%3BWilliams%2C+P+R+D%3BMaier%2C+A%3BGadagbui%2C+B%3BPandalai%2C+S+P%3BLamba%2C+A%3BHearl%2C+F%3BMumtaz%2C+M&rft.aulast=Lentz&rft.aufirst=T&rft.date=2015-01-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=S112&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1060326 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-23 N1 - Date created - 2015-11-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Safety Res. 2004;35(3):255-61 [15288559] Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1 Suppl):51S-54S [21329566] Environ Res. 1992 Oct;59(1):67-80 [1425520] J Occup Environ Med. 2005 Feb;47(2):115-31 [15706171] J Occup Environ Hyg. 2005 Mar;2(3):127-35 [15764536] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50 [16103423] Toxicol Sci. 2005 Oct;87(2):520-8 [16002478] J Occup Environ Hyg. 2006 Oct;3(10):D102-9 [16998981] Environ Health Perspect. 2007 Mar;115(3):451-4 [17431498] Environ Health Perspect. 2007 May;115(5):825-32 [17520074] Dermatol Ther. 2008 Jan-Feb;21(1):54-9 [18318886] Regul Toxicol Pharmacol. 2008 Aug;51(3):253-69 [18502550] Ann Occup Hyg. 2008 Oct;52(7):555-66 [18765399] Cancer Causes Control. 2009 Aug;20(6):887-94 [19301135] J Am Acad Audiol. 2009 Oct;20(9):539-57 [19902702] ALTEX. 2011;28(3):175-82 [21993955] J Safety Res. 2012 Feb;43(1):67-74 [22385742] Am J Public Health. 2012 Mar;102(3):434-48 [22021293] Science. 2012 May 18;336(6083):907-11 [22605775] Workplace Health Saf. 2012 Oct;60(10):445-52 [23054164] Environ Sci Technol. 2012 Oct 16;46(20):10868-74 [22938698] Environ Health. 2013;12:31 [23587312] Scand J Work Environ Health. 2013 May 1;39(3):221-32 [23588858] Soc Sci Med. 2013 Sep;92:114-23 [23849285] Soc Sci Med. 2013 Sep;93:11-20 [23906116] Risk Anal. 2015 Jun;35(6):1040-9 [24724810] J Occup Environ Hyg. 2015;12 Suppl 1:S18-40 [26551218] J Occup Environ Hyg. 2015;12 Suppl 1:S41-54 [26132979] J Occup Environ Hyg. 2015;12 Suppl 1:S69-81 [26583908] Sci Total Environ. 2009 Dec 20;408(2):171-82 [19850321] J Fam Pract. 2010 Jan;59(1 Suppl):S3-S11 [20074508] J Expo Sci Environ Epidemiol. 2010 Jun;20(4):351-8 [19367326] J Agromedicine. 2010 Jul;15(3):200-15 [20665306] Environ Health Perspect. 2010 Aug;118(8):1081-90 [20308034] Scand J Work Environ Health. 2010 Sep;36(5):422-9 [20686738] J Expo Sci Environ Epidemiol. 2010 Sep;20(6):493-502 [20424649] Regul Toxicol Pharmacol. 1990 Apr;11(2):118-22 [2185507] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1060326 ER - TY - JOUR T1 - Evaluation of CYP3A4 inhibition and hepatotoxicity using DMSO-treated human hepatoma HuH-7 cells AN - 1735926868; PQ0002282656 AB - A human hepatoma cell line (HuH-7) was evaluated as a metabolically competent cell model to investigate cytochrome P450 3A4 (CYP3A4) inhibition, induction, and hepatotoxicity. First, CYP3A4 gene expression and activity were determined in HuH-7 cells under three culture conditions: 1-week culture, 3-week culture, or 1 % dimethyl sulfoxide (DMSO) treatment. HuH-7 cells treated with DMSO for 2 weeks after confluence expressed the highest CYP3A4 gene expression and activity compared to the other two culture conditions. Furthermore, CYP3A4 activity in DMSO-treated HuH-7 cells was compared to that in a human hepatoma cell line (HepG2/C3A) and human bipotent progenitor cell line (HepaRG), which yielded the following ranking: HepaRG > DMSO-treated HuH-7 >> HepG2/C3A cells. The effects of three known CYP3A4 inhibitors were evaluated using DMSO-treated HuH-7 cells. CYP3A4 enzyme inhibition in HuH-7 cells was further compared to human recombinant CYP3A4, indicating similar potency for reversible inhibitors (IC sub(50) within 2.5-fold), but different potency for the irreversible inhibitor. Next, induction of CYP3A4 activity was compared between DMSO-treated HuH-7 and HepaRG cells using two known inducers. DMSO-treated HuH-7 cells yielded minimal CYP3A4 induction compared to that in the HepaRG cells after 48-h treatments. Finally, the cytotoxicity of five known hepatotoxicants was evaluated in DMSO-treated HuH-7, HepG2/C3A, and HepaRG cells, and significant differences in cytotoxic sensitivity were observed. Overall, DMSO-treated HuH-7 cells are a valuable model for medium- or high-throughput screening of chemicals for CYP3A4 inhibition and hepatotoxicity. JF - Cell Biology and Toxicology AU - Liu, Yitong AU - Flynn, Thomas J AU - Xia, Menghang AU - Wiesenfeld, Paddy L AU - Ferguson, Martine S AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA, yitong.liu@fda.hhs.gov PY - 2015 SP - 221 EP - 230 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 31 IS - 4-5 SN - 0742-2091, 0742-2091 KW - Toxicology Abstracts KW - Hepatoma KW - CYP3A4 gene KW - Cytotoxicity KW - Stem cells KW - Dimethyl sulfoxide KW - Enzymes KW - Cell culture KW - high-throughput screening KW - Cytochrome P450 KW - hepatotoxicity KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735926868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Biology+and+Toxicology&rft.atitle=Evaluation+of+CYP3A4+inhibition+and+hepatotoxicity+using+DMSO-treated+human+hepatoma+HuH-7+cells&rft.au=Liu%2C+Yitong%3BFlynn%2C+Thomas+J%3BXia%2C+Menghang%3BWiesenfeld%2C+Paddy+L%3BFerguson%2C+Martine+S&rft.aulast=Liu&rft.aufirst=Yitong&rft.date=2015-01-01&rft.volume=31&rft.issue=4-5&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Cell+Biology+and+Toxicology&rft.issn=07422091&rft_id=info:doi/10.1007%2Fs10565-015-9306-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Number of references - 31 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - CYP3A4 gene; Hepatoma; Stem cells; Cytotoxicity; Dimethyl sulfoxide; Enzymes; high-throughput screening; Cell culture; Cytochrome P450; hepatotoxicity DO - http://dx.doi.org/10.1007/s10565-015-9306-9 ER - TY - JOUR T1 - Predictive biomarkers for treatment selection: statistical considerations. AN - 1734283235; 26507127 AB - Predictive biomarkers are developed for treatment selection to identify patients who are likely to benefit from a particular therapy. This review describes statistical methods and discusses issues in the development of predictive biomarkers to enhance study efficiency for detection of treatment effect on the selected responder patients in clinical studies. The statistical procedure for treatment selection consists of three components: biomarker identification, subgroup selection and clinical utility assessment. Major statistical issues discussed include biomarker designs, procedures to identify predictive biomarkers, classification models for subgroup selection, subgroup analysis and multiple testing for clinical utility assessment and evaluation. JF - Biomarkers in medicine AU - Chen, James J AU - Lu, Tzu-Pin AU - Chen, Yu-Chuan AU - Lin, Wei-Jiun AD - Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US Food & Drug Administration, Jefferson, AR 72079, USA. ; Department of Public Health, Institute of Epidemiology & Preventive Medicine, National Taiwan University, Taipei, Taiwan. ; Department of Applied Mathematics, Feng Chia University, Taichung, Taiwan. Y1 - 2015 PY - 2015 DA - 2015 SP - 1121 EP - 1135 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - Index Medicus KW - subgroup selection KW - predictive biomarker KW - personalized and precision medicine KW - subgroup analysis KW - predictive classifier KW - biomarker adaptive design KW - Humans KW - Safety KW - Therapeutics KW - Biomarkers -- analysis KW - Biostatistics -- methods KW - Decision Making UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734283235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Predictive+biomarkers+for+treatment+selection%3A+statistical+considerations.&rft.au=Chen%2C+James+J%3BLu%2C+Tzu-Pin%3BChen%2C+Yu-Chuan%3BLin%2C+Wei-Jiun&rft.aulast=Chen&rft.aufirst=James&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1121&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.84 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.84 ER - TY - JOUR T1 - microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment. AN - 1734282106; 26501795 AB - Much evidence has documented that microRNAs (miRNAs) play an important role in the modulation of interindividual variability in the production of drug metabolizing enzymes and transporters (DMETs) and nuclear receptors (NRs) through multidirectional interactions involving environmental stimuli/stressors, the expression of miRNA molecules and genetic polymorphisms. MiRNA expression has been reported to be affected by drugs and miRNAs themselves may affect drug metabolism and toxicity. In cancer research, miRNA biomarkers have been identified to mediate intrinsic and acquired resistance to cancer therapies. In drug safety assessment, miRNAs have been found associated with cardiotoxicity, hepatotoxicity and nephrotoxicity. This review article summarizes published studies to show that miRNAs can serve as early biomarkers for the evaluation of drug efficacy and drug safety. JF - Biomarkers in medicine AU - Koturbash, Igor AU - Tolleson, William H AU - Guo, Lei AU - Yu, Dianke AU - Chen, Si AU - Hong, Huixiao AU - Mattes, William AU - Ning, Baitang AD - Department of Environmental & Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. ; National Center for Toxicological Research, US Food & Drug Administration, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1153 EP - 1176 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - MicroRNAs KW - Index Medicus KW - nephrotoxicity KW - drug efficacy KW - biomarker KW - drug metabolizing enzymes KW - cardiotoxicity KW - microRNA KW - hepatotoxicity KW - drug safety KW - Animals KW - Humans KW - Drug Resistance, Neoplasm -- genetics KW - Biomarkers -- metabolism KW - MicroRNAs -- genetics KW - Safety KW - Pharmacogenetics -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734282106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=microRNAs+as+pharmacogenomic+biomarkers+for+drug+efficacy+and+drug+safety+assessment.&rft.au=Koturbash%2C+Igor%3BTolleson%2C+William+H%3BGuo%2C+Lei%3BYu%2C+Dianke%3BChen%2C+Si%3BHong%2C+Huixiao%3BMattes%2C+William%3BNing%2C+Baitang&rft.aulast=Koturbash&rft.aufirst=Igor&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1153&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.89 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.89 ER - TY - JOUR T1 - Biomarker-based drug safety assessment in the age of systems pharmacology: from foundational to regulatory science. AN - 1734282105; 26506997 AB - Improved biomarker-based assessment of drug safety is needed in drug discovery and development as well as regulatory evaluation. However, identifying drug safety-related biomarkers such as genes, proteins, miRNA and single-nucleotide polymorphisms remains a big challenge. The advances of 'omics' and computational technologies such as genomics, transcriptomics, metabolomics, proteomics, systems biology, network biology and systems pharmacology enable us to explore drug actions at the organ and organismal levels. Computational and experimental systems pharmacology approaches could be utilized to facilitate biomarker-based drug safety assessment for drug discovery and development and to inform better regulatory decisions. In this article, we review the current status and advances of systems pharmacology approaches for the development of predictive models to identify biomarkers for drug safety assessment. JF - Biomarkers in medicine AU - Zhang, Chen AU - Hong, Huixiao AU - Mendrick, Donna L AU - Tang, Yun AU - Cheng, Feixiong AD - Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China. ; National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1241 EP - 1252 VL - 9 IS - 11 KW - Biomarkers, Pharmacological KW - 0 KW - Pharmaceutical Preparations KW - Index Medicus KW - biomarker KW - systems biology KW - drug safety assessment KW - systems pharmacology KW - regulatory science KW - Animals KW - Humans KW - Biomarkers, Pharmacological -- metabolism KW - Systems Biology -- methods KW - Pharmacology -- methods KW - Social Control, Formal KW - Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734282105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Biomarker-based+drug+safety+assessment+in+the+age+of+systems+pharmacology%3A+from+foundational+to+regulatory+science.&rft.au=Zhang%2C+Chen%3BHong%2C+Huixiao%3BMendrick%2C+Donna+L%3BTang%2C+Yun%3BCheng%2C+Feixiong&rft.aulast=Zhang&rft.aufirst=Chen&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1241&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.81 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.81 ER - TY - JOUR T1 - Translating extracellular microRNA into clinical biomarkers for drug-induced toxicity: from high-throughput profiling to validation. AN - 1734282075; 26501984 AB - Over the past 5 years, extracellular microRNAs (miRNAs) are being vigorously explored as injury biomarkers, including drug-induced cardiotoxicity, hepatotoxicity and nephrotoxicity. Currently, the development of miRNAs as clinical biomarkers has been hindered by the lack of standardization. Therefore, extracellular miRNA-based biomarkers have not been embraced as diagnostic tools. Each platform has its strengths and weaknesses when working with low-input-amount RNA samples from body fluids; the selection of a miRNA quantification approach should be based on the study design. The following review provides a summary of the extracellular miRNA release and stability in body fluids, performances of different miRNA quantification platforms, existing clinical gold standards for drug-induced tissue damage and translation of the miRNA biomarkers from the nonclinical to clinical setting. JF - Biomarkers in medicine AU - Wang, Wenjun AU - Shi, Qiang AU - Mattes, Williams B AU - Mendrick, Donna L AU - Yang, Xi AD - College of Life Science, South-Central University for Nationalities, Wuhan 430074, PR China. ; Division of Systems Biology, National Center for Toxicological Research, Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1177 EP - 1188 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - MicroRNAs KW - Index Medicus KW - nephrotoxicity KW - extracellular KW - cardiotoxicity KW - microRNA KW - biomarkers KW - hepatotoxicity KW - Biomarkers -- chemistry KW - Animals KW - Reproducibility of Results KW - Humans KW - Biomarkers -- metabolism KW - MicroRNAs -- metabolism KW - Extracellular Space -- metabolism KW - Drug-Related Side Effects and Adverse Reactions -- pathology KW - MicroRNAs -- biosynthesis KW - MicroRNAs -- chemistry KW - Translational Medical Research -- methods KW - Drug-Related Side Effects and Adverse Reactions -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734282075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Translating+extracellular+microRNA+into+clinical+biomarkers+for+drug-induced+toxicity%3A+from+high-throughput+profiling+to+validation.&rft.au=Wang%2C+Wenjun%3BShi%2C+Qiang%3BMattes%2C+Williams+B%3BMendrick%2C+Donna+L%3BYang%2C+Xi&rft.aulast=Wang&rft.aufirst=Wenjun&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.86 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.86 ER - TY - JOUR T1 - Ionotropic GABA receptor antagonism-induced adverse outcome pathways for potential neurotoxicity biomarkers. AN - 1734281936; 26508561 AB - Antagonism of ionotropic GABA receptors (iGABARs) can occur at three distinct types of receptor binding sites causing chemically induced epileptic seizures. Here we review three adverse outcome pathways, each characterized by a specific molecular initiating event where an antagonist competitively binds to active sites, negatively modulates allosteric sites or noncompetitively blocks ion channel on the iGABAR. This leads to decreased chloride conductance, followed by depolarization of affected neurons, epilepsy-related death and ultimately decreased population. Supporting evidence for causal linkages from the molecular to population levels is presented and differential sensitivity to iGABAR antagonists in different GABA receptors and organisms discussed. Adverse outcome pathways are poised to become important tools for linking mechanism-based biomarkers to regulated outcomes in next-generation risk assessment. JF - Biomarkers in medicine AU - Gong, Ping AU - Hong, Huixiao AU - Perkins, Edward J AD - Environmental Laboratory, US Army Engineer Research & Development Center, 3909 Halls Ferry Road, Vicksburg, MS 39180, USA. ; Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1225 EP - 1239 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - GABA Antagonists KW - Receptors, GABA KW - Index Medicus KW - neurotoxicity biomarker KW - ionotropic γ-aminobutyric acid receptor KW - neurotransmission KW - metabotropic GABA receptor KW - chloride channel KW - risk assessment KW - epileptic seizure KW - cross-species extrapolation KW - antagonist KW - adverse outcome pathway KW - Animals KW - Humans KW - Receptors, GABA -- metabolism KW - Nervous System -- drug effects KW - GABA Antagonists -- adverse effects KW - Nervous System -- metabolism KW - Biomarkers -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Ionotropic+GABA+receptor+antagonism-induced+adverse+outcome+pathways+for+potential+neurotoxicity+biomarkers.&rft.au=Gong%2C+Ping%3BHong%2C+Huixiao%3BPerkins%2C+Edward+J&rft.aulast=Gong&rft.aufirst=Ping&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1225&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.58 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.58 ER - TY - JOUR T1 - Circulating mitochondrial biomarkers for drug-induced liver injury. AN - 1734281872; 26507261 AB - Liver mitochondria affected by drugs can be released into circulation and serve as biomarkers for drug-induced liver injury (DILI). The tissue specificity of ALT was improved by differentiating cytosolic ALT1 and mitochondrial ALT2 isoforms released in circulation. Prior to ALT elevation, mitochondrial cytochrome c, OCT, GLDH, CPS1 and DNA were increased in circulation following DILI. The baseline expression of mt-Nd6 was predictive of individual DILI susceptibility in animals. As mitochondrial DILI biomarkers appeared to be drug or species dependent, they might have value in clinical scenarios when culprit drugs are established, but may not be ideal tools to assess DILI potentials of new drugs. JF - Biomarkers in medicine AU - Shi, Qiang AU - Yang, Xi AU - Mattes, William B AU - Mendrick, Donna L AU - Harrill, Alison H AU - Beger, Richard D AD - Division of Systems Biology, National Center for Toxicological Research, Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Regulatory Activities, National Center for Toxicological Research, Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Department of Environmental & Occupational Health, The University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1215 EP - 1223 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - Mitochondrial Proteins KW - Index Medicus KW - biomarker KW - mitochondrion KW - acetaminophen KW - drug-induced liver injury KW - hepatotoxicity KW - Animals KW - Humans KW - Mitochondrial Proteins -- blood KW - Metabolomics KW - Genomics KW - Chemical and Drug Induced Liver Injury -- blood KW - Chemical and Drug Induced Liver Injury -- pathology KW - Chemical and Drug Induced Liver Injury -- genetics KW - Mitochondria -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Biomarkers -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Circulating+mitochondrial+biomarkers+for+drug-induced+liver+injury.&rft.au=Shi%2C+Qiang%3BYang%2C+Xi%3BMattes%2C+William+B%3BMendrick%2C+Donna+L%3BHarrill%2C+Alison+H%3BBeger%2C+Richard+D&rft.aulast=Shi&rft.aufirst=Qiang&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1215&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.59 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.59 ER - TY - JOUR T1 - NETBAGs: a network-based clustering approach with gene signatures for cancer subtyping analysis. AN - 1734281766; 26501477 AB - To evaluate gene signature and network-based approach for cancer subtyping and classification. Here we introduced NETwork Based clustering Approach with Gene signatures (NETBAGs) algorithm, which clustered samples based on gene signatures and identified molecular markers based on their significantly expressed gene network profiles. Applying NETBAGs to multiple independent breast cancer datasets, we demonstrated that the clustering results were highly associated with the clinical subtypes and clearly revealed the genomic diversity of breast cancer samples. NETBAGs algorithm is able to classify samples by their genomic signatures into clinically significant phenotypes so that potential biomarkers can be identified. The approach may contribute to cancer research and clinical study of complex diseases. JF - Biomarkers in medicine AU - Wu, Leihong AU - Liu, Zhichao AU - Xu, Joshua AU - Chen, Minjun AU - Fang, Hong AU - Tong, Weida AU - Xiao, Wenming AD - Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. ; Office of Scientific Coordination, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1053 EP - 1065 VL - 9 IS - 11 KW - ERBB2 protein, human KW - EC 2.7.10.1 KW - Receptor, ErbB-2 KW - Index Medicus KW - expression KW - RNA-seq KW - cancer subtyping KW - cluster KW - gene network KW - microarray KW - Triple Negative Breast Neoplasms -- diagnosis KW - Genetic Variation KW - Gene Expression Profiling KW - Triple Negative Breast Neoplasms -- classification KW - Receptor, ErbB-2 -- metabolism KW - Triple Negative Breast Neoplasms -- genetics KW - Humans KW - Prognosis KW - Algorithms KW - Cluster Analysis KW - Genomics KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- diagnosis KW - Gene Regulatory Networks KW - Computational Biology -- methods KW - Breast Neoplasms -- metabolism KW - Breast Neoplasms -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=NETBAGs%3A+a+network-based+clustering+approach+with+gene+signatures+for+cancer+subtyping+analysis.&rft.au=Wu%2C+Leihong%3BLiu%2C+Zhichao%3BXu%2C+Joshua%3BChen%2C+Minjun%3BFang%2C+Hong%3BTong%2C+Weida%3BXiao%2C+Wenming&rft.aulast=Wu&rft.aufirst=Leihong&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1053&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.96 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.96 ER - TY - JOUR T1 - Biomarker identification from next-generation sequencing data for pathogen bacteria characterization and surveillance. AN - 1734281647; 26501894 AB - The purpose was to develop an analytical pipeline for specific gene analysis and biomarker discovery from next generation sequencing (NGS) data. As a test case, the fliC gene reference sequences of 24 Salmonella enterica strains of 13 serotypes and NGS reads of 32 serovar Newport, 48 Montevideo and 115 Enteritidis outbreak isolates were retrieved from the National Center for Biotechnology Information database. Establishment of an analytical pipeline consisting of four steps: reference sequences retrieval and template sequence determination; NGS sequence reads retrieval; multiple sequence alignments and phylogenetic analysis; data mining and biomarker discovery. The pipeline developed provides an effective bioinformatics tool for genetic diversity clarification and marker sequences discovery for pathogen characterization and surveillance. JF - Biomarkers in medicine AU - Zhao, Weizhong AU - Chen, James J AU - Foley, Steven AU - Wang, Yuping AU - Zhao, Shaohua AU - Basinger, John AU - Zou, Wen AD - Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. ; Division of Microbiology, National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Rd., Jefferson, AR 72079, USA. ; Division of Animal & Food Microbiology, Office of Research, Center for Veterinary Medicine, US Food & Drug Administration, Laurel, MD 20993, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1253 EP - 1264 VL - 9 IS - 11 KW - Bacterial Proteins KW - 0 KW - Biomarkers KW - Index Medicus KW - Salmonella serotypes KW - biomarker KW - bioinformatics pipeline KW - gene diversity KW - next-generation sequencing analysis KW - fliC gene KW - Phylogeny KW - Bacterial Proteins -- genetics KW - Humans KW - Genomics KW - Salmonella enterica -- isolation & purification KW - Salmonella enterica -- genetics KW - Biomarkers -- metabolism KW - Salmonella enterica -- metabolism KW - High-Throughput Nucleotide Sequencing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Biomarker+identification+from+next-generation+sequencing+data+for+pathogen+bacteria+characterization+and+surveillance.&rft.au=Zhao%2C+Weizhong%3BChen%2C+James+J%3BFoley%2C+Steven%3BWang%2C+Yuping%3BZhao%2C+Shaohua%3BBasinger%2C+John%3BZou%2C+Wen&rft.aulast=Zhao&rft.aufirst=Weizhong&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1253&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.88 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.88 ER - TY - JOUR T1 - Molecular regulation of miRNAs and potential biomarkers in the progression of hepatic steatosis to NASH. AN - 1734281488; 26506944 AB - Increasing evidence suggests that microRNAs regulate diverse biological functions in the liver and play a very important function in metabolic-related disorders such as nonalcoholic fatty liver disease via regulating their target genes expression. In this review, we summarized the most recent progress in identification of miRNAs involving in the progression of liver steatosis and discussed the possible mechanisms by which miRNAs contribute to the diverse pathogenic liver injuries. We provide insights into the functional network of miRNAs by connecting miRNAs, their targets and biological pathways associated to hepatic steatosis and fibrosis, with important implications for our understanding of phenotypic-based disease pathogenesis. We also discuss the possible roles and challenges of miRNAs as biomarkers for drug-induced liver injury. JF - Biomarkers in medicine AU - Wang, Yuping AU - Liu, Zhichao AU - Zou, Wen AU - Hong, Huixiao AU - Fang, Hong AU - Tong, Weida AD - Division of Bioinformatics & Biostatistics, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Office of Scientific Coordination, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR 72079, USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1189 EP - 1200 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - MicroRNAs KW - Peroxisome Proliferator-Activated Receptors KW - Index Medicus KW - biomarker KW - drug-induced liver disease KW - steatosis KW - miRNA KW - nonalcoholic fatty liver disease KW - fibrosis KW - steatohepatitis KW - Liver Cirrhosis -- pathology KW - Animals KW - Humans KW - Liver Cirrhosis -- metabolism KW - Biomarkers -- metabolism KW - Peroxisome Proliferator-Activated Receptors -- metabolism KW - Liver Cirrhosis -- genetics KW - Non-alcoholic Fatty Liver Disease -- genetics KW - Non-alcoholic Fatty Liver Disease -- metabolism KW - MicroRNAs -- metabolism KW - MicroRNAs -- genetics KW - Disease Progression KW - Non-alcoholic Fatty Liver Disease -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734281488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=Molecular+regulation+of+miRNAs+and+potential+biomarkers+in+the+progression+of+hepatic+steatosis+to+NASH.&rft.au=Wang%2C+Yuping%3BLiu%2C+Zhichao%3BZou%2C+Wen%3BHong%2C+Huixiao%3BFang%2C+Hong%3BTong%2C+Weida&rft.aulast=Wang&rft.aufirst=Yuping&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.70 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.70 ER - TY - JOUR T1 - HLADR: a database system for enhancing the discovery of biomarkers for predicting human leukocyte antigen-mediated idiosyncratic adverse drug reactions. AN - 1734280565; 26501190 AB - To establish a database for the associations between idiosyncratic drug reactions (IDRs) and human leukocyte antigens (HLAs) and to systematically assess the characteristics of the drug-HLA associations. Electronic databases were searched to extensively identify drug-HLA association studies from 1966 to present. A drug-HLA-IDR database, HLADR, was created. The drug-HLA relationship network clearly reflected an ethnicity dependency of the associations. The positive predictive values and the negative predictive values demonstrated that other potential factors may also regulate the occurrence of HLA-specific IDRs. Constructing studies with samples from homogeneous ethnic groups and identifying cofactors that affect negative predictive values and positive predictive values will become necessary to enhance the predictability of HLA biomarkers for future research on IDRs. JF - Biomarkers in medicine AU - Du, Tingting AU - Yang, Lun AU - Luo, Heng AU - Zhou, Peng AU - Mei, Hu AU - Xuan, Jiekun AU - Xing, Qinghe AU - Ning, Baitang AU - Mendrick, Donna L AU - Shi, Leming AD - Center for Pharmacogenomics & State Key Laboratory of Genetic Engineering, School of Life Sciences & School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China. ; National Center for Toxicological Research, US Food & Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Institutes of Biomedical Science, Fudan University, 138 Shanghai Medical School Road, Shanghai 200032, China. Y1 - 2015 PY - 2015 DA - 2015 SP - 1079 EP - 1093 VL - 9 IS - 11 KW - Biomarkers KW - 0 KW - HLA Antigens KW - Index Medicus KW - human leukocyte antigen KW - idiosyncratic drug reactions KW - pharmacogenomics KW - association KW - biomarkers KW - Alleles KW - Humans KW - Biomarkers -- metabolism KW - HLA Antigens -- genetics KW - Drug-Related Side Effects and Adverse Reactions -- genetics KW - Drug-Related Side Effects and Adverse Reactions -- diagnosis KW - Computational Biology -- methods KW - Databases, Factual KW - Drug-Related Side Effects and Adverse Reactions -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1734280565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomarkers+in+medicine&rft.atitle=HLADR%3A+a+database+system+for+enhancing+the+discovery+of+biomarkers+for+predicting+human+leukocyte+antigen-mediated+idiosyncratic+adverse+drug+reactions.&rft.au=Du%2C+Tingting%3BYang%2C+Lun%3BLuo%2C+Heng%3BZhou%2C+Peng%3BMei%2C+Hu%3BXuan%2C+Jiekun%3BXing%2C+Qinghe%3BNing%2C+Baitang%3BMendrick%2C+Donna+L%3BShi%2C+Leming&rft.aulast=Du&rft.aufirst=Tingting&rft.date=2015-01-01&rft.volume=9&rft.issue=11&rft.spage=1079&rft.isbn=&rft.btitle=&rft.title=Biomarkers+in+medicine&rft.issn=1752-0371&rft_id=info:doi/10.2217%2Fbmm.15.98 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-08-30 N1 - Date created - 2015-11-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2217/bmm.15.98 ER - TY - JOUR T1 - The Scientific Basis of Uncertainty Factors Used in Setting Occupational Exposure Limits. AN - 1733188730; 26097979 AB - The uncertainty factor concept is integrated into health risk assessments for all aspects of public health practice, including by most organizations that derive occupational exposure limits. The use of uncertainty factors is predicated on the assumption that a sufficient reduction in exposure from those at the boundary for the onset of adverse effects will yield a safe exposure level for at least the great majority of the exposed population, including vulnerable subgroups. There are differences in the application of the uncertainty factor approach among groups that conduct occupational assessments; however, there are common areas of uncertainty which are considered by all or nearly all occupational exposure limit-setting organizations. Five key uncertainties that are often examined include interspecies variability in response when extrapolating from animal studies to humans, response variability in humans, uncertainty in estimating a no-effect level from a dose where effects were observed, extrapolation from shorter duration studies to a full life-time exposure, and other insufficiencies in the overall health effects database indicating that the most sensitive adverse effect may not have been evaluated. In addition, a modifying factor is used by some organizations to account for other remaining uncertainties-typically related to exposure scenarios or accounting for the interplay among the five areas noted above. Consideration of uncertainties in occupational exposure limit derivation is a systematic process whereby the factors applied are not arbitrary, although they are mathematically imprecise. As the scientific basis for uncertainty factor application has improved, default uncertainty factors are now used only in the absence of chemical-specific data, and the trend is to replace them with chemical-specific adjustment factors whenever possible. The increased application of scientific data in the development of uncertainty factors for individual chemicals also has the benefit of increasing the transparency of occupational exposure limit derivation. Improved characterization of the scientific basis for uncertainty factors has led to increasing rigor and transparency in their application as part of the overall occupational exposure limit derivation process. JF - Journal of occupational and environmental hygiene AU - Dankovic, D A AU - Naumann, B D AU - Maier, A AU - Dourson, M L AU - Levy, L S AD - a Education and Information Division, Centers for Disease Control and Prevention (CDC), National Institute for Occupational Safety and Health (NIOSH) , Cincinnati , Ohio. ; b Global Safety and the Environment, Merck & Co., Inc., Whitehouse Station , New Jersey. ; c University of Cincinnati , College of Medicine, Department of Environmental Health, Cincinnati , Ohio. ; d The Toxicology Excellence for Risk Assessment Center of the University of Cincinnati, College of Medicine, Department of Environmental Health, Toxicology Excellence for Risk Assessment , Cincinnati , Ohio. ; e Institute for Environment, Health, Risks and Futures, Cranfield University, Cranfield, Bedfordshire. Y1 - 2015 PY - 2015 DA - 2015 SP - S55 EP - S68 VL - 12 Suppl 1 KW - Index Medicus KW - adjustment factor KW - uncertainty factor KW - risk assessment KW - occupational exposure KW - Uncertainty KW - Animals KW - No-Observed-Adverse-Effect Level KW - Humans KW - Species Specificity KW - Risk Assessment KW - Occupational Exposure -- standards KW - Toxicology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1733188730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+Scientific+Basis+of+Uncertainty+Factors+Used+in+Setting+Occupational+Exposure+Limits.&rft.au=Dankovic%2C+D+A%3BNaumann%2C+B+D%3BMaier%2C+A%3BDourson%2C+M+L%3BLevy%2C+L+S&rft.aulast=Dankovic&rft.aufirst=D&rft.date=2015-01-01&rft.volume=12+Suppl+1&rft.issue=&rft.spage=S55&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1060325 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-09-23 N1 - Date created - 2015-11-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Risk Anal. 2000 Apr;20(2):245-50 [10859783] Ann Occup Hyg. 2007 Jun;51(4):345-56 [17602208] Regul Toxicol Pharmacol. 2002 Dec;36(3):262-79 [12473411] Risk Anal. 2003 Dec;23(6):1239-55 [14641898] Toxicol Appl Pharmacol. 1972 Apr;21(4):454-63 [5047046] Int Arch Occup Environ Health. 1979 Jan 15;42(3-4):191-201 [422260] Regul Toxicol Pharmacol. 1983 Sep;3(3):224-38 [6356243] J Appl Toxicol. 1984 Oct;4(5):277-80 [6512168] Regul Toxicol Pharmacol. 1985 Jun;5(2):190-6 [4023289] J Occup Med. 1986 Jun;28(6):425-33 [3723215] Regul Toxicol Pharmacol. 2008 Aug;51(3):253-69 [18502550] Toxicol Sci. 2009 Nov;112(1):196-210 [19692668] Crit Rev Toxicol. 2010 Oct;40(9):791-8 [20860525] Regul Toxicol Pharmacol. 2010 Nov;58(2):237-42 [20561553] Toxicol Sci. 2011 Sep;123(1):231-46 [21705714] Regul Toxicol Pharmacol. 2002 Jun;35(3):448-67 [12202058] Toxicol Lett. 2013 Apr 12;218(2):159-65 [23395978] J Occup Environ Hyg. 2015;12 Suppl 1:S7-17 [26252067] J Occup Environ Hyg. 2015;12 Suppl 1:S18-40 [26551218] J Occup Environ Hyg. 2015;12 Suppl 1:S127-44 [26099071] J Occup Environ Hyg. 2015;12 Suppl 1:S99-111 [26302336] J Occup Environ Hyg. 2015;12 Suppl 1:S69-81 [26583908] Regul Toxicol Pharmacol. 1986 Sep;6(3):211-37 [3775081] Risk Anal. 1987 Dec;7(4):415-26 [3444929] Am Ind Hyg Assoc J. 1988 Jun;49(6):309-13 [3400595] Ann Occup Hyg. 1989;33(4):555-62 [2690717] Regul Toxicol Pharmacol. 1990 Jun;11(3):314-30 [2196639] Food Addit Contam. 1991 Mar-Apr;8(2):135-49 [1868926] Toxicol Ind Health. 1992 May-Jun;8(3):171-89 [1502696] Regul Toxicol Pharmacol. 1992 Jun;15(3):291-306 [1509122] Toxicol Lett. 1992 Dec;64-65 Spec No:53-7 [1471206] Regul Toxicol Pharmacol. 1993 Feb;17(1):44-51 [8441828] Food Addit Contam. 1993 May-Jun;10(3):275-305 [8359312] J Toxicol Environ Health. 1995 May;45(1):83-95 [7538596] Regul Toxicol Pharmacol. 1996 Oct;24(2 Pt 1):108-20 [8933624] Risk Anal. 1998 Jun;18(3):271-82 [9664723] Occup Med (Lond). 1999 May;49(4):225-9 [10474913] Crit Rev Toxicol. 1999 Sep;29(5):439-90 [10521133] Environ Res. 2007 May;104(1):108-27 [17166493] Crit Rev Toxicol. 2007 Jun;37(5):355-73 [17612951] Regul Toxicol Pharmacol. 2012 Aug;63(3):461-70 [22683397] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1060325 ER - TY - JOUR T1 - Detection by coupled LC-photodiode array detection and high-resolution Orbitrap MS of dimethyl and diethyl yellow dyes used illegally in processed soymilk curd AN - 1732815397; PQ0002209788 AB - An efficient non-target dye-screening system consisting of a liquid chromatography photodiode array coupled with a high-resolution mass spectrometer (HRMS) is described. Visible absorption spectroscopy assisted in locating the peak of an unknown dye in HRMS chromatograms which allowed the accurate molecular weight of the unknown to be obtained. In a study of the adulteration of processed soymilk curd (tofu) with dimethyl yellow, an unexpected unknown dye was discovered. The compound was further purified by gel permeation chromatography and identified by HRMS and proton nuclear magnetic resonance (NMR) as diethyl yellow (solvent yellow 56). This is the first time that diethyl yellow has been reported in foods. The authentic diethyl yellow was then purchased and used as a quantitative standard. Tofu products and their ingredients associated with tofu processing were surveyed. Analysis showed the source of diethyl yellow could be traced to emulsifiers used as ingredient in tofu products. Surveillance work found the concentrations of diethyl yellow ranged from several mu g kg super(-1) (ppb) in the tofu products to up to hundreds of mg kg super(-1) (ppm) in the emulsifiers. JF - Food Additives & Contaminants: Part A - Chemistry, Analysis, Control, Exposure & Risk Assessment AU - Fang, Mingchih AU - Tsai, Chia-Fen AU - Kuo, Ching-Hao AU - Cheng, Hwei-Fang AD - Taiwan Food and Drug Administration, Taipei City, Taiwan PY - 2015 SP - 1730 EP - 1736 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 32 IS - 10 SN - 1944-0049, 1944-0049 KW - Risk Abstracts KW - Risk assessment KW - Food additives KW - Absorption spectroscopy KW - Dyes KW - Liquid chromatography KW - Chromatography KW - Solvents KW - NMR KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732815397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.atitle=Detection+by+coupled+LC-photodiode+array+detection+and+high-resolution+Orbitrap+MS+of+dimethyl+and+diethyl+yellow+dyes+used+illegally+in+processed+soymilk+curd&rft.au=Fang%2C+Mingchih%3BTsai%2C+Chia-Fen%3BKuo%2C+Ching-Hao%3BCheng%2C+Hwei-Fang&rft.aulast=Fang&rft.aufirst=Mingchih&rft.date=2015-01-01&rft.volume=32&rft.issue=10&rft.spage=1730&rft.isbn=&rft.btitle=&rft.title=Food+Additives+%26+Contaminants%3A+Part+A+-+Chemistry%2C+Analysis%2C+Control%2C+Exposure+%26+Risk+Assessment&rft.issn=19440049&rft_id=info:doi/10.1080%2F19440049.2015.1055830 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Risk assessment; Absorption spectroscopy; Food additives; Dyes; Chromatography; Liquid chromatography; Solvents; NMR DO - http://dx.doi.org/10.1080/19440049.2015.1055830 ER - TY - JOUR T1 - Review of methods to measure internal contamination in an emergency AN - 1732810544; PQ0002108386 AB - In the event of a radiation emergency, people close to the site of the incident may be exposed to radiation by external exposure, or as a result of intakes of radioactive material. For these incidents it may be necessary to monitor members of the public both for external and internal contamination. This work reviews currently available equipment for the assessment of internal exposure following an emergency. It concentrates on incidents involving the spread of radioactive material and on contamination by radionuclides which emit penetrating radiation. It is essential that this monitoring is carried out as soon as possible so that people who have been exposed at a level which could have an effect on health can be identified and receive prompt medical assessment. Proposed action levels to identify people who need medical attention are reviewed to determine the required sensitivity of monitoring equipment. For releases containing gamma-ray emitting radionuclides the best means of measuring internal contamination is to use detectors placed close to the body (whole body or partial body monitoring). Laboratory based whole body monitors could be used but these may well be inconveniently located and so equipment which can be deployed to the site of an incident has been developed and these are described. The need for rapid selection and prioritisation of people for monitoring, methods to deal with potentially high numbers of contaminated people and the requirement for a means of rapidly interpreting monitoring information are also discussed. It has been found that for many types of incidents and scenarios, systems based on unshielded high-resolution detectors and hand-held instruments do have the required sensitivity to identify people who require medical assessment. JF - Journal of Radiological Protection AU - Youngman, M J AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, Oxon, OX11 0RQ, UK, mike.youngman@phe.gov.uk Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - R1 EP - R15 PB - IOP Publishing, The Public Ledger Building, Suite 929 Philadelphia PA 19106 United States VL - 35 IS - 2 SN - 0952-4746, 0952-4746 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - internal KW - contamination KW - emergencies KW - monitoring KW - screening KW - thyroid KW - whole body KW - Sensitivity KW - Monitoring methods KW - Radiation KW - Contamination KW - Reviews KW - Radioactive materials KW - Radioisotopes KW - Monitoring instruments KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732810544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Radiological+Protection&rft.atitle=Review+of+methods+to+measure+internal+contamination+in+an+emergency&rft.au=Youngman%2C+M+J&rft.aulast=Youngman&rft.aufirst=M&rft.date=2015-01-01&rft.volume=35&rft.issue=2&rft.spage=R1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Radiological+Protection&rft.issn=09524746&rft_id=info:doi/10.1088%2F0952-4746%2F35%2F2%2FR1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Sensitivity; Monitoring methods; Contamination; Radiation; Reviews; Radioactive materials; Radioisotopes; Monitoring instruments DO - http://dx.doi.org/10.1088/0952-4746/35/2/R1 ER - TY - JOUR T1 - Musculoskeletal disorders and associated healthcare costs among family members of injured workers AN - 1727696610; PQ0002166930 AB - Background Research has infrequently looked beyond the injured worker when gauging the burden of occupational injury. Objectives We explored the relationship between occupational injury and musculoskeletal disorders (MSDs) among family members of injured workers. Data and Methods We used 2005 and 2006 Truven Health Analytics databases, which contain information on workers' compensation and family healthcare claims. We used descriptive analyses, and negative binomial and two-part models. Results Family members of severely injured workers had a 15% increase in the total number of MSD outpatient claims and a 34% increase in the mean cost of MSD claims compared to family members of non-severely injured workers within 3 months after injury. Extrapolating cost results to the national level implies that severe occupational injury would be associated with between $29 and $33 million additional cost of family member outpatient MSD claims. Conclusion Occupational injury can impose a formerly unrecognized health burden on family members of injured workers. Am. J. Ind. Med. 58:1205-1216, 2015. Published 2015. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Asfaw, Abay AU - Pana-Cryan, Regina AU - Bushnell, Tim AU - Sauter, Steven AD - Centers for Disease Control and Prevention (CDC)-National Institute for Occupational Safety and Health (NIOSH), Economic Research and Support Office (ERSO), Washington, District of Columbia. PY - 2015 SP - 1205 EP - 1216 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 11 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Workers' compensation KW - USA KW - Musculoskeletal system KW - Health care KW - Injuries KW - Occupational safety KW - Occupational health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727696610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Musculoskeletal+disorders+and+associated+healthcare+costs+among+family+members+of+injured+workers&rft.au=Asfaw%2C+Abay%3BPana-Cryan%2C+Regina%3BBushnell%2C+Tim%3BSauter%2C+Steven&rft.aulast=Asfaw&rft.aufirst=Abay&rft.date=2015-01-01&rft.volume=58&rft.issue=11&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22500 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Musculoskeletal system; Injuries; Health care; Occupational safety; Occupational health; USA DO - http://dx.doi.org/10.1002/ajim.22500 ER - TY - JOUR T1 - Styrene-associated health outcomes at a windblade manufacturing plant AN - 1727680917; PQ0002166935 AB - Background Health risks of using styrene to manufacture windblades for the green energy sector are unknown. Methods Using data collected from 355 (73%) current windblade workers and regression analysis, we investigated associations between health outcomes and styrene exposure estimates derived from urinary styrene metabolites. Results The median current styrene exposure was 53.6mg/g creatinine (interquartile range: 19.5-94.4). Color blindness in men and women (standardized morbidity ratios 2.3 and 16.6, respectively) was not associated with exposure estimates, but was the type previously reported with styrene. Visual contrast sensitivity decreased and chest tightness increased (odds ratio 2.9) with increasing current exposure. Decreases in spirometric parameters and FeNO, and increases in the odds of wheeze and asthma-like symptoms (odds ratios 1.3 and 1.2, respectively) occurred with increasing cumulative exposure. Conclusions Despite styrene exposures below the recommended 400mg/g creatinine, visual and respiratory effects indicate the need for additional preventative measures in this industry. Am. J. Ind. Med. 58:1150-1159, 2015. JF - American Journal of Industrial Medicine AU - McCague, Anna-Binney AU - Cox-Ganser, Jean M AU - Harney, Joshua M AU - Alwis, KUdeni AU - Blount, Benjamin C AU - Cummings, Kristin J AU - Edwards, Nicole AU - Kreiss, Kathleen AD - Field Studies Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. PY - 2015 SP - 1150 EP - 1159 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 11 SN - 0271-3586, 0271-3586 KW - Sustainability Science Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Styrene KW - Manufacturing industry KW - Health risks KW - Sensitivity KW - Currents KW - Urine KW - Green development KW - Standards KW - Metabolites KW - Morbidity KW - Occupational exposure KW - M3 1010:Issues in Sustainable Development KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727680917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Styrene-associated+health+outcomes+at+a+windblade+manufacturing+plant&rft.au=McCague%2C+Anna-Binney%3BCox-Ganser%2C+Jean+M%3BHarney%2C+Joshua+M%3BAlwis%2C+KUdeni%3BBlount%2C+Benjamin+C%3BCummings%2C+Kristin+J%3BEdwards%2C+Nicole%3BKreiss%2C+Kathleen&rft.aulast=McCague&rft.aufirst=Anna-Binney&rft.date=2015-01-01&rft.volume=58&rft.issue=11&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22516 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Styrene; Sensitivity; Health risks; Manufacturing industry; Currents; Urine; Green development; Metabolites; Standards; Occupational exposure; Morbidity DO - http://dx.doi.org/10.1002/ajim.22516 ER - TY - JOUR T1 - Use of Dipeptidyl-Peptidase-4 Inhibitors and the Risk of Pneumonia: A Population-Based Cohort Study. AN - 1722931374; 26468883 AB - Dipeptidyl-peptidase-4 inhibitors (DPP4Is) are drugs for the treatment of type 2 diabetes mellitus (T2DM). There is increasing evidence that DPP4Is may result in suppression of the immune system and may increase the risk of infections such as pneumonia. Aim of this study was to evaluate the association between the use of DPP4Is and the risk of pneumonia in a population-based study. We conducted a population-based cohort study using data from the world's largest primary care database, the UK Clinical Practice Research Datalink (CPRD). We selected all users of non-insulin antidiabetic drugs (NIADs), including DPP4Is, between 2007 and 2012. To each NIAD user, we matched randomly selected non-users. The NIAD user's first prescription defined the index date, which was then assigned to the matched non-users. Patients were followed from their first prescription until end of data collection or the first event of pneumonia, whichever came first. Cox regression analysis estimated the association between pneumonia and current use of DPP4Is versus 1) current use of other NIADs and 2) non-users. DPP4I use was then stratified to daily and cumulative dose. Analyses were statistically adjusted for age, sex, lifestyle factors and comorbidities and concomitant use of various other drugs. Risk of pneumonia was not increased with current DPP4I use versus use of other NIADs, adjusted Hazard Ratio (HR) 0.70; 95% Confidence Interval (CI) 0.55-0.91. Also higher cumulative doses or daily doses did not further increase risk of pneumonia. We found no increased risk of pneumonia in T2DM patients using DPP4Is compared to T2DM patients using other NIADs. Our finding is in line with direct and indirect evidence from observational studies and RCTs. There is probably no need to avoid prescribing of DPP4Is to elderly patients who are at risk of pneumonia. JF - PloS one AU - Wvan der Zanden, Rogier AU - de Vries, Frank AU - Lalmohamed, Arief AU - Driessen, Johanna H M AU - de Boer, Anthonius AU - Rohde, Gernot AU - Neef, Cees AU - den Heijer, Casper AD - Department of Clinical Pharmacy and Toxicology, Maastricht University, Medical Centre+, Maastricht, Netherlands; Care and Public Health Research Institute (CAPHRI), Maastricht, Netherlands. ; Department of Clinical Pharmacy and Toxicology, Maastricht University, Medical Centre+, Maastricht, Netherlands; Care and Public Health Research Institute (CAPHRI), Maastricht, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands. ; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, Netherlands. ; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands; Department of Clinical Pharmacy, University Medical Centre Utrecht, Utrecht, The Netherlands. ; Department of Respiratory Medicine, Maastricht University, Medical Centre+, Maastricht, Netherlands. ; Department of Sexual Health, Infectious Diseases and Environmental Health, Public Health Service South Limburg, Geleen, Netherlands; Department of Microbiology, Maastricht University Medical Centre+, Maastricht, Netherlands. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 10 KW - Dipeptidyl-Peptidase IV Inhibitors KW - 0 KW - Index Medicus KW - Diabetes Mellitus, Type 2 -- drug therapy KW - Young Adult KW - Risk KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Pneumonia -- chemically induced KW - Dipeptidyl-Peptidase IV Inhibitors -- adverse effects KW - Dipeptidyl-Peptidase IV Inhibitors -- therapeutic use KW - Pneumonia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722931374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Use+of+Dipeptidyl-Peptidase-4+Inhibitors+and+the+Risk+of+Pneumonia%3A+A+Population-Based+Cohort+Study.&rft.au=Wvan+der+Zanden%2C+Rogier%3Bde+Vries%2C+Frank%3BLalmohamed%2C+Arief%3BDriessen%2C+Johanna+H+M%3Bde+Boer%2C+Anthonius%3BRohde%2C+Gernot%3BNeef%2C+Cees%3Bden+Heijer%2C+Casper&rft.aulast=Wvan+der+Zanden&rft.aufirst=Rogier&rft.date=2015-01-01&rft.volume=10&rft.issue=10&rft.spage=e0139367&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0139367 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-06-20 N1 - Date created - 2015-10-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Ann N Y Acad Sci. 2007 Sep;1110:402-9 [17911455] Bone. 2014 Nov;68:124-30 [25093264] Diabetes Care. 2014 Aug;37(8):2218-24 [24842984] Eur J Clin Microbiol Infect Dis. 2014 Jul;33(7):1065-79 [24532008] Diabetes Obes Metab. 2012 Dec;14(12):1061-72 [22519906] Mol Cancer Res. 2013 Dec;11(12):1487-96 [24038034] J Clin Endocrinol Metab. 2013 Jun;98(6):2553-61 [23539735] Immunol Rev. 2013 Mar;252(1):156-63 [23405903] Curr Opin Immunol. 2012 Aug;24(4):424-30 [22841348] J Clin Pharm Ther. 2012 Aug;37(4):386-98 [22191695] BMJ. 2012;344:e1369 [22411919] Thorax. 2012 Jan;67(1):71-9 [20729232] Osteoporos Int. 2011 May;22(5):1641-2 [20563562] JAMA. 2007 Jul 11;298(2):194-206 [17622601] Clin Ther. 2006 Oct;28(10):1556-68 [17157112] Thorax. 2006 Nov;61(11):957-61 [16809409] Int J Epidemiol. 2006 Oct;35(5):1301-8 [17053011] Diabetes. 2005 Oct;54(10):2988-94 [16186403] Immunol Rev. 1998 Feb;161:55-70 [9553764] Immunol Rev. 1998 Feb;161:43-53 [9553763] Stat Med. 1991 Apr;10(4):577-81 [2057656] N Engl J Med. 2004 Jun 10;350(24):2487-98 [15190141] Adv Exp Med Biol. 2003;524:165-74 [12675236] Diabetes Obes Metab. 2015 Apr;17(4):379-85 [25581902] Diabetes Care. 2015 Mar;38(3):495-502 [25552419] Curr Med Res Opin. 2009 Oct;25(10):2401-11 [19650754] Cancer Immunol Immunother. 2009 Nov;58(11):1723-47 [19557413] Cochrane Database Syst Rev. 2008;(2):CD006739 [18425967] Br J Clin Pharmacol. 2010 Jan;69(1):4-14 [20078607] Diabetes Care. 2011 Feb;34(2):369-74 [21270195] J Diabetes Complications. 2010 May-Jun;24(3):209-13 [19854074] Br J Gen Pract. 2010 Mar;60(572):e128-36 [20202356] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0139367 ER - TY - JOUR T1 - Investigations into the Immunotoxicity and Allergic Potential Induced by Topical Application of N-Butylbenzenesulfonamide (NBBS) in a Murine Model. AN - 1722425598; 26291892 AB - N-Butylbenzene sulfonamide (NBBS) is a commonly used plasticizer found in numerous products. Due to its extensive use, lack of adequate toxicological data, and suspicion of toxicity based on the presence of structural alerts, it was nominated to the National Toxicology Program for comprehensive toxicological testing. The purpose of this study was to evaluate the potential for hypersensitivity and immune suppression following dermal exposure to NBBS using a murine model. NBBS tested negative in a combined irritancy/local lymph node assay (LLNA), classifying it as nonirritating and nonsensitizing. To estimate the immunosuppressive potential of NBBS, assays that assessed immunotoxicity were performed, including the immumnoglobulin (Ig) M response to T-cell-dependent antigen sheep red blood cells (SRBC), using the plaque-forming cell (PFC) assay and immune cell phenotyping. After a 28-d treatment with NBBS, mice exposed to the lowest concentration (25% NBBS) showed a significant increase in IgM-producing B cells in the spleen. No marked changes were identified in immune cell markers in the lymph node. In contrast to body weight, a significant elevation in kidney and liver weight was observed following dermal exposure to all concentrations of NBBS. These results demonstrate that dermal exposure to NBBS, other than liver and kidney toxicity, did not apparently induce immunotoxicity in a murine model. JF - Journal of toxicology and environmental health. Part A AU - Marrocco, Antonella AU - Meade, B Jean AU - Long, Carrie M AU - Lukomska, Ewa AU - Marshall, Nikki B AU - Anderson, Stacey E AD - a National Institute for Occupational Safety and Health , Morgantown , West Virginia , USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1122 EP - 1132 VL - 78 IS - 17 SN - 1528-7394, 1528-7394 KW - Immunoglobulin G KW - 0 KW - Immunosuppressive Agents KW - Plasticizers KW - Sulfonamides KW - N-butylbenzenesulfonamide KW - 3622-84-2 KW - Index Medicus KW - Animals KW - Administration, Cutaneous KW - Sheep KW - Mice KW - Immunoglobulin G -- immunology KW - Mice, Inbred BALB C KW - Immunosuppressive Agents -- pharmacology KW - Toxicity Tests KW - Spleen -- immunology KW - T-Lymphocytes -- drug effects KW - Spleen -- drug effects KW - T-Lymphocytes -- immunology KW - Female KW - Lymph Nodes -- immunology KW - Sulfonamides -- toxicity KW - Plasticizers -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722425598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+toxicology+and+environmental+health.+Part+A&rft.atitle=Investigations+into+the+Immunotoxicity+and+Allergic+Potential+Induced+by+Topical+Application+of+N-Butylbenzenesulfonamide+%28NBBS%29+in+a+Murine+Model.&rft.au=Marrocco%2C+Antonella%3BMeade%2C+B+Jean%3BLong%2C+Carrie+M%3BLukomska%2C+Ewa%3BMarshall%2C+Nikki+B%3BAnderson%2C+Stacey+E&rft.aulast=Marrocco&rft.aufirst=Antonella&rft.date=2015-01-01&rft.volume=78&rft.issue=17&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=Journal+of+toxicology+and+environmental+health.+Part+A&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2015.1056898 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-13 N1 - Date created - 2015-10-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Antibiot (Tokyo). 2000 Feb;53(2):131-6 [10805572] Toxicology. 2000 May 5;146(2-3):221-7 [10814854] Occup Environ Med. 2003 Feb;60(2):97-103 [12554836] Toxicol Sci. 2003 Sep;75(1):89-98 [12832659] Mar Pollut Bull. 2003 Sep;46(9):1102-10 [12932491] Environ Toxicol Chem. 2004 Sep;23(9):2074-83 [15378981] Fundam Appl Toxicol. 1988 Jan;10(1):2-19 [3280374] Acta Neuropathol. 1991;81(3):235-41 [2058361] Toxicol Lett. 1992 Dec;64-65 Spec No:71-8 [1471226] Ann N Y Acad Sci. 1993 May 28;679:280-7 [8512189] Food Chem Toxicol. 1998 Sep-Oct;36(9-10):831-9 [9737431] Fed Regist. 1999 Mar 23;64(55):14006-7 [10558409] Science. 1963 Apr 26;140(3565):405 [13957684] Food Addit Contam. 2005 Oct;22(10):1012-22 [16227185] Water Res. 2005 Nov;39(19):4735-48 [16280149] Hum Exp Toxicol. 2006 Jul;25(7):387-94 [16898167] Water Environ Res. 2007 Feb;79(2):156-67 [17370841] Toxicol Sci. 2007 Jun;97(2):253-64 [17369196] Pediatr Dermatol. 2008 Jan-Feb;25(1):1-6 [18304144] Dermatol Clin. 2012 Jan;30(1):87-98, viii [22117870] J Immunotoxicol. 2013 Jan-Mar;10(1):59-66 [22953780] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15287394.2015.1056898 ER - TY - JOUR T1 - Small airway epithelial cells exposure to printer-emitted engineered nanoparticles induces cellular effects on human microvascular endothelial cells in an alveolar-capillary co-culture model AN - 1722175855; PQ0002055775 AB - The printer is one of the most common office equipment. Recently, it was reported that toner formulations for printing equipment constitute nano-enabled products (NEPs) and contain engineered nanomaterials (ENMs) that become airborne during printing. To date, insufficient research has been performed to understand the potential toxicological properties of printer-emitted particles (PEPs) with several studies using bulk toner particles as test particles. These studies demonstrated the ability of toner particles to cause chronic inflammation and fibrosis in animal models. However, the toxicological implications of inhalation exposures to ENMs emitted from laser printing equipment remain largely unknown The present study investigates the toxicological effects of PEPs using an in vitro alveolar-capillary co-culture model with Human Small Airway Epithelial Cells (SAEC) and Human Microvascular Endothelial Cells (HMVEC). Our data demonstrate that direct exposure of SAEC to low concentrations of PEPs (0.5 and 1.0 mu g/mL) caused morphological changes of actin remodeling and gap formations within the endothelial monolayer. Furthermore, increased production of reactive oxygen species (ROS) and angiogenesis were observed in the HMVEC. Analysis of cytokine and chemokine levels demonstrates that interleukin (IL)-6 and MCP-1 may play a major role in the cellular communication observed between SAEC and HMVEC and the resultant responses in HMVEC. These data indicate that PEPs at low, non-cytotoxic exposure levels are bioactive and affect cellular responses in an alveolar-capillary co-culture model, which raises concerns for potential adverse health effects. JF - Nanotoxicology AU - Sisler, Jennifer D AU - Pirela, Sandra V AU - Friend, Sherri AU - Farcas, Mariana AU - Schwegler-Berry, Diane AU - Shvedova, Anna AU - Castranova, Vincent AU - Demokritou, Philip AU - Qian, Yong AD - Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 769 EP - 779 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 9 IS - 6 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Inhalation KW - Microvasculature KW - Epithelial cells KW - Chemokines KW - Data processing KW - Printing KW - Monocyte chemoattractant protein 1 KW - Interleukins KW - Angiogenesis KW - Animal models KW - Inflammation KW - Endothelial cells KW - Reactive oxygen species KW - Actin KW - Lasers KW - Cell interactions KW - nanoparticles KW - nanotechnology KW - Respiratory tract KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722175855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Small+airway+epithelial+cells+exposure+to+printer-emitted+engineered+nanoparticles+induces+cellular+effects+on+human+microvascular+endothelial+cells+in+an+alveolar-capillary+co-culture+model&rft.au=Sisler%2C+Jennifer+D%3BPirela%2C+Sandra+V%3BFriend%2C+Sherri%3BFarcas%2C+Mariana%3BSchwegler-Berry%2C+Diane%3BShvedova%2C+Anna%3BCastranova%2C+Vincent%3BDemokritou%2C+Philip%3BQian%2C+Yong&rft.aulast=Sisler&rft.aufirst=Jennifer&rft.date=2015-01-01&rft.volume=9&rft.issue=6&rft.spage=769&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2014.976603 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Inhalation; Epithelial cells; Microvasculature; Chemokines; Monocyte chemoattractant protein 1; Printing; Data processing; Animal models; Angiogenesis; Interleukins; Inflammation; Endothelial cells; Reactive oxygen species; Lasers; Actin; Cell interactions; nanoparticles; Respiratory tract; nanotechnology DO - http://dx.doi.org/10.3109/17435390.2014.976603 ER - TY - JOUR T1 - Prediction of drug clearance in children: a review of different methodologies AN - 1722174980; PQ0002060396 AB - Introduction: Children are not small adults because the differences between adults and children are not simply due to body weight, but also due to physiological and biochemical differences. Hence, dosing in children should not be a 'small adult dose'. During pediatric drug development, selection of a suitable dose for the first-in-children clinical study (Pharmacokinetic [PK], safety and efficacy) is of utmost importance. Considering the importance of clearance in dose selection, a lot of approaches have been suggested for the prediction of drug clearance in children. This review examines many proposed methods for the prediction of drug clearance in the pediatric population and highlights the application and limitations of these proposed methods. Areas covered: In this review, different methods for the prediction of drug clearance in the pediatric population are discussed. These methods include allometric models, population-based pharmacometric models and physiologically based PK models. Expert opinion: All models discussed here have uncertainties in their predictive power and should be only used as exploratory tools during pediatric drug development. Allometric models, if used with knowledge and understanding, is a powerful tool for the prediction of drug clearance in pediatric population. JF - Expert Opinion on Drug Metabolism and Toxicology AU - Mahmood, Iftekhar AD - Center for Biologic Evaluation and Research, Office of Blood Review and Research (OBRR), Division of Hematology, US Food and Drug Administration, Silver Spring, MD, USA Y1 - 2015 PY - 2015 DA - 2015 SP - 573 EP - 587 PB - Informa Healthcare VL - 11 IS - 4 SN - 1742-5255, 1742-5255 KW - Toxicology Abstracts KW - allometric models KW - children KW - drug clearance KW - physiological models KW - population-based pharmacometric models KW - Body weight KW - Pediatrics KW - Reviews KW - Drug development KW - Children KW - Drugs KW - Pharmacokinetics KW - Models KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722174980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.atitle=Prediction+of+drug+clearance+in+children%3A+a+review+of+different+methodologies&rft.au=Mahmood%2C+Iftekhar&rft.aulast=Mahmood&rft.aufirst=Iftekhar&rft.date=2015-01-01&rft.volume=11&rft.issue=4&rft.spage=573&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.2015.1019463 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Body weight; Pediatrics; Reviews; Drug development; Children; Drugs; Pharmacokinetics; Models DO - http://dx.doi.org/10.1517/17425255.2015.1019463 ER - TY - JOUR T1 - The role for microRNAs in drug toxicity and in safety assessment AN - 1722174936; PQ0002060398 AB - Introduction: Adverse drug reactions present significant challenges that impact pharmaceutical development and are major burdens to public health services worldwide. In response to this need, the field of toxicology is rapidly expanding to identify key pathways involved in drug toxicity. Areas covered: MicroRNAs (miRNAs) are a class of small evolutionary conserved endogenous non-coding RNAs that regulate the translation of protein-coding genes. A wide range of toxicants alter miRNA levels in target organs and these altered miRNAs can also be detected in easily accessible biological fluids. This, combined with an early miRNA response to toxic insults and miRNA stability, substantiates the potential for these small molecules to be useful biomarkers for drug safety assessment. Expert opinion: miRNAs are early indicators and useful tools to detect drug-induced toxicity. Incorporation of miRNA profiling into the drug safety testing process will complement currently used techniques and may substantially enhance drug safety. With the increasing interests in translational research, the field of miRNA biomarker research will continue to expand and become an important part of the investigation of human drug toxicity. JF - Expert Opinion on Drug Metabolism and Toxicology AU - Marrone, April K AU - Beland, Frederick A AU - Pogribny, Igor P AD - FDA-National Center for Toxicological Research, Division of Biochemical Toxicology, Jefferson, AR, USA Y1 - 2015 PY - 2015 DA - 2015 SP - 601 EP - 611 PB - Informa Healthcare VL - 11 IS - 4 SN - 1742-5255, 1742-5255 KW - Toxicology Abstracts KW - adverse drug reactions KW - drug toxicity KW - microRNAs KW - safety assessment KW - Evolutionary conservation KW - Translation KW - Toxicants KW - miRNA KW - non-coding RNA KW - Drug development KW - Development KW - Toxicity KW - Drug screening KW - biomarkers KW - Public health KW - Pharmaceuticals KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722174936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.atitle=The+role+for+microRNAs+in+drug+toxicity+and+in+safety+assessment&rft.au=Marrone%2C+April+K%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Marrone&rft.aufirst=April&rft.date=2015-01-01&rft.volume=11&rft.issue=4&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.2015.1021687 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Translation; Evolutionary conservation; Toxicants; miRNA; non-coding RNA; Drug development; Toxicity; Development; Drug screening; biomarkers; Public health; Pharmaceuticals; Drugs DO - http://dx.doi.org/10.1517/17425255.2015.1021687 ER - TY - JOUR T1 - Epidemiological Scenario of Dengue in Brazil AN - 1722170464; PQ0002028848 AB - Dengue is the most important reemerging mosquito-borne viral disease worldwide. It is caused by any of four Dengue virus types or serotypes (DENV-1 to DENV-4) and is transmitted by mosquitoes from the genus Aedes . Ecological changes have favored the geographic expansion of the vector and, since the dengue pandemic in the Asian and Pacific regions, the infection became widely distributed worldwide, reaching Brazil in 1845. The incidence of dengue in Brazil has been frequently high, and the number of cases in the country has at some point in time represented up to 60% of the dengue reported cases worldwide. This review addresses vector distribution, dengue outbreaks, circulating serotypes and genotypes, and prevention approaches being utilized in Brazil. JF - BioMed Research International AU - Fares, Rafaelle CG AU - Souza, Katia PR AU - Anez, German AU - Rios, Maria AD - United States Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993, USA, maria.rios@fda.hhs.gov Y1 - 2015/01// PY - 2015 DA - January 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Entomology Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Dengue virus KW - Aedes KW - Human diseases KW - Geographical distribution KW - Serotypes KW - Vectors KW - Hosts KW - Genotypes KW - Infection KW - Public health KW - Disease transmission KW - pandemics KW - Viral diseases KW - Dengue KW - I, Pacific KW - ASW, Brazil KW - Aquatic insects KW - V 22410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Z 05360:Genetics and Evolution KW - Q5 08524:Public health, medicines, dangerous organisms KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722170464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Epidemiological+Scenario+of+Dengue+in+Brazil&rft.au=Fares%2C+Rafaelle+CG%3BSouza%2C+Katia+PR%3BAnez%2C+German%3BRios%2C+Maria&rft.aulast=Fares&rft.aufirst=Rafaelle&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F321873 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 3 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Geographical distribution; Human diseases; Viral diseases; Genotypes; Hosts; Aquatic insects; Disease transmission; Public health; pandemics; Serotypes; Dengue; Vectors; Infection; Dengue virus; Aedes; I, Pacific; ASW, Brazil DO - http://dx.doi.org/10.1155/2015/321873 ER - TY - JOUR T1 - Perspectives of Fijian Policymakers on the Obesity Prevention Policy Landscape AN - 1722168427; PQ0002026601 AB - In Fiji and other Pacific Island countries, obesity has rapidly increased in the past decade. Therefore, several obesity prevention policies have been developed. Studies show that their development has been hampered by factors within Fiji's policy landscape such as pressure from industry. Since policymakers in the Fijian national government are primarily responsible for the development of obesity policies, it is important to understand their perspectives; we therefore interviewed 15 policymakers from nine Fijian ministries. By applying the "attractor landscape" metaphor from dynamic systems theory, we captured perceived barriers and facilitators in the policy landscape. A poor economic situation, low food self-sufficiency, power inequalities, inappropriate framing of obesity, limited policy evidence, and limited resource sharing hamper obesity policy developments in Fiji. Facilitators include policy entrepreneurs and policy brokers who were active when a window of opportunity opened and who strengthened intersectoral collaboration. Fiji's policy landscape can become more conducive to obesity policies if power inequalities are reduced. In Fiji and other Pacific Island countries, this may be achievable through increased food self-sufficiency, strengthened intersectoral collaboration, and the establishment of an explicit functional focal unit within government to monitor and forecast the health impact of policy changes in non-health sectors. JF - BioMed Research International AU - Hendriks, Anna-Marie AU - Delai, Mere Y AU - Thow, Anne-Marie AU - Gubbels, Jessica S AU - De Vries, Nanne K AU - Kremers, Stef PJ AU - Jansen, Maria WJ AD - Academic Collaborative Centre for Public Health Limburg, Regional Public Health Service, P.O. Box 2022, 6160 HA Geleen, Netherlands, anna-marie.hendriks@maastrichtuniversity.nl Y1 - 2015/01// PY - 2015 DA - January 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - Obesity KW - Islands KW - Food KW - Landscape KW - Economics KW - Development KW - Pressure KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722168427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Perspectives+of+Fijian+Policymakers+on+the+Obesity+Prevention+Policy+Landscape&rft.au=Hendriks%2C+Anna-Marie%3BDelai%2C+Mere+Y%3BThow%2C+Anne-Marie%3BGubbels%2C+Jessica+S%3BDe+Vries%2C+Nanne+K%3BKremers%2C+Stef+PJ%3BJansen%2C+Maria+WJ&rft.aulast=Hendriks&rft.aufirst=Anna-Marie&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F926159 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Number of references - 1 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Obesity; Islands; Food; Economics; Landscape; Development; Pressure DO - http://dx.doi.org/10.1155/2015/926159 ER - TY - JOUR T1 - Construction of a gE-Deleted Pseudorabies Virus and Its Efficacy to the New-Emerging Variant PRV Challenge in the Form of Killed Vaccine AN - 1722168088; PQ0002030505 AB - The new-emerging PRV variants plague the vaccinated pigs and caused huge economic loss to local pig industry in China since 2011. The current commercial PRV vaccines cannot provide complete protection as the new-emerging PRV variants are antigenically different from the classical viruses. It is urgent to develop more safe and effective PRV vaccines based on the current circulating field isolates. In this study, a gE gene-deleted PRV based on the PRV HN1201, a representative PRV variant, was generated and the efficacy was tested on 3-week-old pigs in the form of killed vaccine. After fatal PRV HN1201 challenge, all vaccinated pigs survived without showing any clinical symptoms, but all unvaccinated pigs exhibited pseudorabies-specific respiratory and neurological signs with 100% mortality rate within 6 days after infection. The vaccinated pigs developed high level of gB and neutralizing antibodies after vaccination which may correlate to the protection provided by vaccine. Therefore, this gE gene-deleted PRV could be a promising vaccine candidate for the control of currently epidemic pseudorabies in China. JF - BioMed Research International AU - Wang, Tongyan AU - Xiao, Yan AU - Yang, Qingyuan AU - Wang, Yuzhou AU - Sun, Zhe AU - Zhang, Chaoling AU - Yan, Shijun AU - Wang, Juan AU - Guo, Linghua AU - Yan, He AU - Gao, Zhiyu AU - Wang, Lilin AU - Li, Xiangdong AU - Tan, Feifei AU - Tian, Kegong AD - National Research Center for Veterinary Medicine, Road Cuiwei, High-Tech District, Luoyang 471003, China, tf0801@126.com Y1 - 2015/01// PY - 2015 DA - January 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Pseudorabies virus KW - Pseudorabies KW - Mortality KW - Antibodies KW - Epidemics KW - Economics KW - Vaccines KW - Plague KW - Infection KW - V 22410:Animal Diseases KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722168088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Construction+of+a+gE-Deleted+Pseudorabies+Virus+and+Its+Efficacy+to+the+New-Emerging+Variant+PRV+Challenge+in+the+Form+of+Killed+Vaccine&rft.au=Wang%2C+Tongyan%3BXiao%2C+Yan%3BYang%2C+Qingyuan%3BWang%2C+Yuzhou%3BSun%2C+Zhe%3BZhang%2C+Chaoling%3BYan%2C+Shijun%3BWang%2C+Juan%3BGuo%2C+Linghua%3BYan%2C+He%3BGao%2C+Zhiyu%3BWang%2C+Lilin%3BLi%2C+Xiangdong%3BTan%2C+Feifei%3BTian%2C+Kegong&rft.aulast=Wang&rft.aufirst=Tongyan&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F684945 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Pseudorabies; Mortality; Antibodies; Epidemics; Economics; Plague; Vaccines; Infection; Pseudorabies virus DO - http://dx.doi.org/10.1155/2015/684945 ER - TY - JOUR T1 - Advances in mechanisms and signaling pathways of carbon nanotube toxicity AN - 1722165707; PQ0002058458 AB - Carbon nanotubes (CNT) have been developed into new materials with a variety of industrial and commercial applications. In contrast, the physicochemical properties of CNT at the nanoscale render them the potency to generate toxic effects. Indeed, the potential health impacts of CNT have drawn a great deal of attention in recent years, owing to their identified toxicological and pathological consequences including cytotoxicity, inflammation, fibrosis, genotoxicity, tumorigenesis, and immunotoxicity. Understanding the mechanisms by which CNT induce toxicity and pathology is thus urgently needed for accurate risk assessment of CNT exposure in humans, and for safe and responsible development and commercialization of nanotechnology. Here, we summarize and discuss recent advances in this area with a focus on the molecular interactions between CNT and mammalian systems, and the signaling pathways important for the development of CNT toxicity such as the NF- Kappa B, NLRP3 inflammasome, TGF- beta 1, MAPK, and p53 signaling cascades. With the current mechanistic evidence summarized in this review, we expect to provide new insights into CNT toxicology at the molecular level and offer new clues to the prevention of health effects resulting from CNT exposure. Moreover, we disclose questions and issues that remain in this rapidly advancing field of nanotoxicology, which would facilitate ascertaining future research directions. JF - Nanotoxicology AU - Dong, Jie AU - Ma, Oiang AD - Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 658 EP - 676 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 9 IS - 5 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - Risk assessment KW - Transforming growth factor- beta 1 KW - MAP kinase KW - Fibrosis KW - Tumorigenesis KW - Physicochemical properties KW - Genotoxicity KW - NF- Kappa B protein KW - Inflammation KW - p53 protein KW - Immunotoxicity KW - Cytotoxicity KW - Carbon KW - Reviews KW - nanotechnology KW - Signal transduction KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722165707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Advances+in+mechanisms+and+signaling+pathways+of+carbon+nanotube+toxicity&rft.au=Dong%2C+Jie%3BMa%2C+Oiang&rft.aulast=Dong&rft.aufirst=Jie&rft.date=2015-01-01&rft.volume=9&rft.issue=5&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2015.1009187 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Transforming growth factor- beta 1; Risk assessment; MAP kinase; Fibrosis; Genotoxicity; Physicochemical properties; Tumorigenesis; p53 protein; Inflammation; NF- Kappa B protein; Cytotoxicity; Immunotoxicity; Carbon; Reviews; Signal transduction; nanotechnology DO - http://dx.doi.org/10.3109/17435390.2015.1009187 ER - TY - JOUR T1 - Risk Factors for Leprosy Reactions in Three Endemic Countries AN - 1722164397; PQ0002059451 AB - The objective of this study was to ascertain risk factors for complications (reactions or neuritis) in leprosy patients at the time of diagnosis in three leprosy-endemic countries. Newly diagnosed patients were enrolled in Brazil, the Philippines, and Nepal, and risk factors for reactions and neuritis were assessed using a case-control approach: "cases" were patients with these complications, and controls were patients without complications. Of 1,972 patients enrolled in this study, 22% had complications before treatment. Type 1 reaction was diagnosed in 1 3.7% of patients, neuritis alone in 6.9.%, and type 2 reaction in 1.4%. The frequency of these complications was higher in Nepal, in lepromatous patients, in males, and in adults versus children. Reactions and neuritis were seen in patients at diagnosis, before treatment was started. Reactions were seen in adults and children, even in patients with only a single lesion. Neuritis was often present without other signs of reaction. Reactions and neuritis were more likely to occur in lepromatous patients, and were more likely to be seen in adults than in children. JF - American Journal of Tropical Medicine and Hygiene AU - Scollard, David M AU - Martelli, Celina M T AU - Stefani, Mariane M A AU - Maroja, Maria de Fatima AU - Villahermosa, Laarni AU - Pardillo, Fe AU - Tamang, Krishna B AD - National Flansen's Disease Programs, Baton Rouge, Louisiana, dscollard@hrsa.gov Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 108 EP - 114 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 92 IS - 1 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Endemic species KW - ISEW, Philippines KW - Risk factors KW - ASW, Brazil KW - Children KW - Hygiene KW - Nepal KW - Risks KW - Neuritis KW - Leprosy KW - K 03400:Human Diseases KW - Q1 08604:Stock assessment and management KW - Q5 08505:Prevention and control KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722164397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Risk+Factors+for+Leprosy+Reactions+in+Three+Endemic+Countries&rft.au=Scollard%2C+David+M%3BMartelli%2C+Celina+M+T%3BStefani%2C+Mariane+M+A%3BMaroja%2C+Maria+de+Fatima%3BVillahermosa%2C+Laarni%3BPardillo%2C+Fe%3BTamang%2C+Krishna+B&rft.aulast=Scollard&rft.aufirst=David&rft.date=2015-01-01&rft.volume=92&rft.issue=1&rft.spage=108&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.13-0221 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Endemic species; Hygiene; Risks; Risk factors; Children; Leprosy; Neuritis; ISEW, Philippines; ASW, Brazil; Nepal DO - http://dx.doi.org/10.4269/ajtmh.13-0221 ER - TY - JOUR T1 - Detecting Lung Diseases from Exhaled Aerosols: Non-Invasive Lung Diagnosis Using Fractal Analysis and SVM Classification. AN - 1718910407; 26422016 AB - Each lung structure exhales a unique pattern of aerosols, which can be used to detect and monitor lung diseases non-invasively. The challenges are accurately interpreting the exhaled aerosol fingerprints and quantitatively correlating them to the lung diseases. In this study, we presented a paradigm of an exhaled aerosol test that addresses the above two challenges and is promising to detect the site and severity of lung diseases. This paradigm consists of two steps: image feature extraction using sub-regional fractal analysis and data classification using a support vector machine (SVM). Numerical experiments were conducted to evaluate the feasibility of the breath test in four asthmatic lung models. A high-fidelity image-CFD approach was employed to compute the exhaled aerosol patterns under different disease conditions. By employing the 10-fold cross-validation method, we achieved 100% classification accuracy among four asthmatic models using an ideal 108-sample dataset and 99.1% accuracy using a more realistic 324-sample dataset. The fractal-SVM classifier has been shown to be robust, highly sensitive to structural variations, and inherently suitable for investigating aerosol-disease correlations. For the first time, this study quantitatively linked the exhaled aerosol patterns with their underlying diseases and set the stage for the development of a computer-aided diagnostic system for non-invasive detection of obstructive respiratory diseases. JF - PloS one AU - Xi, Jinxiang AU - Zhao, Weizhong AU - Yuan, Jiayao Eddie AU - Kim, JongWon AU - Si, Xiuhua AU - Xu, Xiaowei AD - School of Engineering and Technology, Central Michigan University, Mount Pleasant, Michigan, United States of America. ; College of Information Engineering, Xiangtan University, Xiangtan, Hunan Province, China; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, Jefferson, Arkansas, United States of America. ; College of Engineering, University of Georgia, Athens, Georgia, United States of America. ; Department of Mechanical Engineering, California Baptist University, Riverside, California, United States of America. ; Department of Information Science, University of Arkansas, Little Rock, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 9 KW - Aerosols KW - 0 KW - Index Medicus KW - Humans KW - Prognosis KW - Breath Tests KW - Aerosols -- classification KW - Lung Diseases -- diagnosis KW - Support Vector Machine KW - Asthma -- diagnosis KW - Aerosols -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1718910407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Detecting+Lung+Diseases+from+Exhaled+Aerosols%3A+Non-Invasive+Lung+Diagnosis+Using+Fractal+Analysis+and+SVM+Classification.&rft.au=Xi%2C+Jinxiang%3BZhao%2C+Weizhong%3BYuan%2C+Jiayao+Eddie%3BKim%2C+JongWon%3BSi%2C+Xiuhua%3BXu%2C+Xiaowei&rft.aulast=Xi&rft.aufirst=Jinxiang&rft.date=2015-01-01&rft.volume=10&rft.issue=9&rft.spage=e0139511&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0139511 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-19 N1 - Date created - 2015-10-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Biol Res. 2000;33(1):31-5 [11021308] Am J Respir Crit Care Med. 2001 Sep 1;164(5):731-7 [11549524] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15149-54 [11742071] Biosens Bioelectron. 2003 Sep;18(10):1209-18 [12835038] Chest. 2003 Oct;124(4):1373-80 [14555568] Nature. 2004 Feb 12;427(6975):633-6 [14961120] Clin Chim Acta. 2004 Sep;347(1-2):25-39 [15313139] Nature. 1967 Feb 18;213(5077):668-9 [6031769] J Appl Physiol (1985). 1990 Feb;68(2):457-61 [2318756] J Aerosol Med. 1994;7(1):77-88 [10147059] J Aerosol Med. 1996 Summer;9(2):183-205 [10163350] J Pathol. 1998 Aug;185(4):366-81 [9828835] Science. 1962 Aug 24;137(3530):577-85 [14005590] Am J Respir Crit Care Med. 2005 Oct 1;172(7):817-23 [15976372] Nat Biotechnol. 2006 Dec;24(12):1565-7 [17160063] Ann Biomed Eng. 2007 Apr;35(4):560-81 [17237991] IEEE Trans Med Imaging. 2007 Oct;26(10):1366-78 [17948727] Clin Exp Allergy. 2008 Apr;38(4):557-65 [18352973] J Appl Physiol (1985). 2008 Jun;104(6):1761-77 [18388247] Ann Biomed Eng. 2008 Oct;36(10):1714-34 [18712605] Lung Cancer. 2009 Feb;63(2):164-8 [18599152] J Thorac Oncol. 2009 Feb;4(2):172-8 [19179892] Curr Drug Targets. 2011 Apr;12(4):469-77 [21194408] Int J Numer Method Biomed Eng. 2013 Jan;29(1):17-39 [23293067] Respir Physiol Neurobiol. 2013 Mar 1;186(1):22-32 [23313127] Inhal Toxicol. 2014 Jul;26(8):492-505 [24987981] PLoS One. 2014;9(8):e104682 [25105680] Theranostics. 2015;5(5):443-55 [25767612] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0139511 ER - TY - JOUR T1 - Toxicogenomic responses of human liver HepG2 cells to silver nanoparticles AN - 1709168607; PQ0001901487 AB - The increased use of silver nanoparticles (AgNPs) in foods and cosmetics has raised public safety concerns. However, only limited knowledge exists on the effect of AgNPs on the cellular transcriptome. This study evaluated global gene expression profiles of human liver HepG2 cells exposed to 20 and 50nm AgNPs for 4 and 24h at 2.5 mu gml super(-1). Exposure to 20nm AgNPs resulted in 811 altered genes after 4h, but much less after 24h. Exposure to 50nm AgNPs showed minimal altered genes at both exposure times. The HepG2 cells responded to the toxic insult of AgNPs by transiently upregulating stress response genes such as metallothioneins and heat shock proteins. Functional analysis of the altered genes showed more than 20 major biological processes were affected, of which metabolism, development, cell differentiation and cell death were the most dominant categories. Several cellular pathways were also impacted by AgNP exposure, including the p53 signaling pathway and the NRF2-mediated oxidative stress response pathway, which may lead to increased oxidative stress and DNA damage in the cell and potentially result in genotoxicity and carcinogenicity. Together, these results indicate that HepG2 cells underwent a multitude of cellular processes in response to the toxic insult of AgNP exposure, and suggest that toxicogenomic characterization of human HepG2 cells could serve as an alternative model for assessing toxicities of NPs. This study evaluated global gene expression profiles of human liver HepG2 cells exposed to silver nanoparticles (AgNPs). Exposure to 2.5 mu gml super(-1) 20nm AgNPs resulted in 811 altered genes after 4h. Function and pathway analysis of the altered genes suggest that AgNP exposure may lead to increased oxidative stress and DNA damage in the cell and potentially result in genotoxicity and carcinogenicity. JF - Journal of Applied Toxicology AU - Sahu, Saura C AU - Zheng, Jiwen AU - Yourick, Jeffrey J AU - Sprando, Robert L AU - Gao, Xiugong AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Laurel, MD, USA. PY - 2015 SP - 1160 EP - 1168 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 35 IS - 10 SN - 0260-437X, 0260-437X KW - Toxicology Abstracts KW - Heat shock proteins KW - Metallothionein KW - Hepatocytes KW - Food KW - Genotoxicity KW - Cosmetics KW - p53 protein KW - Gene expression KW - DNA damage KW - Differentiation KW - Cell death KW - Carcinogenicity KW - Oxidative stress KW - Silver KW - nanoparticles KW - Metabolism KW - Signal transduction KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709168607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Toxicogenomic+responses+of+human+liver+HepG2+cells+to+silver+nanoparticles&rft.au=Sahu%2C+Saura+C%3BZheng%2C+Jiwen%3BYourick%2C+Jeffrey+J%3BSprando%2C+Robert+L%3BGao%2C+Xiugong&rft.aulast=Sahu&rft.aufirst=Saura&rft.date=2015-01-01&rft.volume=35&rft.issue=10&rft.spage=1160&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.3170 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Heat shock proteins; Metallothionein; Hepatocytes; Food; Genotoxicity; Cosmetics; p53 protein; Gene expression; Differentiation; DNA damage; Cell death; Oxidative stress; Carcinogenicity; nanoparticles; Silver; Metabolism; Signal transduction DO - http://dx.doi.org/10.1002/jat.3170 ER - TY - JOUR T1 - Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. AN - 1699492865; 26208104 AB - Metabolomics approaches have enabled the study of new mechanisms of liver injury in experimental models of drug toxicity. Disruption of bile acid homeostasis is a known mechanism of drug induced liver injury. The relationship of individual bile acids to indicators of oxidative drug metabolism (acetaminophen protein adducts) and liver injury was examined in children with acetaminophen overdose, hospitalized children with low dose exposure to acetaminophen, and children with no recent exposure to acetaminophen. Nine bile acids were quantified through targeted metabolomic analysis in the serum samples of the three groups. Bile acids were compared to serum levels of acetaminophen protein adducts and alanine aminotransferase. Glycodeoxycholic acid, taurodeoxycholic acid, and glycochenodeoxycholic acid were significantly increased in children with acetaminophen overdose compared to healthy controls. Among patients with acetaminophen overdose, bile acids were higher in subjects with acetaminophen protein adduct values > 1.0 nmol/mL and modest correlations were noted for three bile acids and acetaminophen protein adducts as follows: taurodeoxycholic acid (R=0.604; p<0.001), glycodeoxycholic acid (R=0.581; p<0.001), and glycochenodeoxycholic acid (R=0.571; p<0.001). Variability in bile acids was greater among hospitalized children receiving low doses of acetaminophen than in healthy children with no recent acetaminophen exposure. Compared to bile acids, acetaminophen protein adducts more accurately discriminated among children with acetaminophen overdose, children with low dose exposure to acetaminophen, and healthy control subjects. In children with acetaminophen overdose, elevations of conjugated bile acids were associated with specific indicators of acetaminophen metabolism and non-specific indicators of liver injury. JF - PloS one AU - James, Laura AU - Yan, Ke AU - Pence, Lisa AU - Simpson, Pippa AU - Bhattacharyya, Sudeepa AU - Gill, Pritmohinder AU - Letzig, Lynda AU - Kearns, Gregory AU - Beger, Richard AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, United States of America; Arkansas Children's Hospital Research Institute, Little Rock, AR 72202, United States of America. ; Medical College of Wisconsin, Milwaukee, WI 53226, United States of America. ; Division of Systems Biology, National Center for Toxicological Research, Jefferson, AR 72079, United States of America. ; Division of Pediatric Pharmacology, Medical Toxicology and Therapeutic Innovation, The Children's Mercy Hospital, Kansas City, MO 64108, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 7 KW - Bile Acids and Salts KW - 0 KW - Biomarkers KW - Glycodeoxycholic Acid KW - 360-65-6 KW - Acetaminophen KW - 362O9ITL9D KW - Taurodeoxycholic Acid KW - 516-50-7 KW - Glycochenodeoxycholic Acid KW - 640-79-9 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Sensitivity and Specificity KW - Taurodeoxycholic Acid -- blood KW - Metabolomics -- methods KW - Diagnosis, Differential KW - Alanine Transaminase -- metabolism KW - Humans KW - Glycochenodeoxycholic Acid -- blood KW - Child KW - Glycodeoxycholic Acid -- blood KW - Homeostasis KW - Protein Binding KW - Child, Preschool KW - Adolescent KW - Biomarkers -- blood KW - Female KW - Male KW - Chemical and Drug Induced Liver Injury -- blood KW - Bile Acids and Salts -- blood KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Acetaminophen -- poisoning KW - Acetaminophen -- metabolism KW - Drug Overdose -- diagnosis KW - Drug Overdose -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1699492865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Comparison+of+Bile+Acids+and+Acetaminophen+Protein+Adducts+in+Children+and+Adolescents+with+Acetaminophen+Toxicity.&rft.au=James%2C+Laura%3BYan%2C+Ke%3BPence%2C+Lisa%3BSimpson%2C+Pippa%3BBhattacharyya%2C+Sudeepa%3BGill%2C+Pritmohinder%3BLetzig%2C+Lynda%3BKearns%2C+Gregory%3BBeger%2C+Richard&rft.aulast=James&rft.aufirst=Laura&rft.date=2015-01-01&rft.volume=10&rft.issue=7&rft.spage=e0131010&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0131010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-02 N1 - Date created - 2015-07-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Arch Surg. 1996 Dec;131(12):1280-7; discussion 1287-8 [8956769] Toxicol Sci. 2014 Jan;137(1):12-25 [24085190] Arch Pediatr Adolesc Med. 2000 Apr;154(4):346-50 [10768670] Am J Physiol Gastrointest Liver Physiol. 2001 Jun;280(6):G1274-9 [11352821] Drug Metab Dispos. 2002 Apr;30(4):446-51 [11901099] Gut. 2002 Jul;51(1):113-9 [12077103] Toxicol Sci. 2003 Nov;76(1):220-8 [12944587] Drug Metab Dispos. 2003 Dec;31(12):1499-506 [14625346] Hepatology. 2004 Nov;40(5):1170-9 [15486922] J Pharmacol Exp Ther. 1973 Oct;187(1):185-94 [4746326] Pediatrics. 1975 Jun;55(6):871-6 [1134886] Lancet. 1975 Sep 27;2(7935):579-81 [51407] Pediatr Clin North Am. 1986 Jun;33(3):691-701 [3714342] N Engl J Med. 1988 Dec 15;319(24):1557-62 [3059186] Biochem Pharmacol. 1990 Aug 1;40(3):573-9 [2200409] Am J Pathol. 1991 Feb;138(2):359-71 [1992763] Hepatology. 1998 Mar;27(3):748-54 [9500703] Hepatology. 2005 Dec;42(6):1364-72 [16317692] Gastroenterology. 2006 Mar;130(3):687-94 [16530510] Nature. 2006 Apr 20;440(7087):1073-7 [16625200] Pharmacogenomics. 2006 Oct;7(7):1077-86 [17054417] Toxicol Appl Pharmacol. 2008 Jan 1;226(1):74-83 [17935745] J Biol Chem. 2008 May 16;283(20):13565-77 [18337250] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 15;871(2):328-40 [18472313] Clin Pharmacol Ther. 2008 Dec;84(6):684-90 [18923390] Chem Res Toxicol. 2009 Apr;22(4):699-707 [19256530] Toxicol Sci. 2014 Dec;142(2):436-44 [25239633] Drug Metab Dispos. 2009 Aug;37(8):1779-84 [19439490] Ann Emerg Med. 2009 Sep;54(3):421-3 [18986731] Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14728-33 [19667173] Toxicology. 2010 Feb 28;269(1):24-34 [20067817] Hepatology. 2011 Feb;53(2):567-76 [21274877] Toxicol Appl Pharmacol. 2011 May 1;252(3):211-20 [21316383] Electrophoresis. 2011 Aug;32(15):2063-70 [21732555] Toxicol Appl Pharmacol. 2013 Apr 1;268(1):79-89 [23360887] Toxicol Appl Pharmacol. 2013 Apr 15;268(2):132-40 [23391614] Eur J Clin Pharmacol. 2013 Apr;69(4):851-7 [23052410] Compr Physiol. 2013 Jul;3(3):1191-212 [23897684] Am J Pathol. 2013 Nov;183(5):1518-26 [24007882] Biomark Med. 2014;8(2):147-59 [24521011] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0131010 ER - TY - JOUR T1 - Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood. AN - 1697755641; 26177368 AB - Methods were developed to evaluate the stability of rat whole blood expression obtained from RNA sequencing (RNA-seq) and assess changes in whole blood transcriptome profiles in experiments replicated over time. Expression was measured in globin-depleted RNA extracted from the whole blood of Sprague-Dawley rats, given either saline (control) or neurotoxic doses of amphetamine (AMPH). The experiment was repeated four times (paired control and AMPH groups) over a 2-year span. The transcriptome of the control and AMPH-treated groups was evaluated on: 1) transcript levels for ribosomal protein subunits; 2) relative expression of immune-related genes; 3) stability of the control transcriptome over 2 years; and 4) stability of the effects of AMPH on immune-related genes over 2 years. All, except one, of the 70 genes that encode the 80s ribosome had levels that ranked in the top 5% of all mean expression levels. Deviations in sequencing performance led to significant changes in the ribosomal transcripts. The overall expression profile of immune-related genes and genes specific to monocytes, T-cells or B-cells were well represented and consistent within treatment groups. There were no differences between the levels of ribosomal transcripts in time-matched control and AMPH groups but significant differences in the expression of immune-related genes between control and AMPH groups. AMPH significantly increased expression of some genes related to monocytes but down-regulated those specific to T-cells. These changes were partially due to changes in the two types of leukocytes present in blood, which indicate an activation of the innate immune system by AMPH. Thus, the stability of RNA-seq whole blood transcriptome can be verified by assessing ribosomal protein subunits and immune-related gene expression. Such stability enables the pooling of samples from replicate experiments to carry out differential expression analysis with acceptable power. JF - PloS one AU - Bowyer, John F AU - Tranter, Karen M AU - Hanig, Joseph P AU - Crabtree, Nathaniel M AU - Schleimer, Robert P AU - George, Nysia I AD - Division of Neurotoxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America. ; Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, United States of America. ; Division of Allergy and Immunology, Northwestern Feinberg School of Medicine, Chicago, Illinois, United States of America. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 7 KW - RNA, Messenger KW - 0 KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Ribosome Subunits -- genetics KW - Leukocytes -- metabolism KW - Animals KW - Rats, Sprague-Dawley KW - RNA, Messenger -- metabolism KW - Ribosome Subunits -- metabolism KW - Gene Expression Regulation -- drug effects KW - RNA, Messenger -- genetics KW - Male KW - Leukocytes -- drug effects KW - Gene Expression Profiling KW - Transcriptome -- genetics KW - RNA Stability -- drug effects KW - Sequence Analysis, RNA KW - RNA Stability -- genetics KW - Blood -- metabolism KW - Blood -- drug effects KW - Immunity -- drug effects KW - Amphetamine -- pharmacology KW - Transcriptome -- drug effects KW - Immunity -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1697755641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Evaluating+the+Stability+of+RNA-Seq+Transcriptome+Profiles+and+Drug-Induced+Immune-Related+Expression+Changes+in+Whole+Blood.&rft.au=Bowyer%2C+John+F%3BTranter%2C+Karen+M%3BHanig%2C+Joseph+P%3BCrabtree%2C+Nathaniel+M%3BSchleimer%2C+Robert+P%3BGeorge%2C+Nysia+I&rft.aulast=Bowyer&rft.aufirst=John&rft.date=2015-01-01&rft.volume=10&rft.issue=7&rft.spage=e0133315&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0133315 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-05-03 N1 - Date created - 2015-07-16 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - GSE62368; GEO; GSE64778 N1 - SuppNotes - Cited By: Cell Immunol. 2014 Sep-Oct;291(1-2):32-40 [25205002] BMC Genomics. 2013;14:147 [23497014] BMC Med Genomics. 2013;6:26 [23883607] Diabetes Obes Metab. 2013 Sep;15 Suppl 3:10-8 [24003916] Int J Oncol. 2013 Nov;43(5):1343-50 [23969601] Psychiatry Res. 2013 Nov 30;210(1):287-93 [23778302] PLoS One. 2015;10(6):e0125224 [26039068] Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15448-53 [17873064] Annu Rev Immunol. 2001;19:197-223 [11244035] Blood. 2001 Apr 15;97(8):2457-68 [11290611] Immunity. 2001 Jun;14(6):779-90 [11420047] Immunol Rev. 2001 Jun;181:234-49 [11513145] Genome Biol. 2002 Jun 18;3(7):RESEARCH0034 [12184808] Neurotoxicology. 2002 Sep;23(3):397-414 [12387366] Nat Rev Immunol. 2002 Dec;2(12):909-19 [12461564] Immunity. 2003 Jul;19(1):71-82 [12871640] Immunol Rev. 1987 Dec;100:225-60 [3326822] FASEB J. 1988 Jul;2(10):2584-90 [2838364] Science. 1989 Jan 20;243(4889):398-400 [2563176] Immunol Rev. 1989 Oct;111:145-75 [2697680] J Immunol. 1995 Apr 1;154(7):3333-40 [7897216] FASEB J. 1995 Jul;9(10):866-73 [7542213] Science. 1995 Sep 15;269(5230):1583-5 [7667639] Genes Immun. 2005 Jun;6(4):279-84 [15815687] Mol Diagn Ther. 2006;10(4):257-69 [16884330] Biotechniques. 2007 Apr;42(4):503-12 [17489238] Biochem J. 2000 Mar 15;346 Pt 3:729-36 [10698700] Brain Behav Immun. 2007 Aug;21(6):736-45 [17467231] Trends Mol Med. 2007 Oct;13(10):422-32 [17919976] Genome Res. 2008 Sep;18(9):1509-17 [18550803] Ann N Y Acad Sci. 2008 Oct;1139:127-39 [18991857] PLoS One. 2014;9(1):e78644 [24454679] Genome Biol. 2014;15(12):550 [25516281] PLoS One. 2015;10(5):e0125045 [25946140] PLoS One. 2009;4(8):e6484 [19649296] J Exp Biol. 2010 Aug 15;213(Pt 16):2734-40 [20675542] Nat Immunol. 2010 Oct;11(10):889-96 [20856220] J Immunol. 2011 Mar 1;186(5):3047-57 [21307297] J Biotechnol. 2011 Feb 20;151(4):325-34 [21219943] Blood. 2011 Aug 18;118(7):1774-83 [21659548] BMC Bioinformatics. 2011;12:323 [21816040] BMC Genomics. 2012;13:28 [22257641] J Asthma. 2012 Apr;49(3):219-26 [22316092] Annu Rev Immunol. 2012;30:459-89 [22224774] BMC Genomics. 2012;13:250 [22708644] BMC Med Genomics. 2012;5:28 [22747986] J Clin Rheumatol. 2012 Dec;18(8):443-9 [23211587] Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21028-33 [23213261] Brain Behav Immun. 2013 Feb;28:159-69 [23201588] Blood. 2013 Mar 14;121(11):1951-60 [23293083] Cerebrovasc Dis. 2014;37(1):64-75 [24401164] Nat Biotechnol. 2014 Feb;32(2):111-2 [24509734] Biomark Med. 2014;8(2):297-306 [24521026] Int J Mol Med. 2014 Apr;33(4):777-83 [24535646] Dig Dis. 2014;32(1-2):102-6 [24603390] PLoS One. 2014;9(3):e91041 [24608128] Clin Rev Allergy Immunol. 2014 Apr;46(2):154-68 [24569953] BMC Bioinformatics. 2014;15:92 [24685233] Auton Neurosci. 2014 May;182:15-41 [24685093] Annu Rev Biochem. 2014;83:467-86 [24580643] Circ Res. 2014 Jun 20;115(1):165-75 [24951765] Immunol Rev. 2014 Sep;261(1):169-76 [25123284] Nat Biotechnol. 2014 Sep;32(9):915-25 [25150835] J Asthma. 2014 Oct;51(8):847-54 [24796647] Exp Cell Res. 2014 Dec 10;329(2):248-54 [25149680] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0133315 ER - TY - JOUR T1 - Rural Affordable Care Act Outreach and Enrollment: What We Learned During the First Marketplace Open Enrollment Period AN - 1695970946 AB - As part of the Patient Protection and Affordable Care Act (Affordable Care Act) of 2010, 2 new opportunities for health care coverage were established for many uninsured individuals beginning on January 1, 2014. The first opportunity was through Medicaid expansion where states had the opportunity to expand Medicaid coverage to individuals with household incomes up to 133% of the federal poverty level. The second opportunity was through the establishment of Health Insurance Marketplaces where individuals could purchase private health plans and potentially qualify for financial assistance in paying for their plans. The Office of Rural Health Policy (ORHP) provided supplemental grant awards to help stimulate Affordable Care Act outreach and education efforts in rural communities that were being served by the Rural Health Care Services Outreach (Outreach) Grant Program. As a result, Outreach grantees enrolled 9,300 rural Americans during the initial Open Enrollment period. Valuable outreach and enrollment lessons were learned from rural communities based on discussions with the Outreach grantees who received the supplemental funding. These lessons will help rural communities prepare for the next Open Enrollment period. JF - The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association AU - Kwon, Linda AD - Health Resources and Services Administration, Office of Rural Health Policy, Rockville, Maryland. ; Health Resources and Services Administration, Office of Rural Health Policy, Rockville, Maryland. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 1 EP - 3 CY - Washington PB - Wiley Subscription Services, Inc. VL - 31 IS - 1 SN - 0890-765X KW - Public Health And Safety KW - Coverage KW - Health Care Industry KW - Awards KW - Services KW - Poverty KW - Enrollment KW - Rural Communities KW - Health Care Services Policy KW - Health Insurance KW - Medicaid KW - Patients KW - Rural Areas KW - Rural Education KW - Uninsured Persons KW - Rural communities KW - Uninsured patients KW - Financing KW - Health care KW - Health insurance KW - Health policy KW - Insurance KW - Outreach programmes KW - Patient care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1695970946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.atitle=Rural+Affordable+Care+Act+Outreach+and+Enrollment%3A+What+We+Learned+During+the+First+Marketplace+Open+Enrollment+Period&rft.au=Kwon%2C+Linda&rft.aulast=Kwon&rft.aufirst=Linda&rft.date=2015-01-01&rft.volume=31&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health+%3A+Official+Journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fjrh.12100 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); PAIS Index N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-06-28 DO - http://dx.doi.org/10.1111/jrh.12100 ER - TY - JOUR T1 - Antivibration Gloves: Effects on Vascular and Sensorineural Function, an Animal Model AN - 1691297042; PQ0001611320 AB - Anti-vibration gloves have been used to block the transmission of vibration from powered hand tools to the user, and to protect users from the negative health consequences associated with exposure to vibration. However, there are conflicting reports as to the efficacy of gloves in protecting workers. The goal of this study was to use a characterized animal model of vibration-induced peripheral vascular and nerve injury to determine whether antivibration materials reduced or inhibited the effects of vibration on these physiological symptoms. Rats were exposed to 4 h of tail vibration at 125 Hz with an acceleration 49 m/s super(2). The platform was either bare or covered with antivibrating glove material. Rats were tested for tactile sensitivity to applied pressure before and after vibration exposure. One day following the exposure, ventral tail arteries were assessed for sensitivity to vasodilating and vasoconstricting factors and nerves were examined histologically for early indicators of edema and inflammation. Ventral tail artery responses to an alpha 2C-adrenoreceptor agonist were enhanced in arteries from vibration-exposed rats compared to controls, regardless of whether antivibration materials were used or not. Rats exposed to vibration were also less sensitive to pressure after exposure. These findings are consistent with experimental findings in humans suggesting that antivibration gloves may not provide protection against the adverse health consequences of vibration exposure in all conditions. Additional studies need to be done examining newer antivibration materials. JF - Journal of Toxicology and Environmental Health, Part A: Current Issues AU - Krajnak, K AU - Waugh, S AU - Johnson, C AU - Miller, R G AU - Welcome, D AU - Xu, X AU - Warren, C AU - Sarkisian, S AU - Andrew, M AU - Dong, R G AD - Engineering and Controls Technology Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2015///0, PY - 2015 DA - 0, 2015 SP - 571 EP - 582 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 78 IS - 9 SN - 1528-7394, 1528-7394 KW - Toxicology Abstracts KW - alpha 2C-Adrenergic receptors KW - Injuries KW - Tails KW - Arteries KW - Animal models KW - Edema KW - Hand KW - Inflammation KW - Nerves KW - Vibrations KW - Workers KW - Gloves KW - Pressure KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691297042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.atitle=Antivibration+Gloves%3A+Effects+on+Vascular+and+Sensorineural+Function%2C+an+Animal+Model&rft.au=Krajnak%2C+K%3BWaugh%2C+S%3BJohnson%2C+C%3BMiller%2C+R+G%3BWelcome%2C+D%3BXu%2C+X%3BWarren%2C+C%3BSarkisian%2C+S%3BAndrew%2C+M%3BDong%2C+R+G&rft.aulast=Krajnak&rft.aufirst=K&rft.date=2015-01-01&rft.volume=78&rft.issue=9&rft.spage=571&rft.isbn=&rft.btitle=&rft.title=Journal+of+Toxicology+and+Environmental+Health%2C+Part+A%3A+Current+Issues&rft.issn=15287394&rft_id=info:doi/10.1080%2F15287394.2015.1014079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - alpha 2C-Adrenergic receptors; Injuries; Tails; Arteries; Animal models; Hand; Edema; Inflammation; Vibrations; Nerves; Workers; Gloves; Pressure DO - http://dx.doi.org/10.1080/15287394.2015.1014079 ER - TY - JOUR T1 - Evaluation of Diffuse Reflection Infrared Spectrometry for End-of-Shift Measurement of α-quartz in Coal Dust Samples. AN - 1691284326; 25636081 AB - The inhalation of toxic substances is a major threat to the health of miners, and dust containing respirable crystalline silica (α-quartz) is of particular concern, due to the recent rise in cases of coal workers' pneumoconiosis and silicosis in some U.S. mining regions. Currently, there is no field-portable instrument that can measure airborne α-quartz and give miners timely feedback on their exposure. The U.S. National Institute for Occupational Safety and Health (NIOSH) is therefore conducting studies to investigate technologies capable of end-of-shift or real-time measurement of airborne quartz. The present study focuses on the potential application of Fourier transform infrared (FT-IR) spectrometry conducted in the diffuse reflection (DR) mode as a technique for measuring α-quartz in respirable mine dust. A DR accessory was used to analyze lab-generated respirable samples of Min-U-Sil 5 (which contains more than 90% α-quartz) and coal dust, at mass loadings in the ranges of 100-600 μg and 600-5300 μg, respectively. The dust samples were deposited onto three different types of filters, borosilicate fiberglass, nylon, and polyvinyl chloride (PVC). The reflectance, R, was calculated by the ratio of a blank filter and a filter with deposited mine dust. Results suggest that for coal and pure quartz dusts deposited on 37 mm PVC filters, measurements of -log R correlate linearly with known amounts of quartz on filters, with R(2) values of approximately 0.99 and 0.94, respectively, for samples loaded up to ∼4000 μg. Additional tests were conducted to measure quartz in coal dusts deposited onto the borosilicate fiberglass and nylon filter media used in the NIOSH-developed Personal Dust Monitor (PDM). The nylon filter was shown to be amenable to DR analysis, but quantification of quartz is more accurate when the filter is "free," as opposed to being mounted in the PDM filter holder. The borosilicate fiberglass filters were shown to produce excessive interference, making quartz quantification impossible. It was concluded that, while the DR/FT-IR method is potentially useful for on-filter measurement of quartz in dust samples, the use of PVC filters produced the most accurate results. JF - Journal of occupational and environmental hygiene AU - Miller, Arthur L AU - Murphy, Nathaniel C AU - Bayman, Sean J AU - Briggs, Zachary P AU - Kilpatrick, Andrew D AU - Quinn, Courtney A AU - Wadas, Mackenzie R AU - Cauda, Emanuele G AU - Griffiths, Peter R AD - a Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health , Spokane , Washington. Y1 - 2015 PY - 2015 DA - 2015 SP - 421 EP - 430 VL - 12 IS - 7 KW - Air Pollutants, Occupational KW - 0 KW - Coal KW - Dust KW - Quartz KW - 14808-60-7 KW - Index Medicus KW - α-quartz KW - silica KW - coal dust KW - diffuse reflection spectrometry KW - United States KW - Air Filters KW - Coal Mining KW - National Institute for Occupational Safety and Health (U.S.) KW - Occupational Exposure -- analysis KW - Spectroscopy, Fourier Transform Infrared -- methods KW - Dust -- analysis KW - Air Pollutants, Occupational -- analysis KW - Quartz -- analysis KW - Coal -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1691284326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=Evaluation+of+Diffuse+Reflection+Infrared+Spectrometry+for+End-of-Shift+Measurement+of+%CE%B1-quartz+in+Coal+Dust+Samples.&rft.au=Miller%2C+Arthur+L%3BMurphy%2C+Nathaniel+C%3BBayman%2C+Sean+J%3BBriggs%2C+Zachary+P%3BKilpatrick%2C+Andrew+D%3BQuinn%2C+Courtney+A%3BWadas%2C+Mackenzie+R%3BCauda%2C+Emanuele+G%3BGriffiths%2C+Peter+R&rft.aulast=Miller&rft.aufirst=Arthur&rft.date=2015-01-01&rft.volume=12&rft.issue=7&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2015.1011328 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-25 N1 - Date created - 2015-06-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Occup Environ Med. 2005 Oct;62(10):670-4 [16169911] J Environ Monit. 2008 Jan;10(1):96-101 [18175022] J Environ Monit. 2008 May;10(5):671-8 [18449405] Am J Ind Med. 2008 Sep;51(9):633-9 [18626906] Ann Occup Hyg. 2009 Aug;53(6):639-49 [19531809] Ann Occup Hyg. 2010 Aug;54(6):697-709 [20660144] Appl Spectrosc. 2011 Mar;65(3):243-9 [21352643] Occup Environ Med. 2011 Dec;68(12):908-13 [21597107] J Environ Monit. 2012 Jan;14(1):48-55 [22130611] Anal Bioanal Chem. 2014 Jul;406(19):4715-24 [24830397] Am J Ind Med. 2003 Aug;44(2):141-7 [12874846] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2015.1011328 ER - TY - JOUR T1 - An Iterative Leave-One-Out Approach to Outlier Detection in RNA-Seq Data. AN - 1686413656; 26039068 AB - The discrete data structure and large sequencing depth of RNA sequencing (RNA-seq) experiments can often generate outlier read counts in one or more RNA samples within a homogeneous group. Thus, how to identify and manage outlier observations in RNA-seq data is an emerging topic of interest. One of the main objectives in these research efforts is to develop statistical methodology that effectively balances the impact of outlier observations and achieves maximal power for statistical testing. To reach that goal, strengthening the accuracy of outlier detection is an important precursor. Current outlier detection algorithms for RNA-seq data are executed within a testing framework and may be sensitive to sparse data and heavy-tailed distributions. Therefore, we propose a univariate algorithm that utilizes a probabilistic approach to measure the deviation between an observation and the distribution generating the remaining data and implement it within in an iterative leave-one-out design strategy. Analyses of real and simulated RNA-seq data show that the proposed methodology has higher outlier detection rates for both non-normalized and normalized negative binomial distributed data. JF - PloS one AU - George, Nysia I AU - Bowyer, John F AU - Crabtree, Nathaniel M AU - Chang, Ching-Wei AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, FDA, Jefferson, Arkansas, United States of America. ; Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas, United States of America. ; Joint Bioinformatics Graduate Program, University of Arkansas at Little Rock and University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 6 KW - RNA KW - 63231-63-0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Sequence Analysis, DNA -- methods KW - Databases, Nucleic Acid KW - DNA -- genetics KW - Sequence Analysis, RNA -- methods KW - RNA -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686413656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=An+Iterative+Leave-One-Out+Approach+to+Outlier+Detection+in+RNA-Seq+Data.&rft.au=George%2C+Nysia+I%3BBowyer%2C+John+F%3BCrabtree%2C+Nathaniel+M%3BChang%2C+Ching-Wei&rft.aulast=George&rft.aufirst=Nysia&rft.date=2015-01-01&rft.volume=10&rft.issue=6&rft.spage=e0125224&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0125224 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-02-22 N1 - Date created - 2015-06-04 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Brief Bioinform. 2013 Nov;14(6):671-83 [22988256] PLoS One. 2013;8(12):e81415 [24349066] Nucleic Acids Res. 2014 Jun;42(11):e91 [24753412] Genome Biol. 2014;15(12):550 [25516281] Genome Res. 2008 Sep;18(9):1509-17 [18550803] Nature. 2008 Nov 27;456(7221):470-6 [18978772] Bioinformatics. 2010 Jan 1;26(1):139-40 [19910308] Genome Biol. 2010;11(3):R25 [20196867] BMC Bioinformatics. 2010;11:422 [20698981] Genome Biol. 2010;11(10):R106 [20979621] BMC Bioinformatics. 2011;12:449 [22087737] Biostatistics. 2013 Apr;14(2):232-43 [23001152] BMC Bioinformatics. 2013;14:91 [23497356] Stat Methods Med Res. 2013 Oct;22(5):519-36 [22127579] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0125224 ER - TY - JOUR T1 - Terminated Trials in the ClinicalTrials.gov Results Database: Evaluation of Availability of Primary Outcome Data and Reasons for Termination. AN - 1683759730; 26011295 AB - Clinical trials that end prematurely (or "terminate") raise financial, ethical, and scientific concerns. The extent to which the results of such trials are disseminated and the reasons for termination have not been well characterized. A cross-sectional, descriptive study of terminated clinical trials posted on the ClinicalTrials.gov results database as of February 2013 was conducted. The main outcomes were to characterize the availability of primary outcome data on ClinicalTrials.gov and in the published literature and to identify the reasons for trial termination. Approximately 12% of trials with results posted on the ClinicalTrials.gov results database (905/7,646) were terminated. Most trials were terminated for reasons other than accumulated data from the trial (68%; 619/905), with an insufficient rate of accrual being the lead reason for termination among these trials (57%; 350/619). Of the remaining trials, 21% (193/905) were terminated based on data from the trial (findings of efficacy or toxicity) and 10% (93/905) did not specify a reason. Overall, data for a primary outcome measure were available on ClinicalTrials.gov and in the published literature for 72% (648/905) and 22% (198/905) of trials, respectively. Primary outcome data were reported on the ClinicalTrials.gov results database and in the published literature more frequently (91% and 46%, respectively) when the decision to terminate was based on data from the trial. Trials terminate for a variety of reasons, not all of which reflect failures in the process or an inability to achieve the intended goals. Primary outcome data were reported most often when termination was based on data from the trial. Further research is needed to identify best practices for disseminating the experience and data resulting from terminated trials in order to help ensure maximal societal benefit from the investments of trial participants and others involved with the study. JF - PloS one AU - Williams, Rebecca J AU - Tse, Tony AU - DiPiazza, Katelyn AU - Zarin, Deborah A AD - National Library of Medicine (NLM), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, United States of America. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 5 KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Outcome Assessment (Health Care) KW - Early Termination of Clinical Trials KW - Databases, Factual KW - Clinical Trials as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683759730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Terminated+Trials+in+the+ClinicalTrials.gov+Results+Database%3A+Evaluation+of+Availability+of+Primary+Outcome+Data+and+Reasons+for+Termination.&rft.au=Williams%2C+Rebecca+J%3BTse%2C+Tony%3BDiPiazza%2C+Katelyn%3BZarin%2C+Deborah+A&rft.aulast=Williams&rft.aufirst=Rebecca&rft.date=2015-01-01&rft.volume=10&rft.issue=5&rft.spage=e0127242&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0127242 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-04-18 N1 - Date created - 2015-05-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: BMJ. 2010;340:c869 [20332511] JAMA. 2014 Mar 12;311(10):1045-51 [24618966] J Clin Oncol. 2010 Dec 10;28(35):5197-201 [21060029] N Engl J Med. 2011 Mar 3;364(9):852-60 [21366476] Am J Bioeth. 2011 Mar;11(3):2-10 [21400374] Kennedy Inst Ethics J. 2011 Mar;21(1):51-78 [21598846] Acad Med. 2011 Nov;86(11):1360-6 [21952064] BMJ. 2012;344:d7292 [22214755] Clin Cancer Res. 2012 Jan 1;18(1):256-62 [21976533] JAMA. 2012 May 2;307(17):1838-47 [22550198] N Engl J Med. 2013 Nov 14;369(20):1926-34 [24224625] Ann Intern Med. 2014 Apr 1;160(7):477-83 [24687070] Am Heart J. 2014 Aug;168(2):213-9.e1 [25066561] J Natl Cancer Inst. 2014 Sep;106(9). pii: dju229. doi: 10.1093/jnci/dju229 [25190726] BMJ. 2014;349:g6870 [25491195] BMJ. 2014;349:g7089 [25499097] Clin Trials. 2015 Feb;12(1):77-83 [25475878] JAMA. 2014 Mar 12;311(10):1063-5 [24618969] JAMA. 2003 Apr 23-30;289(16):2128-31 [12709471] CMAJ. 2004 Sep 28;171(7):735-40 [15451835] Lancet. 1991 Apr 13;337(8746):867-72 [1672966] Circulation. 1994 Jun;89(6):2892-907 [8205706] JAMA. 2005 Nov 2;294(17):2203-9 [16264162] J Am Med Inform Assoc. 2007 May-Jun;14(3):253-63 [17329729] JAMA. 2007 May 16;297(19):2112-20 [17507347] N Engl J Med. 2008 Jan 17;358(3):252-60 [18199864] PLoS Med. 2008 Sep 23;5(9):e191 [18816163] Chest. 2009 Jul;136(1):295-303 [19584212] Chest. 2009 Jul;136(1):304-5 [19584213] J Oncol Pract. 2013 Nov;9(6):267-76 [24130252] PLoS Med. 2013 Dec;10(12):e1001566; discussion e1001566 [24311990] JAMA. 2010 Mar 24;303(12):1180-7 [20332404] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0127242 ER - TY - JOUR T1 - Post-translational structural modifications of immunoglobulin G and their effect on biological activity AN - 1680445221; PQ0001342384 AB - The size, heterogeneity, and biological production process of protein therapeutics like monoclonal, antibodies create unique challenges for their analysis and regulation compared with small molecules. Complete structural characterization of a molecule 1000-fold heavier than aspirin is no small feat. Biological post-translational modifications such as glycosylation further complicate their characterization and regulation. Even approved protein therapeutics are known to contain multiple structural variants in differing amounts. Structural modification occurs during production and storage as well as within patients after administration. Thus, the goals of manufacturers and regulators are to control and characterize this heterogeneity, not take on the impossible task of eliminating it. The aim of this review is to describe the structural heterogeneities known to occur with immunoglobulin G (IgG), note current detection and analytical strategies, establish their causes, and define their potential effects on the ultimate safety, purity, and potency of antibody therapeutics when known. JF - Analytical and Bioanalytical Chemistry AU - Hmiel, Laura K AU - Brorson, Kurt A AU - Boyne, Michael T, II AD - Center for Drug Evaluation and Research, Office of Testing and Research, Division of Pharmaceutical Analysis, United States Food and Drug Administration, Saint Louis, MO 63110, USA, michael.boyne@fda.hhs.gov PY - 2015 SP - 79 EP - 94 PB - Springer Science+Business Media VL - 407 IS - 1 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts; Immunology Abstracts KW - IgG KW - Post-translational modifications KW - Bioprocess KW - Monoclonal antibodies KW - Effector function KW - Safety KW - Glycosylation KW - Storage KW - Post-translation KW - Aspirin KW - Administration KW - Reviews KW - Immunoglobulin G KW - Proteins KW - Regulations KW - Heterogeneity KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680445221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Post-translational+structural+modifications+of+immunoglobulin+G+and+their+effect+on+biological+activity&rft.au=Hmiel%2C+Laura+K%3BBrorson%2C+Kurt+A%3BBoyne%2C+Michael+T%2C+II&rft.aulast=Hmiel&rft.aufirst=Laura&rft.date=2015-01-01&rft.volume=407&rft.issue=1&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-014-8108-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 183 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Aspirin; Post-translation; Monoclonal antibodies; Reviews; Immunoglobulin G; Glycosylation; Storage; Administration; Safety; Proteins; Regulations; Heterogeneity DO - http://dx.doi.org/10.1007/s00216-014-8108-x ER - TY - JOUR T1 - Approaches to studying and manipulating the enteric microbiome to improve autism symptoms. AN - 1680180280; 25956237 AB - There is a growing body of scientific evidence that the health of the microbiome (the trillions of microbes that inhabit the human host) plays an important role in maintaining the health of the host and that disruptions in the microbiome may play a role in certain disease processes. An increasing number of research studies have provided evidence that the composition of the gut (enteric) microbiome (GM) in at least a subset of individuals with autism spectrum disorder (ASD) deviates from what is usually observed in typically developing individuals. There are several lines of research that suggest that specific changes in the GM could be causative or highly associated with driving core and associated ASD symptoms, pathology, and comorbidities which include gastrointestinal symptoms, although it is also a possibility that these changes, in whole or in part, could be a consequence of underlying pathophysiological features associated with ASD. However, if the GM truly plays a causative role in ASD, then the manipulation of the GM could potentially be leveraged as a therapeutic approach to improve ASD symptoms and/or comorbidities, including gastrointestinal symptoms. One approach to investigating this possibility in greater detail includes a highly controlled clinical trial in which the GM is systematically manipulated to determine its significance in individuals with ASD. To outline the important issues that would be required to design such a study, a group of clinicians, research scientists, and parents of children with ASD participated in an interdisciplinary daylong workshop as an extension of the 1st International Symposium on the Microbiome in Health and Disease with a Special Focus on Autism (www.microbiome-autism.com). The group considered several aspects of designing clinical studies, including clinical trial design, treatments that could potentially be used in a clinical trial, appropriate ASD participants for the clinical trial, behavioral and cognitive assessments, important biomarkers, safety concerns, and ethical considerations. Overall, the group not only felt that this was a promising area of research for the ASD population and a promising avenue for potential treatment but also felt that further basic and translational research was needed to clarify the clinical utility of such treatments and to elucidate possible mechanisms responsible for a clinical response, so that new treatments and approaches may be discovered and/or fostered in the future. JF - Microbial ecology in health and disease AU - Frye, Richard E AU - Slattery, John AU - MacFabe, Derrick F AU - Allen-Vercoe, Emma AU - Parker, William AU - Rodakis, John AU - Adams, James B AU - Krajmalnik-Brown, Rosa AU - Bolte, Ellen AU - Kahler, Stephen AU - Jennings, Jana AU - James, Jill AU - Cerniglia, Carl E AU - Midtvedt, Tore AD - Division of Neurology, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA. ; Department of Psychology and Psychiatry, Western University, London, ON, Canada. ; Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON, Canada. ; Department of Surgery, Duke University, Durham, NC USA. ; N of One: Autism Research Foundation, Dallas, TX, USA. ; School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, AZ, USA. ; Swette Center for Environmental Biotechnology, Biodesign Institute, Arizona State University, Tempe, AZ, USA. ; Private Practice, Benton, AR, USA. ; Department of Developmental Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA. ; National Center for Toxicological Research, Jefferson, AR, USA. ; MTC, Karolinska Institutet, Stockholm, Sweden. Y1 - 2015 PY - 2015 DA - 2015 SP - 26878 VL - 26 SN - 0891-060X, 0891-060X KW - short chain fatty acids KW - Clostridia KW - mitochondria KW - fecal microbiota transplantation (FMT) KW - probiotic KW - microbiome KW - vancomycin KW - autism spectrum disorder KW - clinical trials KW - gastrointestinal UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680180280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+ecology+in+health+and+disease&rft.atitle=Approaches+to+studying+and+manipulating+the+enteric+microbiome+to+improve+autism+symptoms.&rft.au=Frye%2C+Richard+E%3BSlattery%2C+John%3BMacFabe%2C+Derrick+F%3BAllen-Vercoe%2C+Emma%3BParker%2C+William%3BRodakis%2C+John%3BAdams%2C+James+B%3BKrajmalnik-Brown%2C+Rosa%3BBolte%2C+Ellen%3BKahler%2C+Stephen%3BJennings%2C+Jana%3BJames%2C+Jill%3BCerniglia%2C+Carl+E%3BMidtvedt%2C+Tore&rft.aulast=Frye&rft.aufirst=Richard&rft.date=2015-01-01&rft.volume=26&rft.issue=&rft.spage=26878&rft.isbn=&rft.btitle=&rft.title=Microbial+ecology+in+health+and+disease&rft.issn=0891060X&rft_id=info:doi/10.3402%2Fmehd.v26.26878 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-09 N1 - Date created - 2015-05-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3402/mehd.v26.26878 ER - TY - JOUR T1 - Rural Affordable Care Act Outreach and Enrollment: What We Learned During the First Marketplace Open Enrollment Period AN - 1680147032; 2011-777185 AB - As part of the Patient Protection and Affordable Care Act (Affordable Care Act) of 2010, 2 new opportunities for health care coverage were established for many uninsured individuals beginning on January 1, 2014. The first opportunity was through Medicaid expansion where states had the opportunity to expand Medicaid coverage to individuals with household incomes up to 133% of the federal poverty level. The second opportunity was through the establishment of Health Insurance Marketplaces where individuals could purchase private health plans and potentially qualify for financial assistance in paying for their plans. The Office of Rural Health Policy (ORHP) provided supplemental grant awards to help stimulate Affordable Care Act outreach and education efforts in rural communities that were being served by the Rural Health Care Services Outreach (Outreach) Grant Program. As a result, Outreach grantees enrolled 9,300 rural Americans during the initial Open Enrollment period. Valuable outreach and enrollment lessons were learned from rural communities based on discussions with the Outreach grantees who received the supplemental funding. These lessons will help rural communities prepare for the next Open Enrollment period. Adapted from the source document. JF - The Journal of Rural Health AU - Kwon, Linda AD - Health Resources and Services Administration, Office of Rural Health Policy, Rockville, Maryland. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 1 EP - 3 PB - John Wiley & Sons, Inc. VL - 31 IS - 1 SN - 0890-765X, 0890-765X KW - Health conditions and policy - Health and health policy KW - Law and ethics - Law and jurisprudence KW - Health conditions and policy - Medicine and health care KW - Social conditions and policy - Public welfare and social services KW - Education and education policy - Education KW - Social conditions and policy - Rural conditions KW - Business and service sector - Insurance KW - Population groups, population policy, and demographics - Demography and census KW - Business and service sector - Accounting KW - Social conditions and policy - Social conditions and problems KW - Economic conditions and policy - Economic conditions KW - United States KW - Medicaid program KW - Health insurance KW - Patients KW - Income KW - Education KW - Uninsured persons KW - Poverty KW - Households KW - Health policy KW - Medical service KW - Rural education KW - Legislation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680147032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Rural+Affordable+Care+Act+Outreach+and+Enrollment%3A+What+We+Learned+During+the+First+Marketplace+Open+Enrollment+Period&rft.au=Kwon%2C+Linda&rft.aulast=Kwon&rft.aufirst=Linda&rft.date=2015-01-01&rft.volume=31&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fjrh.12100 LA - English DB - PAIS Index N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Health policy; Legislation; United States; Medical service; Medicaid program; Rural education; Health insurance; Education; Households; Income; Patients; Poverty; Uninsured persons DO - http://dx.doi.org/10.1111/jrh.12100 ER - TY - JOUR T1 - Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions AN - 1676358111; PQ0001427097 AB - Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus. JF - Journal of Immunology Research AU - Dowall, S D AU - Graham, V A AU - Corbin-Lickfett, K AU - Empig, C AU - Schlunegger, K AU - Bruce, C B AU - Easterbrook, L AU - Hewson, R AD - Public Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UK, stuart.dowall@phe.gov.uk Y1 - 2015/01// PY - 2015 DA - Jan 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-8861, 2314-8861 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Virions KW - Mortality KW - Antibodies KW - Immunology KW - Hemorrhagic fever KW - Ebola virus KW - Vaccines KW - Antiviral activity KW - F 06905:Vaccines KW - V 22350:Immunology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676358111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology+Research&rft.atitle=Effective+Binding+of+a+Phosphatidylserine-Targeting+Antibody+to+Ebola+Virus+Infected+Cells+and+Purified+Virions&rft.au=Dowall%2C+S+D%3BGraham%2C+V+A%3BCorbin-Lickfett%2C+K%3BEmpig%2C+C%3BSchlunegger%2C+K%3BBruce%2C+C+B%3BEasterbrook%2C+L%3BHewson%2C+R&rft.aulast=Dowall&rft.aufirst=S&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology+Research&rft.issn=23148861&rft_id=info:doi/10.1155%2F2015%2F347903 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 2 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Virions; Antibodies; Hemorrhagic fever; Vaccines; Antiviral activity; Mortality; Immunology; Ebola virus DO - http://dx.doi.org/10.1155/2015/347903 ER - TY - JOUR T1 - The Global Ecology and Epidemiology of West Nile Virus AN - 1676355989; PQ0001427376 AB - Since its initial isolation in Uganda in 1937 through the present, West Nile virus (WNV) has become an important cause of human and animal disease worldwide. WNV, an enveloped virus of the genus Flavivirus , is naturally maintained in an enzootic cycle between birds and mosquitoes, with occasional epizootic spillover causing disease in humans and horses. The mosquito vectors for WNV are widely distributed worldwide, and the known geographic range of WNV transmission and disease has continued to increase over the past 77 years. While most human infections with WNV are asymptomatic, severe neurological disease may develop resulting in long-term sequelae or death. Surveillance and preventive measures are an ongoing need to reduce the public health impact of WNV in areas with the potential for transmission. JF - BioMed Research International AU - Chancey, Caren AU - Grinev, Andriyan AU - Volkova, Evgeniya AU - Rios, Maria AD - United States Food and Drug Administration, Center for Biologics Evaluation and Research, Silver Spring, MD 20993-0002, USA, maria.rios@fda.hhs.gov Y1 - 2015/01// PY - 2015 DA - Jan 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Mortality KW - Neurological diseases KW - Complications KW - Horses KW - Vectors KW - Uganda KW - Epizootics KW - Infection KW - Flavivirus KW - Disease transmission KW - Public health KW - Aves KW - Ecology KW - Epidemiology KW - West Nile virus KW - Animal diseases KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - W 30965:Miscellaneous, Reviews KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1676355989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=The+Global+Ecology+and+Epidemiology+of+West+Nile+Virus&rft.au=Chancey%2C+Caren%3BGrinev%2C+Andriyan%3BVolkova%2C+Evgeniya%3BRios%2C+Maria&rft.aulast=Chancey&rft.aufirst=Caren&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F376230 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Number of references - 2 N1 - Last updated - 2015-10-15 N1 - SubjectsTermNotLitGenreText - Neurological diseases; Epidemiology; Complications; Vectors; Epizootics; Infection; Public health; Disease transmission; Ecology; Aves; Mortality; Horses; Animal diseases; West Nile virus; Flavivirus; Uganda DO - http://dx.doi.org/10.1155/2015/376230 ER - TY - JOUR T1 - Farm Work-Related Asthma Among US Primary Farm Operators AN - 1668272021; PQ0001114142 AB - The objective of this study was to estimate the prevalence of current asthma and the proportion of current asthma that is related to work on the farm among primary farm operators. The 2011 Farm and Ranch Safety Survey data were used to produce estimates and prevalence odds ratios. An estimated 5.1% of farm operators had asthma. Of these, 15.4% had farm work-related asthma. Among operators with farm work-related asthma, 54.8% (95% confidence interval [CI]: 41.8%-68.2%) had an asthma attack in the prior 12 months and 33.3% (95% CI: 21.2%-45.4%) had an asthma attack that occurred while doing farm work. Of those who had an asthma attack that occurred while doing farm work, 65.0% associated their asthma attack with plant/tree materials. This study provides updated information on asthma and the proportion of current asthma that is related to work on the farm and identifies certain groups of farm operators that might benefit from workplace asthma prevention intervention. JF - Journal of Agromedicine AU - Mazurek, Jacek M AU - White, Gretchen E AU - Rodman, Chad AU - Schleiff, Patricia L AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA PY - 2015 SP - 31 EP - 42 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 20 IS - 1 SN - 1059-924X, 1059-924X KW - Health & Safety Science Abstracts KW - Prevention KW - Farms KW - Trees KW - Safety KW - Asthma KW - Ranching KW - Intervention KW - Respiratory diseases KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668272021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Agromedicine&rft.atitle=Farm+Work-Related+Asthma+Among+US+Primary+Farm+Operators&rft.au=Mazurek%2C+Jacek+M%3BWhite%2C+Gretchen+E%3BRodman%2C+Chad%3BSchleiff%2C+Patricia+L&rft.aulast=Mazurek&rft.aufirst=Jacek&rft.date=2015-01-01&rft.volume=20&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Journal+of+Agromedicine&rft.issn=1059924X&rft_id=info:doi/10.1080%2F1059924X.2014.976729 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Prevention; Farms; Trees; Safety; Intervention; Ranching; Asthma; Respiratory diseases DO - http://dx.doi.org/10.1080/1059924X.2014.976729 ER - TY - JOUR T1 - Vitamin D status and associated factors of deficiency among Jordanian children of preschool age AN - 1668256274; PQ0001182115 AB - Background/ Objectives: Vitamin D deficiency in children remains a global concern. Although literature exists on the vitamin D status and its risk factors among children in the Middle East, findings have yielded mixed results, and large, representative community studies are lacking.Subjects/ Methods: In a nationally representative survey of 1077 Jordanian children of preschool age (12-59 months) in Spring 2010, we measured 25(OH)D sub(3) concentrations by liquid chromatography-tandem mass spectrometry and calculated prevalence ratios for deficiency associated with various factors. Results: Results showed 19.8% (95% confidence interval (CI): 16.4-23.3%) deficiency (<12 ng/ml) and 56.5% (95% CI: 52.0-61.0%) insufficiency (<20 ng/ml). In adjusted models, prevalence of deficiency was higher for females compared with males (prevalence ratio (PR)=1.74, 95% CI: 1.22-2.47, P=0.002) and lower for children 24-35 months of age (PR=0.64, 95% CI: 0.44-0.92, P=0.018) compared with children 12-23 months of age. In rural areas, there was no difference in prevalence of vitamin D deficiency between those whose mothers had/did not have vitamin D deficiency (P=0.312); however, in urban areas, prevalence of vitamin D deficiency was 3.18 times greater among those whose mothers were vitamin D deficient compared with those whose mothers were not deficient (P=0.000). Conclusions: Vitamin D deficiency and insufficiency pose significant public health problems in Jordanian children with female children disproportionately affected. Strong associations between vitamin D status in children and urban residency and maternal vitamin D status suggest that the behaviors related to sun exposure in urban mothers likely also affect the sun exposure and thus vitamin D status of their children. JF - European Journal of Clinical Nutrition AU - Nichols, E K AU - Khatib, I M D AU - Aburto, N J AU - Serdula, M K AU - Scanlon, K S AU - Wirth, J P AU - Sullivan, K M AD - Epidemic Intelligence Service assigned to the Division of Nutrition, Physical Activity and Obesity, Centers for Disease Control and Prevention, U.S. Public Health Service, Atlanta, GA, USA Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 90 EP - 95 PB - Nature Publishing Group VL - 69 IS - 1 SN - 0954-3007, 0954-3007 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Age KW - Vitamin D KW - Behavior KW - Risk factors KW - Sun KW - Mass spectrometry KW - Children KW - Middle East KW - Public health KW - Rural areas KW - Urban areas KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1668256274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Nutrition&rft.atitle=Vitamin+D+status+and+associated+factors+of+deficiency+among+Jordanian+children+of+preschool+age&rft.au=Nichols%2C+E+K%3BKhatib%2C+I+M+D%3BAburto%2C+N+J%3BSerdula%2C+M+K%3BScanlon%2C+K+S%3BWirth%2C+J+P%3BSullivan%2C+K+M&rft.aulast=Nichols&rft.aufirst=E&rft.date=2015-01-01&rft.volume=69&rft.issue=1&rft.spage=90&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Nutrition&rft.issn=09543007&rft_id=info:doi/10.1038%2Fejcn.2014.142 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Age; Vitamin D; Behavior; Risk factors; Sun; Mass spectrometry; Children; Urban areas; Rural areas; Public health; Middle East DO - http://dx.doi.org/10.1038/ejcn.2014.142 ER - TY - JOUR T1 - ICD-11: A COMPREHENSIVE PICTURE OF HEALTH, AN UPDATE ON THE ICD-ICF JOINT USE INITIATIVE AN - 1665159992 AB - Background: This is a follow-up of the special report Towards the joint use of ICD and ICF: A call for contribution, published by the Journal of Rehabilitation Medicine in 2012, which introduced an initiative of using the International Classification of Diseases (ICD) and the International Classification of Functioning, Disability and Health (ICF) in a complementary way in clinical practice. Recognizing the merits of using the ICD and ICF jointly, the World Health Organization (WHO) introduced so-called functioning properties in the ICD-11. The first step in this ICD-ICF joint use initiative revealed 103 rehabilitation-relevant health conditions for which functioning properties were to be identified. Afterwards experts were recruited to identify the functioning properties for the health conditions for which no ICF Core Sets were available and all the functioning properties were integrated in the beta-version of ICD-11. Objective: The objective of this special report is to present the outcome of the recruitment and training of the contributing experts, and to provide an update on the current status of identifying functioning properties and their integration in ICD-11. Discussion: Having functioning properties in the ICD-11 achieves a milestone in depicting health information in an integrated and comprehensive manner. Explicitly identifying functioning properties for specific health conditions further reinforces the importance of acquiring a broader and more meaningful picture of a personʼs health, and can guide clinical decision-making. JF - Journal of Rehabilitation Medicine AU - Selb, Melissa AU - Kohler, Friedbert AU - Nicol, Molly Meri Robinson AU - Riberto, Marcelo AU - Stucki, Gerold AU - Kennedy, Cille AU - Ustun, Bedirhan AD - WHO Collaborating Centre for the Family of International Classifications in Germany (at DIMDI); Swiss Paraplegic Research, Nottwil, Switzerland; ICF Research Branch, c/o Swiss Paraplegic Research, Guido-Zach-Strasse 4, CH-6207 Nottwil, Switzerland ; Braeside Hospital, Wetherill Park; School of Public Health and Community Medicine, Faculty of Medicine, University of NSW, Sydney, Australia ; World Health Organization, Classification, Terminology and Standards, Geneva, Switzerland ; University of Sao Paulo, Ribeirao Medical School, Sao Paulo, Brazil ; ICF Research Branch; WHO Collaborating Centre for the Family of International Classifications in Germany (at DIMDI); Swiss Paraplegic Research, Nottwil, Switzerland; Department of Health Sciences and Health Policy, University of Lucerne; SPF, Nottwil, Switerzland ; US Department of Health and Human Services, Washington, USA ; WHO Collaborating Centre for the Family of International Classifications in Germany (at DIMDI); Swiss Paraplegic Research, Nottwil, Switzerland; ICF Research Branch, c/o Swiss Paraplegic Research, Guido-Zach-Strasse 4, CH-6207 Nottwil, Switzerland Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 2 EP - 8 CY - Stockholm PB - Taylor & Francis Ltd. VL - 47 IS - 1 SN - 1650-1977 KW - Medical Sciences KW - International Classification of Diseases KW - ICF KW - classification KW - functioning KW - ICD revision KW - rehabilitation KW - Classification KW - Conditions KW - Clinical decision making KW - Clinical practice KW - Decision making KW - Disability KW - Experts KW - Health information KW - Recruitment KW - Rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665159992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Rehabilitation+Medicine&rft.atitle=ICD-11%3A+A+COMPREHENSIVE+PICTURE+OF+HEALTH%2C+AN+UPDATE+ON+THE+ICD-ICF+JOINT+USE+INITIATIVE&rft.au=Selb%2C+Melissa%3BKohler%2C+Friedbert%3BNicol%2C+Molly+Meri+Robinson%3BRiberto%2C+Marcelo%3BStucki%2C+Gerold%3BKennedy%2C+Cille%3BUstun%2C+Bedirhan&rft.aulast=Selb&rft.aufirst=Melissa&rft.date=2015-01-01&rft.volume=47&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Journal+of+Rehabilitation+Medicine&rft.issn=16501977&rft_id=info:doi/10.2340%2F16501977-1928 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - World Health Organization N1 - Date revised - 2015-02-05 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.2340/16501977-1928 ER - TY - JOUR T1 - Introduction to Special Section: Behavioral Health and Disasters—Planning for the Next Time AN - 1665151449 JF - Journal of Behavioral Health Services & Research AU - Larson, Sharon AU - Gould, Deborah W AD - Substance Abuse and Mental Health Services Administration, Atlanta, GA, USA ; Centers for Disease Control and Prevention, Atlanta, GA, USA dgw8@cdc.gov; Substance Abuse and Mental Health Services Administration, Atlanta, GA, USA Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 3 EP - 5 CY - Gaithersburg PB - Springer Science & Business Media VL - 42 IS - 1 SN - 1094-3412 KW - Public Health And Safety KW - Disasters KW - Health behaviour UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665151449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Introduction+to+Special+Section%3A+Behavioral+Health+and+Disasters%E2%80%94Planning+for+the+Next+Time&rft.au=Larson%2C+Sharon%3BGould%2C+Deborah+W&rft.aulast=Larson&rft.aufirst=Sharon&rft.date=2015-01-01&rft.volume=42&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-014-9444-5 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1007/s11414-014-9444-5 ER - TY - JOUR T1 - Epidemiologic Studies of Behavioral Health Following the Deepwater Horizon Oil Spill: Limited Impact or Limited Ability to Measure? AN - 1665151041 AB - Two large-scale epidemiologic federal surveys conducted in the Gulf Coast following the Deepwater Horizon oil spill and intended to measure its impact on mental disorders and substance use found less dramatic results than had been anticipated. However, several smaller-scale studies conducted shortly after the spill did find increases in the prevalence of certain psychological problems among individuals surveyed. Previous federal studies conducted following two disasters—the destruction of the World Trade Center (WTC) and Hurricanes Katrina and Rita—found few statistically significant changes in behavioral disorders in the wake of those events, except for individuals displaced from their homes by Katrina for 2 weeks or more. In this commentary, the authors discuss questions raised by these mixed results regarding the limitations of such studies, the behavioral health impact of the Deepwater Horizon spill compared to disasters causing more widespread loss of life and destruction of property, and the ways in which data collection following disasters might be improved to benefit public health planners. JF - Journal of Behavioral Health Services & Research AU - Teich, Judith L AU - Pemberton, Michael R AD - Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA judith.teich@samhsa.hhs.gov; RTI International, 3040 Cornwallis Road, Research Triangle Park, Durham, NC, 27709-2194, USA ; Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 77 EP - 85 CY - Gaithersburg PB - Springer Science & Business Media VL - 42 IS - 1 SN - 1094-3412 KW - Public Health And Safety KW - Behaviour disorders KW - Behavioural changes KW - Health behaviour KW - Destruction KW - Disasters KW - Hurricanes KW - Petroleum KW - Planners KW - Property KW - Psychiatric disorders KW - Psychological problems KW - Public health KW - World trade UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665151041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Epidemiologic+Studies+of+Behavioral+Health+Following+the+Deepwater+Horizon+Oil+Spill%3A+Limited+Impact+or+Limited+Ability+to+Measure%3F&rft.au=Teich%2C+Judith+L%3BPemberton%2C+Michael+R&rft.aulast=Teich&rft.aufirst=Judith&rft.date=2015-01-01&rft.volume=42&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-014-9395-x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - World Trade Center-New York City NY N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-25 DO - http://dx.doi.org/10.1007/s11414-014-9395-x ER - TY - JOUR T1 - Behavioral Health in the Gulf Coast Region Following the Deepwater Horizon Oil Spill: Findings from Two Federal Surveys AN - 1665150881 AB - This article summarizes findings from two large-scale, population-based surveys conducted by Substance Abuse and Mental Health Services Administration (SAMHSA) and Centers for Disease Control and Prevention (CDC) in the Gulf Coast region following the 2010 Deepwater Horizon oil spill, to measure the prevalence of mental and substance use disorders, chronic health conditions, and utilization of behavioral health services. Although many area residents undoubtedly experienced increased levels of anxiety and stress following the spill, findings suggest only modest or minimal changes in behavioral health at the aggregate level before and after the spill. The studies do not address potential long-term effects of the spill on physical and behavioral health nor did they target subpopulations that might have been most affected by the spill. Resources mobilized to reduce the economic and behavioral health impacts of the spill on coastal residents—including compensation for lost income from BP and increases in available mental health services—may have resulted in a reduction in potential mental health problems. JF - Journal of Behavioral Health Services & Research AU - Gould, Deborah W AU - Teich, Judith L AU - Pemberton, Michael R AU - Pierannunzi, Carol AU - Larson, Sharon AD - Division of Health Informatics and Surveillance, Centers for Disease Control and Prevention, Atlanta, Georgia ; Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration, Rockville, MD, USA Judith.teich@samhsa.hhs.gov Judith.teich@samhsa.hhs.gov; RTI International, New Orleans, LA, USA ; Division of Health Informatics and Surveillance, Centers for Disease Control and Prevention, Atlanta, Georgia Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 6 EP - 22 CY - Gaithersburg PB - Springer Science & Business Media VL - 42 IS - 1 SN - 1094-3412 KW - Public Health And Safety KW - Chronic sickness KW - Behavioural changes KW - Health behaviour KW - Compensation KW - Health KW - Health problems KW - Health services KW - Health status KW - Long term effects KW - Mental health services KW - Mental illness KW - Petroleum KW - Psychiatric disorders KW - Social services KW - Substance abuse disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665150881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=Behavioral+Health+in+the+Gulf+Coast+Region+Following+the+Deepwater+Horizon+Oil+Spill%3A+Findings+from+Two+Federal+Surveys&rft.au=Gould%2C+Deborah+W%3BTeich%2C+Judith+L%3BPemberton%2C+Michael+R%3BPierannunzi%2C+Carol%3BLarson%2C+Sharon&rft.aulast=Gould&rft.aufirst=Deborah&rft.date=2015-01-01&rft.volume=42&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-014-9441-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Centers for Disease Control & Prevention--CDC N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-18 DO - http://dx.doi.org/10.1007/s11414-014-9441-8 ER - TY - JOUR T1 - Modeling the interaction between quinolinate and the receptor for advanced glycation end products (RAGE): relevance for early neuropathological processes. AN - 1662636529; 25757085 AB - The receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor involved in neurodegenerative and inflammatory disorders. RAGE induces cellular signaling upon binding to a variety of ligands. Evidence suggests that RAGE up-regulation is involved in quinolinate (QUIN)-induced toxicity. We investigated the QUIN-induced toxic events associated with early noxious responses, which might be linked to signaling cascades leading to cell death. The extent of early cellular damage caused by this receptor in the rat striatum was characterized by image processing methods. To document the direct interaction between QUIN and RAGE, we determined the binding constant (Kb) of RAGE (VC1 domain) with QUIN through a fluorescence assay. We modeled possible binding sites of QUIN to the VC1 domain for both rat and human RAGE. QUIN was found to bind at multiple sites to the VC1 dimer, each leading to particular mechanistic scenarios for the signaling evoked by QUIN binding, some of which directly alter RAGE oligomerization. This work contributes to the understanding of the phenomenon of RAGE-QUIN recognition, leading to the modulation of RAGE function. JF - PloS one AU - Serratos, Iris N AU - Castellanos, Pilar AU - Pastor, Nina AU - Millán-Pacheco, César AU - Rembao, Daniel AU - Pérez-Montfort, Ruy AU - Cabrera, Nallely AU - Reyes-Espinosa, Francisco AU - Díaz-Garrido, Paulina AU - López-Macay, Ambar AU - Martínez-Flores, Karina AU - López-Reyes, Alberto AU - Sánchez-García, Aurora AU - Cuevas, Elvis AU - Santamaria, Abel AD - Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, México D.F., México; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, SSA, México D.F., México. ; Departamento de Ingeniería Eléctrica, Universidad Autónoma Metropolitana-Iztapalapa, México D.F., México. ; Facultad de Ciencias, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, México. ; Instituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México. ; Neuropatología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, México D.F., México. ; Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F., México. ; Departamento de Química, Universidad Autónoma Metropolitana-Iztapalapa, México D.F., México. ; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, SSA, México D.F., México. ; Laboratorio de Líquido Sinovial, Instituto Nacional de Rehabilitación, SSA, México D.F., México. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 3 KW - Advanced Glycosylation End Product-Specific Receptor KW - 0 KW - Ager protein, rat KW - Quinolinic Acid KW - F6F0HK1URN KW - Index Medicus KW - Animals KW - Molecular Docking Simulation KW - Brain -- pathology KW - Oxidative Stress KW - Neurodegenerative Diseases -- metabolism KW - Rats, Wistar KW - Neurodegenerative Diseases -- pathology KW - Brain -- metabolism KW - Protein Binding KW - Male KW - Quinolinic Acid -- chemistry KW - Quinolinic Acid -- physiology KW - Advanced Glycosylation End Product-Specific Receptor -- metabolism KW - Advanced Glycosylation End Product-Specific Receptor -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1662636529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Modeling+the+interaction+between+quinolinate+and+the+receptor+for+advanced+glycation+end+products+%28RAGE%29%3A+relevance+for+early+neuropathological+processes.&rft.au=Serratos%2C+Iris+N%3BCastellanos%2C+Pilar%3BPastor%2C+Nina%3BMill%C3%A1n-Pacheco%2C+C%C3%A9sar%3BRembao%2C+Daniel%3BP%C3%A9rez-Montfort%2C+Ruy%3BCabrera%2C+Nallely%3BReyes-Espinosa%2C+Francisco%3BD%C3%ADaz-Garrido%2C+Paulina%3BL%C3%B3pez-Macay%2C+Ambar%3BMart%C3%ADnez-Flores%2C+Karina%3BL%C3%B3pez-Reyes%2C+Alberto%3BS%C3%A1nchez-Garc%C3%ADa%2C+Aurora%3BCuevas%2C+Elvis%3BSantamaria%2C+Abel&rft.aulast=Serratos&rft.aufirst=Iris&rft.date=2015-01-01&rft.volume=10&rft.issue=3&rft.spage=e0120221&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0120221 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-13 N1 - Date created - 2015-03-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Allergy. 2013 Dec;68(12):1546-54 [24266677] Oncogene. 2014 Jan 30;33(5):567-77 [23318458] J Pathol. 2010 May;221(1):13-25 [20186922] Neurosci Lett. 2010 Apr 26;474(2):74-8 [20223279] Ann Med. 2009;41(6):408-22 [19322705] Structure. 2010 Oct 13;18(10):1342-52 [20947022] PLoS One. 2010;5(11):e14123 [21152063] J Biol Chem. 2010 Dec 24;285(52):40762-70 [20943659] J Mol Biol. 2011 Jan 7;405(1):158-72 [20970429] Biochim Biophys Acta. 2011 May;1814(5):592-609 [21354340] Structure. 2011 May 11;19(5):722-32 [21565706] J Chem Inf Model. 2011 Oct 24;51(10):2778-86 [21919503] J Biol Chem. 2012 Feb 10;287(7):5133-44 [22194616] Nat Rev Neurosci. 2012 Jul;13(7):465-77 [22678511] J Neurol Sci. 2012 Nov 15;322(1-2):187-91 [22749004] J Neurol Sci. 2012 Dec 15;323(1-2):1-8 [22939820] Cell Signal. 2013 Apr;25(4):939-54 [23333461] Neurotox Res. 2013 May;23(4):393-400 [23065398] ACS Chem Biol. 2013 Jul 19;8(7):1611-20 [23679870] Proteins. 2014 Mar;82(3):405-14 [24038671] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] Diabetes. 2001 Dec;50(12):2792-808 [11723063] J Neurochem. 2003 Jul;86(2):479-88 [12871589] Clin Chem Lab Med. 2003 Jul;41(7):852-9 [12940508] Biochemistry. 2004 Mar 23;43(11):3255-63 [15023076] PLoS One. 2014;9(3):e91512 [24632560] Mol Cell Biochem. 2014 May;390(1-2):271-80 [24510323] Circ J. 2014;78(5):1197-205 [24599045] J Exp Med. 2014 May 5;211(5):749-50 [24778420] Biochemistry. 2014 May 27;53(20):3327-35 [24824951] J Anat. 2004 Apr;204(4):271-81 [15061753] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Neurochem Int. 2004 Dec;45(8):1175-83 [15380627] Biochemistry. 1982 May 25;21(11):2600-6 [7093207] Anal Biochem. 1982 Nov 15;127(1):159-63 [7165082] Life Sci. 1984 Jul 2;35(1):19-32 [6234446] Can Dis Wkly Rep. 1990 Sep;16 Suppl 1E:47-57; discussion 57-8 [1966279] Science. 1993 Oct 29;262(5134):689-95 [7901908] J Mol Graph. 1996 Feb;14(1):33-8, 27-8 [8744570] Biochim Biophys Acta. 2005 Jun 30;1741(1-2):199-205 [15882940] Glycobiology. 2005 Jul;15(7):16R-28R [15764591] Arthritis Rheum. 2005 Aug;52(8):2376-85 [16052547] J Comput Chem. 2005 Dec;26(16):1781-802 [16222654] Protein Expr Purif. 2006 May;47(1):25-35 [16510295] Nat Immunol. 2007 May;8(5):487-96 [17417641] EMBO J. 2007 Aug 22;26(16):3868-78 [17660747] CNS Neurol Disord Drug Targets. 2007 Dec;6(6):398-410 [18220779] Curr Protoc Cell Biol. 2004 Sep;Chapter 17:Unit 17.8 [18228446] BMC Bioinformatics. 2008;9:40 [18215316] Curr Protoc Protein Sci. 2004 Nov;Chapter 3:Unit 3.1 [18429266] J Neurochem. 2008 May;105(3):677-89 [18194214] J Biol Chem. 2008 May 23;283(21):14581-9 [18348981] FASEB J. 2008 Oct;22(10):3716-27 [18603587] Biochemistry. 2008 Nov 25;47(47):12299-311 [19032093] J Transl Med. 2009;7:17 [19292913] J Comput Chem. 2009 Jul 30;30(10):1545-614 [19444816] J Neural Transm (Vienna). 2009 Oct;116(10):1201-8 [19597933] Diabetologia. 2009 Nov;52(11):2251-63 [19636529] J Comput Chem. 2010 Jan 30;31(2):455-61 [19499576] Biochemistry. 2010 Feb 23;49(7):1388-95 [20047306] Nat Protoc. 2010 Apr;5(4):725-38 [20360767] PLoS One. 2013;8(6):e65180 [23785412] PLoS One. 2013;8(8):e69669 [23936343] PLoS One. 2013;8(10):e76353 [24098480] J Exp Med. 2013 Oct 21;210(11):2447-63 [24081950] FEBS J. 2013 Dec;280(24):6556-68 [24119142] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0120221 ER - TY - JOUR T1 - Acute inflammatory responses of nanoparticles in an intra-tracheal instillation rat model. AN - 1661327326; 25738830 AB - Exposure to hard metal tungsten carbide cobalt (WC-Co) "dusts" in enclosed industrial environments is known to contribute to the development of hard metal lung disease and an increased risk for lung cancer. Currently, the influence of local and systemic inflammation on disease progression following WC-Co exposure remains unclear. To better understand the relationship between WC-Co nanoparticle (NP) exposure and its resultant effects, the acute local pulmonary and systemic inflammatory responses caused by WC-Co NPs were explored using an intra-tracheal instillation (IT) model and compared to those of CeO2 (another occupational hazard) NP exposure. Sprague-Dawley rats were given an IT dose (0-500 μg per rat) of WC-Co or CeO2 NPs. Following 24-hr exposure, broncho-alveolar lavage fluid and whole blood were collected and analyzed. A consistent lack of acute local pulmonary inflammation was observed in terms of the broncho-alveolar lavage fluid parameters examined (i.e. LDH, albumin, and macrophage activation) in animals exposed to WC-Co NP; however, significant acute pulmonary inflammation was observed in the CeO2 NP group. The lack of acute inflammation following WC-Co NP exposure contrasts with earlier in vivo reports regarding WC-Co toxicity in rats, illuminating the critical role of NP dose and exposure time and bringing into question the potential role of impurities in particle samples. Further, we demonstrated that WC-Co NP exposure does not induce acute systemic effects since no significant increase in circulating inflammatory cytokines were observed. Taken together, the results of this in vivo study illustrate the distinct differences in acute local pulmonary and systemic inflammatory responses to NPs composed of WC-Co and CeO2; therefore, it is important that the outcomes of pulmonary exposure to one type of NPs may not be implicitly extrapolated to other types of NPs. JF - PloS one AU - Armstead, Andrea L AU - Minarchick, Valerie C AU - Porter, Dale W AU - Nurkiewicz, Timothy R AU - Li, Bingyun AD - Biomaterials, Bioengineering & Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Pharmaceutical and Pharmacological Sciences Graduate Program, School of Pharmacy, West Virginia University, Morgantown, West Virginia, United States of America. ; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Center for Cardiovascular and Respiratory Sciences, Robert C. Byrd Health Sciences Center, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America. ; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America. ; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Center for Cardiovascular and Respiratory Sciences, Robert C. Byrd Health Sciences Center, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America. ; Biomaterials, Bioengineering & Nanotechnology Laboratory, Department of Orthopaedics, School of Medicine, West Virginia University, Morgantown, West Virginia, United States of America; Pharmaceutical and Pharmacological Sciences Graduate Program, School of Pharmacy, West Virginia University, Morgantown, West Virginia, United States of America; Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States of America; Mary Babb Randolph Cancer Center, Morgantown, West Virginia, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 3 KW - Interleukin-6 KW - 0 KW - Tumor Necrosis Factor-alpha KW - Tungsten Compounds KW - tungsten carbide KW - 11130-73-7 KW - Cobalt KW - 3G0H8C9362 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Cobalt -- chemistry KW - Interleukin-6 -- metabolism KW - Inflammation -- chemically induced KW - Toxicity Tests, Acute KW - Bronchoalveolar Lavage KW - Inflammation -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Male KW - Tungsten Compounds -- chemistry KW - Pneumonia -- chemically induced KW - Trachea KW - Nanoparticles -- toxicity KW - Pneumonia -- pathology KW - Pneumonia -- metabolism KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1661327326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Acute+inflammatory+responses+of+nanoparticles+in+an+intra-tracheal+instillation+rat+model.&rft.au=Armstead%2C+Andrea+L%3BMinarchick%2C+Valerie+C%3BPorter%2C+Dale+W%3BNurkiewicz%2C+Timothy+R%3BLi%2C+Bingyun&rft.aulast=Armstead&rft.aufirst=Andrea&rft.date=2015-01-01&rft.volume=10&rft.issue=3&rft.spage=e0118778&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0118778 LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0118778 ER - TY - JOUR T1 - Relationships Between Clinico-Epidemiological Patterns of Invasive Meningococcal Infections and Complement Deficiencies in French South Pacific Islands (New Caledonia) AN - 1660435286; PQ0001029016 AB - Purpose: Invasive Meningococcal Disease (IMD) is three fold more common in New Caledonia (NC) than in metropolitan France and many IMD cases (35.7 %) are due to Y and W135 serogroups. The purpose of our study was to identify IMD risk factors in NC. Methods: A retrospective study of all IMD cases that occurred in NC between 2005 and 2011 was conducted. Socio-environmental, clinical and biological data were collected. A search for immune deficiency was proposed to all cases. IMD presentation and outcome were compared according to meningoccal serogroups and the complement deficiency status (C-deficiency). Results: Sixty-six sporadic IMD cases (29 B serogroup, 20 Y or W135, 6 C, 1 A, 10 unknown) occurred in 64 patients often <24 years-old and of Melanesian origin. Five patients died (7.8 %). No socio-environmental risk factors were identified. No asplenia, HIV infection or immunoglobulin deficiencies were found. Two patients had diabetes and 28 of 53 (52.8 %) patients had C-deficiency including 20 (71.4 %) cases of late complement component deficiency. Patients with C-deficiency were mainly Melanesian (92.8 %) originating from the Loyalty Islands (62.1 %). They were mostly infected with Y/W135 (42.9 %) or B serogroups (32.1 %). They often developed later and more severe disease than patients without C-deficiency (need for intensive cares in 60 % versus 28.0 % of cases, p=0.01). Conclusions: A high prevalence of C-deficiency in the Melanesian population may explain epidemiological and clinical features of IMD in NC. Our results imply an adaptation of meningococcal vaccine strategies in NC. JF - Journal of Clinical Immunology AU - Daures, Maguy AU - John, Michele AU - Balter, Cecile Veysseyre AU - Simon, Olivier AU - Barguil, Yann AU - Missotte, Isabelle AU - Grangeon, Jean-Paul AU - Laumond-Barny, Sylvie AU - Noel, Martine AU - Besson-Leaud, Laurent AU - Spasic, Pierre-Emmanuel AU - Suremain, Aurelie AU - Gourinat, Ann-Claire AU - Descloux, Elodie AD - Public Health Service, New Caledonia Health Department, BP N4 - 98851, Noumea, Cedex, New Caledonia, maguy.daures@gmail.com Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 47 EP - 55 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 35 IS - 1 SN - 0271-9142, 0271-9142 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Data processing KW - Adaptations KW - Asplenia KW - Neisseria meningitidis KW - Infection KW - Diabetes mellitus KW - Islands KW - Human immunodeficiency virus KW - Risk factors KW - Invasive meningococcal disease KW - Complement deficiency KW - Vaccines KW - Immunoglobulins KW - J 02400:Human Diseases KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660435286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Immunology&rft.atitle=Relationships+Between+Clinico-Epidemiological+Patterns+of+Invasive+Meningococcal+Infections+and+Complement+Deficiencies+in+French+South+Pacific+Islands+%28New+Caledonia%29&rft.au=Daures%2C+Maguy%3BJohn%2C+Michele%3BBalter%2C+Cecile+Veysseyre%3BSimon%2C+Olivier%3BBarguil%2C+Yann%3BMissotte%2C+Isabelle%3BGrangeon%2C+Jean-Paul%3BLaumond-Barny%2C+Sylvie%3BNoel%2C+Martine%3BBesson-Leaud%2C+Laurent%3BSpasic%2C+Pierre-Emmanuel%3BSuremain%2C+Aurelie%3BGourinat%2C+Ann-Claire%3BDescloux%2C+Elodie&rft.aulast=Daures&rft.aufirst=Maguy&rft.date=2015-01-01&rft.volume=35&rft.issue=1&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Immunology&rft.issn=02719142&rft_id=info:doi/10.1007%2Fs10875-014-0104-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 38 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Adaptations; Data processing; Islands; Invasive meningococcal disease; Risk factors; Complement deficiency; Asplenia; Vaccines; Infection; Immunoglobulins; Human immunodeficiency virus; Neisseria meningitidis DO - http://dx.doi.org/10.1007/s10875-014-0104-6 ER - TY - JOUR T1 - A reliable multiplex genotyping assay for HCV using a suspension bead array AN - 1660402350; PQ0001007980 AB - The genotyping of the hepatitis C virus (HCV) plays an important role in the treatment of HCV because genotype determination has recently been incorporated into the treatment guidelines for HCV infections. Most current genotyping methods are unable to detect mixed genotypes from two or more HCV infections. We therefore developed a multiplex genotyping assay to determine HCV genotypes using a bead array. Synthetic plasmids, genotype panels and standards were used to verify the target-specific primer (TSP) design in the assay, and the results indicated that discrimination efforts using 10 TSPs in a single reaction were extremely successful. Thirty-five specimens were then tested to evaluate the assay performance, and the results were highly consistent with those of direct sequencing, supporting the reliability of the assay. Moreover, the results from samples with mixed HCV genotypes revealed that the method is capable of detecting two different genotypes within a sample. Furthermore, the specificity evaluation results suggested that the assay could correctly identify HCV in HCV/human immunodeficiency virus (HIV) co-infected patients. This genotyping platform enables the simultaneous detection and identification of more than one genotype in a same sample and is able to test 96 samples simultaneously. It could therefore provide a rapid, efficient and reliable method of determining HCV genotypes in the future. This genotyping platform enables the simultaneous detection and identification of more than one genotype in a same sample and is able to test 96 samples simultaneously. It could therefore provide a rapid, efficient, and reliable method of determining HCV genotypes in the future. JF - Microbial Biotechnology AU - Yang, Yi-Chen AU - Wang, Der-Yuan AU - Cheng, Hwei-Fang AU - Chuang, Eric Y AU - Tsai, Mong-Hsun AD - Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 93 EP - 102 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ United Kingdom VL - 8 IS - 1 SN - 1751-7915, 1751-7915 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Hepatitis C virus KW - Human immunodeficiency virus KW - Genotyping KW - Primers KW - Genotypes KW - Infection KW - Plasmids KW - A 01340:Antibiotics & Antimicrobials KW - G 07880:Human Genetics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660402350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Biotechnology&rft.atitle=A+reliable+multiplex+genotyping+assay+for+HCV+using+a+suspension+bead+array&rft.au=Yang%2C+Yi-Chen%3BWang%2C+Der-Yuan%3BCheng%2C+Hwei-Fang%3BChuang%2C+Eric+Y%3BTsai%2C+Mong-Hsun&rft.aulast=Yang&rft.aufirst=Yi-Chen&rft.date=2015-01-01&rft.volume=8&rft.issue=1&rft.spage=93&rft.isbn=&rft.btitle=&rft.title=Microbial+Biotechnology&rft.issn=17517915&rft_id=info:doi/10.1111%2F1751-7915.12140 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Genotyping; Primers; Genotypes; Plasmids; Infection; Hepatitis C virus; Human immunodeficiency virus DO - http://dx.doi.org/10.1111/1751-7915.12140 ER - TY - JOUR T1 - Use of Pharmacotherapies in the Treatment of Alcohol Use Disorders and Opioid Dependence in Primary Care AN - 1660400170; PQ0001106697 AB - Substance-related and addictive disorders are chronic relapsing conditions that substantially impact public health. Effective treatments for these disorders require addressing substance use/dependence comprehensively as well as other associated comorbidities. Comprehensive addressing of substance use in a medical setting involves screening for substance use, addressing substance use directly with the patient, and formulating an appropriate intervention. For alcohol dependence and opioid dependence, pharmacotherapies are available that are safe and effective when utilized in a comprehensive treatment paradigm, such as medication assisted treatment. In primary care, substance use disorders involving alcohol, illicit opioids, and prescription opioid abuse are common among patients who seek primary care services. Primary care providers report low levels of preparedness and confidence in identifying substance-related and addictive disorders and providing appropriate care and treatment. However, new models of service delivery in primary care for individuals with substance-related and addictive disorders are being developed to promote screening, care and treatment, and relapse prevention. The education and training of primary care providers utilizing approved medications for the treatment of alcohol use disorders and opioid dependence in a primary care setting would have important public health impact and reduce the burden of alcohol abuse and opioid dependence. JF - BioMed Research International AU - Lee, Jinhee AU - Kresina, Thomas F AU - Campopiano, Melinda AU - Lubran, Robert AU - Clark, HWestley AD - Center for Substance Abuse Treatment, Substance Abuse and Mental Health Services Administration, Rockville, MD 20857, USA, jinhee.lee@samhsa.hhs.gov Y1 - 2015/01// PY - 2015 DA - Jan 2015 PB - Hindawi Publishing Corporation, P.O. Box 3079 Cuyahoga Falls OH 44223 United States VL - 2015 SN - 2314-6133, 2314-6133 KW - Biotechnology and Bioengineering Abstracts KW - Drug dependence KW - Opioids KW - Addiction KW - Drug abuse KW - Ethanol KW - Public health KW - Models KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660400170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioMed+Research+International&rft.atitle=Use+of+Pharmacotherapies+in+the+Treatment+of+Alcohol+Use+Disorders+and+Opioid+Dependence+in+Primary+Care&rft.au=Lee%2C+Jinhee%3BKresina%2C+Thomas+F%3BCampopiano%2C+Melinda%3BLubran%2C+Robert%3BClark%2C+HWestley&rft.aulast=Lee&rft.aufirst=Jinhee&rft.date=2015-01-01&rft.volume=2015&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BioMed+Research+International&rft.issn=23146133&rft_id=info:doi/10.1155%2F2015%2F137020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 6 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Drug dependence; Opioids; Addiction; Drug abuse; Models; Public health; Ethanol DO - http://dx.doi.org/10.1155/2015/137020 ER - TY - JOUR T1 - Debilitating Lung Disease Among Surface Coal Miners With No Underground Mining Tenure AN - 1660394415; PQ0001169716 AB - Objective: To characterize exposure histories and respiratory disease among surface coal miners identified with progressive massive fibrosis from a 2010 to 2011 pneumoconiosis survey. Methods: Job history, tenure, and radiograph interpretations were verified. Previous radiographs were reviewed when available. Telephone follow-up sought additional work and medical history information. Results: Among eight miners who worked as drill operators or blasters for most of their tenure (median, 35.5 years), two reported poor dust control practices, working in visible dust clouds as recently as 2012. Chest radiographs progressed to progressive massive fibrosis in as few as 11 years. One miner's lung biopsy demonstrated fibrosis and interstitial accumulation of macrophages containing abundant silica, aluminum silicate, and titanium dust particles. Conclusions: Overexposure to respirable silica resulted in progressive massive fibrosis among current surface coal miners with no underground mining tenure. Inadequate dust control during drilling/blasting is likely an important etiologic factor. JF - Journal of Occupational and Environmental Medicine AU - Halldin, Cara N AU - Reed, William R AU - Joy, Gerald J AU - Colinet, Jay F AU - Rider, James P AU - Petsonk, Edward L AU - Abraham, Jerrold L AU - Wolfe, Anita L AU - Storey, Eileen AU - Laney, A Scott AD - Surveillance Branch, Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WVa, challdin@cdc.gov Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 62 EP - 67 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 57 IS - 1 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Historical account KW - Dust clouds KW - Occupational safety KW - Pneumoconiosis KW - Respiratory diseases KW - Coal KW - Particulates KW - Dust KW - Silica KW - Lung KW - Reviews KW - Aluminum KW - Blasting KW - Mining KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660394415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Debilitating+Lung+Disease+Among+Surface+Coal+Miners+With+No+Underground+Mining+Tenure&rft.au=Halldin%2C+Cara+N%3BReed%2C+William+R%3BJoy%2C+Gerald+J%3BColinet%2C+Jay+F%3BRider%2C+James+P%3BPetsonk%2C+Edward+L%3BAbraham%2C+Jerrold+L%3BWolfe%2C+Anita+L%3BStorey%2C+Eileen%3BLaney%2C+A+Scott&rft.aulast=Halldin&rft.aufirst=Cara&rft.date=2015-01-01&rft.volume=57&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000302 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Historical account; Occupational safety; Dust clouds; Pneumoconiosis; Particulates; Coal; Respiratory diseases; Dust; Silica; Lung; Reviews; Aluminum; Blasting; Mining DO - http://dx.doi.org/10.1097/JOM.0000000000000302 ER - TY - JOUR T1 - Rapid Identification of Major Escherichia coli Sequence Types Causing Urinary Tract and Bloodstream Infections AN - 1660393233; 21328475 AB - Escherichia coli sequence types (STs) 69, 73, 95, and 131 are collectively responsible for a large proportion of E. coli urinary tract and bloodstream infections, and they differ markedly in their antibiotic susceptibilities. Here, we describe a novel PCR method to rapidly detect and distinguish these lineages. Three hundred eighteen published E. coli genomes were compared in order to identify signature sequences unique to each of the four major STs. The specificities of these sequences were assessed in silico by seeking them in an additional 98 genomes. A PCR assay was designed to amplify size-distinguishable fragments unique to the four lineages and was validated using 515 E. coli isolates of known STs. Genome comparisons identified 22 regions ranging in size from 335 bp to 26.5 kb that are unique to one or more of the four predominant E. coli STs, with two to 10 specific regions per ST. These regions predominantly harbor genes encoding hypothetical proteins and are within or adjacent to prophage sequences. Most (13/22) were highly conserved (>96.5% identity) in the genomes of their respective ST. The new assay correctly identified all 142 representatives of the four major STs in the validation set (n = 515), with only two ST12 isolates misidentified as ST95. Compared with MLST, the assay has 100% sensitivity and 99.5% specificity. The rapid identification of major extraintestinal E. coli STs will benefit future epidemiological studies and could be developed to tailor antibiotic therapy to the different susceptibilities of these dominant lineages. JF - Journal of Clinical Microbiology AU - Doumith, M AU - Day, M AU - Ciesielczuk, H AU - Hope, R AU - Underwood, A AU - Reynolds, R AU - Wain, J AU - Livermore, D M AU - Woodford, N AD - Public Health England, London, United Kingdom, michel.doumith@phe.gov.uk. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 160 EP - 166 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 53 IS - 1 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Genomes KW - Escherichia coli KW - Polymerase chain reaction KW - Antibiotics KW - Urinary tract KW - Infection KW - Prophages KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660393233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Rapid+Identification+of+Major+Escherichia+coli+Sequence+Types+Causing+Urinary+Tract+and+Bloodstream+Infections&rft.au=Doumith%2C+M%3BDay%2C+M%3BCiesielczuk%2C+H%3BHope%2C+R%3BUnderwood%2C+A%3BReynolds%2C+R%3BWain%2C+J%3BLivermore%2C+D+M%3BWoodford%2C+N&rft.aulast=Doumith&rft.aufirst=M&rft.date=2015-01-01&rft.volume=53&rft.issue=1&rft.spage=160&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.02562-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 24 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Genomes; Polymerase chain reaction; Antibiotics; Urinary tract; Infection; Prophages; Escherichia coli DO - http://dx.doi.org/10.1128/JCM.02562-14 ER - TY - JOUR T1 - Bioaccumulation of hepatotoxins - A considerable risk in the Latvian environment AN - 1660068136; 21291133 AB - The Gulf of Riga, river Daugava and several interconnected lakes around the City of Riga, Latvia, form a dynamic brackish-freshwater system favouring occurrence of toxic cyanobacteria. We examined bioaccumulation of microcystins and nodularin-R in aquatic organisms in Latvian lakes, the Gulf of Riga and west coast of open Baltic Sea in 2002-2007. The freshwater unionids accumulated toxins efficiently, followed by snails. In contrast, Dreissena polymorpha and most lake fishes (except roach) accumulated much less hepatotoxins. Significant nodularin-R concentrations were detected also in marine clams and flounders. No transfer of nodularin-R and microcystins between lake and brackish water systems took place. Lake mussels can transfer hepatotoxins to higher organisms, and also effectively remove toxins from the water column. Obvious health risks to aquatic organisms and humans are discussed. JF - Environmental Pollution AU - Barda, Ieva AU - Kankaanpaeae, Harri AU - Purina, Ingrida AU - Balode, Maija AU - Sjovall, Olli AU - Meriluoto, Jussi AD - Latvian Institute of Aquatic Ecology, 8 Daugavgrivas Str., LV-1048 Riga, Latvia PY - 2015 SP - 313 EP - 320 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 196 SN - 0269-7491, 0269-7491 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Hepatotoxins KW - Bioaccumulation KW - Invertebrates KW - Fish KW - Health risks KW - Risk KW - Organisms KW - Lakes KW - Dynamical systems KW - Gulfs KW - Toxins KW - Dynamics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660068136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Pollution&rft.atitle=Bioaccumulation+of+hepatotoxins+-+A+considerable+risk+in+the+Latvian+environment&rft.au=Barda%2C+Ieva%3BKankaanpaeae%2C+Harri%3BPurina%2C+Ingrida%3BBalode%2C+Maija%3BSjovall%2C+Olli%3BMeriluoto%2C+Jussi&rft.aulast=Barda&rft.aufirst=Ieva&rft.date=2015-01-01&rft.volume=196&rft.issue=&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Environmental+Pollution&rft.issn=02697491&rft_id=info:doi/10.1016%2Fj.envpol.2014.10.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-02-03 DO - http://dx.doi.org/10.1016/j.envpol.2014.10.024 ER - TY - JOUR T1 - Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis AN - 1654695724; PQ0001055049 AB - The tyrosine kinase inhibitor regorafenib was approved by regulatory agencies for cancer treatment, albeit with strong warnings of severe hepatotoxicity included in the product label. The basis of this toxicity is unknown; one possible mechanism, that of mitochondrial damage, was tested. In isolated rat liver mitochondria, regorafenib directly uncoupled oxidative phosphorylation (OXPHOS) and promoted calcium overload-induced swelling, which were respectively prevented by the recoupler 6-ketocholestanol (KC) and the mitochondrial permeability transition (MPT) pore blocker cyclosporine A (CsA). In primary hepatocytes, regorafenib uncoupled OXPHOS, disrupted mitochondrial inner membrane potential (MMP), and decreased cellular ATP at 1h, and triggered MPT at 3h, which was followed by necrosis but not apoptosis at 7h and 24h, all of which were abrogated by KC. The combination of the glycolysis enhancer fructose plus the mitochondrial ATPase synthase inhibitor oligomycin A abolished regorafenib induced necrosis at 7h. This effect was not seen at 24h nor with the fructose or oligomycin A separately. CsA in combination with trifluoperazine, both MPT blockers, showed similar effects. Two compensatory mechanisms, activation of AMP-activated protein kinase (AMPK) to ameliorate ATP shortage and induction of autophagy to remove dysfunctional mitochondria, were found to be mobilized. Hepatocyte necrosis was enhanced either by the AMPK inhibitor Compound C or the autophagy inhibitor chloroquine, while autophagy inducer rapamycin was strongly cytoprotective. Remarkably, all toxic effects were observed at clinically-relevant concentrations of 2.5-15 mu M. These data suggest that uncoupling of OXPHOS and the resulting ATP shortage and MPT induction are the key mechanisms for regorafenib induced hepatocyte injury, and AMPK activation and autophagy induction serve as pro-survival pathways against such toxicity. JF - Toxicology AU - Weng, Zuquan AU - Luo, Yong AU - Yang, Xi AU - Greenhaw, James J AU - Li, Haibo AU - Xie, Liming AU - Mattes, William B AU - Shi, Qiang AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 10 EP - 21 PB - Elsevier B.V., P.O. Box 85 Limerick Ireland VL - 327 SN - 0300-483X, 0300-483X KW - Toxicology Abstracts KW - Regorafenib KW - Hepatotoxicity KW - Mitochondrion KW - Rat KW - Hepatocyte KW - Necrosis KW - Adenosinetriphosphatase KW - Apoptosis KW - Calcium KW - Injuries KW - Hepatocytes KW - ATP KW - Mitochondria KW - Membrane permeability KW - Chloroquine KW - Trifluoperazine KW - Toxicity KW - Cyclosporins KW - oligomycin A KW - Inner membranes KW - Fructose KW - AMP-activated protein kinase KW - Phagocytosis KW - Rapamycin KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654695724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Regorafenib+impairs+mitochondrial+functions%2C+activates+AMP-activated+protein+kinase%2C+induces+autophagy%2C+and+causes+rat+hepatocyte+necrosis&rft.au=Weng%2C+Zuquan%3BLuo%2C+Yong%3BYang%2C+Xi%3BGreenhaw%2C+James+J%3BLi%2C+Haibo%3BXie%2C+Liming%3BMattes%2C+William+B%3BShi%2C+Qiang&rft.aulast=Weng&rft.aufirst=Zuquan&rft.date=2015-01-01&rft.volume=327&rft.issue=&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2014.11.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 47 N1 - Last updated - 2016-07-07 N1 - SubjectsTermNotLitGenreText - Calcium; Apoptosis; Adenosinetriphosphatase; Injuries; Hepatocytes; Chloroquine; Membrane permeability; Mitochondria; ATP; Trifluoperazine; Toxicity; Cyclosporins; oligomycin A; Necrosis; Inner membranes; Fructose; AMP-activated protein kinase; Phagocytosis; Rapamycin DO - http://dx.doi.org/10.1016/j.tox.2014.11.002 ER - TY - JOUR T1 - Aerosolization of Respirable Droplets from a Domestic Spa Pool and the Use of MS-2 Coliphage and Pseudomonas aeruginosa as Markers for Legionella pneumophila AN - 1654695341; 21328329 AB - Legionnaires' disease can result when droplets or aerosols containing legionella bacteria are inhaled and deposited in the lungs. A number of outbreaks have been associated with the use of a spa pool where aeration, a high water temperature, and a large and variable organic load make disinfectant levels difficult to maintain. Spa pool ownership is increasing, and the aim of this study, using two surrogate organisms (MS-2 coliphage and Pseudomonas aeruginosa [a natural contaminant]), was to assess the potential risk to domestic users when disinfection fails. A representative "entry level" domestic spa pool was installed in an outdoor courtyard. The manufacturer's instructions for spa pool maintenance were not followed. A cyclone sampler was used to sample the aerosols released from the spa pool with and without activation of the air injection system. Samples were taken at increasing heights and distances from the pool. An aerodynamic particle sizer was used to measure the water droplet size distribution at each sample point. When the air injection system was inactivated, neither surrogate organism was recovered from the air. On activation of the air injection system, the mean mass of droplets within the respirable range (10 cm above the water line) was 36.8 mu g cm-3. This corresponded to a mean air concentration of P. aeruginosa of 350 CFU m-3. From extrapolation from animal data, the estimated risk of infection from aerosols contaminated with similar concentrations of Legionella pneumophila was 0.76 (males) and 0.65 (females). At 1 m above and/or beyond the pool, the mean aerosol mass decreased to 0.04 mu g cm-3 and corresponded to a 100-fold reduction in mean microbial air concentration. The estimated risk of infection at this distance was negligible. JF - Applied and Environmental Microbiology AU - Moore, Ginny AU - Hewitt, Matthew AU - Stevenson, David AU - Walker, Jimmy T AU - Bennett, Allan M PY - 2015 SP - 555 EP - 561 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 81 IS - 2 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cyclones KW - Legionella pneumophila KW - Disinfection KW - Aerosols KW - Data processing KW - Water temperature KW - Infection KW - Aeration KW - Samplers KW - Disinfectants KW - Injection systems KW - Colony-forming cells KW - Pseudomonas aeruginosa KW - Contaminants KW - Size distribution KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654695341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Aerosolization+of+Respirable+Droplets+from+a+Domestic+Spa+Pool+and+the+Use+of+MS-2+Coliphage+and+Pseudomonas+aeruginosa+as+Markers+for+Legionella+pneumophila&rft.au=Moore%2C+Ginny%3BHewitt%2C+Matthew%3BStevenson%2C+David%3BWalker%2C+Jimmy+T%3BBennett%2C+Allan+M&rft.aulast=Moore&rft.aufirst=Ginny&rft.date=2015-01-01&rft.volume=81&rft.issue=2&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02912-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 35 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Cyclones; Disinfection; Aerosols; Data processing; Water temperature; Infection; Samplers; Aeration; Injection systems; Disinfectants; Colony-forming cells; Contaminants; Size distribution; Legionella pneumophila; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1128/AEM.02912-14 ER - TY - JOUR T1 - Antibiotic Use before Chlamydia and Gonorrhea Genital and Extragenital Screening in the Sexually Transmitted Infection Clinical Setting AN - 1654694134; 21328160 AB - Background antibiotic use (i.e., administration of antibiotics not directly related to Chlamydia trachomatis or Neisseria gonorrhoeae infections) has been associated with a lower prevalence of genital C. trachomatis infection in a clinical setting. Associations with specific antibiotic types or with N. gonorrhoeae are lacking. Here, we assessed the prevalence of antibiotic use, the different classes and agents used, and their association with a subsequent sexually transmitted infection (STI) clinic C. trachomatis and N. gonorrhoeae test result. At our STI clinic, we systematically registered whether antibiotics were used in the past month (in 29% of the cases, the specific antibiotic agent was named). Patients were screened for urogenital C. trachomatis and N. gonorrhoeae; a third of them were also screened for anorectal and oropharyngeal C. trachomatis and N. gonorrhoeae. The proportion of antibiotics used and their association with C. trachomatis and N. gonorrhoeae prevalence were assessed for heterosexual men, men who have sex with men (MSM), and women. During 14,775 clinic consultations, antibiotic use was reported by 12.2% (95% confidence interval [CI], 11.7% to 12.7%), i.e., 14.8% of women, 8.6% of heterosexual men, and 11.6% of MSM. The most reported antibiotics were penicillins, tetracyclines, and macrolides, respectively. The prevalence was 11.0% (95% CI, 10.3% to 11.3%) for C. trachomatis and 1.9% (95% CI, 1.7% to 2.1%) for N. gonorrhoeae. Only tetracycline use was associated with a lower C. trachomatis prevalence (3%). Overall antibiotic use was associated with lower anorectal C. trachomatis prevalence in MSM only (odds ratio, 0.4; 95% CI, 0.2 to 0.8). STI clinic visitors commonly report recent antibiotic use. Even in a country with low antibiotic consumption, tetracycline use impacted C. trachomatis prevalence, while there was a notable absence of association with azithromycin. JF - Antimicrobial Agents & Chemotherapy AU - Dukers-Muijrers, Nicole HTM AU - van Liere, Genevieve AFS AU - Wolffs, Petra FG AU - Heijer, Casper Den AU - Werner, Marita ILS AU - Hoebe, Christian JPA AD - Department of Sexual Health, Infectious Diseases and Environmental Health, South Limburg Public Health Service, Geleen, the Netherlands, Nicole.dukers@ggdzl.nl. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 121 EP - 128 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 59 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Azithromycin KW - Chlamydia trachomatis KW - Antibiotics KW - Gonorrhea KW - Anorectal KW - Infection KW - Tetracyclines KW - Neisseria gonorrhoeae KW - Penicillin KW - Sex KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654694134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Antibiotic+Use+before+Chlamydia+and+Gonorrhea+Genital+and+Extragenital+Screening+in+the+Sexually+Transmitted+Infection+Clinical+Setting&rft.au=Dukers-Muijrers%2C+Nicole+HTM%3Bvan+Liere%2C+Genevieve+AFS%3BWolffs%2C+Petra+FG%3BHeijer%2C+Casper+Den%3BWerner%2C+Marita+ILS%3BHoebe%2C+Christian+JPA&rft.aulast=Dukers-Muijrers&rft.aufirst=Nicole&rft.date=2015-01-01&rft.volume=59&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.03932-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 23 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Azithromycin; Gonorrhea; Antibiotics; Anorectal; Tetracyclines; Infection; Penicillin; Sex; Chlamydia trachomatis; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1128/AAC.03932-14 ER - TY - JOUR T1 - Injection site infections and injuries in men who inject image- and performance-enhancing drugs: prevalence, risks factors, and healthcare seeking AN - 1654687775; 21155083 AB - People who inject drugs are vulnerable to infections and injuries at injection sites, but these have rarely been studied in those injecting image- and performance-enhancing drugs (IPEDs). This study examined the factors associated with reported symptoms of injection site infections and injuries in IPED injectors. Of the 366 male IPED injectors surveyed, 42% reported ever having redness, swelling and tenderness (36% in the preceding year), and 6.8% had ever had an abscess or open wound at an injection site. Having these symptoms was associated with a range of factors related to drug use and healthcare utilization. One sixth (17%) of those reporting redness, tenderness and swelling had ever sought treatment, as had the majority (76%) of those reporting an abscess, sore or open wound. Most common sources of advice were emergency clinics and General Practitioners. Interventions are needed to support access to appropriate injecting equipment and provide targeted harm reduction advice. JF - Epidemiology and Infection AU - Hope, V D AU - McVEIGH, J AU - Marongiu, A AU - Evans-Brown, M AU - Smith, J AU - KIMERGAaRD, A AU - Parry, J V AU - Ncube, F AD - Public Health England, London, UK, vivian.hope@phe.gov.uk Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 132 EP - 140 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 143 IS - 1 SN - 0950-2688, 0950-2688 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Injuries KW - Health care KW - Males KW - Risk factors KW - Intervention KW - Vulnerability KW - Risk reduction KW - Infection KW - Drug abuse KW - Drugs KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654687775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Injection+site+infections+and+injuries+in+men+who+inject+image-+and+performance-enhancing+drugs%3A+prevalence%2C+risks+factors%2C+and+healthcare+seeking&rft.au=Hope%2C+V+D%3BMcVEIGH%2C+J%3BMarongiu%2C+A%3BEvans-Brown%2C+M%3BSmith%2C+J%3BKIMERGAaRD%2C+A%3BParry%2C+J+V%3BNcube%2C+F&rft.aulast=Hope&rft.aufirst=V&rft.date=2015-01-01&rft.volume=143&rft.issue=1&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268814000727 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 36 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Health care; Injuries; Risk factors; Males; Intervention; Risk reduction; Vulnerability; Drug abuse; Infection; Drugs DO - http://dx.doi.org/10.1017/S0950268814000727 ER - TY - JOUR T1 - Age and sex differences in kidney microRNA expression during the life span of F344 rats. AN - 1652460403; 25653823 AB - Growing evidence suggests that epigenetic mechanisms of gene regulation may play a role in susceptibilities to specific toxicities and adverse drug reactions. MiRNAs in particular have been shown to be important regulators in cancer and other diseases and show promise as predictive biomarkers for diagnosis and prognosis. In this study, we characterized the global kidney miRNA expression profile in untreated male and female F344 rats throughout the life span. These findings were correlated with sex-specific susceptibilities to adverse renal events, such as male-biased renal fibrosis and inflammation in old age. Kidney miRNA expression was examined in F344 rats at 2, 5, 6, 8, 15, 21, 78, and 104 weeks of age in both sexes using Agilent miRNA microarrays. Differential expression was determined using filtering criteria of ≥1.5 fold change and ANOVA or pairwise t-test (FDR <5%) to determine significant age and sex effects, respectively. Pathway analysis software was used to investigate the possible roles of these target genes in age- and sex-specific differences. Three hundred eleven miRNAs were found to be expressed in at least one age and sex. Filtering criteria revealed 174 differentially expressed miRNAs in the kidney; 173 and 34 miRNAs exhibiting age and sex effects, respectively. Principal component analysis revealed age effects predominated over sex effects, with 2-week miRNA expression being much different from other ages. No significant sexually dimorphic miRNA expression was observed from 5 to 8 weeks, while the most differential expression (13 miRNAs) was observed at 21 weeks. Potential target genes of these differentially expressed miRNAs were identified. The expression of 56% of detected renal miRNAs was found to vary significantly with age and/or sex during the life span of F344 rats. Pathway analysis suggested that 2-week-expressed miRNAs may be related to organ and cellular development and proliferation pathways. Male-biased miRNA expression at older ages correlated with male-biased renal fibrosis and mononuclear cell infiltration. These miRNAs showed high representation in renal inflammation and nephritis pathways, and included miR-214, miR-130b, miR-150, miR-223, miR-142-5p, miR-185, and miR-296*. Analysis of kidney miRNA expression throughout the rat life span will improve the use of current and future renal biomarkers and inform our assessments of kidney injury and disease. JF - Biology of sex differences AU - Kwekel, Joshua C AU - Vijay, Vikrant AU - Desai, Varsha G AU - Moland, Carrie L AU - Fuscoe, James C AD - Division of Systems Biology, Personalized Medicine Branch, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 6 IS - 1 KW - Renal fibrosis KW - Age KW - miRNA expression KW - Kidney KW - Biomarker KW - Renal inflammation KW - Sex UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652460403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+sex+differences&rft.atitle=Age+and+sex+differences+in+kidney+microRNA+expression+during+the+life+span+of+F344+rats.&rft.au=Kwekel%2C+Joshua+C%3BVijay%2C+Vikrant%3BDesai%2C+Varsha+G%3BMoland%2C+Carrie+L%3BFuscoe%2C+James+C&rft.aulast=Kwekel&rft.aufirst=Joshua&rft.date=2015-01-01&rft.volume=6&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Biology+of+sex+differences&rft.issn=&rft_id=info:doi/10.1186%2Fs13293-014-0019-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-05 N1 - Date created - 2015-02-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1186/s13293-014-0019-1 ER - TY - JOUR T1 - Ten-year retrospective assessment of the performance of the Food Contact Notification (FCN) programme. AN - 1652444275; 25529924 AB - The Food Contact Notification (FCN) programme was authorised by the US Food and Drug Administration (USFDA) Modernization Act of 1997. Manufacturers may file FCNs for food contact substances (FCSs) not already authorised or pre-sanctioned by the USFDA by demonstrating a reasonable certainty of no harm for their intended uses. The Division of Food Contact Notifications (DFCN) 10-year Retrospective Assessment Group was formed to collect and develop metrics associated with the first decade of the FCN Programme and determine the extent selected aspects of the review process contributed to the effective FCN. Comparative analysis of 924 FCNs revealed that 76% become effective, 23% were withdrawn and 1% received a not accepted status. The focus of the Group was to identify factors impacting the likelihood of an FCN becoming effective. JF - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment AU - Neal-Kluever, April AU - Cooper, Jessica AU - Zebovitz, Thomas C AU - Butts, Kyla M AD - a US Food and Drug Administration, Center for Food Safety and Applied Nutrition , Division of Food Contact Notifications , College Park , MD , USA. Y1 - 2015 PY - 2015 DA - 2015 SP - 261 EP - 270 VL - 32 IS - 2 KW - Index Medicus KW - regulatory toxicology KW - regulatory chemistry KW - food contact KW - health policy KW - safety assessment KW - United States KW - Retrospective Studies KW - United States Food and Drug Administration KW - Food Analysis KW - Food Contamination -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652444275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.atitle=Ten-year+retrospective+assessment+of+the+performance+of+the+Food+Contact+Notification+%28FCN%29+programme.&rft.au=Neal-Kluever%2C+April%3BCooper%2C+Jessica%3BZebovitz%2C+Thomas+C%3BButts%2C+Kyla+M&rft.aulast=Neal-Kluever&rft.aufirst=April&rft.date=2015-01-01&rft.volume=32&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.issn=1944-0057&rft_id=info:doi/10.1080%2F19440049.2014.994112 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-23 N1 - Date created - 2015-01-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/19440049.2014.994112 ER - TY - JOUR T1 - Sexual dimorphism in the expression of mitochondria-related genes in rat heart at different ages. AN - 1652419542; 25615628 AB - Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Moreover, sex and age are considered major risk factors in the development of CVDs. Mitochondria are vital for normal cardiac function, and regulation of mitochondrial structure and function may impact susceptibility to CVD. To identify potential role of mitochondria in sex-related differences in susceptibility to CVD, we analyzed the basal expression levels of mitochondria-related genes in the hearts of male and female rats. Whole genome expression profiling was performed in the hearts of young (8-week), adult (21-week), and old (78-week) male and female Fischer 344 rats and the expression of 670 unique genes related to various mitochondrial functions was analyzed. A significant (p<0.05) sexual dimorphism in expression levels of 46, 114, and 41 genes was observed in young, adult and old rats, respectively. Gene Ontology analysis revealed the influence of sex on various biological pathways related to cardiac energy metabolism at different ages. The expression of genes involved in fatty acid metabolism was significantly different between the sexes in young and adult rat hearts. Adult male rats also showed higher expression of genes associated with the pyruvate dehydrogenase complex compared to females. In young and adult hearts, sexual dimorphism was not noted in genes encoding oxidative phosphorylation. In old rats, however, a majority of genes involved in oxidative phosphorylation had higher expression in females compared to males. Such basal differences between the sexes in cardiac expression of genes associated with energy metabolism may indicate a likely involvement of mitochondria in susceptibility to CVDs. In addition, female rats showed lower expression levels of apoptotic genes in hearts compared to males at all ages, which may have implications for better preservation of cardiac mass in females than in males. JF - PloS one AU - Vijay, Vikrant AU - Han, Tao AU - Moland, Carrie L AU - Kwekel, Joshua C AU - Fuscoe, James C AU - Desai, Varsha G AD - Personalized Medicine Branch, Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America. Y1 - 2015 PY - 2015 DA - 2015 SP - 1 VL - 10 IS - 1 KW - Mitochondrial Proteins KW - 0 KW - Index Medicus KW - Rats KW - Gene Expression Profiling KW - Animals KW - Rats, Inbred F344 KW - Cardiovascular Diseases -- etiology KW - Sex Characteristics KW - Genome, Mitochondrial KW - Gene Expression Regulation KW - Male KW - Female KW - Mitochondrial Proteins -- genetics KW - Mitochondria, Heart -- genetics KW - Energy Metabolism KW - Heart -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652419542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Sexual+dimorphism+in+the+expression+of+mitochondria-related+genes+in+rat+heart+at+different+ages.&rft.au=Vijay%2C+Vikrant%3BHan%2C+Tao%3BMoland%2C+Carrie+L%3BKwekel%2C+Joshua+C%3BFuscoe%2C+James+C%3BDesai%2C+Varsha+G&rft.aulast=Vijay&rft.aufirst=Vikrant&rft.date=2015-01-01&rft.volume=10&rft.issue=1&rft.spage=e0117047&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/10.1371%2Fjournal.pone.0117047 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2016-01-04 N1 - Date created - 2015-01-24 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Med. 2011 May-Jun;17(5-6):542-9 [21193900] Congest Heart Fail. 2011 Nov-Dec;17(6):255-6 [22103916] Gynecol Endocrinol. 2012 Sep;28(9):746-51 [22329808] Handb Exp Pharmacol. 2012;(214):23-48 [23027444] Gen Physiol Biophys. 2013 Sep;32(3):415-20 [23817642] Am Heart J. 2000 Feb;139(2 Pt 3):S70-85 [10650320] Mol Cell Biol. 2000 Apr;20(8):2890-901 [10733592] Mol Cell Biochem. 2000 Dec;215(1-2):21-30 [11204452] Adv Enzyme Regul. 2001;41:269-88 [11384751] Circ Res. 1991 Jun;68(6):1560-8 [2036710] Physiol Rev. 1992 Oct;72(4):881-940 [1438581] J Pediatr. 1994 Feb;124(2):224-8 [8301427] Exp Cell Res. 1995 Jul;219(1):110-21 [7628527] J Am Coll Cardiol. 1995 Oct;26(4):1068-79 [7560601] Am Heart J. 1996 Apr;131(4):704-9 [8721642] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9782-7 [8790408] N Engl J Med. 1997 Apr 17;336(16):1131-41 [9099657] Nat Genet. 1997 Jul;16(3):226-34 [9207786] Biochem Cell Biol. 1997;75(2):137-42 [9250361] Circulation. 1997 Oct 7;96(7):2468-82 [9337227] J Am Coll Cardiol. 1997 Dec;30(7):1872-7 [9385921] Science. 1999 Mar 5;283(5407):1482-8 [10066162] Semin Perinatol. 1999 Apr;23(2):125-51 [10331465] J Mol Cell Cardiol. 2004 Nov;37(5):921-9 [15522269] J Clin Invest. 2005 Mar;115(3):547-55 [15765136] Free Radic Biol Med. 2005 May 15;38(10):1278-95 [15855047] Science. 2005 Jun 10;308(5728):1583-7 [15947175] Can J Physiol Pharmacol. 2006 Jan;84(1):93-109 [16845894] Exp Gerontol. 2007 Mar;42(3):173-82 [17118599] Comp Biochem Physiol A Mol Integr Physiol. 2007 Jan;146(1):26-39 [17081788] Ann Med. 2007;39(1):28-41 [17364449] Cardiovasc Res. 2007 Jun 1;74(3):456-65 [17376413] Respir Physiol Neurobiol. 2007 Sep 30;158(2-3):224-36 [17442631] BMC Bioinformatics. 2008;9 Suppl 9:S20 [18793466] J Clin Invest. 1988 Dec;82(6):2017-25 [3198763] N Engl J Med. 1990 May 31;322(22):1561-6 [2139921] Eur Heart J. 1990 Jun;11(6):509-16 [2161769] Womens Health (Lond Engl). 2010 Sep;6(5):737-52 [20887171] Pediatr Res. 1990 Dec;28(6):657-62 [2284166] J Cell Biochem. 2008 Dec 15;105(6):1342-51 [18846505] Mitochondrion. 2009 Feb;9(1):9-16 [18824140] Mitochondrion. 2009 Apr;9(2):149-58 [19460291] Toxicol Appl Pharmacol. 2009 Jul 15;238(2):150-9 [19442681] Annu Rev Physiol. 2009;71:1-18 [18828746] Methods Mol Biol. 2009;563:379-98 [19597796] Exp Biol Med (Maywood). 2009 Sep;234(9):1011-9 [19546346] BMC Bioinformatics. 2006;7 Suppl 2:S11 [17118132] Circ J. 2010 Jul;74(7):1265-73 [20558892] Nat Rev Mol Cell Biol. 2010 Sep;11(9):655-67 [20729931] Nat Commun. 2014;5:3230 [24510058] Philos Trans R Soc Lond B Biol Sci. 2014 Jul 5;369(1646):20130446 [24864314] J Clin Invest. 2001 Jun;107(11):1403-9 [11390422] J Mol Cell Cardiol. 2001 Jun;33(6):1065-89 [11444914] Methods. 2001 Dec;25(4):402-8 [11846609] Heart Fail Rev. 2002 Apr;7(2):115-30 [11988636] Ann N Y Acad Sci. 2004 Apr;1011:86-100 [15126287] Cardiovasc Res. 2004 Aug 15;63(3):510-9 [15276476] J Mol Cell Cardiol. 2004 Aug;37(2):507-13 [15276020] Biochem Soc Trans. 2004 Dec;32(Pt 6):1021-4 [15506953] J Natl Cancer Inst. 1975 Jun;54(6):1449-56 [1133852] Biochem J. 1980 Nov 1;191(2):421-7 [6263247] BMC Genomics. 2010;11:675 [21118493] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pone.0117047 ER - TY - JOUR T1 - The relationship between elemental carbon and diesel particulate matter in underground metal/nonmetal mines in the United States and coal mines in Australia. AN - 1652396689; 25380085 AB - In the United States, total carbon (TC) is used as a surrogate for determining diesel particulate matter (DPM) compliance exposures in underground metal/nonmetal mines. Since TC can be affected by interferences and elemental carbon (EC) is not, one method used to estimate the TC concentration is to multiply the EC concentration from the personal sample by a conversion factor to avoid the influence of potential interferences. Since there is no accepted single conversion factor for all metal/nonmetal mines, one is determined every time an exposure sample is taken by collecting an area sample that represents the TC/EC ratio in the miner's breathing zone and is away from potential interferences. As an alternative to this procedure, this article investigates the relationship between TC and EC from DPM samples to determine if a single conversion factor can be used for all metal/nonmetal mines. In addition, this article also investigates how well EC represents DPM concentrations in Australian coal mines since the recommended exposure limit for DPM in Australia is an EC value. When TC was predicted from EC values using a single conversion factor of 1.27 in 14 US metal/nonmetal mines, 95% of the predicted values were within 18% of the measured value, even at the permissible exposure limit (PEL) concentration of 160 μg/m(3) TC. A strong correlation between TC and EC was also found in nine underground coal mines in Australia. JF - Journal of occupational and environmental hygiene AU - Noll, James AU - Gilles, Stewart AU - Wu, Hsin Wei AU - Rubinstein, Elaine AD - a Dust, Ventilation and Toxic Substance Branch, U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health , Pittsburgh Research Laboratory , Pittsburgh , Pennsylvania. Y1 - 2015 PY - 2015 DA - 2015 SP - 205 EP - 211 VL - 12 IS - 3 KW - Air Pollutants, Occupational KW - 0 KW - Particulate Matter KW - Vehicle Emissions KW - Carbon KW - 7440-44-0 KW - Index Medicus KW - diesel KW - elemental carbon KW - measurement KW - United States KW - Australia KW - Occupational Exposure -- analysis KW - Environmental Monitoring -- methods KW - Air Pollutants, Occupational -- analysis KW - Mining KW - Carbon -- analysis KW - Particulate Matter -- analysis KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652396689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+occupational+and+environmental+hygiene&rft.atitle=The+relationship+between+elemental+carbon+and+diesel+particulate+matter+in+underground+metal%2Fnonmetal+mines+in+the+United+States+and+coal+mines+in+Australia.&rft.au=Noll%2C+James%3BGilles%2C+Stewart%3BWu%2C+Hsin+Wei%3BRubinstein%2C+Elaine&rft.aulast=Noll&rft.aufirst=James&rft.date=2015-01-01&rft.volume=12&rft.issue=3&rft.spage=205&rft.isbn=&rft.btitle=&rft.title=Journal+of+occupational+and+environmental+hygiene&rft.issn=1545-9632&rft_id=info:doi/10.1080%2F15459624.2014.960577 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-19 N1 - Date created - 2015-01-14 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Environ Monit. 2004 Oct;6(10):799-806 [15480493] Analyst. 1996 Sep;121(9):1183-90 [8831275] Environ Sci Technol. 2008 Jul 15;42(14):5223-8 [18756633] J Occup Environ Hyg. 2005 Jan;2(1):29-37 [15764521] Environ Sci Technol. 2007 Feb 1;41(3):710-6 [17333567] J Environ Monit. 2004 Dec;6(12):973-8 [15568046] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/15459624.2014.960577 ER - TY - JOUR T1 - Non-smoker exposure to secondhand cannabis smoke. I. Urine screening and confirmation results. AN - 1652376881; 25326203 AB - Increased cannabis potency has renewed concerns that secondhand exposure to cannabis smoke can produce positive drug tests. A systematic study was conducted of smoke exposure on drug-free participants. Six experienced cannabis users smoked cannabis cigarettes (5.3% THC in Session 1 and 11.3% THC in Sessions 2 and 3) in a sealed chamber. Six non-smokers were seated with smokers in an alternating manner. Sessions 1 and 2 were conducted with no ventilation and ventilation was employed in Session 3. Non-smoking participant specimens (collected 0-34 h) were analyzed with four immunoassays at different cutoff concentrations (20, 50, 75 and 100 ng/mL) and by GC-MS (LOQ = 0.75 ng/mL). No presumptive positives occurred for non-smokers at 100 and 75 ng/mL; a single positive occurred at 50 ng/mL; and multiple positives occurred at 20 ng/mL. Maximum THCCOOH concentrations by GC-MS for non-smokers ranged from 1.3 to 57.5 ng/mL. THCCOOH concentrations generally increased with THC potency, but room ventilation substantially reduced exposure levels. These results demonstrate that extreme cannabis smoke exposure can produce positive urine tests at commonly utilized cutoff concentrations. However, positive tests are likely to be rare, limited to the hours immediately post-exposure, and occur only under environmental circumstances where exposure is obvious. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Journal of analytical toxicology AU - Cone, Edward J AU - Bigelow, George E AU - Herrmann, Evan S AU - Mitchell, John M AU - LoDico, Charles AU - Flegel, Ronald AU - Vandrey, Ryan AD - Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA edwardjcone@gmail.com. ; Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; RTI International, Research Triangle Park, NC, USA. ; Division of Workplace Programs (DWP), Substance Abuse and Mental Health Services Administration (SAMHSA), Rockville, MD, USA. PY - 2015 SP - 1 EP - 12 VL - 39 IS - 1 KW - Tobacco Smoke Pollution KW - 0 KW - Dronabinol KW - 7J8897W37S KW - Index Medicus KW - Sensitivity and Specificity KW - Young Adult KW - Humans KW - Adult KW - Specimen Handling KW - Gas Chromatography-Mass Spectrometry KW - Urinalysis KW - Male KW - Female KW - Dronabinol -- urine KW - Cannabis -- chemistry KW - Tobacco Smoke Pollution -- adverse effects KW - Smoking -- adverse effects KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1652376881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Non-smoker+exposure+to+secondhand+cannabis+smoke.+I.+Urine+screening+and+confirmation+results.&rft.au=Cone%2C+Edward+J%3BBigelow%2C+George+E%3BHerrmann%2C+Evan+S%3BMitchell%2C+John+M%3BLoDico%2C+Charles%3BFlegel%2C+Ronald%3BVandrey%2C+Ryan&rft.aulast=Cone&rft.aufirst=Edward&rft.date=2015-01-01&rft.volume=39&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbku116 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-06 N1 - Date created - 2015-01-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Forensic Sci. 2000 Jan;45(1):24-30 [10641915] PLoS One. 2013;8(7):e70052 [23894589] Clin Pharmacol Ther. 1983 Jul;34(1):36-41 [6305545] J Anal Toxicol. 1983 Jul-Aug;7(4):172-4 [6314043] J Pharm Pharmacol. 1984 May;36(5):289-94 [6145762] J Pharm Pharmacol. 1984 Sep;36(9):578-81 [6149279] J Forensic Sci. 1985 Oct;30(4):997-1002 [2999292] Clin Pharmacol Ther. 1986 Sep;40(3):247-56 [3017628] Arch Kriminol. 1987 Jan-Feb;179(1-2):31-7 [3551865] J Anal Toxicol. 1987 May-Jun;11(3):89-96 [3037193] J Anal Toxicol. 1988 May-Jun;12(3):113-6 [3386204] Forensic Sci Int. 2008 Jan 30;174(2-3):111-9 [17434274] J Anal Toxicol. 2005 Oct;29(7):607-15 [16419389] J Anal Toxicol. 1992 Jul-Aug;16(4):228-35 [1323733] Br J Psychiatry. 2009 Dec;195(6):488-91 [19949195] J Anal Toxicol. 2010 May;34(4):196-203 [20465865] Neuropsychopharmacology. 2010 Aug;35(9):1879-85 [20428110] Dtsch Arztebl Int. 2012 Jul;109(29-30):495-501 [23008748] Curr Pharm Des. 2012;18(32):5113-30 [22716133] Clin Pharmacokinet. 2003;42(4):327-60 [12648025] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bku116 ER - TY - JOUR T1 - Participant and site characteristics related to participant retention in a diabetes prevention translational project AN - 1648072807; 4638778 AB - Using multilevel analysis, this study investigated participant and site characteristics associated with participant retention in a multisite diabetes prevention translational project among American Indian and Alaska Native (AI/AN) people. We analyzed data from the Special Diabetes Program for Indians Diabetes Prevention Program (SDPI-DP), a lifestyle intervention to prevent diabetes implemented in 36 AI/AN grantee sites. A total of 2,553 participants were recruited and started the intervention between January 1, 2006 and July 31, 2008. They were offered the 16-session Italic Lifestyle Balance Curriculum from the Diabetes Prevention Program (DPP) in the first 16-24_weeks of intervention. Generalized estimating equation models and proportional hazards models with robust standard error estimates were used to evaluate the relationships of participant and site characteristics with retention. As of July 31, 2009, about 50_% of SDPI-DP participants were lost to follow-up. Those who were younger, male, with lower household income, no family support person, and more baseline chronic pain were at higher risk for both short-term and long-term retention failure (i.e., not completing all 16 DPP sessions and loss to follow-up, respectively). Sites with large user populations and younger staff had lower likelihood of retaining participants successfully. Other site characteristics related to higher risk for retention failure included staff rating of participant disinterest in SDPI-DP and barriers to participant transportation and child/elder care. Future translational initiatives need to pay attention to both participant- and site-level factors in order to maximize participant retention. Reprinted by permission of Springer JF - Prevention science AU - Jiang, Luohua AU - Manson, Spero M AU - Dill, Edward J AU - Beals, Janette AU - Johnson, Ann AU - Huang, Haixiao AU - Acton, Kelly J AU - Roubideaux, Yvette AD - Texas A&M University ; University of Colorado ; US Department of Health and Human Services Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 41 EP - 52 VL - 16 IS - 1 SN - 1389-4986, 1389-4986 KW - Sociology KW - Indians KW - Prevention KW - U.S.A. KW - Life styles KW - Risk theory KW - Public health KW - Dropouts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1648072807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prevention+science&rft.atitle=Participant+and+site+characteristics+related+to+participant+retention+in+a+diabetes+prevention+translational+project&rft.au=Jiang%2C+Luohua%3BManson%2C+Spero+M%3BDill%2C+Edward+J%3BBeals%2C+Janette%3BJohnson%2C+Ann%3BHuang%2C+Haixiao%3BActon%2C+Kelly+J%3BRoubideaux%2C+Yvette&rft.aulast=Jiang&rft.aufirst=Luohua&rft.date=2015-01-01&rft.volume=16&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Prevention+science&rft.issn=13894986&rft_id=info:doi/10.1007%2Fs11121-013-0451-1 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-01-26 N1 - Last updated - 2015-01-26 N1 - SubjectsTermNotLitGenreText - 3739 7684; 10072; 6301 1335 4424; 10449 5772; 7404; 11040 11035; 433 293 14 DO - http://dx.doi.org/10.1007/s11121-013-0451-1 ER - TY - JOUR T1 - Real-time PCR detection of Listeria monocytogenes in infant formula and lettuce following macrophage-based isolation and enrichment AN - 1647021295; 21232041 AB - To develop a rapid detection procedure for Listeria monocytogenes in infant formula and lettuce using a macrophage-based enrichment protocol and real-time PCR. A macrophage cell culture system was employed for the isolation and enrichment of L. monocytogenes from infant formula and lettuce for subsequent identification using real-time PCR. Macrophage monolayers were exposed to infant formula and lettuce contaminated with a serial dilution series of L. monocytogenes. As few as approx. 10 CFU ml-1 or g-1 of L. monocytogenes were detected in infant formula and lettuce after 16 h postinfection by real-time PCR. Internal positive PCR controls were utilized to eliminate the possibility of false-negative results. Co-inoculation with Listeria innocua did not reduce the L. monocytogenes detection sensitivity. Intracellular L. monocytogenes could also be isolated on Listeria selective media from infected macrophage lysates for subsequent confirmation. The detection method is highly sensitive and specific for L. monocytogenes in infant formula and lettuce and establishes a rapid identification time of 20 and 48 h for presumptive and confirmatory identification, respectively. The method is a promising alternative to many currently used q-PCR detection methods which employ traditional selective media for enrichment of contaminated food samples. Macrophage enrichment of L. monocytogenes eliminates PCR inhibitory food elements and contaminating food microflora which produce cleaner samples that increase the rapidity and sensitivity of detection. JF - Journal of Applied Microbiology AU - Day, J B AU - Basavanna, U AD - U.S. Food and Drug Administration. Center for Food Safety and Applied Nutrition Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 233 EP - 244 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 118 IS - 1 SN - 1364-5072, 1364-5072 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Macrophages KW - Listeria monocytogenes KW - Infant formulas KW - Colony-forming cells KW - Listeria innocua KW - Microflora KW - Polymerase chain reaction KW - Cell culture KW - Food contamination KW - Media (selective) KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647021295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Real-time+PCR+detection+of+Listeria+monocytogenes+in+infant+formula+and+lettuce+following+macrophage-based+isolation+and+enrichment&rft.au=Day%2C+J+B%3BBasavanna%2C+U&rft.aulast=Day&rft.aufirst=J&rft.date=2015-01-01&rft.volume=118&rft.issue=1&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.12674 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Infant formulas; Colony-forming cells; Microflora; Polymerase chain reaction; Cell culture; Food contamination; Media (selective); Listeria monocytogenes; Listeria innocua DO - http://dx.doi.org/10.1111/jam.12674 ER - TY - JOUR T1 - The impact of introduced hosts on parasite transmission: opisthorchiid infections in American mink (Neovison vison) AN - 1647008727; 21314312 AB - Introduced animals may be considered at an advantage over native competitors because they have escaped natural parasites. In some cases however, generalist parasites in a novel environment can use introduced species as an alternative or reservoir host. This can change the dynamics of parasite populations, with implications for epidemiology. The key factor determining the impact of an alternative host is its ability to maintain a reproductively successful parasite and contribute to the transmission potential of that parasite. The digenean Pseudamphistomum truncatum is found in native otters Lutra lutra in Britain and has been reported in introduced American mink Neovison vison. To investigate whether introduced mink are competent hosts and to ask how mink compare with otters as hosts, we compared parasite prevalence, intensity and fecundity between the two host species in a region where both are common. Although prevalence was not statistically different between otters and mink (48 %, n = 27, compared to 33 %, n = 21 respectively), mean parasite intensity was higher in mink (253 plus or minus 145 standard error parasites/infected host, compared to 46 plus or minus 18 in otters). Parasite fecundity was lower in mink (mean egg count/parasite/host = 622 plus or minus 64) than in otters (1,204 plus or minus 108), and this difference was not confounded by host or parasite size or by intraspecific competition among parasites. Assuming the parasite eggs are equally viable from otters or mink, mink are not only a competent host for P. truncatum, but because of the higher parasite intensity in mink, they can potentially spread c.3 times as many parasite eggs to intermediate hosts, than otters. The naturalisation of mink to new habitats may therefore contribute to trematode infections in native fauna. JF - Biological Invasions AU - Sherrard-Smith, Ellie AU - Chadwick, Elizabeth A AU - Cable, Jo AD - School of Biosciences, Cardiff University, Museum Avenue, Cardiff, CF10 3AX, UK, ellie.sherrard-smith@phe.gov.uk PY - 2015 SP - 115 EP - 122 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 17 IS - 1 SN - 1387-3547, 1387-3547 KW - Sustainability Science Abstracts; Ecology Abstracts KW - Introduced animals KW - Parasites KW - Mammals KW - Infection KW - Eggs KW - Disease transmission KW - Fauna KW - Invasions KW - Reservoirs KW - Competition KW - Pseudamphistomum truncatum KW - Habitat KW - Fecundity KW - Epidemiology KW - Lutrinae KW - Introduced species KW - Lutra lutra KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647008727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Invasions&rft.atitle=The+impact+of+introduced+hosts+on+parasite+transmission%3A+opisthorchiid+infections+in+American+mink+%28Neovison+vison%29&rft.au=Sherrard-Smith%2C+Ellie%3BChadwick%2C+Elizabeth+A%3BCable%2C+Jo&rft.aulast=Sherrard-Smith&rft.aufirst=Ellie&rft.date=2015-01-01&rft.volume=17&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Biological+Invasions&rft.issn=13873547&rft_id=info:doi/10.1007%2Fs10530-014-0709-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 57 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Parasites; Fecundity; Epidemiology; Invasions; Habitat; Introduced species; Infection; Competition; Eggs; Disease transmission; Introduced animals; Fauna; Mammals; Reservoirs; Pseudamphistomum truncatum; Lutrinae; Lutra lutra DO - http://dx.doi.org/10.1007/s10530-014-0709-y ER - TY - JOUR T1 - Effects of perinatal methylphenidate (MPH) treatment on postweaning behaviors of male and female Sprague-Dawley rats. AN - 1645234020; 25514582 AB - Methylphenidate (MPH) is a common treatment for adult Attention Deficit Hyperactivity Disorder (ADHD). However, little information exists regarding its safety during pregnancy and thus, women with ADHD face difficult decisions regarding continued use during pregnancy. Thus, Sprague-Dawley rats were orally treated 3×/day with 0 (control), 6 (low), 18 (mid), or 42 (high) mg MPH/kg/day (i.e., 0, 2, 6, or 14mg/kg at each treatment time) on gestational days 6-21. All offspring/litter were orally treated with the same dose their dam had received on postnatal days (PNDs) 1-21. After weaning, offspring were assessed for adolescent play behavior, locomotor activity, motor coordination, Barnes maze performance, acoustic startle response, novel object recognition, residential running wheel activity, flavored solution intake, home cage behavior, water maze performance, elevated plus maze behavior, locomotor response to an MPH challenge, and passive avoidance. At euthanasia, whole brain and striatal weights as well as serum hormone levels were measured. Body weights of the high MPH group were reduced in both sexes. Males of the high MPH group were less active than control males in open field assessments on PNDs 40-42. Latency to maximum acoustic startle was significantly altered in females of the medium and high MPH groups and residential running wheel activity of females of the low and medium MPH groups was lower than control females. Open arm entries in the elevated plus maze were increased in subjects of the medium MPH group. Females of the low MPH group were less sensitive to the locomotor-increasing effects of an acute 5mg/kg MPH challenge. Serum hormone levels and whole brain and striatal weights were not altered by prior MPH treatment. These results indicate that MPH treatment during development has sporadic effects on postweaning behaviors and those effects were generally exhibited by females. Published by Elsevier Inc. JF - Neurotoxicology and teratology AU - Ferguson, Sherry A AU - Delbert Law, C AU - Sahin, Leyla AU - Montenegro, Susan V AD - Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address: Sherry.Ferguson@fda.hhs.gov. ; Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR 72079, United States. ; Pediatric and Maternal Health Staff, Office of New Drugs, Center for Drug Evaluation Research, Food and Drug Administration, Silver Spring, MD 20993, United States. ; Division of Epidemiology II, Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation Research, Food and Drug Administration, Silver Spring, MD 20993, United States. PY - 2015 SP - 125 EP - 136 VL - 47 KW - Central Nervous System Stimulants KW - 0 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Rat KW - Hormone KW - Behavior KW - Ritalinic acid KW - Pregnancy KW - Eating -- drug effects KW - Animals KW - Maze Learning -- drug effects KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Brain -- drug effects KW - Homing Behavior -- drug effects KW - Sensory Gating -- drug effects KW - Avoidance Learning -- drug effects KW - Rats KW - Animals, Newborn KW - Rats, Sprague-Dawley KW - Psychomotor Performance -- drug effects KW - Drinking -- drug effects KW - Exploratory Behavior -- drug effects KW - Body Weight -- drug effects KW - Motor Activity -- drug effects KW - Male KW - Female KW - Behavior, Animal -- drug effects KW - Central Nervous System Stimulants -- toxicity KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Methylphenidate -- toxicity KW - Prenatal Exposure Delayed Effects -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645234020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Effects+of+perinatal+methylphenidate+%28MPH%29+treatment+on+postweaning+behaviors+of+male+and+female+Sprague-Dawley+rats.&rft.au=Ferguson%2C+Sherry+A%3BDelbert+Law%2C+C%3BSahin%2C+Leyla%3BMontenegro%2C+Susan+V&rft.aulast=Ferguson&rft.aufirst=Sherry&rft.date=2015-01-01&rft.volume=47&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=1872-9738&rft_id=info:doi/10.1016%2Fj.ntt.2014.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-10 N1 - Date created - 2015-01-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ntt.2014.12.002 ER - TY - JOUR T1 - Gene-directed enzyme prodrug therapy. AN - 1643147736; 25338741 AB - As one targeting strategy of prodrug delivery, gene-directed enzyme prodrug therapy (GDEPT) promises to realize the targeting through its three key features in cancer therapy-cell-specific gene delivery and expression, controlled conversion of prodrugs to drugs in target cells, and expanded toxicity to the target cells' neighbors through bystander effects. After over 20 years of development, multiple GDEPT systems have advanced into clinical trials. However, no GDEPT product is currently marketed as a drug, suggesting that there are still barriers to overcome before GDEPT becomes a standard therapy. In this review, we first provide a general introduction of this prodrug targeting strategy. Then, we utilize the four most thoroughly studied systems to illustrate components, mechanisms, preclinical and clinical results, and further development directions of GDEPT. These four systems are herpes simplex virus thymidine kinase/ganciclovir, cytosine deaminase/5-fluorocytosine, cytochrome P450/oxazaphosphorines, and nitroreductase/CB1954 system. Later, we focus our discussion on bystander effects including local and distant bystander effects. Lastly, we discuss carriers that are used to deliver genes for GDEPT including virus carriers and non-virus carriers. Among these carriers, the stem cell-based gene delivery system represents one of the newest carriers under development, and may brought about a breakthrough to the gene delivery issue of GDEPT. JF - The AAPS journal AU - Zhang, Jin AU - Kale, Vijay AU - Chen, Mingnan AD - The U.S. Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, Maryland, 20993, USA, jinzhang526@gmail.com. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 102 EP - 110 VL - 17 IS - 1 KW - Enzymes KW - 0 KW - Prodrugs KW - Index Medicus KW - Animals KW - Stem Cells -- cytology KW - Gene Transfer Techniques KW - Bystander Effect KW - Humans KW - Drug Design KW - Enzymes -- genetics KW - Drug Delivery Systems KW - Genetic Therapy -- methods KW - Prodrugs -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1643147736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Gene-directed+enzyme+prodrug+therapy.&rft.au=Zhang%2C+Jin%3BKale%2C+Vijay%3BChen%2C+Mingnan&rft.aulast=Zhang&rft.aufirst=Jin&rft.date=2015-01-01&rft.volume=17&rft.issue=1&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-014-9675-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-15 N1 - Date created - 2015-01-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Mol Ther. 2007 May;15(5):1016-23 [17375076] Cancer Res. 2007 Jul 1;67(13):6304-13 [17616689] Clin Cancer Res. 2007 Oct 1;13(19):5847-54 [17908978] Cancer Res. 2007 Dec 15;67(24):11687-95 [18089798] Mol Ther. 2009 Jul;17(7):1292-9 [19367257] Curr Opin Mol Ther. 2009 Aug;11(4):421-32 [19649987] 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Clin Oncol. 2011 Sep 20;29(27):3611-9 [21844505] Scand J Gastroenterol. 1999 Oct;34(10):1033-41 [10563675] J Clin Oncol. 1999 Jul;17(7):2180-9 [10561274] J Natl Cancer Inst. 1999 Dec 1;91(23):2014-9 [10580026] Hum Gene Ther. 2000 Jan 1;11(1):77-89 [10646641] Cancer Gene Ther. 2000 Jan;7(1):20-6 [10678352] Cancer Gene Ther. 2000 Jan;7(1):74-82 [10678359] Cancer Gene Ther. 2000 Apr;7(4):557-62 [10811473] J Gene Med. 2000 May-Jun;2(3):148-64 [10894261] Cancer Gene Ther. 2000 Jul;7(7):1015-22 [10917204] Cancer Res. 2000 Aug 1;60(15):3989-99 [10945596] Oncogene. 2002 Mar 28;21(14):2141-53 [11948397] Curr Pharm Des. 2002;8(15):1349-61 [12052212] Cancer Res. 2002 Dec 1;62(23):6928-37 [12460909] Hum Gene Ther. 2003 Feb 10;14(3):227-41 [12639303] Hum Gene Ther. 2003 Mar 20;14(5):463-72 [12691611] Cancer Gene Ther. 2003 Oct;10(10):737-44 [14502226] Ann Neurol. 2003 Oct;54(4):479-87 [14520660] Cancer Res. 2003 Nov 1;63(21):7497-506 [14612551] Curr Pharm Des. 2004;10(5):531-55 [14965338] J 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Cancer Gene Ther. 1997 Mar-Apr;4(2):113-7 [9080120] Hum Gene Ther. 1997 Apr 10;8(6):709-17 [9113510] Cancer Gene Ther. 1997 Jul-Aug;4(4):246-52 [9253510] Cancer Res. 1997 Oct 1;57(19):4205-9 [9331076] Cancer Res. 1997 Oct 1;57(19):4325-32 [9331094] Endocrinology. 1997 Nov;138(11):4577-83 [9348181] Hum Gene Ther. 1997 Oct 10;8(15):1807-14 [9358030] J Natl Cancer Inst. 1998 Mar 4;90(5):370-80 [9498487] Gene Ther. 1998 Apr;5(4):507-13 [9614575] Prostate. 2000 Oct 1;45(2):149-57 [11027414] Hum Gene Ther. 2000 Nov 20;11(17):2389-401 [11096443] Nat Med. 2001 Jan;7(1):33-40 [11135613] Cancer Res. 2001 Mar 1;61(5):1805-9 [11280727] Cancer Res. 2001 Apr 1;61(7):3022-6 [11306482] Cancer Gene Ther. 2001 Mar;8(3):220-30 [11332993] Cancer Gene Ther. 2001 Jul;8(7):473-82 [11498768] Mol Pharmacol. 2001 Dec;60(6):1268-79 [11723234] Eur J Cancer. 2002 Jan;38(2):231-9 [11803140] Anticancer Res. 1998 Mar-Apr;18(2A):713-8 [9615710] Exp Cell Res. 1998 May 25;241(1):66-75 [9633514] Int J Radiat Oncol Biol Phys. 1998 Jul 1;41(4):883-7 [9652853] Cancer Res. 1998 Aug 15;58(16):3529-32 [9721854] Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8699-704 [10411938] J Urol. 1999 Sep;162(3 Pt 1):949-54 [10458414] Anticancer Res. 1999 May-Jun;19(3B):2163-5 [10472325] Oncogene. 2005 Feb 10;24(7):1231-43 [15592511] Clin Cancer Res. 2005 Feb 15;11(4):1512-20 [15746054] Cancer Gene Ther. 2005 May;12(5):497-508 [15746946] Adv Genet. 2005;54:235-55 [16096014] Cancer Gene Ther. 2005 Sep;12(9):757-68 [15832173] Toxicol In Vitro. 2006 Mar;20(2):176-86 [16293390] Cancer Gene Ther. 2007 Jan;14(1):57-65 [16874362] Mol Aspects Med. 2007 Feb;28(1):4-41 [17306358] Mol Ther. 2007 Apr;15(4):834-40 [17327829] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1208/s12248-014-9675-7 ER - TY - JOUR T1 - Development of Human Posture Simulation Method for Assessing Posture Angles and Spinal Loads AN - 1642628212; 21135917 AB - Video-based posture analysis employing a biomechanical model is gaining a growing popularity for ergonomic assessments. A human posture simulation method of estimating multiple body postural angles and spinal loads from a video record was developed to expedite ergonomic assessments. The method was evaluated by a repeated measures study design with three trunk flexion levels, two lift asymmetry levels, three viewing angles, and three trial repetitions as experimental factors. The study comprised two phases evaluating the accuracy of simulating self- and other people's lifting posture via a proxy of a computer-generated humanoid. The mean values of the accuracy of simulating self- and humanoid postures were 12 degree and 15 degree , respectively. The repeatability of the method for the same lifting condition was excellent (2 degree ). The least simulation error was associated with side viewing angle. The estimated back compressive force and moment, calculated by a three-dimensional biomechanical model, exhibited a range of 5% underestimation. The posture simulation method enables researchers to quantify simultaneously body posture angles and spinal loading variables with accuracy and precision comparable to on-screen posture-matching methods. JF - Human Factors and Ergonomics in Manufacturing AU - Lu, Ming-Lun AU - Waters, Thomas AU - Werren, Dwight AD - National Institute for Occupational Safety and Health, Taft Laboratories, Cincinnati, Ohio, USA. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 123 EP - 136 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 25 IS - 1 SN - 1090-8471, 1090-8471 KW - Health & Safety Science Abstracts KW - Simulation KW - Human factors KW - Posture KW - Lifting KW - Ergonomics KW - Biomechanics KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642628212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Factors+and+Ergonomics+in+Manufacturing&rft.atitle=Development+of+Human+Posture+Simulation+Method+for+Assessing+Posture+Angles+and+Spinal+Loads&rft.au=Lu%2C+Ming-Lun%3BWaters%2C+Thomas%3BWerren%2C+Dwight&rft.aulast=Lu&rft.aufirst=Ming-Lun&rft.date=2015-01-01&rft.volume=25&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Human+Factors+and+Ergonomics+in+Manufacturing&rft.issn=10908471&rft_id=info:doi/10.1002%2Fhfm.20534 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-02-18 N1 - SubjectsTermNotLitGenreText - Simulation; Human factors; Posture; Lifting; Biomechanics; Ergonomics DO - http://dx.doi.org/10.1002/hfm.20534 ER - TY - JOUR T1 - Characterization of cleaning and disinfecting tasks and product use among hospital occupations AN - 1642618571; 21189054 AB - Background Healthcare workers have an elevated prevalence of asthma and related symptoms associated with the use of cleaning/disinfecting products. The objective of this study was to identify and characterize cleaning/disinfecting tasks and products used among hospital occupations. Methods Workers from 14 occupations at five hospitals were monitored for 216 shifts, and work tasks and products used were recorded at five-minute intervals. The major chemical constituents of each product were identified from safety data sheets. Results Cleaning and disinfecting tasks were performed with a high frequency at least once per shift in many occupations. Medical equipment preparers, housekeepers, floor strippers/waxers, and endoscopy technicians spent on average 108-177min/shift performing cleaning/disinfecting tasks. Many occupations used products containing amines and quaternary ammonium compounds for >100min/shift. Conclusions This analysis demonstrates that many occupations besides housekeeping incur exposures to cleaning/disinfecting products, albeit for different durations and using products containing different chemicals. Am. J. Ind. Med. 58:101-111, 2015. copyright 2014 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Saito, Rena AU - Abbas Virji, M AU - Henneberger, Paul K AU - Humann, Michael J AU - LeBouf, Ryan F AU - Stanton, Marcia L AU - Liang, Xiaoming AU - Stefaniak, Aleksandr B AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia. Y1 - 2015/01// PY - 2015 DA - Jan 2015 SP - 101 EP - 111 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 58 IS - 1 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642618571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Characterization+of+cleaning+and+disinfecting+tasks+and+product+use+among+hospital+occupations&rft.au=Saito%2C+Rena%3BAbbas+Virji%2C+M%3BHenneberger%2C+Paul+K%3BHumann%2C+Michael+J%3BLeBouf%2C+Ryan+F%3BStanton%2C+Marcia+L%3BLiang%2C+Xiaoming%3BStefaniak%2C+Aleksandr+B&rft.aulast=Saito&rft.aufirst=Rena&rft.date=2015-01-01&rft.volume=58&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22393 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-01-07 DO - http://dx.doi.org/10.1002/ajim.22393 ER - TY - JOUR T1 - Integrative genomic and transcriptomic characterization of matched primary and metastatic liver and colorectal carcinoma. AN - 1641858269; 25552933 AB - Metastasis is the main cause of cancer mortality but its process remains poorly understood and thus hampers more effective treatment and improved cancer prognosis. To search for metastasis driver genes responsible for tumor spread, we integrated genomic and transcriptomic profiles of 61 matched primary tumors and distant metastases of liver or colorectal carcinoma isolated by laser-capture microdissection and assayed by array-based technologies. We found that primary tumor lesions and their matched distant metastases were largely similar at the genomic and transcriptomic levels, but substantial differences could be found between primary tumors with or without accompanying metastases. Interestingly, metastasis genes were principally tumor type and organ site-specific. Despite distinct pathway enrichment, different metastasis gene sets shared common prognostic capacity and were predictive of hepatocellular carcinoma survival in an independent cohort. Thus, the metastatic propensity is inherent to the primary tumor and the lack of general metastasis genes necessitates the development of specific treatment modalities. JF - International journal of biological sciences AU - Roessler, Stephanie AU - Lin, Guoling AU - Forgues, Marshonna AU - Budhu, Anuradha AU - Hoover, Shelley AU - Simpson, R Mark AU - Wu, Xiaolin AU - He, Ping AU - Qin, Lun-Xiu AU - Tang, Zhao-You AU - Ye, Qing-Hai AU - Wang, Xin Wei AD - 1. Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA; ; 1. Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA; ; 2. Liver Cancer Institute, Fudan University, Shanghai, China; ; 3. Laboratory of Cancer Biology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA; ; 4. Laboratory of Molecular Technology, NCI-Frederick, SAIC-Frederick, Frederick, MD 21701, USA; ; 5. Division of Hematology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. ; 2. Liver Cancer Institute, Fudan University, Shanghai, China; Y1 - 2015 PY - 2015 DA - 2015 SP - 88 EP - 98 VL - 11 IS - 1 KW - Index Medicus KW - Organ site-specific metastasis KW - Liver cancer KW - Colon cancer KW - Profiling. KW - Gene Expression Profiling KW - Comparative Genomic Hybridization KW - Humans KW - Microarray Analysis KW - Laser Capture Microdissection KW - China KW - Colorectal Neoplasms -- secondary KW - Neoplasm Metastasis -- genetics KW - Neoplasm Metastasis -- physiopathology KW - Colorectal Neoplasms -- genetics KW - Liver Neoplasms -- secondary KW - Liver Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1641858269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+biological+sciences&rft.atitle=Integrative+genomic+and+transcriptomic+characterization+of+matched+primary+and+metastatic+liver+and+colorectal+carcinoma.&rft.au=Roessler%2C+Stephanie%3BLin%2C+Guoling%3BForgues%2C+Marshonna%3BBudhu%2C+Anuradha%3BHoover%2C+Shelley%3BSimpson%2C+R+Mark%3BWu%2C+Xiaolin%3BHe%2C+Ping%3BQin%2C+Lun-Xiu%3BTang%2C+Zhao-You%3BYe%2C+Qing-Hai%3BWang%2C+Xin+Wei&rft.aulast=Roessler&rft.aufirst=Stephanie&rft.date=2015-01-01&rft.volume=11&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=International+journal+of+biological+sciences&rft.issn=1449-2288&rft_id=info:doi/10.7150%2Fijbs.10583 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-14 N1 - Date created - 2015-01-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nat Med. 2006 Aug;12(8):895-904 [16892035] Bioinformatics. 2005 Nov 15;21(22):4084-91 [16159913] Bioinformatics. 2007 Mar 15;23(6):657-63 [17234643] Nat Rev Genet. 2007 May;8(5):341-52 [17440531] Nat Rev Cancer. 2009 Apr;9(4):274-84 [19308067] Cancer Res. 2009 May 1;69(9):4059-66 [19366792] Nature. 2010 Feb 18;463(7283):899-905 [20164920] BMC Surg. 2010;10:27 [20875094] Cancer Res. 2010 Dec 15;70(24):10202-12 [21159642] Nat Rev Cancer. 2011 Feb;11(2):135-41 [21258397] Cell. 2011 Mar 4;144(5):646-74 [21376230] Nat Rev Cancer. 2011 Oct;11(10):735-48 [21941285] Cell. 2011 Oct 14;147(2):275-92 [22000009] N Engl J Med. 2012 Mar 8;366(10):883-92 [22397650] Gastroenterology. 2012 Apr;142(4):957-966.e12 [22202459] Nat Med. 2013 Nov;19(11):1423-37 [24202395] Ann Surg. 2002 Mar;235(3):373-82 [11882759] Nat Rev Cancer. 2002 Aug;2(8):563-72 [12154349] Nat Genet. 2003 Jan;33(1):49-54 [12469122] J Cancer Res Clin Oncol. 2003 Jan;129(1):43-51 [12618900] Nat Med. 2003 Apr;9(4):416-23 [12640447] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15901-5 [14665696] Cancer Res. 1988 Apr 1;48(7):1943-8 [3349467] Surg Clin North Am. 1997 Feb;77(1):27-48 [9092116] J Clin Invest. 2005 Jan;115(1):44-55 [15630443] Cancer Cell. 2006 Aug;10(2):99-111 [16904609] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.7150/ijbs.10583 ER - TY - JOUR T1 - Association of polymorphisms in drug transporter genes (SLCO1B1 and SLC10A1) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort. AN - 1640851596; 25498879 AB - This study investigated the association between genetic variants in two hepatic uptake transporter genes (SLCO1B1 and SLC10A1) and the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in a Chinese cohort. The frequencies and distributions of single nucleotide polymorphisms (SNPs) and haplotypes of these genes were compared among 89 incident ATDH cases and 356 matched ATDH-free controls using a multivariate conditional logistic regression analysis. After correction for potential confounding factors, significant differences were found in polymorphism of rs4149014 under an addictive model (P = 0.008) and a recessive model (P = 0.016). The result of haplotype analysis suggested that patients carrying at least one SLCO1B1*15 haplotype had a higher risk of ATDH (odds ratio (OR) = 1.74, 95% confidence intervals (CI): 1.04-2.90, P = 0.034) in comparison with those carrying SLCO1B1*1a or SLCO1B1*1b haplotypes. These findings indicate that genetic variants of SLCO1B1 are associated with the development of ATDH in Chinese population. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Tuberculosis (Edinburgh, Scotland) AU - Chen, Ru AU - Wang, Jing AU - Tang, Shaowen AU - Zhang, Yuan AU - Lv, Xiaozhen AU - Wu, Shanshan AU - Xia, Yinyin AU - Deng, Peiyuan AU - Ma, Yu AU - Tu, Dehua AU - Chen, Dafang AU - Zhan, Siyan AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China. ; Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. ; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada. ; Clinical Research Division, Peking University Institute of Mental Health, and Key Laboratory for Mental Health, Ministry of Health, Beijing, China. ; Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. ; Center for Drug Reassessment, State Food and Drug Administration, Beijing, China. ; Department of Tuberculosis Treatment, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China. ; Department of Tuberculosis Treatment, Beijing Institute for Tuberculosis Control, Beijing, China. ; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China. Electronic address: siyan-zhan@bjmu.edu.cn. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 68 EP - 74 VL - 95 IS - 1 KW - Antitubercular Agents KW - 0 KW - Organic Anion Transporters KW - Organic Anion Transporters, Sodium-Dependent KW - SLCO1B1 protein, human KW - Solute Carrier Organic Anion Transporter Family Member 1b1 KW - Symporters KW - sodium-bile acid cotransporter KW - 145420-23-1 KW - Index Medicus KW - Anti-tuberculosis drug KW - Drug transporter KW - Hepatotoxicity KW - Genotyping Techniques KW - Haplotypes -- genetics KW - Humans KW - Adult KW - Linkage Disequilibrium -- genetics KW - China -- ethnology KW - Male KW - Female KW - Tuberculosis, Pulmonary -- genetics KW - Organic Anion Transporters -- genetics KW - Chemical and Drug Induced Liver Injury -- genetics KW - Symporters -- genetics KW - Tuberculosis, Pulmonary -- ethnology KW - Organic Anion Transporters, Sodium-Dependent -- genetics KW - Antitubercular Agents -- adverse effects KW - Polymorphism, Single Nucleotide -- genetics KW - Tuberculosis, Pulmonary -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640851596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tuberculosis+%28Edinburgh%2C+Scotland%29&rft.atitle=Association+of+polymorphisms+in+drug+transporter+genes+%28SLCO1B1+and+SLC10A1%29+and+anti-tuberculosis+drug-induced+hepatotoxicity+in+a+Chinese+cohort.&rft.au=Chen%2C+Ru%3BWang%2C+Jing%3BTang%2C+Shaowen%3BZhang%2C+Yuan%3BLv%2C+Xiaozhen%3BWu%2C+Shanshan%3BXia%2C+Yinyin%3BDeng%2C+Peiyuan%3BMa%2C+Yu%3BTu%2C+Dehua%3BChen%2C+Dafang%3BZhan%2C+Siyan&rft.aulast=Chen&rft.aufirst=Ru&rft.date=2015-01-01&rft.volume=95&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Tuberculosis+%28Edinburgh%2C+Scotland%29&rft.issn=1873-281X&rft_id=info:doi/10.1016%2Fj.tube.2014.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-18 N1 - Date created - 2014-12-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tube.2014.11.004 ER - TY - JOUR T1 - Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases. AN - 1640482809; 25536637 AB - Traditional Chinese Medicine (TCM) with its focus on herbal use became popular worldwide. Treatment was perceived as safe, with neglect of rare adverse reactions including liver injury. To compile worldwide cases of liver injury by herbal TCM, we undertook a selective literature search in the PubMed database and searched for the items Traditional Chinese Medicine, TCM, Traditional Asian Medicine, and Traditional Oriental Medicine, also combined with the terms herbal hepatotoxicity or herb induced liver injury. The search focused primarily on English-language case reports, case series, and clinical reviews. We identified reported hepatotoxicity cases in 77 relevant publications with 57 different herbs and herbal mixtures of TCM, which were further analyzed for causality by the Council for International Organizations of Medical Sciences (CIOMS) scale, positive reexposure test results, or both. Causality was established for 28/57 different herbs or herbal mixtures, Bai Xian Pi, Bo He, Ci Wu Jia, Chuan Lian Zi, Da Huang, Gan Cao, Ge Gen, Ho Shou Wu, Huang Qin, Hwang Geun Cho, Ji Gu Cao, Ji Xue Cao, Jin Bu Huan, Jue Ming Zi, Jiguja, Kudzu, Ling Yang Qing Fei Keli, Lu Cha, Rhen Shen, Ma Huang, Shou Wu Pian, Shan Chi, Shen Min, Syo Saiko To, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, and Zhen Chu Cao. In conclusion, this compilation of liver injury cases establishes causality for 28/57 different TCM herbs and herbal mixtures, aiding diagnosis for physicians who care for patients with liver disease possibly related to herbal TCM. JF - Annals of hepatology AU - Teschke, Rolf AU - Zhang, Li AU - Long, Hongzhu AU - Schwarzenboeck, Alexander AU - Schmidt-Taenzer, Wolfgang AU - Genthner, Alexander AU - Wolff, Albrecht AU - Frenzel, Christian AU - Schulze, Johannes AU - Eickhoff, Axel AD - Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt/ Main, Germany. ; Center for Drug Reevaluation, China Food and Drug Administration, Beijing, China. ; Department of Internal Medicine, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China. ; Department of Internal Medicine II, Division of Gastroenterology, Hepatology and Infectious Diseases, Friedrich Schiller University Jena, Germany. ; Department of Medicine I, University Medical Center Hamburg Eppendorf, Germany. ; Institute of Industrial, Environmental and Social Medicine, Medical Faculty of the Goethe University Frankfurt/Main, Germany. PY - 2015 SP - 7 EP - 19 VL - 14 IS - 1 SN - 1665-2681, 1665-2681 KW - Drugs, Chinese Herbal KW - 0 KW - Index Medicus KW - Humans KW - Drugs, Chinese Herbal -- adverse effects KW - Chemical and Drug Induced Liver Injury -- etiology KW - Medicine, Chinese Traditional KW - Phytotherapy -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1640482809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+hepatology&rft.atitle=Traditional+Chinese+Medicine+and+herbal+hepatotoxicity%3A+a+tabular+compilation+of+reported+cases.&rft.au=Teschke%2C+Rolf%3BZhang%2C+Li%3BLong%2C+Hongzhu%3BSchwarzenboeck%2C+Alexander%3BSchmidt-Taenzer%2C+Wolfgang%3BGenthner%2C+Alexander%3BWolff%2C+Albrecht%3BFrenzel%2C+Christian%3BSchulze%2C+Johannes%3BEickhoff%2C+Axel&rft.aulast=Teschke&rft.aufirst=Rolf&rft.date=2015-01-01&rft.volume=14&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Annals+of+hepatology&rft.issn=16652681&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-24 N1 - Date created - 2014-12-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Serum PCB concentrations in residents of Calcasieu and Lafayette Parishes, Louisiana with comparison to the U.S. population. AN - 1629585414; 25163413 AB - In 2002, a cross-sectional study designed to compare the serum dioxin toxic equivalent concentrations (TEQ) of a population-based sample of Calcasieu Parish, Louisiana residents, to Lafayette Parish was conducted. The mono-ortho polychlorinated biphenyls (PCBs) were measured in order to calculate the TEQ. We compared the sum of lipid adjusted serum concentrations of 27 PCB congeners (total PCBs) in residents of these two parishes and also by their demographic characteristics. The geometric means (GM) [standard errors (SE)] of the concentrations (ngg(-1) lipids) of total PCBs in participants from Calcasieu Parish and Lafayette Parish were 154 (11.8) and 168.6 (20.8) (T-test p=0.54), respectively. Various percentiles of the distribution of serum total PCB concentrations were similar in the two parishes. After adjusting by age and race in the ANCOVA regression model, the adjusted GM for the lipid adjusted total PCBs was statistically higher in the residents in Lafayette than in Calcasieu Parish regardless of age or race (P=0.007). The adjusted GM of lipid adjusted total PCBs for African Americans was significantly higher than for Whites (p<0.001). Serum total PCB levels in residents of both parishes increased linearly with age (P<0.001). The congener profiles were similar in residents of both parishes. We also compared the GMs of a sum of 8 PCBs in Calcasieu and Lafayette Parish residents to those from a representative sample of the U.S. general population in 2001-2002 and they were not significantly different between parishes or between the parish data and the U.S. general population. Published by Elsevier Ltd. JF - Chemosphere AU - Wong, Lee-Yang AU - Uddin, Mohammed S AU - Turner, Wayman AU - Ragin, Angela D AU - Dearwent, Steve AD - National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. Electronic address: lyw8@cdc.gov. ; Agency for Toxic Substances and Disease Registry, Atlanta, GA 30341, United States. ; National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. ; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States. Y1 - 2015/01// PY - 2015 DA - January 2015 SP - 156 EP - 162 VL - 118 KW - Dioxins KW - 0 KW - Environmental Pollutants KW - Lipids KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Population-based cross-sectional study KW - Polychlorinated biphenyls KW - Serum KW - Environmental health KW - United States KW - Lipids -- blood KW - Young Adult KW - Body Burden KW - Humans KW - Cross-Sectional Studies KW - Dioxins -- blood KW - Adult KW - Data Interpretation, Statistical KW - Middle Aged KW - Louisiana KW - Adolescent KW - Female KW - Male KW - Environmental Exposure -- statistics & numerical data KW - Polychlorinated Biphenyls -- blood KW - Environmental Exposure -- analysis KW - Environmental Pollutants -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629585414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=Serum+PCB+concentrations+in+residents+of+Calcasieu+and+Lafayette+Parishes%2C+Louisiana+with+comparison+to+the+U.S.+population.&rft.au=Wong%2C+Lee-Yang%3BUddin%2C+Mohammed+S%3BTurner%2C+Wayman%3BRagin%2C+Angela+D%3BDearwent%2C+Steve&rft.aulast=Wong&rft.aufirst=Lee-Yang&rft.date=2015-01-01&rft.volume=118&rft.issue=&rft.spage=156&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=1879-1298&rft_id=info:doi/10.1016%2Fj.chemosphere.2014.07.073 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-16 N1 - Date created - 2014-12-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.chemosphere.2014.07.073 ER - TY - JOUR T1 - Effect of silica and gold nanoparticles on macrophage proliferation, activation markers, cytokine production, and phagocytosis in vitro AN - 1647009885; 21327250 AB - The accumulation of durable nanoparticles (NPs) in macrophages following systemic administration is well described. The ultimate biological impact of this accumulation on macrophage function, however, is not fully understood. In this study, nontoxic doses of two durable NPs, SiO2 and Au, at particle sizes of ~10 nm and 300 nm were used to evaluate the effect of bioaccumulation on macrophage function in vitro using RAW 264.7 mouse macrophage-like cells as a model system. Cell proliferation, cell cycle, cytokine production, surface marker activation, and phagocytosis responses were evaluated through a panel of assays using flow cytometry and confocal microscopy. The most dramatic change in RAW 264.7 cell function was a reduction in phagocytosis as monitored by the uptake of Escherichia coli. Cells exposed to both 10 nm Au NPs and 10 nm SiO2 NPs showed ~50% decrease in phagocytosis, while the larger NPs caused a less dramatic reduction. In addition to modifying phagocytosis profiles, 10 nm SiO2 NPs caused changes in proliferation, cell cycle, and cell morphology. Au NPs had no effect on cell cycle, cytokine production, or surface markers and caused interference in phagocytosis in the form of quenching when the assay was performed via flow cytometry. Confocal microscopy analysis was used to minimize this interference and demonstrated that both sizes of Au NPs decreased the phagocytosis of E. coli. Overall, our results demonstrate that Au and SiO2 NP uptake by macrophages can influence macrophage phagocytosis in vitro without altering surface markers and cytokine production in vitro. While the biological impact of these findings remains unclear, our results indicate that bioaccumulation of durable NPs within the macrophages may lead to a suppression of bacterial uptake and possibly impair bactericidal activity. JF - International Journal of Nanomedicine AU - Bancos, Simona AU - Stevens, David L AU - Tyner, Katherine M AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2014/12/24/ PY - 2014 DA - 2014 Dec 24 SP - 183 EP - 206 PB - Dove Medical Press Ltd, Beechfield House Macclesfield SK11 0JL United Kingdom VL - 10 SN - 1176-9114, 1176-9114 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - bioaccumulation KW - phagocytosis KW - gold nanoparticles KW - silica nanoparticles KW - macrophage function KW - Particle size KW - Macrophages KW - Cell cycle KW - Cell activation KW - Flow cytometry KW - Silica KW - Bioaccumulation KW - Confocal microscopy KW - Escherichia coli KW - Cytology KW - Cytokines KW - Gold KW - Phagocytosis KW - Cell proliferation KW - nanoparticles KW - Bactericidal activity KW - Surface markers KW - nanotechnology KW - W 30950:Waste Treatment & Pollution Clean-up KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647009885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Nanomedicine&rft.atitle=Effect+of+silica+and+gold+nanoparticles+on+macrophage+proliferation%2C+activation+markers%2C+cytokine+production%2C+and+phagocytosis+in+vitro&rft.au=Bancos%2C+Simona%3BStevens%2C+David+L%3BTyner%2C+Katherine+M&rft.aulast=Bancos&rft.aufirst=Simona&rft.date=2014-12-24&rft.volume=10&rft.issue=&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Nanomedicine&rft.issn=11769114&rft_id=info:doi/10.2147%2FIJN.S72580 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Macrophages; Particle size; Cell cycle; Cell activation; Flow cytometry; Bioaccumulation; Silica; Confocal microscopy; Gold; Cytokines; Cytology; Cell proliferation; Phagocytosis; Bactericidal activity; nanoparticles; Surface markers; nanotechnology; Escherichia coli DO - http://dx.doi.org/10.2147/IJN.S72580 ER - TY - JOUR T1 - Evaluating Ebola therapies--the case for RCTs. AN - 1639498758; 25470568 JF - The New England journal of medicine AU - Cox, Edward AU - Borio, Luciana AU - Temple, Robert AD - From the Center for Drug Evaluation and Research (E.C., R.T.) and the Office of the Commissioner (L.B.), Food and Drug Administration, Silver Spring, MD. Y1 - 2014/12/18/ PY - 2014 DA - 2014 Dec 18 SP - 2350 EP - 2351 VL - 371 IS - 25 KW - Abridged Index Medicus KW - Index Medicus KW - Epidemics KW - Humans KW - Ebolavirus KW - Randomized Controlled Trials as Topic KW - Hemorrhagic Fever, Ebola -- mortality KW - Hemorrhagic Fever, Ebola -- therapy KW - Hemorrhagic Fever, Ebola -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639498758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Evaluating+Ebola+therapies--the+case+for+RCTs.&rft.au=Cox%2C+Edward%3BBorio%2C+Luciana%3BTemple%2C+Robert&rft.aulast=Cox&rft.aufirst=Edward&rft.date=2014-12-18&rft.volume=371&rft.issue=25&rft.spage=2350&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMp1414145 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-05 N1 - Date created - 2014-12-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMp1414145 ER - TY - JOUR T1 - Human biological monitoring for exposure assessment in response to an incident involving hazardous materials. AN - 1637568937; 24631920 AB - Biological monitoring in humans (HBM) is widely used in the field of occupational and environmental health. In the situation of an unexpected release of hazardous materials HBM may contribute to the medical support and treatment of exposed individuals from the general population or of emergency responders. Such exposure information may also be used to respond to individual concerns such as questions about a possible relationship between the chemicals released during the incident and health effects. In The Netherlands a guideline was prepared to support early decision-making about the possible use of HBM for exposure assessment during or as soon as possible following a chemical incident. The application of HBM in such an emergency setting is not much different from situations where HBM is normally used but there are some issues that need extra attention such as the choice of the biomarker, the biological media to be sampled, the time point at which biological samples should be collected, the ethics approval and technical implementation of the study protocol and the interpretation and communication of the study results. These issues addressed in the new guideline will support the use of HBM in the management of chemical disasters. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Scheepers, Paul T J AU - van Brederode, Nelly E AU - Bos, Peter M J AU - Nijhuis, Nicole J AU - van de Weerdt, Rik H J AU - van der Woude, Irene AU - Eggens, Martin L AD - Department for Health Evidence, Radboud university medical center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: paul.scheepers@radboudumc.nl. ; National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: nelly.van.brederode@rivm.nl. ; National Institute of Public Health and the Environment, PO Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address: peter.bos@rivm.nl. ; Department of Environmental Health, Public Health Service Amsterdam, PO Box 2200, 1000 CE Amsterdam, The Netherlands. Electronic address: nnijhuis@ggd.amsterdam.nl. ; Public Health Services Gelderland-Midden, Postbus 5364, 6802 EJ Arnhem, The Netherlands. Electronic address: rik.van.de.weerdt@vggm.nl. ; Medical Emergency Preparedness and Planning Office, PO Box 9154, 3007 AD Rotterdam, The Netherlands. Electronic address: i.vanderwoude@veiligheidsregio-rr.nl. ; Public Health Service Groningen, Municipal Health Department, PO Box 584, 9700 AN Groningen, The Netherlands. Electronic address: martin.eggens@ggd.groningen.nl. Y1 - 2014/12/15/ PY - 2014 DA - 2014 Dec 15 SP - 295 EP - 305 VL - 231 IS - 3 KW - Biomarkers KW - 0 KW - Hazardous Substances KW - Index Medicus KW - Health surveillance KW - Hazardous materials KW - Emergency response KW - Disaster management KW - Acute toxicity KW - Exposure assessment KW - Humans KW - Guidelines as Topic KW - Netherlands KW - Biomarkers -- analysis KW - Environmental Exposure -- analysis KW - Chemical Hazard Release KW - Environmental Exposure -- adverse effects KW - Decision Making KW - Hazardous Substances -- analysis KW - Environmental Monitoring -- methods KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1637568937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Human+biological+monitoring+for+exposure+assessment+in+response+to+an+incident+involving+hazardous+materials.&rft.au=Scheepers%2C+Paul+T+J%3Bvan+Brederode%2C+Nelly+E%3BBos%2C+Peter+M+J%3BNijhuis%2C+Nicole+J%3Bvan+de+Weerdt%2C+Rik+H+J%3Bvan+der+Woude%2C+Irene%3BEggens%2C+Martin+L&rft.aulast=Scheepers&rft.aufirst=Paul+T&rft.date=2014-12-15&rft.volume=231&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2014.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-11 N1 - Date created - 2014-12-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2014.03.002 ER - TY - JOUR T1 - Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. AN - 1627071861; 25027329 AB - Genome-wide association studies (GWAS) have mapped risk alleles for at least 10 distinct cancers to a small region of 63 000 bp on chromosome 5p15.33. This region harbors the TERT and CLPTM1L genes; the former encodes the catalytic subunit of telomerase reverse transcriptase and the latter may play a role in apoptosis. To investigate further the genetic architecture of common susceptibility alleles in this region, we conducted an agnostic subset-based meta-analysis (association analysis based on subsets) across six distinct cancers in 34 248 cases and 45 036 controls. Based on sequential conditional analysis, we identified as many as six independent risk loci marked by common single-nucleotide polymorphisms: five in the TERT gene (Region 1: rs7726159, P = 2.10 × 10(-39); Region 3: rs2853677, P = 3.30 × 10(-36) and PConditional = 2.36 × 10(-8); Region 4: rs2736098, P = 3.87 × 10(-12) and PConditional = 5.19 × 10(-6), Region 5: rs13172201, P = 0.041 and PConditional = 2.04 × 10(-6); and Region 6: rs10069690, P = 7.49 × 10(-15) and PConditional = 5.35 × 10(-7)) and one in the neighboring CLPTM1L gene (Region 2: rs451360; P = 1.90 × 10(-18) and PConditional = 7.06 × 10(-16)). Between three and five cancers mapped to each independent locus with both risk-enhancing and protective effects. Allele-specific effects on DNA methylation were seen for a subset of risk loci, indicating that methylation and subsequent effects on gene expression may contribute to the biology of risk variants on 5p15.33. Our results provide strong support for extensive pleiotropy across this region of 5p15.33, to an extent not previously observed in other cancer susceptibility loci. 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AU - Brinton, Louise A AU - Brotzman, Michelle AU - Bueno-de-Mesquita, H Bas AU - Buring, Julie E AU - Butler, Mary Ann AU - Cai, Qiuyin AU - Cancel-Tassin, Geraldine AU - Canzian, Federico AU - Cao, Guangwen AU - Caporaso, Neil E AU - Carrato, Alfredo AU - Carreon, Tania AU - Carta, Angela AU - Chang, Gee-Chen AU - Chang, I-Shou AU - Chang-Claude, Jenny AU - Che, Xu AU - Chen, Chien-Jen AU - Chen, Chih-Yi AU - Chen, Chung-Hsing AU - Chen, Constance AU - Chen, Kuan-Yu AU - Chen, Yuh-Min AU - Chokkalingam, Anand P AU - Chu, Lisa W AU - Clavel-Chapelon, Francoise AU - Colditz, Graham A AU - Colt, Joanne S AU - Conti, David AU - Cook, Michael B AU - Cortessis, Victoria K AU - Crawford, E David AU - Cussenot, Olivier AU - Davis, Faith G AU - De Vivo, Immaculata AU - Deng, Xiang AU - Ding, Ti AU - Dinney, Colin P AU - Di Stefano, Anna Luisa AU - Diver, W Ryan AU - Duell, Eric J AU - Elena, Joanne W AU - Fan, Jin-Hu AU - Feigelson, Heather Spencer AU - Feychting, Maria AU - Figueroa, Jonine D AU - Flanagan, Adrienne M AU - Fraumeni, Joseph F AU - Freedman, Neal D AU - Fridley, Brooke L AU - Fuchs, Charles S AU - Gago-Dominguez, Manuela AU - Gallinger, Steven AU - Gao, Yu-Tang AU - Gapstur, Susan M AU - Garcia-Closas, Montserrat AU - Garcia-Closas, Reina AU - Gastier-Foster, Julie M AU - Gaziano, J Michael AU - Gerhard, Daniela S AU - Giffen, Carol A AU - Giles, Graham G AU - Gillanders, Elizabeth M AU - Giovannucci, Edward L AU - Goggins, Michael AU - Gokgoz, Nalan AU - Goldstein, Alisa M AU - Gonzalez, Carlos AU - Gorlick, Richard AU - Greene, Mark H AU - Gross, Myron AU - Grossman, H Barton AU - Grubb, Robert AU - Gu, Jian AU - Guan, Peng AU - Haiman, Christopher A AU - Hallmans, Goran AU - Hankinson, Susan E AU - Harris, Curtis C AU - Hartge, Patricia AU - Hattinger, Claudia AU - Hayes, Richard B AU - He, Qincheng AU - Helman, Lee AU - Henderson, Brian E AU - Henriksson, Roger AU - Hoffman-Bolton, Judith AU - Hohensee, Chancellor AU - Holly, Elizabeth A AU - Hong, Yun-Chul AU - Hoover, Robert N AU - Hosgood, H Dean AU - Hsiao, Chin-Fu AU - Hsing, Ann W AU - Hsiung, Chao Agnes AU - Hu, Nan AU - Hu, Wei AU - Hu, Zhibin AU - Huang, Ming-Shyan AU - Hunter, David J AU - Inskip, Peter D AU - Ito, Hidemi AU - Jacobs, Eric J AU - Jacobs, Kevin B AU - Jenab, Mazda AU - Ji, Bu-Tian AU - Johansen, Christoffer AU - Johansson, Mattias AU - Johnson, Alison AU - Kaaks, Rudolf AU - Kamat, Ashish M AU - Kamineni, Aruna AU - Karagas, Margaret AU - Khanna, Chand AU - Khaw, Kay-Tee AU - Kim, Christopher AU - Kim, In-Sam AU - Kim, Jin Hee AU - Kim, Yeul Hong AU - Kim, Young-Chul AU - Kim, Young Tae AU - Kang, Chang Hyun AU - Jung, Yoo Jin AU - Kitahara, Cari M AU - Klein, Alison P AU - Klein, Robert AU - Kogevinas, Manolis AU - Koh, Woon-Puay AU - Kohno, Takashi AU - Kolonel, Laurence N AU - Kooperberg, Charles AU - Kratz, Christian P AU - Krogh, Vittorio AU - Kunitoh, Hideo AU - Kurtz, Robert C AU - Kurucu, Nilgun AU - Lan, Qing AU - Lathrop, Mark AU - Lau, Ching C AU - Lecanda, Fernando AU - Lee, Kyoung-Mu AU - Lee, Maxwell P AU - Le Marchand, Loic AU - Lerner, Seth P AU - Li, Donghui AU - Liao, Linda M AU - Lim, Wei-Yen AU - Lin, Dongxin AU - Lin, Jie AU - Lindstrom, Sara AU - Linet, Martha S AU - Lissowska, Jolanta AU - Liu, Jianjun AU - Ljungberg, Börje AU - Lloreta, Josep AU - Lu, Daru AU - Ma, Jing AU - Malats, Nuria AU - Mannisto, Satu AU - Marina, Neyssa AU - Mastrangelo, Giuseppe AU - Matsuo, Keitaro AU - McGlynn, Katherine A AU - McKean-Cowdin, Roberta AU - McNeill, Lorna H AU - McWilliams, Robert R AU - Melin, Beatrice S AU - Meltzer, Paul S AU - Mensah, James E AU - Miao, Xiaoping AU - Michaud, Dominique S AU - Mondul, Alison M AU - Moore, Lee E AU - Muir, Kenneth AU - Niwa, Shelley AU - Olson, Sara H AU - Orr, Nick AU - Panico, Salvatore AU - Park, Jae Yong AU - Patel, Alpa V AU - Patino-Garcia, Ana AU - Pavanello, Sofia AU - Peeters, Petra H M AU - Peplonska, Beata AU - Peters, Ulrike AU - Petersen, Gloria M AU - Picci, Piero AU - Pike, Malcolm C AU - Porru, Stefano AU - Prescott, Jennifer AU - Pu, Xia AU - Purdue, Mark P AU - Qiao, You-Lin AU - Rajaraman, Preetha AU - Riboli, Elio AU - Risch, Harvey A AU - Rodabough, Rebecca J AU - Rothman, Nathaniel AU - Ruder, Avima M AU - Ryu, Jeong-Seon AU - Sanson, Marc AU - Schned, Alan AU - Schumacher, Fredrick R AU - Schwartz, Ann G AU - Schwartz, Kendra L AU - Schwenn, Molly AU - Scotlandi, Katia AU - Seow, Adeline AU - Serra, Consol AU - Serra, Massimo AU - Sesso, Howard D AU - Severi, Gianluca AU - Shen, Hongbing AU - Shen, Min AU - Shete, Sanjay AU - Shiraishi, Kouya AU - Shu, Xiao-Ou AU - Siddiq, Afshan AU - Sierrasesumaga, Luis AU - Sierri, Sabina AU - Loon Sihoe, Alan Dart AU - Silverman, Debra T AU - Simon, Matthias AU - Southey, Melissa C AU - Spector, Logan AU - Spitz, Margaret AU - Stampfer, Meir AU - Stattin, Par AU - Stern, Mariana C AU - Stevens, Victoria L AU - Stolzenberg-Solomon, Rachael Z AU - Stram, Daniel O AU - Strom, Sara S AU - Su, Wu-Chou AU - Sund, Malin AU - Sung, Sook Whan AU - Swerdlow, Anthony AU - Tan, Wen AU - Tanaka, Hideo AU - Tang, Wei AU - Tang, Ze-Zhang AU - Tardon, Adonina AU - Tay, Evelyn AU - Taylor, Philip R AU - Tettey, Yao AU - Thomas, David M AU - Tirabosco, Roberto AU - Tjonneland, Anne AU - Tobias, Geoffrey S AU - Toro, Jorge R AU - Travis, Ruth C AU - Trichopoulos, Dimitrios AU - Troisi, Rebecca AU - Truelove, Ann AU - Tsai, Ying-Huang AU - Tucker, Margaret A AU - Tumino, Rosario AU - Van Den Berg, David AU - Van Den Eeden, Stephen K AU - Vermeulen, Roel AU - Vineis, Paolo AU - Visvanathan, Kala AU - Vogel, Ulla AU - Wang, Chaoyu AU - Wang, Chengfeng AU - Wang, Junwen AU - Wang, Sophia S AU - Weiderpass, Elisabete AU - Weinstein, Stephanie J AU - Wentzensen, Nicolas AU - Wheeler, William AU - White, Emily AU - Wiencke, John K AU - Wolk, Alicja AU - Wolpin, Brian M AU - Wong, Maria Pik AU - Wrensch, Margaret AU - Wu, Chen AU - Wu, Tangchun AU - Wu, Xifeng AU - Wu, Yi-Long AU - Wunder, Jay S AU - Xiang, Yong-Bing AU - Xu, Jun AU - Yang, Hannah P AU - Yang, Pan-Chyr AU - Yatabe, Yasushi AU - Ye, Yuanqing AU - Yeboah, Edward D AU - Yin, Zhihua AU - Ying, Chen AU - Yu, Chong-Jen AU - Yu, Kai AU - Yuan, Jian-Min AU - Zanetti, Krista A AU - Zeleniuch-Jacquotte, Anne AU - Zheng, Wei AU - Zhou, Baosen AU - Mirabello, Lisa AU - Savage, Sharon A AU - Kraft, Peter AU - Chanock, Stephen J AU - Yeager, Meredith AU - Landi, Maria Terese AU - Shi, Jianxin AU - Chatterjee, Nilanjan AU - Amundadottir, Laufey T AD - Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA. ; Division of Cancer Epidemiology and Genetics. ; Korle Bu Teaching Hospital, PO BOX 77, Accra, Ghana, University of Ghana Medical School, PO Box 4236, Accra, Ghana. ; Unit of Epidemiology, Institute of Environmental Medicine. ; Clinical Trial Service Unit and Epidemiological Studies Unit, University of Oxford, Oxford, UK. ; Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA. ; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA. ; Public Health Division of Gipuzkoa, Basque Regional Health Department, San Sebastian, Spain, CIBERESP, CIBER Epidemiologia y Salud Publica, Madrid, Spain. ; Geisel School of Medicine at Dartmouth, Hanover, NH, USA. ; Department of Radiation Sciences, Oncology. ; Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO, USA. ; Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Mt Sinai Hospital, University of Toronto, Toronto, ON, Canada. ; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Italy. ; Department of Obstetrics and Gynecology and Department of Population Health, New York University School of Medicine, New York, NY, USA, New York University Cancer Institute, New York, NY, USA. ; Department of Epidemiology, University of Washington, Seattle, WA, USA. ; Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine and. ; Division of Cancer Epidemiology and Genetics, Division of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA. ; Division of Cancer Prevention. ; Department of Clinical Sciences and Community Health, University of Milan, Department of Preventive Medicine, Fondazione IRCCS Ca' Granda Policlinico Hospital, Milan, Italy. ; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA, International Epidemiology Institute, Rockville, MD, USA. ; Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany. ; Institute for Translational Epidemiology, Hematology and Medical Oncology, Mount Sinai Hospital School of Medicine, New York, NY, USA. ; Division of Cancer Epidemiology and Genetics, Department of Oncology, University of Cambridge, Cambridge CB2 2RE, UK. ; Institut National de la Sante et de la Recherche Medicale (INSERM) and Institut Gustave Roussy, Villejuif, France. ; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA. ; International Agency for Research on Cancer (IARC-WHO), Lyon, France. ; Westat, Rockville, MD, USA. ; National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, The Netherlands. ; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. ; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, USA. ; CeRePP, Paris, France, UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France. ; Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany. ; Department of Epidemiology, Second Military Medical University, Shanghai, China. ; Medical Oncology Department, Hospital Ramón y Cajal, Madrid, Spain. ; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. ; National Institute of Cancer Research. ; Department of Abdominal Surgery and. ; Genomics Research Center, Academia Sinica, Taipei, Taiwan, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan. ; Cancer Center, China Medical University Hospital, Taipei, Taiwan. ; Program in Molecular and Genetic Epidemiology. ; Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. ; Department of Epidemiology and Public Health, Yong Loo Lin School of Medicine and Chest Department, Taipei Veterans General Hospital, Taipei, Taiwan, College of Medical Science and Technology, Taipei Medical University, Taiwan. ; School of Public Health, University of California, Berkeley, CA, USA. ; Cancer Prevention Institute of California, Fremont, CA, USA. ; Inserm, Centre for Research in Epidemiology and Population Health (CESP), Villejuif, France. ; Washington University School of Medicine, St Louis, MO, USA. ; Urologic Oncology, University of Colorado, Aurora, CO, USA. ; CeRePP, Paris, France, AP-HP, Department of Urology, Tenon Hospital, GHU-Est, Paris, France, UPMC Univ Paris 06, GRC n°5, ONCOTYPE-URO, Paris, France. ; Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, AB, Canada T6G 2R3. ; Program in Molecular and Genetic Epidemiology, Department of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ; Shanxi Cancer Hospital, Taiyuan, Shanxi, People's Republic of China. ; Department of Urology. ; Service de Neurologie Mazarin, GH Pitie-Salpetriere, APHP, and UMR 975 INSERM-UPMC, CRICM, Paris, France. ; Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA. ; Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. ; Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, Bethesda, MD, USA. ; Shanghai Cancer Institute, Shanghai, People's Republic of China. ; Institute for Health Research, Kaiser Permanente, Denver, CO, USA. ; UCL Cancer Institute, Huntley Street, London WC1E 6BT, UK, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK. ; Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA. ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA, Channing Laboratory, Department of Medicine. ; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain. ; Samuel Lunenfeld Research Institute and. ; Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotaong University School of Medicine, Shanghai, China. ; Division of Cancer Epidemiology and Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK. ; Unidad de Investigación, Hospital Universitario de Canarias, La Laguna, Spain. ; Nationwide Children's Hospital, and The Ohio State University Department of Pathology and Pediatrics, Columbus, OH, USA. ; Division of Preventive Medicine, Department of Medicine and Division of Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Massachusetts Veteran's Epidemiology, Research and Information Center, Geriatric Research Education and Clinical Center, Veterans Affairs Boston Healthcare System, Boston, MA, USA. ; Office of Cancer Genomics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. ; Information Management Services Inc., Calverton, MD, USA. ; Cancer Epidemiology Centre, The Cancer Council Victoria & Centre for Molecular, Environmental, Genetic, and Analytic Epidemiology, The University of Melbourne, Victoria, Australia. ; Division of Cancer Control and Population Sciences and. ; Program in Molecular and Genetic Epidemiology, Department of Nutrition and. ; Department of Oncology, Department of Pathology and Department of Medicine, The Sol Goldman Pancreatic Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. ; Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain. ; Albert Einstein College of Medicine, The Children's Hospital at Montefiore, Bronx, NY, USA. ; Department of Laboratory Medicine and Pathology, School of Medicine, University of Minnesota, Minneapolis, MN, USA. ; Department of Urology, Washington University School of Medicine, St Louis, MO, USA. ; Department of Epidemiology. ; Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China. ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. ; Department of Public Health and Clinical Medicine/Nutritional Research. ; Channing Laboratory, Department of Medicine. ; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. ; Laboratory of Experimental Oncology, Orthopaedic Rizzoli Institute, Bologna, Italy. ; Division of Cancer Epidemiology and Genetics, Department of Population Health, New York University Langone Medical Center and Department of Environmental Medicine, New York University Langone Medical Center, New York University Cancer Institute, New York, NY, USA. ; Center for Cancer Research and. ; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. ; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea, Department of Preventive Medicine and. ; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. ; Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences and Taiwan Lung Cancer Tissue/Specimen Information Resource Center, National Health Research Institutes, Zhunan, Taiwan. ; Cancer Prevention Institute of California, Fremont, CA, USA, Stanford Cancer Institute, Stanford University, Stanford, CA, USA. ; Division of Biostatistics and Bioinformatics, Institute of Population Health Sciences and. ; Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing, China. ; Program in Molecular and Genetic Epidemiology, Department of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Broad Institute of Harvard and MIT, Cambridge, MA, USA. ; Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan. ; Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA, Bioinformed, LLC, Gaithersburg, MD, USA. ; Department of Oncology, Finsen Center, Rigshospitalet, Copenhagen, Denmark, Unit of Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark. ; International Agency for Research on Cancer (IARC-WHO), Lyon, France, Department of Public Health and Clinical Medicine. ; Vermont Cancer Registry, Burlington, VT, USA. ; Group Health Research Institute, Seattle, WA, USA. ; School of Clinical Medicine, University of Cambridge, UK. ; Department of Biochemistry and Department of Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. ; Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea. ; Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Republic of Korea, Department of Internal Medicine and Division of Brain and Division of Oncology/Hematology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea. ; Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, Hwasun-eup, Republic of Korea. ; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. ; Department of Oncology, Department of Pathology and Department of Medicine, The Sol Goldman Pancreatic Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ; Department of Medicine and. ; Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, National School of Public Health, Athens, Greece. ; Duke-NUS Graduate Medical School, Singapore, Singapore, Saw Swee Hock School of Public Health, National University of Singapore, Singapore. ; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan. ; Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA. ; Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. ; Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan, Department of Respiratory Medicine, Mitsui Memorial Hospital, Tokyo, Japan. ; Department of Pediatric Oncology, A.Y. Ankara Oncology Training and Research Hospital, Yenimahalle- Ankara, Turkey. ; Centre National de Genotypage, IG/CEA, Evry Cedex, France, Centre d'Étude du Polymorphism Humain (CEPH), Paris, France. ; Texas Children's Cancer and Hematology Centers. ; Department of Pediatrics, University Clinic of Navarra, Universidad de Navarra, Pamplona, Spain. ; Department of Preventive Medicine and Department of Environmental Health, Korea National Open University, Seoul, Republic of Korea. ; Scott Department of Urology and. ; Department of Gastrointestinal Medical Oncology. ; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. ; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. ; Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland. ; Human Genetics Division, Genome Institute of Singapore, Singapore, School of Life Sciences, Anhui Medical University, Hefei, China. ; Department of Surgical and Perioperative Sciences, Urology and Andrology and. ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. ; Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China, State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China. ; Department of Medicine, Channing Division of Network Medicine and Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. ; Centro Nacional de Investigaciones Oncologicas, Melchor Fernández Almagro, 3, Madrid E-28029, Spain. ; National Institute for Health and Welfare, Helsinki, Finland. ; Lucile Packard Children's Hospital, Stanford University, Palo Alto, CA, USA. ; Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy. ; Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan, Department of Preventive Medicine, Kyushu University Faculty of Medical Scicence, Fukuoka, Japan. ; Department of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, and Center for Community-Engaged Translational Research, Duncan Family Institute and. ; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. ; Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. ; Department of Epidemiology, Division of Biology and Medicine, Brown University, Providence, RI, USA. ; Health Sciences Research Institute, University of Warwick, Coventry, UK. ; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ; Complex Traits Genetics Team and. ; Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. ; Department of Biochemistry and Department of Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea, Lung Cancer Center, Kyungpook National University Medical Center, Daegu, Republic of Korea. ; Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Utrecht, The Netherlands, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. ; Nofer Institute of Occupational Medicine, Lodz, Poland. ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ; Department of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Beijing, People's Republic of China. ; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. ; Yale School of Public Health, New Haven, CT, USA. ; Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea. ; Karmanos Cancer Institute and Department of Oncology and. ; Karmanos Cancer Institute and Department of Family Medicine and Public Health Sciences, Wayne State University School of Medicine, Detroit, MI, USA. ; Maine Cancer Registry, Augusta, ME, USA. ; Centre for Research in Occupational Health, Universitat Pompeu Fabra, Barcelona, Spain, CIBER of Epidemiology and Public Health (CIBERESP). ; Department of Biostatistics, MD Anderson Cancer Center, Houston, TX, USA. ; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK. ; Nutritional Epidemiology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. ; Department of Surgery, Division of Cardiothoracic Surgery, Queen Mary Hospital, Hong Kong, China. ; Department of Neurosurgery, University of Bonn Medical Center, Bonn, Germany. ; Department of Pathology, The University of Melbourne, Melbourne, VIC, Australia. ; University of Minnesota, Minneapolis, MN, USA. ; Dan L. Duncan Center, Baylor College of Medicine, Houston, TX, USA. ; Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. ; Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan. ; Department of Surgical and Perioperative Sciences/Surgery, Umeå University, Umeå, Sweden. ; Department of Thoracic and Cardiovascular Surgery, Seoul St Mary's Hospital, Seoul, South Korea. ; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK, Division of Breast Cancer Research, Institute of Cancer Research, London, UK. ; Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain. ; Sir Peter MacCallum Department of Oncology, University of Melbourne, St Andrew's Place, East Melbourne, VIC, Australia. ; Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK. ; Danish Cancer Society Research Center, Copenhagen, Denmark. ; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. ; Department of Pulmonary Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan. ; Cancer Registry Associazione Iblea Ricerca Epidemiologica, Onlus and Asp Ragusa, Ragusa Italy. ; Kaiser Permanente Northern California, Oakland, CA, USA. ; Division of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands. ; Imperial College, London, UK, Human Genetics Foundation (HuGeF), Torino Italy. ; National Research Centre for the Working Environment, Copenhagen, Denmark, National Food Institute, Technical University of Denmark, Soborg, Denmark. ; Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Division of Cancer Epidemiology and Genetics, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA, Department of Biochemistry and Centre for Genomic Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. ; Division of Cancer Etiology, Department of Population Sciences, City of Hope and the Beckman Research Institute, Duarte, CA, USA. ; Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway, Department of Research, Cancer Registry of Norway, Oslo, Norway, Department of Medical Epidemiology and Biostatistics and Samfundet Folkhälsan, Helsinki, Finland. ; University of California San Francisco, San Francisco, CA, USA. ; Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. ; Department of Pathology and. ; Guangdong Lung Cancer Institute, Medical Research Center and Cancer Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. ; School of Public Health, Li Ka Shing (LKS) Faculty of Medicine, The University of Hong Kong, Hong Kong, China. ; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital and. ; University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA and. ; Department of Population Health, New York University School of Medicine, New York, NY, USA, New York University Cancer Institute, New York, NY, USA. ; Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. ; Division of Cancer Epidemiology and Genetics, amundadottirl@mail.nih.gov. Y1 - 2014/12/15/ PY - 2014 DA - 2014 Dec 15 SP - 6616 EP - 6633 VL - 23 IS - 24 KW - CLPTM1L protein, human KW - 0 KW - Membrane Proteins KW - Neoplasm Proteins KW - TERT protein, human KW - EC 2.7.7.49 KW - Telomerase KW - Index Medicus KW - Risk KW - Polymorphism, Single Nucleotide KW - Odds Ratio KW - Alleles KW - Gene Frequency KW - DNA Methylation KW - Humans KW - Genetic Predisposition to Disease KW - Computational Biology KW - Epigenesis, Genetic KW - Male KW - Female KW - Genome-Wide Association Study KW - Gene Expression Regulation, Neoplastic KW - Neoplasms -- pathology KW - Genetic Loci KW - Neoplasm Proteins -- genetics KW - Chromosomes, Human, Pair 5 -- chemistry KW - Telomerase -- genetics KW - Membrane Proteins -- genetics KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627071861?accountid=14244 L2 - 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15;74(10):2785-95 [24648346] Nat Genet. 2011 Nov;43(11):1108-13 [21983787] Nat Genet. 2011 Dec;43(12):1210-4 [22037553] Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 [22064851] Nat Genet. 2012 Jan;44(1):62-6 [22158540] Nat Genet. 2012 Jan;44(1):6-7 [22200770] Cancer Lett. 2012 Jun 28;319(2):130-5 [22269209] Genet Epidemiol. 2012 May;36(4):368-72 [22539396] Am J Hum Genet. 2012 May 4;90(5):821-35 [22560090] N1 - Last updated - 2017-02-10 DO - http://dx.doi.org/10.1093/hmg/ddu363 ER - TY - JOUR T1 - Thymol treatment of bacteria prior to matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis aids in identifying certain bacteria at the subspecies level. AN - 1620587832; 25366408 AB - The identification of bacteria based on mass spectra produced by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has become routine since its introduction in 1996. The major drawback is that bacterial patterns produced by MALDI are dependent on sample preparation prior to analysis. This results in poor reproducibility in identifying bacterial types and between laboratories. The need for a more broadly applicable and useful sample handling procedure is warranted. Thymol was added to the suspension solvent of bacteria prior to MALDI analysis. The suspension solvent consisted of ethanol, water and TFA. The bacterium was added to the thymol suspension solvent and heated. An aliquot of the bacterial suspension was mixed directly with the matrix solution at a 9:1 ratio, matrix/bacteria solution, respectively. The mixture was then placed on the MALDI plate and allowed to air dry before MALDI analysis. The thymol method improved the quality of spectra and number of peaks when compared to other sample preparation procedures studied. The bacterium-identifying biomarkers assigned to four strains of E. coli were statistically 95% reproducible analyzed on three separate days. The thymol method successfully differentiated between the four E. coli strains. In addition, the thymol procedure could identify nine out of ten S. enterica serovars over a 3-day period and nine S. Typhimurium strains from the other ten serovars 90% of the time over the same period. The thymol method can identify certain bacteria at the sub-species level and yield reproducible results over time. It improves the quality of spectra by increasing the number of peaks when compared to the other sample preparation methods assessed in this study. Published in 2014. This article is a U.S. Government work and is in the public domain in the USA. Published in 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Rapid communications in mass spectrometry : RCM AU - Holland, Ricky D AU - Wilkes, Jon G AU - Cooper, Willie M AU - Alusta, Pierre AU - Williams, Anna AU - Pearce, Bruce AU - Beaudoin, Michael AU - Buzatu, Dan AD - Division of Systems Biology/Innovative Safety and Technologies Branch, USFDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Y1 - 2014/12/15/ PY - 2014 DA - 2014 Dec 15 SP - 2617 EP - 2626 VL - 28 IS - 23 KW - Biomarkers KW - 0 KW - Thymol KW - 3J50XA376E KW - Index Medicus KW - Biomarkers -- chemistry KW - Reproducibility of Results KW - Biomarkers -- analysis KW - Thymol -- chemistry KW - Bacterial Typing Techniques -- methods KW - Bacteria -- classification KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods KW - Bacteria -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1620587832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.atitle=Thymol+treatment+of+bacteria+prior+to+matrix-assisted+laser+desorption%2Fionization+time-of-flight+mass+spectrometric+analysis+aids+in+identifying+certain+bacteria+at+the+subspecies+level.&rft.au=Holland%2C+Ricky+D%3BWilkes%2C+Jon+G%3BCooper%2C+Willie+M%3BAlusta%2C+Pierre%3BWilliams%2C+Anna%3BPearce%2C+Bruce%3BBeaudoin%2C+Michael%3BBuzatu%2C+Dan&rft.aulast=Holland&rft.aufirst=Ricky&rft.date=2014-12-15&rft.volume=28&rft.issue=23&rft.spage=2617&rft.isbn=&rft.btitle=&rft.title=Rapid+communications+in+mass+spectrometry+%3A+RCM&rft.issn=1097-0231&rft_id=info:doi/10.1002%2Frcm.7060 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-17 N1 - Date created - 2014-11-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/rcm.7060 ER - TY - JOUR T1 - Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type. AN - 1637567786; 25502671 AB - Here we report the genome sequence of a Clostridium botulinum strain IBCA10-7060 producing botulinum neurotoxin serotype B and a new toxin serotype. Multilocus sequence typing analysis revealed that this strain belongs to a new sequence type, and whole-genome single nucleotide polymorphism analysis showed that this strain clustered with strains in lineage 2 from group I. Copyright © 2014 Gonzalez-Escalona et al. JF - Genome announcements AU - Gonzalez-Escalona, Narjol AU - Thirunavukkarasu, Nagarajan AU - Singh, Ajay AU - Toro, Magaly AU - Brown, Eric W AU - Zink, Donald AU - Rummel, Andreas AU - Sharma, Shashi K AD - Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA. ; Office of the Center Director, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA. ; Institut für Toxikologie, Medizinische Hochschule Hannover, Niedersachsen, Germany. ; Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA shashi.sharma@fda.hhs.gov. Y1 - 2014/12/11/ PY - 2014 DA - 2014 Dec 11 VL - 2 IS - 6 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1637567786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+announcements&rft.atitle=Draft+Genome+Sequence+of+Bivalent+Clostridium+botulinum+Strain+IBCA10-7060%2C+Encoding+Botulinum+Neurotoxin+B+and+a+New+FA+Mosaic+Type.&rft.au=Gonzalez-Escalona%2C+Narjol%3BThirunavukkarasu%2C+Nagarajan%3BSingh%2C+Ajay%3BToro%2C+Magaly%3BBrown%2C+Eric+W%3BZink%2C+Donald%3BRummel%2C+Andreas%3BSharma%2C+Shashi+K&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2014-12-11&rft.volume=2&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genome+announcements&rft.issn=&rft_id=info:doi/10.1128%2FgenomeA.01275-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-16 N1 - Date created - 2014-12-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/genomeA.01275-14 ER - TY - JOUR T1 - Liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the direct detection of 2-monochloropropanediol (2-MCPD) esters in edible oils. AN - 1629958067; 25383913 AB - A new analytical method has been developed and validated for the detection and quantification of 2-monochloropropanediol (2-MCPD) esters in edible oils. The target compounds are potentially carcinogenic contaminants formed during the processing of edible oils. As the 2-MCPD esters that occur most frequently in refined edible oils were not commercially available, standards were synthesized with identity and purity (95+%) confirmed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and (1)H NMR. Target analytes are separated from edible oil matrices using a two-step solid-phase extraction (SPE) procedure. The extracts are then analyzed using LC-MS/MS with electrospray ionization (ESI). The method has been validated for 11 2-MCPD diesters and 3 2-MCPD monoesters in soybean oil, olive oil, and palm oil using an external calibration curve. The ranges of average recoveries and relative standard deviations (RSD) across the three oil matrices at three spiking concentrations are 79-106% (3-13% RSD) for the 2-MCPD diesters and 72-108% (4-17% RSD) for the 2-MCPD monoesters, with limits of quantitation at or below 30 ng/g for the diesters and 90 ng/g for the monoesters. JF - Journal of agricultural and food chemistry AU - MacMahon, Shaun AU - Ridge, Clark D AU - Begley, Timothy H AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, College Park, Maryland 20740, United States. Y1 - 2014/12/03/ PY - 2014 DA - 2014 Dec 03 SP - 11647 EP - 11656 VL - 62 IS - 48 KW - 2-monochloropropanediol KW - 0 KW - Carcinogens KW - Esters KW - Olive Oil KW - Plant Oils KW - palm oil KW - 5QUO05548Z KW - Soybean Oil KW - 8001-22-7 KW - Glycerol KW - PDC6A3C0OX KW - Index Medicus KW - 3-MCPD KW - processing contaminants KW - edible oils KW - LC-MS/MS KW - 3-monochloropropanediol KW - 2-MCPD KW - Food Contamination -- analysis KW - Carcinogens -- analysis KW - Solid Phase Extraction KW - Carcinogens -- isolation & purification KW - Esters -- analysis KW - Esters -- isolation & purification KW - Tandem Mass Spectrometry -- methods KW - Glycerol -- analogs & derivatives KW - Glycerol -- analysis KW - Chromatography, High Pressure Liquid -- methods KW - Plant Oils -- analysis KW - Soybean Oil -- analysis KW - Glycerol -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629958067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Liquid+chromatography-tandem+mass+spectrometry+%28LC-MS%2FMS%29+method+for+the+direct+detection+of+2-monochloropropanediol+%282-MCPD%29+esters+in+edible+oils.&rft.au=MacMahon%2C+Shaun%3BRidge%2C+Clark+D%3BBegley%2C+Timothy+H&rft.aulast=MacMahon&rft.aufirst=Shaun&rft.date=2014-12-03&rft.volume=62&rft.issue=48&rft.spage=11647&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf503994m LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-27 N1 - Date created - 2014-12-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/jf503994m ER - TY - JOUR T1 - Enhancement of ICRP's Lung Deposition Model for Pathogenic Bioaerosols AN - 1673389000; PQ0001231763 AB - Terrorist attacks using pathogenic bioaerosols pose a significant public-health threat. Modeling the risk associated with such attacks is valuable from the standpoint of disaster preparedness. To attain greater flexibility in bioterrorism risk modeling, we have developed an open-source lung deposition code based on the International Committee for Radiological Protection (ICRP) Publication 66 (ICRP 1994). This article describes modifications to ICRP's lung deposition model to fit the bioaerosol context and discusses the impact of exposure from a few monodisperse pathogenic toxins such as botulinum toxin, influenza virus, and Bacillus anthracis to infants and adults. As most existing commercial lung deposition codes are not open-source, this code provides users a platform template that can be modified to meet their needs. JF - Aerosol Science & Technology AU - Guha, Suvajyoti AU - Hariharan, Prasanna AU - Myers, Matthew R AD - Division of Applied Mechanics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, Maryland, USA Y1 - 2014/12/02/ PY - 2014 DA - 2014 Dec 02 SP - 1226 EP - 1235 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 48 IS - 12 SN - 0278-6826, 0278-6826 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Aerosols KW - Terrorism KW - Bioaerosols KW - Airborne microorganisms KW - Disasters KW - Bacillus anthracis KW - Bioterrorism KW - Toxins KW - Influenza KW - Pollutant deposition KW - Influenza virus KW - Lung KW - Emergency preparedness KW - Committees KW - Infants KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673389000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aerosol+Science+%26+Technology&rft.atitle=Enhancement+of+ICRP%27s+Lung+Deposition+Model+for+Pathogenic+Bioaerosols&rft.au=Guha%2C+Suvajyoti%3BHariharan%2C+Prasanna%3BMyers%2C+Matthew+R&rft.aulast=Guha&rft.aufirst=Suvajyoti&rft.date=2014-12-02&rft.volume=48&rft.issue=12&rft.spage=1226&rft.isbn=&rft.btitle=&rft.title=Aerosol+Science+%26+Technology&rft.issn=02786826&rft_id=info:doi/10.1080%2F02786826.2014.975334 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2016-02-29 N1 - SubjectsTermNotLitGenreText - Bioaerosols; Disasters; Influenza; Pollutant deposition; Aerosols; Terrorism; Lung; Committees; Emergency preparedness; Airborne microorganisms; Bioterrorism; Toxins; Infants; Influenza virus; Bacillus anthracis DO - http://dx.doi.org/10.1080/02786826.2014.975334 ER - TY - JOUR T1 - Comparison of measured and self-reported anthropometric information among firefighters: implications and applications AN - 1654680096; 21188308 AB - This study evaluated the accuracy of self-reported body weight and height compared to measured values among firefighters and identified factors associated with reporting error. A total of 863 male and 88 female firefighters in four US regions participated in the study. The results showed that both men and women underestimated their body weight ( - 0.4 plus or minus 4.1, - 1.1 plus or minus 3.6 kg) and overestimated their height (29 plus or minus 18 , 17 plus or minus 16 mm). Women underestimated more than men on weight (p = 0.022) and men overestimated more than women on height (p < 0.001). Reporting errors on weight were increased with overweight status (p < 0.001) and were disproportionate among subgroups. About 27% men and 24% women had reporting errors on weight greater than plus or minus 2.2 kg, and 59% men and 28% women had reporting errors on height greater than 25 mm. Practitioner Summary: This study along with literature revealed that the self-reported approach is not a sustainable option for anthropometric surveys, even for gathering data from physically active professional groups, such as firefighters, who presumably are knowledgeable of their body dimensions. Self-reported anthropometric information is undependable in important population subgroups. JF - Ergonomics AU - Hsiao, Hongwei AU - Weaver, Darlene AU - Hsiao, James AU - Whitestone, Jennifer AU - Kau, Tsui-Ying AU - Whisler, Richard AU - Ferri, Robert AD - Division of Safety Research, National Institute for Occupational Safety and Health (NIOSH), Morgantown, WV, USA Y1 - 2014/12/02/ PY - 2014 DA - 2014 Dec 02 SP - 1886 EP - 1897 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 57 IS - 12 SN - 0014-0139, 0014-0139 KW - Sustainability Science Abstracts; Health & Safety Science Abstracts KW - weight KW - height KW - self-reported KW - firefighter KW - anthropometry KW - obesity KW - Obesity KW - Body weight KW - Firefighter services KW - Sustainable development KW - Ergonomics KW - M3 1010:Issues in Sustainable Development KW - H 10000:Ergonomics/Human Factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654680096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ergonomics&rft.atitle=Comparison+of+measured+and+self-reported+anthropometric+information+among+firefighters%3A+implications+and+applications&rft.au=Hsiao%2C+Hongwei%3BWeaver%2C+Darlene%3BHsiao%2C+James%3BWhitestone%2C+Jennifer%3BKau%2C+Tsui-Ying%3BWhisler%2C+Richard%3BFerri%2C+Robert&rft.aulast=Hsiao&rft.aufirst=Hongwei&rft.date=2014-12-02&rft.volume=57&rft.issue=12&rft.spage=1886&rft.isbn=&rft.btitle=&rft.title=Ergonomics&rft.issn=00140139&rft_id=info:doi/10.1080%2F00140139.2014.952351 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Obesity; Body weight; Firefighter services; Sustainable development; Ergonomics DO - http://dx.doi.org/10.1080/00140139.2014.952351 ER - TY - JOUR T1 - Deciphering miRNA transcription factor feed-forward loops to identify drug repurposing candidates for cystic fibrosis AN - 1642618664; 21178582 AB - Cystic fibrosis (CF) is a fatal genetic disorder caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that primarily affects the lungs and the digestive system, and the current drug treatment is mainly able to alleviate symptoms. To improve disease management for CF, we considered the repurposing of approved drugs and hypothesized that specific microRNA (miRNA) transcription factors (TF) gene networks can be used to generate feed-forward loops (FFLs), thus providing treatment opportunities on the basis of disease specific FFLs. Comprehensive database searches revealed significantly enriched TFs and miRNAs in CF and CFTR gene networks. The target genes were validated using ChIPBase and by employing a consensus approach of diverse algorithms to predict miRNA gene targets. STRING analysis confirmed protein-protein interactions (PPIs) among network partners and motif searches defined composite FFLs. Using information extracted from SM2miR and Pharmaco-miR, an in silico drug repurposing pipeline was established based on the regulation of miRNA/TFs in CF/CFTR networks. In human airway epithelium, a total of 15 composite FFLs were constructed based on CFTR specific miRNA/TF gene networks. Importantly, nine of them were confirmed in patient samples and CF epithelial cells lines, and STRING PPI analysis provided evidence that the targets interacted with each other. Functional analysis revealed that ubiquitin-mediated proteolysis and protein processing in the endoplasmic reticulum dominate the composite FFLs, whose major functions are folding, sorting, and degradation. Given that the mutated CFTR gene disrupts the function of the chloride channel, the constructed FFLs address mechanistic aspects of the disease and, among 48 repurposing drug candidates, 26 were confirmed with literature reports and/or existing clinical trials relevant to the treatment of CF patients. The construction of FFLs identified promising drug repurposing candidates for CF and the developed strategy may be applied to other diseases as well. The online version of this article (doi:10.1186/s13073-014-0094-2) contains supplementary material, which is available to authorized users. JF - Genome Medicine AU - Liu, Zhichao AU - Borlak, Juergen AU - Tong, Weida AD - label/>Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079 USA Y1 - 2014/12/02/ PY - 2014 DA - 2014 Dec 02 PB - BioMed Central Ltd., Middlesex House London W1T 4LB United Kingdom VL - 6 IS - 12 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Proteolysis KW - Epithelial cells KW - miRNA KW - Algorithms KW - Chloride channels KW - Cystic fibrosis transmembrane conductance regulator KW - Drug development KW - Clinical trials KW - Computer programs KW - Endoplasmic reticulum KW - Protein folding KW - Lung KW - Transcription factors KW - Epithelium KW - Cystic fibrosis KW - Drugs KW - Mutation KW - Internet KW - Respiratory tract KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642618664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+Medicine&rft.atitle=Deciphering+miRNA+transcription+factor+feed-forward+loops+to+identify+drug+repurposing+candidates+for+cystic+fibrosis&rft.au=Liu%2C+Zhichao%3BBorlak%2C+Juergen%3BTong%2C+Weida&rft.aulast=Liu&rft.aufirst=Zhichao&rft.date=2014-12-02&rft.volume=6&rft.issue=12&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Genome+Medicine&rft.issn=1756-994X&rft_id=info:doi/10.1186%2Fs13073-014-0094-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-01-21 N1 - SubjectsTermNotLitGenreText - Proteolysis; Epithelial cells; miRNA; Algorithms; Cystic fibrosis transmembrane conductance regulator; Chloride channels; Drug development; Clinical trials; Endoplasmic reticulum; Computer programs; Protein folding; Lung; Transcription factors; Epithelium; Mutation; Drugs; Cystic fibrosis; Internet; Respiratory tract DO - http://dx.doi.org/10.1186/s13073-014-0094-2 ER - TY - JOUR T1 - Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity AN - 1868338948; PQ0004058185 AB - Aging is linked to decrease of the body cell use of growth hormone (GH) and thyroxine, whereas the decrease is via "death hormones" inhibition? This study proposes different viewpoints. Since interleukin 17 receptor C (IL17RC) is highly expressed in tissues from age-related macular degeneration (AMD) patients, IL17RC signaling pathways are explored to evaluate Wnts/vascular endothelial growth factor (VEGF) expression and complement activity, which are pathological factors in AMD. IL17RC overexpression or VEGF treatment was performed in two cell lines for up to two-day. Real-time Quantitative PCR, confocal microscopy, immune-blot, MTT assay, etc. measured downstream effects. IL17RC overexpression increases Wnts and VEGF that forms complexes with Wnt-signaling components. VEGF or the Wnt-signaling components interacting with C3 suggests alternative complement pathway activation. Moreover, IL17RC-overexpressed cells or VEGF-treated cells for two-day, which is overstimulation, increase PI3K/Akt/GSK3 insensitivity and GSK3 activity, and decrease growth/survival. High GSK3 activity associates with many chronic diseases including type II Diabetes. This study shows high GSK3 activity can result from PI3K/Akt overstimulation. Type II Diabetes shows insulin resistance that the body cells decrease insulin use. Possessing little sensitive PI3K/Akt for receptor activation, cells after overstimulation, although live, hardly respond to PI3K/Akt activators including GH, thyroxine and insulin. These results suggest an alternative explanation of the body cells declining hormone use since various kinds of cell signaling-induced overstimulation events almost always linked to PI3K/Akt, increase with age. Playing pathological roles in senescence and diseases, overstimulation eventually generates health problems. JF - SpringerPlus AU - Liu, Xunxian AD - US Department of Health and Human Services, Intramural Research Program, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD, 20892, USA, xunxianl@mail.nih.gov Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1 EP - 12 PB - Springer Science & Business Media, Cham VL - 3 IS - 1 KW - Biotechnology and Bioengineering Abstracts KW - Vascular endothelial growth factor KW - Cell survival KW - Growth hormone KW - Wnt protein KW - Receptor mechanisms KW - Interleukin 1 KW - Hormones KW - Insulin KW - Diabetes mellitus KW - 1-Phosphatidylinositol 3-kinase KW - Interleukin 17 KW - Confocal microscopy KW - Complement activation KW - Thyroxine KW - AKT protein KW - Polymerase chain reaction KW - Senescence KW - Complement component C3 KW - Signal transduction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1868338948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=SpringerPlus&rft.atitle=Overstimulation+can+create+health+problems+due+to+increases+in+PI3K%2FAkt%2FGSK3+insensitivity+and+GSK3+activity&rft.au=Liu%2C+Xunxian&rft.aulast=Liu&rft.aufirst=Xunxian&rft.date=2014-12-01&rft.volume=3&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=SpringerPlus&rft.issn=2193-1801&rft_id=info:doi/10.1186%2F2193-1801-3-356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-02-01 N1 - Number of references - 43 N1 - Last updated - 2017-02-15 N1 - SubjectsTermNotLitGenreText - Cell survival; Vascular endothelial growth factor; Growth hormone; Wnt protein; Receptor mechanisms; Interleukin 1; Hormones; Insulin; Diabetes mellitus; 1-Phosphatidylinositol 3-kinase; Interleukin 17; Complement activation; Confocal microscopy; AKT protein; Thyroxine; Polymerase chain reaction; Complement component C3; Senescence; Signal transduction DO - http://dx.doi.org/10.1186/2193-1801-3-356 ER - TY - JOUR T1 - Meteorological influences on nitrogen dynamics of a coastal onsite wastewater treatment system AN - 1812219115; 2016-070054 AB - On-site wastewater treatment systems (OWTS) can contribute nitrogen (N) to coastal waters. In coastal areas with shallow groundwater, OWTS are likely affected by meteorological events. However, the meteorological influences on temporal variability of N exports from OWTS are not well documented. Hydrogeological characterization and seasonal monitoring of wastewater and groundwater quality were conducted at a residence adjacent to the Pamlico River Estuary, North Carolina, during a 2-yr field study (October 2009-2011). Rainfall was elevated during the first study year, relative to the annual mean. In the second year, drought was followed by extreme precipitation from Hurricane Irene. Recent meteorological conditions influenced N speciation and concentrations in groundwater. Groundwater total dissolved nitrogen (TDN) beneath the OWTS drainfield was dominated by nitrate during the drought; during wetter periods, ammonium and organic N were common. Effective precipitation (precipitation [P] minus evapotranspiration [ET]) affected OWTS TDN exports because of its influence on groundwater recharge and discharge. Groundwater nitrate-N concentrations beneath the drainfield were typically higher than 10 mg/L when total biweekly precipitation was less than evapotranspiration (precipitation deficit: P 15 m downgradient of the drainfield. Although OWTS nitrate inputs caused elevated groundwater nitrate concentrations between the drainfield and the estuary, the majority of nitrate was attenuated via denitrification between the OWTS and 48 m to the estuary. However, DON originating from the OWTS was mobile and contributed to elevated TDN concentrations along the groundwater flowpath to the estuary. JF - Journal of Environmental Quality AU - O'Driscoll, M A AU - Humphrey, C P AU - Deal, N E AU - Lindbo, D L AU - Zarate-Bermudez, M A Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1873 EP - 1885 PB - American Society of Agronomy, [and] Crop Science Society of America, [and] Soil Science Society of America, Madison, WI VL - 43 IS - 6 SN - 0047-2425, 0047-2425 KW - water quality KW - waste water KW - halogens KW - preferential flow KW - drought KW - critical load KW - chloride ion KW - Pamlico Sound KW - nitrate ion KW - discharge KW - lysimeters KW - hydrology KW - monitoring KW - nitrous oxide KW - solutes KW - evapotranspiration KW - recharge KW - dissolved oxygen KW - coastal environment KW - seasonal variations KW - United States KW - aquifer vulnerability KW - climatic controls KW - shallow-water environment KW - phytoplankton KW - oxygen KW - ammonium ion KW - Southern Atlantic Coastal Plain KW - plankton KW - nitrogen KW - ground water KW - water treatment KW - estuarine environment KW - water pollution KW - coastal aquifers KW - Atlantic Coastal Plain KW - chlorine KW - concentration KW - drainage KW - pollution KW - resistivity KW - geochemical cycle KW - aquifers KW - nitrification KW - North Carolina KW - bacteria KW - shallow aquifers KW - Hurricane Irene KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1812219115?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Quality&rft.atitle=Meteorological+influences+on+nitrogen+dynamics+of+a+coastal+onsite+wastewater+treatment+system&rft.au=O%27Driscoll%2C+M+A%3BHumphrey%2C+C+P%3BDeal%2C+N+E%3BLindbo%2C+D+L%3BZarate-Bermudez%2C+M+A&rft.aulast=O%27Driscoll&rft.aufirst=M&rft.date=2014-12-01&rft.volume=43&rft.issue=6&rft.spage=1873&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Quality&rft.issn=00472425&rft_id=info:doi/10.2134%2Fjeq2014.05.0227 L2 - https://www.agronomy.org/publications/jeq LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - Number of references - 68 N1 - PubXState - WI N1 - Document feature - illus. incl. 2 tables N1 - Last updated - 2016-08-18 N1 - CODEN - JEVQAA N1 - SubjectsTermNotLitGenreText - ammonium ion; aquifer vulnerability; aquifers; Atlantic Coastal Plain; bacteria; chloride ion; chlorine; climatic controls; coastal aquifers; coastal environment; concentration; critical load; discharge; dissolved oxygen; drainage; drought; estuarine environment; evapotranspiration; geochemical cycle; ground water; halogens; Hurricane Irene; hydrology; lysimeters; monitoring; nitrate ion; nitrification; nitrogen; nitrous oxide; North Carolina; oxygen; Pamlico Sound; phytoplankton; plankton; pollution; preferential flow; recharge; resistivity; seasonal variations; shallow aquifers; shallow-water environment; solutes; Southern Atlantic Coastal Plain; United States; waste water; water pollution; water quality; water treatment DO - http://dx.doi.org/10.2134/jeq2014.05.0227 ER - TY - JOUR T1 - Review of Bayesian statistical analysis methods for cytogenetic radiation biodosimetry, with a practical example AN - 1808691752; PQ0003214462 AB - Classical methods of assessing the uncertainty associated with radiation doses estimated using cytogenetic techniques are now extremely well defined. However, several authors have suggested that a Bayesian approach to uncertainty estimation may be more suitable for cytogenetic data, which are inherently stochastic in nature. The Bayesian analysis framework focuses on identification of probability distributions (for yield of aberrations or estimated dose), which also means that uncertainty is an intrinsic part of the analysis, rather than an 'afterthought'. In this paper Bayesian, as well as some more advanced classical, data analysis methods for radiation cytogenetics are reviewed that have been proposed in the literature. A practical overview of Bayesian cytogenetic dose estimation is also presented, with worked examples from the literature. JF - Radiation Protection Dosimetry AU - Ainsbury, Elizabeth A AU - Vinnikov, Volodymyr A AU - Puig, Pedro AU - Higueras, Manuel AU - Maznyk, Nataliya A AU - Lloyd, David C AU - Rothkamm, Kai AD - Public Health England Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon OX11 0RQ, UK, liz.ainsbury@phe.gov.uk Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 185 EP - 196 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 162 IS - 3 SN - 0144-8420, 0144-8420 KW - Toxicology Abstracts; Environment Abstracts KW - Data processing KW - Radiation KW - Bayesian analysis KW - Reviews KW - Dosimetry KW - Statistical analysis KW - Stochasticity KW - X 24300:Methods KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808691752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Review+of+Bayesian+statistical+analysis+methods+for+cytogenetic+radiation+biodosimetry%2C+with+a+practical+example&rft.au=Ainsbury%2C+Elizabeth+A%3BVinnikov%2C+Volodymyr+A%3BPuig%2C+Pedro%3BHigueras%2C+Manuel%3BMaznyk%2C+Nataliya+A%3BLloyd%2C+David+C%3BRothkamm%2C+Kai&rft.aulast=Ainsbury&rft.aufirst=Elizabeth&rft.date=2014-12-01&rft.volume=162&rft.issue=3&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fnct301 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Data processing; Radiation; Bayesian analysis; Reviews; Dosimetry; Statistical analysis; Stochasticity DO - http://dx.doi.org/10.1093/rpd/nct301 ER - TY - RPRT T1 - Child and Family Development Research. OPRE Report 2014-89 AN - 1773223127; ED558535 AB - This catalog provides short descriptions of major Division of Child and Family Development (DCFD) projects from Fiscal Year 2014. Multiple projects are described in the areas of child care, Head Start/Early Head Start, child welfare promotion, and the recognition of cultural diversity. An additional section features projects that fall into more than one of the aforementioned categories Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 23 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - ERIC, Resources in Education (RIE) KW - Preschool Education KW - Early Childhood Education KW - Measures (Individuals) KW - Employed Parents KW - Research Projects KW - Child Care KW - National Surveys KW - Child Welfare KW - Emotional Development KW - Family School Relationship KW - Child Development KW - Disadvantaged Youth KW - Social Development KW - Cultural Differences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773223127?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - Impacts of Social-Emotional Curricula on Three-Year-Olds: Exploratory Findings from the Head Start CARES Demonstration. OPRE Report 2014-78 AN - 1773213605; ED558517 AB - Preschool has long been viewed as a way to promote low-income children's early learning and development. Some promising classroom-based strategies have been found to enhance preschool children's social, emotional, and behavioral competencies. Most of this research has focused on 4-year-olds, even as a growing number of 3-year-olds attend Head Start and other preschool programs. This report presents exploratory impact findings for 3-year-olds from the Head Start CARES demonstration, a large-scale randomized controlled trial implemented in Head Start centers for one academic year across the country. The goal was to test the effects of three distinct classroom-based program "enhancements" for improving children's social-emotional competencies. The Incredible Years Teacher Training Program supports children's ability to regulate their behavior by helping teachers maintain an organized classroom. Preschool PATHS uses structured lessons to help children learn about emotions and gain social problem-solving skills. Tools of the Mind--Play, a one-year program adapted from the original two-year Tools of the Mind program, promotes children's self-regulatory skills through structured make-believe play. Head Start centers were randomly assigned to receive one of the enhancements or to a control group that did not receive any of them. The study was designed primarily to test the effects of the enhancements on 4-year-olds, but it also provides an opportunity to explore their impacts on a limited number of outcomes for 3-year-olds who were in the classrooms that included both 3- and 4-year-olds. The analysis tested whether the social-emotional enhancements as a group improved 3-year-olds' social and emotional competencies, as well as the impacts of each enhancement separately, based on their distinct theories of change. Key findings in this study include: (1) As a group, the enhancements improved teachers' social-emotional instruction and improved teacher reports of 3-year-olds' social behaviors and closeness with their teachers. However, they had no effect on other aspects of teacher practice, classroom climate, or children's behavior problems, interpersonal skills, or learning behaviors. (2) The positive impacts of the enhancements as a group seem to be driven primarily by The Incredible Years. When considered separately, The Incredible Years improved teacher reports of 3-year-olds' social behaviors and closeness with their teachers, though it did not produce the expected impacts on teachers' use of classroom management practices or on classroom climate. (3) As a group, the enhancements did not affect 3-year-olds' pre-academic skills, as reported by teachers. The Incredible Years improved teacher reports of 3-year-olds' general knowledge, language and literacy, and mathematical thinking skills. However, the findings are uncertain because The Incredible Years also improved 4-year-olds' pre-academic skills as reported by teachers, but not as measured by direct assessments. These findings suggest that evidence-based approaches can improve 3-year-olds' social-emotional competence in mixed-age preschool classrooms. While the findings are promising, further research is needed to confirm the results and to better understand how these benefits are generated. The following are appended: (1) Sample Selection, Recruitment, and Random Assignment in Head Start CARES; (2) Baseline Equivalence of Teachers, Classrooms, and Children Across Program and Control Groups; (3) Sensitivity Analyses: Child-Level Impacts Controlling for Baseline Differences; (4) Measures Used in Head Start CARES Impact Analysis of 3-Year-Olds; (5) Model Specifications; (6) Attrition and Turnover Analyses; and (7) Glossary. [For the executive summary of this report, see ED558515.] AU - Hsueh, JoAnn AU - Lowenstein, Amy E. AU - Morris, Pamela AU - Mattera, Shira K. AU - Bangser, Michael Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 142 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - United States (Midwest) KW - United States (West) KW - United States (South) KW - Student Teacher Relationship Scale KW - Social Skills Rating System KW - Maslach Burnout Inventory KW - ERIC, Resources in Education (RIE) KW - Preschool Education KW - Early Childhood Education KW - Mixed Age Grouping KW - Thinking Skills KW - Program Effectiveness KW - Teacher Student Relationship KW - Classroom Environment KW - Student Characteristics KW - Mathematics Skills KW - Teacher Competencies KW - Comparative Analysis KW - Academic Ability KW - At Risk Students KW - Knowledge Level KW - Statistical Analysis KW - Emergent Literacy KW - Disadvantaged Youth KW - Social Development KW - Preschool Children KW - Effect Size KW - Age Differences KW - Teaching Methods KW - Measures (Individuals) KW - Play KW - Teacher Characteristics KW - Language Skills KW - Reading Skills KW - Social Behavior KW - Experimental Groups KW - Behavior Problems KW - Emotional Development KW - Problem Solving KW - Burnout KW - Control Groups KW - Interpersonal Competence KW - Theories KW - Early Intervention KW - Likert Scales KW - Faculty Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773213605?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Stress-release seismic source for seismic velocity measurement in mines AN - 1769963318; 2016-018220 AB - Accurate seismic event locations are needed to delineate roles of mine geometry, stress and geologic structures in developing rockburst conditions. Accurate absolute locations are challenging in mine environments with rapid changes in seismic velocity due to sharp contrasts between individual layers and large time-dependent velocity gradients attending excavations. Periodic use of controlled seismic sources can help constrain the velocity in this continually evolving propagation medium comprising the miners' workplace. With a view to constructing realistic velocity models in environments in which use of explosives is problematic, a seismic source was developed subject to the following design constraints: (i) suitable for use in highly disturbed zones surrounding mine openings, (ii) able to produce usable signals over km-scale distances in the frequency range of typical coal mine seismic events ( approximately 10-100 Hz), (iii) repeatable, (iv) portable, (v) non-disruptive to mining operations, and (vi) safe for use in potentially explosive gaseous environments. Designs of the compressed load column seismic source (CLCSS), which generates a stress, or load, drop normal to the surface of mine openings, and the fiber-optic based source-initiation timer are presented. Tests were conducted in a coal mine at a depth of 500 m (1700 ft) and signals were recorded on the surface with a 72-ch (14 Hz) exploration seismograph for load drops of 150-470 kN (16-48 tons). Signal-to-noise ratios of unfiltered signals ranged from approximately 200 immediately above the source (500 m (1700 ft)) to approximately 8 at the farthest extent of the array (slant distance of approximately 800 m (2600 ft)), suggesting the potential for use over longer range. Results are compared with signals produced by weight drop and sledge hammer sources, indicating the superior waveform quality for first-arrival measurements with the CLCSS seismic source. JF - American Geophysical Union Fall Meeting AU - Swanson, P L AU - Clark, C AU - Richardson, J AU - Martin, L AU - Zahl, E AU - Etter, A AU - Anonymous Y1 - 2014/12// PY - 2014 DA - December 2014 SP - Abstract S23C EP - 4508 PB - American Geophysical Union, Washington, DC VL - 2014 KW - 19:Seismology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1769963318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Geophysical+Union+Fall+Meeting&rft.atitle=Stress-release+seismic+source+for+seismic+velocity+measurement+in+mines&rft.au=Swanson%2C+P+L%3BClark%2C+C%3BRichardson%2C+J%3BMartin%2C+L%3BZahl%2C+E%3BEtter%2C+A%3BAnonymous&rft.aulast=Swanson&rft.aufirst=P&rft.date=2014-12-01&rft.volume=2014&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=American+Geophysical+Union+Fall+Meeting&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - American Geophysical Union 2014 fall meeting N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data supplied by, and/or abstract, Copyright, American Geophysical Union, Washington, DC, United States N1 - Date revised - 2016-01-01 N1 - PubXState - DC N1 - Last updated - 2016-03-03 N1 - CODEN - #07548 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF COBALT METAL (CAS NO. 7440-48-4) IN F344/N RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF COBALT METAL IN F344/NTac RATS AND B6C3F1/N MICE (INHALATION STUDIES) AN - 1732068371 AB - Cobalt metal is used in the production of alloys, in nuclear medicine, and as a catalyst in organic reactions. Exposure to cobalt metal dust occurs in a variety of metalworking occupations. We exposed groups of 50 male and female rats and mice to atmospheres containing aerosols of 1.25, 2.5, or 5 mg of cobalt metal particles per cubic meter of air. Similar groups of animals exposed to clean air in the same type of inhalation chambers served as the control groups. Animals were exposed 6 hours per day, 5 days per week for 2 years. Tissues from more than 40 sites were examined for every animal. All groups of male and female rats and mice exposed to cobalt metal had markedly increased incidences of lung neoplasms compared to the control groups. Other lesions of the respiratory tract included inflammation, fibrosis, and hyperplasia of the nose and lung in male and female rats and mice and lesions in the larynx and trachea in male and female mice. There were also increased incidences of pheochromocytomas of the adrenal medulla in male and female rats and tumors in the pancreatic islets in male rats. We conclude that exposure to cobalt metal particles caused lung neoplasms in male and female rats and mice. A spectrum of other nonneoplastic lesions in the respiratory tract of male and female rats and mice were caused by cobalt metal exposure. Cancers of the adrenal medulla in male and female rats and pancreatic islets in male rats were also attributed to cobalt metal exposure. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1 EP - 19,21-41,43-107,109-155,157-203,205-211,213-239,241-269,271-287,289-297 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Cobalt KW - Toxicology KW - Rodents KW - Carcinogens KW - Human exposure KW - Lung diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732068371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+COBALT+METAL+%28CAS+NO.+7440-48-4%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+COBALT+METAL+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+%28INHALATION+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-12-01&rft.volume=&rft.issue=581&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2014 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-11-10 ER - TY - RPRT T1 - FOREWORD AN - 1732068355 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732068355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-12-01&rft.volume=&rft.issue=581&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2014 N1 - Last updated - 2015-11-10 ER - TY - RPRT T1 - Table of contents AN - 1732068335 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1732068335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-12-01&rft.volume=&rft.issue=581&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Dec 2014 N1 - Last updated - 2015-11-10 ER - TY - JOUR T1 - Comprehensive analysis of alterations in lipid and bile acid metabolism by carbon tetrachloride using integrated transcriptomics and metabolomics AN - 1709184752; 20926333 AB - Understanding mechanisms of liver injury can enable better preclinical testing and clinical management of patients. Carbon tetrachloride (CCl sub(4)), used extensively as a model hepatotoxicant, induces lipid perturbation and increases in plasma bile acids (BAs). An integrated transcriptomics and metabolomics approach was employed to investigate CCl sub(4)-induced alterations in lipid and BA metabolism. Sprague-Dawley rats were treated orally with corn oil, 50 (low dose, LD) or 2,000 mg CCl sub(4)/kg/d (high dose, HD). Animals were sacrificed at 6, 24 or 72 h. Terminal blood was collected for clinical chemistry and metabolomics analyses. Livers were harvested for histopathology, metabolomics and transcriptomics analyses. Both alanine aminotransferase (ALT) and aspartate aminotransferase (AST) increased in the treated groups with the greatest increases observed in the HD group at 24 and 72 h. Blood cholesterol and triglycerides (TGs) were significantly decreased in the HD group at both 24 and 72 h, and hepatocyte vacuolization was observed at these timepoints. Consistent with the clinical chemistry and histopathological data, metabolomics results showed that levels of total fatty acids increased in the liver but decreased in the blood in the HD group at the 24 and 72 h timepoints. This suggested that lipids accumulate in the liver. Primary BAs increased in both liver and blood, while secondary and conjugated BAs decreased in the liver and increased in the blood, which indicated that the BA conjugation pathway and that BA uptake by the liver were inhibited by CCl sub(4). Results from this study provide a better understanding of the mechanisms of CCl sub(4)-induced hepatotoxicity. JF - Metabolomics AU - Sun, Jinchun AU - Schmitt, Thomas AU - Schnackenberg, Laura K AU - Pence, Lisa AU - Ando, Yosuke AU - Greenhaw, James AU - Yang, Xi AU - Slavov, Svetoslav AU - Davis, Kelly AU - Salminen, William F AU - Mendrick, Donna L AU - Beger, Richard D AD - Division of Systems Biology, National Center for Toxicological Research, US FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA, Jinchun.Sun@fda.hhs.gov Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1293 EP - 1304 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 10 IS - 6 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Injuries KW - Hepatocytes KW - Aspartate aminotransferase KW - Lipids KW - Cholesterol KW - Alanine transaminase KW - hepatotoxicity KW - Lipid metabolism KW - Models KW - Oil KW - Blood KW - Carbon tetrachloride KW - Triglycerides KW - Bile acids KW - Fatty acids KW - Liver KW - Metabolism KW - metabolomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709184752?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Comprehensive+analysis+of+alterations+in+lipid+and+bile+acid+metabolism+by+carbon+tetrachloride+using+integrated+transcriptomics+and+metabolomics&rft.au=Sun%2C+Jinchun%3BSchmitt%2C+Thomas%3BSchnackenberg%2C+Laura+K%3BPence%2C+Lisa%3BAndo%2C+Yosuke%3BGreenhaw%2C+James%3BYang%2C+Xi%3BSlavov%2C+Svetoslav%3BDavis%2C+Kelly%3BSalminen%2C+William+F%3BMendrick%2C+Donna+L%3BBeger%2C+Richard+D&rft.aulast=Sun&rft.aufirst=Jinchun&rft.date=2014-12-01&rft.volume=10&rft.issue=6&rft.spage=1293&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-014-0665-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 28 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Data processing; Injuries; Aspartate aminotransferase; Hepatocytes; Lipids; Cholesterol; Alanine transaminase; hepatotoxicity; Models; Lipid metabolism; Oil; Blood; Carbon tetrachloride; Triglycerides; Bile acids; Liver; Fatty acids; metabolomics; Metabolism DO - http://dx.doi.org/10.1007/s11306-014-0665-7 ER - TY - JOUR T1 - Trends in antibiotic prescribing in primary care for clinical syndromes subject to national recommendations to reduce antibiotic resistance, UK 1995-2011: analysis of a large database of primary care consultations AN - 1701493916; PQ0001800745 AB - Objectives To measure trends in antibiotic prescribing in UK primary care in relation to nationally recommended best practice. Patients and methods A descriptive study linking individual patient data on diagnosis and prescription in a large primary care database, covering 537 UK general practices during 1995-2011. Results The proportion of cough/cold episodes for which antibiotics were prescribed decreased from 47% in 1995 to 36% in 1999, before increasing to 51% in 2011. There was marked variation by primary care practice in 2011 [10th-90th percentile range (TNPR) 32%-65%]. Antibiotic prescribing for sore throats fell from 77% in 1995 to 62% in 1999 and then stayed broadly stable (TNPR 45%-78%). Where antibiotics were prescribed for sore throat, recommended antibiotics were used in 69% of cases in 2011 (64% in 1995). The use of recommended short-course trimethoprim for urinary tract infection (UTI) in women aged 16-74 years increased from 8% in 1995 to 50% in 2011; however, a quarter of practices prescribed short courses in less than or equal to 16% of episodes in 2011. For otitis media, 85% of prescriptions were for recommended antibiotics in 2011, increasing from 77% in 1995. All these changes in annual prescribing were highly statistically significant (P<0.001). Conclusions The implementation of national guidelines in UK primary care has had mixed success, with prescribing for coughs/colds, both in total and as a proportion of consultations, now being greater than before recommendations were made to reduce it. Extensive variation by practice suggests that there is significant scope to improve prescribing, particularly for coughs/colds and for UTIs. JF - Journal of Antimicrobial Chemotherapy AU - Hawker, Jeremy I AU - Smith, Sue AU - Smith, Gillian E AU - Morbey, Roger AU - Johnson, Alan P AU - Fleming, Douglas M AU - Shallcross, Laura AU - Hayward, Andrew C Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 3423 EP - 3430 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 69 IS - 12 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - antibiotic prescribing KW - primary care KW - surveillance trends KW - respiratory tract infections KW - otitis media KW - urinary tract infections KW - Databases KW - Trimethoprim KW - Data processing KW - Otitis media KW - Statistical analysis KW - Cough KW - Antibiotics KW - Pharyngitis KW - Urinary tract KW - Infection KW - Antibiotic resistance KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1701493916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Trends+in+antibiotic+prescribing+in+primary+care+for+clinical+syndromes+subject+to+national+recommendations+to+reduce+antibiotic+resistance%2C+UK+1995-2011%3A+analysis+of+a+large+database+of+primary+care+consultations&rft.au=Hawker%2C+Jeremy+I%3BSmith%2C+Sue%3BSmith%2C+Gillian+E%3BMorbey%2C+Roger%3BJohnson%2C+Alan+P%3BFleming%2C+Douglas+M%3BShallcross%2C+Laura%3BHayward%2C+Andrew+C&rft.aulast=Hawker&rft.aufirst=Jeremy&rft.date=2014-12-01&rft.volume=69&rft.issue=12&rft.spage=3423&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdku291 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Databases; Trimethoprim; Data processing; Otitis media; Statistical analysis; Cough; Antibiotics; Urinary tract; Pharyngitis; Infection; Antibiotic resistance DO - http://dx.doi.org/10.1093/jac/dku291 ER - TY - JOUR T1 - External Quality Assessments for Microbiologic Diagnosis of Diphtheria in Europe AN - 1694975017; 21154729 AB - The European Diphtheria Surveillance Network (EDSN) ensures the reliable epidemiological and microbiologic assessment of disease prevalence in the European Union. Here, we describe a survey of current diagnostic techniques for diphtheria surveillance conducted across the European Union and report the results from three external quality assessment (EQA) schemes performed between 2010 and 2014. JF - Journal of Clinical Microbiology AU - Both, Leonard AU - Neal, Shona AU - Zoysa, Aruni De AU - Mann, Ginder AU - Czumbel, Ida AD - WHO Global Collaborating Centre for Reference and Research on Diphtheria and Streptococcal Infections, Public Health England (PHE), London, United Kingdom, androulla.efstratiou@phe.gov.uk. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 4381 EP - 4384 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 52 IS - 12 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Quality control KW - Diphtheria KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1694975017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=External+Quality+Assessments+for+Microbiologic+Diagnosis+of+Diphtheria+in+Europe&rft.au=Both%2C+Leonard%3BNeal%2C+Shona%3BZoysa%2C+Aruni+De%3BMann%2C+Ginder%3BCzumbel%2C+Ida&rft.aulast=Both&rft.aufirst=Leonard&rft.date=2014-12-01&rft.volume=52&rft.issue=12&rft.spage=4381&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.01776-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-07-01 N1 - Number of references - 13 N1 - Last updated - 2016-07-20 N1 - SubjectsTermNotLitGenreText - Quality control; Diphtheria DO - http://dx.doi.org/10.1128/JCM.01776-14 ER - TY - JOUR T1 - Perceived HIV Status is a Key Determinant of Unprotected Anal Intercourse Within Partnerships of Men Who Have Sex With Men in Amsterdam AN - 1680149299; 201503008 AB - The practice of unprotected anal intercourse (UAI) involves at least two partners. We examined the associations between insertive or receptive UAI and perceived HIV seroconcordance and partnership type in self-perceived HIV-negative and self-perceived HIV-positive men who have sex with men (MSM). MSM (age >= 18 years) were recruited for a cross-sectional survey at the sexually transmitted infections clinic in Amsterdam, the Netherlands, in 2008-2009. Participants completed a questionnaire concerning partnerships in the preceding 6 months. Associations were quantified via multinomial logistic regression models using generalized estimating equations. The outcomes were 'no, or safe anal intercourse', 'insertive UAI', and 'receptive UAI'. We included 5,456 partnerships from 1,890 self-perceived HIV-negative men and 1,861 partnerships from 558 self-perceived HIV-positive men. Within the partnerships, perceived HIV status of the partner was an important determinant of UAI (p < 0.001). Among HIV-negative men, perceived HIV discordance was negatively associated with receptive UAI compared with no or safe UAI (OR 0.57; 95 % CI 0.36-0.92); when the partners were more familiar with each other, the risk of receptive UAI was increased relative to no or safe anal intercourse. Among HIV-positive men, perceived HIV discordance was negatively associated with insertive UAI (OR 0.05; 95 % CI 0.03-0.08). Within partnerships, perceived HIV status of the partner was one of the strongest determinants of UAI among self-perceived HIV-negative and HIV-positive MSM, and discordant serostatus was negatively associated with UAI. The findings suggest that serosorting is one of the main strategies when engaging in UAI. Adapted from the source document. JF - AIDS and Behavior AU - Matser, Amy AU - Heijman, Titia AU - Geskus, Ronald AU - Vries, Henry AU - Kretzschmar, Mirjam AU - Speksnijder, Arjen AU - Xiridou, Maria AU - Fennema, Han AU - Schim van der Loeff, Maarten AD - Department of Research, Cluster of Infectious Diseases, Public Health Service of Amsterdam, Postbox 2200, 1000 CE, Amsterdam, The Netherlands amatser@ggd.amsterdam.nl Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 2442 EP - 2456 PB - Springer, Dordrecht, The Netherlands VL - 18 IS - 12 SN - 1090-7165, 1090-7165 KW - Risk KW - Males KW - Acquired Immune Deficiency Syndrome KW - Venereal Diseases KW - Sexual Intercourse KW - Homosexuality KW - Netherlands KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680149299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=Perceived+HIV+Status+is+a+Key+Determinant+of+Unprotected+Anal+Intercourse+Within+Partnerships+of+Men+Who+Have+Sex+With+Men+in+Amsterdam&rft.au=Matser%2C+Amy%3BHeijman%2C+Titia%3BGeskus%2C+Ronald%3BVries%2C+Henry%3BKretzschmar%2C+Mirjam%3BSpeksnijder%2C+Arjen%3BXiridou%2C+Maria%3BFennema%2C+Han%3BSchim+van+der+Loeff%2C+Maarten&rft.aulast=Matser&rft.aufirst=Amy&rft.date=2014-12-01&rft.volume=18&rft.issue=12&rft.spage=2442&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-014-0819-7 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-05-01 N1 - Number of references - 41 N1 - Last updated - 2016-09-28 N1 - CODEN - AIBEFC N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Homosexuality; Males; Sexual Intercourse; Netherlands; Risk; Venereal Diseases DO - http://dx.doi.org/10.1007/s10461-014-0819-7 ER - TY - JOUR T1 - In Liberia, the End of the Ebola Epidemic will be the Beginning AN - 1673389001; PQ0001356794 JF - EcoHealth AU - Said, Maria AD - LCDR, United States Public Health Service, Washington, DC, USA, said.maria@gmail.com Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 459 EP - 460 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 11 IS - 4 SN - 1612-9202, 1612-9202 KW - Ecology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673389001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EcoHealth&rft.atitle=In+Liberia%2C+the+End+of+the+Ebola+Epidemic+will+be+the+Beginning&rft.au=Said%2C+Maria&rft.aulast=Said&rft.aufirst=Maria&rft.date=2014-12-01&rft.volume=11&rft.issue=4&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=EcoHealth&rft.issn=16129202&rft_id=info:doi/10.1007%2Fs10393-015-1017-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-04-01 N1 - Last updated - 2015-11-16 DO - http://dx.doi.org/10.1007/s10393-015-1017-4 ER - TY - JOUR T1 - Facing the Recession: How Did Safety‐Net Hospitals Fare Financially Compared with Their Peers? AN - 1665156553 AB - 1,453 urban, nonfederal, general acute hospitals in 32 states with complete data. JF - Health Services Research AU - Reiter, Kristin L AU - Jiang, H Joanna AU - Wang, Jia AD - The University of North Carolina at Chapel Hill ; Agency for Healthcare Research and Quality. Center for Delivery, Organization, and Markets ; Data and Analytic Solutions, Inc. ; The University of North Carolina at Chapel Hill Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1747 EP - 1766 CY - Chicago PB - Wiley Subscription Services, Inc. VL - 49 IS - 6 SN - 0017-9124 KW - Medical Sciences KW - Economic recession KW - Hospitals KW - Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665156553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Facing+the+Recession%3A+How+Did+Safety%E2%80%90Net+Hospitals+Fare+Financially+Compared+with+Their+Peers%3F&rft.au=Reiter%2C+Kristin+L%3BJiang%2C+H+Joanna%3BWang%2C+Jia&rft.aulast=Reiter&rft.aufirst=Kristin&rft.date=2014-12-01&rft.volume=49&rft.issue=6&rft.spage=1747&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12230 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-12 DO - http://dx.doi.org/10.1111/1475-6773.12230 ER - TY - JOUR T1 - Physical and Mental Health Status of Iraqi Refugees Resettled in the United States AN - 1665156289 AB - We conducted a survey among Iraqi refugees resettled in the United States to assess their physical and mental health status and healthcare access and utilization following the initial 8-month, post-arrival period. We randomly selected Iraqi refugees: ≥18 years of age; living in the United States for 8–36 months; and residents of Michigan, California, Texas and Idaho. Participants completed a household questionnaire and mental health assessment. We distributed 366 surveys. Seventy-five percent of participants had health insurance at the time of the survey; 43 % reported delaying or not seeking care for a medical problem in the past year. Sixty percent of participants reported one chronic condition; 37 % reported ≥2 conditions. The prevalence of emotional distress, anxiety, and depression was approximately 50 % of participants; 31 % were at risk for post-traumatic stress disorder. Iraqi refugees in this evaluation reported a high prevalence of chronic conditions and mental health symptoms despite relatively high access to healthcare. It is important for resettlement partners to be aware of the distinctive health concerns of this population to best address needs within this community. JF - Journal of Immigrant and Minority Health AU - Taylor, Eboni M AU - Yanni, Emad A AU - Pezzi, Clelia AU - Guterbock, Michael AU - Rothney, Erin AU - Harton, Elizabeth AU - Montour, Jessica AU - Elias, Collin AU - Burke, Heather AD - Epidemic Intelligence Service, Immigrant, Refugee, and Migrant Health Branch, Division of Global Migration and Quarantine, US Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mail-stop E-03, Atlanta, GA, 30333, USA, United States Public Health Service, Washington, DC, USA ; Immigrant, Refugee, and Migrant Health Branch, Division of Global Migration and Quarantine, CDC, Atlanta, GA, USA ; Division of Global Migration and Quarantine, US Centers for Disease Control and Prevention, San Diego, CA, USA ; Division of Global Migration and Quarantine, US Centers for Disease Control and Prevention, Detroit, MI, USA ; Refugee Health Program, Texas Department of State Health Services, Austin, TX, USA ; Refugee Health Screening Program, Idaho Department of Health and Welfare, Boise, ID, USA ; Epidemic Intelligence Service, Immigrant, Refugee, and Migrant Health Branch, Division of Global Migration and Quarantine, US Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mail-stop E-03, Atlanta, GA, 30333, USA; United States Public Health Service, Washington, DC, USA Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1130 EP - 1137 CY - New York PB - Springer Science & Business Media VL - 16 IS - 6 SN - 1557-1912 KW - Medical Sciences KW - Anxiety-Depression KW - Conditions KW - Refugees KW - Resettlement KW - Risk assessment KW - Traumatic stress KW - At risk KW - Chronic sickness KW - Depression KW - Emotional distress KW - Health KW - Health care KW - Health insurance KW - Health problems KW - Health status KW - Insurance KW - Mental health KW - Mental illness KW - Posttraumatic stress disorder KW - Psychological distress KW - California KW - Idaho KW - Texas KW - United States--US KW - Michigan KW - Iraq UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665156289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immigrant+and+Minority+Health&rft.atitle=Physical+and+Mental+Health+Status+of+Iraqi+Refugees+Resettled+in+the+United+States&rft.au=Taylor%2C+Eboni+M%3BYanni%2C+Emad+A%3BPezzi%2C+Clelia%3BGuterbock%2C+Michael%3BRothney%2C+Erin%3BHarton%2C+Elizabeth%3BMontour%2C+Jessica%3BElias%2C+Collin%3BBurke%2C+Heather&rft.aulast=Taylor&rft.aufirst=Eboni&rft.date=2014-12-01&rft.volume=16&rft.issue=6&rft.spage=1130&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immigrant+and+Minority+Health&rft.issn=15571912&rft_id=info:doi/10.1007%2Fs10903-013-9893-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright Springer Science & Business Media Dec 2014 N1 - Date revised - 2015-01-09 N1 - Last updated - 2017-02-08 N1 - SubjectsTermNotLitGenreText - California; Idaho; Iraq; Michigan; Texas; United States--US DO - http://dx.doi.org/10.1007/s10903-013-9893-6 ER - TY - JOUR T1 - Regional use of the Australian Chronic Disease Dental Scheme AN - 1665152661 AB - Australia. JF - The Australian Journal of Rural Health AU - Kraatz, Jennifer AU - Qin, Daiyo AU - Hoang, Ha AU - Godwin, Diana AU - Crocombe, Leonard A AD - Centre for Rural Health School of Health Sciences. University of Tasmania, Oral Health Services Tasmania. Tasmanian Department of Health and Human Services ; Centre for Rural Health School of Health Sciences. University of Tasmania ; Centre for Rural Health School of Health Sciences. University of Tasmania, Australian Research Centre for Population Oral Health, School of Dentistry. University of Adelaide, School of Dentistry. University of Western Australia ; Centre for Rural Health School of Health Sciences. University of Tasmania; Oral Health Services Tasmania. Tasmanian Department of Health and Human Services Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 310 EP - 315 CY - Richmond PB - Wiley Subscription Services, Inc. VL - 22 IS - 6 SN - 1038-5282 KW - Medical Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665152661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Australian+Journal+of+Rural+Health&rft.atitle=Regional+use+of+the+Australian+Chronic+Disease+Dental+Scheme&rft.au=Kraatz%2C+Jennifer%3BQin%2C+Daiyo%3BHoang%2C+Ha%3BGodwin%2C+Diana%3BCrocombe%2C+Leonard+A&rft.aulast=Kraatz&rft.aufirst=Jennifer&rft.date=2014-12-01&rft.volume=22&rft.issue=6&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=The+Australian+Journal+of+Rural+Health&rft.issn=10385282&rft_id=info:doi/10.1111%2Fajr.12121 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2015-12-14 DO - http://dx.doi.org/10.1111/ajr.12121 ER - TY - JOUR T1 - The use of Aspergillus niger cultures for biotransformation of terpenoids AN - 1664213480; PQ0001186556 AB - Aspergillus niger is a well-known fungus that has been used for many different biotransformations of organic compounds. The terpenoids include a large variety of natural hydrocarbons and their derivatives, mostly obtained from plant essential oils, but some obtained from animals or fungi. They may be acyclic or have one or more rings of various sizes, and they show a variety of biological activities that include antibacterial, antifungal, antiparasitic, antiviral, and anticancer activities. Terpenoids are classified as monoterpenoids (C sub(10)), sesquiterpenoids (C sub(15)), diterpenoids (C sub(20)), triterpenoids (C sub(30)), and others. This review summarizes experimental processes that use cultures of various A. niger strains to carry out stereoselective biochemical reactions in terpenoids, including related epoxides, lactones, N-phenylcarbamates, and saponins, to produce metabolites that may be useful as flavors and fragrances or as new experimental drug candidates. Cultures of A. niger that add hydroxyl, carbonyl, and other groups at specific positions or reduce double bonds have resulted in the production of valuable new compounds. JF - Process Biochemistry AU - Parshikov, Igor A AU - Sutherland, John B AD - Institute of Applied Mechanics, Russian Academy of Sciences, Moscow 119991, Russia, john.sutherland@fda.hhs.gov Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 2086 EP - 2100 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 49 IS - 12 SN - 1359-5113, 1359-5113 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Aspergillus niger KW - Biotransformation KW - Epoxides KW - Saponins KW - Terpenes KW - triterpenoids KW - Flavor KW - Hydrocarbons KW - Fungi KW - diterpenes KW - biotransformation KW - Metabolites KW - Drug development KW - lactones KW - sesquiterpenoids KW - Essential oils KW - monoterpenoids KW - Organic compounds KW - Fragrances KW - carbonyls KW - Antitumor activity KW - W 30950:Waste Treatment & Pollution Clean-up KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664213480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Process+Biochemistry&rft.atitle=The+use+of+Aspergillus+niger+cultures+for+biotransformation+of+terpenoids&rft.au=Parshikov%2C+Igor+A%3BSutherland%2C+John+B&rft.aulast=Parshikov&rft.aufirst=Igor&rft.date=2014-12-01&rft.volume=49&rft.issue=12&rft.spage=2086&rft.isbn=&rft.btitle=&rft.title=Process+Biochemistry&rft.issn=13595113&rft_id=info:doi/10.1016%2Fj.procbio.2014.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - triterpenoids; Epoxides; Flavor; Hydrocarbons; diterpenes; Fungi; biotransformation; Drug development; Metabolites; Saponins; lactones; sesquiterpenoids; monoterpenoids; Essential oils; Organic compounds; carbonyls; Fragrances; Antitumor activity; Aspergillus niger DO - http://dx.doi.org/10.1016/j.procbio.2014.09.005 ER - TY - JOUR T1 - Measures to quantify the abuse of prescription opioids: a review of data sources and metrics AN - 1660389145; 21123840 AB - Purpose The abuse and nonmedical use of prescription opioids and its subsequent consequences are an important public health concern. This phenomenon has paralleled the increase in the therapeutic use of opioids for pain management. There is thus a need to measure prescription opioid abuse to understand trends over time and to compare abuse of one product to another. The purpose of this review is to provide an overview of the strengths and weaknesses of frequently used numerators and denominators in "abuse ratios" (ARs). Methods For this review, we critically evaluated the various measures to quantify drug availability and the available data sources to measure prescription opioid abuse. Results There are currently no commonly adopted metrics for measuring either the prevalence of opioid abuse, or abuse relative to drug availability. Because the settings, manifestations, and severity of abuse can vary from one person to the next, no one measure of abuse, abuse-related outcome, or drug exposure is ideal. Each measure of abuse captures a specific facet of abuse, but not the whole spectrum. Reliable estimation of population-adjusted or utilization-adjusted rates of abuse can be accomplished with a prescription opioid AR. This metric estimates the prevalence of abuse in a given population or abuse relative to how much drug is available, and, in certain cases, can be used to compare abuse among various opioid drugs. AR measurements in the literature vary in the inclusion of specific measures of abuse and availability, and there is little consensus in the field regarding which measures allow for the most appropriate approximation of the extent of abuse, and for comparisons among opioids. Crude numbers of outcomes related to abuse (e.g., emergency department visits, treatment admissions, and overdoses) cannot be properly understood without context as these may overestimate or underestimate the true scope and severity of prescription opioid abuse. They can, however, serve as numerators in properly constructed ARs. The denominator of the AR provides the necessary context by accounting for populations at risk or drug availability (e.g., prescriptions or tablets dispensed, unique recipients of dispensed drug, total patient days of therapy, or kilograms sold), and each comes with its own set of assumptions to consider. Conclusions Moving forward, it is important that there be a common understanding in the scientific community regarding how to select appropriate measures to serve as numerators and denominators in AR calculations, and how to interpret the resultant findings. There is no single best measure of abuse for use as a numerator in an AR, and each must be chosen and interpreted in the context of what it measures. For public health considerations, one must always look at both absolute numbers and adjusted numbers. When conducting multiple analyses using different measures of exposure as denominators, differences in ARs are not unexpected, but one should explore why there are differences and assess the appropriateness of each of the denominators. Copyright copyright 2014 John Wiley & Sons, Ltd. JF - Pharmacoepidemiology and Drug Safety AU - Secora, Alex M AU - Dormitzer, Catherine M AU - Staffa, Judy A AU - Dal Pan, Gerald J AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1227 EP - 1237 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 23 IS - 12 SN - 1053-8569, 1053-8569 KW - Toxicology Abstracts KW - Overdose KW - Data processing KW - Reviews KW - Tablets KW - Opioids KW - Pain KW - Drug abuse KW - Abuse KW - Public health KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660389145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Measures+to+quantify+the+abuse+of+prescription+opioids%3A+a+review+of+data+sources+and+metrics&rft.au=Secora%2C+Alex+M%3BDormitzer%2C+Catherine+M%3BStaffa%2C+Judy+A%3BDal+Pan%2C+Gerald+J&rft.aulast=Secora&rft.aufirst=Alex&rft.date=2014-12-01&rft.volume=23&rft.issue=12&rft.spage=1227&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.3711 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Overdose; Data processing; Reviews; Tablets; Pain; Opioids; Drug abuse; Abuse; Public health DO - http://dx.doi.org/10.1002/pds.3711 ER - TY - JOUR T1 - Respiratory manganese particle size, time-course and neurobehavioral outcomes in workers at a manganese alloy production plant AN - 1647011513; 21321512 AB - The progression of manganism with chronic exposure to airborne manganese (Mn) is not well understood. Here, we further investigate the findings on exposure and neurobehavioral outcomes of workers from a silico- and ferromanganese production plant and non-exposed workers from the same community in 1990 and 2004, using a variety of exposure metrics that distinguish particle size and origin within the range of respirable airborne exposures. Mn exposure matrices for large respirable particulate (Mn-LRP, dust) and small respirable particulate (Mn-SRP, fume), based on process origins, were used together with detailed work histories since 1973 (plant opening), to construct exposure metrics including burdens and cumulative burdens with various clearance half-lives. For three out of eight 1990 neurobehavioral tests analyzed with linear regression models, duration of Mn exposure was the best predictor: Luria-Nebraska Neuropsychological Battery - Motor Scale, Trail-Making B and Finger Tapping. The Luria-Nebraska Motor Scale had the strongest association (t 5.0, p <10-6). For outcomes on three other tests, the duration and Mn-SRP metrics were comparable: Trail Making Test A, Cancellation H and Stroop Color-Word Test (color/word subtest). Delayed Word Recall was best predicted by Mn-SRP (based on square root or truncated air-concentrations). The Word score on the Stroop Color-Word Test was the only outcome for which Mn-LRP was the leading predictor (t =-2.92, p =0.003), while performance on the WAIS-R Digit Span Test was not significantly predicted by any metric. For outcomes evaluated in both 1990 and 2004, a mixed-effect linear regression model was used to examine estimates of within-individual trends. Duration and Mn-SRP were associated with performance on the Luria-Nebraska Motor Scale, as well as with other outcomes that appeared to have both reversible and progressive features, including Trail Making A and B, Cancellation H and Delayed Word Recall. With the mixed-effect model, Digit Span exhibited a significant irreversible association with exposure duration (t =-2.34, p =0.021) and Mn-SRP (square root; t =-2.38, p =0.019) metrics. The strong prediction using duration of exposure is consistent with effective homeostatic regulation of tissue-level Mn in the observed exposure range of respirable Mn (<0.2mg/m3). JF - Neurotoxicology AU - Park, Robert M AU - Bouchard, Maryse F AU - Baldwin, Mary AU - Bowler, Rosemarie AU - Mergler, Donna AD - U.S. National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 276 EP - 284 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 45 SN - 0161-813X, 0161-813X KW - Health & Safety Science Abstracts; Environment Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Manganese KW - Burden KW - Fume KW - Half-life KW - Homeostasis KW - Prediction KW - Particle size KW - Historical account KW - Fumes KW - Motor task performance KW - Particulates KW - Dust KW - Finger KW - Color KW - Workers KW - Chronic exposure KW - Neurotoxicity KW - Plant communities KW - Regression analysis KW - Alloys KW - alloys KW - Occupational exposure KW - N3 11028:Neuropharmacology & toxicology KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647011513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Respiratory+manganese+particle+size%2C+time-course+and+neurobehavioral+outcomes+in+workers+at+a+manganese+alloy+production+plant&rft.au=Park%2C+Robert+M%3BBouchard%2C+Maryse+F%3BBaldwin%2C+Mary%3BBowler%2C+Rosemarie%3BMergler%2C+Donna&rft.aulast=Park&rft.aufirst=Robert&rft.date=2014-12-01&rft.volume=45&rft.issue=&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2014.03.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Particle size; Fumes; Motor task performance; Dust; Color; Finger; Workers; Chronic exposure; Regression analysis; Plant communities; alloys; Manganese; Occupational exposure; Prediction; Historical account; Neurotoxicity; Alloys; Particulates DO - http://dx.doi.org/10.1016/j.neuro.2014.03.015 ER - TY - JOUR T1 - Airborne manganese as dust vs. fume determining blood levels in workers at a manganese alloy production plant AN - 1647007534; 21321504 AB - The appropriate exposure metrics for characterizing manganese (Mn) exposure associated with neurobehavioral effects have not been established. Blood levels of Mn (B-Mn) provide a potentially important intermediate marker of Mn airborne exposures. Using data from a study of a population of silicon- and ferro-manganese alloy production workers employed between 1973 and 1991, B-Mn levels were modeled in relation to prior Mn exposure using detailed work histories and estimated respirable Mn concentrations from air-sampling records. Despite wide variation in exposure levels estimated for individual jobs, duration of employment (exposure) was itself a strong predictor of B-Mn levels and strongest when an 80-day half-life was applied to contributions over time (t =6.95, 7.44, respectively; p <10-5). Partitioning exposure concentrations based on process origin into two categories: (1) "large" respirable particulate (Mn-LRP) derived mainly from mechanically generated dust, and (2) "small" respirable particulate (Mn-SRP) primarily electric furnace condensation fume, revealed that B-Mn levels largely track the small, fume exposures. With a half-life of 65 days applied in a model with cumulative exposure terms for both Mn-LRP (t =-0.16, p =0.87) and Mn-SRP (t =6.45, p <10-5), the contribution of the large-size fraction contribution was negligible. Constructing metrics based on the square root of SRP exposure concentrations produced a better model fit (t =7.87 vs. 7.44, R 2 =0.2333 vs. 0.2157). In a model containing both duration (t =0.79, p =0.43) and (square root) fume (t =2.47, p =0.01) metrics, the duration term was a weak contributor. Furnace-derived, small respirable Mn particulate appears to be the primary contributor to B-Mn levels, with a dose-rate dependence in a population chronically exposed to Mn, with air-concentrations declining in recent years. These observations may reflect the presence of homeostatic control of Mn levels in the blood and other body tissues and be useful in assessing Mn exposures for evaluating neurotoxic effects. JF - Neurotoxicology AU - Park, Robert M AU - Baldwin, Mary AU - Bouchard, Maryse F AU - Mergler, Donna AD - U.S. National Institute for Occupational Safety and Health, Cincinnati, USA Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 267 EP - 275 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 45 SN - 0161-813X, 0161-813X KW - Health & Safety Science Abstracts; Environment Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Manganese KW - Respiratory particle size KW - Half-life KW - Blood manganese KW - Manganese alloy production KW - Historical account KW - Particulates KW - Employment KW - Dust KW - Workers KW - Furnaces KW - Air sampling KW - Alloys KW - alloys KW - Occupational exposure KW - Fumes KW - Data processing KW - Population studies KW - Blood levels KW - Blood KW - Neurotoxicity KW - Condensation KW - N3 11028:Neuropharmacology & toxicology KW - H 1000:Occupational Safety and Health KW - X 24360:Metals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647007534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Airborne+manganese+as+dust+vs.+fume+determining+blood+levels+in+workers+at+a+manganese+alloy+production+plant&rft.au=Park%2C+Robert+M%3BBaldwin%2C+Mary%3BBouchard%2C+Maryse+F%3BMergler%2C+Donna&rft.aulast=Park&rft.aufirst=Robert&rft.date=2014-12-01&rft.volume=45&rft.issue=&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2014.03.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Workers; Blood; Data processing; Fumes; Neurotoxicity; Population studies; Condensation; alloys; Manganese; Dust; Occupational exposure; Blood levels; Historical account; Furnaces; Air sampling; Alloys; Employment; Particulates DO - http://dx.doi.org/10.1016/j.neuro.2014.03.006 ER - TY - JOUR T1 - Thymol treatment of bacteria prior to matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis aids in identifying certain bacteria at the subspecies level AN - 1642623519; 20912854 AB - RATIONALE The identification of bacteria based on mass spectra produced by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) has become routine since its introduction in 1996. The major drawback is that bacterial patterns produced by MALDI are dependent on sample preparation prior to analysis. This results in poor reproducibility in identifying bacterial types and between laboratories. The need for a more broadly applicable and useful sample handling procedure is warranted. METHODS Thymol was added to the suspension solvent of bacteria prior to MALDI analysis. The suspension solvent consisted of ethanol, water and TFA. The bacterium was added to the thymol suspension solvent and heated. An aliquot of the bacterial suspension was mixed directly with the matrix solution at a 9:1 ratio, matrix/bacteria solution, respectively. The mixture was then placed on the MALDI plate and allowed to air dry before MALDI analysis. RESULTS The thymol method improved the quality of spectra and number of peaks when compared to other sample preparation procedures studied. The bacterium-identifying biomarkers assigned to four strains of E. coli were statistically 95% reproducible analyzed on three separate days. The thymol method successfully differentiated between the four E. coli strains. In addition, the thymol procedure could identify nine out of ten S. enterica serovars over a 3-day period and nine S. Typhimurium strains from the other ten serovars 90% of the time over the same period. CONCLUSIONS The thymol method can identify certain bacteria at the sub-species level and yield reproducible results over time. It improves the quality of spectra by increasing the number of peaks when compared to the other sample preparation methods assessed in this study. Published in 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Rapid Communications in Mass Spectrometry AU - Holland, Ricky D AU - Wilkes, Jon G AU - Cooper, Willie M AU - Alusta, Pierre AU - Williams, Anna AU - Pearce, Bruce AU - Beaudoin, Michael AU - Buzatu, Dan AD - Division of Systems Biology/Innovative Safety and Technologies Branch, USFDA/National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, 72079, USA. Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 2617 EP - 2626 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 28 IS - 23 SN - 0951-4198, 0951-4198 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Escherichia coli KW - Solvents KW - thymol KW - Lasers KW - Salmonella typhimurium KW - Ionization KW - biomarkers KW - Mass spectroscopy KW - Ethanol KW - V 22360:AIDS and HIV KW - A 01300:Methods KW - J 02450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642623519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Rapid+Communications+in+Mass+Spectrometry&rft.atitle=Thymol+treatment+of+bacteria+prior+to+matrix-assisted+laser+desorption%2Fionization+time-of-flight+mass+spectrometric+analysis+aids+in+identifying+certain+bacteria+at+the+subspecies+level&rft.au=Holland%2C+Ricky+D%3BWilkes%2C+Jon+G%3BCooper%2C+Willie+M%3BAlusta%2C+Pierre%3BWilliams%2C+Anna%3BPearce%2C+Bruce%3BBeaudoin%2C+Michael%3BBuzatu%2C+Dan&rft.aulast=Holland&rft.aufirst=Ricky&rft.date=2014-12-01&rft.volume=28&rft.issue=23&rft.spage=2617&rft.isbn=&rft.btitle=&rft.title=Rapid+Communications+in+Mass+Spectrometry&rft.issn=09514198&rft_id=info:doi/10.1002%2Frcm.7060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Solvents; Lasers; thymol; biomarkers; Ionization; Mass spectroscopy; Ethanol; Escherichia coli; Salmonella typhimurium DO - http://dx.doi.org/10.1002/rcm.7060 ER - TY - JOUR T1 - Abundance of Vibrio cholerae, V. vulnificus, and V. parahaemolyticus in Oysters (Crassostrea virginica) and Clams (Mercenaria mercenaria) from Long Island Sound AN - 1642618644; 21154623 AB - Vibriosis is a leading cause of seafood-associated morbidity and mortality in the United States. Typically associated with consumption of raw or undercooked oysters, vibriosis associated with clam consumption is increasingly being reported. However, little is known about the prevalence of Vibrio spp. in clams. The objective of this study was to compare the levels of Vibrio cholerae, Vibrio vulnificus, and Vibrio parahaemolyticus in oysters and clams harvested concurrently from Long Island Sound (LIS). Most probable number (MPN)-real-time PCR methods were used for enumeration of total V. cholerae, V. vulnificus, V. parahaemolyticus, and pathogenic (tdh+ and/or trh+) V. parahaemolyticus. V. cholerae was detected in 8.8% and 3.3% of oyster (n = 68) and clam (n = 30) samples, with levels up to 1.48 and 0.48 log MPN/g in oysters and clams, respectively. V. vulnificus was detected in 97% and 90% of oyster and clam samples, with median levels of 0.97 and -0.08 log MPN/g, respectively. V. parahaemolyticus was detected in all samples, with median levels of 1.88 and 1.07 log MPN/g for oysters and clams, respectively. The differences between V. vulnificus and total and pathogenic V. parahaemolyticus levels in the two shellfish species were statistically significant (P < 0.001). These data indicate that V. vulnificus and total and pathogenic V. parahaemolyticus are more prevalent and are present at higher levels in oysters than in hard clams. Additionally, the data suggest differences in vibrio populations between shellfish harvested from different growing area waters within LIS. These results can be used to evaluate and refine illness mitigation strategies employed by risk managers and shellfish control authorities. JF - Applied and Environmental Microbiology AU - Jones, Jessica L AU - Luedeke, Catharina HM AU - Bowers, John C AU - DeRosia-Banick, Kristin AU - Carey, David H AU - Hastback, William AD - FDA, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, Dauphin Island, Alabama, USA, Jessica.Jones@fda.hhs.gov. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 7667 EP - 7672 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 80 IS - 24 SN - 0099-2240, 0099-2240 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Nucleotide sequence KW - Abundance KW - Statistical analysis KW - Morbidity KW - Islands KW - Vibrio vulnificus KW - Vibrio parahaemolyticus KW - Sound KW - Polymerase chain reaction KW - Mercenaria mercenaria KW - Marine KW - Mortality KW - Data processing KW - ANW, USA, Long Island Sound KW - Pathogenic bacteria KW - Shellfish fisheries KW - Vibriosis KW - Vibrio cholerae KW - USA KW - Most probable number KW - Microbiology KW - DNA KW - Marine molluscs KW - Crassostrea virginica KW - Mortality causes KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642618644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Abundance+of+Vibrio+cholerae%2C+V.+vulnificus%2C+and+V.+parahaemolyticus+in+Oysters+%28Crassostrea+virginica%29+and+Clams+%28Mercenaria+mercenaria%29+from+Long+Island+Sound&rft.au=Jones%2C+Jessica+L%3BLuedeke%2C+Catharina+HM%3BBowers%2C+John+C%3BDeRosia-Banick%2C+Kristin%3BCarey%2C+David+H%3BHastback%2C+William&rft.aulast=Jones&rft.aufirst=Jessica&rft.date=2014-12-01&rft.volume=80&rft.issue=24&rft.spage=7667&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.02820-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 36 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Vibriosis; Shellfish fisheries; Pathogenic bacteria; Nucleotide sequence; Microbiology; DNA; Polymerase chain reaction; Marine molluscs; Mortality causes; Mortality; Most probable number; Data processing; Islands; Abundance; Statistical analysis; Sound; Morbidity; Vibrio cholerae; Vibrio vulnificus; Vibrio parahaemolyticus; Crassostrea virginica; Mercenaria mercenaria; USA; ANW, USA, Long Island Sound; Marine DO - http://dx.doi.org/10.1128/AEM.02820-14 ER - TY - JOUR T1 - Interleukin-4 receptor alpha overexpression in human bladder cancer correlates with the pathological grade and stage of the disease. AN - 1642609399; 25208941 AB - Previously, we have demonstrated that interleukin-4 receptor α (IL-4Rα) is overexpressed on a variety of human cancers and can serve as target for IL-4 immunotoxin comprised of IL-4 and a mutated Pseudomonas exotoxin. However, its expression and association with grade and clinical stage of bladder cancer has not been studied. IL-4Rα expression was examined in human bladder cancer cell lines, mouse xenografts, and biopsy specimens at mRNA and protein levels by real-time RT-PCR and IHC/ISH techniques. We also examined the effect of IL-4 on proliferation and invasion of bladder carcinoma cell lines. For tissue microarray (TMA) results, we analyzed the precision data using exact binomial proportion with exact two-sided P-values. We used Cochran-Armitage Statistics with exact two-sided P-values to examine the trend analysis of IL-4Rα over grade or stage of the bladder cancer specimens. The influence of age and gender covariates was also analyzed using multiple logistic regression models. IL-4Rα is overexpressed in five bladder cancer cell lines, while normal bladder and human umbilical vein cell lines (HUVEC) expressed at low levels. Two other chains of IL-4 receptor complex, IL-2RγC and IL-13Rα1, were absent or weakly expressed. IL-4 modestly inhibited the cell proliferation, but enhanced cell invasion of bladder cancer cell lines in a concentration-dependent manner. Bladder cancer xenografts in immunodeficient mice also maintained IL-4Rα overexpression in vivo. Analysis of tumor biopsy specimens in TMAs revealed significantly higher IL-4Rα immunostaining (≥ 2+) in Grade 2 (85%) and Grade 3 (97%) compared to Grade 1 tumors (0%) (P ≤ 0.0001). Similarly, 9% stage I tumors were positive for IL-4Rα (≥ 2+) compared to 84% stage II (P ≤ 0.0001) and 100% stages III-IV tumors (P ≤ 0.0001). IL-13Rα1 was also expressed in tumor tissues but at low levels and it did not show any correlation with the grade and stage of disease. However, the IL-2RγC was not expressed. Ten normal bladder specimens demonstrated ≤ 1+ staining for IL-4Rα and IL-13Rα1 and no staining for IL-2RγC. These results demonstrate that IL-4Rα is overexpressed in human bladder cancer, which correlates with advanced grade and stage of the disease. Thus, IL-4Rα may be a bladder tumor-associated protein and a prognostic biomarker. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. Cancer Medicine published by John Wiley & Sons Ltd. JF - Cancer medicine AU - Joshi, Bharat H AU - Leland, Pamela AU - Lababidi, Samir AU - Varrichio, Frederick AU - Puri, Raj K AD - Tumor Vaccines and Biotechnology Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapy, Center for Biologics Evaluation and Research, NIH Building 29B, Room 2E1229 Lincoln Drive, Bethesda, 20892, Maryland. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1615 EP - 1628 VL - 3 IS - 6 KW - IL4R protein, human KW - 0 KW - Interleukin-4 Receptor alpha Subunit KW - Index Medicus KW - IL-4Rα KW - grade and clinical stage KW - tumor aggressiveness KW - bladder cancer-associated protein KW - Biomarker KW - Real-Time Polymerase Chain Reaction KW - Heterografts KW - Animals KW - Neoplasm Staging KW - Humans KW - Aged KW - Cell Line, Tumor KW - Human Umbilical Vein Endothelial Cells KW - Mice KW - Mice, Nude KW - Tissue Array Analysis KW - Adult KW - Neoplasm Grading KW - Middle Aged KW - Immunohistochemistry KW - Female KW - Urinary Bladder Neoplasms -- pathology KW - Urinary Bladder Neoplasms -- genetics KW - Interleukin-4 Receptor alpha Subunit -- genetics KW - Urinary Bladder Neoplasms -- metabolism KW - Interleukin-4 Receptor alpha Subunit -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642609399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+medicine&rft.atitle=Interleukin-4+receptor+alpha+overexpression+in+human+bladder+cancer+correlates+with+the+pathological+grade+and+stage+of+the+disease.&rft.au=Joshi%2C+Bharat+H%3BLeland%2C+Pamela%3BLababidi%2C+Samir%3BVarrichio%2C+Frederick%3BPuri%2C+Raj+K&rft.aulast=Joshi&rft.aufirst=Bharat&rft.date=2014-12-01&rft.volume=3&rft.issue=6&rft.spage=1615&rft.isbn=&rft.btitle=&rft.title=Cancer+medicine&rft.issn=2045-7634&rft_id=info:doi/10.1002%2Fcam4.330 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-09-23 N1 - Date created - 2015-01-05 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Int J Hematol. 1999 Jan;69(1):13-20 [10641437] J Neurooncol. 2003 Aug-Sep;64(1-2):125-37 [12952293] Cancer Res. 2000 Jun 1;60(11):2981-7 [10850446] Clin Cancer Res. 2000 Jun;6(6):2157-65 [10873064] J Immunol. 2001 Dec 1;167(11):6497-502 [11714817] Cancer Res. 2001 Nov 15;61(22):8058-61 [11719427] J Neurooncol. 2003 Oct;65(1):15-25 [14649882] Cancer Cell. 2004 Aug;6(2):111-6 [15324694] Cell. 1990 Aug 10;62(3):457-67 [2116236] Science. 1991 Nov 1;254(5032):713-6 [1948050] Cancer Res. 1992 Jan 15;52(2):275-9 [1728401] J Clin Invest. 1993 Jan;91(1):88-93 [8423237] Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2774-8 [8464888] Int J Cancer. 1995 Nov 3;63(3):366-71 [7591233] Cell Immunol. 1996 Jul 10;171(1):80-6 [8660841] Clin Exp Immunol. 1996 Aug;105(2):344-52 [8706344] Mol Med. 1997 May;3(5):327-38 [9205948] Blood. 1998 May 15;91(10):3884-91 [9573026] J Immunol. 1998 Jun 15;160(12):5869-73 [9637498] Int J Cancer. 1998 Jul 3;77(1):7-12 [9639386] J Immunother. 1998 Nov;21(6):440-6 [9807739] J Exp Med. 1999 Mar 15;189(6):919-30 [10075975] Nat Med. 1999 Jul;5(7):817-22 [10395328] Br J Cancer. 2005 Mar 14;92(5):921-8 [15714203] Cancer. 2005 May 15;103(10):2132-42 [15830341] J Immunother. 2005 Jul-Aug;28(4):376-81 [16000956] Cancer Res. 2005 Sep 15;65(18):8388-96 [16166317] Cancer Res. 2007 Oct 15;67(20):9903-12 [17942922] Cell Stem Cell. 2007 Oct 11;1(4):389-402 [18371377] Cancer Res. 2008 Nov 1;68(21):8687-94 [18974110] Cancer Cell. 2009 Aug 4;16(2):91-102 [19647220] Cell Mol Immunol. 2009 Dec;6(6):415-22 [20003817] Carcinogenesis. 2010 Jun;31(6):1010-7 [20176658] J Leukoc Biol. 2010 Jun;87(6):1011-8 [20335310] Nucleic Acids Res. 2011 Jan;39(Database issue):D945-50 [20952405] J Exp Med. 2011 Mar 14;208(3):469-78 [21339327] Clin Cancer Res. 2011 May 1;17(9):2757-66 [21536546] Cancer. 2011 Nov 15;117(22):5234-44 [21523763] Clin Cancer Res. 2012 Mar 15;18(6):1568-77 [22261806] Genet Mol Res. 2013;12(2):1479-89 [23765955] J Immunol. 2014 Jan 1;192(1):523-32 [24277698] CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29 [24399786] Nature. 2014 Mar 20;507(7492):315-22 [24476821] Clin Cancer Res. 2014 Aug 15;20(16):4390-9 [24938524] Springer Semin Immunopathol. 1999;21(3):339-59 [10666777] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/cam4.330 ER - TY - JOUR T1 - An intake prior for the Bayesian analysis of plutonium and uranium exposures in an epidemiology study. AN - 1639496978; 24191121 AB - In Bayesian inference, the initial knowledge regarding the value of a parameter, before additional data are considered, is represented as a prior probability distribution. This paper describes the derivation of a prior distribution of intake that was used for the Bayesian analysis of plutonium and uranium worker doses in a recent epidemiology study. The chosen distribution is log-normal with a geometric standard deviation of 6 and a median value that is derived for each worker based on the duration of the work history and the number of reported acute intakes. The median value is a function of the work history and a constant related to activity in air concentration, M, which is derived separately for uranium and plutonium. The value of M is based primarily on measurements of plutonium and uranium in air derived from historical personal air sampler (PAS) data. However, there is significant uncertainty on the value of M that results from paucity of PAS data and from extrapolating these measurements to actual intakes. This paper compares posterior and prior distributions of intake and investigates the sensitivity of the Bayesian analyses to the assumed value of M. It is found that varying M by a factor of 10 results in a much smaller factor of 2 variation in mean intake and lung dose for both plutonium and uranium. It is concluded that if a log-normal distribution is considered to adequately represent worker intakes, then the Bayesian posterior distribution of dose is relatively insensitive to the value assumed of M. © The Author 2013. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. JF - Radiation protection dosimetry AU - Puncher, M AU - Birchall, A AU - Bull, R K AD - Department of Toxicology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot OX11 0RQ, UK matthew.puncher@phe.gov.uk. ; Department of Toxicology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot OX11 0RQ, UK. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 306 EP - 315 VL - 162 IS - 3 KW - Uranium KW - 4OC371KSTK KW - Plutonium KW - 53023GN24M KW - Index Medicus KW - Radiation Dosage KW - Computer Simulation KW - Epidemiologic Studies KW - Humans KW - Cohort Studies KW - Models, Statistical KW - Urinalysis KW - Models, Biological KW - Bayes Theorem KW - Uranium -- analysis KW - Plutonium -- analysis KW - Occupational Exposure -- analysis KW - Lung -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639496978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=An+intake+prior+for+the+Bayesian+analysis+of+plutonium+and+uranium+exposures+in+an+epidemiology+study.&rft.au=Puncher%2C+M%3BBirchall%2C+A%3BBull%2C+R+K&rft.aulast=Puncher&rft.aufirst=M&rft.date=2014-12-01&rft.volume=162&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=1742-3406&rft_id=info:doi/10.1093%2Frpd%2Fnct268 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-03 N1 - Date created - 2014-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/rpd/nct268 ER - TY - JOUR T1 - Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland AN - 1635026371; 21029934 AB - Purpose : Concerns regarding a possible link between bisphenol A (BPA) and breast cancer have been mounting, but studies in human populations are lacking. We evaluated the association between the major urinary BPA metabolite [BPA-glucuronide (BPA-G)] and postmenopausal breast cancer risk in a large population-based case-control study conducted in two cities in Poland (2000-2003); we further explored the association of BPA-G levels with known postmenopausal breast cancer risk factors in our control population. Methods: We analyzed creatinine-adjusted urinary BPA-G levels among 575 postmenopausal cases matched on age and study site to 575 controls without breast cancer using a recently developed assay. Odds ratios and 95 % confidence intervals were used to estimate the association between urinary BPA-G level and breast cancer using conditional logistic regression. Among controls, geometric mean BPA-G levels were compared across categories of breast cancer risk factors using linear regression models. Results: There was no indication that increased BPA-G was associated with postmenopausal breast cancer (p-trend = 0.59). Among controls, mean BPA-G was higher among women reporting extended use of menopausal hormones, a prior screening mammogram, and residence in Warsaw. Other comparisons across strata of postmenopausal breast cancer risk factors were not related to differences in BPA-G. Conclusions: Urinary BPA-G, measured at the time of diagnosis, is not linked to postmenopausal breast cancer. JF - Cancer Causes & Control AU - Trabert, Britton AU - Falk, Roni T AU - Figueroa, Jonine D AU - Graubard, Barry I AU - Garcia-Closas, Montserrat AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Fox, Stephen D AU - Brinton, Louise A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 7E-228, Bethesda, MD, 20892-9774, USA, britton.trabert@nih.gov Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1587 EP - 1593 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 25 IS - 12 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Bisphenol A KW - Health risks KW - Cities KW - Age KW - Post-menopause KW - Urine KW - Poland KW - Human populations KW - Breast cancer KW - Metabolites KW - Hormones KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635026371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Urinary+bisphenol+A-glucuronide+and+postmenopausal+breast+cancer+in+Poland&rft.au=Trabert%2C+Britton%3BFalk%2C+Roni+T%3BFigueroa%2C+Jonine+D%3BGraubard%2C+Barry+I%3BGarcia-Closas%2C+Montserrat%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BFox%2C+Stephen+D%3BBrinton%2C+Louise+A&rft.aulast=Trabert&rft.aufirst=Britton&rft.date=2014-12-01&rft.volume=25&rft.issue=12&rft.spage=1587&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-014-0461-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Number of references - 27 N1 - Last updated - 2015-02-12 N1 - SubjectsTermNotLitGenreText - Bisphenol A; Cities; Health risks; Age; Urine; Post-menopause; Human populations; Breast cancer; Metabolites; Hormones; Poland DO - http://dx.doi.org/10.1007/s10552-014-0461-8 ER - TY - JOUR T1 - The effectiveness of insurer-supported safety and health engineering controls in reducing workers' compensation claims and costs AN - 1635017448; 21008497 AB - Background This study evaluated the effectiveness of a program in which a workers' compensation (WC) insurer provided matching funds to insured employers to implement safety/health engineering controls. Methods Pre- and post-intervention WC metrics were compiled for the employees designated as affected by the interventions within 468 employers for interventions occurring from 2003 to 2009. Poisson, two-part, and linear regression models with repeated measures were used to evaluate differences in pre- and post-data, controlling for time trends independent of the interventions. Results For affected employees, total WC claim frequency rates (both medical-only and lost-time claims) decreased 66%, lost-time WC claim frequency rates decreased 78%, WC paid cost per employee decreased 81%, and WC geometric mean paid claim cost decreased 30% post-intervention. Reductions varied by employer size, specific industry, and intervention type. Conclusions The insurer-supported safety/health engineering control program was effective in reducing WC claims and costs for affected employees. Am. J. Ind. Med. 57:1398-1412, 2014. copyright 2014 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Wurzelbacher, Steven J AU - Bertke, Stephen J AU - Lampl, Michael P AU - Bushnell, PTimothy AU - Meyers, Alysha R AU - Robins, David C AU - Al-Tarawneh, Ibraheem S AD - National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies. Y1 - 2014/12// PY - 2014 DA - Dec 2014 SP - 1398 EP - 1412 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 12 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Workers' compensation KW - Funds KW - Safety engineering KW - Safety KW - Intervention KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635017448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=The+effectiveness+of+insurer-supported+safety+and+health+engineering+controls+in+reducing+workers%27+compensation+claims+and+costs&rft.au=Wurzelbacher%2C+Steven+J%3BBertke%2C+Stephen+J%3BLampl%2C+Michael+P%3BBushnell%2C+PTimothy%3BMeyers%2C+Alysha+R%3BRobins%2C+David+C%3BAl-Tarawneh%2C+Ibraheem+S&rft.aulast=Wurzelbacher&rft.aufirst=Steven&rft.date=2014-12-01&rft.volume=57&rft.issue=12&rft.spage=1398&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22372 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2015-01-07 N1 - SubjectsTermNotLitGenreText - Workers' compensation; Funds; Safety engineering; Safety; Intervention DO - http://dx.doi.org/10.1002/ajim.22372 ER - TY - JOUR T1 - Biomarkers of exposure among U.S. cigar smokers: an analysis of 1999-2012 National Health and Nutrition Examination Survey (NHANES) data. AN - 1634271594; 25380733 AB - Cigar consumption is increasing in the United States, but little information is available about exposure to toxic constituents from cigar smoking. We conducted a cross-sectional analysis of biomarkers of tobacco exposure among 25,522 participants from the National Health and Nutrition Examination Survey (NHANES, 1999-2012). The biomarkers analyzed were serum cotinine, urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), blood lead, blood cadmium, and urinary arsenic. We calculated geometric mean concentrations for each biomarker by tobacco use category and geometric mean ratios controlling for demographic factors. Cigar smokers had higher cotinine, NNAL, and lead concentrations than nontobacco users. The geometric mean concentration [95% confidence interval (CI)] of cotinine for primary cigar smokers (i.e., current cigar/never cigarette smokers) was 6.2 (4.2-9.2) ng/mL versus 0.045 (0.043-0.048) ng/mL for nontobacco users, and the NNAL concentration was 19.1 (10.6-34.3) pg/mg creatinine for primary cigar smokers versus 1.01 (0.95-1.07) pg/mg creatinine for nontobacco users. Secondary cigar smokers (i.e., current cigar/former cigarette smokers) and dual cigar/cigarette smokers had higher cadmium concentrations than nontobacco users. Cigar smoking was associated with significantly higher concentrations of cotinine, NNAL, cadmium, and lead, after adjusting for demographic factors. Secondary cigar smokers had significantly higher cotinine and NNAL concentrations than primary cigar smokers. The NNAL concentrations in daily cigar smokers were comparable with those in daily cigarette smokers. Cigar smokers have higher concentrations of several toxic and carcinogenic substances than nontobacco users. Our results are consistent with epidemiologic evidence demonstrating cigar smoking as a cause of disease and premature death. ©2014 American Association for Cancer Research. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Chen, Jiping AU - Kettermann, Anna AU - Rostron, Brian L AU - Day, Hannah R AD - Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland. jiping.chen@fda.hhs.gov. ; Office of Science, Center for Tobacco Products, U.S. Food and Drug Administration, Silver Spring, Maryland. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 2906 EP - 2915 VL - 23 IS - 12 KW - Biomarkers KW - 0 KW - Carcinogens KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - United States KW - Cross-Sectional Studies KW - History, 21st Century KW - History, 20th Century KW - Humans KW - Nutrition Surveys KW - Middle Aged KW - Male KW - Female KW - Biomarkers -- analysis KW - Nicotine -- analysis KW - Smoking -- adverse effects KW - Carcinogens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1634271594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Biomarkers+of+exposure+among+U.S.+cigar+smokers%3A+an+analysis+of+1999-2012+National+Health+and+Nutrition+Examination+Survey+%28NHANES%29+data.&rft.au=Chen%2C+Jiping%3BKettermann%2C+Anna%3BRostron%2C+Brian+L%3BDay%2C+Hannah+R&rft.aulast=Chen&rft.aufirst=Jiping&rft.date=2014-12-01&rft.volume=23&rft.issue=12&rft.spage=2906&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=1538-7755&rft_id=info:doi/10.1158%2F1055-9965.EPI-14-0849 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-11 N1 - Date created - 2014-12-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1055-9965.EPI-14-0849 ER - TY - JOUR T1 - Identification of potential biomarkers of P-glycoprotein substrate neurotoxicity in transgenic mice expressing the mutated canine ABCB1 gene. AN - 1628238421; 25419811 AB - To identify biomarkers of P-glycoprotein (P-gp) substrate neurotoxicity in transgenic mice expressing the mutant canine ABCB1 gene (ABCB1-1Δ). 8 ABCB1 knock-in and knock-out transgenic mice expressing the ABCB1-1Δ gene and 8 control mice expressing the wild-type canine ABCB1 gene (ABCB1-WT). Groups including 2 ABCB1-1Δ mutant mice and 2 ABCB1-WT mice were administered the P-gp substrates ivermectin (10 mg/kg, SC), doramectin (10 mg/kg, SC), moxidectin (10 mg/kg, PO), or digoxin (1.53 mg/kg, SC). A toxicogenomic approach based on DNA microarrays was used to examine whole-genome expression changes in mice administered P-gp substrates. Compared with control ABCB1-WT mice, ABCB1-1Δ mutant mice developed neurotoxic signs including ataxia, lethargy, and tremors similar to those reported for dogs with the ABCB1-1Δ mutation. Microarray analysis revealed that gene expression was altered in ABCB1-1Δ mutant mice, compared with findings for ABCB1-WT mice, following administration of the same P-gp substrates. Gene pathway analysis revealed that genes with a ≥ 2-fold gene expression change were associated with behavior and nervous system development and function. Moreover, 34 genes were altered in the ABCB1-1Δ mutant mice in all 4 drug treatment groups. These genes were also associated with behavior, which was identified as the top-ranked gene network. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Δ mutant mice following exposure to various P-gp substrates. Some genes appear to be potential biomarkers of P-gp substrate neurotoxicity that might be used to predict the safety of those drugs in dogs with the ABCB1-1Δ mutation. JF - American journal of veterinary research AU - Zhu, Min AU - Ming, Yi AU - Swaim, Heidi AU - Swain, Marla D AU - Myers, Michael J AU - Deaver, Christine AU - Wu, Xiaolin AU - Jones, Yolanda L AU - Yancy, Haile F AD - Office of Research, Center for Veterinary Medicine, US FDA, 8401 Muirkirk Rd, Laurel, MD 20708. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 1104 EP - 1110 VL - 75 IS - 12 KW - Biomarkers KW - 0 KW - Cardiotonic Agents KW - Insecticides KW - Organic Anion Transporters KW - P-Glycoproteins KW - Digoxin KW - 73K4184T59 KW - Index Medicus KW - Genotype KW - Animals KW - Gene Expression Regulation -- physiology KW - Dogs KW - Mice KW - Substrate Specificity KW - Neurotoxicity Syndromes -- genetics KW - Mice, Transgenic KW - Mutation KW - Insecticides -- toxicity KW - Insecticides -- metabolism KW - Cardiotonic Agents -- metabolism KW - P-Glycoproteins -- genetics KW - Organic Anion Transporters -- genetics KW - Digoxin -- toxicity KW - Cardiotonic Agents -- toxicity KW - Digoxin -- metabolism KW - Organic Anion Transporters -- metabolism KW - P-Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1628238421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+veterinary+research&rft.atitle=Identification+of+potential+biomarkers+of+P-glycoprotein+substrate+neurotoxicity+in+transgenic+mice+expressing+the+mutated+canine+ABCB1+gene.&rft.au=Zhu%2C+Min%3BMing%2C+Yi%3BSwaim%2C+Heidi%3BSwain%2C+Marla+D%3BMyers%2C+Michael+J%3BDeaver%2C+Christine%3BWu%2C+Xiaolin%3BJones%2C+Yolanda+L%3BYancy%2C+Haile+F&rft.aulast=Zhu&rft.aufirst=Min&rft.date=2014-12-01&rft.volume=75&rft.issue=12&rft.spage=1104&rft.isbn=&rft.btitle=&rft.title=American+journal+of+veterinary+research&rft.issn=1943-5681&rft_id=info:doi/10.2460%2Fajvr.75.12.1104 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-21 N1 - Date created - 2014-11-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.2460/ajvr.75.12.1104 ER - TY - JOUR T1 - Identification and genetic characterization of Clostridium botulinum serotype A strains from commercially pasteurized carrot juice AN - 1627976300; 20957734 AB - Clostridium botulinum is an important foodborne pathogen capable of forming heat resistant endospores and producing deadly botulinum neurotoxins (BoNTs). In 2006, C. botulinum was responsible for an international outbreak of botulism attributed to the consumption of commercially pasteurized carrot juice. The purpose of this study was to isolate and characterize strains of C. botulinum from the adulterated product. Carrot juice bottles retrieved from the manufacturing facility were analyzed for the presence of BoNT and BoNT-producing isolates using DIG-ELISA. Toxigenic isolates from the carrot juice were analyzed using pulsed-field gel electrophoresis (PFGE) and DNA microarray analysis to determine their genetic relatedness to the original outbreak strains CDC51348 and CDC51303. PFGE revealed that isolates CJ4-1 and CJ10-1 shared an identical pulsotype with strain CDC51303, whereas isolate CJ5-1 displayed a unique restriction banding pattern. DNA microarray analysis identified several phage related genes unique to strain CJ5-1, and Southern hybridization analysis of XhoI digested and nondigested DNA showed their chromosomal location, while a homolog to pCLI_A009 of plasmid pCLI of C. botulinum serotype Langeland F, was located on a small plasmid. The acquisition or loss of bacteriophages and other mobile genetic elements among C. botulinum strains has epidemiological and evolutionary implications. JF - Food Microbiology AU - Marshall, Kristin M AU - Nowaczyk, Louis II AU - Raphael, Brian H AU - Skinner, Guy E AU - Rukma Reddy, N AD - Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 6502 South Archer Road, Bedford Park, IL 60501, USA Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 149 EP - 155 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 44 SN - 0740-0020, 0740-0020 KW - Genetics Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clostridium botulinum DNA microarray KW - PFGE (pulsed-field gel electrophoresis) KW - Botulinum neurotoxin (BoNT) KW - Plasmids KW - Bacteriophage KW - Phages KW - Serotypes KW - Botulism KW - Food KW - Juices KW - Daucus KW - Clostridium botulinum KW - Pathogens KW - DNA microarrays KW - Hybridization analysis KW - Heat KW - Pulsed-field gel electrophoresis KW - Botulinum toxin KW - Evolution KW - G 07800:Plants and Algae KW - A 01330:Food Microbiology KW - J 02400:Human Diseases KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627976300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Identification+and+genetic+characterization+of+Clostridium+botulinum+serotype+A+strains+from+commercially+pasteurized+carrot+juice&rft.au=Marshall%2C+Kristin+M%3BNowaczyk%2C+Louis+II%3BRaphael%2C+Brian+H%3BSkinner%2C+Guy+E%3BRukma+Reddy%2C+N&rft.aulast=Marshall&rft.aufirst=Kristin&rft.date=2014-12-01&rft.volume=44&rft.issue=&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.05.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Phages; Serotypes; Botulism; Food; Juices; Pathogens; Plasmids; DNA microarrays; Hybridization analysis; Heat; Pulsed-field gel electrophoresis; Botulinum toxin; Evolution; Daucus; Clostridium botulinum DO - http://dx.doi.org/10.1016/j.fm.2014.05.009 ER - TY - JOUR T1 - Cross-sectional study of genital carcinogenic HPV infections in Paramaribo, Suriname: prevalence and determinants in an ethnically diverse population of women in a pre-vaccination era. AN - 1625347168; 24920666 AB - Cervical cancer is caused by carcinogenic human papillomavirus (HPV) infections. Prior to the introduction of HPV vaccination in Suriname, we performed a cross-sectional study to estimate the prevalence of and determinants for genital carcinogenic HPV infections. Women were recruited at a family planning (FP) clinic and a sexually transmitted infections (STI) clinic. Vaginal swabs were used for HPV genotyping by the SPF10 PCR-DEIA-LiPA25 system. Logistic regression was used to identify determinants for carcinogenic HPV infection. The prevalence of any HPV was 54.2% and of carcinogenic HPV was 27.9% among 813 women attending the FP clinic. Among the 188 women attending the STI clinic, the prevalence of any HPV (76.1%) and of carcinogenic HPV (40.4%) was significantly higher. HPV52 was the most prevalent genotype in both clinics. The prevalence of HPV16 and/or 18 was 6.4% in the FP clinic and 12.2% in the STI clinic. The following determinants were independently associated with carcinogenic HPV infection among women visiting the FP clinic: ≥2 recent partners (OR 1.53; 95% CI 1.13 to 2.06), Chlamydia trachomatis co-infection (OR 1.89; 95% CI 1.32 to 2.70), disassortative ethnic sexual mixing (OR 1.50; 95% CI 1.13 to 1.99) and ethnic group (OR 1.90; 95% CI 1.27 to 2.85 for Creole and OR 1.67; 95% CI 1.06 to 2.62 for mixed ethnicity, both compared with Hindustani). No independent determinants were found among women visiting the STI clinic. Carcinogenic HPV is highly prevalent among women in Suriname, and not equally distributed among ethnic groups. These data provide a baseline to assess possible shifts in the prevalence of HPV genotypes following vaccination. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Sexually transmitted infections AU - Geraets, Daan T AU - Grünberg, Antoon W AU - van der Helm, Jannie J AU - Schim van der Loeff, Maarten F AU - Quint, Koen D AU - Sabajo, Leslie O A AU - de Vries, Henry J C AD - DDL Diagnostic Laboratory, Rijswijk, The Netherlands. ; Department of Public Health, Ministry of Health, Paramaribo, Suriname. ; STI Outpatient Clinic, Public Health Service Amsterdam, Amsterdam, The Netherlands Department of Research, Public Health Service Amsterdam, Amsterdam, The Netherlands. ; Department of Research, Public Health Service Amsterdam, Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. ; DDL Diagnostic Laboratory, Rijswijk, The Netherlands Department of Dermatology LUMC, University of Leiden, Leiden, The Netherlands. ; Dermatological Service, Ministry of Health, Paramaribo, Suriname. ; STI Outpatient Clinic, Public Health Service Amsterdam, Amsterdam, The Netherlands Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Centre for Infectious Disease Control, National Institute of Public Health and the Environment, Bilthoven, The Netherlands. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 627 EP - 633 VL - 90 IS - 8 KW - Index Medicus KW - HPV KW - Cervical Neoplasia KW - Epidemiology (Clinical) KW - Chlamydia Infection KW - Genotyping Techniques KW - Genotype KW - Young Adult KW - Cross-Sectional Studies KW - Ethnic Groups KW - Risk Factors KW - Humans KW - Adult KW - Suriname -- epidemiology KW - Female KW - Papillomavirus Infections -- epidemiology KW - Papillomaviridae -- classification KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625347168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+transmitted+infections&rft.atitle=Cross-sectional+study+of+genital+carcinogenic+HPV+infections+in+Paramaribo%2C+Suriname%3A+prevalence+and+determinants+in+an+ethnically+diverse+population+of+women+in+a+pre-vaccination+era.&rft.au=Geraets%2C+Daan+T%3BGr%C3%BCnberg%2C+Antoon+W%3Bvan+der+Helm%2C+Jannie+J%3BSchim+van+der+Loeff%2C+Maarten+F%3BQuint%2C+Koen+D%3BSabajo%2C+Leslie+O+A%3Bde+Vries%2C+Henry+J+C&rft.aulast=Geraets&rft.aufirst=Daan&rft.date=2014-12-01&rft.volume=90&rft.issue=8&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Sexually+transmitted+infections&rft.issn=1472-3263&rft_id=info:doi/10.1136%2Fsextrans-2013-051384 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-09 N1 - Date created - 2014-11-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/sextrans-2013-051384 ER - TY - JOUR T1 - Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activation. AN - 1618154513; 25134437 AB - Cigarette smoke contains reactive oxygen (ROS) that can cause oxidative stress. It increases the number of apoptotic and necrotic lung cells and further induces the development of chronic airway disease. In this study, we investigated the effects of cigarette smoke extract (CSE) on apoptosis in human bronchial epithelial cells (BEAS-2B). CSE exposure induced ROS generation and p38 mitogen-activated protein kinase (MAPK) activation that are associated with the activation of apoptosis-regulating signal kinase 1 (ASK-1). N-acetylcysteine (a general antioxidant) attenuated the CSE-induced ASK-1 and p38 MAPK activation and cell apoptosis, suggesting a triggering role of ROS in ASK-1/p38 MAPK activation during apoptotic progression. In contrast, the inhibition and knockdown of p38 attenuated the expression of anti-oxidant master NF-E2-related factor 2 (Nrf-2) and CSE-induced apoptosis, suggesting that p38 MAPK modulates Nrf-2 expression and presumably prevents cell apoptosis. Taken together, the data presented in this manuscript demonstrate that the ROS-dependent ASK-1/p38 signaling cascade regulates CSE-induced BEAS-2B cell apoptosis. In addition, anti-oxidative Nrf-2 is also up-regulated by the ROS/p38 signaling cascade in this progression. JF - Toxicology mechanisms and methods AU - Lin, Xi-Xi AU - Yang, Xin-Fu AU - Jiang, Jun-Xia AU - Zhang, Shui-Juan AU - Guan, Yan AU - Liu, Ya-Nan AU - Sun, Yan-Hong AU - Xie, Qiang-Min AD - Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration of China, Medical College of Zhejiang University , Hangzhou , China and. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 575 EP - 583 VL - 24 IS - 8 KW - Antioxidants KW - 0 KW - Complex Mixtures KW - NF-E2-Related Factor 2 KW - NFE2L2 protein, human KW - Reactive Oxygen Species KW - Smoke KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase Kinase 5 KW - EC 2.7.11.25 KW - MAP3K5 protein, human KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Nrf-2 KW - Apoptosis KW - cigarette smoke extract KW - bronchial epithelial cell KW - p38 MAPK KW - oxidative stress KW - Reactive Oxygen Species -- metabolism KW - Reactive Oxygen Species -- agonists KW - MAP Kinase Signaling System -- drug effects KW - Antioxidant Response Elements -- drug effects KW - Gene Silencing KW - Humans KW - p38 Mitogen-Activated Protein Kinases -- genetics KW - MAP Kinase Kinase Kinase 5 -- metabolism KW - Acetylcysteine -- pharmacology KW - MAP Kinase Kinase Kinase 5 -- antagonists & inhibitors KW - Complex Mixtures -- toxicity KW - Tobacco Products KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Antioxidants -- pharmacology KW - p38 Mitogen-Activated Protein Kinases -- chemistry KW - Enzyme Activation -- drug effects KW - Complex Mixtures -- antagonists & inhibitors KW - MAP Kinase Kinase Kinase 5 -- chemistry KW - Cell Line KW - NF-E2-Related Factor 2 -- genetics KW - NF-E2-Related Factor 2 -- antagonists & inhibitors KW - Respiratory Mucosa -- drug effects KW - Smoking -- adverse effects KW - Bronchi -- enzymology KW - Bronchi -- drug effects KW - NF-E2-Related Factor 2 -- metabolism KW - Respiratory Mucosa -- metabolism KW - Respiratory Mucosa -- enzymology KW - Up-Regulation -- drug effects KW - Apoptosis -- drug effects KW - Gene Expression Regulation -- drug effects KW - NF-E2-Related Factor 2 -- agonists KW - Bronchi -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1618154513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+mechanisms+and+methods&rft.atitle=Cigarette+smoke+extract-induced+BEAS-2B+cell+apoptosis+and+anti-oxidative+Nrf-2+up-regulation+are+mediated+by+ROS-stimulated+p38+activation.&rft.au=Lin%2C+Xi-Xi%3BYang%2C+Xin-Fu%3BJiang%2C+Jun-Xia%3BZhang%2C+Shui-Juan%3BGuan%2C+Yan%3BLiu%2C+Ya-Nan%3BSun%2C+Yan-Hong%3BXie%2C+Qiang-Min&rft.aulast=Lin&rft.aufirst=Xi-Xi&rft.date=2014-12-01&rft.volume=24&rft.issue=8&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Toxicology+mechanisms+and+methods&rft.issn=1537-6524&rft_id=info:doi/10.3109%2F15376516.2014.956909 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-29 N1 - Date created - 2014-10-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/15376516.2014.956909 ER - TY - JOUR T1 - Cerium oxide nanoparticles attenuate monocrotaline induced right ventricular hypertrophy following pulmonary arterial hypertension. AN - 1566407387; 25224369 AB - Cerium oxide (CeO2) nanoparticles have been posited to exhibit potent anti-oxidant activity which may allow for the use of these materials in biomedical applications. Herein, we investigate whether CeO2 nanoparticle administration can diminish right ventricular (RV) hypertrophy following four weeks of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Male Sprague Dawley rats were randomly divided into three groups: control, MCT only (60 mg/kg), or MCT + CeO2 nanoparticle treatment (60 mg/kg; 0.1 mg/kg). Compared to the control group, the RV weight to body weight ratio was 45% and 22% higher in the MCT and MCT + CeO2 groups, respectively (p < 0.05). Doppler echocardiography demonstrated that CeO2 nanoparticle treatment attenuated monocrotaline-induced changes in pulmonary flow and RV wall thickness. Paralleling these changes in cardiac function, CeO2 nanoparticle treatment also diminished MCT-induced increases in right ventricular (RV) cardiomyocyte cross sectional area, β-myosin heavy chain, fibronectin expression, protein nitrosylation, protein carbonylation and cardiac superoxide levels. These changes with treatment were accompanied by a decrease in the ratio of Bax/Bcl2, diminished caspase-3 activation and reduction in serum inflammatory markers. Taken together, these data suggest that CeO2 nanoparticle administration may attenuate the hypertrophic response of the heart following PAH. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Biomaterials AU - Kolli, Madhukar B AU - Manne, Nandini D P K AU - Para, Radhakrishna AU - Nalabotu, Siva K AU - Nandyala, Geeta AU - Shokuhfar, Tolou AU - He, Kun AU - Hamlekhan, Azhang AU - Ma, Jane Y AU - Wehner, Paulette S AU - Dornon, Lucy AU - Arvapalli, Ravikumar AU - Rice, Kevin M AU - Blough, Eric R AD - Department of Pharmacology, Physiology and Toxicology, Marshall University, Joan C. Edwards School of Medicine, Huntington, WV, United States; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, United States. ; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, United States. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, United States. ; Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, United States; School of Materials Science and Engineering, Shandong University, Ji'nan, China. ; Health Effects Laboratory Division, NIOSH, Morgantown, WV, United States. ; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States. ; Department of Pharmacology, Physiology and Toxicology, Marshall University, Joan C. Edwards School of Medicine, Huntington, WV, United States; Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, United States; Department of Cardiology, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, United States; Department of Pharmaceutical Sciences and Research, Marshall University, Huntington, WV, United States. Electronic address: blough@marshall.edu. Y1 - 2014/12// PY - 2014 DA - December 2014 SP - 9951 EP - 9962 VL - 35 IS - 37 KW - Antioxidants KW - 0 KW - Cerium KW - 30K4522N6T KW - ceric oxide KW - 619G5K328Y KW - Monocrotaline KW - 73077K8HYV KW - Index Medicus KW - Pulmonary arterial hypertension KW - Right ventricular hypertrophy KW - Cerium oxide nanoparticles KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Heart Ventricles -- drug effects KW - Male KW - Heart Ventricles -- pathology KW - Hypertrophy, Right Ventricular -- drug therapy KW - Hypertension, Pulmonary -- chemically induced KW - Hypertrophy, Right Ventricular -- etiology KW - Nanoparticles -- therapeutic use KW - Cerium -- therapeutic use KW - Antioxidants -- therapeutic use KW - Nanoparticles -- ultrastructure KW - Hypertrophy, Right Ventricular -- pathology KW - Hypertension, Pulmonary -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566407387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomaterials&rft.atitle=Cerium+oxide+nanoparticles+attenuate+monocrotaline+induced+right+ventricular+hypertrophy+following+pulmonary+arterial+hypertension.&rft.au=Kolli%2C+Madhukar+B%3BManne%2C+Nandini+D+P+K%3BPara%2C+Radhakrishna%3BNalabotu%2C+Siva+K%3BNandyala%2C+Geeta%3BShokuhfar%2C+Tolou%3BHe%2C+Kun%3BHamlekhan%2C+Azhang%3BMa%2C+Jane+Y%3BWehner%2C+Paulette+S%3BDornon%2C+Lucy%3BArvapalli%2C+Ravikumar%3BRice%2C+Kevin+M%3BBlough%2C+Eric+R&rft.aulast=Kolli&rft.aufirst=Madhukar&rft.date=2014-12-01&rft.volume=35&rft.issue=37&rft.spage=9951&rft.isbn=&rft.btitle=&rft.title=Biomaterials&rft.issn=1878-5905&rft_id=info:doi/10.1016%2Fj.biomaterials.2014.08.037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-03 N1 - Date created - 2014-09-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Circ Res. 2002 Jun 14;90(11):1150-2 [12065316] Anticancer Res. 2009 Oct;29(10):3977-82 [19846939] Circ Res. 2003 Aug 8;93(3):230-7 [12842921] Curr Opin Cardiol. 2004 Nov;19(6):575-81 [15502501] Stain Technol. 1987 Jan;62(1):23-6 [2438817] Microvasc Res. 1989 Jul;38(1):57-80 [2503687] Adv Exp Med Biol. 1991;283:477-87 [1906225] Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6 [8170963] J Cell Biol. 1997 Dec 1;139(5):1281-92 [9382873] Genes Dev. 1999 Aug 1;13(15):1899-911 [10444588] Technol Cancer Res Treat. 2005 Dec;4(6):651-9 [16292885] Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H247-56 [19395549] J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S10-9 [19555853] Ann Clin Lab Sci. 2009 Fall;39(4):378-85 [19880766] Small. 2009 Dec;5(24):2848-56 [19802857] Clin Exp Pharmacol Physiol. 2010 Feb;37(2):150-5 [19566840] Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1038-47 [20061549] Chem Commun (Camb). 2010 Apr 28;46(16):2736-8 [20369166] Int J Cardiovasc Imaging. 2010 Jun;26(5):509-18 [20140524] Eur Respir J. 2010 Jun;35(6):1286-93 [19897557] Am J Physiol Regul Integr Comp Physiol. 2010 Dec;299(6):R1666-75 [20926758] J Pharmacol Exp Ther. 2011 Jan;336(1):56-63 [20947636] Int J Nanomedicine. 2011;6:143-9 [21289991] J Pharmacol Exp Ther. 2011 Jul;338(1):53-61 [21464334] Free Radic Biol Med. 2011 Sep 15;51(6):1155-63 [21704154] Chest. 2012 Jan;141(1):210-21 [22215829] Environ Toxicol. 2013 Feb;28(2):107-18 [21618676] Nanomedicine (Lond). 2013 Sep;8(9):1483-508 [23987111] Biomaterials. 2014 Jan;35(1):249-58 [24140045] Free Radic Biol Med. 2013 Dec;65:1417-26 [24140865] Free Radic Biol Med. 2013 Aug;61:473-501 [23583330] J Pharmacol Exp Ther. 2001 Aug;298(2):469-76 [11454907] Am J Respir Crit Care Med. 2006 May 1;173(9):1023-30 [16456139] J Physiol. 2006 Jul 1;574(Pt 1):95-112 [16690706] Antioxid Redox Signal. 2006 Sep-Oct;8(9-10):1775-89 [16987031] Circulation. 2006 Sep 26;114(13):1417-31 [17000921] Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2424-30 [16731643] Cardiovasc Res. 2007 Feb 1;73(3):549-59 [17207782] Circ Res. 2007 Mar 2;100(4):474-88 [17332438] Biomaterials. 2008 Jun;29(18):2705-9 [18395249] Nat Nanotechnol. 2006 Nov;1(2):142-50 [18654167] Herz. 2002 Nov;27(7):662-8 [12439637] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.biomaterials.2014.08.037 ER - TY - CPAPER T1 - In-Process Particle Size Analysis for Commercial Pharmaceutical Manufacturing T2 - 2014 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2014) AN - 1627964590; 6311148 JF - 2014 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2014) AU - Sun, Zhigang Y1 - 2014/11/16/ PY - 2014 DA - 2014 Nov 16 KW - Particle size KW - Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627964590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2014%29&rft.atitle=In-Process+Particle+Size+Analysis+for+Commercial+Pharmaceutical+Manufacturing&rft.au=Sun%2C+Zhigang&rft.aulast=Sun&rft.aufirst=Zhigang&rft.date=2014-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2014%29&rft.issn=&rft_id=info:doi/ L2 - https://aiche.confex.com/aiche/2014/webprogram/meeting2014-11-16.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-31 N1 - Last updated - 2014-11-26 ER - TY - CPAPER T1 - Applying PAT for Pharmaceutical Powder Blending Process: Challenges and Opportunities T2 - 2014 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2014) AN - 1627963828; 6311150 JF - 2014 Annual Meeting of the American Institute for Chemical Engineering (AIChE 2014) AU - Wu, Huiquan AU - Khan, Mansoor Y1 - 2014/11/16/ PY - 2014 DA - 2014 Nov 16 KW - Powder KW - Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627963828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2014%29&rft.atitle=Applying+PAT+for+Pharmaceutical+Powder+Blending+Process%3A+Challenges+and+Opportunities&rft.au=Wu%2C+Huiquan%3BKhan%2C+Mansoor&rft.aulast=Wu&rft.aufirst=Huiquan&rft.date=2014-11-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Meeting+of+the+American+Institute+for+Chemical+Engineering+%28AIChE+2014%29&rft.issn=&rft_id=info:doi/ L2 - https://aiche.confex.com/aiche/2014/webprogram/meeting2014-11-16.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-31 N1 - Last updated - 2014-11-26 ER - TY - JOUR T1 - Temporal trends in mortality among people who use drugs compared with the general Dutch population differ by hepatitis C virus and HIV infection status AN - 1765976088; PQ0002559501 AB - Objectives: We aimed to identify temporal trends in all-cause and cause-specific mortality rates among people who use drugs (PWUD) compared with the general Dutch population and to determine whether mortality trends differed by hepatitis C virus (HCV)/HIV (co) infection status. Design: Longitudinal cohort study. Methods: Using data from the Amsterdam Cohort Studies among 1254 PWUD (1985-2012), all-cause and cause-specific standardized mortality ratios (SMRs) were calculated; SMRs were stratified by serological group (HCV/HIV-uninfected, HCV-monoinfected, and HCV/HIV-coinfected) and calendar period. Temporal trends were estimated using Poisson regression. Results: The overall all-cause SMR was 13.9 (95% confidence interval 12.6-15.3). The SMR significantly declined after 1996, especially due to a decline among women (P < 0.001). The highest SMR was observed among HCV/HIV-coinfected individuals during 1990-1996 (SMR 61.9, 95% confidence interval 50.4-76.0), which significantly declined after this period among women (P = 0.001). In contrast, SMR for HCV-monoinfected, and HCV/HIV-uninfected PWUD did not significantly change overtime. The SMR for non-natural deaths significantly declined (P= 0.007), whereas the SMR for HIV-related deaths was the highest during all calendar periods. Conclusions: We found evidence for declining all-cause mortality among PWUD compared with the general population rates. Those with HCV/HIV-coinfection showed the highest SMR. The decline in the SMR seems to be attributable to the decline in mortality among women. Mortality rates due to non-natural deaths came closer to those of the general population overtime. However, HIV-related deaths remain an important cause of mortality among PWUD when compared with the general Dutch population. This study reinforces the importance of harm-reduction interventions and HCV/HIV treatment to reduce mortality among PWUD. JF - AIDS AU - van Santen, Daniela K AU - van der Helm, Jannie J AU - Grady, Bart PX AU - de Vos, Anneke S AU - Kretzschmar, Mirjam EE AU - Stolte, Ineke G AU - Prins, Maria AD - Department of Research, Cluster Infectious Diseases, Public Health Service Amsterdam, Amsterdam, dvsanten@ggd.amsterdam.nl Y1 - 2014/11/13/ PY - 2014 DA - 2014 Nov 13 SP - 2589 EP - 2599 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 28 IS - 17 SN - 0269-9370, 0269-9370 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - causes of death KW - hepatitis C KW - HIV KW - people who use drugs KW - standardized mortality ratio KW - trends KW - Mortality KW - Acquired immune deficiency syndrome KW - Data processing KW - Intervention KW - Infection KW - ANE, Netherlands, Noord-Holland, Amsterdam KW - Hepatitis C virus KW - Human immunodeficiency virus KW - Standards KW - Hepatitis C KW - Drugs KW - V 22360:AIDS and HIV KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765976088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Temporal+trends+in+mortality+among+people+who+use+drugs+compared+with+the+general+Dutch+population+differ+by+hepatitis+C+virus+and+HIV+infection+status&rft.au=van+Santen%2C+Daniela+K%3Bvan+der+Helm%2C+Jannie+J%3BGrady%2C+Bart+PX%3Bde+Vos%2C+Anneke+S%3BKretzschmar%2C+Mirjam+EE%3BStolte%2C+Ineke+G%3BPrins%2C+Maria&rft.aulast=van+Santen&rft.aufirst=Daniela&rft.date=2014-11-13&rft.volume=28&rft.issue=17&rft.spage=2589&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2FQAD.0000000000000450 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Mortality; Data processing; Infection; Drugs; Acquired immune deficiency syndrome; Human immunodeficiency virus; Intervention; Standards; Hepatitis C; Hepatitis C virus; ANE, Netherlands, Noord-Holland, Amsterdam DO - http://dx.doi.org/10.1097/QAD.0000000000000450 ER - TY - JOUR T1 - Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. AN - 1609309343; 25086301 AB - While conventional parameters used to detect hepatotoxicity in drug safety assessment studies are generally informative, the need remains for parameters that can detect the potential for hepatotoxicity at lower doses and/or at earlier time points. Previous work has shown that metabolite profiling (metabonomics/metabolomics) can detect signals of potential hepatotoxicity in rats treated with doxorubicin at doses that do not elicit hepatotoxicity as monitored with conventional parameters. The current study extended this observation to the question of whether such signals could be detected in rats treated with compounds that can elicit hepatotoxicity in humans (i.e., drug-induced liver injury, DILI) but have not been reported to do so in rats. Nine compounds were selected on the basis of their known DILI potential, with six other compounds chosen as negative for DILI potential. A database of rat plasma metabolite profiles, MetaMap(®)Tox (developed by metanomics GmbH and BASF SE) was used for both metabolite profiles and mode of action (MoA) metabolite signatures for a number of known toxicities. Eight of the nine compounds with DILI potential elicited metabolite profiles that matched with MoA patterns of various rat liver toxicities, including cholestasis, oxidative stress, acetaminophen-type toxicity and peroxisome proliferation. By contrast, only one of the six non-DILI compounds showed a weak match with rat liver toxicity. These results suggest that metabolite profiling may indeed have promise to detect signals of hepatotoxicity in rats treated with compounds having DILI potential. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Mattes, W AU - Davis, K AU - Fabian, E AU - Greenhaw, J AU - Herold, M AU - Looser, R AU - Mellert, W AU - Groeters, S AU - Marxfeld, H AU - Moeller, N AU - Montoya-Parra, G AU - Prokoudine, A AU - van Ravenzwaay, B AU - Strauss, V AU - Walk, T AU - Kamp, H AD - PharmPoint Consulting, 17014 Hersperger Ln, Poolesville, MD 20837, USA. ; Toxicologic Pathology Associates, Jefferson, AR, USA. ; BASF SE, Ludwigshafen, Germany. ; National Center for Toxicological Research, FDA, Jefferson, AR, USA. ; Metanomics GmbH, Berlin, Germany. ; Metanomics Health GmbH, Berlin, Germany. ; BASF SE, Ludwigshafen, Germany. Electronic address: bennard.ravenzwaay@basf.com. Y1 - 2014/11/04/ PY - 2014 DA - 2014 Nov 04 SP - 467 EP - 478 VL - 230 IS - 3 KW - Triazoles KW - 0 KW - Neomycin KW - 1404-04-2 KW - Lamivudine KW - 2T8Q726O95 KW - Mannitol KW - 3OWL53L36A KW - Zidovudine KW - 4B9XT59T7S KW - nefazodone KW - 59H4FCV1TF KW - Valproic Acid KW - 614OI1Z5WI KW - Phenytoin KW - 6158TKW0C5 KW - Vancomycin KW - 6Q205EH1VU KW - Propylthiouracil KW - 721M9407IY KW - Flutamide KW - 76W6J0943E KW - Atropine KW - 7C0697DR9I KW - Captopril KW - 9G64RSX1XD KW - Streptomycin KW - Y45QSO73OB KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Rat plasma KW - Hepatotoxicity KW - Metabolomic KW - Animals KW - Triazoles -- toxicity KW - Phenytoin -- toxicity KW - Valproic Acid -- toxicity KW - Dose-Response Relationship, Drug KW - Atropine -- toxicity KW - Captopril -- toxicity KW - Methotrexate -- toxicity KW - Rats KW - Lamivudine -- toxicity KW - Vancomycin -- toxicity KW - Zidovudine -- toxicity KW - Propylthiouracil -- toxicity KW - Neomycin -- toxicity KW - Streptomycin -- toxicity KW - Rats, Wistar KW - Oxidative Stress -- drug effects KW - Flutamide -- toxicity KW - Female KW - Male KW - Mannitol -- toxicity KW - Chemical and Drug Induced Liver Injury -- blood KW - Metabolomics -- methods KW - Liver -- drug effects KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Liver -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609309343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Detection+of+hepatotoxicity+potential+with+metabolite+profiling+%28metabolomics%29+of+rat+plasma.&rft.au=Mattes%2C+W%3BDavis%2C+K%3BFabian%2C+E%3BGreenhaw%2C+J%3BHerold%2C+M%3BLooser%2C+R%3BMellert%2C+W%3BGroeters%2C+S%3BMarxfeld%2C+H%3BMoeller%2C+N%3BMontoya-Parra%2C+G%3BProkoudine%2C+A%3Bvan+Ravenzwaay%2C+B%3BStrauss%2C+V%3BWalk%2C+T%3BKamp%2C+H&rft.aulast=Mattes&rft.aufirst=W&rft.date=2014-11-04&rft.volume=230&rft.issue=3&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2014.07.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-28 N1 - Date created - 2014-10-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2014.07.021 ER - TY - JOUR T1 - An Evaluation of an Aftermarket Local Exhaust Ventilation Device for Suppressing Respirable Dust and Respirable Crystalline Silica Dust from Powered Saws AN - 1808733928; PQ0003494070 AB - The objective of this study was to quantify the respirable dust and respirable silica exposures of roofing workers using an electric-powered circular saw with an aftermarket local exhaust ventilation attachment to cut concrete roofing tiles. The study was conducted to determine whether the local exhaust ventilation attachment was able to control respirable dust and respirable silica exposure below occupational exposure limits (OELs). Time-integrated filter samples and direct reading respirable dust concentrations were evaluated. The local exhaust ventilation consisted of a shroud attached to the cutting plane of the saw; the shroud was then connected to a small electric axial fan, which is intended to collect dust at the point of generation. All sampling was conducted with the control in use. Roofers are defined as those individuals who only lay tiles. Cutters/roofers are defined as those workers who operate the powered saw to cut tiles and also lay tiles. Respirable dust from this evaluation ranged from 0.13 to 6.59 milligrams per cubic meter (mg/m super(3)) with a geometric mean of 0.38 mg/m super(3) for roofers and from 0.45 to 3.82 mg/m super(3) with a geometric mean of 1.84 mg/m super(3) for cutters/roofers. Cutters/roofers usually handle areas close to crevices, edges, or tips of the roof whereas roofers handle areas where complete tiles can be placed. The respirable dust exposures for all cutters/roofers indicated concentrations exceeding the Occupational Safety and Health Administration's (OSHA) permissible exposure limit (PEL) for respirable dust containing silica; it was also exceeded for some of the roofers. The respirable silica concentrations ranged from 0.04 to 0.15 mg/m super(3) with a geometric mean of 0.09 mg/m super(3) for roofers, and from 0.13 to 1.21 mg/m super(3) with a geometric mean of 0.48 mg/m super(3) for cutters/roofers. As with respirable dust, the respirable silica exposures for cutters/roofers were higher than the exposures for roofers. JF - Journal of Occupational and Environmental Hygiene AU - Garcia, Alberto AU - Jones, Erica AU - Echt, Alan S AU - Hall, Ronald M AD - National Institute for Occupational Safety and Health (NIOSH), Division of Applied Research and Technology (DART), Cincinnati, Ohio Y1 - 2014/11/02/ PY - 2014 DA - 2014 Nov 02 SP - D200 EP - D207 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 11 IS - 11 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Federal regulations KW - Safety regulations KW - Ventilation KW - Occupational safety KW - Dust KW - Exhausts KW - Filters KW - Workers KW - Silica KW - Language KW - Sampling KW - Occupational exposure KW - Environmental hygiene KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808733928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=An+Evaluation+of+an+Aftermarket+Local+Exhaust+Ventilation+Device+for+Suppressing+Respirable+Dust+and+Respirable+Crystalline+Silica+Dust+from+Powered+Saws&rft.au=Garcia%2C+Alberto%3BJones%2C+Erica%3BEcht%2C+Alan+S%3BHall%2C+Ronald+M&rft.aulast=Garcia&rft.aufirst=Alberto&rft.date=2014-11-02&rft.volume=11&rft.issue=11&rft.spage=D200&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2014.955182 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Filters; Workers; Silica; Ventilation; Language; Sampling; Occupational exposure; Dust; Environmental hygiene; Exhausts; Federal regulations; Safety regulations; Occupational safety DO - http://dx.doi.org/10.1080/15459624.2014.955182 ER - TY - JOUR T1 - Pharmaceutical Dust Exposure at Pharmacies Using Automatic Dispensing Machines: A Preliminary Study AN - 1808708038; PQ0003494067 AB - Automatic dispensing machines (ADMs) used in pharmacies concentrate and dispense large volumes of pharmaceuticals, including uncoated tablets that can shed dust. We evaluated 43 employees' exposures to pharmaceutical dust at three pharmacies where ADMs were used. We used an optical particle counter to identify tasks that generated pharmaceutical dust. We collected 72 inhalable dust air samples in or near the employees' breathing zones. In addition to gravimetric analysis, our contract laboratory used internal methods involving liquid chromatography to analyze these samples for active pharmaceutical ingredients (APIs) and/or lactose, an inactive filler in tablets. We had to choose samples for these additional analyses because many methods used different extraction solvents. We selected 57 samples for analysis of lactose. We used real-time particle monitoring results, observations, and information from employees on the dustiness of pharmaceuticals to select 28 samples (including 13 samples that were analyzed for lactose) for analysis of specific APIs. Pharmaceutical dust was generated during a variety of tasks like emptying and refilling of ADM canisters. Using compressed air to clean canisters and manual count machines produced the overall highest peak number concentrations (19,000-580,000 particles/L) of smallest particles (count median aerodynamic diameter less than or equal to 2 mu m). Employees who refilled, cleaned, or repaired ADM canisters, or hand filled prescriptions were exposed to higher median air concentrations of lactose (5.0-12 mu g/m super(3)) than employees who did other jobs (0.04-1.3 mu g/m super(3)), such as administrative/office work, labeling/packaging, and verifying prescriptions. We detected 10 APIs in air, including lisinopril, a drug prescribed for high blood pressure, levothyroxine, a drug prescribed for hypothyroidism, and methotrexate, a hazardous drug prescribed for cancer and other disorders. Three air concentrations of lisinopril (1.8-2.7 mu g/m super(3)) exceeded the lower bound of the manufacturer's hazard control band (1-10 mu g/m super(3)). All other API air concentrations were below applicable occupational exposure limits. Our findings indicate that some pharmacy employees are exposed to multiple APIs and that measures are needed to control those exposures. JF - Journal of Occupational and Environmental Hygiene AU - Fent, Kenneth W AU - Durgam, Srinivas AU - Mueller, Charles AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health (NIOSH), Cincinnati, Ohio Y1 - 2014/11/02/ PY - 2014 DA - 2014 Nov 02 SP - 695 EP - 705 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 11 IS - 11 SN - 1545-9624, 1545-9624 KW - Toxicology Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Inhalation KW - Particle counters KW - Contracts KW - Respiration KW - Tablets KW - Particulates KW - Dust KW - Air sampling KW - Thyroxine KW - Methotrexate KW - Drugs KW - Occupational exposure KW - Packaging KW - Environmental hygiene KW - Lactose KW - Solvents KW - Hand KW - Cancer KW - Gravimetric analysis KW - Liquid chromatography KW - Hypothyroidism KW - Pharmaceuticals KW - Hypertension KW - X 24370:Natural Toxins KW - H 1000:Occupational Safety and Health KW - ENA 01:Air Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808708038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Hygiene&rft.atitle=Pharmaceutical+Dust+Exposure+at+Pharmacies+Using+Automatic+Dispensing+Machines%3A+A+Preliminary+Study&rft.au=Fent%2C+Kenneth+W%3BDurgam%2C+Srinivas%3BMueller%2C+Charles&rft.aulast=Fent&rft.aufirst=Kenneth&rft.date=2014-11-02&rft.volume=11&rft.issue=11&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Hygiene&rft.issn=15459624&rft_id=info:doi/10.1080%2F15459624.2014.918983 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Lactose; Respiration; Tablets; Solvents; Hand; Dust; Cancer; Liquid chromatography; Thyroxine; Pharmaceuticals; Hypothyroidism; Methotrexate; Occupational exposure; Hypertension; Environmental hygiene; Inhalation; Particle counters; Contracts; Particulates; Gravimetric analysis; Air sampling; Drugs; Packaging DO - http://dx.doi.org/10.1080/15459624.2014.918983 ER - TY - JOUR T1 - Effects of comparative claims in prescription drug direct-to-consumer advertising on consumer perceptions and recall AN - 1738476597; 201539150 AB - Although pharmaceutical companies cannot make comparative claims in direct-to-consumer (DTC) ads for prescription drugs without substantial evidence, the U.S. Food and Drug Administration permits some comparisons based on labeled attributes of the drug, such as dosing. Researchers have examined comparative advertising for packaged goods; however, scant research has examined comparative DTC advertising. We conducted two studies to determine if comparative claims in DTC ads influence consumers' perceptions and recall of drug information. In Experiment 1, participants with osteoarthritis (n = 1934) viewed a fictitious print or video DTC ad that had no comparative claim or made an efficacy comparison to a named or unnamed competitor. Participants who viewed print (but not video) ads with named competitors had greater efficacy and lower risk perceptions than participants who viewed unnamed competitor and noncomparative ads. In Experiment 2, participants with high cholesterol or high body mass index (n = 5317) viewed a fictitious print or video DTC ad that had no comparative claim or made a comparison to a named or unnamed competitor. We varied the type of comparison (of indication, dosing, or mechanism of action) and whether the comparison was accompanied by a visual depiction. Participants who viewed print and video ads with named competitors had greater efficacy perceptions than participants who viewed unnamed competitor and noncomparative ads. Unlike Experiment 1, named competitors in print ads resulted in higher risk perceptions than unnamed competitors. In video ads, participants who saw an indication comparison had greater benefit recall than participants who saw dosing or mechanism of action comparisons. In addition, visual depictions of the comparison decreased risk recall for video ads. Overall, the results suggest that comparative claims in DTC ads could mislead consumers about a drug's efficacy and risk; therefore, caution should be used when presenting comparative claims in DTC ads. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - O'Donoghue, Amie C AU - Williams, Pamela A AU - Sullivan, Helen W AU - Boudewyns, Vanessa AU - Squire, Claudia AU - Willoughby, Jessica Fitts AD - Office of Prescription Drug Promotion, Center for Drug Evaluation and Research, Food and Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1 EP - 11 PB - Elsevier Science, Amsterdam The Netherlands VL - 120 SN - 0277-9536, 0277-9536 KW - United States Direct-to-consumer (DTC) advertisements Prescription drugs Marketing Comparative advertising Perceived risk Communication KW - Body Weight KW - Risk KW - Consumers KW - Videotape Recordings KW - Advertising KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738476597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Effects+of+comparative+claims+in+prescription+drug+direct-to-consumer+advertising+on+consumer+perceptions+and+recall&rft.au=O%27Donoghue%2C+Amie+C%3BWilliams%2C+Pamela+A%3BSullivan%2C+Helen+W%3BBoudewyns%2C+Vanessa%3BSquire%2C+Claudia%3BWilloughby%2C+Jessica+Fitts&rft.aulast=O%27Donoghue&rft.aufirst=Amie&rft.date=2014-11-01&rft.volume=120&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.08.039 LA - English DB - Sociological Abstracts N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Videotape Recordings; Risk; Consumers; Advertising; Body Weight DO - http://dx.doi.org/10.1016/j.socscimed.2014.08.039 ER - TY - JOUR T1 - Effects of comparative claims in prescription drug direct-to-consumer advertising on consumer perceptions and recall AN - 1738475364; 201507453 AB - Although pharmaceutical companies cannot make comparative claims in direct-to-consumer (DTC) ads for prescription drugs without substantial evidence, the U.S. Food and Drug Administration permits some comparisons based on labeled attributes of the drug, such as dosing. Researchers have examined comparative advertising for packaged goods; however, scant research has examined comparative DTC advertising. We conducted two studies to determine if comparative claims in DTC ads influence consumers' perceptions and recall of drug information. In Experiment 1, participants with osteoarthritis (n = 1934) viewed a fictitious print or video DTC ad that had no comparative claim or made an efficacy comparison to a named or unnamed competitor. Participants who viewed print (but not video) ads with named competitors had greater efficacy and lower risk perceptions than participants who viewed unnamed competitor and noncomparative ads. In Experiment 2, participants with high cholesterol or high body mass index (n = 5317) viewed a fictitious print or video DTC ad that had no comparative claim or made a comparison to a named or unnamed competitor. We varied the type of comparison (of indication, dosing, or mechanism of action) and whether the comparison was accompanied by a visual depiction. Participants who viewed print and video ads with named competitors had greater efficacy perceptions than participants who viewed unnamed competitor and noncomparative ads. Unlike Experiment 1, named competitors in print ads resulted in higher risk perceptions than unnamed competitors. In video ads, participants who saw an indication comparison had greater benefit recall than participants who saw dosing or mechanism of action comparisons. In addition, visual depictions of the comparison decreased risk recall for video ads. Overall, the results suggest that comparative claims in DTC ads could mislead consumers about a drug's efficacy and risk; therefore, caution should be used when presenting comparative claims in DTC ads. [Copyright Elsevier Ltd.] JF - Social Science & Medicine AU - O'Donoghue, Amie C AU - Williams, Pamela A AU - Sullivan, Helen W AU - Boudewyns, Vanessa AU - Squire, Claudia AU - Willoughby, Jessica Fitts AD - Office of Prescription Drug Promotion, Center for Drug Evaluation and Research, Food and Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD 20993-0002, USA Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1 EP - 11 PB - Elsevier Science, Amsterdam The Netherlands VL - 120 SN - 0277-9536, 0277-9536 KW - United States Direct-to-consumer (DTC) advertisements Prescription drugs Marketing Comparative advertising Perceived risk Communication KW - Body Weight KW - Risk KW - Consumers KW - Videotape Recordings KW - Advertising KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1738475364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Effects+of+comparative+claims+in+prescription+drug+direct-to-consumer+advertising+on+consumer+perceptions+and+recall&rft.au=O%27Donoghue%2C+Amie+C%3BWilliams%2C+Pamela+A%3BSullivan%2C+Helen+W%3BBoudewyns%2C+Vanessa%3BSquire%2C+Claudia%3BWilloughby%2C+Jessica+Fitts&rft.aulast=O%27Donoghue&rft.aufirst=Amie&rft.date=2014-11-01&rft.volume=120&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.08.039 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Videotape Recordings; Risk; Consumers; Advertising; Body Weight DO - http://dx.doi.org/10.1016/j.socscimed.2014.08.039 ER - TY - JOUR T1 - Evaluation of a New Handheld Instrument for the Detection of Counterfeit Artesunate by Visual Fluorescence Comparison AN - 1722169982; PQ0002099251 AB - There is an urgent need for accurate and inexpensive handheld instruments for the evaluation of medicine quality in the field. A blinded evaluation of the diagnostic accuracy of the Counterfeit Detection Device 3 (CD-3), developed by the US Food and Drug Administration Forensic Chemistry Center, was conducted in the Lao People's Democratic Republic. Two hundred three samples of the oral antimalarial artesunate were compared with authentic products using the CD-3 by a trainer and two trainees. The specificity (95% confidence interval [95% CI]), sensitivity (95% CI), positive predictive value (95% CI), and negative predictive value (95% CI) of the CD-3 for detecting counterfeit (falsified) artesunate were 100% (93.8-100%), 98.4% (93.8-99.7%), 100% (96.2-100%), and 97.4% (90.2-99.6%), respectively. Interobserver agreement for 203 samples of artesunate was 100%. The CD-3 holds promise as a relatively inexpensive and easy to use instrument for field evaluation of medicines, potentially empowering drug inspectors, customs agents, and pharmacists. JF - American Journal of Tropical Medicine and Hygiene AU - Ranieri, Nicola AU - Tabernero, Patricia AU - Green, Michael D AU - Verbois, Leigh AU - Herrington, James AU - Sampson, Eric AU - Satzger, R Duane AU - Phonlavong, Chindaphone AU - Thao, Khamxay AU - Newton, Paul N AU - Witkowski, Mark R AD - Forensic Chemistry Center, US Food and Drug Administration, Cincinnati, Ohio, Nicola.Ranieri@fda.hhs.gov Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 920 EP - 924 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 91 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Prediction KW - Fluorescence KW - Specificity KW - Forensic science KW - artesunate KW - Hygiene KW - Drugs KW - K 03340:Effects of Physical & Chemical Factors KW - Q1 08563:Fishing gear and methods KW - Q5 08524:Public health, medicines, dangerous organisms KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722169982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Evaluation+of+a+New+Handheld+Instrument+for+the+Detection+of+Counterfeit+Artesunate+by+Visual+Fluorescence+Comparison&rft.au=Ranieri%2C+Nicola%3BTabernero%2C+Patricia%3BGreen%2C+Michael+D%3BVerbois%2C+Leigh%3BHerrington%2C+James%3BSampson%2C+Eric%3BSatzger%2C+R+Duane%3BPhonlavong%2C+Chindaphone%3BThao%2C+Khamxay%3BNewton%2C+Paul+N%3BWitkowski%2C+Mark+R&rft.aulast=Ranieri&rft.aufirst=Nicola&rft.date=2014-11-01&rft.volume=91&rft.issue=5&rft.spage=920&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.13-0644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Prediction; Fluorescence; Specificity; Hygiene; Drugs; Forensic science; artesunate DO - http://dx.doi.org/10.4269/ajtmh.13-0644 ER - TY - JOUR T1 - Simulation Exercises to Strengthen Polio Outbreak Preparedness: Experience of the World Health Organization European Region AN - 1687688977; PQ0001574031 AB - Background. Poliovirus importations and related outbreaks continue to occur in polio-free countries, including those in the World Health Organization (WHO) European Region. National preparedness plans for responding to poliovirus introduction are insufficient in many countries of the European Region. We describe a series of polio outbreak simulation exercises that were implemented to formally test polio outbreak preparedness plans in the European Region. Methods. We designed and implemented the exercises, reviewed the results, made recommendations, and assessed the role of outbreak simulation exercises in maintaining regional polio-free status. In addition, we performed a comprehensive review of the national plans of all WHO Member States in the European Region. Results. Three exercises, delivered during 2011-2013 (for the Balkans, United Kingdom, and the Caucasus and Ukraine), revealed that participating countries were generally prepared for poliovirus introduction, but the level of preparedness needed improvement. The areas in particular need of strengthening were national preparedness plans, initial response, plans for securing vaccine supply, and communications. Conclusions. Polio outbreak simulation exercises can be valuable tools to help maintain polio-free status and should be extended to other high-risk countries and subnational areas in the European Region and elsewhere. JF - Journal of Infectious Diseases AU - Moulsdale, Hilary J AU - Khetsuriani, Nino AU - Deshevoi, Sergei AU - Butler, Robb AU - Simpson, John AU - Salisbury, David AD - Emergency Response Department, Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, United Kingdom, hilary.moulsdale@phe.gov.uk Y1 - 2014/11/01/ PY - 2014 DA - 2014 Nov 01 SP - S208 EP - S215 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 210 SN - 0022-1899, 0022-1899 KW - Risk Abstracts; Health & Safety Science Abstracts; Virology & AIDS Abstracts KW - poliovirus KW - polio outbreak simulation exercise (POSE) KW - preparedness exercise KW - polio eradication KW - Poliovirus KW - Ukraine KW - Communication KW - Simulation KW - Importation KW - Physical training KW - Communications KW - Infectious diseases KW - Reviews KW - Risk groups KW - Europe, Balkans KW - Outbreaks KW - Vaccines KW - V 22300:Methods KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1687688977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Simulation+Exercises+to+Strengthen+Polio+Outbreak+Preparedness%3A+Experience+of+the+World+Health+Organization+European+Region&rft.au=Moulsdale%2C+Hilary+J%3BKhetsuriani%2C+Nino%3BDeshevoi%2C+Sergei%3BButler%2C+Robb%3BSimpson%2C+John%3BSalisbury%2C+David&rft.aulast=Moulsdale&rft.aufirst=Hilary&rft.date=2014-11-01&rft.volume=210&rft.issue=&rft.spage=S208&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/10.1093%2Finfdis%2Fjiu120 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-04-13 N1 - SubjectsTermNotLitGenreText - Reviews; Communication; Risk groups; Vaccines; Importation; Physical training; Poliovirus; Communications; Infectious diseases; Simulation; Outbreaks; Ukraine; Europe, Balkans DO - http://dx.doi.org/10.1093/infdis/jiu120 ER - TY - JOUR T1 - Institutional Decision Making: Empowering of Health System and Economic Transformation AN - 1673612454 AB - Organized medicine (OM) is an institution built to defend the American health care system of the 20th century. The institutional structures that it employed, however, operated mechanically and independently of its practitioner base, which drew from physician and nonphysician health professions. This article suggests that OMʼs institutional structures were founded and defended by a "logic of confidence," which initially served as a buffer against external socioeconomic pressures. The institutional structures of OM came to be treated systemically as rules (e.g.,"Trust me, Iʼm a doctor" and "The doctor knows best"), biasing and guiding organizational decision making and activities. OM so effectively promoted its rules that they were installed as powerful myths in the American psyche. The author explains how OMʼs failure to adapt has impelled the strongest representatives of all health professions to resist top-down decoupling in favor of bottom-up identity maturation, applying a new "logic of appropriateness." JF - The American Psychologist AU - McGuinness, Kevin M AD - Health Resources and Services Administration, United States Public Health Service, Bureau of Health Workforce, 5600 Fishers Lane, Room 8-73, Rockville, MD 20857 ; Health Resources and Services Administration, United States Public Health Service, Bureau of Health Workforce, 5600 Fishers Lane, Room 8-73, Rockville, MD 20857 Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 817 EP - 827 CY - Washington PB - American Psychological Association VL - 69 IS - 8 SN - 0003-066X KW - Psychology KW - bias KW - decision making KW - health reform KW - public health KW - behavioral health KW - 20th century KW - Decision making KW - Health care KW - Health professionals KW - Identity KW - Maturation KW - Myths KW - Transformation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1673612454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Psychologist&rft.atitle=Institutional+Decision+Making%3A+Empowering+of+Health+System+and+Economic+Transformation&rft.au=McGuinness%2C+Kevin+M&rft.aulast=McGuinness&rft.aufirst=Kevin&rft.date=2014-11-01&rft.volume=69&rft.issue=8&rft.spage=817&rft.isbn=&rft.btitle=&rft.title=The+American+Psychologist&rft.issn=0003066X&rft_id=info:doi/10.1037%2Fa0037620 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-03-31 N1 - Last updated - 2016-05-16 DO - http://dx.doi.org/10.1037/a0037620 ER - TY - JOUR T1 - Sex Moderates Associations Between Perceptions of the Physical and Social Environments and Physical Activity in Youth AN - 1665160397 AB - Purpose. To determine if the sex of the child moderates the relationships between perceptions of the physical/social environments and moderale to vigorous physical activity (MVPA) in youth. Design. Cross-sectional. Setting. North Carolina. Subjects. A final sample of 711 children, 8 to 17 years of age, was available for analysis. Measures. Self-reported presence of environmental factors previously identified to be associated xuilh physical activity in youth was collected via survey. Daily MVPA was assessed via accelerometry for a minimum of 4 days. Analysis. Multilevel linear regression models were employed, adjusted for clustering at the county and individual level. MVPA was first regressed onto sex and environmental perception items while controlling for grade and race. The interaction term behueen sex and environmental perception was then added to the model. Results. A significant positive association was observed in the first models between MVPA and two items related to parent permission to (1) walk and (2) ride a bike in the neighborhood. These effects were fully moderated by sex, with males indicating"yes" on these items exhibiting 6.87 and 5.21 more minutes of MVPA (respectively) than males indicating "no." Conclusion. Environmental perceptions appear to be related to MVPA, but this relationship is present only in males. Future research should be conducted to identify modifiable social and physical characteristics that are associated with MVPA in females. JF - American Journal of Health Promotion : AJHP. AU - Moore, Justin B AU - Beets, Michael W AU - Kaczynski, Andrew T AU - Besenyi, Gina M AU - Morris, Sara F AU - Kolbe, Mary Bea AD - Department of Health Promotion, Education, and Behavior, and Office of Public Health Practice, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Room 216, Columbia, SC 29208 ; Department of Exercise Science, University of South Carolina, Columbia, South Carolina ; Department of Health Promotion, Education, and Behavior, Arnold School of Public Health ; Division of Public Health ; Physical Activity and Nutrition Branch, Division of Public Health, North Carolina Department of Health and Human Services, Raleigh, North Carolina ; Department of Health Promotion, Education, and Behavior, and Office of Public Health Practice, Arnold School of Public Health, University of South Carolina, 800 Sumter Street, Room 216, Columbia, SC 29208 Y1 - 2014///Nov/Dec PY - 2014 DA - Nov/Dec 2014 SP - 132 EP - 135 CY - Birmingham PB - Mosby-Year Book, Inc. VL - 29 IS - 2 SN - 0890-1171 KW - Physical Fitness And Hygiene KW - Motor Activity KW - Environment KW - Child KW - Accelerometry KW - Prevention Research KW - Children KW - Clustering KW - Environmental aspects KW - Men KW - Moderated KW - Neighbourhoods KW - Perceptions KW - Permission KW - Physical activity KW - Race KW - Young people KW - North Carolina UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665160397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Promotion+%3A+AJHP.&rft.atitle=Sex+Moderates+Associations+Between+Perceptions+of+the+Physical+and+Social+Environments+and+Physical+Activity+in+Youth&rft.au=Moore%2C+Justin+B%3BBeets%2C+Michael+W%3BKaczynski%2C+Andrew+T%3BBesenyi%2C+Gina+M%3BMorris%2C+Sara+F%3BKolbe%2C+Mary+Bea&rft.aulast=Moore&rft.aufirst=Justin&rft.date=2014-11-01&rft.volume=29&rft.issue=2&rft.spage=132&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Promotion+%3A+AJHP.&rft.issn=08901171&rft_id=info:doi/10.4278%2Fajhp.121023-ARB-516 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - North Carolina DO - http://dx.doi.org/10.4278/ajhp.121023-ARB-516 ER - TY - JOUR T1 - The peer relationships of girls with ASD at school: comparison to boys and girls with and without ASD AN - 1665151069 AB - Background This study examines the social relationships of elementary school children with high-functioning autism, focusing on how gender relates to social preferences and acceptance, social connections, reciprocal friendships, and rejection. Method Peer nomination data were analyzed for girls with and without ASD ( n = 50) and boys with and without ASD ( n = 50). Girls and boys with ASD were matched by age, gender, and IQ. Each child with ASD was matched by age and gender to a typically developing classmate. Results Consistent with typically developing populations, children with ASD preferred, were accepted by, and primarily socialized with same-gender friends. With fewer nominations and social relationships, girls and boys with ASD appear more socially similar to each other than to the same-gender control group. Additionally, girls and boys with ASD showed higher rates of social exclusion than their typically developing peers. However, boys with ASD were more overtly socially excluded compared to girls with ASD, who seemed to be overlooked, rather than rejected. Conclusions Our data suggest a number of interesting findings in the social relationships of children with ASD in schools. Like typically developing populations, children with ASD identify with their own gender when socializing and choosing friends. But given the social differences between genders, it is likely that girls with ASD are experiencing social challenges that are different from boys with ASD. Therefore, gender is an important environmental factor to consider when planning social skills interventions at school. JF - Journal of Child Psychology and Psychiatry AU - Dean, Michelle AU - Kasari, Connie AU - Shih, Wendy AU - Frankel, Fred AU - Whitney, Rondalyn AU - Landa, Rebecca AU - Lord, Catherine AU - Orlich, Felice AU - King, Bryan AU - Harwood, Robin AD - Center for Autism Research and Treatment, University of California, Los Angeles, CA, USA. ; Center for Autism Research and Treatment, University of California, Los Angeles, CA, USA., Human Development and Psychology, University of California, Los Angeles, CA, USA. ; Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA. ; Center for Autism and the Developing Brain, Weill Cornell Medical College, New York, NY, USA. ; Seattle Childrenʼs Hospital, University of Washington, Seattle, WC, USA. ; Health Resources and Services Administration, Rockville, MD, USA. ; Center for Autism Research and Treatment, University of California, Los Angeles, CA, USA. Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1218 EP - 1225 CY - Malden PB - Wiley Subscription Services, Inc. VL - 55 IS - 11 KW - Psychology KW - Acceptance KW - Boys KW - Girls KW - Rejection KW - Same sex KW - Social exclusion KW - Social relationships KW - Social skills KW - Autism KW - Autistic children KW - Autistic spectrum disorders KW - Children KW - Friends KW - Friendships KW - Gender KW - Gender differences KW - High functioning KW - Intelligence quotient KW - Interventions KW - Nominations KW - Peer relationships UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665151069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=The+peer+relationships+of+girls+with+ASD+at+school%3A+comparison+to+boys+and+girls+with+and+without+ASD&rft.au=Dean%2C+Michelle%3BKasari%2C+Connie%3BShih%2C+Wendy%3BFrankel%2C+Fred%3BWhitney%2C+Rondalyn%3BLanda%2C+Rebecca%3BLord%2C+Catherine%3BOrlich%2C+Felice%3BKing%2C+Bryan%3BHarwood%2C+Robin&rft.aulast=Dean&rft.aufirst=Michelle&rft.date=2014-11-01&rft.volume=55&rft.issue=11&rft.spage=1218&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Psychology+and+Psychiatry&rft.issn=&rft_id=info:doi/10.1111%2Fjcpp.12242 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-01-09 N1 - Last updated - 2016-08-16 DO - http://dx.doi.org/10.1111/jcpp.12242 ER - TY - JOUR T1 - H5 N-terminal beta sheet promotes oligomerization of H7-HA1 that induces better antibody affinity maturation and enhanced protection against H7N7 and H7N9 viruses compared to inactivated influenza vaccine AN - 1664206108; PQ0001196988 AB - Initiation of mass vaccination is critical in response to influenza pandemic. There is an urgent need of a simple, rapid method for production of influenza vaccine that is more effective than current traditional influenza vaccines. Recent H7N9 transmissions to humans in China with high morbidity/mortality initiated extensive vaccine evaluation. We produced the HA1 domains (amino acids 1-320) from H7N9 and H7N7 strains in E. coli. Both were found to contain primarily monomers/trimers with low oligomeric content. However, when residues from the N-terminal beta sheet (first 8 amino acid) of H7 HA1 domains were swapped with the corresponding amino acids from H5N1, functional oligomeric H7 HA1 were produced (HA1-DS), demonstrating strong receptor binding and hemagglutination. In rabbits, the HA1-DS from either H7N9 or H7N7 generated high neutralization titers against both homologous and heterologous H7 strains, superior to the unmodified H7 HA1 proteins. In ferrets, HA1-DS from H7N7 elicited higher (and faster) HI titers, better protected ferrets from lethality, weight loss, and reduced viral loads following challenge with wild-type highly pathogenic H7N7 virus compared with inactivated H7N7 subunit vaccine. HA1-DS vaccinated ferrets were also better protected from weight loss after challenge with the heterologous H7N9 virus compared with inactivated H7N7 subunit vaccine. Importantly, the H7N7 HA1-DS vaccine induced antibody affinity maturation far superior to the inactivated H7N7 subunit vaccine, which strongly correlated with control of viral loads in the nasal washes after challenge with either H7N7 or H7N9 strains. We conclude that N-terminus beta sheet domain-swap can be used to produce stable functional oligomeric forms of better recombinant HA1 vaccines in simple, inexpensive bacterial system for rapid response to emerging pandemic threat for the global population. JF - Vaccine AU - Khurana, Surender AU - Coyle, Elizabeth M AU - Verma, Swati AU - King, Lisa R AU - Manischewitz, Jody AU - Crevar, Corey J AU - Carter, Donald M AU - Ross, Ted M AU - Golding, Hana AD - Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, Silver Spring, MD 20903, USA Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 6421 EP - 6432 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 32 IS - 48 SN - 0264-410X, 0264-410X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Influenza KW - Vaccine KW - Hemagglutinin KW - HA1 KW - Antibody KW - Affinity KW - Immune Response KW - Ferrets KW - Bacteria KW - protein KW - Pandemic KW - H7N7 KW - H7N9 KW - Viruses KW - Population dynamics KW - Hemagglutination KW - Morbidity KW - N-Terminus KW - pandemics KW - Mustela KW - Escherichia coli KW - Neutralization KW - Mortality KW - Amino acids KW - Residues KW - Oligomerization KW - Monomers KW - Antibodies KW - Lethality KW - Proteins KW - China, People's Rep. KW - Vaccines KW - F 06905:Vaccines KW - V 22320:Replication KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1664206108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=H5+N-terminal+beta+sheet+promotes+oligomerization+of+H7-HA1+that+induces+better+antibody+affinity+maturation+and+enhanced+protection+against+H7N7+and+H7N9+viruses+compared+to+inactivated+influenza+vaccine&rft.au=Khurana%2C+Surender%3BCoyle%2C+Elizabeth+M%3BVerma%2C+Swati%3BKing%2C+Lisa+R%3BManischewitz%2C+Jody%3BCrevar%2C+Corey+J%3BCarter%2C+Donald+M%3BRoss%2C+Ted+M%3BGolding%2C+Hana&rft.aulast=Khurana&rft.aufirst=Surender&rft.date=2014-11-01&rft.volume=32&rft.issue=48&rft.spage=6421&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2014.09.049 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Number of references - 20 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - Monomers; Influenza; Mortality; pandemics; Antibodies; Lethality; Amino acids; Oligomerization; Vaccines; Hemagglutination; Morbidity; N-Terminus; Residues; Viruses; Proteins; Population dynamics; Neutralization; Mustela; Escherichia coli; China, People's Rep. DO - http://dx.doi.org/10.1016/j.vaccine.2014.09.049 ER - TY - JOUR T1 - Detection and functionality of the CdtB, PltA, and PltB from Salmonella enterica serovar Javiana AN - 1660412290; PQ0001030403 AB - Salmonella infection is one of the major foodborne illnesses in the United States. Several Gram-negative bacterial pathogens, including Salmonella Typhi, produce cytolethal distending toxin (CDT), which arrests growth, induces apoptosis of infected host cells and extends persistence of pathogenic bacteria in the host. The aim of this study was to characterize the functionality of CDT (cdtB, pltA and pltB) from nontyphoidal Salmonella isolates. Fifty Salmonella enterica serovar Javiana isolates from food, environmental, and clinical samples were screened for cdtB, pltA, and pltB genes by PCR, and all were positive for all three genes. Nucleotide sequence analysis of all amplified PCR products showed 100% identity to S. Typhi cdtB. To understand the roles of CdtB, PltA, and PltB in S. Javiana, cdtB, pltA, and pltB deletion mutants were constructed using a lambda Red-based recombination system. In vitro-cultured HeLa cell lines were infected with a wild-type strain and its isogenic Delta cdtB, Delta pltA, and Delta pltB to determine whether the strains of S. Javiana are responsible for invasion and cytolethal distending intoxication, including cell cycle arrest, cytoplasmic distension, and nuclear enlargement of host target cells. The results showed that HeLa cells infected with S. Javiana wild type were arrested in G sub(2)/M and had distended cytoplasm and nuclei that were larger than those infected with S. Javiana Delta cdtB and Delta pltA strains. The S. Javiana Delta pltB strain retained the ability to induce cytoplasmic distension and cell cycle arrest, whereas the complemented Delta cdtB and Delta pltA S. Javiana strains showed activity like the wild-type strains. CdtB and pltA from S. Javiana had apparent effects on the distension of both cytoplasm and nucleus as well as cell cycle arrest of HeLa cell lines after 72 h of infection. Our data show a significant difference between the wild-type cdtB strain and its isogenic Delta cdtB for invasion of the cell lines. Therefore, CdtB produced from S. Javiana strains may play an important role in pathogenesis in host cells. The cytolethal distending toxin is an important toxin found in several Gram-negative pathogens. In this study we report for the first time the functionality of cdtB, pltA and pltB in non-typhoidal S. Javiana during infection in HeLa cell lines. JF - Pathogens and Disease AU - Mezal, Ezat H AU - Bae, Dongryeoul AU - Khan, Ashraf A AD - Division of Microbiology, National Center for Toxicological Research, U. S. Food and Drug Administration, Jefferson, AR, USA. Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 95 EP - 103 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 England VL - 72 IS - 2 SN - 2049-632X, 2049-632X KW - Microbiology Abstracts B: Bacteriology KW - Intoxication KW - cytolethal distending toxin KW - Data processing KW - Distension KW - Deletion mutant KW - Apoptosis KW - Salmonella typhi KW - Nucleotide sequence KW - Food KW - Cell cycle KW - Pathogens KW - Infection KW - Recombination KW - Salmonella enterica KW - Cytoplasm KW - Polymerase chain reaction KW - Nuclei KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660412290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pathogens+and+Disease&rft.atitle=Detection+and+functionality+of+the+CdtB%2C+PltA%2C+and+PltB+from+Salmonella+enterica+serovar+Javiana&rft.au=Mezal%2C+Ezat+H%3BBae%2C+Dongryeoul%3BKhan%2C+Ashraf+A&rft.aulast=Mezal&rft.aufirst=Ezat&rft.date=2014-11-01&rft.volume=72&rft.issue=2&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Pathogens+and+Disease&rft.issn=2049632X&rft_id=info:doi/10.1111%2F2049-632X.12191 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Intoxication; cytolethal distending toxin; Apoptosis; Deletion mutant; Distension; Data processing; Food; Nucleotide sequence; Cell cycle; Pathogens; Infection; Recombination; Cytoplasm; Polymerase chain reaction; Nuclei; Salmonella typhi; Salmonella enterica DO - http://dx.doi.org/10.1111/2049-632X.12191 ER - TY - JOUR T1 - Effects of comparative claims in prescription drug direct-to-consumer advertising on consumer perceptions and recall AN - 1660030777; 4650005 AB - Although pharmaceutical companies cannot make comparative claims in direct-to-consumer (DTC) ads for prescription drugs without substantial evidence, the U.S. Food and Drug Administration permits some comparisons based on labeled attributes of the drug, such as dosing. Researchers have examined comparative advertising for packaged goods; however, scant research has examined comparative DTC advertising. We conducted two studies to determine if comparative claims in DTC ads influence consumers' perceptions and recall of drug information. In Experiment 1, participants with osteoarthritis (n = 1934) viewed a fictitious print or video DTC ad that had no comparative claim or made an efficacy comparison to a named or unnamed competitor. Participants who viewed print (but not video) ads with named competitors had greater efficacy and lower risk perceptions than participants who viewed unnamed competitor and noncomparative ads. In Experiment 2, participants with high cholesterol or high body mass index (n = 5317) viewed a fictitious print or video DTC ad that had no comparative claim or made a comparison to a named or unnamed competitor. We varied the type of comparison (of indication, dosing, or mechanism of action) and whether the comparison was accompanied by a visual depiction. Participants who viewed print and video ads with named competitors had greater efficacy perceptions than participants who viewed unnamed competitor and noncomparative ads. Unlike Experiment 1, named competitors in print ads resulted in higher risk perceptions than unnamed competitors. In video ads, participants who saw an indication comparison had greater benefit recall than participants who saw dosing or mechanism of action comparisons. In addition, visual depictions of the comparison decreased risk recall for video ads. Overall, the results suggest that comparative claims in DTC ads could mislead consumers about a drug's efficacy and risk; therefore, caution should be used when presenting comparative claims in DTC ads. All rights reserved, Elsevier JF - Social science and medicine AU - Sullivan, Helen W AU - Boudewyns, Vanessa AU - Squire, Claudia AU - Willoughby, Jessica Fitts AU - O' Donoghue, Amie C AU - Williams, Pamela A AD - US Department of Health and Human Services ; RTI International Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1 EP - 11 VL - 120 SN - 0277-9536, 0277-9536 KW - Sociology KW - Communication KW - Marketing KW - Pharmaceuticals KW - Medicine KW - U.S.A. KW - Social sciences KW - Risk theory UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660030777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+science+and+medicine&rft.atitle=Effects+of+comparative+claims+in+prescription+drug+direct-to-consumer+advertising+on+consumer+perceptions+and+recall&rft.au=Sullivan%2C+Helen+W%3BBoudewyns%2C+Vanessa%3BSquire%2C+Claudia%3BWilloughby%2C+Jessica+Fitts%3BO%27+Donoghue%2C+Amie+C%3BWilliams%2C+Pamela+A&rft.aulast=Sullivan&rft.aufirst=Helen&rft.date=2014-11-01&rft.volume=120&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Social+science+and+medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.08.039 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-03-02 N1 - Last updated - 2015-03-03 N1 - SubjectsTermNotLitGenreText - 7738 11245 11239; 2572; 11920; 9474; 11040 11035; 7894; 433 293 14 DO - http://dx.doi.org/10.1016/j.socscimed.2014.08.039 ER - TY - JOUR T1 - Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver AN - 1647008122; 21282352 AB - Tamoxifen is a non-steroidal anti-estrogenic drug widely used for the treatment and prevention of breast cancer in women; however, there is evidence that tamoxifen is hepatocarcinogenic in rats, but not in mice. Additionally, it has been reported that tamoxifen may cause non-alcoholic fatty liver disease (NAFLD) in humans and experimental animals. The goals of the present study were to (i) investigate the mechanisms of the resistance of mice to tamoxifen-induced hepatocarcinogenesis, and (ii) clarify effects of tamoxifen on NAFLD-associated liver injury. Feeding female WSB/EiJ mice a 420p.p.m. tamoxifen-containing diet for 12 weeks resulted in an accumulation of tamoxifen-DNA adducts, (E)- alpha -(deoxyguanosin-N 2-yl)-tamoxifen (dG-TAM) and (E)- alpha -(deoxyguanosin-N 2-yl)-N-desmethyltamoxifen (dG-DesMeTAM), in the livers. The levels of hepatic dG-TAM and dG-DesMeTAM DNA adducts in tamoxifen-treated mice were 578 and 340 adducts/108 nucleotides, respectively, while the extent of global DNA and repetitive elements methylation and histone modifications did not differ from the values in control mice. Additionally, there was no biochemical or histopathological evidence of NAFLD-associated liver injury in mice treated with tamoxifen. A transcriptomic analysis of differentially expressed genes demonstrated that tamoxifen caused predominantly down-regulation of hepatic lipid metabolism genes accompanied by a distinct over-expression of the lipocalin 13 (Lcn13) and peroxisome proliferator receptor gamma (Ppar gamma ), which may prevent the development of NAFLD. The results of the present study demonstrate that the resistance of mice to tamoxifen-induced liver carcinogenesis may be associated with its ability to induce genotoxic alterations only without affecting the cellular epigenome and an inability of tamoxifen to induce the development of NAFLD. JF - Toxicology AU - de Conti, Aline AU - Tryndyak, Volodymyr AU - Churchwell, Mona I AU - Melnyk, Stepan AU - Latendresse, John R AU - Muskhelishvili, Levan AU - Beland, Frederick A AU - Pogribny, Igor P AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 12 EP - 20 PB - Elsevier B.V., P.O. Box 85 Limerick Ireland VL - 325 SN - 0300-483X, 0300-483X KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - NAFLD Non-alcoholic fatty liver disease KW - dG-TAM (E)- alpha -(deoxyguanosin-N 2-yl)-tamoxifen KW - dG-DesMeTAM (E)- alpha -(deoxyguanosin-N 2-yl)-N-desmethyltamoxifen KW - ALT alanine transaminase KW - AST aspartate transaminase KW - LDH lactate dehydrogenase KW - alpha -SMA alpha -smooth muscle actin KW - Col1a1 collagen, type I, alpha 1 KW - Lcn13 lipocalin 13 KW - Ppar gamma peroxisome proliferator receptor gamma KW - Dnmt1 DNA methyltransferase 1 KW - Dnmt3a DNA methyltransferase 3a KW - Dnmt3b DNA methyltransferase 3b KW - SAM S-adenosyl-l-methionine KW - SAH S-adenosyl-l-homocysteine KW - LINE 1 long interspersed elements 1 KW - SINE B1 short interspersed nuclear elements B1 KW - SINE B2 short interspersed nuclear elements B2 KW - H3K4 histone H3 lysine 4 KW - H3K9 histone H3 lysine 9 KW - H3K27 histone H3 lysine 27 KW - H3K79 histone H3 lysine 79 KW - H4K20 histone H4 lysine 20 KW - Gapdh glyceraldehyde-3-phosphate dehydrogenase KW - qRT-PCR quantitative reverse transcription-PCR KW - Tamoxifen KW - Mouse KW - Liver KW - DNA adducts KW - Epigenetics KW - Gene expression KW - Diets KW - Feeding KW - Histones KW - Injuries KW - Peroxisome proliferator-activated receptors KW - Genotoxicity KW - Peroxisomes KW - Nucleotides KW - Lipid metabolism KW - epigenetics KW - Overexpression KW - Carcinogenesis KW - DNA methylation KW - Fatty liver KW - Breast cancer KW - Lipocalin KW - Methylation KW - Repeated DNA sequences KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647008122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Genotoxic%2C+epigenetic%2C+and+transcriptomic+effects+of+tamoxifen+in+mouse+liver&rft.au=de+Conti%2C+Aline%3BTryndyak%2C+Volodymyr%3BChurchwell%2C+Mona+I%3BMelnyk%2C+Stepan%3BLatendresse%2C+John+R%3BMuskhelishvili%2C+Levan%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=de+Conti&rft.aufirst=Aline&rft.date=2014-11-01&rft.volume=325&rft.issue=&rft.spage=12&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=0300483X&rft_id=info:doi/10.1016%2Fj.tox.2014.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Diets; Feeding; DNA adducts; Histones; Peroxisome proliferator-activated receptors; Injuries; Genotoxicity; Tamoxifen; Nucleotides; Peroxisomes; Lipid metabolism; epigenetics; Overexpression; Carcinogenesis; DNA methylation; Breast cancer; Fatty liver; Lipocalin; Methylation; Repeated DNA sequences DO - http://dx.doi.org/10.1016/j.tox.2014.08.004 ER - TY - JOUR T1 - Sex-specific dose-response analysis of genotoxicity in cyproterone acetate-treated F344 rats AN - 1647005565; 21285849 AB - Cyproterone acetate (CPA), a synthetic hormonal drug, induces rat liver tumors in a sex-specific manner, with five-fold higher doses needed to induce liver tumors in male rats compared to females. In order to evaluate the potential of the in vivo alkaline Comet assay to predict the sex-specific carcinogenicity of CPA, CPA-induced direct DNA damage (DNA strand breaks and alkali-labile sites) were evaluated in the livers of both male and female F344 rats. In addition, secondary oxidative DNA damage was measured concurrently utilizing the human 8-oxoguanine-DNA-N-glycosylase (hOGG1) and EndonucleaseIII (EndoIII)-modified in vivo alkaline Comet assays and the reticulocyte micronucleus (MN) frequency was analyzed in peripheral blood. Groups of 5 seven-week-old male and female F344 rats received olive oil or 10, 25, 50 or 100mg/kg bw CPA in olive oil by gavage at 0, 24, and 45h and were sacrificed at 48h. CPA-induced direct DNA damage in rat liver showed the same sex-specific pattern as its hepatotumorigenicity: a five-fold-higher dose of CPA was needed to induce a statistically significant increase in direct DNA damage in livers of males compared to females. However, peripheral blood MN frequency was weak in both sexes and CPA-induced oxidative DNA damage was generally greater in male than female rat livers. Taken together, our results demonstrate concordance in the sex-specificity of CPA in the in vivo alkaline Comet assay and cancer bioassay, while the induction of oxidative DNA damage by CPA was not directly correlated with its tumorigenicity. JF - Mutation Research/Genetic Toxicology and Environmental Mutagenesis AU - Ding, Wei AU - Bishop, Michelle E AU - Pearce, Mason G AU - Davis, Kelly J AU - White, Gene A AU - Lyn-Cook, Lascelles E AU - Manjanatha, Mugimane G AD - Division of Genetic and Molecular Toxicology, US FDA/National Center for Toxicological Research, Jefferson, AR 72079, United States Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1 EP - 7 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 774 SN - 1383-5718, 1383-5718 KW - Genetics Abstracts; Toxicology Abstracts KW - CPA cyproterone acetate KW - COC combined oral contraceptive KW - VTE venous thromboembolism KW - hOGG1 human 8-oxoguanine DNA N-glycosylase 1 KW - EndoIII endonuclease-III KW - ROS reactive oxygen species KW - LOEL lowest observable effect level KW - MN micronucleus KW - bw by weight KW - Cyproterone acetate (CPA) KW - In vivo Comet assay KW - Liver KW - DNA damage KW - Oxidative DNA damage KW - Sex-specific genotoxicity KW - Genotoxicity KW - Statistical analysis KW - Tumorigenicity KW - Peripheral blood KW - Tumors KW - Sex differences KW - Olive oil KW - Acetic acid KW - Cancer KW - Mutagenesis KW - Cyproterone acetate KW - Carcinogenicity KW - Comet assay KW - Drugs KW - Manganese KW - Reticulocytes KW - Sex KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647005565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Sex-specific+dose-response+analysis+of+genotoxicity+in+cyproterone+acetate-treated+F344+rats&rft.au=Ding%2C+Wei%3BBishop%2C+Michelle+E%3BPearce%2C+Mason+G%3BDavis%2C+Kelly+J%3BWhite%2C+Gene+A%3BLyn-Cook%2C+Lascelles+E%3BManjanatha%2C+Mugimane+G&rft.aulast=Ding&rft.aufirst=Wei&rft.date=2014-11-01&rft.volume=774&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+Research%2FGenetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2014.08.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Genotoxicity; Statistical analysis; Tumorigenicity; Peripheral blood; Tumors; Olive oil; Sex differences; Acetic acid; Cancer; Mutagenesis; DNA damage; Cyproterone acetate; Carcinogenicity; Liver; Comet assay; Reticulocytes; Manganese; Drugs; Sex DO - http://dx.doi.org/10.1016/j.mrgentox.2014.08.005 ER - TY - JOUR T1 - Differential effects of triclosan on the activation of mouse and human peroxisome proliferator-activated receptor alpha AN - 1647003672; 21286153 AB - Triclosan is an anti-bacterial agent used in many personal care products, household items, medical devices, and clinical settings. Liver tumors occur in mice exposed to triclosan, a response attributed to peroxisome proliferator-activated receptor alpha (PPAR alpha ) activation; however, the effects of triclosan on mouse and human PPAR alpha have not been fully evaluated. We compared the effects of triclosan on mouse and human PPAR alpha using PPAR alpha reporter assays and on downstream events of PPAR alpha activation using mouse hepatoma Hepa1c1c7 cells and human hepatoma HepG2 cells. PPAR alpha transcriptional activity was increased by triclosan in a mouse PPAR alpha reporter assay and decreased in a human PPAR alpha reporter assay. Concentrations of triclosan inhibiting 50% cell growth were similar in both human and mouse hepatoma cells. Western blotting analysis showed that triclosan increased acyl-coenzyme A oxidase (ACOX1), a PPAR alpha target, in Hepa1c1c7 cells but decreased the level in HepG2 cells. Treatment of Hepa1c1c7 cells with triclosan enhanced DNA synthesis and suppressed transforming growth factor beta-mediated apoptosis. This did not occur in HepG2 cells. These data demonstrate that triclosan had similar cytotoxicity in Hepa1c1c7 and HepG2 cells, but differential effects on the activation of PPAR alpha , the expression of ACOX1, and downstream events including DNA synthesis and apoptosis. JF - Toxicology Letters AU - Wu, Yuanfeng AU - Wu, Qiangen AU - Beland, Frederick A AU - Ge, Peter AU - Manjanatha, Mugimane G AU - Fang, Jia-Long AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, HFT-110, Jefferson, AR 72079, USA Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 17 EP - 28 PB - Elsevier B.V., Elsevier House, Brookvale Plaza East Park Shannon, Co. Clare Ireland VL - 231 IS - 1 SN - 0378-4274, 0378-4274 KW - Toxicology Abstracts KW - Triclosan KW - PPAR alpha KW - DNA synthesis KW - Apoptosis KW - Hepatoma KW - DNA biosynthesis KW - Western blotting KW - Cytotoxicity KW - Data processing KW - Peroxisome proliferator-activated receptors KW - Liver KW - Transcription KW - Tumors KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647003672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Letters&rft.atitle=Differential+effects+of+triclosan+on+the+activation+of+mouse+and+human+peroxisome+proliferator-activated+receptor+alpha&rft.au=Wu%2C+Yuanfeng%3BWu%2C+Qiangen%3BBeland%2C+Frederick+A%3BGe%2C+Peter%3BManjanatha%2C+Mugimane+G%3BFang%2C+Jia-Long&rft.aulast=Wu&rft.aufirst=Yuanfeng&rft.date=2014-11-01&rft.volume=231&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Toxicology+Letters&rft.issn=03784274&rft_id=info:doi/10.1016%2Fj.toxlet.2014.09.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Western blotting; DNA biosynthesis; Hepatoma; Cytotoxicity; Data processing; Apoptosis; Peroxisome proliferator-activated receptors; Liver; Transcription; Tumors; Triclosan DO - http://dx.doi.org/10.1016/j.toxlet.2014.09.001 ER - TY - JOUR T1 - Optimizing dosing of oncology drugs. AN - 1635012184; 25105705 AB - The purpose of this article is to acknowledge the challenges in optimizing the dosing of oncology drugs and to propose potential approaches to address these challenges in order to optimize effectiveness, minimize toxicity, and promote adherence in patients. These approaches could provide better opportunities to understand the sources of variability in drug exposure and clinical outcomes during the development and premarketing evaluation of investigational new drugs. JF - Clinical pharmacology and therapeutics AU - Minasian, L AU - Rosen, O AU - Auclair, D AU - Rahman, A AU - Pazdur, R AU - Schilsky, R L AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland, USA. ; Millennium: The Takeda Oncology Company, Cambridge, Massachusetts, USA. ; Multiple Myeloma Research Foundation, Norwalk, Connecticut, USA. ; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. ; American Society of Clinical Oncology, Alexandria, Virginia, USA. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 572 EP - 579 VL - 96 IS - 5 KW - Antineoplastic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Medication Adherence KW - Dose-Response Relationship, Drug KW - Humans KW - Time Factors KW - Antineoplastic Agents -- administration & dosage KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1635012184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Optimizing+dosing+of+oncology+drugs.&rft.au=Minasian%2C+L%3BRosen%2C+O%3BAuclair%2C+D%3BRahman%2C+A%3BPazdur%2C+R%3BSchilsky%2C+R+L&rft.aulast=Minasian&rft.aufirst=L&rft.date=2014-11-01&rft.volume=96&rft.issue=5&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2014.153 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-23 N1 - Date created - 2014-10-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/clpt.2014.153 ER - TY - RPRT T1 - FOREWORD AN - 1629597454 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629597454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-11-01&rft.volume=&rft.issue=588&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2014 N1 - Last updated - 2015-03-21 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF GLYCIDAMIDE (CAS NO. 5694-00-8) IN F344/N Nctr RATS AND B6C3F1/Nctr MICE (DRINKING WATER STUDIES) AN - 1629597310 AB - Glycidamide is a reactive electrophile that occurs primarily as a metabolite of acrylamide. Because acrylamide can be formed as a by-product during the cooking of starchy foods and the roasting of coffee, the National Toxicology Program performed simultaneous studies to determine and compare the long-term effects of actylamide and glycidamide in male and female rats and mice. Results revealed that animals receiving 0.70 mM glycidamide had lower survival rates than the controls. The rates of several types of cancer increased in each of the animal studies. Glycidamide in the drinking water caused cancer in several different tissues in male and female rats and mice. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 1 EP - 15,17-35,37-101,103-125,127-163,165-183,185-189,191-205,207-209,211-213,215-217,219-275 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Cancer KW - Rodents KW - Chemical compounds KW - Toxicology KW - Toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629597310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+GLYCIDAMIDE+%28CAS+NO.+5694-00-8%29+IN+F344%2FN+Nctr+RATS+AND+B6C3F1%2FNctr+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-11-01&rft.volume=&rft.issue=588&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2014 N1 - Document feature - Illustrations; Tables; Graphs; References N1 - Last updated - 2015-03-21 ER - TY - RPRT T1 - Table of contents AN - 1629597290 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1629597290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-11-01&rft.volume=&rft.issue=588&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Nov 2014 N1 - Last updated - 2015-03-21 ER - TY - JOUR T1 - Development of a microchip Europium nanoparticle immunoassay for sensitive point-of-care HIV detection AN - 1627954298; 20952177 AB - Rapid, sensitive and specific diagnostic assays play an indispensable role in determination of HIV infection stages and evaluation of efficacy of antiretroviral therapy. Recently, our laboratory developed a sensitive Europium nanoparticle-based microtiter-plate immunoassay capable of detecting target analytes at subpicogram per milliliter levels without the use of catalytic enzymes and signal amplification processes. Encouraged by its sensitivity and simplicity, we continued to miniaturize this assay to a microchip platform for the purpose of converting the benchtop assay technique to a point-of-care test. It was found that detection capability of the microchip platform could be readily improved using Europium nanoparticle probes. We were able to routinely detect 5pg/mL (4.6 attomoles) of HIV-1 p24 antigen at a signal-to-blank ratio of 1.5, a sensitivity level reasonably close to that of microtiter-plate Europium nanoparticle assay. Meanwhile, use of the microchip platform effectively reduced sample/reagent consumption 4.5 fold and shortened total assay time 2 fold in comparison with microtiter plate assays. Complex matrix substance in plasma negatively affected the microchip assays and the effects could be minimized by diluting the samples before loading. With further improvements in sensitivity, reproducibility, usability, assay process simplification, and incorporation of portable time-resolved fluorescence reader, Europium nanoparticle immunoassay technology could be adapted to meet the challenges of point-of-care diagnosis of HIV or other health-threatening pathogens at bedside or in resource-limited settings. JF - Biosensors and Bioelectronics AU - Liu, Jikun AU - Du, Bingchen AU - Zhang, Panhe AU - Haleyurgirisetty, Mohan AU - Zhao, Jiangqin AU - Ragupathy, Viswanath AU - Lee, Sherwin AU - DeVoe, Don L AU - Hewlett, Indira K AD - Laboratory of Molecular Virology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892, USA Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 177 EP - 183 PB - Elsevier B.V., 660 White Plains Rd. Tarrytown NY 10591-5153 United States VL - 61 SN - 0956-5663, 0956-5663 KW - Biotechnology and Bioengineering Abstracts KW - Europium nanoparticles KW - Microchip KW - Point-of-care diagnostics KW - HIV KW - Resource-limited settings KW - p24 protein KW - Fluorescence KW - antiretroviral therapy KW - Probes KW - Enzymes KW - Pathogens KW - Infection KW - Biosensors KW - Human immunodeficiency virus 1 KW - microchips KW - nanoparticles KW - Immunoassays KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627954298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+and+Bioelectronics&rft.atitle=Development+of+a+microchip+Europium+nanoparticle+immunoassay+for+sensitive+point-of-care+HIV+detection&rft.au=Liu%2C+Jikun%3BDu%2C+Bingchen%3BZhang%2C+Panhe%3BHaleyurgirisetty%2C+Mohan%3BZhao%2C+Jiangqin%3BRagupathy%2C+Viswanath%3BLee%2C+Sherwin%3BDeVoe%2C+Don+L%3BHewlett%2C+Indira+K&rft.aulast=Liu&rft.aufirst=Jikun&rft.date=2014-11-01&rft.volume=61&rft.issue=&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Biosensors+and+Bioelectronics&rft.issn=09565663&rft_id=info:doi/10.1016%2Fj.bios.2014.04.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Biosensors; p24 protein; Fluorescence; antiretroviral therapy; microchips; Probes; Enzymes; Pathogens; Infection; Immunoassays; nanoparticles; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.bios.2014.04.057 ER - TY - GEN T1 - Human and animal evidence supports lower occupational exposure limits for poorly-soluble respirable particles: Letter to the Editor re: 'Low-toxicity dusts: Current exposure guidelines are not sufficiently protective' by Cherrie, Brosseau, Hay and Donaldson. AN - 1624934076; 25193937 JF - The Annals of occupational hygiene AU - Kuempel, Eileen D AU - Attfield, Michael D AU - Stayner, Leslie T AU - Castranova, Vincent Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1205 EP - 1208 VL - 58 IS - 9 KW - Dust KW - 0 KW - Index Medicus KW - Humans KW - Guidelines as Topic -- standards KW - Dust -- analysis KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1624934076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Annals+of+occupational+hygiene&rft.atitle=Human+and+animal+evidence+supports+lower+occupational+exposure+limits+for+poorly-soluble+respirable+particles%3A+Letter+to+the+Editor+re%3A+%27Low-toxicity+dusts%3A+Current+exposure+guidelines+are+not+sufficiently+protective%27+by+Cherrie%2C+Brosseau%2C+Hay+and+Donaldson.&rft.au=Kuempel%2C+Eileen+D%3BAttfield%2C+Michael+D%3BStayner%2C+Leslie+T%3BCastranova%2C+Vincent&rft.aulast=Kuempel&rft.aufirst=Eileen&rft.date=2014-11-01&rft.volume=58&rft.issue=9&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+occupational+hygiene&rft.issn=1475-3162&rft_id=info:doi/10.1093%2Fannhyg%2Fmeu058 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-23 N1 - Date created - 2014-11-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Environ Health Perspect. 1997 Sep;105 Suppl 5:1337-46 [9400748] Toxicol Sci. 2005 Dec;88(2):614-29 [16177241] Toxicol Pathol. 2007 Jan;35(1):136-47 [17325982] Inhal Toxicol. 2007;19 Suppl 1:189-98 [17886067] Am J Ind Med. 2008 Apr;51(4):231-45 [18247381] Occup Environ Med. 2010 Apr;67(4):270-6 [19819863] J Radiol Prot. 2010 Sep;30(3):491-512 [20826887] Radiat Prot Dosimetry. 2011 Mar;144(1-4):353-6 [21036808] Occup Environ Med. 2011 Dec;68(12):908-13 [21597107] Ann Occup Hyg. 2013 Jul;57(6):685-91 [23835898] Occup Environ Med. 2014 Jan;71(1):30-9 [24186945] Fundam Appl Toxicol. 1997 May;37(1):37-53 [9193921] Inhal Toxicol. 1999 Dec;11(12):1059-76 [10562697] Drug Chem Toxicol. 2000 Feb;23(1):203-22 [10711398] Inhal Toxicol. 2000 Jan-Feb;12(1-2):1-17 [10715616] Inhal Toxicol. 2000 Dec;12(12):1113-26 [11114784] Regul Toxicol Pharmacol. 2001 Aug;34(1):69-87 [11502158] Regul Toxicol Pharmacol. 2001 Aug;34(1):88-101 [11502159] Toxicol Sci. 2002 Nov;70(1):86-97 [12388838] Toxicol Sci. 2004 Feb;77(2):347-57 [14600271] Toxicol Pathol. 2004 Mar-Apr;32 Suppl 1:40-8 [15209402] Fundam Appl Toxicol. 1988 Apr;10(3):369-84 [3286345] Crit Rev Toxicol. 1989;20(3):175-211 [2692607] Fundam Appl Toxicol. 1991 Aug;17(2):300-13 [1662649] Exp Lung Res. 1992 Jan-Mar;18(1):87-104 [1572327] Am J Ind Med. 1995 Jan;27(1):137-51 [7900731] Fundam Appl Toxicol. 1995 Nov;28(1):41-50 [8566482] Comment On: Ann Occup Hyg. 2013 Jul;57(6):685-91 [23835898] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/annhyg/meu058 ER - TY - JOUR T1 - A shared regulatory perspective on deferral from blood donation of men who have sex with men (MSM) AN - 1622617344; 20869712 AB - National Regulatory Authorities (NRAs) establish deferral criteria for donors with risk factors for transfusion transmissible infections (TTI). In most jurisdictions, epidemiological data show that men who have sex with men (MSM) have a significantly higher rate of TTI than the general population. Nevertheless, changes from an indefinite donor deferral for MSM have been considered in many countries in response to concerns over a perceived discrimination and questioning of the scientific need. Changes to MSM donor deferral criteria should be based on sound scientific evidence. Safety of transfusion recipients should be the first priority, and stakeholder input should be sought. JF - Vox Sanguinis AU - Epstein, J AU - Ganz, PR AU - Seitz, R AU - Jutzi, M AU - Schaerer, C AU - Michaud, G AU - Agbanyo, F AU - Smith, G AU - Prosser, I AU - Heiden, M AU - Saint-Marie, I AU - Oualikene-Gonin, W AU - Hamaguchi, I AU - Yasuda, N AD - Office of Blood Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 416 EP - 419 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 107 IS - 4 SN - 0042-9007, 0042-9007 KW - Risk Abstracts KW - Stakeholders KW - Blood donors KW - Perception KW - Risk factors KW - Jurisdiction KW - Safety KW - Discrimination KW - Priorities KW - Homosexuality KW - Transfusion KW - Infection KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622617344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vox+Sanguinis&rft.atitle=A+shared+regulatory+perspective+on+deferral+from+blood+donation+of+men+who+have+sex+with+men+%28MSM%29&rft.au=Epstein%2C+J%3BGanz%2C+PR%3BSeitz%2C+R%3BJutzi%2C+M%3BSchaerer%2C+C%3BMichaud%2C+G%3BAgbanyo%2C+F%3BSmith%2C+G%3BProsser%2C+I%3BHeiden%2C+M%3BSaint-Marie%2C+I%3BOualikene-Gonin%2C+W%3BHamaguchi%2C+I%3BYasuda%2C+N&rft.aulast=Epstein&rft.aufirst=J&rft.date=2014-11-01&rft.volume=107&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Vox+Sanguinis&rft.issn=00429007&rft_id=info:doi/10.1111%2Fvox.12166 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2014-11-26 N1 - SubjectsTermNotLitGenreText - Blood donors; Stakeholders; Perception; Risk factors; Safety; Jurisdiction; Priorities; Discrimination; Homosexuality; Infection; Transfusion DO - http://dx.doi.org/10.1111/vox.12166 ER - TY - JOUR T1 - The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance AN - 1622601249; 20869475 AB - The biopharmaceutics risk assessment roadmap (BioRAM) optimizes drug product development and performance by using therapy-driven target drug delivery profiles as a framework to achieve the desired therapeutic outcome. Hence, clinical relevance is directly built into early formulation development. Biopharmaceutics tools are used to identify and address potential challenges to optimize the drug product for patient benefit. For illustration, BioRAM is applied to four relatively common therapy-driven drug delivery scenarios: rapid therapeutic onset, multiphasic delivery, delayed therapeutic onset, and maintenance of target exposure. BioRAM considers the therapeutic target with the drug substance characteristics and enables collection of critical knowledge for development of a dosage form that can perform consistently for meeting the patient's needs. Accordingly, the key factors are identified and in vitro, in vivo, and in silico modeling and simulation techniques are used to elucidate the optimal drug delivery rate and pattern. BioRAM enables (1) feasibility assessment for the dosage form, (2) development and conduct of appropriate "learning and confirming" studies, (3) transparency in decision-making, (4) assurance of drug product quality during lifecycle management, and (5) development of robust linkages between the desired clinical outcome and the necessary product quality attributes for inclusion in the quality target product profile. copyright 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3377-3397, 2014 JF - Journal of Pharmaceutical Sciences AU - Selen, Arzu AU - Dickinson, Paul A AU - Muellertz, Anette AU - Crison, John R AU - Mistry, Hitesh B AU - Cruanes, Maria T AU - Martinez, Marilyn N AU - Lennernaes, Hans AU - Wigal, Tim L AU - Swinney, David C AU - Polli, James E AU - Serajuddin, Abu TM AU - Cook, Jack A AU - Dressman, Jennifer B AD - Office of New Drug Quality Assessment, US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland. Y1 - 2014/11// PY - 2014 DA - Nov 2014 SP - 3377 EP - 3397 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 103 IS - 11 SN - 0022-3549, 0022-3549 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Drug delivery KW - Decision making KW - Learning KW - Drug development KW - Development KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622601249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=The+Biopharmaceutics+Risk+Assessment+Roadmap+for+Optimizing+Clinical+Drug+Product+Performance&rft.au=Selen%2C+Arzu%3BDickinson%2C+Paul+A%3BMuellertz%2C+Anette%3BCrison%2C+John+R%3BMistry%2C+Hitesh+B%3BCruanes%2C+Maria+T%3BMartinez%2C+Marilyn+N%3BLennernaes%2C+Hans%3BWigal%2C+Tim+L%3BSwinney%2C+David+C%3BPolli%2C+James+E%3BSerajuddin%2C+Abu+TM%3BCook%2C+Jack+A%3BDressman%2C+Jennifer+B&rft.aulast=Selen&rft.aufirst=Arzu&rft.date=2014-11-01&rft.volume=103&rft.issue=11&rft.spage=3377&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.24162 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2014-11-12 N1 - SubjectsTermNotLitGenreText - Risk assessment; Decision making; Drug delivery; Learning; Drug development; Development DO - http://dx.doi.org/10.1002/jps.24162 ER - TY - JOUR T1 - Evolution of the Food and Drug Administration approach to liver safety assessment for new drugs: current status and challenges. AN - 1618826722; 25352324 AB - Prompted by approval in 1997 of troglitazone and bromfenac, two drugs that promptly began to show serious and sometimes fatal liver toxicity, we began at the Food and Drug Administration (FDA) a series of annual conferences in 1999 to consider issues of drug-induced liver injury (DILI). First inviting reviewers of new drug applications we opened the audiences in 2001 to pharmaceutical industry and academic consultants to industry and FDA, and slides shown at the meetings were posted on the internet to be available at the website of the American Association for the Study of Liver Diseases (AASLD)-go to ( http://www.aasld.org/dili/Pages/default.aspx ). Observations by Dr. Hyman J. Zimmerman that "drug-induced hepatocellular jaundice is a serious lesion" with possible mortality formed a basis for developing a computer program to plot peak serum values for alanine aminotransferase (ALT) and total bilirubin (TBL) in an x-y log-log graph for all subjects enrolled in clinical trials. This program had the capability to show the time course of all liver tests for individuals who had both hepatocellular injury and reduced whole liver function, plus clinical narratives to diagnose the severity and most likely cause of the abnormalities. We called the program eDISH (for evaluation of Drug-Induced Serious Hepatotoxicity), and began in 2004 to use it to assess DILI in clinical trial subjects. From 2008, comments made by the presenters at the conferences about their slides and ensuing discussions have been added to the website. All this has raised awareness of the problem, and since 1997, the FDA has not had to withdraw a single drug because of post-marketing hepatotoxicity. Many issues still remain to be resolved; among the most controversial is the best method to estimate likelihood that a given liver injury was actually caused by the drug in question. On November 9, 2012, a workshop was convened to discuss the best practices for the assessment of drug-induced liver injury (DILI) in clinical trials. JF - Drug safety AU - Senior, John R AD - Office of Pharmacovigilance and Epidemiology, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993-0002, USA, john.senior@fda.hhs.gov. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - S9 EP - 17 VL - 37 Suppl 1 KW - Index Medicus KW - United States KW - Animals KW - United States Food and Drug Administration KW - Humans KW - Drug-Related Side Effects and Adverse Reactions -- diagnosis KW - Safety-Based Drug Withdrawals -- statistics & numerical data KW - Chemical and Drug Induced Liver Injury -- prevention & control KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Diagnosis, Computer-Assisted KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1618826722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+safety&rft.atitle=Evolution+of+the+Food+and+Drug+Administration+approach+to+liver+safety+assessment+for+new+drugs%3A+current+status+and+challenges.&rft.au=Senior%2C+John+R&rft.aulast=Senior&rft.aufirst=John&rft.date=2014-11-01&rft.volume=37+Suppl+1&rft.issue=&rft.spage=S9&rft.isbn=&rft.btitle=&rft.title=Drug+safety&rft.issn=1179-1942&rft_id=info:doi/10.1007%2Fs40264-014-0182-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-29 N1 - Date created - 2014-10-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: N Engl J Med. 2000 Feb 3;342(5):359-60 [10660405] Am J Health Syst Pharm. 2000 May 1;57(9):834 [10840515] JAMA. 1999 May 12;281(18):1728-34 [10328074] Am J Gastroenterol. 1999 May;94(5):1393-6 [10235225] Ann Hepatol. 2014 Mar-Apr;13(2):248-55 [24552867] Hepatology. 2014 Feb;59(2):661-70 [24037963] Clin Mol Hepatol. 2013 Jun;19(2):105-15 [23837134] Clin Pharmacol Ther. 2012 Sep;92(3):332-9 [22871997] Pharmacoepidemiol Drug Saf. 2011 Jul;20(7):772-7 [21574210] Drug Saf. 2011 Mar 1;34(3):243-52 [21332248] Hepatology. 2010 Jun;51(6):2117-26 [20512999] Ann Intern Med. 1959 Dec;51:1230-52 [14434187] Science. 1959 Jul 3;130(3366):9-21 [13668531] Mayo Clin Health Lett. 1998 Nov;16(11):4 [9809019] N Engl J Med. 1998 Mar 26;338(13):916-7 [9518284] BMJ. 1997 Dec 13;315(7122):1564 [9437272] Am J Health Syst Pharm. 1997 Oct 1;54(19):2151-2 [9331432] Cleve Clin J Med. 1997 May;64(5):238-40 [9149473] J Clin Epidemiol. 1993 Nov;46(11):1331-6 [8229111] J Clin Epidemiol. 1993 Nov;46(11):1323-30 [8229110] Hepatology. 1989 Jul;10(1):1-7 [2737595] Perspect Biol Med. 1968 Autumn;12(1):135-61 [4387099] N Engl J Med. 1966 May 26;274(21):1171-3 [5934954] Hepatology. 2004 Feb;39(2):574-8 [14768020] Drug Saf. 2002;25(6):381-92 [12071774] Clin Infect Dis. 2000 Feb;30(2):400-1 [10671353] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s40264-014-0182-7 ER - TY - JOUR T1 - Comparison of blood volatile organic compound levels in residents of Calcasieu and Lafayette Parishes, LA, with US reference ranges. AN - 1615742664; 24472757 AB - Agency for Toxic Substances and Disease Registry conducted a study to evaluate body burden levels of volatile organic compounds (VOCs) among residents of highly industrialized Calcasieu Parish, LA, USA, in 2002. Blood VOC levels in a representative sample of participants in Calcasieu Parish were compared with a similar group of participants in the less-industrialized Lafayette Parish. Participants' ages ranged from 15 to 91 years, 46% were men, and 89% were Caucasian. VOC levels in these two populations were also compared at the national levels. Solid-phase microextraction coupled with gas chromatography mass spectrometry was used to measure levels of 30 VOCs in blood samples collected from 283 self-described non-smoking study participants. Of the 30 VOCs, 6 had quantifiable levels in at least 25% of the blood samples analyzed. The frequency of detection was >95% for benzene and m-/p-xylene, >60% for 1,4-dichlorbenzene and toluene, 27% for ethylbenzene, and 39% for styrene. Calcasieu and Lafayette Parish participants had similar distributions for six VOCs in key percentiles and geometric means. When compared with a representative sampling of the 1999-2000 US general population, no significant differences were found between the parish data and the US general population. JF - Journal of exposure science & environmental epidemiology AU - Uddin, Mohammed S AU - Blount, Benjamin C AU - Lewin, Michael D AU - Potula, Vijayalakshmi AU - Ragin, Angela D AU - Dearwent, Steve M AD - Division of Toxicology and Human Health Sciences, Agency for Toxic Substances and Disease Registry, Centers for Disease Control and Prevention, Atlanta, GA, USA. ; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. ; Office of the Director, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Atlanta, GA, USA. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 602 EP - 607 VL - 24 IS - 6 KW - Air Pollutants KW - 0 KW - Volatile Organic Compounds KW - Index Medicus KW - United States KW - Young Adult KW - Reference Values KW - Air Pollution -- analysis KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - Aged KW - Smoking -- epidemiology KW - Aged, 80 and over KW - Logistic Models KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Middle Aged KW - Adolescent KW - Male KW - Environmental Monitoring -- methods KW - Female KW - Louisiana -- epidemiology KW - Industry KW - Volatile Organic Compounds -- classification KW - Air Pollutants -- blood KW - Volatile Organic Compounds -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1615742664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+exposure+science+%26+environmental+epidemiology&rft.atitle=Comparison+of+blood+volatile+organic+compound+levels+in+residents+of+Calcasieu+and+Lafayette+Parishes%2C+LA%2C+with+US+reference+ranges.&rft.au=Uddin%2C+Mohammed+S%3BBlount%2C+Benjamin+C%3BLewin%2C+Michael+D%3BPotula%2C+Vijayalakshmi%3BRagin%2C+Angela+D%3BDearwent%2C+Steve+M&rft.aulast=Uddin&rft.aufirst=Mohammed&rft.date=2014-11-01&rft.volume=24&rft.issue=6&rft.spage=602&rft.isbn=&rft.btitle=&rft.title=Journal+of+exposure+science+%26+environmental+epidemiology&rft.issn=1559-064X&rft_id=info:doi/10.1038%2Fjes.2013.94 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-22 N1 - Date created - 2014-10-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/jes.2013.94 ER - TY - JOUR T1 - Application of systems pharmacology to explore mechanisms of hepatotoxicity. AN - 1615740425; 25336266 AB - Advances in systems biology have allowed the development of a highly characterized systems pharmacology model to study mechanisms of drug-induced hepatotoxicity. In this issue of CPT, Yang et al. describe a model, DILIsym, used to characterize mechanisms of hepatotoxicity of troglitazone. Their modeling approach has provided new insight into troglitazone-induced hepatotoxicity in humans but is not associated with hepatotoxicity in rats, consistent with preclinical data for this drug. JF - Clinical pharmacology and therapeutics AU - Shon, J AU - Abernethy, D R AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 536 EP - 537 VL - 96 IS - 5 KW - Bile Acids and Salts KW - 0 KW - Chromans KW - Hypoglycemic Agents KW - Thiazolidinediones KW - troglitazone KW - I66ZZ0ZN0E KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Humans KW - Male KW - Chromans -- toxicity KW - Chemical and Drug Induced Liver Injury -- etiology KW - Hypoglycemic Agents -- toxicity KW - Thiazolidinediones -- toxicity KW - Bile Acids and Salts -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1615740425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Application+of+systems+pharmacology+to+explore+mechanisms+of+hepatotoxicity.&rft.au=Shon%2C+J%3BAbernethy%2C+D+R&rft.aulast=Shon&rft.aufirst=J&rft.date=2014-11-01&rft.volume=96&rft.issue=5&rft.spage=536&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2014.167 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-23 N1 - Date created - 2014-10-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment On: Clin Pharmacol Ther. 2014 Nov;96(5):589-98 [25068506] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/clpt.2014.167 ER - TY - JOUR T1 - Correlation between CYP1A1 transcript, protein level, enzyme activity and DNA adduct formation in normal human mammary epithelial cell strains exposed to benzo[a]pyrene. AN - 1614694870; 25245543 AB - The polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene (BP) is thought to bind covalently to DNA, through metabolism by cytochrome P450 1A1 (CYP1A1) and CYP1B1, and other enzymes, to form r7, t8, t9-trihydroxy-c-10-(N(2)-deoxyguanosyl)-7,8,9,10-tetrahydro-benzo[a]-pyrene (BPdG). Evaluation of RNA expression data, to understand the contribution of different metabolic enzymes to BPdG formation, is typically presented as fold-change observed upon BP exposure, leaving the actual number of RNA transcripts unknown. Here, we have quantified RNA copies/ng cDNA (RNA cpn) for CYP1A1 and CYP1B1, as well as quinone oxidoreductase 1 (NQO1), which may reduce formation of BPdG adducts, using primary normal human mammary epithelial cell (NHMEC) strains, and the MCF-7 breast cancer cell line. In unexposed NHMECs, basal RNA cpn values were 58-836 for CYP1A1, 336-5587 for CYP1B1 and 5943-40112 for NQO1. In cells exposed to 4.0 µM BP for 12h, RNA cpn values were 251-13234 for CYP1A1, 4133-57078 for CYP1B1 and 4456-55887 for NQO1. There were 3.5 (mean, range 0.2-15.8) BPdG adducts/10(8) nucleotides in the NHMECs (n = 16), and 790 in the MCF-7s. In the NHMECs, BP-induced CYP1A1 RNA cpn was highly associated with BPdG (P = 0.002), but CYP1B1 and NQO1 were not. Western blots of four NHMEC strains, chosen for different levels of BPdG adducts, showed a linear correlation between BPdG and CYP1A1, but not CYP1B1 or NQO1. Ethoxyresorufin-O-deethylase (EROD) activity, which measures CYP1A1 and CYP1B1 together, correlated with BPdG, but NQO1 activity did not. Despite more numerous levels of CYP1B1 and NQO1 RNA cpn in unexposed and BP-exposed NHMECs and MCF-7cells, BPdG formation was only correlated with induction of CYP1A1 RNA cpn. The higher level of BPdG in MCF-7 cells, compared to NHMECs, may have been due to a much increased induction of CYP1A1 and EROD. Overall, BPdG correlation was observed with CYP1A1 protein and CYP1A1/1B1 enzyme activity, but not with CYP1B1 or NQO1 protein, or NQO1 enzyme activity. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society 2014. JF - Mutagenesis AU - Divi, Rao L AU - Lindeman, Tracey L Einem AU - Shockley, Marie E AU - Keshava, Channa AU - Weston, Ainsley AU - Poirier, Miriam C AD - Carcinogen-DNA Interactions Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20817, USA, National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA and Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. ; National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA and. ; Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. ; Carcinogen-DNA Interactions Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20817, USA, National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA and Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA. poirierm@exchange.nih.gov. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 409 EP - 417 VL - 29 IS - 6 KW - DNA Adducts KW - 0 KW - RNA, Messenger KW - Benzo(a)pyrene KW - 3417WMA06D KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Cytochrome P-450 CYP1B1 KW - NAD(P)H Dehydrogenase (Quinone) KW - EC 1.6.5.2 KW - NQO1 protein, human KW - Index Medicus KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Cytochrome P-450 CYP1B1 -- metabolism KW - Humans KW - MCF-7 Cells KW - NAD(P)H Dehydrogenase (Quinone) -- metabolism KW - RNA, Messenger -- genetics KW - Epithelial Cells -- metabolism KW - Mammary Glands, Human -- cytology KW - Cytochrome P-450 CYP1A1 -- genetics KW - Epithelial Cells -- drug effects KW - Benzo(a)pyrene -- toxicity KW - Cytochrome P-450 CYP1A1 -- metabolism KW - DNA Adducts -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1614694870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Correlation+between+CYP1A1+transcript%2C+protein+level%2C+enzyme+activity+and+DNA+adduct+formation+in+normal+human+mammary+epithelial+cell+strains+exposed+to+benzo%5Ba%5Dpyrene.&rft.au=Divi%2C+Rao+L%3BLindeman%2C+Tracey+L+Einem%3BShockley%2C+Marie+E%3BKeshava%2C+Channa%3BWeston%2C+Ainsley%3BPoirier%2C+Miriam+C&rft.aulast=Divi&rft.aufirst=Rao&rft.date=2014-11-01&rft.volume=29&rft.issue=6&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgeu049 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-18 N1 - Date created - 2014-10-20 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Carcinogenesis. 2000 Jul;21(7):1281-9 [10874004] Discov Med. 2012 Oct;14(77):283-8 [23114584] Cancer Res. 2001 Dec 1;61(23):8465-9 [11731429] Environ Mol Mutagen. 2002;39(2-3):201-7 [11921190] Carcinogenesis. 2002 Dec;23(12):2043-9 [12507927] Methods Enzymol. 2004;382:115-44 [15047100] Nature. 1974 Nov 22;252(5481):326-8 [4473724] In Vitro. 1980 May;16(5):415-25 [6993343] Br J Cancer. 1981 Jul;44(1):24-34 [6789855] Nature. 1983 Jun 9-15;303(5917):468-72 [6304528] Prog Clin Biol Res. 1989;298:3-15 [2501799] Nucleic Acids Res. 1991 Aug 11;19(15):4293 [1870982] Carcinogenesis. 1991 Oct;12(10):1939-44 [1934274] Carcinogenesis. 1994 Feb;15(2):247-52 [8313515] Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8413-7 [8078896] Br J Cancer. 1998 Mar;77(5):709-19 [9514048] Carcinogenesis. 1998 Nov;19(11):1949-53 [9855008] Chem Res Toxicol. 1999 Jul;12(7):623-9 [10409402] Mol Pharmacol. 1999 Oct;56(4):760-7 [10496959] Mar Biotechnol (NY). 2004 Jul-Aug;6(4):307-11 [15546046] Cancer Lett. 2005 Apr 28;221(2):213-24 [15808407] Toxicol Lett. 2006 Mar 15;162(1):3-15 [16321483] Mol Pharmacol. 2006 Apr;69(4):1103-14 [16377763] Arch Environ Health. 2004 Dec;59(12):640-9 [16789472] Toxicol Lett. 2006 Dec 15;167(3):173-82 [17049425] Chem Res Toxicol. 2007 Mar;20(3):424-31 [17295519] Carcinogenesis. 2007 Mar;28(3):611-24 [16973675] Epidemiology. 2007 May;18(3):373-82 [17435448] Cancer. 2007 Jun 15;109(12 Suppl):2667-711 [17503436] Drug Metab Dispos. 2007 Jul;35(7):1009-16 [17431034] Carcinogenesis. 2007 Jul;28(7):1426-9 [17277232] Chem Res Toxicol. 2008 Jan;21(1):70-83 [18052394] Environ Mol Mutagen. 2009 Mar;50(2):134-44 [19152381] Int J Cancer. 2010 Nov 15;127(10):2334-50 [20127859] IARC Monogr Eval Carcinog Risks Hum. 2010;92:1-853 [21141735] Breast Cancer Res Treat. 2011 Sep;129(2):477-84 [21452020] Int J Environ Res Public Health. 2011 Jul;8(7):2675-91 [21845152] Toxicol Lett. 2012 Sep 3;213(2):160-6 [22759596] Carcinogenesis. 2000 Jul;21(7):1433-40 [10874023] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/geu049 ER - TY - JOUR T1 - Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) production and Lactobacillus species growth in a defined medium simulating vaginal secretions. AN - 1566819655; 25135489 AB - Lactobacillus species are commensal with the healthy vaginal environment and inhibit the growth of many pathogenic bacteria in the vaginal tract by a variety of mechanisms, such as the production of hydrogen peroxide, organic acids, and antimicrobial substances. Simulation of the vaginal environment is crucial for proper investigation of the effects of Lactobacillus species on pathogenic bacteria. In this study, we modified a medium used to simulate vaginal secretions to improve the growth of toxic shock syndrome toxin-1 (TSST-1)-producing Staphylococcus aureus clinical strains and Lactobacillus species so that interactions between these bacteria may be examined. A medium consisting of basal salts, vitamins, albumin, glycogen, mucin, urea, sodium bicarbonate, polyoxyethylene sorbitan monolaurate, and amino acids supported the growth of S. aureus and the production of TSST-1 as determined by Western analysis. Improved growth of the Lactobacillus species was seen when this same medium was supplemented with manganese chloride, sodium acetate, and an increase in glucose concentration. However, growth of S. aureus in the supplemented medium resulted in reduced levels of TSST-1. Production of TSST-1 was not detected in a medium routinely used for the growth of Lactobacillus species although S. aureus growth was not inhibited. The development of an improved genital tract secretion medium provides a more authentic environment in which to study the interactions of Lactobacillus species and vaginal pathogens, such as S. aureus. Published by Elsevier B.V. JF - Journal of microbiological methods AU - Stingley, Robin L AU - Liu, Huanli AU - Mullis, Lisa B AU - Elkins, Christopher A AU - Hart, Mark E AD - Office of Scientific Coordination, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Office of Regulatory Affairs, Arkansas Regional Laboratories, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA. ; Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, USA. ; Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: mark.hart@fda.hhs.gov. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 57 EP - 66 VL - 106 KW - Bacterial Toxins KW - 0 KW - Culture Media KW - Enterotoxins KW - Superantigens KW - enterotoxin F, Staphylococcal KW - Index Medicus KW - In vitro growth KW - Lactobacillus species KW - TSST-1 KW - Menstrual toxic shock syndrome KW - Staphylococcus aureus KW - Simulated genital tract secretion medium KW - Vagina -- chemistry KW - Humans KW - Body Fluids -- chemistry KW - Female KW - Staphylococcus aureus -- physiology KW - Lactobacillus -- physiology KW - Enterotoxins -- secretion KW - Staphylococcus aureus -- growth & development KW - Microbial Interactions KW - Lactobacillus -- growth & development KW - Staphylococcus aureus -- metabolism KW - Culture Media -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566819655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+microbiological+methods&rft.atitle=Staphylococcus+aureus+toxic+shock+syndrome+toxin-1+%28TSST-1%29+production+and+Lactobacillus+species+growth+in+a+defined+medium+simulating+vaginal+secretions.&rft.au=Stingley%2C+Robin+L%3BLiu%2C+Huanli%3BMullis%2C+Lisa+B%3BElkins%2C+Christopher+A%3BHart%2C+Mark+E&rft.aulast=Stingley&rft.aufirst=Robin&rft.date=2014-11-01&rft.volume=106&rft.issue=&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Journal+of+microbiological+methods&rft.issn=1872-8359&rft_id=info:doi/10.1016%2Fj.mimet.2014.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-03 N1 - Date created - 2014-09-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.mimet.2014.08.002 ER - TY - JOUR T1 - EU alerting and reporting systems for potential chemical public health threats and hazards. AN - 1564606917; 25023642 AB - A number of European and international IT platforms are used to notify competent authorities of new potential chemical exposures. Recently the European Parliament and the Council of European Union adopted new legislation that aims to improve the co-ordinated response to cross border health threats (Decision 1082/2013/EU). The Decision, inter alia, sets provisions on notification, ad hoc monitoring and coordination of public health measures following serious cross border threats to health from biological, chemical and environmental events as well as events that have an unknown origin. The legal instrument applies to all European Union Member States and is comparable to the International Health Regulations in its content, requirements and adoption of a multiple hazards approach. An inter-sectoral and multidisciplinary response to events with potentially dangerous cross border exposure pathways is often required. For example, European Poisons Centres may be aware of cases of toxic exposure to a product and, in parallel, trading standards may be aware of the same product due to a breach of consumer product standards. Whilst both cases would have been recorded for separate purposes in different alerting systems, they relate to the same exposure pathway; therefore a process for linking these records would allow a more robust approach to risk assessment and risk mitigation. The Decision seeks to reconcile this issue for serious threats by linking relevant platforms into one overarching higher level risk management IT platform called the Early Warning Response System (EWRS). This system will serve to link other sectors within the European Commission (EC) to public health (e.g. medicines), as well as other EU agencies and international bodies via co-notification features. Other European alert systems will be linked to EWRS to facilitate information sharing at both the assessment and management levels. This paper provides a timely overview of the main systems run by the EC and other international organisations that provide alerts following chemical incidents that have, or may have, the potential to affect public health. The advantages and further considerations of linking these different systems and sectors are also highlighted. Recommendations are made with the purpose of ensuring that modifications to these systems made to satisfy with EU legislation enable a more timely coordinated response and greater awareness of events in Europe, thereby reducing the public health impact from chemical exposures. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Orford, R AU - Crabbe, H AU - Hague, C AU - Schaper, A AU - Duarte-Davidson, R AD - International Research and Development Group, Centre for Radiation, Chemicals and Environmental Hazards, Public Health England, UK. Electronic address: Rob.Orford@phe.gov.uk. ; International Research and Development Group, Centre for Radiation, Chemicals and Environmental Hazards, Public Health England, UK. ; GIZ-Nord Poisons Centre, Goettingen, Germany. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 15 EP - 25 VL - 72 KW - Street Drugs KW - 0 KW - Index Medicus KW - Hazards KW - Chemicals KW - EWRS KW - RASCHEM KW - Alerting KW - Reporting KW - Food Contamination -- prevention & control KW - Adverse Drug Reaction Reporting Systems -- legislation & jurisprudence KW - Accidents, Occupational -- prevention & control KW - European Union KW - Chemical Hazard Release -- legislation & jurisprudence KW - International Cooperation KW - Humans KW - Food Contamination -- legislation & jurisprudence KW - Street Drugs -- legislation & jurisprudence KW - Accidents, Occupational -- legislation & jurisprudence KW - Chemical Hazard Release -- prevention & control KW - Risk Assessment KW - Public Health -- methods KW - Public Health -- legislation & jurisprudence KW - Public Health -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1564606917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=EU+alerting+and+reporting+systems+for+potential+chemical+public+health+threats+and+hazards.&rft.au=Orford%2C+R%3BCrabbe%2C+H%3BHague%2C+C%3BSchaper%2C+A%3BDuarte-Davidson%2C+R&rft.aulast=Orford&rft.aufirst=R&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.006 ER - TY - JOUR T1 - Responding to biological incidents--what are the current issues in remediation of the contaminated environment? AN - 1552808032; 24530001 AB - Since 2000 there have been a number of biological incidents resulting in environmental contamination with Bacillus anthracis, the causative agent of anthrax. These incidents include the US anthrax attacks in 2001, the US and UK drumming incidents in 2006-2008 and more recently, anthrax contamination of heroin in 2009/2010 and 2012/2013. Remediation techniques used to return environments to normal have varied between incidents, with different decontamination technologies being employed. Many factors need to be considered before a remediation strategy or recovery option can be implemented, including; cost, time (length of application), public perception of risk, and sampling strategies (and results) to name a few. These incidents have demonstrated that consolidated guidance for remediating biologically contaminated environments in the aftermath of a biological incident was required. The UK Recovery Handbook for Biological Incidents (UKRHBI) is a project led by Public Health England (PHE), formerly the Health Protection Agency (HPA) to provide guidance and advice on how to remediate the environment following a biological incident or outbreak of infection, and is expected to be published in 2015. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved. JF - Environment international AU - Pottage, T AU - Goode, E AU - Wyke, S AU - Bennett, A M AD - Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. Electronic address: Thomas.pottage@phe.gov.uk. ; Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. ; Centre for Radiation, Chemicals and Environmental Hazards, Public Health England, Chilton OX11 0RQ, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 133 EP - 139 VL - 72 KW - Index Medicus KW - Remediation KW - Decontamination KW - Anthrax KW - Bioterrorism KW - Bacillus anthracis KW - Bacillus anthracis -- isolation & purification KW - Disaster Planning -- economics KW - Humans KW - Delivery of Health Care KW - Anthrax -- pathology KW - Anthrax -- prevention & control KW - Anthrax -- microbiology KW - Bacillus anthracis -- physiology KW - Risk Assessment KW - Decontamination -- methods KW - Decontamination -- economics KW - Biohazard Release -- prevention & control KW - Environmental Restoration and Remediation -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552808032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Responding+to+biological+incidents--what+are+the+current+issues+in+remediation+of+the+contaminated+environment%3F&rft.au=Pottage%2C+T%3BGoode%2C+E%3BWyke%2C+S%3BBennett%2C+A+M&rft.aulast=Pottage&rft.aufirst=T&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.01.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.01.018 ER - TY - JOUR T1 - Recent advances to address European Union Health Security from cross border chemical health threats. AN - 1552808003; 24679379 AB - The European Union (EU) Decision (1082/2013/EU) on serious cross border threats to health was adopted by the European Parliament in November 2013, in recognition of the need to strengthen the capacity of Member States to coordinate the public health response to cross border threats, whether from biological, chemical, environmental events or events which have an unknown origin. Although mechanisms have been in place for years for reporting cross border health threats from communicable diseases, this has not been the case for incidents involving chemicals and/or environmental events. A variety of collaborative EU projects have been funded over the past 10 years through the Health Programme to address gaps in knowledge on health security and to improve resilience and response to major incidents involving chemicals. This paper looks at the EU Health Programme that underpins recent research activities to address gaps in resilience, planning, responding to and recovering from a cross border chemical incident. It also looks at how the outputs from the research programme will contribute to improving public health management of transnational incidents that have the potential to overwhelm national capabilities, putting this into context with the new requirements as the Decision on serious cross border threats to health as well as highlighting areas for future development. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved. JF - Environment international AU - Duarte-Davidson, R AU - Orford, R AU - Wyke, S AU - Griffiths, M AU - Amlôt, R AU - Chilcott, R AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Electronic address: raquel.duarte-davidson@phe.gov.uk. ; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. ; Microbial Risk Assessment & Behavioural Science, Emergency Response Department, Public Health England, UK. ; Department of Pharmacy, University of Hertfordshire, Hatfield, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 3 EP - 14 VL - 72 KW - Index Medicus KW - CBRN KW - Cross border health threats KW - Alerting and notification KW - Chemical incident KW - Emergency response KW - Public health risk assessment and management KW - Radioactive Hazard Release -- legislation & jurisprudence KW - Environmental Pollution -- prevention & control KW - Health Planning KW - European Union KW - Chemical Hazard Release -- legislation & jurisprudence KW - Environmental Pollution -- legislation & jurisprudence KW - Humans KW - Biohazard Release -- prevention & control KW - Chemical Hazard Release -- prevention & control KW - Biohazard Release -- legislation & jurisprudence KW - Risk Assessment KW - Radioactive Hazard Release -- prevention & control KW - Public Health -- legislation & jurisprudence KW - Safety Management -- trends KW - Safety Management -- legislation & jurisprudence KW - Public Health -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552808003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Recent+advances+to+address+European+Union+Health+Security+from+cross+border+chemical+health+threats.&rft.au=Duarte-Davidson%2C+R%3BOrford%2C+R%3BWyke%2C+S%3BGriffiths%2C+M%3BAml%C3%B4t%2C+R%3BChilcott%2C+R&rft.aulast=Duarte-Davidson&rft.aufirst=R&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.01.003 ER - TY - JOUR T1 - Development of a risk-based prioritisation methodology to inform public health emergency planning and preparedness in case of accidental spill at sea of hazardous and noxious substances (HNS). AN - 1552807995; 24953645 AB - Hazardous and noxious chemicals are increasingly being transported by sea. Current estimates indicate some 2000 hazardous and noxious substances (HNS) are carried regularly by sea with bulk trade of 165milliontonnes per year worldwide. Over 100 incidents involving HNS have been reported in EU waters. Incidents occurring in a port or coastal area can have potential and actual public health implications. A methodology has been developed for prioritisation of HNS, based upon potential public health risks. The work, undertaken for the Atlantic Region Pollution Response programme (ARCOPOL), aims to provide information for incident planning and preparedness. HNS were assessed using conventional methodology based upon acute toxicity, behaviour and reactivity. Tonnage was used as a proxy for likelihood, although other factors such as shipping frequency and local navigation may also contribute. Analysis of 350 individual HNS identified the highest priority HNS as being those that present an inhalation risk. Limitations were identified around obtaining accurate data on HNS handled on a local and regional level due to a lack of port records and also political and commercial confidentiality issues. To account for this the project also developed a software tool capable of combining chemical data from the study with user defined shipping data to be used by operators to produce area-specific prioritisations. In conclusion a risk prioritisation matrix has been developed to assess the acute risks to public health from the transportation of HNS. Its potential use in emergency planning and preparedness is discussed. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Harold, P D AU - de Souza, A S AU - Louchart, P AU - Russell, D AU - Brunt, H AD - Public Health England CRCE, C/O Cardiff Metropolitan University Western Avenue, Cardiff, Wales, United Kingdom. Electronic address: paul.harold@phe.gov.uk. ; Public Health Wales, Wales, United Kingdom. ; Pembrokeshire County Council, Wales, United Kingdom. ; Public Health England CRCE, C/O Cardiff Metropolitan University Western Avenue, Cardiff, Wales, United Kingdom. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 157 EP - 163 VL - 72 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Risk prioritisation KW - Emergency planning and preparedness KW - Public health risk KW - HNS incidents KW - Software KW - Oceans and Seas KW - Humans KW - Risk Assessment KW - Hazardous Substances -- chemistry KW - Civil Defense -- methods KW - Public Health KW - Hazardous Substances -- metabolism KW - Chemical Hazard Release KW - Disaster Planning -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Development+of+a+risk-based+prioritisation+methodology+to+inform+public+health+emergency+planning+and+preparedness+in+case+of+accidental+spill+at+sea+of+hazardous+and+noxious+substances+%28HNS%29.&rft.au=Harold%2C+P+D%3Bde+Souza%2C+A+S%3BLouchart%2C+P%3BRussell%2C+D%3BBrunt%2C+H&rft.aulast=Harold&rft.aufirst=P&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.012 ER - TY - JOUR T1 - Recent developments in assessing and managing serious health threats. AN - 1552807947; 24970671 JF - Environment international AU - Duarte-Davidson, R AU - Griffiths, M AU - Wyke, S AU - Bradley, Naima AD - Public Health England, Centre for Radiation, Chemicals and Environmental Hazards, Oxon, UK. Electronic address: raquel.duarte-davidson@phe.gov.uk. ; Public Health England, Centre for Radiation, Chemicals and Environmental Hazards, Oxon, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 1 EP - 2 VL - 72 KW - Index Medicus KW - Humans KW - Biohazard Release -- prevention & control KW - Chemical Hazard Release -- prevention & control KW - Radioactive Hazard Release -- prevention & control KW - Public Health -- legislation & jurisprudence KW - Public Health -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Recent+developments+in+assessing+and+managing+serious+health+threats.&rft.au=Duarte-Davidson%2C+R%3BGriffiths%2C+M%3BWyke%2C+S%3BBradley%2C+Naima&rft.aulast=Duarte-Davidson&rft.aufirst=R&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.06.001 ER - TY - JOUR T1 - Assessing and improving cross-border chemical incident preparedness and response across Europe. AN - 1552807922; 24768281 AB - Good practices in emergency preparedness and response for chemical incidents include practices specific to the different functions of exposure assessment (e.g., within the monitoring function, the use of mobile monitoring equipment; within the modelling function, the use of rapid dispersion models with integrated mapping software) and generic practices to engage incident response stakeholders to maximise exposure assessment capabilities (e.g., sharing protocols and pre-prepared information and multi-agency training and exercising). Such practices can optimise cross-border collaboration. A wide range of practices have been implemented across MSs during chemical incident response, particularly during incidents that have cross-border and trans-boundary impacts. This paper proposes a self-assessment methodology to enable MSs, or organisations within MSs, to examine exposure assessment capabilities and communication pathways between exposure assessors and public health risk assessors. Where gaps exist, this methodology provides links to good practices that could improve response, communication and collaboration across local, regional and national borders. A fragmented approach to emergency preparedness for chemical incidents is a major obstacle to improving cross-border exposure assessment. There is no one existing body or structure responsible for all aspects of chemical incident preparedness and response in the European Union. Due to the range of different organisations and networks involved in chemical incident response, emergency preparedness needs to be drawn together. A number of recommendations are proposed, including the use of networks of experts which link public health risk assessors with experts in exposure assessment, in order to coordinate and improve chemical incident emergency preparedness. The EU's recent Decision on serious cross-border threats to health aims to facilitate MSs' compliance with the International Health Regulations, which require reporting and communication regarding significant chemical incidents. This provides a potential route to build on in order to improve chemical incident preparedness and response across Europe. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Stewart-Evans, James AU - Hall, Lisbeth AU - Czerczak, Slawomir AU - Manley, Kevin AU - Dobney, Alec AU - Hoffer, Sally AU - Pałaszewska-Tkacz, Anna AU - Jankowska, Agnieszka AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Institute of Population Health, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK. Electronic address: james.stewart-evans@phe.gov.uk. ; Centre for Environmental Safety and Security, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands. ; Chemical Safety Department, Nofer Institute of Occupational Medicine Poland, 91-348 Lodz, 8 Sw. Teresy Street, Poland. ; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Citygate, Gallowgate, Newcastle Upon Tyne NE1 4WH, UK. ; Public Health England, Centre for Radiation, Chemical and Environmental Hazards, St. Philips Place, Birmingham B3 2PW, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 30 EP - 36 VL - 72 KW - Index Medicus KW - Risk assessment KW - Emergency planning KW - Chemical incident KW - Emergency preparedness KW - Emergency response KW - Exposure assessment KW - Environmental Pollution -- prevention & control KW - Environmental Monitoring KW - European Union KW - Humans KW - Health Services Needs and Demand -- legislation & jurisprudence KW - Self-Assessment KW - Chemical Hazard Release -- legislation & jurisprudence KW - Disaster Planning -- standards KW - Chemical Hazard Release -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Assessing+and+improving+cross-border+chemical+incident+preparedness+and+response+across+Europe.&rft.au=Stewart-Evans%2C+James%3BHall%2C+Lisbeth%3BCzerczak%2C+Slawomir%3BManley%2C+Kevin%3BDobney%2C+Alec%3BHoffer%2C+Sally%3BPa%C5%82aszewska-Tkacz%2C+Anna%3BJankowska%2C+Agnieszka&rft.aulast=Stewart-Evans&rft.aufirst=James&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.03.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.03.012 ER - TY - JOUR T1 - The importance of evaluating the physicochemical and toxicological properties of a contaminant for remediating environments affected by chemical incidents. AN - 1552807668; 24874001 AB - In the event of a major chemical incident or accident, appropriate tools and technical guidance need to be available to ensure that a robust approach can be adopted for developing a remediation strategy. Remediation and restoration strategies implemented in the aftermath of a chemical incident are a particular concern for public health. As a result an innovative methodology has been developed to help design an effective recovery strategy in the aftermath of a chemical incident that has been developed; the UK Recovery Handbook for Chemical Incidents (UKRHCI). The handbook consists of a six-step decision framework and the use of decision trees specifically designed for three different environments: food production systems, inhabited areas and water environments. It also provides a compendium of evidence-based recovery options (techniques or methods for remediation) that should be selected in relation to their efficacy for removing contaminants from the environment. Selection of effective recovery options in this decision framework involves evaluating the physicochemical and toxicological properties of the chemical(s) involved. Thus, the chemical handbook includes a series of tables with relevant physicochemical and toxicological properties that should be assessed in function of the environment affected. It is essential that the physicochemical properties of a chemical are evaluated and interpreted correctly during the development of a remedial plan in the aftermath of a chemical incident to ensure an effective remedial response. This paper presents a general overview of the key physicochemical and toxicological properties of chemicals that should be evaluated when developing a recovery strategy. Information on how physicochemical properties have impacted on previous remedial responses reported in the literature is also discussed and a number of challenges for remediation are highlighted to include the need to develop novel approaches to remediate sites contaminated by mixtures of chemicals as well as methods for interpreting chemical reactions in different environmental matrices to include how climate change may affect the speciation and mobility of chemicals in the environment. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Wyke, S AU - Peña-Fernández, A AU - Brooke, N AU - Duarte-Davidson, R AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Electronic address: Stacey.wyke@phe.gov.uk. ; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 109 EP - 118 VL - 72 KW - Gases KW - 0 KW - Hazardous Substances KW - Soil KW - Water KW - 059QF0KO0R KW - Index Medicus KW - Environmental decontamination KW - Physicochemical and toxicological properties KW - Chemical incident KW - Recovery and restoration KW - Gases -- chemistry KW - Viscosity KW - Solubility KW - Food Chain KW - Humans KW - Water -- chemistry KW - Chemical Phenomena KW - Soil -- chemistry KW - Surface Properties KW - Hazardous Substances -- chemistry KW - Environmental Restoration and Remediation KW - Hazardous Substances -- metabolism KW - Chemical Hazard Release KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=The+importance+of+evaluating+the+physicochemical+and+toxicological+properties+of+a+contaminant+for+remediating+environments+affected+by+chemical+incidents.&rft.au=Wyke%2C+S%3BPe%C3%B1a-Fern%C3%A1ndez%2C+A%3BBrooke%2C+N%3BDuarte-Davidson%2C+R&rft.aulast=Wyke&rft.aufirst=S&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.002 ER - TY - JOUR T1 - Preparedness for a major incident: creation of an epidemiology protocol for a health protection register in England. AN - 1552807650; 24928282 AB - Large incidents and natural disasters are on the increase globally. They can have a major impact lasting many years or decades; and can affect large groups of people including those that are more susceptible to adverse consequences. Following a major incident, it may be considered necessary to establish a register of those people affected by the incident to provide appropriate advice on relevant immediate and longer-term public health interventions that may be required, provide reassurance to the public that their care is paramount, to reassure the worried well to avoid them inappropriately overwhelming local services, and to facilitate epidemiological investigations. Arrangements for the prompt follow-up of populations after large incidents or disasters have been agreed in England and a protocol for establishing a register of individuals potentially affected by a large incident has been developed. It is important for countries to have a protocol for implementing a health register if the circumstances require one to be in place, and are supported by Public Health Authorities. Health registers facilitate the initial descriptive epidemiology of exposure and provide the opportunity of carrying out long term analytical studies on the affected population. Such epidemiological studies provide a greater understanding of the impact that a large incident can have on health, which in turn helps in the planning of health care provision. Registers can also assist more directly in providing access to individuals in need of physical and mental health interventions. The challenge that still remains is to formally pilot the register in the field and refine it based on that experience. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Close, R M AU - Maguire, H AU - Etherington, G AU - Brewin, C R AU - Fong, K AU - Saliba, V AU - Barker, R M AU - Leonardi, G S AD - Department of Epidemiology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK; Field Epidemiology Training Programme (FETP), Public Health England, UK; European Programme for Intervention Epidemiology Training, ECDC, Stockholm, Sweden. Electronic address: rebecca.close@phe.gov.uk. ; European Programme for Intervention Epidemiology Training, ECDC, Stockholm, Sweden; Field Epidemiology Services, Public Health England, Victoria, London, UK. ; Department of Toxicology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. ; Department of Psychology, University College London, UK. ; Department of Emergency Medicine, University College Hospital, London, UK. ; North East & North Central London Health Protection Team, Public Health England, London, UK. ; Emergency Response Department, Public Health England, UK. ; Department of Epidemiology, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK; London School of Hygiene and Tropical Medicine, London, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 75 EP - 82 VL - 72 KW - Index Medicus KW - Health register KW - Major incident KW - Epidemiological follow-up KW - Epidemiologic Studies KW - Humans KW - Disaster Planning -- standards KW - Disaster Planning -- legislation & jurisprudence KW - England KW - Civil Defense -- methods KW - Health Services Needs and Demand -- legislation & jurisprudence KW - Civil Defense -- legislation & jurisprudence KW - Civil Defense -- standards KW - Health Services Needs and Demand -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Preparedness+for+a+major+incident%3A+creation+of+an+epidemiology+protocol+for+a+health+protection+register+in+England.&rft.au=Close%2C+R+M%3BMaguire%2C+H%3BEtherington%2C+G%3BBrewin%2C+C+R%3BFong%2C+K%3BSaliba%2C+V%3BBarker%2C+R+M%3BLeonardi%2C+G+S&rft.aulast=Close&rft.aufirst=R&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.003 ER - TY - JOUR T1 - Establishing the importance of human health risk assessment for metals and metalloids in urban environments. AN - 1552807645; 24791693 AB - Rapid development, industrialisation, and urbanisation have resulted in serious contamination of soil by metals and metalloids from anthropogenic sources in many areas of the world, either directly or indirectly. Exponential urban and economic development has resulted in human populations settling in urban areas and as a result being exposed to these pollutants. Depending on the nature of the contaminant, contaminated urban soils can have a deleterious effect on the health of exposed populations and may require decontamination, recovery, remediation and restoration. Therefore, human health risk assessments in urban environments are very important. In the case of Spain, there are few studies regarding risk assessment of trace elements in urban soils, and those that exist have been derived mainly from areas potentially exposed to industrial contamination or in the vicinity of point pollution. The present study analysed Al, As, Be, Cd, Cr, Cu, Hg, Mn, Ni, Pb, Sn, Ti, Tl, V and Zn soil concentrations in and around the city of Alcalá de Henares (35 km NE of Madrid). Soil samples were collected in public parks and recreation areas within the city and in an industrial area on the periphery of the city. From these results, an assessment of the health risk for the population was performed following the methodology described by the US EPA (1989). In general, it was observed that there could be a potential increased risk of developing cancer over a lifetime from exposure to arsenic (As) through ingestion of the soils studied (oral intake), as well as an increased risk of cancer due to inhalation of chromium (Cr) present in re-suspended soils from the industrial area. Our group has previously reported (Granero and Domingo, 2002; Peña-Fernández et al., 2003) that there was an increased risk of developing cancer following exposure to As in the same soils in a previous study. Therefore, it is necessary to reduce the levels of contaminants in these soils, especially As and Cr as these have been found to exceed safe levels for human health. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Peña-Fernández, A AU - González-Muñoz, M J AU - Lobo-Bedmar, M C AD - Universidad de Alcalá, Unidad Docente de Toxicología, Departamento de Ciencias Biomédicas, Crta. Madrid-Barcelona km. 33.6, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: Antonio.Pena-Fernandez@phe.gov.uk. ; Universidad de Alcalá, Unidad Docente de Toxicología, Departamento de Ciencias Biomédicas, Crta. Madrid-Barcelona km. 33.6, 28871 Alcalá de Henares, Madrid, Spain. ; Instituto Madrileño de Investigación y Desarrollo Rural Agrario y Alimentario (IMIDRA), Finca el Encín, Crta. Madrid-Barcelona km. 38.2, 28800 Alcalá de Henares, Madrid, Spain. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 176 EP - 185 VL - 72 KW - Metalloids KW - 0 KW - Metals KW - Soil Pollutants KW - Chromium KW - 0R0008Q3JB KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Human risk assessment KW - Urban soils KW - Contaminated soil KW - Metals and metalloids KW - Cities KW - Arsenic -- analysis KW - Chromium -- analysis KW - Humans KW - Principal Component Analysis KW - Environmental Exposure -- prevention & control KW - Risk Assessment KW - Environmental Monitoring KW - Metalloids -- analysis KW - Soil Pollutants -- chemistry KW - Metals -- analysis KW - Soil Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Establishing+the+importance+of+human+health+risk+assessment+for+metals+and+metalloids+in+urban+environments.&rft.au=Pe%C3%B1a-Fern%C3%A1ndez%2C+A%3BGonz%C3%A1lez-Mu%C3%B1oz%2C+M+J%3BLobo-Bedmar%2C+M+C&rft.aulast=Pe%C3%B1a-Fern%C3%A1ndez&rft.aufirst=A&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.04.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.04.007 ER - TY - JOUR T1 - Factors influencing recovery and restoration following a chemical incident. AN - 1552807582; 24874002 AB - Chemicals are an important part of our society. A wide range of chemicals are discharged into the environment every day from residential, commercial and industrial sources. Many of these discharges do not pose a threat to public health or the environment. However, global events have shown that chemical incidents or accidents can have severe consequences on human health, the environment and society. It is important that appropriate tools and technical guidance are available to ensure that a robust and efficient approach to developing a remediation strategy is adopted. The purpose of remediation is to protect human health from future exposure and to return the affected area back to normal as soon as possible. There are a range of recovery options (techniques or methods for remediation) that are applicable to a broad range of chemicals and incidents. Recovery options should be evaluated according to their appropriateness and efficacy for removing contaminants from the environment; however economic drivers and social and political considerations often influence decision makers on which remedial actions are implemented during the recovery phase of a chemical incident. To date, there is limited information in the literature on remediation strategies and recovery options that have been implemented following a chemical incident, or how successful they have been. Additional factors that can affect the approach taken for recovery are not well assessed or understood by decision makers involved in the remediation and restoration of the environment following a chemical incident. The identification of this gap has led to the development of the UK Recovery Handbook for Chemical Incidents to provide a framework for choosing an effective recovery strategy. A compendium of practical evidence-based recovery options (techniques or methods for remediation) for inhabited areas, food production systems and water environments has also been developed and is included in the chemical handbook. This paper presents the key factors that should be considered when developing a recovery strategy with respect to how these may impact on its effectiveness. The paper also highlights the importance of these factors through an evaluation of recovery strategies implemented following real chemical incidents that have been reported in the literature. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Peña-Fernández, A AU - Wyke, S AU - Brooke, N AU - Duarte-Davidson, R AD - Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Electronic address: Antonio.Pena-Fernandez@phe.gov.uk. ; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, UK. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 98 EP - 108 VL - 72 KW - Index Medicus KW - factors KW - effectiveness of remediation KW - chemical incident KW - Recovery and restoration KW - Environmental Pollution -- prevention & control KW - Environmental Monitoring KW - Humans KW - Groundwater -- analysis KW - Decontamination KW - Environmental Pollution -- analysis KW - Risk Assessment KW - Disaster Planning -- methods KW - Chemical Hazard Release -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552807582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Factors+influencing+recovery+and+restoration+following+a+chemical+incident.&rft.au=Pe%C3%B1a-Fern%C3%A1ndez%2C+A%3BWyke%2C+S%3BBrooke%2C+N%3BDuarte-Davidson%2C+R&rft.aulast=Pe%C3%B1a-Fern%C3%A1ndez&rft.aufirst=A&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=98&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.05.001 ER - TY - JOUR T1 - Monitoring lead in hair of children and adolescents of Alcalá de Henares, Spain. A study by gender and residential areas. AN - 1552806727; 24679380 AB - In recent years there has been an increased interest from the European Union (EU) in the development of large Human Bio-monitoring (HBM) studies across Europe, especially biomonitoring toxic metals. In Spain, most studies using hair as a biomarker have been conducted to determine occupational or industrial exposures, and have involved adult populations. Few studies have involved adolescents and children, despite these groups being sensitive to environmental contamination and pollutants. Therefore, the objective of the present study was to determine the degree of lead exposure in children and adolescents residing in Alcalá de Henares, Spain. Lead poisoning is the number one toxicological threat in the environment. So, lead (Pb) was selected as it is a persistent environmental contaminant, is measureable and is also a neurotoxin that can affect brain development. The city of Alcalá de Henares was divided into four zones to determine the influence of residence area on Pb levels. A range of other variables including age and gender were also considered within the study. The study comprised 115 children (6-9 years old) and 96 adolescents (13-16 years old). There was a significant difference between the levels of Pb in the hair of adolescents, for different gender and area of residence (p<0.001 and p<0.01 respectively). There was no significant difference in the Pb levels in hair of children, for different gender or area of the city. The levels of Pb were significantly (p<0.001) elevated in children compared to adolescents (1.48 vs. 0.70 μg/g), and there was a significant difference in Pb levels in male and female adolescent hair (0.53 vs. 0.77 μg/g) (p<0.001). The association observed between areas of residence and the Pb level in hair of the adolescent group could be mainly attributed to dietary habits and/or socioeconomic status. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environment international AU - Peña-Fernández, A AU - Lobo-Bedmar, M C AU - González-Muñoz, M J AD - Universidad de Alcalá, Unidad de Toxicología, Departamento de Ciencias Biomédicas, Crta. Madrid-Barcelona Km, 33.6, 28871 Alcalá de Henares, Madrid, Spain. Electronic address: Antonio.Pena-Fernandez@phe.gov.uk. ; Instituto Madrileño de Investigación y Desarrollo Rural Agrario y Alimentario (IMIDRA), Finca el Encín, Crta. Madrid-Barcelona Km, 38.2, 28800 Alcalá de Henares, Madrid, Spain. ; Universidad de Alcalá, Unidad de Toxicología, Departamento de Ciencias Biomédicas, Crta. Madrid-Barcelona Km, 33.6, 28871 Alcalá de Henares, Madrid, Spain. Y1 - 2014/11// PY - 2014 DA - November 2014 SP - 170 EP - 175 VL - 72 KW - Environmental Pollutants KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Age and gender KW - Monitoring KW - Children and adolescents KW - Human hair KW - Age Factors KW - Sex Factors KW - Spain KW - Humans KW - Child KW - Residence Characteristics KW - Adolescent KW - Male KW - Female KW - Environmental Monitoring KW - Hair -- chemistry KW - Environmental Pollutants -- analysis KW - Lead -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552806727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environment+international&rft.atitle=Monitoring+lead+in+hair+of+children+and+adolescents+of+Alcal%C3%A1+de+Henares%2C+Spain.+A+study+by+gender+and+residential+areas.&rft.au=Pe%C3%B1a-Fern%C3%A1ndez%2C+A%3BLobo-Bedmar%2C+M+C%3BGonz%C3%A1lez-Mu%C3%B1oz%2C+M+J&rft.aulast=Pe%C3%B1a-Fern%C3%A1ndez&rft.aufirst=A&rft.date=2014-11-01&rft.volume=72&rft.issue=&rft.spage=170&rft.isbn=&rft.btitle=&rft.title=Environment+international&rft.issn=1873-6750&rft_id=info:doi/10.1016%2Fj.envint.2014.03.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-09 N1 - Date created - 2014-08-09 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envint.2014.03.010 ER - TY - JOUR T1 - Systemic DNA damage accumulation under in vivo tumor growth can be inhibited by the antioxidant Tempol. AN - 1561969754; 25069035 AB - Recently we found that mice bearing subcutaneous non-metastatic tumors exhibited elevated levels of two types of complex DNA damage, i.e., double-strand breaks and oxidatively-induced clustered DNA lesions in various tissues throughout the body, both adjacent to and distant from the tumor site. This DNA damage was dependent on CCL2, a cytokine involved in the recruitment and activation of macrophages, suggesting that this systemic DNA damage was mediated via tumor-induced chronic inflammatory responses involving cytokines, activation of macrophages, and consequent free radical production. If free radicals are involved, then a diet containing an antioxidant may decrease the distant DNA damage. Here we repeated our standard protocol in cohorts of two syngeneic tumor-bearing C57BL/6NCr mice that were on a Tempol-supplemented diet. We show that double-strand break and oxidatively-induced clustered DNA lesion levels were considerably decreased, about two- to three fold, in the majority of tissues studied from the tumor-bearing mice fed the antioxidant Tempol compared to the control tumor-bearing mice. Similar results were also observed in nude mice suggesting that the Tempol effects are independent of functioning adaptive immunity. This is the first in vivo study demonstrating the effect of a dietary antioxidant on abscopal DNA damage in tissues distant from a localized source of genotoxic stress. These findings may be important for understanding the mechanisms of genomic instability and carcinogenesis caused by chronic stress-induced systemic DNA damage and for developing preventative strategies. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Cancer letters AU - Georgakilas, Alexandros G AU - Redon, Christophe E AU - Ferguson, Nicholas F AU - Kryston, Thomas B AU - Parekh, Palak AU - Dickey, Jennifer S AU - Nakamura, Asako J AU - Mitchell, James B AU - Bonner, William M AU - Martin, Olga A AD - Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA; Department of Physics, National Technical University of Athens, Zografou Campus, Athens GR-15773, Greece. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ; Department of Biology, Thomas Harriot College of Arts and Sciences, East Carolina University, Greenville, NC 27858, USA. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Office of In Vitro Diagnostics, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, USA. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Department of Biological Sciences, Faculty of Science, Ibaraki University, Ibaraki 310-8512, Japan. ; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. ; Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA; Division of Radiation Oncology and Cancer Imaging, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Laboratory of Molecular Radiation Biology, Peter MacCallum Cancer Centre, Vic. 3002, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Vic. 3002, Australia. Electronic address: olga.martin@petermac.org. Y1 - 2014/10/28/ PY - 2014 DA - 2014 Oct 28 SP - 248 EP - 257 VL - 353 IS - 2 KW - Antioxidants KW - 0 KW - Cyclic N-Oxides KW - Reactive Oxygen Species KW - Spin Labels KW - tempol KW - U78ZX2F65X KW - Index Medicus KW - DNA damage KW - Tumor-bearing mice KW - Non-targeted effects KW - Tempol KW - Neoplasm Transplantation KW - Reactive Oxygen Species -- metabolism KW - Animals KW - Gastrointestinal Tract -- pathology KW - Gastrointestinal Tract -- drug effects KW - Mice, Inbred C57BL KW - Mice, Nude KW - Mice KW - Female KW - Antioxidants -- pharmacology KW - Cyclic N-Oxides -- pharmacology KW - DNA Breaks, Double-Stranded KW - Melanoma, Experimental -- genetics KW - Carcinoma, Lewis Lung -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561969754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Systemic+DNA+damage+accumulation+under+in+vivo+tumor+growth+can+be+inhibited+by+the+antioxidant+Tempol.&rft.au=Georgakilas%2C+Alexandros+G%3BRedon%2C+Christophe+E%3BFerguson%2C+Nicholas+F%3BKryston%2C+Thomas+B%3BParekh%2C+Palak%3BDickey%2C+Jennifer+S%3BNakamura%2C+Asako+J%3BMitchell%2C+James+B%3BBonner%2C+William+M%3BMartin%2C+Olga+A&rft.aulast=Georgakilas&rft.aufirst=Alexandros&rft.date=2014-10-28&rft.volume=353&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2014.07.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-11 N1 - Date created - 2014-09-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Free Radic Biol Med. 2003 Jan 1;34(1):93-102 [12498984] Neurosci Res. 2003 Jan;45(1):1-8 [12507718] Nat Rev Cancer. 2003 Apr;3(4):276-85 [12671666] Am J Physiol Cell Physiol. 2003 Aug;285(2):C353-69 [12686516] Cancer Biol Ther. 2003 May-Jun;2(3):233-5 [12878854] Mutat Res. 2003 Oct 29;531(1-2):93-107 [14637248] Br J Pharmacol. 2004 Jan;141(1):105-13 [14656807] Hypertension. 2004 Feb;43(2):329-34 [14707156] Nat Cell Biol. 2004 Feb;6(2):168-70 [14755273] Mutagenesis. 2004 May;19(3):169-85 [15123782] Hepatology. 2004 Jun;39(6):1663-72 [15185308] Clin Cancer Res. 2004 Oct 1;10(19):6411-7 [15475427] Cancer Res. 1991 Feb 1;51(3):794-8 [1846317] Int J Radiat Oncol Biol Phys. 1992;22(4):803-6 [1544853] FEBS Lett. 1995 Jan 16;358(1):1-3 [7821417] Free Radic Biol Med. 1997;23(6):879-84 [9378367] Radiat Res. 2005 Mar;163(3):316-23 [15733038] Hum Mol Genet. 2005 Jun 15;14(12):1699-708 [15888486] Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14641-6 [16203985] Oncogene. 2005 Nov 10;24(49):7257-65 [16170376] Mutat Res. 2006 May 11;597(1-2):113-8 [16413041] Mutat Res. 2010 Feb;696(1):16-20 [20018253] Free Radic Biol Med. 2010 Mar 1;48(5):704-12 [20035861] Nat Rev Mol Cell Biol. 2010 Mar;11(3):220-8 [20177397] Oncologist. 2010;15(4):360-71 [20413641] Cancer Metastasis Rev. 2010 Jun;29(2):351-78 [20386957] J Biomed Opt. 2010 Mar-Apr;15(2):027006 [20459280] Mutat Res. 2010 Apr-Jun;704(1-3):152-9 [20060490] Cell Cycle. 2010 Aug 15;9(16):3256-76 [20814239] Chem Biol Interact. 2010 Nov 5;188(2):350-8 [20371364] Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17992-7 [20855610] Free Radic Biol Med. 2011 Feb 1;50(3):459-68 [21130158] Acta Cytol. 2010 Nov-Dec;54(6):1127-9 [21428160] Cancer Res. 2011 May 15;71(10):3437-41 [21558390] Mutat Res. 2011 Jun 3;711(1-2):142-9 [21185842] Mutat Res. 2011 Jun 3;711(1-2):193-201 [21216256] Free Radic Biol Med. 2011 Aug 1;51(3):780-90 [21664459] Cancer Immunol Immunother. 2011 Aug;60(8):1161-71 [21626032] Cell Cycle. 2011 Aug 1;10(15):2504-20 [21778829] J Thorac Cardiovasc Surg. 2011 Nov;142(5):1254-62 [21843894] Mutagenesis. 2012 Jan;27(1):77-86 [21980144] Cancer Res. 2012 Jun 1;72(11):2768-79 [22472119] Int J Radiat Oncol Biol Phys. 2012 Jul 15;83(4):1284-90 [22197226] Curr Mol Med. 2012 Jul 1;12(6):672-80 [22292435] Cancer Res. 2012 Sep 15;72(18):4846-55 [22805306] Cancer Lett. 2012 Dec 31;327(1-2):123-33 [22198208] Nucleic Acids Res. 2012 Nov 1;40(20):10274-86 [22941641] Radiat Res. 2013 Jul;180(1):100-9 [23682596] PLoS One. 2013;8(8):e70575 [23940596] Cancer Lett. 2015 Jan 1;356(1):72-81 [24041866] Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):103-8 [10618378] J Neurosurg. 2000 Apr;92(4):646-51 [10761655] Cancer J Sci Am. 1996 Sep-Oct;2(5):273-8 [9166544] J Leukoc Biol. 2006 Oct;80(4):705-13 [16864600] Eur J Pharmacol. 2006 Nov 7;549(1-3):50-7 [16989807] J Nutr. 2007 Jan;137(1 Suppl):229S-232S [17182831] Radiat Res. 2007 Feb;167(2):207-16 [17390728] Free Radic Biol Med. 2007 Jun 1;42(11):1632-50 [17462532] Cancer Res. 2007 May 1;67(9):4295-302 [17483342] Cell Cycle. 2007 Sep 15;6(18):2210-2 [17881892] Radiat Res. 2007 Nov;168(5):527-34 [17973547] Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2726-37 [17675574] Mol Biosyst. 2008 Jan;4(1):30-5 [18075671] Oncogene. 2008 Jan 17;27(4):434-40 [17621264] Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):554-62 [18207032] Aging Cell. 2008 Jan;7(1):89-100 [18005250] Nat Rev Cancer. 2008 Mar;8(3):180-92 [18273037] Nat Genet. 2008 Mar;40(3):356-61 [18246068] Cancer Res. 2008 Mar 1;68(5):1601-8 [18316625] J Radiat Res. 2008 May;49(3):203-10 [18413977] Cell Cycle. 2008 May 1;7(9):1238-45 [18418050] Science. 2008 Jun 13;320(5882):1507-10 [18483401] Nature. 2008 Jul 24;454(7203):436-44 [18650914] Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12445-50 [18711141] Cancer Res. 2008 Sep 1;68(17):7059-65 [18757420] Nat Rev Cancer. 2008 Dec;8(12):957-67 [19005492] PLoS Biol. 2008 Dec 2;6(12):2853-68 [19053174] Mutat Res. 2009 Mar 31;674(1-2):131-6 [18948225] Blood. 2000 Jul 1;96(1):307-13 [10891466] Oncogene. 2006 Jul 20;25(31):4267-75 [16532033] Nat Rev Cancer. 2009 May;9(5):351-60 [19377507] NMR Biomed. 2009 Jun;22(5):532-7 [19156686] Carcinogenesis. 2009 Oct;30(10):1686-95 [19651821] Int J Radiat Oncol Biol Phys. 2009 Nov 15;75(4):1247-53 [19857788] Chromosoma. 2009 Dec;118(6):683-92 [19707781] Am J Physiol Renal Physiol. 2010 Jan;298(1):F86-94 [19906952] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.canlet.2014.07.030 ER - TY - JOUR T1 - Technology-Based Interventions in Social Work Practice: A Systematic Review of Mental Health Interventions AN - 1680149817; 201503539 AB - Despite concerns around the use of technology-based interventions, they are increasingly being employed by social workers as a direct practice methodology to address the mental health needs of vulnerable clients. Researchers have highlighted the importance of using innovative technologies within social work practice, yet little has been done to summarize the evidence and collectively assess findings. In this systematic review, we describe accounts of technology-based mental health interventions delivered by social workers over the past 10 years. Results highlight the impacts of these tools and summarize advantages and disadvantages to utilizing technologies as a method for delivering or facilitating interventions. Adapted from the source document. JF - Social Work in Health Care AU - Ramsey, Alex T AU - Montgomery, Katherine AD - Center for Mental Health Services Research, Brown School of Social Work, Washington University in St. Louis, St. Louis, Missouri, USA Y1 - 2014/10/21/ PY - 2014 DA - 2014 Oct 21 SP - 883 EP - 899 PB - Taylor & Francis, Philadelphia PA VL - 53 IS - 9 SN - 0098-1389, 0098-1389 KW - Social Workers KW - Intervention KW - Mental Health KW - Vulnerability KW - Social Work KW - article KW - 6140: illness & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680149817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Technology-Based+Interventions+in+Social+Work+Practice%3A+A+Systematic+Review+of+Mental+Health+Interventions&rft.au=Ramsey%2C+Alex+T%3BMontgomery%2C+Katherine&rft.aulast=Ramsey&rft.aufirst=Alex&rft.date=2014-10-21&rft.volume=53&rft.issue=9&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/10.1080%2F00981389.2014.925531 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-05-01 N1 - Last updated - 2016-09-28 N1 - CODEN - SWHCDO N1 - SubjectsTermNotLitGenreText - Intervention; Mental Health; Social Work; Social Workers; Vulnerability DO - http://dx.doi.org/10.1080/00981389.2014.925531 ER - TY - JOUR T1 - Reaction of dehydropyrrolizidine alkaloids with valine and hemoglobin. AN - 1614700268; 25211425 AB - Pyrrolizidine alkaloid-containing plants are probably the most common poisonous plants affecting livestock, wildlife, and humans. Pyrrolizidine alkaloids exert toxicity through metabolism to dehydropyrrolizidine alkaloids that bind to cellular protein and DNA, leading to hepatotoxicity, genotoxicity, and tumorigenicity. To date, it is not clear how dehydropyrrolizidine alkaloids bind to cellular constituents, including amino acids and proteins, resulting in toxicity. Metabolism of carcinogenic monocrotaline, riddelliine, and heliotrine produces dehydromonocrotaline, dehyroriddelliine, and dehydroheliotrine, respectively, as primary reactive metabolites. In this study, we report that reaction of dehydromonocrotaline with valine generated four highly unstable 6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived valine (DHP-valine) adducts. For structural elucidation, DHP-valine adducts were derivatized with phenyl isothiocyanate (PITC) to DHP-valine-PITC products. After HPLC separation, their structures were characterized by mass spectrometry, UV-visible spectrophotometry, (1)H NMR, and (1)H-(1)H COSY NMR spectral analysis. Two DHP-valine-PITC adducts, designated as DHP-valine-PITC-1 and DHP-valine-PITC-3, had the amino group of valine linked to the C7 position of the necine base, and the other two DHP-valine-PITC products, DHP-valine-PITC-2 and DHP-valine-PITC-4, linked to the C9 position of the necine base. DHP-valine-PITC-1 was interconvertible with DHP-valine-PITC-3, and DHP-valine-PITC-2 was interconvertible with DHP-valine-PITC-4. Reaction of dehydroriddelliine and dehydroheliotrine with valine provided similar results. However, reaction of valine and dehydroretronecine (DHR) under similar experimental conditions did not produce DHP-valine adducts. Reaction of dehydromonocrotaline with rat hemoglobin followed by derivatization with PITC also generated the same four DHP-valine-PITC adducts. This represents the first full structural elucidation of protein conjugated pyrrolic adducts formed from reaction of dehydropyrrolizidine alkaloids with an amino acid (valine). In addition, it was found that DHP-valine-2 and DHP-valine-4, with the valine amino group linked at the C7 position of the necine base, can lose the valine moiety to form DHP. JF - Chemical research in toxicology AU - Zhao, Yuewei AU - Wang, Shuguang AU - Xia, Qingsu AU - Gamboa da Costa, Gonçalo AU - Doerge, Daniel R AU - Cai, Lining AU - Fu, Peter P AD - National Center for Toxicological Research , Jefferson, Arkansas 72079, United States. Y1 - 2014/10/20/ PY - 2014 DA - 2014 Oct 20 SP - 1720 EP - 1731 VL - 27 IS - 10 KW - Alkaloids KW - 0 KW - Hemoglobins KW - Isothiocyanates KW - Pyrrolizidine Alkaloids KW - phenylisothiocyanate KW - 0D58F84LSU KW - riddelliine KW - 23246-96-0 KW - Monocrotaline KW - 73077K8HYV KW - Valine KW - HG18B9YRS7 KW - dehydroretronecine KW - QG6MWR17OH KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Monocrotaline -- analogs & derivatives KW - Tandem Mass Spectrometry KW - Monocrotaline -- chemistry KW - Isothiocyanates -- chemistry KW - Female KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Alkaloids -- chemistry KW - Hemoglobins -- chemistry KW - Valine -- chemistry KW - Pyrrolizidine Alkaloids -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1614700268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Reaction+of+dehydropyrrolizidine+alkaloids+with+valine+and+hemoglobin.&rft.au=Zhao%2C+Yuewei%3BWang%2C+Shuguang%3BXia%2C+Qingsu%3BGamboa+da+Costa%2C+Gon%C3%A7alo%3BDoerge%2C+Daniel+R%3BCai%2C+Lining%3BFu%2C+Peter+P&rft.aulast=Zhao&rft.aufirst=Yuewei&rft.date=2014-10-20&rft.volume=27&rft.issue=10&rft.spage=1720&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx5002139 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-23 N1 - Date created - 2014-10-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/tx5002139 ER - TY - JOUR T1 - Stat3 signaling regulates embryonic stem cell fate in a dose-dependent manner AN - 1808683230; PQ0003451472 AB - Stat3 is essential for mouse embryonic stem cell (mESC) self-renewal mediated by LIF/gp130 receptor signaling. Current understanding of Stat3-mediated ESC self-renewal mechanisms is very limited, and has heretofore been dominated by the view that Stat3 signaling functions in a binary "on/off" manner. Here, in contrast to this binary viewpoint, we demonstrate a contextual, rheostat-like mechanism for Stat3's function in mESCs. Activation and expression levels determine whether Stat3 functions in a self-renewal or a differentiation role in mESCs. We also show that Stat3 induces rapid differentiation of mESCs toward the trophectoderm (TE) lineage when its activation level exceeds certain thresholds. Stat3 induces this differentiation phenotype via induction of Tfap2c and its downstream target Cdx2. Our findings provide a novel concept in the realm of Stat3, self-renewal signaling, and pluripotent stem cell biology. Ultimately, this finding may facilitate the development of conditions for the establishment of authentic non-rodent ESCs. JF - Biology Open AU - Tai, Chih-I AU - Schulze, Eric N AU - Ying, Qi-Long AD - Present address: Animal Biotechnology Interdisciplinary Group, Center for Veterinary Medicine, United States Food and Drug Administration, 7500 Standish Place, Rockville, MD 20855, USA Y1 - 2014/10/15/ PY - 2014 DA - 2014 Oct 15 SP - 958 EP - 965 PB - The Company of Biologists Ltd., 140 Cowley Rd Cambridge, CB4 0DL United Kingdom VL - 3 IS - 10 SN - 2046-6390, 2046-6390 KW - Biotechnology and Bioengineering Abstracts KW - Stat3 KW - Embryonic stem cell KW - Pluripotency KW - Differentiation KW - Stem cells KW - Glycoprotein gp130 KW - CDX2 protein KW - Embryo cells KW - Stat3 protein KW - trophectoderm KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808683230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+Open&rft.atitle=Stat3+signaling+regulates+embryonic+stem+cell+fate+in+a+dose-dependent+manner&rft.au=Tai%2C+Chih-I%3BSchulze%2C+Eric+N%3BYing%2C+Qi-Long&rft.aulast=Tai&rft.aufirst=Chih-I&rft.date=2014-10-15&rft.volume=3&rft.issue=10&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Biology+Open&rft.issn=20466390&rft_id=info:doi/10.1242%2Fbio.20149514 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Differentiation; Glycoprotein gp130; Stem cells; CDX2 protein; Embryo cells; Stat3 protein; trophectoderm DO - http://dx.doi.org/10.1242/bio.20149514 ER - TY - JOUR T1 - Is organic farming safer to farmers' health? A comparison between organic and traditional farming. AN - 1563986646; 24576785 AB - Exposure to pesticides is a major public health concern, because of the widespread distribution of these compounds and their possible long term effects. Recently, organic farming has been introduced as a consumer and environmental friendly agricultural system, although little is known about the effects on workers' health. The aim of this work was to evaluate genetic damage and immunological alterations in workers of both traditional and organic farming. Eighty-five farmers exposed to several pesticides, thirty-six organic farmers and sixty-one controls took part in the study. Biomarkers of exposure (pyrethroids, organophosphates, carbamates, and thioethers in urine and butyrylcholinesterase activity in plasma), early effect (micronuclei in lymphocytes and reticulocytes, T-cell receptor mutation assay, chromosomal aberrations, comet assay and lymphocytes subpopulations) and susceptibility (genetic polymorphisms related to metabolism - EPHX1, GSTM1, GSTT1 and GSTP1 - and DNA repair-XRCC1 and XRCC2) were evaluated. When compared to controls and organic farmers, pesticide farmers presented a significant increase of micronuclei in lymphocytes (frequency ratio, FR=2.80) and reticulocytes (FR=1.89), chromosomal aberrations (FR=2.19), DNA damage assessed by comet assay (mean ratio, MR=1.71), and a significant decrease in the proportion of B lymphocytes (MR=0.88). Results were not consistent for organic farmers when compared to controls, with a 48% increase of micronuclei in lumphocytes frequency (p=0.016) contrasted by the significant decreases of TCR-Mf (p=0.001) and %T (p=0.001). Our data confirm the increased presence of DNA damage in farmers exposed to pesticides, and show as exposure conditions may influence observed effects. These results must be interpreted with caution due to the small size of the sample and the unbalanced distribution of individuals in the three study groups. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology letters AU - Costa, Carla AU - García-Lestón, Julia AU - Costa, Solange AU - Coelho, Patrícia AU - Silva, Susana AU - Pingarilho, Marta AU - Valdiglesias, Vanessa AU - Mattei, Francesca AU - Dall'Armi, Valentina AU - Bonassi, Stefano AU - Laffon, Blanca AU - Snawder, John AU - Teixeira, João Paulo AD - Department of Environmental Health, Portuguese National Institute of Health, Rua Alexandre Herculano, 321, 4000-055 Porto, Portugal. Electronic address: cstcosta@gmail.com. ; Toxicology Unit, Department of Psychobiology, University of A Coruña, Edificio de Servicios Centrales de Investigación, Campus Elviña s/n, 15071 A Coruña, Spain. ; Department of Environmental Health, Portuguese National Institute of Health, Rua Alexandre Herculano, 321, 4000-055 Porto, Portugal. ; Department of Genetics, Faculty of Medical Sciences UNL, Rua da Junqueira 100, 1349-008 Lisbon, Portugal. ; Toxicology Unit, Department of Psychobiology, University of A Coruña, Edificio de Servicios Centrales de Investigación, Campus Elviña s/n, 15071 A Coruña, Spain; Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Via di Val Cannuta, 247, 00166 Rome, Italy. ; Unit of Clinical and Molecular Epidemiology, IRCCS San Raffaele Pisana, Via di Val Cannuta, 247, 00166 Rome, Italy. ; Biomonitoring and Health Assessment Branch of the Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, United States of America. Y1 - 2014/10/15/ PY - 2014 DA - 2014 Oct 15 SP - 166 EP - 176 VL - 230 IS - 2 KW - Biomarkers KW - 0 KW - Pesticides KW - glutathione S-transferase T1 KW - EC 2.5.1.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Immunotoxicity KW - Genotoxicity KW - Organic farming KW - DNA Damage KW - Humans KW - Lymphocyte Subsets -- drug effects KW - Adult KW - Aged KW - Middle Aged KW - Glutathione Transferase -- genetics KW - Adolescent KW - Male KW - Female KW - Organic Agriculture KW - Occupational Exposure -- adverse effects KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1563986646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Is+organic+farming+safer+to+farmers%27+health%3F+A+comparison+between+organic+and+traditional+farming.&rft.au=Costa%2C+Carla%3BGarc%C3%ADa-Lest%C3%B3n%2C+Julia%3BCosta%2C+Solange%3BCoelho%2C+Patr%C3%ADcia%3BSilva%2C+Susana%3BPingarilho%2C+Marta%3BValdiglesias%2C+Vanessa%3BMattei%2C+Francesca%3BDall%27Armi%2C+Valentina%3BBonassi%2C+Stefano%3BLaffon%2C+Blanca%3BSnawder%2C+John%3BTeixeira%2C+Jo%C3%A3o+Paulo&rft.aulast=Costa&rft.aufirst=Carla&rft.date=2014-10-15&rft.volume=230&rft.issue=2&rft.spage=166&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2014.02.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-25 N1 - Date created - 2014-09-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cancer Epidemiol Biomarkers Prev. 1998 Nov;7(11):1013-8 [9829710] Mutat Res. 1999 May 17;441(2):225-37 [10333536] Cancer Res. 1999 Jun 1;59(11):2557-61 [10363972] Age Ageing. 1999 Jul;28(4):393-7 [10459794] Arch Environ Contam Toxicol. 1999 Oct;37(3):415-23 [10473800] Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):258-70 [15688363] Clin Immunol. 2005 Aug;116(2):192-7 [15993366] Hum Exp Toxicol. 2005 Sep;24(9):439-45 [16235732] Mutat Res. 2006 Mar;612(2):84-104 [16314140] Mutagenesis. 2006 Mar;21(2):143-8 [16540494] Mutagenesis. 2006 Mar;21(2):93-103 [16567350] Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):659-66 [16614106] Toxicology. 2006 Jun 15;223(3):219-26 [16713056] Environ Toxicol. 2006 Aug;21(4):355-9 [16841319] Cancer Detect Prev. 2007;31(4):303-9 [17935911] Mutat Res. 2008 Jul 31;654(2):168-75 [18603015] Toxicology. 2008 Oct 30;252(1-3):40-8 [18721846] Hum Exp Toxicol. 2008 Sep;27(9):671-80 [19042949] Cell Biol Toxicol. 2009 Feb;25(1):53-64 [18040874] Environ Int. 2009 Feb;35(2):273-8 [18678410] Trends Immunol. 2009 Jul;30(7):325-33 [19541535] J Toxicol Environ Health A. 2009;72(15-16):986-97 [19672767] Transpl Int. 2009 Nov;22(11):1041-50 [19624493] Thyroid. 2009 Oct;19(10):1067-75 [19772428] Mutat Res. 2010 Jul-Sep;705(1):11-9 [19932192] Mutat Res. 2011 Mar 18;721(1):81-8 [21241821] J Toxicol Environ Health A. 2011;74(15-16):960-70 [21707421] Mutat Res. 2011 Oct 9;725(1-2):36-42 [21736951] J Toxicol Environ Health A. 2012;75(13-15):807-18 [22788368] Environ Mol Mutagen. 2003;41(2):104-10 [12605379] Arch Environ Health. 1999 Nov-Dec;54(6):425-9 [10634232] Carcinogenesis. 2000 May;21(5):965-71 [10783319] Environ Res. 2000 May;83(1):67-71 [10845783] J Natl Cancer Inst Monogr. 2000;(27):113-24 [10963623] Cancer Epidemiol Biomarkers Prev. 2000 Oct;9(10):1005-15 [11045781] Immunol Today. 2000 Oct;21(10):515-21 [11071531] Ann Agric Environ Med. 2000;7(1):61-3 [10865247] Mutat Res. 2001 Apr 5;491(1-2):71-80 [11287300] Arch Environ Contam Toxicol. 2001 Jul;41(1):104-11 [11385596] Environ Health Perspect. 2001 May;109(5):495-500 [11401761] Cancer Epidemiol Biomarkers Prev. 2001 Dec;10(12):1239-48 [11751440] Mutagenesis. 2002 Jan;17(1):79-82 [11752238] Environ Mol Mutagen. 2002;39(2-3):208-15 [11921191] Free Radic Biol Med. 2002 Jul 1;33(1):37-44 [12086680] Mutagenesis. 2002 Sep;17(5):391-7 [12202626] J Appl Toxicol. 2002 Jul-Aug;22(4):249-55 [12210542] Mutat Res. 2002 Sep 26;520(1-2):83-91 [12297147] Environ Mol Mutagen. 2002;40(3):153-60 [12355548] Cancer Epidemiol Biomarkers Prev. 2003 May;12(5):439-43 [12750239] Mutat Res. 2003 Jun;543(3):251-72 [12787816] Biomedica. 2003 Jun;23(2):141-52 [12872553] Am J Clin Nutr. 2009 Sep;90(3):680-5 [19640946] Mutat Res. 2000 Nov 20;455(1-2):81-95 [11113469] Clin Diagn Lab Immunol. 2004 Jan;11(1):168-73 [14715565] Toxicology. 2004 Feb 15;195(2-3):231-42 [14751678] Mutat Res. 2004 Apr 14;548(1-2):27-33 [15063133] Cancer Genet Cytogenet. 2004 May;151(1):60-7 [15120911] Arch Toxikol. 1971;28(2):105-14 [5123870] Br J Ind Med. 1978 Aug;35(3):232-4 [698138] Br J Ind Med. 1981 Feb;38(1):98-100 [7470409] Ann Occup Hyg. 1981;24(1):77-92 [7015964] Clin Chem. 1985 Apr;31(4):546-50 [3978785] Int Arch Occup Environ Health. 1988;60(6):453-6 [3410555] Br J Ind Med. 1988 Aug;45(8):548-51 [3415921] Br J Ind Med. 1991 Feb;48(2):82-6 [1998612] Immunol Today. 1995 Jan;16(1):12-6 [7880382] Cancer Epidemiol Biomarkers Prev. 1995 Sep;4(6):671-9 [8547835] Lancet. 1996 Jun 29;347(9018):1844 [8667966] Carcinogenesis. 1997 Apr;18(4):641-4 [9111193] Mutat Res. 1998 May 25;400(1-2):467-78 [9685705] Exp Gerontol. 1998 Sep;33(6):593-600 [9789736] Food Chem Toxicol. 2006 Oct;44(10):1714-23 [16814914] Mutat Res. 2006 Oct 10;609(1):74-80 [16887377] Mutagenesis. 2006 Sep;21(5):343-50 [16980312] Environ Mol Mutagen. 2006 Oct;47(8):587-93 [16917935] J Pathol. 2007 Jan;211(2):144-56 [17200946] Immunology. 2007 Apr;120(4):435-46 [17313487] Int J Hyg Environ Health. 2007 May;210(3-4):415-8 [17320478] Environ Int. 2007 Oct;33(7):877-85 [17493680] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2014.02.011 ER - TY - JOUR T1 - Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential AN - 1654685937; PQ0001052561 AB - Background: Mitochondrial dysfunction has been implicated in the pathogenesis of a variety of disorders including cancer, diabetes, and neurodegenerative and cardiovascular diseases. Understanding whether different environmental chemicals and druglike molecules impact mitochondrial function represents an initial step in predicting exposure-related toxicity and defining a possible role for such compounds in the onset of various diseases. Objectives: We sought to identify individual chemicals and general structural features associated with changes in mitochondrial membrane potential (MMP). Methods: We used a multiplexed [two end points in one screen; MMP and adenosine triphosphate (ATP) content] quantitative high throughput screening (qHTS) approach combined with informatics tools to screen the Tox21 library of 10,000 compounds (~ 8,300 unique chemicals) at 15 concentrations each in triplicate to identify chemicals and structural features that are associated with changes in MMP in HepG2 cells. Results: Approximately 11% of the compounds (913 unique compounds) decreased MMP after 1 hr of treatment without affecting cell viability (ATP content). In addition, 309 compounds decreased MMP over a concentration range that also produced measurable cytotoxicity [half maximal inhibitory concentration (IC50) in MMP assay/IC50 in viability assay less than or equal to 3; p < 0.05]. More than 11% of the structural clusters that constitute the Tox21 library (76 of 651 clusters) were significantly enriched for compounds that decreased the MMP. Conclusions: Our multiplexed qHTS approach allowed us to generate a robust and reliable data set to evaluate the ability of thousands of drugs and environmental compounds to decrease MMP. The use of structure-based clustering analysis allowed us to identify molecular features that are likely responsible for the observed activity. Citation: Attene-Ramos MS, Huang R, Michael S, Witt KL, Richard A, Tice RR, Simeonov A, Austin CP, Xia M. 2015. Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential. Environ Health Perspect 123:49-56; http://dx.doi.org/10.1289/ehp.1408642 JF - Environmental Health Perspectives AU - Attene-Ramos, Matias S AU - Huang, Ruili AU - Michael, Sam AU - Witt, Kristine L AU - Richard, Ann AU - Tice, Raymond R AU - Simeonov, Anton AU - Austin, Christopher P AU - Xia, Menghang AD - National Center for Advancing Translational Sciences, National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, Maryland, USA Y1 - 2014/10/10/ PY - 2014 DA - 2014 Oct 10 SP - 49 EP - 56 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 123 IS - 1 SN - 0091-6765, 0091-6765 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Diabetes mellitus KW - Cytotoxicity KW - Membranes KW - Informatics KW - Toxicity KW - Cardiovascular diseases KW - Drugs KW - H 4000:Food and Drugs KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654685937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Profiling+of+the+Tox21+Chemical+Collection+for+Mitochondrial+Function+to+Identify+Compounds+that+Acutely+Decrease+Mitochondrial+Membrane+Potential&rft.au=Attene-Ramos%2C+Matias+S%3BHuang%2C+Ruili%3BMichael%2C+Sam%3BWitt%2C+Kristine+L%3BRichard%2C+Ann%3BTice%2C+Raymond+R%3BSimeonov%2C+Anton%3BAustin%2C+Christopher+P%3BXia%2C+Menghang&rft.aulast=Attene-Ramos&rft.aufirst=Matias&rft.date=2014-10-10&rft.volume=123&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1408642 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Diabetes mellitus; Cytotoxicity; Membranes; Informatics; Cardiovascular diseases; Toxicity; Drugs DO - http://dx.doi.org/10.1289/ehp.1408642 ER - TY - JOUR T1 - Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum. AN - 1609507281; 25290267 AB - Epigenetic mechanisms regulate programmed gene expression during prenatal neurogenesis and serve as a mediator between genetics and environment in postnatal life. The recent discovery of 5-hydroxymethylcytosine (5-hmC), with highest concentration in the brain, has added a new dimension to epigenetic regulation of neurogenesis and the development of complex behavior disorders. Here, we take a candidate gene approach to define the role 5-hmC in Engrailed-2 (EN-2) gene expression in the autism cerebellum. The EN-2 homeobox transcription factor, previously implicated in autism, is essential for normal cerebellar patterning and development. We previously reported EN-2 overexpression associated with promoter DNA hypermethylation in the autism cerebellum but because traditional DNA methylation methodology cannot distinguish 5-methylcytosine (5-mC) from 5-hmC, we now extend our investigation by quantifying global and gene-specific 5-mC and 5-hmC. Globally, 5-hmC was significantly increased in the autism cerebellum and accompanied by increases in the expression of de novo methyltransferases DNMT3A and DNMT3B, ten-eleven translocase genes TET1 and TET3, and in 8-oxo-deoxyguanosine (8-oxo-dG) content, a marker of oxidative DNA damage. Within the EN-2 promoter, there was a significant positive correlation between 5-hmC content and EN-2 gene expression. Based on reports of reduced MeCP2 affinity for 5-hmC, MeCP2 binding studies in the EN-2 promoter revealed a significant decrease in repressive MeCP2 binding that may contribute to the aberrant overexpression of EN-2. Because normal cerebellar development depends on perinatal EN-2 downregulation, the sustained postnatal overexpression suggests that a critical window of cerebellar development may have been missed in some individuals with autism with downstream developmental consequences. Epigenetic regulation of the programmed on-off switches in gene expression that occur at birth and during early brain development warrants further investigation. JF - Translational psychiatry AU - James, S J AU - Shpyleva, S AU - Melnyk, S AU - Pavliv, O AU - Pogribny, I P AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, AR, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA. Y1 - 2014/10/07/ PY - 2014 DA - 2014 Oct 07 SP - 1 VL - 4 KW - Homeodomain Proteins KW - 0 KW - Methyl-CpG-Binding Protein 2 KW - Nerve Tissue Proteins KW - engrailed 2 protein KW - 5-hydroxymethylcytosine KW - 1123-95-1 KW - Cytosine KW - 8J337D1HZY KW - Index Medicus KW - Humans KW - Promoter Regions, Genetic -- genetics KW - Adolescent KW - Male KW - Female KW - Methyl-CpG-Binding Protein 2 -- genetics KW - Homeodomain Proteins -- genetics KW - Gene Expression -- genetics KW - Autistic Disorder -- genetics KW - Nerve Tissue Proteins -- genetics KW - Cytosine -- analogs & derivatives KW - Autistic Disorder -- metabolism KW - Cytosine -- metabolism KW - Cerebellum -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609507281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Translational+psychiatry&rft.atitle=Elevated+5-hydroxymethylcytosine+in+the+Engrailed-2+%28EN-2%29+promoter+is+associated+with+increased+gene+expression+and+decreased+MeCP2+binding+in+autism+cerebellum.&rft.au=James%2C+S+J%3BShpyleva%2C+S%3BMelnyk%2C+S%3BPavliv%2C+O%3BPogribny%2C+I+P&rft.aulast=James&rft.aufirst=S&rft.date=2014-10-07&rft.volume=4&rft.issue=&rft.spage=e460&rft.isbn=&rft.btitle=&rft.title=Translational+psychiatry&rft.issn=2158-3188&rft_id=info:doi/10.1038%2Ftp.2014.87 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-02 N1 - Date created - 2014-10-08 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurosci. 1998 Mar 1;18(5):1763-73 [9465001] Mol Cell Neurosci. 2005 Jan;28(1):96-105 [15607945] Nat Rev Genet. 2006 Jun;7(6):415-26 [16708070] Mol Cell Biol. 2006 Jul;26(13):5033-42 [16782889] Brain Res. 2006 Oct 20;1116(1):166-76 [16935268] Behav Brain Res. 2007 Jan 10;176(1):121-32 [17055592] Mol Cell Neurosci. 2008 Aug;38(4):495-504 [18562208] Brain Res. 2008 Oct 27;1237:25-34 [18694733] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39 [19412858] Science. 2009 May 15;324(5929):929-30 [19372393] Chem Res Toxicol. 2009 May;22(5):788-97 [19309085] Cerebellum. 2009 Sep;8(3):366-72 [19357934] Nature. 2009 Sep 10;461(7261):199-205 [19741700] Biol Psychiatry. 2009 Nov 15;66(10):911-7 [19615670] Development. 2010 Feb;137(3):519-29 [20081196] BMC Neurosci. 2010;11:53 [20420693] Nucleic Acids Res. 2010 Jun;38(11):e125 [20371518] Genes Dev. 2011 Apr 1;25(7):679-84 [21460036] Nature. 2011 May 19;473(7347):394-7 [21552279] Epigenetics. 2011 Jul;6(7):853-6 [21617369] Neural Plast. 2011;2011:921680 [21826280] Nat Neurosci. 2011 Dec;14(12):1607-16 [22037496] Cancer Res. 2011 Dec 15;71(24):7360-5 [22052461] J Clin Exp Neuropsychol. 2012;34(1):35-56 [22047489] Nucleic Acids Res. 2012 Apr;40(7):2884-97 [22144686] Restor Neurol Neurosci. 2012;30(3):237-45 [22426040] Nucleic Acids Res. 2012 Jun;40(11):4841-9 [22362737] J Neurosci. 2012 Jun 6;32(23):7832-42 [22674259] Cerebellum. 2012 Sep;11(3):777-807 [22370873] Epigenomics. 2012 Aug;4(4):445-57 [22920183] Nucleic Acids Res. 2012 Sep 1;40(17):8255-65 [22730288] J Biol Chem. 2012 Sep 28;287(40):33116-21 [22898819] Cell. 2012 Dec 21;151(7):1417-30 [23260135] Transl Psychiatry. 2013;3:e232 [23423141] Cell Rep. 2013 Feb 21;3(2):291-300 [23403289] Nat Rev Mol Cell Biol. 2013 Jun;14(6):341-56 [23698584] Science. 2013 Aug 9;341(6146):1237905 [23828890] Mech Ageing Dev. 2013 Oct;134(10):486-95 [24012631] Transl Psychiatry. 2014;4:e349 [24448211] Neurobiol Aging. 2014 Jun;35(6):1334-44 [24387984] Mutat Res Genet Toxicol Environ Mutagen. 2014 Apr;764-765:18-35 [24045206] Genome Biol. 2014;15(3):R49 [24594098] PLoS One. 2011;6(4):e18844 [21526191] Environ Health Perspect. 2000 Jun;108 Suppl 3:511-33 [10852851] J Neurosci. 2001 Feb 1;21(3):788-97 [11157065] J Nutr. 2002 Aug;132(8 Suppl):2401S-2405S [12163700] J Comp Neurol. 2004 Apr 19;472(1):87-99 [15024754] Am J Med Genet B Neuropsychiatr Genet. 2004 May 15;127B(1):51-9 [15108180] Nucleic Acids Res. 2004;32(14):4100-8 [15302911] J Mol Biol. 1992 May 20;225(2):327-48 [1317461] J Biol Chem. 1993 Jan 5;268(1):613-9 [8093246] Development. 1996 Feb;122(2):627-35 [8625814] Chem Biol Interact. 1996 Jan 5;99(1-3):289-99 [8620576] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/tp.2014.87 ER - TY - JOUR T1 - The Yin: An adverse health perspective of nanoceria: uptake, distribution, accumulation, and mechanisms of its toxicity. AN - 1826601737; 25243070 AB - This critical review evolved from a SNO Special Workshop on Nanoceria panel presentation addressing the toxicological risks of nanoceria: accumulation, target organs, and issues of clearance; how exposure dose/concentration, exposure route, and experimental preparation/model influence the different reported effects of nanoceria; and how can safer by design concepts be applied to nanoceria? It focuses on the most relevant routes of human nanoceria exposure and uptake, disposition, persistence, and resultant adverse effects. The pulmonary, oral, dermal, and topical ocular exposure routes are addressed as well as the intravenous route, as the latter provides a reference for the pharmacokinetic fate of nanoceria once introduced into blood. Nanoceria reaching the blood is primarily distributed to mononuclear phagocytic system organs. Available data suggest nanoceria's distribution is not greatly affected by dose, shape, or dosing schedule. Significant attention has been paid to the inhalation exposure route. Nanoceria distribution from the lung to the rest of the body is less than 1% of the deposited dose, and from the gastrointestinal tract even less. Intracellular nanoceria and organ burdens persist for at least months, suggesting very slow clearance rates. The acute toxicity of nanoceria is very low. However, large/accumulated doses produce granuloma in the lung and liver, and fibrosis in the lung. Toxicity, including genotoxicity, increases with exposure time; the effects disappear slowly, possibly due to nanoceria's biopersistence. Nanoceria may exert toxicity through oxidative stress. Adverse effects seen at sites distal to exposure may be due to nanoceria translocation or released biomolecules. An example is elevated oxidative stress indicators in the brain, in the absence of appreciable brain nanoceria. Nanoceria may change its nature in biological environments and cause changes in biological molecules. Increased toxicity has been related to greater surface Ce3+, which becomes more relevant as particle size decreases and the ratio of surface area to volume increases. Given its biopersistence and resulting increased toxicity with time, there is a risk that long-term exposure to low nanoceria levels may eventually lead to adverse health effects. This critical review provides recommendations for research to resolve some of the many unknowns of nanoceria's fate and adverse effects. JF - Environmental science. Nano AU - Yokel, Robert A AU - Hussain, Salik AU - Garantziotis, Stavros AU - Demokritou, Philip AU - Castranova, Vincent AU - Cassee, Flemming R AD - Pharmaceutical Sciences, University of Kentucky, US ; Graduate Center for Toxicology, University of Kentucky, US. ; Clinical Research Unit, National Institute of Environmental Health Sciences, National Institutes of Health, US. ; Environmental Health, Harvard, US. ; National Institute for Occupational Safety and Health, US ; West Virginia University School of Pharmacy, Morgantown, WV, US. ; Centre for Sustainability, Environmental & Health, National Institute for Public Health and the Environment, Bilthoven, the Netherlands ; Institute of Risk Assessment Sciences, Utrecht University, Utrecht, the Netherlands. Y1 - 2014/10/01/ PY - 2014 DA - 2014 Oct 01 SP - 406 EP - 428 VL - 1 IS - 5 SN - 2051-8153, 2051-8153 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826601737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+science.+Nano&rft.atitle=The+Yin%3A+An+adverse+health+perspective+of+nanoceria%3A+uptake%2C+distribution%2C+accumulation%2C+and+mechanisms+of+its+toxicity.&rft.au=Yokel%2C+Robert+A%3BHussain%2C+Salik%3BGarantziotis%2C+Stavros%3BDemokritou%2C+Philip%3BCastranova%2C+Vincent%3BCassee%2C+Flemming+R&rft.aulast=Yokel&rft.aufirst=Robert&rft.date=2014-10-01&rft.volume=1&rft.issue=5&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Environmental+science.+Nano&rft.issn=20518153&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2014-09-22 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - FDA Approval Summary: Vemurafenib for Treatment of Unresectable or Metastatic Melanoma with the BRAFV600E Mutation AN - 1808643236; PQ0003450126 AB - On August 17, 2011, the U.S. Food and Drug Administration (FDA) approved vemurafenib tablets (Zelboraf, Hoffmann-LaRoche Inc.) for the treatment of patients with unresectable or metastatic melanoma with the BRAFV600E mutation as detected by an FDA-approved test. The cobas 4800 BRAF V600 Mutation Test (Roche Molecular Systems, Inc.) was approved concurrently. An international, multicenter, randomized, open-label trial in 675 previously untreated patients with BRAFV600E mutation-positive unresectable or metastatic melanoma allocated 337 patients to receive vemurafenib, 960 mg orally twice daily, and 338 patients to receive dacarbazine, 1,000 mg/m2 intravenously every 3 weeks. Overall survival was significantly improved in patients receiving vemurafenib [HR, 0.44; 95% confidence interval (CI), 0.33-0.59; P < 0.0001]. Progression-free survival was also significantly improved in patients receiving vemurafenib (HR, 0.26; 95% CI, 0.20-0.33; P < 0.0001). Overall response rates were 48.4% and 5.5% in the vemurafenib and dacarbazine arms, respectively. The most common adverse reactions ( greater than or equal to 30%) in patients treated with vemurafenib were arthralgia, rash, alopecia, fatigue, photosensitivity reaction, and nausea. Cutaneous squamous cell carcinomas or keratoacanthomas were detected in approximately 24% of patients treated with vemurafenib. Other adverse reactions included hypersensitivity, Stevens-Johnson syndrome, toxic epidermal necrolysis, uveitis, QT prolongation, and liver enzyme laboratory abnormalities. Clin Cancer Res; 20(19); 4994-5000. copyright 2014 AACR. JF - Clinical Cancer Research AU - Kim, Geoffrey AU - McKee, Amy E AU - Ning, Yang-Min AU - Hazarika, Maitreyee AU - Theoret, Marc AU - Johnson, John R AU - Xu, Qiang Casey AU - Tang, Shenghui AU - Sridhara, Rajeshwari AU - Jiang, Xiaoping AU - He, Kun AU - Roscoe, Donna AU - McGuinn, WDavid AU - Helms, Whitney S AU - Russell, Anne Marie AU - Miksinski, Sarah Pope AU - Zirkelbach, Jeanne Fourie AU - Earp, Justin AU - Liu, Qi AU - Ibrahim, Amna AU - Justice, Robert AU - Pazdur, Richard AD - Office of Hematology and Oncology Products (OHOP), Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, Geoffrey.Kim@fda.hhs.gov Y1 - 2014/10/01/ PY - 2014 DA - 2014 Oct 01 SP - 4994 EP - 5000 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 United States VL - 20 IS - 19 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Dacarbazine KW - Fatigue KW - Tablets KW - Enzymes KW - Survival KW - Stevens-Johnson syndrome KW - squamous cell carcinoma KW - Clinical trials KW - Cancer KW - Melanoma KW - Metastases KW - Exanthema KW - Hypersensitivity KW - Alopecia KW - Nausea KW - Mutation KW - Arthralgia KW - Side effects KW - Toxic epidermal necrolysis KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808643236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=FDA+Approval+Summary%3A+Vemurafenib+for+Treatment+of+Unresectable+or+Metastatic+Melanoma+with+the+BRAFV600E+Mutation&rft.au=Kim%2C+Geoffrey%3BMcKee%2C+Amy+E%3BNing%2C+Yang-Min%3BHazarika%2C+Maitreyee%3BTheoret%2C+Marc%3BJohnson%2C+John+R%3BXu%2C+Qiang+Casey%3BTang%2C+Shenghui%3BSridhara%2C+Rajeshwari%3BJiang%2C+Xiaoping%3BHe%2C+Kun%3BRoscoe%2C+Donna%3BMcGuinn%2C+WDavid%3BHelms%2C+Whitney+S%3BRussell%2C+Anne+Marie%3BMiksinski%2C+Sarah+Pope%3BZirkelbach%2C+Jeanne+Fourie%3BEarp%2C+Justin%3BLiu%2C+Qi%3BIbrahim%2C+Amna%3BJustice%2C+Robert%3BPazdur%2C+Richard&rft.aulast=Kim&rft.aufirst=Geoffrey&rft.date=2014-10-01&rft.volume=20&rft.issue=19&rft.spage=4994&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-14-0776 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - Fatigue; Dacarbazine; Tablets; Survival; Enzymes; squamous cell carcinoma; Stevens-Johnson syndrome; Clinical trials; Cancer; Melanoma; Metastases; Exanthema; Hypersensitivity; Alopecia; Nausea; Arthralgia; Mutation; Toxic epidermal necrolysis; Side effects DO - http://dx.doi.org/10.1158/1078-0432.CCR-14-0776 ER - TY - JOUR T1 - Characterization of Cross-Protection by Genetically Modified Live-Attenuated Leishmania donovani Parasites against Leishmania mexicana AN - 1808642749; PQ0003449461 AB - Previously, we showed that genetically modified live-attenuated Leishmania donovani parasite cell lines (LdCen-/- and Ldp27-/-) induce a strong cellular immunity and provide protection against visceral leishmaniasis in mice. In this study, we explored the mechanism of cross-protection against cutaneous lesion-causing Leishmania mexicana. Upon challenge with wild-type L. mexicana, mice immunized either for short or long periods showed significant protection. Immunohistochemical analysis of ears from immunized/challenged mice exhibited significant influx of macrophages, as well as cells expressing MHC class II and inducible NO synthase, suggesting an induction of potent host-protective proinflammatory responses. In contrast, substantial inhibition of IL-10, IL-4, and IL-13 expression and the absence of degranulated mast cells and less influx of eosinophils within the ears of immunized/challenged mice suggested a controlled anti-inflammatory response. L. mexicana Ag-stimulated lymph node cell culture from the immunized/challenged mice revealed induction of IFN- gamma secretion by the CD4 and CD8 T cells compared with non-immunized/challenged mice. We also observed suppression of Th2 cytokines in the culture supernatants of immunized/challenged lymph nodes compared with non-immunized/challenged mice. Adoptively transferred total T cells from immunized mice conferred strong protection in recipient mice against L. mexicana infection, suggesting that attenuated L. donovani can provide protection against heterologous L. mexicana parasites by induction of a strong T cell response. Furthermore, bone marrow-derived dendritic cells infected with LdCen-/- and Ldp27-/- parasites were capable of inducing a strong proinflammatory response leading to the proliferation of Th1 cells. These studies demonstrate the potential of live-attenuated L. donovani parasites as pan-Leishmania species vaccines. JF - Journal of Immunology AU - Dey, Ranadhir AU - Natarajan, Gayathri AU - Bhattacharya, Parna AU - Cummings, Hannah AU - Dagur, Pradeep K AU - Terrazas, Cesar AU - Selvapandiyan, Angamuthu AU - McCoy, John P AU - Duncan, Robert AU - Satoskar, Abhay R AU - Nakhasi, Hira L AD - Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993 Y1 - 2014/10/01/ PY - 2014 DA - 2014 Oct 01 SP - 3513 EP - 3527 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 United States VL - 193 IS - 7 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Macrophages KW - Parasites KW - gamma -Interferon KW - Interleukin 4 KW - Cross-protection KW - Helper cells KW - Bone marrow KW - Major histocompatibility complex KW - Cell culture KW - Ear KW - Leukocytes (eosinophilic) KW - Infection KW - Interleukin 10 KW - Leishmania donovani KW - Dendritic cells KW - Interleukin 13 KW - CD4 antigen KW - Lymphocytes T KW - Cytokines KW - Visceral leishmaniasis KW - Mast cells KW - CD8 antigen KW - Lymph nodes KW - Inflammation KW - Nitric-oxide synthase KW - Immunity (cell-mediated) KW - Vaccines KW - Leishmania mexicana KW - Cell proliferation KW - K 03350:Immunology KW - G 07790:Other Microorganisms KW - F 06915:Cancer Immunology KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808642749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Characterization+of+Cross-Protection+by+Genetically+Modified+Live-Attenuated+Leishmania+donovani+Parasites+against+Leishmania+mexicana&rft.au=Dey%2C+Ranadhir%3BNatarajan%2C+Gayathri%3BBhattacharya%2C+Parna%3BCummings%2C+Hannah%3BDagur%2C+Pradeep+K%3BTerrazas%2C+Cesar%3BSelvapandiyan%2C+Angamuthu%3BMcCoy%2C+John+P%3BDuncan%2C+Robert%3BSatoskar%2C+Abhay+R%3BNakhasi%2C+Hira+L&rft.aulast=Dey&rft.aufirst=Ranadhir&rft.date=2014-10-01&rft.volume=193&rft.issue=7&rft.spage=3513&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/10.4049%2Fjimmunol.1303145 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-14 N1 - SubjectsTermNotLitGenreText - Macrophages; gamma -Interferon; Parasites; Interleukin 4; Cross-protection; Helper cells; Bone marrow; Major histocompatibility complex; Ear; Cell culture; Leukocytes (eosinophilic); Infection; Interleukin 10; Dendritic cells; CD4 antigen; Interleukin 13; Lymphocytes T; Cytokines; Visceral leishmaniasis; Mast cells; CD8 antigen; Lymph nodes; Inflammation; Nitric-oxide synthase; Immunity (cell-mediated); Vaccines; Cell proliferation; Leishmania donovani; Leishmania mexicana DO - http://dx.doi.org/10.4049/jimmunol.1303145 ER - TY - JOUR T1 - Postscript: Research Agenda to Guide the Next Generation of Public Reports for Consumers AN - 1683509492 AB - There is significant interest in building the next generation of public reporting tools that will more effectively engage consumers and better enable them to make use of comparative performance information when selecting a provider. Demand for public reporting tools that make health care cost and quality information transparent is fueled by a variety of market forces underway. A host of public reporting efforts and studies have identified a number of challenges, highlighting that we still do not understand how best to design public reports to meet the needs of the consumer. We identify five areas for additional research that, if addressed, could foster better design and delivery of quality and cost information to consumers. JF - Medical Care Research and Review : MCRR AU - Damberg, Cheryl L AU - McNamara, Peggy AD - RAND Corporation, Santa Monica, CA, USA ; Agency for Healthcare Research and Quality, Rockville, MD, USA ; RAND Corporation, Santa Monica, CA, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 97S EP - 107S CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 71 IS - 5 SN - 1077-5587 KW - Public Health And Safety KW - consumer engagement in quality KW - public reporting KW - report cards KW - transparency KW - health care decision making KW - Consumers KW - Decision making KW - Health care KW - Health costs KW - Market forces KW - Transparency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683509492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review+%3A+MCRR&rft.atitle=Postscript%3A+Research+Agenda+to+Guide+the+Next+Generation+of+Public+Reports+for+Consumers&rft.au=Damberg%2C+Cheryl+L%3BMcNamara%2C+Peggy&rft.aulast=Damberg&rft.aufirst=Cheryl&rft.date=2014-10-01&rft.volume=71&rft.issue=5&rft.spage=97S&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review+%3A+MCRR&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558714535982 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-05-14 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.1177/1077558714535982 ER - TY - JOUR T1 - Statistical challenges in drug approval trials that use patient-reported outcomes* AN - 1683509220 AB - This article describes challenging aspects of the use of patient-reported outcome instruments in clinical trials for drug approval, in our perspective as statistical reviewers at the US Food and Drug Administration. We discuss aspects of planning and interpreting results in clinical trials (1) adapting an existing patient-reported outcome instrument for use in clinical trials, (2) using multi-item patient-reported outcomes and (3) missing patient-reported outcome values from many subjects over time. These challenges are illustrated with multiple examples from different clinical trials for different indications. We finally discuss important considerations in labeling. JF - Statistical Methods in Medical Research AU - Izem, Rima AU - Kammerman, Lisa A AU - Komo, Scott AD - Center for Drug Evaluations and Research, Food and Drug Administration, Silver Spring, MD, USA ; Center for Drug Evaluations and Research, Food and Drug Administration, Silver Spring, MD, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 398 EP - 408 CY - London PB - Sage Publications Ltd. VL - 23 IS - 5 SN - 0962-2802 KW - Medical Sciences KW - Patient-reported outcome KW - statistical review KW - Clinical research KW - Clinical trials KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683509220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Statistical+challenges+in+drug+approval+trials+that+use+patient-reported+outcomes*&rft.au=Izem%2C+Rima%3BKammerman%2C+Lisa+A%3BKomo%2C+Scott&rft.aulast=Izem&rft.aufirst=Rima&rft.date=2014-10-01&rft.volume=23&rft.issue=5&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280213476376 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - Food & Drug Administration--FDA N1 - Date revised - 2015-05-12 N1 - Last updated - 2016-05-12 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1177/0962280213476376 ER - TY - JOUR T1 - Public Reporting of Provider Performance at a Crossroads in the United States: Summary of Current Barriers and Recommendations on How to Move Forward AN - 1683508455 AB - Twenty-seven years after the first public release by the U.S. government of data on the quality of hospital care, public reporting for consumers has expanded substantially. Despite the growth in public reporting activities, there is limited evidence of their use by consumers in ways that significantly affect health care delivery. Support for public reporting continues, in part, because of the face value of transparency. The limited impact of reporting efforts is plausibly due to flaws in the content, design, and implementation of existing public reports rather than inherent limitations of reporting. Substantial work is still needed for public reports to achieve their potential for engaging and informing consumers. We present a vision statement and 10 recommendations to achieve this potential. JF - Medical Care Research and Review : MCRR AU - Hussey, Peter S AU - Luft, Harold S AU - McNamara, Peggy AD - RAND Corporation, Boston, MA, USA ; Palo Alto Medical Foundation, Palo Alto, CA, USA ; Agency for Healthcare Research and Quality, Rockville, MD, USA ; RAND Corporation, Boston, MA, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 5S EP - 16S CY - Thousand Oaks PB - SAGE PUBLICATIONS, INC. VL - 71 IS - 5 SN - 1077-5587 KW - Public Health And Safety KW - consumer engagement in quality KW - public reporting KW - report cards KW - transparency KW - health care decision making KW - Care delivery KW - Consumers KW - Decision making KW - Health care KW - Release KW - Service delivery KW - Transparency KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683508455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Care+Research+and+Review+%3A+MCRR&rft.atitle=Public+Reporting+of+Provider+Performance+at+a+Crossroads+in+the+United+States%3A+Summary+of+Current+Barriers+and+Recommendations+on+How+to+Move+Forward&rft.au=Hussey%2C+Peter+S%3BLuft%2C+Harold+S%3BMcNamara%2C+Peggy&rft.aulast=Hussey&rft.aufirst=Peter&rft.date=2014-10-01&rft.volume=71&rft.issue=5&rft.spage=5S&rft.isbn=&rft.btitle=&rft.title=Medical+Care+Research+and+Review+%3A+MCRR&rft.issn=10775587&rft_id=info:doi/10.1177%2F1077558714535980 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-05-15 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1177/1077558714535980 ER - TY - JOUR T1 - The Use of the Dutch Self-Sufficiency Matrix (SSM-D) to Inform Allocation Decisions to Public Mental Health Care for Homeless People AN - 1680149835; 201504033 AB - The current study set out to develop a decision support tool based on the Self-Sufficiency Matrix (Dutch version; SSM-D) for the clinical decision to allocate homeless people to the public mental health care system at the central access point of public mental health care in Amsterdam, The Netherlands. Logistic regression and receiver operating characteristic-curve analyses were used to model professional decisions and establish four decision categories based on SSM-D scores from half of the research population (Total n = 612). The model and decision categories were found to be accurate and reliable in predicting professional decisions in the second half of the population. Results indicate that the decision support tool based on the SSM-D is useful and feasible. The method to develop the SSM-D as a decision support tool could be applied to decision-making processes in other systems and services where the SSM-D has been implemented, to further increase the utility of the instrument. Adapted from the source document. JF - Community Mental Health Journal AU - Lauriks, Steve AU - Wit, Matty A S AU - Buster, Marcel C A AU - Fassaert, Thijs J L AU - Wifferen, Ron AU - Klazinga, Niek S AD - Department of Epidemiology and Health Promotion (E&G), Public Health Service Amsterdam (GGD Amsterdam), Nieuwe Achtergracht 100, 1018 WT, Amsterdam, The Netherlands slauriks@ggd.amsterdam.nl Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 870 EP - 878 PB - Springer, Dordrecht The Netherlands VL - 50 IS - 7 SN - 0010-3853, 0010-3853 KW - Delivery Systems KW - Decision Models KW - Access KW - Mental Health Services KW - Decision Making KW - Netherlands KW - Homelessness KW - Medical Decision Making KW - Decisions KW - article KW - 7211: health policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680149835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=The+Use+of+the+Dutch+Self-Sufficiency+Matrix+%28SSM-D%29+to+Inform+Allocation+Decisions+to+Public+Mental+Health+Care+for+Homeless+People&rft.au=Lauriks%2C+Steve%3BWit%2C+Matty+A+S%3BBuster%2C+Marcel+C+A%3BFassaert%2C+Thijs+J+L%3BWifferen%2C+Ron%3BKlazinga%2C+Niek+S&rft.aulast=Lauriks&rft.aufirst=Steve&rft.date=2014-10-01&rft.volume=50&rft.issue=7&rft.spage=870&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-014-9707-x LA - English DB - Social Services Abstracts N1 - Date revised - 2015-05-01 N1 - Number of references - 19 N1 - Last updated - 2016-09-28 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Decisions; Medical Decision Making; Mental Health Services; Netherlands; Homelessness; Decision Models; Access; Delivery Systems; Decision Making DO - http://dx.doi.org/10.1007/s10597-014-9707-x ER - TY - JOUR T1 - Diversity of Desulfobacteriaceae and Overall Activity of Sulfate-Reducing Microorganisms in and Around a Salt pan in a Southern California Coastal Wetland AN - 1647022998; 21172874 AB - Sulfate-reducing bacteria (SRB) are key mediators of anaerobic carbon cycling in coastal salt marsh sediments and have been shown to be important decomposer communities even in hypersaline habitats. Understanding how SRB function in various salt marsh habitats (vegetated, salt pans) is crucial to advancing our knowledge of salt marsh function. We compare overall sulfate reducing activity and the diversity of a subset of SRB (Desulfobacteriaceae) in two hypersaline sediments (salt pan and nearby area with desiccated vegetation) with a regularly inundated control site within the Huntington Beach Wetlands (HBW). Biological activity was quantified using radiotracer studies to measure sulfate reduction rates (SRR) with and without carbon amendment. All sites showed enhanced SRR under carbon amendment, suggesting short-term carbon limitation. Unique communities of Desulfobacteriaceae were found in all three sites with increased incidence of halotolerant genotypes in the salt pan. These findings indicate that, despite reduced anaerobic respiratory activity, highly diverse and functional deltaproteobacterial communities exist in salt pan and surrounding hypersaline habitats in coastal salt marshes in southern California. JF - Wetlands AU - Jackson, Karen L AU - Whitcraft, Christine R AU - Dillon, Jesse G AD - Department of Biological Sciences, California State University, 1250 Bellflower Blvd., Long Beach, CA, 90840, USA; United States Food and Drug Administration, 19701 Fairchild, Irvine, CA, 92603, USA Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 969 EP - 977 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 34 IS - 5 SN - 0277-5212, 0277-5212 KW - Meteorological & Geoastrophysical Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Ecology Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Coastal salt pan KW - Desulfobacteriaceae KW - Sulfate?-reducing bacteria KW - Sulfate reduction KW - Salt marshes KW - Anaerobic respiration KW - Genotypes KW - Diving physiology KW - Carbon KW - INE, USA, California, Huntington Beach KW - Decomposers KW - Wetlands KW - Sediment chemistry KW - Sulfate-reducing bacteria KW - Beaches KW - Carbon cycle KW - Vegetation KW - Salinity tolerance KW - Habitat KW - Sediments KW - Salts KW - Coastal zone KW - Species diversity KW - Microorganisms KW - Pans KW - Q1 08463:Habitat community studies KW - O 1010:Viruses, Bacteria, Protists, Fungi and Plants KW - A 01450:Environmental Pollution & Waste Treatment KW - D 04040:Ecosystem and Ecology Studies KW - M2 556.56:Swamps, Marshes (556.56) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647022998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Wetlands&rft.atitle=Diversity+of+Desulfobacteriaceae+and+Overall+Activity+of+Sulfate-Reducing+Microorganisms+in+and+Around+a+Salt+pan+in+a+Southern+California+Coastal+Wetland&rft.au=Jackson%2C+Karen+L%3BWhitcraft%2C+Christine+R%3BDillon%2C+Jesse+G&rft.aulast=Jackson&rft.aufirst=Karen&rft.date=2014-10-01&rft.volume=34&rft.issue=5&rft.spage=969&rft.isbn=&rft.btitle=&rft.title=Wetlands&rft.issn=02775212&rft_id=info:doi/10.1007%2Fs131570140560z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Sediment chemistry; Anaerobic respiration; Coastal zone; Salt marshes; Species diversity; Microorganisms; Decomposers; Wetlands; Diving physiology; Beaches; Sulfate-reducing bacteria; Sulfate reduction; Carbon cycle; Vegetation; Salinity tolerance; Genotypes; Habitat; Sediments; Salts; Carbon; Pans; Desulfobacteriaceae; INE, USA, California, Huntington Beach DO - http://dx.doi.org/10.1007/s131570140560z ER - TY - JOUR T1 - Prevalence of Chronic Obstructive Pulmonary Disease Among US Working Adults Aged 40 to 70 Years: National Health Interview Survey Data 2004 to 2011 AN - 1627961296; 20921234 AB - Objective: To estimate the prevalence and prevalence odds ratios of chronic obstructive pulmonary disease (COPD) among US workers by major occupational groups. Methods: The 2004 to 2011 National Health Interview Survey data for working adults 40 to 70 years old was analyzed to estimate the prevalence of COPD by major occupational groups. Logistic regression models were used to evaluate the associations between COPD (chronic bronchitis or emphysema) and occupations. Results: The estimated overall COPD prevalence was 4.2% (95% CI, 4.0 to 4.3). The odds of COPD were highest among workers in health care support occupations (prevalence odds ratio, 1.64; 95% CI, 1.25 to 2.14) followed by food preparation and serving-related occupations (prevalence odds ratio, 1.57; 95% CI, 1.20 to 2.06). Conclusions: Prevalence varied by occupations, suggesting workplace exposures may contribute to COPD. Preventive measures such as interventions to reduce smoking may reduce the prevalence of COPD. JF - Journal of Occupational and Environmental Medicine AU - Doney, Brent AU - Hnizdo, Eva AU - Syamlal, Girija AU - Kullman, Greg AU - Burchfiel, Cecil AU - Martin, Christopher J AU - Mujuru, Priscah AD - Division of Respiratory Disease Studies, Surveillance Branch, National Institute for Occupational Safety and Health, Mailstop HG 900.2, 1095 Willowdale Rd., Morgantown, WV 26505, bdoney@cdc.gov Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 1088 EP - 1093 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 56 IS - 10 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Smoking KW - Health care KW - Intervention KW - Occupational exposure KW - Chronic obstructive pulmonary disease KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627961296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Prevalence+of+Chronic+Obstructive+Pulmonary+Disease+Among+US+Working+Adults+Aged+40+to+70+Years%3A+National+Health+Interview+Survey+Data+2004+to+2011&rft.au=Doney%2C+Brent%3BHnizdo%2C+Eva%3BSyamlal%2C+Girija%3BKullman%2C+Greg%3BBurchfiel%2C+Cecil%3BMartin%2C+Christopher+J%3BMujuru%2C+Priscah&rft.aulast=Doney&rft.aufirst=Brent&rft.date=2014-10-01&rft.volume=56&rft.issue=10&rft.spage=1088&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000232 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Smoking; Health care; Intervention; Occupational exposure; Chronic obstructive pulmonary disease DO - http://dx.doi.org/10.1097/JOM.0000000000000232 ER - TY - JOUR T1 - Do Childhood Externalizing Disorders Predict Adult Depression? A Meta-Analysis AN - 1627730686 AB - Childhood externalizing disorders have been linked to adult affective disorders, although some studies fail to substantiate this finding. Multiple longitudinal cohort studies identifying childhood psychopathology and their association with adult psychiatric illness have been published. To examine the association between childhood externalizing symptoms or disorders and the development of adult depression across cohorts, a meta-analysis was performed. Potential studies were identified using a PubMed search through November 2013. All published, prospective, longitudinal, community-sampled cohort studies of children (≤ 13 years) with externalizing symptoms or disorders (aggression, conduct problems, oppositional defiant disorder, conduct disorder), reassessed in adulthood (≥ 18 years) for depressive disorders (major depressive disorder, depressive disorder NOS, or dysthymic disorder) were included. A random effects model was used to summarize the pooled effect sizes. Ancillary analyses considered covariates that could account for variance among studies. Ten studies representing eight cohorts of children initially assessed at age 13 or younger (N=17,712) were included in the meta-analysis. Childhood externalizing behavior was associated with adult depressive disorders (OR=1.52, 95 % confidence interval=1.27–1.80, p<0.0001). Utilizing Orwin’s Fail-safe N approach, 263 studies with a mean odds ratio of 1.0 would have to be added to the analysis before the cumulative effect would become trivial. Externalizing psychopathology in childhood is associated with the development of unipolar depressive disorders in adulthood. JF - Journal of Abnormal Child Psychology AU - Loth, Annemarie K AU - Drabick, Deborah A G AU - Leibenluft, Ellen AU - Hulvershorn, Leslie A AD - Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, 705 Riley Hospital Drive, Room 4300, Indianapolis, IN, 46202, USA lhulvers@iupui.edu lhulvers@iupui.edu; Department of Psychology, Temple University, Philadelphia, PA, USA ; Section on Bipolar Spectrum Disorders, Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA ; Department of Psychiatry, Indiana University School of Medicine, Riley Hospital for Children, 705 Riley Hospital Drive, Room 4300, Indianapolis, IN, 46202, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 1103 EP - 1113 CY - New York PB - Springer Science & Business Media VL - 42 IS - 7 SN - 0091-0627 KW - Medical Sciences--Physical Medicine And Rehabilitation KW - Predictors KW - Adults KW - Analysis KW - Adulthood KW - Affective disorders KW - Aggression KW - Childhood KW - Children KW - Cohort analysis KW - Conduct disorders KW - Depression KW - Depressive personality disorders KW - Externalizing behaviour KW - Externalizing problems KW - Oppositional defiant disorder KW - Psychopathology KW - Random effects KW - Symptoms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627730686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Child+Psychology&rft.atitle=Do+Childhood+Externalizing+Disorders+Predict+Adult+Depression%3F+A+Meta-Analysis&rft.au=Loth%2C+Annemarie+K%3BDrabick%2C+Deborah+A+G%3BLeibenluft%2C+Ellen%3BHulvershorn%2C+Leslie+A&rft.aulast=Loth&rft.aufirst=Annemarie&rft.date=2014-10-01&rft.volume=42&rft.issue=7&rft.spage=1103&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Child+Psychology&rft.issn=00910627&rft_id=info:doi/10.1007%2Fs10802-014-9867-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright Springer Science & Business Media Oct 2014 N1 - Date revised - 2014-11-10 N1 - Last updated - 2017-02-08 DO - http://dx.doi.org/10.1007/s10802-014-9867-8 ER - TY - JOUR T1 - Preferences for patient medication information: what do patients want? AN - 1625336814; 4618328 AB - This study investigated respondent preferences on how best to display patient medication information (PMI) that accompanies prescription medications to promote comprehension and appropriate usage. The authors identified 30 individuals diagnosed with select immune disorders, 30 with other chronic diseases, and 30 from the general public and had them review one of two PMI handouts that varied by format, organization, and content. The authors explored preferences for the PMI handout using one-on-one interviews. The authors analyzed the qualitative data to identify relevant themes and patterns using NVivo9 qualitative software. The majority of respondents noted that the formats of the two PMI handouts were more informative than those they currently receive from the pharmacist, with a preference for the 2-column, segmented design. However, respondent PMI preferences varied by age, education, and health status. Patients need simpler and more concise drug information to make better decisions about their health. Current PMI handouts are dense and complex, which can be confusing and not reader friendly. To improve PMI understandability and usefulness, the U.S. Food and Drug Administration is working with stakeholders, consumer advocates, and academics. Findings from this study may help inform future development of more user- friendly PMI. Reprinted by permission of Taylor & Francis Ltd. JF - Journal of health communication AU - Kish-Doto, Julia AU - Scales, Monica AU - Eguino-Medina, Paula AU - Fitzgerald, Tania AU - Tzeng, Janice P AU - McCormack, Lauren A AU - Donoghue, Amie O' AU - Oguntimein, Oluwamurewa AU - West, Suzanne L AD - RTI International ; US Food and Drug Administration Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 77 EP - 88 VL - 19 IS - Supp.2 SN - 1081-0730, 1081-0730 KW - Sociology KW - Qualitative analysis KW - Stakeholder KW - Preferences KW - Patients KW - Interviews KW - U.S.A. KW - Health inequality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1625336814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+communication&rft.atitle=Preferences+for+patient+medication+information%3A+what+do+patients+want%3F&rft.au=Kish-Doto%2C+Julia%3BScales%2C+Monica%3BEguino-Medina%2C+Paula%3BFitzgerald%2C+Tania%3BTzeng%2C+Janice+P%3BMcCormack%2C+Lauren+A%3BDonoghue%2C+Amie+O%27%3BOguntimein%2C+Oluwamurewa%3BWest%2C+Suzanne+L&rft.aulast=Kish-Doto&rft.aufirst=Julia&rft.date=2014-10-01&rft.volume=19&rft.issue=Supp.2&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+communication&rft.issn=10810730&rft_id=info:doi/10.1080%2F10810730.2014.946114 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-11-17 N1 - Last updated - 2014-11-17 N1 - SubjectsTermNotLitGenreText - 9271 7890 5792 10484; 10016; 6832 10919; 12158; 10519 3279 971 3286; 5783 5772 6489; 433 293 14 DO - http://dx.doi.org/10.1080/10810730.2014.946114 ER - TY - JOUR T1 - Highlights from the United States Food and Drug Administration's public workshop on the development of animal models of pregnancy to address medical countermeasures in an "at-risk" population of pregnant women: Influenza as a case study AN - 1622613645; 20886899 AB - The U.S. Food and Drug Administration (FDA) and other federal agencies partner to ensure that medical countermeasures (e.g., drug therapies and vaccines) are available for public health emergencies (FDA, 2014). Despite continuing progress, providing medical countermeasures and treatment guidelines for certain populations (e.g., pregnant women) is challenging due to the lack of clinical and/or animal data. Thus, a workshop was convened to discuss animal models of pregnancy for the evaluation of disease progression and medical countermeasures. Birth Defects Research (Part A) 100:806-810, 2014. copyright 2014 Wiley Periodicals, Inc. JF - Birth Defects Research Part A: Clinical and Molecular Teratology AU - Williams, Denita AU - Basavarajappa, Mallikarjuna S AU - Rasmussen, Sonja A AU - Morris, Suzanne AU - Mattison, Donald AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 806 EP - 810 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 100 IS - 10 SN - 1542-0752, 1542-0752 KW - Virology & AIDS Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Data processing KW - Conferences KW - Guidelines KW - Animal models KW - Drug development KW - Pregnancy KW - Public health KW - Influenza KW - USA KW - Case studies KW - FDA KW - Congenital defects KW - Females KW - Vaccines KW - Drugs KW - V 22410:Animal Diseases KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622613645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.atitle=Highlights+from+the+United+States+Food+and+Drug+Administration%27s+public+workshop+on+the+development+of+animal+models+of+pregnancy+to+address+medical+countermeasures+in+an+%22at-risk%22+population+of+pregnant+women%3A+Influenza+as+a+case+study&rft.au=Williams%2C+Denita%3BBasavarajappa%2C+Mallikarjuna+S%3BRasmussen%2C+Sonja+A%3BMorris%2C+Suzanne%3BMattison%2C+Donald&rft.aulast=Williams&rft.aufirst=Denita&rft.date=2014-10-01&rft.volume=100&rft.issue=10&rft.spage=806&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+A%3A+Clinical+and+Molecular+Teratology&rft.issn=15420752&rft_id=info:doi/10.1002%2Fbdra.23319 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Influenza; Data processing; Conferences; Animal models; Congenital defects; Drug development; Vaccines; Public health; Pregnancy; Case studies; Guidelines; FDA; Females; Drugs; USA DO - http://dx.doi.org/10.1002/bdra.23319 ER - TY - JOUR T1 - Combined effect of hyperuricemia and overweight/obesity on the prevalence of hypertension among US adults: result from the National Health and Nutrition Examination Survey AN - 1622611649; 20867438 AB - Hypertension is a large and growing public health problem worldwide. Hyperuricemia and overweight/obesity are two of the most important risk factors for hypertension. However, their combined effect on the risk of hypertension is not known. Participants aged 20 years and older from the National Health and Nutrition Examination Survey from 1999-2012 were used to evaluate the separate and combined effects of hyperuricemia and overweight/obesity on the risk of prevalent hypertension among different race, gender and age groups. Participants (31 473) were used to estimate separate and combined effects on the prevalence of hypertension. The overall prevalence of hypertension among adults with a combination of hyperuricemia and overweight/obesity (50.2%, 95% confidence interval (CI) 48.3-52.1%) was significantly higher than separate hyperuricemia (41.7%, 95% CI 37.2-46.2%) and overweight/obesity (30.6%, 95% CI 29.5-31.8%). The magnitude of odds ratio (OR) from the combination of hyperuricemia and overweight/obesity (OR=4.53, 95% CI 4.05-5.07) was significantly higher than both hyperuricemia (OR=2.62, 95% CI 2.07-3.32) and overweight/obesity (OR=2.08, 95% CI 1.89-2.30). Combined effect of hyperuricemia and overweight/obesity on the risk of hypertension is much stronger than any separate one. These data can provide important information for identification of target populations for future intervention and patient management. JF - Journal of Human Hypertension AU - Han, G-M AU - Gonzalez, S AU - DeVries, D AD - 1] Department of Epidemiology, University of Nebraska Medical Center, Omaha, NE, USA [2] Nebraska Department of Health and Human Services, Lincoln, NE, USA Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 579 EP - 586 PB - Nature Publishing Group VL - 28 IS - 10 SN - 0950-9240, 0950-9240 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Obesity KW - Risk factors KW - Gender KW - Intervention KW - Age groups KW - Nutrition KW - Hypertension KW - Public health KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622611649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Human+Hypertension&rft.atitle=Combined+effect+of+hyperuricemia+and+overweight%2Fobesity+on+the+prevalence+of+hypertension+among+US+adults%3A+result+from+the+National+Health+and+Nutrition+Examination+Survey&rft.au=Han%2C+G-M%3BGonzalez%2C+S%3BDeVries%2C+D&rft.aulast=Han&rft.aufirst=G-M&rft.date=2014-10-01&rft.volume=28&rft.issue=10&rft.spage=579&rft.isbn=&rft.btitle=&rft.title=Journal+of+Human+Hypertension&rft.issn=09509240&rft_id=info:doi/10.1038%2Fjhh.2014.31 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - Obesity; Risk factors; Gender; Intervention; Age groups; Nutrition; Public health; Hypertension DO - http://dx.doi.org/10.1038/jhh.2014.31 ER - TY - JOUR T1 - Intranasal Administration of Mycobacterium bovis BCG Induces Superior Protection against Aerosol Infection with Mycobacterium tuberculosis in Mice AN - 1622603475; 20856153 AB - Despite the widespread use of Mycobacterium bovis BCG, the only licensed vaccine against tuberculosis (TB), TB remains a global epidemic. To assess whether more direct targeting of the lung mucosa by respiratory immunization would enhance the potency and longevity of BCG-induced anti-TB protective immunity, the long-term impact of intranasal (i.n.) BCG vaccination was compared to conventional subcutaneous (s.c.) immunization by using a mouse model of pulmonary tuberculosis. Although significantly improved protection in the lung was seen at early time points (2 and 4 months postvaccination) in i.n. BCG-immunized mice, no differences in pulmonary protection were seen 8 and 10 months postvaccination. In contrast, in all of the study periods, i.n. BCG vaccination induced significantly elevated protective splenic responses relative to s.c. immunization. At five of nine time points, we observed a splenic protective response exceeding 1.9 log10 protection relative to the s.c. route. Furthermore, higher frequencies of CD4 T cells expressing gamma interferon (IFN- gamma ) and IFN- gamma /tumor necrosis factor alpha, as well as CD8 T cells expressing IFN- gamma , were detected in the spleens of i.n. vaccinated mice. Using PCR arrays, significantly elevated levels of IFN- gamma , interleukin-9 (IL-9), IL-11, and IL-21 expression were also seen in the spleen at 8 months after respiratory BCG immunization. Overall, while i.n. BCG vaccination provided short-term enhancement of protection in the lung relative to s.c. immunization, potent and extremely persistent splenic protective responses were seen for at least 10 months following respiratory immunization. JF - Clinical and Vaccine Immunology AU - Derrick, Steven C AU - Kolibab, Kristopher AU - Yang, Amy AU - Morris, Sheldon L Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 1443 EP - 1451 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 21 IS - 10 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Mucosa KW - Animal models KW - Infection KW - Interleukin 9 KW - Interleukin 11 KW - CD4 antigen KW - Intranasal administration KW - Lymphocytes T KW - Polymerase chain reaction KW - Tuberculosis KW - Aerosols KW - Epidemics KW - Spleen KW - Mycobacterium bovis KW - CD8 antigen KW - Immunity KW - Interleukin 21 KW - Vaccination KW - Longevity KW - Lung KW - BCG KW - Tumor necrosis factor- alpha KW - Vaccines KW - Mycobacterium tuberculosis KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622603475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Intranasal+Administration+of+Mycobacterium+bovis+BCG+Induces+Superior+Protection+against+Aerosol+Infection+with+Mycobacterium+tuberculosis+in+Mice&rft.au=Derrick%2C+Steven+C%3BKolibab%2C+Kristopher%3BYang%2C+Amy%3BMorris%2C+Sheldon+L&rft.aulast=Derrick&rft.aufirst=Steven&rft.date=2014-10-01&rft.volume=21&rft.issue=10&rft.spage=1443&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00394-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Number of references - 36 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Aerosols; Epidemics; Mucosa; Animal models; Spleen; Immunity; CD8 antigen; Interleukin 21; Infection; Vaccination; Longevity; Interleukin 9; Interleukin 11; CD4 antigen; Intranasal administration; BCG; Lung; Lymphocytes T; Polymerase chain reaction; Tuberculosis; Vaccines; Tumor necrosis factor- alpha; Mycobacterium bovis; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/CVI.00394-14 ER - TY - JOUR T1 - In vitroinvestigation of the mutagenic potential of Aloe veraextracts AN - 1618160829; 20853696 AB - A 2-year cancer bioassay in rodents with a preparation of Aloe verawhole leaf extract administered in drinking water showed clear evidence of carcinogenic activity. To provide insight into the identity and mechanisms associated with mutagenic components of the Aloe veraextracts, we used the mouse lymphoma assay to evaluate the mutagenicity of the Aloe verawhole leaf extract (WLE) and Aloe veradecolorized whole leaf extract (WLD). The WLD extract was obtained by subjecting WLE to activated carbon-adsorption. HPLC analysis indicated that the decolorization process removed many components from the WLE extract, including anthraquinones. Both WLE and WLD extracts showed cytotoxic and mutagenic effects in mouse lymphoma cells but in different concentration ranges, and WLD induced about 3-fold higher levels of intracellular reactive oxygen species than WLE. Molecular analysis of mutant colonies from cells treated with WLE and WLD revealed that the primary type of damage from both treatments was largely due to chromosome mutations (deletions and/or mitotic recombination). The fact that the samples were mutagenic at different concentrations suggests that while some mutagenic components of WLE were removed by activated carbon filtration, components with pro-oxidant activity and mutagenic activity remained. The results demonstrate the utility of the mouse lymphoma assay as a tool to characterize the mutagenic activity of fractionated complex botanical mixtures to identify bioactive components. JF - Toxicology Research AU - Guo, Xiaoqing AU - Zhang, Suhui AU - Dial, Stacey L AU - Boudreau, Mary D AU - Xia, Qingsu AU - Fu, Peter P AU - Levy, Dan D AU - Moore, Martha M AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology; National Center for Toxicological Research; Jefferson; AR 72079; USA; +1 (870) 543-7386; , Nan.Mei@fda.hhs.gov Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 487 EP - 496 PB - Royal Society of Chemistry, c/o Springer-Verlag New York Inc. Secaucus New Jersey 07096 2485 United States VL - 3 IS - 6 SN - 2045-452X, 2045-452X KW - Toxicology Abstracts KW - High-performance liquid chromatography KW - Mutagenicity KW - Aloe KW - anthraquinone KW - Leaves KW - Carbon (activated) KW - Cancer KW - Wld protein KW - Recombination KW - Cytotoxicity KW - Chromosomes KW - Filtration KW - Colonies KW - Reactive oxygen species KW - Chromosome deletion KW - Drinking water KW - Lymphoma KW - Mutation KW - decolorization KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1618160829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+Research&rft.atitle=In+vitroinvestigation+of+the+mutagenic+potential+of+Aloe+veraextracts&rft.au=Guo%2C+Xiaoqing%3BZhang%2C+Suhui%3BDial%2C+Stacey+L%3BBoudreau%2C+Mary+D%3BXia%2C+Qingsu%3BFu%2C+Peter+P%3BLevy%2C+Dan+D%3BMoore%2C+Martha+M%3BMei%2C+Nan&rft.aulast=Guo&rft.aufirst=Xiaoqing&rft.date=2014-10-01&rft.volume=3&rft.issue=6&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Toxicology+Research&rft.issn=2045452X&rft_id=info:doi/10.1039%2Fc4tx00053f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-01 N1 - Number of references - 44 N1 - Last updated - 2015-08-05 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Mutagenicity; anthraquinone; Leaves; Carbon (activated); Wld protein; Cancer; Recombination; Colonies; Filtration; Chromosomes; Cytotoxicity; Reactive oxygen species; Chromosome deletion; Drinking water; Mutation; Lymphoma; decolorization; Aloe DO - http://dx.doi.org/10.1039/c4tx00053f ER - TY - JOUR T1 - Structural determinants for binding, activation, and functional selectivity of the angiotensin AT1 receptor. AN - 1612288569; 25013233 AB - The renin-angiotensin system (RAS) plays an important role in the pathophysiology of cardiovascular disorders. Pharmacologic interventions targeting the RAS cascade have led to the discovery of renin inhibitors, angiotensin-converting enzyme inhibitors, and AT(1) receptor blockers (ARBs) to treat hypertension and some cardiovascular and renal disorders. Mutagenesis and modeling studies have revealed that differential functional outcomes are the results of multiple active states conformed by the AT(1) receptor upon interaction with angiotensin II (Ang II). The binding of agonist is dependent on both extracellular and intramembrane regions of the receptor molecule, and as a consequence occupies more extensive area of the receptor than a non-peptide antagonist. Both agonist and antagonist bind to the same intramembrane regions to interfere with each other's binding to exhibit competitive, surmountable interaction. The nature of interactions with the amino acids in the receptor is different for each of the ARBs given the small differences in the molecular structure between drugs. AT(1) receptors attain different conformation states after binding various Ang II analogues, resulting in variable responses through activation of multiple signaling pathways. These include both classical and non-classical pathways mediated through growth factor receptor transactivations, and provide cross-communication between downstream signaling molecules. The structural requirements for AT(1) receptors to activate extracellular signal-regulated kinases 1 and 2 through G proteins, or G protein-independently through β-arrestin, are different. We review the structural and functional characteristics of Ang II and its analogs and antagonists, and their interaction with amino acid residues in the AT(1) receptor. © 2014 Society for Endocrinology. JF - Journal of molecular endocrinology AU - Balakumar, Pitchai AU - Jagadeesh, Gowraganahalli AD - Pharmacology UnitFaculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, MalaysiaDivision of Cardiovascular and Renal ProductsCenter for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA pbala2006@gmail.com. ; Pharmacology UnitFaculty of Pharmacy, AIMST University, Semeling, 08100 Bedong, Kedah Darul Aman, MalaysiaDivision of Cardiovascular and Renal ProductsCenter for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland 20993, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - R71 EP - R92 VL - 53 IS - 2 KW - Amino Acids KW - 0 KW - Angiotensin II Type 1 Receptor Blockers KW - Ligands KW - Receptor, Angiotensin, Type 1 KW - Angiotensin II KW - 11128-99-7 KW - Index Medicus KW - angiotensin II KW - renin–angiotensin system KW - AT1 receptor KW - β-arrestin KW - Animals KW - Angiotensin II -- metabolism KW - Humans KW - Angiotensin II Type 1 Receptor Blockers -- pharmacology KW - Protein Interaction Domains and Motifs KW - Protein Binding KW - Signal Transduction KW - Receptor, Angiotensin, Type 1 -- genetics KW - Receptor, Angiotensin, Type 1 -- chemistry KW - Receptor, Angiotensin, Type 1 -- agonists KW - Receptor, Angiotensin, Type 1 -- metabolism KW - Binding Sites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1612288569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+endocrinology&rft.atitle=Structural+determinants+for+binding%2C+activation%2C+and+functional+selectivity+of+the+angiotensin+AT1+receptor.&rft.au=Balakumar%2C+Pitchai%3BJagadeesh%2C+Gowraganahalli&rft.aulast=Balakumar&rft.aufirst=Pitchai&rft.date=2014-10-01&rft.volume=53&rft.issue=2&rft.spage=R71&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+endocrinology&rft.issn=1479-6813&rft_id=info:doi/10.1530%2FJME-14-0125 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-22 N1 - Date created - 2014-09-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1530/JME-14-0125 ER - TY - JOUR T1 - Methamphetamine-induced toxicity: an updated review on issues related to hyperthermia. AN - 1612287732; 24836729 AB - Reports of methamphetamine-related emergency room visits suggest that elevated body temperature is a universal presenting symptom, with lethal overdoses generally associated with extreme hyperthermia. This review summarizes the available information on methamphetamine toxicity as it pertains to elevations in body temperature. First, a brief overview of thermoregulatory mechanisms is presented. Next, central and peripheral targets that have been considered for potential involvement in methamphetamine hyperthermia are discussed. Finally, future areas of investigation are proposed, as further studies are needed to provide greater insight into the mechanisms that mediate the alterations in body temperature elicited by methamphetamine. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Pharmacology & therapeutics AU - Matsumoto, Rae R AU - Seminerio, Michael J AU - Turner, Ryan C AU - Robson, Matthew J AU - Nguyen, Linda AU - Miller, Diane B AU - O'Callaghan, James P AD - Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA. Electronic address: rmatsumoto@hsc.wvu.edu. ; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Department of Medicine, University of Chicago, Chicago, IL 60637, USA. ; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA; Department of Neurosurgery, School of Medicine, West Virginia University, Morgantown, WV 26506,USA. ; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Department of Pharmacology, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA. ; Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA; Center for Neuroscience, School of Medicine, West Virginia University, Morgantown, WV 26506, USA. ; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 28 EP - 40 VL - 144 IS - 1 KW - Central Nervous System Stimulants KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Hyperthermia KW - Autonomic nervous system KW - Reactive oxygen species KW - Thermoregulation KW - Toxicity KW - Body Temperature Regulation -- drug effects KW - Animals KW - Body Temperature -- drug effects KW - Humans KW - Drug Overdose KW - Fever -- chemically induced KW - Methamphetamine -- adverse effects KW - Central Nervous System Stimulants -- adverse effects KW - Methamphetamine -- poisoning KW - Central Nervous System Stimulants -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1612287732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+therapeutics&rft.atitle=Methamphetamine-induced+toxicity%3A+an+updated+review+on+issues+related+to+hyperthermia.&rft.au=Matsumoto%2C+Rae+R%3BSeminerio%2C+Michael+J%3BTurner%2C+Ryan+C%3BRobson%2C+Matthew+J%3BNguyen%2C+Linda%3BMiller%2C+Diane+B%3BO%27Callaghan%2C+James+P&rft.aulast=Matsumoto&rft.aufirst=Rae&rft.date=2014-10-01&rft.volume=144&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+therapeutics&rft.issn=1879-016X&rft_id=info:doi/10.1016%2Fj.pharmthera.2014.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-12 N1 - Date created - 2014-08-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurochem. 2010 Nov;115(3):595-605 [20722968] Front Biosci (Landmark Ed). 2011;16:74-104 [21196160] 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Toxicol (Phila). 2010 Aug;48(7):675-94 [20849327] Drug Alcohol Depend. 2010 Oct 1;111(3):241-9 [20541333] Am J Physiol. 1995 Apr;268(4 Pt 2):R838-50 [7733392] Psychopharmacology (Berl). 1995 Apr;118(3):267-72 [7617818] J Pharmacol Exp Ther. 1995 Dec;275(3):1104-14 [8531070] Neuropsychopharmacology. 1995 Oct;13(2):105-15 [8597522] Eur J Pharmacol. 1995 Dec 29;294(2-3):721-6 [8750738] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.pharmthera.2014.05.001 ER - TY - JOUR T1 - MicroRNA-155 deficient mice experience heightened kidney toxicity when dosed with cisplatin. AN - 1609309303; 25015656 AB - The development of nephrotoxicity limits the maximum achievable dosage and treatment intervals for cisplatin chemotherapy. Therefore, identifying mechanisms that regulate this toxicity could offer novel methods to optimize cisplatin delivery. MicroRNAs are capable of regulating many different genes, and can influence diverse cellular processes, including cell death and apoptosis. We previously observed miR-155 to be highly increased following ischemic or toxic injury to the kidneys and, therefore, sought to determine whether mice deficient in miR-155 would respond differently to kidney injury. We treated C57BL/6 and miR-155(-/-) mice with 20 mg/kg of cisplatin and found a significantly higher level of kidney injury in the miR-155(-/-) mice. Genome-wide expression profiling and bioinformatic analysis indicated the activation of a number of canonical signaling pathways relating to apoptosis and oxidative stress over the course of the injury, and identified potential upstream regulators of these effects. One predicted upstream regulator was c-Fos, which has two confirmed miR-155 binding sites in its 3' UTR and, therefore, can be directly regulated by miR-155. We established that the miR-155(-/-) mice had significantly higher levels of c-Fos mRNA and protein than the C57BL/6 mice at 72 h after cisplatin exposure. These data indicate a role for miR-155 in the cisplatin response and suggest that targeting of c-Fos could be investigated to reduce cisplatin-induced nephrotoxicity. © The Author 2014. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oup.com. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Pellegrini, Kathryn L AU - Han, Tao AU - Bijol, Vanesa AU - Saikumar, Janani AU - Craciun, Florin L AU - Chen, William W AU - Fuscoe, James C AU - Vaidya, Vishal S AD - Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. ; Division of Systems Biology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. ; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. ; Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, Massachusetts. ; Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts Laboratory of Systems Pharmacology, Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, Massachusetts Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts vvaidya@partners.org. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 484 EP - 492 VL - 141 IS - 2 KW - MicroRNAs KW - 0 KW - Mirn155 microRNA, mouse KW - Proto-Oncogene Proteins c-fos KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - microRNA-155 KW - Kidney toxicity KW - cisplatin KW - miRNAs KW - Animals KW - Proto-Oncogene Proteins c-fos -- metabolism KW - Fibrosis KW - Disease Models, Animal KW - Oxidative Stress -- genetics KW - Computational Biology KW - Gene Expression Profiling -- methods KW - Mice, Knockout KW - Apoptosis -- genetics KW - Proto-Oncogene Proteins c-fos -- genetics KW - Signal Transduction -- genetics KW - Mice, Inbred C57BL KW - Up-Regulation KW - Time Factors KW - Male KW - Kidney -- metabolism KW - Acute Kidney Injury -- genetics KW - MicroRNAs -- metabolism KW - Kidney -- pathology KW - MicroRNAs -- genetics KW - Acute Kidney Injury -- pathology KW - Acute Kidney Injury -- chemically induced KW - Acute Kidney Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609309303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=MicroRNA-155+deficient+mice+experience+heightened+kidney+toxicity+when+dosed+with+cisplatin.&rft.au=Pellegrini%2C+Kathryn+L%3BHan%2C+Tao%3BBijol%2C+Vanesa%3BSaikumar%2C+Janani%3BCraciun%2C+Florin+L%3BChen%2C+William+W%3BFuscoe%2C+James+C%3BVaidya%2C+Vishal+S&rft.aulast=Pellegrini&rft.aufirst=Kathryn&rft.date=2014-10-01&rft.volume=141&rft.issue=2&rft.spage=484&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu143 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-11-02 N1 - Date created - 2014-10-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Sci. 2012 Oct;129(2):256-67 [22705808] Am J Pathol. 2012 Sep;181(3):818-28 [22819533] Cancer Gene Ther. 2012 Nov;19(11):773-8 [22996741] J Am Soc Nephrol. 2013 Dec;24(12):1955-65 [23949802] Cell. 2001 Jan 12;104(1):21-32 [11163237] Environ Health Perspect. 2003 Nov;111(15):1819-26 [14630514] Nat Rev Cancer. 2003 Nov;3(11):859-68 [14668816] Cancer Cell. 2003 Dec;4(6):477-82 [14706339] J Biol Chem. 2004 Jun 11;279(24):25313-9 [15078869] Mol Cell Biol. 1996 Jan;16(1):211-8 [8524298] Nat Rev Drug Discov. 2005 Apr;4(4):307-20 [15789122] Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61 [16461460] Science. 2007 Apr 27;316(5824):604-8 [17463289] Cancer Res. 2007 Oct 1;67(19):9425-34 [17909052] Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16170-5 [17911264] Nucleic Acids Res. 2008 Jan;36(Database issue):D149-53 [18158296] Kidney Int. 2008 May;73(9):994-1007 [18272962] Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2735-40 [19193853] Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5330-5 [19289845] Toxicol In Vitro. 2009 Aug;23(5):780-8 [19383537] Methods Mol Biol. 2009;563:379-98 [19597796] Urology. 2010 Apr;75(4):835-41 [20035975] J Biol Chem. 2010 Jun 4;285(23):17869-79 [20371610] Genome Biol. 2010;11(8):R90 [20799968] Blood. 2011 Apr 28;117(17):4490-500 [21385848] FEBS J. 2011 Jun;278(11):1873-81 [21439021] Dis Markers. 2011;30(4):171-9 [21694443] Blood. 2011 Aug 18;118(7):1934-42 [21685370] Mol Med Rep. 2012 Apr;5(4):949-54 [22307849] Proc Natl Acad Sci U S A. 2012 May 8;109(19):E1153-62 [22509021] Biochem Soc Trans. 2012 Aug;40(4):821-5 [22817741] PLoS One. 2012;7(9):e45628 [23029147] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu143 ER - TY - JOUR T1 - FDA approval summary: crizotinib for the treatment of metastatic non-small cell lung cancer with anaplastic lymphoma kinase rearrangements. AN - 1609306303; 25170012 AB - On August 26, 2011, crizotinib received accelerated approval for the treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) that is ALK-positive as detected by a test approved by the U.S. Food and Drug Administration (FDA). Approval was based on two single-arm trials demonstrating objective response rates (ORRs) of 50% and 61% and median response durations of 42 and 48 weeks. On November 20, 2013, crizotinib received regular approval based on confirmation of clinical benefit in study A8081007, a randomized trial in 347 patients with ALK-positive advanced NSCLC who had previously received one platinum-containing regimen. Patients were assigned (1:1) to receive crizotinib 250 mg orally twice daily or standard of care (docetaxel or pemetrexed). The primary endpoint was progression-free survival (PFS) determined by independent radiology review; secondary endpoints were ORR and overall survival (OS). PFS was significantly longer in the crizotinib arm, with median PFS of 7.7 and 3.0 months in the crizotinib and chemotherapy arms, respectively, and a 46% absolute increase in ORR but no difference in OS between treatment arms at the interim analysis. The most common adverse drug reactions (>25%) in crizotinib-treated patients were vision disorders, nausea, diarrhea, vomiting, constipation, edema, elevated transaminases, and fatigue. The most serious toxicities of crizotinib were hepatotoxicity, interstitial lung disease or pneumonitis, and QT-interval prolongation. Crizotinib's rapid clinical development program (6 years from identification of ALK rearrangements in a subset of NSCLC to full FDA approval) is a model of efficient drug development in this new era of molecularly targeted oncology therapy. ©AlphaMed Press. JF - The oncologist AU - Kazandjian, Dickran AU - Blumenthal, Gideon M AU - Chen, Huan-Yu AU - He, Kun AU - Patel, Mona AU - Justice, Robert AU - Keegan, Patricia AU - Pazdur, Richard AD - Office of Hematology and Oncology Products and Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA Dickran.kazandjian@fda.hhs.gov. ; Office of Hematology and Oncology Products and Office of Biostatistics, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - e5 EP - 11 VL - 19 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Protein Kinase Inhibitors KW - Pyrazoles KW - Pyridines KW - Taxoids KW - Pemetrexed KW - 04Q9AIZ7NO KW - docetaxel KW - 15H5577CQD KW - crizotinib KW - 53AH36668S KW - Receptor Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - anaplastic lymphoma kinase KW - Index Medicus KW - Molecular targeted therapy KW - EML4-ALK fusion protein KW - Non-small cell lung carcinoma KW - Neoplasm metastasis KW - Crizotinib KW - United States KW - Young Adult KW - United States Food and Drug Administration KW - Aged, 80 and over KW - Humans KW - Drug Approval KW - Adult KW - Treatment Outcome KW - Pemetrexed -- therapeutic use KW - Neoplasm Metastasis KW - Aged KW - Middle Aged KW - Taxoids -- therapeutic use KW - Male KW - Female KW - Receptor Protein-Tyrosine Kinases -- genetics KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- drug therapy KW - Pyrazoles -- adverse effects KW - Pyrazoles -- therapeutic use KW - Pyridines -- therapeutic use KW - Antineoplastic Agents -- adverse effects KW - Protein Kinase Inhibitors -- therapeutic use KW - Protein Kinase Inhibitors -- adverse effects KW - Lung Neoplasms -- genetics KW - Antineoplastic Agents -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Pyridines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1609306303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+oncologist&rft.atitle=FDA+approval+summary%3A+crizotinib+for+the+treatment+of+metastatic+non-small+cell+lung+cancer+with+anaplastic+lymphoma+kinase+rearrangements.&rft.au=Kazandjian%2C+Dickran%3BBlumenthal%2C+Gideon+M%3BChen%2C+Huan-Yu%3BHe%2C+Kun%3BPatel%2C+Mona%3BJustice%2C+Robert%3BKeegan%2C+Patricia%3BPazdur%2C+Richard&rft.aulast=Kazandjian&rft.aufirst=Dickran&rft.date=2014-10-01&rft.volume=19&rft.issue=10&rft.spage=e5&rft.isbn=&rft.btitle=&rft.title=The+oncologist&rft.issn=1549-490X&rft_id=info:doi/10.1634%2Ftheoncologist.2014-0241 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-14 N1 - Date created - 2014-10-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Lancet Oncol. 2011 Aug;12(8):735-42 [21783417] J Thorac Oncol. 2011 Sep;6(9):1474-80 [21642865] CA Cancer J Clin. 2013 Jan;63(1):11-30 [23335087] J Clin Oncol. 2013 Mar 10;31(8):1105-11 [23401436] J Clin Oncol. 2013 Mar 10;31(8):981-3 [23401450] N Engl J Med. 2013 Jun 20;368(25):2385-94 [23724913] CA Cancer J Clin. 2014 Jan-Feb;64(1):9-29 [24399786] Nat Biotechnol. 2014 Apr;32(4):323-30 [24714478] Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22 [18089725] Nature. 2007 Aug 2;448(7153):561-6 [17625570] Science. 1994 Mar 4;263(5151):1281-4 [8122112] Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11 [15329413] Health Aff (Millwood). 2011 Jul;30(7):1375-81 [21680577] J Thorac Oncol. 2011 Apr;6(4):774-80 [21336183] Lancet Oncol. 2011 Feb;12(2):175-80 [21277552] Clin Cancer Res. 2014 Apr 15;20(8):2029-34 [24573551] Nat Rev Clin Oncol. 2009 Jun;6(6):352-66 [19483740] J Clin Oncol. 2004 May 1;22(9):1589-97 [15117980] N Engl J Med. 2010 Oct 28;363(18):1693-703 [20979469] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1634/theoncologist.2014-0241 ER - TY - JOUR T1 - Injury rates on new and old technology oil and gas rigs operated by the largest United States onshore drilling contractor AN - 1566839968; 20720184 AB - Background Occupational fatality rates among oil and gas extraction industry and specifically among drilling contractor workers are high compared to the U.S. all-industry average. There is scant literature focused on non-fatal injuries among drilling contractors, some of which have introduced engineering controls to improve rig efficiency and reduce injury risk. Methods We compared injury rates on new and old technology rigs operated by the largest U.S. drilling contractor during 2003-2012, stratifying by job type and grouping outcomes by injury severity and body part affected. Results Six hundred seventy-one injuries were recorded over 77.4 million person-hours. The rate on new rigs was 66% of that on old rigs. Roughnecks had lower injury rates on new rigs, largely through reduced limb injury rates. New rigs had lower rates in each non-fatal injury severity category. Conclusions For this company, new technology rigs appear to provide a safer environment for roughnecks. Future studies could include data from additional companies. Am. J. Ind. Med. 57:1188-1192, 2014. copyright 2014 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Blackley, David J AU - Retzer, Kyla D AU - Hubler, Warren G AU - Hill, Ryan D AU - Laney, AScott AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 1188 EP - 1192 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 10 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Health risks KW - Mortality KW - USA KW - Injuries KW - Contracts KW - Oil and gas industry KW - Technology KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566839968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Injury+rates+on+new+and+old+technology+oil+and+gas+rigs+operated+by+the+largest+United+States+onshore+drilling+contractor&rft.au=Blackley%2C+David+J%3BRetzer%2C+Kyla+D%3BHubler%2C+Warren+G%3BHill%2C+Ryan+D%3BLaney%2C+AScott&rft.aulast=Blackley&rft.aufirst=David&rft.date=2014-10-01&rft.volume=57&rft.issue=10&rft.spage=1188&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22356 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - Mortality; Health risks; Contracts; Injuries; Oil and gas industry; Technology; USA DO - http://dx.doi.org/10.1002/ajim.22356 ER - TY - JOUR T1 - Recombinant Deamidated Mutants of Erwinia chrysanthemi l-Asparaginase Have Similar or Increased Activity Compared to Wild-Type Enzyme AN - 1566832830; 20705463 AB - The enzyme Erwinia chrysanthemi l-asparaginase (ErA) is an important biopharmaceutical product used in the treatment of acute lymphoblastic leukaemia. Like all proteins, certain asparagine (Asn) residues of ErA are susceptible to deamidation to aspartic acid (Asp), which may be a concern with respect to enzyme activity and potentially to pharmaceutical efficacy. Recombinant ErA mutants containing Asn to Asp changes were expressed, purified and characterised. Two mutants with single deamidation sites (N41D and N281D) were found to have approximately the same specific activity (1,062 and 924 U/mg, respectively) as the wild-type (908 U/mg). However, a double mutant (N41D N281D) had an increased specific activity (1261 U/mg). The N41D mutation conferred a slight increase in the catalytic constant (k sub(cat) 657 s super(-1)) when compared to the WT (k sub(cat) 565 s super(-1)), which was further increased in the double mutant, with a k sub(cat) of 798 s super(-1). Structural analyses showed that the slight changes caused by point mutation of Asn sub(41) to Asp may have reduced the number of hydrogen bonds in this alpha -helical part of the protein structure, resulting in subtle changes in enzyme turnover, both structurally and catalytically. The increased alpha -helical content observed with the N41D mutation by circular dichroism spectroscopy correlates with the difference in k sub(cat), but not K sub(m). The N281D mutation resulted in a lower glutaminase activity compared with WT and the N41D mutant, however the N281D mutation also imparted less stability to the enzyme at elevated temperatures. Taken as a whole, these data suggest that ErA deamidation at the Asn sub(41) and Asn sub(281) sites does not affect enzyme activity and should not be a concern during processing, storage or clinical use. The production of recombinant deamidated variants has proven an effective and powerful means of studying the effect of these changes and may be a useful strategy for other biopharmaceutical products. JF - Molecular Biotechnology AU - Gervais, David AU - Foote, Nicholas AD - Microbiology Services, Development & Production, Public Health England, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK, dave.gervais@phe.gov.uk Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 865 EP - 877 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 56 IS - 10 SN - 1073-6085, 1073-6085 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Aspartic acid KW - Data processing KW - Point mutation KW - Enzymes KW - L-asparaginase KW - Spectroscopy KW - Asparagine KW - Protein structure KW - Hydrogen bonding KW - C.D. KW - Acute lymphatic leukemia KW - Glutaminase KW - Erwinia chrysanthemi KW - Pharmaceuticals KW - J 02410:Animal Diseases KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566832830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Biotechnology&rft.atitle=Recombinant+Deamidated+Mutants+of+Erwinia+chrysanthemi+l-Asparaginase+Have+Similar+or+Increased+Activity+Compared+to+Wild-Type+Enzyme&rft.au=Gervais%2C+David%3BFoote%2C+Nicholas&rft.aulast=Gervais&rft.aufirst=David&rft.date=2014-10-01&rft.volume=56&rft.issue=10&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Molecular+Biotechnology&rft.issn=10736085&rft_id=info:doi/10.1007%2Fs12033-014-9766-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 55 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Temperature effects; Data processing; Aspartic acid; Point mutation; Enzymes; L-asparaginase; Spectroscopy; Asparagine; Protein structure; Hydrogen bonding; Glutaminase; Acute lymphatic leukemia; C.D.; Pharmaceuticals; Erwinia chrysanthemi DO - http://dx.doi.org/10.1007/s12033-014-9766-9 ER - TY - JOUR T1 - Development and characterization of a resistance spot welding aerosol generator and inhalation exposure system. AN - 1566822610; 25140455 AB - Limited information exists regarding the health risks associated with inhaling aerosols that are generated during resistance spot welding of metals treated with adhesives. Toxicology studies evaluating spot welding aerosols are non-existent. A resistance spot welding aerosol generator and inhalation exposure system was developed. The system was designed by directing strips of sheet metal that were treated with an adhesive to two electrodes of a spot welder. Spot welds were made at a specified distance from each other by a computer-controlled welding gun in a fume collection chamber. Different target aerosol concentrations were maintained within the exposure chamber during a 4-h exposure period. In addition, the exposure system was run in two modes, spark and no spark, which resulted in different chemical profiles and particle size distributions. Complex aerosols were produced that contained both metal particulates and volatile organic compounds (VOCs). Size distribution of the particles was multi-modal. The majority of particles were chain-like agglomerates of ultrafine primary particles. The submicron mode of agglomerated particles accounted for the largest portion of particles in terms of particle number. Metal expulsion during spot welding caused the formation of larger, more spherical particles (spatter). These spatter particles appeared in the micron size mode and accounted for the greatest amount of particles in terms of mass. With this system, it is possible to examine potential mechanisms by which spot welding aerosols can affect health, as well as assess which component of the aerosol may be responsible for adverse health outcomes. JF - Inhalation toxicology AU - Afshari, Aliakbar AU - Zeidler-Erdely, Patti C AU - McKinney, Walter AU - Chen, Bean T AU - Jackson, Mark AU - Schwegler-Berry, Diane AU - Friend, Sherri AU - Cumpston, Amy AU - Cumpston, Jared L AU - Leonard, H Donny AU - Meighan, Terence G AU - Frazer, David G AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health , Morgantown, WV , USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 708 EP - 719 VL - 26 IS - 12 KW - Adhesives KW - 0 KW - Aerosols KW - Air Pollutants, Occupational KW - Metals KW - Particulate Matter KW - Volatile Organic Compounds KW - Steel KW - 12597-69-2 KW - Index Medicus KW - inhalation KW - fumes KW - resistance spot welding KW - Aerosol generators KW - gases KW - United States KW - Animals KW - Fires KW - Steel -- chemistry KW - Volatile Organic Compounds -- chemistry KW - Particle Size KW - Automation, Laboratory KW - Animals, Laboratory KW - Particulate Matter -- chemistry KW - National Institute for Occupational Safety and Health (U.S.) KW - Volatile Organic Compounds -- analysis KW - Particulate Matter -- toxicity KW - Atmosphere Exposure Chambers KW - Volatile Organic Compounds -- toxicity KW - Microscopy, Electron, Scanning KW - Welding -- methods KW - Adhesives -- chemistry KW - Metals -- chemistry KW - Air Pollutants, Occupational -- toxicity KW - Toxicity Tests -- instrumentation KW - Air Pollutants, Occupational -- chemistry KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566822610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Development+and+characterization+of+a+resistance+spot+welding+aerosol+generator+and+inhalation+exposure+system.&rft.au=Afshari%2C+Aliakbar%3BZeidler-Erdely%2C+Patti+C%3BMcKinney%2C+Walter%3BChen%2C+Bean+T%3BJackson%2C+Mark%3BSchwegler-Berry%2C+Diane%3BFriend%2C+Sherri%3BCumpston%2C+Amy%3BCumpston%2C+Jared+L%3BLeonard%2C+H+Donny%3BMeighan%2C+Terence+G%3BFrazer%2C+David+G%3BAntonini%2C+James+M&rft.aulast=Afshari&rft.aufirst=Aliakbar&rft.date=2014-10-01&rft.volume=26&rft.issue=12&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2014.941118 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-05 N1 - Date created - 2014-09-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2014.941118 ER - TY - JOUR T1 - Neurotoxicity following acute inhalation of aerosols generated during resistance spot weld-bonding of carbon steel. AN - 1566822437; 25265048 AB - Welding generates complex metal aerosols, inhalation of which is linked to adverse health effects among welders. An important health concern of welding fume (WF) exposure is neurological dysfunction akin to Parkinson's disease (PD). Some applications in manufacturing industry employ a variant welding technology known as "weld-bonding" that utilizes resistance spot welding, in combination with adhesives, for metal-to-metal welding. The presence of adhesives raises additional concerns about worker exposure to potentially toxic components like Methyl Methacrylate, Bisphenol A and volatile organic compounds (VOCs). Here, we investigated the potential neurotoxicological effects of exposure to welding aerosols generated during weld-bonding. Male Sprague-Dawley rats were exposed (25 mg/m³ targeted concentration; 4 h/day × 13 days) by whole-body inhalation to filtered air or aerosols generated by either weld-bonding with sparking (high metal, low VOCs; HM) or without sparking (low metal; high VOCs; LM). Fumes generated under these conditions exhibited complex aerosols that contained both metal oxide particulates and VOCs. LM aerosols contained a greater fraction of VOCs than HM, which comprised largely metal particulates of ultrafine morphology. Short-term exposure to LM aerosols caused distinct changes in the levels of the neurotransmitters, dopamine (DA) and serotonin (5-HT), in various brain areas examined. LM aerosols also specifically decreased the mRNA expression of the olfactory marker protein (Omp) and tyrosine hydroxylase (Th) in the olfactory bulb. Consistent with the decrease in Th, LM also reduced the expression of dopamine transporter (Slc6a3; Dat), as well as, dopamine D2 receptor (Drd2) in the olfactory bulb. In contrast, HM aerosols induced the expression of Th and dopamine D5 receptor (Drd5) mRNAs, elicited neuroinflammation and blood-brain barrier-related changes in the olfactory bulb, but did not alter the expression of Omp. Our findings divulge the differential effects of LM and HM aerosols in the brain and suggest that exposure to weld-bonding aerosols can potentially elicit neurotoxicity following a short-term exposure. However, further investigations are warranted to determine if the aerosols generated by weld-bonding can contribute to persistent long-term neurological deficits and/or neurodegeneration. JF - Inhalation toxicology AU - Sriram, Krishnan AU - Jefferson, Amy M AU - Lin, Gary X AU - Afshari, Aliakbar AU - Zeidler-Erdely, Patti C AU - Meighan, Terence G AU - McKinney, Walter AU - Jackson, Mark AU - Cumpston, Amy AU - Cumpston, Jared L AU - Leonard, Howard D AU - Frazer, David G AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health , Morgantown, WV , USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 720 EP - 732 VL - 26 IS - 12 KW - Adhesives KW - 0 KW - Aerosols KW - Air Pollutants, Occupational KW - Biomarkers KW - Nerve Tissue Proteins KW - Volatile Organic Compounds KW - Steel KW - 12597-69-2 KW - Index Medicus KW - welding KW - Parkinson's disease KW - neurotoxicity KW - volatile organic compounds KW - welding fume KW - occupational exposure KW - manganese KW - Olfactory Bulb -- immunology KW - Animals KW - Fires KW - Steel -- chemistry KW - Olfactory Bulb -- drug effects KW - Blood-Brain Barrier -- metabolism KW - Nerve Tissue Proteins -- genetics KW - Volatile Organic Compounds -- analysis KW - Oxidation-Reduction KW - Blood-Brain Barrier -- drug effects KW - Rats, Sprague-Dawley KW - Adhesives -- chemistry KW - Toxicity Tests, Acute KW - Blood-Brain Barrier -- immunology KW - Biomarkers -- metabolism KW - Nerve Tissue Proteins -- metabolism KW - Volatile Organic Compounds -- toxicity KW - Gene Expression Regulation -- drug effects KW - Olfactory Bulb -- metabolism KW - Male KW - Welding -- methods KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Brain Chemistry -- drug effects KW - Brain -- drug effects KW - Brain -- metabolism KW - Neurotoxicity Syndromes -- metabolism KW - Brain -- immunology KW - Air Pollutants, Occupational -- toxicity KW - Neurons -- immunology KW - Air Pollutants, Occupational -- chemistry KW - Neurotoxicity Syndromes -- immunology KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566822437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Neurotoxicity+following+acute+inhalation+of+aerosols+generated+during+resistance+spot+weld-bonding+of+carbon+steel.&rft.au=Sriram%2C+Krishnan%3BJefferson%2C+Amy+M%3BLin%2C+Gary+X%3BAfshari%2C+Aliakbar%3BZeidler-Erdely%2C+Patti+C%3BMeighan%2C+Terence+G%3BMcKinney%2C+Walter%3BJackson%2C+Mark%3BCumpston%2C+Amy%3BCumpston%2C+Jared+L%3BLeonard%2C+Howard+D%3BFrazer%2C+David+G%3BAntonini%2C+James+M&rft.aulast=Sriram&rft.aufirst=Krishnan&rft.date=2014-10-01&rft.volume=26&rft.issue=12&rft.spage=720&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2014.954654 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-05 N1 - Date created - 2014-09-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9858-63 [8790421] Brain Res Dev Brain Res. 1996 Mar 29;92(1):24-30 [8861719] Int J Dev Neurosci. 1996 Nov;14(7-8):971-82 [9010739] Inhal Toxicol. 2004 Jun;16(6-7):437-45 [15204759] Physiol Rev. 2004 Jul;84(3):869-901 [15269339] Histochem Cell Biol. 2004 Aug;122(2):131-7 [15258771] Br J Ind Med. 1971 Jan;28(1):78-82 [5101169] Brain Res. 1977 May 13;126(3):455-74 [16685] Brain Res. 1985 Sep 16;343(1):166-71 [2864104] Neurotoxicology. 1987 Fall;8(3):451-62 [3309736] Lancet. 1997 Apr 26;349(9060):1239-43 [9130958] Environ Res. 1997;73(1-2):92-100 [9311535] Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):207-14 [9716942] Neuroradiology. 1998 Aug;40(8):519-21 [9763341] Brain Res Mol Brain Res. 1999 May 7;68(1-2):22-8 [10320780] Am J Respir Crit Care Med. 1999 Jun;159(6):1943-8 [10351943] Neurotoxicology. 1999 Apr-Jun;20(2-3):287-97 [10385891] Br J Ind Med. 1955 Jan;12(1):21-35 [14351643] Neurology. 2005 Jan 25;64(2):230-5 [15668418] Neurotoxicology. 2006 May;27(3):315-26 [16343629] Am J Ind Med. 2006 Jun;49(6):407-16 [16691606] Behav Brain Res. 2006 Sep 15;172(1):97-105 [16765459] Environ Health Perspect. 2006 Aug;114(8):1172-8 [16882521] Occup Environ Med. 2007 Mar;64(3):167-77 [17018581] Neurotoxicology. 2007 Mar;28(2):298-311 [17169432] Neurotoxicology. 2007 May;28(3):478-89 [17175027] Environ Res. 2007 Jul;104(3):420-32 [17445792] Am J Ind Med. 2007 Nov;50(11):788-800 [17918215] Neurochem Res. 2009 May;34(5):953-63 [18850267] Occup Med (Lond). 2009 Jun;59(4):267-9 [19286991] Arch Toxicol. 2010 Jul;84(7):521-40 [20224926] FASEB J. 2010 Dec;24(12):4989-5002 [20798247] Toxicol Sci. 2012 Mar;126(1):183-92 [22174044] J Immunol. 2012 Sep 15;189(6):3130-9 [22896632] Neurochem Int. 2013 Mar;62(4):389-98 [23357475] Inhal Toxicol. 2014 Oct;26(12):708-19 [25140455] Cell Mol Neurobiol. 2000 Feb;20(1):57-76 [10690502] J Toxicol Clin Toxicol. 2000;38(1):37-41 [10696922] Exp Neurol. 2000 May;163(1):1-8 [10785438] Neurology. 2001 Jan 9;56(1):8-13 [11148228] Antioxid Redox Signal. 2001 Apr;3(2):273-8 [11396481] Ann Neurol. 2001 Jul;50(1):34-41 [11456307] Trends Neurosci. 2001 Dec;24(12):719-25 [11718877] Am J Ind Med. 2002 Feb;41(2):77-88 [11813212] FASEB J. 2002 Sep;16(11):1474-6 [12205053] J Toxicol Environ Health A. 2002 Oct 25;65(20):1531-43 [12396867] J Cell Biol. 2003 May 12;161(3):653-60 [12743111] Occup Med (Lond). 2003 Oct;53(7):479-82 [14581647] J Occup Environ Med. 2004 Apr;46(4):323-30 [15076649] Parkinsonism Relat Disord. 2004 May;10 Suppl 1:S3-7 [15109580] BMC Neurosci. 2004 Apr 2;5:12 [15061865] Nihon Hoigaku Zasshi. 1990 Feb;44(1):25-33 [2366393] Scand J Work Environ Health. 1991 Aug;17(4):255-62 [1925437] Br J Ind Med. 1991 Nov;48(11):750-61 [1954153] Toxicol Sci. 2005 Mar;84(1):139-48 [15601679] Neurology. 2005 Jun 28;64(12):2033-9 [15888601] J Occup Environ Med. 2005 Jul;47(7):728-39 [16010199] J Neurochem. 2006 Feb;96(3):706-18 [16405514] Occup Environ Med. 2006 Mar;63(3):221-6, 179 [16497867] FASEB J. 2006 Apr;20(6):670-82 [16581975] Toxicology. 1993 Mar 19;77(3):223-32 [8096348] Environ Res. 1993 Apr;61(1):107-16 [8472664] Environ Res. 1993 Aug;62(2):303-13 [8344237] Neurosci Lett. 1994 Jan 3;165(1-2):208-10 [8015728] Genomics. 1994 Apr;20(3):452-62 [8034318] J Neurosci. 1995 Aug;15(8):5574-81 [7643202] AJNR Am J Neuroradiol. 1995 Sep;16(8):1643-9 [7502969] Proc Natl Acad Sci U S A. 1996 Feb 6;93(3):1325-9 [8577763] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2014.954654 ER - TY - JOUR T1 - Effects of acute inhalation of aerosols generated during resistance spot welding with mild-steel on pulmonary, vascular and immune responses in rats. AN - 1566822377; 25140454 AB - Spot welding is used in the automotive and aircraft industries, where high-speed, repetitive welding is needed to join thin sections of metal. Epoxy adhesives are applied as sealers to the metal seams. Pulmonary function abnormalities and airway irritation have been reported in spot welders, but no animal toxicology studies exist. Therefore, the goal of this study was to investigate vascular, immune and lung toxicity measures after exposure to these metal fumes in an animal model. Male Sprague-Dawley rats were exposed by inhalation to 25 mg/m³ to either mild-steel spot welding aerosols with sparking (high metal, HM) or without sparking (low metal, LM) for 4 h/d for 3, 8 and 13 d. Shams were exposed to filtered air. Bronchoalveolar lavage (BAL), lung gene expression and ex vivo BAL cell challenge were performed to assess lung toxicity. Lung resistance (R(L)) was evaluated before and after challenge with inhaled methacholine (MCh). Functional assessment of the vascular endothelium in isolated rat tail arteries and leukocyte differentiation in the spleen and lymph nodes via flow cytometry was also done. Immediately after exposure, baseline R(L) was significantly elevated in the LM spot welding aerosols, but returned to control level by 24 h postexposure. Airway reactivity to MCh was unaffected. Lung inflammation and cytotoxicity were mild and transient. Lung epithelial permeability was significantly increased after 3 and 8 d, but not after 13 d of exposure to the HM aerosol. HM aerosols also caused vascular endothelial dysfunction and increased CD4+, CD8+ and B cells in the spleen. Only LM aerosols caused increased IL-6 and MCP-1 levels compared with sham after ex vivo LPS stimulation in BAL macrophages. Acute inhalation of mild-steel spot welding fumes at occupationally relevant concentrations may act as an irritant as evidenced by the increased R(L) and result in endothelial dysfunction, but otherwise had minor effects on the lung. JF - Inhalation toxicology AU - Zeidler-Erdely, Patti C AU - Meighan, Terence G AU - Erdely, Aaron AU - Fedan, Jeffrey S AU - Thompson, Janet A AU - Bilgesu, Suzan AU - Waugh, Stacey AU - Anderson, Stacey AU - Marshall, Nikki B AU - Afshari, Aliakbar AU - McKinney, Walter AU - Frazer, David G AU - Antonini, James M AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health , Morgantown, WV , USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 697 EP - 707 VL - 26 IS - 12 KW - Adhesives KW - 0 KW - Aerosols KW - Air Pollutants, Occupational KW - Steel KW - 12597-69-2 KW - Index Medicus KW - particulate matter KW - inhalation studies KW - welding KW - volatile organic compounds KW - Cardiovascular KW - Specific Pathogen-Free Organisms KW - Immunity, Mucosal -- drug effects KW - Animals KW - Fires KW - Steel -- chemistry KW - Leukocytes -- immunology KW - Spleen -- pathology KW - Macrophages, Alveolar -- drug effects KW - Leukocytes -- drug effects KW - Rats, Sprague-Dawley KW - Adhesives -- chemistry KW - Cells, Cultured KW - Leukocytes -- pathology KW - Toxicity Tests, Acute KW - Spleen -- immunology KW - Spleen -- drug effects KW - Macrophages, Alveolar -- pathology KW - Macrophages, Alveolar -- immunology KW - Male KW - Hematopoiesis, Extramedullary -- drug effects KW - Welding -- methods KW - Vasculitis -- chemically induced KW - Respiratory Mucosa -- immunology KW - Respiratory Mucosa -- drug effects KW - Vasculitis -- pathology KW - Vasculitis -- immunology KW - Air Pollutants, Occupational -- toxicity KW - Endothelium, Vascular -- physiopathology KW - Lung -- pathology KW - Endothelium, Vascular -- immunology KW - Respiratory Mucosa -- pathology KW - Vasculitis -- physiopathology KW - Lung -- blood supply KW - Lung -- immunology KW - Endothelium, Vascular -- drug effects KW - Lung -- drug effects KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566822377?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Effects+of+acute+inhalation+of+aerosols+generated+during+resistance+spot+welding+with+mild-steel+on+pulmonary%2C+vascular+and+immune+responses+in+rats.&rft.au=Zeidler-Erdely%2C+Patti+C%3BMeighan%2C+Terence+G%3BErdely%2C+Aaron%3BFedan%2C+Jeffrey+S%3BThompson%2C+Janet+A%3BBilgesu%2C+Suzan%3BWaugh%2C+Stacey%3BAnderson%2C+Stacey%3BMarshall%2C+Nikki+B%3BAfshari%2C+Aliakbar%3BMcKinney%2C+Walter%3BFrazer%2C+David+G%3BAntonini%2C+James+M&rft.aulast=Zeidler-Erdely&rft.aufirst=Patti&rft.date=2014-10-01&rft.volume=26&rft.issue=12&rft.spage=697&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2014.944287 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-05 N1 - Date created - 2014-09-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Occup Med (Lond). 2010 Dec;60(8):624-30 [20819803] Nano Lett. 2009 Jan;9(1):36-43 [19049393] Arch Toxicol. 2011 May;85(5):487-98 [20924559] Toxicol Lett. 2011 Jul 4;204(1):12-6 [21513782] Toxicology. 2011 Sep 5;287(1-3):153-9 [21708214] Inhal Toxicol. 2012 Apr;24(5):270-87 [22486345] J Immunotoxicol. 2012 Apr-Jun;9(2):184-92 [22369286] PLoS One. 2012;7(7):e39817 [22802943] J Toxicol Sci. 2012;37(4):739-48 [22863854] Environ Res. 2012 Oct;118:118-23 [22776327] J Immunotoxicol. 2012 Oct-Dec;9(4):411-25 [22734811] Curr Allergy Asthma Rep. 2013 Feb;13(1):1-9 [23076420] Nat Rev Cardiol. 2013 Sep;10(9):519-30 [23856679] Res Rep Health Eff Inst. 2013 Oct;(178):5-8 [24377210] Inhal Toxicol. 2014 Oct;26(12):708-19 [25140455] Inhal Toxicol. 2014 Oct;26(12):720-32 [25265048] Occup Environ Med. 2000 Feb;57(2):86-93 [10711275] Epidemiology. 2000 Mar;11(2):136-40 [11021609] Arch Environ Health. 2001 May-Jun;56(3):234-41 [11480499] Int J Occup Environ Health. 2002 Oct-Dec;8(4):309-11 [12412847] Environ Health Perspect. 2003 Apr;111(4):647-56 [12676630] J Expo Anal Environ Epidemiol. 2003 Sep;13(5):348-63 [12973363] Occup Environ Med. 2005 Mar;62(3):157-63 [15723880] Inhal Toxicol. 2009 Feb;21(3):182-92 [18925477] Cytokine. 2009 May;46(2):290-5 [19303319] Occup Med (Lond). 2009 Jun;59(4):267-9 [19286991] Occup Environ Med. 2010 Jan;67(1):11-6 [19736177] Sci Total Environ. 2010 Mar 15;408(8):1818-23 [20163830] J Occup Environ Hyg. 2010 Jun;7(6):367-74 [20397091] J Appl Physiol (1985). 2010 May;108(5):1357-64 [20224000] Circulation. 2010 Jun 1;121(21):2331-78 [20458016] Occup Environ Med. 2010 Nov;67(11):772-7 [20581417] J Occup Environ Med. 2005 Jul;47(7):728-39 [16010199] Toxicol Sci. 2005 Nov;88(1):95-102 [16093524] Am J Ind Med. 2006 Jun;49(6):407-16 [16691606] Toxicol Appl Pharmacol. 2007 Sep 15;223(3):234-45 [17706736] J Thorac Cardiovasc Surg. 2008 Oct;136(4):1044-53 [18954648] Inhal Toxicol. 2011 Feb;23(2):112-20 [21309664] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2014.944287 ER - TY - JOUR T1 - Lung biodurability and free radical production of cellulose nanomaterials. AN - 1566820120; 25265049 AB - Abstract The potential applications of cellulose nanomaterials in advanced composites and biomedicine makes it imperative to understand their pulmonary exposure to human health. Here, we report the results on the biodurability of three cellulose nanocrystal (CNC), two cellulose nanofibril (CNF) and a benchmark cellulose microcrystal (CMC) when exposed to artificial lung airway lining fluid (SUF, pH 7.3) for up to 7 days and alveolar macrophage phagolysosomal fluid (PSF, pH 4.5) for up to 9 months. X-ray diffraction analysis was used to monitor biodurability and thermogravimetry, surface area, hydrodynamic diameter, zeta potential and free radical generation capacity of the samples were determined (in vitro cell-free and RAW 264.7 cell line models). The CMC showed no measurable changes in crystallinity (x(CR)) or crystallite size D in either SUF or PSF. For one CNC, a slight decrease in x(CR) and D in SUF was observed. In acidic PSF, a slight increase in x(CR) with exposure time was observed, possibly due to dissolution of the amorphous component. In a cell-free reaction with H₂O₂, radicals were observed; the CNCs and a CNF generated significantly more ·OH radicals than the CMC (p < 0.05). The ·OH radical production correlates with particle decomposition temperature and is explained by the higher surface area to volume ratio of the CNCs. Based on their biodurability, mechanical clearance would be the primary mechanism for lung clearance of cellulose materials. The production of ·OH radicals indicates the need for additional studies to characterize the potential inhalation hazards of cellulose. JF - Inhalation toxicology AU - Stefaniak, Aleksandr B AU - Seehra, Mohindar S AU - Fix, Natalie R AU - Leonard, Stephen S AD - Division of Respiratory Diseases Studies, National Institute for Occupational Safety and Health , Morgantown, WV , USA . Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 733 EP - 749 VL - 26 IS - 12 KW - Free Radicals KW - 0 KW - Cellulose KW - 9004-34-6 KW - Index Medicus KW - pulmonary inflammation KW - Biodurability KW - cellulose nanocrystals and nanofibrils KW - X-ray diffraction KW - microcrystalline cellulose KW - free radicals KW - Respiratory Burst -- drug effects KW - Animals KW - Nanofibers -- chemistry KW - Particle Size KW - Mucociliary Clearance -- drug effects KW - Mice KW - Macrophages, Alveolar -- drug effects KW - Nanoparticles -- toxicity KW - Nanofibers -- ultrastructure KW - Macrophages, Alveolar -- metabolism KW - Nanoparticles -- metabolism KW - Bronchoalveolar Lavage Fluid -- chemistry KW - Nanoparticles -- ultrastructure KW - Phagocytosis -- drug effects KW - Cell Line, Transformed KW - Pulmonary Elimination -- drug effects KW - Macrophages, Alveolar -- immunology KW - Macrophages, Alveolar -- secretion KW - Nanofibers -- toxicity KW - Surface Properties KW - Nanoparticles -- chemistry KW - Lung -- secretion KW - Nanostructures -- ultrastructure KW - Respiratory Mucosa -- immunology KW - Respiratory Mucosa -- drug effects KW - Cellulose -- toxicity KW - Cellulose -- chemistry KW - Respiratory Mucosa -- secretion KW - Lung -- metabolism KW - Free Radicals -- metabolism KW - Models, Biological KW - Nanostructures -- toxicity KW - Lung -- immunology KW - Respiratory Mucosa -- metabolism KW - Cellulose -- metabolism KW - Nanostructures -- chemistry KW - Lung -- drug effects KW - Cellulose -- ultrastructure KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566820120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Inhalation+toxicology&rft.atitle=Lung+biodurability+and+free+radical+production+of+cellulose+nanomaterials.&rft.au=Stefaniak%2C+Aleksandr+B%3BSeehra%2C+Mohindar+S%3BFix%2C+Natalie+R%3BLeonard%2C+Stephen+S&rft.aulast=Stefaniak&rft.aufirst=Aleksandr&rft.date=2014-10-01&rft.volume=26&rft.issue=12&rft.spage=733&rft.isbn=&rft.btitle=&rft.title=Inhalation+toxicology&rft.issn=1091-7691&rft_id=info:doi/10.3109%2F08958378.2014.948650 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-05 N1 - Date created - 2014-09-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Appl Toxicol. 2000 Jan-Feb;20(1):49-60 [10641016] ACS Appl Mater Interfaces. 2009 Sep;1(9):1996-2004 [20355825] Health Phys. 1973 May;24(5):497-507 [4707664] Exp Lung Res. 1985;9(1-2):1-16 [4065055] Free Radic Biol Med. 1987;3(4):259-303 [2826304] J Appl Toxicol. 1995 Jan-Feb;15(1):45-8 [7745224] Eur J Pharm Biopharm. 1998 Nov;46(3):255-63 [9885296] Am J Ind Med. 1999 Sep;Suppl 1:158-60 [10519821] Toxicol In Vitro. 2005 Feb;19(1):123-34 [15582363] Free Radic Biol Med. 2006 Apr 1;40(7):1227-33 [16545691] Environ Health Perspect. 2007 Feb;115(2):187-94 [17384763] Methods Mol Biol. 2007;412:349-63 [18453123] Chem Rev. 2010 Jun 9;110(6):3479-500 [20201500] Part Fibre Toxicol. 2010;7:32 [21047424] Nanomedicine (Lond). 2011 Jan;6(1):143-56 [21182425] Biomacromolecules. 2009 Jul 13;10(7):1992-6 [19445519] Chem Soc Rev. 2011 Jul;40(7):3941-94 [21566801] Biomacromolecules. 2011 Oct 10;12(10):3638-44 [21888417] Nanotoxicology. 2011 Dec;5(4):711-29 [21073401] Nanoscale. 2012 Feb 21;4(4):1373-9 [22252333] Biomacromolecules. 2012 May 14;13(5):1486-94 [22482888] ACS Appl Mater Interfaces. 2012 Aug;4(8):4078-86 [22839594] Carbohydr Polym. 2013 Jan 16;91(2):711-7 [23121968] Nanotechnology. 2013 Feb 22;24(7):075103 [23358497] Macromol Biosci. 2013 Mar;13(3):289-98 [23225770] Acc Chem Res. 2013 Mar 19;46(3):723-32 [23003923] J Environ Pathol Toxicol Oncol. 2000;19(1-2):49-60 [10905508] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/08958378.2014.948650 ER - TY - JOUR T1 - Impact of study design on the evaluation of inhaled and intranasal corticosteroids' effect on hypothalamic-pituitary-adrenal axis function. AN - 1566110638; 25103275 AB - In part I of this review, an overview of the designs of hypothalamic-pituitary-adrenal (HPA) axis studies in the setting of inhaled corticosteroids (ICS) or intranasal corticosteroids (INS) use was discussed. Part II provides detailed discussion on the HPA axis evaluation results for each common ICS and INS, and how these results are possibly affected by the factors of study design. Significant adrenal suppression at conventional ICS/INS doses appears to be rare in clinical settings. The magnitude of cortisol suppression varies widely among different study designs. Factors potentially impacting this variability include: the choice of dose, dosing duration, assay sensitivity, statistical methodology, study population, and compliance. All of these factors have the potential to affect the extent of HPA axis effects detected and should be considered when designing or interpreting the results of a HPA axis study. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association. JF - Journal of pharmaceutical sciences AU - Fan, Ying AU - Ma, Lian AU - Pippins, Jennifer AU - Limb, Susan AU - Xu, Yun AU - Sahajwalla, Chandrahas G AD - Division of Clinical Pharmacology II, Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, Maryland. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 2963 EP - 2979 VL - 103 IS - 10 KW - Adrenal Cortex Hormones KW - 0 KW - Index Medicus KW - inhaled corticosteroids KW - pediatrics KW - toxicity KW - study design KW - pulmonary KW - hypothalamic-pituitary-adrenal (HPA) axis KW - pharmacodynamics KW - intranasal corticosteroids KW - regulatory science KW - Humans KW - Administration, Intranasal KW - Adult KW - Adolescent KW - Administration, Inhalation KW - Hypothalamo-Hypophyseal System -- drug effects KW - Adrenal Cortex Hormones -- pharmacology KW - Adrenal Cortex Hormones -- administration & dosage KW - Pituitary-Adrenal System -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566110638?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pharmaceutical+sciences&rft.atitle=Impact+of+study+design+on+the+evaluation+of+inhaled+and+intranasal+corticosteroids%27+effect+on+hypothalamic-pituitary-adrenal+axis+function.&rft.au=Fan%2C+Ying%3BMa%2C+Lian%3BPippins%2C+Jennifer%3BLimb%2C+Susan%3BXu%2C+Yun%3BSahajwalla%2C+Chandrahas+G&rft.aulast=Fan&rft.aufirst=Ying&rft.date=2014-10-01&rft.volume=103&rft.issue=10&rft.spage=2963&rft.isbn=&rft.btitle=&rft.title=Journal+of+pharmaceutical+sciences&rft.issn=1520-6017&rft_id=info:doi/10.1002%2Fjps.24089 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-01 N1 - Date created - 2014-09-25 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jps.24089 ER - TY - JOUR T1 - Methamphetamine and amphetamine isomer concentrations in human urine following controlled Vicks VapoInhaler administration. AN - 1561978911; 25217541 AB - Legitimate use of legal intranasal decongestants containing l-methamphetamine may complicate interpretation of urine drug tests positive for amphetamines. Our study hypotheses were that commonly used immunoassays would produce no false-positive results and a recently developed enantiomer-specific gas chromatography-mass spectrometry (GC-MS) procedure would find no d-amphetamine or d-methamphetamine in urine following controlled Vicks VapoInhaler administration at manufacturer's recommended doses. To evaluate these hypotheses, 22 healthy adults were each administered one dose (two inhalations in each nostril) of a Vicks VapoInhaler every 2 h for 10 h on Day 1 (six doses), followed by a single dose on Day 2. Every urine specimen was collected as an individual void for 32 h after the first dose and assayed for d- and l-amphetamines specific isomers with a GC-MS method with >99% purity of R-(-)-α-methoxy-α-(trifluoromethyl)phenylacetyl derivatives and 10 µg/L lower limits of quantification. No d-methamphetamine or d-amphetamine was detected in any urine specimen by GC-MS. The median l-methamphetamine maximum concentration was 62.8 µg/L (range: 11.0-1,440). Only two subjects had detectable l-amphetamine, with maximum concentrations coinciding with l-methamphetamine peak levels, and always ≤ 4% of the parent's maximum. Three commercial immunoassays for amphetamines EMIT(®) II Plus, KIMS(®) II and DRI(®) had sensitivities, specificities and efficiencies of 100, 97.8, 97.8; 100, 99.6, 99.6 and 100, 100, 100%, respectively. The immunoassays had high efficiencies, but our first hypothesis was not affirmed. The EMIT(®) II Plus assay produced 2.2% false-positive results, requiring an enantiomer-specific confirmation. Published by Oxford University Press 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US. JF - Journal of analytical toxicology AU - Smith, Michael L AU - Nichols, Daniel C AU - Underwood, Paula AU - Fuller, Zachary AU - Moser, Matthew A AU - Flegel, Ron AU - Gorelick, David A AU - Newmeyer, Matthew N AU - Concheiro, Marta AU - Huestis, Marilyn A AD - U.S. Army Forensic Toxicology Drug Testing Laboratory, Fort Meade, MD, USA. ; Division of Workplace Programs, Department of Health and Human Services, Substance Abuse Mental Health Services Administration, Rockville, MD, USA. ; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Suite 200 Room 05A-721, Baltimore, MD 21224, USA Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. ; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Suite 200 Room 05A-721, Baltimore, MD 21224, USA Program in Toxicology, University of Maryland Baltimore, Baltimore, MD, USA. ; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Suite 200 Room 05A-721, Baltimore, MD 21224, USA. ; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 251 Bayview Blvd., Suite 200 Room 05A-721, Baltimore, MD 21224, USA mhuestis@intra.nida.nih.gov. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 524 EP - 527 VL - 38 IS - 8 KW - Methamphetamine KW - 44RAL3456C KW - Creatinine KW - AYI8EX34EU KW - Amphetamine KW - CK833KGX7E KW - Index Medicus KW - Sensitivity and Specificity KW - Young Adult KW - Stereoisomerism KW - Creatinine -- urine KW - Dose-Response Relationship, Drug KW - Humans KW - Specimen Handling KW - Aged KW - Substance Abuse Detection -- methods KW - False Positive Reactions KW - Immunoassay -- methods KW - Adult KW - Gas Chromatography-Mass Spectrometry KW - Middle Aged KW - Healthy Volunteers KW - Administration, Inhalation KW - Adolescent KW - Male KW - Female KW - Methamphetamine -- urine KW - Amphetamine -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561978911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+analytical+toxicology&rft.atitle=Methamphetamine+and+amphetamine+isomer+concentrations+in+human+urine+following+controlled+Vicks+VapoInhaler+administration.&rft.au=Smith%2C+Michael+L%3BNichols%2C+Daniel+C%3BUnderwood%2C+Paula%3BFuller%2C+Zachary%3BMoser%2C+Matthew+A%3BFlegel%2C+Ron%3BGorelick%2C+David+A%3BNewmeyer%2C+Matthew+N%3BConcheiro%2C+Marta%3BHuestis%2C+Marilyn+A&rft.aulast=Smith&rft.aufirst=Michael&rft.date=2014-10-01&rft.volume=38&rft.issue=8&rft.spage=524&rft.isbn=&rft.btitle=&rft.title=Journal+of+analytical+toxicology&rft.issn=1945-2403&rft_id=info:doi/10.1093%2Fjat%2Fbku077 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-05 N1 - Date created - 2014-09-13 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Clin Chem. 1977 Aug;23(8):1504 [872410] BMC Clin Pharmacol. 2008;8:4 [18644153] J Anal Toxicol. 2004 Sep;28(6):449-55 [15516295] J Anal Toxicol. 1988 Sep-Oct;12(5):255-9 [3226121] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/jat/bku077 ER - TY - JOUR T1 - Signal detection for Thai traditional medicine: examination of national pharmacovigilance data using reporting odds ratio and reported population attributable risk. AN - 1561974862; 24945744 AB - Herbal containing medicine consumption has increased while the awareness of adverse drug reaction (ADR) was less than conventional medicine. Early detection of unexpected numbers of ADRs from herbal medicines' reports which are abnormal from the whole database needs quantification. Disproportionality analysis has been performed for signal detection by using reporting odds ratio (ROR) as measurement. The impact of having medicine as exposures in each ADR should be measured by using reported population attributable risks (RPAR). This study aimed to quantify the contribution of Thai traditional medicine (TTM) to ADR reports and to assess the association between TTMs and serious adverse drug reactions. Data were retrieved from the adverse drug reaction surveillance database, Thai-Food and Drug Administration from 2002 to 2013. Crude and adjusted RORs for each drug-ADR pair and RPARs were computed. TTM contributed only 0.001% of all serious ADRs reported. Out of 4208 TTM-ADR pairs were examined, three had the statistically significant RORs, namely Andrographis paniculata and anaphylactic shock (ROR 2.32, 95% CI 1.03, 5.21); green traditional medicine and Stevens-Johnson syndrome (ROR 13.04, 95% CI 5.4-31.51) and Derris scandens Benth and angioedema (ROR 2.71, 95% CI 1.05-6.95). Their RPARs ranged from 0.05% to 0.16%. We conclude that TTMs need more intensive surveillance. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Wechwithan, Sareeya AU - Suwankesawong, Wimon AU - Sornsrivichai, Vorasith AU - McNeil, Edward B AU - Jiraphongsa, Chuleeporn AU - Chongsuvivatwong, Virasakdi AD - Health Product Vigilance Center, Food and Drug Administration, Ministry of Public Health, 11000, Thailand; Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand. ; Health Product Vigilance Center, Food and Drug Administration, Ministry of Public Health, 11000, Thailand. ; Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand. ; Field Epidemiology Training Program (FETP), Bureau of Epidemiology, Department of Disease Control, Ministry of Public Health, 11000, Thailand. ; Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand. Electronic address: cvirasak@medicine.psu.ac.th. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 407 EP - 412 VL - 70 IS - 1 KW - Plant Preparations KW - 0 KW - Index Medicus KW - Reporting odds ratio KW - ADR KW - Serious ADR KW - Herbal medicine KW - Thai traditional medicine KW - Odds Ratio KW - Humans KW - Databases, Factual KW - Adverse Drug Reaction Reporting Systems -- statistics & numerical data KW - Thailand -- epidemiology KW - Medicine, East Asian Traditional -- adverse effects KW - Pharmacovigilance KW - Plant Preparations -- adverse effects KW - Drug-Related Side Effects and Adverse Reactions -- etiology KW - Drug-Related Side Effects and Adverse Reactions -- epidemiology KW - Plants, Medicinal -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561974862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Signal+detection+for+Thai+traditional+medicine%3A+examination+of+national+pharmacovigilance+data+using+reporting+odds+ratio+and+reported+population+attributable+risk.&rft.au=Wechwithan%2C+Sareeya%3BSuwankesawong%2C+Wimon%3BSornsrivichai%2C+Vorasith%3BMcNeil%2C+Edward+B%3BJiraphongsa%2C+Chuleeporn%3BChongsuvivatwong%2C+Virasakdi&rft.aulast=Wechwithan&rft.aufirst=Sareeya&rft.date=2014-10-01&rft.volume=70&rft.issue=1&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-15 N1 - Date created - 2014-09-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.06.007 ER - TY - JOUR T1 - Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials. AN - 1561974351; 25078890 AB - An international expert group which includes 30 organisations (pharmaceutical companies, contract research organisations, academic institutions and regulatory bodies) has shared data on the use of recovery animals in the assessment of pharmaceutical safety for early development. These data have been used as an evidence-base to make recommendations on the inclusion of recovery animals in toxicology studies to achieve scientific objectives, while reducing animal use. Recovery animals are used in pharmaceutical development to provide information on the potential for a toxic effect to translate into long-term human risk. They are included on toxicology studies to assess whether effects observed during dosing persist or reverse once treatment ends. The group devised a questionnaire to collect information on the use of recovery animals in general regulatory toxicology studies to support first-in-human studies. Questions focused on study design, the rationale behind inclusion or exclusion and the impact this had on internal and regulatory decisions. Data on 137 compounds (including 53 biologicals and 78 small molecules) from 259 studies showed wide variation in where, when and why recovery animals were included. An analysis of individual study and programme design shows that there are opportunities to reduce the use of recovery animals without impacting drug development. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Sewell, Fiona AU - Chapman, Kathryn AU - Baldrick, Paul AU - Brewster, David AU - Broadmeadow, Alan AU - Brown, Paul AU - Burns-Naas, Leigh Ann AU - Clarke, Janet AU - Constan, Alex AU - Couch, Jessica AU - Czupalla, Oliver AU - Danks, Andy AU - DeGeorge, Joseph AU - de Haan, Lolke AU - Hettinger, Klaudia AU - Hill, Marilyn AU - Festag, Matthias AU - Jacobs, Abby AU - Jacobson-Kram, David AU - Kopytek, Stephan AU - Lorenz, Helga AU - Moesgaard, Sophia Gry AU - Moore, Emma AU - Pasanen, Markku AU - Perry, Rick AU - Ragan, Ian AU - Robinson, Sally AU - Schmitt, Petra M AU - Short, Brian AU - Lima, Beatriz Silva AU - Smith, Diane AU - Sparrow, Sue AU - van Bekkum, Yvette AU - Jones, David AD - UK National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Road, London NW1 2BE, UK. Electronic address: fiona.sewell@nc3rs.org.uk. ; UK National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs), Gibbs Building, 215 Euston Road, London NW1 2BE, UK. ; Covance Laboratories Ltd, Otley Road, Harrogate HG3 1PY, UK. ; Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, MA 02139, USA. ; Huntingdon Life Sciences Ltd, Occold, Eye, Suffolk IP23 7PX, UK. ; Food and Drug Administration (FDA), 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA. ; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA. ; Biogen Idec, Cambridge, MA 02142, USA. ; Infinity Pharmaceuticals, 780 Memorial Drive, Cambridge, MA 02139, USA. ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. ; Bayer Pharma AG, Müllerstrasse 170, 13353 Berlin, Germany. ; Charles River Laboratories, Preclinical Services, Tranent, Edinburgh EH33 2NE, UK. ; Merck, 770 Sumneytown Pike, Mailstop WP45-201, West Point, PA 19486, USA. ; MedImmune, Granta Park, Cambridge CB21 6GH, UK. ; Austrian Agency for Health and Food Safety, Traisengasse 5, 1200 Vienna, Austria. ; Novartis Institutes for BioMedical Research (NIBR), Basel, Switzerland. ; Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, CH - 4070 Basel, Switzerland. ; Celgene, 86 Morris Avenue, Summit, NJ 07901, USA. ; AbbVie Deutschland GmbH & Co. KG, Knollstrasse, 67061 Ludwigshafen, Germany. ; Novo Nordisk A/S, Novo Nordisk Park, Maaloev, Denmark. ; Huntingdon Life Sciences Ltd, Alconbury, Huntingdon, Cambridgeshire PE28 4HS, UK. ; University of Eastern Finland, Faculty of Health Sciences, School of Pharmacy, Kuopio, Finland. ; Pfizer Drug Safety Research and Development, 455 Eastern Point Rd., Groton, CT 06340, USA. ; Board member, NC3Rs, Gibbs Building, 215 Euston Road, London NW1 2BE, UK. ; AstraZeneca, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK. ; Paul-Ehrlich-Institute, Federal Agency for Vaccines and Biomedicines, Langen, Germany. ; Allergan, Drug Safety Evaluation, 2525 Dupont Dr, RD-2A, Irvine, CA 92612-1599, USA. ; iMED, UL, University of Lisbon, Portugal. ; Millenium: The Takeda Oncology Company, 40 Landsdowne St., Cambridge, MA, USA. ; GlaxoSmithKline, Park Road, Ware, Hertfordshire SG12 0DP, UK. ; Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium. ; Medicines Healthcare Products Regulatory Agency (MHRA), UK. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 413 EP - 429 VL - 70 IS - 1 KW - Index Medicus KW - Reversibility KW - Reduction KW - Regulatory toxicology KW - Non-clinical KW - Repeat-dose studies KW - Recovery KW - Dog KW - 3Rs KW - Rodent KW - Primate KW - Animals KW - International Cooperation KW - Humans KW - Surveys and Questionnaires KW - Time Factors KW - Research Design KW - Models, Animal KW - Toxicology -- methods KW - Drug Evaluation, Preclinical -- methods KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561974351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Recommendations+from+a+global+cross-company+data+sharing+initiative+on+the+incorporation+of+recovery+phase+animals+in+safety+assessment+studies+to+support+first-in-human+clinical+trials.&rft.au=Sewell%2C+Fiona%3BChapman%2C+Kathryn%3BBaldrick%2C+Paul%3BBrewster%2C+David%3BBroadmeadow%2C+Alan%3BBrown%2C+Paul%3BBurns-Naas%2C+Leigh+Ann%3BClarke%2C+Janet%3BConstan%2C+Alex%3BCouch%2C+Jessica%3BCzupalla%2C+Oliver%3BDanks%2C+Andy%3BDeGeorge%2C+Joseph%3Bde+Haan%2C+Lolke%3BHettinger%2C+Klaudia%3BHill%2C+Marilyn%3BFestag%2C+Matthias%3BJacobs%2C+Abby%3BJacobson-Kram%2C+David%3BKopytek%2C+Stephan%3BLorenz%2C+Helga%3BMoesgaard%2C+Sophia+Gry%3BMoore%2C+Emma%3BPasanen%2C+Markku%3BPerry%2C+Rick%3BRagan%2C+Ian%3BRobinson%2C+Sally%3BSchmitt%2C+Petra+M%3BShort%2C+Brian%3BLima%2C+Beatriz+Silva%3BSmith%2C+Diane%3BSparrow%2C+Sue%3Bvan+Bekkum%2C+Yvette%3BJones%2C+David&rft.aulast=Sewell&rft.aufirst=Fiona&rft.date=2014-10-01&rft.volume=70&rft.issue=1&rft.spage=413&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.07.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-15 N1 - Date created - 2014-09-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.07.018 ER - TY - JOUR T1 - More methemoglobin is produced by benzocaine treatment than lidocaine treatment in human in vitro systems. AN - 1561973652; 25010377 AB - The clinical use of local anesthetic products to anesthetize mucous membranes has been associated with methemoglobinemia (MetHba), a serious condition in which the blood has reduced capacity to carry oxygen. An evaluation of spontaneous adverse event reporting of MetHba submitted to FDA through 2013 identified 375 reports associated with benzocaine and 16 reports associated with lidocaine. The current study was performed to determine the relative ability of benzocaine and lidocaine to produce methemoglobin (MetHb) in vitro. Incubation of 500μM benzocaine with whole human blood and pooled human liver S9 over 5h resulted in MetHb levels equaling 39.8±1.2% of the total hemoglobin. No MetHb formation was detected for 500μM lidocaine under the same conditions. Because liver S9 does not readily form lidocaine hydrolytic metabolites based on xylidine, a primary metabolic pathway, 500μM xylidine was directly incubated with whole blood and S9. Under these conditions MetHb levels of 4.4±0.4% were reached by 5h. Studies with recombinant cytochrome P450 revealed benzocaine to be extensively metabolized by CYP 1A2, with 2B6, 2C19, 2D6, and 2E1 also having activity. We conclude that benzocaine produces much more MetHb in in vitro systems than lidocaine or xylidine and that benzocaine should be more likely to cause MetHba in vivo as well. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Hartman, Neil R AU - Mao, Jinzhe J AU - Zhou, Hongfei AU - Boyne, Michael T AU - Wasserman, Adam M AU - Taylor, Kellie AU - Racoosin, Judith A AU - Patel, Vikram AU - Colatsky, Thomas AD - Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. Electronic address: neil.hartman@fda.hhs.gov. ; Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. ; Division of Pharmaceutical Analysis, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. ; Division of Anesthesia, Analgesia and Addiction Products, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. ; Division of Medication Error Prevention and Analysis, Center for Drug Evaluation and Research, Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD 20993-0002, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 182 EP - 188 VL - 70 IS - 1 KW - Anesthetics, Local KW - 0 KW - Aniline Compounds KW - 2,6-xylidine KW - 4FT62OX08D KW - Methemoglobin KW - 9008-37-1 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Lidocaine KW - 98PI200987 KW - Benzocaine KW - U3RSY48JW5 KW - Index Medicus KW - Methemoglobinemia KW - Xylidine KW - Benzocaine hydroxylamine KW - Humans KW - Methemoglobin -- metabolism KW - In Vitro Techniques KW - Liver -- metabolism KW - Cytochrome P-450 Enzyme System -- metabolism KW - Aniline Compounds -- metabolism KW - Lidocaine -- metabolism KW - Benzocaine -- metabolism KW - Methemoglobinemia -- chemically induced KW - Anesthetics, Local -- toxicity KW - Anesthetics, Local -- metabolism KW - Lidocaine -- toxicity KW - Benzocaine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561973652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=More+methemoglobin+is+produced+by+benzocaine+treatment+than+lidocaine+treatment+in+human+in+vitro+systems.&rft.au=Hartman%2C+Neil+R%3BMao%2C+Jinzhe+J%3BZhou%2C+Hongfei%3BBoyne%2C+Michael+T%3BWasserman%2C+Adam+M%3BTaylor%2C+Kellie%3BRacoosin%2C+Judith+A%3BPatel%2C+Vikram%3BColatsky%2C+Thomas&rft.aulast=Hartman&rft.aufirst=Neil&rft.date=2014-10-01&rft.volume=70&rft.issue=1&rft.spage=182&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.07.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-20 N1 - Date created - 2014-09-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.07.002 ER - TY - JOUR T1 - Public health decisions: actions and consequences. AN - 1561973523; 25092130 AB - The goal of public health is to promote the best possible health for the whole population. Public health issues are numerous and can be unbelievably complex in form, scope, and possible consequence. Most public health decisions involve assessing several different options, weighing the respective benefits and risks of those options, and making difficult decisions that hopefully provide the greatest benefit to the affected populations. Many risk management decisions involve a variety of societal factors which modify risk assessment choices. The purpose of this paper is to point out difficulties in making decisions that impact public health. The intent of such decisions is to improve public health, but as illustrated in the paper, there can be unintended adverse consequences. Such unplanned issues require continued attention and efforts for responsible officials in the protection of environmental public health. This article presents examples of such events, when in the past, it was necessary to assess and regulate a number of potentially hazardous chemicals commonly used as insecticides, gasoline additives, and wood preservatives. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Pohl, H R AU - Jones, D E AU - Holler, J S AU - Murray, H E AD - Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta GA, USA. Electronic address: hpohl@cdc.gov. ; Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta GA, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 363 EP - 369 VL - 70 IS - 1 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Insecticides KW - Wood preservatives KW - Risk management decisions KW - Chemical regulations KW - Gasoline additives KW - Humans KW - Risk Assessment -- methods KW - Decision Making KW - Risk Management -- methods KW - Public Health KW - Hazardous Substances -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561973523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Public+health+decisions%3A+actions+and+consequences.&rft.au=Pohl%2C+H+R%3BJones%2C+D+E%3BHoller%2C+J+S%3BMurray%2C+H+E&rft.aulast=Pohl&rft.aufirst=H&rft.date=2014-10-01&rft.volume=70&rft.issue=1&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.07.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-15 N1 - Date created - 2014-09-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.07.023 ER - TY - JOUR T1 - Staphylococcus aureus hyaluronidase is a CodY-regulated virulence factor. AN - 1561967284; 25069977 AB - Staphylococcus aureus is a Gram-positive pathogen that causes a diverse range of bacterial infections. Invasive S. aureus strains secrete an extensive arsenal of hemolysins, immunomodulators, and exoenzymes to cause disease. Our studies have focused on the secreted enzyme hyaluronidase (HysA), which cleaves the hyaluronic acid polymer at the β-1,4 glycosidic bond. In the study described in this report, we have investigated the regulation and contribution of this enzyme to S. aureus pathogenesis. Using the Nebraska Transposon Mutant Library (NTML), we identified eight insertions that modulate extracellular levels of HysA activity. Insertions in the sigB operon, as well as in genes encoding the global regulators SarA and CodY, significantly increased HysA protein levels and activity. By altering the availability of branched-chain amino acids, we further demonstrated CodY-dependent repression of HysA activity. Additionally, through mutation of the CodY binding box upstream of hysA, the repression of HysA production was lost, suggesting that CodY is a direct repressor of hysA expression. To determine whether HysA is a virulence factor, a ΔhysA mutant of a community-associated methicillin-resistant S. aureus (CA-MRSA) USA300 strain was constructed and found to be attenuated in a neutropenic, murine model of pulmonary infection. Mice infected with this mutant strain exhibited a 4-log-unit reduction in bacterial burden in their lungs, as well as reduced lung pathology and increased levels of pulmonary hyaluronic acid, compared to mice infected with the wild-type, parent strain. Taken together, these results indicate that S. aureus hyaluronidase is a CodY-regulated virulence factor. Copyright © 2014, American Society for Microbiology. All Rights Reserved. JF - Infection and immunity AU - Ibberson, Carolyn B AU - Jones, Crystal L AU - Singh, Shweta AU - Wise, Matthew C AU - Hart, Mark E AU - Zurawski, Daniel V AU - Horswill, Alexander R AD - Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA. ; Department of Wound Infections, Walter Reed Army Institute of Research (WRAIR), Silver Spring, Maryland, USA. ; Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas, USA. ; Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA alex-horswill@uiowa.edu. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 4253 EP - 4264 VL - 82 IS - 10 KW - Bacterial Proteins KW - 0 KW - CodY protein, Staphylococcus aureus KW - Repressor Proteins KW - Virulence Factors KW - Polysaccharide-Lyases KW - EC 4.2.2.- KW - hyaluronate lyase KW - EC 4.2.2.1 KW - Index Medicus KW - Virulence KW - Animals KW - Pneumonia, Staphylococcal -- pathology KW - Disease Models, Animal KW - Mice KW - Bacterial Load KW - Lung -- pathology KW - Histocytochemistry KW - Pneumonia, Staphylococcal -- microbiology KW - Mice, Inbred BALB C KW - Female KW - Lung -- microbiology KW - Gene Expression Regulation, Bacterial KW - Staphylococcus aureus -- genetics KW - Repressor Proteins -- metabolism KW - Bacterial Proteins -- metabolism KW - Staphylococcus aureus -- pathogenicity KW - Polysaccharide-Lyases -- biosynthesis KW - Virulence Factors -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561967284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Staphylococcus+aureus+hyaluronidase+is+a+CodY-regulated+virulence+factor.&rft.au=Ibberson%2C+Carolyn+B%3BJones%2C+Crystal+L%3BSingh%2C+Shweta%3BWise%2C+Matthew+C%3BHart%2C+Mark+E%3BZurawski%2C+Daniel+V%3BHorswill%2C+Alexander+R&rft.aulast=Ibberson&rft.aufirst=Carolyn&rft.date=2014-10-01&rft.volume=82&rft.issue=10&rft.spage=4253&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=1098-5522&rft_id=info:doi/10.1128%2FIAI.01710-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-12 N1 - Date created - 2014-09-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Bacteriol. 2008 Apr;190(7):2257-65 [18156263] J Bacteriol. 2008 Feb;190(4):1224-36 [18083814] J Bacteriol. 2010 Dec;192(24):6357-68 [20935095] Physiol Rev. 2011 Jan;91(1):221-64 [21248167] J Bacteriol. 2011 May;193(9):2332-5 [21378186] FEMS Immunol Med Microbiol. 2011 Jul;62(2):123-39 [21539625] Mol Microbiol. 2011 Aug;81(3):659-75 [21651625] J Bacteriol. 2011 Oct;193(19):5279-91 [21784926] PLoS One. 2011;6(11):e26714 [22096493] Proteomics. 2012 Jan;12(2):263-8 [22106056] Infect Immun. 2012 Apr;80(4):1390-8 [22311922] Microbiol Mol Biol Rev. 2012 Jun;76(2):383-404 [22688817] Infect Immun. 2012 Jul;80(7):2382-9 [22526672] J Phys Chem B. 2012 Sep 13;116(36):11166-72 [22916709] MBio. 2013;4(1):e00537-12 [23404398] Appl Environ Microbiol. 2013 Apr;79(7):2218-24 [23354696] J Bacteriol. 2013 Apr;195(8):1779-88 [23396916] Microbiology. 2013 Apr;159(Pt 4):782-91 [23393148] Infect Immun. 2013 Sep;81(9):3227-38 [23798534] Antimicrob Agents Chemother. 2014;58(3):1332-42 [24342634] J Bacteriol. 2008 Aug;190(15):5265-78 [18539737] Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3958-63 [19237567] Infect Immun. 2009 Apr;77(4):1623-35 [19188357] Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5883-8 [19293374] J Bacteriol. 2009 May;191(9):2953-63 [19251851] Microbiol Mol Biol Rev. 2009 Jun;73(2):233-48 [19487727] Nat Rev Microbiol. 2009 Sep;7(9):629-41 [19680247] J Clin Invest. 2009 Sep;119(9):2464-74 [19729844] PLoS Pathog. 2009 Oct;5(10):e1000643 [19876387] PLoS One. 2010;5(4):e10146 [20418950] J Bacteriol. 2010 Jun;192(11):2861-77 [20363936] Clin Microbiol Rev. 2010 Jul;23(3):616-87 [20610826] EMBO J. 2000 Mar 15;19(6):1228-40 [10716923] FEMS Microbiol Lett. 2000 Feb 15;183(2):201-7 [10675584] PLoS Pathog. 2010;6(8):e1000949 [20711357] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5 [10829079] J Biol Chem. 2001 Nov 2;276(44):41407-16 [11527972] Infect Immun. 2001 Dec;69(12):7851-7 [11705967] Microbiology. 2004 Jun;150(Pt 6):2005-13 [15184586] Rev Infect Dis. 1979 Mar-Apr;1(2):254-62 [232935] FASEB J. 1992 Apr;6(7):2397-404 [1563592] FEMS Microbiol Lett. 1992 Jul 1;73(1-2):133-8 [1521761] FEMS Microbiol Lett. 1995 Jul 15;130(1):81-5 [7557301] Acta Ophthalmol Scand. 1996 Dec;74(6):566-8 [9017043] J Intern Med. 1997 Jul;242(1):27-33 [9260563] N Engl J Med. 1998 Aug 20;339(8):520-32 [9709046] J Pathol Bacteriol. 1953 Oct;66(2):545-51 [13118461] J Gen Microbiol. 1954 Apr;10(2):209-20 [13152332] J Gen Microbiol. 1957 Feb;16(1):22-37 [13406217] J Exp Med. 2005 May 16;201(10):1669-76 [15897280] Infect Immun. 2006 Jan;74(1):40-8 [16368955] Am J Respir Cell Mol Biol. 2006 Feb;34(2):135-41 [16195536] Lancet. 2006 Mar 4;367(9512):731-9 [16517273] Clin Infect Dis. 2007 Nov 1;45(9):1132-40 [17918074] Clin Infect Dis. 2008 Jun 1;46 Suppl 5:S350-9 [18462090] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/IAI.01710-14 ER - TY - JOUR T1 - New small-molecule inhibitors effectively blocking picornavirus replication. AN - 1561131239; 25008939 AB - Few drugs targeting picornaviruses are available, making the discovery of antivirals a high priority. Here, we identified and characterized three compounds from a library of kinase inhibitors that block replication of poliovirus, coxsackievirus B3, and encephalomyocarditis virus. Using an in vitro translation-replication system, we showed that these drugs inhibit different stages of the poliovirus life cycle. A4(1) inhibited both the formation and functioning of the replication complexes, while E5(1) and E7(2) were most effective during the formation but not the functioning step. Neither of the compounds significantly inhibited VPg uridylylation. Poliovirus resistant to E7(2) had a G5318A mutation in the 3A protein. This mutation was previously found to confer resistance to enviroxime-like compounds, which target a phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ)-dependent step in viral replication. Analysis of host protein recruitment showed that E7(2) reduced the amount of GBF1 on the replication complexes; however, the level of PI4KIIIβ remained intact. E7(2) as well as another enviroxime-like compound, GW5074, interfered with viral polyprotein processing affecting both 3C- and 2A-dependent cleavages, and the resistant G5318A mutation partially rescued this defect. Moreover, E7(2) induced abnormal recruitment to membranes of the viral proteins; thus, enviroxime-like compounds likely severely compromise the interaction of the viral polyprotein with membranes. A4(1) demonstrated partial protection from paralysis in a murine model of poliomyelitis. Multiple attempts to isolate resistant mutants in the presence of A4(1) or E5(1) were unsuccessful, showing that effective broad-spectrum antivirals could be developed on the basis of these compounds. Diverse picornaviruses can trigger multiple human maladies, yet currently, only hepatitis A virus and poliovirus can be controlled with vaccination. The development of antipicornavirus therapeutics is also facing significant difficulties because these viruses readily generate resistance to compounds targeting either viral or cellular factors. Here, we describe three novel compounds that effectively block replication of distantly related picornaviruses with minimal toxicity to cells. The compounds prevent viral RNA replication after the synthesis of the uridylylated VPg primer. Importantly, two of the inhibitors are strongly refractory to the emergence of resistant mutants, making them promising candidates for further broad-spectrum therapeutic development. Evaluation of one of the compounds in an in vivo model of poliomyelitis demonstrated partial protection from the onset of paralysis. Copyright © 2014, American Society for Microbiology. All Rights Reserved. JF - Journal of virology AU - Ford Siltz, Lauren A AU - Viktorova, Ekaterina G AU - Zhang, Ben AU - Kouiavskaia, Diana AU - Dragunsky, Eugenia AU - Chumakov, Konstantin AU - Isaacs, Lyle AU - Belov, George A AD - Department of Veterinary Medicine, University of Maryland, and Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, USA. ; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, USA. ; Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, FDA, Rockville, Maryland, USA. ; Department of Veterinary Medicine, University of Maryland, and Virginia-Maryland Regional College of Veterinary Medicine, College Park, Maryland, USA gbelov@umd.edu. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 11091 EP - 11107 VL - 88 IS - 19 KW - Antiviral Agents KW - 0 KW - Polyproteins KW - Small Molecule Libraries KW - Viral Proteins KW - 1-Phosphatidylinositol 4-Kinase KW - EC 2.7.1.67 KW - Index Medicus KW - Animals KW - Gene Expression Regulation, Viral KW - HeLa Cells KW - Humans KW - Disease Models, Animal KW - Mice KW - Polyproteins -- metabolism KW - Structure-Activity Relationship KW - 1-Phosphatidylinositol 4-Kinase -- genetics KW - Polyproteins -- antagonists & inhibitors KW - Encephalomyocarditis virus -- drug effects KW - 1-Phosphatidylinositol 4-Kinase -- metabolism KW - Enterovirus B, Human -- metabolism KW - Enterovirus B, Human -- genetics KW - Enterovirus B, Human -- drug effects KW - Polyproteins -- genetics KW - Mutation KW - 1-Phosphatidylinositol 4-Kinase -- antagonists & inhibitors KW - Signal Transduction KW - Cell-Free System KW - Encephalomyocarditis virus -- genetics KW - Encephalomyocarditis virus -- metabolism KW - Viral Proteins -- genetics KW - Poliomyelitis -- virology KW - Poliovirus -- growth & development KW - Small Molecule Libraries -- chemistry KW - Poliovirus -- drug effects KW - Virus Replication -- drug effects KW - Small Molecule Libraries -- pharmacology KW - Antiviral Agents -- chemistry KW - Antiviral Agents -- pharmacology KW - Poliovirus -- genetics KW - Viral Proteins -- metabolism KW - Viral Proteins -- antagonists & inhibitors KW - Poliomyelitis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561131239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=New+small-molecule+inhibitors+effectively+blocking+picornavirus+replication.&rft.au=Ford+Siltz%2C+Lauren+A%3BViktorova%2C+Ekaterina+G%3BZhang%2C+Ben%3BKouiavskaia%2C+Diana%3BDragunsky%2C+Eugenia%3BChumakov%2C+Konstantin%3BIsaacs%2C+Lyle%3BBelov%2C+George+A&rft.aulast=Ford+Siltz&rft.aufirst=Lauren&rft.date=2014-10-01&rft.volume=88&rft.issue=19&rft.spage=11091&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=1098-5514&rft_id=info:doi/10.1128%2FJVI.01877-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-11 N1 - Date created - 2014-09-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Virol. 2004 Apr;78(7):3378-86 [15016860] J Virol. 2003 Dec;77(23):12679-91 [14610190] J Virol. 1968 Sep;2(9):859-64 [4302186] J Virol. 1975 Apr;15(4):1033-6 [163914] Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):951-5 [1846972] J Virol. 1992 Apr;66(4):1985-94 [1312615] Virology. 1992 Nov;191(1):166-75 [1329315] Arch Virol. 1994;139(3-4):351-63 [7832641] J Virol. 1995 Sep;69(9):5516-27 [7636997] J Virol. 1996 Jul;70(7):4854-7 [8676522] J Virol. 1997 Nov;71(11):8482-9 [9343205] J Virol. 1998 Aug;72(8):6456-64 [9658088] J Biol Chem. 1999 Mar 12;274(11):6992-7001 [10066753] Circulation. 2005 Feb 22;111(7):887-93 [15699250] Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5998-6003 [15837920] J Virol. 2005 Jun;79(11):7207-16 [15890959] Clin Microbiol Rev. 2006 Jan;19(1):80-94 [16418524] Dev Cell. 2006 Aug;11(2):191-201 [16890159] J Virol. 2007 Jan;81(2):558-67 [17079330] Cancer Cell. 2003 Dec;4(6):463-76 [14706338] Genes Dev. 2007 Jan 15;21(2):195-205 [17234885] J Virol. 2007 May;81(10):5238-45 [17329336] Antiviral Res. 2008 Sep;79(3):179-87 [18513807] PLoS Pathog. 2008 Nov;4(11):e1000216 [19023417] J Gen Virol. 2009 Aug;90(Pt 8):1869-79 [19439558] J Virol. 2009 Nov;83(22):11940-9 [19740986] J Virol. 2009 Nov;83(22):11665-72 [19740993] Cell. 2010 May 28;141(5):799-811 [20510927] J Gen Virol. 2010 Nov;91(Pt 11):2734-44 [20660150] Curr Top Microbiol Immunol. 2010;347:241-62 [20549474] BMJ. 2011;342:d35 [21292721] J Virol. 2011 Mar;85(5):2364-72 [21177810] J Virol. 2012 Jan;86(1):302-12 [22072780] Biochem Pharmacol. 2012 Jan 15;83(2):185-92 [21889497] EMBO J. 2012 Feb 1;31(3):754-66 [22124328] J Virol. 2012 Apr;86(7):3605-16 [22258260] Nat Chem. 2012 Jun;4(6):503-10 [22614387] Cell Res. 2012 Nov;22(11):1576-92 [22945356] J Virol. 2013 Apr;87(8):4252-60 [23365445] Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81 [23896472] J Virol. 2013 Oct;87(20):11031-46 [23926333] J Virol. 2014 Mar;88(5):2725-36 [24352456] J Virol. 1999 Dec;73(12):10104-12 [10559325] J Virol. 2000 Jul;74(14):6394-400 [10864650] Am J Med. 2002 Apr 22;112 Suppl 6A:42S-49S [11955459] J Virol. 2002 Nov;76(21):11113-22 [12368353] J Virol. 2003 Jan;77(1):45-56 [12477809] Arch Intern Med. 2003 Feb 24;163(4):487-94 [12588210] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7289-94 [12754380] J Virol. 2003 Nov;77(21):11408-16 [14557626] J Med Chem. 2003 Nov 6;46(23):4910-25 [14584942] Cancer Res. 2004 Jul 1;64(13):4394-9 [15231645] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/JVI.01877-14 ER - TY - JOUR T1 - A case-control study of occupational exposure to metalworking fluids and bladder cancer risk among men. AN - 1561130152; 25201311 AB - Metalworking has been associated with an excess risk of bladder cancer in over 20 studies. Metalworking fluids (MWFs) are suspected as the responsible exposure, but epidemiological data are limited. We investigated this association among men in the New England Bladder Cancer Study using state-of-the-art, quantitative exposure assessment methods. Cases (n=895) and population controls (n=1031) provided occupational histories during personal interviews. For selected jobs, exposure-oriented modules were administered to collect information on use of three MWF types: (1) straight (mineral oil, additives), (2) soluble (mineral oil, water, additives) and (3) synthetic (water, organics, additives) or semisynthetic (hybrid of soluble and synthetic). We computed ORs and 95% CIs relating bladder cancer risk to a variety of exposure metrics, adjusting for smoking and other factors. Non-metalworkers who had held jobs with possible exposure to mineral oil were analysed separately. Bladder cancer risk was elevated among men who reported using straight MWFs (OR=1.7, 95% CI 1.1 to 2.8); risk increased monotonically with increasing cumulative exposure (p=0.041). Use of soluble MWFs was associated with a 50% increased risk (95% CI 0.96 to 2.5). ORs were non-significantly elevated for synthetic/semisynthetic MWFs based on a small number of exposed men. Non-metalworkers holding jobs with possible exposure to mineral oil had a 40% increased risk (95% CI 1.1 to 1.8). Exposure to straight MWFs was associated with a significantly increased bladder cancer risk, as was employment in non-metalworking jobs with possible exposure to mineral oil. These findings strengthen prior evidence for mineral oil as a bladder carcinogen. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Occupational and environmental medicine AU - Colt, Joanne S AU - Friesen, Melissa C AU - Stewart, Patricia A AU - Donguk, Park AU - Johnson, Alison AU - Schwenn, Molly AU - Karagas, Margaret R AU - Armenti, Karla AU - Waddell, Richard AU - Verrill, Castine AU - Ward, Mary H AU - Freeman, Laura E Beane AU - Moore, Lee E AU - Koutros, Stella AU - Baris, Dalsu AU - Silverman, Debra T AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. ; Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Stewart Exposure Assessments, LLC, Arlington, Virginia, USA. ; Korea National Open University, Seoul, Korea. ; Vermont Cancer Registry, Burlington, Vermont, USA. ; Maine Cancer Registry, Augusta, Maine, USA. ; Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. ; New Hampshire Department of Health and Human Services, Concord, New Hampshire, USA. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 667 EP - 674 VL - 71 IS - 10 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - New England -- epidemiology KW - Male KW - Occupational Exposure KW - Urinary Bladder Neoplasms -- epidemiology KW - Metallurgy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561130152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=A+case-control+study+of+occupational+exposure+to+metalworking+fluids+and+bladder+cancer+risk+among+men.&rft.au=Colt%2C+Joanne+S%3BFriesen%2C+Melissa+C%3BStewart%2C+Patricia+A%3BDonguk%2C+Park%3BJohnson%2C+Alison%3BSchwenn%2C+Molly%3BKaragas%2C+Margaret+R%3BArmenti%2C+Karla%3BWaddell%2C+Richard%3BVerrill%2C+Castine%3BWard%2C+Mary+H%3BFreeman%2C+Laura+E+Beane%3BMoore%2C+Lee+E%3BKoutros%2C+Stella%3BBaris%2C+Dalsu%3BSilverman%2C+Debra+T&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2014-10-01&rft.volume=71&rft.issue=10&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foemed-2013-102056 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-29 N1 - Date created - 2014-09-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1983 Feb;70(2):237-45 [6571931] Scand J Work Environ Health. 1983 Oct;9(5):449-50 [6673102] IARC Monogr Eval Carcinog Risk Chem Hum. 1984 Apr;33:1-222 [6590450] Cancer. 1986 Jan 15;57(2):362-7 [3942969] Int J Cancer. 1987 Mar 15;39(3):287-92 [3818120] Am J Epidemiol. 1987 Aug;126(2):247-57 [3605053] Am J Public Health. 1987 Oct;77(10):1298-300 [3631363] Cancer Res. 1987 Dec 15;47(24 Pt 1):6763-6 [3677105] Int J Cancer. 1987 Dec 15;40(6):734-40 [3692621] Scand J Work Environ Health. 1987 Dec;13(6):493-504 [3433051] Arch Environ Health. 1987 Nov-Dec;42(6):361-6 [3439814] Int J Cancer. 1988 Mar 15;41(3):371-9 [3346100] J Natl Cancer Inst. 1989 Oct 4;81(19):1472-80 [2778834] Br J Cancer. 1992 Sep;66(3):568-78 [1520596] Am J Ind Med. 2000 Jul;38(1):90-8 [10861770] Am J Ind Med. 2000 Oct;38(4):410-6 [10982981] J Occup Environ Med. 2002 Jul;44(7):685-91 [12134533] Scand J Work Environ Health. 2002 Dec;28(6):371-85 [12539797] Appl Occup Environ Hyg. 2003 Nov;18(11):855-64 [14555438] Appl Occup Environ Hyg. 2003 Nov;18(11):902-12 [14555443] Appl Occup Environ Hyg. 2003 Nov;18(11):913-20 [14555444] Cancer Causes Control. 2003 Dec;14(10):907-14 [14750529] Cancer Causes Control. 2004 Oct;15(8):759-69 [15456989] J Natl Cancer Inst. 1980 Apr;64(4):701-13 [6928984] Scand J Work Environ Health. 1992 Dec;18(6):351-60 [1485160] Int J Epidemiol. 1993 Jun;22(3):403-11 [8359955] Occup Environ Med. 1995 Aug;52(8):557-8 [7663646] Occup Environ Med. 1996 Jan;53(1):6-10 [8563860] Am J Ind Med. 1996 Dec;30(6):664-73 [8914713] Occup Environ Med. 1997 Jun;54(6):443-51 [9245952] Am J Ind Med. 1998 Mar;33(3):282-92 [9481427] J Occup Environ Med. 2005 Aug;47(8):854-8 [16093936] Am J Ind Med. 2005 Oct;48(4):249-58 [16167347] Lancet Oncol. 2005 Dec;6(12):931-2 [16353404] Occup Environ Med. 2007 Aug;64(8):520-6 [17332134] Ann Occup Hyg. 2009 Apr;53(3):271-88 [19329796] Am J Epidemiol. 2009 Jun 15;169(12):1471-8 [19414495] J Occup Environ Hyg. 2009 Sep;6(9):530-41 [19544177] Occup Environ Med. 2011 Apr;68(4):239-49 [20864470] Am J Ind Med. 2011 Jun;54(6):450-60 [21328414] IARC Monogr Eval Carcinog Risks Hum. 2013;101:9-549 [24772663] Am J Ind Med. 2014 Aug;57(8):915-27 [25060071] J Occup Environ Hyg. 2014;11(11):757-70 [25256317] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/oemed-2013-102056 ER - TY - JOUR T1 - Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer. AN - 1561035527; 25097189 AB - The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is being considered as a potential therapeutic target for neuropsychiatric disorders. Previous studies suggested that this heteromer could be involved in the ability of D3R agonists to potentiate locomotor activation induced by D1R agonists. It has also been postulated that its overexpression plays a role in L-dopa-induced dyskinesia and in drug addiction. However, little is known about its biochemical properties. By combining bioluminescence resonance energy transfer, bimolecular complementation techniques, and cell-signaling experiments in transfected cells, evidence was obtained for a tetrameric stoichiometry of the D1R-D3R heteromer, constituted by two interacting D1R and D3R homodimers coupled to Gs and Gi proteins, respectively. Coactivation of both receptors led to the canonical negative interaction at the level of adenylyl cyclase signaling, to a strong recruitment of β-arrestin-1, and to a positive cross talk of D1R and D3R agonists at the level of mitogen-activated protein kinase (MAPK) signaling. Furthermore, D1R or D3R antagonists counteracted β-arrestin-1 recruitment and MAPK activation induced by D3R and D1R agonists, respectively (cross-antagonism). Positive cross talk and cross-antagonism at the MAPK level were counteracted by specific synthetic peptides with amino acid sequences corresponding to D1R transmembrane (TM) domains TM5 and TM6, which also selectively modified the quaternary structure of the D1R-D3R heteromer, as demonstrated by complementation of hemiproteins of yellow fluorescence protein fused to D1R and D3R. These results demonstrate functional selectivity of allosteric modulations within the D1R-D3R heteromer, which can be involved with the reported behavioral synergism of D1R and D3R agonists. U.S. Government work not protected by U.S. copyright. JF - Molecular pharmacology AU - Guitart, Xavier AU - Navarro, Gemma AU - Moreno, Estefania AU - Yano, Hideaki AU - Cai, Ning-Sheng AU - Sánchez-Soto, Marta AU - Kumar-Barodia, Sandeep AU - Naidu, Yamini T AU - Mallol, Josefa AU - Cortés, Antoni AU - Lluís, Carme AU - Canela, Enric I AU - Casadó, Vicent AU - McCormick, Peter J AU - Ferré, Sergi AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (X.G., H.Y., N.-S.C., M.S.-S., S.K.-B., Y.T.N., S.F.); Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (G.N., E.M., J.M., A.C., C.L., E.I.C., V.C., P.J.M.); and School of Pharmacy, University of East Anglia, Norwich, United Kingdom (P.J.M.). ; National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland (X.G., H.Y., N.-S.C., M.S.-S., S.K.-B., Y.T.N., S.F.); Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas and Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Barcelona, Barcelona, Spain (G.N., E.M., J.M., A.C., C.L., E.I.C., V.C., P.J.M.); and School of Pharmacy, University of East Anglia, Norwich, United Kingdom (P.J.M.) sferre@intra.nida.nih.gov. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 417 EP - 429 VL - 86 IS - 4 KW - ARRB1 protein, human KW - 0 KW - Arrestins KW - DRD1 protein, human KW - DRD3 protein, human KW - Dopamine Agonists KW - Receptors, Dopamine D1 KW - Receptors, Dopamine D3 KW - beta-Arrestin 1 KW - beta-Arrestins KW - GTP-Binding Protein alpha Subunits, Gi-Go KW - EC 3.6.5.1 KW - GTP-Binding Protein alpha Subunits, Gs KW - Adenylyl Cyclases KW - EC 4.6.1.1 KW - Index Medicus KW - GTP-Binding Protein alpha Subunits, Gi-Go -- metabolism KW - MAP Kinase Signaling System KW - Dopamine Agonists -- pharmacology KW - Humans KW - HEK293 Cells KW - Adenylyl Cyclases -- metabolism KW - Allosteric Regulation KW - GTP-Binding Protein alpha Subunits, Gs -- metabolism KW - Protein Multimerization KW - Protein Binding KW - Arrestins -- metabolism KW - Receptors, Dopamine D3 -- agonists KW - Receptors, Dopamine D3 -- metabolism KW - Receptors, Dopamine D1 -- agonists KW - Receptors, Dopamine D1 -- chemistry KW - Receptors, Dopamine D3 -- chemistry KW - Allosteric Site KW - Receptors, Dopamine D1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561035527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Functional+selectivity+of+allosteric+interactions+within+G+protein-coupled+receptor+oligomers%3A+the+dopamine+D1-D3+receptor+heterotetramer.&rft.au=Guitart%2C+Xavier%3BNavarro%2C+Gemma%3BMoreno%2C+Estefania%3BYano%2C+Hideaki%3BCai%2C+Ning-Sheng%3BS%C3%A1nchez-Soto%2C+Marta%3BKumar-Barodia%2C+Sandeep%3BNaidu%2C+Yamini+T%3BMallol%2C+Josefa%3BCort%C3%A9s%2C+Antoni%3BLlu%C3%ADs%2C+Carme%3BCanela%2C+Enric+I%3BCasad%C3%B3%2C+Vicent%3BMcCormick%2C+Peter+J%3BFerr%C3%A9%2C+Sergi&rft.aulast=Guitart&rft.aufirst=Xavier&rft.date=2014-10-01&rft.volume=86&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=1521-0111&rft_id=info:doi/10.1124%2Fmol.114.093096 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-07 N1 - Date created - 2014-09-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Neurosci. 2002 Sep 15;22(18):7931-40 [12223546] J Neurosci. 2014 Mar 5;34(10):3545-58 [24599455] J Mol Biol. 2003 Jun 13;329(4):815-29 [12787680] J Biol Chem. 1996 Jul 5;271(27):16384-92 [8663163] J Neurosci. 1996 Oct 1;16(19):6100-6 [8815892] Mol Pharmacol. 1997 Sep;52(3):508-14 [9281614] Nat Rev Mol Cell Biol. 2006 Jun;7(6):449-56 [16625152] Pharmacol Ther. 2007 Dec;116(3):343-54 [17935788] Mol Pharmacol. 2008 Jul;74(1):59-69 [18424554] Nat Methods. 2008 Aug;5(8):727-33 [18587404] J Biol Chem. 2008 Sep 19;283(38):26016-25 [18644790] EMBO J. 2008 Sep 3;27(17):2293-304 [18668123] Neuropsychopharmacology. 2009 Mar;34(4):972-86 [18800071] Nat Chem Biol. 2009 Mar;5(3):131-4 [19219011] Br J Pharmacol. 2009 May;157(1):64-75 [19413572] Methods Mol Biol. 2009;574:215-34 [19685312] Dev Cell. 2009 Oct;17(4):443-58 [19853559] Curr Opin Pharmacol. 2010 Feb;10(1):87-92 [19837631] CNS Neurol Disord Drug Targets. 2010 Nov;9(5):596-600 [20632968] Biochem Biophys Res Commun. 2010 Nov 26;402(4):801-7 [21040702] Nat Med. 2010 Dec;16(12):1393-5 [21113156] Neuron. 2011 Jan 13;69(1):120-31 [21220103] PLoS One. 2011;6(1):e16088 [21264319] Nat Chem Biol. 2011 Sep;7(9):624-30 [21785426] Trends Pharmacol Sci. 2011 Sep;32(9):514-20 [21715028] Annu Rev Pharmacol Toxicol. 2012;52:179-97 [21942629] Mol Psychiatry. 2012 Jun;17(6):650-62 [21844870] Mol Pharmacol. 2013 Jul;84(1):158-69 [23632086] Pharmacol Rev. 2014;66(2):413-34 [24515647] J Biol Chem. 2003 Feb 14;278(7):4385-8 [12496294] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1124/mol.114.093096 ER - TY - JOUR T1 - Pleiotropic and epistatic behavior of a ring-hydroxylating oxygenase system in the polycyclic aromatic hydrocarbon metabolic network from Mycobacterium vanbaalenii PYR-1. AN - 1560582715; 25070740 AB - Despite the considerable knowledge of bacterial high-molecular-weight (HMW) polycyclic aromatic hydrocarbon (PAH) metabolism, the key enzyme(s) and its pleiotropic and epistatic behavior(s) responsible for low-molecular-weight (LMW) PAHs in HMW PAH-metabolic networks remain poorly understood. In this study, a phenotype-based strategy, coupled with a spray plate method, selected a Mycobacterium vanbaalenii PYR-1 mutant (6G11) that degrades HMW PAHs but not LMW PAHs. Sequence analysis determined that the mutant was defective in pdoA2, encoding an aromatic ring-hydroxylating oxygenase (RHO). A series of metabolic comparisons using high-performance liquid chromatography (HPLC) analysis revealed that the mutant had a lower rate of degradation of fluorene, anthracene, and pyrene. Unlike the wild type, the mutant did not produce a color change in culture media containing fluorene, phenanthrene, and fluoranthene. An Escherichia coli expression experiment confirmed the ability of the Pdo system to oxidize biphenyl, the LMW PAHs naphthalene, phenanthrene, anthracene, and fluorene, and the HMW PAHs pyrene, fluoranthene, and benzo[a]pyrene, with the highest enzymatic activity directed toward three-ring PAHs. Structure analysis and PAH substrate docking simulations of the Pdo substrate-binding pocket rationalized the experimentally observed metabolic versatility on a molecular scale. Using information obtained in this study and from previous work, we constructed an RHO-centric functional map, allowing pleiotropic and epistatic enzymatic explanation of PAH metabolism. Taking the findings together, the Pdo system is an RHO system with the pleiotropic responsibility of LMW PAH-centric hydroxylation, and its epistatic functional contribution is also crucial for the metabolic quality and quantity of the PAH-MN. Copyright © 2014, American Society for Microbiology. All Rights Reserved. JF - Journal of bacteriology AU - Kweon, Ohgew AU - Kim, Seong-Jae AU - Kim, Dae-Wi AU - Kim, Jeong Myeong AU - Kim, Hyun-lee AU - Ahn, Youngbeom AU - Sutherland, John B AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research/FDA, Jefferson, Arkansas, USA. ; Department of Biotechnology (BK21 Program) and Institute of Microbiomics, Chung-Ang University, Anseong, Republic of Korea. ; Division of Microbiology, National Center for Toxicological Research/FDA, Jefferson, Arkansas, USA carl.cerniglia@fda.hhs.gov. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 3503 EP - 3515 VL - 196 IS - 19 KW - Bacterial Proteins KW - 0 KW - Polycyclic Aromatic Hydrocarbons KW - Oxygenases KW - EC 1.13.- KW - Index Medicus KW - Substrate Specificity KW - Molecular Weight KW - Mycobacterium -- chemistry KW - Mycobacterium -- genetics KW - Bacterial Proteins -- genetics KW - Oxygenases -- metabolism KW - Bacterial Proteins -- chemistry KW - Mycobacterium -- metabolism KW - Bacterial Proteins -- metabolism KW - Oxygenases -- genetics KW - Polycyclic Aromatic Hydrocarbons -- metabolism KW - Polycyclic Aromatic Hydrocarbons -- chemistry KW - Mycobacterium -- enzymology KW - Oxygenases -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560582715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bacteriology&rft.atitle=Pleiotropic+and+epistatic+behavior+of+a+ring-hydroxylating+oxygenase+system+in+the+polycyclic+aromatic+hydrocarbon+metabolic+network+from+Mycobacterium+vanbaalenii+PYR-1.&rft.au=Kweon%2C+Ohgew%3BKim%2C+Seong-Jae%3BKim%2C+Dae-Wi%3BKim%2C+Jeong+Myeong%3BKim%2C+Hyun-lee%3BAhn%2C+Youngbeom%3BSutherland%2C+John+B%3BCerniglia%2C+Carl+E&rft.aulast=Kweon&rft.aufirst=Ohgew&rft.date=2014-10-01&rft.volume=196&rft.issue=19&rft.spage=3503&rft.isbn=&rft.btitle=&rft.title=Journal+of+bacteriology&rft.issn=1098-5530&rft_id=info:doi/10.1128%2FJB.01945-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-27 N1 - Date created - 2014-09-05 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - 1WW9; PDB; 2B24; 2CKF; 1O7G; 1ULJ N1 - SuppNotes - Cited By: J Bacteriol. 2000 Apr;182(8):2059-67 [10735846] Appl Environ Microbiol. 2012 May;78(10):3715-23 [22407691] Appl Environ Microbiol. 2001 Aug;67(8):3577-85 [11472934] Science. 2001 Oct 5;294(5540):93-6 [11588250] Appl Microbiol Biotechnol. 2002 Mar;58(3):364-9 [11935189] Int J Syst Evol Microbiol. 2002 Nov;52(Pt 6):1997-2002 [12508859] Appl Environ Microbiol. 2003 Jan;69(1):186-90 [12513994] Science. 2003 Feb 14;299(5609):1039-42 [12586937] J Bacteriol. 2003 Jul;185(13):3828-41 [12813077] Appl Environ Microbiol. 2004 Jan;70(1):340-5 [14711661] Biochem Biophys Res Commun. 2004 Sep 10;322(1):133-46 [15313184] J Mol Biol. 2004 Sep 17;342(3):1041-52 [15342255] Adv Appl Microbiol. 1984;30:31-71 [6442534] Appl Environ Microbiol. 1988 Jun;54(6):1612-4 [3415226] Appl Environ Microbiol. 1988 Oct;54(10):2415-23 [2462407] Appl Environ Microbiol. 1988 Oct;54(10):2549-55 [3202633] Appl Environ Microbiol. 1988 Oct;54(10):2556-65 [3202634] Arch Microbiol. 1991;156(3):223-30 [1953305] Biodegradation. 1990;1(4):283-90 [1368473] Appl Environ Microbiol. 1993 Mar;59(3):800-6 [8481006] Appl Environ Microbiol. 1997 Mar;63(3):819-26 [9055403] J Bacteriol. 1999 May;181(10):3105-13 [10322011] J Chromatogr A. 1999 Sep 10;855(2):501-14 [10519088] Appl Environ Microbiol. 2004 Nov;70(11):6714-25 [15528538] Proteomics. 2004 Dec;4(12):3899-908 [15540208] J Ind Microbiol Biotechnol. 2004 Dec;31(11):507-16 [15549609] Appl Microbiol Biotechnol. 2005 Apr;67(2):275-85 [15592827] Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W363-7 [15980490] J Mol Biol. 2005 Aug 12;351(2):355-70 [16005887] J Bacteriol. 2005 Nov;187(21):7222-31 [16237006] Bioinformatics. 2006 Jan 15;22(2):195-201 [16301204] Appl Environ Microbiol. 2006 Feb;72(2):1045-54 [16461648] Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W116-8 [16844972] Biochem Biophys Res Commun. 2007 Jan 26;352(4):861-6 [17157819] J Bacteriol. 2007 Jan;189(2):464-72 [17085566] J Bacteriol. 2007 Jul;189(13):4635-47 [17449607] BMC Biochem. 2008;9:11 [18387195] Biodegradation. 2008 Nov;19(6):859-81 [18421421] J Hazard Mater. 2009 Sep 30;169(1-3):1-15 [19442441] MBio. 2010;1(2). pii: e00135-10. doi: 10.1128/mBio.00135-10 [20714442] Environ Microbiol. 2010 Dec;12(12):3089-104 [20860734] Microb Biotechnol. 2010 Mar;3(2):136-64 [21255317] BMC Bioinformatics. 2011;12 Suppl 1:S33 [21342564] J Agric Food Chem. 2011 Apr 13;59(7):2876-82 [20961044] J Bacteriol. 2011 Sep;193(17):4326-37 [21725022] Appl Environ Microbiol. 2001 Apr;67(4):1476-83 [11282593] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/JB.01945-14 ER - TY - JOUR T1 - Propentophylline increases striatal dopamine release but dampens methamphetamine-induced dopamine dynamics: A microdialysis study. AN - 1559617861; 25049173 AB - While there are currently no medications approved for methamphetamine (METH) addiction, it has been shown that propentofylline (PPF), an atypical methylxanthine, can suppress the rewarding effects of methamphetamine (METH) in mice. This experiment studied the interactions of PPF with METH in striatal dopaminergic transmission. Herein, the impact of PPF (10-40mM, intrastriatally perfused (80min) on the effect of METH (5mg/kg, i.p.) on striatal dopamine (DA) release was evaluated using brain microdialysis in Sprague-Dawley adult rats. METH was injected at the 60min time point of the 80min PPF perfusion. The extracellular levels of DA and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were determined using high performance liquid chromatography with electrochemical detection (HPLC-ED). PPF induced a concentration-dependent increase in DA release beginning 30min after the onset of PPF perfusion. DA peak levels evoked by 40mM PPF were similar to those induced by 5mg/kg METH i.p. Only the highest concentration of PPF decreased the METH-induced DA peak (circa 70%). The significant decreases in extracellular levels of DOPAC and HVA evoked by METH were partially blocked by 10 and 20mM PPF. Although 40mM of PPF also partially blocked the METH-induced DOPAC decrease, it completely blocked HVA depletion after a transient increase in HVA levels in METH-treated rats. Data indicates for the first time that while PPF increases presynaptic striatal DA dynamics it attenuates METH-induced striatal DA release and metabolism. Published by Elsevier Ltd. JF - Neurochemistry international AU - Gough, B AU - Pereira, F C AU - Fontes Ribeiro, C A AU - Ali, S F AU - Binienda, Z K AD - Div. of Neurotoxicology, NCTR/FDA, Jefferson, AR, USA. ; Farmacologia e Terapêutica Experimental/IBILI, Faculdade de Medicina da Univ. de Coimbra, Coimbra, Portugal. Electronic address: fredcp@ci.uc.pt. ; Farmacologia e Terapêutica Experimental/IBILI, Faculdade de Medicina da Univ. de Coimbra, Coimbra, Portugal. ; Div. of Neurotoxicology, NCTR/FDA, Jefferson, AR, USA. Electronic address: zbigniew.binienda@fda.hhs.gov. Y1 - 2014/10// PY - 2014 DA - October 2014 SP - 109 EP - 113 VL - 76 KW - Xanthines KW - 0 KW - Methamphetamine KW - 44RAL3456C KW - propentofylline KW - 5RTA398U4H KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Propentofylline KW - Caudate nucleus KW - In vivo microdialysis KW - Rats KW - Microdialysis KW - Animals KW - Rats, Sprague-Dawley KW - Male KW - Chromatography, High Pressure Liquid KW - Corpus Striatum -- metabolism KW - Methamphetamine -- pharmacology KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Xanthines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1559617861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=Propentophylline+increases+striatal+dopamine+release+but+dampens+methamphetamine-induced+dopamine+dynamics%3A+A+microdialysis+study.&rft.au=Gough%2C+B%3BPereira%2C+F+C%3BFontes+Ribeiro%2C+C+A%3BAli%2C+S+F%3BBinienda%2C+Z+K&rft.aulast=Gough&rft.aufirst=B&rft.date=2014-10-01&rft.volume=76&rft.issue=&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=1872-9754&rft_id=info:doi/10.1016%2Fj.neuint.2014.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-15 N1 - Date created - 2014-09-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuint.2014.07.003 ER - TY - JOUR T1 - The risk of amyotrophic lateral sclerosis after cancer in U.S. elderly adults: A population-based prospective study AN - 1551622049; 20290577 AB - Although epidemiologic studies have examined the risk of amyotrophic lateral sclerosis (ALS) in relation to cancer, none have been large population-based studies using incident ALS and adjusting for medical surveillance. Addressing those limitations, all first primary cancer cases from the Surveillance, Epidemiology and End Results (SEER) Program (1992-2005), linked to Medicare claims data were used. Cases were followed from cancer diagnosis until the earliest date of ALS diagnosis, a break in Medicare claims data, death, age 85 or December 31, 2005. A comparison group from a 5% random Medicare sample in the SEER areas who were cancer-free and censored as above, or until a cancer diagnosis were selected. ALS outcomes were derived from medical claims. The proportional hazards models to estimate ALS hazard ratios (HRs), using age as the time scale, adjusting for sex, race and physician visits, and stratifying the baseline hazard on birth year and SEER registry were used. A total of 303 ALS cases were ascertained in cancer patients (2,154,062 person-years) compared with 246 ALS cases (2,467,634 person-years) in the reference population. There was no overall relationship between cancer and ALS (HR = 0.99; 95% CI = 0.81-1.22), nor by gender or race. Except for an elevated ALS risk in the first year after a leukemia diagnosis, the relationship between site-specific cancers and ALS was null after correcting for multiple comparisons. Having a cancer diagnosis was not associated with an overall risk of incident ALS. The short-term ALS risk after leukemia may reflect screening or reporting errors. What's new? Studies suggest that incident Parkinson's disease and Alzheimer's disease are inversely associated with cancer, but whether the same is true for amyotrophic lateral sclerosis (ALS), another neurodegenerative disease, remains unclear. Here, following examination of incident ALS risk after cancer in a large population-based study that controlled for medical surveillance, no overall association was found to exist between cancer and ALS risk. Heightened screening or reporting errors may be responsible for the detection of elevated ALS risk in the first year following leukemia diagnosis. JF - International Journal of Cancer AU - Freedman, DMichal AU - Wu, Jincao AU - Daugherty, Sarah E AU - Kuncl, Ralph W AU - Enewold, Lindsey R AU - Pfeiffer, Ruth M AD - U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, 9609 Medical Center Drive, Rockville, MD. Y1 - 2014/10// PY - 2014 DA - Oct 2014 SP - 1745 EP - 1750 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 135 IS - 7 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Health risks KW - Leukemia KW - Mortality KW - Age KW - Parkinson's disease KW - Alzheimer's disease KW - Gender KW - Elderly KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551622049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=The+risk+of+amyotrophic+lateral+sclerosis+after+cancer+in+U.S.+elderly+adults%3A+A+population-based+prospective+study&rft.au=Freedman%2C+DMichal%3BWu%2C+Jincao%3BDaugherty%2C+Sarah+E%3BKuncl%2C+Ralph+W%3BEnewold%2C+Lindsey+R%3BPfeiffer%2C+Ruth+M&rft.aulast=Freedman&rft.aufirst=DMichal&rft.date=2014-10-01&rft.volume=135&rft.issue=7&rft.spage=1745&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.28795 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-08-01 N1 - Last updated - 2014-08-21 N1 - SubjectsTermNotLitGenreText - Mortality; Leukemia; Health risks; Age; Parkinson's disease; Gender; Alzheimer's disease; Elderly; Cancer DO - http://dx.doi.org/10.1002/ijc.28795 ER - TY - JOUR T1 - Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures. AN - 1566410011; 25254650 AB - There is a critical need for standard approaches to assess, report and compare the technical performance of genome-scale differential gene expression experiments. Here we assess technical performance with a proposed standard 'dashboard' of metrics derived from analysis of external spike-in RNA control ratio mixtures. These control ratio mixtures with defined abundance ratios enable assessment of diagnostic performance of differentially expressed transcript lists, limit of detection of ratio (LODR) estimates and expression ratio variability and measurement bias. The performance metrics suite is applicable to analysis of a typical experiment, and here we also apply these metrics to evaluate technical performance among laboratories. An interlaboratory study using identical samples shared among 12 laboratories with three different measurement processes demonstrates generally consistent diagnostic power across 11 laboratories. Ratio measurement variability and bias are also comparable among laboratories for the same measurement process. We observe different biases for measurement processes using different mRNA-enrichment protocols. JF - Nature communications AU - Munro, Sarah A AU - Lund, Steven P AU - Pine, P Scott AU - Binder, Hans AU - Clevert, Djork-Arné AU - Conesa, Ana AU - Dopazo, Joaquin AU - Fasold, Mario AU - Hochreiter, Sepp AU - Hong, Huixiao AU - Jafari, Nadereh AU - Kreil, David P AU - Łabaj, Paweł P AU - Li, Sheng AU - Liao, Yang AU - Lin, Simon M AU - Meehan, Joseph AU - Mason, Christopher E AU - Santoyo-Lopez, Javier AU - Setterquist, Robert A AU - Shi, Leming AU - Shi, Wei AU - Smyth, Gordon K AU - Stralis-Pavese, Nancy AU - Su, Zhenqiang AU - Tong, Weida AU - Wang, Charles AU - Wang, Jian AU - Xu, Joshua AU - Ye, Zhan AU - Yang, Yong AU - Yu, Ying AU - Salit, Marc AD - 1] National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, USA [2] Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, California 94305, USA. ; National Institute of Standards and Technology, 100 Bureau Drive, Gaithersburg, Maryland 20899, USA. ; Interdisciplinary Centre for Bioinformatics, University of Leipzig, Härtelstrasse 16-18, 04107 Leipzig, Germany. ; Institute of Bioinformatics, Johannes Kepler University, Altenberger Str. 69, 4040 Linz, Austria. ; Computational Genomics Program, Principe Felipe Research Center, Avd Eduardo Primo Yúfera 3, 46012 Valencia, Spain. ; 1] Computational Genomics Program, Principe Felipe Research Center, Avd Eduardo Primo Yúfera 3, 46012 Valencia, Spain [2] CIBER de Enfermedades Raras (CIBERER) and Functional Genomics Node, INB., Valencia, Spain. ; ecSeq Bioinformatics, Brandvorwerkstrasse 43, 04275 Leipzig, Germany. ; National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, Arkansas 72079, USA. ; Genomics Core Facility, Feinberg School of Medicine, Northwestern University, Tarry building 2-757, 300 E. Superior St. Chicago, Illinois 60611, USA. ; 1] Chair of Bioinformatics, Boku University Vienna, Muthgasse 18, Vienna 1190, Austria [2] University of Warwick, Coventry CV4 7AL, UK. ; Chair of Bioinformatics, Boku University Vienna, Muthgasse 18, Vienna 1190, Austria. ; Department of Physiology and Biophysics, Institute for Computational Biomedicine, Weill Cornell Medical College, 1305 York Avenue, Room Y13-04, Box 140, New York, New York 10021, USA. ; 1] Division of Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia [2] Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia. ; Nationwide Children's Hospital, Columbus, Ohio 43205, USA. ; 1] CIBER de Enfermedades Raras (CIBERER) and Functional Genomics Node, INB., Valencia, Spain [2] Medical Genome Project, Genomics and Bioinformatics Platform of Andalusia, c/ Albert Einstein s/n, 41092 Sevilla, Spain. ; Thermo Fisher Scientific, Research &Development, 2170 Woodward Street, Austin, Texas 78744, USA. ; State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Schools of Life Sciences and Pharmacy, Fudan University, Shanghai 201203, China. ; 1] Division of Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia [2] Department of Computing and Information Systems, The University of Melbourne, Parkville, Victoria 3010, Australia. ; 1] Division of Bioinformatics, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia [2] Department of Mathematics and Statistics, The University of Melbourne, Parkville, Victoria 3010, Australia. ; Division of Microbiology and Molecular Genetics, Center for Genomics, School of Medicine, Loma Linda University, Loma Linda, California 92350, USA. ; Research Informatics, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA. ; Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, 1000 N Oak Avenue, Marshfield, Wisconsin 54449, USA. Y1 - 2014/09/25/ PY - 2014 DA - 2014 Sep 25 SP - 5125 VL - 5 KW - RNA, Messenger KW - 0 KW - Index Medicus KW - Reproducibility of Results KW - Humans KW - Reference Standards KW - RNA, Messenger -- genetics KW - Gene Expression Profiling -- methods KW - Gene Expression Profiling -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566410011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+communications&rft.atitle=Assessing+technical+performance+in+differential+gene+expression+experiments+with+external+spike-in+RNA+control+ratio+mixtures.&rft.au=Munro%2C+Sarah+A%3BLund%2C+Steven+P%3BPine%2C+P+Scott%3BBinder%2C+Hans%3BClevert%2C+Djork-Arn%C3%A9%3BConesa%2C+Ana%3BDopazo%2C+Joaquin%3BFasold%2C+Mario%3BHochreiter%2C+Sepp%3BHong%2C+Huixiao%3BJafari%2C+Nadereh%3BKreil%2C+David+P%3B%C5%81abaj%2C+Pawe%C5%82+P%3BLi%2C+Sheng%3BLiao%2C+Yang%3BLin%2C+Simon+M%3BMeehan%2C+Joseph%3BMason%2C+Christopher+E%3BSantoyo-Lopez%2C+Javier%3BSetterquist%2C+Robert+A%3BShi%2C+Leming%3BShi%2C+Wei%3BSmyth%2C+Gordon+K%3BStralis-Pavese%2C+Nancy%3BSu%2C+Zhenqiang%3BTong%2C+Weida%3BWang%2C+Charles%3BWang%2C+Jian%3BXu%2C+Joshua%3BYe%2C+Zhan%3BYang%2C+Yong%3BYu%2C+Ying%3BSalit%2C+Marc&rft.aulast=Munro&rft.aufirst=Sarah&rft.date=2014-09-25&rft.volume=5&rft.issue=&rft.spage=5125&rft.isbn=&rft.btitle=&rft.title=Nature+communications&rft.issn=2041-1723&rft_id=info:doi/10.1038%2Fncomms6125 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-28 N1 - Date created - 2014-09-26 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - GSE47792; GEO; GSE46876 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/ncomms6125 ER - TY - JOUR T1 - First report of a direct surface plasmon resonance immunosensor for a small molecule seafood toxin. AN - 1562663516; 25117539 AB - Tetrodotoxin (TTX), a small molecular weight neurotoxin, is responsible for poisoning events that traditionally occur from consumption of contaminated puffer fish. Recent studies have shown a growing number of foods contaminated with TTX and a larger number of waters and associated countries where the toxin may occur. The apparent expanding prevalence of TTX supports a growing need for screening assays that can be used to detect potentially harmful food. In the past few years, surface plasmon resonance (SPR) biosensors have been developed for rapid, robust detection of TTX; however, these assays focus on detection of unbound antibody from an inhibition reaction with the toxin. This manuscript introduces the first direct immunoassay for a seafood toxin, specifically TTX. Major advantages of this assay compared to indirect assays include increased speed of analysis, decreased use of biological reagents, and improved confidence in the detection of the toxin, along with the ability to characterize the antibody/toxin interaction. The analytical method introduced in this paper could be applied to other seafood toxins, as well as to a wide range of low molecular weight targets. JF - Analytical chemistry AU - Yakes, Betsy Jean AU - Kanyuck, Kelsey M AU - DeGrasse, Stacey L AD - U.S. Food and Drug Administration , Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, Maryland 20740, United States. Y1 - 2014/09/16/ PY - 2014 DA - 2014 Sep 16 SP - 9251 EP - 9255 VL - 86 IS - 18 KW - Antibodies KW - 0 KW - Tetrodotoxin KW - 4368-28-9 KW - Index Medicus KW - Antibodies -- immunology KW - Kinetics KW - Immunoassay KW - Tetrodotoxin -- analysis KW - Surface Plasmon Resonance KW - Food Contamination -- analysis KW - Seafood -- analysis KW - Biosensing Techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1562663516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=First+report+of+a+direct+surface+plasmon+resonance+immunosensor+for+a+small+molecule+seafood+toxin.&rft.au=Yakes%2C+Betsy+Jean%3BKanyuck%2C+Kelsey+M%3BDeGrasse%2C+Stacey+L&rft.aulast=Yakes&rft.aufirst=Betsy&rft.date=2014-09-16&rft.volume=86&rft.issue=18&rft.spage=9251&rft.isbn=&rft.btitle=&rft.title=Analytical+chemistry&rft.issn=1520-6882&rft_id=info:doi/10.1021%2Fac502271y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-08-28 N1 - Date created - 2014-09-16 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/ac502271y ER - TY - JOUR T1 - Mitochondrial topoisomerase I (top1mt) is a novel limiting factor of doxorubicin cardiotoxicity. AN - 1562663778; 24714774 AB - Doxorubicin is one of the most effective chemotherapeutic agents. However, up to 30% of the patients treated with doxorubicin suffer from congestive heart failure. The mechanism of doxorubicin cardiotoxicity is likely multifactorial and most importantly, the genetic factors predisposing to doxorubicin cardiotoxicity are unknown. On the basis of the fact that mtDNA lesions and mitochondrial dysfunctions have been found in human hearts exposed to doxorubicin and that mitochondrial topoisomerase 1 (Top1mt) specifically controls mtDNA homeostasis, we hypothesized that Top1mt knockout (KO) mice might exhibit hypersensitivity to doxorubicin. Wild-type (WT) and KO Top1mt mice were treated once a week with 4 mg/kg doxorubicin for 8 weeks. Heart tissues were analyzed one week after the last treatment. Genetic inactivation of Top1mt in mice accentuates mtDNA copy number loss and mtDNA damage in heart tissue following doxorubicin treatment. Top1mt KO mice also fail to maintain respiratory chain protein production and mitochondrial cristae ultrastructure organization. These mitochondrial defects result in decreased O2 consumption, increased reactive oxygen species production, and enhanced heart muscle damage in animals treated with doxorubicin. Accordingly, Top1mt KO mice die within 45 days after the last doxorubicin injection, whereas the WT mice survive. Our results provide evidence that Top1mt, which is conserved across vertebrates, is critical for cardiac tolerance to doxorubicin and adaptive response to doxorubicin cardiotoxicity. They also suggest the potential of Top1mt single-nucleotide polymorphisms testing to investigate patient susceptibility to doxorubicin-induced cardiotoxicity. ©2014 American Association for Cancer Research. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Khiati, Salim AU - Dalla Rosa, Ilaria AU - Sourbier, Carole AU - Ma, Xuefei AU - Rao, V Ashutosh AU - Neckers, Leonard M AU - Zhang, Hongliang AU - Pommier, Yves AD - Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology; ; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute; ; Laboratory of Molecular Cardiology, National Heart, Lung, and Blood Institute, NIH; and. ; Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, Maryland. ; Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology; pommier@nih.gov. Y1 - 2014/09/15/ PY - 2014 DA - 2014 Sep 15 SP - 4873 EP - 4881 VL - 20 IS - 18 SN - 1078-0432, 1078-0432 KW - Antibiotics, Antineoplastic KW - 0 KW - DNA, Mitochondrial KW - Doxorubicin KW - 80168379AG KW - DNA Topoisomerases, Type I KW - EC 5.99.1.2 KW - Index Medicus KW - Animals KW - DNA, Mitochondrial -- drug effects KW - Blotting, Western KW - DNA, Mitochondrial -- metabolism KW - Mice KW - Fluorescent Antibody Technique KW - Mice, Knockout KW - Mitochondria, Heart -- enzymology KW - Mitochondria, Heart -- drug effects KW - Doxorubicin -- toxicity KW - Cardiotoxicity -- enzymology KW - DNA Topoisomerases, Type I -- metabolism KW - Antibiotics, Antineoplastic -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1562663778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Mitochondrial+topoisomerase+I+%28top1mt%29+is+a+novel+limiting+factor+of+doxorubicin+cardiotoxicity.&rft.au=Khiati%2C+Salim%3BDalla+Rosa%2C+Ilaria%3BSourbier%2C+Carole%3BMa%2C+Xuefei%3BRao%2C+V+Ashutosh%3BNeckers%2C+Leonard+M%3BZhang%2C+Hongliang%3BPommier%2C+Yves&rft.aulast=Khiati&rft.aufirst=Salim&rft.date=2014-09-15&rft.volume=20&rft.issue=18&rft.spage=4873&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/10.1158%2F1078-0432.CCR-13-3373 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-07-31 N1 - Date created - 2014-09-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Cell Biol Toxicol. 2007 Jan;23(1):15-25 [17009097] Curr Cancer Drug Targets. 2006 Nov;6(7):579-602 [17100565] Mutat Res. 2007 Oct 1;623(1-2):83-97 [17681352] Biochemistry. 2008 Oct 28;47(43):11196-203 [18826252] Biochem Biophys Res Commun. 2009 Jan 16;378(3):450-5 [19032935] Biophys J. 2009 Feb 18;96(4):1388-98 [19217856] Nat Rev Cancer. 2009 May;9(5):338-50 [19377506] Antioxid Redox Signal. 2009 Nov;11(11):2685-700 [19558212] Methods. 2010 Aug;51(4):444-51 [20123023] Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19790-5 [21041670] Cold Spring Harb Protoc. 2011 May;2011(5):pdb.prot5623 [21536757] PLoS One. 2011;6(7):e21746 [21799747] Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2181-90 [21949114] Nat Rev Drug Discov. 2012 Jan;11(1):25-36 [22173432] J Clin Oncol. 2012 May 1;30(13):1415-21 [22124095] Tex Heart Inst J. 2012;39(3):424-7 [22719160] PLoS One. 2012;7(7):e41094 [22911747] Nat Med. 2012 Nov;18(11):1639-42 [23104132] J Biol Chem. 2013 Jan 11;288(2):915-26 [23152496] ACS Chem Biol. 2013 Jan 18;8(1):82-95 [23259582] Biochemistry (Mosc). 2012 Dec;77(13):1424-35 [23379519] PLoS One. 2013;8(8):e70575 [23940596] Life Sci. 2001 Jan 12;68(8):889-901 [11213359] Adv Drug Deliv Rev. 2001 Jul 2;49(1-2):87-105 [11377805] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10608-13 [11526219] Cardiovasc Toxicol. 2001;1(4):267-83 [12213966] Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12114-9 [12209014] Eur J Biochem. 2003 Oct;270(20):4173-86 [14519130] Circulation. 2003 Nov 11;108(19):2423-9 [14568902] N Engl J Med. 2004 Jul 8;351(2):120-1 [15247351] J Biol Chem. 2004 Sep 3;279(36):37575-87 [15220329] Biochim Biophys Acta. 1978 Jun 22;519(1):23-30 [566561] J Clin Invest. 1980 Jan;65(1):128-35 [7350193] Am J Pathol. 1980 Apr;99(1):13-42 [7361854] Biochem Biophys Res Commun. 1982 Jan 15;104(1):314-20 [6280691] Science. 1984 Oct 26;226(4673):466-8 [6093249] Am J Cardiol. 1985 Jul 1;56(1):157-61 [4014022] Biochemistry. 1987 Feb 24;26(4):1152-63 [3567161] Biochim Biophys Acta. 1987 Jul 22;892(3):320-30 [3036220] Biochem J. 1987 Jul 1;245(1):309-12 [3663157] Virchows Arch A Pathol Anat Histopathol. 1987;412(1):47-52 [3120403] Nucleic Acids Res. 1990 Nov 25;18(22):6611-9 [2174543] Biochim Biophys Acta. 1992 Aug 17;1132(1):43-8 [1380833] Semin Oncol. 1992 Dec;19(6):670-86 [1462166] Biochem Biophys Res Commun. 1993 Sep 15;195(2):945-51 [8373427] Semin Oncol. 1996 Aug;23(4 Suppl 8):23-34 [8783663] Biochim Biophys Acta. 1997 Aug 22;1321(2):101-6 [9332499] J Pathol. 2005 Dec;207(4):436-44 [16278810] Cardiovasc Toxicol. 2007;7(2):108-13 [17652814] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/1078-0432.CCR-13-3373 ER - TY - JOUR T1 - Discovering functional modules by topic modeling RNA-Seq based toxicogenomic data. AN - 1562431348; 25083553 AB - Toxicogenomics (TGx) endeavors to elucidate the underlying molecular mechanisms through exploring gene expression profiles in response to toxic substances. Recently, RNA-Seq is increasingly regarded as a more powerful alternative to microarrays in TGx studies. However, realizing RNA-Seq's full potential requires novel approaches to extracting information from the complex TGx data. Considering read counts as the number of times a word occurs in a document, gene expression profiles from RNA-Seq are analogous to a word by document matrix used in text mining. Topic modeling aiming at to discover the latent structures in text corpora would be helpful to explore RNA-Seq based TGx data. In this study, topic modeling was applied on a typical RNA-Seq based TGx data set to discover hidden functional modules. The RNA-Seq based gene expression profiles were transformed into "documents", on which latent Dirichlet allocation (LDA) was used to build a topic model. We found samples treated by the compounds with the same modes of actions (MoAs) could be clustered based on topic similarities. The topic most relevant to each cluster was identified as a "marker" topic, which was interpreted by gene enrichment analysis with MoAs then confirmed by compound and pathways associations mined from literature. To further validate the "marker" topics, we tested topic transferability from RNA-Seq to microarrays. The RNA-Seq based gene expression profile of a topic specifically associated with peroxisome proliferator-activated receptors (PPAR) signaling pathway was used to query samples with similar expression profiles in two different microarray data sets, yielding accuracy of about 85%. This proof-of-concept study demonstrates the applicability of topic modeling to discover functional modules in RNA-Seq data and suggests a valuable computational tool for leveraging information within TGx data in RNA-Seq era. JF - Chemical research in toxicology AU - Yu, Ke AU - Gong, Binsheng AU - Lee, Mikyung AU - Liu, Zhichao AU - Xu, Joshua AU - Perkins, Roger AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration , 3900 NCTR Road, Jefferson, Arkansas 72079, United States. Y1 - 2014/09/15/ PY - 2014 DA - 2014 Sep 15 SP - 1528 EP - 1536 VL - 27 IS - 9 KW - Peroxisome Proliferator-Activated Receptors KW - 0 KW - Receptors, Estrogen KW - RNA KW - 63231-63-0 KW - Index Medicus KW - Receptors, Estrogen -- genetics KW - Oligonucleotide Array Sequence Analysis KW - Sequence Analysis, RNA KW - Peroxisome Proliferator-Activated Receptors -- metabolism KW - Receptors, Estrogen -- metabolism KW - Transcriptome KW - Cluster Analysis KW - Signal Transduction KW - Peroxisome Proliferator-Activated Receptors -- genetics KW - Toxicogenetics KW - RNA -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1562431348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Discovering+functional+modules+by+topic+modeling+RNA-Seq+based+toxicogenomic+data.&rft.au=Yu%2C+Ke%3BGong%2C+Binsheng%3BLee%2C+Mikyung%3BLiu%2C+Zhichao%3BXu%2C+Joshua%3BPerkins%2C+Roger%3BTong%2C+Weida&rft.aulast=Yu&rft.aufirst=Ke&rft.date=2014-09-15&rft.volume=27&rft.issue=9&rft.spage=1528&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=1520-5010&rft_id=info:doi/10.1021%2Ftx500148n LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-19 N1 - Date created - 2014-09-15 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/tx500148n ER - TY - JOUR T1 - Real-time analysis of the effects of toxic, therapeutic and sub-therapeutic concentrations of digitoxin on lung cancer cells. AN - 1528336976; 24727605 AB - Digitoxin belongs to a naturally occurring class of cardiac glycosides (CG); digitoxin is clinically approved for heart failure and known for its anti-cancer effects against non-small lung cancer cells (NSCLC). However, concerns associated with its narrow therapeutic index and its concentration-dependent mechanism of action are rising. Thus, before digitoxin implementation in designing and developing safer and more effective CG-based anti-cancer therapies, its pharmacological and safety profiles need to be fully elucidated. In this research we used a combinatorial approach to evaluate the anti-cancer mechanisms of digitoxin in real-time. Our approach employed a non-invasive electric cell impedance sensing technique as a proxy to monitor NSCLC behavior post-exposure to toxic, therapeutic and sub-therapeutic concentrations of the drug. By developing structure-function combinatorial relations we showed that digitoxin targets cancer cells in a time and dose-dependant manner by activating pro-apoptotic and anti-proliferative signaling cascades that results in strengthening cellular adhesion and sequestration of key regulatory proliferation protein from the nucleus. Copyright © 2014 Elsevier B.V. All rights reserved. JF - Biosensors & bioelectronics AU - Eldawud, R AU - Stueckle, T A AU - Manivannan, S AU - Elbaz, H AU - Chen, M AU - Rojanasakul, Y AU - Dinu, C Z AD - Department of Chemical Engineering, West Virginia University, WV, United States. ; Health Effects Laboratory Division, National Institute for Occupational Safety and Health, WV, United States; Department of Basic Pharmaceutical Sciences, West Virginia University, WV, United States. ; Wayne State University School of Medicine, MI, United States. ; Department of Basic Pharmaceutical Sciences, West Virginia University, WV, United States. ; Department of Basic Pharmaceutical Sciences, West Virginia University, WV, United States; Mary Babb Randolph Cancer Center Allen Lung Program, West Virginia University, WV, United States. Electronic address: yrojan@hsc.wvu.edu. ; Department of Chemical Engineering, West Virginia University, WV, United States; Department of Basic Pharmaceutical Sciences, West Virginia University, WV, United States; Mary Babb Randolph Cancer Center Allen Lung Program, West Virginia University, WV, United States. Electronic address: cerasela-zoica.dinu@mail.wvu.edu. Y1 - 2014/09/15/ PY - 2014 DA - 2014 Sep 15 SP - 192 EP - 199 VL - 59 KW - Antineoplastic Agents KW - 0 KW - Cardiotonic Agents KW - Digitoxin KW - E90NZP2L9U KW - Index Medicus KW - Anti-cancer KW - Cell-based sensing KW - Cell adhesion KW - Humans KW - Signal Transduction -- drug effects KW - Apoptosis -- drug effects KW - Cell Line, Tumor KW - Cardiotonic Agents -- pharmacology KW - Lung -- pathology KW - Lung -- metabolism KW - Cell Adhesion -- drug effects KW - Biosensing Techniques -- methods KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Lung Neoplasms -- drug therapy KW - Digitoxin -- pharmacology KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Antineoplastic Agents -- pharmacology KW - Lung Neoplasms -- pathology KW - Lung Neoplasms -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1528336976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biosensors+%26+bioelectronics&rft.atitle=Real-time+analysis+of+the+effects+of+toxic%2C+therapeutic+and+sub-therapeutic+concentrations+of+digitoxin+on+lung+cancer+cells.&rft.au=Eldawud%2C+R%3BStueckle%2C+T+A%3BManivannan%2C+S%3BElbaz%2C+H%3BChen%2C+M%3BRojanasakul%2C+Y%3BDinu%2C+C+Z&rft.aulast=Eldawud&rft.aufirst=R&rft.date=2014-09-15&rft.volume=59&rft.issue=&rft.spage=192&rft.isbn=&rft.btitle=&rft.title=Biosensors+%26+bioelectronics&rft.issn=1873-4235&rft_id=info:doi/10.1016%2Fj.bios.2014.03.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-09 N1 - Date created - 2014-05-23 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 2012 Aug;1818(8):2030-47 [21871435] Int J Biochem Cell Biol. 2012 Nov;44(11):1813-24 [22750415] Mol Cell Biol. 2013 Mar;33(5):904-17 [23249949] Cancer Lett. 2013 Sep 1;337(2):177-83 [23684928] Differentiation. 2013 Oct;86(3):133-40 [23643492] Int J Biochem Cell Biol. 2013 Dec;45(12):2736-48 [24076216] Biochem Pharmacol. 2014 Mar 1;88(1):23-35 [24231508] Brain Res. 2000 Jan 17;853(1):115-24 [10627315] Exp Cell Res. 2000 Aug 25;259(1):158-66 [10942588] Am J Clin Pathol. 2001 Apr;115(4):600-4 [11293909] Oral Oncol. 2001 Jul;37(5):431-6 [11377231] Trends Cell Biol. 2003 Jun;13(6):310-8 [12791297] Biosens Bioelectron. 2004 Jan 15;19(6):583-94 [14683642] Mol Interv. 2003 May;3(3):157-68 [14993422] J Struct Biol. 2007 Nov;160(2):125-34 [17904382] Expert Opin Ther Targets. 2007 Aug;11(8):1043-53 [17665977] Res Vet Sci. 1973 Jul;15(1):81-7 [4204993] Exp Cell Res. 2007 Nov 1;313(18):3868-80 [17888903] Mol Interv. 2008 Feb;8(1):36-49 [18332483] Biochem Biophys Res Commun. 2008 Oct 31;375(4):608-13 [18755149] Atherosclerosis. 2009 Oct;206(2):390-6 [19446813] J Biol Chem. 2009 Oct 16;284(42):28845-55 [19703903] J Biomed Biotechnol. 2010;2010:402593 [20224657] Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11387-92 [20534449] Cancer Cell. 2010 Jul 13;18(1):63-73 [20609353] Biochim Biophys Acta. 2011 Jan;1815(1):13-25 [20801193] FASEB J. 2011 Feb;25(2):505-14 [20930113] Acta Pharmacol Sin. 2011 May;32(5):552-64 [21499288] Biosens Bioelectron. 2011 Aug 15;26(12):4720-7 [21684144] Mol Cancer Ther. 2011 Nov;10(11):2083-93 [21859838] Clin Cardiol. 1979 Apr;2(2):146-50 [262570] Proc Natl Acad Sci U S A. 1984 Jun;81(12):3761-4 [6587391] Biochem Biophys Res Commun. 1987 Feb 13;142(3):819-25 [3030302] Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7896-900 [1881923] Nature. 1993 Dec 9;366(6455):591-2 [8255299] J Clin Endocrinol Metab. 1995 Dec;80(12):3553-60 [8530598] J Cell Biol. 1997 Jul 14;138(1):181-92 [9214391] J Biol Chem. 2005 Feb 4;280(5):3747-56 [15548514] Toxicol Appl Pharmacol. 2005 Aug 7;206(2):102-12 [15967198] J Mol Biol. 2005 Sep 9;352(1):151-64 [16081103] J Nat Prod. 2005 Nov;68(11):1642-5 [16309315] Cell Biol Int. 2006 Feb;30(2):183-9 [16406622] Mol Cancer Ther. 2006 Feb;5(2):391-9 [16505114] Dev Cell. 2006 May;10(5):563-73 [16678773] Invest Ophthalmol Vis Sci. 2006 Jun;47(6):2408-16 [16723450] Leuk Res. 2006 Jul;30(7):895-8 [16387358] Neoplasia. 2006 May;8(5):402-12 [16790089] Anal Chem. 2006 Jul 15;78(14):5184-91 [16841946] Biochem Pharmacol. 2007 Mar 1;73(5):597-609 [16997283] Prog Histochem Cytochem. 2007;42(1):1-57 [17502225] Acta Pol Pharm. 2006 Mar-Apr;63(2):109-15 [17514873] Shock. 2011 Dec;36(6):548-52 [21937948] Dev Biol. 2012 Jan 1;361(1):68-78 [22020048] Cell Signal. 2012 Feb;24(2):393-401 [22024283] Toxicol Appl Pharmacol. 2012 Jan 1;258(1):51-60 [22037315] Biosens Bioelectron. 2012 Mar 15;33(1):196-203 [22261483] Fitoterapia. 2012 Apr;83(3):554-62 [22245088] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.bios.2014.03.030 ER - TY - JOUR T1 - Exposure to volatile organic compounds in healthcare settings AN - 1808665259; PQ0003441342 AB - ObjectivesTo identify and summarise volatile organic compound (VOC) exposure profiles of healthcare occupations.MethodsPersonal (n=143) and mobile area (n=207) evacuated canisters were collected and analysed by a gas chromatograph/mass spectrometer to assess exposures to 14 VOCs among 14 healthcare occupations in five hospitals. Participants were volunteers identified by their supervisors. Summary statistics were calculated by occupation. Principal component analysis (PCA) was used to reduce the 14 analyte inputs to five orthogonal factors and identify occupations that were associated with these factors. Linear regressions were used to assess the association between personal and mobile area samples.ResultsExposure profiles differed among occupations; ethanol had the highest geometric mean (GM) among nursing assistants ( similar to 4900 and similar to 1900 mu g/m3, personal and area), and 2-propanol had the highest GM among medical equipment preparers ( similar to 4600 and similar to 2000 mu g/m3, personal and area). The highest total personal VOC exposures were among nursing assistants ( similar to 9200 mu g/m3), licensed practical nurses ( similar to 8700 mu g/m3) and medical equipment preparers ( similar to 7900 mu g/m3). The influence of the PCA factors developed from personal exposure estimates varied by occupation, which enabled a comparative assessment of occupations. For example, factor 1, indicative of solvent use, was positively correlated with clinical laboratory and floor stripping/waxing occupations and tasks. Overall, a significant correlation was observed (r=0.88) between matched personal and mobile area samples, but varied considerably by analyte (r=0.23-0.64).ConclusionsHealthcare workers are exposed to a variety of chemicals that vary with the activities and products used during activities. These VOC profiles are useful for estimating exposures for occupational hazard ranking for industrial hygienists as well as epidemiological studies. JF - Occupational and Environmental Medicine AU - LeBouf, Ryan F AU - Virji, M Abbas AU - Saito, Rena AU - Henneberger, Paul K AU - Simcox, Nancy AU - Stefaniak, Aleksandr B AD - National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA Y1 - 2014/09/10/ PY - 2014 DA - 2014 Sep 10 SP - 642 EP - 650 PB - B M J Publishing Group, B.M.A. House London WC1H 9JR United Kingdom VL - 71 IS - 9 SN - 1351-0711, 1351-0711 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Solvents KW - Statistical analysis KW - Medical personnel KW - Health care KW - Medical equipment KW - Nursing KW - Principal components analysis KW - Occupational hazards KW - volatile organic compounds KW - Volatile organic compounds KW - Occupational exposure KW - Hospitals KW - Ethanol KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1808665259?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Exposure+to+volatile+organic+compounds+in+healthcare+settings&rft.au=LeBouf%2C+Ryan+F%3BVirji%2C+M+Abbas%3BSaito%2C+Rena%3BHenneberger%2C+Paul+K%3BSimcox%2C+Nancy%3BStefaniak%2C+Aleksandr+B&rft.aulast=LeBouf&rft.aufirst=Ryan&rft.date=2014-09-10&rft.volume=71&rft.issue=9&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/10.1136%2Foemed-2014-102080 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-07-01 N1 - Last updated - 2016-09-01 N1 - SubjectsTermNotLitGenreText - Medical equipment; Principal components analysis; Nursing; Occupational hazards; Statistical analysis; Solvents; volatile organic compounds; Occupational exposure; Ethanol; Hospitals; Chemicals; Health care; Medical personnel; Volatile organic compounds DO - http://dx.doi.org/10.1136/oemed-2014-102080 ER - TY - JOUR T1 - Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase. AN - 1561974409; 25209287 AB - Although dysregulated substance P (SP) has been implicated in the pathophysiology of Parkinson's disease (PD), how SP affects the survival of dopaminergic neurons remains unclear. Here, we found that mice lacking endogenous SP (TAC1(-/-)), but not those deficient in the SP receptor (neurokinin-1 receptor, NK1R), were more resistant to lipopolysaccharide (LPS)- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigral dopaminergic neurodegeneration than wild-type controls, suggesting a NK1R-independent toxic action of SP. In vitro dose-response studies revealed that exogenous SP enhanced LPS- and 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic neurodegeneration in a bimodal manner, peaking at submicromolar and subpicomolar concentrations, but was substantially less effective at intermediate concentrations. Mechanistically, the actions of submicromolar levels of SP were NK1R-dependent, whereas subpicomolar SP-elicited actions required microglial NADPH oxidase (NOX2), the key superoxide-producing enzyme, but not NK1R. Subpicomolar concentrations of SP activated NOX2 by binding to the catalytic subunit gp91(phox) and inducing membrane translocation of the cytosolic subunits p47(phox) and p67(phox). The importance of NOX2 was further corroborated by showing that inhibition or disruption of NOX2 blocked subpicomolar SP-exacerbated neurotoxicity. Together, our findings revealed a critical role of microglial NOX2 in mediating the neuroinflammatory and dopaminergic neurodegenerative effects of SP, which may provide new insights into the pathogenesis of PD. Copyright © 2014 the authors 0270-6474/14/3412490-14$15.00/0. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Wang, Qingshan AU - Chu, Chun-Hsien AU - Qian, Li AU - Chen, Shih-Heng AU - Wilson, Belinda AU - Oyarzabal, Esteban AU - Jiang, Lulu AU - Ali, Syed AU - Robinson, Bonnie AU - Kim, Hyoung-Chun AU - Hong, Jau-Shyong AD - Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, wangq4@niehs.nih.gov hong3@niehs.nih.gov. ; Neuropharmacology Section, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, Arkansas 72079, and. ; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea. Y1 - 2014/09/10/ PY - 2014 DA - 2014 Sep 10 SP - 12490 EP - 12503 VL - 34 IS - 37 KW - Lipopolysaccharides KW - 0 KW - Receptors, Neurokinin-1 KW - Substance P KW - 33507-63-0 KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Parkinson's disease KW - substance P KW - GPCR independence KW - neuroinflammation KW - NADPH oxidase KW - Animals KW - Enzyme Activation KW - Mice, Inbred C57BL KW - Mice KW - Male KW - Mice, Knockout KW - NADPH Oxidase -- metabolism KW - Parkinsonian Disorders -- chemically induced KW - Substance P -- metabolism KW - Receptors, Neurokinin-1 -- metabolism KW - Dopaminergic Neurons -- metabolism KW - Dopamine -- metabolism KW - Parkinsonian Disorders -- pathology KW - Parkinsonian Disorders -- metabolism KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1561974409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Substance+P+exacerbates+dopaminergic+neurodegeneration+through+neurokinin-1+receptor-independent+activation+of+microglial+NADPH+oxidase.&rft.au=Wang%2C+Qingshan%3BChu%2C+Chun-Hsien%3BQian%2C+Li%3BChen%2C+Shih-Heng%3BWilson%2C+Belinda%3BOyarzabal%2C+Esteban%3BJiang%2C+Lulu%3BAli%2C+Syed%3BRobinson%2C+Bonnie%3BKim%2C+Hyoung-Chun%3BHong%2C+Jau-Shyong&rft.aulast=Wang&rft.aufirst=Qingshan&rft.date=2014-09-10&rft.volume=34&rft.issue=37&rft.spage=12490&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/10.1523%2FJNEUROSCI.2238-14.2014 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-07 N1 - Date created - 2014-09-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: FASEB J. 2006 Feb;20(2):251-8 [16449797] Brain. 2012 Nov;135(Pt 11):3355-70 [23087045] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] Glia. 2007 Apr 1;55(5):453-62 [17203472] Int Rev Neurobiol. 2007;82:297-325 [17678968] Trends Neurosci. 2007 Nov;30(11):596-602 [17950926] Naunyn Schmiedebergs Arch Pharmacol. 2007 Oct;376(1-2):73-82 [17879086] Environ Health Perspect. 2008 May;116(5):593-8 [18470306] J Immunol. 2008 Jun 15;180(12):8241-9 [18523290] J Immunol. 2008 Jul 1;181(1):660-8 [18566433] Semin Immunopathol. 2008 Jul;30(3):339-63 [18509646] J Immunol. 2008 Nov 15;181(10):7194-204 [18981141] Antioxid Redox Signal. 2009 Oct;11(10):2481-504 [19309263] Antioxid Redox Signal. 2009 Sep;11(9):2151-66 [19243239] J Vis Exp. 2010;(35). pii: 1488. doi: 10.3791/1488 [20110936] Brain. 2010 Mar;133(Pt 3):808-21 [20123724] Neuropeptides. 2010 Oct;44(5):399-406 [20579732] J Neurosci. 2011 Jan 19;31(3):1081-92 [21248133] Environ Health Perspect. 2011 Jun;119(6):807-14 [21245015] J Immunol. 2011 Jun 15;186(12):7255-63 [21562162] Neurosci Lett. 2011 Sep 15;502(2):107-11 [21820035] Neuropharmacology. 2011 Dec;61(8):1389-98 [21907219] J Neuroinflammation. 2012;9:32 [22340895] Methods Mol Biol. 2013;1041:231-40 [23813383] J Neurosci. 2000 Aug 15;20(16):6309-16 [10934283] Occup Environ Med. 2003 May;60(5):378 [12709528] Brain. 2003 Jul;126(Pt 7):1683-90 [12805119] J Biol Chem. 2004 Jan 9;279(2):1415-21 [14578353] FASEB J. 2004 Mar;18(3):589-91 [14734632] J Immunol. 2004 May 1;172(9):5707-13 [15100316] Neurosci Lett. 2004 Sep 23;368(2):226-30 [15351454] Front Biosci. 2004 Sep 1;9:2153-65 [15353277] Brain Res. 1976 Nov 5;116(2):299-305 [974776] Res Publ Assoc Res Nerv Ment Dis. 1986;64:135-61 [2425403] Neurology. 1988 Aug;38(8):1285-91 [3399080] Exp Brain Res. 1990;82(2):293-303 [1704847] Mol Pharmacol. 1992 Jan;41(1):24-30 [1310144] Proc Natl Acad Sci U S A. 1992 May 1;89(9):3859-63 [1570304] Proc Natl Acad Sci U S A. 1996 May 14;93(10):4565-71 [8643444] Adv Exp Med Biol. 1996;387:97-106 [8794199] J Neural Transm Suppl. 1997;49:103-10 [9266419] J Biol Chem. 1997 Oct 24;272(43):27288-94 [9341176] FASEB J. 2005 Apr;19(6):550-7 [15791005] PLoS One. 2012;7(4):e34138 [22485158] J Neuroinflammation. 2012;9:124 [22695044] Brain. 2012 Sep;135(Pt 9):2750-65 [22915735] J Pharmacol Exp Ther. 2006 Nov;319(2):595-603 [16891616] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1523/JNEUROSCI.2238-14.2014 ER - TY - CPAPER T1 - Laboratory evaluations of a collapsible drill steel enclosure to reduce noise from roof bolting machines T2 - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AN - 1645187979; 6321759 JF - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AU - Azman, Amanda AU - Cargo, Hugo AU - Alcorn, Lynn Y1 - 2014/09/08/ PY - 2014 DA - 2014 Sep 08 KW - Enclosures KW - Drills KW - Noise levels KW - Noise reduction KW - Steel KW - Bolting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645187979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.atitle=Laboratory+evaluations+of+a+collapsible+drill+steel+enclosure+to+reduce+noise+from+roof+bolting+machines&rft.au=Azman%2C+Amanda%3BCargo%2C+Hugo%3BAlcorn%2C+Lynn&rft.aulast=Azman&rft.aufirst=Amanda&rft.date=2014-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc14/documents/NC14_Program_UPDATED9-4-2014.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-30 N1 - Last updated - 2015-01-14 ER - TY - CPAPER T1 - A noise control for air carbon arc cutting and gouging T2 - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AN - 1645185400; 6321762 JF - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AU - Lowe, M AU - Mechling, Jessie Y1 - 2014/09/08/ PY - 2014 DA - 2014 Sep 08 KW - Carbon KW - Cuttings KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645185400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.atitle=A+noise+control+for+air+carbon+arc+cutting+and+gouging&rft.au=Lowe%2C+M%3BMechling%2C+Jessie&rft.aulast=Lowe&rft.aufirst=M&rft.date=2014-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc14/documents/NC14_Program_UPDATED9-4-2014.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-30 N1 - Last updated - 2015-01-14 ER - TY - CPAPER T1 - Why buy quiet? T2 - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AN - 1645185302; 6321715 JF - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AU - Hayden, Charles AU - McCleery, Trudi Y1 - 2014/09/08/ PY - 2014 DA - 2014 Sep 08 KW - Acoustics KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645185302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.atitle=Why+buy+quiet%3F&rft.au=Hayden%2C+Charles%3BMcCleery%2C+Trudi&rft.aulast=Hayden&rft.aufirst=Charles&rft.date=2014-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc14/documents/NC14_Program_UPDATED9-4-2014.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-30 N1 - Last updated - 2015-01-14 ER - TY - CPAPER T1 - Underground evaluation of noise controls for LHD's and haul trucks used in underground metal / non-metal mines T2 - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AN - 1645184553; 6321763 JF - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AU - Peterson, Jeffrey AU - Yantek, David AU - Lowe, Jenae Y1 - 2014/09/08/ PY - 2014 DA - 2014 Sep 08 KW - Metals KW - Noise levels KW - Trucks KW - Mines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645184553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.atitle=Underground+evaluation+of+noise+controls+for+LHD%27s+and+haul+trucks+used+in+underground+metal+%2F+non-metal+mines&rft.au=Peterson%2C+Jeffrey%3BYantek%2C+David%3BLowe%2C+Jenae&rft.aulast=Peterson&rft.aufirst=Jeffrey&rft.date=2014-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc14/documents/NC14_Program_UPDATED9-4-2014.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-30 N1 - Last updated - 2015-01-14 ER - TY - CPAPER T1 - Development of a hearing loss estimation software T2 - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AN - 1645184433; 6321647 JF - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AU - Li, Mingfeng AU - Azman, Amanda AU - Thompson, James Y1 - 2014/09/08/ PY - 2014 DA - 2014 Sep 08 KW - Computer programs KW - Hearing loss UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645184433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.atitle=Development+of+a+hearing+loss+estimation+software&rft.au=Li%2C+Mingfeng%3BAzman%2C+Amanda%3BThompson%2C+James&rft.aulast=Li&rft.aufirst=Mingfeng&rft.date=2014-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc14/documents/NC14_Program_UPDATED9-4-2014.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-30 N1 - Last updated - 2015-01-14 ER - TY - CPAPER T1 - Study on active control of the radiated sound power from the cantilever plate T2 - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AN - 1645184260; 6321746 JF - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AU - Li, Mingfeng AU - Yang, Junyi AU - Camargo, Hugo Y1 - 2014/09/08/ PY - 2014 DA - 2014 Sep 08 KW - Sound UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645184260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.atitle=Study+on+active+control+of+the+radiated+sound+power+from+the+cantilever+plate&rft.au=Li%2C+Mingfeng%3BYang%2C+Junyi%3BCamargo%2C+Hugo&rft.aulast=Li&rft.aufirst=Mingfeng&rft.date=2014-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc14/documents/NC14_Program_UPDATED9-4-2014.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-30 N1 - Last updated - 2015-01-14 ER - TY - CPAPER T1 - Noise control concepts for a longwall cutting drum T2 - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AN - 1645184246; 6321761 JF - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AU - Yang, Junyi AU - Camargo, Hugo AU - Yantek, David Y1 - 2014/09/08/ PY - 2014 DA - 2014 Sep 08 KW - Cuttings KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645184246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.atitle=Noise+control+concepts+for+a+longwall+cutting+drum&rft.au=Yang%2C+Junyi%3BCamargo%2C+Hugo%3BYantek%2C+David&rft.aulast=Yang&rft.aufirst=Junyi&rft.date=2014-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc14/documents/NC14_Program_UPDATED9-4-2014.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-30 N1 - Last updated - 2015-01-14 ER - TY - CPAPER T1 - Correlation study on dynamic characteristics of the vane segment from a longwall cutting drum T2 - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AN - 1645183300; 6321757 JF - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AU - Li, Mingfeng AU - Yang, Junyi AU - Camargo, Hugo Y1 - 2014/09/08/ PY - 2014 DA - 2014 Sep 08 KW - Cuttings KW - Vanes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645183300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.atitle=Correlation+study+on+dynamic+characteristics+of+the+vane+segment+from+a+longwall+cutting+drum&rft.au=Li%2C+Mingfeng%3BYang%2C+Junyi%3BCamargo%2C+Hugo&rft.aulast=Li&rft.aufirst=Mingfeng&rft.date=2014-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc14/documents/NC14_Program_UPDATED9-4-2014.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-30 N1 - Last updated - 2015-01-14 ER - TY - CPAPER T1 - Publication Program of INCE/USA T2 - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AN - 1645183222; 6321628 JF - 2014 National Conference on Noise Control Engineering (Noise-Con 2014) AU - Thompson, James Y1 - 2014/09/08/ PY - 2014 DA - 2014 Sep 08 KW - USA KW - Acoustics KW - Noise levels UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645183222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.atitle=Publication+Program+of+INCE%2FUSA&rft.au=Thompson%2C+James&rft.aulast=Thompson&rft.aufirst=James&rft.date=2014-09-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+National+Conference+on+Noise+Control+Engineering+%28Noise-Con+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.inceusa.org/nc14/documents/NC14_Program_UPDATED9-4-2014.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-30 N1 - Last updated - 2015-01-14 ER - TY - JOUR T1 - Rat injury model of docetaxel extravasation. AN - 1826597058; 25054005 AB - Docetaxel is a novel type of chemotherapy drug that actively treats a number of malignant tumors. The aim of the present study was to explore the severity and natural course of tissue damage induced by docetaxel extravasation and to confirm the vesicant potential of docetaxel. Rats were selected for the establishment of the ulcer model. Different volumes and concentrations were explored to induce the skin ulcer and to confirm the optimum rational injection model. The natural course of tissue injury and pathological changes produced by docetaxel extravasation were observed by comparing to vinorelbine extravasation. A 0.4 ml volume and a 6 mg/ml concentration were the optimum rational injection model for the induction of the skin ulcer. The docetaxel extravasation induced local tissue necrosis, followed by granuloma formation and hyperpigmentation or scar formation. The severity of the injury depended on the concentration of the extravasation used in the rat model. The injury occurred on the first day following extravasation and lasted 4-6 weeks. The damage from docetaxel was weaker than vinorelbine in association with the depth and extension of necrosis. In conclusion, docetaxel extravasation can induce tissue necrosis. However, the severity of necrosis was weaker than that of vinorelbine. Docetaxel has superficial vesicant properties. JF - Biomedical reports AU - Zhu, Jing-Jing AU - Fu, Jian-Fei AU - Yang, Jiao AU - Hu, Bing AU - Zhang, Hui AU - Yu, Jian-Hua AD - Department of Rehabilitation, Jinhua Central Hospital (Jinhua Hospital of Zhejiang University), Jinhua, Zhejiang 321000, P.R. China. ; Department of Oncology, Jinhua Central Hospital (Jinhua Hospital of Zhejiang University), Jinhua, Zhejiang 321000, P.R. China. ; Cancer Institute, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China. ; Department of Pathology, Jinhua Central Hospital (Jinhua Hospital of Zhejiang University), Jinhua, Zhejiang 321000, P.R. China. ; Jinhua Food and Drug Administration, Jinhua, Zhejiang 321000, P.R. China. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 649 EP - 652 VL - 2 IS - 5 SN - 2049-9434, 2049-9434 KW - skin toxicity KW - pathology KW - docetaxel KW - extravasation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826597058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomedical+reports&rft.atitle=Rat+injury+model+of+docetaxel+extravasation.&rft.au=Zhu%2C+Jing-Jing%3BFu%2C+Jian-Fei%3BYang%2C+Jiao%3BHu%2C+Bing%3BZhang%2C+Hui%3BYu%2C+Jian-Hua&rft.aulast=Zhu&rft.aufirst=Jing-Jing&rft.date=2014-09-01&rft.volume=2&rft.issue=5&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Biomedical+reports&rft.issn=20499434&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date created - 2014-07-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Use of an active surveillance system by the FDA to observe patterns of quinine sulfate use and adverse hematologic outcomes in CMS Medicare data AN - 1727682263; 20662043 AB - Purpose In 2005, the Food and Drug Administration approved Qualaquin (quinine) for treatment of malaria and later ordered unapproved quinine formulations off the market. In 2009, labeling for Qualaquin added a warning for use for leg cramps, as serious hematologic reactions could occur. We examined quinine use trends among Medicare beneficiaries focusing on indications for use and associations with adverse hematologic outcomes. Methods Medicare beneficiaries, aged 65years and older, in 2006-2012, were included in incident quinine or comparator, diltiazem, cohorts if 183days prior to dispensing, they were enrolled in Medicare, had no dispensing of quinine, diltiazem, ticlodipine, clopidogrel, and sulfonamide drugs, and had no diagnoses of thrombocytopenia, immune thrombocytopenic purpura (ITP), thrombotic microangiopathy (TMA), or hemolytic-uremic syndrome (HUS). Diagnoses of malaria or leg cramps were observed during 183days prior to index dispensing. Outcomes of ITP, TMA, or HUS in inpatient or emergency room settings were then observed during drug use. Results Prevalent use of quinine decreased by 99%, from 419675 to 6036 users during 2006-2012. Of 88066 quinine users, 9 had diagnoses of malaria and 36218 had leg cramps. Incidence rates (per 1000 person-years) for ITP were quinine 1.67 and diltiazem 0.40 [incidence rate ratio 4.2 (95% confidence interval 2.5, 6.5)], for TMA were quinine 0.23 and diltiazem 0.03 [incidence rate ratio 6.9 (95% confidence interval 1.3, 24.0)], and for HUS were quinine 0 and diltiazem 0.01. Conclusions Use of quinine decreased substantially, although diagnoses of leg cramps persist. To our knowledge, this is the first demonstration of an association for quinine and ITP and TMA in claims data. Copyright copyright 2014 John Wiley & Sons, Ltd.. JF - Pharmacoepidemiology and Drug Safety AU - Houstoun, Monika AU - Reichman, Marsha E AU - Graham, David J AU - Nambiar, Sumathi AU - Shamsuddin, Hala AU - Jones, SChristopher AU - Cao, Kelly AU - Wernecke, Michael AU - Lam, Chelsea AU - Worrall, Chris M AU - MaCurdy, Thomas E AU - Kelman, Jeffrey A AD - Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 911 EP - 917 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 23 IS - 9 SN - 1053-8569, 1053-8569 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources KW - Symptoms KW - Human diseases KW - Emergencies KW - Malaria KW - Drugs KW - Q1 08604:Stock assessment and management KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1727682263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacoepidemiology+and+Drug+Safety&rft.atitle=Use+of+an+active+surveillance+system+by+the+FDA+to+observe+patterns+of+quinine+sulfate+use+and+adverse+hematologic+outcomes+in+CMS+Medicare+data&rft.au=Houstoun%2C+Monika%3BReichman%2C+Marsha+E%3BGraham%2C+David+J%3BNambiar%2C+Sumathi%3BShamsuddin%2C+Hala%3BJones%2C+SChristopher%3BCao%2C+Kelly%3BWernecke%2C+Michael%3BLam%2C+Chelsea%3BWorrall%2C+Chris+M%3BMaCurdy%2C+Thomas+E%3BKelman%2C+Jeffrey+A&rft.aulast=Houstoun&rft.aufirst=Monika&rft.date=2014-09-01&rft.volume=23&rft.issue=9&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Pharmacoepidemiology+and+Drug+Safety&rft.issn=10538569&rft_id=info:doi/10.1002%2Fpds.3644 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Symptoms; Human diseases; Emergencies; Malaria; Drugs DO - http://dx.doi.org/10.1002/pds.3644 ER - TY - JOUR T1 - Marital Status, Spousal Characteristics, and the Use of Preventive Care AN - 1680152350; 201516114 AB - In this article, we investigated the effects of marriage and spousal characteristics on the use of preventive care. We accounted for the endogeneity of marriage by combining propensity score estimation techniques with marriage transitions observed in longitudinal data. Results indicated that marriage increases the probability of dental check-ups and physical examinations for both sexes and mammograms and Pap smears for women. Next, we examined whether spousal characteristics affect the use of preventive care. Spousal education, income, health conditions, and preferences for risk and health care all affected use of preventive care in expected directions. Taken together, we conclude that marriage increases the use of preventive care; however, the net marital effect masks a heterogeneity that results from the characteristics of the spouse an individual marries. Adapted from the source document. JF - Journal of Family and Economic Issues AU - Miller, G Edward AU - Pylypchuk, Yuriy AD - Agency for Healthcare Research and Quality, Rockville, MD, USA emiller@ahrq.gov Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 323 EP - 338 PB - Springer, Dordrecht The Netherlands VL - 35 IS - 3 SN - 1058-0476, 1058-0476 KW - Marital Status KW - Risk KW - Probability KW - Marriage KW - Females KW - Health Education KW - Income KW - Health Care Services KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680152350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Family+and+Economic+Issues&rft.atitle=Marital+Status%2C+Spousal+Characteristics%2C+and+the+Use+of+Preventive+Care&rft.au=Miller%2C+G+Edward%3BPylypchuk%2C+Yuriy&rft.aulast=Miller&rft.aufirst=G&rft.date=2014-09-01&rft.volume=35&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+Family+and+Economic+Issues&rft.issn=10580476&rft_id=info:doi/10.1007%2Fs10834-013-9375-y LA - English DB - Sociological Abstracts N1 - Date revised - 2015-05-01 N1 - Number of references - 44 N1 - Last updated - 2016-09-28 N1 - CODEN - JFEIEE N1 - SubjectsTermNotLitGenreText - Marriage; Health Care Services; Health Education; Probability; Risk; Females; Marital Status; Income DO - http://dx.doi.org/10.1007/s10834-013-9375-y ER - TY - JOUR T1 - Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model AN - 1639980500; 21125001 AB - Parkinson's disease (PD) is a progressive motor disease of unknown etiology in the majority of cases. The clinical features of PD emerge due to selective degeneration of dopamine (DA) neurons in the substantia nigra pars compacta (SNc), which project to the caudate putamen (CPu) where they release DA. In the current in vivo mouse model study, we tested trehalose for its ability to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced damage to DA neurons. Trehalose is a naturally occurring disaccharide present in plants and animals and appears capable of protecting cells against various environmental stresses. The effect of trehalose is likely due to its action as a pharmacological chaperone which promotes protein stability. In the present study, there were four treatment groups: saline only (control); probenecid only; MPTP+probenecid; and trehalose+MPTP+probenecid. MPTP-induced losses in tyrosine hydroxylase and DA transporter immunoreactivity in the ventral midbrain SNc and CPu were significantly reduced by trehalose. Decreases in CPu dopamine levels produced by MPTP were also blocked by trehalose. Microglial activation and astrocytic hypertrophy induced by MPTP were greatly reduced by trehalose, indicating protection against neuroinflammation. These effects are commensurate with the observed trehalose sparing of motor deficits produced by MPTP in this mouse model. Two tight junctional proteins, ZO-1 and occludin, are downregulated following MPTP treatment and trehalose blocks this effect. Likewise, the glucose transporter-1 that is expressed in brain endothelial cells is also protected by trehalose from MPTP-induced down-regulation. This study is the first to demonstrate using fluoro-turoquoise FT gel perfusion techniques, the protection afforded by trehalose from MPTP-induced damage to microvessels and endothelial and suggests that trehalose therapy may have the potential to slow or ameliorate PD pathology. JF - Neurotoxicology AU - Sarkar, Sumit AU - Chigurupati, Srinivasulu AU - Raymick, James AU - Mann, Dushyant AU - Bowyer, John F AU - Schmitt, Tom AU - Beger, Richard D AU - Hanig, Joseph P AU - Schmued, Larry C AU - Paule, Merle G AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR 72079, United States Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 250 EP - 262 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 44 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Parkinson's disease KW - Endothelial cells KW - Trehalose KW - Tyrosine hydroxylase KW - FT-gel KW - Perfusion KW - MPTP KW - Plant protection KW - Animal models KW - Zonula occludens-1 protein KW - Putamen KW - Disaccharides KW - Neurodegenerative diseases KW - Mesencephalon KW - Dopamine KW - Movement disorders KW - Neurons KW - Immunoreactivity KW - Environmental stress KW - Chaperones KW - Tyrosine 3-monooxygenase KW - N3 11028:Neuropharmacology & toxicology KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639980500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Neuroprotective+effect+of+the+chemical+chaperone%2C+trehalose+in+a+chronic+MPTP-induced+Parkinson%27s+disease+mouse+model&rft.au=Sarkar%2C+Sumit%3BChigurupati%2C+Srinivasulu%3BRaymick%2C+James%3BMann%2C+Dushyant%3BBowyer%2C+John+F%3BSchmitt%2C+Tom%3BBeger%2C+Richard+D%3BHanig%2C+Joseph+P%3BSchmued%2C+Larry+C%3BPaule%2C+Merle+G&rft.aulast=Sarkar&rft.aufirst=Sumit&rft.date=2014-09-01&rft.volume=44&rft.issue=&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2014.07.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Perfusion; Plant protection; MPTP; Parkinson's disease; Animal models; Zonula occludens-1 protein; Trehalose; Putamen; Disaccharides; Endothelial cells; Mesencephalon; Neurodegenerative diseases; Movement disorders; Dopamine; Neurons; Immunoreactivity; Chaperones; Environmental stress; Tyrosine 3-monooxygenase DO - http://dx.doi.org/10.1016/j.neuro.2014.07.006 ER - TY - JOUR T1 - Comparison of a PCR serotyping assay, Check&Trace assay for Salmonella, and Luminex Salmonella serotyping assay for the characterization of Salmonella enterica identified from fresh and naturally contaminated cilantro AN - 1627976835; 20949723 AB - Salmonella enterica isolated from fresh cilantro samples collected through the USDA/AMS Microbiological Data Program (MDP) were used to compare a PCR serotyping assay against the Check&Trace assay and the Luminex (BioPlex) Salmonella serotyping assay. The study was conducted to evaluate the effectiveness of the three methods for serotyping Salmonella from both enrichment broth cultures and pure Salmonella cultures. In this investigation, Salmonella spp. serotyping was conducted using 24 h enrichment broth cultures and pure Salmonella cultures from cilantro samples, with the PCR serotyping assay. Conversely, the Check&Trace and Luminex for Salmonella assays required pure cultures for Salmonella serotyping. The cilantro samples contained S. enterica serovar Montevideo, Newport, Saintpaul, and Tennessee, identified by the PCR serotyping assay and Check&Trace for Salmonella, but the Luminex assay only identified two of the four serotypes of the cilantro samples. The anticipated impact from this study is that the PCR serotyping assay provides a time- and cost-effective means for screening, identifying and serotyping Salmonella using DNA extracted from 24 h enrichment cilantro samples. JF - Food Microbiology AU - Jean-Gilles Beaubrun, J AU - Ewing, L AU - Jarvis, K AU - Dudley, K AU - Grim, C AU - Gopinath, G AU - Flamer, M-L AU - Auguste, W AU - Jayaram, A AU - Elmore, J AU - Lamont, M AU - McGrath, T AU - Hanes, DE AD - U.S. Food and Drug Administration, Laurel, MD 20708, United States Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 181 EP - 187 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 42 SN - 0740-0020, 0740-0020 KW - Microbiology Abstracts B: Bacteriology; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Salmonella spp. KW - Molecular serotyping KW - Cilantro KW - Pure culture KW - USA, Tennessee KW - Uruguay, Montevideo KW - Serotypes KW - Data processing KW - Salmonella enterica KW - Economics KW - DNA KW - Assays KW - Serotyping KW - Polymerase chain reaction KW - A 01330:Food Microbiology KW - H 4000:Food and Drugs KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627976835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+Microbiology&rft.atitle=Comparison+of+a+PCR+serotyping+assay%2C+Check%26amp%3BTrace+assay+for+Salmonella%2C+and+Luminex+Salmonella+serotyping+assay+for+the+characterization+of+Salmonella+enterica+identified+from+fresh+and+naturally+contaminated+cilantro&rft.au=Jean-Gilles+Beaubrun%2C+J%3BEwing%2C+L%3BJarvis%2C+K%3BDudley%2C+K%3BGrim%2C+C%3BGopinath%2C+G%3BFlamer%2C+M-L%3BAuguste%2C+W%3BJayaram%2C+A%3BElmore%2C+J%3BLamont%2C+M%3BMcGrath%2C+T%3BHanes%2C+DE&rft.aulast=Jean-Gilles+Beaubrun&rft.aufirst=J&rft.date=2014-09-01&rft.volume=42&rft.issue=&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Food+Microbiology&rft.issn=07400020&rft_id=info:doi/10.1016%2Fj.fm.2014.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-04-29 N1 - SubjectsTermNotLitGenreText - Pure culture; Data processing; Serotypes; Polymerase chain reaction; Serotyping; Economics; DNA; Assays; Salmonella enterica; Uruguay, Montevideo; USA, Tennessee DO - http://dx.doi.org/10.1016/j.fm.2014.02.008 ER - TY - JOUR T1 - Fall Prevention Research and Practice: A Total Worker Safety Approach AN - 1627956581; 20906967 AB - Slips, trips, and falls (STF) represent a serious hazard to workers and occupants in many industries, homes, and communities. Often, the cause of a STF incident is multifactorial, encompassing human, environmental, and task risk factors. A STF-related disability can greatly diminish the occupational capability and quality of life of individuals in both the workplace and the home. Countering STF hazards and risks both on and off the job and on all aspects of control measures is a "total worker safety" matter, a challenging yet tangible undertaking. As the federal organization responsible for conducting research for the prevention of work-related injuries in the United States, the National Institute for Occupational Safety and Health (NIOSH) has been conducting research on STF controls for some decades. Many NIOSH research outcomes have been utilized for STF prevention in workplaces, with potential for prevention in homes as well. This paper summarizes the concept of total worker safety for STF control, NIOSH priority research goals, major activities, and accomplishments, and some emerging issues on STF. The strategic planning process for the NIOSH research goals and some identified research focuses are applicable to the development and implementation of global STF research goals. JF - Industrial Health AU - HSIAO, Hongwei AD - National Institute for Occupational Safety and Health, USA, hxh4@cdc.gov Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 381 EP - 392 PB - National Institute of Industrial Health. Japan., 21-1 Nagao 6-chome Kawasaki-shi 214-0023 Kanagawa-ken Japan VL - 52 IS - 5 SN - 0019-8366, 0019-8366 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Falls KW - Construction KW - Healthcare KW - Trade KW - Human characteristics KW - Public safety KW - Control measure KW - USA KW - Prevention KW - Injuries KW - Risk factors KW - Disabilities KW - Occupational safety KW - Safety KW - Priorities KW - Quality of life KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627956581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Industrial+Health&rft.atitle=Fall+Prevention+Research+and+Practice%3A+A+Total+Worker+Safety+Approach&rft.au=HSIAO%2C+Hongwei&rft.aulast=HSIAO&rft.aufirst=Hongwei&rft.date=2014-09-01&rft.volume=52&rft.issue=5&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Industrial+Health&rft.issn=00198366&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Prevention; Injuries; Disabilities; Risk factors; Safety; Occupational safety; Priorities; Quality of life; USA ER - TY - JOUR T1 - Influenza Vaccination Coverage Among School Employees: Assessing Knowledge, Attitudes, and Behaviors AN - 1627731110 AB - BACKGROUND Influenza can spread among students, teachers, and staff in school settings. Vaccination is the most effective method to prevent influenza. We determined 2012-2013 influenza vaccination coverage among school employees, assessed knowledge and attitudes regarding the vaccine, and determined factors associated with vaccine receipt. METHODS We surveyed 412 (49%) of 841 employees at 1 suburban Ohio school district in March 2013. The Web-based survey assessed personal and work characteristics, vaccine receipt, and knowledge and attitudes regarding the vaccine. RESULTS Overall, 238 (58%) respondents reported getting the 2012-2013 influenza vaccine. The most common reason for getting the vaccine was to protect oneself or oneʼs family (87%). Beliefs that the vaccine was not needed (32%) or that it was not effective (21%) were the most common reasons for not getting it. Factors independently associated with vaccine receipt were having positive attitudes toward the vaccine, feeling external pressure to get it, and feeling personal control over whether to get it. CONCLUSIONS Influenza vaccine coverage among school employees should be improved. Messages encouraging school employees to get the vaccine should address misconceptions about the vaccine. Employers should use methods to maximize employee vaccination as part of a comprehensive influenza prevention program. JF - The Journal of School Health AU - de Perio, Marie A AU - Wiegand, Douglas M AU - Brueck, Scott E AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-10, Cincinnati, OH 45226 ; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-9, Cincinnati, OH 45226 ; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-10, Cincinnati, OH 45226 Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 586 EP - 592 CY - Kent PB - Wiley Subscription Services, Inc. VL - 84 IS - 9 SN - 0022-4391 KW - Physical Fitness And Hygiene KW - Attitudes KW - Computer based KW - Coverage KW - Immunization KW - Influenza KW - Internet KW - Job characteristics KW - Misconceptions KW - Personal control KW - Positive thought KW - Preventive programmes KW - Teachers KW - Ohio UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627731110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+School+Health&rft.atitle=Influenza+Vaccination+Coverage+Among+School+Employees%3A+Assessing+Knowledge%2C+Attitudes%2C+and+Behaviors&rft.au=de+Perio%2C+Marie+A%3BWiegand%2C+Douglas+M%3BBrueck%2C+Scott+E&rft.aulast=de+Perio&rft.aufirst=Marie&rft.date=2014-09-01&rft.volume=84&rft.issue=9&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+School+Health&rft.issn=00224391&rft_id=info:doi/10.1111%2Fjosh.12184 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-10-14 N1 - Last updated - 2016-05-13 N1 - SubjectsTermNotLitGenreText - Ohio DO - http://dx.doi.org/10.1111/josh.12184 ER - TY - JOUR T1 - Coal bed reservoir simulation with geostatistical property realizations for simultaneous multi-well production history matching; a case study from Illinois Basin, Indiana, USA AN - 1623264141; 2014-089365 AB - Coal seam degasification is a means to recover energy from the methane gas retained in coal, and is also a supplementary measure to ventilation, which is proven to be one of the most effective ways to reduce methane emissions to a safe level in coal mines. Reservoir simulation is probably the most effective way to assess the coal seam as a "gas reservoir" and thereby its fluid-storage and flow-related properties. This objective is achieved by taking advantage of history matching of wellbore production. Reservoir simulation with multi-well history matching is a tedious process as important coal properties that affect wells' production characteristics are spatially variable across the seam. The common practice is to change various properties at the well blocks during the history matching process, and assume that they are uniform across the domain of interest. This process, however, often does not produce realistic and effective results for well or coal reservoir management. In this work, a multi-level approach to coal bed reservoir simulation is demonstrated for a group of coalbed methane wells in the Illinois Basin producing from the Seelyville Coal Member of the Linton Formation of the Carbondale Group (Pennsylvanian) in Indiana. This approach includes, in order, gas and water deliverability analyses of wells, geostatistical simulation and co-simulation, and coal bed reservoir simulation. It is shown that a reservoir model, which utilizes the geostatistical maps of important coal properties, is effective for simultaneous history matching of all wells, and eliminates the need for guessing and changing values of coal properties at and around individual well blocks. This methodology also provides realistic distributions of reservoir parameters and how they change during gas depletion, and thus aids in coal seam and coal gas management. Abstract Copyright (2014) Elsevier, B.V. JF - International Journal of Coal Geology AU - Karacan, C Ozgen AU - Drobniak, Agnieszka AU - Mastalerz, Maria Y1 - 2014/09/01/ PY - 2014 DA - 2014 Sep 01 SP - 71 EP - 89 PB - Elsevier, Amsterdam VL - 131 SN - 0166-5162, 0166-5162 KW - United States KW - Sullivan County Indiana KW - Pennsylvanian KW - natural gas KW - data processing KW - petroleum KW - coal seams KW - production KW - reservoir rocks KW - oil wells KW - sedimentary rocks KW - coal KW - Indiana KW - digital simulation KW - Carbondale Formation KW - Illinois Basin KW - numerical models KW - Paleozoic KW - statistical analysis KW - Carboniferous KW - Linton Formation KW - Middle Pennsylvanian KW - history KW - case studies KW - boreholes KW - coalbed methane KW - Seelyville coal member KW - 29A:Economic geology, geology of energy sources UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1623264141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Coal+Geology&rft.atitle=Coal+bed+reservoir+simulation+with+geostatistical+property+realizations+for+simultaneous+multi-well+production+history+matching%3B+a+case+study+from+Illinois+Basin%2C+Indiana%2C+USA&rft.au=Karacan%2C+C+Ozgen%3BDrobniak%2C+Agnieszka%3BMastalerz%2C+Maria&rft.aulast=Karacan&rft.aufirst=C&rft.date=2014-09-01&rft.volume=131&rft.issue=&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Coal+Geology&rft.issn=01665162&rft_id=info:doi/10.1016%2Fj.coal.2014.06.002 L2 - http://www.sciencedirect.com/science/journal/01665162 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2014, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2014-01-01 N1 - Number of references - 51 N1 - Document feature - illus. incl. 7 tables N1 - Last updated - 2014-11-13 N1 - SubjectsTermNotLitGenreText - boreholes; Carbondale Formation; Carboniferous; case studies; coal; coal seams; coalbed methane; data processing; digital simulation; history; Illinois Basin; Indiana; Linton Formation; Middle Pennsylvanian; natural gas; numerical models; oil wells; Paleozoic; Pennsylvanian; petroleum; production; reservoir rocks; sedimentary rocks; Seelyville coal member; statistical analysis; Sullivan County Indiana; United States DO - http://dx.doi.org/10.1016/j.coal.2014.06.002 ER - TY - JOUR T1 - Reproductive Health Risks Associated With Occupational Exposures to Antineoplastic Drugs in Health Care Settings: A Review of the Evidence AN - 1622603180; 20857609 AB - Objectives: Antineoplastic drugs are known reproductive and developmental toxicants. Our objective was to review the existing literature of reproductive health risks to workers who handle antineoplastic drugs. Methods: A structured literature review of 18 peer-reviewed, English language publications of occupational exposure and reproductive outcomes was performed. Results: Although effect sizes varied with study size and population, occupational exposure to antineoplastic drugs seems to raise the risk of both congenital malformations and miscarriage. Studies of infertility and time to pregnancy also suggested an increased risk for subfertility. Conclusions: Antineoplastic drugs are highly toxic in patients receiving treatment, and adverse reproductive effects have been well documented in these patients. Health care workers with long-term, low-level occupational exposure to these drugs also seem to have an increased risk of adverse reproductive outcomes. Additional precautions to prevent exposure should be considered. JF - Journal of Occupational and Environmental Medicine AU - Connor, Thomas H AU - Lawson, Christina C AU - Polovich, Martha AU - McDiarmid, Melissa A AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, MS C-23, 1090 Tusculum Avenue, Cincinnati, OH 45226, tconnor@cdc.gov PY - 2014 SP - 901 EP - 910 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 56 IS - 9 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Infertility KW - Toxicants KW - Abortion KW - Antineoplastic drugs KW - Medical personnel KW - Pregnancy KW - Literature reviews KW - Health care KW - Reviews KW - Congenital defects KW - Reproduction KW - Drugs KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622603180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Reproductive+Health+Risks+Associated+With+Occupational+Exposures+to+Antineoplastic+Drugs+in+Health+Care+Settings%3A+A+Review+of+the+Evidence&rft.au=Connor%2C+Thomas+H%3BLawson%2C+Christina+C%3BPolovich%2C+Martha%3BMcDiarmid%2C+Melissa+A&rft.aulast=Connor&rft.aufirst=Thomas&rft.date=2014-09-01&rft.volume=56&rft.issue=9&rft.spage=901&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000249 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Infertility; Toxicants; Abortion; Antineoplastic drugs; Medical personnel; Pregnancy; Health care; Literature reviews; Reviews; Congenital defects; Reproduction; Drugs; Occupational exposure DO - http://dx.doi.org/10.1097/JOM.0000000000000249 ER - TY - JOUR T1 - Prediction and validation of diffusion coefficients in a model drug delivery system using microsecond atomistic molecular dynamics simulation and vapour sorption analysis AN - 1620088585; 20728373 AB - Diffusion of small to medium sized molecules in polymeric medical device materials underlies a broad range of public health concerns related to unintended leaching from or uptake into implantable medical devices. However, obtaining accurate diffusion coefficients for such systems at physiological temperature represents a formidable challenge, both experimentally and computationally. While molecular dynamics simulation has been used to accurately predict the diffusion coefficients, D, of a handful of gases in various polymers, this success has not been extended to molecules larger than gases, e.g., condensable vapours, liquids, and drugs. We present atomistic molecular dynamics simulation predictions of diffusion in a model drug eluting system that represent a dramatic improvement in accuracy compared to previous simulation predictions for comparable systems. We find that, for simulations of insufficient duration, sub-diffusive dynamics can lead to dramatic over-prediction of D. We present useful metrics for monitoring the extent of sub-diffusive dynamics and explore how these metrics correlate to error in D. We also identify a relationship between diffusion and fast dynamics in our system, which may serve as a means to more rapidly predict diffusion in slowly diffusing systems. Our work provides important precedent and essential insights for utilizing atomistic molecular dynamics simulations to predict diffusion coefficients of small to medium sized molecules in condensed soft matter systems. JF - Soft Matter AU - Forrey, Christopher AU - Saylor, David M AU - Silverstein, Joshua S AU - Douglas, Jack F AU - Davis, Eric M AU - Elabd, Yossef A AD - Division of Chemistry and Materials Science; Center for Devices and Radiological Health; US Food and Drug Administration; USA; , christopher.forrey@fda.hhs.gov Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 7480 EP - 7494 PB - Royal Society of Chemistry VL - 10 IS - 38 SN - 1744-683X, 1744-683X KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Molecular modelling KW - Drug delivery KW - Sorption KW - Gases KW - Leaching KW - Molecular dynamics KW - Diffusion coefficient KW - Public health KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1620088585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Soft+Matter&rft.atitle=Prediction+and+validation+of+diffusion+coefficients+in+a+model+drug+delivery+system+using+microsecond+atomistic+molecular+dynamics+simulation+and+vapour+sorption+analysis&rft.au=Forrey%2C+Christopher%3BSaylor%2C+David+M%3BSilverstein%2C+Joshua+S%3BDouglas%2C+Jack+F%3BDavis%2C+Eric+M%3BElabd%2C+Yossef+A&rft.aulast=Forrey&rft.aufirst=Christopher&rft.date=2014-09-01&rft.volume=10&rft.issue=38&rft.spage=7480&rft.isbn=&rft.btitle=&rft.title=Soft+Matter&rft.issn=1744683X&rft_id=info:doi/10.1039%2Fc4sm01297f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Number of references - 99 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Temperature effects; Sorption; Drug delivery; Molecular modelling; Leaching; Gases; Molecular dynamics; Diffusion coefficient; Public health DO - http://dx.doi.org/10.1039/c4sm01297f ER - TY - JOUR T1 - Candidate Metrics for Evaluating the Impact of Prescriber Education on the Safe Use of Extended-Release/Long-Acting (ER/LA) Opioid Analgesics AN - 1618162594; 20749216 AB - Objective The objective of this study was to develop metrics to assess opioid prescribing behavior as part of the evaluation of the Extended-Release/Long-Acting (ER/LA) Opioid Analgesic Risk Evaluation and Mitigation Strategies (REMS). Design Candidate metrics were selected using published guidelines, examined using sensitivity analyses, and applied to cross-sectional rolling cohorts of Medicare patients prescribed with extended-release oxycodone (ERO) between July 2, 2006 and July 1, 2011. Potential metrics included prescribing opioid-tolerant-only ER/LA opioid analgesics to non-opioid-tolerant patients, prescribing early fills to patients, and ordering drug screens. Results Proposed definitions for opioid tolerance were seven continuous days of opioid usage of at least 30mg oxycodone equivalents, within the 7 days (primary) or 30 days (secondary) prior to first opioid-tolerant-only ERO prescription. Forty-four percent of opioid-tolerant-only ERO episodes met the primary opioid tolerance definition; 56% met the secondary definition. Fills were deemed "early" if a prescription was filled before 70% (primary) or 50% (secondary) of the prior prescription's days' supply was to be consumed. Five percent (primary) and 2% (secondary) of episodes had more than or equal to two early fills during treatment. At least one drug screen was billed in 14% of episodes. Stratified analyses indicated that older patients were less likely to be opioid tolerant at the time of the first opioid-tolerant-only ERO prescription. Conclusions Investigators propose three metrics to monitor changes in prescribing behaviors for opioid analgesics that might be used to evaluate the ER/LA Opioid Analgesics REMS. Low frequencies of patients, particularly those >85 years, were likely to be opioid tolerant prior to receiving prescriptions for opioid-tolerant-only ERO. JF - Pain Medicine AU - Willy, Mary E AU - Graham, David J AU - Racoosin, Judith A AU - Gill, Rajdeep AU - Kropp, Garner F AU - Young, Jessica AU - Yang, Jeff AU - Choi, Joyce AU - MaCurdy, Thomas E AU - Worrall, Chris AU - Kelman, Jeffrey A AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1558 EP - 1568 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 15 IS - 9 SN - 1526-2375, 1526-2375 KW - Risk Abstracts KW - Risk assessment KW - Mitigation KW - Education KW - Sensitivity analysis KW - Guidelines KW - Risk taking KW - Pain KW - Drugs KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1618162594?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pain+Medicine&rft.atitle=Candidate+Metrics+for+Evaluating+the+Impact+of+Prescriber+Education+on+the+Safe+Use+of+Extended-Release%2FLong-Acting+%28ER%2FLA%29+Opioid+Analgesics&rft.au=Willy%2C+Mary+E%3BGraham%2C+David+J%3BRacoosin%2C+Judith+A%3BGill%2C+Rajdeep%3BKropp%2C+Garner+F%3BYoung%2C+Jessica%3BYang%2C+Jeff%3BChoi%2C+Joyce%3BMaCurdy%2C+Thomas+E%3BWorrall%2C+Chris%3BKelman%2C+Jeffrey+A&rft.aulast=Willy&rft.aufirst=Mary&rft.date=2014-09-01&rft.volume=15&rft.issue=9&rft.spage=1558&rft.isbn=&rft.btitle=&rft.title=Pain+Medicine&rft.issn=15262375&rft_id=info:doi/10.1111%2Fpme.12459 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-01 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Education; Mitigation; Sensitivity analysis; Guidelines; Risk taking; Pain; Drugs DO - http://dx.doi.org/10.1111/pme.12459 ER - TY - JOUR T1 - IL-10 and NOS2 Modulate Antigen-Specific Reactivity and Nerve Infiltration by T Cells in Experimental Leprosy AN - 1618154796; 20748168 AB - Despite effective antimicrobial therapy, 30-50% of leprosy patients develop immunological complications called leprosy reactions before, during or even years after being cured. Leprosy reactions are a major risk for neuritis that leads to peripheral nerve damage, disfigurement and disability. Unfortunately, why and how leprosy reactions occur is not well understood. Based on the latest human genetic leprosy susceptibility research and mouse infection models, we generated a double knockout mouse strain (10NOS2-/-) which has deficiencies in two key immune factors, interleukin-10 (IL-10) and inducible nitric oxide synthase (NOS2). We investigated the dynamics of the immune response to Mycobacterium leprae infection and chronicled the types of immune cells recruited to the site of infection. 10NOS2-/- mice developed a substantial induration in response to infection, as well as an increased interferon-gamma response to components of the leprosy bacillus. Interestingly, these animals also exhibited CD4+ T cell infiltration into the nerves, a phenomenon which has not been previously reported in leprosy mouse models. This new model provides insight into potential mechanisms whereby immune modulators may regulate leprosy reactions and neuritis and could aid the development of tests for monitoring and treatment of leprosy patients. JF - PLoS Neglected Tropical Diseases AU - Hagge, Deanna A AU - Scollard, David M AU - Ray, Nashone A AU - Marks, Vilma T AU - Deming, Angelina T AU - Spencer, John S AU - Adams, Linda B AD - Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, National Hansen's Disease Programs, Baton Rouge, Louisiana, United States of America PY - 2014 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 8 IS - 9 SN - 1935-2727, 1935-2727 KW - Microbiology Abstracts B: Bacteriology KW - gamma -Interferon KW - Mycobacterium leprae KW - Animal models KW - Infection KW - Immunomodulation KW - Interleukin 10 KW - Leprosy KW - Neuritis KW - Antimicrobial agents KW - Nitric-oxide synthase KW - CD4 antigen KW - Lymphocytes T KW - Bacillus KW - Peripheral nerves KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1618154796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=IL-10+and+NOS2+Modulate+Antigen-Specific+Reactivity+and+Nerve+Infiltration+by+T+Cells+in+Experimental+Leprosy&rft.au=Hagge%2C+Deanna+A%3BScollard%2C+David+M%3BRay%2C+Nashone+A%3BMarks%2C+Vilma+T%3BDeming%2C+Angelina+T%3BSpencer%2C+John+S%3BAdams%2C+Linda+B&rft.aulast=Hagge&rft.aufirst=Deanna&rft.date=2014-09-01&rft.volume=8&rft.issue=9&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0003149 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-10-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Nitric-oxide synthase; gamma -Interferon; CD4 antigen; Lymphocytes T; Animal models; Infection; Immunomodulation; Peripheral nerves; Interleukin 10; Antimicrobial agents; Neuritis; Leprosy; Mycobacterium leprae; Bacillus DO - http://dx.doi.org/10.1371/journal.pntd.0003149 ER - TY - JOUR T1 - Glycosylated and Nonglycosylated Complement Control Protein of the Lister Strain of Vaccinia Virus AN - 1566843306; 20698253 AB - The vaccinia virus complement control protein (VCP) is a secreted viral protein that binds the C3b and C4b complement components and inhibits the classic and alternative complement pathways. Previously, we reported that an attenuated smallpox vaccine, LC16m8, which was derived from the Lister strain of vaccinia virus (VV-Lister), expressed a glycosylated form of VCP, whereas published sequence data at that time indicated that the VV-Lister VCP has no motif for N-linked glycosylation. We were interested in determining whether the glycosylation of VCP impairs its biological activity, possibly contributing to the attenuation of LC16m8, and the likely origin of the glycosylated VCP. Expression analysis indicated that VV-Lister contains substrains expressing glycosylated VCP and substrains expressing nonglycosylated VCP. Other strains of smallpox vaccine, as well as laboratory strains of vaccinia virus, all expressed nonglycosylated VCP. Individual Lister virus clones expressing either the glycosylated VCP or the nonglycosylated species were isolated, and partially purified VCP from the isolates were found to be functional equivalents in binding human C3b and C4b complement proteins and inhibiting hemolysis and in immunogenicity. Recombinant vaccinia viruses expressing FLAG-tagged glycosylated VCP (FLAG-VCPg) and nonglycosylated VCP (FLAG-VCP) were constructed based on the Western Reserve strain. Purified FLAG-VCP and FLAG-VCPg bind human C3b and C4b and blocked complement-mediated hemolysis. Our data suggest that glycosylation did not affect the biological activity of VCP and thus may not have contributed to the attenuation of LC16m8. In addition, the LC16m8 virus likely originated from a substrain of VV-Lister that expresses glycosylated VCP. JF - Clinical and Vaccine Immunology AU - Meseda, Clement A AU - Kuhn, Jordan AU - Atukorale, Vajini AU - Campbell, Joseph AU - Weir, Jerry P Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1330 EP - 1338 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 21 IS - 9 SN - 1556-6811, 1556-6811 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Smallpox KW - complement control proteins KW - Vaccinia virus KW - Data processing KW - Complement component C3b KW - Immunogenicity KW - Vaccinia KW - Complement KW - Hemolysis KW - Glycosylation KW - Vaccines KW - V 22350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566843306?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Glycosylated+and+Nonglycosylated+Complement+Control+Protein+of+the+Lister+Strain+of+Vaccinia+Virus&rft.au=Meseda%2C+Clement+A%3BKuhn%2C+Jordan%3BAtukorale%2C+Vajini%3BCampbell%2C+Joseph%3BWeir%2C+Jerry+P&rft.aulast=Meseda&rft.aufirst=Clement&rft.date=2014-09-01&rft.volume=21&rft.issue=9&rft.spage=1330&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/10.1128%2FCVI.00347-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 31 N1 - Last updated - 2014-12-24 N1 - SubjectsTermNotLitGenreText - complement control proteins; Smallpox; Data processing; Complement component C3b; Vaccinia; Immunogenicity; Complement; Hemolysis; Vaccines; Glycosylation; Vaccinia virus DO - http://dx.doi.org/10.1128/CVI.00347-14 ER - TY - JOUR T1 - T-bet modulates the antibody response and immune protection during murine malaria AN - 1566834136; 20720290 AB - CD4 super(+) T-cell subtypes govern the synthesis of different Ab isotypes and other immune functions. The influence of CD4 super(+) T-cell differentiation programs on isotype switching and other aspects of host immunological networks during malaria infection are currently poorly understood. Here, we used Tbx21 super(-/-) mice deficient for T-bet, a regulator of Th1 CD4 super(+) T-cell differentiation, to examine the effect of Th1 CD4 super(+) T cells on the immune protection to nonlethal murine malaria Plasmodium yoelii 17XNL. We found that Tbx21 super(-/-) mice exhibited significantly lower parasite burden that correlated with elevated levels of IgG1, indicating that T-bet-dependent Ab isotype switching may be responsible for lower parasite burden. Absence of T-bet was also associated with a transient but significant loss of T cells during the infection, suggesting that T-bet may suppress malaria-induced apoptosis or induce proliferation of T cells. However, Tbx21 super(-/-) mice produced greater numbers of Foxp3 super(+)CD25 super(+) regulatory CD4 super(+) T cells, which may contribute to the early contraction of T cells. Lastly, Tbx21 super(-/-) mice exhibited unimpaired production of IFN- gamma by a diverse repertoire of immune cell subsets and a selective expansion of IFN- gamma -producing T cells. These observations may have implications in malaria vaccine design. JF - European Journal of Immunology AU - Oakley, Miranda S AU - Sahu, Bikash R AU - Lotspeich-Cole, Leda AU - Majam, Victoria AU - Thao Pham, Phuong AU - Sengupta Banerjee, Aditi AU - Kozakai, Yukiko AU - Morris, Sheldon L AU - Kumar, Sanjai AD - Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, MD, USA. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 2680 EP - 2691 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 44 IS - 9 SN - 0014-2980, 0014-2980 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - gamma -Interferon KW - Parasites KW - Human diseases KW - Apoptosis KW - Helper cells KW - Disease control KW - Malaria KW - Hosts KW - Infection KW - Public health KW - Differentiation KW - CD4 antigen KW - Lymphocytes T KW - Plasmodium yoelii KW - Immunology KW - Antibody response KW - Antibodies KW - Immunoglobulin G KW - Immune response KW - Vaccines KW - Cell proliferation KW - K 03350:Immunology KW - F 06905:Vaccines KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566834136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Immunology&rft.atitle=T-bet+modulates+the+antibody+response+and+immune+protection+during+murine+malaria&rft.au=Oakley%2C+Miranda+S%3BSahu%2C+Bikash+R%3BLotspeich-Cole%2C+Leda%3BMajam%2C+Victoria%3BThao+Pham%2C+Phuong%3BSengupta+Banerjee%2C+Aditi%3BKozakai%2C+Yukiko%3BMorris%2C+Sheldon+L%3BKumar%2C+Sanjai&rft.aulast=Oakley&rft.aufirst=Miranda&rft.date=2014-09-01&rft.volume=44&rft.issue=9&rft.spage=2680&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Immunology&rft.issn=00142980&rft_id=info:doi/10.1002%2Feji.201344437 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Parasites; Antibodies; Human diseases; Immunology; Disease control; Malaria; Hosts; Vaccines; Public health; gamma -Interferon; Apoptosis; Helper cells; Antibody response; Infection; Differentiation; CD4 antigen; Lymphocytes T; Immunoglobulin G; Immune response; Cell proliferation; Plasmodium yoelii DO - http://dx.doi.org/10.1002/eji.201344437 ER - TY - JOUR T1 - Semiparametric methods for survival analysis of case-control data subject to dependent censoring AN - 1566375194; 4602504 AB - Case-control sampling can be an efficient and cost-saving study design, wherein subjects are selected into the study based on the outcome of interest. It was established long ago that proportional hazards regression can be applied to case‐ ;control data. However, each of the various estimation techniques available assumes that failure times are independently censored. Since independent censoring is often violated in observational studies, we propose methods for Cox regression analysis of survival data obtained through case-control sampling, but subject to dependent censoring. The proposed methods are based on weighted estimating equations, with separate inverse weights used to account for the case-control sampling and to correct for dependent censoring. The proposed estimators are shown to be consistent and asymptotically normal, and consistent estimators of the asymptotic covariance matrices are derived. Finite-sample properties of the proposed estimators are examined through simulation studies. The methods are illustrated through an analysis of pre‐ ;transplant mortality among end-stage liver disease patients obtained from a national organ failure registry. The Canadian Journal of Statistics 42: 365-383; 2014 © 2014 Statistical Society of Canada // ABSTRACT IN : L'échantillonnage cas-témoins peut constituer un plan d'expérience efficace et économique dans le cadre duquel les sujets sont choisis pour l'étude en fonction du phénomène étudié. Il est établi depuis longtemps que le modèle de régression à risques proportionnels peut s'appliquer à des données cas‐ ;témoins. Cependant, toutes les techniques d'estimation existantes supposent que les temps de défaillance sont censurés de façon indépendante. Étant donné ; que l'indépendance de la censure est souvent bafouée dans le cadre d'études observationnelles, les auteurs proposent des méthodes pour la régression de Cox de données de survie sujettes à la censure dépendante obtenues par un échantillonnage cas-témoins. Les méthodes proposées se fondent sur des équations d'estimation pondérées dont les poids séparés et inverses permettent de tenir compte de l'é ;chantillonnage cas-témoins et de corriger le biais lié à la censure dépendante. Les auteurs montrent que les estimateurs proposés sont convergents et asymptotiquement normaux. Ils obtiennent également des estimateurs convergents pour les matrices de covariance asymptotique. Ils examinent les propriétés de ces estimateurs sur des échantillons de taille finie par voie de simulation et illustrent les méthodes au moyen d'une analyse de données sur le taux de mortalité pré ;transplantation chez les patients atteints d'une maladie hé ;patique en phase terminale provenant d'un registre national d'organes défaillants. La revue canadienne de statistique 42: 365-383; 2014 © 2014 Société statistique du Canada JF - Canadian journal of statistics AU - Kalbfleisch, John D AU - Shu, Xu AU - Schaubel, Douglas E AU - Zhang, Hui AD - University of Michigan ; US Food and Drug Administration Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 365 EP - 383 VL - 42 IS - 3 SN - 0319-5724, 0319-5724 KW - Economics KW - Mortality KW - Canada KW - Regression analysis KW - Simulation KW - Estimation KW - Sampling KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566375194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+statistics&rft.atitle=Semiparametric+methods+for+survival+analysis+of+case-control+data+subject+to+dependent+censoring&rft.au=Kalbfleisch%2C+John+D%3BShu%2C+Xu%3BSchaubel%2C+Douglas+E%3BZhang%2C+Hui&rft.aulast=Kalbfleisch&rft.aufirst=John&rft.date=2014-09-01&rft.volume=42&rft.issue=3&rft.spage=365&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+statistics&rft.issn=03195724&rft_id=info:doi/10.1002%2Fcjs.11218 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-09-29 N1 - Last updated - 2014-09-30 N1 - SubjectsTermNotLitGenreText - 10739 12228 10919; 4403 7854; 8291 3409 6306; 7994; 11255 12228 10919; 11670; 75 293 14 DO - http://dx.doi.org/10.1002/cjs.11218 ER - TY - RPRT T1 - FOREWORD AN - 1565800416 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1565800416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-09-01&rft.volume=&rft.issue=587&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2014 N1 - Last updated - 2015-03-21 ER - TY - RPRT T1 - Table of contents AN - 1565800370 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1565800370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-09-01&rft.volume=&rft.issue=587&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2014 N1 - Last updated - 2015-03-21 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY STUDIES OF TETRABROMOBISPHENOL A (CAS NO. 79-94-7) IN F344/NTac RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF TETRABROMOBISPHENOL A IN WISTAR HAN [Crl: WI(Han)] RATS AND B6C3F1/N MICE (GAVAGE STUDIES) AN - 1565800305 AB - Tetrabromobisphenol A is used as a flame retardant in circuit boards and in enclosures of electronics. We studied the effects of tetrabromombisphenol A on male and female rats and mice to identify potential toxic or cancer-related hazards. We deposited solutions containing tetrabromobisphenol A in com oil through a tube directly into the stomach to groups of 50 male and female rats and mice 5 days per week for 2 years. Exposed animals received either 250, 500, or 1,000 milligrams (mg) of tetrabromobisphenol A per kilogram (kg) of body weight. Control animals received com oil with no chemical added by the same method. At the end of the study, tissues from more than 40 sites were examined for every animal. Three male rats receiving 1,000 mg/kg of tetrabromobisphenol A had uncommon adenomas of the testis. In female rats there were significant increases in the incidences of malignant tumors of the uterus. In male mice there was a significant increase in the incidence of a rare type of liver tumor (hepatoblastoma) and also occurrences of hemagiosarcomas and three rare tumors of the large intestine. We conclude that tetrabromobisphenol A caused cancers of the uterus in female rats and of the liver in male mice. Occurrences of testicular tumors in male rats and hemangiosarcomas and tumors of the large intestine in male mice may also have been related to exposure to tetrabromobisphenol A. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1 EP - 15,17-65,67-91,93-125,127-151,153-155,157-167,169-195 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Studies KW - Toxicology KW - Hazardous substances KW - Carcinogens KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1565800305?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+STUDIES+OF+TETRABROMOBISPHENOL+A+%28CAS+NO.+79-94-7%29+IN+F344%2FNTac+RATS+AND+B6C3F1%2FN+MICE+AND+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+TETRABROMOBISPHENOL+A+IN+WISTAR+HAN+%5BCrl%3A+WI%28Han%29%5D+RATS+AND+B6C3F1%2FN+MICE+%28GAVAGE+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-09-01&rft.volume=&rft.issue=587&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Sep 2014 N1 - Document feature - Illustrations; Tables; References; Graphs N1 - Last updated - 2015-03-21 ER - TY - JOUR T1 - Do hearing protectors protect hearing? AN - 1560123656; 20594893 AB - Background We examined the association between self-reported hearing protection use at work and incidence of hearing shifts over a 5-year period. Methods Audiometric data from 19,911 workers were analyzed. Two hearing shift measures-OSHA standard threshold shift (OSTS) and high-frequency threshold shift (HFTS)-were used to identify incident shifts in hearing between workers' 2005 and 2009 audiograms. Adjusted odds ratios were generated using multivariable logistic regression with multi-level modeling. Results The odds ratio for hearing shift for workers who reported never versus always wearing hearing protection was nonsignificant for OSTS (OR 1.23, 95% CI 0.92-1.64) and marginally significant for HFTS (OR 1.26, 95% CI 1.00-1.59). A significant linear trend towards increased risk of HFTS with decreased use of hearing protection was observed (P=0.02). Conclusion The study raises concern about the effectiveness of hearing protection as a substitute for noise control to prevent noise-induced hearing loss in the workplace. Am. J. Ind. Med. 57:1001-1010, 2014. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Groenewold, Matthew R AU - Masterson, Elizabeth A AU - Themann, Christa L AU - Davis, Rickie R AD - Surveillance Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Cincinnati, Ohio. Y1 - 2014/09// PY - 2014 DA - Sep 2014 SP - 1001 EP - 1010 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 9 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - USA KW - Noise levels KW - Hearing loss KW - H 1000:Occupational Safety and Health KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560123656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Do+hearing+protectors+protect+hearing%3F&rft.au=Groenewold%2C+Matthew+R%3BMasterson%2C+Elizabeth+A%3BThemann%2C+Christa+L%3BDavis%2C+Rickie+R&rft.aulast=Groenewold&rft.aufirst=Matthew&rft.date=2014-09-01&rft.volume=57&rft.issue=9&rft.spage=1001&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22323 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - Noise levels; Hearing loss; USA DO - http://dx.doi.org/10.1002/ajim.22323 ER - TY - JOUR T1 - Developing a systematic approach to safer medication use during pregnancy: summary of a Centers for Disease Control and Prevention--convened meeting. AN - 1558526278; 24881821 AB - To address information gaps that limit informed clinical decisions on medication use in pregnancy, the Centers for Disease Control and Prevention (CDC) solicited expert input on a draft prototype outlining a systematic approach to evaluating the quality and strength of existing evidence for associated risks. The draft prototype outlined a process for the systematic review of available evidence and deliberations by a panel of experts to inform clinical decision making for managing health conditions in pregnancy. At an expert meeting convened by the CDC in January 2013, participants divided into working groups discussed decision points within the prototype. This report summarizes their discussions of best practices for formulating an expert review process, developing evidence summaries and treatment guidance, and disseminating information. There is clear recognition of current knowledge gaps and a strong collaboration of federal partners, academic experts, and professional organizations willing to work together toward safer medication use during pregnancy. Published by Elsevier Inc. JF - American journal of obstetrics and gynecology AU - Broussard, Cheryl S AU - Frey, Meghan T AU - Hernandez-Diaz, Sonia AU - Greene, Michael F AU - Chambers, Christina D AU - Sahin, Leyla AU - Collins Sharp, Beth A AU - Honein, Margaret A AD - National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA. Electronic address: cbroussard@cdc.gov. ; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA; Oak Ridge Institute for Science and Education, Oak Ridge, TN. ; Harvard School of Public Health, Boston, MA. ; Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School and Massachusetts General Hospital, Boston, MA. ; Departments of Pediatrics and Family and Preventive Medicine, University of California, San Diego, La Jolla, CA. ; Pediatric and Maternal Health Staff, Maternal Health Team, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD. ; Agency for Healthcare Research and Quality, Rockville, MD. ; National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 208 EP - 214.e1 VL - 211 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - teratogens KW - medications KW - Centers for Disease Control and Prevention KW - pregnancy KW - expert review KW - United States KW - Animals KW - Centers for Disease Control and Prevention (U.S.) KW - Humans KW - Safety KW - Practice Guidelines as Topic KW - Female KW - Pregnancy KW - Fetus -- drug effects KW - Pregnancy Complications -- drug therapy KW - Abnormalities, Drug-Induced -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558526278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Developing+a+systematic+approach+to+safer+medication+use+during+pregnancy%3A+summary+of+a+Centers+for+Disease+Control+and+Prevention--convened+meeting.&rft.au=Broussard%2C+Cheryl+S%3BFrey%2C+Meghan+T%3BHernandez-Diaz%2C+Sonia%3BGreene%2C+Michael+F%3BChambers%2C+Christina+D%3BSahin%2C+Leyla%3BCollins+Sharp%2C+Beth+A%3BHonein%2C+Margaret+A&rft.aulast=Broussard&rft.aufirst=Cheryl&rft.date=2014-09-01&rft.volume=211&rft.issue=3&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/10.1016%2Fj.ajog.2014.05.040 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-22 N1 - Date created - 2014-08-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Teratology. 1994 Jun;49(6):446-7 [7747265] J Womens Health (Larchmt). 2005 Mar;14(2):104-9 [15775727] Clin Perinatol. 2005 Sep;32(3):523-59 [16085019] Best Pract Res Clin Gastroenterol. 2007;21(5):755-69 [17889806] MMWR Surveill Summ. 2007 Dec 14;56(10):1-35 [18075488] Clin Pharmacol Ther. 2008 Jan;83(1):181-3 [18073777] BMJ. 2008 Apr 26;336(7650):924-6 [18436948] Med Ref Serv Q. 2008 Spring;27(1):73-80 [18689204] Ann Intern Med. 2009 Jan 6;150(1):45-9 [19124820] Birth Defects Res A Clin Mol Teratol. 2009 Feb;85(2):137-50 [19161158] Birth Defects Res A Clin Mol Teratol. 2009 Mar;85(3):193-201 [19086018] Curr Pain Headache Rep. 2009 Oct;13(5):392-8 [19728967] Ann Pharmacother. 2010 Mar;44(3):456-61 [20164469] Birth. 2010 Jun;37(2):106-15 [20557533] MMWR Recomm Rep. 2010 Nov 19;59(RR-10):1-36 [21088663] MMWR Recomm Rep. 2010 Dec 17;59(RR-12):1-110 [21160459] Obstet Gynecol. 2011 Apr;117(4):1019-27 [21422882] Am J Med Genet C Semin Med Genet. 2011 Aug 15;157C(3):175-82 [21766440] Vaccine. 2011 Nov 15;29(49):9171-6 [21839794] Am J Obstet Gynecol. 2011 Jul;205(1):51.e1-8 [21514558] Pediatrics. 2011 Sep;128(3):611-6 [21807694] Hum Reprod Update. 2012 Jul;18(4):360-73 [22431565] J Womens Health (Larchmt). 2012 Aug;21(8):830-6 [22691031] Birth Defects Res A Clin Mol Teratol. 2012 Aug;94(8):670-6 [22786781] Pharmacoepidemiol Drug Saf. 2013 Sep;22(9):1013-8 [23893932] Fed Regist. 2014 Dec 4;79(233):72063-103 [25509060] Comment In: Am J Obstet Gynecol. 2015 Jul;213(1):116 [25557207] Am J Obstet Gynecol. 2015 Jul;213(1):115-6 [25555661] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.ajog.2014.05.040 ER - TY - JOUR T1 - Tissue-specific microRNA responses in rats treated with mutagenic and carcinogenic doses of aristolochic acid. AN - 1555625805; 25106556 AB - Aristolochic acid (AA) is an active component in herbal drugs derived from the Aristolochia species. Although these drugs have been used since antiquity, AA is both genotoxic and carcinogenic in animals and humans, resulting in kidney tumours in rats and upper urinary tract tumours in humans. In the present study, we conducted microarray analysis of microRNA (miRNA) expression in tissues from transgenic Big Blue rats that were treated for 12 weeks with 0.1-10mg/kg AA, using a protocol that previous studies indicate eventually results in kidney tumours and mutations in kidney and liver. Global analysis of miRNA expression of rats treated with 10 mg/kg AA indicated that 19 miRNAs were significantly dysregulated in the kidney, with most of the miRNAs related to carcinogenesis. Only one miRNA, miR-34a (a tumour suppressor), was differentially expressed in the liver. The expression of the two most responsive kidney miRNAs (miR-21, an oncomiR and miR-34a) was further examined in the kidney, liver and testis of rats exposed to 0, 0.1, 1.0 and 10mg/kg AA. Expression of miR-21 was up-regulated in the kidney only, while miR-34a was dose-dependently up-regulated in both the kidney and liver; the expression of miR-21 and miR-34a was unaltered by the AA treatment in the testis. Analysis of cII mutations in the testis of treated rats also was negative. Our results indicate that AA treatment of rats produced dysregulation of a large number of miRNAs in the tumour target tissue and that the up-regulation of miR-21 correlated with the carcinogenicity of AA while the up-regulation of miR-34a correlated with its mutagenicity. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society 2014. JF - Mutagenesis AU - Meng, Fanxue AU - Li, Zhiguang AU - Yan, Jian AU - Manjanatha, Mugimane AU - Shelton, Sharon AU - Yarborough, Stephanie AU - Chen, Tao AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, 9 Lvshun Road South, Dalian, Liaoning 116044, China and Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA. ; Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, 9 Lvshun Road South, Dalian, Liaoning 116044, China and. ; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA. ; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA, Institute of Cancer Stem Cell, Cancer Center, Dalian Medical University, 9 Lvshun Road South, Dalian, Liaoning 116044, China and Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA tao.chen@fda.hhs.gov. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 357 EP - 365 VL - 29 IS - 5 KW - Aristolochic Acids KW - 0 KW - Carcinogens KW - MIRN34 microRNA, rat KW - MicroRNAs KW - Mutagens KW - mirn21 microRNA, rat KW - aristolochic acid I KW - 94218WFP5T KW - Index Medicus KW - Rats KW - Animals KW - Testis -- metabolism KW - Rats, Transgenic KW - Testis -- drug effects KW - Liver -- drug effects KW - Microarray Analysis KW - Kidney -- drug effects KW - Up-Regulation KW - Male KW - DNA Damage -- drug effects KW - MicroRNAs -- metabolism KW - Aristolochic Acids -- administration & dosage KW - MicroRNAs -- genetics KW - Aristolochic Acids -- toxicity KW - Carcinogens -- toxicity KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1555625805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Tissue-specific+microRNA+responses+in+rats+treated+with+mutagenic+and+carcinogenic+doses+of+aristolochic+acid.&rft.au=Meng%2C+Fanxue%3BLi%2C+Zhiguang%3BYan%2C+Jian%3BManjanatha%2C+Mugimane%3BShelton%2C+Sharon%3BYarborough%2C+Stephanie%3BChen%2C+Tao&rft.aulast=Meng&rft.aufirst=Fanxue&rft.date=2014-09-01&rft.volume=29&rft.issue=5&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=1464-3804&rft_id=info:doi/10.1093%2Fmutage%2Fgeu027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-11 N1 - Date created - 2014-08-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/mutage/geu027 ER - TY - GEN T1 - Predicting idiosyncratic drug-induced liver injury: some recent advances. AN - 1555247612; 24857265 AB - Drug-induced liver injury (DILI) is a major challenge for the pharmaceutical industry, regulatory authorities, and clinicians. It is usually categorized into 'intrinsic' and 'idiosyncratic', but DILI caused by most drugs is of an idiosyncratic nature and usually cannot be predicted from the regulatory required animal toxicity studies. Unfortunately, some individuals exposed to therapeutic dose will develop idiosyncratic DILI that might involve severe clinical outcome, and no biomarker is available to identify the susceptible patients prior to drug treatment. In this editorial, we summarized the recent advances in predicting idiosyncratic DILI and provided the perspectives to improve the prediction. JF - Expert review of gastroenterology & hepatology AU - Chen, Minjun AU - Borlak, Jürgen AU - Tong, Weida Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 721 EP - 723 VL - 8 IS - 7 KW - Biomarkers KW - 0 KW - HLA-B Antigens KW - HLA-B*57:01 antigen KW - Floxacillin KW - 43B2M34G2V KW - Transaminases KW - EC 2.6.1.- KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - predictive model KW - idiosyncratic drug-induced liver injury KW - data integration KW - HLA KW - drug safety KW - Animals KW - Diagnostic Tests, Routine KW - Humans KW - Disease Models, Animal KW - Predictive Value of Tests KW - Models, Biological KW - Genotype KW - Transaminases -- blood KW - Genetic Testing KW - HLA-B Antigens -- genetics KW - Pharmacogenetics -- trends KW - Risk Factors KW - Floxacillin -- adverse effects KW - Bilirubin -- blood KW - Biomarkers -- blood KW - Chemical and Drug Induced Liver Injury -- epidemiology KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Chemical and Drug Induced Liver Injury -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1555247612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+review+of+gastroenterology+%26+hepatology&rft.atitle=Predicting+idiosyncratic+drug-induced+liver+injury%3A+some+recent+advances.&rft.au=Chen%2C+Minjun%3BBorlak%2C+J%C3%BCrgen%3BTong%2C+Weida&rft.aulast=Chen&rft.aufirst=Minjun&rft.date=2014-09-01&rft.volume=8&rft.issue=7&rft.spage=721&rft.isbn=&rft.btitle=&rft.title=Expert+review+of+gastroenterology+%26+hepatology&rft.issn=1747-4132&rft_id=info:doi/10.1586%2F17474124.2014.922871 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-11 N1 - Date created - 2014-08-20 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1586/17474124.2014.922871 ER - TY - JOUR T1 - Prevalence of enterotoxins and toxin gene profiles of Staphylococcus aureus isolates recovered from a bakery involved in a second staphylococcal food poisoning occurrence. AN - 1554459880; 24917203 AB - The study objective was to characterize and analyse the distribution of enterotoxins and genes encoding enterotoxins in Staphylococcus aureus strains recovered from the 601 environment and ingredient samples obtained during multiple inspections of a bakery implicated in two separate staphylococcal food poisoning incidents. Staphylococcus aureus isolates were evaluated using serological assays for identification of classical staphylococcal enterotoxins (SEs) SEA-SEE and polymerase chain reaction for the detection of newly described SE and SE-like enterotoxin genes seg-seu. Pulsed field gel electrophoresis identified thirteen pattern types. During these investigations, a total of 585 environmental swabs and 16 raw ingredient samples were collected by investigators, 85 of which were confirmed to contain Staph. aureus; of those isolates, 95·3% (81/85) harboured enterotoxin genes and 4·7% (4/85) carried newly described SE and SE-like enterotoxin genes in the absence of classical enterotoxins. Our research demonstrates the prevalence and diversity of classical SEs and the probable underestimated impact of nonclassical SE and SE-like enterotoxins role in domestic staphylococcal food poisoning outbreaks. Given the abundance of SEs and SE-like toxins, these findings illustrate the utilization of PCR for enterotoxin gene identification and its significance in outbreak investigations. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of applied microbiology AU - Hait, J AU - Tallent, S AU - Melka, D AU - Keys, C AU - Bennett, R AD - Food and Drug Administration, College Park, MD, USA. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 866 EP - 875 VL - 117 IS - 3 KW - Enterotoxins KW - 0 KW - Index Medicus KW - staphylococcal enterotoxins KW - food safety KW - multiplex PCR KW - Staphylococcus aureus KW - PFGE KW - Polymerase Chain Reaction KW - Food Microbiology KW - Humans KW - Electrophoresis, Gel, Pulsed-Field KW - Disease Outbreaks KW - Staphylococcal Food Poisoning -- epidemiology KW - Staphylococcus aureus -- isolation & purification KW - Staphylococcus aureus -- genetics KW - Enterotoxins -- genetics KW - Staphylococcal Food Poisoning -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1554459880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+microbiology&rft.atitle=Prevalence+of+enterotoxins+and+toxin+gene+profiles+of+Staphylococcus+aureus+isolates+recovered+from+a+bakery+involved+in+a+second+staphylococcal+food+poisoning+occurrence.&rft.au=Hait%2C+J%3BTallent%2C+S%3BMelka%2C+D%3BKeys%2C+C%3BBennett%2C+R&rft.aulast=Hait&rft.aufirst=J&rft.date=2014-09-01&rft.volume=117&rft.issue=3&rft.spage=866&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+microbiology&rft.issn=1365-2672&rft_id=info:doi/10.1111%2Fjam.12571 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-24 N1 - Date created - 2014-08-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/jam.12571 ER - TY - JOUR T1 - Parasitic infections on the shore of Lake Victoria (East Africa) detected by Mini-FLOTAC and standard techniques AN - 1551615814; 20302022 AB - Background: Helminths and protozoa infections pose a great burden especially in developing countries, due to morbidity caused by both acute and chronic infection. The aim of our survey was to analyze the intestinal parasitic burden in communities from Mwanza region, Tanzania. Methods: Subjects (n = 251) from four villages on the South of Lake Victoria have been analyzed for intestinal parasites with direct smear (DS), formol-ether concentration method (FECM) and the newly developed Mini-FLOTAC technique; urinary schistosomiasis was also assessed in a subsample (n = 151); symptoms were registered and correlation between clinic and infections was calculated by chi-squared test and logistical regression. Results: Out of the subjects screened for intestinal and for urinary parasites, 87% (218/251) were found positive for any infection, 69% (174/251) carried a helminthic and 67% (167/251) a protozoan infection, almost half of them had a double or triple infection. The most common helminths were hookworms, followed by Schistosoma mansoni and Schistosoma haematobium. Among protozoa, the most common was Entamoeba coli followed by Entamoeba histolytica/dispar and Giardia intestinalis. Mini-FLOTAC detected a number of helminth infections (61.7%) higher than FECM (38.6%) and DS (17.9%). Some positive associations with abdominal symptoms were found and previous treatment was negatively correlated with infection. Conclusion: Despite the limited size of the examined population the current study indicates a high prevalence of intestinal parasitic infection in Bukumbi area, Tanzania, and Mini-FLOTAC showed to be a promising diagnostic tool for helminth infections. This high parasitic burden calls for starting a regular deworming programme and other preventive interventions in schools and in the community. JF - Acta Tropica AU - Barda, Beatrice AU - Ianniello, Davide AU - Zepheryne, Henry AU - Rinaldi, Laura AU - Cringoli, Giuseppe AU - Burioni, Roberto AU - Albonico, Marco Y1 - 2014/09/01/ PY - 2014 DA - 2014 Sep 01 SP - 140 EP - 146 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 137 SN - 0001-706X, 0001-706X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Intestinal parasitic infections KW - Helminths KW - Protozoa KW - Tanzania KW - Schistosoma mansoni KW - Parasites KW - Symptoms KW - Schistosoma haematobium KW - Disease control KW - Shores KW - Giardia intestinalis KW - Morbidity KW - Public health KW - Lakes KW - Intestines KW - Entamoeba histolytica KW - Population studies KW - Schistosomiasis KW - Tanzania, Mwanza KW - Education establishments KW - Intestinal parasites KW - Africa, Victoria L. KW - Chronic infection KW - Intestine KW - Developing countries KW - Entamoeba coli KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551615814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Tropica&rft.atitle=Parasitic+infections+on+the+shore+of+Lake+Victoria+%28East+Africa%29+detected+by+Mini-FLOTAC+and+standard+techniques&rft.au=Barda%2C+Beatrice%3BIanniello%2C+Davide%3BZepheryne%2C+Henry%3BRinaldi%2C+Laura%3BCringoli%2C+Giuseppe%3BBurioni%2C+Roberto%3BAlbonico%2C+Marco&rft.aulast=Barda&rft.aufirst=Beatrice&rft.date=2014-09-01&rft.volume=137&rft.issue=&rft.spage=140&rft.isbn=&rft.btitle=&rft.title=Acta+Tropica&rft.issn=0001706X&rft_id=info:doi/10.1016%2Fj.actatropica.2014.05.012 L2 - http://www.sciencedirect.com/science/article/pii/S0001706X14001879 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-08-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Symptoms; Parasites; Intestines; Disease control; Schistosomiasis; Developing countries; Education establishments; Public health; Lakes; Protozoa; Chronic infection; Intestine; Population studies; Shores; Intestinal parasites; Morbidity; Schistosoma mansoni; Entamoeba histolytica; Schistosoma haematobium; Giardia intestinalis; Entamoeba coli; Africa, Victoria L.; Tanzania; Tanzania, Mwanza DO - http://dx.doi.org/10.1016/j.actatropica.2014.05.012 ER - TY - JOUR T1 - Cytotoxic evaluation of nanostructured zinc oxide (ZnO) thin films and leachates. AN - 1542649056; 24878115 AB - Nanostructured ZnO films have potential use as coatings on medical devices and food packaging due to their antimicrobial and UV-protection properties. However, their influence on mammalian cells during clinical use is not fully understood. This study investigated the potential cytotoxicity of ZnO thin films in RAW 264.7 macrophages. ZnO thin films (∼96nm thick with a 50nm grain) were deposited onto silicon wafers using pulsed laser deposition. Cells grown directly on ZnO thin film coatings exhibited less toxicity than cells exposed to extracts of the coatings. Cells on ZnO thin films exhibited a 43% and 68% decrease in cell viability using the MTT and 7-AAD/Annexin V flow cytometry assays, respectively, after a 24-h exposure as compared to controls. Undiluted 100% 24- and 48-h extracts decreased viability by 89%, increased cell death by LDH release to 76% 24h after treatment, and increased ROS after 5-24h of exposure. In contrast, no cytotoxicity or ROS were observed for 25% and 50% extracts, indicating a tolerable concentration. Roughly 24 and 34μg/m(2) Zn leached off the surfaces after 24 and 48h of incubation, respectively. ZnO coatings may produce gradual ion release which becomes toxic after a certain level and should be evaluated using both direct exposure and extraction methods. Published by Elsevier Ltd. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Petrochenko, Peter E AU - Zhang, Qin AU - Bayati, Reza AU - Skoog, Shelby A AU - Phillips, K Scott AU - Kumar, Girish AU - Narayan, Roger J AU - Goering, Peter L AD - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD 20993, USA; Joint Dept of Biomedical Engineering, Univ of North Carolina-Chapel Hill and North Carolina State Univ, Raleigh, NC 27695, USA. ; Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD 20993, USA. ; Intel Corporation, IMO-SC, SC2, Santa Clara, CA 95052, USA. ; Joint Dept of Biomedical Engineering, Univ of North Carolina-Chapel Hill and North Carolina State Univ, Raleigh, NC 27695, USA. ; Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD 20993, USA. Electronic address: Peter.Goering@fda.hhs.gov. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 1144 EP - 1152 VL - 28 IS - 6 KW - Zinc Oxide KW - SOI2LOH54Z KW - Index Medicus KW - Nanoroughness KW - Zinc oxide (ZnO) KW - Pulsed laser deposition KW - Metal leaching KW - Macrophage KW - Surface toxicity KW - Animals KW - Necrosis KW - Cell Survival -- drug effects KW - Apoptosis -- drug effects KW - Mice KW - Cell Line KW - Nanostructures -- chemistry KW - Zinc Oxide -- toxicity KW - Zinc Oxide -- chemistry KW - Nanostructures -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1542649056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Cytotoxic+evaluation+of+nanostructured+zinc+oxide+%28ZnO%29+thin+films+and+leachates.&rft.au=Petrochenko%2C+Peter+E%3BZhang%2C+Qin%3BBayati%2C+Reza%3BSkoog%2C+Shelby+A%3BPhillips%2C+K+Scott%3BKumar%2C+Girish%3BNarayan%2C+Roger+J%3BGoering%2C+Peter+L&rft.aulast=Petrochenko&rft.aufirst=Peter&rft.date=2014-09-01&rft.volume=28&rft.issue=6&rft.spage=1144&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2014.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-19 N1 - Date created - 2014-07-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2014.05.004 ER - TY - JOUR T1 - Increased expression of Toll-like receptors (TLRs) 7 and 9 and other cytokines in systemic lupus erythematosus (SLE) patients: ethnic differences and potential new targets for therapeutic drugs. AN - 1532479718; 24865418 AB - Increased expression of pro-inflammatory cytokines such as interferon, tumor necrosis factors (TNFs) and specific interleukins (ILs) has been found in a number of autoimmune diseases, including systemic lupus erythematous (SLE). These cytokines are induced by toll-like receptors (TLRs). Toll-like receptors are activated in response to accumulation of apoptotic bodies. These receptors play critical roles in innate immune systems. Increased levels of interferon-alpha (INF-α) have also been found in many SLE patients and often correlate with disease severity. The objectives of this study were to examine the expression of selected TLRs and cytokines that have been identified in animal models and some limited human studies in a group of African Americans (AA) and European Americans (EA) women with lupus in comparison to age-matched non-lupus women. Blood samples were consecutively obtained by informed consent from 286 patients, 153 lupus and 136 non-lupus, seen in the rheumatology clinics at East Carolina University. Cytokines were analyzed from blood serum using enzyme linked immunoassay (ELISA) for IL-6 and INF-α. Total RNA was isolated, using a Paxgene kit, from peripheral blood mononuclear cells of African American and European American women blood samples. Quantitative real-time PCR using the CFX real-time system was conducted on all samples to determine TLRs 7 and 9, as well as INF-α expression. Toll-like receptor 7 (p<0.01) and 9 (p=0.001) expression levels were significantly increased in lupus patients compared to age-matched controls. African American women with lupus had a 2-fold increase in TLR-9 expression level when compared to their healthy controls or European American lupus patients. However, there was no ethnic difference in expression of TLR-7 in lupus patients. INF-α expression was significantly higher in lupus patients (p<0.0001) and also showed ethnic difference in expression. Serum levels revealed significant increases in expression of IL-6, IFN-γ and TNF-α in lupus patients compared to non-lupus patients. African American women with lupus had significantly higher serum levels of IL-6 and TNF-α. African American women with lupus demonstrated increased levels of specific pro-inflammatory cytokines and Toll-like receptors when compared to EA women. Increased expression in these lupus patients provides an opportunity for targeting with antagonist as a new therapy for systemic lupus erythematous. Published by Elsevier Ltd. JF - Molecular immunology AU - Lyn-Cook, Beverly D AU - Xie, Chenghui AU - Oates, Jarren AU - Treadwell, Edward AU - Word, Beverly AU - Hammons, George AU - Wiley, Kenneth AD - FDA-National Center for Toxicological Research, Jefferson, AR, United States. Electronic address: Beverly.lyn-cook@fda.hhs.gov. ; FDA-National Center for Toxicological Research, Jefferson, AR, United States. ; University of Arkansas at Pine Bluff, United States. ; East Carolina Brody School of Medicine, Greenville, NC, United States. Y1 - 2014/09// PY - 2014 DA - September 2014 SP - 38 EP - 43 VL - 61 IS - 1 KW - Interferon-alpha KW - 0 KW - Interleukin-6 KW - TLR7 protein, human KW - Toll-Like Receptor 7 KW - Toll-Like Receptor 9 KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - African American women KW - Systemic lupus erythematous KW - Tumor necrosis factor alpha KW - Interferon gamma KW - Toll-like receptors KW - Interleukin-6 -- blood KW - Cells, Cultured KW - Humans KW - Enzyme-Linked Immunosorbent Assay KW - Tumor Necrosis Factor-alpha -- blood KW - African Americans -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - European Continental Ancestry Group -- genetics KW - Female KW - Toll-Like Receptor 9 -- genetics KW - Lupus Erythematosus, Systemic -- ethnology KW - Lupus Erythematosus, Systemic -- genetics KW - Lupus Erythematosus, Systemic -- blood KW - Gene Expression KW - Interferon-alpha -- genetics KW - Interferon-alpha -- blood KW - Toll-Like Receptor 7 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1532479718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+immunology&rft.atitle=Increased+expression+of+Toll-like+receptors+%28TLRs%29+7+and+9+and+other+cytokines+in+systemic+lupus+erythematosus+%28SLE%29+patients%3A+ethnic+differences+and+potential+new+targets+for+therapeutic+drugs.&rft.au=Lyn-Cook%2C+Beverly+D%3BXie%2C+Chenghui%3BOates%2C+Jarren%3BTreadwell%2C+Edward%3BWord%2C+Beverly%3BHammons%2C+George%3BWiley%2C+Kenneth&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2014-09-01&rft.volume=61&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Molecular+immunology&rft.issn=1872-9142&rft_id=info:doi/10.1016%2Fj.molimm.2014.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-08-15 N1 - Date created - 2014-06-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.molimm.2014.05.001 ER - TY - JOUR T1 - A metallo-β-lactamase is responsible for the degradation of ceftiofur by the bovine intestinal bacterium Bacillus cereus P41. AN - 1549181620; 24972871 AB - Ceftiofur is a highly effective veterinary cephalosporin, yet it is rapidly degraded by bacteria in the gut. The goal of this work was to directly determine the mechanism of ceftiofur degradation by the bovine intestinal isolate Bacillus cereus P41. B. cereus P41 was isolated from the feces of a cow that had not been treated with cephalosporins, and was found to rapidly degrade ceftiofur in culture. Analysis of spent culture media by HPLC/UV and HPLC/MS revealed one major metabolite of ceftiofur, with a negative ion m/z of 127. Comparison of ceftiofur, ceftriaxone, and cefpodoxime degradation suggested that the major stable ceftiofur metabolite was the thiofuroic acid group eliminated from the C-3 position of the drug after hydrolysis by β-lactamase. Genomic DNA from B. cereus P41 was cloned into Escherichia coli, and the transformants were screened for growth in the presence of ceftiofur. DNA sequencing of the plasmid pHSG299-BC-3 insert revealed the presence of a gene encoding a metallo-β-lactamase. Incubation of ceftiofur with either the E. coli transformant or a commercial B. cereus metallo-β-lactamase showed degradation of the drug and formation of the same major metabolite produced by B. cereus P41. These data demonstrate that a metallo-β-lactamase plays a major role in the degradation of ceftiofur by the bovine intestinal bacterium B. cereus P41. Published by Elsevier B.V. JF - Veterinary microbiology AU - Erickson, Bruce D AU - Elkins, Christopher A AU - Mullis, Lisa B AU - Heinze, Thomas M AU - Wagner, R Doug AU - Cerniglia, Carl E AD - Division of Microbiology, National Center for Toxicological Research, Jefferson, AR, United States. Electronic address: bruce.erickson@fda.hhs.gov. ; Division of Microbiology, National Center for Toxicological Research, Jefferson, AR, United States. ; Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, United States. Y1 - 2014/08/27/ PY - 2014 DA - 2014 Aug 27 SP - 499 EP - 504 VL - 172 IS - 3-4 KW - Cephalosporins KW - 0 KW - cefpodoxime KW - 7R4F94TVGY KW - ceftiofur KW - 83JL932I1C KW - Ceftizoxime KW - C43C467DPE KW - beta-Lactamases KW - EC 3.5.2.6 KW - Index Medicus KW - Veterinary drugs KW - Biodegradation KW - Mass spectrometry KW - Drug residues KW - Feces -- microbiology KW - Animals KW - Cattle KW - Gene Expression Regulation, Enzymologic KW - Ceftizoxime -- analogs & derivatives KW - Drug Resistance, Bacterial KW - Female KW - Cloning, Molecular KW - Ceftizoxime -- metabolism KW - Cephalosporins -- pharmacology KW - Gene Expression Regulation, Bacterial -- physiology KW - Bacillus cereus -- enzymology KW - Bacillus cereus -- genetics KW - Bacillus cereus -- drug effects KW - beta-Lactamases -- classification KW - Cephalosporins -- metabolism KW - beta-Lactamases -- metabolism KW - Intestines -- microbiology KW - beta-Lactamases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1549181620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+microbiology&rft.atitle=A+metallo-%CE%B2-lactamase+is+responsible+for+the+degradation+of+ceftiofur+by+the+bovine+intestinal+bacterium+Bacillus+cereus+P41.&rft.au=Erickson%2C+Bruce+D%3BElkins%2C+Christopher+A%3BMullis%2C+Lisa+B%3BHeinze%2C+Thomas+M%3BWagner%2C+R+Doug%3BCerniglia%2C+Carl+E&rft.aulast=Erickson&rft.aufirst=Bruce&rft.date=2014-08-27&rft.volume=172&rft.issue=3-4&rft.spage=499&rft.isbn=&rft.btitle=&rft.title=Veterinary+microbiology&rft.issn=1873-2542&rft_id=info:doi/10.1016%2Fj.vetmic.2014.05.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-10 N1 - Date created - 2014-07-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.vetmic.2014.05.032 ER - TY - JOUR T1 - Comparison of two Gram stain point-of-care systems for urogenital gonorrhoea among high-risk patients: diagnostic accuracy and cost-effectiveness before and after changing the screening algorithm at an STI clinic in Amsterdam AN - 1827929693; PQ0003439676 AB - ObjectivesTo compare point-of-care (POC) systems in two different periods: (1) before 2010 when all high-risk patients were offered POC management for urogenital gonorrhoea by Gram stain examination; and (2) after 2010 when only those with symptoms were offered Gram stain examination.MethodsRetrospective comparison of a Gram stain POC system to all high-risk patients (2008-2009) with only those with urogenital symptoms (2010-2011) on diagnostic accuracy, loss to follow-up, presumptively and correctly treated infections and diagnostic costs. Culture was the reference diagnostic method.ResultsIn men the sensitivity of the Gram stain was 95.9% (95% CI 93.1% to 97.8%) in 2008-2009 and 95.4% (95% CI 93.7% to 96.8%) in 2010-2011, and in women the sensitivity was 32.0% (95% CI 19.5% to 46.7%) and 23.1% (95% CI 16.1% to 31.3%), respectively. In both periods the overall specificity was high (99.9% (95% CI 99.8% to 100%) and 99.8% (95% CI 99.7% to 99.9%), respectively). The positive predictive value (PPV) and negative predictive value (NPV) before and after 2010 were also high: PPV 97.0% (95% CI 94.5% to 98.5%) and 97.7% (95% CI 96.3% to 98.6%), respectively; NPV 99.6% (95% CI 99.4% to 99.7%) and 98.8% (95% CI 98.5% to 99.0%), respectively. There were no differences between the two time periods in loss to follow-up (7.1% vs 7.0%). Offering Gram stains only to symptomatic high-risk patients as opposed to all high-risk patients saved [Euro2.34 per correctly managed consultation (a reduction of 7.7%).ConclusionsThe sensitivity of the Gram stain is high in men but low in women. When offered only to high-risk patients with urogenital symptoms, the cost per correctly managed consultation is reduced by 7.7% without a significant difference in accuracy and loss to follow-up. JF - Sexually Transmitted Infections AU - Bartelsman, M AU - Straetemans, M AU - Vaughan, K AU - Alba, S AU - van Rooijen, M S AU - Faber, W R AU - de Vries, H J C AD - STI Outpatient Clinic, Public Health Service of Amsterdam (GGD Amsterdam), , Amsterdam, The Netherlands Y1 - 2014/08/23/ PY - 2014 DA - 2014 Aug 23 SP - 358 EP - 362 PB - British Medical Association, BMA House Square London WC1H 9JP United Kingdom VL - 90 IS - 5 SN - 1368-4973, 1368-4973 KW - Microbiology Abstracts B: Bacteriology KW - Gram stain KW - Algorithms KW - Risk groups KW - Infection KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1827929693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+Transmitted+Infections&rft.atitle=Comparison+of+two+Gram+stain+point-of-care+systems+for+urogenital+gonorrhoea+among+high-risk+patients%3A+diagnostic+accuracy+and+cost-effectiveness+before+and+after+changing+the+screening+algorithm+at+an+STI+clinic+in+Amsterdam&rft.au=Bartelsman%2C+M%3BStraetemans%2C+M%3BVaughan%2C+K%3BAlba%2C+S%3Bvan+Rooijen%2C+M+S%3BFaber%2C+W+R%3Bde+Vries%2C+H+J+C&rft.aulast=Bartelsman&rft.aufirst=M&rft.date=2014-08-23&rft.volume=90&rft.issue=5&rft.spage=358&rft.isbn=&rft.btitle=&rft.title=Sexually+Transmitted+Infections&rft.issn=13684973&rft_id=info:doi/10.1136%2Fsextrans-2013-051500 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-10-12 N1 - SubjectsTermNotLitGenreText - Gram stain; Algorithms; Risk groups; Infection DO - http://dx.doi.org/10.1136/sextrans-2013-051500 ER - TY - JOUR T1 - Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells AN - 1654686363; PQ0001052570 AB - Background: The link between environmental estrogen exposure and defects in the female reproductive tract is well established. The phytoestrogen genistein is able to modulate uterine estrogen receptor (ER) activity, and dietary exposure is associated with uterine pathologies. Regulation of stress and immune functions by the glucocorticoid receptor (GR) is also an integral part of maintaining reproductive tract function; disruption of GR signaling by genistein may also have a role in the adverse effects of genistein. Objective: We evaluated the transcriptional response to genistein in Ishikawa cells and investigated the effects of genistein on GR-mediated target genes. Methods: We used Ishikawa cells as a model system to identify novel targets of genistein and the synthetic glucocorticoid dexamethasone through whole genome microarray analysis. Common gene targets were defined and response patterns verified by quantitative real-time reverse-transcription polymerase chain reaction. The mechanism of transcriptional antagonism was determined for select genes. Results: Genistein regulated numerous genes in Ishikawa cells independently of estradiol, and the response to coadministration of genistein and dexamethasone was unique compared with the response to either estradiol or dexamethasone alone. Furthermore, genistein altered glucocorticoid regulation of GR target genes. In a select set of genes, co-regulation by dexamethasone and genistein was found to require both GR and ER alpha signaling, respectively. Conclusions: Using Ishikawa cells, we observed that exposure to genistein resulted in distinct changes in gene expression and unique differences in the GR transcriptome. Citation: Whirledge S, Senbanjo LT, Cidlowski JA. 2015. Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect 123:80-87; http://dx.doi.org/10.1289/ehp.1408437 JF - Environmental Health Perspectives AU - Whirledge, Shannon AU - Senbanjo, Linda T AU - Cidlowski, John A AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2014/08/19/ PY - 2014 DA - 2014 Aug 19 SP - 80 EP - 87 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 123 IS - 1 SN - 0091-6765, 0091-6765 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Diets KW - Estrogens KW - Pathology KW - Stress KW - Immune response KW - Antagonism KW - Side effects KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654686363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Genistein+Disrupts+Glucocorticoid+Receptor+Signaling+in+Human+Uterine+Endometrial+Ishikawa+Cells&rft.au=Whirledge%2C+Shannon%3BSenbanjo%2C+Linda+T%3BCidlowski%2C+John+A&rft.aulast=Whirledge&rft.aufirst=Shannon&rft.date=2014-08-19&rft.volume=123&rft.issue=1&rft.spage=80&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1408437 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Diets; Estrogens; Pathology; Stress; Antagonism; Immune response; Side effects DO - http://dx.doi.org/10.1289/ehp.1408437 ER - TY - JOUR T1 - Perfluorochemicals and Human Semen Quality: The LIFE Study AN - 1654688775; PQ0001052566 AB - Background: The relation between persistent environmental chemicals and semen quality is evolving, although limited data exist for men recruited from general populations. Objectives: We examined the relation between perfluorinated chemicals (PFCs) and semen quality among 501 male partners of couples planning pregnancy. Methods: Using population-based sampling strategies, we recruited 501 couples discontinuing contraception from two U.S. geographic regions from 2005 through 2009. Baseline interviews and anthropometric assessments were conducted, followed by blood collection for the quantification of seven serum PFCs (perfluorosulfonates, perfluorocarboxylates, and perfluorosulfonamides) using tandem mass spectrometry. Men collected a baseline semen sample and another approximately 1 month later. Semen samples were shipped with freezer packs, and analyses were performed on the day after collection. We used linear regression to estimate the difference in each semen parameter associated with a one unit increase in the natural log-transformed PFC concentration after adjusting for confounders and modeling repeated semen samples. Sensitivity analyses included optimal Box-Cox transformation of semen quality end points. Results: Six PFCs [2-(N-methyl-perfluorooctane sulfonamido) acetate (Me-PFOSA-AcOH), perfluorodecanoate (PFDeA), perfluorononanoate (PFNA), perfluorooctane sulfonamide (PFOSA), perfluorooctane sulfonate (PFOS), and perfluorooctanoic acid (PFOA)] were associated with 17 semen quality end points before Box-Cox transformation. PFOSA was associated with smaller sperm head area and perimeter, a lower percentage of DNA stainability, and a higher percentage of bicephalic and immature sperm. PFDeA, PFNA, PFOA, and PFOS were associated with a lower percentage of sperm with coiled tails. Conclusions: Select PFCs were associated with certain semen end points, with the most significant associations observed for PFOSA but with results in varying directions. Citation: Buck Louis GM, Chen Z, Schisterman EF, Kim S, Sweeney AM, Sundaram R, Lynch CD, Gore-Langton RE, Barr DB. 2015. Perfluorochemicals and human semen quality: the LIFE Study. Environ Health Perspect 123:57-63; http://dx.doi.org/10.1289/ehp.1307621 JF - Environmental Health Perspectives AU - Louis, Germaine MBuck AU - Chen, Zhen AU - Schisterman, Enrique F AU - Kim, Sungduk AU - Sweeney, Anne M AU - Sundaram, Rajeshwari AU - Lynch, Courtney D AU - Gore-Langton, Robert E AU - Barr, Dana Boyd AD - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA Y1 - 2014/08/15/ PY - 2014 DA - 2014 Aug 15 SP - 57 EP - 63 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 123 IS - 1 SN - 0091-6765, 0091-6765 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Chemicals KW - Sensitivity analysis KW - Sulfonates KW - DNA KW - Mass spectrometry KW - Cadmium KW - Pregnancy KW - ENA 13:Population Planning & Control KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654688775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Perfluorochemicals+and+Human+Semen+Quality%3A+The+LIFE+Study&rft.au=Louis%2C+Germaine+MBuck%3BChen%2C+Zhen%3BSchisterman%2C+Enrique+F%3BKim%2C+Sungduk%3BSweeney%2C+Anne+M%3BSundaram%2C+Rajeshwari%3BLynch%2C+Courtney+D%3BGore-Langton%2C+Robert+E%3BBarr%2C+Dana+Boyd&rft.aulast=Louis&rft.aufirst=Germaine&rft.date=2014-08-15&rft.volume=123&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1307621 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Chemicals; Sensitivity analysis; Sulfonates; DNA; Mass spectrometry; Cadmium; Pregnancy DO - http://dx.doi.org/10.1289/ehp.1307621 ER - TY - JOUR T1 - Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress AN - 1642628401; 21201989 AB - Background: Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP production but also through metabolites generated in the tricarboxylic acid cycle, as well as mitochondria-nuclear signaling related to mitochondria morphology, biogenesis, fission/fusion, mitophagy, apoptosis, and epigenetic regulation. Objectives: We investigated the concept of bidirectional interactions between mitochondria and cellular pathways in response to environmental stress with a focus on epigenetic regulation, and we examined DNA repair and DDR pathways as examples of biological processes that respond to exogenous insults through changes in homeostasis and altered mitochondrial function. Methods: The National Institute of Environmental Health Sciences sponsored the Workshop on Mitochondria, Energetics, Epigenetics, Environment, and DNA Damage Response on 25-26 March 2013. Here, we summarize key points and ideas emerging from this meeting. Discussion: A more comprehensive understanding of signaling mechanisms (cross-talk) between the mitochondria and nucleus is central to elucidating the integration of mitochondrial functions with other cellular response pathways in modulating the effects of environmental agents. Recent studies have highlighted the importance of mitochondrial functions in epigenetic regulation and DDR with environmental stress. Development and application of novel technologies, enhanced experimental models, and a systems-type research approach will help to discern how environmentally induced mitochondrial dysfunction affects key mechanistic pathways. Conclusions: Understanding mitochondria-cell signaling will provide insight into individual responses to environmental hazards, improving prediction of hazard and susceptibility to environmental stressors. Citation: Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. 2014. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect 122:1271-1278; http://dx.doi.org/10.1289/ehp.1408418 JF - Environmental Health Perspectives AU - Shaughnessy, Daniel T AU - McAllister, Kimberly AU - Worth, Leroy AU - Haugen, Astrid C AU - Meyer, Joel N AU - Domann, Frederick E AU - Van Houten, Bennett AU - Mostoslavsky, Raul AU - Bultman, Scott J AU - Baccarelli, Andrea A AU - Begley, Thomas J AU - Sobol, Robert W AU - Hirschey, Matthew D AU - Ideker, Trey AU - Santos, Janine H AU - Copeland, William C AU - Tice, Raymond R AU - Balshaw, David M AU - Tyson, Frederick L AD - Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA Y1 - 2014/08/15/ PY - 2014 DA - 2014 Aug 15 SP - 1271 EP - 1278 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 122 IS - 12 SN - 0091-6765, 0091-6765 KW - Biochemistry Abstracts 2: Nucleic Acids; Environment Abstracts KW - Prediction KW - Apoptosis KW - Environmental health KW - Mitochondria KW - Nutrients KW - Metabolites KW - Homeostasis KW - Integration KW - Reactive oxygen species KW - Environmental hazards KW - epigenetics KW - Environmental stress KW - Tricarboxylic acid cycle KW - Adenylate cyclase KW - Brazil, Sao Paulo, Santos KW - Conferences KW - ATP KW - DNA repair KW - Oxygen KW - DNA damage KW - Reviews KW - Morphology KW - DNA KW - Technology KW - Signal transduction KW - N 14820:DNA Metabolism & Structure KW - ENA 21:Wildlife UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642628401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Mitochondria%2C+Energetics%2C+Epigenetics%2C+and+Cellular+Responses+to+Stress&rft.au=Shaughnessy%2C+Daniel+T%3BMcAllister%2C+Kimberly%3BWorth%2C+Leroy%3BHaugen%2C+Astrid+C%3BMeyer%2C+Joel+N%3BDomann%2C+Frederick+E%3BVan+Houten%2C+Bennett%3BMostoslavsky%2C+Raul%3BBultman%2C+Scott+J%3BBaccarelli%2C+Andrea+A%3BBegley%2C+Thomas+J%3BSobol%2C+Robert+W%3BHirschey%2C+Matthew+D%3BIdeker%2C+Trey%3BSantos%2C+Janine+H%3BCopeland%2C+William+C%3BTice%2C+Raymond+R%3BBalshaw%2C+David+M%3BTyson%2C+Frederick+L&rft.aulast=Shaughnessy&rft.aufirst=Daniel&rft.date=2014-08-15&rft.volume=122&rft.issue=12&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1408418 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Apoptosis; Conferences; Mitochondria; ATP; Metabolites; Nutrients; Homeostasis; DNA repair; Integration; DNA damage; Reactive oxygen species; epigenetics; Reviews; Environmental stress; Tricarboxylic acid cycle; Signal transduction; Adenylate cyclase; Prediction; Oxygen; Environmental hazards; Morphology; DNA; Environmental health; Technology; Brazil, Sao Paulo, Santos DO - http://dx.doi.org/10.1289/ehp.1408418 ER - TY - JOUR T1 - Preconception Maternal and Paternal Exposure to Persistent Organic Pollutants and Birth Size: The LIFE Study AN - 1660066280; PQ0001052575 AB - Background: Persistent organic pollutants (POPs) are developmental toxicants, but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored. Objective: We examined associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutants, with birth size measures. Methods: Parental serum concentrations of 9 organochlorine pesticides, 1 polybrominated biphenyl (PBB), 7 perfluoroalkyl chemicals (PFCs), 10 polybrominated diphenyl ethers (PBDEs), and 36 polychlorinated biphenyls (PCBs) were measured before conception for 234 couples. Differences in birth weight, length, head circumference, and ponderal index were estimated using multiple linear regression per 1-SD increase in natural log-transformed (ln-transformed) chemicals. Models were estimated separately for each parent and adjusted for maternal age, maternal prepregnancy body mass index (kilograms per meter squared) and other confounders, and all models included an interaction term between infant sex and each chemical. Results: Among girls (n = 117), birth weight was significantly lower (range, 84-195 g) in association with a 1-SD increase in ln-transformed maternal serum concentrations of DDT, PBDE congeners 28 and 183, and paternal serum concentrations of PBDE-183 and PCB-167. Among boys (n = 113), maternal (PCBs 138, 153, 167, 170, 195, and 209 and perfluorooctane sulfonamide) and paternal (PCBs 172 and 195) serum concentrations of several POPs were statistically associated with lower birth weight (range, 98-170 g), whereas paternal concentrations of PBDEs (66, 99) were associated with higher birth weight. Differences in offspring head circumference, length, and ponderal index were also associated with parental exposures. Conclusions: Preconceptional maternal and paternal concentrations of several POPs were associated with statistically significant differences in birth size among offspring. Citation: Robledo CA, Yeung E, Mendola P, Sundaram R, Maisog J, Sweeney AM, Barr DB, Buck Louis GM. 2015. Preconception maternal and paternal exposure to persistent organic pollutants and birth size: the LIFE Study. Environ Health Perspect 123:88-94; http://dx.doi.org/10.1289/ehp.1308016 JF - Environmental Health Perspectives AU - Robledo, Candace A AU - Yeung, Edwina AU - Mendola, Pauline AU - Sundaram, Rajeshwari AU - Maisog, Jose AU - Sweeney, Anne M AU - Barr, Dana Boyd AU - Louis, Germaine MBuck AD - Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA Y1 - 2014/08/05/ PY - 2014 DA - 2014 Aug 05 SP - 88 EP - 94 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 123 IS - 1 SN - 0091-6765, 0091-6765 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Birth KW - Pollutants KW - Exposure KW - Circumferences KW - Health KW - Serums KW - Perfluoroalkyls KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660066280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Preconception+Maternal+and+Paternal+Exposure+to+Persistent+Organic+Pollutants+and+Birth+Size%3A+The+LIFE+Study&rft.au=Robledo%2C+Candace+A%3BYeung%2C+Edwina%3BMendola%2C+Pauline%3BSundaram%2C+Rajeshwari%3BMaisog%2C+Jose%3BSweeney%2C+Anne+M%3BBarr%2C+Dana+Boyd%3BLouis%2C+Germaine+MBuck&rft.aulast=Robledo&rft.aufirst=Candace&rft.date=2014-08-05&rft.volume=123&rft.issue=1&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1308016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-05-04 DO - http://dx.doi.org/10.1289/ehp.1308016 ER - TY - JOUR T1 - Acute effects of nonexcitatory electrical stimulation during systole in isolated cardiac myocytes and perfused heart AN - 1855077363; PQ0001958359 AB - Application of electrical field to the heart during the refractory period of the beat has been shown to increase the force of contraction both in animal models and in heart failure patients (cardiac contractility modulation, or CCM). A direct increase in intracellular calcium during CCM has been suggested to be the mechanism behind the positive inotropic effect of CCM. We studied the effect of CCM on isolated rabbit cardiomyocytes and perfused whole rat hearts. The effect of CCM was observed in single cells via fluorescent measurements of intracellular calcium concentration ([Ca super(2+)] sub(i)) and cell length (L). Cells were paced once per second throughout these recordings, and CCM stimulation was delivered via biphasic electric fields of 20 ms duration applied during the refractory period. CCM increased the peak amplitude of both [Ca super(2+)] sub(i) and L for the first beat during CCM compared to control, but then [Ca super(2+)] sub(i) and L decayed to levels lower than the control. During CCM, all contractions had a faster time to peak for both [Ca super(2+)] sub(i) and L; after stopping CCM the rise times returned to control levels. In the whole rat heart, the positive inotropic effect of CCM stimulation on left ventricular pressure was completely abolished in the presence of metoprolol, a beta-1 adrenergic blocker. In summary, the CCM-induced changes in intracellular calcium handling by cardiomyocytes did not explain the sustained positive inotropic effect in the whole heart and the beta -adrenergic pathway may be involved in the CCM mechanism of action. e12106 Cardiac contractility modulation (CCM) is a heart failure therapy which delivers electrical pulses to the heart during refractory period. While there are some promising reports on the therapy's safety and effectiveness in humans, the underlining mechanism remains unknown. We studied the effect of CCM pulses in isolated rabbit cardiomyocytes and isolated rat heart in the presence of beta adrenergic blocker and recorded intracellular calcium transients and contractions. We concluded that the CCM-induced changes in intracellular calcium handling by cardiomyocytes did not explain the sustained positive iotropic efect in the whole heart and beta-adrenergic pathway may be involved in the CCM mechanism of action. JF - Physiological Reports AU - Blinova, Ksenia AU - Stohlman, Jayna AU - Krauthamer, Victor AU - Knapton, Alan AU - Bloomquist, Erik AU - Gray, Richard A AD - Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - [np] PB - Wiley Subscription Services, Inc. VL - 2 IS - 8 SN - 2051-817X, 2051-817X KW - Toxicology Abstracts KW - Heart KW - Muscle contraction KW - Animal models KW - metoprolol KW - cardiomyocytes KW - Calcium (intracellular) KW - Acute effects KW - Electrical stimuli KW - Ventricle KW - Electric fields KW - Pressure KW - Heart diseases KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855077363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+Reports&rft.atitle=Acute+effects+of+nonexcitatory+electrical+stimulation+during+systole+in+isolated+cardiac+myocytes+and+perfused+heart&rft.au=Blinova%2C+Ksenia%3BStohlman%2C+Jayna%3BKrauthamer%2C+Victor%3BKnapton%2C+Alan%3BBloomquist%2C+Erik%3BGray%2C+Richard+A&rft.aulast=Blinova&rft.aufirst=Ksenia&rft.date=2014-08-01&rft.volume=2&rft.issue=8&rft.spage=%5Bnp%5D&rft.isbn=&rft.btitle=&rft.title=Physiological+Reports&rft.issn=2051817X&rft_id=info:doi/10.14814%2Fphy2.12106 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2017-01-01 N1 - Last updated - 2017-01-18 N1 - SubjectsTermNotLitGenreText - Acute effects; Heart; Electrical stimuli; Muscle contraction; Ventricle; Electric fields; Animal models; metoprolol; cardiomyocytes; Pressure; Heart diseases; Calcium (intracellular) DO - http://dx.doi.org/10.14814/phy2.12106 ER - TY - JOUR T1 - Interpretations on the content of the Guidance for Repetitive Dose Toxicity Testing AN - 1837324947; PQ0002533260 AB - In 2014, China Food and Drug Administration issued eight guidances on nonclinical safety studies, which included the Guidance for Repetitive Dose Toxicity Testing. The article introduces the background and the viewpoint. JF - Zhongguo Linchuang Yaolixue Zazhi - The Chinese Journal of Clinical Pharmacology AU - Da, Hong-yuan AU - Han, Ling AU - Wang, Qing-li AD - Center for Drug Evaluation, China Food and Drug Administration, Beijing 100061, China, dahy@cde.org.cn Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 744 EP - 745 PB - Zhongguo Linchuang Yaolixue Zazhi VL - 30 IS - 8 SN - 1001-6821, 1001-6821 KW - Toxicology Abstracts KW - guidance KW - repetitive dose toxicity test KW - interpret KW - Toxicity testing KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1837324947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zhongguo+Linchuang+Yaolixue+Zazhi+-+The+Chinese+Journal+of+Clinical+Pharmacology&rft.atitle=Interpretations+on+the+content+of+the+Guidance+for+Repetitive+Dose+Toxicity+Testing&rft.au=Da%2C+Hong-yuan%3BHan%2C+Ling%3BWang%2C+Qing-li&rft.aulast=Da&rft.aufirst=Hong-yuan&rft.date=2014-08-01&rft.volume=30&rft.issue=8&rft.spage=744&rft.isbn=&rft.btitle=&rft.title=Zhongguo+Linchuang+Yaolixue+Zazhi+-+The+Chinese+Journal+of+Clinical+Pharmacology&rft.issn=10016821&rft_id=info:doi/10.13699%2Fj.cnki.1001-6821.2014.08.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-11-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Toxicity testing DO - http://dx.doi.org/10.13699/j.cnki.1001-6821.2014.08.028 ER - TY - JOUR T1 - Assessment Standards: Comparing Histopathology, Digital Image Analysis, and Stereology for Early Detection of Experimental Cisplatin-induced Kidney Injury in Rats AN - 1683352010; PQ0001555051 AB - Histopathology generally represents the reference standard for performance evaluation of nonclinical biomarkers used to inform regulatory decision making. This study uses drug-induced nephrotoxicity in rats to evaluate histopathology methods utilized in biomarker performance assessments. Male Sprague-Dawley rats received a single dose of cisplatin (0.5-5.0 mg/kg, intraperitoneally) to produce mild renal injury. Animals were euthanized 72 hr postdose and perfusion fixed. Kidneys were processed for histology and stereology procedures. Kidney injury molecule-1 (Kim-1) was measured in urine and in kidney tissue. Digital slide images were generated and analyzed by pathologists after collaborating on a training set of glass slides and digital images. Image analysis identified immunohistochemistry (IHC)-defined tubular injury. Stereology methods yielded estimations of proximal tubular cell number and volume. Statistical relationships among data sets were determined using correlation coefficients. Receiver operator characteristic (ROC) analyses determined the effect of method on biomarker assessment. Urinary Kim-1 was strongly correlated with digital image analysis and secondarily to histopathology evaluations. Stereology demonstrated weak or no correlation to pathology and urinary Kim-1. In ROC analyses, semiquantitative evaluations determined higher values for urinary Kim-1 performance than did IHC-based qualitative digital analyses. Semiquantitative evaluation as used in this study was most predictive of urinary Kim-1 values. JF - Toxicologic Pathology AU - Shea, Katherine AU - Stewart, Sharron AU - Rouse, Rodney AD - Division of Drug Safety Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA, rodney.rouse@fda.hhs.gov Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 1004 EP - 1015 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 42 IS - 6 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - methods KW - kidney tissue injury KW - histopathology KW - digital image analysis KW - stereology. KW - Statistics KW - Data processing KW - Perfusion KW - Injuries KW - Cell number KW - Image processing KW - biomarkers KW - Decision making KW - Cisplatin KW - Urine KW - Kidney KW - Immunohistochemistry KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683352010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Assessment+Standards%3A+Comparing+Histopathology%2C+Digital+Image+Analysis%2C+and+Stereology+for+Early+Detection+of+Experimental+Cisplatin-induced+Kidney+Injury+in+Rats&rft.au=Shea%2C+Katherine%3BStewart%2C+Sharron%3BRouse%2C+Rodney&rft.aulast=Shea&rft.aufirst=Katherine&rft.date=2014-08-01&rft.volume=42&rft.issue=6&rft.spage=1004&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623313509905 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 29 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Decision making; Perfusion; Data processing; Statistics; Cisplatin; Cell number; Injuries; Urine; Kidney; Image processing; Immunohistochemistry; biomarkers DO - http://dx.doi.org/10.1177/0192623313509905 ER - TY - JOUR T1 - Farm residence and lymphohematopoietic cancers in the Iowa Women super(3)s Health Study AN - 1627967146; 20956907 AB - Background Cancer incidence in male farmers has been studied extensively; however, less is known about risk among women residing on farms or in agricultural areas, who may be exposed to pesticides by their proximity to crop fields. We extended a previous follow-up of the Iowa Women super(3)s Health Study cohort to examine farm residence and the incidence of lymphohematopoietic cancers. Further, we investigated crop acreage within 750m of residences, which has been associated with higher herbicide levels in Iowa homes. Methods We analyzed data for a cohort of 37,099 Iowa women aged 55-69 years who reported their residence location (farm, rural (not a farm), town size based on population) at enrollment in 1986. We identified incident lymphohematopoietic cancers (1986-2009) by linkage with the Iowa Cancer Registry. Using a geographic information system, we geocoded addresses and calculated acreage of pasture and row crops within 750m of homes using the 1992 National Land Cover Database. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) in multivariate analyses of cancer risk in relation to both residence location and crop acreage. Results As found in an earlier analysis of residence location, risk of acute myeloid leukemia (AML) was higher among women living on farms (HR=2.23, 95%CI: 1.25-3.99) or rural areas (but not on a farm) (HR=1.95, 95%CI: 0.89-4.29) compared with women living in towns of >10,000 population. We observed no association between farm or rural residence and non-Hodgkin lymphoma (NHL; overall or for major subtypes) or multiple myeloma. In analyses of crop acreage, we observed no association between pasture or row crop acreage within 750m of homes and risk of leukemia overall or for the AML subtype. Chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) risk was nonsignificantly elevated among women with pasture acreage within 750m of their home (HRs for increasing tertiles=1.8, 1.8 and 1.5) and with row crop acreage within 750m (HRs for increasing tertiles of acreage=1.4, 1.5 and 1.6) compared to women with no pasture or row crop acreage, respectively. Conclusions Iowa women living on a farm or in a rural area were at increased risk of developing AML, which was not related to crop acreage near the home. Living near pasture or row crops may confer an increased risk of CLL/SLL regardless of residence location. Further investigation of specific farm-related exposures and these cancers among women living on farms and in agricultural areas is warranted. JF - Environmental Research AU - Jones, Rena R AU - Yu, Chu-Ling AU - Nuckols, John R AU - Cerhan, James R AU - Airola, Matthew AU - Ross, Julie A AU - Robien, Kim AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 353 EP - 361 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 133 SN - 0013-9351, 0013-9351 KW - Risk Abstracts; Environment Abstracts KW - Farm residence KW - Pesticides KW - Iowa Women super(3)s Health Study KW - GIS KW - Land use KW - Farms KW - Crop fields KW - Remote sensing KW - Herbicides KW - Pasture KW - Towns KW - Cancer KW - Crops KW - Leukemia KW - Health risks KW - Multiple myeloma KW - USA, Iowa KW - Geographic information systems KW - Lymphoma KW - Rural areas KW - ENA 06:Food & Drugs KW - R2 23050:Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627967146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Research&rft.atitle=Farm+residence+and+lymphohematopoietic+cancers+in+the+Iowa+Women+super%283%29s+Health+Study&rft.au=Jones%2C+Rena+R%3BYu%2C+Chu-Ling%3BNuckols%2C+John+R%3BCerhan%2C+James+R%3BAirola%2C+Matthew%3BRoss%2C+Julie+A%3BRobien%2C+Kim%3BWard%2C+Mary+H&rft.aulast=Jones&rft.aufirst=Rena&rft.date=2014-08-01&rft.volume=133&rft.issue=&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Environmental+Research&rft.issn=00139351&rft_id=info:doi/10.1016%2Fj.envres.2014.05.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-04-16 N1 - SubjectsTermNotLitGenreText - Farms; Crop fields; Remote sensing; Herbicides; Pasture; Crops; Cancer; Towns; Health risks; Leukemia; Multiple myeloma; Geographic information systems; Lymphoma; Rural areas; USA, Iowa DO - http://dx.doi.org/10.1016/j.envres.2014.05.028 ER - TY - JOUR T1 - Benchmark dose calculation for ordered categorical responses AN - 1586105994; 4603563 AB - The use of benchmark dose (BMD) calculations for dichotomous or continuous responses is well established in the risk assessment of cancer and noncancer endpoints. In some cases, responses to exposure are categorized in terms of ordinal severity effects such as none, mild, adverse, and severe. Such responses can be assessed using categorical regression (CATREG) analysis. However, while CATREG has been employed to compare the benchmark approach and the no-adverse-effect-level (NOAEL) approach in determining a reference dose, the utility of CATREG for risk assessment remains unclear. This study proposes a CATREG model to extend the BMD approach to ordered categorical responses by modeling severity levels as censored interval limits of a standard normal distribution. The BMD is calculated as a weighted average of the BMDs obtained at dichotomous cutoffs for each adverse severity level above the critical effect, with the weights being proportional to the reciprocal of the expected loss at the cutoff under the normal probability model. This approach provides a link between the current BMD procedures for dichotomous and continuous data. We estimate the CATREG parameters using a Markov chain Monte Carlo simulation procedure. The proposed method is demonstrated using examples of aldicarb and urethane, each with several categories of severity levels. Simulation studies comparing the BMD and BMDL (lower confidence bound on the BMD) using the proposed method to the correspondent estimates using the existing methods for dichotomous and continuous data are quite compatible; the difference is mainly dependent on the choice of cutoffs for the severity levels. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Chen, Chu-chih AU - Chen, James J AD - National Health Research Institutes ; National Center for Toxicological Research Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 1435 EP - 1447 VL - 34 IS - 8 SN - 0272-4332, 0272-4332 KW - Economics KW - Monte Carlo simulation KW - Regression analysis KW - Estimation KW - Benchmarking KW - Risk theory KW - Markovian processes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1586105994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Benchmark+dose+calculation+for+ordered+categorical+responses&rft.au=Chen%2C+Chu-chih%3BChen%2C+James+J&rft.aulast=Chen&rft.aufirst=Chu-chih&rft.date=2014-08-01&rft.volume=34&rft.issue=8&rft.spage=1435&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Frisa.12167 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-10-06 N1 - Last updated - 2014-10-06 N1 - SubjectsTermNotLitGenreText - 1551; 7747 12265 3865 4025 10214 12224 971 12228 10919; 8268 12265 3865 4025 10214 12224 971 12228 10919; 4403 7854; 10739 12228 10919; 11040 11035 DO - http://dx.doi.org/10.1111/risa.12167 ER - TY - JOUR T1 - Interpreting MSHA Citations Through the Lens of Occupational Health and Safety Management Systems: Investigating Their Impact on Mine Injuries and Illnesses 2003-2010 AN - 1566833099; 20662334 AB - Since the late 1980s, the U.S. Department of Labor has considered regulating a systems approach to occupational health and safety management. Recently, a health and safety management systems (HSMS) standard has returned to the regulatory agenda of both the Occupational Safety and Health Administration (OSHA) and the Mine Safety and Health Administration (MSHA). Because a mandated standard has implications for both industry and regulating bodies alike, it is imperative to gain a greater understanding of the potential effects that an HSMS regulatory approach can have on establishment-level injuries and illnesses. Through the lens of MSHA's regulatory framework, we first explore how current enforcement activities align with HSMS elements. Using MSHA data for the years 2003-2010, we then analyze the relationship between various types of enforcement activities (e.g., total number of citations, total penalty amount, and HSMS-aligned citations) and mine reportable injuries. Our findings show that the reduction in mine reportable injuries predicted by increases in MSHA enforcement ranges from negligible to 18%. The results suggest that the type and focus of the enforcement activity may be more important for accident reduction than the total number of citations issued and the associated penalty amount. JF - Risk Analysis AU - Yorio, Patrick L AU - Willmer, Dana R AU - Haight, Joel M AD - CDC-NIOSH, Office of Mine Safety and Health Research, Pittsburgh, PA, USA. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 1538 EP - 1553 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 34 IS - 8 SN - 0272-4332, 0272-4332 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Federal regulations KW - Risk analysis KW - Safety regulations KW - Data processing KW - Injuries KW - Safety KW - Occupational safety KW - Mines KW - Accidents KW - Occupational health KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566833099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Interpreting+MSHA+Citations+Through+the+Lens+of+Occupational+Health+and+Safety+Management+Systems%3A+Investigating+Their+Impact+on+Mine+Injuries+and+Illnesses+2003-2010&rft.au=Yorio%2C+Patrick+L%3BWillmer%2C+Dana+R%3BHaight%2C+Joel+M&rft.aulast=Yorio&rft.aufirst=Patrick&rft.date=2014-08-01&rft.volume=34&rft.issue=8&rft.spage=1538&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Frisa.12164 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Accidents; Data processing; Injuries; Mines; Risk analysis; Federal regulations; Safety regulations; Occupational safety; Safety; Occupational health DO - http://dx.doi.org/10.1111/risa.12164 ER - TY - JOUR T1 - Validation and Application of Models to Predict Facemask Influenza Contamination in Healthcare Settings AN - 1566829428; 20662339 AB - Facemasks are part of the hierarchy of interventions used to reduce the transmission of respiratory pathogens by providing a barrier. Two types of facemasks used by healthcare workers are N95 filtering facepiece respirators (FFRs) and surgical masks (SMs). These can become contaminated with respiratory pathogens during use, thus serving as potential sources for transmission. However, because of the lack of field studies, the hazard associated with pathogen-exposed facemasks is unknown. A mathematical model was used to calculate the potential influenza contamination of facemasks from aerosol sources in various exposure scenarios. The aerosol model was validated with data from previous laboratory studies using facemasks mounted on headforms in a simulated healthcare room. The model was then used to estimate facemask contamination levels in three scenarios generated with input parameters from the literature. A second model estimated facemask contamination from a cough. It was determined that contamination levels from a single cough ( approximately 19 viruses) were much less than likely levels from aerosols (4,473 viruses on FFRs and 3,476 viruses on SMs). For aerosol contamination, a range of input values from the literature resulted in wide variation in estimated facemask contamination levels (13-202,549 viruses), depending on the values selected. Overall, these models and estimates for facemask contamination levels can be used to inform infection control practice and research related to the development of better facemasks, to characterize airborne contamination levels, and to assist in assessment of risk from reaerosolization and fomite transfer because of handling and reuse of contaminated facemasks. JF - Risk Analysis AU - Fisher, Edward M AU - Noti, John D AU - Lindsley, William G AU - Blachere, Francoise M AU - Shaffer, Ronald E AD - National Personal Protective Technology Laboratory, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Pittsburgh, PA, USA. Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 1423 EP - 1434 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 34 IS - 8 SN - 0272-4332, 0272-4332 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Risk Abstracts KW - Risk assessment KW - Contamination KW - Viruses KW - Intervention KW - Infection KW - Medical personnel KW - Disease transmission KW - Influenza KW - Surgery KW - Occupational exposure KW - Risk analysis KW - Aerosols KW - Data processing KW - Mathematical models KW - Cough KW - Pathogens KW - Protective equipment KW - Fomites KW - Health care KW - Respirators KW - V 22300:Methods KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1566829428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+Analysis&rft.atitle=Validation+and+Application+of+Models+to+Predict+Facemask+Influenza+Contamination+in+Healthcare+Settings&rft.au=Fisher%2C+Edward+M%3BNoti%2C+John+D%3BLindsley%2C+William+G%3BBlachere%2C+Francoise+M%3BShaffer%2C+Ronald+E&rft.aulast=Fisher&rft.aufirst=Edward&rft.date=2014-08-01&rft.volume=34&rft.issue=8&rft.spage=1423&rft.isbn=&rft.btitle=&rft.title=Risk+Analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Frisa.12185 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2015-04-09 N1 - SubjectsTermNotLitGenreText - Risk assessment; Aerosols; Mathematical models; Data processing; Contamination; Cough; Pathogens; Infection; Medical personnel; Fomites; Disease transmission; Influenza; Respirators; Risk analysis; Viruses; Intervention; Protective equipment; Health care; Surgery; Occupational exposure DO - http://dx.doi.org/10.1111/risa.12185 ER - TY - JOUR T1 - Enhancing reproducibility in cancer drug screening: how do we move forward? AN - 1562660355; 25015668 AB - Large-scale pharmacogenomic high-throughput screening (HTS) studies hold great potential for generating robust genomic predictors of drug response. Two recent large-scale HTS studies have reported results of such screens, revealing several known and novel drug sensitivities and biomarkers. Subsequent evaluation, however, found only moderate interlaboratory concordance in the drug response phenotypes, possibly due to differences in the experimental protocols used in the two studies. This highlights the need for community-wide implementation of standardized assays for measuring drug response phenotypes so that the full potential of HTS is realized. We suggest that the path forward is to establish best practices and standardization of the critical steps in these assays through a collective effort to ensure that the data produced from large-scale screens would not only be of high intrastudy consistency, so that they could be replicated and compared successfully across multiple laboratories. ©2014 American Association for Cancer Research. JF - Cancer research AU - Hatzis, Christos AU - Bedard, Philippe L AU - Birkbak, Nicolai J AU - Beck, Andrew H AU - Aerts, Hugo J W L AU - Stem, David F AU - Stern, David F AU - Shi, Leming AU - Clarke, Robert AU - Quackenbush, John AU - Haibe-Kains, Benjamin AD - Section of Medical Oncology, Yale University School of Medicine; Yale Cancer Center, Yale University, New Haven, Connecticut; ; Princess Margaret Cancer Centre, University Health Network; Faculty of Medicine; ; Department of Systems Biology, Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark; ; Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School; ; Department of Biostatistics and Computational Biology and Center for Cancer Computational Biology; Department of Radiation Oncology and Radiology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; ; Department of Pathology, Yale University School of Medicine; Yale Cancer Center, Yale University, New Haven, Connecticut; ; National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas; State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Schools of Life Sciences and Pharmacy, Fudan University, Shanghai; and Zhanjiang Center for Translational Medicine, Shanghai, China. ; Georgetown University Medical Center, Washington, DC; ; Department of Biostatistics and Computational Biology and Center for Cancer Computational Biology; Department of Cancer Biology, Dana-Farber Cancer Institute; ; Princess Margaret Cancer Centre, University Health Network; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; bhaibeka@uhnresearch.ca. Y1 - 2014/08/01/ PY - 2014 DA - 2014 Aug 01 SP - 4016 EP - 4023 VL - 74 IS - 15 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Pharmacogenetics -- standards KW - Reproducibility of Results KW - Humans KW - High-Throughput Screening Assays -- standards KW - High-Throughput Screening Assays -- methods KW - Pharmacogenetics -- methods KW - Drug Screening Assays, Antitumor -- standards KW - Drug Screening Assays, Antitumor -- methods KW - Antineoplastic Agents -- pharmacology KW - Drug Discovery -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1562660355?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Enhancing+reproducibility+in+cancer+drug+screening%3A+how+do+we+move+forward%3F&rft.au=Hatzis%2C+Christos%3BBedard%2C+Philippe+L%3BBirkbak%2C+Nicolai+J%3BBeck%2C+Andrew+H%3BAerts%2C+Hugo+J+W+L%3BStem%2C+David+F%3BStern%2C+David+F%3BShi%2C+Leming%3BClarke%2C+Robert%3BQuackenbush%2C+John%3BHaibe-Kains%2C+Benjamin&rft.aulast=Hatzis&rft.aufirst=Christos&rft.date=2014-08-01&rft.volume=74&rft.issue=15&rft.spage=4016&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-14-0725 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-12 N1 - Date created - 2014-08-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Science. 2000 Mar 17;287(5460):1960-4 [10720314] J Natl Cancer Inst. 2012 Feb 22;104(4):311-25 [22262870] Curr Opin Biotechnol. 2001 Feb;12(1):70-4 [11167076] Genome Biol. 2001;2(8):RESEARCH0032 [11532216] Nat Genet. 2001 Dec;29(4):365-71 [11726920] Science. 2002 Oct 18;298(5593):539 [12387284] Bioinformatics. 2003 Jan 22;19(2):185-93 [12538238] Nat Rev Drug Discov. 2003 Apr;2(4):259-66 [12669025] Nature. 2012 Mar 29;483(7391):570-5 [22460902] Nature. 2012 Mar 29;483(7391):603-7 [22460905] Breast Cancer Res Treat. 2012 Aug;135(1):301-6 [22752290] Cancer Discov. 2013 Jan;3(1):52-67 [23239741] PLoS Comput Biol. 2013;9(1):e1002875 [23365551] PLoS One. 2013;8(5):e62325 [23658723] PLoS One. 2013;8(5):e63583 [23691072] Nat Chem Biol. 2013 Nov;9(11):708-14 [24013279] Pac Symp Biocomput. 2014;:63-74 [24297534] Nature. 2013 Dec 19;504(7480):389-93 [24284626] Nat Methods. 2014 Jan;11(1):33-8 [24378701] Nat Rev Genet. 2004 Apr;5(4):262-75 [15131650] Mol Pharmacol. 1974 Mar;10(2):235-47 [4212316] J Immunol Methods. 1993 Mar 15;160(1):81-8 [7680699] Nat Biotechnol. 2006 Feb;24(2):167-75 [16465162] Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3153-8 [16492761] Nat Biotechnol. 2006 Sep;24(9):1151-61 [16964229] Biostatistics. 2007 Jan;8(1):118-27 [16632515] Science. 2008 Nov 7;322(5903):917 [18988846] J Biomol Screen. 2009 Jun;14(5):476-84 [19483144] Cancer J. 2009 Sep-Oct;15(5):406-20 [19826361] Cancer Res. 2010 May 1;70(9):3677-86 [20406975] Nat Rev Cancer. 2010 Jul;10(7):514-23 [20535131] N Engl J Med. 2010 Aug 26;363(9):809-19 [20818844] Nat Rev Genet. 2010 Oct;11(10):733-9 [20838408] N Engl J Med. 2010 Oct 28;363(18):1693-703 [20979469] Nat Rev Drug Discov. 2011 Mar;10(3):188-95 [21358738] Erratum In: Cancer Res. 2014 Sep 15;74(18):5348 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/0008-5472.CAN-14-0725 ER - TY - JOUR T1 - Strong inhibition of fimbrial 3 subunit gene transcription by a novel downstream repressive element in Bordetella pertussis AN - 1560135544; 20612439 AB - The Bvg-regulated promoters for the fimbrial subunit genes fim2and fim3of Bordetella pertussis behave differently from each other both in vivo and in vitro. In vivoPfim2is significantly stronger than Pfim3, even though predictions based on the DNAsequences of BvgA-binding motifs and core promoter elements would indicate the opposite. In vitroPfim3 demonstrated robust BvgA similar to P-dependent transcriptional activation, while none was seen with Pfim2. This apparent contradiction was investigated further. By swapping sequence elements we created a number of hybrid promoters and assayed their strength in vivo. We found that, while Pfim3 promoter elements upstream of the +1 transcriptional start site do indeed direct Bvg-activated transcription more efficiently than those of Pfim2, the overall promoter strength of Pfim3in vivo is reduced due to sequences downstream of +1 that inhibit transcription more than 250-fold. This element, the DRE (downstream repressive element), was mapped to the 15 bp immediately downstream of the Pfim3 +1. Placing the DRE in different promoter contexts indicated that its activity was not specific to fim promoters, or even to Bvg-regulated promoters. However it does appear to be specific to Bordetella species in that it did not function in Escherichia coli. JF - Molecular Microbiology AU - Chen, Qing AU - Boulanger, Alice AU - Hinton, Deborah M AU - Stibitz, Scott AD - Division of Bacterial, Parasitic, and Allergenic Products Center for Biologics Evaluation and Research. FDA Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 748 EP - 758 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 93 IS - 4 SN - 0950-382X, 0950-382X KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Promoters KW - Pertussis KW - Bordetella pertussis KW - Bordetella KW - Hybrids KW - Escherichia coli KW - Transcription KW - Transcription activation KW - J 02410:Animal Diseases KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560135544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Strong+inhibition+of+fimbrial+3+subunit+gene+transcription+by+a+novel+downstream+repressive+element+in+Bordetella+pertussis&rft.au=Chen%2C+Qing%3BBoulanger%2C+Alice%3BHinton%2C+Deborah+M%3BStibitz%2C+Scott&rft.aulast=Chen&rft.aufirst=Qing&rft.date=2014-08-01&rft.volume=93&rft.issue=4&rft.spage=748&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fmmi.12690 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Pertussis; Promoters; Hybrids; Transcription; Transcription activation; Bordetella pertussis; Bordetella; Escherichia coli DO - http://dx.doi.org/10.1111/mmi.12690 ER - TY - JOUR T1 - Eight More Ways To Deal with Antibiotic Resistance AN - 1560115332; 20602520 AB - The fight against antibiotic resistance must be strengthened. We propose actions that U.S. government agencies and private sector entities can take to build a more comprehensive effort. These actions can increase the viability of investing in new antibiotics, ensure the quality and stewardship of all antibiotics, and make responses to emerging resistance more informed. Success requires the thoughtful exercise of federal authority and a firm commitment to share data and reward developers for the value generated with new, life-saving antibiotics. JF - Antimicrobial Agents & Chemotherapy AU - Metz, Matthew AU - Shlaes, David M AD - U.S. Department of Health and Human Services, Biomedical Advanced Research and Development Authority, Broad Spectrum Antimicrobials Program, Washington, DC, USA, matt.metz@pioneer.com. Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 4253 EP - 4256 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 58 IS - 8 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Data processing KW - Reinforcement KW - Antibiotics KW - Antibiotic resistance KW - Physical training KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560115332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Eight+More+Ways+To+Deal+with+Antibiotic+Resistance&rft.au=Metz%2C+Matthew%3BShlaes%2C+David+M&rft.aulast=Metz&rft.aufirst=Matthew&rft.date=2014-08-01&rft.volume=58&rft.issue=8&rft.spage=4253&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/10.1128%2FAAC.02623-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 26 N1 - Last updated - 2014-09-05 N1 - SubjectsTermNotLitGenreText - Data processing; Reinforcement; Antibiotics; Antibiotic resistance; Physical training DO - http://dx.doi.org/10.1128/AAC.02623-14 ER - TY - JOUR T1 - Genetic Diversity and Virulence Potential of Shiga Toxin-Producing Escherichia coli O113:H21 Strains Isolated from Clinical, Environmental, and Food Sources AN - 1560115091; 20602650 AB - Shiga toxin-producing Escherichia coli strains of serotype O113:H21 have caused severe human diseases, but they are unusual in that they do not produce adherence factors coded by the locus of enterocyte effacement. Here, a PCR microarray was used to characterize 65 O113:H21 strains isolated from the environment, food, and clinical infections from various countries. In comparison to the pathogenic strains that were implicated in hemolytic-uremic syndrome in Australia, there were no clear differences between the pathogens and the environmental strains with respect to the 41 genetic markers tested. Furthermore, all of the strains carried only Shiga toxin subtypes associated with human infections, suggesting that the environmental strains have the potential to cause disease. Most of the O113:H21 strains were closely related and belonged in the same clonal group (ST-223), but CRISPR analysis showed a great degree of genetic diversity among the O113:H21 strains. JF - Applied and Environmental Microbiology AU - Feng, Peter CH AU - Delannoy, Sabine AU - Lacher, David W AU - dos Santos, Luis Fernando AU - Beutin, Lothar AU - Fach, Patrick AU - Rivas, Marta AU - Hartland, Elizabeth L AU - Paton, Adrienne W AU - Guth, Beatriz EC AD - Division of Microbiology, Food and Drug Administration, College Park, Maryland, USA, peter.feng@fda.hhs.gov. Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 4757 EP - 4763 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 15 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Virulence KW - Serotypes KW - Food sources KW - Genetic markers KW - Escherichia coli KW - Genetic diversity KW - Polymerase chain reaction KW - Pathogens KW - Infection KW - Enterocytes KW - Shiga toxin KW - J 02310:Genetics & Taxonomy KW - A 01450:Environmental Pollution & Waste Treatment KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560115091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Genetic+Diversity+and+Virulence+Potential+of+Shiga+Toxin-Producing+Escherichia+coli+O113%3AH21+Strains+Isolated+from+Clinical%2C+Environmental%2C+and+Food+Sources&rft.au=Feng%2C+Peter+CH%3BDelannoy%2C+Sabine%3BLacher%2C+David+W%3Bdos+Santos%2C+Luis+Fernando%3BBeutin%2C+Lothar%3BFach%2C+Patrick%3BRivas%2C+Marta%3BHartland%2C+Elizabeth+L%3BPaton%2C+Adrienne+W%3BGuth%2C+Beatriz+EC&rft.aulast=Feng&rft.aufirst=Peter&rft.date=2014-08-01&rft.volume=80&rft.issue=15&rft.spage=4757&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01182-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 40 N1 - Last updated - 2014-11-12 N1 - SubjectsTermNotLitGenreText - Virulence; Serotypes; Food sources; Genetic markers; Polymerase chain reaction; Genetic diversity; Pathogens; Infection; Shiga toxin; Enterocytes; Escherichia coli DO - http://dx.doi.org/10.1128/AEM.01182-14 ER - TY - JOUR T1 - Retirement of Hugh A. Tilson AN - 1560113185; 20594452 JF - Environmental Health Perspectives AU - Birnbaum, Linda S AU - Woychik, Rick AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2014/08/01/ PY - 2014 DA - 2014 Aug 01 SP - A202 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 122 IS - 8 SN - 0091-6765, 0091-6765 KW - Environment Abstracts; Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560113185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Retirement+of+Hugh+A.+Tilson&rft.au=Birnbaum%2C+Linda+S%3BWoychik%2C+Rick&rft.aulast=Birnbaum&rft.aufirst=Linda&rft.date=2014-08-01&rft.volume=122&rft.issue=8&rft.spage=A202&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1408939 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-09-05 DO - http://dx.doi.org/10.1289/ehp.1408939 ER - TY - JOUR T1 - Flight Attendant Radiation Dose from Solar Particle Events AN - 1560106981; 20588630 AB - Introduction: Research has suggested that work as a flight attendant may be related to increased risk for reproductive health effects. Air cabin exposures that may influence reproductive health include radiation dose from galactic cosmic radiation and solar particle events. This paper describes the assessment of radiation dose accrued during solar particle events as part of a reproductive health study of flight attendants. Methods: Solar storm data were obtained from the National Oceanic and Atmospheric Administration Space Weather Prediction Center list of solar proton events affecting the Earth environment to ascertain storms relevant to the two study periods (1992-1996 and 1999-2001). Radiation dose from exposure to solar energetic particles was estimated using the NAIRAS model in conjunction with galactic cosmic radiation dose calculated using the CARI-6P computer program. Results: Seven solar particle events were determined to have potential for significant radiation exposure, two in the first study period and five in the second study period, and over-lapped with 24,807 flight segments. Absorbed (and effective) flight segment doses averaged 6.5 mu Gy (18 mu Sv) and 3.1 mu Gy (8.3 mu Sv) for the first and second study periods, respectively. Maximum doses were as high as 440 mu Gy (1.2 mSv) and 20 flight segments had doses greater than 190 mu Gy (0.5 mSv). Discussion: During solar particle events, a pregnant flight attendant could potentially exceed the equivalent dose limit to the conceptus of 0.5 mSv in a month recommended by the National Council on Radiation Protection and Measurements. JF - Aviation, Space, and Environmental Medicine AU - Anderson, Jeri L AU - Mertens, Christopher J AU - Grajewski, Barbara AU - Luo, Lian AU - Tseng, Chih-yu AU - Cassinelli, Rick T, II AD - Langley Research Center, National Aeronautics and Space Administration, Hampton, VA; National Institute for Occupational Safety and Health, 4676 Columbia Pkwy, MS R-14, Cincinnati, OH 45226, JLAnderson@cdc.gov Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 828 EP - 832 PB - Aerospace Medical Association, 320 S. Henry St. Alexandria VA 22314-3579 United States VL - 85 IS - 8 SN - 0095-6562, 0095-6562 KW - Health & Safety Science Abstracts; Risk Abstracts KW - absorbed dose KW - effective dose KW - conceptus KW - reproductive health KW - Prediction KW - Risk assessment KW - Weather KW - Computer programs KW - Radiation KW - Cosmic radiation KW - Reproduction KW - Particulates KW - Storms KW - Councils KW - Pregnancy KW - R2 23020:Technological risks KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560106981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aviation%2C+Space%2C+and+Environmental+Medicine&rft.atitle=Flight+Attendant+Radiation+Dose+from+Solar+Particle+Events&rft.au=Anderson%2C+Jeri+L%3BMertens%2C+Christopher+J%3BGrajewski%2C+Barbara%3BLuo%2C+Lian%3BTseng%2C+Chih-yu%3BCassinelli%2C+Rick+T%2C+II&rft.aulast=Anderson&rft.aufirst=Jeri&rft.date=2014-08-01&rft.volume=85&rft.issue=8&rft.spage=828&rft.isbn=&rft.btitle=&rft.title=Aviation%2C+Space%2C+and+Environmental+Medicine&rft.issn=00956562&rft_id=info:doi/10.3357%2FASEM.3989.2014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 22 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Risk assessment; Prediction; Computer programs; Weather; Radiation; Cosmic radiation; Reproduction; Particulates; Councils; Storms; Pregnancy DO - http://dx.doi.org/10.3357/ASEM.3989.2014 ER - TY - JOUR T1 - Novel Microarray Design for Molecular Serotyping of Shiga Toxin-Producing Escherichia coli Strains Isolated from Fresh Produce AN - 1560106909; 20602645 AB - Serotyping Escherichia coli is a cumbersome and complex procedure due to the existence of large numbers of O- and H-antigen types. It can also be unreliable, as many Shiga toxin-producing E. coli (STEC) strains isolated from fresh produce cannot be typed by serology or have only partial serotypes. The FDA E. coli identification (FDA-ECID) microarray, designed for characterizing pathogenic E. coli, contains a molecular serotyping component, which was evaluated here for its efficacy. Analysis of a panel of 75 reference E. coli strains showed that the array correctly identified the O and H types in 97% and 98% of the strains, respectively. Comparative analysis of 73 produce STEC strains showed that serology and the array identified 37% and 50% of the O types, respectively, and that the array was able to identify 16 strains that could not be O serotyped. Furthermore, the array identified the H types of 97% of the produce STEC strains compared to 65% by serology, including six strains that were mistyped by serology. These results show that the array is an effective alternative to serology in serotyping environmental E. coli isolates. JF - Applied and Environmental Microbiology AU - Lacher, David W AU - Gangiredla, Jayanthi AU - Jackson, Scott A AU - Elkins, Christopher A AU - Feng, Peter CH AD - Division of Molecular Biology, U.S. FDA, Laurel, Maryland, USA, chris.elkins@fda.hhs.gov. Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 4677 EP - 4682 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 15 SN - 0099-2240, 0099-2240 KW - Biotechnology and Bioengineering Abstracts; Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Serotypes KW - Escherichia coli KW - Serotyping KW - Serology KW - A 01450:Environmental Pollution & Waste Treatment KW - W 30900:Methods KW - X 24300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560106909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Novel+Microarray+Design+for+Molecular+Serotyping+of+Shiga+Toxin-Producing+Escherichia+coli+Strains+Isolated+from+Fresh+Produce&rft.au=Lacher%2C+David+W%3BGangiredla%2C+Jayanthi%3BJackson%2C+Scott+A%3BElkins%2C+Christopher+A%3BFeng%2C+Peter+CH&rft.aulast=Lacher&rft.aufirst=David&rft.date=2014-08-01&rft.volume=80&rft.issue=15&rft.spage=4677&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.01049-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Number of references - 24 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Serotypes; Serotyping; Serology; Escherichia coli DO - http://dx.doi.org/10.1128/AEM.01049-14 ER - TY - RPRT T1 - Table of contents AN - 1557089600 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 4 EP - 5 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1557089600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=Table+of+contents&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-08-01&rft.volume=&rft.issue=580&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2014 N1 - Last updated - 2015-03-21 ER - TY - RPRT T1 - FOREWORD AN - 1557089493 JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 1 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1557089493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=FOREWORD&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-08-01&rft.volume=&rft.issue=580&rft.spage=0_2&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2014 N1 - Last updated - 2015-03-21 ER - TY - RPRT T1 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF [Beta]-PICOLINE (CAS No. 108-99-6) IN F344/N RATS AND B6C3F1/N MICE (DRINKING WATER STUDIES) AN - 1557089418 AB - β-Picoline is used as a solvent in making pharmaceuticals, insecticides, resins, and dyes. It is related in structure to pyridine, which causes cancer in laboratory animals. We studied the effects of β-picoline in drinking water on male and female rats and mice to identify potential toxic or cancer-related hazards. We gave drinking water containing 156.25, 312.5, or 625 mg of β-picoline per liter of water to groups of 50 male and female rats for 2 years. Similar groups of male and female mice were given 312.5, 625, or 1,250 mg of β-picoline per liter of water. Control animals received the same tap water with no chemical added. At the end of the study tissues from more than 40 sites were examined for every animal. Female rats and female mice exposed to β-picoline had increased rates of lung tumors, and male mice also had slightly increased rates of lung tumors. Female mice receiving β-picoline also had increased rates of malignant tumors of the liver (carcinoma and hepatoblastoma). We conclude that β-picoline in the drinking water caused lung cancer in female rats and female mice and liver cancer in female mice. Lung tumors in male mice may have been related to β-picoline exposure. JF - Technical Report Series. National Toxicology Program AU - Anonymous Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 1 EP - 13,15-17,19-27,29-59,61-63,65-93,95-137,139-141,143-147,149-163,165-171 CY - Research Triangle Park PB - U.S. Public Health Service, National Toxicology Program KW - Environmental Studies KW - Solvents KW - Drinking water KW - Rodents KW - Toxicity KW - Carcinogens KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1557089418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Technical+Report+Series.+National+Toxicology+Program&rft.atitle=NTP+TECHNICAL+REPORT+ON+THE+TOXICOLOGY+AND+CARCINOGENESIS+STUDIES+OF+%5BBeta%5D-PICOLINE+%28CAS+No.+108-99-6%29+IN+F344%2FN+RATS+AND+B6C3F1%2FN+MICE+%28DRINKING+WATER+STUDIES%29&rft.au=Anonymous&rft.aulast=Anonymous&rft.aufirst=&rft.date=2014-08-01&rft.volume=&rft.issue=580&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Technical+Report+Series.+National+Toxicology+Program&rft.issn=08888051&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Public Health Service, National Toxicology Program Aug 2014 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2015-03-21 ER - TY - JOUR T1 - Mortality among a cohort of U.S. commercial airline cockpit crew AN - 1554949209; 20446182 AB - Background We evaluated mortality among 5,964 former U.S. commercial cockpit crew (pilots and flight engineers). The outcomes of a priori interest were non-chronic lymphocytic leukemia, central nervous system (CNS) cancer (including brain), and malignant melanoma. Methods Vital status was ascertained through 2008. Life table and Cox regression analyses were conducted. Cumulative exposure to cosmic radiation was estimated from work history data. Results Compared to the U.S. general population, mortality from all causes, all cancer, and cardiovascular diseases was decreased, but mortality from aircraft accidents was highly elevated. Mortality was elevated for malignant melanoma but not for non-chronic lymphocytic leukemia. CNS cancer mortality increased with an increase in cumulative radiation dose. Conclusions Cockpit crew had a low all-cause, all-cancer, and cardiovascular disease mortality but elevated aircraft accident mortality. Further studies are needed to clarify the risk of CNS and other radiation-associated cancers in relation to cosmic radiation and other workplace exposures. Am. J. Ind. Med. 57:906-914, 2014. copyright 2014 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Yong, Lee C AU - Pinkerton, Lynne E AU - Yiin, James H AU - Anderson, Jeri L AU - Deddens, James A AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, Cincinnati, Ohio. Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 906 EP - 914 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 8 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Central nervous system KW - Mortality KW - Occupational safety KW - Crew safety KW - Cancer KW - Melanoma KW - Leukemia KW - Health risks KW - Accidents KW - Aircraft KW - Cosmic radiation KW - Airlines KW - Cardiovascular diseases KW - Occupational exposure KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1554949209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Mortality+among+a+cohort+of+U.S.+commercial+airline+cockpit+crew&rft.au=Yong%2C+Lee+C%3BPinkerton%2C+Lynne+E%3BYiin%2C+James+H%3BAnderson%2C+Jeri+L%3BDeddens%2C+James+A&rft.aulast=Yong&rft.aufirst=Lee&rft.date=2014-08-01&rft.volume=57&rft.issue=8&rft.spage=906&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22318 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-08-01 N1 - Last updated - 2014-09-05 N1 - SubjectsTermNotLitGenreText - Mortality; Central nervous system; Occupational safety; Crew safety; Cancer; Melanoma; Health risks; Leukemia; Accidents; Aircraft; Cosmic radiation; Airlines; Cardiovascular diseases; Occupational exposure DO - http://dx.doi.org/10.1002/ajim.22318 ER - TY - JOUR T1 - Sensitivity analysis in non-inferiority trials with residual inconstancy after covariate adjustment AN - 1554208024; 4589293 AB - A major issue in non-inferiority trials is the controversial assumption of constancy, namely that the active control has the same effect relative to placebo as in previous studies comparing the active control with placebo. The constancy assumption is often in doubt, which has motivated various methods that ‘ ;discount' the control effect estimate from historical data as well as methods that adjust for imbalances in observed covariates. We develop a new approach to deal with residual inconstancy, i.e. possible violations of the constancy assumption due to imbalances in unmeasured covariates after adjusting for the measured covariates. We characterize the extent of residual inconstancy under a generalized linear model framework and use the results to obtain fully adjusted estimates of the control effect in the current study based on plausible assumptions about an unmeasured covariate. Because such assumptions may be difficult to justify, we propose a sensitivity analysis approach that covers a range of situations. This approach is developed for indirect comparison with placebo and effect retention, and implemented through additive and multiplicative adjustments. The approach proposed is applied to two examples concerning benign prostate hyperplasia and human immunodeficiency virus infection, and evaluated in simulation studies. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Soon, Guoxing AU - Zhang, Bo AU - Zhang, Zhiwei AU - Nie, Lei AD - US Food and Drug Administration ; Oregon State University Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 515 EP - 538 VL - 63 IS - 4 SN - 0035-9254, 0035-9254 KW - Economics KW - Generalization KW - Simulation KW - Linear models KW - Estimation KW - Covariance KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1554208024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Sensitivity+analysis+in+non-inferiority+trials+with+residual+inconstancy+after+covariate+adjustment&rft.au=Soon%2C+Guoxing%3BZhang%2C+Bo%3BZhang%2C+Zhiwei%3BNie%2C+Lei&rft.aulast=Soon&rft.aufirst=Guoxing&rft.date=2014-08-01&rft.volume=63&rft.issue=4&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/10.1111%2Frssc.12050 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-08-18 N1 - Last updated - 2014-08-19 N1 - SubjectsTermNotLitGenreText - 2977 13249 10214 12224 971; 5443; 7419 8163; 4403 7854; 11670; 7994 DO - http://dx.doi.org/10.1111/rssc.12050 ER - TY - JOUR T1 - Infant toxicology: state of the science and considerations in evaluation of safety. AN - 1553703108; 24824476 AB - Differences in the physiology and biological susceptibilities of adults and infants have led to growing interest in safety evaluation methods for exposures from infant formula packaging. In addition to potential physiological differences, infants aged 0-6 months may consume a sole source of food, infant formula or breast milk, and consume higher amounts of food relative to body weight compared to adults. While the duration of the exposure is short compared to the expected lifespan of the individual, it occurs during a period of important developmental processes. The purpose of this document is to (1) review key biological and exposure elements that may impact the evaluation of safety for food contact products intended for use by infants, (2) summarize the current reproductive and developmental toxicity testing protocols available, and (3) identify potential data gaps concerning this period of development. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Neal-Kluever, April AU - Aungst, Jason AU - Gu, Yan AU - Hatwell, Karen AU - Muldoon-Jacobs, Kristi AU - Liem, Ayesha AU - Ogungbesan, Adejoke AU - Shackelford, Mary AD - United States Food and Drug Administration, Center For Food Safety and Applied Nutrition, Office of Food Additive Safety, Division of Food Contact Notifications, United States. Electronic address: april.kluever@fda.hhs.gov. ; United States Food and Drug Administration, Center For Food Safety and Applied Nutrition, Office of Food Additive Safety, Division of Food Contact Notifications, United States. ; Oak Ridge Institute for Science and Education (ORISE), United States. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 68 EP - 83 VL - 70 KW - Index Medicus KW - Developmental toxicology KW - Toxicology KW - Safety assessment KW - Infants KW - Immune System -- growth & development KW - Endocrine System -- growth & development KW - Endpoint Determination KW - Reproducibility of Results KW - Reproduction -- drug effects KW - Humans KW - Toxicokinetics KW - Nervous System -- drug effects KW - Risk Assessment KW - Infant KW - Immune System -- drug effects KW - Postnatal Care KW - Endocrine System -- drug effects KW - Nervous System -- growth & development KW - Diet KW - Child Development KW - Toxicity Tests -- methods KW - Infant Food -- analysis KW - Food Packaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1553703108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Infant+toxicology%3A+state+of+the+science+and+considerations+in+evaluation+of+safety.&rft.au=Neal-Kluever%2C+April%3BAungst%2C+Jason%3BGu%2C+Yan%3BHatwell%2C+Karen%3BMuldoon-Jacobs%2C+Kristi%3BLiem%2C+Ayesha%3BOgungbesan%2C+Adejoke%3BShackelford%2C+Mary&rft.aulast=Neal-Kluever&rft.aufirst=April&rft.date=2014-08-01&rft.volume=70&rft.issue=&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2014.05.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-03-03 N1 - Date created - 2014-07-04 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2014.05.003 ER - TY - JOUR T1 - A survey of liquid chromatographic-mass spectrometric analysis of mercapturic acid biomarkers in occupational and environmental exposure monitoring. AN - 1552377296; 24746702 AB - High-performance liquid chromatography/mass spectrometry (HPLC/MS) is sensitive and specific for targeted quantitative analysis and is readily utilized for small molecules from biological matrices. This brief review describes recent selected HPLC/MS methods for the determination of urinary mercapturic acids (mercapturates) which are useful as biomarkers in characterizing human exposure to electrophilic industrial chemicals in occupational and environmental studies. Electrophilic compounds owing to their reactivity are used in chemical and industrial processes. They are present in industrial emissions, are combustion products of fossil fuels, and are components in tobacco smoke. Their presence in both the industrial and general environments are of concern for human and environmental health. Urinary mercapturates which are the products of metabolic detoxification of reactive chemicals provide a non-invasive tool to investigate human exposure to electrophilic toxicants. Selected recent mercapturate quantification methods are summarized and specific cases are presented. The biological formation of mercapturates is introduced and their use as biomarkers of metabolic processing of electrophilic compounds is discussed. Also, the use of liquid chromatography/tandem mass spectrometry in simultaneous determinations of the mercapturates of multiple parent compounds in a single determination is considered, as well as future trends and limitations in this area of research. Published by Elsevier B.V. JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences AU - Mathias, Patricia I AU - B'Hymer, Clayton AD - U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Science and Technology, Biomonitoring and Health Assessment Branch, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, United States. Electronic address: pmathias@cdc.gov. ; U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Science and Technology, Biomonitoring and Health Assessment Branch, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, United States. Y1 - 2014/08/01/ PY - 2014 DA - 2014 Aug 01 SP - 136 EP - 145 VL - 964 KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Liquid chromatography KW - Urinary biomarker KW - Mercapturic acid KW - Mass spectrometry KW - Industrial chemicals KW - Occupational exposure KW - Animals KW - Humans KW - Acetylcysteine -- urine KW - Chromatography, Liquid -- methods KW - Environmental Exposure -- analysis KW - Acetylcysteine -- analysis KW - Mass Spectrometry -- methods KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552377296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.atitle=A+survey+of+liquid+chromatographic-mass+spectrometric+analysis+of+mercapturic+acid+biomarkers+in+occupational+and+environmental+exposure+monitoring.&rft.au=Mathias%2C+Patricia+I%3BB%27Hymer%2C+Clayton&rft.aulast=Mathias&rft.aufirst=Patricia&rft.date=2014-08-01&rft.volume=964&rft.issue=&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Journal+of+chromatography.+B%2C+Analytical+technologies+in+the+biomedical+and+life+sciences&rft.issn=1873-376X&rft_id=info:doi/10.1016%2Fj.jchromb.2014.02.057 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-09 N1 - Date created - 2014-06-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Biochem J. 1966 Jul;100(1):282-8 [5965256] Rapid Commun Mass Spectrom. 2004;18(17):1983-8 [15329865] Chem Res Toxicol. 2007 Jul;20(7):986-90 [17559234] Toxicol Sci. 2007 Aug;98(2):427-35 [17517825] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Feb 15;863(1):115-22 [18255357] J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Mar 1;863(2):283-92 [18258494] Anal Bioanal Chem. 2008 Jul;391(5):1931-9 [18454284] Rapid Commun Mass Spectrom. 2008 Sep;22(17):2629-38 [18666198] J Agric Food Chem. 2008 Nov 12;56(21):9828-34 [18841985] Anal Bioanal Chem. 2009 Feb;393(3):969-81 [19018522] J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 15;877(8-9):827-32 [19237326] J Chromatogr B Analyt Technol Biomed Life Sci. 2009 May 1;877(13):1388-93 [19233748] Chem Res Toxicol. 2009 Jun;22(6):1018-25 [19522547] Int Arch Occup Environ Health. 2010 Mar;83(3):341-56 [19830448] J Chromatogr Sci. 2010 Mar;48(3):194-9 [20223085] J Sep Sci. 2010 Mar;33(6-7):681-97 [20155745] Anal Bioanal Chem. 2010 Aug;397(8):3563-74 [20556363] J Occup Environ Med. 2010 Aug;52(8):769-77 [20657306] J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 1;878(27):2506-14 [19766066] J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 1;878(27):2520-8 [20227354] J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Oct 1;878(27):2515-9 [20462811] Chem Res Toxicol. 2011 Sep 19;24(9):1516-26 [21749114] J Sep Sci. 2011 Dec;34(24):3606-18 [22162441] Anal Bioanal Chem. 2012 Feb;402(6):2113-20 [22231508] J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Jul 15;901:1-8 [22721710] Chem Res Toxicol. 2012 Aug 20;25(8):1565-7 [22817647] Toxicol Mech Methods. 2012 Sep;22(7):526-32 [22519856] Talanta. 2012 Aug 30;98:211-9 [22939149] Anal Biochem. 2012 Nov 1;430(1):75-82 [22868354] Anal Chim Acta. 2012 Oct 31;750:152-60 [23062436] Crit Rev Toxicol. 2013 Feb;43(2):119-53 [23346981] J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Dec 5;781(1-2):269-90 [12450663] Crit Rev Toxicol. 1992;22(5-6):271-306 [1489508] J Pharm Biomed Anal. 2005 Feb 7;37(1):165-70 [15664757] J Mass Spectrom. 2005 Apr;40(4):511-5 [15712353] J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 18;830(2):185-95 [16297668] Biomed Chromatogr. 2006 Jun-Jul;20(6-7):597-604 [16779771] Toxicol Appl Pharmacol. 2006 Aug 15;215(1):23-36 [16513153] J Sep Sci. 2006 Aug;29(12):1784-821 [16970185] J Chromatogr A. 2006 Oct 27;1131(1-2):58-66 [16884730] J Chromatogr B Biomed Sci Appl. 2001 Jan 5;750(1):163-9 [11204217] Xenobiotica. 2013 Aug;43(8):651-60 [23278281] Rapid Commun Mass Spectrom. 2003;17(2):163-70 [12512096] J Agric Food Chem. 2003 Jul 30;51(16):4504-26 [14705871] J Chromatogr B Analyt Technol Biomed Life Sci. 2004 Apr 5;802(2):361-6 [15018799] Rapid Commun Mass Spectrom. 2004;18(16):1865-8 [15329881] Xenobiotica. 1979 Dec;9(12):763-72 [532220] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jchromb.2014.02.057 ER - TY - JOUR T1 - Genome-wide interaction study of smoking and bladder cancer risk. AN - 1552370757; 24662972 AB - Bladder cancer is a complex disease with known environmental and genetic risk factors. We performed a genome-wide interaction study (GWAS) of smoking and bladder cancer risk based on primary scan data from 3002 cases and 4411 controls from the National Cancer Institute Bladder Cancer GWAS. Alternative methods were used to evaluate both additive and multiplicative interactions between individual single nucleotide polymorphisms (SNPs) and smoking exposure. SNPs with interaction P values < 5 × 10(-) (5) were evaluated further in an independent dataset of 2422 bladder cancer cases and 5751 controls. We identified 10 SNPs that showed association in a consistent manner with the initial dataset and in the combined dataset, providing evidence of interaction with tobacco use. Further, two of these novel SNPs showed strong evidence of association with bladder cancer in tobacco use subgroups that approached genome-wide significance. Specifically, rs1711973 (FOXF2) on 6p25.3 was a susceptibility SNP for never smokers [combined odds ratio (OR) = 1.34, 95% confidence interval (CI) = 1.20-1.50, P value = 5.18 × 10(-) (7)]; and rs12216499 (RSPH3-TAGAP-EZR) on 6q25.3 was a susceptibility SNP for ever smokers (combined OR = 0.75, 95% CI = 0.67-0.84, P value = 6.35 × 10(-) (7)). In our analysis of smoking and bladder cancer, the tests for multiplicative interaction seemed to more commonly identify susceptibility loci with associations in never smokers, whereas the additive interaction analysis identified more loci with associations among smokers-including the known smoking and NAT2 acetylation interaction. Our findings provide additional evidence of gene-environment interactions for tobacco and bladder cancer. Published by Oxford University Press 2014. JF - Carcinogenesis AU - Figueroa, Jonine D AU - Han, Summer S AU - Garcia-Closas, Montserrat AU - Baris, Dalsu AU - Jacobs, Eric J AU - Kogevinas, Manolis AU - Schwenn, Molly AU - Malats, Nuria AU - Johnson, Alison AU - Purdue, Mark P AU - Caporaso, Neil AU - Landi, Maria Teresa AU - Prokunina-Olsson, Ludmila AU - Wang, Zhaoming AU - Hutchinson, Amy AU - Burdette, Laurie AU - Wheeler, William AU - Vineis, Paolo AU - Siddiq, Afshan AU - Cortessis, Victoria K AU - Kooperberg, Charles AU - Cussenot, Olivier AU - Benhamou, Simone AU - Prescott, Jennifer AU - Porru, Stefano AU - Bueno-de-Mesquita, H Bas AU - Trichopoulos, Dimitrios AU - Ljungberg, Börje AU - Clavel-Chapelon, Françoise AU - Weiderpass, Elisabete AU - Krogh, Vittorio AU - Dorronsoro, Miren AU - Travis, Ruth AU - Tjønneland, Anne AU - Brenan, Paul AU - Chang-Claude, Jenny AU - Riboli, Elio AU - Conti, David AU - Gago-Dominguez, Manuela AU - Stern, Mariana C AU - Pike, Malcolm C AU - Van Den Berg, David AU - Yuan, Jian-Min AU - Hohensee, Chancellor AU - Rodabough, Rebecca AU - Cancel-Tassin, Geraldine AU - Roupret, Morgan AU - Comperat, Eva AU - Chen, Constance AU - De Vivo, Immaculata AU - Giovannucci, Edward AU - Hunter, David J AU - Kraft, Peter AU - Lindstrom, Sara AU - Carta, Angela AU - Pavanello, Sofia AU - Arici, Cecilia AU - Mastrangelo, Giuseppe AU - Karagas, Margaret R AU - Schned, Alan AU - Armenti, Karla R AU - Hosain, G M Monawar AU - Haiman, Chris A AU - Fraumeni, Joseph F AU - Chanock, Stephen J AU - Chatterjee, Nilanjan AU - Rothman, Nathaniel AU - Silverman, Debra T AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, Institute for Cancer Research, London, UK, Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain, Municipal Institute of Medical Research, Barcelona, Spain, CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, National School of Public Health, Athens, Greece, Maine Cancer Registry, Augusta, ME, USA, Spanish National Cancer Research Centre (CNIO), Madrid, Spain, Vermont Cancer Registry, Burlington, VT, USA, Center for Genomics Research, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD, USA, Information Management Services, Inc., Rockville, MD, USA, Imperial College London, London, UK, Department of Preventive Medicine and Department of Obstetrics & Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA, Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA, Department of Urology, Assistance Publique-Hôpitaux de Paris, Tenon Hospital, Paris, France, Centre de Recherche sur les Pathologies Prostatiques, Paris, France, Institut national de la sante et de la recherche medicale, U946, Foundation Jean Dausset Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France, Centre National de la Receherche Scientifique, UMR8200, Institut Gustave-Roussy, Villejuif, France, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy, National Institute for Public Health and the Environment (RIVM), Biltho ; Institute for Cancer Research, London, UK. ; Epidemiology Research Program, American Cancer Society, Atlanta, GA, USA. ; Maine Cancer Registry, Augusta, ME, USA. ; Spanish National Cancer Research Centre (CNIO), Madrid, Spain. ; Vermont Cancer Registry, Burlington, VT, USA. ; Center for Genomics Research, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD, USA. ; Information Management Services, Inc., Rockville, MD, USA. ; Imperial College London, London, UK. ; Department of Preventive Medicine and Department of Obstetrics & Gynecology, Keck School of Medicine of USC, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. ; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA. ; Department of Urology, Assistance Publique-Hôpitaux de Paris, Tenon Hospital, Paris, France, Centre de Recherche sur les Pathologies Prostatiques, Paris, France. ; Institut national de la sante et de la recherche medicale, U946, Foundation Jean Dausset Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France, Centre National de la Receherche Scientifique, UMR8200, Institut Gustave-Roussy, Villejuif, France. ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. ; Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy. ; Imperial College London, London, UK, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands, Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. ; Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden. ; Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. ; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain, Public Health Division of Gipuzkoa, BioDonostia Research Institute, Health Department of Basque Region, San Sebastian, Spain. ; Cancer Epidemiology Unit, University of Oxford, Oxford, UK. ; Danish Cancer Society Research Center, Copenhagen, Denmark. ; International Agency for Research on Cancer, Lyon, France. ; DKFZ, Heidelberg, Germany. ; Genomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain. ; Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ; UPMC Univ Paris 06, GRC n°5,ONCOTYPE-URO, Paris, France. ; Department of Urology, Assistance Publique-Hôpitaux de Paris, Tenon Hospital, Paris, France, Centre de Recherche sur les Pathologies Prostatiques, Paris, France, UPMC Univ Paris 06, GRC n°5,ONCOTYPE-URO, Paris, France. ; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. ; Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA. ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Broad Institute of Harvard and MIT, Cambridge, MA, USA. ; Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA. ; Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy; ; Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. ; New Hampshire Department of Health and Human Services, Concord, NH, USA and. ; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 1737 EP - 1744 VL - 35 IS - 8 KW - Biomarkers, Tumor KW - 0 KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Prognosis KW - Case-Control Studies KW - Genetic Predisposition to Disease KW - Meta-Analysis as Topic KW - Biomarkers, Tumor -- genetics KW - Urinary Bladder Neoplasms -- etiology KW - Genome, Human KW - Smoking -- adverse effects KW - Gene-Environment Interaction KW - Polymorphism, Single Nucleotide -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1552370757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Genome-wide+interaction+study+of+smoking+and+bladder+cancer+risk.&rft.au=Figueroa%2C+Jonine+D%3BHan%2C+Summer+S%3BGarcia-Closas%2C+Montserrat%3BBaris%2C+Dalsu%3BJacobs%2C+Eric+J%3BKogevinas%2C+Manolis%3BSchwenn%2C+Molly%3BMalats%2C+Nuria%3BJohnson%2C+Alison%3BPurdue%2C+Mark+P%3BCaporaso%2C+Neil%3BLandi%2C+Maria+Teresa%3BProkunina-Olsson%2C+Ludmila%3BWang%2C+Zhaoming%3BHutchinson%2C+Amy%3BBurdette%2C+Laurie%3BWheeler%2C+William%3BVineis%2C+Paolo%3BSiddiq%2C+Afshan%3BCortessis%2C+Victoria+K%3BKooperberg%2C+Charles%3BCussenot%2C+Olivier%3BBenhamou%2C+Simone%3BPrescott%2C+Jennifer%3BPorru%2C+Stefano%3BBueno-de-Mesquita%2C+H+Bas%3BTrichopoulos%2C+Dimitrios%3BLjungberg%2C+B%C3%B6rje%3BClavel-Chapelon%2C+Fran%C3%A7oise%3BWeiderpass%2C+Elisabete%3BKrogh%2C+Vittorio%3BDorronsoro%2C+Miren%3BTravis%2C+Ruth%3BTj%C3%B8nneland%2C+Anne%3BBrenan%2C+Paul%3BChang-Claude%2C+Jenny%3BRiboli%2C+Elio%3BConti%2C+David%3BGago-Dominguez%2C+Manuela%3BStern%2C+Mariana+C%3BPike%2C+Malcolm+C%3BVan+Den+Berg%2C+David%3BYuan%2C+Jian-Min%3BHohensee%2C+Chancellor%3BRodabough%2C+Rebecca%3BCancel-Tassin%2C+Geraldine%3BRoupret%2C+Morgan%3BComperat%2C+Eva%3BChen%2C+Constance%3BDe+Vivo%2C+Immaculata%3BGiovannucci%2C+Edward%3BHunter%2C+David+J%3BKraft%2C+Peter%3BLindstrom%2C+Sara%3BCarta%2C+Angela%3BPavanello%2C+Sofia%3BArici%2C+Cecilia%3BMastrangelo%2C+Giuseppe%3BKaragas%2C+Margaret+R%3BSchned%2C+Alan%3BArmenti%2C+Karla+R%3BHosain%2C+G+M+Monawar%3BHaiman%2C+Chris+A%3BFraumeni%2C+Joseph+F%3BChanock%2C+Stephen+J%3BChatterjee%2C+Nilanjan%3BRothman%2C+Nathaniel%3BSilverman%2C+Debra+T&rft.aulast=Figueroa&rft.aufirst=Jonine&rft.date=2014-08-01&rft.volume=35&rft.issue=8&rft.spage=1737&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/10.1093%2Fcarcin%2Fbgu064 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-18 N1 - Date created - 2014-08-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2012 Jan;40(Database issue):D930-4 [22064851] Cancer Res. 2013 Apr 1;73(7):2211-20 [23536561] Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4974-9 [22416122] Hum Mol Genet. 2011 Nov 1;20(21):4282-9 [21824976] Cancer Causes Control. 2001 Jan;12(1):13-21 [11227921] Am J Epidemiol. 2001 Oct 15;154(8):687-93 [11590080] Stat Med. 1994 Jan 30;13(2):153-62 [8122051] Nature. 1996 Aug 15;382(6592):622-6 [8757131] Stat Med. 1997 Aug 15;16(15):1731-43 [9265696] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] Int J Obes (Lond). 2005 Oct;29(10):1267-74 [15997248] Hum Mol Genet. 2014 Mar 1;23(5):1387-98 [24163127] Am J Hum Genet. 2006 Mar;78(3):464-79 [16465622] Development. 2006 Mar;133(5):833-43 [16439479] Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1348-54 [16835335] Chem Res Toxicol. 2006 Oct;19(10):1366-73 [17040106] Int J Epidemiol. 2007 Feb;36(1):23-8 [17510073] Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1214-21 [18483344] Nat Genet. 2008 Nov;40(11):1307-12 [18794855] Nat Genet. 2009 Feb;41(2):221-7 [19151717] Nat Genet. 2009 Sep;41(9):991-5 [19648920] Cancer Res. 2009 Sep 1;69(17):6857-64 [19706757] J Biol Chem. 2009 Oct 23;284(43):29437-45 [19684019] J Natl Cancer Inst. 2009 Nov 18;101(22):1553-61 [19917915] Pharmacogenet Genomics. 2010 Jan;20(1):26-37 [19997042] Nat Genet. 2010 Nov;42(11):978-84 [20972438] Carcinogenesis. 2011 Feb;32(2):182-9 [21037224] Pharmacogenet Genomics. 2011 Apr;21(4):231-6 [20739907] Environ Health Perspect. 2010 Nov;118(11):1545-50 [20675267] Hum Mol Genet. 2011 Nov 1;20(21):4268-81 [21750109] Int J Cancer. 2011 Dec 15;129(12):2894-904 [21678399] Genome Res. 2012 Sep;22(9):1790-7 [22955989] Nature. 2012 Sep 6;489(7414):91-100 [22955619] Am J Epidemiol. 2012 Dec 1;176(11):1060-7 [23118105] Nat Genet. 2012 Dec;44(12):1330-5 [23143601] J Clin Endocrinol Metab. 2013 Mar;98(3):E497-502 [23408570] Hum Mol Genet. 2012 Apr 15;21(8):1918-30 [22228101] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/carcin/bgu064 ER - TY - RPRT T1 - Prevalence of Coronary Heart Disease or Stroke Among Workers Aged <55 Years - United States, 2008-2012 AN - 1551736454; 25078653 AB - Cardiovascular disease accounts for one in three deaths in the US each year, and coronary heart disease and stroke account for most of those deaths. To try to prevent 1 million heart attacks and strokes by 2017, the US Department of Health and Human Services launched the Million Hearts initiative, promoting proven and effective interventions in commmunities and clinical settings. In workplace settings, cardiovascular disease can be addressed through a Total Worker Health program, which integrates occupational safety and health protection with health pmmotion. Here, Luckhaupt and Calvert analyzed data from the National Health Interview Survey for the period 2008-2012 to identify workers likely to benefit from such program and to estimate the prevalence of a history of coronary heart disease or stroke (CHD/stroke) among adults aged <55 years by selected characteristics, employment status, occupation category and industry of employment. Results showed that 1.9% of employed adults aged <55 years reported a history of CHD/stroke, compared with 2.5% of unemployed adults looking for work, and 6.3% of adults not in the labor force. Workers employed in service and blue collar occupations were more likely than those in white collar occupations to report a history of CHD/stroke. JF - MMWR. Morbidity and Mortality Weekly Report AU - Luckhaupt, Sara E, MD AU - Calvert, Geoffrey M, MD Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 645 EP - 9 CY - Atlanta PB - U.S. Center for Disease Control KW - Public Health And Safety KW - Cardiovascular disease KW - Stroke KW - Workers KW - Wellness programs KW - Middle age KW - United States--US KW - Risk Factors KW - Humans KW - Health Surveys KW - Adult KW - Middle Aged KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Stroke -- epidemiology KW - Employment -- statistics & numerical data KW - Coronary Disease -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551736454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.atitle=Prevalence+of+Coronary+Heart+Disease+or+Stroke+Among+Workers+Aged+%26lt%3B55+Years+-+United+States%2C+2008-2012&rft.au=Luckhaupt%2C+Sara+E%2C+MD%3BCalvert%2C+Geoffrey+M%2C+MD&rft.aulast=Luckhaupt&rft.aufirst=Sara&rft.date=2014-08-01&rft.volume=63&rft.issue=30&rft.spage=645&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.issn=01492195&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Center for Disease Control Aug 2014 N1 - Document feature - Tables; References N1 - Last updated - 2014-09-17 ER - TY - RPRT T1 - Little Filtered Cigar, Cigarillo, and Premium Cigar Smoking Among Adults - United States, 2012-2013 AN - 1551736413; 25078654 AB - The burden of death and disease from tobacco use in the US has been caused overwhelmingly by cigarettes and other smoked tobacco products. While cigarette consumption in the country declined during 2000-2011, consumption of cigars more than doubled during the same period. The cigar market includes diverse product types manufactured with a variety of shapes and sizes, filters, tips, flavors, and prices. Although national estimates of cigar consumption have been reported previously, data characterizing who smokes different cigar types are limited. A recent analysis from the 2012-2013 National Adult Tobacco Survey (NATS) found that more than one in 20 adults in the country smoke cigars "every day," "someday," or "rarely". Here, Corey et al offer an expansion to the report using data from the 2012-2013 NATS to further characterize cigar smokers by the usual type of cigar smoked using the following categories: little filtered cigars (LFCs), cigarillos/other mass market cigars (cigarillos/ MMCs), and premium cigars. Results indicated that among adults who smoke cigars, 61.8% usually smoke cigarillos/MMCs, 19.9% usually smoke premium cigars, and the remainder, 18.4%, usually smoke LFCs. JF - MMWR. Morbidity and Mortality Weekly Report AU - Corey, Catherine G, MSPH AU - King, Brian A, PhD AU - Coleman, Blair N, MPH AU - Delnevo, Cristine D, PhD AU - Husten, Corinne G, MD AU - Ambrose, Bridget K, PhD AU - Apelberg, Benjamin J, PhD Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 650 EP - 4 CY - Atlanta PB - U.S. Center for Disease Control KW - Public Health And Safety KW - Public health KW - Adults KW - Smoking KW - Cigars KW - Cigarettes KW - United States--US KW - Young Adult KW - Humans KW - Health Surveys KW - Adult KW - Aged KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Tobacco Products -- statistics & numerical data KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551736413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.atitle=Little+Filtered+Cigar%2C+Cigarillo%2C+and+Premium+Cigar+Smoking+Among+Adults+-+United+States%2C+2012-2013&rft.au=Corey%2C+Catherine+G%2C+MSPH%3BKing%2C+Brian+A%2C+PhD%3BColeman%2C+Blair+N%2C+MPH%3BDelnevo%2C+Cristine+D%2C+PhD%3BHusten%2C+Corinne+G%2C+MD%3BAmbrose%2C+Bridget+K%2C+PhD%3BApelberg%2C+Benjamin+J%2C+PhD&rft.aulast=Corey&rft.aufirst=Catherine&rft.date=2014-08-01&rft.volume=63&rft.issue=30&rft.spage=650&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.issn=01492195&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Center for Disease Control Aug 2014 N1 - Document feature - Tables; Graphs; References N1 - Last updated - 2014-09-17 ER - TY - JOUR T1 - Polycyclic aromatic hydrocarbons in residential dust and risk of childhood acute lymphoblastic leukemia. AN - 1551024088; 24948546 AB - Several polycyclic aromatic hydrocarbons (PAHs) are known or probable human carcinogens. We evaluated the relationship between PAH exposure and risk of childhood acute lymphoblastic leukemia (ALL) using concentrations in residential dust as an exposure indicator. We conducted a population-based case-control study (251 ALL cases, 306 birth-certificate controls) in Northern and Central California from 2001 to 2007. We collected residential dust using a high volume small surface sampler (HVS3) (n=185 cases, 212 controls) or by sampling from participants' household vacuum cleaners (n=66 cases, 94 controls). We evaluated log-transformed concentrations of 9 individual PAHs, the summed PAHs, and the summed PAHs weighted by their carcinogenic potency (the toxic equivalence). We calculated odds ratios (ORs) and 95% confidence intervals (CI) using logistic regression adjusting for demographic characteristics and duration between diagnosis/reference date and dust collection. Among participants with HVS3 dust, risk of ALL was not associated with increasing concentration of any PAHs based on OR perln(ng/g). Among participants with vacuum dust, we observed positive associations between ALL risk and increasing concentrations of benzo[a]pyrene (OR perln[ng/g]=1.42, 95% CI=0.95, 2.12), dibenzo[a,h]anthracene (OR=1.98, 95% CI=1.11, 3.55), benzo[k]fluoranthene (OR=1.71, 95% CI=0.91, 3.22), indeno[1,2,3-cd]pyrene (OR=1.81, 95% CI=1.04, 3.16), and the toxic equivalence (OR=2.35, 95% CI=1.18, 4.69). The increased ALL risk among participants with vacuum dust suggests that PAH exposure may increase the risk of childhood ALL; however, reasons for the different results based on HVS3 dust samples deserve further study. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Environmental research AU - Deziel, N C AU - Rull, R P AU - Colt, J S AU - Reynolds, P AU - Whitehead, T P AU - Gunier, R B AU - Month, S R AU - Taggart, D R AU - Buffler, P AU - Ward, M H AU - Metayer, C AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Electronic address: nicole.deziel@yale.edu. ; School of Community Health Sciences, University of Nevada, Reno, NV, USA. ; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. ; Cancer Prevention Institute of California, Berkeley, CA, USA. ; University of California, Berkeley, CA, USA. ; Kaiser Permanente, Oakland, CA, USA. ; Kaiser Permanente, Santa Clara, CA, USA. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 388 EP - 395 VL - 133 KW - Dust KW - 0 KW - Polycyclic Aromatic Hydrocarbons KW - Index Medicus KW - Polycyclic aromatic hydrocarbons KW - Environmental epidemiology KW - Childhood leukemia KW - Environmental exposures KW - Infant KW - Housing KW - Humans KW - Case-Control Studies KW - Child KW - California -- epidemiology KW - Male KW - Female KW - Child, Preschool KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- epidemiology KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- chemically induced KW - Dust -- analysis KW - Polycyclic Aromatic Hydrocarbons -- analysis KW - Polycyclic Aromatic Hydrocarbons -- poisoning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551024088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Polycyclic+aromatic+hydrocarbons+in+residential+dust+and+risk+of+childhood+acute+lymphoblastic+leukemia.&rft.au=Deziel%2C+N+C%3BRull%2C+R+P%3BColt%2C+J+S%3BReynolds%2C+P%3BWhitehead%2C+T+P%3BGunier%2C+R+B%3BMonth%2C+S+R%3BTaggart%2C+D+R%3BBuffler%2C+P%3BWard%2C+M+H%3BMetayer%2C+C&rft.aulast=Deziel&rft.aufirst=N&rft.date=2014-08-01&rft.volume=133&rft.issue=&rft.spage=388&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=1096-0953&rft_id=info:doi/10.1016%2Fj.envres.2014.04.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-03 N1 - Date created - 2014-08-01 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Air Waste Manag Assoc. 2000 Feb;50(2):175-80 [10680346] J Environ Monit. 2004 May;6(5):413-6 [15152308] Rev Environ Contam Toxicol. 2002;175:1-46 [12206053] Occup Environ Med. 2003 Dec;60(12):901-9 [14634180] Epidemiology. 2004 Jan;15(1):6-12 [14712141] Cancer Causes Control. 2004 May;15(4):331-9 [15141134] Environ Health Perspect. 2004 Jul;112(10):1133-6 [15238289] Stat Med. 1991 Apr;10(4):585-98 [2057657] Regul Toxicol Pharmacol. 1992 Dec;16(3):290-300 [1293646] Environ Res. 1995 Feb;68(2):114-23 [7601072] Am J Epidemiol. 1996 Dec 1;144(11):1028-33 [8942433] Environ Health Perspect. 1998 Jun;106 Suppl 3:909-25 [9646055] Environ Health Perspect. 1998 Nov;106(11):721-4 [9799187] J Expo Anal Environ Epidemiol. 1999 Mar-Apr;9(2):85-98 [10321348] Mutat Res. 1999 Jul 15;443(1-2):139-47 [10415437] Mutat Res. 2004 Nov;567(2-3):401-25 [15572288] Environ Health Perspect. 2004 Dec;112(17):1691-6 [15579415] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):506-11 [15734979] Cancer Invest. 2005;23(1):60-75 [15779869] Int J Cancer. 2006 Jun 15;118(12):2920-9 [16425269] Am J Epidemiol. 2006 Jun 15;163(12):1091-100 [16597704] Environ Health. 2008;7:6 [18291036] Environ Sci Technol. 2008 Apr 1;42(7):2663-7 [18505013] Methods Mol Biol. 2009;472:103-37 [19107431] Rev Environ Contam Toxicol. 2009;201:1-39 [19484587] Environ Health Perspect. 2009 Jun;117(6):1007-13 [19590698] Int J Epidemiol. 2010 Dec;39(6):1628-37 [20889538] IARC Monogr Eval Carcinog Risks Hum. 2010;92:1-853 [21141735] J Expo Sci Environ Epidemiol. 2011 Mar-Apr;21(2):123-32 [20040932] Prev Chronic Dis. 2011 Sep;8(5):A106 [21843409] Am J Epidemiol. 2012 Jan 1;175(1):43-53 [22143821] Cancer Epidemiol Biomarkers Prev. 2012 Jul;21(7):1191-202 [22573794] J Expo Sci Environ Epidemiol. 2013 Jan-Feb;23(1):52-9 [22805987] Environ Health Perspect. 2013 May;121(5):543-50 [23461863] J Expo Sci Environ Epidemiol. 2013 Jul;23(4):363-70 [23321862] Environ Health Perspect. 2002 Jun;110 Suppl 3:451-88 [12060843] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envres.2014.04.033 ER - TY - JOUR T1 - Morphine and codeine concentrations in human urine following controlled poppy seeds administration of known opiate content. AN - 1547543220; 24887324 AB - Opiates are an important component for drug testing due to their high abuse potential. Proper urine opiate interpretation includes ruling out poppy seed ingestion; however, detailed elimination studies after controlled poppy seed administration with known morphine and codeine doses are not available. Therefore, we investigated urine opiate pharmacokinetics after controlled oral administration of uncooked poppy seeds with known morphine and codeine content. Participants were administered two 45 g oral poppy seed doses 8 h apart, each containing 15.7 mg morphine and 3mg codeine. Urine was collected ad libitum up to 32 h after the first dose. Specimens were analyzed with the Roche Opiates II immunoassay at 2000 and 300 μg/L cutoffs, and the ThermoFisher CEDIA(®) heroin metabolite (6-acetylmorphine, 6-AM) and Lin-Zhi 6-AM immunoassays with 10 μg/L cutoffs to determine if poppy seed ingestion could produce positive results in these heroin marker assays. In addition, all specimens were quantified for morphine and codeine by GC/MS. Participants (N=22) provided 391 urine specimens over 32 h following dosing; 26.6% and 83.4% were positive for morphine at 2000 and 300 μg/L GC/MS cutoffs, respectively. For the 19 subjects who completed the study, morphine concentrations ranged from <300 to 7522 μg/L with a median peak concentration of 5239 μg/L. The median first morphine-positive urine sample at 2000 μg/L cutoff concentration occurred at 6.6 h (1.2-12.1), with the last positive from 2.6 to 18 h after the second dose. No specimens were positive for codeine at a cutoff concentration of 2000 μg/L, but 20.2% exceeded 300 μg/L, with peak concentrations of 658 μg/L (284-1540). The Roche Opiates II immunoassay had efficiencies greater than 96% for the 2000 and 300 μg/L cutoffs. The CEDIA 6-AM immunoassay had a specificity of 91%, while the Lin-Zhi assay had no false positive results. These data provide valuable information for interpreting urine opiate results. Copyright © 2014. Published by Elsevier Ireland Ltd. JF - Forensic science international AU - Smith, Michael L AU - Nichols, Daniel C AU - Underwood, Paula AU - Fuller, Zachary AU - Moser, Matthew A AU - LoDico, Charles AU - Gorelick, David A AU - Newmeyer, Matthew N AU - Concheiro, Marta AU - Huestis, Marilyn A AD - U.S. Army Forensic Toxicology Drug Testing Laboratory, Fort Meade, MD, USA. ; Division of Workplace Programs, Substance Abuse Mental Health Services Administration, Department of Health and Human Services, Rockville, MD, USA. ; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA; Currently at Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. ; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA; Program in Toxicology, University of Maryland Baltimore, Baltimore, MD, USA. ; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. ; Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA. Electronic address: mhuestis@intra.nida.nih.gov. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 87 EP - 90 VL - 241 KW - Analgesics, Opioid KW - 0 KW - Morphine KW - 76I7G6D29C KW - Codeine KW - Q830PW7520 KW - Index Medicus KW - Poppy seeds KW - Urine KW - Controlled dose KW - Humans KW - Gas Chromatography-Mass Spectrometry KW - Male KW - Female KW - Immunoassay KW - Seeds KW - Morphine -- urine KW - Papaver KW - Codeine -- urine KW - Analgesics, Opioid -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1547543220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forensic+science+international&rft.atitle=Morphine+and+codeine+concentrations+in+human+urine+following+controlled+poppy+seeds+administration+of+known+opiate+content.&rft.au=Smith%2C+Michael+L%3BNichols%2C+Daniel+C%3BUnderwood%2C+Paula%3BFuller%2C+Zachary%3BMoser%2C+Matthew+A%3BLoDico%2C+Charles%3BGorelick%2C+David+A%3BNewmeyer%2C+Matthew+N%3BConcheiro%2C+Marta%3BHuestis%2C+Marilyn+A&rft.aulast=Smith&rft.aufirst=Michael&rft.date=2014-08-01&rft.volume=241&rft.issue=&rft.spage=87&rft.isbn=&rft.btitle=&rft.title=Forensic+science+international&rft.issn=1872-6283&rft_id=info:doi/10.1016%2Fj.forsciint.2014.04.042 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-21 N1 - Date created - 2014-07-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Drug Test Anal. 2014 Mar;6(3):194-201 [24339374] Ther Drug Monit. 2010 Feb;32(1):11-8 [19901868] J Anal Toxicol. 2001 Oct;25(7):504-14 [11599592] Forensic Sci Int. 1985 Feb;27(2):111-7 [3979930] Ther Drug Monit. 2006 Aug;28(4):552-8 [16885724] Anesthesiology. 1999 Apr;90(4):1026-38 [10201674] Clin Chem. 1999 Apr;45(4):510-9 [10102911] Forensic Sci Int. 1998 Jul 6;95(1):1-10 [9718666] Clin Chem. 1997 Jun;43(6 Pt 1):1029-32 [9191557] Planta Med. 1996 Dec;62(6):544-7 [9000887] J Anal Toxicol. 1991 Jul-Aug;15(4):161-6 [1943064] J Anal Toxicol. 1991 Mar-Apr;15(2):49-53 [2051744] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.forsciint.2014.04.042 ER - TY - JOUR T1 - Selection and characterization of a Patagonian Pichia kudriavzevii for wine deacidification AN - 1546081333 AB - Aims The purpose of this study was to select autochthonous yeasts with metabolic ability to degrade L-malic acid for its potential use in young wine deacidification. Methods and Results Fifty seven Patagonian nonSaccharomyces yeast of oenological origin were identified by conventional molecular methods and tested in their capability to grow at the expense of L-malic acid. Only four isolates belonging to Pichia kudriavzevii species showed this property, and one of them was selected to continue with the study. This isolate, named as P. kudriavzevii ÑNI15, was able to degrade L-malic acid in microvinifications, increasing the pH 0·2-0·3 units with a minimal effect on the acid structure of wine. Additionally, this isolate produced low levels of ethanol, important levels of glycerol (10·41 ± 0·48 g l-1) and acceptable amounts of acetic acid (0·86 ± 0·13 g l-1). In addition, it improved the sensorial attributes of wine increasing its fruity aroma. Conclusions The selection of yeasts for oenological use among nonSaccharomyces species led to the finding of a yeast strain with novel and interesting oenological characteristics which could have significant implications in the production of well-balanced and more physicochemical and microbiological stable young wines. Significance and Impact of the Study The use of P. kudriavzeviiÑNI15 as mixed starter with S. cerevisiae would eliminate the cultural and cellar operations undertaken to adjust the musts acidity, therefore improving wine quality and reducing production costs. [PUBLICATION ABSTRACT] JF - Journal of Applied Microbiology AU - Monaco, SM AU - Barda, NB AU - Rubio, NC AU - Caballero, AC Y1 - 2014/08// PY - 2014 DA - Aug 2014 SP - 451 EP - 464 CY - London PB - Wiley Subscription Services, Inc. VL - 117 IS - 2 SN - 13645072 KW - Biology--Microbiology KW - Yeast KW - Metabolism KW - Microbiology KW - Wines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1546081333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvscijournals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Microbiology&rft.atitle=Selection+and+characterization+of+a+Patagonian+Pichia+kudriavzevii+for+wine+deacidification&rft.au=Monaco%2C+SM%3BBarda%2C+NB%3BRubio%2C+NC%3BCaballero%2C+AC&rft.aulast=Monaco&rft.aufirst=SM&rft.date=2014-08-01&rft.volume=117&rft.issue=2&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Microbiology&rft.issn=13645072&rft_id=info:doi/10.1111%2Fjam.12547 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright © 2014 The Society for Applied Microbiology N1 - Document feature - References N1 - Last updated - 2014-08-06 N1 - CODEN - JAMIFK DO - http://dx.doi.org/10.1111/jam.12547 ER - TY - JOUR T1 - A mutation in the extracellular domain of the α7 nAChR reduces calcium permeability. AN - 1544736798; 24177919 AB - The α7 neuronal nicotinic acetylcholine receptor (nAChR) displays the highest calcium permeability among the different subtypes of nAChRs expressed in the mammalian brain and can impact cellular events including neurotransmitter release, second messenger cascades, cell survival, and apoptosis. The selectivity for cations in nAChRs is thought to be achieved in part by anionic residues which are located on either side of the channel mouth and increase relative cationic concentration. Mutagenesis studies have improved our understanding of the role of the second transmembrane domain and the intracellular loop of the channel in ion selectivity. However, little is known about the influence that the extracellular domain (ECD) plays in ion permeation. In the α7 nAChR, it has been found that the ECD contains a ring of ten aspartates (two per subunit) that is believed to face the lumen of the pore and could attract cations for permeation. Using mutagenesis and a combination of electrophysiology and imaging techniques, we tested the possible involvement of these aspartate residues in the calcium permeability of the rat α7 nAChR. We found that one of these residues (the aspartate at position 44) appears to be essential since mutating it to alanine resulted in a decrease in amplitude for both whole cell and single-channel responses and in the complete disappearance of detectable calcium changes in most cells, which indicates that the ECD of the α7 nAChR plays a key role in calcium permeation. JF - Pflugers Archiv : European journal of physiology AU - Colón-Sáez, José O AU - Yakel, Jerrel L AD - Laboratory of Neurobiology, National Institute of Environmental Health Science, National Institutes of Health, Department of Health and Human Services, PO Box 12233, Research Triangle Park, NC, 27709, USA. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 1571 EP - 1579 VL - 466 IS - 8 KW - Protein Subunits KW - 0 KW - alpha7 Nicotinic Acetylcholine Receptor KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rats KW - Animals KW - Protein Structure, Tertiary -- genetics KW - Patch-Clamp Techniques KW - Extracellular Space -- metabolism KW - Cells, Cultured KW - Calcium -- metabolism KW - Protein Subunits -- genetics KW - Neurons -- metabolism KW - alpha7 Nicotinic Acetylcholine Receptor -- metabolism KW - alpha7 Nicotinic Acetylcholine Receptor -- genetics KW - Protein Subunits -- metabolism KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1544736798?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pflugers+Archiv+%3A+European+journal+of+physiology&rft.atitle=A+mutation+in+the+extracellular+domain+of+the+%CE%B17+nAChR+reduces+calcium+permeability.&rft.au=Col%C3%B3n-S%C3%A1ez%2C+Jos%C3%A9+O%3BYakel%2C+Jerrel+L&rft.aulast=Col%C3%B3n-S%C3%A1ez&rft.aufirst=Jos%C3%A9&rft.date=2014-08-01&rft.volume=466&rft.issue=8&rft.spage=1571&rft.isbn=&rft.btitle=&rft.title=Pflugers+Archiv+%3A+European+journal+of+physiology&rft.issn=1432-2013&rft_id=info:doi/10.1007%2Fs00424-013-1385-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-23 N1 - Date created - 2014-07-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3643-8 [10716716] J Biol Chem. 2011 May 6;286(18):16008-17 [21454663] Neuropharmacology. 2000 Oct;39(13):2799-807 [11044750] Biol Psychiatry. 2001 Feb 1;49(3):233-9 [11230874] Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4148-53 [11259680] Eur J Neurosci. 2001 May;13(10):1849-60 [11403678] J Physiol. 2002 Apr 15;540(Pt 2):425-34 [11956333] Mol Cell Neurosci. 2002 Dec;21(4):616-25 [12504594] Nature. 2003 Jan 23;421(6921):384-8 [12508119] Neuron. 2003 Jun 19;38(6):929-39 [12818178] J Neurosci. 2003 Nov 5;23(31):10093-9 [14602824] Cell Calcium. 2004 Jan;35(1):1-8 [14670366] Trends Pharmacol Sci. 2004 Jun;25(6):317-24 [15165747] J Physiol. 2011 Jul 1;589(Pt 13):3163-74 [21540349] J Clin Pharm Ther. 2011 Aug;36(4):437-45 [21729110] Neuron. 2011 Jul 14;71(1):155-65 [21745645] Biochem Pharmacol. 2011 Oct 15;82(8):931-42 [21763291] Nat Neurosci. 2011 Oct;14(10):1253-9 [21909087] Neuroscience. 2011 Nov 10;195:21-36 [21884762] Int J Mol Sci. 2012;13(2):2219-38 [22408449] Curr Drug Targets. 2012 May;13(5):623-30 [22300030] J Mol Neurosci. 2012 Sep;48(1):14-21 [22351110] J Neurosci. 2012 Sep 5;32(36):12337-48 [22956824] Mol Pharmacol. 2013 Sep;84(3):459-75 [23839567] J Neurosci. 1990 Oct;10(10):3413-20 [2170596] Nature. 1992 Oct 8;359(6395):500-5 [1383829] Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6971-5 [7688468] Biophys J. 1995 Feb;68(2):516-24 [7696505] J Pharmacol Exp Ther. 1997 Jan;280(1):428-38 [8996225] J Physiol. 1998 Mar 15;507 ( Pt 3):749-57 [9508836] J Neurosci. 1998 Sep 1;18(17):6871-81 [9712657] J Physiol. 2005 Aug 1;566(Pt 3):759-68 [15932886] Mol Pharmacol. 2005 Nov;68(5):1431-8 [16120769] J Physiol. 2006 May 15;573(Pt 1):35-43 [16527851] J Physiol. 2007 Mar 15;579(Pt 3):753-63 [17204496] Proc Natl Acad Sci U S A. 2007 May 8;104(19):8059-64 [17470817] J Neurosci. 2007 May 23;27(21):5683-93 [17522313] Front Biosci. 2007;12:5030-8 [17569627] Eur J Neurosci. 2008 Mar;27(5):1097-110 [18312591] PLoS Comput Biol. 2008 Feb;4(2):e41 [18282090] J Physiol. 2009 Mar 1;587(Pt 5):1033-42 [19124535] Glia. 2009 Aug 1;57(10):1104-14 [19170184] Neurochem Res. 2009 Oct;34(10):1805-15 [19381804] Nat Methods. 2009 Dec;6(12):875-81 [19898485] Annu Rev Pharmacol Toxicol. 2000;40:431-58 [10836143] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00424-013-1385-y ER - TY - JOUR T1 - Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes AN - 1544013686; 20184256 AB - (+)-Usnic acid (UA) is consumed as a dietary supplement to promote weight loss; however, dietary supplements containing UA have been associated with clinical cases of severe liver injury. UA has been shown to be hepatotoxic in rats and is extensively metabolized by hepatic cytochrome P450s (CYPs); therefore, we examined if UA metabolism results in the formation of cytotoxic metabolites or if metabolism is a detoxification process in primary rat hepatocytes. When CYP activity was suppressed by the non-isoenzyme-selective inhibitor SKF-525A (20 mu M), or the CYP1A inhibitor alpha-naphthoflavone (10 mu M), or the CYP3A inhibitor ketoconazole (25 mu M), the cytotoxicity of UA at 3~6 mu M after 3~20h of exposure was significantly increased as measured by lactate dehydrogenase (LDH) leakage. At 2h after UA exposure, an earlier time point prior to LDH release, these CYP inhibitors potentiated UA-induced inhibition of cellular respiration as determined by the Clark type oxygen electrode. Cellular adenosine triphosphate (ATP) depletion by UA was also exacerbated by these CYP inhibitors. The CYP2B/2C inhibitor, ticlopidine at 20 mu M, showed no effects in parallel experiments. These data demonstrate that UA is bio-transformed to less toxic metabolites in rat primary hepatocytes, probably mainly by CYP1A and 3A, but not 2B/2C. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. (+)-Usnic acid (UA) may cause hepatotoxicity. We examined if its metabolism plays a role in toxicity in primary rat hepatocytes. When cytochrome P450 (CYP) activity was suppressed by pan-CYP inhibitor SKF-525A, or CYP1A inhibitor alpha-naphthoflavone, or CYP3A inhibitor ketoconazole, UA induced inhibition of cellular respiration, adenosine triphosphate depletion and cytotoxicity was significantly increased. The CYP2B/2C inhibitor ticlopidine showed no effects. We suggest UA is bio-transformed to less toxic metabolites in rat hepatocytes, mainly by CYP1A and 3A, but not 2B/2C. JF - Journal of Applied Toxicology AU - Shi, Qiang AU - Greenhaw, James AU - Salminen, William F AD - Division of Systems Biology, National Center for Toxicological Research, U.S. FDA, 3900 NCTR Road, Jefferson, AR, 72079, USA. PY - 2014 SP - 835 EP - 840 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 34 IS - 8 SN - 0260-437X, 0260-437X KW - Toxicology Abstracts KW - ticlopidine KW - Detoxification KW - Leakage KW - Data processing KW - Injuries KW - Hepatocytes KW - Respiration KW - ATP KW - Metabolites KW - Toxicity KW - Ketoconazole KW - L-Lactate dehydrogenase KW - Oxygen KW - Cytotoxicity KW - CYP1A protein KW - Dietary supplements KW - Electrodes KW - Liver KW - Cytochrome P450 KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1544013686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Inhibition+of+cytochrome+P450s+enhances+%28%2B%29-usnic+acid+cytotoxicity+in+primary+cultured+rat+hepatocytes&rft.au=Shi%2C+Qiang%3BGreenhaw%2C+James%3BSalminen%2C+William+F&rft.aulast=Shi&rft.aufirst=Qiang&rft.date=2014-08-01&rft.volume=34&rft.issue=8&rft.spage=835&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.2892 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Detoxification; ticlopidine; Data processing; Leakage; Injuries; Hepatocytes; Respiration; ATP; Metabolites; Toxicity; Ketoconazole; L-Lactate dehydrogenase; Oxygen; Cytotoxicity; CYP1A protein; Dietary supplements; Electrodes; Liver; Cytochrome P450 DO - http://dx.doi.org/10.1002/jat.2892 ER - TY - JOUR T1 - Sertraline induces endoplasmic reticulum stress in hepatic cells. AN - 1542009736; 24865413 AB - Sertraline is used for the treatment of depression, and is also used for the treatment of panic, obsessive-compulsive, and post-traumatic stress disorders. Previously, we have demonstrated that sertraline caused hepatic cytotoxicity, with mitochondrial dysfunction and apoptosis being underlying mechanisms. In this study, we used microarray and other biochemical and molecular analyses to identify endoplasmic reticulum (ER) stress as a novel molecular mechanism. HepG2 cells were exposed to sertraline and subjected to whole genome gene expression microarray analysis. Pathway analysis revealed that ER stress is among the significantly affected biological changes. We confirmed the increased expression of ER stress makers by real-time PCR and Western blots. The expression of typical ER stress markers such as PERK, IRE1α, and CHOP was significantly increased. To study better ER stress-mediated drug-induced liver toxicity; we established in vitro systems for monitoring ER stress quantitatively and efficiently, using Gaussia luciferase (Gluc) and secreted alkaline phosphatase (SEAP) as ER stress reporters. These in vitro systems were validated using well-known ER stress inducers. In these two reporter assays, sertraline inhibited the secretion of Gluc and SEAP. Moreover, we demonstrated that sertraline-induced apoptosis was coupled to ER stress and that the apoptotic effect was attenuated by 4-phenylbutyrate, a potent ER stress inhibitor. In addition, we showed that the MAP4K4-JNK signaling pathway contributed to the process of sertraline-induced ER stress. In summary, we demonstrated that ER stress is a mechanism of sertraline-induced liver toxicity. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Chen, Si AU - Xuan, Jiekun AU - Couch, Letha AU - Iyer, Advait AU - Wu, Yuanfeng AU - Li, Quan-Zhen AU - Guo, Lei AD - Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA; Biological Sciences, University of Maryland, Baltimore, MD 21250, USA. ; Department of Immunology and Internal Medicine, Microarray Core Facility, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA. Electronic address: Lei.Guo@fda.hhs.gov. Y1 - 2014/08/01/ PY - 2014 DA - 2014 Aug 01 SP - 78 EP - 88 VL - 322 KW - Biomarkers KW - 0 KW - RNA, Messenger KW - Serotonin Uptake Inhibitors KW - Alkaline Phosphatase KW - EC 3.1.3.1 KW - Caspase 3 KW - EC 3.4.22.- KW - Caspase 7 KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - MAPK pathway KW - Endoplasmic reticulum stress KW - Apoptosis KW - Reporter gene assay KW - Drug-induced liver toxicity KW - Real-Time Polymerase Chain Reaction KW - Gene Expression -- drug effects KW - RNA Splicing -- drug effects KW - Caspase 7 -- metabolism KW - Humans KW - Alkaline Phosphatase -- metabolism KW - RNA, Messenger -- genetics KW - RNA, Messenger -- biosynthesis KW - Polymerase Chain Reaction KW - Blotting, Western KW - Genetic Vectors KW - Apoptosis -- drug effects KW - Microarray Analysis KW - Cell Line KW - Caspase 3 -- metabolism KW - Hepatocytes -- drug effects KW - Sertraline -- pharmacology KW - Serotonin Uptake Inhibitors -- pharmacology KW - Hepatocytes -- metabolism KW - Endoplasmic Reticulum Stress -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1542009736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Sertraline+induces+endoplasmic+reticulum+stress+in+hepatic+cells.&rft.au=Chen%2C+Si%3BXuan%2C+Jiekun%3BCouch%2C+Letha%3BIyer%2C+Advait%3BWu%2C+Yuanfeng%3BLi%2C+Quan-Zhen%3BGuo%2C+Lei&rft.aulast=Chen&rft.aufirst=Si&rft.date=2014-08-01&rft.volume=322&rft.issue=&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2014.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-08-25 N1 - Date created - 2014-06-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2014.05.007 ER - TY - JOUR T1 - Animal models that best reproduce the clinical manifestations of human intoxication with organophosphorus compounds. AN - 1541379330; 24907067 AB - The translational capacity of data generated in preclinical toxicological studies is contingent upon several factors, including the appropriateness of the animal model. The primary objectives of this article are: 1) to analyze the natural history of acute and delayed signs and symptoms that develop following an acute exposure of humans to organophosphorus (OP) compounds, with an emphasis on nerve agents; 2) to identify animal models of the clinical manifestations of human exposure to OPs; and 3) to review the mechanisms that contribute to the immediate and delayed OP neurotoxicity. As discussed in this study, clinical manifestations of an acute exposure of humans to OP compounds can be faithfully reproduced in rodents and nonhuman primates. These manifestations include an acute cholinergic crisis in addition to signs of neurotoxicity that develop long after the OP exposure, particularly chronic neurologic deficits consisting of anxiety-related behavior and cognitive deficits, structural brain damage, and increased slow electroencephalographic frequencies. Because guinea pigs and nonhuman primates, like humans, have low levels of circulating carboxylesterases-the enzymes that metabolize and inactivate OP compounds-they stand out as appropriate animal models for studies of OP intoxication. These are critical points for the development of safe and effective therapeutic interventions against OP poisoning because approval of such therapies by the Food and Drug Administration is likely to rely on the Animal Efficacy Rule, which allows exclusive use of animal data as evidence of the effectiveness of a drug against pathologic conditions that cannot be ethically or feasibly tested in humans. U.S. Government work not protected by U.S. copyright. JF - The Journal of pharmacology and experimental therapeutics AU - Pereira, Edna F R AU - Aracava, Yasco AU - DeTolla, Louis J AU - Beecham, E Jeffrey AU - Basinger, G William AU - Wakayama, Edgar J AU - Albuquerque, Edson X AD - Division of Translational Toxicology, Department of Epidemiology and Public Health (E.F.R.P., Y.A., E.X.A.), and Program of Comparative Medicine and Departments of Pathology, Medicine, and Epidemiology and Public Health (L.J.D.), University of Maryland School of Medicine, Baltimore, Maryland; Countervail Corporation, Charlotte, North Carolina (E.J.B., G.W.B.); and Biomedical Advanced Research and Development Authority and Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC (E.J.W.). ; Division of Translational Toxicology, Department of Epidemiology and Public Health (E.F.R.P., Y.A., E.X.A.), and Program of Comparative Medicine and Departments of Pathology, Medicine, and Epidemiology and Public Health (L.J.D.), University of Maryland School of Medicine, Baltimore, Maryland; Countervail Corporation, Charlotte, North Carolina (E.J.B., G.W.B.); and Biomedical Advanced Research and Development Authority and Office of the Assistant Secretary for Preparedness and Response, Department of Health and Human Services, Washington, DC (E.J.W.) ealbuquerque@som.umaryland.edu. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 313 EP - 321 VL - 350 IS - 2 KW - Organophosphorus Compounds KW - 0 KW - Index Medicus KW - Animals KW - Maze Learning -- drug effects KW - Guinea Pigs KW - Anxiety -- chemically induced KW - Humans KW - Lethal Dose 50 KW - Organophosphorus Compounds -- toxicity KW - Electroencephalography -- drug effects KW - Models, Animal KW - Organophosphate Poisoning -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541379330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Animal+models+that+best+reproduce+the+clinical+manifestations+of+human+intoxication+with+organophosphorus+compounds.&rft.au=Pereira%2C+Edna+F+R%3BAracava%2C+Yasco%3BDeTolla%2C+Louis+J%3BBeecham%2C+E+Jeffrey%3BBasinger%2C+G+William%3BWakayama%2C+Edgar+J%3BAlbuquerque%2C+Edson+X&rft.aulast=Pereira&rft.aufirst=Edna+F&rft.date=2014-08-01&rft.volume=350&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=1521-0103&rft_id=info:doi/10.1124%2Fjpet.114.214932 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-08-26 N1 - Date created - 2014-06-27 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Brain Res. 1993 Aug 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http://dx.doi.org/10.1124/jpet.114.214932 ER - TY - JOUR T1 - Neoplastic-like transformation effect of single-walled and multi-walled carbon nanotubes compared to asbestos on human lung small airway epithelial cells. AN - 1467635738; 23634900 AB - Accumulating evidence indicates that carbon nanotubes (CNTs) are biopersistent and can cause lung damage. With similar fibrous morphology and mode of exposure to asbestos, a known human carcinogen, growing concern has arisen for elevated risk of CNT-induced lung carcinogenesis; however, relatively little is known about the long-term carcinogenic effect of CNT. Neoplastic transformation is a key early event leading to carcinogenesis. We studied the ability of single- and multi-walled CNTs to induce neoplastic transformation of human lung epithelial cells compared to asbestos. Long-term (6-month) exposure of the cells to occupationally relevant concentrations of CNT in culture caused a neoplastic-like transformation phenotype as demonstrated by increased cell proliferation, anchorage-independent growth, invasion and angiogenesis. Whole-genome expression signature and protein expression analyses showed that single- and multi-walled CNTs shared similar signaling signatures which were distinct from asbestos. These results provide novel toxicogenomic information and suggest distinct particle-associated mechanisms of neoplasia promotion induced by CNTs and asbestos. JF - Nanotoxicology AU - Wang, Liying AU - Stueckle, Todd A AU - Mishra, Anurag AU - Derk, Raymond AU - Meighan, Terence AU - Castranova, Vincent AU - Rojanasakul, Yon AD - HELD/PPRB, National Institute for Occupational Safety and Health , Morgantown, WV 26505 , USA. Y1 - 2014/08// PY - 2014 DA - August 2014 SP - 485 EP - 507 VL - 8 IS - 5 KW - Nanotubes, Carbon KW - 0 KW - Proteins KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Gene Expression Profiling KW - Epithelial Cells -- cytology KW - Humans KW - Signal Transduction -- drug effects KW - Proteins -- analysis KW - Proteins -- metabolism KW - Proteins -- genetics KW - Cell Line KW - Respiratory Mucosa -- cytology KW - Cell Transformation, Neoplastic -- drug effects KW - Asbestos -- toxicity KW - Nanotubes, Carbon -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1467635738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Neoplastic-like+transformation+effect+of+single-walled+and+multi-walled+carbon+nanotubes+compared+to+asbestos+on+human+lung+small+airway+epithelial+cells.&rft.au=Wang%2C+Liying%3BStueckle%2C+Todd+A%3BMishra%2C+Anurag%3BDerk%2C+Raymond%3BMeighan%2C+Terence%3BCastranova%2C+Vincent%3BRojanasakul%2C+Yon&rft.aulast=Wang&rft.aufirst=Liying&rft.date=2014-08-01&rft.volume=8&rft.issue=5&rft.spage=485&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=1743-5404&rft_id=info:doi/10.3109%2F17435390.2013.801089 LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/17435390.2013.801089 ER - TY - CPAPER T1 - Background Information on the Concerns of Nutrient Runoff to Sensitive and Protected Water Body Ecosystems in Florida. T2 - 2014 Annual Conference of the American Society for Horticultural Science (ASHS 2014) AN - 1541355632; 6289033 JF - 2014 Annual Conference of the American Society for Horticultural Science (ASHS 2014) AU - Henriques, William Y1 - 2014/07/28/ PY - 2014 DA - 2014 Jul 28 KW - Ecosystems KW - USA, Florida KW - Nutrients KW - Water bodies KW - Runoff UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541355632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Conference+of+the+American+Society+for+Horticultural+Science+%28ASHS+2014%29&rft.atitle=Background+Information+on+the+Concerns+of+Nutrient+Runoff+to+Sensitive+and+Protected+Water+Body+Ecosystems+in+Florida.&rft.au=Henriques%2C+William&rft.aulast=Henriques&rft.aufirst=William&rft.date=2014-07-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Conference+of+the+American+Society+for+Horticultural+Science+%28ASHS+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://ashs.confex.com/ashs/2014/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - The shift from reaction to prevention for animal feedstuffs T2 - 2014 American Dairy Science Association- American Society of Animal Science and and the Canadian Society of Animal Science Annual Meeting (JAM 2014) AN - 1548625424; 6289452 JF - 2014 American Dairy Science Association- American Society of Animal Science and and the Canadian Society of Animal Science Annual Meeting (JAM 2014) AU - McChesney, D Y1 - 2014/07/20/ PY - 2014 DA - 2014 Jul 20 KW - Prevention UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548625424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+American+Dairy+Science+Association-+American+Society+of+Animal+Science+and+and+the+Canadian+Society+of+Animal+Science+Annual+Meeting+%28JAM+2014%29&rft.atitle=The+shift+from+reaction+to+prevention+for+animal+feedstuffs&rft.au=McChesney%2C+D&rft.aulast=McChesney&rft.aufirst=D&rft.date=2014-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+American+Dairy+Science+Association-+American+Society+of+Animal+Science+and+and+the+Canadian+Society+of+Animal+Science+Annual+Meeting+%28JAM+2014%29&rft.issn=&rft_id=info:doi/ L2 - https://www.asas.org/docs/default-source/jam2014/jam_program_june4.pdf?sfvrsn=0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-30 N1 - Last updated - 2014-07-28 ER - TY - CPAPER T1 - Food safety. What efforts are underway internationally to improve food safety? FDA's Office of International T2 - 2014 American Dairy Science Association- American Society of Animal Science and and the Canadian Society of Animal Science Annual Meeting (JAM 2014) AN - 1548623674; 6289982 JF - 2014 American Dairy Science Association- American Society of Animal Science and and the Canadian Society of Animal Science Annual Meeting (JAM 2014) AU - Bryant, C Y1 - 2014/07/20/ PY - 2014 DA - 2014 Jul 20 KW - Food KW - FDA KW - Food contamination KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548623674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+American+Dairy+Science+Association-+American+Society+of+Animal+Science+and+and+the+Canadian+Society+of+Animal+Science+Annual+Meeting+%28JAM+2014%29&rft.atitle=Food+safety.+What+efforts+are+underway+internationally+to+improve+food+safety%3F+FDA%27s+Office+of+International&rft.au=Bryant%2C+C&rft.aulast=Bryant&rft.aufirst=C&rft.date=2014-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+American+Dairy+Science+Association-+American+Society+of+Animal+Science+and+and+the+Canadian+Society+of+Animal+Science+Annual+Meeting+%28JAM+2014%29&rft.issn=&rft_id=info:doi/ L2 - https://www.asas.org/docs/default-source/jam2014/jam_program_june4.pdf?sfvrsn=0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-30 N1 - Last updated - 2014-07-28 ER - TY - CPAPER T1 - Regulatory definitions, processes, and functionality assessment for animal food T2 - 2014 American Dairy Science Association- American Society of Animal Science and and the Canadian Society of Animal Science Annual Meeting (JAM 2014) AN - 1548623515; 6289702 JF - 2014 American Dairy Science Association- American Society of Animal Science and and the Canadian Society of Animal Science Annual Meeting (JAM 2014) AU - Alewynse, M AU - Benz, S Y1 - 2014/07/20/ PY - 2014 DA - 2014 Jul 20 KW - Food UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548623515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+American+Dairy+Science+Association-+American+Society+of+Animal+Science+and+and+the+Canadian+Society+of+Animal+Science+Annual+Meeting+%28JAM+2014%29&rft.atitle=Regulatory+definitions%2C+processes%2C+and+functionality+assessment+for+animal+food&rft.au=Alewynse%2C+M%3BBenz%2C+S&rft.aulast=Alewynse&rft.aufirst=M&rft.date=2014-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+American+Dairy+Science+Association-+American+Society+of+Animal+Science+and+and+the+Canadian+Society+of+Animal+Science+Annual+Meeting+%28JAM+2014%29&rft.issn=&rft_id=info:doi/ L2 - https://www.asas.org/docs/default-source/jam2014/jam_program_june4.pdf?sfvrsn=0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-30 N1 - Last updated - 2014-07-28 ER - TY - JOUR T1 - Interactive effects of cerium oxide and diesel exhaust nanoparticles on inducing pulmonary fibrosis. AN - 1534466440; 24793434 AB - Cerium compounds have been used as a fuel-borne catalyst to lower the generation of diesel exhaust particles (DEPs), but are emitted as cerium oxide nanoparticles (CeO2) along with DEP in the diesel exhaust. The present study investigates the effects of the combined exposure to DEP and CeO2 on the pulmonary system in a rat model. Specific pathogen-free male Sprague-Dawley rats were exposed to CeO2 and/or DEP via a single intratracheal instillation and were sacrificed at various time points post-exposure. This investigation demonstrated that CeO2 induces a sustained inflammatory response, whereas DEP elicits a switch of the pulmonary immune response from Th1 to Th2. Both CeO2 and DEP activated AM and lymphocyte secretion of the proinflammatory cytokines IL-12 and IFN-γ, respectively. However, only DEP enhanced the anti-inflammatory cytokine IL-10 production in response to ex vivo LPS or Concanavalin A challenge that was not affected by the presence of CeO2, suggesting that DEP suppresses host defense capability by inducing the Th2 immunity. The micrographs of lymph nodes show that the particle clumps in DEP+CeO2 were significantly larger than CeO2 or DEP, exhibiting dense clumps continuous throughout the lymph nodes. Morphometric analysis demonstrates that the localization of collagen in the lung tissue after DEP+CeO2 reflects the combination of DEP-exposure plus CeO2-exposure. At 4 weeks post-exposure, the histological features demonstrated that CeO2 induced lung phospholipidosis and fibrosis. DEP induced lung granulomas that were not significantly affected by the presence of CeO2 in the combined exposure. Using CeO2 as diesel fuel catalyst may cause health concerns. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Ma, Jane Y C AU - Young, Shih-Houng AU - Mercer, Robert R AU - Barger, Mark AU - Schwegler-Berry, Diane AU - Ma, Joseph K AU - Castranova, Vincent AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. Electronic address: jym1@cdc.gov. ; Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA. ; School of Pharmacy, West Virginia University, Morgantown, WV 26506, USA. Y1 - 2014/07/15/ PY - 2014 DA - 2014 Jul 15 SP - 135 EP - 147 VL - 278 IS - 2 KW - Particulate Matter KW - 0 KW - Vehicle Emissions KW - Cerium KW - 30K4522N6T KW - ceric oxide KW - 619G5K328Y KW - Index Medicus KW - Pulmonary inflammation KW - Nanoparticle KW - Cerium oxide KW - Lung fibrosis KW - Diesel exhaust particles KW - Lymphatic system KW - Rats KW - Particulate Matter -- toxicity KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Particulate Matter -- analysis KW - Male KW - Vehicle Emissions -- toxicity KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Nanoparticles -- analysis KW - Cerium -- analysis KW - Nanoparticles -- toxicity KW - Cerium -- toxicity KW - Vehicle Emissions -- analysis KW - Inhalation Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534466440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Interactive+effects+of+cerium+oxide+and+diesel+exhaust+nanoparticles+on+inducing+pulmonary+fibrosis.&rft.au=Ma%2C+Jane+Y+C%3BYoung%2C+Shih-Houng%3BMercer%2C+Robert+R%3BBarger%2C+Mark%3BSchwegler-Berry%2C+Diane%3BMa%2C+Joseph+K%3BCastranova%2C+Vincent&rft.aulast=Ma&rft.aufirst=Jane+Y&rft.date=2014-07-15&rft.volume=278&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2014.04.019 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-08-05 N1 - Date created - 2014-06-09 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Ind Med. 1995 Mar;27(3):349-58 [7747741] Environ Health Perspect. 2003 Apr;111(4):524-30 [12676610] Regul Toxicol Pharmacol. 1996 Aug;24(1 Pt 1):30-44 [8921544] Allergy. 1997;52(38 Suppl):52-6; discussion 57-8 [9208060] Cytokine. 2003 Oct;24(1-2):25-35 [14561488] Toxicol Sci. 2004 Feb;77(2):263-71 [14657513] Nat Rev Immunol. 2004 Aug;4(8):583-94 [15286725] Am Rev Respir Dis. 1978 May;117(5):879-91 [26302] Histochem J. 1979 Jul;11(4):447-55 [91593] Int J Environ Anal Chem. 1981;9(2):93-144 [7012053] Environ Health Perspect. 1983 Jan;47:65-80 [6186484] Sci Total Environ. 1982 Dec;26(1):19-32 [7167813] Chest. 1983 May;83(5):780-3 [6839821] J Appl Toxicol. 1981 Apr;1(2):77-82 [6206117] Fundam Appl Toxicol. 1985 Apr;5(2):240-50 [2580752] Am J Ind Med. 1986;9(6):567-75 [3740074] Fundam Appl Toxicol. 1987 Aug;9(2):208-21 [2443412] J Exp Med. 1988 Mar 1;167(3):1253-8 [3127525] Med J Aust. 1990 Dec 3-17;153(11-12):726-30 [2247001] Res Rep Health Eff Inst. 1991 May;(40):1-24 [1716915] Am J Respir Cell Mol Biol. 1992 Feb;6(2):235-43 [1540387] N Engl J Med. 1993 Dec 9;329(24):1753-9 [8179653] Occup Environ Med. 1994 Mar;51(3):195-9 [8130849] Exp Lung Res. 1995 Jan-Feb;21(1):67-77 [7537210] J Biol Chem. 1959 Mar;234(3):466-8 [13641241] Toxicol Sci. 2005 Jan;83(1):155-65 [15483187] Clin Rev Allergy Immunol. 2005 Jun;28(3):177-86 [16129902] Toxicol Sci. 2005 Nov;88(1):202-12 [16107553] Toxicol Sci. 2005 Nov;88(1):73-81 [16107554] Eur J Pharmacol. 2006 Mar 8;533(1-3):133-44 [16487964] J Pharmacol Exp Ther. 2006 Aug;318(2):741-50 [16690722] J Toxicol Environ Health A. 2007 May 15;70(10):820-8 [17454558] Toxicology. 2009 May 17;259(3):113-21 [19428951] Crit Rev Toxicol. 2011 Mar;41(3):213-29 [21244219] Nanotoxicology. 2011 Sep;5(3):312-25 [20925443] Clin Sci (Lond). 2012 Feb;122(4):143-59 [22029668] Int J Nanomedicine. 2011;6:2327-35 [22072870] Environ Res. 2012 May;115:1-10 [22507957] Mod Pathol. 1995 Oct;8(8):859-65 [8552576] Curr Opin Pulm Med. 1996 Sep;2(5):405-11 [9363175] J Toxicol Environ Health A. 1999 Nov 12;58(5):261-78 [10598952] Exp Lung Res. 2000 Mar;26(2):71-88 [10742923] J Trace Elem Med Biol. 2001 Apr;14(4):232-6 [11396783] Environ Health Perspect. 2001 May;109(5):515-21 [11401764] Environ Health Perspect. 2002 Nov;110(11):1105-11 [12417481] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2002 Nov;20(2):117-47 [12515672] Toxicol Appl Pharmacol. 2012 Aug 1;262(3):255-64 [22613087] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2014.04.019 ER - TY - JOUR T1 - Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway. AN - 1544736661; 25012808 AB - The U.S. Tox21 program has screened a library of approximately 10,000 (10K) environmental chemicals and drugs in three independent runs for estrogen receptor alpha (ERα) agonist and antagonist activity using two types of ER reporter gene cell lines, one with an endogenous full length ERα (ER-luc; BG1 cell line) and the other with a transfected partial receptor consisting of the ligand binding domain (ER-bla; ERα β-lactamase cell line), in a quantitative high-throughput screening (qHTS) format. The ability of the two assays to correctly identify ERα agonists and antagonists was evaluated using a set of 39 reference compounds with known ERα activity. Although both assays demonstrated adequate (i.e. >80%) predictivity, the ER-luc assay was more sensitive and the ER-bla assay more specific. The qHTS assay results were compared with results from previously published ERα binding assay data and showed >80% consistency. Actives identified from both the ER-bla and ER-luc assays were analyzed for structure-activity relationships (SARs) revealing known and potentially novel ERα active structure classes. The results demonstrate the feasibility of qHTS to identify environmental chemicals with the potential to interact with the ERα signaling pathway and the two different assay formats improve the confidence in correctly identifying these chemicals. JF - Scientific reports AU - Huang, Ruili AU - Sakamuru, Srilatha AU - Martin, Matt T AU - Reif, David M AU - Judson, Richard S AU - Houck, Keith A AU - Casey, Warren AU - Hsieh, Jui-Hua AU - Shockley, Keith R AU - Ceger, Patricia AU - Fostel, Jennifer AU - Witt, Kristine L AU - Tong, Weida AU - Rotroff, Daniel M AU - Zhao, Tongan AU - Shinn, Paul AU - Simeonov, Anton AU - Dix, David J AU - Austin, Christopher P AU - Kavlock, Robert J AU - Tice, Raymond R AU - Xia, Menghang AD - NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. ; National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA. ; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. ; ILS Inc., Research Triangle Park, NC 27709, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR 72079, USA. Y1 - 2014/07/11/ PY - 2014 DA - 2014 Jul 11 SP - 5664 VL - 4 KW - Estrogen Receptor alpha KW - 0 KW - Ligands KW - Small Molecule Libraries KW - Index Medicus KW - Protein Binding -- drug effects KW - Humans KW - HEK293 Cells KW - High-Throughput Screening Assays -- methods KW - Genes, Reporter -- drug effects KW - Cell Line KW - Structure-Activity Relationship KW - Small Molecule Libraries -- pharmacology KW - Signal Transduction -- drug effects KW - Estrogen Receptor alpha -- antagonists & inhibitors KW - Estrogen Receptor alpha -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1544736661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scientific+reports&rft.atitle=Profiling+of+the+Tox21+10K+compound+library+for+agonists+and+antagonists+of+the+estrogen+receptor+alpha+signaling+pathway.&rft.au=Huang%2C+Ruili%3BSakamuru%2C+Srilatha%3BMartin%2C+Matt+T%3BReif%2C+David+M%3BJudson%2C+Richard+S%3BHouck%2C+Keith+A%3BCasey%2C+Warren%3BHsieh%2C+Jui-Hua%3BShockley%2C+Keith+R%3BCeger%2C+Patricia%3BFostel%2C+Jennifer%3BWitt%2C+Kristine+L%3BTong%2C+Weida%3BRotroff%2C+Daniel+M%3BZhao%2C+Tongan%3BShinn%2C+Paul%3BSimeonov%2C+Anton%3BDix%2C+David+J%3BAustin%2C+Christopher+P%3BKavlock%2C+Robert+J%3BTice%2C+Raymond+R%3BXia%2C+Menghang&rft.aulast=Huang&rft.aufirst=Ruili&rft.date=2014-07-11&rft.volume=4&rft.issue=&rft.spage=5664&rft.isbn=&rft.btitle=&rft.title=Scientific+reports&rft.issn=2045-2322&rft_id=info:doi/10.1038%2Fsrep05664 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-10-28 N1 - Date created - 2014-07-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Sci. 2000 Mar;54(1):138-53 [10746941] Risk Anal. 2009 Apr;29(4):485-7; discussion 492-7 [19076321] Toxicol Sci. 2000 Sep;57(1):54-60 [10966511] Comb Chem High Throughput Screen. 2000 Oct;3(5):437-44 [11032959] Bioorg Med Chem Lett. 2001 Jul 23;11(14):1839-42 [11459643] Environ Health Perspect. 2002 Aug;110(8):743-8 [12153753] J Appl Toxicol. 2004 Jan-Feb;24(1):1-4 [14745840] J Med Food. 2003 Winter;6(4):387-90 [14977449] Maturitas. 2004 Apr 15;47(4):269-75 [15063479] J Reprod Dev. 2004 Apr;50(2):245-55 [15118252] Arch Environ Contam Toxicol. 2004 May;46(4):445-53 [15253041] Environ Health Perspect. 2004 Aug;112(12):1249-54 [15345371] Environ Health Perspect. 2009 May;117(5):685-95 [19479008] Endocrinology. 2010 Jan;151(1):32-42 [19906814] Annu Rev Physiol. 2010;72:247-72 [20148675] J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):343-8 [20156557] Crit Rev Toxicol. 2010 Nov;40 Suppl 3:1-30 [20932229] Chem Res Toxicol. 2011 Jan 14;24(1):6-19 [21053929] Toxicol Sci. 2011 Mar;120(1):42-58 [21163906] Sci Transl Med. 2011 Apr 27;3(80):80ps16 [21525397] Environ Health Perspect. 2011 Aug;119(8):1142-8 [21543282] Phytochemistry. 2011 Nov;72(16):2062-7 [21802698] J Steroid Biochem Mol Biol. 2012 Oct;132(1-2):186-93 [22634477] Mol Immunol. 2013 Apr;53(4):421-30 [23123408] ALTEX. 2013;30(1):51-6 [23338806] Chem Biol Interact. 2013 May 25;203(3):556-64 [23562765] Environ Health Perspect. 2013 Jul;121(7):756-65 [23603828] Drug Discov Today. 2013 Aug;18(15-16):716-23 [23732176] BMC Struct Biol. 2013;13:27 [24160181] Toxicology. 2004 Dec 1;205(1-2):113-22 [15458796] Science. 1984 Sep 7;225(4666):1032-4 [6474163] Ann N Y Acad Sci. 1995 Jun 12;761:355-60 [7625735] Environ Health Perspect. 1995 Oct;103 Suppl 7:113-22 [8593856] J Steroid Biochem Mol Biol. 1998 Dec;67(5-6):421-9 [10030691] J Mol Endocrinol. 2004 Oct;33(2):387-410 [15525597] Mol Cell. 2005 May 13;18(4):413-24 [15893725] Best Pract Res Clin Endocrinol Metab. 2006 Mar;20(1):15-33 [16522517] Chemosphere. 2006 Jun;64(1):174-7 [16337670] Hum Exp Toxicol. 2004 Nov;23(11):513-7 [15625776] Neural Netw. 2006 Jul-Aug;19(6-7):723-33 [16774731] Mol Aspects Med. 2006 Aug;27(4):299-402 [16914190] Biol Chem. 2006 Sep;387(9):1209-13 [16972788] Environ Toxicol Chem. 2007 Nov;26(11):2440-7 [17941737] Environ Health Perspect. 2007 Nov;115(11):1596-602 [18007991] J Appl Toxicol. 2008 Jan;28(1):78-91 [17992702] Science. 2008 Feb 15;319(5865):906-7 [18276874] Neuroscience. 2009 Jan 23;158(2):811-22 [19027052] In Vitr Mol Toxicol. 2000 Spring;13(1):67-82 [10900408] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/srep05664 ER - TY - JOUR T1 - Construction and analysis of a human hepatotoxicity database suitable for QSAR modeling using post-market safety data. AN - 1531952821; 24721472 AB - Drug-induced liver injury (DILI) is one of the most common drug-induced adverse events (AEs) leading to life-threatening conditions such as acute liver failure. It has also been recognized as the single most common cause of safety-related post-market withdrawals or warnings. Efforts to develop new predictive methods to assess the likelihood of a drug being a hepatotoxicant have been challenging due to the complexity and idiosyncrasy of clinical manifestations of DILI. The FDA adverse event reporting system (AERS) contains post-market data that depict the morbidity of AEs. Here, we developed a scalable approach to construct a hepatotoxicity database using post-market data for the purpose of quantitative structure-activity relationship (QSAR) modeling. A set of 2029 unique and modelable drug entities with 13,555 drug-AE combinations was extracted from the AERS database using 37 hepatotoxicity-related query preferred terms (PTs). In order to determine the optimal classification scheme to partition positive from negative drugs, a manually-curated DILI calibration set composed of 105 negatives and 177 positives was developed based on the published literature. The final classification scheme combines hepatotoxicity-related PT data with supporting information that optimize the predictive performance across the calibration set. Data for other toxicological endpoints related to liver injury such as liver enzyme abnormalities, cholestasis, and bile duct disorders, were also extracted and classified. Collectively, these datasets can be used to generate a battery of QSAR models that assess a drug's potential to cause DILI. Published by Elsevier Ireland Ltd. JF - Toxicology AU - Zhu, Xiao AU - Kruhlak, Naomi L AD - U.S. Food and Drug Administration, Center for Drug Evaluation and Research, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States. ; U.S. Food and Drug Administration, Center for Drug Evaluation and Research, 10903 New Hampshire Avenue, Silver Spring, MD 20993, United States. Electronic address: Naomi.Kruhlak@fda.hhs.gov. Y1 - 2014/07/03/ PY - 2014 DA - 2014 Jul 03 SP - 62 EP - 72 VL - 321 KW - Anti-Bacterial Agents KW - 0 KW - Anti-Inflammatory Agents, Non-Steroidal KW - Vitamins KW - Naproxen KW - 57Y76R9ATQ KW - Levofloxacin KW - 6GNT3Y5LMF KW - Ampicillin KW - 7C782967RD KW - Ascorbic Acid KW - PQ6CK8PD0R KW - Index Medicus KW - Post-market safety KW - Predictive toxicology KW - QSAR KW - Drug-induced liver injury KW - Animals KW - Liver -- pathology KW - Liver -- enzymology KW - Endpoint Determination KW - Bile Duct Diseases -- pathology KW - Humans KW - Vitamins -- toxicity KW - Levofloxacin -- toxicity KW - Algorithms KW - Calibration KW - Anti-Bacterial Agents -- toxicity KW - Naproxen -- toxicity KW - Anti-Inflammatory Agents, Non-Steroidal -- toxicity KW - Bile Duct Diseases -- chemically induced KW - Cholestasis -- chemically induced KW - Data Mining KW - Quantitative Structure-Activity Relationship KW - Cholestasis -- pathology KW - Product Surveillance, Postmarketing KW - Databases, Factual KW - Ampicillin -- toxicity KW - Ascorbic Acid -- toxicity KW - Drug Labeling KW - Chemical and Drug Induced Liver Injury -- classification KW - Chemical and Drug Induced Liver Injury -- pathology KW - Toxicity Tests -- statistics & numerical data KW - Chemical and Drug Induced Liver Injury -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1531952821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Construction+and+analysis+of+a+human+hepatotoxicity+database+suitable+for+QSAR+modeling+using+post-market+safety+data.&rft.au=Zhu%2C+Xiao%3BKruhlak%2C+Naomi+L&rft.aulast=Zhu&rft.aufirst=Xiao&rft.date=2014-07-03&rft.volume=321&rft.issue=&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2014.03.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-07-15 N1 - Date created - 2014-06-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2014.03.009 ER - TY - JOUR T1 - Using an Emergency Department Syndromic Surveillance System to investigate the impact of extreme cold weather events AN - 1684418385; 2011-750328 AB - This report describes the development of novel syndromic cold weather public health surveillance indicators for use in monitoring the impact of extreme cold weather on attendances at EDs, using data from the 2010-11 and 2011-12 winters. A number of new surveillance indicators were created specifically for the identification and monitoring of cold weather related ED attendances, using the diagnosis codes provided for each attendance in the Emergency Department Syndromic Surveillance System (EDSSS), the first national syndromic surveillance system of its kind in the UK. Using daily weather data for the local area, a time series analysis to test the sensitivity of each indicator to cold weather was undertaken. Diagnosis codes relating to a health outcome with a potential direct link to cold weather were identified and assigned to a number of 'cold weather surveillance indicators'. The time series analyses indicated strong correlations between low temperatures and cold indicators in nearly every case. The strongest fit with temperature was cold related fractures in females, and that of snowfall was cold related fractures in both sexes. Though currently limited to a small number of sentinel EDs, the EDSSS has the ability to give near real-time detail on the magnitude of the impact of weather events. EDSSS cold weather surveillance fits well with the aims of the Cold Weather Plan for England, providing information on those particularly vulnerable to cold related health outcomes severe enough to require emergency care. This timely information aids those responding to and managing the effects on human health, both within the EDs themselves and in the community as a whole. [Copyright Elsevier B.V.] JF - Public Health AU - Hughes, H E AU - Morbey, R AU - Hughes, T C AU - Locker, T E AU - Shannon, T AU - Carmichael, C AU - Murray, V AU - Ibbotson, S AU - Catchpole, M AU - McCloskey, B AU - Smith, G AU - Elliot, A J AD - Real-time Syndromic Surveillance Team, Public Health England, 6th Floor, 5 St Philip's Place, Birmingham B3 2PW, UK helen.hughes@phe.gov.uk Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 628 EP - 635 PB - Elsevier Ltd, The Netherlands VL - 128 IS - 7 SN - 0033-3506, 0033-3506 KW - Environment and environmental policy - Weather, climate, and natural disasters KW - Law and ethics - Criminal law KW - Government - Internal security KW - Health conditions and policy - Health and health policy KW - Syndromic surveillance Emergency department Injury Cold weather KW - Weather KW - England KW - Health policy KW - United Kingdom KW - Surveillance KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1684418385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health&rft.atitle=Using+an+Emergency+Department+Syndromic+Surveillance+System+to+investigate+the+impact+of+extreme+cold+weather+events&rft.au=Hughes%2C+H+E%3BMorbey%2C+R%3BHughes%2C+T+C%3BLocker%2C+T+E%3BShannon%2C+T%3BCarmichael%2C+C%3BMurray%2C+V%3BIbbotson%2C+S%3BCatchpole%2C+M%3BMcCloskey%2C+B%3BSmith%2C+G%3BElliot%2C+A+J&rft.aulast=Hughes&rft.aufirst=H&rft.date=2014-07-01&rft.volume=128&rft.issue=7&rft.spage=628&rft.isbn=&rft.btitle=&rft.title=Public+Health&rft.issn=00333506&rft_id=info:doi/10.1016%2Fj.puhe.2014.05.007 LA - English DB - PAIS Index N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Weather; Surveillance; England; Public health; Health policy; United Kingdom DO - http://dx.doi.org/10.1016/j.puhe.2014.05.007 ER - TY - JOUR T1 - The Influence of Age on Serum Concentrations of Cardiac Troponin I: Results in Rats, Monkeys, and Commercial Sera AN - 1683349576; PQ0001555038 AB - Cardiac troponins serve as serum biomarkers of myocardial injury. The current study examined the influence of age on serum concentrations of cardiac troponin I (cTnI). An ultrasensitive immunoassay was used to monitor cTnI concentrations in Sprague-Dawley (SD) rats and Erythrocebus patas monkeys of different ages. The mean cTnI concentrations were highest in 10-day-old rats compared to 25-, 40-, and 80-day-old SD rats. Cardiomyocyte remodeling was apparent in hearts from 10-day-old SD rats as evident by hypercellularity, irregularly shaped nuclei, and moderate numbers of myocytes undergoing mitosis and apoptosis. The mean concentration of cTnI in 5 newborn monkeys was considerably higher than that of three 1-year-old monkeys. Evidence of cardiomyocyte remodeling was also observed in these newborn hearts (loss of myofibrils and cytoplasmic vacuolation). Commercial animal serum samples were also analyzed. The concentrations of cTnI detected in fetal equine and porcine serum were considerably higher than that found in adult equine and porcine serum samples Likewise, fetal bovine serum had higher cTnI concentrations (>2,400 pg/ml) than did adult caprine and laprine samples (2.5-2.7 pg/ml). The present study found age-related differences in cTnI concentrations, with higher levels occurring at younger ages. This effect was consistent across several animal species. JF - Toxicologic Pathology AU - Herman, Eugene H AU - Knapton, Alan AU - Liu, Yongmin AU - Lipshultz, Steven E AU - Estis, Joel AU - Todd, John AU - Woodward, Ruth A AU - Cochran, Thomas AU - Zhang, Jun AU - Poirier, Miriam C AD - Food and Drug Administration, Division of Drug Safety Research, Silver Spring, Maryland, USA, eugene.herman@fda.hhs.gov Y1 - 2014/07// PY - 2014 DA - Jul 2014 SP - 888 EP - 896 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 42 IS - 5 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - cardiac troponin I KW - Sprague-Dawley rats KW - patas monkeys KW - young age. KW - Heart KW - Myocytes KW - Age KW - Apoptosis KW - Injuries KW - cardiomyocytes KW - biomarkers KW - Fetuses KW - Myofibrils KW - Mitosis KW - Erythrocebus patas KW - Neonates KW - Nuclei KW - Troponin I KW - Immunoassays KW - Calcium-binding protein KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683349576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=The+Influence+of+Age+on+Serum+Concentrations+of+Cardiac+Troponin+I%3A+Results+in+Rats%2C+Monkeys%2C+and+Commercial+Sera&rft.au=Herman%2C+Eugene+H%3BKnapton%2C+Alan%3BLiu%2C+Yongmin%3BLipshultz%2C+Steven+E%3BEstis%2C+Joel%3BTodd%2C+John%3BWoodward%2C+Ruth+A%3BCochran%2C+Thomas%3BZhang%2C+Jun%3BPoirier%2C+Miriam+C&rft.aulast=Herman&rft.aufirst=Eugene&rft.date=2014-07-01&rft.volume=42&rft.issue=5&rft.spage=888&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623313505154 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 39 N1 - Last updated - 2015-11-16 N1 - SubjectsTermNotLitGenreText - Heart; Age; Myocytes; Apoptosis; Injuries; cardiomyocytes; biomarkers; Fetuses; Myofibrils; Mitosis; Neonates; Troponin I; Nuclei; Immunoassays; Calcium-binding protein; Erythrocebus patas DO - http://dx.doi.org/10.1177/0192623313505154 ER - TY - JOUR T1 - Development of nutrition standards and therapeutic diet specifications for public hospitals in New South Wales AN - 1645091213; 24871049 AB - In New South Wales (NSW), a new suite of nutrition standards for menus and specifications for therapeutic diets to be used in hospitals has been developed. These standards were required to facilitate centralised menu planning and food production, with the move to management of most hospital food services by HealthShare NSW, a state-wide business unit of NSW Health. The standards also aim to improve communication between health professionals, particularly with the increasing use of computerised meal-ordering systems. Nutrition standards have been developed for adult, paediatric and mental health inpatients, and specifications for 147 different adult and paediatric therapeutic diets. There is still significant variation in the nutrition standards for nutrition and therapeutic diets in hospitals across the Australian states, and a move to a more nationally harmonised approach would be welcome. Further research is required to examine the impact of these standards on operating efficiency and patient care outcomes. JF - Australian Health Review AU - Williams, Peter, BSc, DipNutrDiet, MHP PhD, FDA AU - Hazlewood, Tanya, BSc, MSc(NutrDiet) AU - Pang, Glen, BSc, MNutrDiet Y1 - 2014 PY - 2014 DA - 2014 SP - 467 EP - 70 CY - Collingwood PB - CSIRO VL - 38 IS - 4 SN - 01565788 KW - Health Facilities And Administration KW - Studies KW - Hospitals KW - Nutrition KW - Diet KW - Standards KW - New South Wales Australia KW - 9130:Experiment/theoretical treatment KW - 8320:Health care industry KW - 9179:Asia & the Pacific UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1645091213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Australian+Health+Review&rft.atitle=Development+of+nutrition+standards+and+therapeutic+diet+specifications+for+public+hospitals+in+New+South+Wales&rft.au=Williams%2C+Peter%2C+BSc%2C+DipNutrDiet%2C+MHP+PhD%2C+FDA%3BHazlewood%2C+Tanya%2C+BSc%2C+MSc%28NutrDiet%29%3BPang%2C+Glen%2C+BSc%2C+MNutrDiet&rft.aulast=Williams&rft.aufirst=Peter&rft.date=2014-07-01&rft.volume=38&rft.issue=4&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Australian+Health+Review&rft.issn=01565788&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Australian Healthcare and Hospitals Association 2014 N1 - Document feature - References N1 - Last updated - 2016-04-16 N1 - SubjectsTermNotLitGenreText - New South Wales Australia ER - TY - JOUR T1 - Household and economic factors associated with geographic and school mobility among low- income children AN - 1642624668; 4630113 AB - Child poverty has been shown to have lifelong consequences, and several policy interventions have sought to alleviate its effects. However, federal school policy insufficiently addresses 'out of school' factors, including high rates of residential and school mobility among poor students. The detrimental effects of school mobility on achievement and classroom behavior have been well documented, but the literature on the household dynamics associated with residential and school mobility among the poor is limited. This study uses detailed administrative data from Oregon's Supplemental Nutrition Assistance Program to provide more information on residential and school mobility among low-income children of early elementary school age. Changes in household composition, income, employment, residential address, and school catchment were analyzed over several years to measure the relationship between mobility and household dynamics. We find that Oregon children from low-income families have high rates of residential and school mobility and that family dynamics rather than economic opportunity appear to increase the probability of moving. We offer several policy recommendations in light of the findings. Reprinted by permission of Carfax Publishing, Taylor and Francis Ltd JF - Journal of children and poverty AU - Porter, Suzanne AU - Edwards, Mark AD - US Department of Health and Human Services ; Oregon State University Y1 - 2014/07// PY - 2014 DA - Jul 2014 SP - 111 EP - 130 VL - 20 IS - 2 SN - 1079-6126, 1079-6126 KW - Sociology KW - U.S.A. KW - Oregon KW - Poverty KW - Residential mobility KW - Classrooms KW - Children KW - Primary schools KW - Low income UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1642624668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+children+and+poverty&rft.atitle=Household+and+economic+factors+associated+with+geographic+and+school+mobility+among+low-+income+children&rft.au=Porter%2C+Suzanne%3BEdwards%2C+Mark&rft.aulast=Porter&rft.aufirst=Suzanne&rft.date=2014-07-01&rft.volume=20&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Journal+of+children+and+poverty&rft.issn=10796126&rft_id=info:doi/10.1080%2F10796126.2014.979140 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2015-01-07 N1 - Last updated - 2015-01-07 N1 - SubjectsTermNotLitGenreText - 10948; 9962; 10141 11324; 2362 11324; 2212; 7553 6271; 314 433 293 14 DO - http://dx.doi.org/10.1080/10796126.2014.979140 ER - TY - JOUR T1 - BRDT gene sequence in human testicular pathologies and the implication of its single nucleotide polymorphism (rs3088232) on fertility AN - 1638223358 AB - Summary Bromodomain testis-specific (BRDT) protein is essential for the normal process of spermatogenesis. Mutant mice that expressed truncated BRDT had impaired testicular histology with severely reduced sperm concentration and abnormal sperm morphology, while a model of knockout Brdt mice with no BRDT protein had complete meiotic arrest. A BRDT single nucleotide polymorphism (SNP) (rs3088232) was reported as being associated with infertility in men. We assessed testicular specimens of 276 azoospermic men who underwent testicular sperm extraction to search for specimens that showed spermatogenic impairments similar to those of mutant BRDT mice. Ten similar specimens were selected for BRDT gene sequencing and they revealed three NCBI-reported SNPs (rs10783071, rs3088232 and rs10747493) variously distributed among them. Bioinformatics analysis predicted that they would not affect protein activity. Further assessment of rs3088232 frequency in a large group of non-obstructive azoospermia men and fertile controls demonstrated no significant difference between them (27.2 and 21.7% respectively; p = 0.122, Fisher's exact test). We conclude that the testicular impairments observed in the 10 specimens were not a consequence of BRDT gene mutation. The association between BRDT rs3088232 and infertility that had been reported in other studies was not supported. JF - Andrology AU - Barda, S AU - Yogev, L AU - Paz, G AU - Yavetz, H AU - Lehavi, O AU - Hauser, R AU - Doniger, T AU - Breitbart, H AU - Kleiman, S E Y1 - 2014/07// PY - 2014 DA - Jul 2014 SP - 641 EP - 647 CY - Hoboken PB - Wiley Subscription Services, Inc. VL - 2 IS - 4 SN - 20472919 KW - Medical Sciences--Urology And Nephrology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1638223358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Andrology&rft.atitle=BRDT+gene+sequence+in+human+testicular+pathologies+and+the+implication+of+its+single+nucleotide+polymorphism+%28rs3088232%29+on+fertility&rft.au=Barda%2C+S%3BYogev%2C+L%3BPaz%2C+G%3BYavetz%2C+H%3BLehavi%2C+O%3BHauser%2C+R%3BDoniger%2C+T%3BBreitbart%2C+H%3BKleiman%2C+S+E&rft.aulast=Barda&rft.aufirst=S&rft.date=2014-07-01&rft.volume=2&rft.issue=4&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Andrology&rft.issn=20472919&rft_id=info:doi/10.1111%2Fj.2047-2927.2014.00230.x LA - English DB - ProQuest Central N1 - Copyright - Andrology © 2014 American Society of Andrology and European Academy of Andrology N1 - Last updated - 2014-12-19 DO - http://dx.doi.org/10.1111/j.2047-2927.2014.00230.x ER - TY - JOUR T1 - Does Social Capital Protect Against the Adverse Behavioural Outcomes of Child Neglect? AN - 1627735339 AB - LONGSCAN was a longitudinal study of the risks and consequences of child abuse and neglect conducted between 1992 and 2012 among five sites across the US. Interviews with mothers of at-risk children began when the children were four years of age, and mothers and children from age six to age 18 years were interviewed every other year. Maltreatment reports were obtained from departments of social services, and subjects’ self-reported abuse was obtained at age 12. Generalised estimating equations were used to investigate the impact of informal social control, social cohesion and trust (SCT), and caregiver depression at ages 12, 14 and 16 years on externalising behaviours, smoking and alcohol use among 18-year olds who had been neglected prior to age 12. In models controlling for child age and gender, maltreatment types other than neglect, maternal education and study site, SCT significantly reduced the impact of caregiver depression on externalising behaviour and alcohol use among the neglected children at age 18. This moderating effect was not seen among non-neglected 18-year-old children. Copyright © 2014 John Wiley & Sons, Ltd. Key Practitioner Messages: * Child neglect is a significant predictor of adolescent health risk behaviours. * Caregiver depression increases the risk of neglect and increases the adverse behavioural outcomes of neglect. * Among children neglected before age 12, in the presence of caregiver depression, SCT reduce externalising behaviours and alcohol use at age 18. * Identification and treatment of caregiver depression, along with supporting community cohesion and neighbourhood trust, can ameliorate some of the negative outcomes associated with child neglect. ‘Child neglect is a significant predictor of adolescent health risk behaviours’ JF - Child Abuse Review AU - Kotch, Jonathan B AU - Smith, Jamie AU - Margolis, Benyamin AU - Black, Maureen M AU - English, Diana AU - Thompson, Richard AU - Lee, Li-Ching AU - Taneja, Gitanjali AU - Bangdiwala, Shrikant I AD - Department of Maternal and Child Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ; Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ; Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, Rockville, MD, USA. ; Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA. ; School of Social Work, University of Washington, Seattle, WA, USA. ; Juvenile Protective Association, Chicago, IL, USA. ; Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA. ; National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. ; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ; Department of Maternal and Child Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Y1 - 2014/07// PY - 2014 DA - Jul 2014 SP - 246 EP - 261 CY - Hoboken PB - Wiley Subscription Services, Inc. VL - 23 IS - 4 SN - 0952-9136 KW - Social Services And Welfare KW - Neglected children KW - Adolescents KW - Age KW - Alcohol related KW - Child abuse KW - Cohesion KW - Health behaviour KW - Identification KW - Maltreated children KW - Maltreatment KW - Mothers KW - Protective factors KW - Risk behaviour KW - Smoking KW - Social capital KW - Social cohesion KW - Social control KW - Social services KW - Depression KW - Child neglect KW - Child maltreatment KW - Carers KW - At risk KW - Alcohol consumption KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627735339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Abuse+Review&rft.atitle=Does+Social+Capital+Protect+Against+the+Adverse+Behavioural+Outcomes+of+Child+Neglect%3F&rft.au=Kotch%2C+Jonathan+B%3BSmith%2C+Jamie%3BMargolis%2C+Benyamin%3BBlack%2C+Maureen+M%3BEnglish%2C+Diana%3BThompson%2C+Richard%3BLee%2C+Li-Ching%3BTaneja%2C+Gitanjali%3BBangdiwala%2C+Shrikant+I&rft.aulast=Kotch&rft.aufirst=Jonathan&rft.date=2014-07-01&rft.volume=23&rft.issue=4&rft.spage=246&rft.isbn=&rft.btitle=&rft.title=Child+Abuse+Review&rft.issn=09529136&rft_id=info:doi/10.1002%2Fcar.2345 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA); Social Services Abstracts N1 - Date revised - 2014-11-10 N1 - Last updated - 2016-08-17 N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1002/car.2345 ER - TY - JOUR T1 - Psychometric Properties of the Dutch Version of the Self-Sufficiency Matrix (SSM-D) AN - 1567030813; 201433046 AB - Measuring treatment outcomes can be challenging in patients who experience multiple interlinked problems, as is the case in public mental health care (PMHC). This study describes the development and psychometric properties of a Dutch version of the self-sufficiency matrix (SSM-D), an instrument that measures outcomes and originates from the US. In two different settings, clients were rated using the SSM-D in combination with the Health of the Nation Outcome Scales (HoNOS) and the Camberwell assessment of need short appraisal schedule (CANSAS). The results provided support for adequate psychometric properties of the SSM-D. The SSM-D had a solid single factor structure and internal consistency of the scale was excellent. In addition, convergent validity of the SSM-D was indicated by strong correlations between HoNOS and CANSAS, as well as between several subdomains. Further research is needed to establish whether the results presented here can be obtained in other PMHC settings. Adapted from the source document. JF - Community Mental Health Journal AU - Fassaert, Thijs AU - Lauriks, Steve AU - Weerd, Stef AU - Theunissen, Jan AU - Kikkert, Martijn AU - Dekker, Jack AU - Buster, Marcel AU - Wit, Matty AD - Department of Epidemiology and Health Promotion, Public Health Service, Amsterdam, The Netherlands tfassaert@ggd.amsterdam.nl Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 583 EP - 590 PB - Springer, Dordrecht The Netherlands VL - 50 IS - 5 SN - 0010-3853, 0010-3853 KW - Clinical outcomes KW - Dutch version KW - Convergent validity KW - Selfsufficiency KW - Psychometric properties KW - Health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1567030813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Community+Mental+Health+Journal&rft.atitle=Psychometric+Properties+of+the+Dutch+Version+of+the+Self-Sufficiency+Matrix+%28SSM-D%29&rft.au=Fassaert%2C+Thijs%3BLauriks%2C+Steve%3BWeerd%2C+Stef%3BTheunissen%2C+Jan%3BKikkert%2C+Martijn%3BDekker%2C+Jack%3BBuster%2C+Marcel%3BWit%2C+Matty&rft.aulast=Fassaert&rft.aufirst=Thijs&rft.date=2014-07-01&rft.volume=50&rft.issue=5&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Community+Mental+Health+Journal&rft.issn=00103853&rft_id=info:doi/10.1007%2Fs10597-013-9683-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-10-01 N1 - Number of references - 37 N1 - Last updated - 2016-09-27 N1 - CODEN - CMHJAY N1 - SubjectsTermNotLitGenreText - Psychometric properties; Selfsufficiency; Dutch version; Clinical outcomes; Convergent validity; Health DO - http://dx.doi.org/10.1007/s10597-013-9683-6 ER - TY - JOUR T1 - A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the 'rule-of-two' model AN - 1554942562; 20482434 AB - Drug-induced liver injury (DILI) is a major cause of drug failures in both the preclinical and clinical phase. Consequently, improving prediction of DILI at an early stage of drug discovery will reduce the potential failures in the subsequent drug development program. In this regard, high-content screening (HCS) assays are considered as a promising strategy for the study of DILI; however, the predictive performance of HCS assays is frequently insufficient. In the present study, a new testing strategy was developed to improve DILI prediction by employing in vitro assays that was combined with the RO2 model (i.e., 'rule-of-two' defined by daily dose greater than or equal to 100 mg/day & logP greater than or equal to 3). The RO2 model was derived from the observation that high daily doses and lipophilicity of an oral medication were associated with significant DILI risk in humans. In the developed testing strategy, the RO2 model was used for the rational selection of candidates for HCS assays, and only the negatives predicted by the RO2 model were further investigated by HCS. Subsequently, the effects of drug treatment on cell loss, nuclear size, DNA damage/fragmentation, apoptosis, lysosomal mass, mitochondrial membrane potential, and steatosis were studied in cultures of primary rat hepatocytes. Using a set of 70 drugs with clear evidence of clinically relevant DILI, the testing strategy improved the accuracies by 10 % and reduced the number of drugs requiring experimental assessment by approximately 20 %, as compared to the HCS assay alone. Moreover, the testing strategy was further validated by including published data (Cosgrove et al. in Toxicol Appl Pharmacol 237:317-330, 2009) on drug-cytokine-induced hepatotoxicity, which improved the accuracies by 7 %. Taken collectively, the proposed testing strategy can significantly improve the prediction of in vitro assays for detecting DILI liability in an early drug discovery phase. JF - Archives of Toxicology AU - Chen, Minjun AU - Tung, Chun-Wei AU - Shi, Qiang AU - Guo, Lei AU - Shi, Leming AU - Fang, Hong AU - Borlak, Juergen AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA, weida.tong@fda.hhs.gov Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 1439 EP - 1449 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 88 IS - 7 SN - 0340-5761, 0340-5761 KW - Toxicology Abstracts KW - Data processing KW - Apoptosis KW - Injuries KW - Hepatocytes KW - steatosis KW - Animal models KW - Mitochondria KW - Cell culture KW - Drug development KW - Drug screening KW - hepatotoxicity KW - DNA damage KW - Drug discovery KW - Cell size KW - Liver KW - Drugs KW - Membrane potential KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1554942562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Toxicology&rft.atitle=A+testing+strategy+to+predict+risk+for+drug-induced+liver+injury+in+humans+using+high-content+screen+assays+and+the+%27rule-of-two%27+model&rft.au=Chen%2C+Minjun%3BTung%2C+Chun-Wei%3BShi%2C+Qiang%3BGuo%2C+Lei%3BShi%2C+Leming%3BFang%2C+Hong%3BBorlak%2C+Juergen%3BTong%2C+Weida&rft.aulast=Chen&rft.aufirst=Minjun&rft.date=2014-07-01&rft.volume=88&rft.issue=7&rft.spage=1439&rft.isbn=&rft.btitle=&rft.title=Archives+of+Toxicology&rft.issn=03405761&rft_id=info:doi/10.1007%2Fs00204-014-1276-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-08-01 N1 - Number of references - 37 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Apoptosis; Data processing; Injuries; Hepatocytes; steatosis; Animal models; Mitochondria; Drug development; Cell culture; Drug screening; hepatotoxicity; Drug discovery; DNA damage; Cell size; Liver; Drugs; Membrane potential DO - http://dx.doi.org/10.1007/s00204-014-1276-9 ER - TY - JOUR T1 - Functional Genomic Characterization of Virulence Factors from Necrotizing Fasciitis-Causing Strains of Aeromonas hydrophila AN - 1547867941; 20296357 AB - The genomes of 10 Aeromonas isolates identified and designated Aeromonas hydrophila WI, Riv3, and NF1 to NF4; A. dhakensis SSU; A. jandaei Riv2; and A. caviae NM22 and NM33 were sequenced and annotated. Isolates NF1 to NF4 were from a patient with necrotizing fasciitis (NF). Two environmental isolates (Riv2 and -3) were from the river water from which the NF patient acquired the infection. While isolates NF2 to NF4 were clonal, NF1 was genetically distinct. Outside the conserved core genomes of these 10 isolates, several unique genomic features were identified. The most virulent strains possessed one of the following four virulence factors or a combination of them: cytotoxic enterotoxin, exotoxin A, and type 3 and 6 secretion system effectors AexU and Hcp. In a septicemic-mouse model, SSU, NF1, and Riv2 were the most virulent, while NF2 was moderately virulent. These data correlated with high motility and biofilm formation by the former three isolates. Conversely, in a mouse model of intramuscular infection, NF2 was much more virulent than NF1. Isolates NF2, SSU, and Riv2 disseminated in high numbers from the muscular tissue to the visceral organs of mice, while NF1 reached the liver and spleen in relatively lower numbers on the basis of colony counting and tracking of bioluminescent strains in real time by in vivo imaging. Histopathologically, degeneration of myofibers with significant infiltration of polymorphonuclear cells due to the highly virulent strains was noted. Functional genomic analysis provided data that allowed us to correlate the highly infectious nature of Aeromonas pathotypes belonging to several different species with virulence signatures and their potential ability to cause NF. JF - Applied and Environmental Microbiology AU - Grim, Christopher J AU - Kozlova, Elena V AU - Ponnusamy, Duraisamy AU - Fitts, Eric C AU - Sha, Jian AU - Kirtley, Michelle L AU - van Lier, Christina J AU - Tiner, Bethany L AU - Erova, Tatiana E AU - Joseph, Sandeep J AD - Food and Drug Administration, Laurel, Maryland, USA, achopra@utmb.edu. Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 4162 EP - 4183 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 80 IS - 14 SN - 0099-2240, 0099-2240 KW - Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Genomes KW - Neurofibromin 2 KW - virulence factors KW - Leukocytes (polymorphonuclear) KW - Secretion KW - Animal models KW - Aeromonas hydrophila KW - Histopathology KW - Infection KW - exotoxin A KW - Virulence KW - Population genetics KW - Colonies KW - Necrotizing fasciitis KW - Degeneration KW - genomics KW - Biofilms KW - Rivers KW - Data processing KW - Bioluminescence KW - Spleen KW - Enumeration KW - Strains KW - imaging KW - Tracking KW - Cytotoxicity KW - Motility KW - Genomic analysis KW - Liver KW - Enterotoxins KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - Q1 08484:Species interactions: parasites and diseases KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1547867941?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Functional+Genomic+Characterization+of+Virulence+Factors+from+Necrotizing+Fasciitis-Causing+Strains+of+Aeromonas+hydrophila&rft.au=Grim%2C+Christopher+J%3BKozlova%2C+Elena+V%3BPonnusamy%2C+Duraisamy%3BFitts%2C+Eric+C%3BSha%2C+Jian%3BKirtley%2C+Michelle+L%3Bvan+Lier%2C+Christina+J%3BTiner%2C+Bethany+L%3BErova%2C+Tatiana+E%3BJoseph%2C+Sandeep+J&rft.aulast=Grim&rft.aufirst=Christopher&rft.date=2014-07-01&rft.volume=80&rft.issue=14&rft.spage=4162&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00486-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Number of references - 100 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Genomes; Virulence; Population genetics; Bioluminescence; Spleen; Histopathology; Biofilms; Strains; Tracking; Rivers; Neurofibromin 2; Data processing; virulence factors; Secretion; Leukocytes (polymorphonuclear); Animal models; Enumeration; Infection; imaging; exotoxin A; Motility; Colonies; Cytotoxicity; Necrotizing fasciitis; Genomic analysis; Liver; Degeneration; Enterotoxins; genomics; Aeromonas hydrophila DO - http://dx.doi.org/10.1128/AEM.00486-14 ER - TY - JOUR T1 - In Situ Evaluation of Paenibacillus alvei in Reducing Carriage of Salmonella enterica Serovar Newport on Whole Tomato Plants AN - 1547866206; 20207743 AB - Recently, tomatoes have been implicated as a primary vehicle in food-borne outbreaks of Salmonella enterica serovar Newport and other Salmonella serovars. Long-term intervention measures to reduce Salmonella prevalence on tomatoes remain elusive for growing and postharvest environments. A naturally occurring bacterium identified by 16S rRNA gene sequencing as Paenibacillus alvei was isolated epiphytically from plants native to the Virginia Eastern Shore tomato-growing region. After initial antimicrobial activity screening against Salmonella and 10 other bacterial pathogens associated with the human food supply, strain TS-15 was further used to challenge an attenuated strain of S. Newport on inoculated fruits, leaves, and blossoms of tomato plants in an insect-screened high tunnel with a split-plot design. Survival of Salmonella after inoculation was measured for groups with and those without the antagonist at days 0, 1, 2, and 3 and either day 5 for blossoms or day 6 for fruits and leaves. Strain TS-15 exhibited broad-range antimicrobial activity against both major food-borne pathogens and major bacterial phytopathogens of tomato. After P. alvei strain TS-15 was applied onto the fruits, leaves, and blossoms of tomato plants, the concentration of S. Newport declined significantly (P less than or equal to 0.05) compared with controls. Astonishingly, >90% of the plants had no detectable levels of Salmonella by day 5 for blossoms. The naturally occurring antagonist strain TS-15 is highly effective in reducing the carriage of Salmonella Newport on whole tomato plants. The application of P. alvei strain TS-15 is a promising approach for reducing the risk of Salmonella contamination during tomato production. JF - Applied and Environmental Microbiology AU - Allard, Sarah AU - Enurah, Alexander AU - Strain, Errol AU - Millner, Patricia AU - Rideout, Steven L AU - Brown, Eric W AU - Zheng, Jie AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA, JieZheng,jie.zheng{at}fda.hhs.gov. PY - 2014 SP - 3842 EP - 3849 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 80 IS - 13 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Fruits KW - Antimicrobial activity KW - Food KW - Leaves KW - Survival KW - Shores KW - Pathogens KW - Tunnels KW - Food contamination KW - Food plants KW - Paenibacillus alvei KW - Lycopersicon esculentum KW - Salmonella enterica KW - Inoculation KW - rRNA 16S KW - A 01330:Food Microbiology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1547866206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=In+Situ+Evaluation+of+Paenibacillus+alvei+in+Reducing+Carriage+of+Salmonella+enterica+Serovar+Newport+on+Whole+Tomato+Plants&rft.au=Allard%2C+Sarah%3BEnurah%2C+Alexander%3BStrain%2C+Errol%3BMillner%2C+Patricia%3BRideout%2C+Steven+L%3BBrown%2C+Eric+W%3BZheng%2C+Jie&rft.aulast=Allard&rft.aufirst=Sarah&rft.date=2014-07-01&rft.volume=80&rft.issue=13&rft.spage=3842&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.00835-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Number of references - 43 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Fruits; Antimicrobial activity; Food; Inoculation; Leaves; Shores; Survival; Pathogens; Food plants; Food contamination; Tunnels; rRNA 16S; Lycopersicon esculentum; Salmonella enterica; Paenibacillus alvei DO - http://dx.doi.org/10.1128/AEM.00835-14 ER - TY - JOUR T1 - Measurement Methods to Evaluate Engineered Nanomaterial Release from Food Contact Materials AN - 1547864571; 20166065 AB - This article is one of a series of 4 that report on a task of the NanoRelease Food Additive project of the Intl. Life Science Inst. Center for Risk Science Innovation and Application to identify, evaluate, and develop methods that are needed to confidently detect, characterize, and quantify intentionally produced engineered nanomaterials (ENMs) released from food along the alimentary tract. This particular article focuses on the problem of detecting ENMs that become released into food indirectly from food contact materials. In this review, an in-depth analysis of the release literature is presented and relevant release mechanisms are discussed. The literature review includes discussion of articles related to the release phenomenon in general, as experimental methods to detect ENMs migrating from plastic materials into other (nonfood) complex matrices were determined to be relevant to the focus problem of food safety. From the survey of the literature, several "control points" were identified where characterization data on ENMs and materials may be most valuable. The article concludes with a summary of findings and a discussion of potential knowledge gaps and targets for method development in this area. JF - Comprehensive Reviews in Food Science and Food Safety AU - Noonan, Gregory O AU - Whelton, Andrew J AU - Carlander, David AU - Duncan, Timothy V AD - Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, U.S.A. Y1 - 2014/07// PY - 2014 DA - Jul 2014 SP - 679 EP - 692 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 13 IS - 4 SN - 1541-4337, 1541-4337 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Food additives KW - Literature reviews KW - Reviews KW - Food contamination KW - Nanotechnology KW - Innovations KW - R2 23060:Medical and environmental health KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1547864571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Comprehensive+Reviews+in+Food+Science+and+Food+Safety&rft.atitle=Measurement+Methods+to+Evaluate+Engineered+Nanomaterial+Release+from+Food+Contact+Materials&rft.au=Noonan%2C+Gregory+O%3BWhelton%2C+Andrew+J%3BCarlander%2C+David%3BDuncan%2C+Timothy+V&rft.aulast=Noonan&rft.aufirst=Gregory&rft.date=2014-07-01&rft.volume=13&rft.issue=4&rft.spage=679&rft.isbn=&rft.btitle=&rft.title=Comprehensive+Reviews+in+Food+Science+and+Food+Safety&rft.issn=15414337&rft_id=info:doi/10.1111%2F1541-4337.12079 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2014-08-21 N1 - SubjectsTermNotLitGenreText - Food additives; Literature reviews; Reviews; Food contamination; Innovations; Nanotechnology DO - http://dx.doi.org/10.1111/1541-4337.12079 ER - TY - JOUR T1 - A dialyzer-based flow system for validating dynamic contrast enhanced MR image acquisition AN - 1544017130; 20146988 AB - Purpose Dynamic contrast enhanced magnetic resonance imaging (MRI) has proven to be quite sensitive for the characterization of masses and early response to therapy. However, it is fraught with a number of procedural challenges as well as a lack of standardization. In this article, we describe the use of a simple dialyzer-based flow system to evaluate reproducibility of dynamic contrast enhanced MRI under active flow conditions. Methods The MR signal during a bolus injection of Gd-DTPA was analyzed to test the precision and variability of contrast agent kinetics during a typical dynamic contrast enhanced MRI sequence. A simple model allows an estimation of the washout rate constant of Gd-DTPA through the polysulfone tubules of the dialyzer. Results The simple flow phantom described here provided reproducible measurements of the washout rate constants. The washout rate increased from 0.20 plus or minus 0.005 min super(-1) to 0.25 plus or minus 0.008 min super(-1) over 32 weeks. Measurements were also made at week 24 using dynamic computed tomography and found to be 0.27 plus or minus 0.006 min super(-1). Overall, the computed tomography derived rate constants results were found be 12% higher than the corresponding MRI values. Conclusion In this study, we show that a simple dialyzer-based flow phantom can be used for testing dynamic contrast enhanced MRI pulse sequences and also allows for short-term reproducibility testing of rate constants. Magn Reson Med 72:41-48, 2014. copyright 2013 Wiley Periodicals, Inc. JF - Magnetic Resonance in Medicine AU - Rajan, Sunder AU - Herbertson, Luke AU - Bernardo, Marcelino AU - Choyke, Peter AD - Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, FDA, Silver Spring, Maryland, USA. Y1 - 2014/07// PY - 2014 DA - Jul 2014 SP - 41 EP - 48 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 72 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Standardization KW - Kinetics KW - Magnetic resonance imaging KW - Computed tomography KW - Contrast media KW - N.M.R. KW - polysulfone KW - Dialyzers KW - Models KW - Tubules KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1544017130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=A+dialyzer-based+flow+system+for+validating+dynamic+contrast+enhanced+MR+image+acquisition&rft.au=Rajan%2C+Sunder%3BHerbertson%2C+Luke%3BBernardo%2C+Marcelino%3BChoyke%2C+Peter&rft.aulast=Rajan&rft.aufirst=Sunder&rft.date=2014-07-01&rft.volume=72&rft.issue=1&rft.spage=41&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.24887 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2014-07-24 N1 - SubjectsTermNotLitGenreText - Standardization; Kinetics; Computed tomography; Magnetic resonance imaging; Contrast media; N.M.R.; Tubules; Models; Dialyzers; polysulfone DO - http://dx.doi.org/10.1002/mrm.24887 ER - TY - JOUR T1 - Occupational fatalities among driver/sales workers and truck drivers in the United States, 2003-2008 AN - 1544006002; 20165822 AB - Background This study provides a national profile of occupational fatalities among truck drivers and driver-sales workers. Methods Data from the 2003-2008 Census of Fatal Occupational Injuries were used. Cases were extracted specifically for occupational subcategories included in the Driver/Sales Workers and Truck Drivers occupational category: Driver/Sales Workers, Heavy and Tractor-Trailer Truck Drivers, and Light Truck or Delivery Services Drivers. Results In 2003-2008, the group Driver/Sales Workers and Truck Drivers had 5,568 occupational fatalities, representing 17% of all occupational fatalities in the United States. The majority of these fatalities were in the subgroup Heavy and Tractor-Trailer Truck Drivers (85%) and due to transportation incidents (80%). Older and male drivers had higher fatality rates than their counterparts. Conclusions Findings suggest a need for targeted interventions to reduce highway fatalities among heavy truck drivers. Better employment data are needed to separate the three occupational subcategories by worker characteristic and employment history for use in research and prevention efforts. Am. J. Ind. Med. 57:800-809, 2014. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Chen, Guang X AU - Amandus, Harlan E AU - Wu, Nan AD - Division of Safety Research, National Institute for Occupational Safety and Health, Morgantown, West Virginia. Y1 - 2014/07// PY - 2014 DA - Jul 2014 SP - 800 EP - 809 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 7 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Historical account KW - Data processing KW - Injuries KW - Occupational safety KW - Intervention KW - Employment KW - Light effects KW - Workers KW - USA KW - Prevention KW - Transportation KW - Trucks KW - Census KW - Highways KW - Agricultural equipment KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1544006002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Occupational+fatalities+among+driver%2Fsales+workers+and+truck+drivers+in+the+United+States%2C+2003-2008&rft.au=Chen%2C+Guang+X%3BAmandus%2C+Harlan+E%3BWu%2C+Nan&rft.aulast=Chen&rft.aufirst=Guang&rft.date=2014-07-01&rft.volume=57&rft.issue=7&rft.spage=800&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22320 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Workers; Data processing; Injuries; Census; Light effects; Historical account; Mortality; Prevention; Transportation; Occupational safety; Intervention; Trucks; Employment; Highways; Agricultural equipment; USA DO - http://dx.doi.org/10.1002/ajim.22320 ER - TY - JOUR T1 - Toxicity of carboxylated carbon nanotubes in endothelial cells is attenuated by stimulation of the autophagic flux with the release of nanomaterial in autophagic vesicles. AN - 1542300151; 24566271 AB - Carbon nanotubes (CNTs) exhibit a number of unique properties that make them attractive for various nanomedicine applications including their intravascular use. Therefore, the vascular toxicity of CNTs is a critical safety concern and methods of CNTs toxicity modulation are of great interest. Here, we report that carboxylated multiwalled carbon nanotubes (MWCNTs) induce a decrease in viability of cultured human umbilical vein endothelial cells (HUVECs) associated with the profound accumulation of autophagosomes. This autophagosome accumulation was mTOR kinase independent and was caused by blockade of the autophagic flux rather than by activation of autophagy. Stimulation of the autophagic flux with 1nmol/L bafilomycin A1 attenuated the cytotoxicity of carboxylated MWCNTs in HUVECs and was associated with the extracellular release of the nanomaterial in autophagic microvesicles. Thus, pharmacological stimulation of the autophagic flux may represent a new method of cytoprotection against toxic effects of nanomaterials. This study investigates the mechanisms of toxicity of multiwalled carbon nanutubes on human endothelial cells, concluding that pharmacological stimulation of autophagic flux may represent a new method of cytoprotection against the toxic effects of these nanomaterials. Published by Elsevier Inc. JF - Nanomedicine : nanotechnology, biology, and medicine AU - Orecna, Martina AU - De Paoli, Silvia H AU - Janouskova, Olga AU - Tegegn, Tseday Z AU - Filipova, Marcela AU - Bonevich, John E AU - Holada, Karel AU - Simak, Jan AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA. ; Institute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague Czech Republic. ; Institute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. ; National Institute of Standards and Technology, Gaithersburg, MD, USA. ; Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD, USA. Electronic address: jan.simak@fda.hhs.gov. Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 939 EP - 948 VL - 10 IS - 5 KW - Macrolides KW - 0 KW - Nanotubes, Carbon KW - bafilomycin A1 KW - 88899-55-2 KW - Index Medicus KW - Carbon nanotubes KW - Bafilomycin A1 KW - Autophagy KW - Exocytosis KW - Microvesicles KW - Exocytosis -- drug effects KW - Macrolides -- pharmacology KW - Humans KW - Human Umbilical Vein Endothelial Cells KW - Autophagy -- physiology KW - Endothelial Cells -- drug effects KW - Nanostructures -- toxicity KW - Endothelial Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1542300151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanomedicine+%3A+nanotechnology%2C+biology%2C+and+medicine&rft.atitle=Toxicity+of+carboxylated+carbon+nanotubes+in+endothelial+cells+is+attenuated+by+stimulation+of+the+autophagic+flux+with+the+release+of+nanomaterial+in+autophagic+vesicles.&rft.au=Orecna%2C+Martina%3BDe+Paoli%2C+Silvia+H%3BJanouskova%2C+Olga%3BTegegn%2C+Tseday+Z%3BFilipova%2C+Marcela%3BBonevich%2C+John+E%3BHolada%2C+Karel%3BSimak%2C+Jan&rft.aulast=Orecna&rft.aufirst=Martina&rft.date=2014-07-01&rft.volume=10&rft.issue=5&rft.spage=939&rft.isbn=&rft.btitle=&rft.title=Nanomedicine+%3A+nanotechnology%2C+biology%2C+and+medicine&rft.issn=1549-9642&rft_id=info:doi/10.1016%2Fj.nano.2014.02.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-19 N1 - Date created - 2014-07-01 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.nano.2014.02.001 ER - TY - JOUR T1 - Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. AN - 1541381691; 24880342 AB - We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and 38,295 controls for follow-up. We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)). We also showed an association between common variation at 3q28 (TP63, rs13314271, OR = 1.13, P = 7.22 × 10(-10)) and lung adenocarcinoma that had been previously reported only in Asians. These findings provide further evidence for inherited genetic susceptibility to lung cancer and its biological basis. Additionally, our analysis demonstrates that imputation can identify rare disease-causing variants with substantive effects on cancer risk from preexisting genome-wide association study data. JF - Nature genetics AU - Wang, Yufei AU - McKay, James D AU - Rafnar, Thorunn AU - Wang, Zhaoming AU - Timofeeva, Maria N AU - Broderick, Peter AU - Zong, Xuchen AU - Laplana, Marina AU - Wei, Yongyue AU - Han, Younghun AU - Lloyd, Amy AU - Delahaye-Sourdeix, Manon AU - Chubb, Daniel AU - Gaborieau, Valerie AU - Wheeler, William AU - Chatterjee, Nilanjan AU - Thorleifsson, Gudmar AU - Sulem, Patrick AU - Liu, Geoffrey AU - Kaaks, Rudolf AU - Henrion, Marc AU - Kinnersley, Ben AU - Vallée, Maxime AU - LeCalvez-Kelm, Florence AU - Stevens, Victoria L AU - Gapstur, Susan M AU - Chen, Wei V AU - Zaridze, David AU - Szeszenia-Dabrowska, Neonilia AU - Lissowska, Jolanta AU - Rudnai, Peter AU - Fabianova, Eleonora AU - Mates, Dana AU - Bencko, Vladimir AU - Foretova, Lenka AU - Janout, Vladimir AU - Krokan, Hans E AU - Gabrielsen, Maiken Elvestad AU - Skorpen, Frank AU - Vatten, Lars AU - Njølstad, Inger AU - Chen, Chu AU - Goodman, Gary AU - Benhamou, Simone AU - Vooder, Tonu AU - Välk, Kristjan AU - Nelis, Mari AU - Metspalu, Andres AU - Lener, Marcin AU - Lubiński, Jan AU - Johansson, Mattias AU - Vineis, Paolo AU - Agudo, Antonio AU - Clavel-Chapelon, Francoise AU - Bueno-de-Mesquita, H Bas AU - Trichopoulos, Dimitrios AU - Khaw, Kay-Tee AU - Johansson, Mikael AU - Weiderpass, Elisabete AU - Tjønneland, Anne AU - Riboli, Elio AU - Lathrop, Mark AU - Scelo, Ghislaine AU - Albanes, Demetrius AU - Caporaso, Neil E AU - Ye, Yuanqing AU - Gu, Jian AU - Wu, Xifeng AU - Spitz, Margaret R AU - Dienemann, Hendrik AU - Rosenberger, Albert AU - Su, Li AU - Matakidou, Athena AU - Eisen, Timothy AU - Stefansson, Kari AU - Risch, Angela AU - Chanock, Stephen J AU - Christiani, David C AU - Hung, Rayjean J AU - Brennan, Paul AU - Landi, Maria Teresa AU - Houlston, Richard S AU - Amos, Christopher I AD - 1] Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK. [2]. ; 1] International Agency for Research on Cancer (IARC, World Health Organization (WHO)), Lyon, France. [2] [3]. ; deCODE Genetics, Amgen, Reykjavik, Iceland. ; Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA. ; International Agency for Research on Cancer (IARC, World Health Organization (WHO)), Lyon, France. ; Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK. ; Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. ; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany. ; Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA. ; Center for Genomic Medicine, Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA. ; Information Management Services, Inc., Rockville, Maryland, USA. ; Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada. ; 1] Division of Cancer Epidemiology, DKFZ, Heidelberg, Germany. [2] Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany. ; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA. ; Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ; Institute of Carcinogenesis, Russian N.N. Blokhin Cancer Research Centre, Moscow, Russia. ; Department of Epidemiology, Institute of Occupational Medicine, Lodz, Poland. ; The M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. ; National Institute of Environmental Health, Budapest, Hungary. ; Regional Authority of Public Health, Banská Bystrica, Slovak Republic. ; National Institute of Public Health, Bucharest, Romania. ; 1st Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University in Prague, Prague, Czech Republic. ; Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic. ; Palacky University, Olomouc, Czech Republic. ; Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway. ; Department of Laboratory Medicine, Children's and Women's Health, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. ; Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. ; Department of Community Medicine, University of Tromsø, Tromsø, Norway. ; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. ; INSERM U946, Paris, France. ; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. ; Department of Biomedicine, University of Bergen, Bergen, Norway. ; 1] Estonian Genome Center, Institute of Molecular and Cell Biology, Tartu, Estonia. [2] Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland. ; Estonian Genome Center, Institute of Molecular and Cell Biology, Tartu, Estonia. ; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. ; 1] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK. [2] Unit of Molecular and Genetic Epidemiology, HuGeF Foundation, Torino, Italy. ; Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology, Barcelona, Spain. ; 1] INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018, Nutrition, Hormones and Women's Health Team, Villejuif, France. [2] Université Paris Sud, UMRS 1018, Villejuif, France. [3] Institut Gustave Roussy, Villejuif, France. ; 1] Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK. [2] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. [3] Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands. ; 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. [2] Bureau of Epidemiologic Research, Academy of Athens, Athens, Greece. [3] Hellenic Health Foundation, Athens, Greece. ; University of Cambridge School of Clinical Medicine, Clinical Gerontology Unit, Addenbrooke's Hospital, Cambridge, UK. ; Department of Radiation Sciences, Umeå Universitet, Umeå, Sverige, Sweden. ; 1] Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. [2] Department of Research, Cancer Registry of Norway, Oslo, Norway. [3] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. [4] Samfundet Folkhälsan, Helsinki, Finland. ; Danish Cancer Society Research Center, Copenhagen, Denmark. ; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK. ; Centre d'Etude du Polymorphisme Humain (CEPH), Paris, France. ; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. ; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, USA. ; 1] Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany. [2] Department of Thoracic Surgery, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany. ; Department of Genetic Epidemiology, University of Göttingen, Göttingen, Germany. ; Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK. ; 1] Department of Oncology, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, UK. [2] Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK. ; 1] Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany. ; 1] Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), Bethesda, Maryland, USA. [2] [3]. ; 1] Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK. [2] [3]. ; 1] Center for Genomic Medicine, Department of Community and Family Medicine, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA. [2] [3]. Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 736 EP - 741 VL - 46 IS - 7 KW - BRCA2 Protein KW - 0 KW - BRCA2 protein, human KW - Checkpoint Kinase 2 KW - EC 2.7.1.11 KW - CHEK2 protein, human KW - EC 2.7.11.1 KW - Index Medicus KW - Risk Factors KW - Humans KW - Prognosis KW - Case-Control Studies KW - Genetic Predisposition to Disease KW - Meta-Analysis as Topic KW - Genome-Wide Association Study KW - Checkpoint Kinase 2 -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - BRCA2 Protein -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541381691?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+genetics&rft.atitle=Rare+variants+of+large+effect+in+BRCA2+and+CHEK2+affect+risk+of+lung+cancer.&rft.au=Wang%2C+Yufei%3BMcKay%2C+James+D%3BRafnar%2C+Thorunn%3BWang%2C+Zhaoming%3BTimofeeva%2C+Maria+N%3BBroderick%2C+Peter%3BZong%2C+Xuchen%3BLaplana%2C+Marina%3BWei%2C+Yongyue%3BHan%2C+Younghun%3BLloyd%2C+Amy%3BDelahaye-Sourdeix%2C+Manon%3BChubb%2C+Daniel%3BGaborieau%2C+Valerie%3BWheeler%2C+William%3BChatterjee%2C+Nilanjan%3BThorleifsson%2C+Gudmar%3BSulem%2C+Patrick%3BLiu%2C+Geoffrey%3BKaaks%2C+Rudolf%3BHenrion%2C+Marc%3BKinnersley%2C+Ben%3BVall%C3%A9e%2C+Maxime%3BLeCalvez-Kelm%2C+Florence%3BStevens%2C+Victoria+L%3BGapstur%2C+Susan+M%3BChen%2C+Wei+V%3BZaridze%2C+David%3BSzeszenia-Dabrowska%2C+Neonilia%3BLissowska%2C+Jolanta%3BRudnai%2C+Peter%3BFabianova%2C+Eleonora%3BMates%2C+Dana%3BBencko%2C+Vladimir%3BForetova%2C+Lenka%3BJanout%2C+Vladimir%3BKrokan%2C+Hans+E%3BGabrielsen%2C+Maiken+Elvestad%3BSkorpen%2C+Frank%3BVatten%2C+Lars%3BNj%C3%B8lstad%2C+Inger%3BChen%2C+Chu%3BGoodman%2C+Gary%3BBenhamou%2C+Simone%3BVooder%2C+Tonu%3BV%C3%A4lk%2C+Kristjan%3BNelis%2C+Mari%3BMetspalu%2C+Andres%3BLener%2C+Marcin%3BLubi%C5%84ski%2C+Jan%3BJohansson%2C+Mattias%3BVineis%2C+Paolo%3BAgudo%2C+Antonio%3BClavel-Chapelon%2C+Francoise%3BBueno-de-Mesquita%2C+H+Bas%3BTrichopoulos%2C+Dimitrios%3BKhaw%2C+Kay-Tee%3BJohansson%2C+Mikael%3BWeiderpass%2C+Elisabete%3BTj%C3%B8nneland%2C+Anne%3BRiboli%2C+Elio%3BLathrop%2C+Mark%3BScelo%2C+Ghislaine%3BAlbanes%2C+Demetrius%3BCaporaso%2C+Neil+E%3BYe%2C+Yuanqing%3BGu%2C+Jian%3BWu%2C+Xifeng%3BSpitz%2C+Margaret+R%3BDienemann%2C+Hendrik%3BRosenberger%2C+Albert%3BSu%2C+Li%3BMatakidou%2C+Athena%3BEisen%2C+Timothy%3BStefansson%2C+Kari%3BRisch%2C+Angela%3BChanock%2C+Stephen+J%3BChristiani%2C+David+C%3BHung%2C+Rayjean+J%3BBrennan%2C+Paul%3BLandi%2C+Maria+Teresa%3BHoulston%2C+Richard+S%3BAmos%2C+Christopher+I&rft.aulast=Wang&rft.aufirst=Yufei&rft.date=2014-07-01&rft.volume=46&rft.issue=7&rft.spage=736&rft.isbn=&rft.btitle=&rft.title=Nature+genetics&rft.issn=1546-1718&rft_id=info:doi/10.1038%2Fng.3002 LA - 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Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/ng.3002 ER - TY - JOUR T1 - Investigation of the effects of subchronic low dose oral exposure to bisphenol A (BPA) and ethinyl estradiol (EE) on estrogen receptor expression in the juvenile and adult female rat hypothalamus. AN - 1541380887; 24752507 AB - Concerns have been raised regarding the long-term impacts of early life exposure to the ubiquitous environmental contaminant bisphenol A (BPA) on brain organization. Because BPA has been reported to affect estrogen signaling, and steroid hormones play a critical role in brain sexual differentiation, there is also concern that BPA exposure could alter neural sex differences. Here, we examine the impact of subchronic exposure from gestation to adulthood to oral doses of BPA below the current no-observed-adverse-effect level (NOAEL) of 5 mg/kg body weight (bw)/day on estrogen receptor (ESR) expression in sexually dimorphic brain regions of prepubertal and adult female rats. The dams were gavaged daily with vehicle (0.3% carboxymethylcellulose), 2.5, 25, 260, or 2700 μg BPA/kg bw/day, or 0.5 or 5.0 μg ethinyl estradiol (EE)/kg bw/day from gestational day 6 until labor began. Offspring were then gavaged directly from the day after birth until the day before scheduled sacrifice on postnatal days 21 or 90. Using in situ hybridization, one or more BPA doses produced significant decreases in Esr1 expression in the juvenile female rat anteroventral periventricular nucleus (AVPV) of the hypothalamus and significant decreases in Esr2 expression in the adult female rat AVPV and medial preoptic area (MPOA), relative to vehicle controls. BPA did not simply reproduce EE effects, indicating that BPA is not acting solely as an estrogen mimic. The possible consequences of long-term changes in hypothalamic ESR expression resulting from subchronic low dose BPA exposure on neuroendocrine effects are discussed and being addressed in ongoing, related work. Published by Oxford University Press on behalf of Toxicological Sciences 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Rebuli, Meghan E AU - Cao, Jinyan AU - Sluzas, Emily AU - Delclos, K Barry AU - Camacho, Luísa AU - Lewis, Sherry M AU - Vanlandingham, Michelle M AU - Patisaul, Heather B AD - Department of Biology, North Carolina State University, Raleigh, North Carolina 27695 Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695. ; Department of Biology, North Carolina State University, Raleigh, North Carolina 27695. ; National Center for Toxicological Research, Jefferson, Arkansas 72079. ; Department of Biology, North Carolina State University, Raleigh, North Carolina 27695 Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695 Heather_Patisaul@ncsu.edu. Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 190 EP - 203 VL - 140 IS - 1 KW - Benzhydryl Compounds KW - 0 KW - Estrogen Receptor alpha KW - Estrogen Receptor beta KW - Phenols KW - Receptors, Estrogen KW - Ethinyl Estradiol KW - 423D2T571U KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - subchronic exposure KW - ethinyl estradiol KW - development KW - endocrine disruptor KW - hypothalamus KW - endocrine disruption KW - sexually dimorphic KW - brain KW - Gene Expression -- drug effects KW - Animals KW - Rats, Sprague-Dawley KW - Estrogen Receptor alpha -- genetics KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Male KW - Female KW - Pregnancy KW - Estrogen Receptor beta -- genetics KW - Benzhydryl Compounds -- toxicity KW - Aging -- metabolism KW - Receptors, Estrogen -- genetics KW - Prenatal Exposure Delayed Effects -- metabolism KW - Hypothalamus -- drug effects KW - Prenatal Exposure Delayed Effects -- chemically induced KW - Hypothalamus -- metabolism KW - Hypothalamus -- embryology KW - Phenols -- toxicity KW - Ethinyl Estradiol -- toxicity KW - Hypothalamus -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541380887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Investigation+of+the+effects+of+subchronic+low+dose+oral+exposure+to+bisphenol+A+%28BPA%29+and+ethinyl+estradiol+%28EE%29+on+estrogen+receptor+expression+in+the+juvenile+and+adult+female+rat+hypothalamus.&rft.au=Rebuli%2C+Meghan+E%3BCao%2C+Jinyan%3BSluzas%2C+Emily%3BDelclos%2C+K+Barry%3BCamacho%2C+Lu%C3%ADsa%3BLewis%2C+Sherry+M%3BVanlandingham%2C+Michelle+M%3BPatisaul%2C+Heather+B&rft.aulast=Rebuli&rft.aufirst=Meghan&rft.date=2014-07-01&rft.volume=140&rft.issue=1&rft.spage=190&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu074 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-19 N1 - Date created - 2014-06-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Endocrinology. 2004 Mar;145(3):1063-8 [14670982] Nat Neurosci. 2004 Oct;7(10):1034-9 [15452574] Mol Pharmacol. 1998 Jul;54(1):105-12 [9658195] Endocrinology. 1998 Oct;139(10):4252-63 [9751507] Front Neuroendocrinol. 1998 Oct;19(4):323-62 [9799588] Brain Res Mol Brain Res. 1999 Apr 6;67(1):165-71 [10101243] Environ Health Perspect. 1999 Feb;107 Suppl 1:89-108 [10229711] Front Neuroendocrinol. 2005 Apr;26(1):7-26 [15862182] Neurotoxicol Teratol. 2006 Jan-Feb;28(1):111-8 [16427766] Hum Reprod Update. 2006 Jul-Aug;12(4):341-9 [16672247] Endocrinology. 2006 Aug;147(8):3681-91 [16675520] Crit Rev Toxicol. 2006 May;36(5):387-457 [16954066] J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):175-9 [17088055] Toxicol Lett. 2006 Dec 1;167(2):95-105 [17049190] Int J Hyg Environ Health. 2011 Sep;214(5):339-47 [21570349] Toxicol Sci. 2011 Nov;124(1):149-60 [21813462] Chemosphere. 2011 Oct;85(6):943-7 [21741673] Toxicology. 2011 Dec 18;290(2-3):187-94 [21971502] Neurotoxicology. 2012 Jan;33(1):23-36 [22101008] Neurotoxicol Teratol. 2012 May-Jun;34(3):331-7 [22507915] Endocrinology. 2012 Aug;153(8):3828-38 [22707478] Reprod Domest Anim. 2012 Aug;47 Suppl 4:23-30 [22827346] PLoS One. 2012;7(9):e43890 [22957036] Food Chem Toxicol. 2012 Oct;50(10):3725-40 [22889897] Biol Reprod. 2012 Jun;87(6):129 [23034157] J Comp Neurol. 2013 Feb 1;521(2):465-78 [22791648] Toxicology. 2013 Feb 8;304:21-31 [23238275] Adv Exp Med Biol. 2013;784:455-79 [23550019] Toxicol Sci. 2013 May;133(1):157-73 [23457122] Food Chem Toxicol. 2013 Jul;57:284-95 [23567242] Neurotoxicology. 2013 May;36:55-62 [23500335] Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9956-61 [23716699] Reprod Toxicol. 2013 Sep;40:35-40 [23747832] Reprod Toxicol. 2013 Dec;42:132-55 [23994667] PLoS One. 2014;9(2):e88961 [24586459] Reproduction. 2014;147(4):537-54 [24352099] Gen Comp Endocrinol. 2007 Jan 15;150(2):298-308 [17097654] Neurotoxicology. 2007 Jan;28(1):1-12 [17109964] Neurotoxicol Teratol. 2007 Jan-Feb;29(1):108-15 [17157476] J Endocrinol. 2007 Jul;194(1):201-12 [17592034] Reprod Toxicol. 2007 Aug-Sep;24(2):199-224 [17683900] Best Pract Res Clin Endocrinol Metab. 2007 Sep;21(3):431-44 [17875490] J Biochem. 2007 Oct;142(4):517-24 [17761695] Physiol Rev. 2008 Jan;88(1):91-124 [18195084] Environ Health Perspect. 2008 Jan;116(1):39-44 [18197297] Brain Res Rev. 2008 Mar;57(2):277-87 [17604108] Endocr Dev. 2008;13:145-58 [18493139] J Steroid Biochem Mol Biol. 2008 Apr;109(3-5):300-6 [18430566] J Neuroendocrinol. 2008 Jun;20(6):873-9 [18601711] Birth Defects Res B Dev Reprod Toxicol. 2008 Jun;83(3):157-395 [18613034] NTP CERHR MON. 2008 Sep;(22):v, vii-ix, 1-64 passim [19407859] Biol Reprod. 2009 Nov;81(5):807-13 [19458313] Toxicol Sci. 2010 Mar;114(1):133-48 [19864446] Lab Anim (NY). 2010 May;39(5):149-54 [20410899] Front Neuroendocrinol. 2010 Jul;31(3):341-58 [20457175] Environ Health Perspect. 2010 Aug;118(8):1055-70 [20338858] Anal Bioanal Chem. 2010 Sep;398(1):571-6 [20623271] Trends Endocrinol Metab. 2010 Sep;21(9):553-61 [20813326] Curr Opin Neurobiol. 2010 Aug;20(4):424-31 [20471241] Reprod Toxicol. 2010 Dec;30(4):625-34 [20951796] Neurotoxicology. 2011 Jan;32(1):38-49 [20696184] Horm Behav. 2011 Mar;59(3):338-44 [20800064] Horm Behav. 2011 Mar;59(3):296-305 [21029734] Crit Rev Toxicol. 2011 Apr;41(4):263-91 [21438738] Reprod Toxicol. 2011 Apr;31(3):280-9 [20951797] J Comp Neurol. 2011 Oct 15;519(15):2954-77 [21484804] Toxicol Lett. 2014 Apr 7;226(1):81-9 [24495410] Toxicol Sci. 2014 May;139(1):174-97 [24496637] Toxicol Sci. 2014 May;139(1):4-20 [24496641] Toxicol Sci. 2014 Aug 1;140(2):374-92 [24798382] Horm Behav. 1994 Dec;28(4):483-91 [7729817] Prog Neuropsychopharmacol Biol Psychiatry. 1997 Nov;21(8):1185-201 [9460086] Reprod Toxicol. 2013 Dec;42:224-31 [24100206] PLoS One. 2014;9(1):e85894 [24465770] Brain Res Mol Brain Res. 2000 May 5;77(2):277-80 [10837923] Environ Health Perspect. 2000 Jun;108 Suppl 3:451-5 [10852844] Horm Behav. 2000 Aug;38(1):52-66 [10924287] Mech Dev. 2000 Oct;97(1-2):197-9 [11025225] Toxicol Sci. 2001 Jun;61(2):201-10 [11353128] Mech Ageing Dev. 2002 Mar 31;123(6):593-601 [11850023] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3306-11 [11854469] Environ Health Perspect. 2002 Apr;110(4):427-31 [11940462] Annu Rev Neurosci. 2002;25:507-36 [12052919] Endocrinology. 2003 Sep;144(9):4164-71 [12933691] J Comp Neurol. 2003 Nov 17;466(3):409-21 [14556297] Endocrinology. 2003 Nov;144(11):5098-104 [12960049] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu074 ER - TY - JOUR T1 - Expression kinetics of miRNA involved in dermal toluene 2,4-diisocyanate sensitization. AN - 1539470653; 24063594 AB - Allergic disease is an important occupational health concern, with work-related asthma and allergic contact dermatitis being the most frequently diagnosed occupational illnesses. Diisocyanates, particularly toluene 2,4-diisocyanate (TDI), have been the leading cause of occupational asthma for many years. Understanding the mechanisms behind allergic disease is critical for treatment and prevention. Recently, the study of post-transcriptional regulation by microRNAs (miRNA) has shed light on mechanisms of allergic disease. The present studies report the expression of miRNA during the sensitization phase of an allergic response to TDI in a murine model. Female BALB/c mice were dermally exposed to TDI (0.1-15% [v/v]) or vehicle. RNA was isolated from superficial parotid lymph nodes at timepoints between 1 h and 15 days post-exposure and then miRNA expression was analyzed using array and real-time quantitative PCR analysis. Consistent changes in miRNA expression were identified for miR-21, miR-22, miR-27b, miR-31, miR-126, miR-155, miR-210, and miR-301a. Following TDI exposure, peak expression was observed by Day 4 for the majority of miRNA evaluated with trends in expression correlated to exposure concentration. Confirmed and predicted targets were identified using Diana-microT, miRanda, miRwalk, and Targetscan algorithms. Evaluation of mRNA expression of cytokine and transcription factor targets suggests that miRNA may have a central role early in TDI sensitization. Understanding the role of these miRNA and their specific mechanism of action in sensitization to TDI may provide pertinent information for the identification of other chemical sensitizers while also contributing to the treatment and prevention of allergic disease. JF - Journal of immunotoxicology AU - Anderson, Stacey E AU - Beezhold, Kevin AU - Lukomska, Ewa AU - Richardson, Jodi AU - Long, Carrie AU - Anderson, Katie AU - Franko, Jennifer AU - Meade, B Jean AU - Beezhold, Donald H AD - National Institute for Occupational Safety and Health (NIOSH) , Morgantown, WV , USA and. PY - 2014 SP - 250 EP - 259 VL - 11 IS - 3 KW - Cytokines KW - 0 KW - Irritants KW - MicroRNAs KW - Transcription Factors KW - Toluene 2,4-Diisocyanate KW - 17X7AFZ1GH KW - Index Medicus KW - expression kinetics KW - miRNA KW - TDI chemical sensitization KW - Allergic disease KW - Animals KW - Administration, Cutaneous KW - Transcription Factors -- metabolism KW - Humans KW - Microarray Analysis KW - Disease Models, Animal KW - Mice KW - Cytokines -- metabolism KW - Mice, Inbred BALB C KW - Female KW - Irritants -- administration & dosage KW - Toluene 2,4-Diisocyanate -- administration & dosage KW - Lymph Nodes -- physiology KW - Asthma, Occupational -- genetics KW - Asthma, Occupational -- immunology KW - MicroRNAs -- analysis KW - Asthma, Occupational -- chemically induced KW - Lymph Nodes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1539470653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Expression+kinetics+of+miRNA+involved+in+dermal+toluene+2%2C4-diisocyanate+sensitization.&rft.au=Anderson%2C+Stacey+E%3BBeezhold%2C+Kevin%3BLukomska%2C+Ewa%3BRichardson%2C+Jodi%3BLong%2C+Carrie%3BAnderson%2C+Katie%3BFranko%2C+Jennifer%3BMeade%2C+B+Jean%3BBeezhold%2C+Donald+H&rft.aulast=Anderson&rft.aufirst=Stacey&rft.date=2014-07-01&rft.volume=11&rft.issue=3&rft.spage=250&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.3109%2F1547691X.2013.835891 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-16 N1 - Date created - 2014-06-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/1547691X.2013.835891 ER - TY - JOUR T1 - Evaluation of liquid and solid culture media for the recovery and enrichment of Burkholderia cenocepacia from distilled water. AN - 1534792490; 24756630 AB - Burkholderia cepacia complex (BCC) presence has been the cause of recalls of both sterile and non-sterile pharmaceutical products since these opportunistic pathogens have been implicated to cause infections to susceptible individuals. BCC are ubiquitous in nature, but in pharmaceutical settings the most common source is contaminated water systems. Some strains of BCC, previously described as Pseudomonas cepacia, were not readily detected by standard culture methods. We have explored different strategies to recover and enrich Burkholderia cenocepacia previously cultured in distilled water for 40 days. Enrichment media of varied nutrient concentrations and composition were used, including modified Tryptic Soy Agar or Broth (TSA or TSB), Reasoner's 2nd Agar or Broth (R2A or R2AB), Brain-Heart Infusion Broth (BHIB), Mueller-Hinton Broth (MHB), and Ashdown's (ASH) medium. Of the various broth media tested, cell growth was significantly greater in TSB and R2AB than in BHIB, MHB, or ASH broth. TSB and R2AB were also compared for their recovery efficiency. Generally, there was no significant difference between the numbers of B. cenocepacia grown on 15 differently modified TSA and five modified R2A solid media. Overall, however, diluted TSA and TSB media, and R2A and R2AB showed better recovery efficiency than TSA and TSB for inocula containing small numbers of cells. All strains persisted in distilled water for 40 days. Broth media were more effective than solid media for recovery of B. cenocepacia from distilled water. These results may assist in improving detection assays with recovery and enrichment strategies to maximize recovery of these fastidious organisms. JF - Journal of industrial microbiology & biotechnology AU - Ahn, Youngbeom AU - Kim, Jeong Myeong AU - Ahn, Hyeri AU - Lee, Yong-Jin AU - LiPuma, John J AU - Hussong, David AU - Cerniglia, Carl E AD - National Center for Toxicological Research, Division of Microbiology, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079-9502, USA, young.ahn@fda.hhs.gov. Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 1109 EP - 1118 VL - 41 IS - 7 KW - Culture Media KW - 0 KW - Water KW - 059QF0KO0R KW - Agar KW - 9002-18-0 KW - Index Medicus KW - Drug Industry KW - Bacterial Load -- drug effects KW - Microbial Viability -- drug effects KW - Burkholderia cenocepacia -- growth & development KW - Burkholderia cenocepacia -- isolation & purification KW - Water -- chemistry KW - Burkholderia cenocepacia -- drug effects KW - Water Microbiology KW - Culture Media -- pharmacology KW - Culture Media -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534792490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+industrial+microbiology+%26+biotechnology&rft.atitle=Evaluation+of+liquid+and+solid+culture+media+for+the+recovery+and+enrichment+of+Burkholderia+cenocepacia+from+distilled+water.&rft.au=Ahn%2C+Youngbeom%3BKim%2C+Jeong+Myeong%3BAhn%2C+Hyeri%3BLee%2C+Yong-Jin%3BLiPuma%2C+John+J%3BHussong%2C+David%3BCerniglia%2C+Carl+E&rft.aulast=Ahn&rft.aufirst=Youngbeom&rft.date=2014-07-01&rft.volume=41&rft.issue=7&rft.spage=1109&rft.isbn=&rft.btitle=&rft.title=Journal+of+industrial+microbiology+%26+biotechnology&rft.issn=1476-5535&rft_id=info:doi/10.1007%2Fs10295-014-1442-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-15 N1 - Date created - 2014-06-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s10295-014-1442-3 ER - TY - JOUR T1 - Working conditions and health in Central America: a survey of 12,024 workers in six countries. AN - 1534790812; 24652231 AB - To describe the survey methodology and initial general findings of the first Central American Survey of Working Conditions and Health. A representative sample of 12,024 workers was interviewed at home in Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua and Panama. Questionnaire items addressed worker demographics, employment conditions, occupational risk factors and self-perceived health. Overall, self-employment (37%) is the most frequent type of employment, 8% of employees lack a work contract and 74% of the workforce is not covered by social security. These percentages are higher in Guatemala, Honduras and El Salvador, and lower in Costa Rica, Panama and Nicaragua. A third of the workforce works more than 48 h per week, regardless of gender; this is similar across countries. Women and men report frequent or usual exposures to high ambient temperature (16% and 25%, respectively), dangerous tools and machinery (10%, 24%), work on slippery surfaces (10%, 23%), breathing chemicals (12.1%, 18%), handling toxic substances (5%, 12.1%), heavy loads (6%, 20%) and repetitive movements (43%, 49%). Two-thirds of the workforce perceive their health as being good or very good, and slightly more than half reports having good mental health. The survey offers, for the first time, comparable data on the work and health status of workers in the formal and informal economy in the six Spanish-speaking Central American countries, based on representative national samples. This provides a benchmark for future monitoring of employment and working conditions across countries. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. JF - Occupational and environmental medicine AU - Benavides, Fernando G AU - Wesseling, Catharina AU - Delclos, George L AU - Felknor, Sarah AU - Pinilla, Javier AU - Rodrigo, Fernando AU - research team of the first Central American Survey of Working Conditions and Health AD - Centro de Investigación en Salud Laboral (CISAL), Universitat Pompeu Fabra, Barcelona, Spain CIBER of Epidemiology and Public Health, Spain IMIM Parc Salut Mar., Barcelona, Spain. ; Programa Salud, Trabajo y Ambiente en América Central (SALTRA), Central American Institute for Studies on Toxic Substances, Universidad Nacional, Heredia, Costa Rica. ; The University of Texas School of Public Health (UT), Houston, USA Centro de Investigación en Salud Laboral (CISAL), Universitat Pompeu Fabra, Barcelona, Spain CIBER of Epidemiology and Public Health, Spain IMIM Parc Salut Mar., Barcelona, Spain. ; The University of Texas School of Public Health (UT), Houston, USA National Institute for Occupational Safety and Health (NIOSH), Atlanta, USA. ; Instituto Nacional de Seguridad e Higiene en el Trabajo (INSHT). Ministerio de Empleo y Seguridad Social, Madrid, Spain. ; Centro de Investigación en Salud Laboral (CISAL), Universitat Pompeu Fabra, Barcelona, Spain Instituto Sindical Trabajo, Ambiente y Salud (ISTAS), CCOO, Valencia, Spain. ; research team of the first Central American Survey of Working Conditions and Health Y1 - 2014/07// PY - 2014 DA - July 2014 SP - 459 EP - 465 VL - 71 IS - 7 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Workload KW - Contracts KW - Humans KW - Social Security KW - Hot Temperature KW - Stress, Mechanical KW - Adult KW - Surveys and Questionnaires KW - Interviews as Topic KW - Middle Aged KW - Data Collection KW - Accidents, Occupational KW - Central America KW - Female KW - Male KW - Surface Properties KW - Cumulative Trauma Disorders KW - Occupational Exposure KW - Health KW - Developing Countries KW - Employment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534790812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Working+conditions+and+health+in+Central+America%3A+a+survey+of+12%2C024+workers+in+six+countries.&rft.au=Benavides%2C+Fernando+G%3BWesseling%2C+Catharina%3BDelclos%2C+George+L%3BFelknor%2C+Sarah%3BPinilla%2C+Javier%3BRodrigo%2C+Fernando%3Bresearch+team+of+the+first+Central+American+Survey+of+Working+Conditions+and+Health&rft.aulast=Benavides&rft.aufirst=Fernando&rft.date=2014-07-01&rft.volume=71&rft.issue=7&rft.spage=459&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/10.1136%2Foemed-2013-101908 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-07-28 N1 - Date created - 2014-06-10 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: Occup Environ Med. 2014 Jul;71(7):457-8 [24816516] Occup Environ Med. 2015 Mar;72(3):236 [25431434] Occup Environ Med. 2015 Mar;72(3):236-7 [25431435] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/oemed-2013-101908 ER - TY - JOUR T1 - Tracking and modeling norovirus transmission during mechanical slicing of globe tomatoes AN - 1560112652; 20558073 AB - Recent epidemiological evidence indicates that preparation of fresh produce for use as ingredients in ready-to-eat food in commercial settings has been a significant source of the norovirus (NoV) infections in the U.S. This research investigated the dissemination of NoV from a single tomato to many others via the use of an 11-horizontal blade slicer commonly found in restaurants or sandwich shops. A total of eight trials were conducted. The source of contamination in each trial was a soak-inoculated, air-dried globe tomato containing -8 log10 murine norovirus (MNV). Each trial began by slicing a single un-inoculated tomato in the slicer, followed by slicing an inoculated tomato. This was then followed by slicing 9 to 27 un-inoculated tomatoes. A similar and constant hand pressure on the slicer was used in every trial. Three slices from each tomato were collected for virus elution, concentration, and extraction before RT-PCR detection of MNV. The change in MNV per sliced tomato was averaged over all eight trials, and two mathematical models were fit to the average data using a logarithmic model or a power model. Regression analysis determined that the equation that best fit the data was y = -0.903 times ln(x) + 7.945, where y = log10 MNV per slicing and x = tomato slicing number. An acceptable fit (R super(2) = 0.913) was indicated. The MNV levels transferred (y) generally decreased as the number of tomatoes sliced (x) increased, with some exceptions. Infrequent but erratic transfers, where the MNV level of a subsequent tomato was higher than that of a preceding tomato, occurred in later transfer of some trials. In contrast, the first and second transfers of each trial were always shown to have sharply decreased levels of MNV from the inoculum. The MNV log10 reduction per slicing event changes throughout the process: with a predicted 0.63 log10 reduction from tomato 1 to tomato 2 (76% reduction); a 0.07 log10 reduction predicted from tomato 13 to tomato 14 (a 14% reduction); and 0.03 log10 reduction predicted from tomato 27 to tomato 28 (a 7% reduction). Virus transfer is clearly variable even given the consistent slicing procedure used throughout each trial. This study illustrates the complex nature of risk prediction associated with NoV cross-contamination during food preparation in commercial establishments. JF - International Journal of Food Microbiology AU - Shieh, Y Carol AU - Tortorello, Mary Lou AU - Fleischman, Gregory J AU - Li, Di AU - Schaffner, Donald W AD - US Food and Drug Administration, Division of Food Processing Science and Technology, Bedford Park, IL 60501, United States, carol.shieh@fda.hhs.gov Y1 - 2014/06/16/ PY - 2014 DA - 2014 Jun 16 SP - 13 EP - 18 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 180 SN - 0168-1605, 0168-1605 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Norovirus KW - Tomato KW - Mechanical slicing KW - Modeling KW - Transmission KW - Mathematical models KW - Data processing KW - Food KW - Animal models KW - Hand KW - Infection KW - Food contamination KW - Lycopersicon esculentum KW - Inoculum KW - Regression analysis KW - Polymerase chain reaction KW - Pressure KW - V 22420:Plant Diseases KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560112652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Food+Microbiology&rft.atitle=Tracking+and+modeling+norovirus+transmission+during+mechanical+slicing+of+globe+tomatoes&rft.au=Shieh%2C+Y+Carol%3BTortorello%2C+Mary+Lou%3BFleischman%2C+Gregory+J%3BLi%2C+Di%3BSchaffner%2C+Donald+W&rft.aulast=Shieh&rft.aufirst=Y&rft.date=2014-06-16&rft.volume=180&rft.issue=&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Food+Microbiology&rft.issn=01681605&rft_id=info:doi/10.1016%2Fj.ijfoodmicro.2014.04.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Data processing; Mathematical models; Food; Regression analysis; Inoculum; Animal models; Polymerase chain reaction; Hand; Pressure; Food contamination; Infection; Lycopersicon esculentum; Norovirus DO - http://dx.doi.org/10.1016/j.ijfoodmicro.2014.04.002 ER - TY - CPAPER T1 - What Are Other Countries Doing on Aquaculture Farms to Ensure Their Products Are Safe and Consistently High Quality....and Protecting Their Industry and Market Share? T2 - 2014 World Aquaculture Society Meeting (WAA14) AN - 1553311867; 6301185 JF - 2014 World Aquaculture Society Meeting (WAA14) AU - Koonse, Brett Y1 - 2014/06/07/ PY - 2014 DA - 2014 Jun 07 KW - Farms KW - Industrial products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1553311867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+World+Aquaculture+Society+Meeting+%28WAA14%29&rft.atitle=What+Are+Other+Countries+Doing+on+Aquaculture+Farms+to+Ensure+Their+Products+Are+Safe+and+Consistently+High+Quality....and+Protecting+Their+Industry+and+Market+Share%3F&rft.au=Koonse%2C+Brett&rft.aulast=Koonse&rft.aufirst=Brett&rft.date=2014-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+World+Aquaculture+Society+Meeting+%28WAA14%29&rft.issn=&rft_id=info:doi/ L2 - https://www.was.org/meetings/SessionsByDay.aspx?Code=WA2014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-31 N1 - Last updated - 2014-08-15 ER - TY - CPAPER T1 - Good Aquaculture Practices to Reduce the Use of Chemotherapeutic Agents and Control Product Quality T2 - 2014 World Aquaculture Society Meeting (WAA14) AN - 1553311529; 6301482 JF - 2014 World Aquaculture Society Meeting (WAA14) AU - Serfling, Stanley Y1 - 2014/06/07/ PY - 2014 DA - 2014 Jun 07 KW - Chemotherapy KW - Aquaculture practices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1553311529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+World+Aquaculture+Society+Meeting+%28WAA14%29&rft.atitle=Good+Aquaculture+Practices+to+Reduce+the+Use+of+Chemotherapeutic+Agents+and+Control+Product+Quality&rft.au=Serfling%2C+Stanley&rft.aulast=Serfling&rft.aufirst=Stanley&rft.date=2014-06-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+World+Aquaculture+Society+Meeting+%28WAA14%29&rft.issn=&rft_id=info:doi/ L2 - https://www.was.org/meetings/SessionsByDay.aspx?Code=WA2014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-31 N1 - Last updated - 2014-08-15 ER - TY - RPRT T1 - Smokeless Tobacco Use Among Working Adults - United States, 2005 and 2010 AN - 1537948766; 24898164 AB - Mazurek et al present a report that describes the results of CDC analysis if National Health Interview Survey data to estimate the proportion of US working adults who used smokeless tobacco in 2005 and 2010, by industry and occupation. The analysis showed no statistically significant change in the prevalence of smokeless tobacco use among workers from 2005 (2.7%) to 2010 (3.0%). The findings highlight opportunities in reducing the health and economic burdens of tobacco use among US workers, especially those in certain industries where use of smokeless tobacco is especially common. CDC recommends best practices for comprehensive tobacco control programs, including effective employer interventions, such as providing employee health insurance coverage for proven cessation treatments, offering easily accessible help for those who want to quit, and establishing and enforcing tobacco-free workplace policies. JF - MMWR. Morbidity and Mortality Weekly Report AU - Mazurek, Jacek M, MD AU - Syamlal, Girija, MPH AU - King, Brian A, PhD AU - Castellan, Robert M, MD Y1 - 2014/06/06/ PY - 2014 DA - 2014 Jun 06 SP - 477 EP - 82 CY - Atlanta PB - U.S. Center for Disease Control KW - Public Health And Safety KW - Medical statistics KW - Public health KW - Smoking KW - Tobacco KW - Workers KW - United States--US KW - Young Adult KW - Humans KW - Adult KW - Aged KW - Occupations -- statistics & numerical data KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Employment -- statistics & numerical data KW - Tobacco, Smokeless -- utilization KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1537948766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.atitle=Smokeless+Tobacco+Use+Among+Working+Adults+-+United+States%2C+2005+and+2010&rft.au=Mazurek%2C+Jacek+M%2C+MD%3BSyamlal%2C+Girija%2C+MPH%3BKing%2C+Brian+A%2C+PhD%3BCastellan%2C+Robert+M%2C+MD&rft.aulast=Mazurek&rft.aufirst=Jacek&rft.date=2014-06-06&rft.volume=63&rft.issue=22&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.issn=01492195&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Center for Disease Control Jun 6, 2014 N1 - Document feature - Tables; References N1 - Last updated - 2014-07-31 ER - TY - JOUR T1 - Residential Levels of Polybrominated Diphenyl Ethers and Risk of Childhood Acute Lymphoblastic Leukemia in California AN - 1622604891; 20889827 AB - Background: House dust is a major source of exposure to polybrominated diphenyl ethers (PBDEs), which are found at high levels in U.S. homes. Methods: We studied 167 acute lymphoblastic leukemia (ALL) cases 0-7 years of age and 214 birth certificate controls matched on date of birth, sex, and race/ethnicity from the Northern California Childhood Leukemia Study. In 2001-2007, we sampled carpets in the room where the child spent the most time while awake; we used a high-volume small-surface sampler or we took dust from the home vacuum. We measured concentrations of 14 PBDE congeners including penta (28, 47, 99, 100, 153, 154), octa (183, 196, 197, 203), and decaBDEs (206-209). Odds ratios (ORs) were calculated using logistic regression, adjusting for demographics, income, year of dust collection, and sampling method. Results: BDE-47, BDE-99, and BDE-209 were found at the highest concentrations (medians, 1,173, 1,579, and 938 ng/g, respectively). Comparing the highest to lowest quartile, we found no association with ALL for summed pentaBDEs (OR = 0.7; 95% CI: 0.4, 1.3), octaBDEs (OR = 1.3; 95% CI: 0.7, 2.3), or decaBDEs (OR = 1.0; 95% CI: 0.6, 1.8). Comparing homes in the highest concentration (nanograms per gram) tertile to those with no detections, we observed significantly increased ALL risk for BDE-196 (OR = 2.1; 95% CI: 1.1, 3.8), BDE-203 (OR = 2.0; 95% CI: 1.1, 3.6), BDE-206 (OR = 2.1; 95% CI: 1.1, 3.9), and BDE-207 (OR = 2.0; 95% CI: 1.03, 3.8). Conclusion: We found no association with ALL for common PBDEs, but we observed positive associations for specific octa and nonaBDEs. Additional studies with repeated sampling and biological measures would be informative. Citation: Ward MH, Colt JS, Deziel NC, Whitehead TP, Reynolds P, Gunier RB, Nishioka M, Dahl GV, Rappaport SM, Buffler PA, Metayer C. 2014. Residential levels of polybrominated diphenyl ethers and risk of childhood acute lymphoblastic leukemia in California. Environ Health Perspect 122:1110-1116; http://dx.doi.org/10.1289/ehp.1307602 JF - Environmental Health Perspectives AU - Ward, Mary H AU - Colt, Joanne S AU - Deziel, Nicole C AU - Whitehead, Todd P AU - Reynolds, Peggy AU - Gunier, Robert B AU - Nishioka, Marcia AU - Dahl, Gary V AU - Rappaport, Stephen M AU - Buffler, Patricia A AU - Metayer, Catherine AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2014/06/03/ PY - 2014 DA - 2014 Jun 03 SP - 1110 EP - 1116 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 122 IS - 10 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Retinoblastoma protein KW - Dust KW - Income KW - Polybrominated diphenyl ethers KW - Demography KW - Leukemia KW - Carpets KW - Acute lymphatic leukemia KW - Congeners KW - USA, California KW - Sampling KW - Ethnic groups KW - Races KW - Sex KW - Vacuum KW - Children KW - Samplers KW - Birth KW - polybrominated diphenyl ethers KW - House dust KW - Sampling methods KW - H 12000:Epidemiology and Public Health KW - R2 23060:Medical and environmental health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622604891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Residential+Levels+of+Polybrominated+Diphenyl+Ethers+and+Risk+of+Childhood+Acute+Lymphoblastic+Leukemia+in+California&rft.au=Ward%2C+Mary+H%3BColt%2C+Joanne+S%3BDeziel%2C+Nicole+C%3BWhitehead%2C+Todd+P%3BReynolds%2C+Peggy%3BGunier%2C+Robert+B%3BNishioka%2C+Marcia%3BDahl%2C+Gary+V%3BRappaport%2C+Stephen+M%3BBuffler%2C+Patricia+A%3BMetayer%2C+Catherine&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2014-06-03&rft.volume=122&rft.issue=10&rft.spage=1110&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1307602 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Retinoblastoma protein; Vacuum; Children; Samplers; Dust; Birth; Demography; polybrominated diphenyl ethers; House dust; Carpets; Acute lymphatic leukemia; Congeners; Sampling; Races; Ethnic groups; Sex; Polybrominated diphenyl ethers; Leukemia; Age; Sampling methods; Income; USA, California DO - http://dx.doi.org/10.1289/ehp.1307602 ER - TY - JOUR T1 - Inference of strata separation and gas emission paths in longwall overburden using continuous wavelet transform of well logs and geostatistical simulation AN - 1855318055; 2017-000182 AB - Prediction of potential methane emission pathways from various sources into active mine workings or sealed gobs from longwall overburden is important for controlling methane and for improving mining safety. The aim of this paper is to infer strata separation intervals and thus gas emission pathways from standard well log data. The proposed technique was applied to well logs acquired through the Mary Lee/Blue Creek coal seam of the Upper Pottsville Formation in the Black Warrior Basin, Alabama, using well logs from a series of boreholes aligned along a nearly linear profile. For this purpose, continuous wavelet transform (CWT) of digitized gamma well logs was performed by using Mexican hat and Morlet, as the mother wavelets, to identify potential discontinuities in the signal. Pointwise Holder exponents (PHE) of gamma logs were also computed using the generalized quadratic variations (GQV) method to identify the location and strength of singularities of well log signals as a complementary analysis. PHEs and wavelet coefficients were analyzed to find the locations of singularities along the logs. Using the well logs in this study, locations of predicted singularities were used as indicators in single normal equation simulation (SNESIM) to generate equi-probable realizations of potential strata separation intervals. Horizontal and vertical variograms of realizations were then analyzed and compared with those of indicator data and training image (TI) data using the Kruskal-Wallis test. A sum of squared differences was employed to select the most probable realization representing the locations of potential strata separations and methane flow paths. Results indicated that singularities located in well log signals reliably correlated with strata transitions or discontinuities within the strata. Geostatistical simulation of these discontinuities provided information about the location and extents of the continuous channels that may form during mining. If there is a gas source within their zone of influence, paths may develop and allow methane movement towards sealed or active gobs under pressure differentials. Knowledge gained from this research will better prepare mine operations for potential methane inflows, thus improving mine safety. Abstract Copyright (2014) Elsevier, B.V. JF - Journal of Applied Geophysics AU - Karacan, C Ozgen AU - Olea, Ricardo A Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 147 EP - 158 PB - Elsevier, Amsterdam VL - 105 SN - 0926-9851, 0926-9851 KW - United States KW - mining KW - methane KW - underground mining KW - well-logging KW - statistical analysis KW - aliphatic hydrocarbons KW - geostatistics KW - alkanes KW - simulation KW - Alabama KW - Black Warrior Basin KW - organic compounds KW - sedimentary rocks KW - safety KW - longwall mining KW - wavelets KW - coal KW - hydrocarbons KW - 30:Engineering geology KW - 20:Applied geophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1855318055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Geophysics&rft.atitle=Inference+of+strata+separation+and+gas+emission+paths+in+longwall+overburden+using+continuous+wavelet+transform+of+well+logs+and+geostatistical+simulation&rft.au=Karacan%2C+C+Ozgen%3BOlea%2C+Ricardo+A&rft.aulast=Karacan&rft.aufirst=C&rft.date=2014-06-01&rft.volume=105&rft.issue=&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Geophysics&rft.issn=09269851&rft_id=info:doi/10.1016%2Fj.jappgeo.2014.03.019 L2 - http://www.sciencedirect.com/science/journal/09269851 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2017, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2017-01-01 N1 - Number of references - 44 N1 - Document feature - illus. incl. sects., sketch map N1 - Last updated - 2017-01-05 N1 - CODEN - GEOXAV N1 - SubjectsTermNotLitGenreText - Alabama; aliphatic hydrocarbons; alkanes; Black Warrior Basin; coal; geostatistics; hydrocarbons; longwall mining; methane; mining; organic compounds; safety; sedimentary rocks; simulation; statistical analysis; underground mining; United States; wavelets; well-logging DO - http://dx.doi.org/10.1016/j.jappgeo.2014.03.019 ER - TY - JOUR T1 - What radiation dose does the FISH translocation assay measure in cases of incorporated radionuclides for the Southern Urals populations? AN - 1765943162; PQ0002506213 AB - The fluorescence in situ hybridisation (FISH) technique is now well established for retrospective dosimetry in cases of external radiation exposure that occurred many years ago. However, the question remains as to whether FISH provides valid estimates of cumulative red bone marrow radiation doses in cases of incorporation of radio-nuclides or combined external and internal exposures. In this paper, an attempt is made to address the question of what FISH measures in such circumstances by considering evidence regarding the origin and lifetime dynamics of lymphocyte subsets in the human body in relation to the localized delivery of dose from the internal emitters 90Sr and 239Pu, which are of particular interest for the Southern Urals Mayak and Techa River populations, and for which most evidence is available in these populations. JF - Radiation Protection Dosimetry AU - Ainsbury, Elizabeth A AU - Moquet, Jayne AU - Rothkamm, Kai AU - Darroudi, Firouz AU - Vozilova, Alexandra AU - Degteva, Marina AU - Azizova, Tamara V AU - Lloyd, David C AU - Harrison, John AD - Public Health England (PHE) CRCE, Chilton, Didcot, Oxfordshire OX11 0RQ, UK, liz.ainsbury@phe.gov.uk Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 26 EP - 33 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 159 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Environment Abstracts KW - Rivers KW - Fluorescence KW - Russia, Chelyabinskaya, Techa R. KW - Dosimetry KW - Bone marrow KW - Assays KW - Lymphocytes KW - Russia, Ural Mts. KW - Radiation KW - Radioisotopes KW - Fish KW - Strontium KW - Translocation KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765943162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvabstractsmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=What+radiation+dose+does+the+FISH+translocation+assay+measure+in+cases+of+incorporated+radionuclides+for+the+Southern+Urals+populations%3F&rft.au=Ainsbury%2C+Elizabeth+A%3BMoquet%2C+Jayne%3BRothkamm%2C+Kai%3BDarroudi%2C+Firouz%3BVozilova%2C+Alexandra%3BDegteva%2C+Marina%3BAzizova%2C+Tamara+V%3BLloyd%2C+David+C%3BHarrison%2C+John&rft.aulast=Ainsbury&rft.aufirst=Elizabeth&rft.date=2014-06-01&rft.volume=159&rft.issue=1-4&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/10.1093%2Frpd%2Fncu118 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Rivers; Fluorescence; Radiation; Dosimetry; Bone marrow; Radioisotopes; Assays; Strontium; Fish; Lymphocytes; Translocation; Russia, Chelyabinskaya, Techa R.; Russia, Ural Mts. DO - http://dx.doi.org/10.1093/rpd/ncu118 ER - TY - JOUR T1 - The Role of eNOS Phosphorylation in Causing Drug-induced Vascular Injury AN - 1683351370; PQ0001555029 AB - Previously we found that regulation of eNOS is an important part of the pathogenic process of Drug-induced vascular injury (DIVI) for PDE4i. The aims of the current study were to examine the phosphorylation of eNOS in mesentery versus aorta at known regulatory sites across DIVI-inducing drug classes and to compare changes across species. We found that phosphorylation at S615 in rats was elevated 35-fold 2 hr after the last dose of CI-1044 in mesentery versus 3-fold in aorta. Immunoprecipitation studies revealed that many of the upstream regulators of eNOS activation were associated with eNOS in 1 or more signalosome complexes. Next rats were treated with drugs from 4 other classes known to cause DIVI. Each drug was given alone and in combination with SIN-1 (NO donor) or L-NAME (eNOS inhibitor), and the level of eNOS phosphorylation in mesentery and aorta tissue was correlated with the extent of vascular injury and measured serum nitrite. Drugs or combinations produced altered serum nitrite levels as well as vascular injury score in the mesentery. The results suggested that phosphorylation of S615 may be associated with DIVI activity. Studies with the species-specific A2A adenosine agonist CI-947 in rats versus primates showed a similar pattern. JF - Toxicologic Pathology AU - Tobin, Grainne AMcMahon AU - Zhang, Jun AU - Goodwin, David AU - Stewart, Sharron AU - Xu, Lin AU - Knapton, Alan AU - Gonzalez, Carlos AU - Bancos, Simona AU - Zhang, Leshuai AU - Lawton, Michael P AU - Enerson, Bradley E AU - Weaver, James L AD - Division of Applied Regulatory Science, CDER, U.S. Food and Drug Administration, Silver Spring, Maryland, USA, james.weaver@fda.hhs.gov Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 709 EP - 724 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 42 IS - 4 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts KW - animal models KW - vascular system KW - drug development KW - risk identification. KW - Phosphorylation KW - Injuries KW - NG-Nitroarginine methyl ester KW - Mesentery KW - signalosomes KW - Aorta KW - Immunoprecipitation KW - Nitric oxide KW - Nitrite KW - Drugs KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683351370?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=The+Role+of+eNOS+Phosphorylation+in+Causing+Drug-induced+Vascular+Injury&rft.au=Tobin%2C+Grainne+AMcMahon%3BZhang%2C+Jun%3BGoodwin%2C+David%3BStewart%2C+Sharron%3BXu%2C+Lin%3BKnapton%2C+Alan%3BGonzalez%2C+Carlos%3BBancos%2C+Simona%3BZhang%2C+Leshuai%3BLawton%2C+Michael+P%3BEnerson%2C+Bradley+E%3BWeaver%2C+James+L&rft.aulast=Tobin&rft.aufirst=Grainne&rft.date=2014-06-01&rft.volume=42&rft.issue=4&rft.spage=709&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623314522885 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 39 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - NG-Nitroarginine methyl ester; Injuries; Phosphorylation; signalosomes; Mesentery; Aorta; Immunoprecipitation; Nitric oxide; Nitrite; Drugs DO - http://dx.doi.org/10.1177/0192623314522885 ER - TY - JOUR T1 - Physiological-based pharmacokinetic modeling of endotoxin in the rat AN - 1680435825; PQ0001532515 AB - We have previously measured the distribution and pharmacokinetics of biosynthetically radiolabeled endotoxin of Salmonella typhimurium following intraperitoneal (IP) dosing (200 mu g/kg) in Sprague-Dawley rats. In our experiments, the fatty acid residues were labeled with 3H and the glucosamine residues were labeled with 14C. To predict the dynamics of endotoxin exposure, we developed a physiological-based pharmacokinetic model using our measured distribution results. The model was validated with published low-dose (30 mu g/kg) IP exposure results in rats. Endotoxin pharmacokinetics depended on dose and route. At high IP doses, absorption was followed by biphasic decay over 48 h in plasma. There were tissue accumulations of the fatty acid and glucosamine residues in various target organs, including the brain. We also found that the glucosamine and fatty acid components separated in vivo about 3 h after IP injection. At the lower IP dose, a smaller fraction of the dose was distributed to the tissues, with most of the dose remaining in the blood. Each component had its own dynamic behavior and target tissue distribution in the rat. The fatty acid components tended to remain in the brain stem, caudate nucleus, cerebellum, frontal cortex, hippocampus, and hypothalamus. Other organs (spleen, kidney, meninges, and choroid plexus) had similar biphasic distribution. The liver had the unique accumulation of both glucosamine and fatty acid residues. JF - Toxicology and Industrial Health AU - Hutter, Joseph C AU - Kim, Chung S AD - Office of Device Evaluation, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD, USA, joseph.hutter@fda.hhs.gov Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 442 EP - 453 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 30 IS - 5 SN - 0748-2337, 0748-2337 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Endotoxin KW - distribution KW - pharmacokinetic model KW - Endotoxins KW - Hippocampus KW - Glucosamine KW - Cerebellum KW - Caudate nucleus KW - Models KW - Rats KW - Meninges KW - Absorption KW - Decay KW - Residues KW - Brain stem KW - Brain KW - Spleen KW - Cortex (frontal) KW - Salmonella typhimurium KW - Organs KW - Choroid plexus KW - Pharmacokinetics KW - Blood KW - Liver KW - Kidney KW - Fatty acids KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680435825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Physiological-based+pharmacokinetic+modeling+of+endotoxin+in+the+rat&rft.au=Hutter%2C+Joseph+C%3BKim%2C+Chung+S&rft.aulast=Hutter&rft.aufirst=Joseph&rft.date=2014-06-01&rft.volume=30&rft.issue=5&rft.spage=442&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233712458140 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 30 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Endotoxins; Hippocampus; Glucosamine; Brain stem; Cerebellum; Cortex (frontal); Spleen; Caudate nucleus; Choroid plexus; Pharmacokinetics; Models; Meninges; Blood; Fatty acids; Kidney; Liver; Rats; Residues; Absorption; Brain; Decay; Organs; Salmonella typhimurium DO - http://dx.doi.org/10.1177/0748233712458140 ER - TY - JOUR T1 - Distribution and pharmacokinetics of double-radiolabeled endotoxin in the rat brain and peripheral organs AN - 1680435723; PQ0001532516 AB - The endotoxin, lipopolysaccharide (LPS), of Salmonella typhimurium was biosynthetically labeled with 3H and 14C incorporated into the fatty acyl chains and glucosamine residues, respectively. The radio-labeled LPS was isolated from the bacteria and then injected into Sprague-Dawley rats. The distribution of 14C and 3H-LPS in plasma and other organs was determined following intraperitoneal (IP) doses of 14C and 3H-LPS (200 mu g/kg). Plasma concentrations of both fatty acyl chains and glucosamine residues were biphasic, with a relatively rapid decay followed by a slow decline for 48 h. Similar biphasic results were found in the peripheral organs (kidney and heart) and brain barrier tissues (meninges and choroid plexus). In other brain tissues (brain stem, caudate nucleus, hypothalamus, frontal cortex, cerebellum and hippocampus), the glucosamine residue was biphasic, whereas the fatty acyl chains showed accumulation. Highest concentrations of LPS were found in the plasma, spleen and the liver. In addition, in the liver, sustained elevations of 14C-glucosamine and 3H-fatty acyl chains were observed. This indicates LPS accumulation in the liver. By contrast, the spleen showed biphasic decay of glucosamine residues and accumulation of fatty acyl chains. In the brain barrier tissues, peak LPS concentrations were significantly reduced (about 70%) and were further reduced (about 95%) in other brain tissues. The high elevation of LPS in the spleen is considered indicative of an immune response. Our findings highlight the potential significant role of lipid A as shown with the sustained elevation of 3H-fatty acyl chains in the brain. JF - Toxicology and Industrial Health AU - Kim, Chung S AU - Ross, Ivan A AU - Sapienza, Philip P AU - Hanes, Darcy E AU - Johnson, Widmark AU - Hutter, Joseph C AD - Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD, USA, chung.kim@fda.hhs.gov Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 432 EP - 441 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 30 IS - 5 SN - 0748-2337, 0748-2337 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Endotoxin KW - distribution KW - pharmacokinetics KW - infection KW - Endotoxins KW - Hippocampus KW - Lipids KW - Glucosamine KW - Cerebellum KW - Caudate nucleus KW - Rats KW - Meninges KW - Lipopolysaccharides KW - Decay KW - Heart KW - Residues KW - Brain stem KW - Brain KW - Cortex (frontal) KW - Spleen KW - Salmonella typhimurium KW - Organs KW - Choroid plexus KW - Pharmacokinetics KW - Kidney KW - Liver KW - Lipid A KW - Immune response KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680435723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Industrial+Health&rft.atitle=Distribution+and+pharmacokinetics+of+double-radiolabeled+endotoxin+in+the+rat+brain+and+peripheral+organs&rft.au=Kim%2C+Chung+S%3BRoss%2C+Ivan+A%3BSapienza%2C+Philip+P%3BHanes%2C+Darcy+E%3BJohnson%2C+Widmark%3BHutter%2C+Joseph+C&rft.aulast=Kim&rft.aufirst=Chung&rft.date=2014-06-01&rft.volume=30&rft.issue=5&rft.spage=432&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Industrial+Health&rft.issn=07482337&rft_id=info:doi/10.1177%2F0748233712458139 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-05-01 N1 - Number of references - 36 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Heart; Endotoxins; Hippocampus; Glucosamine; Brain stem; Cerebellum; Spleen; Caudate nucleus; Cortex (frontal); Choroid plexus; Pharmacokinetics; Meninges; Liver; Kidney; Lipopolysaccharides; Lipid A; Immune response; Rats; Residues; Lipids; Brain; Decay; Organs; Salmonella typhimurium DO - http://dx.doi.org/10.1177/0748233712458139 ER - TY - JOUR T1 - Nonclinical safety biomarkers of drug-induced vascular injury: current status and blueprint for the future. AN - 1672090598; 24777748 AB - Better biomarkers are needed to identify, characterize, and/or monitor drug-induced vascular injury (DIVI) in nonclinical species and patients. The Predictive Safety Testing Consortium (PSTC), a precompetitive collaboration of pharmaceutical companies and the U.S. Food and Drug Administration (FDA), formed the Vascular Injury Working Group (VIWG) to develop and qualify translatable biomarkers of DIVI. The VIWG focused its research on acute DIVI because early detection for clinical and nonclinical safety monitoring is desirable. The VIWG developed a strategy based on the premise that biomarkers of DIVI in rat would be translatable to humans due to the morphologic similarity of vascular injury between species regardless of mechanism. The histomorphologic lexicon for DIVI in rat defines degenerative and adaptive findings of the vascular endothelium and smooth muscles, and characterizes inflammatory components. We describe the mechanisms of these changes and their associations with candidate biomarkers for which advanced analytical method validation was completed. Further development is recommended for circulating microRNAs, endothelial microparticles, and imaging techniques. Recommendations for sample collection and processing, analytical methods, and confirmation of target localization using immunohistochemistry and in situ hybridization are described. The methods described are anticipated to aid in the identification and qualification of translational biomarkers for DIVI. © 2014 by The Author(s). JF - Toxicologic pathology AU - Mikaelian, Igor AU - Cameron, Mark AU - Dalmas, Deidre A AU - Enerson, Bradley E AU - Gonzalez, Raymond J AU - Guionaud, Silvia AU - Hoffmann, Peter K AU - King, Nicholas M P AU - Lawton, Michael P AU - Scicchitano, Marshall S AU - Smith, Holly W AU - Thomas, Roberta A AU - Weaver, James L AU - Zabka, Tanja S AU - Vascular Injury Working Group of the Predictive Safety Consortium AD - Hoffmann-La Roche Inc, Nutley, New Jersey, USA Abbvie, Worcester, Massachusetts, USA igor.mikaelian@abbvie.com. ; MPI Research, Mattawan, Michigan, USA. ; GlaxoSmithKline, King of Prussia, Pennsylvania, USA. ; Pfizer Inc, Groton, Connecticut, USA. ; Merck Research Laboratories, Merck and Co, Inc, West Point, Pennsylvania, USA. ; Shire, Hampshire International Business Park, Basingstoke, United Kingdom. ; Novartis, East Hanover, New Jersey, USA. ; Critical Path Institute, Tucson, Arizona, USA. ; Eli Lilly, Indianapolis, Indianapolis, USA. ; Food and Drug Administration, Silver Spring, Maryland, USA. ; Genentech, South San Francisco, California, USA. ; Vascular Injury Working Group of the Predictive Safety Consortium Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 635 EP - 657 VL - 42 IS - 4 KW - Biomarkers KW - 0 KW - Index Medicus KW - vasculopathy KW - arteritis KW - drug development tool KW - arteriopathy KW - animal model KW - nonclinical KW - qualification. KW - United States KW - Muscle, Smooth -- pathology KW - Animals KW - United States Food and Drug Administration KW - Endothelium, Vascular -- drug effects KW - Humans KW - Endothelium, Vascular -- pathology KW - Muscle, Smooth -- drug effects KW - Drug Evaluation, Preclinical -- trends KW - Drug-Related Side Effects and Adverse Reactions KW - Vascular System Injuries -- chemically induced KW - Vascular System Injuries -- pathology KW - Biomarkers -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1672090598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Nonclinical+safety+biomarkers+of+drug-induced+vascular+injury%3A+current+status+and+blueprint+for+the+future.&rft.au=Mikaelian%2C+Igor%3BCameron%2C+Mark%3BDalmas%2C+Deidre+A%3BEnerson%2C+Bradley+E%3BGonzalez%2C+Raymond+J%3BGuionaud%2C+Silvia%3BHoffmann%2C+Peter+K%3BKing%2C+Nicholas+M+P%3BLawton%2C+Michael+P%3BScicchitano%2C+Marshall+S%3BSmith%2C+Holly+W%3BThomas%2C+Roberta+A%3BWeaver%2C+James+L%3BZabka%2C+Tanja+S%3BVascular+Injury+Working+Group+of+the+Predictive+Safety+Consortium&rft.aulast=Mikaelian&rft.aufirst=Igor&rft.date=2014-06-01&rft.volume=42&rft.issue=4&rft.spage=635&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=1533-1601&rft_id=info:doi/10.1177%2F0192623314525686 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-12-14 N1 - Date created - 2015-04-08 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1177/0192623314525686 ER - TY - JOUR T1 - Leukoreduced whole blood-derived platelets treated with antimicrobial peptides maintain in vitro properties during storage AN - 1660397411; 20133668 AB - Bacterial sepsis is still a complication in patients transfused with stored platelets (PLTs). We have recently demonstrated that selected antimicrobial peptides (AMPs) have bactericidal activity in bacteria-spiked PLTs. In a subsequent preclinical study, we have also shown that these AMPs do not elicit antibody response in rabbits and treatment of PLTs before transfusion does not affect their in vivo recovery and survival in severe combined immunodeficient mice. Here we have selected two such AMPs, Arg-Trp (RW) repeats of tri- and tetra-peptides (RW3 and RW4) in combination (i.e., cocktail), and evaluated their effect on the in vitro properties of PLTs. Leukoreduced ABO- and D-identical whole blood-derived PLT concentrates were pooled and divided into two 60-mL aliquots in CLX storage bags. On Day 0, one bag received a peptide cocktail of RW3 plus RW4 at 0.01 mmol/L final concentration (test) and the other bag received only phosphate-buffered saline (PBS), the AMP solvent (control). The treated PLTs were stored for 7 days at 20 to 24 degree C. Samples were collected on Days 1, 5, and 7 to evaluate the in vitro properties of PLTs with standard assays. In vitro properties of the RW3 plus RW4 cocktail-treated PLTs were similar to those incubated with PBS only. There were no significant differences between the control and test PLTs during the 7-day storage. Leukoreduced whole blood-derived PLTs treated with a mixture of RW3 and RW4 peptides maintain their in vitro properties during 7 days of storage. JF - Transfusion AU - Bosch-Marce, Marta AU - Seetharaman, Shalini AU - Kurtz, James AU - Mohan, Ketha VK AU - Wagner, Stephen J AU - Atreya, Chintamani D AD - Section of Cell Biology Laboratory of Cellular Hematology Center for Biologics Evaluation and Research. Food and Drug Administration Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 1604 EP - 1609 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 54 IS - 6 SN - 0041-1132, 0041-1132 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Blood KW - Sepsis KW - Platelets KW - Immunodeficiency KW - Solvents KW - Survival KW - Antibody response KW - Transfusion KW - Antimicrobial peptides KW - Bactericidal activity KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660397411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Leukoreduced+whole+blood-derived+platelets+treated+with+antimicrobial+peptides+maintain+in+vitro+properties+during+storage&rft.au=Bosch-Marce%2C+Marta%3BSeetharaman%2C+Shalini%3BKurtz%2C+James%3BMohan%2C+Ketha+VK%3BWagner%2C+Stephen+J%3BAtreya%2C+Chintamani+D&rft.aulast=Bosch-Marce&rft.aufirst=Marta&rft.date=2014-06-01&rft.volume=54&rft.issue=6&rft.spage=1604&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Ftrf.12534 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Blood; Sepsis; Solvents; Immunodeficiency; Platelets; Survival; Antibody response; Transfusion; Bactericidal activity; Antimicrobial peptides DO - http://dx.doi.org/10.1111/trf.12534 ER - TY - JOUR T1 - The role of nodose ganglia in the regulation of cardiovascular function following pulmonary exposure to ultrafine titanium dioxide AN - 1639474012; 21120921 AB - The inhalation of nanosized air pollutant particles is a recognised risk factor for cardiovascular disease; however, the link between occupational exposure to engineered nanoparticles and adverse cardiovascular events remains unclear. In the present study, the authors demonstrated that pulmonary exposure of rats to ultrafine titanium dioxide (UFTiO sub(2)2) significantly increased heart rate and depressed diastolic function of the heart in response to isoproterenol. Moreover, pulmonary inhalation of UFTiO sub(2)2 elevated mean and diastolic blood pressure in response to norepinephrine. Pretreatment of the rats ip with the transient receptor potential (TRP) channel blocker ruthenium red inhibited substance P synthesis in nodose ganglia and associated functional and biological changes in the cardiovascular system. In conclusion, the effects of pulmonary inhalation of UFTiO sub(2)2 on cardiovascular function are most likely triggered by a lungnodose ganglia-regulated pathway via the activation of TRP channels in the lung. JF - Nanotoxicology AU - Kan, Hong AU - Wu, Zhongxin AU - Lin, Yen-Chang AU - Chen, Teh-Hsun AU - Cumpston, Jared L AU - Kashon, Michael L AU - Leonard, Steve AU - Munson, Albert E AU - Castranova, Vincent AD - Hong Kan, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, PPRB, 1095 Willowdale Road, Morgantown, WV 26505, USA, hvn4@cdc.gov Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 447 EP - 454 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 8 IS - 4 SN - 1743-5390, 1743-5390 KW - Pollution Abstracts; Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - nanoparticles KW - neural pathways KW - cardiovascular system KW - inhalation study KW - Inhalation KW - Cardiovascular system KW - Heart rate KW - Particulates KW - Blood pressure KW - Rats KW - Titanium dioxide KW - Pollutants KW - Risk factors KW - Nodose ganglion KW - transient receptor potential proteins KW - Occupational exposure KW - Ruthenium red KW - Ruthenium KW - Substance P KW - Air pollution KW - Lung KW - Norepinephrine KW - isoproterenol KW - Cardiovascular diseases KW - X 24310:Pharmaceuticals KW - P 0000:AIR POLLUTION KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639474012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=The+role+of+nodose+ganglia+in+the+regulation+of+cardiovascular+function+following+pulmonary+exposure+to+ultrafine+titanium+dioxide&rft.au=Kan%2C+Hong%3BWu%2C+Zhongxin%3BLin%2C+Yen-Chang%3BChen%2C+Teh-Hsun%3BCumpston%2C+Jared+L%3BKashon%2C+Michael+L%3BLeonard%2C+Steve%3BMunson%2C+Albert+E%3BCastranova%2C+Vincent&rft.aulast=Kan&rft.aufirst=Hong&rft.date=2014-06-01&rft.volume=8&rft.issue=4&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2013.796536 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Inhalation; Ruthenium red; Cardiovascular system; Heart rate; Substance P; Blood pressure; Titanium dioxide; Pollutants; Lung; Risk factors; Norepinephrine; Nodose ganglion; isoproterenol; Cardiovascular diseases; transient receptor potential proteins; nanoparticles; Occupational exposure; Ruthenium; Particulates; Rats; Air pollution DO - http://dx.doi.org/10.3109/17435390.2013.796536 ER - TY - JOUR T1 - Theoretical relationship between vibration transmissibility and driving-point response functions of the human body AN - 1562672454; 20456735 AB - The relationship between the vibration transmissibility and driving-point response functions (DPRFs) of the human body is important for understanding vibration exposures of the system and for developing valid models. This study identified their theoretical relationship and demonstrated that the sum of the DPRFs can be expressed as a linear combination of the transmissibility functions of the individual mass elements distributed throughout the system. The relationship is verified using several human vibration models. This study also clarified the requirements for reliably quantifying transmissibility values used as references for calibrating the system models. As an example application, this study used the developed theory to perform a preliminary analysis of the method for calibrating models using both vibration transmissibility and DPRFs. The results of the analysis show that the combined method can theoretically result in a unique and valid solution of the model parameters, at least for linear systems. However, the validation of the method itself does not guarantee the validation of the calibrated model, because the validation of the calibration also depends on the model structure and the reliability and appropriate representation of the reference function. JF - Noise and Vibration in Industry AU - Dong, Ren G AD - NIOSH, 1095 Willowdale Road, Morgantown, WV 26505, USA Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 113 PB - Multi-Science Publishing Co. Ltd., 107 High St. Brentwood, Essex CM14 4RX United Kingdom VL - 28 IS - 3 SN - 0950-8163, 0950-8163 KW - Health & Safety Science Abstracts KW - Vibration KW - Noise levels KW - H 6000:Natural Disasters/Civil Defense/Emergency Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1562672454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Noise+and+Vibration+in+Industry&rft.atitle=Theoretical+relationship+between+vibration+transmissibility+and+driving-point+response+functions+of+the+human+body&rft.au=Dong%2C+Ren+G&rft.aulast=Dong&rft.aufirst=Ren&rft.date=2014-06-01&rft.volume=28&rft.issue=3&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Noise+and+Vibration+in+Industry&rft.issn=09508163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2015-09-30 N1 - SubjectsTermNotLitGenreText - Vibration; Noise levels ER - TY - JOUR T1 - Predicting Temporal Trends in Total Absenteeism Rates for Civil Service Employees of a Federal Public Health Agency AN - 1560120087; 20469199 AB - Objective: This study evaluates the predictability in temporal absences trends due to all causes (total absenteeism) among employees at a federal agency. The objective is to determine how leave trends vary within the year, and determine whether trends are predictable. Methods: Ten years of absenteeism data from an attendance system were analyzed for rates of total absence. Results: Trends over a 10-year period followed predictable and regular patterns during a given year that correspond to major holiday periods. Temporal trends in leave among small, medium, and large facilities compared favorably with the agency as a whole. Conclusions: Temporal trends in total absenteeism rates for an organization can be determined using its attendance system. The ability to predict employee absenteeism rates can be extremely helpful for management in optimizing business performance and ensuring that an organization meets its mission. JF - Journal of Occupational and Environmental Medicine AU - Spears, D Ross AU - McNeil, Carrie AU - Warnock, Eli AU - Trapp, Jonathan AU - Oyinloye, Oluremi AU - Whitehurst, Vanessa AU - Decker, K C AU - Chapman, Sandy AU - Campbell, Morris AU - Meechan, Paul AD - Environment Safety and Health Compliance Office; US Public Health Service, Senior Science Officer, Occupational Health and Preventive Services, Office of Safety, Security and Asset Management, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, MS F-05, Atlanta, GA 30333, ava3@cdc.gov PY - 2014 SP - 632 EP - 638 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 56 IS - 6 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Public health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560120087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Predicting+Temporal+Trends+in+Total+Absenteeism+Rates+for+Civil+Service+Employees+of+a+Federal+Public+Health+Agency&rft.au=Spears%2C+D+Ross%3BMcNeil%2C+Carrie%3BWarnock%2C+Eli%3BTrapp%2C+Jonathan%3BOyinloye%2C+Oluremi%3BWhitehurst%2C+Vanessa%3BDecker%2C+K+C%3BChapman%2C+Sandy%3BCampbell%2C+Morris%3BMeechan%2C+Paul&rft.aulast=Spears&rft.aufirst=D&rft.date=2014-06-01&rft.volume=56&rft.issue=6&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000155 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Public health DO - http://dx.doi.org/10.1097/JOM.0000000000000155 ER - TY - JOUR T1 - Physical Assaults Among Education Workers: Findings From a Statewide Study AN - 1560115271; 20469197 AB - Objective: Enumerate and describe physical assaults occurring to Pennsylvania education workers. Methods: A cross-sectional survey was mailed to a random sample of 6450 workers, stratified on gender, occupation, and region. Logistic regression was used to examine risk factors for physical assault. Results: During the 2009-2010 school year, 309 of 2514 workers were assaulted 597 times. Special education teachers, urban workers, and those in their first 3 years of employment were at an increased risk. Most assaults did not lead to medical care or time away from work; however, those assaulted were significantly more likely to find work stressful, have low job satisfaction, and consider leaving the education field (adjusted odds ratio [AOR] = 2.5 [95% CI = 1.5 to 4.1]; AOR = 2.4 [95% CI = 1.5 to 3.9]; AOR = 10.7 [95% CI = 4.1 to 28.1]). Conclusions: Although education workers experienced few serious physical assaults, the impact of this violence was considerable. JF - Journal of Occupational and Environmental Medicine AU - Tiesman, Hope M AU - Hendricks, Scott AU - Konda, Srinivas AU - Hartley, Dan AD - National Institute for Occupational Safety and Health, Division of Safety Research, Analysis and Field Evaluations Branch, 1095 Willowdale Rd, M/S 1811, Morgantown, WV 26506, htiesman@cdc.gov PY - 2014 SP - 621 EP - 627 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 56 IS - 6 SN - 1076-2752, 1076-2752 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Education KW - Schools KW - Risk factors KW - USA, Pennsylvania KW - Gender KW - Employment KW - Violence KW - H 1000:Occupational Safety and Health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560115271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Physical+Assaults+Among+Education+Workers%3A+Findings+From+a+Statewide+Study&rft.au=Tiesman%2C+Hope+M%3BHendricks%2C+Scott%3BKonda%2C+Srinivas%3BHartley%2C+Dan&rft.aulast=Tiesman&rft.aufirst=Hope&rft.date=2014-06-01&rft.volume=56&rft.issue=6&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000147 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Education; Schools; Risk factors; Gender; Employment; Violence; USA, Pennsylvania DO - http://dx.doi.org/10.1097/JOM.0000000000000147 ER - TY - JOUR T1 - THE MEDICAL DECISION MODEL AND DECISION MAKER TOOLS FOR MANAGEMENT OF RADIOLOGICAL AND NUCLEAR INCIDENTS AN - 1551643938; 20284291 AB - Effective decision making during a rapidly evolving emergency such as a radiological or nuclear incident requires timely interim decisions and communications from onsite decision makers while further data processing, consultation, and review are ongoing by reachback experts. The authors have recently proposed a medical decision model for use during a radiological or nuclear disaster, which is similar in concept to that used in medical care, especially when delay in action can have disastrous effects. For decision makers to function most effectively during a complex response, they require access to onsite subject matter experts who can provide information, recommendations, and participate in public communication efforts. However, in the time before this expertise is available or during the planning phase, just-in-time tools are essential that provide critical overview of the subject matter written specifically for the decision makers. Recognizing the complexity of the science, risk assessment, and multitude of potential response assets that will be required after a nuclear incident, the Office of the Assistant Secretary for Preparedness and Response, in collaboration with other government and non-government experts, has prepared a practical guide for decision makers. This paper illustrates how the medical decision model process could facilitate onsite decision making that includes using the deliberative reachback process from science and policy experts and describes the tools now available to facilitate timely and effective incident management. JF - Health Physics AU - Koerner, John F AU - Coleman, C Norman AU - Murrain-Hill, Paula AU - FitzGerald, Denis J AU - Sullivan, Julie M AD - Office of Emergency Management, Office of the Assistant Secretary for Preparedness and Response, U.S. Department of Health and Human Services, Washington, DC 20201, john.koerner@hhs.gov Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 645 EP - 651 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 106 IS - 6 SN - 0017-9078, 0017-9078 KW - Risk Abstracts KW - accidents KW - nuclear KW - power reactor KW - emergencies KW - radiological KW - risk communication KW - Decision models KW - Risk assessment KW - Decision making KW - Communications KW - Data processing KW - Reviews KW - Disasters KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551643938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=THE+MEDICAL+DECISION+MODEL+AND+DECISION+MAKER+TOOLS+FOR+MANAGEMENT+OF+RADIOLOGICAL+AND+NUCLEAR+INCIDENTS&rft.au=Koerner%2C+John+F%3BColeman%2C+C+Norman%3BMurrain-Hill%2C+Paula%3BFitzGerald%2C+Denis+J%3BSullivan%2C+Julie+M&rft.aulast=Koerner&rft.aufirst=John&rft.date=2014-06-01&rft.volume=106&rft.issue=6&rft.spage=645&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0000000000000053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-08-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Decision models; Decision making; Data processing; Communications; Reviews; Disasters DO - http://dx.doi.org/10.1097/HP.0000000000000053 ER - TY - JOUR T1 - A 10-Year Clinical and Radiographic Study of Implants Placed after Maxillary Sinus Floor Augmentation with an 80:20 Mixture of Deproteinized Bovine Bone and Autogenous Bone AN - 1547854294; 20236160 AB - There is a need for prospective, long-term follow-up studies of implants placed after maxillary sinus floor augmentation (MSFA). The aim of the present study was to determine whether deprotenized bovine bone (DPBB) used for MSFA may result in long-term stability of placed dental implants. Fourteen of the 20 patients included in the study were followed throughout the 10 years study period. These patients had 53 implants placed in 22 (6 unilateral and 8 bilateral) maxillary sinuses augmented with a mixture of 80% DPBB and 20% autogenous bone (80:20), and 15 implants placed in non-grafted sites. Clinical and radiographic examinations of the implants and grafts were performed. After 10 years of functional loading 15 of the initially placed 108 implants had been lost giving a cumulative survival rate of 86%. The mean marginal bone loss was 1.6 plus or minus 1.0 mm. There were no statistically significant differences in marginal bone level, pocket depth, or ISQ-values between implants placed in residual or grafted bone or between smokers or non-smokers at 10 years follow-up. There was a statistically significant reduction (p < .01) in graft height between 3 months and 2 years but no further significant reduction up to 10 years. The first 2 years after placement of implants with turned surfaces placed in sites after sinus floor augmentation with DPBB and autogenous bone seem to be critical for implant survival. At 10 years follow-up, the remaining implants presented excellent clinical and radiological results regardless of smoking habits or implant sites (augmented or residual bone). JF - Clinical Implant Dentistry and Related Research AU - Mordenfeld, Arne AU - Albrektsson, Tomas AU - Hallman, Mats AD - Department of Oral & Maxillofacial Surgery. Public Health Service Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 435 EP - 446 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 16 IS - 3 SN - 1523-0899, 1523-0899 KW - Calcium & Calcified Tissue Abstracts; Biotechnology and Bioengineering Abstracts KW - Dental restorative materials KW - Maxilla KW - Loading KW - Bone grafts KW - Statistical analysis KW - Survival KW - Sinus KW - Dentistry KW - Maxillary sinus KW - Smoking KW - Bone loss KW - Bone implants KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1547854294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Implant+Dentistry+and+Related+Research&rft.atitle=A+10-Year+Clinical+and+Radiographic+Study+of+Implants+Placed+after+Maxillary+Sinus+Floor+Augmentation+with+an+80%3A20+Mixture+of+Deproteinized+Bovine+Bone+and+Autogenous+Bone&rft.au=Mordenfeld%2C+Arne%3BAlbrektsson%2C+Tomas%3BHallman%2C+Mats&rft.aulast=Mordenfeld&rft.aufirst=Arne&rft.date=2014-06-01&rft.volume=16&rft.issue=3&rft.spage=435&rft.isbn=&rft.btitle=&rft.title=Clinical+Implant+Dentistry+and+Related+Research&rft.issn=15230899&rft_id=info:doi/10.1111%2Fcid.12008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2014-08-21 N1 - SubjectsTermNotLitGenreText - Smoking; Dental restorative materials; Loading; Maxilla; Bone loss; Statistical analysis; Bone grafts; Survival; Sinus; Dentistry; Bone implants; Maxillary sinus DO - http://dx.doi.org/10.1111/cid.12008 ER - TY - JOUR T1 - Applications of dermal microdialysis: a review AN - 1547849626; 20292750 AB - Microdialysis (MD) is a sampling technique used to assess tissue concentrations of analytes producing a real-time dynamic drug profile. It's been almost 25 years since MD saw application in sampling and measuring skin concentrations following topical and transdermal applications. The purpose of this review is to provide a technical overview of MD and summarize the widespread applications that are explored with dermal or cutaneous MD ranging from a potential tool to establish topical bioequivalence to unraveling the mechanisms of inflammatory skin disorders. This review also includes current regulatory perspectives in order to benefit scientists and/or clinicians who are called novices in this area. JF - Journal of Drug Delivery Science and Technology AU - Shukla, C AU - Bashaw, E D AU - Stagni, G AU - Benfeldt, E AD - Office of Clinical Pharmacology, Center for Drug Evaluations and Research, US FDA, 10903 New Hampshire Avenue, Silver Spring, Maryland 20993, United States, Chinmay.Shukla@fda.hhs.gov Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 259 EP - 269 PB - Editions de Sante, 49, rue Galilee Paris 75116 France VL - 24 IS - 3 SN - 1773-2247, 1773-2247 KW - Biotechnology and Bioengineering Abstracts KW - Sampling KW - Kinetics KW - Flow rate KW - Dialysate KW - Permeation KW - Microdialysis KW - Drug delivery KW - Skin KW - Inflammatory diseases KW - Reviews KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1547849626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Drug+Delivery+Science+and+Technology&rft.atitle=Applications+of+dermal+microdialysis%3A+a+review&rft.au=Shukla%2C+C%3BBashaw%2C+E+D%3BStagni%2C+G%3BBenfeldt%2C+E&rft.aulast=Shukla&rft.aufirst=C&rft.date=2014-06-01&rft.volume=24&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+Drug+Delivery+Science+and+Technology&rft.issn=17732247&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Microdialysis; Drug delivery; Skin; Inflammatory diseases; Reviews; Sampling ER - TY - JOUR T1 - Fronto-limbic-striatal dysfunction in pediatric and adult patients with bipolar disorder: impact of face emotion and attentional demands AN - 1541979861; 201415508 AB - Research in bipolar disorder (BD) implicates fronto-limbic-striatal dysfunction during face emotion processing but it is unknown how such dysfunction varies by task demands, face emotion and patient age. During functional magnetic resonance imaging (fMRI), 181 participants, including 62 BD (36 children and 26 adults) and 119 healthy comparison (HC) subjects (57 children and 62 adults), engaged in constrained and unconstrained processing of emotional (angry, fearful, happy) and non-emotional (neutral) faces. During constrained processing, subjects answered questions focusing their attention on the face; this was processed either implicitly (nose width rating) or explicitly (hostility; subjective fear ratings). Unconstrained processing consisted of passive viewing. Pediatric BD rated neutral faces as more hostile than did other groups. In BD patients, family-wise error (FWE)-corrected region of interest (ROI) analyses revealed dysfunction in the amygdala, inferior frontal gyrus (IFG), anterior cingulate cortex (ACC) and putamen. Patients with BD showed amygdala hyperactivation during explicit processing (hostility ratings) of fearful faces and passive viewing of angry and neutral faces but IFG hypoactivation during implicit processing of neutral and happy faces. In the ACC and striatum, the direction of dysfunction varied by task demand: BD demonstrated hyperactivation during unconstrained processing of angry or neutral faces but hypoactivation during constrained processing (implicit or explicit) of angry, neutral or happy faces. Findings suggest amygdala hyperactivation in BD while processing negatively valenced and neutral faces, regardless of attentional condition, and BD IFG hypoactivation during implicit processing. In the cognitive control circuit involving the ACC and putamen, BD neural dysfunction was sensitive to task demands. Adapted from the source document. JF - Psychological Medicine AU - Brotman, M A AU - Tseng, W.-L. AU - Olsavsky, A K AU - Fromm, S J AU - Muhrer, E J AU - Rutenberg, J G AU - Deveney, C M AU - Adleman, N E AU - Zarate, C A AU - Pine, D S AU - Leibenluft, E AD - Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA brotmanm@mail.nih.gov Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 1639 EP - 1651 PB - Cambridge University Press, UK VL - 44 IS - 8 SN - 0033-2917, 0033-2917 KW - Paediatrics KW - Emotions KW - Hostility KW - Facial expressions KW - Dysfunction KW - Anger KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541979861?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Fronto-limbic-striatal+dysfunction+in+pediatric+and+adult+patients+with+bipolar+disorder%3A+impact+of+face+emotion+and+attentional+demands&rft.au=Brotman%2C+M+A%3BTseng%2C+W.-L.%3BOlsavsky%2C+A+K%3BFromm%2C+S+J%3BMuhrer%2C+E+J%3BRutenberg%2C+J+G%3BDeveney%2C+C+M%3BAdleman%2C+N+E%3BZarate%2C+C+A%3BPine%2C+D+S%3BLeibenluft%2C+E&rft.aulast=Brotman&rft.aufirst=M&rft.date=2014-06-01&rft.volume=44&rft.issue=8&rft.spage=1639&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS003329171300202X LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-07-01 N1 - Number of references - 77 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Dysfunction; Facial expressions; Anger; Emotions; Paediatrics; Hostility DO - http://dx.doi.org/10.1017/S003329171300202X ER - TY - JOUR T1 - Moving Toward Patient-Centered Care: Women's Decisions, Perceptions, and Experiences of the Induction of Labor Process AN - 1540220236; 19994136 AB - Patient preferences and clinician practices are possible causative factors to explain the increase in induction of labor, but scientific studies that demonstrate this link are limited. The purpose of this study is to identify factors that influence inductions from the perspective of women. A qualitative investigation using grounded theory methodology was conducted. Women were interviewed preinduction and postinduction. Analysis of the interviews was conducted using constant comparison to identify codes, categories, and themes. Through this process the complex intersection between women, their clinician, and the application of evidence-based care in clinical practice was explored. Five major themes from the preinduction interview were identified; safety of baby, women's trust in their clinician, relief of discomfort and/or anxiety, diminish potential or actual risk, and lack of informed decision making. Five major themes were identified from the postinduction interview; lack of informed decision making, induction as part of a checklist, women's trust in their clinician, happy with induction, and opportunities to improve the experience. Lack of informed decision making was cited as a barrier to optimal care. This study has important implications for patient-centered research and clinical care, requiring the inclusion of women and the salient concepts of care that they identify. JF - Birth AU - Moore, Jennifer E AU - Low, Lisa Kane AU - Titler, Marita G AU - Dalton, Vanessa K AU - Sampselle, Carolyn M AD - U.S. Department of Health and Human Services. Agency for Healthcare Research and Quality Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 138 EP - 146 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 41 IS - 2 SN - 0730-7659, 0730-7659 KW - Risk Abstracts KW - Decision making KW - Perception KW - Risk factors KW - Safety KW - Females KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1540220236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth&rft.atitle=Moving+Toward+Patient-Centered+Care%3A+Women%27s+Decisions%2C+Perceptions%2C+and+Experiences+of+the+Induction+of+Labor+Process&rft.au=Moore%2C+Jennifer+E%3BLow%2C+Lisa+Kane%3BTitler%2C+Marita+G%3BDalton%2C+Vanessa+K%3BSampselle%2C+Carolyn+M&rft.aulast=Moore&rft.aufirst=Jennifer&rft.date=2014-06-01&rft.volume=41&rft.issue=2&rft.spage=138&rft.isbn=&rft.btitle=&rft.title=Birth&rft.issn=07307659&rft_id=info:doi/10.1111%2Fbirt.12080 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Decision making; Perception; Risk factors; Safety; Females DO - http://dx.doi.org/10.1111/birt.12080 ER - TY - JOUR T1 - A Summary of the Evidence for the Change in European Distribution of Phlebotomine Sand Flies (Diptera: Psychodidae) of Public Health Importance AN - 1534829787; 19961194 AB - The phlebotomine sand flies (Diptera: Psychodidae, Phlebotominae) are vectors of several infectious pathogens. The presence of a sand fly vector is considered to be a risk factor for the emergence of leishmaniasis in temperate Europe. Hence, the occurrence of phlebotomine sand flies and any changes in their distribution is important in determining the potential change in distribution of leishmaniasis in Europe. Therefore, published evidence for a changing distribution of the important phlebotomine sand fly vectors of leishmaniasis and phlebovirus infection in Europe is reviewed. This paper presents evidence of an increasing risk of establishment by sand fly species, especially for the Atlantic Coast and inland parts of Germany, Switzerland, and Austria. In addition to detection in potentially appropriate areas, the findings show areas of potential future establishment of the species. The most important and urgent necessity within the community of entomologists working on phlebotomines is the need to record the extremes of distribution of each species and obtain data on their regional presence/absence along with increased sharing of the data throughout European projects. JF - Journal of Vector Ecology AU - Medlock, Jolyon M AU - Hansford, Kayleigh M AU - Bortel, Wim Van AU - Zeller, Herve AU - Alten, Bulent AD - Medical Entomology group, Emergency Response Department, Public Health England, Porton Down, Salisbury, Wiltshire. United Kingdom, jolyon.medlock@phe.gov.uk Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 72 EP - 77 PB - Society for Vector Ecology VL - 39 IS - 1 SN - 1081-1710, 1081-1710 KW - Entomology Abstracts; Risk Abstracts; Health & Safety Science Abstracts; Ecology Abstracts KW - Phlebotomus KW - sand flies KW - Europe KW - distribution KW - Phlebotominae KW - Leishmaniasis KW - Data processing KW - Vectors KW - Austria KW - Pathogens KW - Infection KW - Switzerland KW - Phlebovirus KW - Public health KW - Coastal zone KW - Sand KW - Psychodidae KW - Reviews KW - Risk factors KW - ANE, Germany KW - Diptera KW - Coasts KW - D 04040:Ecosystem and Ecology Studies KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - H 12000:Epidemiology and Public Health KW - R2 23050:Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534829787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Vector+Ecology&rft.atitle=A+Summary+of+the+Evidence+for+the+Change+in+European+Distribution+of+Phlebotomine+Sand+Flies+%28Diptera%3A+Psychodidae%29+of+Public+Health+Importance&rft.au=Medlock%2C+Jolyon+M%3BHansford%2C+Kayleigh+M%3BBortel%2C+Wim+Van%3BZeller%2C+Herve%3BAlten%2C+Bulent&rft.aulast=Medlock&rft.aufirst=Jolyon&rft.date=2014-06-01&rft.volume=39&rft.issue=1&rft.spage=72&rft.isbn=&rft.btitle=&rft.title=Journal+of+Vector+Ecology&rft.issn=10811710&rft_id=info:doi/10.1111%2Fj.1948-7134.2014.12072.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Number of references - 61 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Leishmaniasis; Data processing; Risk factors; Reviews; Vectors; Pathogens; Infection; Coasts; Public health; Coastal zone; Sand; Phlebotominae; Psychodidae; Diptera; Phlebovirus; Austria; ANE, Germany; Switzerland DO - http://dx.doi.org/10.1111/j.1948-7134.2014.12072.x ER - TY - JOUR T1 - Identification of an Outer Membrane Lipoprotein Involved in Nasopharyngeal Colonization by Moraxella catarrhalis in an Animal Model AN - 1534829245; 19968479 AB - Colonization of the human nasopharynx by Moraxella catarrhalis is presumed to involve attachment of this bacterium to the mucosa. DNA microarray analysis was used to determine whether attachment of M. catarrhalis to human bronchial epithelial (HBE) cells in vitro affected gene expression in this bacterium. Attachment affected expression of at least 454 different genes, with 163 being upregulated and 291 being downregulated. Among the upregulated genes was one (ORF113) previously annotated as encoding a protein with some similarity to outer membrane protein A (OmpA). The protein encoded by ORF113 was predicted to have a signal peptidase II cleavage site, and globomycin inhibition experiments confirmed that this protein was indeed a lipoprotein. The ORF113 protein also contained a predicted peptidoglycan-binding domain in its C-terminal half. The use of mutant and recombinant M. catarrhalis strains confirmed that the ORF113 protein was present in outer membrane preparations, and this protein was also shown to be at least partially exposed on the bacterial cell surface. A mutant unable to produce the ORF113 protein showed little or no change in its growth rate in vitro, in its ability to attach to HBE cells in vitro, or in its autoagglutination characteristics, but it did exhibit a reduced ability to survive in the chinchilla nasopharynx. This is the first report of a lipoprotein essential to the ability of M. catarrhalis to persist in an animal model. JF - Infection and Immunity AU - Wang, Wei AU - Joslin, Stephanie N AU - Pybus, Christine AU - Evans, Amanda S AU - Lichaa, Flora AU - Brautigam, Chad A AU - Hansen, Eric J AD - Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA, wei02.wang@fda.hhs.gov. Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 2287 EP - 2299 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 6 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Growth rate KW - Cell surface KW - Globomycin KW - outer membrane proteins KW - Mucosa KW - Moraxella catarrhalis KW - Animal models KW - Nasopharynx KW - DNA microarrays KW - Gene expression KW - Colonization KW - signal peptidase KW - Lipoproteins KW - Rodentia KW - J 02410:Animal Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534829245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Identification+of+an+Outer+Membrane+Lipoprotein+Involved+in+Nasopharyngeal+Colonization+by+Moraxella+catarrhalis+in+an+Animal+Model&rft.au=Wang%2C+Wei%3BJoslin%2C+Stephanie+N%3BPybus%2C+Christine%3BEvans%2C+Amanda+S%3BLichaa%2C+Flora%3BBrautigam%2C+Chad+A%3BHansen%2C+Eric+J&rft.aulast=Wang&rft.aufirst=Wei&rft.date=2014-06-01&rft.volume=82&rft.issue=6&rft.spage=2287&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01745-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Number of references - 81 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Growth rate; Gene expression; Globomycin; Cell surface; Colonization; outer membrane proteins; signal peptidase; Mucosa; Lipoproteins; Animal models; Nasopharynx; DNA microarrays; Moraxella catarrhalis; Rodentia DO - http://dx.doi.org/10.1128/IAI.01745-14 ER - TY - JOUR T1 - Evaluation of the activity of ertapenem against gonococcal isolates exhibiting a range of susceptibilities to cefixime AN - 1534821134; 19987525 AB - Objectives There is a need for new or alternative antimicrobial agents for the treatment of gonorrhoea as antimicrobial resistance emerges to current therapies. The aim was to investigate the activity of ertapenem against isolates of Neisseria gonorrhoeae with decreased susceptibility to cefixime. Methods A panel of 52 clinical isolates and 10 control strains of N. gonorrhoeae were selected to represent a range of susceptibilities to cefixime. Susceptibility testing was performed using the methodology used for the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP). The isolates were typed by N. gonorrhoeae multi-antigen sequence typing (NG-MAST). Results The isolates comprised 42 different molecular types as defined by NG-MAST. The susceptibility of the clinical isolates to ertapenem was similar to that of cefixime, with a Pearson's correlation coefficient of R=0.89. The MIC sub(90) and MIC sub(50) values of ertapenem were 0.25 and 0.12 mg/L, respectively, while those of cefixime were 0.12 and 0.06 mg/L, respectively. However, these isolates were more susceptible to ceftriaxone than ertapenem, with a Pearson's correlation coefficient of R=0.65 and ceftriaxone MIC sub(90) and MIC sub(50) values of 0.03 and 0.016 mg/L, respectively. The isolates that were least susceptible to ertapenem were all non-producers of penicillinase. However, one isolate that was highly resistant to cefixime and ceftriaxone was more susceptible to ertapenem than either cefixime or ceftriaxone. Conclusions This study has shown that ertapenem is not a suitable alternative for first-line treatment for gonorrhoea but that it may be useful for the treatment of highly resistant infections. JF - Journal of Antimicrobial Chemotherapy AU - Quaye, Nerteley AU - Cole, Michelle J AU - Ison, Catherine A AD - Corresponding author. Tel: +44-(0)20-8327-6462; Fax: +44-(0)20-8327-6474, catherine.ison@phe.gov.uk Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 1568 EP - 1571 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 69 IS - 6 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - Typing KW - Drug resistance KW - ertapenem KW - Cefixime KW - Ceftriaxone KW - Infection KW - Neisseria gonorrhoeae KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534821134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Evaluation+of+the+activity+of+ertapenem+against+gonococcal+isolates+exhibiting+a+range+of+susceptibilities+to+cefixime&rft.au=Quaye%2C+Nerteley%3BCole%2C+Michelle+J%3BIson%2C+Catherine+A&rft.aulast=Quaye&rft.aufirst=Nerteley&rft.date=2014-06-01&rft.volume=69&rft.issue=6&rft.spage=1568&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkt537 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Typing; Drug resistance; Cefixime; ertapenem; Ceftriaxone; Infection; Antimicrobial agents; Neisseria gonorrhoeae DO - http://dx.doi.org/10.1093/jac/dkt537 ER - TY - JOUR T1 - Current Status of Multipotent Mesenchymal Stromal Cells AN - 1534819167; 19986461 JF - Tissue Engineering, Part B: Reviews AU - Husain, Syed R AU - Ohya, Yoshikazu AU - Toguchida, Junya AU - Puri, Raj K AD - Division of Cellular and Gene Therapies, Food and Drug Administration, Center for Biologics Evaluation and Research, Bethesda, Maryland. Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 189 PB - Mary Ann Liebert, Inc., 140 Huguenot St 3rd Fl New Rochelle NY 10801 United States VL - 20 IS - 3 SN - 1937-3368, 1937-3368 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534819167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering%2C+Part+B%3A+Reviews&rft.atitle=Current+Status+of+Multipotent+Mesenchymal+Stromal+Cells&rft.au=Husain%2C+Syed+R%3BOhya%2C+Yoshikazu%3BToguchida%2C+Junya%3BPuri%2C+Raj+K&rft.aulast=Husain&rft.aufirst=Syed&rft.date=2014-06-01&rft.volume=20&rft.issue=3&rft.spage=189&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering%2C+Part+B%3A+Reviews&rft.issn=19373368&rft_id=info:doi/10.1089%2Ften.teb.2014.0105 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Number of references - 2 N1 - Last updated - 2014-06-12 DO - http://dx.doi.org/10.1089/ten.teb.2014.0105 ER - TY - JOUR T1 - Breast cancer risk after occupational solvent exposure: the influence of timing and setting. AN - 1531956773; 24879566 AB - Organic solvents are ubiquitous in occupational settings where they may contribute to risks for carcinogenesis. However, there is limited information on organic solvents as human breast carcinogens. We examined the relationship between occupational exposure to solvents and breast cancer in a prospective study of 47,661 women with an occupational history in the Sister Study cohort. Occupational solvent exposure was categorized using self-reported job-specific solvent use collected at baseline. Multivariable Cox regression analyses were used to assess breast cancer risk, adjusting for established breast cancer risk factors. A total of 1,798 women were diagnosed with breast cancer during follow-up, including 1,255 invasive cases. Overall the risk of invasive breast cancer was not associated with lifetime exposure to solvents [HR, 1.04; 95% confidence interval (CI), 0.88-1.24]. Parous women who worked with solvents before their first full-term birth had an increased risk of estrogen receptor-positive invasive breast cancer compared with women who never worked with solvents (HR, 1.39; 95% CI, 1.03-1.86). A significantly elevated risk for estrogen receptor-positive invasive breast cancer was associated with solvent exposure among clinical laboratory technologists and technicians (HR, 2.00; 95% CI, 1.07-3.73). Occupational exposure to solvents before first birth, a critical period of breast tissue differentiation, may result in increased vulnerability for breast cancer. Our findings suggest a need for future studies in this area to focus on exposure time windows and solvent types in different occupational settings. ©2014 American Association for Cancer Research. JF - Cancer research AU - Ekenga, Christine C AU - Parks, Christine G AU - D'Aloisio, Aimee A AU - DeRoo, Lisa A AU - Sandler, Dale P AD - Authors' Affiliations: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway christine.ekenga@nih.gov. ; Authors' Affiliations: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. ; Authors' Affiliations: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, NorwayAuthors' Affiliations: Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Department of Health and Human Services, Research Triangle Park, North Carolina; and Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. Y1 - 2014/06/01/ PY - 2014 DA - 2014 Jun 01 SP - 3076 EP - 3083 VL - 74 IS - 11 KW - Receptors, Estrogen KW - 0 KW - Solvents KW - Index Medicus KW - Self Report KW - Prospective Studies KW - Risk Factors KW - Humans KW - Cohort Studies KW - Middle Aged KW - Receptors, Estrogen -- metabolism KW - United States -- epidemiology KW - Puerto Rico -- epidemiology KW - Female KW - Occupational Exposure -- statistics & numerical data KW - Occupational Diseases -- metabolism KW - Solvents -- poisoning KW - Occupational Exposure -- adverse effects KW - Breast Neoplasms -- metabolism KW - Occupational Diseases -- epidemiology KW - Breast Neoplasms -- epidemiology KW - Breast Neoplasms -- chemically induced KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1531956773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Breast+cancer+risk+after+occupational+solvent+exposure%3A+the+influence+of+timing+and+setting.&rft.au=Ekenga%2C+Christine+C%3BParks%2C+Christine+G%3BD%27Aloisio%2C+Aimee+A%3BDeRoo%2C+Lisa+A%3BSandler%2C+Dale+P&rft.aulast=Ekenga&rft.aufirst=Christine&rft.date=2014-06-01&rft.volume=74&rft.issue=11&rft.spage=3076&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-13-2430 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-08-28 N1 - Date created - 2014-06-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Am J Ind Med. 2000 Apr;37(4):349-52 [10706746] J Natl Cancer Inst. 2013 Apr 17;105(8):515-25 [23449445] Environ Health Perspect. 2002 Aug;110(8):805-11 [12153763] Environ Health Perspect. 2003 Jun;111(8):1007-19 [12826474] Radiat Res. 2003 Dec;160(6):707-17 [14640793] Carcinogenesis. 1995 Feb;16(2):173-9 [7859345] Cancer Epidemiol Biomarkers Prev. 1995 Jul-Aug;4(5):567-71 [7549816] Am J Ind Med. 1997 Jul;32(1):1-14 [9131206] IARC Monogr Eval Carcinog Risks Hum. 1995;63:33-477 [9139128] Occup Environ Med. 1998 Mar;55(3):161-71 [9624267] Am J Ind Med. 1998 Nov;34(5):477-83 [9787852] Epidemiology. 1999 Jan;10(1):37-48 [9888278] Am J Ind Med. 1999 Jul;36(1):43-7 [10361585] Am J Ind Med. 1999 Jul;36(1):48-53 [10361586] Scand J Work Environ Health. 1999 Jun;25(3):215-21 [10450771] Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):61-6 [15668477] Am J Ind Med. 2005 Sep;48(3):157-67 [16094615] Int J Cancer. 2007 Jul 15;121(2):386-94 [17372900] Cancer Causes Control. 2007 Nov;18(9):947-55 [17632764] Environ Health Perspect. 2007 Oct;115(10):1406-14 [17938728] BMC Med Res Methodol. 2008;8:70 [18973665] Endocr Rev. 2009 Jun;30(4):293-342 [19502515] Environ Health Perspect. 2010 Mar;118(3):375-81 [20194067] Occup Environ Med. 2010 Apr;67(4):263-9 [20360196] Environ Health. 2010;9:40 [20646273] Occup Environ Med. 2010 Nov;67(11):722-9 [19819862] Arch Intern Med. 2011 Jan 24;171(2):125-33 [21263102] Am J Ind Med. 2011 Jul;54(7):499-509 [21472744] Environ Health. 2012;11:87 [23164221] J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):43-61 [23417729] Environ Health Perspect. 2001 Jul;109(7):699-703 [11485868] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/0008-5472.CAN-13-2430 ER - TY - JOUR T1 - Metzincins and related genes in experimental renal ageing: towards a unifying fibrosis classifier across species. AN - 1530951871; 24569495 AB - We have previously described a transcriptomic classifier consisting of metzincins and related genes (MARGS) discriminating kidneys and other organs with or without fibrosis from human biopsies. We now apply our MARGS-based algorithm to a rat model of age-associated interstitial renal fibrosis. Untreated Fisher 344 rats (n = 76) were sacrificed between 2 to 104 weeks of age. For gene expression studies, we used single colour (Cy3) Agilent Whole Rat Genome 4 × 44k microarrays; 4-5 animals of each sex were profiled at each of the following ages: 2, 5, 6, 8, 15, 21, 78 and 104 weeks. Intensity data were subjected to variance stabilization (www.Partek.com). Data were analysed with ANOVA and other statistical methods. Sixty MARGS were differentially expressed across age groups. More MARGS were differentially expressed in older males than in older females. Principal component analysis showed gene expression induced segregation of age groups by sex from 6 to 104 weeks of age. The expression level of MMP7 correlated best with fibrosis grade. Severity of fibrosis was determined in 20 animals at 78 and 104 weeks of age. Expression values of 15 of 19 genes of the original classifier present on the Agilent array, in conjunction with linear discriminant analysis, was sufficient to correctly classify these 20 samples into non-fibrosis and fibrosis. Overrepresentation of MMP2 protein and CD44 protein in fibrosis was confirmed by immunofluorescence. Based on these results and our previous work, the MARGS classifier represents a cross-organ and cross-species classifier of fibrosis irrespective of aetiology. This finding provides evidence for a common pathway leading to fibrosis and will help to design a PCR-based clinical test. © The Author 2014. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. JF - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association AU - Marti, Hans-Peter AU - Fuscoe, James C AU - Kwekel, Joshua C AU - Anagnostopoulou, Aikaterini AU - Scherer, Andreas AD - Department of Clinical Medicine, University of Bergen, Bergen, Norway. ; Division of Systems Biology, National Center for Toxicological Research, FDA, Jefferson, AR, USA. ; Institute of Anatomy, University of Bern, Bern, Switzerland. ; Spheromics, Kontiolahti, Finland. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 1177 EP - 1185 VL - 29 IS - 6 KW - Matrix Metalloproteinase 7 KW - EC 3.4.24.23 KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Index Medicus KW - metzincins KW - CD44 KW - matrix metalloproteinases KW - classifier KW - ageing KW - fibrosis KW - Rats KW - Polymerase Chain Reaction KW - Animals KW - Rats, Inbred F344 KW - Fibrosis KW - Principal Component Analysis KW - Matrix Metalloproteinase 7 -- metabolism KW - Microarray Analysis KW - Algorithms KW - Disease Models, Animal KW - Matrix Metalloproteinase 2 -- metabolism KW - Male KW - Female KW - Transcriptome -- physiology KW - Kidney -- pathology KW - Kidney -- physiology KW - Aging -- pathology KW - Kidney -- physiopathology KW - Gene Expression Profiling -- methods KW - Aging -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1530951871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephrology%2C+dialysis%2C+transplantation+%3A+official+publication+of+the+European+Dialysis+and+Transplant+Association+-+European+Renal+Association&rft.atitle=Metzincins+and+related+genes+in+experimental+renal+ageing%3A+towards+a+unifying+fibrosis+classifier+across+species.&rft.au=Marti%2C+Hans-Peter%3BFuscoe%2C+James+C%3BKwekel%2C+Joshua+C%3BAnagnostopoulou%2C+Aikaterini%3BScherer%2C+Andreas&rft.aulast=Marti&rft.aufirst=Hans-Peter&rft.date=2014-06-01&rft.volume=29&rft.issue=6&rft.spage=1177&rft.isbn=&rft.btitle=&rft.title=Nephrology%2C+dialysis%2C+transplantation+%3A+official+publication+of+the+European+Dialysis+and+Transplant+Association+-+European+Renal+Association&rft.issn=1460-2385&rft_id=info:doi/10.1093%2Fndt%2Fgfu027 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-07 N1 - Date created - 2014-05-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/ndt/gfu027 ER - TY - JOUR T1 - Obesity and other risk factors: The National Survey of U.S. Long-Haul Truck Driver Health and Injury AN - 1529945582; 19846512 AB - Background Drivers of heavy and tractor-trailer trucks accounted for 56% of all production and nonsupervisory employees in the truck transportation industry in 2011. There are limited data for illness and injury in long-haul truck drivers, which prompted a targeted national survey. Methods Interviewers collected data during 2010 from 1,670 long-haul truck drivers at 32 truck stops across the 48 contiguous United States that were used to compute prevalence estimates for self-reported health conditions and risk factors. Results Obesity (69% vs. 31%, P<0.01) and current smoking (51% vs. 19%, P<0.01) were twice as prevalent in long-haul truck drivers as in the 2010 U.S. adult working population. Sixty-one percent reported having two or more of the risk factors: hypertension, obesity, smoking, high cholesterol, no physical activity, 6 or fewer hours of sleep per 24-hr period. Conclusion Survey findings suggest a need for targeted interventions and continued surveillance for long-haul truck drivers. Am. J. Ind. Med. 57:615-626, 2014. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Sieber, WKarl AU - Robinson, Cynthia F AU - Birdsey, Jan AU - Chen, Guang X AU - Hitchcock, Edward M AU - Lincoln, Jennifer E AU - Nakata, Akinori AU - Sweeney, Marie H AD - Division of Surveillance, Hazard Evaluations, and Field Studies, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 615 EP - 626 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 6 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Obesity KW - Injuries KW - Physical activity KW - Intervention KW - Cholesterol KW - Smoking KW - USA KW - Transportation KW - Risk factors KW - Trucks KW - Hypertension KW - Agricultural equipment KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1529945582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Obesity+and+other+risk+factors%3A+The+National+Survey+of+U.S.+Long-Haul+Truck+Driver+Health+and+Injury&rft.au=Sieber%2C+WKarl%3BRobinson%2C+Cynthia+F%3BBirdsey%2C+Jan%3BChen%2C+Guang+X%3BHitchcock%2C+Edward+M%3BLincoln%2C+Jennifer+E%3BNakata%2C+Akinori%3BSweeney%2C+Marie+H&rft.aulast=Sieber&rft.aufirst=WKarl&rft.date=2014-06-01&rft.volume=57&rft.issue=6&rft.spage=615&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22293 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Smoking; Obesity; Transportation; Injuries; Physical activity; Risk factors; Intervention; Trucks; Cholesterol; Agricultural equipment; Hypertension; USA DO - http://dx.doi.org/10.1002/ajim.22293 ER - TY - JOUR T1 - NIOSH Health and Safety Practices Survey of Healthcare Workers: Training and awareness of employer safety procedures AN - 1529944642; 19846514 AB - Background The Health and Safety Practices Survey of Healthcare Workers describes current practices used to minimize chemical exposures and barriers to using recommended personal protective equipment for the following: antineoplastic drugs, anesthetic gases, high level disinfectants, surgical smoke, aerosolized medications (pentamidine, ribavirin, and antibiotics), and chemical sterilants. Methods Twenty-one healthcare professional practice organizations collaborated with NIOSH to develop and implement the web-based survey. Results Twelve thousand twenty-eight respondents included professional, technical, and support occupations which routinely come in contact with the targeted hazardous chemicals. Chemical-specific safe handling training was lowest for aerosolized antibiotics (52%, n=316), and surgical smoke (57%, n=4,747). Reported employer procedures for minimizing exposure was lowest for surgical smoke (32%, n=4,746) and anesthetic gases (56%, n=3,604). Conclusions Training and having procedures in place to minimize exposure to these chemicals is one indication of employer and worker safety awareness. Safe handling practices for use of these chemicals will be reported in subsequent papers. Am. J. Ind. Med. 57:640-652, 2014. copyright 2014 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Steege, Andrea L AU - Boiano, James M AU - Sweeney, Marie H AD - Surveillance Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio, 45226-1998. Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 640 EP - 652 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 6 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Smoke KW - Disinfectants KW - Gases KW - Training KW - Surgery KW - Occupational safety KW - Antineoplastic drugs KW - Antibiotics KW - Protective equipment KW - Medical personnel KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1529944642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=NIOSH+Health+and+Safety+Practices+Survey+of+Healthcare+Workers%3A+Training+and+awareness+of+employer+safety+procedures&rft.au=Steege%2C+Andrea+L%3BBoiano%2C+James+M%3BSweeney%2C+Marie+H&rft.aulast=Steege&rft.aufirst=Andrea&rft.date=2014-06-01&rft.volume=57&rft.issue=6&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22305 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Smoke; Disinfectants; Gases; Training; Surgery; Occupational safety; Antineoplastic drugs; Antibiotics; Protective equipment; Occupational exposure; Medical personnel DO - http://dx.doi.org/10.1002/ajim.22305 ER - TY - JOUR T1 - Partial least square and k-nearest neighbor algorithms for improved 3D quantitative spectral data-activity relationship consensus modeling of acute toxicity. AN - 1526131550; 24464801 AB - A diverse set of 154 chemicals that included US Food and Drug Administration-regulated compounds tested for their aquatic toxicity in Daphnia magna were modeled by a 3-dimensional quantitative spectral data-activity relationship (3D-QSDAR). Two distinct algorithms, partial least squares (PLS) and Tanimoto similarity-based k-nearest neighbors (KNN), were used to process bin occupancy descriptor matrices obtained after tessellation of the 3D-QSDAR space into regularly sized bins. The performance of models utilizing bins ranging in size from 2 ppm × 2 ppm × 0.5 Å to 20 ppm × 20 ppm × 2.5 Å was explored. Rigorous quality-control criteria were imposed: 1) 100 randomized 20% hold-out test sets were generated and the average R(2) test of the respective models was used as a measure of their performance, and 2) a Y-scrambling procedure was used to identify chance correlations. A consensus between the best-performing composite PLS model using 0.5 Å × 14 ppm × 14 ppm bins and 10 latent variables (average R(2) test  = 0.770) and the best composite KNN model using 0.5 Å × 8 ppm × 8 ppm and 2 neighbors (average R(2) test  = 0.801) offered an improvement of about 7.5% (R(2) test consensus  = 0.845). Projection of the most frequently occurring bins on the standard coordinate space indicated that the presence of a primary or secondary amino group-substituted aromatic systems-would result in an increased toxic effect in Daphnia. The presence of a second aromatic ring with highly electronegative substituents 5 Å to 7 Å apart from the first ring would lead to a further increase in toxicity. © 2014 SETAC. JF - Environmental toxicology and chemistry AU - Stoyanova-Slavova, Iva B AU - Slavov, Svetoslav H AU - Pearce, Bruce AU - Buzatu, Dan A AU - Beger, Richard D AU - Wilkes, Jon G AD - Division of Systems Biology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arizona. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 1271 EP - 1282 VL - 33 IS - 6 KW - Environmental Pollutants KW - 0 KW - Index Medicus KW - Multivariate statistic KW - Computational toxicology KW - 3D quantitative spectral data-activity relationship (QSDAR) KW - Consensus modeling KW - Aquatic toxicology KW - United States KW - Animals KW - Endpoint Determination KW - Least-Squares Analysis KW - Cluster Analysis KW - Daphnia -- drug effects KW - Environmental Pollutants -- toxicity KW - Quantitative Structure-Activity Relationship KW - Ecotoxicology KW - Algorithms KW - Environmental Pollutants -- chemistry KW - Consensus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1526131550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+toxicology+and+chemistry&rft.atitle=Partial+least+square+and+k-nearest+neighbor+algorithms+for+improved+3D+quantitative+spectral+data-activity+relationship+consensus+modeling+of+acute+toxicity.&rft.au=Stoyanova-Slavova%2C+Iva+B%3BSlavov%2C+Svetoslav+H%3BPearce%2C+Bruce%3BBuzatu%2C+Dan+A%3BBeger%2C+Richard+D%3BWilkes%2C+Jon+G&rft.aulast=Stoyanova-Slavova&rft.aufirst=Iva&rft.date=2014-06-01&rft.volume=33&rft.issue=6&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=Environmental+toxicology+and+chemistry&rft.issn=1552-8618&rft_id=info:doi/10.1002%2Fetc.2534 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-22 N1 - Date created - 2014-05-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/etc.2534 ER - TY - JOUR T1 - Reproductive toxicity in rats with crystal nephropathy following high doses of oral melamine or cyanuric acid. AN - 1526129262; 24582682 AB - The industrial chemical melamine was used in 2007 and 2008 to raise the apparent protein content in pet feed and watered down milk, respectively. Because humans may be exposed to melamine via several different routes into the human diet as well as deliberate contamination, this study was designed to characterize the effect of high dose melamine or cyanuric acid oral exposure on the pregnant animal and developing fetus, including placental transfer. Clear rectangular crystals formed following a single triazine exposure which is a different morphology from the golden spherulites caused by combined exposure or the calculi formed when melamine combines with endogenous uric acid. Crystal nephropathy, regardless of cause, induces renal failure which in turn has reproductive sequelae. Specifically, melamine alone-treated dams had increased numbers of early and late fetal deaths compared to controls or cyanuric acid-treated dams. As melamine was found in the amniotic fluid, this study confirms transfer of melamine from mammalian mother to fetus and our study provides evidence that cyanuric acid also appears in the amniotic fluid if mothers are exposed to high doses. Published by Elsevier Ltd. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Stine, Cynthia B AU - Reimschuessel, Renate AU - Keltner, Zachary AU - Nochetto, Cristina B AU - Black, Thomas AU - Olejnik, Nicholas AU - Scott, Michael AU - Bandele, Omari AU - Nemser, Sarah M AU - Tkachenko, Andriy AU - Evans, Eric R AU - Crosby, Tina C AU - Ceric, Olgica AU - Ferguson, Martine AU - Yakes, Betsy J AU - Sprando, Robert AD - Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: cynthia.stine@fda.hhs.gov. ; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: renate.reimschuessel@fda.hhs.gov. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: zachary.keltner@fda.hhs.gov. ; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: cristina.nochetto@fda.hhs.gov. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: thomas.black@fda.hhs.gov. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: nicholas.olejnik@fda.hhs.gov. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: michael.scott@fda.hhs.gov. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: omari.bandele@fda.hhs.gov. ; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: sarah.nemser@fda.hhs.gov. ; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: andriy.tkachenko@fda.hhs.gov. ; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: eric.evans@fda.hhs.gov. ; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: tina.crosby@fda.hhs.gov. ; Center for Veterinary Medicine, US Food and Drug Administration, 8401 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: olgica.ceric@fda.hhs.gov. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: martine.ferguson@fda.hhs.gov. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. Electronic address: betsy.yakes@fda.hhs.gov. ; Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: robert.sprando@fda.hhs.gov. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 142 EP - 153 VL - 68 KW - Triazines KW - 0 KW - Creatinine KW - AYI8EX34EU KW - cyanuric acid KW - H497R4QKTZ KW - melamine KW - N3GP2YSD88 KW - Index Medicus KW - Rats KW - Reproductive toxicity KW - Melamine KW - Cyanuric acid KW - Administration, Oral KW - Animals KW - Animal Feed KW - Dose-Response Relationship, Drug KW - Food Contamination -- analysis KW - Body Weight -- drug effects KW - Toxicity Tests KW - Blood Urea Nitrogen KW - Creatinine -- blood KW - Male KW - Female KW - Organ Size -- drug effects KW - Triazines -- toxicity KW - Renal Insufficiency -- pathology KW - Renal Insufficiency -- chemically induced KW - Reproduction -- drug effects KW - Triazines -- administration & dosage KW - Maternal Exposure KW - Triazines -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1526129262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Reproductive+toxicity+in+rats+with+crystal+nephropathy+following+high+doses+of+oral+melamine+or+cyanuric+acid.&rft.au=Stine%2C+Cynthia+B%3BReimschuessel%2C+Renate%3BKeltner%2C+Zachary%3BNochetto%2C+Cristina+B%3BBlack%2C+Thomas%3BOlejnik%2C+Nicholas%3BScott%2C+Michael%3BBandele%2C+Omari%3BNemser%2C+Sarah+M%3BTkachenko%2C+Andriy%3BEvans%2C+Eric+R%3BCrosby%2C+Tina+C%3BCeric%2C+Olgica%3BFerguson%2C+Martine%3BYakes%2C+Betsy+J%3BSprando%2C+Robert&rft.aulast=Stine&rft.aufirst=Cynthia&rft.date=2014-06-01&rft.volume=68&rft.issue=&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2014.02.029 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-05 N1 - Date created - 2014-05-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2014.02.029 ER - TY - JOUR T1 - Campylobacter infection associated with consumption of duck liver pate: a retrospective cohort study in the setting of near universal exposure AN - 1524414454; 19787183 AB - A retrospective cohort study was performed following several reported cases of gastrointestinal illness after a catered event. The attack rate was 45/77 (58.4%) by clinical case definition, with four individuals confirmed to have Campylobacter. There was near universal exposure to most foodstuffs served; consumption of duck liver pate [relative risk (RR) 2.53, 95% confidence interval (CI) 1.05-6.10], mixed leaf salad (RR 2.91, 95% CI 1.22-6.92) and table water (RR undefined, P < 0.01) were associated with illness in univariate analysis, with only the latter associated in the final multivariable model (P < 0.001). Samples of cooked duck liver pate subsequently prepared using identical methods at the venue were contaminated with Campylobacter jejuni and C. coli; water sampling was negative. Making inferences about causation in the presence of near universal exposures in this study required consideration of the limitations of statistical analysis, with the most compelling evidence of the causal role of inadequately prepared duck liver pate provided by environmental investigation. JF - Epidemiology and Infection AU - Young, N J AU - Day, J AU - Montsho-Hammond, F AU - Verlander, N Q AU - Irish, C AU - PANKHANIA, B AU - Oliver, I AD - Public Health England, South of England Region, UK, nick.young@phe.gov.uk Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 1269 EP - 1276 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 142 IS - 6 SN - 0950-2688, 0950-2688 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Risk assessment KW - Water sampling KW - Statistical analysis KW - Leaves KW - Infection KW - Models KW - Food consumption KW - Campylobacter jejuni KW - Liver KW - J 02410:Animal Diseases KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524414454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Campylobacter+infection+associated+with+consumption+of+duck+liver+pate%3A+a+retrospective+cohort+study+in+the+setting+of+near+universal+exposure&rft.au=Young%2C+N+J%3BDay%2C+J%3BMontsho-Hammond%2C+F%3BVerlander%2C+N+Q%3BIrish%2C+C%3BPANKHANIA%2C+B%3BOliver%2C+I&rft.aulast=Young&rft.aufirst=N&rft.date=2014-06-01&rft.volume=142&rft.issue=6&rft.spage=1269&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS0950268813001969 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Number of references - 24 N1 - Last updated - 2016-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Food consumption; Water sampling; Leaves; Statistical analysis; Liver; Infection; Models; Campylobacter jejuni DO - http://dx.doi.org/10.1017/S0950268813001969 ER - TY - JOUR T1 - Dietary nitrate and nitrite intake and risk of colorectal cancer in the Shanghai Women's Health Study AN - 1524397976; 19625526 AB - Nitrate and nitrite are precursors of endogenously formed N-nitroso compounds (NOC), known animal carcinogens. Nitrosation reactions forming NOCs can be inhibited by vitamin C and other antioxidants. We prospectively investigated the association between dietary nitrate and nitrite intake and risk of colorectal cancer in the Shanghai Women's Health Study, a cohort of 73,118 women ages 40-70 residing in Shanghai. We evaluated effect modification by factors that affect endogenous formation of NOCs: vitamin C (at or above/below median) and red meat intake (at or above/below median). Nitrate, nitrite and other dietary intakes were estimated from a 77-item food frequency questionnaire administered at baseline. Over a mean of 11 years of follow-up, we identified 619 colorectal cancer cases (n=383, colon; n=236, rectum). Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazard regression. Overall, nitrate intake was not associated with colorectal cancer risk (HR=1.08; 95% CI: 0.73-1.59). However, among women with vitamin C intake below the median (83.9 mg day super(-1)) and hence higher potential exposure to NOCs, risk of colorectal cancer increased with increasing quintiles of nitrate intake (highest vs. lowest quintile HR=2.45; 95% CI: 1.15-5.18; p trend=0.02). There was no association among women with higher vitamin C intake. We found no association between nitrite intake and risk of colorectal cancer overall or by intake level of vitamin C. Our findings suggest that high dietary nitrate intake among subgroups expected to have higher exposure to endogenously formed NOCs increases risk of colorectal cancer. What's new? Nitrate and nitrite are precursors in the endogenous formation of potentially carcinogenic N-nitroso compounds (NOC). These nitrosation reactions are linked to the consumption of red meat and can be inhibited by vitamin C and other antioxidants. Here, a potential association of dietary nitrate, nitrite and vitamin C intake with the risk of colorectal cancer was investigated in Chinese women. The authors find an increased risk of colorectal cancer in women with high nitrate intake and low vitamin C consumption linking high endogenous NOC exposure to colorectal carcinogenesis. JF - International Journal of Cancer AU - DellaValle, Curt T AU - Xiao, Qian AU - Yang, Gong AU - Shu, Xiao-Ou AU - Aschebrook-Kilfoy, Briseis AU - Zheng, Wei AU - Lan Li, Hong AU - Ji, Bu-Tian AU - Rothman, Nathaniel AU - Chow, Wong-Ho AU - Gao, Yu-Tang AU - Ward, Mary H AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD. Y1 - 2014/06// PY - 2014 DA - Jun 2014 SP - 2917 EP - 2926 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 134 IS - 12 SN - 0020-7136, 0020-7136 KW - Health & Safety Science Abstracts; Risk Abstracts KW - Diets KW - Antioxidants KW - Nitrates KW - Ingestion KW - Cancer KW - Meat KW - Health risks KW - Nitrites KW - Carcinogenicity KW - Risk factors KW - Vitamins KW - Carcinogenesis KW - Colorectal carcinoma KW - China, People's Rep., Shanghai KW - Females KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524397976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Dietary+nitrate+and+nitrite+intake+and+risk+of+colorectal+cancer+in+the+Shanghai+Women%27s+Health+Study&rft.au=DellaValle%2C+Curt+T%3BXiao%2C+Qian%3BYang%2C+Gong%3BShu%2C+Xiao-Ou%3BAschebrook-Kilfoy%2C+Briseis%3BZheng%2C+Wei%3BLan+Li%2C+Hong%3BJi%2C+Bu-Tian%3BRothman%2C+Nathaniel%3BChow%2C+Wong-Ho%3BGao%2C+Yu-Tang%3BWard%2C+Mary+H&rft.aulast=DellaValle&rft.aufirst=Curt&rft.date=2014-06-01&rft.volume=134&rft.issue=12&rft.spage=2917&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.28612 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Diets; Antioxidants; Nitrates; Ingestion; Cancer; Meat; Health risks; Nitrites; Carcinogenicity; Vitamins; Risk factors; Carcinogenesis; Colorectal carcinoma; Females; China, People's Rep., Shanghai DO - http://dx.doi.org/10.1002/ijc.28612 ER - TY - JOUR T1 - Enhancing food safety management in Taiwan. AN - 1524341715; 24726624 JF - Journal of the Formosan Medical Association = Taiwan yi zhi AU - Kang, Jaw-Jou AU - Liu, Chiareiy AU - Tsai, Shu-Jean AD - Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan. ; Food and Drug Administration, Department of Health, Taipei, Taiwan. ; Director, Division of Food Safety, Food and Drug Administration, Ministry of Health and Welfare, Taipei, Taiwan. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 331 EP - 333 VL - 113 IS - 6 SN - 0929-6646, 0929-6646 KW - Index Medicus KW - Taiwan KW - Humans KW - Risk Assessment KW - Food Safety KW - Safety Management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524341715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Formosan+Medical+Association+%3D+Taiwan+yi+zhi&rft.atitle=Enhancing+food+safety+management+in+Taiwan.&rft.au=Kang%2C+Jaw-Jou%3BLiu%2C+Chiareiy%3BTsai%2C+Shu-Jean&rft.aulast=Kang&rft.aufirst=Jaw-Jou&rft.date=2014-06-01&rft.volume=113&rft.issue=6&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Formosan+Medical+Association+%3D+Taiwan+yi+zhi&rft.issn=09296646&rft_id=info:doi/10.1016%2Fj.jfma.2014.02.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-18 N1 - Date created - 2014-05-13 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jfma.2014.02.012 ER - TY - JOUR T1 - Ribonucleotide incorporation by yeast DNA polymerase ζ. AN - 1524176962; 24674899 AB - During replication in yeast, the three B family DNA replicases frequently incorporate ribonucleotides (rNMPs) into DNA, and their presence in the nuclear genome can affect genome stability. This prompted us to examine ribonucleotide incorporation by the fourth B family member, Pol ζ, the enzyme responsible for the majority of damage-induced mutagenesis in eukaryotes. We first show that Pol ζ inserts rNMPs into DNA and can extend primer termini containing 3'-ribonucleotides. We then measure rNMP incorporation by Pol ζ in the presence of its cofactors, RPA, RFC and PCNA and at normal cellular dNTP and rNTP concentrations that exist under unstressed conditions. Under these conditions, Pol ζ stably incorporates one rNMP for every 200-300 dNMPs incorporated, a frequency that is slightly higher than for the high fidelity replicative DNA polymerases. Under damage-induced conditions wherein cellular dNTP concentrations are elevated 5-fold, Pol ζ only incorporates one rNMP per 1300 dNMPs. Functional interaction of Pol ζ with the mutasome assembly factor Rev1 gives comparable rNMP incorporation frequencies. These results suggest that ribonucleotide incorporation into DNA during Pol ζ-mediated mutagenesis in vivo may be rare. Copyright © 2014 Elsevier B.V. All rights reserved. JF - DNA repair AU - Makarova, Alena V AU - Nick McElhinny, Stephanie A AU - Watts, Brian E AU - Kunkel, Thomas A AU - Burgers, Peter M AD - Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA. ; Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. ; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: burgers@biochem.wustl.edu. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 63 EP - 67 VL - 18 KW - DNA, Fungal KW - 0 KW - Deoxyribonucleotides KW - REV7 protein, S cerevisiae KW - RFA1 protein, S cerevisiae KW - Replication Protein A KW - Ribonucleotides KW - Saccharomyces cerevisiae Proteins KW - DNA polymerase zeta KW - EC 2.7.7.- KW - Nucleotidyltransferases KW - REV1 protein, S cerevisiae KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - REV3 protein, S cerevisiae KW - Index Medicus KW - DNA polymerase KW - Translesion synthesis KW - Mutagenesis KW - Nucleotidyltransferases -- metabolism KW - Nucleotidyltransferases -- genetics KW - DNA Damage KW - Deoxyribonucleotides -- metabolism KW - Replication Protein A -- metabolism KW - Mutation KW - DNA Replication KW - Saccharomyces cerevisiae Proteins -- metabolism KW - Saccharomyces cerevisiae Proteins -- genetics KW - Ribonucleotides -- metabolism KW - Saccharomyces cerevisiae -- enzymology KW - DNA, Fungal -- metabolism KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524176962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Ribonucleotide+incorporation+by+yeast+DNA+polymerase+%CE%B6.&rft.au=Makarova%2C+Alena+V%3BNick+McElhinny%2C+Stephanie+A%3BWatts%2C+Brian+E%3BKunkel%2C+Thomas+A%3BBurgers%2C+Peter+M&rft.aulast=Makarova&rft.aufirst=Alena&rft.date=2014-06-01&rft.volume=18&rft.issue=&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=1568-7856&rft_id=info:doi/10.1016%2Fj.dnarep.2014.02.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-06 N1 - Date created - 2014-05-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Biol Chem. 2000 May 12;275(19):14541-9 [10799539] Science. 2014 Jan 17;343(6168):260-1 [24436412] Biochem Soc Trans. 2001 May;29(Pt 2):187-91 [11356151] Cell. 2003 Feb 7;112(3):391-401 [12581528] EMBO J. 2003 Dec 15;22(24):6621-30 [14657033] J Biol Chem. 1988 Jan 15;263(2):917-24 [3275661] J Biol Chem. 1994 Apr 15;269(15):11121-32 [8157639] Nature. 1996 Aug 22;382(6593):729-31 [8751446] Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1619-22 [9050827] Genetics. 1997 Nov;147(3):1017-24 [9383049] Curr Biol. 2006 Mar 21;16(6):586-90 [16546083] EMBO J. 2006 Sep 20;25(18):4316-25 [16957771] Nucleic Acids Res. 2006;34(17):4731-42 [16971464] Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4949-54 [20194773] Biochemistry. 2010 Jul 6;49(26):5504-10 [20518555] Genetics. 2011 Jan;187(1):21-35 [20980236] DNA Repair (Amst). 2012 Aug 1;11(8):649-56 [22682724] Mol Cell. 2012 Sep 28;47(6):980-6 [22864116] PLoS Genet. 2012;8(11):e1003030 [23144626] Nucleic Acids Res. 2012 Dec;40(22):11618-26 [23066099] DNA Repair (Amst). 2013 Feb 1;12(2):121-7 [23245697] Mol Cell. 2013 May 9;50(3):323-32 [23603115] Mol Cell. 2013 May 9;50(3):437-43 [23603118] Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12942-7 [23882084] Genes Dev. 2001 Apr 15;15(8):945-54 [11316789] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.dnarep.2014.02.017 ER - TY - JOUR T1 - Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells. AN - 1524171906; 24595819 AB - Ginkgo biloba has been used for many thousand years as a traditional herbal remedy and its extract has been consumed for many decades as a dietary supplement. Ginkgo biloba leaf extract is a complex mixture with many constituents, including flavonol glycosides and terpene lactones. The National Toxicology Program 2-year cancer bioassay found that G. biloba leaf extract targets the liver, thyroid gland, and nose of rodents; however, the mechanism of G. biloba leaf extract-associated carcinogenicity remains unclear. In the current study, the in vitro genotoxicity of G. biloba leaf extract and its eight constituents was evaluated using the mouse lymphoma assay (MLA) and Comet assay. The underlying mechanisms of G. biloba leaf extract-associated genotoxicity were explored. Ginkgo biloba leaf extract, quercetin, and kaempferol resulted in a dose-dependent increase in the mutant frequency and DNA double-strand breaks (DSBs). Western blot analysis confirmed that G. biloba leaf extract, quercetin, and kaempferol activated the DNA damage signaling pathway with increased expression of γ-H2AX and phosphorylated Chk2 and Chk1. In addition, G. biloba leaf extract produced reactive oxygen species and decreased glutathione levels in L5178Y cells. Loss of heterozygosity analysis of mutants indicated that G. biloba leaf extract, quercetin, and kaempferol treatments resulted in extensive chromosomal damage. These results indicate that G. biloba leaf extract and its two constituents, quercetin and kaempferol, are mutagenic to the mouse L5178Y cells and induce DSBs. Quercetin and kaempferol likely are major contributors to G. biloba leaf extract-induced genotoxicity. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Lin, Haixia AU - Guo, Xiaoqing AU - Zhang, Suhui AU - Dial, Stacey L AU - Guo, Lei AU - Manjanatha, Mugimane G AU - Moore, Martha M AU - Mei, Nan AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, Jefferson, Arkansas 72079. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 338 EP - 349 VL - 139 IS - 2 KW - Ginkgo biloba extract 50 KW - 0 KW - Kaempferols KW - Mutagens KW - Plant Extracts KW - Reactive Oxygen Species KW - kaempferol KW - 731P2LE49E KW - Quercetin KW - 9IKM0I5T1E KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - DNA damage KW - Ginkgo biloba leaf extract KW - quercetin KW - quercetin 3-β-d-glucoside KW - genotoxicity KW - oxidative stress KW - Reactive Oxygen Species -- metabolism KW - Comet Assay KW - Animals KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Glutathione -- metabolism KW - Quercetin -- toxicity KW - Cell Culture Techniques KW - Mice KW - Plant Leaves -- chemistry KW - Kaempferols -- toxicity KW - Cell Line KW - DNA Damage KW - Plant Extracts -- toxicity KW - Mutagens -- toxicity KW - Ginkgo biloba -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524171906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Mechanistic+evaluation+of+Ginkgo+biloba+leaf+extract-induced+genotoxicity+in+L5178Y+cells.&rft.au=Lin%2C+Haixia%3BGuo%2C+Xiaoqing%3BZhang%2C+Suhui%3BDial%2C+Stacey+L%3BGuo%2C+Lei%3BManjanatha%2C+Mugimane+G%3BMoore%2C+Martha+M%3BMei%2C+Nan&rft.aulast=Lin&rft.aufirst=Haixia&rft.date=2014-06-01&rft.volume=139&rft.issue=2&rft.spage=338&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu037 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-29 N1 - Date created - 2014-05-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu037 ER - TY - JOUR T1 - Dose- and time-dependent epigenetic changes in the livers of Fisher 344 rats exposed to furan. AN - 1524168697; 24614236 AB - The presence of furan in common cooked foods along with evidence from experimental studies that lifetime exposure to furan causes liver tumors in rats and mice has caused concern to regulatory public health agencies worldwide; however, the mechanisms of the furan-induced hepatocarcinogenicity remain unclear. The goal of the present study was to investigate whether or not long-term exposure to furan causes epigenetic alterations in rat liver. Treating of male Fisher 344 rats by gavage 5 days per week with 0, 0.92, 2.0, or 4.4 mg furan/kg body weight (bw)/day resulted in dose- and time-dependent epigenetic changes consisting of alterations in DNA methylation and histone lysine methylation and acetylation, altered expression of chromatin modifying genes, and gene-specific methylation. Specifically, exposure to furan at doses 0.92, 2.0, or 4.4 mg furan/kg bw/day caused global DNA demethylation after 360 days of treatment. There was also a sustained decrease in the levels of histone H3 lysine 9 and H4 lysine 20 trimethylation after 180 and 360 days of furan exposure, and a marked reduction of histone H3 lysine 9 and H3 lysine 56 acetylation after 360 days at 4.4 mg/kg bw/day. These histone modification changes were accompanied by a reduced expression of Suv39h1, Prdm2, and Suv4-20h2 histone methyltransferases and Ep300 and Kat2a histone acetyltransferases. Additionally, furan at 2.0 and 4.4 mg/kg bw/day induced hypermethylation-dependent down-regulation of the Rassf1a gene in the livers after 180 and 360 days. These findings indicate possible involvement of dose- and time-dependent epigenetic modifications in the furan hepatotoxicity and carcinogenicity. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Conti, Aline de AU - Kobets, Tetyana AU - Escudero-Lourdes, Claudia AU - Montgomery, Beverly AU - Tryndyak, Volodymyr AU - Beland, Frederick Alan AU - Doerge, Daniel R AU - Pogribny, Igor Petrovych AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, Arkansas, 72079 USA. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 371 EP - 380 VL - 139 IS - 2 KW - Environmental Pollutants KW - 0 KW - Furans KW - Histone-Lysine N-Methyltransferase KW - EC 2.1.1.43 KW - furan KW - UC0XV6A8N9 KW - Index Medicus KW - Animals KW - Rats, Inbred F344 KW - Histone-Lysine N-Methyltransferase -- genetics KW - Dose-Response Relationship, Drug KW - Time Factors KW - Male KW - Environmental Pollutants -- toxicity KW - Liver -- drug effects KW - Epigenesis, Genetic -- drug effects KW - DNA Methylation -- drug effects KW - Furans -- toxicity KW - Liver -- metabolism KW - DNA Methylation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524168697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Dose-+and+time-dependent+epigenetic+changes+in+the+livers+of+Fisher+344+rats+exposed+to+furan.&rft.au=Conti%2C+Aline+de%3BKobets%2C+Tetyana%3BEscudero-Lourdes%2C+Claudia%3BMontgomery%2C+Beverly%3BTryndyak%2C+Volodymyr%3BBeland%2C+Frederick+Alan%3BDoerge%2C+Daniel+R%3BPogribny%2C+Igor+Petrovych&rft.aulast=Conti&rft.aufirst=Aline&rft.date=2014-06-01&rft.volume=139&rft.issue=2&rft.spage=371&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu044 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-29 N1 - Date created - 2014-05-12 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Annu Rev Pharmacol Toxicol. 2002;42:501-25 [11807181] Environ Health Perspect. 2010 Nov;118(11):1597-602 [20562052] Adv Cancer Res. 2003;90:209-30 [14710952] Carcinogenesis. 2004 Sep;25(9):1779-86 [15073043] Semin Cancer Biol. 2004 Dec;14(6):427-32 [15489135] IARC Monogr Eval Carcinog Risks Hum. 1995;63:393-407 [9097102] Mol Carcinog. 1997 Apr;18(4):199-205 [9142214] J Biol Chem. 2005 May 6;280(18):17986-91 [15757890] FEBS J. 2006 Jul;273(14):3121-35 [16857008] Drug Metab Rev. 2006;38(4):615-26 [17145691] Toxicol Lett. 2007 Feb 28;169(1):43-50 [17224250] Cell. 2007 Feb 23;128(4):683-92 [17320506] Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Mar;25(3):259-64 [18311619] Environ Sci Technol. 2008 Feb 15;42(4):1324-31 [18351112] Mutat Res. 2008 Dec 8;657(2):127-32 [18804178] Exp Toxicol Pathol. 2009 Mar;61(2):101-11 [18809303] Curr Opin Pediatr. 2009 Apr;21(2):243-51 [19663042] Biochim Biophys Acta. 2009 Dec;1796(2):114-28 [19344752] Toxicol Pathol. 2010 Feb;38(2):230-43 [20124500] Mutagenesis. 2010 May;25(3):305-14 [20194422] Arch Toxicol. 2010 Jul;84(7):563-78 [20237914] Adv Genet. 2010;70:277-308 [20920752] J Hepatol. 2011 May;54(5):939-47 [21145824] Toxicology. 2012 Feb 26;292(2-3):63-70 [22079235] Mutat Res. 2012 Feb 18;742(1-2):72-8 [22200623] Mol Nutr Food Res. 2012 Aug;56(8):1197-211 [22641279] Mol Nutr Food Res. 2012 Sep;56(9):1363-74 [22865590] Mol Cell. 2012 Nov 30;48(4):532-46 [23084836] PLoS Genet. 2012;8(12):e1003146 [23284304] Carcinogenesis. 2013 Sep;34(9):1955-67 [23749751] Environ Mol Mutagen. 2013 Oct;54(8):659-67 [24038307] Toxicol Sci. 2013 Oct;135(2):369-79 [23853263] Epigenetics. 2013 Sep;8(9):962-9 [23867725] Gastroenterology. 2013 Dec;145(6):1424-35.e1-25 [24012984] Cancer Lett. 2014 Jan 28;342(2):223-30 [22306342] Toxicol Appl Pharmacol. 2014 Jan 1;274(1):63-77 [24183702] Cancer Lett. 2013 Jun 28;334(1):39-45 [23010082] Mol Carcinog. 2002 Oct;35(2):85-92 [12325038] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu044 ER - TY - JOUR T1 - Cumulative risk assessment for plasticizer-contaminated food using the hazard index approach. AN - 1518618334; 24631976 AB - Phthalates strongly and adversely affect reproduction, development and liver function. We did a cumulative risk assessment for simultaneous exposure to nine phthalates using the hazard index (HI) and the levels of nine phthalates in 1200 foodstuff samples. DEHP (di-2-ethylhexyl phthalate) present the highest level (mean: 0.443 mg/kg) in 1200 samples, and the highest average daily dose (ADD) was found in DEHP, ΣDBP(i + n) (the sum of dibutyl phthalate [DBP] isomers [DnBP + DiBP]) posed the highest risk potential of all the phthalates. In seven phthalates, the 95th percentiles of the ADDs for ΣDBP(i + n) in 0-6-yr-old children accounted for 91% (79-107%) of the tolerable daily intake, and the 95th percentiles of the HIs for the anti-androgenic effects of five phthalates in 0-3-yr-old children and 4-6-yr-old girls were >1. We conclude that the health of younger Taiwanese may be adversely affected by overexposure of phthalate-contaminated foods. Copyright © 2014 Elsevier Ltd. All rights reserved. JF - Environmental pollution (Barking, Essex : 1987) AU - Chang, J W AU - Chen, C Y AU - Yan, B R AU - Chang, M H AU - Tseng, S H AU - Kao, Y M AU - Chen, J C AU - Lee, C C AD - Research Center for Environmental Trace Toxic Substances, National Cheng Kung University, Tainan, Taiwan. ; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 704, Taiwan. ; Food and Drug Administration, Ministry of Health and Welfare, Executive Yuan, Taiwan. ; Department of Food Science and Nutrition, Meiho University, Pingtung, Taiwan. ; Research Center for Environmental Trace Toxic Substances, National Cheng Kung University, Tainan, Taiwan; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 704, Taiwan. Electronic address: cclee@mail.ncku.edu.tw. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 77 EP - 84 VL - 189 KW - Androgen Antagonists KW - 0 KW - Environmental Pollutants KW - Plasticizers KW - Dibutyl Phthalate KW - 2286E5R2KE KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - Index Medicus KW - Plasticizer-contaminated food KW - Average daily dose KW - Cumulative risk assessment KW - Phthalate esters KW - Hazard index KW - Young Adult KW - Humans KW - Diethylhexyl Phthalate -- analysis KW - Infant, Newborn KW - Aged KW - Diet -- statistics & numerical data KW - Child KW - Risk Assessment -- methods KW - Child, Preschool KW - Diethylhexyl Phthalate -- metabolism KW - Infant KW - No-Observed-Adverse-Effect Level KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Environmental Pollutants -- metabolism KW - Androgen Antagonists -- metabolism KW - Environmental Exposure -- statistics & numerical data KW - Food Contamination -- statistics & numerical data KW - Environmental Exposure -- analysis KW - Environmental Pollutants -- analysis KW - Androgen Antagonists -- analysis KW - Plasticizers -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518618334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.atitle=Cumulative+risk+assessment+for+plasticizer-contaminated+food+using+the+hazard+index+approach.&rft.au=Chang%2C+J+W%3BChen%2C+C+Y%3BYan%2C+B+R%3BChang%2C+M+H%3BTseng%2C+S+H%3BKao%2C+Y+M%3BChen%2C+J+C%3BLee%2C+C+C&rft.aulast=Chang&rft.aufirst=J&rft.date=2014-06-01&rft.volume=189&rft.issue=&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.issn=1873-6424&rft_id=info:doi/10.1016%2Fj.envpol.2014.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-06-20 N1 - Date created - 2014-04-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Erratum In: Environ Pollut. 2015 Jan;196:358 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.envpol.2014.02.005 ER - TY - JOUR T1 - The T-cell-dependent antibody response assay in nonclinical studies of pharmaceuticals and chemicals: study design, data analysis, interpretation. AN - 1518241949; 24566336 AB - The T-cell-dependent antibody response (TDAR) assay is a measure of immune function that is dependent upon the effectiveness of multiple immune processes, including antigen uptake and presentation, T cell help, B cell activation, and antibody production. It is used for risk and safety assessments, in conjunction with other toxicologic assessments, by the chemical and pharmaceutical industries, and research and regulatory agencies. It is also employed to evaluate investigational drug efficacy in animal pharmacology studies, provide evidence of biological impact in clinical trials, and evaluate immune function in patients with primary or secondary immunodeficiency diseases. Various immunization schemes, analytical methods, approaches to data analysis, and data interpretations are in use. This manuscript summarizes some recommended practices for the conduct and interpretation of the assay in animal studies. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Lebrec, Hervé AU - Molinier, Brigitte AU - Boverhof, Darrell AU - Collinge, Mark AU - Freebern, Wendy AU - Henson, Kristin AU - Mytych, Daniel T AU - Ochs, Hans D AU - Wange, Ronald AU - Yang, Yung AU - Zhou, Lei AU - Arrington, Joshua AU - Christin-Piché, Marie Soleil AU - Shenton, Jacintha AD - Amgen, Seattle, WA, USA. Electronic address: hlebrec@amgen.com. ; Sanofi-Aventis R&D, Montpellier, France. ; The Dow Chemical Company, Midland, MI, USA. ; Pfizer, Inc., Groton, CT, USA. ; Bristol-Myers Squibb Company, New Brunswick, NJ, USA. ; Novartis Institutes for Biomedical Research Inc., East Hanover, NJ, USA. ; Amgen, Thousand Oaks, CA, USA. ; Department of Pediatrics, University of Washington, and Seattle Children's Research Institute, Seattle, WA, USA. ; Food and Drug Administration, Silver Spring, MD, USA. ; Office of Pesticides Programs, US Environmental Protection Agency, Washington, DC, USA. ; Covance Inc., Madison, WI, USA. ; Charles River Laboratories, Montreal, Canada. ; MedImmune Ltd., Cambridge, UK. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 7 EP - 21 VL - 69 IS - 1 KW - Index Medicus KW - Immunotoxicity KW - TDAR KW - Nonclinical studies KW - Animals KW - Humans KW - Clinical Trials as Topic KW - Research Design KW - Drug Industry -- methods KW - Biological Assay -- methods KW - Antibody Formation -- immunology KW - Risk Assessment -- methods KW - T-Lymphocytes -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518241949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=The+T-cell-dependent+antibody+response+assay+in+nonclinical+studies+of+pharmaceuticals+and+chemicals%3A+study+design%2C+data+analysis%2C+interpretation.&rft.au=Lebrec%2C+Herv%C3%A9%3BMolinier%2C+Brigitte%3BBoverhof%2C+Darrell%3BCollinge%2C+Mark%3BFreebern%2C+Wendy%3BHenson%2C+Kristin%3BMytych%2C+Daniel+T%3BOchs%2C+Hans+D%3BWange%2C+Ronald%3BYang%2C+Yung%3BZhou%2C+Lei%3BArrington%2C+Joshua%3BChristin-Pich%C3%A9%2C+Marie+Soleil%3BShenton%2C+Jacintha&rft.aulast=Lebrec&rft.aufirst=Herv%C3%A9&rft.date=2014-06-01&rft.volume=69&rft.issue=1&rft.spage=7&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.02.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-22 N1 - Date created - 2014-04-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.02.008 ER - TY - JOUR T1 - Characterization of an anti-Bla g 1 scFv: epitope mapping and cross-reactivity. AN - 1514436205; 24667070 AB - Bla g 1 is a major allergen from Blatella germanica and one of the primary allergens used to assess cockroach allergen exposure. The epitope of an anti-Bla g 1 scFv was mapped in order to better understand cross reactivity with other group 1 cockroach allergens and patient IgE epitopes. X-ray crystallography was used to determine the structure of the scFv. The scFv epitope on Bla g 1 was located by alanine scanning site-directed mutagenesis and ELISA. Twenty-six rBla g 1-GST alanine mutants were evaluated for variations in binding to the scFv compared to the wild type allergen. Six mutants showed a significant difference in scFv binding affinity. These mutations clustered to form a discontinuous epitope mainly comprising two helices of Bla g 1. The allergen-scFv complex was modeled based on the results, and the epitope region was found to have low sequence similarity with Per a 1, especially among the residues identified as functionally important for the scFv binding to Bla g 1. Indeed, the scFv failed to bind Per a 1 in American cockroach extract. The scFv was unable to inhibit the binding of IgE antibodies from a highly cockroach allergic patient to Bla g 1. Based on the surface area of Bla g 1 occluded by the scFv, putative regions of patient IgE-Bla g 1 interactions can be inferred. This scFv could be best utilized as a capture antibody in an IgE detection ELISA, or to differentiate Bla g 1 from Per a 1 in environmental exposure assays. Published by Elsevier Ltd. JF - Molecular immunology AU - Mueller, Geoffrey A AU - Ankney, John A AU - Glesner, Jill AU - Khurana, Taruna AU - Edwards, Lori L AU - Pedersen, Lars C AU - Perera, Lalith AU - Slater, Jay E AU - Pomés, Anna AU - London, Robert E AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Electronic address: mueller3@niehs.nih.gov. ; National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. ; Indoor Biotechnologies, Inc., Charlottesville, VA 22903, USA. ; U.S. Food and Drug Administration, Bethesda, MD 20892, USA. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 200 EP - 207 VL - 59 IS - 2 KW - Allergens KW - 0 KW - Epitopes KW - Single-Chain Antibodies KW - allergen Bla g 1 KW - allergen Per a I KW - Immunoglobulin E KW - 37341-29-0 KW - Index Medicus KW - Allergen KW - Epitope KW - Structure KW - Bla g 1 KW - Cockroach KW - scFv KW - Animals KW - Immunoglobulin E -- immunology KW - Models, Molecular KW - Humans KW - Epitopes -- ultrastructure KW - Crystallography, X-Ray KW - Epitopes -- immunology KW - Binding Sites, Antibody -- immunology KW - Mutation KW - Epitope Mapping KW - Cross Reactions -- immunology KW - Allergens -- immunology KW - Single-Chain Antibodies -- immunology KW - Single-Chain Antibodies -- ultrastructure KW - Cockroaches -- immunology KW - Allergens -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1514436205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+immunology&rft.atitle=Characterization+of+an+anti-Bla+g+1+scFv%3A+epitope+mapping+and+cross-reactivity.&rft.au=Mueller%2C+Geoffrey+A%3BAnkney%2C+John+A%3BGlesner%2C+Jill%3BKhurana%2C+Taruna%3BEdwards%2C+Lori+L%3BPedersen%2C+Lars+C%3BPerera%2C+Lalith%3BSlater%2C+Jay+E%3BPom%C3%A9s%2C+Anna%3BLondon%2C+Robert+E&rft.aulast=Mueller&rft.aufirst=Geoffrey&rft.date=2014-06-01&rft.volume=59&rft.issue=2&rft.spage=200&rft.isbn=&rft.btitle=&rft.title=Molecular+immunology&rft.issn=1872-9142&rft_id=info:doi/10.1016%2Fj.molimm.2014.02.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-06-05 N1 - Date created - 2014-04-07 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Mar 23;276(12):9359-65 [11134039] Clin Exp Allergy. 2002 May;32(5):721-7 [11994096] Eur J Immunol. 2002 Aug;32(8):2156-62 [12209627] J Am Chem Soc. 2003 Feb 19;125(7):1731-7 [12580598] Annu Rev Immunol. 1984;2:67-101 [6085753] Science. 1990 Aug 17;249(4970):755-9 [1697101] J Allergy Clin Immunol. 1991 Feb;87(2):505-10 [1993810] J Allergy Clin Immunol. 1991 Feb;87(2):511-21 [1993811] Int Arch Allergy Immunol. 1995 Mar;106(3):250-7 [7534151] J Biol Chem. 1995 Aug 18;270(33):19563-8 [7642642] J Allergy Clin Immunol. 1996 Jul;98(1):172-80 [8765832] N Engl J Med. 1997 May 8;336(19):1356-63 [9134876] J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):563-70 [9802363] J Biol Chem. 1998 Nov 13;273(46):30801-7 [9804858] J Allergy Clin Immunol. 1999 May;103(5 Pt 1):859-64 [10329820] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Allergy Clin Immunol. 2005 Apr;115(4):803-9 [15806002] J Mol Biol. 2005 Apr 29;348(2):433-44 [15811379] Clin Exp Allergy. 2005 Aug;35(8):1040-8 [16120086] Protein Pept Lett. 2007;14(10):960-9 [18220993] J Allergy Clin Immunol. 2008 Mar;121(3):678-684.e2 [18255132] Methods Mol Biol. 2008;426:419-35 [18542881] J Biol Chem. 2008 Aug 15;283(33):22806-14 [18519566] J Biol Chem. 2009 Nov 13;284(46):31928-35 [19776018] Allergy. 2010 Nov;65(11):1414-22 [20560910] Ann Allergy Asthma Immunol. 2010 Nov;105(5):351-8 [21055660] PLoS One. 2011;6(7):e22223 [21789239] Allergy. 2011 Oct;66(10):1261-74 [21623828] J Biol Chem. 2012 Mar 2;287(10):7388-98 [22210776] J Mol Med (Berl). 2012 Jul;90(7):837-46 [22307521] J Immunol. 2012 Jul 15;189(2):679-88 [22706084] J Allergy Clin Immunol. 2013 Dec;132(6):1420-6 [23915714] Genome Biol Evol. 2013;5(12):2344-58 [24253356] Methods. 2014 Mar 1;66(1):3-21 [23891546] Arb Paul Ehrlich Inst Bundesinstitut Impfstoffe Biomed Arzneim Langen Hess. 2013;97:37-44 [24912311] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.molimm.2014.02.003 ER - TY - JOUR T1 - In vitro detection of cytotoxicity using FluoroJade-C. AN - 1511823201; 24462471 AB - We describe here a novel method for the determination of cytotoxicity in cell cultures using Fluoro-Jade C (FJ-C). FJ-C has been previously used for the assessment of neurodegeneration in fixed brain tissue samples, and has never been utilized in live cell cultures or in different types of cells other than neurons. In the present study we examined the utility of FJ-C for the determination of cytotoxicity in vitro. Various cell cultures were evaluated including neural stem cells, brain microvessel endothelial cells, and SH-SY5Y, PC12 and MDCK cells. Cytotoxicities induced by toxicants in cell cultures, as determined by the FJ-C labeling, were further confirmed by commonly used cytotoxicity assays. This in vitro approach is simple, fast, and sensitive and, thus, has the potential to augment if not replace currently used cell-based cytotoxicity assays. Published by Elsevier Ltd. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Gu, Qiang AU - Lantz-McPeak, Susan AU - Rosas-Hernandez, Hector AU - Cuevas, Elvis AU - Ali, Syed F AU - Paule, Merle G AU - Sarkar, Sumit AD - Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, United States. Electronic address: qiang.gu@fda.hhs.gov. ; Division of Neurotoxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, United States. Y1 - 2014/06// PY - 2014 DA - June 2014 SP - 469 EP - 472 VL - 28 IS - 4 KW - Fluoresceins KW - 0 KW - Fluorescent Dyes KW - fluoro-jade C KW - Cadmium KW - 00BH33GNGH KW - Index Medicus KW - Cell culture KW - Toxicity KW - Fluorescence microscopy KW - Rats KW - Animals KW - Cell Survival -- drug effects KW - Dose-Response Relationship, Drug KW - Cells, Cultured KW - Humans KW - Dogs KW - Mice KW - Fluorescent Dyes -- chemistry KW - Endothelial Cells -- drug effects KW - Fluoresceins -- chemistry KW - Neurons -- drug effects KW - Neural Stem Cells -- drug effects KW - Kidney -- cytology KW - Cadmium -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1511823201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=In+vitro+detection+of+cytotoxicity+using+FluoroJade-C.&rft.au=Gu%2C+Qiang%3BLantz-McPeak%2C+Susan%3BRosas-Hernandez%2C+Hector%3BCuevas%2C+Elvis%3BAli%2C+Syed+F%3BPaule%2C+Merle+G%3BSarkar%2C+Sumit&rft.aulast=Gu&rft.aufirst=Qiang&rft.date=2014-06-01&rft.volume=28&rft.issue=4&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2014.01.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-06-29 N1 - Date created - 2014-03-31 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2014.01.007 ER - TY - CPAPER T1 - Maternal and Neonatal Vaccination Protects Newborns from Severe Pertussis in a Nonhuman Primate Model T2 - 114th General Meeting of the American Society for Microbiology (ASM 2014) AN - 1518613994; 6284437 JF - 114th General Meeting of the American Society for Microbiology (ASM 2014) AU - Warfel, J AU - Papin, J AU - Wolf, R AU - Zimmerman, L AU - Merkel, T Y1 - 2014/05/17/ PY - 2014 DA - 2014 May 17 KW - Pertussis KW - Neonates KW - Vaccines KW - Vaccination KW - Primates UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518613994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=114th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2014%29&rft.atitle=Maternal+and+Neonatal+Vaccination+Protects+Newborns+from+Severe+Pertussis+in+a+Nonhuman+Primate+Model&rft.au=Warfel%2C+J%3BPapin%2C+J%3BWolf%2C+R%3BZimmerman%2C+L%3BMerkel%2C+T&rft.aulast=Warfel&rft.aufirst=J&rft.date=2014-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=114th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={673511F0-C86B-432F-A387-058032B8500B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Methylation in Salmonella Strains T2 - 114th General Meeting of the American Society for Microbiology (ASM 2014) AN - 1518611935; 6284566 JF - 114th General Meeting of the American Society for Microbiology (ASM 2014) AU - Hoffman, Maria Y1 - 2014/05/17/ PY - 2014 DA - 2014 May 17 KW - Anadromous species KW - Strains KW - Methylation KW - Salmonella UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518611935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=114th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2014%29&rft.atitle=Methylation+in+Salmonella+Strains&rft.au=Hoffman%2C+Maria&rft.aulast=Hoffman&rft.aufirst=Maria&rft.date=2014-05-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=114th+General+Meeting+of+the+American+Society+for+Microbiology+%28ASM+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/plan/start.aspx?mkey={673511F0-C86B-432F-A387-058032B8500B} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - JOUR T1 - CLPTM1L promotes growth and enhances aneuploidy in pancreatic cancer cells. AN - 1525765152; 24648346 AB - Genome-wide association studies (GWAS) of 10 different cancers have identified pleiotropic cancer predisposition loci across a region of chromosome 5p15.33 that includes the TERT and CLPTM1L genes. Of these, susceptibility alleles for pancreatic cancer have mapped to the CLPTM1L gene, thus prompting an investigation of the function of CLPTM1L in the pancreas. Immunofluorescence analysis indicated that CLPTM1L localized to the endoplasmic reticulum where it is likely embedded in the membrane, in accord with multiple predicted transmembrane domains. Overexpression of CLPTM1L enhanced growth of pancreatic cancer cells in vitro (1.3-1.5-fold; PDAY7 < 0.003) and in vivo (3.46-fold; PDAY68 = 0.039), suggesting a role in tumor growth; this effect was abrogated by deletion of two hydrophilic domains. Affinity purification followed by mass spectrometry identified an interaction between CLPTM1L and non-muscle myosin II (NMM-II), a protein involved in maintaining cell shape, migration, and cytokinesis. The two proteins colocalized in the cytoplasm and, after treatment with a DNA-damaging agent, at the centrosomes. Overexpression of CLPTM1L and depletion of NMM-II induced aneuploidy, indicating that CLPTM1L may interfere with normal NMM-II function in regulating cytokinesis. Immunohistochemical analysis revealed enhanced staining of CLPTM1L in human pancreatic ductal adenocarcinoma (n = 378) as compared with normal pancreatic tissue samples (n = 17; P = 1.7 × 10(-4)). Our results suggest that CLPTM1L functions as a growth-promoting gene in the pancreas and that overexpression may lead to an abrogation of normal cytokinesis, indicating that it should be considered as a plausible candidate gene that could explain the effect of pancreatic cancer susceptibility alleles on chr5p15.33. ©2014 American Association for Cancer Research. JF - Cancer research AU - Jia, Jinping AU - Bosley, Allen D AU - Thompson, Abbey AU - Hoskins, Jason W AU - Cheuk, Adam AU - Collins, Irene AU - Parikh, Hemang AU - Xiao, Zhen AU - Ylaya, Kris AU - Dzyadyk, Marta AU - Cozen, Wendy AU - Hernandez, Brenda Y AU - Lynch, Charles F AU - Loncarek, Jadranka AU - Altekruse, Sean F AU - Zhang, Lizhi AU - Westlake, Christopher J AU - Factor, Valentina M AU - Thorgeirsson, Snorri AU - Bamlet, William R AU - Hewitt, Stephen M AU - Petersen, Gloria M AU - Andresson, Thorkell AU - Amundadottir, Laufey T AD - Authors' Affiliations: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics; Pediatric Oncology Branch; Laboratory of Pathology; Division of Cancer Control and Population Sciences; Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda; Laboratory of Proteomics and Analytical Technologies, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research; Laboratory of Protein Dynamics and Signaling and Laboratory of Cell & Developmental Signaling, NCI-Frederick, Frederick, Maryland; Keck School of Medicine, University of Southern California, Los Angeles, California; University of Hawaii Cancer Center, Honolulu, Hawaii; Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa; and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. ; Authors' Affiliations: Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics; Pediatric Oncology Branch; Laboratory of Pathology; Division of Cancer Control and Population Sciences; Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda; Laboratory of Proteomics and Analytical Technologies, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research; Laboratory of Protein Dynamics and Signaling and Laboratory of Cell & Developmental Signaling, NCI-Frederick, Frederick, Maryland; Keck School of Medicine, University of Southern California, Los Angeles, California; University of Hawaii Cancer Center, Honolulu, Hawaii; Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa; and Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota amundadottirl@mail.nih.gov. Y1 - 2014/05/15/ PY - 2014 DA - 2014 May 15 SP - 2785 EP - 2795 VL - 74 IS - 10 KW - CLPTM1L protein, human KW - 0 KW - Membrane Proteins KW - Neoplasm Proteins KW - Myosin Type II KW - EC 3.6.1.- KW - Index Medicus KW - Heterografts KW - Myosin Type II -- metabolism KW - Animals KW - Aneuploidy KW - Cell Growth Processes -- physiology KW - Humans KW - HEK293 Cells KW - Mice, Nude KW - Mice KW - Cell Line, Tumor KW - Subcellular Fractions -- metabolism KW - Female KW - Neoplasm Proteins -- biosynthesis KW - Pancreatic Neoplasms -- pathology KW - Pancreatic Neoplasms -- metabolism KW - Carcinoma, Pancreatic Ductal -- metabolism KW - Membrane Proteins -- metabolism KW - Neoplasm Proteins -- genetics KW - Membrane Proteins -- biosynthesis KW - Carcinoma, Pancreatic Ductal -- pathology KW - Carcinoma, Pancreatic Ductal -- genetics KW - Pancreatic Neoplasms -- genetics KW - Membrane Proteins -- genetics KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1525765152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=CLPTM1L+promotes+growth+and+enhances+aneuploidy+in+pancreatic+cancer+cells.&rft.au=Jia%2C+Jinping%3BBosley%2C+Allen+D%3BThompson%2C+Abbey%3BHoskins%2C+Jason+W%3BCheuk%2C+Adam%3BCollins%2C+Irene%3BParikh%2C+Hemang%3BXiao%2C+Zhen%3BYlaya%2C+Kris%3BDzyadyk%2C+Marta%3BCozen%2C+Wendy%3BHernandez%2C+Brenda+Y%3BLynch%2C+Charles+F%3BLoncarek%2C+Jadranka%3BAltekruse%2C+Sean+F%3BZhang%2C+Lizhi%3BWestlake%2C+Christopher+J%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri%3BBamlet%2C+William+R%3BHewitt%2C+Stephen+M%3BPetersen%2C+Gloria+M%3BAndresson%2C+Thorkell%3BAmundadottir%2C+Laufey+T&rft.aulast=Jia&rft.aufirst=Jinping&rft.date=2014-05-15&rft.volume=74&rft.issue=10&rft.spage=2785&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/10.1158%2F0008-5472.CAN-13-3176 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-08-07 N1 - Date created - 2014-05-16 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Biochem Biophys Res Commun. 2001 Feb 2;280(4):1148-54 [11162647] Hum Mol Genet. 2013 Jun 15;22(12):2520-8 [23535824] Nat Biotechnol. 2002 May;20(5):473-7 [11981560] Science. 2003 Mar 14;299(5613):1743-7 [12637748] Cell. 2004 Apr 30;117(3):361-72 [15109496] Cancer Genet Cytogenet. 2004 Oct 15;154(2):99-109 [15474144] J Cell Biol. 1977 Jul;74(1):251-63 [141455] Science. 1987 May 29;236(4805):1086-91 [3576222] Science. 1994 Dec 23;266(5193):2011-5 [7605428] Cell. 1995 Sep 22;82(6):949-57 [7553855] J Cell Sci. 2006 Oct 15;119(Pt 20):4342-52 [17038547] Methods. 2007 Apr;41(4):460-74 [17367718] BMC Cancer. 2007;7:226 [18088415] Cancer Genet Cytogenet. 2008 Apr 1;182(1):1-11 [18328944] J Cell Sci. 2008 Sep 1;121(Pt 17):2860-70 [18697832] Nat Genet. 2008 Dec;40(12):1407-9 [18978787] Nat Genet. 2008 Dec;40(12):1404-6 [18978790] Nat Genet. 2009 Feb;41(2):221-7 [19151717] Cancer Res. 2009 Apr 1;69(7):2950-5 [19276352] Nat Genet. 2009 Aug;41(8):909-14 [19578363] Nat Genet. 2009 Aug;41(8):899-904 [19578367] Cancer Res. 2009 Aug 15;69(16):6633-41 [19654303] Nat Rev Mol Cell Biol. 2009 Nov;10(11):778-90 [19851336] PLoS Genet. 2009 Nov;5(11):e1000719 [19911042] Am J Hum Genet. 2009 Nov;85(5):679-91 [19836008] Nat Genet. 2010 Mar;42(3):224-8 [20101243] Nat Cell Biol. 2010 Apr;12(4):362-71 [20208530] Nat Genet. 2010 Jul;42(7):604-7 [20543847] Nature. 2010 Jul 1;466(7302):68-76 [20562859] Nat Genet. 2010 Nov;42(11):978-84 [20972438] J Proteome Res. 2010 Dec 3;9(12):6696-704 [20968308] Nat Genet. 2011 Aug;43(8):785-91 [21743467] Biochem Soc Trans. 2011 Oct;39(5):1115-9 [21936774] Biochem Soc Trans. 2011 Oct;39(5):1131-5 [21936777] Nat Genet. 2011 Dec;43(12):1210-4 [22037553] PLoS One. 2012;7(3):e32667 [22412903] PLoS One. 2012;7(6):e36116 [22675468] J Natl Cancer Inst. 2012 Jun 6;104(11):840-54 [22523397] Arch Dermatol Res. 2013 Jan;305(1):49-52 [22893025] PLoS One. 2012;7(12):e52598 [23300716] Nat Genet. 2013 Apr;45(4):371-84, 384e1-2 [23535731] Cold Spring Harb Perspect Biol. 2013 Apr;5(4):a013227 [23545422] Bioinformatics. 2001 Dec;17(12):1228-9 [11751233] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1158/0008-5472.CAN-13-3176 ER - TY - JOUR T1 - Breast cancer risk after radiotherapy for heritable and non-heritable retinoblastoma: a US-UK study AN - 1534855121; 19881880 AB - Background: Retinoblastoma is a rare childhood eye cancer caused by germline or somatic mutations in the RB1 gene. Previous studies observed elevated breast cancer risk among retinoblastoma survivors. However, there has been no research on breast cancer risk in relation to radiation (primarily scatter radiation from the primary treatment) and genetic susceptibility of retinoblastoma survivors. Methods: Two groups of retinoblastoma survivors from the US and UK were selected, and breast cancer risk analysed using a case-control methodology, nesting within the respective cohorts, matching on heritability (that is to say, having bilateral retinoblastoma or being unilateral cases with at least one relative with retinoblastoma), and using exact statistical methods. There were a total of 31 cases and 77 controls. Results: Overall there was no significant variation of breast cancer risk with dose (P>0.5). However, there was a pronounced and significant (P=0.047) increase in the risk of breast cancer with increasing radiation dose for non-heritable retinoblastoma patients and a slight and borderline significant (P=0.072) decrease in risk of breast cancer with increasing radiation dose for heritable retinoblastoma patients, implying significant (P=0.024) heterogeneity in radiation risk between the heritable and non-heritable retinoblastoma groups; this was unaffected by the blindness status. There was no significant effect of any type of alkylating-agent chemotherapy on breast cancer risk (P>0.5). Conclusions: There is significant radiation-related risk of breast cancer for non-heritable retinoblastoma survivors but no excess risk for heritable retinoblastoma survivors, and no significant risk overall. However, these results are based on very small numbers of cases; therefore, they must be interpreted with caution. JF - British Journal of Cancer AU - Little, M P AU - Schaeffer, M L AU - Reulen, R C AU - Abramson, D H AU - Stovall, M AU - Weathers, R AU - de Vathaire, F AU - Diallo, I AU - Seddon, J M AU - Hawkins, M M AU - Tucker, M A AU - Kleinerman, R A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA Y1 - 2014/05/13/ PY - 2014 DA - 2014 May 13 SP - 2623 EP - 2632 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 110 IS - 10 SN - 0007-0920, 0007-0920 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534855121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Breast+cancer+risk+after+radiotherapy+for+heritable+and+non-heritable+retinoblastoma%3A+a+US-UK+study&rft.au=Little%2C+M+P%3BSchaeffer%2C+M+L%3BReulen%2C+R+C%3BAbramson%2C+D+H%3BStovall%2C+M%3BWeathers%2C+R%3Bde+Vathaire%2C+F%3BDiallo%2C+I%3BSeddon%2C+J+M%3BHawkins%2C+M+M%3BTucker%2C+M+A%3BKleinerman%2C+R+A&rft.aulast=Little&rft.aufirst=M&rft.date=2014-05-13&rft.volume=110&rft.issue=10&rft.spage=2623&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2014.193 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Last updated - 2014-06-12 DO - http://dx.doi.org/10.1038/bjc.2014.193 ER - TY - CPAPER T1 - Localization of ultrasound induced in-vivo neurostimulation in the mouse model T2 - 167th Meeting of the Acoustical Society of America AN - 1548628097; 6291538 JF - 167th Meeting of the Acoustical Society of America AU - King, Randy Y1 - 2014/05/05/ PY - 2014 DA - 2014 May 05 KW - Animal models KW - Ultrasound UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1548628097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=167th+Meeting+of+the+Acoustical+Society+of+America&rft.atitle=Localization+of+ultrasound+induced+in-vivo+neurostimulation+in+the+mouse+model&rft.au=King%2C+Randy&rft.aulast=King&rft.aufirst=Randy&rft.date=2014-05-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=167th+Meeting+of+the+Acoustical+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://acousticalsociety.org/sites/default/files/docs/fullprogram.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-30 N1 - Last updated - 2014-07-28 ER - TY - RPRT T1 - Investigation of Infectious Disease Risks Associated With a Nontransplant Anatomical Donation Center - Arizona, 2014 AN - 1528150459; 24785985 AB - CDC is investigating reports of potential occupational exposure to human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), and Mycobacterium tuberculosis among workers performing preparation and dissection procedures on human nontransplant anatomical materials at a nontransplant anatomical donation center in Arizona. CDC is working with Arizona public health officials to inform persons exposed to these potentially infected materials. Nontransplant anatomical centers around the United States process thousands of donated cadavers annually. Arizona public health officials have offered former workers at the center cost-free testing for HIV, HBV, and HCV, and M. tuberculosis infection as well as counseling regarding these infections. JF - MMWR. Morbidity and Mortality Weekly Report AU - de Perio, Marie A, MD AU - Bernard, Bruce P, MD AU - Delaney, Lisa J, MS AU - Pesik, Nicki, MD AU - Cohen, Nicole J, MD Y1 - 2014/05/02/ PY - 2014 DA - 2014 May 02 SP - 384 EP - 5 CY - Atlanta PB - U.S. Center for Disease Control KW - Public Health And Safety KW - Human exposure KW - Public health KW - Human immunodeficiency virus--HIV KW - Viral infections KW - Tuberculosis KW - Arizona KW - United States KW - Centers for Disease Control & Prevention (U.S.) KW - Arizona -- epidemiology KW - Humans KW - Tuberculosis -- epidemiology KW - Hepatitis C -- epidemiology KW - HIV Infections -- epidemiology KW - Risk Assessment KW - Hepatitis B -- epidemiology KW - Communicable Diseases -- epidemiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Tissue Banks UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1528150459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.atitle=Investigation+of+Infectious+Disease+Risks+Associated+With+a+Nontransplant+Anatomical+Donation+Center+-+Arizona%2C+2014&rft.au=de+Perio%2C+Marie+A%2C+MD%3BBernard%2C+Bruce+P%2C+MD%3BDelaney%2C+Lisa+J%2C+MS%3BPesik%2C+Nicki%2C+MD%3BCohen%2C+Nicole+J%2C+MD&rft.aulast=de+Perio&rft.aufirst=Marie&rft.date=2014-05-02&rft.volume=63&rft.issue=17&rft.spage=384&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.issn=01492195&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Name - Centers for Disease Control & Prevention--CDC N1 - Copyright - Copyright U.S. Center for Disease Control May 2, 2014 N1 - Document feature - References N1 - Last updated - 2014-06-07 ER - TY - CPAPER T1 - Novel in vivo approaches for the study of immune responses T2 - 2014 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2014) AN - 1518611546; 6280547 JF - 2014 Annual Meeting of the American Association of Immunologists (IMMUNOLOGY 2014) AU - Ragheb, Jack Y1 - 2014/05/02/ PY - 2014 DA - 2014 May 02 KW - Immune response UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518611546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2014%29&rft.atitle=Novel+in+vivo+approaches+for+the+study+of+immune+responses&rft.au=Ragheb%2C+Jack&rft.aulast=Ragheb&rft.aufirst=Jack&rft.date=2014-05-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Meeting+of+the+American+Association+of+Immunologists+%28IMMUNOLOGY+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.immunology2014.org/Program/index.html?loc=nav LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - JOUR T1 - Alcohol consumption and social network ties among adolescents: Evidence from Add Health AN - 1832259452; 20246026 AB - Although many studies have estimated the influence of peers on risky health behaviors, few have estimated the gains that adolescents receive from such behaviors, particularly in terms of social payoffs for complying with peer behavior. In this paper, we explore the extent to which alcohol consumption increases popularity of adolescents. Using data from a nationally-representative sample of adolescents, we estimate endogeneity-corrected models with school-level fixed effects to identify the effect of alcohol consumption on social network ties. We find that alcohol consumption leads to an increase in popularity, with the largest gains experienced by white males and females. Our results provide new evidence on the motivation behind adolescent drinking and have important implications for substance abuse interventions. JF - Addictive Behaviors AU - Ali, Mir M AU - Amialchuk, Aliaksandr AU - Nikaj, Silda AD - Substance Abuse & Mental Health Services AdministrationAnalysis & Services Research Branch1 Choke Cherry RoadRockville, MD 20857, mir.ali@samhsa.hhs.gov Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 918 EP - 922 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 39 IS - 5 SN - 0306-4603, 0306-4603 KW - Biotechnology and Bioengineering Abstracts KW - Social networks KW - Alcohol KW - Adolescents KW - Data processing KW - Motivation KW - Adolescence KW - Drinking behavior KW - Drug abuse KW - Ethanol KW - Social interactions KW - Models KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1832259452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+Behaviors&rft.atitle=Alcohol+consumption+and+social+network+ties+among+adolescents%3A+Evidence+from+Add+Health&rft.au=Ali%2C+Mir+M%3BAmialchuk%2C+Aliaksandr%3BNikaj%2C+Silda&rft.aulast=Ali&rft.aufirst=Mir&rft.date=2014-05-01&rft.volume=39&rft.issue=5&rft.spage=918&rft.isbn=&rft.btitle=&rft.title=Addictive+Behaviors&rft.issn=03064603&rft_id=info:doi/10.1016%2Fj.addbeh.2013.11.030 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-10-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Data processing; Motivation; Adolescence; Drinking behavior; Drug abuse; Models; Social interactions; Ethanol DO - http://dx.doi.org/10.1016/j.addbeh.2013.11.030 ER - TY - JOUR T1 - Investigating the importance of sediment resuspension in Alexandrium fundyense cyst population dynamics in the Gulf of Maine AN - 1756510397; 2016-006245 AB - Cysts of Alexandrium fundyense, a dinoflagellate that causes toxic algal blooms in the Gulf of Maine, spend the winter as dormant cells in the upper layer of bottom sediment or the bottom nepheloid layer and germinate in spring to initiate new blooms. Erosion measurements were made on sediment cores collected at seven stations in the Gulf of Maine in the autumn of 2011 to explore if resuspension (by waves and currents) could change the distribution of over-wintering cysts from patterns observed in the previous autumn; or if resuspension could contribute cysts to the water column during spring when cysts are viable. The mass of sediment eroded from the core surface at 0.4 Pa ranged from 0.05 kg m (super -2) near Grand Manan Island, to 0.35 kg m (super -2) in northern Wilkinson Basin. The depth of sediment eroded ranged from about 0.05 mm at a station with sandy sediment at 70 m water depth on the western Maine shelf, to about 1.2 mm in clayey-silt sediment at 250 m water depth in northern Wilkinson Basin. The sediment erodibility measurements were used in a sediment-transport model forced with modeled waves and currents for the period October 1, 2010 to May 31, 2011 to predict resuspension and bed erosion. The simulated spatial distribution and variation of bottom shear stress was controlled by the strength of the semi-diurnal tidal currents, which decrease from east to west along the Maine coast, and oscillatory wave-induced currents, which are strongest in shallow water. Simulations showed occasional sediment resuspension along the central and western Maine coast associated with storms, steady resuspension on the eastern Maine shelf and in the Bay of Fundy associated with tidal currents, no resuspension in northern Wilkinson Basin, and very small resuspension in western Jordan Basin. The sediment response in the model depended primarily on the profile of sediment erodibility, strength and time history of bottom stress, consolidation time scale, and the current in the water column. Based on analysis of wave data from offshore buoys from 1996 to 2012, the number of wave events inducing a bottom shear stress large enough to resuspend sediment at 80 m ranged from 0 to 2 in spring (April and May) and 0 to 10 in winter (October through March). Wave-induced resuspension is unlikely in water greater than about 100 m deep. The observations and model results suggest that a millimeter or so of sediment and associated cysts may be mobilized in both winter and spring, and that the frequency of resuspension will vary interannually. Depending on cyst concentration in the sediment and the vertical distribution in the water column, these events could result in a concentration in the water column of at least 10 (super 4) cysts m (super -3) . In some years, resuspension events could episodically introduce cysts into the water column in spring, where germination is likely to be facilitated at the time of bloom formation. An assessment of the quantitative effects of cyst resuspension on bloom dynamics in any particular year requires more detailed investigation. Abstract Copyright (2014) Elsevier, B.V. JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Butman, Bradford AU - Aretxabaleta, Alfredo L AU - Dickhudt, Patrick J AU - Dalyander, P Soupy AU - Sherwood, Christopher R AU - Anderson, Donald M AU - Keafer, Bruce A AU - Signell, Richard P Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 79 EP - 95 PB - Elsevier, Oxford VL - 103 SN - 0967-0645, 0967-0645 KW - Plantae KW - annual variations KW - sediment transport KW - shear stress KW - Dinoflagellata KW - suspension KW - ecosystems KW - algae KW - environmental effects KW - marine sediments KW - toxicity KW - transport KW - palynomorphs KW - sediments KW - natural hazards KW - ocean floors KW - North Atlantic KW - Gulf of Maine KW - erodibility KW - Atlantic Ocean KW - algal blooms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1756510397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Investigating+the+importance+of+sediment+resuspension+in+Alexandrium+fundyense+cyst+population+dynamics+in+the+Gulf+of+Maine&rft.au=Butman%2C+Bradford%3BAretxabaleta%2C+Alfredo+L%3BDickhudt%2C+Patrick+J%3BDalyander%2C+P+Soupy%3BSherwood%2C+Christopher+R%3BAnderson%2C+Donald+M%3BKeafer%2C+Bruce+A%3BSignell%2C+Richard+P&rft.aulast=Butman&rft.aufirst=Bradford&rft.date=2014-05-01&rft.volume=103&rft.issue=&rft.spage=79&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/10.1016%2Fj.dsr2.2013.10.011 L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 75 N1 - Document feature - illus. incl. 2 tables, sketch map N1 - Last updated - 2016-01-14 N1 - SubjectsTermNotLitGenreText - algae; algal blooms; annual variations; Atlantic Ocean; Dinoflagellata; ecosystems; environmental effects; erodibility; Gulf of Maine; marine sediments; natural hazards; North Atlantic; ocean floors; palynomorphs; Plantae; sediment transport; sediments; shear stress; suspension; toxicity; transport DO - http://dx.doi.org/10.1016/j.dsr2.2013.10.011 ER - TY - JOUR T1 - Near-bottom circulation and dispersion of sediment containing Alexandrium fundyense cysts in the Gulf of Maine during 2010-2011 AN - 1756509200; 2016-006246 AB - The life cycle of Alexandrium fundyense in the Gulf of Maine includes a dormant cyst stage that spends the winter predominantly in the bottom sediment. Wave-current bottom stress caused by storms and tides induces resuspension of cyst-containing sediment during winter and spring. Resuspended sediment could be transported by water flow to different locations in the Gulf and the redistribution of sediment containing A. fundyense cysts could alter the spatial and temporal manifestation of its spring bloom. The present study evaluates model near-bottom flow during storms, when sediment resuspension and redistribution are most likely to occur, between October and May when A. fundyense cells are predominantly in cyst form. Simulated water column sediment (mud) concentrations from representative locations of the Gulf are used to initialize particle tracking simulations for the period October 2010-May 2011. Particles are tracked in full three-dimensional model solutions including a sinking velocity characteristic of cyst and aggregated mud settling (0.1 mm s (super -1) ). Although most of the material was redeposited near the source areas, small percentages of total resuspended sediment from some locations in the western ( approximately 4%) and eastern (2%) Maine shelf and the Bay of Fundy (1%) traveled distances longer than 100 km before resettling. The redistribution changed seasonally and was sensitive to the prescribed sinking rate. Estimates of the amount of cysts redistributed with the sediment were small compared to the inventory of cysts in the upper few centimeters of sediment but could potentially have more relevance immediately after deposition. Abstract Copyright (2014) Elsevier, B.V. JF - Deep-Sea Research. Part II: Topical Studies in Oceanography AU - Aretxabaleta, Alfredo L AU - Butman, Bradford AU - Signell, Richard P AU - Dalyander, P Soupy AU - Sherwood, Christopher R AU - Sheremet, Vitalii A AU - McGillicuddy, Dennis J, Jr Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 96 EP - 111 PB - Elsevier, Oxford VL - 103 SN - 0967-0645, 0967-0645 KW - settling KW - shear stress KW - ecosystems KW - algae KW - environmental effects KW - marine sediments KW - toxicity KW - digital simulation KW - sediments KW - velocity KW - storms KW - ocean floors KW - currents KW - Plantae KW - numerical models KW - three-dimensional models KW - Dinoflagellata KW - suspension KW - bottom currents KW - ocean currents KW - models KW - palynomorphs KW - natural hazards KW - North Atlantic KW - Gulf of Maine KW - microfossils KW - Atlantic Ocean KW - algal blooms KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1756509200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.atitle=Near-bottom+circulation+and+dispersion+of+sediment+containing+Alexandrium+fundyense+cysts+in+the+Gulf+of+Maine+during+2010-2011&rft.au=Aretxabaleta%2C+Alfredo+L%3BButman%2C+Bradford%3BSignell%2C+Richard+P%3BDalyander%2C+P+Soupy%3BSherwood%2C+Christopher+R%3BSheremet%2C+Vitalii+A%3BMcGillicuddy%2C+Dennis+J%2C+Jr&rft.aulast=Aretxabaleta&rft.aufirst=Alfredo&rft.date=2014-05-01&rft.volume=103&rft.issue=&rft.spage=96&rft.isbn=&rft.btitle=&rft.title=Deep-Sea+Research.+Part+II%3A+Topical+Studies+in+Oceanography&rft.issn=09670645&rft_id=info:doi/10.1016%2Fj.dsr2.2013.11.003 L2 - http://www.sciencedirect.com/science/journal/09670645 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. Reference includes data from CAPCAS, Elsevier Scientific Publishers, Amsterdam, Netherlands N1 - Date revised - 2016-01-01 N1 - Number of references - 52 N1 - Document feature - illus. incl. 3 tables, sketch map N1 - Last updated - 2016-01-14 N1 - SubjectsTermNotLitGenreText - algae; algal blooms; Atlantic Ocean; bottom currents; currents; digital simulation; Dinoflagellata; ecosystems; environmental effects; Gulf of Maine; marine sediments; microfossils; models; natural hazards; North Atlantic; numerical models; ocean currents; ocean floors; palynomorphs; Plantae; sediments; settling; shear stress; storms; suspension; three-dimensional models; toxicity; velocity DO - http://dx.doi.org/10.1016/j.dsr2.2013.11.003 ER - TY - JOUR T1 - Assessing the effect of laser beam width on quantitative evaluation of optical properties of intraocular lens implants AN - 1660397727; 21101489 AB - The design and manufacture of intraocular lenses (IOLs) depend upon the identification and quantitative preclinical evaluation of key optical properties and environmental parameters. The confocal laser method (CLM) is a new technique for measuring IOL optical properties, such as dioptric power, optical quality, refractive index, and geometrical parameters. In comparison to competing systems, the CLM utilizes a fiber-optic confocal laser design that significantly improves the resolution, accuracy, and repeatability of optical measurements. Here, we investigate the impact of changing the beam diameter on the CLM platform for the evaluation of IOL dioptric powers. Due to the Gaussian intensity profile of the CLM laser beam, the changes in focal length and dioptric power associated with changes in beam diameter are well within the tolerances specified in the ISO IOL standard. These results demonstrate some of the advanced potentials of the CLM toward more effectively and quantitatively evaluating IOL optical properties. JF - Journal of Biomedical Optics AU - Walker, Bennett N AU - James, Robert H AU - Chakravarty, Aurin AU - Calogero, Don AU - Ilev, Ilko K AD - Optical Therapeutics and Medical Nanophotonics Laboratory, Office of Science and Engineering Laboratories, U.S. Food and Drug Administration, Silver Spring, Maryland 20993 Y1 - 2014/05// PY - 2014 DA - May 2014 PB - SPIE - The International Society for Optics and Photonics, P.O. BOX 10 Bellingham WA 98227-0010 United States VL - 19 IS - 5 SN - 1083-3668, 1083-3668 KW - Biotechnology and Bioengineering Abstracts KW - Lasers KW - Optical properties KW - Intraocular lenses KW - Optics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1660397727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Optics&rft.atitle=Assessing+the+effect+of+laser+beam+width+on+quantitative+evaluation+of+optical+properties+of+intraocular+lens+implants&rft.au=Walker%2C+Bennett+N%3BJames%2C+Robert+H%3BChakravarty%2C+Aurin%3BCalogero%2C+Don%3BIlev%2C+Ilko+K&rft.aulast=Walker&rft.aufirst=Bennett&rft.date=2014-05-01&rft.volume=19&rft.issue=5&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Optics&rft.issn=10833668&rft_id=info:doi/10.1117%2F1.JBO.19.5.055004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-03-01 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Optics; Optical properties; Lasers DO - http://dx.doi.org/10.1117/1.JBO.19.5.055004 ER - TY - JOUR T1 - PSP toxin levels and plankton community composition and abundance in size-fractionated vertical profiles during spring/summer blooms of the toxic dinoflagellate Alexandrium fundyense in the Gulf of Maine and on Georges Bank, 2007, 2008, and 2010: 1. Toxin levels AN - 1647002052; 21255469 AB - As part of the NOAA ECOHAB funded Gulf of Maine Toxicity (GOMTOX) 1 project, we determined Alexandrium fundyense abundance, paralytic shellfish poisoning (PSP) toxin composition, and concentration in quantitatively-sampled size-fractionated (20-64, 64-100, 100-200, 200-500, and >500 mu m) particulate water samples, and the community composition of potential grazers of A. fundyense in these size fractions, at multiple depths (typically 1, 10, 20m, and near-bottom) during 10 large-scale sampling cruises during the A. fundyense bloom season (May-August) in the coastal Gulf of Maine and on Georges Bank in 2007, 2008, and 2010. Our findings were as follows: (1) when all sampling stations and all depths were summed by year, the majority (94% plus or minus 4%) of total PSP toxicity was contained in the 20-64 mu m size fraction; (2) when further analyzed by depth, the 20-64 mu m size fraction was the primary source of toxin for 97% of the stations and depths samples over three years; (3) overall PSP toxin profiles were fairly consistent during the three seasons of sampling with gonyautoxins (1, 2, 3, and 4) dominating (90.7% plus or minus 5.5%), followed by the carbamate toxins saxitoxin (STX) and neosaxitoxin (NEO) (7.7% plus or minus 4.5%), followed by n-sulfocarbamoyl toxins (C1 and 2, GTX5) (1.3% plus or minus 0.6%), followed by all decarbamoyl toxins (dcSTX, dcNEO, dcGTX2&3) (<1%), although differences were noted between PSP toxin compositions for nearshore coastal Gulf of Maine sampling stations compared to offshore Georges Bank sampling stations for 2 out of 3 years; (4) surface cell counts of A. fundyense were a fairly reliable predictor of the presence of toxins throughout the water column; and (5) nearshore surface cell counts of A. fundyense in the coastal Gulf of Maine were not a reliable predictor of A. fundyense populations offshore on Georges Bank for 2 out of the 3 years sampled. JF - Deep Sea Research (Part II, Topical Studies in Oceanography) AU - Deeds, Jonathan R AU - Petitpas, Christian M AU - Shue, Vangie AU - White, Kevin D AU - Keafer, Bruce A AU - McGillicuddy, Dennis J, Jr AU - Milligan, Peter J AU - Anderson, Donald M AU - Turner, Jefferson T AD - US FDA Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, USA Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 329 EP - 349 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 103 SN - 0967-0645, 0967-0645 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Ecology Abstracts; ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts; Toxicology Abstracts KW - Harmful algal bloom KW - PSP toxins KW - Alexandrium sp. KW - Vectorial intoxication KW - Gulf of Maine KW - Georges Bank KW - Cell surface KW - Algal blooms KW - Toxicants KW - ANW, USA, Maine Gulf KW - Abundance KW - Phytoplankton KW - Spring KW - Water column KW - Saxitoxin KW - Dinoflagellates KW - Deep sea KW - Sampling KW - Paralytic shellfish poisoning KW - Size KW - Marine KW - ANW, Atlantic, Georges Bank KW - gonyautoxin KW - Oceanography KW - Toxicity KW - Toxins KW - Community composition KW - Alexandrium fundyense KW - Plankton KW - Population number KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q1 08463:Habitat community studies KW - X 24370:Natural Toxins KW - D 04040:Ecosystem and Ecology Studies KW - K 03450:Ecology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647002052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep+Sea+Research+%28Part+II%2C+Topical+Studies+in+Oceanography%29&rft.atitle=PSP+toxin+levels+and+plankton+community+composition+and+abundance+in+size-fractionated+vertical+profiles+during+spring%2Fsummer+blooms+of+the+toxic+dinoflagellate+Alexandrium+fundyense+in+the+Gulf+of+Maine+and+on+Georges+Bank%2C+2007%2C+2008%2C+and+2010%3A+1.+Toxin+levels&rft.au=Deeds%2C+Jonathan+R%3BPetitpas%2C+Christian+M%3BShue%2C+Vangie%3BWhite%2C+Kevin+D%3BKeafer%2C+Bruce+A%3BMcGillicuddy%2C+Dennis+J%2C+Jr%3BMilligan%2C+Peter+J%3BAnderson%2C+Donald+M%3BTurner%2C+Jefferson+T&rft.aulast=Deeds&rft.aufirst=Jonathan&rft.date=2014-05-01&rft.volume=103&rft.issue=&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Deep+Sea+Research+%28Part+II%2C+Topical+Studies+in+Oceanography%29&rft.issn=09670645&rft_id=info:doi/10.1016%2Fj.dsr2.2013.04.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 34 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Algal blooms; Community composition; Toxicants; Phytoplankton; Spring; Toxicity; Paralytic shellfish poisoning; Size; Population number; Cell surface; Abundance; gonyautoxin; Oceanography; Toxins; Water column; Dinoflagellates; Saxitoxin; Deep sea; Sampling; Plankton; Alexandrium fundyense; ANW, Atlantic, Georges Bank; ANW, USA, Maine Gulf; Marine DO - http://dx.doi.org/10.1016/j.dsr2.2013.04.013 ER - TY - JOUR T1 - Onboard screening dockside testing as a new means of managing paralytic shellfish poisoning risks in federally closed waters AN - 1647001677; 21255474 AB - Paralytic shellfish poisoning (PSP) is the foodborne intoxication associated with the consumption of seafood contaminated with naturally occurring neurotoxins known as paralytic shellfish toxins. To protect public health from this potentially fatal syndrome, harvesting closures are implemented when toxins exceed the regulatory action level. Traditional monitoring programs established by state shellfish authorities allow for timely closures in state waters with minimal negative impacts on industry. However, such monitoring programs are not feasible in federal offshore waters given their distance from shore and the range of their spatial coverage. Thus innovative management strategies were investigated for these offshore resources. Georges Bank, an offshore resource with an estimated market value of more than $3 billion in Atlantic surfclams and ocean quahogs, has been closed to harvesting following a temporary ban in 1989 and a subsequent indefinite closure in 1990 due to the risk of PSP. As a means of managing this risk and allowing harvest of safe shellfish from this important resource, the Onboard Screening Dockside Testing Protocol (referred to as the Protocol) was developed by the US Food and Drug Administration (FDA), National Marine Fisheries Service (NMFS), state shellfish control authorities, and industry. The Protocol, which sets forth control measures to ensure product safety and public health protection, was endorsed by the Interstate Shellfish Sanitation Conference (ISSC) for pilot testing. Briefly, the pilot study Protocol required that (1) the fishing vessel receive a permit from NMFS to harvest in closed waters, (2) a minimum of five shellfish samples per intended harvest lot be tested for PSP toxins onboard, and (3) harvesting only occur when the samples tested from the intended fishing area are negative using the Jellett Rapid Tests or Abraxis Shipboard ELISA kits. Finally, product landed under the Protocol was confirmed to be safe for consumption using the mouse bioassay (MBA) prior to its introduction into commerce. This paper presents data from the pilot study, with primary focus on the advantages and challenges of the field kits employed onboard compared to the dockside MBA, which has served as the longstanding regulatory method for PSP toxins. In 2010 alone, the successful pilot study resulted in the safe harvest of over $2.7 million worth of surfclams in an area that has otherwise been unavailable for decades. Due to the success of this pilot study, the Protocol was adopted into the National Shellfish Sanitation Program Model Ordinance as an approved marine biotoxin control strategy for use in federal waters at the 2011 ISSC Biennial Meeting. In January 2013 a portion of Georges Bank was reopened for the harvest of Atlantic surfclams and ocean quahogs to fishermen following the Protocol. JF - Deep Sea Research (Part II, Topical Studies in Oceanography) AU - DeGrasse, Stacey AU - Conrad, Stephen AU - DiStefano, Paul AU - Vanegas, Camilo AU - Wallace, David AU - Jensen, Pete AU - Hickey, JMichael AU - Cenci, Florence AU - Pitt, Jaclyn AU - Deardorff, Dave AU - Rubio, Fernando AU - Easy, Dorothy AU - Donovan, Mary Anne AU - Laycock, Maurice AU - Rouse, Debbie AU - Mullen, John AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, 5100 Paint Branch Parkway, College Park, MD 20740, United States Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 288 EP - 300 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 103 SN - 0967-0645, 0967-0645 KW - Meteorological & Geoastrophysical Abstracts; Health & Safety Science Abstracts; Risk Abstracts; ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts KW - Field kits KW - Georges Bank KW - Management KW - Offshore waters KW - Paralytic shellfish poisoning KW - Quahogs KW - Saxitoxin KW - Surfclams KW - Intoxication KW - Toxicants KW - Public health KW - Fishing KW - Sanitation KW - Fishery management KW - Fisheries KW - ELISA KW - Deep sea KW - Commerce KW - Seafood KW - Drugs KW - Innovations KW - Screening KW - Marine KW - ANW, Atlantic, Georges Bank KW - Poisoning KW - Toxins KW - Risk management KW - Oceans KW - Shellfish KW - Harvesting KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - Q1 08463:Habitat community studies KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - M2 551.462:Submarine Topography/Bottom Forms/Sea-Floor Features (551.462) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647001677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep+Sea+Research+%28Part+II%2C+Topical+Studies+in+Oceanography%29&rft.atitle=Onboard+screening+dockside+testing+as+a+new+means+of+managing+paralytic+shellfish+poisoning+risks+in+federally+closed+waters&rft.au=DeGrasse%2C+Stacey%3BConrad%2C+Stephen%3BDiStefano%2C+Paul%3BVanegas%2C+Camilo%3BWallace%2C+David%3BJensen%2C+Pete%3BHickey%2C+JMichael%3BCenci%2C+Florence%3BPitt%2C+Jaclyn%3BDeardorff%2C+Dave%3BRubio%2C+Fernando%3BEasy%2C+Dorothy%3BDonovan%2C+Mary+Anne%3BLaycock%2C+Maurice%3BRouse%2C+Debbie%3BMullen%2C+John&rft.aulast=DeGrasse&rft.aufirst=Stacey&rft.date=2014-05-01&rft.volume=103&rft.issue=&rft.spage=288&rft.isbn=&rft.btitle=&rft.title=Deep+Sea+Research+%28Part+II%2C+Topical+Studies+in+Oceanography%29&rft.issn=09670645&rft_id=info:doi/10.1016%2Fj.dsr2.2013.01.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 14 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Screening; Fishery management; Toxicants; ELISA; Commerce; Seafood; Paralytic shellfish poisoning; Harvesting; Public health; Fishing; Fisheries; Intoxication; Poisoning; Toxins; Risk management; Sanitation; Oceans; Shellfish; Deep sea; Drugs; Innovations; ANW, Atlantic, Georges Bank; Marine DO - http://dx.doi.org/10.1016/j.dsr2.2013.01.036 ER - TY - JOUR T1 - Paralytic shellfish toxins in clinical matrices: Extension of AOAC official method 2005.06 to human urine and serum and application to a 2007 case study in Maine AN - 1647000253; 21255458 AB - Paralytic shellfish poisoning (PSP), a potentially fatal foodborne illness, is often diagnosed anecdotally based on symptoms and dietary history. The neurotoxins responsible for PSP, collectively referred to as the saxitoxins or paralytic shellfish toxins (PSTs), are natural toxins, produced by certain dinoflagellates, that may accumulate in seafood, particularly filter-feeding bivalves. Illnesses are rare because of effective monitoring programs, yet occasional poisonings occur. Rarely are contaminated food and human clinical samples (e.g., urine and serum) available for testing. There are currently few methods, none of which are validated, for determining PSTs in clinical matrices. This study evaluated AOAC (Association of Analytical Communities) Official Method of Analysis (OMA) 2005.06 . [AOAC Official Method 2005.06 Paralytic Shellfish Poisoning Toxins in Shellfish: Prechormatographic Oxidation and Liquid Chromatography with Fluorescence Detection. In Official Methods of Analysis of AOAC International http://www.eoma.aoac.org], validated only for shellfish extracts, for its extension to human urine and serum samples. Initial assessment of control urine and serum matrices resulted in a sample cleanup modification when working with urine to remove hippuric acid, a natural urinary compound of environmental/dietary origin, which co-eluted with saxitoxin. Commercially available urine and serum matrices were then quantitatively spiked with PSTs that were available as certified reference materials (STX, dcSTX, B1, GTX2/3, C1/2, NEO, and GTX1/4) to assess method performance characteristics. The method was subsequently applied successfully to a PSP case study that occurred in July 2007 in Maine. Not only were PSTs identified in the patient urine and serum samples, the measured time series also led to the first report of human PST-specific urinary elimination rates. The LC-FD data generated from this case study compared remarkably well to results obtained using AOAC OMA 2011.27 [AOAC Official Method 2011.27 Paralytic Shellfish Toxins (PSTs) in Shellfish, Receptor Binding Assay. In Official Methods of Analysis of AOAC International http://www.eoma.aoac.org], further demonstrating successful extension of the LC-FD method to these clinical matrices. Moreover, data generated from this poisoning event reiterated that urine is a preferable clinical matrix, compared to serum, for diagnostic purposes due to higher accumulation and longer residence times in urine. JF - Deep Sea Research (Part II, Topical Studies in Oceanography) AU - DeGrasse, Stacey AU - Rivera, Victor AU - Roach, John AU - White, Kevin AU - Callahan, John AU - Couture, Darcie AU - Simone, Karen AU - Peredy, Tamas AU - Poli, Mark AD - US FDA, Center for Food Safety and Applied Nutrition, Division of Analytical Chemistry, Spectroscopy and Mass Spectrometry Branch, 5100 Paint Branch Parkway, College Park, MD 20740, United States Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 368 EP - 375 PB - Elsevier B.V., P.O. Box 800 Kidlington Oxford OX5 1DX United Kingdom VL - 103 SN - 0967-0645, 0967-0645 KW - Pollution Abstracts; ASFA 1: Biological Sciences & Living Resources; Oceanic Abstracts KW - LC-FD KW - Paralytic shellfish poisoning KW - Saxitoxin KW - Serum KW - Urine KW - Pollution monitoring KW - Symptoms KW - Toxicants KW - Residence time KW - Chromatographic techniques KW - Time series analysis KW - Case studies KW - Dinoflagellates KW - Deep sea KW - Seafood KW - ANW, USA, Maine KW - Diets KW - Marine KW - Fluorescence KW - Poisoning KW - Toxins KW - Bioaccumulation KW - Liquid chromatography KW - Shellfish KW - O 4020:Pollution - Organisms/Ecology/Toxicology KW - P 1000:MARINE POLLUTION KW - Q1 08425:Nutrition and feeding habits UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1647000253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Deep+Sea+Research+%28Part+II%2C+Topical+Studies+in+Oceanography%29&rft.atitle=Paralytic+shellfish+toxins+in+clinical+matrices%3A+Extension+of+AOAC+official+method+2005.06+to+human+urine+and+serum+and+application+to+a+2007+case+study+in+Maine&rft.au=DeGrasse%2C+Stacey%3BRivera%2C+Victor%3BRoach%2C+John%3BWhite%2C+Kevin%3BCallahan%2C+John%3BCouture%2C+Darcie%3BSimone%2C+Karen%3BPeredy%2C+Tamas%3BPoli%2C+Mark&rft.aulast=DeGrasse&rft.aufirst=Stacey&rft.date=2014-05-01&rft.volume=103&rft.issue=&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Deep+Sea+Research+%28Part+II%2C+Topical+Studies+in+Oceanography%29&rft.issn=09670645&rft_id=info:doi/10.1016%2Fj.dsr2.2012.08.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-01-01 N1 - Number of references - 19 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Symptoms; Pollution monitoring; Toxicants; Chromatographic techniques; Residence time; Serum; Urine; Seafood; Paralytic shellfish poisoning; Diets; Fluorescence; Poisoning; Time series analysis; Toxins; Case studies; Bioaccumulation; Liquid chromatography; Dinoflagellates; Shellfish; Deep sea; ANW, USA, Maine; Marine DO - http://dx.doi.org/10.1016/j.dsr2.2012.08.001 ER - TY - JOUR T1 - Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model AN - 1639474516; 21120910 AB - The current study tests the hypothesis that multi-walled carbon nanotubes (MWCNT) with different surface chemistries exhibit different bioactivity profiles in vivo. In addition, the study examined the potential contribution of the NLRP3 inflammasome in MWCNT-induced lung pathology. Unmodified (BMWCNT) and MWCNT that were surface functionalised with -COOH (FMWCNT), were instilled into C57BL/6 mice. The mice were then examined for biomarkers of inflammation and injury, as well as examined histologically for development of pulmonary disease as a function of dose and time. Biomarkers for pulmonary inflammation included cytokines, mediators and the presence of inflammatory cells (IL-1 beta , IL-18, IL-33, cathepsin B and neutrophils) and markers of injury (albumin and lactate dehydrogenase). The results show that surface modification by the addition of the - COOH group to the MWCNT, significantly reduced the bioactivity and pathogenicity. The results of this study also suggest that in vivo pathogenicity of the BMWCNT and FMWCNT correlates with activation of the NLRP3 inflammasome in the lung. JF - Nanotoxicology AU - Sager, Tina M AU - Wolfarth, Michael W AU - Andrew, Michael AU - Hubbs, Ann AU - Friend, Sherri AU - Chen, Teh-hsun AU - Porter, Dale W AU - Wu, Nianqiang AU - Yang, Feng AU - Hamilton, Raymond F AU - Holian, Andrij AD - Department Biomedical and Pharmaceutical Sciences, University of Montana, Center for Environmental Health Sciences, Missoula, MT 59812, USA; National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, WV 26505, USA; National Institute for Occupational Safety and Health, 1095 Willowdale Road, M/S 2015, Morgantown, WV 26505, USA, sst2@cdc.gov Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 317 EP - 327 PB - Informa Healthcare, 52 Vanderbilt Ave. New York New York 10017 USA VL - 8 IS - 3 SN - 1743-5390, 1743-5390 KW - Toxicology Abstracts KW - multi-walled carbon nanotube KW - surface modification KW - inflammasome activation KW - fibrosis KW - pulmonary toxicity KW - Injuries KW - Cathepsin B KW - Interleukin 1 KW - Leukocytes (neutrophilic) KW - Lung diseases KW - Animal models KW - biomarkers KW - L-Lactate dehydrogenase KW - Inflammation KW - Carbon KW - Pathogenicity KW - Interleukin 18 KW - Albumin KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639474516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nanotoxicology&rft.atitle=Effect+of+multi-walled+carbon+nanotube+surface+modification+on+bioactivity+in+the+C57BL%2F6+mouse+model&rft.au=Sager%2C+Tina+M%3BWolfarth%2C+Michael+W%3BAndrew%2C+Michael%3BHubbs%2C+Ann%3BFriend%2C+Sherri%3BChen%2C+Teh-hsun%3BPorter%2C+Dale+W%3BWu%2C+Nianqiang%3BYang%2C+Feng%3BHamilton%2C+Raymond+F%3BHolian%2C+Andrij&rft.aulast=Sager&rft.aufirst=Tina&rft.date=2014-05-01&rft.volume=8&rft.issue=3&rft.spage=317&rft.isbn=&rft.btitle=&rft.title=Nanotoxicology&rft.issn=17435390&rft_id=info:doi/10.3109%2F17435390.2013.779757 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-12-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Injuries; Interleukin 1; Cathepsin B; Animal models; Lung diseases; Leukocytes (neutrophilic); biomarkers; Inflammation; L-Lactate dehydrogenase; Carbon; Pathogenicity; Albumin; Interleukin 18 DO - http://dx.doi.org/10.3109/17435390.2013.779757 ER - TY - JOUR T1 - Protective effect of acetyl-l-carnitine on propofol-induced toxicity in embryonic neural stem cells AN - 1627976197; 20949030 AB - Propofol is a widely used general anesthetic. A growing body of data suggests that perinatal exposure to general anesthetics can result in long-term deleterious effects on brain function. In the developing brain there is evidence that general anesthetics can cause cell death, synaptic remodeling, and altered brain cell morphology. Acetyl-l-carnitine (l-Ca), an anti-oxidant dietary supplement, has been reported to prevent neuronal damage from a variety of causes. To evaluate the ability of l-Ca to protect against propofol-induced neuronal toxicity, neural stem cells were isolated from gestational day 14 rat fetuses and on the eighth day in culture were exposed for 24h to propofol at 10, 50, 100, 300 and 600 mu M, with or without l-Ca (10 mu M). Markers of cellular proliferation, mitochondrial health, cell death/damage and oxidative damage were monitored to determine: (1) the effects of propofol on neural stem cell proliferation; (2) the nature of propofol-induced neurotoxicity; (3) the degree of protection afforded by l-Ca; and (4) to provide information regarding possible mechanisms underlying protection. After propofol exposure at a clinically relevant concentration (50 mu M), the number of dividing cells was significantly decreased, oxidative DNA damage was increased and a significant dose-dependent reduction in mitochondrial function/health was observed. No significant effect on lactase dehydrogenase (LDH) release was observed at propofol concentrations up to 100 mu M. The oxidative damage at 50 mu M propofol was blocked by l-Ca. Thus, clinically relevant concentrations of propofol induce dose-dependent adverse effects on rat embryonic neural stem cells by slowing or stopping cell division/proliferation and causing cellular damage. Elevated levels of 8-oxoguanine suggest enhanced oxidative damage [reactive oxygen species (ROS) generation] and l-Ca effectively blocks at least some of the toxicity of propofol, presumably by scavenging oxidative species and/or reducing their production. JF - Neurotoxicology AU - Liu, Fang AU - Rainosek, Shuo W AU - Sadovova, Natalya AU - Fogle, Charles M AU - Patterson, Tucker A AU - Hanig, Joseph P AU - Paule, Merle G AU - Slikker, William Jr AU - Wang, Cheng AD - Division of Neurotoxicology, National Center for Toxicological Research/Food and Drug Administration, Jefferson, AR 72079, USA Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 49 EP - 57 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 42 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - CNS central nervous system KW - GABA gamma-aminobutyric acid KW - l-Ca acetyl-l-carnitine KW - DMEM Dulbecco's modified Eagle's medium KW - ELISA enzyme-linked immunosorbent assay KW - TUNEL terminal deoxynucleotidyl transferase (TdT)-mediated deoxy-uridine triphosphate (dUTP) nick end labeling KW - MTT 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide KW - LDH lactate dehydrogenase KW - Neural stem cells KW - Propofol KW - Apoptosis KW - Protection KW - Data processing KW - Lactase KW - Acetyl-L-carnitine KW - Brain KW - Mitochondria KW - Anesthetics KW - Cell culture KW - DNA damage KW - Stem cells KW - Cell death KW - Cell division KW - Reactive oxygen species KW - Embryo cells KW - Neurotoxicity KW - Embryos KW - Cell proliferation KW - Side effects KW - N3 11007:Neurobiology KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1627976197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Protective+effect+of+acetyl-l-carnitine+on+propofol-induced+toxicity+in+embryonic+neural+stem+cells&rft.au=Liu%2C+Fang%3BRainosek%2C+Shuo+W%3BSadovova%2C+Natalya%3BFogle%2C+Charles+M%3BPatterson%2C+Tucker+A%3BHanig%2C+Joseph+P%3BPaule%2C+Merle+G%3BSlikker%2C+William+Jr%3BWang%2C+Cheng&rft.aulast=Liu&rft.aufirst=Fang&rft.date=2014-05-01&rft.volume=42&rft.issue=&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2014.03.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-11-01 N1 - Last updated - 2014-12-11 N1 - SubjectsTermNotLitGenreText - Data processing; Lactase; Brain; Acetyl-L-carnitine; Anesthetics; Mitochondria; Cell culture; DNA damage; Cell division; Cell death; Stem cells; Embryo cells; Reactive oxygen species; Neurotoxicity; Embryos; Cell proliferation; Propofol; Neural stem cells; Side effects DO - http://dx.doi.org/10.1016/j.neuro.2014.03.011 ER - TY - JOUR T1 - Quantitative dose-response analysis of ethyl methanesulfonate genotoxicity in adult gpt-delta transgenic mice AN - 1551624981; 20079604 AB - The assumption that mutagens have linear dose-responses recently has been challenged. In particular, ethyl methanesulfonate (EMS), a DNA-reactive mutagen and carcinogen, exhibited sublinear or thresholded dose-responses for LacZ mutation in transgenic Muta(TM)Mouse and for micronucleus (MN) frequency in CD1 mice (Gocke E and Mueller L [2009]: Mutat Res 678:101-107). In order to explore variables in establishing genotoxicity dose-responses, we characterized the genotoxicity of EMS using gene mutation assays anticipated to have lower spontaneous mutant frequencies (MFs) than Muta(TM)Mouse. Male gpt-delta transgenic mice were treated daily for 28 days with 5 to 100 mg/kg EMS, and measurements were made on: (i) gpt MFs in liver, lung, bone marrow, kidney, small intestine, and spleen; and (ii) Pig-a MFs in peripheral blood reticulocytes (RETs) and total red blood cells. MN induction also was measured in peripheral blood RETs. These data were used to calculate Points of Departure (PoDs) for the dose responses, i.e., no-observed-genotoxic-effect-levels (NOGELs), lower confidence limits of threshold effect levels (Td-LCIs), and lower confidence limits of 10% benchmark response rates (BMDL sub(10)s). Similar PoDs were calculated from the published EMS dose-responses for LacZ mutation and CD1 MN induction. Vehicle control gpt and Pig-a MFs were 13-40-fold lower than published vehicle control LacZ MFs. In general, the EMS genotoxicity dose-responses in gpt-delta mice had lower PoDs than those calculated from the Muta(TM)Mouse and CD1 mouse data. Our results indicate that the magnitude and possibly the shape of mutagenicity dose responses differ between in vivo models, with lower PoDs generally detected by gene mutation assays with lower backgrounds. Environ. Mol. Mutagen. 55:385-399, 2014. copyright 2014 Wiley Periodicals, Inc. JF - Environmental and Molecular Mutagenesis AU - Cao, Xuefei AU - Mittelstaedt, Roberta A AU - Pearce, Mason G AU - Allen, Bruce C AU - Soeteman-Hernandez, Lya G AU - Johnson, George E AU - Bigger, CAnita H AU - Heflich, Robert H AD - U.S. Food and Drug Administration, National Center for Toxicological Research, Jefferson, Arkansas. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 385 EP - 399 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 55 IS - 5 SN - 0893-6692, 0893-6692 KW - Toxicology Abstracts; Genetics Abstracts KW - Mutagens KW - Threshold limits KW - Erythrocytes KW - Bone marrow KW - Small intestine KW - Ethyl methanesulfonate KW - Carcinogens KW - Mutants KW - Mutagenesis KW - Dose-response effects KW - Manganese KW - Mutagenicity KW - Data processing KW - Point mutation KW - Genotoxicity KW - Spleen KW - Mice KW - Peripheral blood KW - Transgenic mice KW - Lung KW - Kidney KW - Liver KW - Benchmarks KW - Mutation KW - Reticulocytes KW - X 24360:Metals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551624981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+and+Molecular+Mutagenesis&rft.atitle=Quantitative+dose-response+analysis+of+ethyl+methanesulfonate+genotoxicity+in+adult+gpt-delta+transgenic+mice&rft.au=Cao%2C+Xuefei%3BMittelstaedt%2C+Roberta+A%3BPearce%2C+Mason+G%3BAllen%2C+Bruce+C%3BSoeteman-Hernandez%2C+Lya+G%3BJohnson%2C+George+E%3BBigger%2C+CAnita+H%3BHeflich%2C+Robert+H&rft.aulast=Cao&rft.aufirst=Xuefei&rft.date=2014-05-01&rft.volume=55&rft.issue=5&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Environmental+and+Molecular+Mutagenesis&rft.issn=08936692&rft_id=info:doi/10.1002%2Fem.21854 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-08-01 N1 - Last updated - 2015-10-28 N1 - SubjectsTermNotLitGenreText - Mutagens; Data processing; Genotoxicity; Point mutation; Erythrocytes; Threshold limits; Bone marrow; Spleen; Peripheral blood; Ethyl methanesulfonate; Small intestine; Carcinogens; Transgenic mice; Mutagenesis; Lung; Liver; Kidney; Reticulocytes; Manganese; Mutagenicity; Mice; Mutants; Dose-response effects; Benchmarks; Mutation DO - http://dx.doi.org/10.1002/em.21854 ER - TY - JOUR T1 - Prevalence of Obesity by Occupation Among US Workers The National Health Interview Survey 2004-2011 AN - 1547851146; 20285692 AB - Objective: To estimate the prevalence of obesity and the change of prevalence of obesity between 2004-2007 and 2008-20011 by occupation among US workers in the National Health Interview Survey. Methods: Self-reported weight and height were collected and used to assess obesity (body mass index > or = 30 kg/m super(2)). Gender-, race/ethnicity-, and occupation-specific prevalence of obesity were calculated. Results: Prevalence of obesity steadily increased from 2004 through 2008 across gender and race/ethnicity but leveled off from 2008 through 2011. Non-Hispanic black female workers in health care support (49.2%) and transportation/material moving (46.6%) had the highest prevalence of obesity. Prevalence of obesity in relatively low-obesity (white-collar) occupations significantly increased between 2004-2007 and 2008-2011, whereas it did not change significantly in high-obesity (blue-collar) occupations. Conclusions: Workers in all occupational categories are appropriate targets for health promotion and intervention programs to reduce obesity. JF - Journal of Occupational and Environmental Medicine AU - Gu, Ja K AU - Charles, Luenda E AU - Bang, Ki Moon AU - Ma, Claudia C AU - Andrew, Michael E AU - Violanti, John M AU - Burchfiel, Cecil M AD - Biostatistics and Epidemiology Branch, Health Effects Laboratory Division; National Institute for Occupational Safety and Health, HELD/BEB, Mailstop L-4050, 1095 Willowdale Rd, Morgantown, WV 26505, jgu@cdc.gov PY - 2014 SP - 516 EP - 528 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 56 IS - 5 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Obesity KW - Transportation KW - Health care KW - Body mass KW - Gender KW - Intervention KW - Ethnic groups KW - Health promotion KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1547851146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Prevalence+of+Obesity+by+Occupation+Among+US+Workers+The+National+Health+Interview+Survey+2004-2011&rft.au=Gu%2C+Ja+K%3BCharles%2C+Luenda+E%3BBang%2C+Ki+Moon%3BMa%2C+Claudia+C%3BAndrew%2C+Michael+E%3BViolanti%2C+John+M%3BBurchfiel%2C+Cecil+M&rft.aulast=Gu&rft.aufirst=Ja&rft.date=2014-05-01&rft.volume=56&rft.issue=5&rft.spage=516&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000133 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Obesity; Transportation; Health care; Body mass; Gender; Intervention; Ethnic groups; Health promotion DO - http://dx.doi.org/10.1097/JOM.0000000000000133 ER - TY - JOUR T1 - Stereomicroscopic Imaging Technique for the Quantification of Cold Flow in Drug-in-Adhesive Type of Transdermal Drug Delivery Systems AN - 1544000633; 19626248 AB - Cold flow is a phenomenon occurring in drug-in-adhesive type of transdermal drug delivery systems (DIA-TDDS) because of the migration of DIA coat beyond the edge. Excessive cold flow can affect their therapeutic effectiveness, make removal of DIA-TDDS difficult from the pouch, and potentially decrease available dose if any drug remains adhered to pouch. There are no compendial or noncompendial methods available for quantification of this critical quality attribute. The objective was to develop a method for quantification of cold flow using stereomicroscopic imaging technique. Cold flow was induced by applying 1 kg force on punched-out samples of marketed estradiol DIA-TDDS (model product) stored at 25 degree C, 32 degree C, and 40 degree C/60% relative humidity (RH) for 1, 2, or 3 days. At the end of testing period, dimensional change in the area of DIA-TDDS samples was measured using image analysis software, and expressed as percent of cold flow. The percent of cold flow significantly decreased (p < 0.001) with increase in size of punched-out DIA-TDDS samples and increased (p < 0.001) with increase in cold flow induction temperature and time. This first ever report suggests that dimensional change in the area of punched-out samples stored at 32 degree C/60%RH for 2 days applied with 1 kg force could be used for quantification of cold flow in DIA-TDDS. copyright 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1433-1442, 2014 JF - Journal of Pharmaceutical Sciences AU - Krishnaiah, Yellela SR AU - Katragadda, Usha AU - Khan, Mansoor A AD - Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, 20993. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 1433 EP - 1442 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 103 IS - 5 SN - 0022-3549, 0022-3549 KW - Biotechnology and Bioengineering Abstracts KW - Relative humidity KW - Temperature effects KW - Drug delivery KW - Computer programs KW - software KW - Stored products KW - Image processing KW - imaging KW - Migration KW - Estradiol KW - Models KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1544000633?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pharmaceutical+Sciences&rft.atitle=Stereomicroscopic+Imaging+Technique+for+the+Quantification+of+Cold+Flow+in+Drug-in-Adhesive+Type+of+Transdermal+Drug+Delivery+Systems&rft.au=Krishnaiah%2C+Yellela+SR%3BKatragadda%2C+Usha%3BKhan%2C+Mansoor+A&rft.aulast=Krishnaiah&rft.aufirst=Yellela&rft.date=2014-05-01&rft.volume=103&rft.issue=5&rft.spage=1433&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pharmaceutical+Sciences&rft.issn=00223549&rft_id=info:doi/10.1002%2Fjps.23915 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2014-07-10 N1 - SubjectsTermNotLitGenreText - Temperature effects; Relative humidity; Computer programs; Drug delivery; software; Stored products; Image processing; Migration; imaging; Estradiol; Models DO - http://dx.doi.org/10.1002/jps.23915 ER - TY - JOUR T1 - Genetic Diversity and Evolution of Salmonella enterica Serovar Enteritidis Strains with Different Phage Types AN - 1534846822; 19798186 AB - Phage typing has been used for the epidemiological surveillance of Salmonella enterica serovar Enteritidis for over 2 decades. However, knowledge of the genetic and evolutionary relationships between phage types is very limited, making differences difficult to interpret. Here, single nucleotide polymorphisms (SNPs) identified from whole-genome comparisons were used to determine the relationships between some S. Enteritidis phage types (PTs) commonly associated with food-borne outbreaks in the United States. Emphasis was placed on the predominant phage types PT8, PT13a, and PT13 in North America. With >89,400 bp surveyed across 98 S. Enteritidis isolates representing 14 distinct phage types, 55 informative SNPs were discovered within 23 chromosomally anchored loci. To maximize the discriminatory and evolutionary partitioning of these highly homogeneous strains, sequences comprising informative SNPs were concatenated into a single combined data matrix and subjected to phylogenetic analysis. The resultant phylogeny allocated most S. Enteritidis isolates into two distinct clades (clades I and II) and four subclades. Synapomorphic (shared and derived) sets of SNPs capable of distinguishing individual clades/subclades were identified. However, individual phage types appeared to be evolutionarily disjunct when mapped to this phylogeny, suggesting that phage typing may not be valid for making phylogenetic inferences. Furthermore, the set of SNPs identified here represents useful genetic markers for strain differentiation of more clonal S. Enteritidis strains and provides core genotypic markers for future development of a SNP typing scheme with S. Enteritidis. JF - Journal of Clinical Microbiology AU - Zheng, Jie AU - Pettengill, James AU - Strain, Errol AU - Allard, Marc W AU - Ahmed, Rafiq AU - Zhao, Shaohua AU - Brown, Eric W AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, Maryland, USA, jie.zheng@fda.hhs.gov. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 1490 EP - 1500 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 52 IS - 5 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; ASFA 1: Biological Sciences & Living Resources KW - Phages KW - Phylogeny KW - Data processing KW - Food KW - Anadromous species KW - Nucleotide sequence KW - Surveillance and enforcement KW - Genetic diversity KW - Strains KW - Nucleotides KW - Differentiation KW - USA KW - Phage typing KW - Single-nucleotide polymorphism KW - Salmonella enterica KW - Genetic markers KW - Microbiology KW - Evolution KW - Phylogenetics KW - J 02310:Genetics & Taxonomy KW - Q1 08205:Genetics and evolution KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534846822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Genetic+Diversity+and+Evolution+of+Salmonella+enterica+Serovar+Enteritidis+Strains+with+Different+Phage+Types&rft.au=Zheng%2C+Jie%3BPettengill%2C+James%3BStrain%2C+Errol%3BAllard%2C+Marc+W%3BAhmed%2C+Rafiq%3BZhao%2C+Shaohua%3BBrown%2C+Eric+W&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2014-05-01&rft.volume=52&rft.issue=5&rft.spage=1490&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/10.1128%2FJCM.00051-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Number of references - 67 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Phylogeny; Nucleotide sequence; Anadromous species; Microbiology; Surveillance and enforcement; Strains; Nucleotides; Phylogenetics; Evolution; Phages; Differentiation; Data processing; Phage typing; Single-nucleotide polymorphism; Food; Genetic markers; Genetic diversity; Salmonella enterica; USA DO - http://dx.doi.org/10.1128/JCM.00051-14 ER - TY - JOUR T1 - DNA double-strand break repair and induction of apoptosis in ex vivo irradiated blood lymphocytes in relation to late normal tissue reactions following breast radiotherapy AN - 1534843500; 19763675 AB - This study aimed to test whether induction of apoptosis following ex vivo X-irradiation of unstimulated blood lymphocytes correlated with clinical radiosensitivity and DNA double-strand break (DSB) repair in breast radiotherapy patients and healthy volunteers. Using small molecule inhibitors, the relationship between DSB repair and radiation-induced apoptosis was examined. Sixteen breast cancer patients with minimal (controls, n = 8) or extremely marked late radiation-induced change (cases, n = 8) and eight healthy volunteers were selected. DSBs were quantified by gamma H2AX/53BP1 immunofluorescence, and apoptosis was measured using a fluorogenic inhibitor of caspases assay. Mean gamma H2AX/53BP1 focus levels 24 h after exposure to 4 Gy were higher in cases (12.7 foci per cell) than in controls (10.3 foci per cell, p = 0.002). In contrast, the mean apoptotic fraction 48 h after 8 Gy was comparable, 37.2 % in cases and 34.7 % in controls (p = 0.442). Residual focus and apoptosis levels were not correlated within individuals (Spearman's R = -0.0059, p = 0.785). However, cells treated with DNA-PK inhibitor Nu7441 had higher focus and apoptosis levels 48 h after 1 Gy compared to mock-treated cells, suggesting that apoptosis induction following irradiation is modulated by DSB repair. This effect required functional ATM since cells treated simultaneously with Nu7441 and the ATM inhibitor Ku55933 were resistant to apoptosis despite high levels of residual foci. One clinical case displayed an impaired DNA-PK-dependent end-joining cellular phenotype. In summary, clinical radiosensitivity may be associated with impaired DSB repair in some patients. Although pharmaceutical inhibition of ATM and DNA-PK affected apoptosis induction and DSB repair, no association was observed between apoptosis and residual focus levels in patients and volunteers. JF - Radiation and Environmental Biophysics AU - Chua, Melvin Lee Kiang AU - Horn, Simon AU - Somaiah, Navita AU - Davies, Sue AU - Gothard, Lone AU - A'Hern, Roger AU - Yarnold, John AU - Rothkamm, Kai AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, OX11 0RQ, UK, kai.rothkamm@phe.gov.uk Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 355 EP - 364 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 53 IS - 2 SN - 0301-634X, 0301-634X KW - Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Tissues KW - X radiation KW - Apoptosis KW - Radiotherapy KW - Immunofluorescence KW - Lymphocytes KW - Double-strand break repair KW - DNA repair KW - DNA-dependent protein kinase KW - Blood KW - DNA damage KW - Radiation KW - Irradiation KW - DNA KW - Breast cancer KW - Radiosensitivity KW - Pharmaceuticals KW - Caspase KW - H 8000:Radiation Safety/Electrical Safety KW - F 06915:Cancer Immunology KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534843500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+and+Environmental+Biophysics&rft.atitle=DNA+double-strand+break+repair+and+induction+of+apoptosis+in+ex+vivo+irradiated+blood+lymphocytes+in+relation+to+late+normal+tissue+reactions+following+breast+radiotherapy&rft.au=Chua%2C+Melvin+Lee+Kiang%3BHorn%2C+Simon%3BSomaiah%2C+Navita%3BDavies%2C+Sue%3BGothard%2C+Lone%3BA%27Hern%2C+Roger%3BYarnold%2C+John%3BRothkamm%2C+Kai&rft.aulast=Chua&rft.aufirst=Melvin+Lee&rft.date=2014-05-01&rft.volume=53&rft.issue=2&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Radiation+and+Environmental+Biophysics&rft.issn=0301634X&rft_id=info:doi/10.1007%2Fs00411-014-0531-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Number of references - 37 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - X radiation; Apoptosis; Radiotherapy; Lymphocytes; Immunofluorescence; DNA repair; Double-strand break repair; DNA-dependent protein kinase; DNA damage; Blood; Radiation; Pharmaceuticals; Radiosensitivity; Breast cancer; Caspase; Tissues; Irradiation; DNA DO - http://dx.doi.org/10.1007/s00411-014-0531-z ER - TY - JOUR T1 - DILI and drug development: a regulatory perspective. AN - 1531953237; 24879985 AB - The assessment of risk for serious, life-threatening drug-induced liver injury (DILI) associated with a suspect drug, biological agent, or herbal product depends on an iterative analysis of pre- and postmarket datastreams. Because serious cases of idiosyncratic DILI are typically rare, regulatory scientists seek strategies that accurately predict from clinical trial data which study drugs will be likely to cause these events in a large postmarket treatment population, e.g., through the identification of cases that are consistent with Hy's law. This objective is only achievable if rigorous standards in study subject monitoring, data collection and analysis of liver injury cases for causality are followed. In the future, the development of more effective predictive and analytic tools in preclinical and clinical testing will provide a framework to reliably identify new agents that have hepatotoxic profiles as well as those individuals who are susceptible to develop serious DILI. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA. JF - Seminars in liver disease AU - Avigan, Mark I AD - Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 215 EP - 226 VL - 34 IS - 2 KW - Biomarkers KW - 0 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - United States KW - Aspartate Aminotransferases -- blood KW - Sentinel Surveillance KW - Alanine Transaminase -- blood KW - United States Food and Drug Administration KW - Humans KW - Bilirubin -- blood KW - Biomarkers -- blood KW - Risk Assessment -- legislation & jurisprudence KW - Chemical and Drug Induced Liver Injury -- blood KW - Chemical and Drug Induced Liver Injury -- etiology KW - Chemical and Drug Induced Liver Injury -- diagnosis KW - Product Surveillance, Postmarketing KW - Clinical Trials as Topic KW - Legislation, Drug UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1531953237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+liver+disease&rft.atitle=DILI+and+drug+development%3A+a+regulatory+perspective.&rft.au=Avigan%2C+Mark+I&rft.aulast=Avigan&rft.aufirst=Mark&rft.date=2014-05-01&rft.volume=34&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Seminars+in+liver+disease&rft.issn=1098-8971&rft_id=info:doi/10.1055%2Fs-0034-1375961 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-23 N1 - Date created - 2014-06-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1055/s-0034-1375961 ER - TY - JOUR T1 - Development and Use of a Serum Bactericidal Assay Using Pooled Human Complement To Assess Responses to a Meningococcal Group A Conjugate Vaccine in African Toddlers AN - 1529934061; 19846344 AB - A meningococcal group A polysaccharide (PS) conjugate vaccine (PsA-TT) has been developed for African countries affected by epidemic meningitis caused by Neisseria meningitidis. Complement-mediated serum bactericidal antibody (SBA) assays are used to assess protective immune responses to meningococcal vaccination. Human complement (hC') was used in early studies demonstrating antibody-mediated protection against disease, but it is difficult to obtain and standardize. We developed and evaluated a method for sourcing hC' and then used the SBA assay with hC' (hSBA) to measure bactericidal responses to PsA-TT vaccination in 12- to 23-month-old African children. Sera with active complement from 100 unvaccinated blood donors were tested for intrinsic bactericidal activity, SBA titer using rabbit complement (rSBA), and anti-group A PS antibody concentration. Performance criteria and pooling strategies were examined and then verified by comparisons of three independently prepared hC' lots in two laboratories. hSBA titers of clinical trial sera were then determined using this complement sourcing method. Two different functional antibody tests were necessary for screening hC'. hSBA titers determined using three independent lots of pooled hC' were within expected assay variation among lots and between laboratories. In African toddlers, PsA-TT elicited higher hSBA titers than meningococcal polysaccharide or Hib vaccines. PsA-TT immunization or PS challenge of PsA-TT-primed subjects resulted in vigorous hSBA memory responses, and titers persisted in boosted groups for over a year. Quantifying SBA using pooled hC' is feasible and showed that PsA-TT was highly immunogenic in African toddlers. JF - Clinical and Vaccine Immunology AU - Bash, Margaret C AU - Lynn, Freyja AU - Mocca, Brian AU - Borrow, Ray AU - Findlow, Helen AU - Hassan-King, Musa AU - Preziosi, Marie-Pierre AU - Idoko, Olubukola AU - Sow, Samba AU - Kulkarni, Prasad AD - Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA, margaret.bash@fda.hhs.gov. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 755 EP - 761 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 21 IS - 5 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Bacteria KW - Blood donors KW - Epidemics KW - Complement KW - Immunological memory KW - Neisseria meningitidis KW - Children KW - Polysaccharides KW - Clinical trials KW - Meningitis KW - Antibodies KW - Immunogenicity KW - Immune response KW - Vaccines KW - Bactericidal activity KW - F 06905:Vaccines KW - A 01300:Methods KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1529934061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Development+and+Use+of+a+Serum+Bactericidal+Assay+Using+Pooled+Human+Complement+To+Assess+Responses+to+a+Meningococcal+Group+A+Conjugate+Vaccine+in+African+Toddlers&rft.au=Bash%2C+Margaret+C%3BLynn%2C+Freyja%3BMocca%2C+Brian%3BBorrow%2C+Ray%3BFindlow%2C+Helen%3BHassan-King%2C+Musa%3BPreziosi%2C+Marie-Pierre%3BIdoko%2C+Olubukola%3BSow%2C+Samba%3BKulkarni%2C+Prasad&rft.aulast=Bash&rft.aufirst=Margaret&rft.date=2014-05-01&rft.volume=21&rft.issue=5&rft.spage=755&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00812-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Number of references - 23 N1 - Last updated - 2015-11-25 N1 - SubjectsTermNotLitGenreText - Blood donors; Epidemics; Complement; Immunological memory; Polysaccharides; Children; Clinical trials; Meningitis; Antibodies; Immunogenicity; Vaccines; Immune response; Bactericidal activity; Bacteria; Neisseria meningitidis DO - http://dx.doi.org/10.1128/CVI.00812-13 ER - TY - JOUR T1 - Role of Antibodies in Protection Elicited by Active Vaccination with Genetically Inactivated Alpha Hemolysin in a Mouse Model of Staphylococcus aureus Skin and Soft Tissue Infections AN - 1529934044; 19846330 AB - Due to the emergence of highly virulent community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections, S. aureus has become a major threat to public health. A majority of CA-MRSA skin and soft tissue infections in the United States are caused by S. aureus USA300 strains that are known to produce high levels of alpha hemolysin (Hla). Therefore, vaccines that contain inactivated forms of this toxin are currently being developed. In this study, we sought to determine the immune mechanisms of protection for this antigen using a vaccine composed of a genetically inactivated form of Hla (HlaH35L). Using a murine model of skin and soft tissue infections (SSTI), we found that BALB/c mice were protected by vaccination with HlaH35L; however, Jh mice, which are deficient in mature B lymphocytes and lack IgM and IgG in their serum, were not protected. Passive immunization with anti-HlaH35L antibodies conferred protection against bacterial colonization. Moreover, we found a positive correlation between the total antibody concentration induced by active vaccination and reduced bacterial levels. Animals that developed detectable neutralizing antibody titers after active vaccination were significantly protected from infection. These data demonstrate that antibodies to Hla represent the major mechanism of protection afforded by active vaccination with inactivated Hla in this murine model of SSTI, and in this disease model, antibody levels correlate with protection. These results provide important information for the future development and evaluation of S. aureus vaccines. JF - Clinical and Vaccine Immunology AU - Mocca, Christopher P AU - Brady, Rebecca A AU - Burns, Drusilla L Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 622 EP - 627 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 21 IS - 5 SN - 1556-679X, 1556-679X KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Histocompatibility antigen HLA KW - Data processing KW - Skin KW - Lymphocytes B KW - Drug resistance KW - Animal models KW - Infection KW - Toxins KW - Public health KW - Colonization KW - Immunoglobulin G KW - Immunization (passive) KW - Vaccines KW - Staphylococcus aureus KW - Hemolysins KW - Soft tissues KW - Immunoglobulin M KW - F 06905:Vaccines KW - J 02350:Immunology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1529934044?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Role+of+Antibodies+in+Protection+Elicited+by+Active+Vaccination+with+Genetically+Inactivated+Alpha+Hemolysin+in+a+Mouse+Model+of+Staphylococcus+aureus+Skin+and+Soft+Tissue+Infections&rft.au=Mocca%2C+Christopher+P%3BBrady%2C+Rebecca+A%3BBurns%2C+Drusilla+L&rft.aulast=Mocca&rft.aufirst=Christopher&rft.date=2014-05-01&rft.volume=21&rft.issue=5&rft.spage=622&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00051-14 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Number of references - 29 N1 - Last updated - 2015-06-26 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Skin; Data processing; Lymphocytes B; Drug resistance; Animal models; Infection; Toxins; Public health; Colonization; Immunoglobulin G; Immunization (passive); Vaccines; Soft tissues; Hemolysins; Immunoglobulin M; Staphylococcus aureus DO - http://dx.doi.org/10.1128/CVI.00051-14 ER - TY - JOUR T1 - Cell-recycle continuous fermentation of Enterococcus faecalis RKY1 for economical production of lactic acid by reduction of yeast extract supplementation. AN - 1527328551; 24561722 AB - Both lactic acid productivity and cell growth were linearly correlated with yeast extract supplementation in batch fermentation. During conventional continuous operation, although fresh feed was introduced into the bioreactor with a significantly low dilution rate (0.04 h(-1)), the amount of yeast extract employed was not enough to maintain the growth of microorganism. However, when the fresh feed contained 100 g/l glucose and 2 g/l yeast extract during cell-recycle continuous operation at a dilution rate of 0.04 h(-1), more than 90 g/l lactic acid was continuously produced, with the average productivity of 3.72 g/l·h. In this experiment, 82 g of yeast extract (77% of reduction yield) could be reduced for the production of 1 kg of lactic acid compared with batch fermentation of a similar volumetric productivity. JF - Journal of microbiology and biotechnology AU - Lee, Ryun-Kyung AU - Ryu, Hwa-Won AU - Oh, Hurok AU - Kim, Mina AU - Wee, Young-Jung AD - Department of Food Science and Technology, Yeungnam University, Gyeongsan 712-749, Republic of Korea, Hazardous Substances Analysis Division, Daegu Regional Food and Drug Administration, Daegu 704-940, Republic of Korea. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 661 EP - 666 VL - 24 IS - 5 KW - Culture Media KW - 0 KW - Lactic Acid KW - 33X04XA5AT KW - Index Medicus KW - Bioreactors KW - Cell Cycle KW - Culture Media -- chemistry KW - Batch Cell Culture Techniques KW - Lactic Acid -- biosynthesis KW - Fermentation KW - Enterococcus faecalis -- metabolism KW - Enterococcus faecalis -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1527328551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+microbiology+and+biotechnology&rft.atitle=Cell-recycle+continuous+fermentation+of+Enterococcus+faecalis+RKY1+for+economical+production+of+lactic+acid+by+reduction+of+yeast+extract+supplementation.&rft.au=Lee%2C+Ryun-Kyung%3BRyu%2C+Hwa-Won%3BOh%2C+Hurok%3BKim%2C+Mina%3BWee%2C+Young-Jung&rft.aulast=Lee&rft.aufirst=Ryun-Kyung&rft.date=2014-05-01&rft.volume=24&rft.issue=5&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Journal+of+microbiology+and+biotechnology&rft.issn=1738-8872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-14 N1 - Date created - 2014-05-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Development and evolution of risk assessment for food allergens. AN - 1526127574; 24508585 AB - The need to assess the risk from food allergens derives directly from the need to manage effectively this food safety hazard. Work spanning the last two decades dispelled the initial thinking that food allergens were so unique that the risk they posed was not amenable to established risk assessment approaches and methodologies. Food allergens possess some unique characteristics, which make a simple safety assessment approach based on the establishment of absolute population thresholds inadequate. Dose distribution modelling of MEDs permitted the quantification of the risk of reaction at the population level and has been readily integrated with consumption and contamination data through probabilistic risk assessment approaches to generate quantitative risk predictions. This paper discusses the strengths and limitations of this approach and identifies important data gaps, which affect the outcomes of these predictions. These include consumption patterns among allergic individuals, analytical techniques and their application, severity-dose relationships, and the impact of extraneous factors which alter an individual's physiology, such as infection or exercise. Nevertheless, application of these models has provided valuable insights, leading to further refinements and generating testable hypotheses. Their application to estimate the risk posed by the concurrent consumption of two potentially contaminated foods illustrates their power. Copyright © 2014 ILSI Europe. Published by Elsevier Ltd.. All rights reserved. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Crevel, René W R AU - Baumert, Joseph L AU - Baka, Athanasia AU - Houben, Geert F AU - Knulst, André C AU - Kruizinga, Astrid G AU - Luccioli, Stefano AU - Taylor, Stephen L AU - Madsen, Charlotte B AD - Safety and Environmental Assurance Centre, Unilever, Colworth House, Sharnbrook, Bedford, UK. ; University of Nebraska, Lincoln, USA. ; International Life Sciences Institute - ILSI Europe, Brussels, Belgium. Electronic address: publications@ilsieurope.be. ; The Netherlands Organisation for Applied Scientific Research TNO, Zeist, The Netherlands. ; University Medical Centre Utrecht, Utrecht, The Netherlands. ; Center for Food Safety and Applied Nutrition, FDA, College Park, Maryland, USA. ; Technical University of Denmark, Lyngby, Denmark. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 262 EP - 276 VL - 67 KW - Allergens KW - 0 KW - Index Medicus KW - Risk assessment KW - Probabilistic modelling KW - Food allergy KW - Reference dose KW - Thresholds KW - Public health KW - Uncertainty KW - Probability KW - Food Contamination -- analysis KW - Allergens -- analysis KW - Risk Assessment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1526127574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Development+and+evolution+of+risk+assessment+for+food+allergens.&rft.au=Crevel%2C+Ren%C3%A9+W+R%3BBaumert%2C+Joseph+L%3BBaka%2C+Athanasia%3BHouben%2C+Geert+F%3BKnulst%2C+Andr%C3%A9+C%3BKruizinga%2C+Astrid+G%3BLuccioli%2C+Stefano%3BTaylor%2C+Stephen+L%3BMadsen%2C+Charlotte+B&rft.aulast=Crevel&rft.aufirst=Ren%C3%A9+W&rft.date=2014-05-01&rft.volume=67&rft.issue=&rft.spage=262&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2014.01.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-09 N1 - Date created - 2014-04-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2014.01.032 ER - TY - JOUR T1 - Translating reference doses into allergen management practice: challenges for stakeholders. AN - 1526127124; 24491260 AB - Risk assessment describes the impact of a particular hazard as a function of dose and exposure. It forms the foundation of risk management and contributes to the overall decision-making process, but is not its endpoint. This paper outlines a risk analysis framework to underpin decision-making in the area of allergen cross-contact. Specifically, it identifies challenges relevant to each component of the risk analysis: risk assessment (data gaps and output interpretation); risk management (clear and realistic objectives); and risk communication (clear articulation of risk and benefit). Translation of the outputs from risk assessment models into risk management measures must be informed by a clear understanding of the model outputs and their limitations. This will lead to feasible and achievable risk management objectives, grounded in a level of risk accepted by the different stakeholders, thereby avoiding potential unintended detrimental consequences. Clear, consistent and trustworthy communications actively involving all stakeholders underpin these objectives. The conclusions, integrating the perspectives of different stakeholders, offer a vision where clear, science-based benchmarks form the basis of allergen management and labelling, cutting through the current confusion and uncertainty. Finally, the paper recognises that the proposed framework must be adaptable to new and emerging evidence. Copyright © 2014 ILSI Europe. Published by Elsevier Ltd.. All rights reserved. JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association AU - Crevel, René W R AU - Baumert, Joseph L AU - Luccioli, Stefano AU - Baka, Athanasia AU - Hattersley, Sue AU - Hourihane, Jonathan O'B AU - Ronsmans, Stefan AU - Timmermans, Frans AU - Ward, Rachel AU - Chung, Yong-joo AD - Safety and Environmental Assurance Centre, Unilever, Colworth House, Sharnbrook, Bedford, UK. ; Food Allergy Research and Resource Program, University of Nebraska, Lincoln, USA. ; Center for Food Safety and Applied Nutrition, FDA, USA. ; International Life Sciences Institute-ILSI Europe, Brussels, Belgium. Electronic address: publications@ilsieurope.be. ; UK Food Standards Agency, London, UK. ; Department of Paediatrics, School of Medicine, University College Cork, Cork, Ireland. ; Coca-Cola Services, Brussels, Belgium. ; European Anaphylaxis Taskforce and Nederlands Anafylaxis Netwerk, Dordrecht, The Netherlands. ; R. Ward Consultancy Limited, Nottingham, UK. ; Nestlé Research Centre, Lausanne, Switzerland. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 277 EP - 287 VL - 67 KW - Allergens KW - 0 KW - Index Medicus KW - Risk assessment KW - Probabilistic modelling KW - Food allergy KW - Reference dose KW - Public health KW - Eliciting dose KW - Humans KW - Dose-Response Relationship, Immunologic KW - Allergens -- toxicity KW - Allergens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1526127124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.atitle=Translating+reference+doses+into+allergen+management+practice%3A+challenges+for+stakeholders.&rft.au=Crevel%2C+Ren%C3%A9+W+R%3BBaumert%2C+Joseph+L%3BLuccioli%2C+Stefano%3BBaka%2C+Athanasia%3BHattersley%2C+Sue%3BHourihane%2C+Jonathan+O%27B%3BRonsmans%2C+Stefan%3BTimmermans%2C+Frans%3BWard%2C+Rachel%3BChung%2C+Yong-joo&rft.aulast=Crevel&rft.aufirst=Ren%C3%A9+W&rft.date=2014-05-01&rft.volume=67&rft.issue=&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Food+and+chemical+toxicology+%3A+an+international+journal+published+for+the+British+Industrial+Biological+Research+Association&rft.issn=1873-6351&rft_id=info:doi/10.1016%2Fj.fct.2014.01.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-02-09 N1 - Date created - 2014-04-14 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fct.2014.01.033 ER - TY - JOUR T1 - Exacerbation of symptoms in agricultural pesticide applicators with asthma AN - 1524408233; 19763488 AB - Purpose: Exacerbation is a critical event in asthma management. We investigated whether exacerbation of symptoms is associated with farming exposures among agricultural pesticide applicators with asthma. Methods: Participants were pesticide applicators with active asthma (wheezing and breathing problems in past 12 months) who completed enrollment questionnaires for the Agricultural Health Study (AHS). Exacerbation of asthma was defined as having visited a hospital emergency room or doctor for an episode of wheezing or whistling in the past 12 months. Exposures of interest were using 36 specific pesticides in the past 12 months and conducting various agricultural activities. Adjusted odds ratios (ORs) were estimated by logistic regression while controlling for potential confounders. Results: The 926 AHS adult pesticide applicators with active asthma included 202 (22 %) with exacerbation. Inverse associations with exacerbation were observed for two herbicides [glyphosate, odds ratio (OR) = 0.5, 95 % confidence interval (CI) 0.3, 0.8, and paraquat, OR = 0.3, 95 % CI 0.1, 0.9] and several agricultural activities (repairing engines, grinding metal, driving diesel tractors, and performing veterinary procedures). Only asthma cases with allergies (i.e., doctor-diagnosed hay fever or eczema, 46 %) had positive exacerbation-pesticide associations, with OR = 2.1 (95 % CI 1.1, 4.1) for the herbicide pendimethalin and OR = 10.2 (95 % CI 1.9, 55) for the insecticide aldicarb. Conclusions: The inverse associations with two pesticides and specific farm activities are consistent with the possibility that asthma cases prone to exacerbation may avoid exposures that trigger symptoms. Although limited by small sample size and a cross-sectional design, our study suggests that use of specific pesticides may contribute to exacerbation of asthma among individuals with allergies. JF - International Archives of Occupational and Environmental Health AU - Henneberger, Paul K AU - Liang, Xiaoming AU - London, Stephanie J AU - Umbach, David M AU - Sandler, Dale P AU - Hoppin, Jane A AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, MS 2800, 1095 Willowdale Road, Morgantown, WV, 26505, USA, pkh0@cdc.gov Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 423 EP - 432 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 87 IS - 4 SN - 0340-0131, 0340-0131 KW - Health & Safety Science Abstracts KW - Metals KW - Farms KW - Asthma KW - Herbicides KW - Respiratory diseases KW - Allergies KW - Pendimethalin KW - Insecticides KW - Skin diseases KW - Pesticides KW - Hay fever KW - Agricultural equipment KW - Emergency medical services KW - Hospitals KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524408233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Archives+of+Occupational+and+Environmental+Health&rft.atitle=Exacerbation+of+symptoms+in+agricultural+pesticide+applicators+with+asthma&rft.au=Henneberger%2C+Paul+K%3BLiang%2C+Xiaoming%3BLondon%2C+Stephanie+J%3BUmbach%2C+David+M%3BSandler%2C+Dale+P%3BHoppin%2C+Jane+A&rft.aulast=Henneberger&rft.aufirst=Paul&rft.date=2014-05-01&rft.volume=87&rft.issue=4&rft.spage=423&rft.isbn=&rft.btitle=&rft.title=International+Archives+of+Occupational+and+Environmental+Health&rft.issn=03400131&rft_id=info:doi/10.1007%2Fs00420-013-0881-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Number of references - 30 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Metals; Farms; Asthma; Herbicides; Respiratory diseases; Allergies; Pendimethalin; Insecticides; Skin diseases; Pesticides; Hay fever; Hospitals; Emergency medical services; Agricultural equipment DO - http://dx.doi.org/10.1007/s00420-013-0881-x ER - TY - JOUR T1 - Examining occupational health and safety disparities using national data: A cause for continuing concern AN - 1520390222; 19727168 AB - Background Occupational status, a core component of socioeconomic status, plays a critical role in the well-being of U.S. workers. Identifying work-related disparities can help target prevention efforts. Methods Bureau of Labor Statistics workplace data were used to characterize high-risk occupations and examine relationships between demographic and work-related variables and fatality. Results Employment in high-injury/illness occupations was independently associated with being male, Black, less than or equal to high school degree, foreign-birth, and low-wages. Adjusted fatal occupational injury rate ratios for 2005-2009 were elevated for males, older workers, and several industries and occupations. Agriculture/forestry/fishing and mining industries and transportation and materials moving occupations had the highest rate ratios. Homicide rate ratios were elevated for Black, American Indian/Alaska Native/Asian/Pacific Islanders, and foreign-born workers. Conclusions These findings highlight the importance of understanding patterns of disparities of workplace injuries, illnesses and fatalities. Results can improve intervention efforts by developing programs that better meet the needs of the increasingly diverse U.S. workforce. Am. J. Ind. Med. 57:527-538, 2014. Published 2014. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Steege, Andrea L AU - Baron, Sherry L AU - Marsh, Suzanne M AU - Menendez, Cammie Chaumont AU - Myers, John R AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 527 EP - 538 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 5 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - occupational health disparities KW - injury KW - fatality KW - occupation KW - industry KW - race KW - ethnicity KW - nativity KW - SOII KW - CFOI KW - CPS KW - Agriculture KW - Statistics KW - Injuries KW - Occupational safety KW - Socioeconomics KW - Intervention KW - Employment KW - Demography KW - Fishing KW - Workers KW - Homicide KW - Transportation KW - Risk groups KW - Ethnic groups KW - Forestry KW - Mortality KW - Data processing KW - INE, USA, Alaska KW - Socio-economic aspects KW - Prevention KW - Occupational health KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520390222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Examining+occupational+health+and+safety+disparities+using+national+data%3A+A+cause+for+continuing+concern&rft.au=Steege%2C+Andrea+L%3BBaron%2C+Sherry+L%3BMarsh%2C+Suzanne+M%3BMenendez%2C+Cammie+Chaumont%3BMyers%2C+John+R&rft.aulast=Steege&rft.aufirst=Andrea&rft.date=2014-05-01&rft.volume=57&rft.issue=5&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22297 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Agriculture; Demography; Socio-economic aspects; Workers; Statistics; Data processing; Injuries; Risk groups; Forestry; Mortality; Occupational safety; Intervention; Socioeconomics; Employment; Fishing; Homicide; Prevention; Transportation; Ethnic groups; Occupational health; INE, USA, Alaska DO - http://dx.doi.org/10.1002/ajim.22297 ER - TY - JOUR T1 - Promoting integrated approaches to reducing health inequities among low-income workers: Applying a social ecological framework AN - 1520389845; 19727165 AB - Background Nearly one of every three workers in the United States is low-income. Low-income populations have a lower life expectancy and greater rates of chronic diseases compared to those with higher incomes. Low- income workers face hazards in their workplaces as well as in their communities. Developing integrated public health programs that address these combined health hazards, especially the interaction of occupational and non-occupational risk factors, can promote greater health equity. Methods We apply a social-ecological perspective in considering ways to improve the health of the low-income working population through integrated health protection and health promotion programs initiated in four different settings: the worksite, state and local health departments, community health centers, and community-based organizations. Results Examples of successful approaches to developing integrated programs are presented in each of these settings. These examples illustrate several complementary venues for public health programs that consider the complex interplay between work-related and non work-related factors, that integrate health protection with health promotion and that are delivered at multiple levels to improve health for low-income workers. Conclusions Whether at the workplace or in the community, employers, workers, labor and community advocates, in partnership with public health practitioners, can deliver comprehensive and integrated health protection and health promotion programs. Recommendations for improved research, training, and coordination among health departments, health practitioners, worksites and community organizations are proposed. Am. J. Ind. Med. 57:539-556, 2014. copyright 2013 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Baron, Sherry L AU - Beard, Sharon AU - Davis, Letitia K AU - Delp, Linda AU - Forst, Linda AU - Kidd-Taylor, Andrea AU - Liebman, Amy K AU - Linnan, Laura AU - Punnett, Laura AU - Welch, Laura S AD - Division of Surveillance, Hazard Evaluations, and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 539 EP - 556 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 5 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Training KW - Community involvement KW - Life span KW - Socioeconomics KW - Community organizations KW - Working conditions KW - Public health KW - Income KW - Health risks KW - USA KW - Risk factors KW - Health promotion KW - H 1000:Occupational Safety and Health KW - R2 23050:Environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520389845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Promoting+integrated+approaches+to+reducing+health+inequities+among+low-income+workers%3A+Applying+a+social+ecological+framework&rft.au=Baron%2C+Sherry+L%3BBeard%2C+Sharon%3BDavis%2C+Letitia+K%3BDelp%2C+Linda%3BForst%2C+Linda%3BKidd-Taylor%2C+Andrea%3BLiebman%2C+Amy+K%3BLinnan%2C+Laura%3BPunnett%2C+Laura%3BWelch%2C+Laura+S&rft.aulast=Baron&rft.aufirst=Sherry&rft.date=2014-05-01&rft.volume=57&rft.issue=5&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22174 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2014-05-29 N1 - SubjectsTermNotLitGenreText - Health risks; Training; Community involvement; Risk factors; Life span; Socioeconomics; Community organizations; Working conditions; Income; Health promotion; Public health; USA DO - http://dx.doi.org/10.1002/ajim.22174 ER - TY - JOUR T1 - Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol-17 beta levels in zebrafish early life stages AN - 1520383165; 19553357 AB - Ketamine, a dissociative anesthetic, is a noncompetitive antagonist of N-methyl-D-aspartate-type glutamate receptors. In rodents and non-human primates as well as in zebrafish embryos, ketamine has been shown to be neurotoxic. In cyclic female rats, ketamine has been shown to decrease serum estradiol-17 beta (E2) levels. E2 plays critical roles in neurodevelopment and neuroprotection. Cytochrome p450 (CYP) aromatase catalyzes E2 synthesis from androgens. Although ketamine down-regulates a number of CYP enzymes in rodents, its effect on the CYP aromatase (CYP19) is not known. Zebrafish have been used as a model system for examining mechanisms underlying drug effects. Here, using wild-type (WT) zebrafish (Danio rerio) embryos, we demonstrate that ketamine significantly reduced E2 levels compared with the control. However, the testosterone level was elevated in ketamine-treated embryos. These results are concordant with data from mammalian studies. Ketamine also attenuated the expression of the ovary form of CYP aromatase (cyp19a1a) at the transcriptional level but not the brain form of aromatase, cyp19a1b. Exogenous E2 potently induced the expression of cyp19a1b and vtg 1, both validated biomarkers of estrogenicity and endocrine disruption, but not cyp19a1a expression. Attenuation of activated ERK/MAPK levels, reportedly responsible for reduced human cyp19 transcription, was also observed in ketamine-treated embryos. These results suggest that reduced E2 levels in ketamine-treated embryos may have resulted from the suppression of cyp19a1a transcription. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. Ketamine attenuates aromatase gene expression and estrogen levels in zebrafish embryos. JF - Journal of Applied Toxicology AU - Trickler, William J AU - Guo, Xiaoqing AU - Cuevas, Elvis AU - Ali, Syed F AU - Paule, Merle G AU - Kanungo, Jyotshna AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR road, Jefferson, AR, 72079, USA. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 480 EP - 488 PB - Wiley Subscription Services, Inc., 1105 N Market St Wilmington DE 19801 VL - 34 IS - 5 SN - 0260-437X, 0260-437X KW - Genetics Abstracts; Pollution Abstracts; Aqualine Abstracts; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Toxicology Abstracts KW - ketamine KW - zebrafish KW - estradiol-17[beta] KW - CYP aromatase KW - gene expression KW - testosterone KW - Cytochromes KW - Endocrine disruptors KW - Anesthetics KW - Biomarkers KW - Freshwater KW - Freshwater fish KW - Sex hormones KW - Gene expression KW - Extracellular signal-regulated kinase KW - Aromatase KW - Ketamine KW - Embryos KW - Synthesis KW - Bioindicators KW - Brain KW - Receptors KW - Developmental stages KW - Transcription KW - Fish (cyprinid) (minnow or carp family) (continued) KW - Primates KW - Glutamic acid receptors KW - Model Studies KW - Danio rerio KW - Testosterone KW - Cytochrome KW - Water Pollution Effects KW - Endocrinology KW - Neurotoxicity KW - Cytochrome P450 KW - N-Methyl-D-aspartic acid receptors KW - Rats KW - Drugs KW - Rodents KW - MAP kinase KW - Estrogens KW - Enzymes KW - Toxicity KW - biomarkers KW - USA KW - Q5 08503:Characteristics, behavior and fate KW - SW 3040:Wastewater treatment processes KW - X 24310:Pharmaceuticals KW - AQ 00008:Effects of Pollution KW - G 07870:Mammals KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520383165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Applied+Toxicology&rft.atitle=Ketamine+attenuates+cytochrome+p450+aromatase+gene+expression+and+estradiol-17+beta+levels+in+zebrafish+early+life+stages&rft.au=Trickler%2C+William+J%3BGuo%2C+Xiaoqing%3BCuevas%2C+Elvis%3BAli%2C+Syed+F%3BPaule%2C+Merle+G%3BKanungo%2C+Jyotshna&rft.aulast=Trickler&rft.aufirst=William&rft.date=2014-05-01&rft.volume=34&rft.issue=5&rft.spage=480&rft.isbn=&rft.btitle=&rft.title=Journal+of+Applied+Toxicology&rft.issn=0260437X&rft_id=info:doi/10.1002%2Fjat.2888 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2016-09-29 N1 - SubjectsTermNotLitGenreText - Gene expression; Cytochromes; Endocrinology; Receptors; Brain; Transcription; Biomarkers; Freshwater fish; Sex hormones; Estrogens; MAP kinase; N-Methyl-D-aspartic acid receptors; Endocrine disruptors; Anesthetics; Enzymes; Developmental stages; biomarkers; Glutamic acid receptors; Extracellular signal-regulated kinase; Testosterone; Aromatase; Neurotoxicity; Ketamine; Embryos; Cytochrome P450; Drugs; Rats; Bioindicators; Cytochrome; Primates; Rodents; Water Pollution Effects; Toxicity; Synthesis; Fish (cyprinid) (minnow or carp family) (continued); Model Studies; Danio rerio; USA; Freshwater DO - http://dx.doi.org/10.1002/jat.2888 ER - TY - JOUR T1 - Prevalence and diversity of enterotoxigenic Escherichia coli strains in fresh produce. AN - 1520354653; 24780338 AB - Analysis of fresh produce showed that enterotoxigenic Escherichia coli (ETEC) strains are most often found in cilantro and parsley, with prevalence rates of approximately 0.3%. Some ETEC strains also carried Shiga toxigenic E. coli (STEC) genes but had no STEC adherence factors, which are essential to cause severe human illness. Most ETEC strains in produce carried stable toxin and/or labile toxin genes but belonged to unremarkable serotypes that have not been reported to have caused human illnesses. JF - Journal of food protection AU - Feng, Peter C H AU - Reddy, Shanker P AD - Division of Microbiology, U.S. Food and Drug Administration, College Park, Maryland, 20740, USA. peter.feng@fda.hhs.gov. ; Agricultural Marketing Service, U.S. Department of Agriculture, Washington, D.C. 20250, USA. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 820 EP - 823 VL - 77 IS - 5 KW - Index Medicus KW - Humans KW - Prevalence KW - Vegetables -- microbiology KW - Fruit -- microbiology KW - Food Contamination -- statistics & numerical data KW - Food Contamination -- analysis KW - Biodiversity KW - Enterotoxigenic Escherichia coli -- genetics KW - Enterotoxigenic Escherichia coli -- classification KW - Enterotoxigenic Escherichia coli -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520354653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+food+protection&rft.atitle=Prevalence+and+diversity+of+enterotoxigenic+Escherichia+coli+strains+in+fresh+produce.&rft.au=Feng%2C+Peter+C+H%3BReddy%2C+Shanker+P&rft.aulast=Feng&rft.aufirst=Peter+C&rft.date=2014-05-01&rft.volume=77&rft.issue=5&rft.spage=820&rft.isbn=&rft.btitle=&rft.title=Journal+of+food+protection&rft.issn=1944-9097&rft_id=info:doi/10.4315%2F0362-028X.JFP-13-412 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-06 N1 - Date created - 2014-04-30 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.4315/0362-028X.JFP-13-412 ER - TY - JOUR T1 - Porcine brain microvessel endothelial cells show pro-inflammatory response to the size and composition of metallic nanoparticles. AN - 1518813002; 24378227 AB - The purpose of the current studies was to determine if systemic exposure of various metallic nanoparticles differing in size and composition [silver (Ag-NPs, 25, 40 and 80 nm), copper-oxide (Cu-NPs, 40 and 60 nm) or gold (Au-NPs, 3 and 5 nm)] can induce the release of pro-inflammatory mediators that influence the restrictive nature of the blood-brain barrier (BBB) in vitro. Confluent porcine brain microvessel endothelial cells (pBMECs) (8-12 days) were treated with various metallic nanoparticles (15 μg/ml). Extracellular concentrations of pro-inflammatory mediators (IL-1β, TNFα and PGE2) were evaluated using ELISA. pBMECs were cultured in standard 12-well Transwell® inserts, and permeability was evaluated by measuring the transport of fluorescein across the pBMEC monolayers. PGE2 release following Cu-NP exposure was significantly increased when compared to the control. Similar results were observed for Ag-NPs but not Au-NPs. The secretion of TNFα and IL-1β was observed for both Cu-NPs and Ag-NPs but not in response to Au-NPs. The post-treatment time profiles of TNFα and IL-1β revealed that the IL-1β response was more persistent. The permeability ratios (exposure/control) were significantly greater following exposure to Cu-NPs or Ag-NPs, compared to Au-NPs. Together, these data suggest that the composition and size of NPs can cause significant pro-inflammatory response that can influence the integrity of the BBB. JF - Drug metabolism reviews AU - Trickler, William J AU - Lantz-McPeak, Susan M AU - Robinson, Bonnie L AU - Paule, Merle G AU - Slikker, William AU - Biris, Alexandru S AU - Schlager, John J AU - Hussain, Saber M AU - Kanungo, Jyotshna AU - Gonzalez, Carmen AU - Ali, Syed F AD - Division of Neurotoxicology, National Center for Toxicological Research, US Food and Drug Administration , Jefferson, AR , USA . Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 224 EP - 231 VL - 46 IS - 2 KW - Inflammation Mediators KW - 0 KW - Interleukin-1beta KW - Tumor Necrosis Factor-alpha KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Swine KW - Dinoprostone -- immunology KW - Animals KW - Particle Size KW - Interleukin-1beta -- secretion KW - Tumor Necrosis Factor-alpha -- immunology KW - Neurotoxicity Syndromes -- etiology KW - Dinoprostone -- secretion KW - Tumor Necrosis Factor-alpha -- secretion KW - Interleukin-1beta -- immunology KW - Surface Properties KW - Neurotoxicity Syndromes -- immunology KW - Blood-Brain Barrier -- drug effects KW - Endothelial Cells -- drug effects KW - Blood-Brain Barrier -- cytology KW - Metal Nanoparticles -- toxicity KW - Metal Nanoparticles -- chemistry KW - Microvessels -- drug effects KW - Microvessels -- immunology KW - Inflammation Mediators -- immunology KW - Blood-Brain Barrier -- immunology KW - Endothelial Cells -- immunology KW - Microvessels -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518813002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+reviews&rft.atitle=Porcine+brain+microvessel+endothelial+cells+show+pro-inflammatory+response+to+the+size+and+composition+of+metallic+nanoparticles.&rft.au=Trickler%2C+William+J%3BLantz-McPeak%2C+Susan+M%3BRobinson%2C+Bonnie+L%3BPaule%2C+Merle+G%3BSlikker%2C+William%3BBiris%2C+Alexandru+S%3BSchlager%2C+John+J%3BHussain%2C+Saber+M%3BKanungo%2C+Jyotshna%3BGonzalez%2C+Carmen%3BAli%2C+Syed+F&rft.aulast=Trickler&rft.aufirst=William&rft.date=2014-05-01&rft.volume=46&rft.issue=2&rft.spage=224&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+reviews&rft.issn=1097-9883&rft_id=info:doi/10.3109%2F03602532.2013.873450 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-09 N1 - Date created - 2014-04-23 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/03602532.2013.873450 ER - TY - JOUR T1 - Seafood consumption and blood mercury concentrations in adults aged ≥20 y, 2007-2010. AN - 1518243303; 24522443 AB - Seafood is part of a healthy diet, but seafood can also contain methyl mercury-a neurotoxin. The objective was to describe seafood consumption in US adults and to explore the relation between seafood consumption and blood mercury. Seafood consumption, obtained from a food-frequency questionnaire, and blood mercury data were available for 10,673 adults who participated in the 2007-2010 NHANES-a cross-sectional nationally representative sample of the US population. Seafood consumption was categorized by type (fish or shellfish) and by frequency of consumption (0, 1-2, 3-4, or ≥5 times/mo). Linear trends in geometric mean blood mercury concentrations by frequency of seafood consumption were tested. Logistic regression analyses examined the odds of blood mercury concentrations ≥5.8 μg/L (as identified by the National Research Council) based on frequency of the specific type of seafood consumed (included in the model as continuous variables) adjusted for sex, age, and race/Hispanic origin. In 2007-2010, 83.0% ± 0.7% (±SE) of adults consumed seafood in the preceding month. In adults consuming seafood, the blood mercury concentration increased as the frequency of seafood consumption increased (P < 0.001). In 2007-2010, 4.6% ± 0.39% of adults had blood mercury concentrations ≥5.8 μg/L. Results of the logistic regression on blood mercury concentrations ≥5.8 μg/L showed no association with shrimp (P = 0.21) or crab (P = 0.48) consumption and a highly significant positive association with consumption of high-mercury fish (adjusted OR per unit monthly consumption: 4.58; 95% CI: 2.44, 8.62; P < 0.001), tuna (adjusted OR: 1.14; 95% CI: 1.10, 1.17; P < 0.001), salmon (adjusted OR: 1.14; 95% CI: 1.09, 1.20; P < 0.001), and other seafood (adjusted OR: 1.12; 95% CI: 1.08, 1.15; P < 0.001). Most US adults consume seafood, and the blood mercury concentration is associated with the consumption of tuna, salmon, high-mercury fish, and other seafood. JF - The American journal of clinical nutrition AU - Nielsen, Samara Joy AU - Kit, Brian K AU - Aoki, Yutaka AU - Ogden, Cynthia L AD - Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, CDC, Hyattsville, MD (SJN, BKK, YA, and CLO), and the US Public Health Service, Rockville, MD (BKK). Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 1066 EP - 1070 VL - 99 IS - 5 KW - Mercury KW - FXS1BY2PGL KW - Abridged Index Medicus KW - Index Medicus KW - Young Adult KW - Cross-Sectional Studies KW - Animals KW - Logistic Models KW - Humans KW - Food Contamination -- analysis KW - Adult KW - Surveys and Questionnaires KW - Nutrition Surveys KW - Middle Aged KW - Male KW - Female KW - Mercury -- blood KW - Environmental Exposure -- analysis KW - Seafood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518243303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Seafood+consumption+and+blood+mercury+concentrations+in+adults+aged+%E2%89%A520+y%2C+2007-2010.&rft.au=Nielsen%2C+Samara+Joy%3BKit%2C+Brian+K%3BAoki%2C+Yutaka%3BOgden%2C+Cynthia+L&rft.aulast=Nielsen&rft.aufirst=Samara&rft.date=2014-05-01&rft.volume=99&rft.issue=5&rft.spage=1066&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=1938-3207&rft_id=info:doi/10.3945%2Fajcn.113.077081 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-06-10 N1 - Date created - 2014-04-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: Am J Clin Nutr. 2014 May;99(5):973-4 [24670941] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3945/ajcn.113.077081 ER - TY - JOUR T1 - Comparison of life-stage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague Dawley rats. AN - 1518243141; 24496641 AB - Bisphenol A (BPA) was administered by gavage (2.5-300,000 μg/kg body weight (bw)/day) to pregnant Sprague Dawley dams, newborn pups, and continuing into adulthood. Aglycone (i.e., unconjugated and active) and conjugated (i.e., inactive) BPA were evaluated by liquid chromatography electrospray tandem mass spectrometry (LC-ES/MS/MS) in serum to better interpret toxicological endpoints measured in the study. Ethinyl estradiol (EE2, 0.5 and 5 μg/kg bw/day) and the endogenous hormones, 17β-estradiol (E2) and testosterone, were similarly evaluated. Mean BPA aglycone levels in vehicle and naïve control rat serum (0.02-0.5 ng/ml) indicated sample processing artifact, consistent with literature reports of a propensity for postexposure blood contamination by BPA. Direct measurements of BPA-glucuronide in vehicle and naïve control serum (2-10nM) indicated unintentional exposure and metabolism at levels similar to those produced by 2.5 μg/kg bw/day BPA (7-10nM), despite careful attention to potential BPA inputs (diet, drinking water, vehicle, cages, bedding, and dust) and rigorous dosing solution certification and delivery. The source of this exposure could not be identified, but interpretation of the toxicological effects, observed only at the highest BPA doses, was not compromised. Internal exposures to BPA and EE2 aglycones were highest in young rats. When maximal serum concentrations from the two highest BPA doses and both EE2 doses were compared with concurrent levels of endogenous E2, the ERα binding equivalents were similar to or above those of endogenous E2 in male and female rats of all ages tested. Such evaluations of estrogenic internal dosimetry and comprehensive evaluation of contamination impact should aid in extrapolating risks from human BPA exposures. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Churchwell, Mona I AU - Camacho, Luísa AU - Vanlandingham, Michelle M AU - Twaddle, Nathan C AU - Sepehr, Estatira AU - Delclos, K Barry AU - Fisher, Jeffrey W AU - Doerge, Daniel R AD - U.S. Food and Drug Administration, National Center for Toxicological Research, Division of Biochemical Toxicology, 3900 NCTR Road, Jefferson, Arkansas 72079. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 4 EP - 20 VL - 139 IS - 1 KW - Benzhydryl Compounds KW - 0 KW - Phenols KW - Ethinyl Estradiol KW - 423D2T571U KW - Estradiol KW - 4TI98Z838E KW - bisphenol A KW - MLT3645I99 KW - Index Medicus KW - ethinyl estradiol KW - mass spectrometry KW - pharmacokinetics KW - estrogen receptor KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Tandem Mass Spectrometry KW - Male KW - Female KW - Chromatography, High Pressure Liquid KW - Benzhydryl Compounds -- toxicity KW - Benzhydryl Compounds -- pharmacokinetics KW - Phenols -- pharmacokinetics KW - Estradiol -- physiology KW - Phenols -- toxicity KW - Ethinyl Estradiol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518243141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Comparison+of+life-stage-dependent+internal+dosimetry+for+bisphenol+A%2C+ethinyl+estradiol%2C+a+reference+estrogen%2C+and+endogenous+estradiol+to+test+an+estrogenic+mode+of+action+in+Sprague+Dawley+rats.&rft.au=Churchwell%2C+Mona+I%3BCamacho%2C+Lu%C3%ADsa%3BVanlandingham%2C+Michelle+M%3BTwaddle%2C+Nathan+C%3BSepehr%2C+Estatira%3BDelclos%2C+K+Barry%3BFisher%2C+Jeffrey+W%3BDoerge%2C+Daniel+R&rft.aulast=Churchwell&rft.aufirst=Mona&rft.date=2014-05-01&rft.volume=139&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkfu021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-28 N1 - Date created - 2014-04-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 2013 Feb 15;267(1):41-8 [23261975] Toxicol Appl Pharmacol. 1992 Feb;112(2):300-9 [1539166] Rev Environ Health. 2013;28(1):37-58 [23612528] Toxicol Appl Pharmacol. 2013 Jul 1;270(1):45-59 [23566954] Environ Health Perspect. 2013 Jul;121(7):A206-7 [23817036] Environ Health Perspect. 2013 Sep;121(9):1040-6 [23876597] Food Chem Toxicol. 2013 Dec;62:935-48 [23867546] Food Chem Toxicol. 2013 Dec;62:949-63 [23959105] Breast Cancer Res. 2013;15(5):403 [24083327] Toxicol Sci. 2014 May;139(1):174-97 [24496637] J Clin Invest. 1994 Dec;94(6):2475-80 [7989605] Carcinogenesis. 1997 Aug;18(8):1505-10 [9276623] Toxicol Sci. 2005 Jun;85(2):823-38 [15746009] J Steroid Biochem Mol Biol. 2006 Dec;102(1-5):175-9 [17088055] Cancer Epidemiol Biomarkers Prev. 2007 May;16(5):1004-8 [17507629] Reprod Toxicol. 2007 Aug-Sep;24(2):199-224 [17683900] Anal Chem. 2007 Oct 15;79(20):7813-21 [17848096] Environ Health Perspect. 2008 Jan;116(1):39-44 [18197297] Am J Clin Pathol. 2008 Apr;129(4):530-9 [18343779] J Comp Neurol. 2009 Feb 10;512(5):688-701 [19051266] Environ Health Perspect. 2009 May;117(5):784-9 [19479022] Philos Trans R Soc Lond B Biol Sci. 2009 Jul 27;364(1526):2063-78 [19528056] Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):292-300 [20056650] Biomed Chromatogr. 2010 Feb;24(2):160-8 [19591119] Toxicol Sci. 2010 May;115(1):167-82 [20164145] J Anal Toxicol. 2010 Jul-Aug;34(6):293-303 [20663281] Environ Health Perspect. 2010 Aug;118(8):1055-70 [20338858] Toxicol Appl Pharmacol. 2010 Sep 1;247(2):158-65 [20600215] J Expo Sci Environ Epidemiol. 2012 Nov;22(6):610-6 [22617719] Toxicol Appl Pharmacol. 2010 Oct 1;248(1):1-11 [20655935] Rapid Commun Mass Spectrom. 2010 Oct 30;24(20):3011-20 [20872634] Reprod Toxicol. 2011 Jan;31(1):1-9 [20887781] J Biol Chem. 2011 Apr 15;286(15):12971-82 [21321128] Environ Res. 2011 Aug;111(6):761-4 [21684541] Toxicol Appl Pharmacol. 2011 Sep 15;255(3):261-70 [21820460] Toxicol Sci. 2011 Sep;123(1):48-57 [21705716] Endocrinology. 2011 Nov;152(11):4443-7 [21933867] Toxicol Lett. 2011 Dec 15;207(3):298-305 [21983029] Toxicol Appl Pharmacol. 2011 Nov 15;257(1):122-36 [21920375] J Expo Sci Environ Epidemiol. 2012 May-Jun;22(3):219-26 [22333730] Eur J Endocrinol. 2012 Jun;166(6):983-91 [22423144] Arch Toxicol. 2001 Mar;75(1):62-4 [11357523] Toxicology. 2001 Sep 14;166(1-2):79-89 [11518614] Toxicol Sci. 2002 Jul;68(1):121-46 [12075117] Toxicol Sci. 2002 Sep;69(1):60-78 [12215661] Chem Res Toxicol. 2002 Oct;15(10):1281-7 [12387626] J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Aug 15;793(2):309-15 [12906905] Risk Anal. 2004 Jun;24(3):751-70 [15209943] Endocr Rev. 1989 Aug;10(3):232-74 [2673754] J Steroid Biochem. 1990 Feb;35(2):313-8 [2308344] Environ Health Perspect. 2013 Mar;121(3):283-6 [23458838] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kfu021 ER - TY - JOUR T1 - Improving the assessment of heart toxicity for all new drugs through translational regulatory science. AN - 1518242773; 24336137 AB - Fourteen drugs have been removed from the market worldwide because they cause torsade de pointes. Most drugs that cause torsade can be identified by assessing whether they block the human ether à gogo related gene (hERG) potassium channel and prolong the QT interval on the electrocardiogram. In response, regulatory agencies require new drugs to undergo "thorough QT" studies. However, some drugs block hERG potassium channels and prolong QT with minimal torsade risk because they also block calcium and/or sodium channels. Through analysis of clinical and preclinical data from 34 studies submitted to the US Food and Drug Administration and by computer simulations, we demonstrate that by dividing the QT interval into its components of depolarization (QRS), early repolarization (J-Tpeak), and late repolarization (Tpeak-Tend), along with atrioventricular conduction delay (PR), it may be possible to determine which hERG potassium channel blockers also have calcium and/or sodium channel blocking activity. This translational regulatory science approach may enable innovative drugs that otherwise would have been labeled unsafe to come to market. JF - Clinical pharmacology and therapeutics AU - Johannesen, L AU - Vicente, J AU - Gray, R A AU - Galeotti, L AU - Loring, Z AU - Garnett, C E AU - Florian, J AU - Ugander, M AU - Stockbridge, N AU - Strauss, D G AD - 1] Division of Pharmacometrics, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA [2] Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, USA [3] Department of Clinical Physiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. ; 1] Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, USA [2] Communications Technology Group, Aragón Institute of Engineering Research, IIS Aragón, University of Zaragoza, Zaragoza, Spain. ; Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, USA. ; 1] Division of Pharmacometrics, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA [2] Certara, Cary, North Carolina, USA. ; Division of Pharmacometrics, Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. ; 1] Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, Maryland, USA [2] Department of Clinical Physiology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden. ; Division of Cardiovascular and Renal Products, Office of New Drugs, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 501 EP - 508 VL - 95 IS - 5 KW - Calcium Channel Blockers KW - 0 KW - Potassium Channel Blockers KW - Sodium Channel Blockers KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Drug and Narcotic Control KW - Humans KW - Electrocardiography KW - Drug Approval KW - Calcium Channel Blockers -- adverse effects KW - Clinical Trials as Topic KW - Potassium Channel Blockers -- adverse effects KW - Sodium Channel Blockers -- adverse effects KW - Drug Evaluation, Preclinical KW - Long QT Syndrome -- chemically induced KW - Computer Simulation KW - Translational Medical Research -- methods KW - Torsades de Pointes -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518242773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Improving+the+assessment+of+heart+toxicity+for+all+new+drugs+through+translational+regulatory+science.&rft.au=Johannesen%2C+L%3BVicente%2C+J%3BGray%2C+R+A%3BGaleotti%2C+L%3BLoring%2C+Z%3BGarnett%2C+C+E%3BFlorian%2C+J%3BUgander%2C+M%3BStockbridge%2C+N%3BStrauss%2C+D+G&rft.aulast=Johannesen&rft.aufirst=L&rft.date=2014-05-01&rft.volume=95&rft.issue=5&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2013.238 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-06-04 N1 - Date created - 2014-04-21 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/clpt.2013.238 ER - TY - JOUR T1 - Exploring the FDA adverse event reporting system to generate hypotheses for monitoring of disease characteristics. AN - 1518242608; 24448476 AB - The US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) is a database for postmarketing drug safety monitoring and influences changes in FDA safety guidance documents such as drug labels. The number of cases in the FAERS has rapidly increased with the improvement of submission methods and data standards and thus has become an important resource for regulatory science. Although the FAERS has been predominantly used for safety signal detection, this study explored its utility for disease characteristics. JF - Clinical pharmacology and therapeutics AU - Fang, H AU - Su, Z AU - Wang, Y AU - Miller, A AU - Liu, Z AU - Howard, P C AU - Tong, W AU - Lin, S M AD - Office of Scientific Coordination, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA. ; Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA. ; Biomedical Informatics Research Center, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 496 EP - 498 VL - 95 IS - 5 KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Data Mining KW - Humans KW - Databases, Factual KW - Drug Labeling KW - Product Surveillance, Postmarketing -- methods KW - Adverse Drug Reaction Reporting Systems KW - Drug-Related Side Effects and Adverse Reactions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518242608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacology+and+therapeutics&rft.atitle=Exploring+the+FDA+adverse+event+reporting+system+to+generate+hypotheses+for+monitoring+of+disease+characteristics.&rft.au=Fang%2C+H%3BSu%2C+Z%3BWang%2C+Y%3BMiller%2C+A%3BLiu%2C+Z%3BHoward%2C+P+C%3BTong%2C+W%3BLin%2C+S+M&rft.aulast=Fang&rft.aufirst=H&rft.date=2014-05-01&rft.volume=95&rft.issue=5&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacology+and+therapeutics&rft.issn=1532-6535&rft_id=info:doi/10.1038%2Fclpt.2014.17 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-06-04 N1 - Date created - 2014-04-21 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Br J Dermatol. 2001 Jul;145(1):100-4 [11453915] Nat Immunol. 2001 Sep;2(9):777-80 [11526384] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D267-70 [14681409] Nat Biotechnol. 2009 Jul;27(7):601-2 [19587659] Anesthesiology. 2012 Jan;116(1):15-24 [22185873] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/clpt.2014.17 ER - TY - JOUR T1 - Using public health scenarios to predict the utility of a national syndromic surveillance programme during the 2012 London Olympic and Paralympic Games AN - 1516741091; 19544276 AB - During 2012 real-time syndromic surveillance formed a key part of the daily public health surveillance for the London Olympic and Paralympic Games. It was vital that these systems were evaluated prior to the Games; in particular what types and scales of incidents could and could not be detected. Different public health scenarios were created covering a range of potential incidents that the Health Protection Agency would require syndromic surveillance to rapidly detect and monitor. For the scenarios considered it is now possible to determine what is likely to be detectable and how incidents are likely to present using the different syndromic systems. Small localized incidents involving food poisoning are most likely to be detected the next day via emergency department surveillance, while a new strain of influenza is more likely to be detected via GP or telephone helpline surveillance, several weeks after the first seed case is introduced. JF - Epidemiology and Infection AU - Morbey, R A AU - Elliot, A J AU - CHARLETT, A AU - Ibbotson, S AU - Verlander, N Q AU - Leach, S AU - Hall, I AU - Barrass, I AU - Catchpole, M AU - McCLOSKEY, B AU - Said, B AU - Walsh, A AU - PEBODY, R AU - Smith, Ge AD - Health Protection Agency (HPA), Real-time Syndromic Surveillance Team, Health Protection Services, Birmingham, UK, Roger.Morbey@phe.gov.uk Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 984 EP - 993 PB - Cambridge University Press, The Edinburgh Building, Cambridge CB2 2RU United Kingdom VL - 142 IS - 5 SN - 0950-2688, 0950-2688 KW - Health & Safety Science Abstracts KW - Influenza KW - British Isles, England, Greater London, London KW - Food contamination KW - Public health KW - Emergency medical services KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516741091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+and+Infection&rft.atitle=Using+public+health+scenarios+to+predict+the+utility+of+a+national+syndromic+surveillance+programme+during+the+2012+London+Olympic+and+Paralympic+Games&rft.au=Morbey%2C+R+A%3BElliot%2C+A+J%3BCHARLETT%2C+A%3BIbbotson%2C+S%3BVerlander%2C+N+Q%3BLeach%2C+S%3BHall%2C+I%3BBarrass%2C+I%3BCatchpole%2C+M%3BMcCLOSKEY%2C+B%3BSaid%2C+B%3BWalsh%2C+A%3BPEBODY%2C+R%3BSmith%2C+Ge&rft.aulast=Morbey&rft.aufirst=R&rft.date=2014-05-01&rft.volume=142&rft.issue=5&rft.spage=984&rft.isbn=&rft.btitle=&rft.title=Epidemiology+and+Infection&rft.issn=09502688&rft_id=info:doi/10.1017%2FS095026881300188X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 7 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Influenza; Food contamination; Emergency medical services; Public health; British Isles, England, Greater London, London DO - http://dx.doi.org/10.1017/S095026881300188X ER - TY - JOUR T1 - Evidence for a role of transporter-mediated currents in the depletion of brain serotonin induced by serotonin transporter substrates. AN - 1516724569; 24287719 AB - Serotonin (5-HT) transporter (SERT) substrates like fenfluramine and 3,4-methylenedioxymethamphetamine cause long-term depletion of brain 5-HT, while certain other substrates do not. The 5-HT deficits produced by SERT substrates are dependent upon transporter proteins, but the exact mechanisms responsible are unclear. Here, we compared the pharmacology of several SERT substrates: fenfluramine, d-fenfluramine, 1-(m-chlorophenyl)piperazine (mCPP) and 1-(m-trifluoromethylphenyl)piperainze (TFMPP), to establish relationships between acute drug mechanisms and the propensity for long-term 5-HT depletions. In vivo microdialysis was carried out in rat nucleus accumbens to examine acute 5-HT release and long-term depletion in the same subjects. In vitro assays were performed to measure efflux of [(3)H]5-HT in rat brain synaptosomes and transporter-mediated ionic currents in SERT-expressing Xenopus oocytes. When administered repeatedly to rats (6 mg/kg, i.p., four doses), all drugs produce large sustained elevations in extracellular 5-HT (>5-fold) with minimal effects on dopamine. Importantly, 2 weeks after dosing, only rats exposed to fenfluramine and d-fenfluramine display depletion of brain 5-HT. All test drugs evoke fluoxetine-sensitive efflux of [(3)H]5-HT from synaptosomes, but d-fenfluramine and its bioactive metabolite d-norfenfluramine induce significantly greater SERT-mediated currents than phenylpiperazines. Our data confirm that drug-induced 5-HT release probably does not mediate 5-HT depletion. However, the magnitude of transporter-mediated inward current may be a critical factor in the cascade of events leading to 5-HT deficits. This hypothesis warrants further study, especially given the growing popularity of designer drugs that target SERT. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Baumann, Michael H AU - Bulling, Simon AU - Benaderet, Tova S AU - Saha, Kusumika AU - Ayestas, Mario A AU - Partilla, John S AU - Ali, Syed F AU - Stockner, Thomas AU - Rothman, Richard B AU - Sandtner, Walter AU - Sitte, Harald H AD - Medicinal Chemistry Section, Intramural Research Program (IRP), NIDA, NIH, Baltimore, MD, USA. ; Center for Physiology and Pharmacology, Institute of Pharmacology, Medical University Vienna, Vienna, Austria. ; Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research (NCTR), FDA, Jefferson, AR, USA. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - 1355 EP - 1365 VL - 39 IS - 6 KW - Piperazines KW - 0 KW - Serotonin Agents KW - Serotonin Plasma Membrane Transport Proteins KW - Slc6a4 protein, rat KW - 1-(3-trifluoromethylphenyl)piperazine KW - 25R3ONU51C KW - Fenfluramine KW - 2DS058H2CF KW - Serotonin KW - 333DO1RDJY KW - 1-(3-chlorophenyl)piperazine KW - REY0CNO998 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Synaptosomes -- drug effects KW - Nucleus Accumbens -- drug effects KW - Dopamine -- metabolism KW - Fenfluramine -- pharmacology KW - Piperazines -- pharmacology KW - Rats KW - Xenopus laevis KW - Rats, Sprague-Dawley KW - Extracellular Space -- metabolism KW - Nucleus Accumbens -- metabolism KW - Membrane Potentials -- drug effects KW - Time Factors KW - Synaptosomes -- metabolism KW - Male KW - Serotonin Plasma Membrane Transport Proteins -- metabolism KW - Serotonin Agents -- pharmacology KW - Brain -- drug effects KW - Brain -- metabolism KW - Serotonin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516724569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Evidence+for+a+role+of+transporter-mediated+currents+in+the+depletion+of+brain+serotonin+induced+by+serotonin+transporter+substrates.&rft.au=Baumann%2C+Michael+H%3BBulling%2C+Simon%3BBenaderet%2C+Tova+S%3BSaha%2C+Kusumika%3BAyestas%2C+Mario+A%3BPartilla%2C+John+S%3BAli%2C+Syed+F%3BStockner%2C+Thomas%3BRothman%2C+Richard+B%3BSandtner%2C+Walter%3BSitte%2C+Harald+H&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2014-05-01&rft.volume=39&rft.issue=6&rft.spage=1355&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=1740-634X&rft_id=info:doi/10.1038%2Fnpp.2013.331 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-15 N1 - Date created - 2014-04-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Nov 26;279(48):49671-9 [15358780] J Pharmacol Exp Ther. 1994 Aug;270(2):741-51 [8071867] Psychopharmacology (Berl). 1994 Dec;116(4):508-14 [7535469] NIDA Res Monogr. 1996;163:251-76 [8809863] Brain Res. 1996 Aug 19;730(1-2):165-72 [8883900] Neuropharmacology. 1996;35(11):1615-20 [9025109] Br J Pharmacol. 1997 Jul;121(5):889-900 [9222545] N Engl J Med. 1997 Aug 28;337(9):581-8 [9271479] JAMA. 1997 Aug 27;278(8):666-72 [9272900] Brain Res. 1997 Aug 8;765(1):101-7 [9310399] Neurochem Int. 1998 Feb;32(2):117-31 [9542724] Neuropsychopharmacology. 2005 Mar;30(3):550-60 [15496938] J Pharmacol Exp Ther. 2005 Apr;313(1):422-31 [15634943] J Pharmacol Exp Ther. 2005 Jun;313(3):1361-9 [15761112] Neuropharmacology. 2005 Nov;49(6):811-9 [16185723] Neuropsychopharmacology. 2006 Dec;31(12):2639-51 [16452989] J Neurochem. 2000 Mar;74(3):1317-24 [10693966] Eur J Pharmacol. 2000 Mar 3;390(3):275-85 [10708734] J Neurosci. 2000 May 1;20(9):3504-11 [10777813] Synapse. 2001 Jan;39(1):32-41 [11071707] Circulation. 2000 Dec 5;102(23):2836-41 [11104741] Neuropsychopharmacology. 2001 May;24(5):492-501 [11282249] Chem Res Toxicol. 2001 Sep;14(9):1184-92 [11559032] Pharmacol Toxicol. 2001 Nov;89(5):237-48 [11881977] Pharmacol Ther. 2002 Jul;95(1):73-88 [12163129] Nat Neurosci. 2002 Oct;5(10):971-8 [12352983] Brain Res Brain Res Rev. 2003 May;42(2):155-68 [12738056] J Pharmacol Exp Ther. 2003 Jun;305(3):1191-9 [12649307] Biophys J. 2003 Sep;85(3):1548-59 [12944272] Biochem Pharmacol. 2004 Jan 15;67(2):235-44 [14698036] J Pharmacol Exp Ther. 1975 Jan;192(1):33-41 [1123726] Postgrad Med J. 1975;51 Suppl 1:27-35 [768968] Postgrad Med J. 1975;51 Suppl 1:35-45 [1219678] Ann N Y Acad Sci. 1978 Jun 12;305:222-41 [309298] Neuropharmacology. 1979 Nov;18(11):895-903 [95210] Br J Pharmacol. 1982 Mar;75(3):525-30 [6175368] Biochem Pharmacol. 1984 May 1;33(9):1531-5 [6610423] J Pharmacol Exp Ther. 1987 Apr;241(1):338-45 [2883295] Brain Res. 1989 Mar 20;482(2):261-70 [2468397] Naunyn Schmiedebergs Arch Pharmacol. 1989 Jun;339(6):675-83 [2770889] Brain Res. 1989 Dec 29;505(2):351-3 [2598057] J Med Chem. 1990 Feb;33(2):703-10 [1967651] J Pharmacol Exp Ther. 1990 Apr;253(1):104-12 [2329498] Pharmacol Biochem Behav. 1990 May;36(1):105-9 [2140899] Synapse. 1990;6(1):33-44 [2144664] J Pharmacol Exp Ther. 1990 Nov;255(2):478-83 [1978728] Eur J Pharmacol. 1990 Nov 6;190(1-2):51-7 [2076760] Eur J Pharmacol. 1990 Nov 20;191(1):1-10 [1982656] Eur J Pharmacol. 1991 Jul 23;200(1):9-16 [1685125] Brain Res. 1992 Jul 10;585(1-2):421-4 [1511330] Eur J Pharmacol. 1992 May 14;215(2-3):153-60 [1356787] Eur J Pharmacol. 1993 Mar 16;233(1):71-7 [7682511] Mol Pharmacol. 1993 Dec;44(6):1227-31 [7903417] Neuropharmacology. 1993 Dec;32(12):1381-6 [8152528] Neuron. 1994 Apr;12(4):845-59 [8161456] Neurotoxicology. 1998 Jun;19(3):427-41 [9621349] Neuropsychopharmacology. 1999 Mar;20(3):287-96 [10063489] Circulation. 1999 Aug 24;100(8):869-75 [10458725] J Neurochem. 2008 Jun;105(5):1770-80 [18248615] Expert Opin Drug Saf. 2009 May;8(3):317-29 [19505264] Biol Chem. 2011 Jan;392(1-2):103-15 [21194370] Neuron. 2011 Feb 24;69(4):628-49 [21338876] J Biol Chem. 2012 Jan 2;287(1):438-45 [22072712] Neuropsychopharmacology. 2012 Apr;37(5):1192-203 [22169943] J Biol Chem. 2012 May 25;287(22):18524-34 [22451652] ACS Chem Neurosci. 2013 Jan 16;4(1):182-90 [23336057] Neuropsychopharmacology. 2013 Mar;38(4):552-62 [23072836] Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16046-51 [15520385] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/npp.2013.331 ER - TY - JOUR T1 - Introduction to tobacco control supplement. AN - 1516723470; 24732156 AB - Electronic cigarettes (e-cigarettes) have recently gained significant attention in the marketplace and in the media. However, limited information is available about the worldwide impact of e-cigarettes; most public health officials are calling for more data so they can more fully understand the potential risks and benefits of e-cigarettes in order to inform regulatory action. In the USA, e-cigarettes that are marketed as tobacco products are not currently regulated by the Food and Drug Administration (FDA). However, having a continuum of nicotine-containing products that cross jurisdictional lines within the FDA in the future would create the potential (and the need) for a comprehensive nicotine strategy at the FDA. As part of developing the most appropriate approach to e-cigarette regulation, FDA Center for Tobacco Products scientists have been reviewing the available literature to determine the state of e-cigarette knowledge and have identified research areas that could be addressed. This supplement provides a summary of the current knowledge and research gaps pertaining to e-cigarettes with regards to product design, chemistry and toxicology of e-liquid and aerosol constituents, human factor-based risk factors, abuse liability, clinical pharmacology and human health effects, paediatric issues, and environmental issues. JF - Tobacco control AU - Chen, Ii-Lun AU - Husten, Corinne G AD - Center for Tobacco Products, Food and Drug Administration, , Rockville, Maryland, USA. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - ii1 EP - ii3 VL - 23 Suppl 2 KW - Index Medicus KW - Harm Reduction KW - Non-cigarette tobacco products KW - Electronic nicotine delivery devices KW - United States KW - United States Food and Drug Administration KW - Humans KW - Smoking Cessation -- methods KW - Smoking Cessation -- legislation & jurisprudence KW - Electronic Cigarettes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516723470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+control&rft.atitle=Introduction+to+tobacco+control+supplement.&rft.au=Chen%2C+Ii-Lun%3BHusten%2C+Corinne+G&rft.aulast=Chen&rft.aufirst=Ii-Lun&rft.date=2014-05-01&rft.volume=23+Suppl+2&rft.issue=&rft.spage=ii1&rft.isbn=&rft.btitle=&rft.title=Tobacco+control&rft.issn=1468-3318&rft_id=info:doi/10.1136%2Ftobaccocontrol-2013-051504 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-15 N1 - Date created - 2014-04-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: World Health Organ Tech Rep Ser. 2009;(955):1-41, back cover [20942227] Tob Control. 2014 Sep;23(5):375-84 [24259045] Lancet Oncol. 2013 Oct;14(11):1027 [24079859] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/tobaccocontrol-2013-051504 ER - TY - JOUR T1 - Electronic cigarettes in the USA: a summary of available toxicology data and suggestions for the future. AN - 1516723289; 24732158 AB - To review the available evidence evaluating the toxicological profiles of electronic cigarettes (e-cigarettes) in order to understand the potential impact of e-cigarettes on individual users and the public health. Systematic literature searches were conducted between October 2012 and October 2013 using five electronic databases. Search terms such as 'e-cigarettes' and 'electronic delivery devices' were used to identify the toxicology information for e-cigarettes. As of October 2013, the scientific literature contains very limited information regarding the toxicity of e-cigarettes commercially available in the USA. While some preliminary toxicology data suggests that e-cigarette users are exposed to lower levels of toxicants relative to cigarette smokers, the data available is extremely limited at this time. At present, there is insufficient toxicological data available to perform thorough risk assessment analyses for e-cigarettes; few toxicology studies evaluating e-cigarettes have been conducted to date, and standard toxicological testing paradigms have not been developed for comparing disparate types of tobacco products such as e-cigarettes and traditional cigarettes. Overall, the limited toxicology data on e-cigarettes in the public domain is insufficient to allow a thorough toxicological evaluation of this new type of tobacco product. In the future, the acquisition of scientific datasets that are derived from scientifically robust standard testing paradigms, include comprehensive chemical characterisation of the aerosol, provide information on users' toxicant exposure levels, and from studies replicated by independent researchers will improve the scientific community's ability to perform robust toxicological evaluations of e-cigarettes. JF - Tobacco control AU - Orr, Michael S AD - US Food and Drug Administration, Toxicology and Environmental Science Branch, Office of Science, Center for Tobacco Products, , Rockville, Maryland, USA. Y1 - 2014/05// PY - 2014 DA - May 2014 SP - ii18 EP - ii22 VL - 23 Suppl 2 KW - Aerosols KW - 0 KW - Ethylene Glycols KW - Nitrosamines KW - diethylene glycol KW - 61BR964293 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Non-cigarette tobacco products KW - Toxicology KW - Electronic nicotine delivery devices KW - United States KW - Animals KW - Humans KW - Nicotine -- analysis KW - Ethylene Glycols -- analysis KW - Nitrosamines -- analysis KW - Risk Assessment KW - Electronic Cigarettes -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516723289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+control&rft.atitle=Electronic+cigarettes+in+the+USA%3A+a+summary+of+available+toxicology+data+and+suggestions+for+the+future.&rft.au=Orr%2C+Michael+S&rft.aulast=Orr&rft.aufirst=Michael&rft.date=2014-05-01&rft.volume=23+Suppl+2&rft.issue=&rft.spage=ii18&rft.isbn=&rft.btitle=&rft.title=Tobacco+control&rft.issn=1468-3318&rft_id=info:doi/10.1136%2Ftobaccocontrol-2013-051474 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-15 N1 - Date created - 2014-04-15 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Nicotine Tob Res. 2006 Apr;8(2):309-13 [16766423] Reprod Toxicol. 2012 Dec;34(4):529-37 [22989551] Tob Control. 2014 Mar;23(2):133-9 [23467656] Inhal Toxicol. 2013 May;25(6):354-61 [23742112] Int J Environ Res Public Health. 2013 Oct;10(10):5146-62 [24135821] Crit Rev Toxicol. 2013 Apr;43(4):363-90 [23656560] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1136/tobaccocontrol-2013-051474 ER - TY - RPRT T1 - Indoor Firing Ranges and Elevated Blood Lead Levels - United States, 2002-2013 AN - 1522800056; 24759656 AB - Indoor firing ranges are a source of lead exposure and elevated blood lead levels (BLLs) among employees, their families, and customers, despite public health outreach efforts and comprehensive guidelines for controlling occupational lead exposure. There are approximately 16,000-18,000 indoor firing ranges in the United States, with tens of thousands of employees. Approximately 1 million law enforcement officers train on indoor ranges. Beaucham et al examine the data on elevated BLLs from the Adult Blood Lead Epidemiology and Surveillance program managed by CDC's National Institute for Occupational Safety and Health to estimate how many adults had elevated BLLs as a result of exposure to lead from shooting firearms. JF - MMWR. Morbidity and Mortality Weekly Report AU - Beaucham, Catherine, MPH AU - Page, Elena, MD AU - Alarcon, Walter A, MD AU - Calvert, Geoffrey M, MD AU - Methner, Mark, PhD AU - Schoonover, Todd M, PhD Y1 - 2014/04/25/ PY - 2014 DA - 2014 Apr 25 SP - 347 EP - 51 CY - Atlanta PB - U.S. Center for Disease Control KW - Public Health And Safety KW - Lead KW - Firing ranges KW - Human exposure KW - Adults KW - Occupational hazards KW - United States--US KW - Humans KW - Adult KW - Occupational Exposure -- adverse effects KW - United States -- epidemiology KW - Air Pollution, Indoor -- adverse effects KW - Firearms KW - Occupational Diseases -- epidemiology KW - Lead Poisoning -- epidemiology KW - Environmental Exposure -- adverse effects KW - Lead -- blood KW - Population Surveillance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1522800056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.atitle=Indoor+Firing+Ranges+and+Elevated+Blood+Lead+Levels+-+United+States%2C+2002-2013&rft.au=Beaucham%2C+Catherine%2C+MPH%3BPage%2C+Elena%2C+MD%3BAlarcon%2C+Walter+A%2C+MD%3BCalvert%2C+Geoffrey+M%2C+MD%3BMethner%2C+Mark%2C+PhD%3BSchoonover%2C+Todd+M%2C+PhD&rft.aulast=Beaucham&rft.aufirst=Catherine&rft.date=2014-04-25&rft.volume=63&rft.issue=16&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.issn=01492195&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Center for Disease Control Apr 25, 2014 N1 - Document feature - Tables; References N1 - Last updated - 2014-06-03 ER - TY - JOUR T1 - The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. AN - 1519257557; 23708667 AB - Many tumor suppressor genes (TSGs) are silenced through synergistic layers of epigenetic regulation including abnormal DNA hypermethylation of promoter CpG islands, repressive chromatin modifications and enhanced nucleosome deposition over transcription start sites. The protein complexes responsible for silencing of many of such TSGs remain to be identified. Our previous work demonstrated that multiple silenced TSGs in colorectal cancer cells can be partially reactivated by DNA demethylation in cells disrupted for the DNA methyltransferases 1 and 3B (DNMT1 and 3B) or by DNMT inhibitors (DNMTi). Herein, we used proteomic and functional genetic approaches to identify additional proteins that cooperate with DNMTs in silencing these key silenced TSGs in colon cancer cells. We discovered that DNMTs and the core components of the NuRD (Mi-2/nucleosome remodeling and deacetylase) nucleosome remodeling complex, chromo domain helicase DNA-binding protein 4 (CHD4) and histone deacetylase 1 (HDAC1) occupy the promoters of several of these hypermethylated TSGs and physically and functionally interact to maintain their silencing. Consistent with this, we find an inverse relationship between expression of HDAC1 and 2 and these TSGs in a large panel of primary colorectal tumors. We demonstrate that DNMTs and NuRD cooperate to maintain the silencing of several negative regulators of the WNT and other signaling pathways. We find that depletion of CHD4 is synergistic with DNMT inhibition in reducing the viability of colon cancer cells in correlation with reactivation of TSGs, suggesting that their combined inhibition may be beneficial for the treatment of colon cancer. Since CHD4 has ATPase activity, our data identify CHD4 as a potentially novel drug target in cancer. JF - Oncogene AU - Cai, Y AU - Geutjes, E-J AU - de Lint, K AU - Roepman, P AU - Bruurs, L AU - Yu, L-R AU - Wang, W AU - van Blijswijk, J AU - Mohammad, H AU - de Rink, I AU - Bernards, R AU - Baylin, S B AD - Department of Oncology and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD, USA. ; Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Amsterdam, The Netherlands. ; Department of Research and Development, Agendia NV, Amsterdam, The Netherlands. ; Division of Systems Biology, Center of Excellence for Proteomics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA. ; Central Microarray and Deep Sequencing Core Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Y1 - 2014/04/24/ PY - 2014 DA - 2014 Apr 24 SP - 2157 EP - 2168 VL - 33 IS - 17 KW - Autoantigens KW - 0 KW - CHD4 protein, human KW - Wnt Proteins KW - decitabine KW - 776B62CQ27 KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - HDAC1 protein, human KW - EC 3.5.1.98 KW - HDAC2 protein, human KW - Histone Deacetylase 1 KW - Histone Deacetylase 2 KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Wnt Proteins -- metabolism KW - Promoter Regions, Genetic KW - Gene Knockdown Techniques KW - Azacitidine -- pharmacology KW - Apoptosis KW - Genes, Tumor Suppressor KW - Humans KW - Azacitidine -- analogs & derivatives KW - Gene Expression KW - HCT116 Cells KW - Epigenesis, Genetic KW - Protein Binding KW - Colorectal Neoplasms KW - Gene Expression Regulation, Neoplastic KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex -- metabolism KW - Mi-2 Nucleosome Remodeling and Deacetylase Complex -- genetics KW - Histone Deacetylase 1 -- genetics KW - Histone Deacetylase 1 -- metabolism KW - Histone Deacetylase 2 -- genetics KW - DNA (Cytosine-5-)-Methyltransferase -- antagonists & inhibitors KW - Autoantigens -- genetics KW - DNA (Cytosine-5-)-Methyltransferase -- metabolism KW - Autoantigens -- metabolism KW - Histone Deacetylase 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1519257557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=The+NuRD+complex+cooperates+with+DNMTs+to+maintain+silencing+of+key+colorectal+tumor+suppressor+genes.&rft.au=Cai%2C+Y%3BGeutjes%2C+E-J%3Bde+Lint%2C+K%3BRoepman%2C+P%3BBruurs%2C+L%3BYu%2C+L-R%3BWang%2C+W%3Bvan+Blijswijk%2C+J%3BMohammad%2C+H%3Bde+Rink%2C+I%3BBernards%2C+R%3BBaylin%2C+S+B&rft.aulast=Cai&rft.aufirst=Y&rft.date=2014-04-24&rft.volume=33&rft.issue=17&rft.spage=2157&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=1476-5594&rft_id=info:doi/10.1038%2Fonc.2013.178 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-06-10 N1 - Date created - 2014-04-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11797-801 [7527544] Nat Genet. 2004 Apr;36(4):417-22 [15034581] Nature. 1998 May 28;393(6683):386-9 [9620804] Nat Genet. 1999 Jan;21(1):103-7 [9916800] Genes Dev. 1999 Aug 1;13(15):1924-35 [10444591] Nat Genet. 1999 Sep;23(1):62-6 [10471500] Oncogene. 2005 Jan 6;24(1):13-9 [15637587] Nat Rev Cancer. 2005 Sep;5(9):689-98 [16110319] Nature. 2006 Feb 16;439(7078):871-4 [16357870] Genes Dev. 2006 Nov 15;20(22):3089-103 [17085482] Genes Dev. 2006 Dec 1;20(23):3215-31 [17158741] Oncogene. 2007 Jan 4;26(1):77-90 [16799634] Cell. 2007 Feb 23;128(4):683-92 [17320506] Cell. 2007 Feb 23;128(4):693-705 [17320507] PLoS Genet. 2007 Sep;3(9):1709-23 [17892325] J Proteome Res. 2007 Nov;6(11):4150-62 [17924679] Cancer Cell. 2007 Nov;12(5):432-44 [17996647] Mol Cell Biol. 2008 Jan;28(1):215-26 [17967891] Br J Cancer. 2008 Jan 29;98(2):466-73 [18087279] Clin Cancer Res. 2008 Mar 15;14(6):1669-77 [18347167] Mol Cell Biol. 2008 Oct;28(19):5912-23 [18644863] Mol Cell Biol. 2008 Oct;28(19):6094-103 [18644872] Nat Rev Drug Discov. 2008 Oct;7(10):854-68 [18827828] J Exp Biol. 2009 Feb;212(Pt 3):341-6 [19151208] Cancer Lett. 2009 Aug 8;280(2):168-76 [19103471] Cancer Res. 2009 Aug 1;69(15):6322-30 [19602592] Epigenetics. 2009 Jul 1;4(5):307-12 [19633433] J Clin Oncol. 2009 Nov 10;27(32):5410-7 [19826128] Clin Cancer Res. 2009 Dec 1;15(23):7217-28 [19934284] J Am Chem Soc. 2010 Feb 17;132(6):1782-3 [20095602] Nature. 2010 Jul 15;466(7304):388-92 [20512117] EMBO J. 2010 Aug 4;29(15):2586-97 [20571512] J Cell Biol. 2010 Sep 6;190(5):741-9 [20805320] J Cell Biol. 2010 Sep 6;190(5):731-40 [20805324] EMBO J. 2010 Sep 15;29(18):3130-9 [20693977] Nat Biotechnol. 2010 Oct;28(10):1057-68 [20944598] J Clin Oncol. 2011 Jan 1;29(1):17-24 [21098318] EMBO J. 2011 Jan 19;30(2):249-62 [21131905] Cell Cycle. 2011 Feb 1;10(3):406-12 [21270520] Nat Rev Cancer. 2011 Aug;11(8):588-96 [21734722] Nucleic Acids Res. 2012 May;40(10):4334-46 [22278882] Bioinformatics. 2009 May 1;25(9):1105-11 [19289445] Nat Cell Biol. 2002 Jan;4(1):20-5 [11780127] Genes Dev. 2002 Jan 1;16(1):6-21 [11782440] Science. 2002 Feb 8;295(5557):1079-82 [11834837] Nature. 2002 Apr 4;416(6880):552-6 [11932749] Nat Genet. 2002 Jun;31(2):141-9 [11992124] Science. 2002 Nov 29;298(5599):1747-52 [12399542] Nat Genet. 2003 Jun;34(2):145-7 [12730693] Nat Genet. 2003 Jun;34(2):187-92 [12740577] Science. 1997 Sep 26;277(5334):1996-2000 [9302295] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/onc.2013.178 ER - TY - JOUR T1 - Systematic Review and Evidence Integration for Literature-Based Environmental Health Science Assessments AN - 1551644857; 20395149 AB - Background: Systematic-review methodologies provide objectivity and transparency to the process of collecting and synthesizing scientific evidence in reaching conclusions on specific research questions. There is increasing interest in applying these procedures to address environmental health questions. Objectives: The goal was to develop a systematic-review framework to address environmental health questions by extending approaches developed for clinical medicine to handle the breadth of data relevant to environmental health sciences (e.g., human, animal, and mechanistic studies). Methods: The Office of Health Assessment and Translation (OHAT) adapted guidance from authorities on systematic-review and sought advice during development of the OHAT Approach through consultation with technical experts in systematic review and human health assessments, as well as scientific advisory groups and the public. The method was refined by considering expert and public comments and through application to case studies. Results and Discussion: Here we present a seven-step framework for systematic review and evidence integration for reaching hazard identification conclusions: 1) problem formulation and protocol development, 2) search for and select studies for inclusion, 3) extract data from studies, 4) assess the quality or risk of bias of individual studies, 5) rate the confidence in the body of evidence, 6) translate the confidence ratings into levels of evidence, and 7) integrate the information from different evidence streams (human, animal, and "other relevant data" including mechanistic or in vitro studies) to develop hazard identification conclusions. Conclusion: The principles of systematic review can be successfully applied to environmental health questions to provide greater objectivity and transparency to the process of developing conclusions. Citation: Rooney AA, Boyles AL, Wolfe MS, Bucher JR, Thayer KA. 2014. Systematic review and evidence integration for literature-based environmental health science assessments. Environ Health Perspect 122:711-718; http://dx.doi.org/10.1289/ehp.1307972 JF - Environmental Health Perspectives AU - Rooney, Andrew A AU - Boyles, Abee L AU - Wolfe, Mary S AU - Bucher, John R AU - Thayer, Kristina A AD - Office of Health Assessment and Translation, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2014/04/22/ PY - 2014 DA - 2014 Apr 22 SP - 711 EP - 718 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 122 IS - 7 SN - 0091-6765, 0091-6765 KW - Risk Abstracts; Environment Abstracts; Health & Safety Science Abstracts KW - Transparency KW - Risk assessment KW - Case studies KW - Reviews KW - Environmental health KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - R2 23060:Medical and environmental health KW - ENA 07:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1551644857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Systematic+Review+and+Evidence+Integration+for+Literature-Based+Environmental+Health+Science+Assessments&rft.au=Rooney%2C+Andrew+A%3BBoyles%2C+Abee+L%3BWolfe%2C+Mary+S%3BBucher%2C+John+R%3BThayer%2C+Kristina+A&rft.aulast=Rooney&rft.aufirst=Andrew&rft.date=2014-04-22&rft.volume=122&rft.issue=7&rft.spage=711&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1307972 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-08-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Risk assessment; Transparency; Case studies; Reviews; Environmental health DO - http://dx.doi.org/10.1289/ehp.1307972 ER - TY - JOUR T1 - High fat diet and GLP-1 drugs induce pancreatic injury in mice. AN - 1514435284; 24534256 AB - Glucagon Like Peptide-1 (GLP-1) drugs are currently used to treat type-2 diabetes. Safety concerns for increased risk of pancreatitis and pancreatic ductal metaplasia have accompanied these drugs. High fat diet (HFD) is a type-2 diabetes risk factor that may affect the response to GLP-1 drug treatment. The objective of the present study was to investigate the effects of diet and GLP-1 based drugs on the exocrine pancreas in mice. Experiments were designed in a mouse model of insulin resistance created by feeding a HFD or standard diet (STD) for 6weeks. The GLP-1 drugs, sitagliptin (SIT) and exenatide (EXE) were administered once daily for additional 6weeks in both mice fed HFD or STD. The results showed that body weight, blood glucose levels, and serum levels of pro-inflammatory cytokines (TNFα, IL-1β, and KC) were significantly greater in HFD mice than in STD mice regardless of GLP-1 drug treatment. The semi-quantitative grading showed that pancreatic changes were significantly greater in EXE and SIT-treated mice compared to control and that HFD exacerbated spontaneous exocrine pancreatic changes seen in saline-treated mice on a standard diet. Exocrine pancreatic changes identified in this study included acinar cell injury (hypertrophy, autophagy, apoptosis, necrosis, and atrophy), vascular injury, interstitial edema and inflammation, fat necrosis, and duct changes. These findings support HFD as a risk factor to increased susceptibility/severity for acute pancreatitis and indicate that GLP-1 drugs cause pancreatic injury that can be exacerbated in a HFD environment. Published by Elsevier Inc. JF - Toxicology and applied pharmacology AU - Rouse, Rodney AU - Xu, Lin AU - Stewart, Sharron AU - Zhang, Jun AD - Division of Applied Regulatory Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA. Electronic address: rodney.rouse@fda.hhs.gov. ; Division of Applied Regulatory Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD 20993, USA. Y1 - 2014/04/15/ PY - 2014 DA - 2014 Apr 15 SP - 104 EP - 114 VL - 276 IS - 2 KW - Glp1r protein, mouse KW - 0 KW - Glucagon-Like Peptide-1 Receptor KW - Hypoglycemic Agents KW - Peptides KW - Pyrazines KW - Receptors, Glucagon KW - Triazoles KW - Venoms KW - exenatide KW - 9P1872D4OL KW - Sitagliptin Phosphate KW - TS63EW8X6F KW - Index Medicus KW - Macrophage activation KW - Pancreatic vasculitis KW - Acinar cell death KW - High fat diet KW - Pro-inflammatory cytokines KW - Drug-induced pancreatitis KW - Acute Disease KW - Animals KW - Necrosis KW - Apoptosis -- drug effects KW - Mice, Inbred C57BL KW - Mice KW - Atrophy KW - Pancreatitis -- etiology KW - Male KW - Pyrazines -- toxicity KW - Pancreas -- pathology KW - Receptors, Glucagon -- agonists KW - Diet, High-Fat -- adverse effects KW - Triazoles -- toxicity KW - Hypoglycemic Agents -- toxicity KW - Venoms -- toxicity KW - Pancreas -- drug effects KW - Peptides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1514435284?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=High+fat+diet+and+GLP-1+drugs+induce+pancreatic+injury+in+mice.&rft.au=Rouse%2C+Rodney%3BXu%2C+Lin%3BStewart%2C+Sharron%3BZhang%2C+Jun&rft.aulast=Rouse&rft.aufirst=Rodney&rft.date=2014-04-15&rft.volume=276&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=1096-0333&rft_id=info:doi/10.1016%2Fj.taap.2014.01.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-05-30 N1 - Date created - 2014-04-07 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.taap.2014.01.021 ER - TY - CPAPER T1 - Moving forward in the companion diagnostic paradigm: Regulatory considerations T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541355183; 6287840 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Mansfield, Elizabeth Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Oncology KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541355183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Moving+forward+in+the+companion+diagnostic+paradigm%3A+Regulatory+considerations&rft.au=Mansfield%2C+Elizabeth&rft.aulast=Mansfield&rft.aufirst=Elizabeth&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - The Tobacco Control Act and public health regulatory framework T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541355165; 6287283 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Dresler, Carolyn Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Tobacco KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541355165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Organizational+Change+Management&rft.atitle=Balanced+or+unbalanced+routines%3A+the+case+of+two+routines+dynamics+in+a+French+hospital&rft.au=Habib%2C+Johanna%3BKrohmer%2C+Cathy&rft.aulast=Habib&rft.aufirst=Johanna&rft.date=2016-05-20&rft.volume=29&rft.issue=4&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Journal+of+Organizational+Change+Management&rft.issn=09534814&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Safety reporting requirements for an IND T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541355139; 6287281 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Le, Robert Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541355139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Safety+reporting+requirements+for+an+IND&rft.au=Le%2C+Robert&rft.aulast=Le&rft.aufirst=Robert&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Careers in Cancer: Government T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541355126; 6287855 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Lyn-Cook, Beverly AU - Rodriguez, Luz Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Careers KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541355126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Careers+in+Cancer%3A+Government&rft.au=Lyn-Cook%2C+Beverly%3BRodriguez%2C+Luz&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Design of early-phase clinical trials of cellular and gene therapy products T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354929; 6287282 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Bross, Peter Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Gene therapy KW - Clinical trials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Design+of+early-phase+clinical+trials+of+cellular+and+gene+therapy+products&rft.au=Bross%2C+Peter&rft.aulast=Bross&rft.aufirst=Peter&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Currently available regulatory guidances T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354855; 6287664 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Theoret, Marc Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Oncology KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Currently+available+regulatory+guidances&rft.au=Theoret%2C+Marc&rft.aulast=Theoret&rft.aufirst=Marc&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Biomarkers assays and drug trials: What cancer researchers should know about FDA regulation T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354822; 6287340 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Litwack, David Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Bioindicators KW - FDA KW - Biomarkers KW - biomarkers KW - Drugs KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Biomarkers+assays+and+drug+trials%3A+What+cancer+researchers+should+know+about+FDA+regulation&rft.au=Litwack%2C+David&rft.aulast=Litwack&rft.aufirst=David&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - CTP research program and priorities T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354802; 6287284 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Backinger, Cathy Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Priorities KW - CTP KW - Research programs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=CTP+research+program+and+priorities&rft.au=Backinger%2C+Cathy&rft.aulast=Backinger&rft.aufirst=Cathy&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Codevelopment of a diagnostic with a therapeutic T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354672; 6287341 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Bradley, Pamela Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Oncology KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Codevelopment+of+a+diagnostic+with+a+therapeutic&rft.au=Bradley%2C+Pamela&rft.aulast=Bradley&rft.aufirst=Pamela&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Careers in Government T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354637; 6287598 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Lyn-Cook, Beverly Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Careers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354637?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Careers+in+Government&rft.au=Lyn-Cook%2C+Beverly&rft.aulast=Lyn-Cook&rft.aufirst=Beverly&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - The Population Assessment of Tobacco and Health (PATH) Study T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354575; 6287286 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Borek, Nicolette Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Tobacco UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=The+Population+Assessment+of+Tobacco+and+Health+%28PATH%29+Study&rft.au=Borek%2C+Nicolette&rft.aulast=Borek&rft.aufirst=Nicolette&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Use of biopsies for clinical and regulatory decision making in late-stage drug development T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354555; 6287736 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Prowell, Tatiana Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Decision making KW - Biopsy KW - Drug development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Use+of+biopsies+for+clinical+and+regulatory+decision+making+in+late-stage+drug+development&rft.au=Prowell%2C+Tatiana&rft.aulast=Prowell&rft.aufirst=Tatiana&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Regulator's perspective on expedited approval pathways T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354515; 6287819 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Kluetz, Paul Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Oncology KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Regulator%27s+perspective+on+expedited+approval+pathways&rft.au=Kluetz%2C+Paul&rft.aulast=Kluetz&rft.aufirst=Paul&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - The role of product regulation: FDA actions under the Family Smoking Prevention and Tobacco Control Act T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354374; 6287673 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Zeller, Mitchell Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Smoking KW - Prevention KW - FDA KW - Tobacco UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=The+role+of+product+regulation%3A+FDA+actions+under+the+Family+Smoking+Prevention+and+Tobacco+Control+Act&rft.au=Zeller%2C+Mitchell&rft.aulast=Zeller&rft.aufirst=Mitchell&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - The Tobacco Centers of Regulatory Science and funding opportunities T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354253; 6287285 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Van Bemmel, Dana Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Financing KW - Tobacco UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=The+Tobacco+Centers+of+Regulatory+Science+and+funding+opportunities&rft.au=Van+Bemmel%2C+Dana&rft.aulast=Van+Bemmel&rft.aufirst=Dana&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Establishing optimal regulatory pathways for efficient approval of analytical and clinically validated tests T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354120; 6288033 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Mansfield, Elizabeth Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Oncology KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Establishing+optimal+regulatory+pathways+for+efficient+approval+of+analytical+and+clinically+validated+tests&rft.au=Mansfield%2C+Elizabeth&rft.aulast=Mansfield&rft.aufirst=Elizabeth&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Regulatory considerations for biomarker and diagnostic test requirements in exploratory and registration studies T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354021; 6287959 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Mansfield, Elizabeth Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Bioindicators KW - Biomarkers KW - biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Regulatory+considerations+for+biomarker+and+diagnostic+test+requirements+in+exploratory+and+registration+studies&rft.au=Mansfield%2C+Elizabeth&rft.aulast=Mansfield&rft.aufirst=Elizabeth&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Clinical implications of screening tests for patient accrual into trials and directing patient care T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541354001; 6288031 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Kim, Geoffrey Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Screening KW - Clinical trials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541354001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Clinical+implications+of+screening+tests+for+patient+accrual+into+trials+and+directing+patient+care&rft.au=Kim%2C+Geoffrey&rft.aulast=Kim&rft.aufirst=Geoffrey&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - FDA perspective on innovative trial designs to accelerate availability of highly effective anticancer therapies T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541353572; 6287960 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Blumenthal, Gideon Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Therapy KW - FDA KW - Innovations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541353572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=FDA+perspective+on+innovative+trial+designs+to+accelerate+availability+of+highly+effective+anticancer+therapies&rft.au=Blumenthal%2C+Gideon&rft.aulast=Blumenthal&rft.aufirst=Gideon&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - CPAPER T1 - Pitfalls in oncology drug development: A regulator's view T2 - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AN - 1541353294; 6288127 JF - 105th Annual Meeting of the American Association for Cancer Research (AACR 2014) AU - Prowell, Tatiana Y1 - 2014/04/05/ PY - 2014 DA - 2014 Apr 05 KW - Oncology KW - Drug development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541353294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.atitle=Pitfalls+in+oncology+drug+development%3A+A+regulator%27s+view&rft.au=Prowell%2C+Tatiana&rft.aulast=Prowell&rft.aufirst=Tatiana&rft.date=2014-04-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=105th+Annual+Meeting+of+the+American+Association+for+Cancer+Research+%28AACR+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/aacr-annual-meeting-2014/program.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-27 N1 - Last updated - 2014-06-30 ER - TY - RPRT T1 - Strategic Plan for Autism Spectrum Disorder Research: 2013 Update AN - 1773215498; ED562027 AB - The Combating Autism Act (CAA; Public Law 109-416) and the subsequent Combating Autism Reauthorization Act (CARA; Public Law 112-32) established an Interagency Autism Coordinating Committee (IACC) to advise the Secretary of Health and Human Services on issues related to Autism Spectrum Disorder (ASD). One responsibility of the IACC is the development of a strategic plan for ASD research, to be updated yearly. The IACC Strategic Plan, first issued in 2009, was produced by the IACC, composed of federal officials and public stakeholders, with extensive input from researchers, adults on the autism spectrum, parents, advocates, and the general public that was gathered through a series of meetings and public comment opportunities. This inclusive process ensured that the IACC Strategic Plan reflected diverse perspectives from across the autism community. The IACC Strategic Plan is organized around seven general topic areas that are represented in the plan as consumer-focused Questions (e.g., Question 1, "When should I be concerned?" which covers the topic of screening and diagnosis). Each Question is assigned a chapter that provides a description of the state of the science in that area. Each chapter also contains a section describing the research and community needs for its relevant Question; the aspirational goal, or long term vision, for each area; and a list of specific long- and short-term objectives. The objectives were created by the Committee to address critical gaps and opportunities they perceived in the research landscape in 2009. Each objective also includes a recommended budget that serves as an estimate of how much the Committee projects it might cost to conduct the research-related activities described. Each section contains a list of references. The IACC Strategic Plan was updated in 2010 and 2011, adding several new objectives over these years. In 2012, following the reauthorization of the Committee, the plan was updated with advances and new research opportunities. For the 2013 update of the IACC Strategic Plan, the Committee voted to focus on accountability without adding new objectives or re-writing the previous version. With access to an extensive portfolio analysis conducted by the National Institutes of Health (NIH) Office for Autism Research Coordination (OARC) linked to every objective, as well as the annual IACC Summary of Advances documents from past years, the IACC reviewed what has been invested in ASD research in the United States since 2008. Using data from both public and private funders, the IACC determined the level of progress for each of the 78 objectives in terms of the number of projects funded and dollars committed to each objective since 2008. To assess the return on this investment, the IACC also invited a group of external experts to evaluate how research has supported progress toward the aspirational goals in each of the seven chapters of the IACC Strategic Plan. This update summarizes both investment and scientific progress across all seven Questions of the IACC Strategic Plan. Most areas have received extensive investment ($1.5 billion expended from 2008-2012 by federal and private funders) and significant progress has been made since the original Plan was published in January, 2009. According to the PubMed database of biomedical research literature, over 11,000 journal articles on autism have been published since January, 2009, more than double the number published in the preceding 5 years. The world of ASD research has changed profoundly during this period, with increases in United States ASD prevalence estimates, changes in ASD diagnostic criteria, greater understanding of co-occurring conditions and services needs, and new insights from genetics, environmental studies, and neuroimaging into the biology and etiology of ASD. In addition to this review of the investment and progress, the Committee and external experts identified current research gaps, needs and barriers, as well as new opportunities created by advances in the field, which can provide direction for future investment. "ASD Research Progress on IACC Strategic Plan Objectives: Summary of Years 2008 to 2012" can be found in the appendix. ["2011 Strategic Plan for Autism Spectrum Disorder Research" can be accessed in ERIC at ED524623. For "2010 Strategic Plan for Autism Spectrum Disorder Research," see ED524616.] Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 143 PB - Interagency Autism Coordinating Committee. US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Financial Support KW - At Risk Persons KW - Etiology KW - Federal Aid KW - Clinical Diagnosis KW - Pervasive Developmental Disorders KW - Intervention KW - Adults KW - Advisory Committees KW - Portfolios (Background Materials) KW - Federal Legislation KW - Access to Information KW - Guides KW - Access to Health Care KW - Research KW - Autism KW - Strategic Planning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773215498?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - RPRT T1 - 2013 Summary of Advances in Autism Spectrum Disorder Research AN - 1773215227; ED562024 AB - Each year, the Interagency Autism Coordinating Committee (IACC) releases its annual list of scientific advances that represent significant progress in the field. The 20 studies selected have given new insight into the complex causes of autism and potential risk factors, studied clues that could lead to earlier diagnosis, and evaluated promising early intervention strategies. The advances also address the prevalence of ASD both in the United States and internationally, as well as the service needs of people with ASD across the lifespan. The "2013 Summary of Advances" provides short, plain language synopses of the top research breakthroughs selected by the IACC from a pool of peer-reviewed articles nominated by the members. Articles are grouped according to the questions of the "IACC Strategic Plan for ASD Research." Citations for the articles selected for the "Summary of Advances," as well as a complete listing of those nominated, are included at the end of the document. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 52 PB - Interagency Autism Coordinating Committee. US Department of Health and Human Services, 200 Independence Avenue SW, Washington, DC 20201. KW - ERIC, Resources in Education (RIE) KW - Clinical Diagnosis KW - Pervasive Developmental Disorders KW - Adults KW - Supported Employment KW - Comorbidity KW - Hispanic Americans KW - Neurological Organization KW - Cost Effectiveness KW - Child Development KW - Research KW - Journal Articles KW - At Risk Persons KW - Etiology KW - Eye Movements KW - Pediatrics KW - Mothers KW - Brain KW - Developmental Delays KW - Behavior Problems KW - Screening Tests KW - Cognitive Ability KW - Prevention KW - Foreign Countries KW - Urban Areas KW - Early Intervention KW - Incidence KW - Autism KW - Physical Health KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773215227?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Encephalitis-Associated Hospitalizations among American Indians and Alaska Natives AN - 1717496250; PQ0002006821 AB - Encephalitis produces considerable morbidity in the United States, but morbidity rates among American Indian/Alaska Native (Al/AN) people have not been described. Hospitalization records listing an encephalitis diagnosis were analyzed by using Indian Health Service direct/contract inpatient data. For 1998-2010, there were 436 encephalitis-associated hospitalizations among Al/AN people, an average annual age-adjusted hospitalization rate of 3.1/100,000 population. The rate for infants (11.9) was more than double that for any other age group. Death occurred for 4.1% of hospitalizations. Consistent with reports for the general U.S. population, the rate was high among infants and most (53.9%) hospitalizations were of unexplained etiology. The average annual rate during the study period appeared lower than for the general U.S. population, due particularly to lower rates in the elderly. Future community-based surveillance and mortality studies are needed to confirm these findings and examine reasons underlying the low rates of encephalitis in AI/AN people. JF - American Journal of Tropical Medicine and Hygiene AU - Mehal, Jason M AU - Holman, Robert C AU - Vora, Neil M AU - Blanton, Jesse AU - Gordon, Paul H AU - Cheek, James E AD - Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, and Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia; Public Health Program, Department of Family and Community Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico; Northern Navajo Medical Center, Indian Health Service, Shiprock, New Mexico, jmehal@cdc.gov Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 755 EP - 759 PB - American Society of Tropical Medicine and Hygiene, 60 Revere Drive, Suite 500 Northbrook IL 60062 United States VL - 90 IS - 4 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - Mortality KW - Etiology KW - Age KW - Data processing KW - Contracts KW - Surveillance and enforcement KW - INE, USA, Alaska KW - Encephalitis KW - Morbidity KW - Aetiology KW - Population genetics KW - Geriatrics KW - Age groups KW - Hygiene KW - Mortality causes KW - Infants KW - K 03400:Human Diseases KW - Q5 08504:Effects on organisms KW - J 02400:Human Diseases KW - Q1 08604:Stock assessment and management KW - N3 11150:General and miscellaneous topics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1717496250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Encephalitis-Associated+Hospitalizations+among+American+Indians+and+Alaska+Natives&rft.au=Mehal%2C+Jason+M%3BHolman%2C+Robert+C%3BVora%2C+Neil+M%3BBlanton%2C+Jesse%3BGordon%2C+Paul+H%3BCheek%2C+James+E&rft.aulast=Mehal&rft.aufirst=Jason&rft.date=2014-04-01&rft.volume=90&rft.issue=4&rft.spage=755&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/10.4269%2Fajtmh.13-0420 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Population genetics; Contracts; Surveillance and enforcement; Age groups; Hygiene; Aetiology; Mortality causes; Mortality; Age; Etiology; Data processing; Geriatrics; Morbidity; Encephalitis; Infants; INE, USA, Alaska DO - http://dx.doi.org/10.4269/ajtmh.13-0420 ER - TY - JOUR T1 - Human metabolic correlates of body mass index AN - 1709172176; 19348156 AB - A high body mass index (BMI) is a major risk factor for several chronic diseases, but the biology underlying these associations is not well-understood. Dyslipidemia, inflammation, and elevated levels of growth factors and sex steroid hormones explain some of the increased disease risk, but other metabolic factors not yet identified may also play a role. In order to discover novel metabolic biomarkers of BMI, we used non-targeted metabolomics to assay 317 metabolites in blood samples from 947 participants and examined the cross-sectional associations between metabolite levels and BMI. Participants were from three studies in the United States and China. Height, weight, and potential confounders were ascertained by questionnaire (US studies) or direct measurement (Chinese study). Metabolite levels were measured using liquid-phase chromatography and gas chromatography coupled with mass spectrometry. We evaluated study-specific associations using linear regression, adjusted for age, gender, and smoking, and we estimated combined associations using random effects meta-analysis. The meta-analysis revealed 37 metabolites significantly associated with BMI, including 19 lipids, 12 amino acids, and 6 others, at the Bonferroni significance threshold (P 0.05). In total, 110 metabolites were associated with BMI at the P < 0.05 level. These findings establish a baseline for the BMI metabolome, and suggest new targets for researchers attempting to clarify mechanistic links between BMI and disease risk. JF - Metabolomics AU - Moore, Steven C AU - Matthews, Charles E AU - Sampson, Joshua N AU - Stolzenberg-Solomon, Rachael Z AU - Zheng, Wei AU - Cai, Qiuyin AU - Tan, Yu Ting AU - Chow, Wong-Ho AU - Ji, Bu-Tian AU - Liu, Da Ke AU - Xiao, Qian AU - Boca, Simina M AU - Leitzmann, Michael F AU - Yang, Gong AU - Xiang, Yong Bing AU - Sinha, Rashmi AU - Shu, Xiao Ou AU - Cross, Amanda J AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, 9609 Medical Center Drive, Rockville, MD, 20850, USA, moorest@mail.nih.gov Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 259 EP - 269 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 10 IS - 2 SN - 1573-3882, 1573-3882 KW - Biotechnology and Bioengineering Abstracts KW - Inventories KW - Amino acids KW - Lipids KW - Metabolites KW - Steroid hormones KW - biomarkers KW - Mass spectroscopy KW - Inflammation KW - Smoking KW - Histidine KW - Reviews KW - Risk factors KW - Oxidation KW - Dyslipidemia KW - Fatty acids KW - Neurotransmitters KW - Body mass index KW - metabolomics KW - Sex KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709172176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolomics&rft.atitle=Human+metabolic+correlates+of+body+mass+index&rft.au=Moore%2C+Steven+C%3BMatthews%2C+Charles+E%3BSampson%2C+Joshua+N%3BStolzenberg-Solomon%2C+Rachael+Z%3BZheng%2C+Wei%3BCai%2C+Qiuyin%3BTan%2C+Yu+Ting%3BChow%2C+Wong-Ho%3BJi%2C+Bu-Tian%3BLiu%2C+Da+Ke%3BXiao%2C+Qian%3BBoca%2C+Simina+M%3BLeitzmann%2C+Michael+F%3BYang%2C+Gong%3BXiang%2C+Yong+Bing%3BSinha%2C+Rashmi%3BShu%2C+Xiao+Ou%3BCross%2C+Amanda+J&rft.aulast=Moore&rft.aufirst=Steven&rft.date=2014-04-01&rft.volume=10&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Metabolomics&rft.issn=15733882&rft_id=info:doi/10.1007%2Fs11306-013-0574-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Number of references - 41 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Inventories; Amino acids; Lipids; Metabolites; Steroid hormones; biomarkers; Mass spectroscopy; Inflammation; Smoking; Risk factors; Reviews; Histidine; Dyslipidemia; Oxidation; Fatty acids; Neurotransmitters; Body mass index; metabolomics; Sex DO - http://dx.doi.org/10.1007/s11306-013-0574-1 ER - TY - JOUR T1 - Assessing incentives for service-level selection in private health insurance exchanges AN - 1683503841 AB - Even with open enrollment and mandated purchase, incentives created by adverse selection may undermine the efficiency of service offerings by plans in the new health insurance Exchanges created by the Affordable Care Act. Using data on persons likely to participate in Exchanges drawn from five waves of the Medical Expenditure Panel Survey, we measure plan incentives in two ways. First, we construct predictive ratios, improving on current methods by taking into account the role of premiums in financing plans. Second, relying on an explicit model of plan profit maximization, we measure incentives based on the predictability and predictiveness of various medical diagnoses. Among the chronic diseases studied, plans have the greatest incentive to skimp on care for cancer, and mental health and substance abuse. JF - Journal of Health Economics AU - McGuire, Thomas G AU - Newhouse, Joseph P AU - Normand, Sharon-Lise AU - Shi, Julie AU - Zuvekas, Samuel AD - Department of Health Care Policy, Harvard Medical School, United States, NBER, United States ; Department of Health Care Policy, Harvard Medical School, United States, NBER, United States, Department of Health Policy and Management, Harvard School of Public Health, United States, The Harvard Kennedy School, United States ; Department of Health Care Policy, Harvard Medical School, United States, Department of Health Policy and Management, Harvard School of Public Health, United States ; Department of Health Care Policy, Harvard Medical School, United States ; Agency for Healthcare Research and Quality, United States ; Department of Health Care Policy, Harvard Medical School, United States; NBER, United States Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 47 EP - 63 CY - Amsterdam PB - Elsevier Science Ltd. VL - 35 SN - 0167-6296 KW - Public Health And Safety KW - Health insurance KW - Exchanges KW - Adverse selection KW - Cancer KW - Substance abuse KW - Chronic diseases KW - Enrollment KW - Expenditure KW - Financing KW - Incentives KW - Insurance KW - Mental health care KW - Premiums UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1683503841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Economics&rft.atitle=Assessing+incentives+for+service-level+selection+in+private+health+insurance+exchanges&rft.au=McGuire%2C+Thomas+G%3BNewhouse%2C+Joseph+P%3BNormand%2C+Sharon-Lise%3BShi%2C+Julie%3BZuvekas%2C+Samuel&rft.aulast=McGuire&rft.aufirst=Thomas&rft.date=2014-04-01&rft.volume=35&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Economics&rft.issn=01676296&rft_id=info:doi/10.1016%2Fj.jhealeco.2014.01.009 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-04-15 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.1016/j.jhealeco.2014.01.009 ER - TY - JOUR T1 - What are tests for? The implications of stuttering steps along the US patient pathway AN - 1639480906; 4628479 AB - This article explores the implications of how US family physicians make decisions about ordering diagnostic tests for their patients. Data is based on a study of 256 physicians interviewed after viewing a video vignette of a presenting patient. The qualitative analysis of 778 statements relating to trustworthiness of evidence for their decision making, the use of any kind of technology and diagnostic testing suggests a range of internal and external constraints on physician decision making. Test-ordering for family physicians in the United States is significantly influenced by both hidden cognitive processes related to the physician's calculation of patient resources and a health insurance system that requires certain types of evidence in order to permit further tests or particular interventions. The consequence of the need for physicians to meet multiple forms of proof that may not always relate to relevant treatment delays a diagnosis and treatment plan agreed not only by the physician and patient but also the insurance company. This results in a patient journey that is made up of stuttering steps to a confirmed diagnosis and treatment undermining patient-centred practice, compromising patient care, constraining physician autonomy and creating additional expense. All rights reserved, Elsevier JF - Social science and medicine AU - Tritter, Jonathan Q AU - Lutfey, Karen AU - Mckinlay, John AD - Aston University ; University of Colorado ; US Department of Health and Human Services Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 37 EP - 43 VL - 107 SN - 0277-9536, 0277-9536 KW - Sociology KW - Uncertainty KW - Doctors KW - Health insurance KW - U.S.A. KW - Social sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1639480906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+science+and+medicine&rft.atitle=What+are+tests+for%3F+The+implications+of+stuttering+steps+along+the+US+patient+pathway&rft.au=Tritter%2C+Jonathan+Q%3BLutfey%2C+Karen%3BMckinlay%2C+John&rft.aulast=Tritter&rft.aufirst=Jonathan&rft.date=2014-04-01&rft.volume=107&rft.issue=&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Social+science+and+medicine&rft.issn=02779536&rft_id=info:doi/10.1016%2Fj.socscimed.2014.02.012 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-12-22 N1 - Last updated - 2014-12-23 N1 - SubjectsTermNotLitGenreText - 13078; 5784 6592 4957 11923 11949 13521; 11920; 3675 10299 13682 7883 8864; 433 293 14 DO - http://dx.doi.org/10.1016/j.socscimed.2014.02.012 ER - TY - JOUR T1 - A Pathfinder Resource for Best Practices in Mental Health AN - 1622291029; 201408509 AB - Researchers and practitioners alike often struggle to develop sufficient library research skills in this digital era and in so doing struggle further to find best practices in mental health. This article delineates the most up-to-date resources for websites, journal articles, and other library resources. Resources include international, national, state, and professional organizations and insurance providers. Adapted from the source document. JF - Best Practices in Mental Health AU - Paynter, Robin AD - U.S. Department of Health and Human Services, Agency for Healthcare Research and Quality, Effective Health Care Program, in Portland, OR Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 54 EP - 58 PB - Lyceum Books, Chicago, IL VL - 10 IS - 1 SN - 1553-555X, 1553-555X KW - evidence-based practice searching KW - Skills KW - Libraries KW - Mental Health KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1622291029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Best+Practices+in+Mental+Health&rft.atitle=A+Pathfinder+Resource+for+Best+Practices+in+Mental+Health&rft.au=Paynter%2C+Robin&rft.aulast=Paynter&rft.aufirst=Robin&rft.date=2014-04-01&rft.volume=10&rft.issue=1&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Best+Practices+in+Mental+Health&rft.issn=1553555X&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2014-11-01 N1 - Number of references - 1 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Libraries; Mental Health; Skills ER - TY - JOUR T1 - Coronary artery disease and cancer mortality in a cohort of workers exposed to vinyl chloride, carbon disulfide, rotating shift work, and o-toluidine at a chemical manufacturing plant AN - 1560139169; 19431727 AB - Background We updated through 2007 the mortality experience of 1,874 workers employed at a New York State chemical manufacturing plant between 1946 and 2006. Methods Reassessed exposures to vinyl chloride, carbon disulfide, and shift work and categories of o-toluidine exposure were based on year, department and job title. Standardized mortality ratios (SMR) compared mortality to that of the US population. Internal comparisons used directly standardized rate ratios. Results Hepatobiliary cancer mortality was elevated among workers ever exposed to vinyl chloride (SMR=3.80, 95% confidence interval 1.89-6.80); directly standardized rates increased with increasing vinyl chloride exposure duration. No increase in non-Hodgkin lymphoma mortality was observed with vinyl chloride and shift work exposures. Internal comparisons showed increased coronary artery disease mortality among long-term workers exposed to carbon disulfide and shift work for 4 years or more. Conclusions Excess coronary artery disease mortality confirms earlier results; further investigation is needed to understand risk factors. Am. J. Ind. Med. 57:398-411, 2014. copyright 2014 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Carreon, Tania AU - Hein, Misty J AU - Hanley, Kevin W AU - Viet, Susan M AU - Ruder, Avima M AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 398 EP - 411 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 4 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - cohort mortality KW - chemical manufacturing KW - vinyl chloride KW - carbon disulfide KW - o-toluidine KW - shift work KW - cancer KW - coronary artery disease KW - Manufacturing industry KW - Mortality KW - Plant diseases KW - Working conditions KW - Cancer KW - USA, New York KW - Carbon disulfide KW - Shift work KW - Health risks KW - Non-Hodgkin's lymphoma KW - Workers KW - Risk factors KW - Standards KW - Lymphoma KW - Vinyl chloride KW - Occupational exposure KW - Heart diseases KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560139169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Coronary+artery+disease+and+cancer+mortality+in+a+cohort+of+workers+exposed+to+vinyl+chloride%2C+carbon+disulfide%2C+rotating+shift+work%2C+and+o-toluidine+at+a+chemical+manufacturing+plant&rft.au=Carreon%2C+Tania%3BHein%2C+Misty+J%3BHanley%2C+Kevin+W%3BViet%2C+Susan+M%3BRuder%2C+Avima+M&rft.aulast=Carreon&rft.aufirst=Tania&rft.date=2014-04-01&rft.volume=57&rft.issue=4&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22299 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-11-12 N1 - SubjectsTermNotLitGenreText - Carbon disulfide; Workers; Mortality; Plant diseases; Risk factors; o-toluidine; Lymphoma; Cancer; Occupational exposure; Vinyl chloride; Heart diseases; Non-Hodgkin's lymphoma; Health risks; Manufacturing industry; Shift work; Standards; Working conditions; USA, New York DO - http://dx.doi.org/10.1002/ajim.22299 ER - TY - JOUR T1 - Retrospective cohort study of a microelectronics and business machine facility AN - 1560138253; 19431729 AB - Objectives We examined health outcomes among 34,494 workers employed at a microelectronics and business machine facility 1969-2001. Methods Standardized mortality ratio (SMR) and standardized incidence ratios were used to evaluate health outcomes in the cohort and Cox regression modeling to evaluate relations between scores for occupational exposures and outcomes of a priori interest. Results Just over 17% of the cohort (5,966 people) had died through 2009. All cause, all cancer, and many cause-specific SMRs showed statistically significant deficits. In hourly males, SMRs were significantly elevated for non-Hodgkin's lymphoma and rectal cancer. Salaried males had excess testicular cancer incidence. Pleural cancer and mesothelioma excesses were observed in workers hired before 1969, but no available records substantiate use of asbestos in manufacturing processes. A positive, statistically significant relation was observed between exposure scores for tetrachloroethylene and nervous system diseases. Conclusions Few significant exposure-outcome relations were observed, but risks from occupational exposures cannot be ruled out due to data limitations and the relative youth of the cohort. Am. J. Ind. Med. 57:412-424, 2014. copyright 2013 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Silver, Sharon R AU - Pinkerton, Lynne E AU - Fleming, Donald A AU - Jones, James H AU - Allee, Steven AU - Luo, Lian AU - Bertke, Stephen J AD - Division of Surveillance, Hazard Assessment and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio. Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 412 EP - 424 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 4 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - occupation KW - cancer KW - chemicals KW - Health risks KW - Mortality KW - Manufacturing industry KW - Non-Hodgkin's lymphoma KW - Asbestos KW - Mesothelioma KW - Standards KW - Occupational exposure KW - Cancer KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560138253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Retrospective+cohort+study+of+a+microelectronics+and+business+machine+facility&rft.au=Silver%2C+Sharon+R%3BPinkerton%2C+Lynne+E%3BFleming%2C+Donald+A%3BJones%2C+James+H%3BAllee%2C+Steven%3BLuo%2C+Lian%3BBertke%2C+Stephen+J&rft.aulast=Silver&rft.aufirst=Sharon&rft.date=2014-04-01&rft.volume=57&rft.issue=4&rft.spage=412&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22288 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Non-Hodgkin's lymphoma; Manufacturing industry; Mortality; Health risks; Asbestos; Mesothelioma; Standards; Cancer; Occupational exposure DO - http://dx.doi.org/10.1002/ajim.22288 ER - TY - JOUR T1 - Equine Facilitated Therapy with Children and Adolescents Who Have Been Sexually Abused: A Program Evaluation Study AN - 1558986957; 201429920 AB - Child sexual abuse (CSA) is a social problem that often inflicts long lasting psychological trauma and leads to psychopathology, behavioural problems and re-victimization. Treating young people who are presenting with the detrimental effects of CSA is often difficult because these effects off-set efforts at establishing a therapeutic bond. Animals have been found to facilitate the development of the therapeutic alliance between client and practitioner and therapies utilizing horses have the added bonus of empowering clients. This study aimed to evaluate an Equine Facilitated Program (EFT) run by Phoenix House, a sexual assault referral centre in Queensland, Australia. Participants were six boys and nine girls (aged 8-11 years) and 15 adolescent girls (aged 12-17 years). All participants provided several measures of data designed to establish levels of psychological distress at three points in time. That is, Time 1-intake into the service; Time 2-following approximately 6 weeks of in-clinic counselling and pre-EFT; and Time 3 post-EFT (9-10 week duration). Significant improvements in functioning were found between Time 2 and Time 3 assessment across all psychometric measures and for both age groups. No, or non-significant, improvements were found between Time 1 and Time 2 assessments. Overall the results show that EFT proved an effective therapeutic approach for the children and adolescents referred to the service. Of particular note was the finding that efficacy was similar across gender, age and Indigenous/non-Indigenous status. Implications of this and suggestions for further research are discussed. Adapted from the source document. JF - Journal of Child and Family Studies AU - Kemp, Kathleen AU - Signal, Tania AU - Botros, Helena AU - Taylor, Nik AU - Prentice, Kathy AD - Department of Health and Human Services, Central Queensland University, Rockhampton, QLD, Australia Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 558 EP - 566 PB - Springer, Dordrecht The Netherlands VL - 23 IS - 3 SN - 1062-1024, 1062-1024 KW - Assessment KW - Houses KW - Psychological distress KW - Gender KW - Children KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558986957?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+and+Family+Studies&rft.atitle=Equine+Facilitated+Therapy+with+Children+and+Adolescents+Who+Have+Been+Sexually+Abused%3A+A+Program+Evaluation+Study&rft.au=Kemp%2C+Kathleen%3BSignal%2C+Tania%3BBotros%2C+Helena%3BTaylor%2C+Nik%3BPrentice%2C+Kathy&rft.aulast=Kemp&rft.aufirst=Kathleen&rft.date=2014-04-01&rft.volume=23&rft.issue=3&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+and+Family+Studies&rft.issn=10621024&rft_id=info:doi/10.1007%2Fs10826-013-9718-1 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 50 N1 - Last updated - 2016-09-27 N1 - CODEN - JCFSES N1 - SubjectsTermNotLitGenreText - Adolescents; Children; Assessment; Gender; Houses; Psychological distress DO - http://dx.doi.org/10.1007/s10826-013-9718-1 ER - TY - JOUR T1 - County Workforce, Reimbursement, and Organizational Factors Associated with Behavioral Health Capacity in Health Centers AN - 1558986366; 201429823 AB - This study describes on-site behavioral health treatment capacity in health centers in 2007 and examines whether capacity was associated with health center characteristics, county-level behavioral health workforce, and same-day billing restrictions. Cross-sectional data from the 2007 Area Resource File and Uniform Data System were linked with data on Medicaid same-day billing restrictions. Mental health treatment capacity was common; almost four in five health centers provided on-site mental health services. Additional services such as crisis counseling (20 %), treatment from a psychiatrist (29 %), and substance abuse treatment were offered by fewer health centers (51 % provide on-site services and only 20 % employ substance abuse specialists). In multivariate analysis, larger health centers, health centers located in counties with a larger behavioral health workforce per capita, and those located in the West and Northeast were more likely to have behavioral health capacity. Same-day billing restrictions were associated with lower odds of substance use treatment capacity and providing 24 hr crisis counseling services. Adapted from the source document. JF - The Journal of Behavioral Health Services & Research AU - Jones, Emily AU - Ku, Leighton AU - Smith, Shelagh AU - Lardiere, Michael AD - Office of Economic Analysis, Evaluation, and Modeling in the Office of the National Coordinator for Health Information Technology, United States Department of Health and Human Services, Washington, DC, USA emilybjones@gmail.com Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 125 EP - 139 PB - Springer, US VL - 41 IS - 2 SN - 1094-3412, 1094-3412 KW - Mental health services KW - Occupational health and safety KW - Labour force KW - Social services KW - Charges KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1558986366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.atitle=County+Workforce%2C+Reimbursement%2C+and+Organizational+Factors+Associated+with+Behavioral+Health+Capacity+in+Health+Centers&rft.au=Jones%2C+Emily%3BKu%2C+Leighton%3BSmith%2C+Shelagh%3BLardiere%2C+Michael&rft.aulast=Jones&rft.aufirst=Emily&rft.date=2014-04-01&rft.volume=41&rft.issue=2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Behavioral+Health+Services+%26+Research&rft.issn=10943412&rft_id=info:doi/10.1007%2Fs11414-013-9364-9 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-09-01 N1 - Number of references - 34 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Occupational health and safety; Substance abuse; Mental health services; Charges; Labour force; Social services DO - http://dx.doi.org/10.1007/s11414-013-9364-9 ER - TY - JOUR T1 - Genetic Variants in the Major Histocompatibility Complex Class I and Class II Genes Are Associated With Diisocyanate-Induced Asthma AN - 1544007929; 20180121 AB - Objective: To investigate the association between single nucleotide polymorphisms (SNPs) located across the major histocompatibility complex and susceptibility to diisocyanate-induced asthma (DA). Methods: The study population consisted of 140 diisocyanate-exposed workers. Genotyping was performed using the Illumina GoldenGate major histocompatibility complex panels. Results: The HLA-E rs1573294 and HLA-DPB1 rs928976 SNPs were associated with an increased risk of DA under dominant (odds ratio [OR], 6.27; 95% confidence interval [CI], 2.37 to 16.6; OR, 2.79, 95% CI, 0.99 to 7.81, respectively) and recessive genetic models (OR, 6.27, 95% CI, 1.63 to 24.13; OR, 10.10, 95% CI, 3.16 to 32.33, respectively). The HLA-B rs1811197, HLA-DOA rs3128935, and HLA-DQA2 rs7773955 SNPs conferred an increased risk of DA in a dominant model (OR, 7.64, 95% CI, 2.25 to 26.00; OR, 19.69, 95% CI, 2.89 to 135.25; OR, 8.43, 95% CI, 3.03 to 23.48, respectively). Conclusion: These results suggest that genetic variations within HLA genes play a role in DA risk. JF - Journal of Occupational and Environmental Medicine AU - Yucesoy, Berran AU - Johnson, Victor J AU - Lummus, Zana L AU - Kashon, Michael L AU - Rao, Marepalli AU - Bannerman-Thompson, Hansen AU - Frye, Bonnie AU - Wang, Wei AU - Gautrin, Denyse AU - Cartier, Andre AU - Boulet, Louis-Philippe AU - Sastre, Joaquin AU - Quirce, Santiago AU - Tarlo, Susan M AU - Germolec, Dori R AU - Luster, Michael I AU - Bernstein, David I AD - Health Effects Laboratory Division, NIOSH/CDC, Morgantown, WV 26505; Division of Immunology, Allergy and Rheumatology, College of Medicine, University of Cincinnati, Cincinnati, OH 45267-0563, yucesobn@ucmail.uc.edu PY - 2014 SP - 382 EP - 387 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 56 IS - 4 SN - 1076-2752, 1076-2752 KW - Genetics Abstracts; Risk Abstracts; Health & Safety Science Abstracts KW - Histocompatibility antigen HLA KW - Genotyping KW - Genetic diversity KW - Major histocompatibility complex KW - Asthma KW - Population studies KW - Respiratory diseases KW - Models KW - Workers KW - Dopamine KW - Single-nucleotide polymorphism KW - G 07720:Immunogenetics KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1544007929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Genetic+Variants+in+the+Major+Histocompatibility+Complex+Class+I+and+Class+II+Genes+Are+Associated+With+Diisocyanate-Induced+Asthma&rft.au=Yucesoy%2C+Berran%3BJohnson%2C+Victor+J%3BLummus%2C+Zana+L%3BKashon%2C+Michael+L%3BRao%2C+Marepalli%3BBannerman-Thompson%2C+Hansen%3BFrye%2C+Bonnie%3BWang%2C+Wei%3BGautrin%2C+Denyse%3BCartier%2C+Andre%3BBoulet%2C+Louis-Philippe%3BSastre%2C+Joaquin%3BQuirce%2C+Santiago%3BTarlo%2C+Susan+M%3BGermolec%2C+Dori+R%3BLuster%2C+Michael+I%3BBernstein%2C+David+I&rft.aulast=Yucesoy&rft.aufirst=Berran&rft.date=2014-04-01&rft.volume=56&rft.issue=4&rft.spage=382&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000138 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Workers; Dopamine; Single-nucleotide polymorphism; Genotyping; Population studies; Asthma; Major histocompatibility complex; Models; Genetic diversity; Respiratory diseases DO - http://dx.doi.org/10.1097/JOM.0000000000000138 ER - TY - JOUR T1 - Prevalence of Workers With Shifts in Hearing by Industry: A Comparison of OSHA and NIOSH Hearing Shift Criteria AN - 1543998084; 20180132 AB - Objective: The purpose of this study was to compare the prevalence of workers with National Institute for Occupational Safety and Health significant threshold shifts (NSTS), Occupational Safety and Health Administration standard threshold shifts (OSTS), and with OSTS with age correction (OSTS-A), by industry using North American Industry Classification System codes. Methods: From 2001 to 2010, worker audiograms were examined. Prevalence and adjusted prevalence ratios for NSTS were estimated by industry. NSTS, OSTS, and OSTS-A prevalences were compared by industry. Results: Twenty percent of workers had an NSTS, 14% had an OSTS, and 6% had an OSTS-A. JF - Journal of Occupational and Environmental Medicine AU - Masterson, Elizabeth A AU - Sweeney, Marie Haring AU - Deddens, James A AU - Themann, Christa L AU - Wall, David K AD - National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention, Cincinnati, OH; Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS-R17, Cincinnati, OH 45226, EMasterson@cdc.gov PY - 2014 SP - 446 EP - 455 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 56 IS - 4 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - North America KW - Age KW - Federal regulations KW - Safety regulations KW - Classification KW - Occupational safety KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1543998084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Prevalence+of+Workers+With+Shifts+in+Hearing+by+Industry%3A+A+Comparison+of+OSHA+and+NIOSH+Hearing+Shift+Criteria&rft.au=Masterson%2C+Elizabeth+A%3BSweeney%2C+Marie+Haring%3BDeddens%2C+James+A%3BThemann%2C+Christa+L%3BWall%2C+David+K&rft.aulast=Masterson&rft.aufirst=Elizabeth&rft.date=2014-04-01&rft.volume=56&rft.issue=4&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000124 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Federal regulations; Age; Safety regulations; Classification; Occupational safety; North America DO - http://dx.doi.org/10.1097/JOM.0000000000000124 ER - TY - JOUR T1 - A comparative pharmacokinetic estimate of mercury in US infants following yearly exposures to inactivated influenza vaccines containing thimerosal AN - 1528878011; 4563696 AB - The use of thimerosal preservative in childhood vaccines has been largely eliminated over the past decade in the United States because vaccines have been reformulated in single-dose vials that do not require preservative. An exception is the inactivated influenza vaccines, which are formulated in both multidose vials requiring preservative and preservative-free single-dose vials. As part of an ongoing evaluation by USFDA of the safety of biologics throughout their lifecycle, the infant body burden of mercury following scheduled exposures to thimerosal preservative in inactivated influenza vaccines in the United States was estimated and compared to the infant body burden of mercury following daily exposures to dietary methylmercury at the reference dose established by the USEPA. Body burdens were estimated using kinetic parameters derived from experiments conducted in infant monkeys that were exposed episodically to thimerosal or MeHg at identical doses. We found that the body burden of mercury (AUC) in infants (including low birth weight) over the first 4.5 years of life following yearly exposures to thimerosal was two orders of magnitude lower than that estimated for exposures to the lowest regulatory threshold for MeHg over the same time period. In addition, peak body burdens of mercury following episodic exposures to thimerosal in this worst-case analysis did not exceed the corresponding safe body burden of mercury from methylmercury at any time, even for low-birth-weight infants. Our pharmacokinetic analysis supports the acknowledged safety of thimerosal when used as a preservative at current levels in certain multidose infant vaccines in the United States. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Walderhaug, Mark O AU - Forshee, Richard A AU - Mitkus, Robert J AU - King, David B AD - US Food and Drug Administration Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 735 EP - 750 VL - 34 IS - 4 SN - 0272-4332, 0272-4332 KW - Sociology KW - Evaluation KW - Experiments KW - Body weight KW - Childhood KW - Estimation KW - U.S.A. KW - Immunization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1528878011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=A+comparative+pharmacokinetic+estimate+of+mercury+in+US+infants+following+yearly+exposures+to+inactivated+influenza+vaccines+containing+thimerosal&rft.au=Walderhaug%2C+Mark+O%3BForshee%2C+Richard+A%3BMitkus%2C+Robert+J%3BKing%2C+David+B&rft.aulast=Walderhaug&rft.aufirst=Mark&rft.date=2014-04-01&rft.volume=34&rft.issue=4&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Frisa.12124 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-05-27 N1 - Last updated - 2014-05-28 N1 - SubjectsTermNotLitGenreText - 6237 5775 13521; 2211 652 5676 646 6091 2212; 4636 6845 6564 12622; Body weight; 4403 7854; 4551; 433 293 14 DO - http://dx.doi.org/10.1111/risa.12124 ER - TY - JOUR T1 - Consumer Understanding of the Benefits and Risks of Fish Consumption During Pregnancy AN - 1524416196; 19519745 AB - Fish consumption during pregnancy is one important area of dietary advice. There are potential benefits for pregnant women and their babies from a diet that contains sufficient amounts of fish. However, methylmercury, which is in most fish in at least trace amounts, can have adverse effects on the cognitive development of fetuses and can have neurological effects on children and adults in high amounts. The Federal government first issued national consumption advice in order to minimize the risk to the developing fetus from methylmercury in fish in the 1990s. This advice was updated in 2001 and again in 2004. Most recently, the US Dietary Guidelines for Americans, 2010 recommends a consumption target for pregnant and nursing women of 8 to 12 oz/wk of a variety of fish lower in methyl-mercury-to take advantage of the potential benefits that fish could provide to children's development- while avoiding the 4 fish species highest in methylmercury that are named in joint 2004 Food and Drug Administration/Environmental Protection Agency advice (tilefish, shark, swordfish, and king mackerel). The challenge for policy makers, public health officials, and clinicians is to determine how best to communicate with pregnant women about both the benefits and risks associated with fish consumption. JF - American Journal of Lifestyle Medicine AU - Lando, Amy M AU - Lo, Serena C AD - Center for Food Safety and Applied Nutrition, US Food and Drug Administration, College Park, Maryland Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 88 EP - 92 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 8 IS - 2 SN - 1559-8276, 1559-8276 KW - Health & Safety Science Abstracts; Risk Abstracts; Oceanic Abstracts; ASFA 1: Biological Sciences & Living Resources KW - fish consumption KW - pregnancy KW - risk communication KW - Risk reduction KW - Risks KW - Public health KW - Marine fish KW - Fishery policy KW - Fish consumption KW - Consumers KW - Seafood KW - Diets KW - Marine KW - Methylmercury KW - Methyl mercury KW - Guidelines KW - Children KW - Fetuses KW - Pregnancy KW - Sharks KW - EPA KW - Cognitive ability KW - Scomber KW - Fish KW - Governments KW - Side effects KW - H 9000:Consumer and Recreation Safety KW - O 5040:Processing, Products and Marketing KW - Q1 08422:Environmental effects KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524416196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Lifestyle+Medicine&rft.atitle=Consumer+Understanding+of+the+Benefits+and+Risks+of+Fish+Consumption+During+Pregnancy&rft.au=Lando%2C+Amy+M%3BLo%2C+Serena+C&rft.aulast=Lando&rft.aufirst=Amy&rft.date=2014-04-01&rft.volume=8&rft.issue=2&rft.spage=88&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Lifestyle+Medicine&rft.issn=15598276&rft_id=info:doi/10.1177%2F1559827613514704 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Number of references - 32 N1 - Last updated - 2015-08-19 N1 - SubjectsTermNotLitGenreText - Fishery policy; Marine fish; Methyl mercury; Fish consumption; Consumers; Governments; Risks; Public health; Pregnancy; Diets; Methylmercury; Guidelines; Risk reduction; Children; Fetuses; Sharks; EPA; Cognitive ability; Fish; Seafood; Side effects; Scomber; Marine DO - http://dx.doi.org/10.1177/1559827613514704 ER - TY - JOUR T1 - Toxicology and Chemical Food Safety in the Journal of Food Science: 1936 - the present AN - 1524398388; 19641064 JF - Journal of Food Science AU - Jackson, Lauren S AD - Scientific Editor, Toxicology and Chemical Food Safety Food and Drug Administration. Institute for Food Safety & Health Y1 - 2014/04// PY - 2014 DA - April 2014 SP - iv EP - v PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 79 IS - 4 SN - 0022-1147, 0022-1147 KW - Health & Safety Science Abstracts KW - Food contamination KW - Toxicology KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524398388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+Science&rft.atitle=Toxicology+and+Chemical+Food+Safety+in+the+Journal+of+Food+Science%3A+1936+-+the+present&rft.au=Jackson%2C+Lauren+S&rft.aulast=Jackson&rft.aufirst=Lauren&rft.date=2014-04-01&rft.volume=79&rft.issue=4&rft.spage=iv&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+Science&rft.issn=00221147&rft_id=info:doi/10.1111%2F1750-3841.12452 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Food contamination; Toxicology DO - http://dx.doi.org/10.1111/1750-3841.12452 ER - TY - JOUR T1 - Blood substitutes: why haven't we been more successful? AN - 1520735048; 24630491 AB - Persistent safety concerns have stalled the development of viable hemoglobin (Hb)-based oxygen carriers (HBOCs). HBOCs have several advantages over human blood, including availability, long-term storage, and lack of infectious risk. The basis of HBOC toxicity is poorly understood, however, several mechanisms have been suggested, including Hb extravasation across the blood vessel wall, scavenging of endothelial nitric oxide (NO), oversupply of oxygen, and heme-mediated oxidative side reactions. Although there are some in vitro and limited animal studies supporting these mechanisms, heme-mediated reactivity appears to provide an alternative path that can explain some of the observed pathophysiological changes. Moreover, recent mechanistic and animal studies support a role for globin and heme scavengers in controlling oxidative toxicity associated with Hb infusion. Published by Elsevier Ltd. JF - Trends in biotechnology AU - Alayash, Abdu I AD - Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. Electronic address: abdu.alayash@fda.hhs.gov. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 177 EP - 185 VL - 32 IS - 4 KW - Blood Substitutes KW - 0 KW - Hemoglobins KW - Heme KW - 42VZT0U6YR KW - Index Medicus KW - Hemoglobin KW - Oxidative toxicity KW - Blood substitutes KW - Animals KW - Models, Molecular KW - Humans KW - Oxidative Stress KW - Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520735048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+biotechnology&rft.atitle=Blood+substitutes%3A+why+haven%27t+we+been+more+successful%3F&rft.au=Alayash%2C+Abdu+I&rft.aulast=Alayash&rft.aufirst=Abdu&rft.date=2014-04-01&rft.volume=32&rft.issue=4&rft.spage=177&rft.isbn=&rft.btitle=&rft.title=Trends+in+biotechnology&rft.issn=1879-3096&rft_id=info:doi/10.1016%2Fj.tibtech.2014.02.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-17 N1 - Date created - 2014-03-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Clin Lab Med. 2010 Jun;30(2):381-9 [20513557] Artif Cells Blood Substit Immobil Biotechnol. 2010 Apr;38(2):64-8 [20196683] Trends Mol Med. 2010 Oct;16(10):447-57 [20708968] Am J Pathol. 2011 Mar;178(3):1316-28 [21356382] Antioxid Redox Signal. 2011 May 1;14(9):1713-28 [20954814] Protein Sci. 2011 May;20(5):791-805 [21404362] Med J Aust. 2011 May 2;194(9):471-3 [21534906] Injury. 2012 May;43(5):638-47 [21094491] Antioxid Redox Signal. 2012 Sep 1;17(5):813-46 [22324321] Transfusion. 2013 Feb;53(2):424-37 [22804568] J Biol Chem. 2013 Feb 8;288(6):4288-98 [23264625] Blood. 2013 Feb 21;121(8):1276-84 [23264591] Antioxid Redox Signal. 2013 Jun 10;18(17):2314-28 [23025383] J Biol Chem. 2013 Aug 2;288(31):22408-25 [23775069] Blood. 2014 Jan 16;123(3):377-90 [24277079] J Biol Chem. 2002 Jul 19;277(29):26194-9 [12006567] Biochem Soc Trans. 2002 Aug;30(4):745-8 [12196184] Crit Care Med. 2003 Jun;31(6):1824-30 [12794426] Anesth Analg. 2004 Mar;98(3):604-10, table of contents [14980905] Nat Rev Drug Discov. 2004 Feb;3(2):152-9 [15043006] Artif Organs. 2004 Sep;28(9):813-28 [15320945] Transfusion. 2004 Oct;44(10):1516-30 [15383027] Artif Cells Blood Substit Immobil Biotechnol. 2004;32(3):353-74 [15508274] Arch Biochem Biophys. 1993 Jun;303(2):332-8 [8512319] Biochemistry. 1996 Jun 4;35(22):6976-83 [8679521] J Neurotrauma. 1996 Apr;13(4):223-31 [8860203] World J Surg. 1996 Nov-Dec;20(9):1200-7 [8864082] J Lab Clin Med. 1997 Jun;129(6):603-10 [9178726] J Cereb Blood Flow Metab. 1998 Mar;18(3):257-73 [9498842] J Appl Physiol (1985). 1998 Sep;85(3):993-1003 [9729575] Am J Respir Cell Mol Biol. 2005 Apr;32(4):257-61 [15778415] Nat Biotechnol. 1999 Jun;17(6):545-9 [10385317] Artif Cells Blood Substit Immobil Biotechnol. 1999 Mar;27(2):93-107 [10092932] Nature. 2005 Jun 2;435(7042):697-701 [15931225] Protein J. 2005 Apr;24(3):133-46 [16096719] Anal Chem. 2006 Jul 1;78(13):4634-41 [16808476] Biochem J. 2006 Nov 1;399(3):513-24 [16848758] J Biol Chem. 2007 Feb 16;282(7):4894-907 [17178725] J Biol Chem. 2007 Jul 13;282(28):20221-9 [17502383] J Pharmacol Exp Ther. 2007 Oct;323(1):49-60 [17622572] Biochem J. 2008 Sep 15;414(3):461-9 [18498252] Biochim Biophys Acta. 2008 Oct;1784(10):1382-6 [18555029] Blood. 2009 Mar 12;113(11):2578-86 [19131549] Crit Care Clin. 2009 Apr;25(2):311-24, Table of Contents [19341911] J Clin Invest. 2009 Aug;119(8):2271-80 [19620788] Clinics (Sao Paulo). 2009;64(8):803-13 [19690667] Anesthesiology. 2009 Nov;111(5):946-63 [19858869] Antioxid Redox Signal. 2010 Oct 1;13(7):1087-123 [20170402] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tibtech.2014.02.006 ER - TY - JOUR T1 - Widening Rural-Urban Disparities in All-Cause Mortality and Mortality from Major Causes of Death in the USA, 1969-2009 AN - 1520386781; 19633836 AB - This study examined trends in rural-urban disparities in all-cause and cause-specific mortality in the USA between 1969 and 2009. A rural-urban continuum measure was linked to county-level mortality data. Age-adjusted death rates were calculated by sex, race, cause-of-death, area-poverty, and urbanization level for 13 time periods between 1969 and 2009. Cause-of-death decomposition and log-linear and Poisson regression were used to analyze rural-urban differentials. Mortality rates increased with increasing levels of rurality overall and for non-Hispanic whites, blacks, and American Indians/Alaska Natives. Despite the declining mortality trends, mortality risks for both males and females and for blacks and whites have been increasingly higher in non-metropolitan than metropolitan areas, particularly since 1990. In 2005-2009, mortality rates varied from 391.9 per 100,000 population for Asians/Pacific Islanders in rural areas to 1,063.2 for blacks in small-urban towns. Poverty gradients were steeper in rural areas, which maintained higher mortality than urban areas after adjustment for poverty level. Poor blacks in non-metropolitan areas experienced two to three times higher all-cause and premature mortality risks than affluent blacks and whites in metropolitan areas. Disparities widened over time; excess mortality from all causes combined and from several major causes of death in non-metropolitan areas was greater in 2005-2009 than in 1990-1992. Causes of death contributing most to the increasing rural-urban disparity and higher rural mortality include heart disease, unintentional injuries, COPD, lung cancer, stroke, suicide, diabetes, nephritis, pneumonia/influenza, cirrhosis, and Alzheimer's disease. Residents in metropolitan areas experienced larger mortality reductions during the past four decades than non-metropolitan residents, contributing to the widening gap. JF - Journal of Urban Health AU - Singh, Gopal K AU - Siahpush, Mohammad AD - Maternal and Child Health Bureau, Health Resources and Services Administration, US Department of Health and Human Services, 5600 Fishers Lane, Room 18-41, Rockville, MD, 20857, USA, gsingh@hrsa.gov Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 272 EP - 292 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 91 IS - 2 SN - 1099-3460, 1099-3460 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Injuries KW - Urbanization KW - Alzheimer's disease KW - Stroke KW - Suicide KW - INE, USA, Alaska KW - Towns KW - Diabetes mellitus KW - Poverty KW - Ethnic groups KW - Metropolitan areas KW - Lung cancer KW - Heart diseases KW - Rural areas KW - H 11000:Diseases/Injuries/Trauma KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520386781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Urban+Health&rft.atitle=Widening+Rural-Urban+Disparities+in+All-Cause+Mortality+and+Mortality+from+Major+Causes+of+Death+in+the+USA%2C+1969-2009&rft.au=Singh%2C+Gopal+K%3BSiahpush%2C+Mohammad&rft.aulast=Singh&rft.aufirst=Gopal&rft.date=2014-04-01&rft.volume=91&rft.issue=2&rft.spage=272&rft.isbn=&rft.btitle=&rft.title=Journal+of+Urban+Health&rft.issn=10993460&rft_id=info:doi/10.1007%2Fs11524-013-9847-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 46 N1 - Last updated - 2016-09-14 N1 - SubjectsTermNotLitGenreText - Mortality; Urbanization; Injuries; Stroke; Alzheimer's disease; Suicide; Towns; Diabetes mellitus; Poverty; Metropolitan areas; Ethnic groups; Rural areas; Heart diseases; Lung cancer; INE, USA, Alaska DO - http://dx.doi.org/10.1007/s11524-013-9847-2 ER - TY - JOUR T1 - T-bet Regulates Immunity to Francisella tularensis Live Vaccine Strain Infection, Particularly in Lungs AN - 1520385853; 19634206 AB - Upregulation of the transcription factor T-bet is correlated with the strength of protection against secondary challenge with the live vaccine strain (LVS) of Francisella tularensis. Thus, to determine if this mediator had direct consequences in immunity to LVS, we examined its role in infection. Despite substantial in vivo gamma interferon (IFN- gamma ) levels, T-bet-knockout (KO) mice infected intradermally (i.d.) or intranasally (i.n.) with LVS succumbed to infection with doses 2 log units less than those required for their wild-type (WT) counterparts, and exhibited significantly increased bacterial burdens in the lung and spleen. Lungs of LVS-infected T-bet-KO mice contained fewer lymphocytes and more neutrophils and interleukin-17 than WT mice. LVS-vaccinated T-bet-KO mice survived lethal LVS intraperitoneal secondary challenge but not high doses of LVS i.n. challenge, independently of the route of vaccination. Immune T lymphocytes from the spleens of i.d. LVS-vaccinated WT or KO mice controlled intracellular bacterial replication in an in vitro coculture system, but cultures with T-bet-KO splenocyte supernatants contained less IFN- gamma and increased amounts of tumor necrosis factor alpha. In contrast, immune T-bet-KO lung lymphocytes were greatly impaired in controlling intramacrophage growth of LVS; this functional defect is the likely mechanism underpinning the lack of respiratory protection. Taken together, T-bet is important in host resistance to primary LVS infection and i.n. secondary challenge. Thus, T-bet represents a true, useful correlate for immunity to LVS. JF - Infection and Immunity AU - Melillo, Amanda A AU - Foreman, Oded AU - Bosio, Catharine M AU - Elkins, Karen L AD - Laboratory of Mycobacterial Diseases and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Rockville, Maryland, USA, karen.elkins@fda.hhs.gov. Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 1477 EP - 1490 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 82 IS - 4 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Replication KW - Leukocytes (neutrophilic) KW - Spleen KW - Francisella tularensis KW - Immunity KW - Infection KW - Vaccination KW - Splenocytes KW - Lung KW - Transcription factors KW - Interleukin 17 KW - Lymphocytes T KW - Tumor necrosis factor- alpha KW - Vaccines KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520385853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=T-bet+Regulates+Immunity+to+Francisella+tularensis+Live+Vaccine+Strain+Infection%2C+Particularly+in+Lungs&rft.au=Melillo%2C+Amanda+A%3BForeman%2C+Oded%3BBosio%2C+Catharine+M%3BElkins%2C+Karen+L&rft.aulast=Melillo&rft.aufirst=Amanda&rft.date=2014-04-01&rft.volume=82&rft.issue=4&rft.spage=1477&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/10.1128%2FIAI.01545-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 42 N1 - Last updated - 2014-07-24 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Replication; Leukocytes (neutrophilic); Spleen; Immunity; Infection; Vaccination; Splenocytes; Lung; Interleukin 17; Transcription factors; Lymphocytes T; Vaccines; Tumor necrosis factor- alpha; Francisella tularensis DO - http://dx.doi.org/10.1128/IAI.01545-13 ER - TY - JOUR T1 - Diacetyl Increases Sensory Innervation and Substance P Production in Rat Trachea AN - 1520377845; 19503696 AB - Inhalation of diacetyl, a butter flavoring, causes airway responses potentially mediated by sensory nerves. This study examines diacetyl-induced changes in sensory nerves of tracheal epithelium. Rats (n = 6/group) inhaled 0-, 25-, 249-, or 346-ppm diacetyl for 6 hr. Tracheas and vagal ganglia were removed 1-day postexposure and labeled for substance P (SP) or protein gene product 9.5 (PGP9.5). Vagal ganglia neurons projecting to airway epithelium were identified by axonal transport of fluorescent microspheres intratracheally instilled 14 days before diacetyl inhalation. End points were SP and PGP9.5 nerve fiber density (NFD) in tracheal epithelium and SP-positive neurons projecting to the trachea. PGP9.5-immunoreactive NFD decreased in foci with denuded epithelium, suggesting loss of airway sensory innervation. However, in the intact epithelium adjacent to denuded foci, SP-immunoreactive NFD increased from 0.01 plus or minus 0.002 in controls to 0.05 plus or minus 0.01 after exposure to 346-ppm diacetyl. In vagal ganglia, SP-positive airway neurons increased from 3.3 plus or minus 3.0% in controls to 25.5 plus or minus 6.6% after inhaling 346-ppm diacetyl. Thus, diacetyl inhalation increases SP levels in sensory nerves of airway epithelium. Because SP release in airways promotes inflammation and activation of sensory nerves mediates reflexes, neural changes may contribute to flavorings-related lung disease pathogenesis. JF - Toxicologic Pathology AU - Goravanahally, Madhusudan P AU - Hubbs, Ann F AU - Fedan, Jeffery S AU - Kashon, Michael L AU - Battelli, Lori A AU - Mercer, Robert R AU - Goldsmith, WTravis AU - Jackson, Mark C AU - Cumpston, Amy AU - Frazer, David G AU - Dey, Richard D AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA, Department of Neurobiology and Anatomy, West Virginia University, Morgantown, West Virginia, USA, rdey@hsc.wvu.edu Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 582 EP - 590 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU United Kingdom VL - 42 IS - 3 SN - 0192-6233, 0192-6233 KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - flavorings KW - inhalation toxicity KW - airway epithelium KW - airway innervation KW - airway inflammation KW - cough KW - Innervation KW - Inhalation KW - Axonal transport KW - Sensory neurons KW - Lung diseases KW - Flavorings KW - Vagus nerve KW - Substance P KW - Diacetyl KW - Inflammation KW - Fibers KW - Reflexes KW - Butter KW - Neurons KW - microspheres KW - Epithelium KW - Trachea KW - protein gene product 9.5 KW - Respiratory tract KW - N3 11028:Neuropharmacology & toxicology KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520377845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Diacetyl+Increases+Sensory+Innervation+and+Substance+P+Production+in+Rat+Trachea&rft.au=Goravanahally%2C+Madhusudan+P%3BHubbs%2C+Ann+F%3BFedan%2C+Jeffery+S%3BKashon%2C+Michael+L%3BBattelli%2C+Lori+A%3BMercer%2C+Robert+R%3BGoldsmith%2C+WTravis%3BJackson%2C+Mark+C%3BCumpston%2C+Amy%3BFrazer%2C+David+G%3BDey%2C+Richard+D&rft.aulast=Goravanahally&rft.aufirst=Madhusudan&rft.date=2014-04-01&rft.volume=42&rft.issue=3&rft.spage=582&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1177%2F0192623313493689 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 55 N1 - Last updated - 2015-04-02 N1 - SubjectsTermNotLitGenreText - Inhalation; Innervation; Axonal transport; Sensory neurons; Lung diseases; Flavorings; Vagus nerve; Diacetyl; Substance P; Inflammation; Fibers; Reflexes; Butter; Neurons; microspheres; Epithelium; Trachea; protein gene product 9.5; Respiratory tract DO - http://dx.doi.org/10.1177/0192623313493689 ER - TY - JOUR T1 - Adiabatic inversion pulses for myocardial T1 mapping AN - 1520377711; 19634666 AB - Purpose To evaluate the error in T1 estimates using inversion-recovery-based T1 mapping due to imperfect inversion and to perform a systematic study of adiabatic inversion pulse designs in order to maximize inversion efficiency for values of transverse relaxation (T2) in the myocardium subject to a peak power constraint. Methods The inversion factor for hyperbolic secant and tangent/hyperbolic tangent adiabatic full passage waveforms was calculated using Bloch equations. A brute-force search was conducted for design parameters: pulse duration, frequency range, shape parameters, and peak amplitude. A design was selected that maximized the inversion factor over a specified range of amplitude and off-resonance and validated using phantom measurements. Empirical correction for imperfect inversion was performed. Results The tangent/hyperbolic tangent adiabatic pulse was found to outperform hyperbolic secant designs and achieve an inversion factor of 0.96 within plus or minus 150 Hz over 25% amplitude range with 14.7 mu T peak amplitude. T1 mapping errors of the selected design due to imperfect inversion was 4% and could be corrected to <1%. Conclusions Nonideal inversion leads to significant errors in inversion-recovery-based T1 mapping. The inversion efficiency of adiabatic pulses is sensitive to transverse relaxation. The tangent/hyperbolic tangent design achieved the best performance subject to the peak amplitude constraint. Magn Reson Med 71:1428-1434, 2014. copyright 2013 Wiley Periodicals, Inc. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Herzka, Daniel A AU - Hansen, Michael Schacht AD - National Institutes of Health, Department of Health and Human Services, National Heart, Lung and Blood Institute, Bethesda, Maryland, USA. Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 1428 EP - 1434 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 71 IS - 4 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Mathematical models KW - Inversion KW - Adiabatic KW - N.M.R. KW - Mapping KW - Myocardium KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520377711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Adiabatic+inversion+pulses+for+myocardial+T1+mapping&rft.au=Kellman%2C+Peter%3BHerzka%2C+Daniel+A%3BHansen%2C+Michael+Schacht&rft.aulast=Kellman&rft.aufirst=Peter&rft.date=2014-04-01&rft.volume=71&rft.issue=4&rft.spage=1428&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.24793 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Mathematical models; Inversion; Adiabatic; N.M.R.; Mapping; Myocardium DO - http://dx.doi.org/10.1002/mrm.24793 ER - TY - JOUR T1 - Updated evaluation of the migration of styrene monomer and oligomers from polystyrene food contact materials to foods and food simulants. AN - 1517878189; 24383702 AB - Due to the 2011 labelling of styrene monomer as "reasonably anticipated to be a human carcinogen" by the National Institutes of Health's National Toxicology Program (NTP) and the controversy over whether styrene oligomers mimic the physiological effects of estrogen, an updated review of styrene monomer and oligomers in food and food contact materials (FCMs) was performed. The concentrations of styrene monomer and oligomers were determined in 24 polystyrene (PS) products and ranged from 9.3 to 3100 mg kg(-1) for the styrene monomer, 130-2900 mg kg(-1) for the sum of three styrene dimers, and 220-16,000 mg kg(-1) for the sum of six styrene trimers. Foods in contact with PS packaging had styrene monomer concentrations ranging from 2.6 to 163 ng g(-1); dimer concentrations from the limit of quantitation (LOQ) to 4.8 ng g(-1) and trimer concentrations were all below the LOQ (2 ng g(-1)). Diffusion coefficients (Dp) and partition coefficients (K) were also calculated for styrene dimers and trimers. The results presented here indicate that styrene monomer concentrations in foods have not significantly changed since the 1980s and monomer concentrations in food packaging quantified in this study were all below USFDA limits. Although styrene dimers and trimers are present in higher concentrations in PS FCMs than the monomer, their migration to food is limited because of their high K values (4 × 10(2) to 2 × 10(6)) and their low diffusion coefficients in PS products. Additionally, diffusion coefficients calculated using USFDA-recommended food simulants and Arrhenius plots describing the temperature dependence of styrene dimers and trimers can be used in future calculations of dietary intake of the styrene oligomers. JF - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment AU - Genualdi, Susan AU - Nyman, Patricia AU - Begley, Timothy AD - a Center for Food Safety and Applied Nutrition , US Food and Drug Administration , College Park , MD , USA. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 723 EP - 733 VL - 31 IS - 4 KW - Polystyrenes KW - 0 KW - Styrene KW - 44LJ2U959V KW - Index Medicus KW - diffusion coefficients KW - migration KW - food packaging KW - styrene monomer KW - styrene dimer KW - polystyrene KW - styrene trimer KW - Food -- classification KW - Styrene -- chemistry KW - Food Analysis KW - Food Contamination KW - Polystyrenes -- chemistry KW - Food Packaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1517878189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.atitle=Updated+evaluation+of+the+migration+of+styrene+monomer+and+oligomers+from+polystyrene+food+contact+materials+to+foods+and+food+simulants.&rft.au=Genualdi%2C+Susan%3BNyman%2C+Patricia%3BBegley%2C+Timothy&rft.aulast=Genualdi&rft.aufirst=Susan&rft.date=2014-04-01&rft.volume=31&rft.issue=4&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Food+additives+%26+contaminants.+Part+A%2C+Chemistry%2C+analysis%2C+control%2C+exposure+%26+risk+assessment&rft.issn=1944-0057&rft_id=info:doi/10.1080%2F19440049.2013.878040 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-12 N1 - Date created - 2014-04-17 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1080/19440049.2013.878040 ER - TY - JOUR T1 - Evaluation of a Loop-Mediated Isothermal Amplification Suite for the Rapid, Reliable, and Robust Detection of Shiga Toxin-Producing Escherichia coli in Produce AN - 1516752364; 19533474 AB - Shiga toxin-producing Escherichia coli (STEC) strains are a leading cause of produce-associated outbreaks in the United States. Rapid, reliable, and robust detection methods are needed to better ensure produce safety. We recently developed a loop-mediated isothermal amplification (LAMP) suite for STEC detection. In this study, the STEC LAMP suite was comprehensively evaluated against real-time quantitative PCR (qPCR) using a large panel of bacterial strains (n = 156) and various produce items (several varieties of lettuce, spinach, and sprouts). To simulate real-world contamination events, produce samples were surface inoculated with a low level (1.2 to 1.8 CFU/25 g) of individual STEC strains belonging to seven serogroups (O26, O45, O103, O111, O121, O145, and O157) and held at 4 degree C for 48 h before testing. Six DNA extraction methods were also compared using produce enrichment broths. All STEC targets and their subtypes were accurately detected by the LAMP suite. The detection limits were 1 to 20 cells per reaction in pure culture and 105 to 106 CFU per 25 g (i.e., 103 to 104 CFU per g) in produce, except for strains harboring the stx2c, eae- beta , and eae-[thetas] subtypes. After 6 to 8 h of enrichment, the LAMP suite achieved accurate detection of low levels of STEC strains of various stx2 and eae subtypes in lettuce and spinach varieties but not in sprouts. A similar trend of detection was observed for qPCR. The PrepMan Ultra sample preparation reagent yielded the best results among the six DNA extraction methods. This research provided a rapid, reliable, and robust method for detecting STEC in produce during routine sampling and testing. The challenge with sprouts detection by both LAMP and qPCR calls for special attention to further analysis. JF - Applied and Environmental Microbiology AU - Wang, Fei AU - Yang, Qianru AU - Qu, Yinzhi AU - Meng, Jianghong AU - Ge, Beilei AD - Division of Animal and Food Microbiology, Office of Research, Center for Veterinary Medicine, U.S. Food and Drug Administration, Laurel, Maryland, USA, beilei.ge@fda.hhs.gov. Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 2516 EP - 2525 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 80 IS - 8 SN - 0099-2240, 0099-2240 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Pure culture KW - Contamination KW - Colony-forming cells KW - Escherichia coli KW - Polymerase chain reaction KW - Spinacia oleracea KW - Sampling KW - Experimental allergic encephalomyelitis KW - X 24310:Pharmaceuticals KW - J 02400:Human Diseases KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516752364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Evaluation+of+a+Loop-Mediated+Isothermal+Amplification+Suite+for+the+Rapid%2C+Reliable%2C+and+Robust+Detection+of+Shiga+Toxin-Producing+Escherichia+coli+in+Produce&rft.au=Wang%2C+Fei%3BYang%2C+Qianru%3BQu%2C+Yinzhi%3BMeng%2C+Jianghong%3BGe%2C+Beilei&rft.aulast=Wang&rft.aufirst=Fei&rft.date=2014-04-01&rft.volume=80&rft.issue=8&rft.spage=2516&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/10.1128%2FAEM.04203-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Number of references - 52 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Pure culture; Contamination; Colony-forming cells; Polymerase chain reaction; Sampling; Experimental allergic encephalomyelitis; Escherichia coli; Spinacia oleracea DO - http://dx.doi.org/10.1128/AEM.04203-13 ER - TY - JOUR T1 - Immune-related conditions and subsequent risk of brain cancer in a cohort of 4.5 million male US veterans AN - 1516746449; 19543137 AB - Background: Case-control studies have reported an inverse association between self-reported history of allergy and risk of glioma, but cohort data are limited. Our objectives were to evaluate the associations of major groups of medically diagnosed immune-related conditions (allergy/atopy, autoimmune disease, diabetes, infectious/inflammatory disease) and to explore associations with specific conditions in relation to subsequent diagnosis of brain cancer in a large cohort study. Methods: We used hospital discharge records for a cohort of 4.5 million male US veterans, of whom 4383 developed primary brain cancer. Rate ratios (RRs) and 95% confidence intervals (CIs) were calculated using time-dependent Poisson regression. Results: We found a significant trend of decreasing RRs for brain cancer with longer duration of allergy/atopy (P=0.02), but not for other conditions studied. Rate ratios of brain cancer for allergy/atopy and diabetes with duration of 10 or more years were 0.60 (95% CI: 0.43, 0.83) and 0.75 (95% CI: 0.62, 0.93), respectively. Several associations with specific conditions were found, but these did not withstand correction for multiple comparisons. Conclusions: This study lends some support to an inverse association between allergy/atopy and diabetes of long duration and brain cancer risk, but prospective studies with biological samples are needed to uncover the underlying biological mechanisms. JF - British Journal of Cancer AU - Cahoon, E K AU - Inskip, P D AU - Gridley, G AU - Brenner, A V AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA Y1 - 2014/04/01/ PY - 2014 DA - 2014 Apr 01 SP - 1825 EP - 1833 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 110 IS - 7 SN - 0007-0920, 0007-0920 KW - Immunology Abstracts; Risk Abstracts KW - Historical account KW - Data processing KW - Males KW - Autoimmune diseases KW - Brain KW - Allergies KW - Cancer KW - Diabetes mellitus KW - Brain tumors KW - Health risks KW - USA KW - Hypersensitivity KW - Atopy KW - Inflammatory diseases KW - Glioma KW - Hospitals KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516746449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Immune-related+conditions+and+subsequent+risk+of+brain+cancer+in+a+cohort+of+4.5+million+male+US+veterans&rft.au=Cahoon%2C+E+K%3BInskip%2C+P+D%3BGridley%2C+G%3BBrenner%2C+A+V&rft.aulast=Cahoon&rft.aufirst=E&rft.date=2014-04-01&rft.volume=110&rft.issue=7&rft.spage=1825&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fbjc.2014.97 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2014-07-24 N1 - SubjectsTermNotLitGenreText - Brain tumors; Diabetes mellitus; Hypersensitivity; Data processing; Inflammatory diseases; Atopy; Autoimmune diseases; Brain; Glioma; Hospitals; Historical account; Health risks; Males; Allergies; Cancer; USA DO - http://dx.doi.org/10.1038/bjc.2014.97 ER - TY - JOUR T1 - Multiple poisonings with sodium azide at a local restaurant. AN - 1511821623; 24262061 AB - Sodium azide is a chemical with a mechanism similar to cyanide. There is concern that it could be used as a chemical warfare agent. We report a cluster of poisonings that occurred at a public restaurant and the subsequent investigation that identified iced tea contaminated with sodium azide (NaN3) and hydrazoic acid, as the foodborne vehicle and agents, respectively. Five patients became ill within minutes of drinking iced tea at a restaurant. They all presented to the same Emergency Department with similar symptoms, and improved with fluids, antiemetics, and supportive care. A joint investigation by the Dallas County Department of Health and Human Services, the Texas State Health Department, the Dallas County Southwestern Institute of Forensic Sciences, and the medical toxicologists at the University of Texas Southwestern School of Medicine identified iced tea, contaminated with sodium azide (NaN3) and hydrazoic acid, as the foodborne vehicle and agents, respectively. The recurrence, and seriousness, of these events suggests a need for continued education of emergency providers. Emergency physicians should consider exposures to toxic chemicals in their differential when a cluster of patients presents with similar symptoms over a short period of time. Copyright © 2014 Elsevier Inc. All rights reserved. JF - The Journal of emergency medicine AU - Schwarz, Evan S AU - Wax, Paul M AU - Kleinschmidt, Kurt C AU - Sharma, Kapil AU - Chung, Wendy M AU - Cantu, Gabriela AU - Spargo, Erin AU - Todd, Elizabeth AD - Division of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri. ; Division of Emergency Medicine, University of Texas Southwestern School of Medicine, Dallas, Texas. ; Department of Pediatrics, University of Texas Southwestern School of Medicine, Dallas, Texas; Dallas County Department of Health and Human Services, Dallas, Texas. ; Dallas County Department of Health and Human Services, Dallas, Texas. ; Dallas County Southwestern Institute of Forensic Sciences, Dallas, Texas. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 491 EP - 494 VL - 46 IS - 4 SN - 0736-4679, 0736-4679 KW - Azides KW - 0 KW - Tea KW - Vasodilator Agents KW - hydrazoic acid KW - 6P5C4D5D7I KW - Sodium Azide KW - 968JJ8C9DV KW - Index Medicus KW - terrorism KW - sodium azide KW - poisoning KW - metabolic inhibitors KW - Restaurants KW - Texas -- epidemiology KW - Humans KW - Adult KW - Middle Aged KW - Disease Outbreaks KW - Male KW - Female KW - Sodium Azide -- poisoning KW - Vasodilator Agents -- analysis KW - Vasodilator Agents -- poisoning KW - Azides -- analysis KW - Azides -- poisoning KW - Sodium Azide -- analysis KW - Food Contamination KW - Tea -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1511821623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+emergency+medicine&rft.atitle=Multiple+poisonings+with+sodium+azide+at+a+local+restaurant.&rft.au=Schwarz%2C+Evan+S%3BWax%2C+Paul+M%3BKleinschmidt%2C+Kurt+C%3BSharma%2C+Kapil%3BChung%2C+Wendy+M%3BCantu%2C+Gabriela%3BSpargo%2C+Erin%3BTodd%2C+Elizabeth&rft.aulast=Schwarz&rft.aufirst=Evan&rft.date=2014-04-01&rft.volume=46&rft.issue=4&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+emergency+medicine&rft.issn=07364679&rft_id=info:doi/10.1016%2Fj.jemermed.2013.08.082 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-08 N1 - Date created - 2014-03-31 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jemermed.2013.08.082 ER - TY - JOUR T1 - Vertical allometry: fact or fiction? AN - 1511392880; 24534003 AB - In pharmacokinetics, vertical allometry is referred to the clearance of a drug when the predicted human clearance is substantially higher than the observed human clearance. Vertical allometry was initially reported for diazepam based on a 33-fold higher human predicted clearance than the observed human clearance. In recent years, it has been found that many other drugs besides diazepam, can be classified as drugs which exhibit vertical allometry. Over the years, many questions regarding vertical allometry have been raised. For example, (1) How to define and identify the vertical allometry? (2) How much difference should be between predicted and observed human clearance values before a drug could be declared 'a drug which follows vertical allometry'? (3) If somehow one can identify vertical allometry from animal data, how this information can be used for reasonably accurate prediction of clearance in humans? This report attempts to answer the aforementioned questions. The concept of vertical allometry at this time remains complex and obscure but with more extensive works one can have better understanding of 'vertical allometry'. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Mahmood, Iftekhar AU - Boxenbaum, Harold AD - Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research, Food & Drug Administration, 1401 Rockville Pike, Rockville, MD, USA. Electronic address: Iftekhar.mahmood@fda.hhs.gov. ; Office of Blood Review & Research (OBRR), Center for Biologic Evaluation and Research, Food & Drug Administration, 1401 Rockville Pike, Rockville, MD, USA. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 468 EP - 474 VL - 68 IS - 3 KW - Blood Proteins KW - 0 KW - Index Medicus KW - Volume of distribution KW - Vertical allometry KW - Allometric scaling KW - Clearance KW - Body Weight KW - Animals KW - Humans KW - Brain -- anatomy & histology KW - Metabolic Clearance Rate KW - Blood Proteins -- metabolism KW - Protein Binding KW - Organ Size KW - Longevity KW - Models, Biological KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1511392880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Vertical+allometry%3A+fact+or+fiction%3F&rft.au=Mahmood%2C+Iftekhar%3BBoxenbaum%2C+Harold&rft.aulast=Mahmood&rft.aufirst=Iftekhar&rft.date=2014-04-01&rft.volume=68&rft.issue=3&rft.spage=468&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.02.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-01 N1 - Date created - 2014-03-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.02.005 ER - TY - JOUR T1 - Workshop report: strategies for setting occupational exposure limits for engineered nanomaterials. AN - 1511392786; 24462629 AB - Occupational exposure limits (OELs) are important tools for managing worker exposures to chemicals; however, hazard data for many engineered nanomaterials (ENMs) are insufficient for deriving OELs by traditional methods. Technical challenges and questions about how best to measure worker exposures to ENMs also pose barriers to implementing OELs. New varieties of ENMs are being developed and introduced into commerce at a rapid pace, further compounding the issue of OEL development for ENMs. A Workshop on Strategies for Setting Occupational Exposure Limits for Engineered Nanomaterials, held in September 2012, provided an opportunity for occupational health experts from various stakeholder groups to discuss possible alternative approaches for setting OELs for ENMs and issues related to their implementation. This report summarizes the workshop proceedings and findings, identifies areas for additional research, and suggests potential avenues for further progress on this important topic. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved. JF - Regulatory toxicology and pharmacology : RTP AU - Gordon, Steven C AU - Butala, John H AU - Carter, Janet M AU - Elder, Alison AU - Gordon, Terry AU - Gray, George AU - Sayre, Philip G AU - Schulte, Paul A AU - Tsai, Candace S AU - West, Jay AD - 3M Company, Toxicology Assessment and Compliance Assurance, 3M Center, Bldg. 220-6E-03, Saint Paul, MN 55144, USA. Electronic address: scgordon@mmm.com. ; Toxicology Consultants, Inc., 7 Glasgow Road, Gibsonia, PA 15044, USA. Electronic address: butala@jhbutala.com. ; U.S. Department of Labor, Occupational Safety & Health Administration, 200 Constitution Avenue, Washington, DC 20210, USA. Electronic address: carter.janet@dol.gov. ; University of Rochester, School of Medicine and Dentistry, Dept. of Environmental Medicine, 601 Elmwood Ave, Box EHSC, Rochester, NY 14642, USA. Electronic address: alison_elder@urmc.rochester.edu. ; New York University School of Medicine, Department of Environmental Medicine, 57 Old Forge Road, Tuxedo Park, NY 10987, USA. Electronic address: terry.gordon@nyumc.org. ; George Washington University, School of Public Health and Health Services, Dept. of Environmental and Occupational Health and Center for Risk Science and Public Health, 2100 M Street NW, Suite 203A, Washington, DC 20037, USA. Electronic address: gmgray@gwu.edu. ; U.S. Environmental Protection Agency (Mail Code 7403), 1200 Pennsylvania Avenue NW, Washington, DC 20460, USA. Electronic address: sayre.phil@epa.gov. ; National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, USA. Electronic address: pas4@cdc.gov. ; Purdue University, School of Health Sciences, Delon and Elizabeth Hampton Hall of Civil Engineering, 550 Stadium Mall Drive, West Lafayette, IN 47907, USA. Electronic address: tsai51@purdue.edu. ; American Chemistry Council, Nanotechnology Panel, 700 2nd Street NE, Washington, DC 20002, USA. Electronic address: jay_west@americanchemistry.com. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 305 EP - 311 VL - 68 IS - 3 KW - Air Pollutants, Occupational KW - 0 KW - Index Medicus KW - ENM KW - OEL KW - Engineered nanomaterial KW - Occupational exposure limit KW - Alternatives KW - Workshop KW - Strategies KW - Threshold Limit Values KW - Animals KW - Humans KW - Nanostructures -- standards KW - Occupational Exposure -- standards KW - Inhalation Exposure -- standards KW - Air Pollutants, Occupational -- toxicity KW - Air Pollutants, Occupational -- standards KW - Nanostructures -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1511392786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Workshop+report%3A+strategies+for+setting+occupational+exposure+limits+for+engineered+nanomaterials.&rft.au=Gordon%2C+Steven+C%3BButala%2C+John+H%3BCarter%2C+Janet+M%3BElder%2C+Alison%3BGordon%2C+Terry%3BGray%2C+George%3BSayre%2C+Philip+G%3BSchulte%2C+Paul+A%3BTsai%2C+Candace+S%3BWest%2C+Jay&rft.aulast=Gordon&rft.aufirst=Steven&rft.date=2014-04-01&rft.volume=68&rft.issue=3&rft.spage=305&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2014.01.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-01 N1 - Date created - 2014-03-28 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2014.01.005 ER - TY - JOUR T1 - Pulmonary immune responses to Aspergillus fumigatus in an immunocompetent mouse model of repeated exposures. AN - 1508941977; 23919459 AB - Aspergillus fumigatus is a filamentous fungus that produces abundant pigmented conidia. Several fungal components have been identified as virulence factors, including melanin; however, the impact of these factors in a repeated exposure model resembling natural environmental exposures remains unknown. This study examined the role of fungal melanin in the stimulation of pulmonary immune responses using immunocompetent BALB/c mice in a multiple exposure model. It compared conidia from wild-type A. fumigatus to two melanin mutants of the same strain, Δarp2 (tan) or Δalb1 (white). Mass spectrometry-based analysis of conidial extracts demonstrated that there was little difference in the protein fingerprint profiles between the three strains. Field emission scanning electron microscopy demonstrated that the immunologically inert Rodlet A layer remained intact in melanin-deficient conidia. Thus, the primary difference between the strains was the extent of melanization. Histopathology indicated that each A. fumigatus strain induced lung inflammation, regardless of the extent of melanization. In mice exposed to Δalb1 conidia, an increase in airway eosinophils and a decrease in neutrophils and CD8(+) IL-17(+) (Tc17) cells were observed. Additionally, it was shown that melanin mutant conidia were more rapidly cleared from the lungs than wild-type conidia. These data suggest that the presence of fungal melanin may modulate the pulmonary immune response in a mouse model of repeated exposures to A. fumigatus conidia. JF - Journal of immunotoxicology AU - Buskirk, Amanda D AU - Templeton, Steven P AU - Nayak, Ajay P AU - Hettick, Justin M AU - Law, Brandon F AU - Green, Brett J AU - Beezhold, Donald H AD - Allergy and Clinical Immunology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention , Morgantown, WV , USA . PY - 2014 SP - 180 EP - 189 VL - 11 IS - 2 KW - Melanins KW - 0 KW - Index Medicus KW - Models, Animal KW - Animals KW - Neutrophils -- immunology KW - Melanins -- physiology KW - CD8-Positive T-Lymphocytes -- immunology KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - Environmental Exposure KW - Mice KW - Mice, Inbred BALB C KW - Female KW - Lung -- immunology KW - Aspergillus fumigatus -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1508941977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotoxicology&rft.atitle=Pulmonary+immune+responses+to+Aspergillus+fumigatus+in+an+immunocompetent+mouse+model+of+repeated+exposures.&rft.au=Buskirk%2C+Amanda+D%3BTempleton%2C+Steven+P%3BNayak%2C+Ajay+P%3BHettick%2C+Justin+M%3BLaw%2C+Brandon+F%3BGreen%2C+Brett+J%3BBeezhold%2C+Donald+H&rft.aulast=Buskirk&rft.aufirst=Amanda&rft.date=2014-04-01&rft.volume=11&rft.issue=2&rft.spage=180&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotoxicology&rft.issn=1547-6901&rft_id=info:doi/10.3109%2F1547691X.2013.819054 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-22 N1 - Date created - 2014-03-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Tuberc Lung Dis. 2009 Aug;13(8):936-44 [19723372] Nature. 2009 Aug 27;460(7259):1117-21 [19713928] Crit Rev Toxicol. 2009;39(10):799-864 [19863384] J Immunol. 2009 Dec 1;183(11):7161-8 [19917680] Br J Dermatol. 2009 Dec;161(6):1301-6 [19785613] J Immunol. 2010 Apr 15;184(8):4215-27 [20237297] Cell Immunol. 2010;264(1):97-103 [20553755] J Immunol. 2010 Aug 15;185(4):2089-98 [20624947] Immunobiology. 2010 Nov;215(11):915-20 [19939494] Curr Opin Immunol. 2010 Dec;22(6):821-6 [21087848] Anal Biochem. 2011 Apr 1;411(1):122-8 [21094115] PLoS One. 2011;6(4):e18777 [21533200] Cell Microbiol. 2011 Aug;13(8):1130-48 [21501368] Blood. 2012 Jan 26;119(4):967-77 [22147891] Infect Immun. 2012 Apr;80(4):1424-36 [22252873] J Bacteriol. 1982 Jun;150(3):1414-21 [6804444] J Allergy Clin Immunol. 2003 Nov;112(5):935-43 [14610483] Annu Rev Immunol. 2012;30:115-48 [22224780] J Med Vet Mycol. 1987 Apr;25(2):97-106 [3598824] Curr Top Med Mycol. 1988;2:338-87 [3288360] J Allergy Clin Immunol. 1990 Nov;86(5):726-31 [2229838] J Immunol. 1995 Oct 1;155(7):3507-16 [7561046] Mol Microbiol. 1997 Oct;26(1):175-83 [9383199] Infect Immun. 1997 Dec;65(12):5110-7 [9393803] Clin Infect Dis. 1998 Apr;26(4):781-803; quiz 804-5 [9564455] J Bacteriol. 1998 Jun;180(12):3031-8 [9620950] Med Microbiol Immunol. 1998 Oct;187(2):79-89 [9832321] Infect Immun. 2000 Jun;68(6):3736-9 [10816538] Clin Microbiol Rev. 2000 Oct;13(4):708-17 [11023965] Trends Microbiol. 2001 Aug;9(8):382-9 [11514221] Am J Respir Cell Mol Biol. 2003 Jan;28(1):42-50 [12495931] Appl Environ Microbiol. 2003 Mar;69(3):1581-8 [12620846] J Toxicol Environ Health A. 2003 Aug 8;66(15):1441-52 [12857634] Clin Microbiol Rev. 1999 Apr;12(2):310-50 [10194462] J Bacteriol. 1999 Oct;181(20):6469-77 [10515939] Contrib Microbiol. 1999;2:205-15 [10523276] Immunity. 2006 Oct;25(4):665-75 [17027299] Nat Rev Immunol. 2006 Nov;6(11):869-74 [17063187] J Immunol. 2007 Jun 15;178(12):7879-89 [17548626] J Immunol Methods. 2007 Oct 31;327(1-2):63-74 [17716680] Int Arch Allergy Immunol. 2008;145(1):58-86 [17709917] J Immunol. 2008 May 1;180(9):6000-9 [18424720] Anal Biochem. 2008 Sep 15;380(2):276-81 [18577370] J Immunol. 2009 Mar 15;182(6):3469-81 [19265125] Eur J Immunol. 2009 Mar;39(3):645-8 [19283705] J Immunol. 2009 Apr 15;182(8):4938-46 [19342673] J Allergy Clin Immunol. 2009 May;123(5):986-94; quiz 995-6 [19410688] Annu Rev Immunol. 2009;27:485-517 [19132915] Int J Immunopathol Pharmacol. 2009 Apr-Jun;22(2):287-97 [19505382] BMC Microbiol. 2009;9:177 [19703288] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/1547691X.2013.819054 ER - TY - JOUR T1 - Whole-genome single-nucleotide-polymorphism analysis for discrimination of Clostridium botulinum group I strains. AN - 1507191019; 24463972 AB - Clostridium botulinum is a genetically diverse Gram-positive bacterium producing extremely potent neurotoxins (botulinum neurotoxins A through G [BoNT/A-G]). The complete genome sequences of three strains harboring only the BoNT/A1 nucleotide sequence are publicly available. Although these strains contain a toxin cluster (HA(+) OrfX(-)) associated with hemagglutinin genes, little is known about the genomes of subtype A1 strains (termed HA(-) OrfX(+)) that lack hemagglutinin genes in the toxin gene cluster. We sequenced the genomes of three BoNT/A1-producing C. botulinum strains: two strains with the HA(+) OrfX(-) cluster (69A and 32A) and one strain with the HA(-) OrfX(+) cluster (CDC297). Whole-genome phylogenic single-nucleotide-polymorphism (SNP) analysis of these strains along with other publicly available C. botulinum group I strains revealed five distinct lineages. Strains 69A and 32A clustered with the C. botulinum type A1 Hall group, and strain CDC297 clustered with the C. botulinum type Ba4 strain 657. This study reports the use of whole-genome SNP sequence analysis for discrimination of C. botulinum group I strains and demonstrates the utility of this analysis in quickly differentiating C. botulinum strains harboring identical toxin gene subtypes. This analysis further supports previous work showing that strains CDC297 and 657 likely evolved from a common ancestor and independently acquired separate BoNT/A1 toxin gene clusters at distinct genomic locations. JF - Applied and environmental microbiology AU - Gonzalez-Escalona, Narjol AU - Timme, Ruth AU - Raphael, Brian H AU - Zink, Donald AU - Sharma, Shashi K AD - Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, Maryland, USA. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 2125 EP - 2132 VL - 80 IS - 7 KW - DNA, Bacterial KW - 0 KW - Index Medicus KW - Genotype KW - DNA, Bacterial -- chemistry KW - DNA, Bacterial -- genetics KW - Molecular Sequence Data KW - Sequence Analysis, DNA KW - Molecular Diagnostic Techniques -- methods KW - Cluster Analysis KW - Polymorphism, Single Nucleotide KW - Clostridium botulinum -- classification KW - Genome, Bacterial KW - Bacteriological Techniques -- methods KW - Clostridium botulinum -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1507191019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+environmental+microbiology&rft.atitle=Whole-genome+single-nucleotide-polymorphism+analysis+for+discrimination+of+Clostridium+botulinum+group+I+strains.&rft.au=Gonzalez-Escalona%2C+Narjol%3BTimme%2C+Ruth%3BRaphael%2C+Brian+H%3BZink%2C+Donald%3BSharma%2C+Shashi+K&rft.aulast=Gonzalez-Escalona&rft.aufirst=Narjol&rft.date=2014-04-01&rft.volume=80&rft.issue=7&rft.spage=2125&rft.isbn=&rft.btitle=&rft.title=Applied+and+environmental+microbiology&rft.issn=1098-5336&rft_id=info:doi/10.1128%2FAEM.03934-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-15 N1 - Date created - 2014-03-12 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - AQPU00000000; GENBANK; AQPV00000000; AQPT00000000 N1 - SuppNotes - Cited By: JAMA. 2001 Feb 28;285(8):1059-70 [11209178] Genome Biol Evol. 2013;5(11):2109-23 [24158624] J Appl Microbiol. 1998 Jan;84(1):5-17 [15244052] J Mol Evol. 1980 Dec;16(2):111-20 [7463489] J Clin Microbiol. 1985 Apr;21(4):654-5 [3988908] J Clin Microbiol. 1986 Jan;23(1):201-2 [3517043] J Clin Microbiol. 1991 Nov;29(11):2618-20 [1774272] Neurotox Res. 2006 Dec;10(3-4):263-87 [17197375] J Bacteriol. 2007 Feb;189(3):818-32 [17114256] Genome Res. 2007 Jul;17(7):1082-92 [17519437] Biochem Biophys Res Commun. 2007 Sep 14;361(1):49-54 [17658467] PLoS One. 2007;2(12):e1271 [18060065] BMC Genomics. 2008;9:75 [18261238] J Neural Transm (Vienna). 2008;115(4):575-7 [18363030] Appl Environ Microbiol. 2008 May;74(9):2778-86 [18326685] Appl Environ Microbiol. 2008 Jul;74(14):4390-7 [18502928] Microbiology. 2008 Aug;154(Pt 8):2408-15 [18667573] Syst Biol. 2008 Oct;57(5):758-71 [18853362] Appl Environ Microbiol. 2009 May;75(9):2643-51 [19270141] BMC Genomics. 2009;10:115 [19298644] BMC Biol. 2009;7:66 [19804621] Appl Environ Microbiol. 2010 Nov;76(22):7653-7 [20889791] N Engl J Med. 2011 Jan 6;364(1):33-42 [21142692] BMC Genomics. 2010;11:725 [21182778] J Bacteriol. 2011 May;193(9):2351-2 [21378191] BMC Genomics. 2011;12:185 [21486474] N Engl J Med. 2011 Aug 25;365(8):709-17 [21793740] Mol Biol Evol. 2011 Oct;28(10):2731-9 [21546353] Toxins (Basel). 2011 Jan;3(1):63-81 [22069690] BMC Microbiol. 2011;11:232 [22008244] Appl Environ Microbiol. 2011 Dec;77(24):8648-55 [22003026] BMC Genomics. 2012;13:32 [22260654] PLoS One. 2013;8(1):e54287 [23365658] PLoS One. 2013;8(1):e55254 [23383127] Annu Rev Microbiol. 2002;56:167-85 [12142472] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1128/AEM.03934-13 ER - TY - JOUR T1 - High daily dose and being a substrate of cytochrome P450 enzymes are two important predictors of drug-induced liver injury. AN - 1507188986; 24464804 AB - Drug-induced liver injury (DILI) is complicated and difficult to predict. It has been observed that drugs with extensive hepatic metabolism have a higher likelihood of causing DILI. Cytochrome P450 (P450) enzymes are primarily involved in hepatic metabolism. Identifying the associations of DILI with drugs that are P450 substrates, inhibitors, or inducers will be extremely helpful to clinicians during the decision-making process of caring for a patient suspected of having DILI. We collected metabolism data on P450 enzymes for 254 orally administered drugs in the Liver Toxicity Knowledge Base Benchmark Dataset with a known daily dose, and applied logistic regression to identify these associations. We revealed that drugs that are substrates of P450 enzymes have a higher likelihood of causing DILI [odds ratio (OR), 3.99; 95% confidence interval (95% CI), 2.07-7.67; P < 0.0001], which is dose-independent, and drugs that are P450 inhibitors have a higher likelihood of generating DILI only when they are administered at high daily doses (OR, 6.03; 95% CI, 1.32-27.5; P = 0.0098). However, drugs that are P450 inducers are not observed to be associated with DILI (OR, 1.55; 95% CI, 0.65-3.68; P = 0.3246). Our findings will be useful in identifying the suspected medication as a cause of liver injury in clinical settings. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Yu, Ke AU - Geng, Xingchao AU - Chen, Minjun AU - Zhang, Jie AU - Wang, Bingshun AU - Ilic, Katarina AU - Tong, Weida AD - Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas (K.Y., M.C., J.Z., W.T.); National Center for Safety Evaluation of Drugs, National Institute for Food and Drug Control, China's State Food and Drug Administration, Beijing, China (X.G.); Department of Biostatistics, Shanghai Jiao Tong University School of Medicine, Shanghai, China (B.W.); and Department of Pharmacology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia (K.I.). Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 744 EP - 750 VL - 42 IS - 4 KW - Cytochromes KW - 0 KW - Pharmaceutical Preparations KW - cytochrome P420 KW - 9035-49-8 KW - Index Medicus KW - Administration, Oral KW - Logistic Models KW - Dose-Response Relationship, Drug KW - Humans KW - Databases, Factual KW - Predictive Value of Tests KW - Substrate Specificity KW - Pharmaceutical Preparations -- administration & dosage KW - Pharmaceutical Preparations -- metabolism KW - Cytochromes -- antagonists & inhibitors KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Chemical and Drug Induced Liver Injury -- enzymology KW - Cytochromes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1507188986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=High+daily+dose+and+being+a+substrate+of+cytochrome+P450+enzymes+are+two+important+predictors+of+drug-induced+liver+injury.&rft.au=Yu%2C+Ke%3BGeng%2C+Xingchao%3BChen%2C+Minjun%3BZhang%2C+Jie%3BWang%2C+Bingshun%3BIlic%2C+Katarina%3BTong%2C+Weida&rft.aulast=Yu&rft.aufirst=Ke&rft.date=2014-04-01&rft.volume=42&rft.issue=4&rft.spage=744&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.113.056267 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-28 N1 - Date created - 2014-03-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1124/dmd.113.056267 ER - TY - JOUR T1 - Characterization and preclinical development of LY2603618: a selective and potent Chk1 inhibitor AN - 1504714956; 24114124 AB - Interference with DNA damage checkpoints has been demonstrated preclinically to be a highly effective means of increasing the cytotoxicity of a number of DNA-damaging cancer therapies. Cell cycle arrest at these checkpoints protects injured cells from apoptotic cell death until DNA damage can be repaired. In the absence of functioning DNA damage checkpoints, cells with damaged DNA may proceed into premature mitosis followed by cell death. A key protein kinase involved in activating and maintaining the S and G2/M checkpoints is Chk1. Pharmacological inhibition of Chk1 in the absence of p53 functionality leads to abrogation of DNA damage checkpoints and has been shown preclinically to enhance the activity of many standard of care chemotherapeutic agents. LY2603618 is a potent and selective small molecule inhibitor of Chk1 protein kinase activity in vitro (IC^sub 50^=7 nM) and the first selective Chk1 inhibitor to enter clinical cancer trials. Treatment of cells with LY2603618 produced a cellular phenotype similar to that reported for depletion of Chk1 by RNAi. Inhibition of intracellular Chk1 by LY2603618 results in impaired DNA synthesis, elevated H2A.X phosphorylation indicative of DNA damage and premature entry into mitosis. When HeLa cells were exposed to doxorubicin to induce a G2/M checkpoint arrest, subsequent treatment with LY2603618 released the checkpoint, resulting in cells entering into metaphase with poorly condensed chromosomes. Consistent with abrogation of the Chk1 and p53-dependent G2/M checkpoint, mutant TP53 HT-29 colon cancer cells were more sensitive to gemcitabine when also treated with LY2603618, while wild-type TP53 HCT116 cells were not sensitized by LY2603618 to gemcitabine. Treatment of Calu-6 human mutant TP53 lung cancer cell xenografts with gemcitabine resulted in a stimulation of Chk1 kinase activity that was inhibited by co-administration of LY2603618. By all criteria, LY2603618 is a highly effective inhibitor of multiple aspects of Chk1 biology. [PUBLICATION ABSTRACT] JF - Investigational New Drugs AU - King, Constance AU - Diaz, Henry AU - Barnard, Darlene AU - Barda, David AU - Clawson, David AU - Blosser, Wayne AU - Cox, Karen AU - Guo, Sherry AU - Marshall, Mark Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 213 EP - 26 CY - New York PB - Springer Science & Business Media VL - 32 IS - 2 SN - 01676997 KW - Pharmacy And Pharmacology KW - Antineoplastic Agents KW - LY2603618 KW - Phenylurea Compounds KW - Protein Kinase Inhibitors KW - Pyrazines KW - Tumor Suppressor Protein p53 KW - Deoxycytidine KW - Doxorubicin KW - gemcitabine KW - Protein Kinases KW - Checkpoint kinase 1 KW - Studies KW - Pharmaceutical sciences KW - Inhibitor drugs KW - DNA damage KW - Cytotoxicity KW - Cancer therapies KW - United States--US KW - 8641:Pharmaceuticals industry KW - 8320:Health care industry KW - 9130:Experimental/theoretical KW - 9190:United States KW - Neoplasms -- drug therapy KW - Animals KW - Pyrazines -- therapeutic use KW - DNA Damage KW - Deoxycytidine -- analogs & derivatives KW - Humans KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Protein Kinase Inhibitors -- therapeutic use KW - Doxorubicin -- pharmacology KW - Phenylurea Compounds -- therapeutic use KW - Cell Cycle Checkpoints -- drug effects KW - Tumor Suppressor Protein p53 -- genetics KW - Antineoplastic Agents -- therapeutic use KW - Deoxycytidine -- pharmacology KW - Female KW - Neoplasms -- metabolism KW - Protein Kinases -- metabolism KW - Protein Kinase Inhibitors -- pharmacology KW - Pyrazines -- pharmacology KW - Antineoplastic Agents -- pharmacology KW - Phenylurea Compounds -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504714956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aabiglobal&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+New+Drugs&rft.atitle=Characterization+and+preclinical+development+of+LY2603618%3A+a+selective+and+potent+Chk1+inhibitor&rft.au=King%2C+Constance%3BDiaz%2C+Henry%3BBarnard%2C+Darlene%3BBarda%2C+David%3BClawson%2C+David%3BBlosser%2C+Wayne%3BCox%2C+Karen%3BGuo%2C+Sherry%3BMarshall%2C+Mark&rft.aulast=King&rft.aufirst=Constance&rft.date=2014-04-01&rft.volume=32&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Investigational+New+Drugs&rft.issn=01676997&rft_id=info:doi/10.1007%2Fs10637-013-0036-7 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media New York 2014 N1 - Document feature - Tables; References N1 - Last updated - 2014-11-13 N1 - CODEN - INNDDK N1 - SubjectsTermNotLitGenreText - United States--US DO - http://dx.doi.org/10.1007/s10637-013-0036-7 ER - TY - JOUR T1 - Telmisartan ameliorates glutamate-induced neurotoxicity: roles of AT(1) receptor blockade and PPARγ activation. AN - 1504149624; 24316465 AB - Sartans (Angiotensin II AT(1) Receptor Blockers, ARBs) are powerful neuroprotective agents in vivo and protect against IL-1β neurotoxicity in vitro. The purpose of this research was to determine the extent of sartan neuroprotection against glutamate excitotoxicity, a common cause of neuronal injury and apoptosis. The results show that sartans are neuroprotective, significantly reducing glutamate-induced neuronal injury and apoptosis in cultured rat primary cerebellar granule cells (CGCs). Telmisartan was the most potent sartan studied, with an order of potency telmisartan > candesartan > losartan > valsartan. Mechanisms involved reduction of pro-apoptotic caspase-3 activation, protection of the survival PI3K/Akt/GSK-3β pathway and prevention of glutamate-induced ERK1/2 activation. NMDA receptor stimulation was essential for glutamate-induced cell injury and apoptosis. Participation of AT(1A) receptor was supported by glutamate-induced upregulation of AT(1A) gene expression and AT(1) receptor binding. Conversely, AT(1B) or AT(2) receptors played no role. Glutamate-induced neuronal injury and the neuroprotective effect of telmisartan were decreased, but not abolished, in CGCs obtained from AT(1A) knock-out mice. This indicates that although AT(1) receptors are necessary for glutamate to exert its full neurotoxic potential, part of the neuroprotective effect of telmisartan is independent of AT(1) receptor blockade. PPARγ activation was also involved in the neuroprotective effects of telmisartan, as telmisartan enhanced PPARγ nuclear translocation and the PPARγ antagonist GW9662 partially reversed the neuroprotective effects of telmisartan. The present results substantiate the therapeutic use of sartans, in particular telmisartan, in neurodegenerative diseases and traumatic brain disorders where glutamate neurotoxicity plays a significant role. Published by Elsevier Ltd. JF - Neuropharmacology AU - Wang, Juan AU - Pang, Tao AU - Hafko, Roman AU - Benicky, Julius AU - Sanchez-Lemus, Enrique AU - Saavedra, Juan M AD - Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA. Electronic address: jw543@georgetown.edu. ; Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA; New Drug Screening Center, China Pharmaceutical University, Nanjing 210009, PR China. ; Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA. ; Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA. Electronic address: jb2304@georgetown.edu. ; Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA. Electronic address: scientificsupport@mesoscale.com. ; Section on Pharmacology, Division of Intramural Research Programs, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA; Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC 20057, USA. Electronic address: jms522@georgetown.edu. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 249 EP - 261 VL - 79 KW - Agtr1a protein, mouse KW - 0 KW - Angiotensin II Type 1 Receptor Blockers KW - Benzimidazoles KW - Benzoates KW - Neuroprotective Agents KW - PPAR gamma KW - Receptor, Angiotensin, Type 1 KW - Glutamic Acid KW - 3KX376GY7L KW - telmisartan KW - U5SYW473RQ KW - Index Medicus KW - Apoptosis KW - Angiotensin II AT(1) Receptor Blockers KW - Neuroprotection KW - Telmisartan KW - PPARγ KW - Glutamate neurotoxicity KW - Animals KW - Apoptosis -- physiology KW - Mice KW - Mice, Transgenic KW - Angiotensin II Type 1 Receptor Blockers -- pharmacology KW - Cerebellum -- metabolism KW - Mice, Knockout KW - Rats KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Cerebellum -- drug effects KW - Apoptosis -- drug effects KW - Mice, Inbred C57BL KW - Female KW - Male KW - Glutamic Acid -- toxicity KW - Receptor, Angiotensin, Type 1 -- genetics KW - PPAR gamma -- antagonists & inhibitors KW - Neurons -- drug effects KW - Benzimidazoles -- pharmacology KW - Neurons -- physiology KW - PPAR gamma -- metabolism KW - Receptor, Angiotensin, Type 1 -- metabolism KW - Benzoates -- pharmacology KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1504149624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Telmisartan+ameliorates+glutamate-induced+neurotoxicity%3A+roles+of+AT%281%29+receptor+blockade+and+PPAR%CE%B3+activation.&rft.au=Wang%2C+Juan%3BPang%2C+Tao%3BHafko%2C+Roman%3BBenicky%2C+Julius%3BSanchez-Lemus%2C+Enrique%3BSaavedra%2C+Juan+M&rft.aulast=Wang&rft.aufirst=Juan&rft.date=2014-04-01&rft.volume=79&rft.issue=&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=1873-7064&rft_id=info:doi/10.1016%2Fj.neuropharm.2013.11.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-03 N1 - Date created - 2014-03-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Front Biosci. 2008;13:1813-26 [17981670] Eur J Neurosci. 2008 Jan;27(2):343-51 [18190523] J Neurosci. 2008 Mar 5;28(10):2576-88 [18322101] J Neurosci Res. 2008 Apr;86(5):1096-105 [18041091] J Neurochem. 2008 May;105(3):994-1005 [18088378] J Mol Med (Berl). 2008 Jun;86(6):715-22 [18385968] Brain Res. 2008 Dec 9;1244:164-72 [18948087] Neurobiol Dis. 2008 Dec;32(3):486-98 [18930139] J Vis Exp. 2009;(23). pii: 990. doi: 10.3791/990 [19229177] J Cereb Blood Flow Metab. 2009 Mar;29(3):640-7 [19127280] Chin J Physiol. 2008 Dec 31;51(6):357-62 [19280879] Curr Opin Nephrol Hypertens. 2009 Mar;18(2):128-33 [19434050] Lab Invest. 2009 Aug;89(8):887-902 [19451898] Hypertension. 2009 Oct;54(4):782-7 [19635982] J Hypertens. 2009 Dec;27(12):2365-76 [19730394] Lancet. 2009 Nov 28;374(9704):1840-8 [19922995] BMJ. 2010;340:b5465 [20068258] Am J Cardiol. 2010 Jan 4;105(1 Suppl):21A-9A [20102970] J Hypertens. 2010 Mar;28(3):429 [20160578] Methods Mol Biol. 2010;633:233-9 [20204632] Curr Clin Pharmacol. 2010 May;5(2):89-95 [20156154] Rejuvenation Res. 2010 Apr-Jun;13(2-3):195-201 [20370487] Pflugers Arch. 2010 Jul;460(2):525-42 [20229265] Physiology (Bethesda). 2010 Jun;25(3):176-85 [20551231] Hypertens Res. 2010 Aug;33(8):831-5 [20505677] J Neurosurg. 2010 Sep;113(3):564-70 [20113156] Hypertens Res. 2010 Oct;33(10):1044-52 [20668453] Psychoneuroendocrinology. 2011 Jan;36(1):1-18 [21035950] Lancet Neurol. 2011 Jan;10(1):43-53 [20980201] Exp Neurol. 2011 Jan;227(1):128-35 [20965168] PLoS One. 2011;6(1):e16037 [21297982] Neuropsychopharmacology. 2011 Mar;36(4):857-70 [21150913] J Renin Angiotensin Aldosterone Syst. 2011 Mar;12(1):1-7 [20603272] J Alzheimers Dis. 2011;26(4):699-708 [21709373] J Hypertens. 2012 Jan;30(1):87-96 [22124178] Crit Care Med. 2012 Mar;40(3):935-44 [21926585] Cell Mol Neurobiol. 2012 Mar;32(2):191-200 [21822733] Hypertension. 2012 May;59(5):1079-88 [22454480] J Clin Pharm Ther. 2012 Jun;37(3):319-27 [21848583] Expert Opin Drug Saf. 2012 Jul;11(4):565-79 [22616948] Clin Sci (Lond). 2012 Nov;123(10):567-90 [22827472] J Neuroinflammation. 2012;9:102 [22642771] Curr HIV Res. 2012 Jul;10(5):392-406 [22591363] Neuropsychopharmacology. 2012 Dec;37(13):2817-29 [22892395] J Neuroinflammation. 2012;9:275 [23259598] Neurochem Int. 2013 Mar;62(4):468-77 [23357479] Br J Pharmacol. 2013 Jul;169(6):1404-16 [23647130] Pharmacol Rev. 2000 Sep;52(3):415-72 [10977869] J Int Med Res. 2000 Jul-Aug;28(4):149-67 [11014323] Stroke. 2000 Oct;31(10):2478-86 [11022082] Endocrinology. 2001 Sep;142(9):3880-9 [11517166] J Pharmacol Exp Ther. 2002 May;301(2):494-500 [11961048] J Neurotrauma. 2002 May;19(5):627-38 [12042097] Stroke. 2002 Sep;33(9):2297-303 [12215602] Physiol Genomics. 2002 Oct 2;11(1):21-30 [12361987] J Cereb Blood Flow Metab. 2003 Mar;23(3):371-80 [12621312] Cerebellum. 2002 Jan-Mar;1(1):41-55 [12879973] Biochem Biophys Res Commun. 2003 Aug 29;308(3):505-10 [12914779] J Clin Endocrinol Metab. 2003 Sep;88(9):4496-501 [12970329] J Neurosci. 2003 Sep 24;23(25):8692-700 [14507968] Eur J Clin Pharmacol. 2004 Feb;59(12):863-8 [14747881] Hypertension. 2004 May;43(5):993-1002 [15007034] Stroke. 2004 Jul;35(7):1726-31 [15143297] Biochem Biophys Res Commun. 1992 May 29;185(1):253-9 [1599461] Neuroreport. 1992 Oct;3(10):922-4 [1358253] Pharmacol Rev. 1993 Jun;45(2):205-51 [8372104] Science. 1993 Oct 29;262(5134):689-95 [7901908] Biochem Biophys Res Commun. 1993 Dec 15;197(2):440-9 [8267579] Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3521-5 [7724593] Brain Res. 1995 Dec 12;703(1-2):63-71 [8719616] Prostaglandins. 1997 Sep;54(3):601-24 [9373877] J Neuroendocrinol. 1998 Jan;10(1):67-72 [9510060] Cell Mol Neurobiol. 1999 Apr;19(2):277-88 [10081610] Crit Rev Neurobiol. 1999;13(1):45-82 [10223523] J Cereb Blood Flow Metab. 2005 Jul;25(7):878-86 [15729290] J Neurochem. 2005 Sep;94(5):1395-401 [15992368] Hypertension. 2006 Jul;48(1):141-8 [16769992] J Neurosci. 2006 Jul 12;26(28):7502-12 [16837598] Eur J Pharmacol. 2006 Dec 15;552(1-3):112-22 [17064684] Vascul Pharmacol. 2006 Sep;45(3):154-62 [16765099] Clin Sci (Lond). 2007 Jun;112(7):375-84 [17324119] J Clin Invest. 2007 Nov;117(11):3393-402 [17965777] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuropharm.2013.11.022 ER - TY - JOUR T1 - Mutant frequency in comparison to oxidative DNA damage induced by ochratoxin A in L5178Y tk+/- (3.7.2C) mouse lymphoma cells. AN - 1501836067; 24164384 AB - Ochratoxin A (OTA) is a naturally occurring mycotoxin that contaminates animal feed and human food. OTA is nephrotoxic, hepatotoxic, immunosuppressive and a potent renal carcinogen in rodents. In the present study, we evaluated the genotoxicity of OTA in L5178Y tk(+/-) (3.7.2C) mouse lymphoma cells using the microwell version of the mouse lymphoma gene mutation assay (MLA) and the comet assay modified to detect oxidative DNA damage. Cells were treated for 4 hours with 0, 5, 10, 25, 50 or 100 µM of OTA in the presence and absence of exogenous metabolic activation (S9). Benzo[a]pyrene (1 µg/mL) and 4-nitroquinoline-1-oxide (0.1 µg/mL) were used as positive control with and without S9, respectively. OTA treatment produced dose-dependent increases in cytotoxicity and tk mutant frequency, with significant increases in mutant frequency detected at concentrations ≥25 µM with and without S9. Similarly treated cells were used for the comet assay conducted with and without formamidopyrimidine-DNA glycosylase for the determination of oxidative DNA damage. OTA exposure resulted in a significant increase in both direct and oxidative DNA damage, with induction of oxidative damage being greater. The results indicate that OTA is mutagenic in mouse lymphoma assay; and that OTA-generated oxidative DNA damage is, at least partially, responsible for its mutagenicity in the assay. JF - Drug and chemical toxicology AU - Ali, Rahat AU - Guo, Xiaoqing AU - Lin, Haixia AU - Khan, Qaiser M AU - Ismail, Muhammad AU - Waheed, Usman AU - Ali, Tayyaba AU - Bhalli, Javed A AD - National Center for Toxicological Research, U.S. Food and Drug Administration , Jefferson, Arkansas , USA . Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 227 EP - 232 VL - 37 IS - 2 KW - Mutagens KW - 0 KW - Ochratoxins KW - ochratoxin A KW - 1779SX6LUY KW - Benzo(a)pyrene KW - 3417WMA06D KW - 4-Nitroquinoline-1-oxide KW - 56-57-5 KW - Index Medicus KW - Oxidation-Reduction KW - Mutation -- drug effects KW - Comet Assay KW - Animals KW - 4-Nitroquinoline-1-oxide -- toxicity KW - Dose-Response Relationship, Drug KW - Benzo(a)pyrene -- toxicity KW - Mice KW - Cell Line, Tumor KW - Ochratoxins -- toxicity KW - Ochratoxins -- administration & dosage KW - Mutagens -- toxicity KW - Mutagens -- administration & dosage KW - Lymphoma -- pathology KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1501836067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+chemical+toxicology&rft.atitle=Mutant+frequency+in+comparison+to+oxidative+DNA+damage+induced+by+ochratoxin+A+in+L5178Y+tk%2B%2F-+%283.7.2C%29+mouse+lymphoma+cells.&rft.au=Ali%2C+Rahat%3BGuo%2C+Xiaoqing%3BLin%2C+Haixia%3BKhan%2C+Qaiser+M%3BIsmail%2C+Muhammad%3BWaheed%2C+Usman%3BAli%2C+Tayyaba%3BBhalli%2C+Javed+A&rft.aulast=Ali&rft.aufirst=Rahat&rft.date=2014-04-01&rft.volume=37&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Drug+and+chemical+toxicology&rft.issn=1525-6014&rft_id=info:doi/10.3109%2F01480545.2013.838775 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-06 N1 - Date created - 2014-02-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.3109/01480545.2013.838775 ER - TY - JOUR T1 - Inhibition of monoamine oxidase (MAO) by β-carbolines and their interactions in live neuronal (PC12) and liver (HuH-7 and MH1C1) cells. AN - 1499116052; 24373881 AB - Interactions among monoamine oxidase (MAO) inhibitors in drugs, botanicals, and dietary supplements may lead to unpredictable neurochemical dysfunction due to excessive inhibition or therapeutic invalidation. Often recombinant MAO or brain tissue homogenates have been used to evaluate MAO inhibitors such as the β-carboline alkaloids (harmane, harmine, harmaline, and harmalol). However, there is a lack of cellular systems for evaluation of MAO activity, which represents a more advanced in vitro model compared to recombinant enzymes or tissue lysates. Using kynuramine assays, intracellular MAO inhibition by β-carbolines was measured in PC12 (rat pheochromocytoma), MH1C1 (rat liver), and HuH-7 (human liver) cell lines, which were compared with human recombinant MAO and cell lysates. β-Carbolines (1 μM, 90 min incubations) inhibited MAO by 40-99% in live PC12 cells where MAO A was the active isoform, and <12% in HuH-7 and MH1C1 cells where MAO B was primarily active. The combination index (CI), which serves as a quantitative indicator of pharmacological interactions, was determined for harmaline/harmine (CI, 1.01-1.25) and methylene blue/harmine (CI, 0.74-1.07) in PC12 cells. Overall, this study illustrates applications of cell-based in vitro assay platforms to gain a comprehensive understanding of intracellular MAO inhibitors and their interactions. Published by Elsevier Ltd. JF - Toxicology in vitro : an international journal published in association with BIBRA AU - Santillo, Michael F AU - Liu, Yitong AU - Ferguson, Martine AU - Vohra, Sanah N AU - Wiesenfeld, Paddy L AD - Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. Electronic address: michael.santillo@fda.hhs.gov. ; Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 8301 Muirkirk Rd, Laurel, MD 20708, USA. ; Division of Public Health and Biostatistics, Office of Analytics and Outreach, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Pkwy, College Park, MD 20740, USA. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 403 EP - 410 VL - 28 IS - 3 KW - Alkaloids KW - 0 KW - Carbolines KW - Monoamine Oxidase Inhibitors KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Index Medicus KW - Harmine KW - Cell assay KW - Harmaline KW - Methylene blue KW - Botanical KW - Combination index KW - Rats KW - Animals KW - Liver -- enzymology KW - Liver -- cytology KW - Liver -- drug effects KW - Humans KW - Alkaloids -- pharmacology KW - Cell Line, Tumor KW - Species Specificity KW - Cell Line KW - PC12 Cells KW - Monoamine Oxidase -- drug effects KW - Carbolines -- pharmacology KW - Monoamine Oxidase -- metabolism KW - Models, Biological KW - Monoamine Oxidase Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499116052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.atitle=Inhibition+of+monoamine+oxidase+%28MAO%29+by+%CE%B2-carbolines+and+their+interactions+in+live+neuronal+%28PC12%29+and+liver+%28HuH-7+and+MH1C1%29+cells.&rft.au=Santillo%2C+Michael+F%3BLiu%2C+Yitong%3BFerguson%2C+Martine%3BVohra%2C+Sanah+N%3BWiesenfeld%2C+Paddy+L&rft.aulast=Santillo&rft.aufirst=Michael&rft.date=2014-04-01&rft.volume=28&rft.issue=3&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Toxicology+in+vitro+%3A+an+international+journal+published+in+association+with+BIBRA&rft.issn=1879-3177&rft_id=info:doi/10.1016%2Fj.tiv.2013.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-26 N1 - Date created - 2014-02-05 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tiv.2013.12.006 ER - TY - JOUR T1 - High awareness of hepatitis c virus (HCV) but limited knowledge of HCV complications among HIV-positive and HIV-negative men who have sex with men AN - 1499082675; 4528527 AB - Hepatitis C virus (HCV) has emerged as a sexually transmitted infection among HIV-positive men who have sex with men (MSM) in high-income countries. Little is reported about HCV awareness among MSM, although this is essential for developing targeted prevention strategies. We, therefore, studied HCV awareness and knowledge among HIV-positive and HIV-negative MSM from the Amsterdam Cohort Studies (ACS). During two visits, 1 year apart and starting in October 2007, MSM from the ACS answered questions regarding HCV awareness, knowledge of HCV transmission (7 items), complications (8 items) and sexual risk behaviour. We examined the percentage of HCV awareness and correctly answered knowledge items, and whether awareness and knowledge improved significantly over time. Using logistic regression, we studied whether HIV status and sexual risk behaviour were associated with awareness. Seventy percent (312/444) of HIV-negative and 80% (74/92) of HIV-positive MSM reported to have ever heard of HCV on the first visit. Overall, awareness increased with 9% between the first and second visit (p < 0.001). In multivariate analysis the association of group sex with HCV awareness was borderline significant (OR 1.49, 95% CI 0.97-2.30). Compared with knowledge of transmission routes, knowledge of complications appeared to be limited. In the ACS, awareness of HCV is high, particularly among those reporting group sex, an important risk factor for HCV transmission. The majority of participants had good knowledge of transmission routes, but limited knowledge of complications of chronic HCV infection. HCV prevention messages could be strengthened, therefore, by further addressing the complications of HCV infection. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Lambers, Femke A.E. AU - Prins, Maria AU - Davidovich, Udi AU - Stolte, Ineke G AD - Public Health Service of Amsterdam Y1 - 2014/04// PY - 2014 DA - Apr 2014 SP - 416 EP - 424 VL - 26 IS - 4 SN - 0954-0121, 0954-0121 KW - Sociology KW - Hepatitis KW - Sexuality KW - Consciousness KW - Gender KW - HIV KW - Knowledge UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499082675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=High+awareness+of+hepatitis+c+virus+%28HCV%29+but+limited+knowledge+of+HCV+complications+among+HIV-positive+and+HIV-negative+men+who+have+sex+with+men&rft.au=Lambers%2C+Femke+A.E.%3BPrins%2C+Maria%3BDavidovich%2C+Udi%3BStolte%2C+Ineke+G&rft.aulast=Lambers&rft.aufirst=Femke&rft.date=2014-04-01&rft.volume=26&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540121.2013.832721 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2014-02-10 N1 - Last updated - 2014-02-18 N1 - SubjectsTermNotLitGenreText - 5703 3617 6220; 2724; 7073; 5421 6091; 11579 11538; 5810 3617 6220 DO - http://dx.doi.org/10.1080/09540121.2013.832721 ER - TY - JOUR T1 - Isolation and molecular characterization of Salmonella enterica serovar Enteritidis from poultry house and clinical samples during 2010. AN - 1464493534; 24290628 AB - A total of 60 Salmonella enterica serovar (ser.) Enteritidis isolates, 28 from poultry houses and 32 from clinical samples, were isolated during 2010. These isolates were subjected to testing and analyzed for antibiotic resistance, virulence genes, plasmids and plasmid replicon types. To assess genetic diversity, pulsed-field gel electrophoresis (PFGE) fingerprinting, using the XbaI restriction enzyme, Multiple-Locus Variable-Number Tandem Repeat Analysis (MLVA) and plasmid profiles were performed. All isolates from poultry, and 10 out of 32 clinical isolates were sensitive to ampicillin, chloramphenicol, gentamicin, kanamycin, nalidixic acid, sulfisoxazole, streptomycin, and tetracycline. Twenty-one of thirty-two clinical isolates were resistant to ampicillin and tetracycline, and one isolate was resistant to nalidixic acid. PFGE typing of sixty ser. Enteritidis isolates by XbaI resulted in 10-12 bands and grouped into six clusters each with similarity from 95% to 81%. The MLVA analysis of sixty isolates gave 18 allele profiles with the majority of isolates displayed in three groups, and two clinical isolates found to be new in the PulseNet national MLVA database. All isolates were positive for 12 or more of the 17 virulence genes mostly found in S. enterica (spvB, spiA, pagC, msgA, invA, sipB, prgH, spaN, orgA, tolC, iroN, sitC, IpfC, sifA, sopB, and pefA) and negative for one gene (cdtB). All isolates carried a typical 58 kb plasmid, type Inc/FIIA. Three poultry isolates and one clinical isolate carried small plasmids with 3.8, 6, 7.6 and 11.5 kb. Ten of the clinical isolates carried plasmids, with sizes 36 and 38 kb, types IncL/M and IncN, and one isolate carried an 81 kb plasmid, type IncI. Southern hybridization of a plasmid with an Inc/FIIA gene probe hybridized one large 58 kb plasmid in all isolates. Several large and small plasmids from poultry isolates were not typed by our PCR-based method. These results confirmed that PFGE fingerprinting has limited discriminatory power for ser. Enteritidis in both poultry and clinical sources. However, the plasmid and MLVA allele profiles were a useful and important epidemiology tool to discriminate outbreak strains of ser. Enteritidis from poultry and clinical samples. Published by Elsevier Ltd. JF - Food microbiology AU - Mezal, Ezat H AU - Sabol, Ashley AU - Khan, Mariam A AU - Ali, Nawab AU - Stefanova, Rossina AU - Khan, Ashraf A AD - Microbiology Division, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA; University of Arkansas at Little Rock, Little Rock, AR 72205, USA; University of Thi-Qar, Science of College, Biology of Dept., Thi-Qar, Iraq. Y1 - 2014/04// PY - 2014 DA - April 2014 SP - 67 EP - 74 VL - 38 KW - Anti-Bacterial Agents KW - 0 KW - Bacterial Proteins KW - Virulence Factors KW - Index Medicus KW - MLVA KW - Salmonella Enteritidis KW - Pulsed-field gel electrophoresis KW - Plasmid KW - Phylogeny KW - Animals KW - Poultry KW - Bacterial Proteins -- genetics KW - Humans KW - Anti-Bacterial Agents -- pharmacology KW - Virulence Factors -- genetics KW - Drug Resistance, Multiple, Bacterial KW - Microbial Sensitivity Tests KW - Salmonella Infections, Animal -- microbiology KW - Salmonella enteritidis -- drug effects KW - Poultry Diseases -- microbiology KW - Salmonella enteritidis -- classification KW - Salmonella Infections -- microbiology KW - Animal Husbandry -- instrumentation KW - Salmonella enteritidis -- genetics KW - Salmonella enteritidis -- isolation & purification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1464493534?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Food+microbiology&rft.atitle=Isolation+and+molecular+characterization+of+Salmonella+enterica+serovar+Enteritidis+from+poultry+house+and+clinical+samples+during+2010.&rft.au=Mezal%2C+Ezat+H%3BSabol%2C+Ashley%3BKhan%2C+Mariam+A%3BAli%2C+Nawab%3BStefanova%2C+Rossina%3BKhan%2C+Ashraf+A&rft.aulast=Mezal&rft.aufirst=Ezat&rft.date=2014-04-01&rft.volume=38&rft.issue=&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Food+microbiology&rft.issn=1095-9998&rft_id=info:doi/10.1016%2Fj.fm.2013.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-07-09 N1 - Date created - 2013-12-02 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.fm.2013.08.003 ER - TY - JOUR T1 - Estimating the effective density of engineered nanomaterials for in vitro dosimetry. AN - 1511396793; 24675174 AB - The need for accurate in vitro dosimetry remains a major obstacle to the development of cost-effective toxicological screening methods for engineered nanomaterials. An important key to accurate in vitro dosimetry is the characterization of sedimentation and diffusion rates of nanoparticles suspended in culture media, which largely depend upon the effective density and diameter of formed agglomerates in suspension. Here we present a rapid and inexpensive method for accurately measuring the effective density of nano-agglomerates in suspension. This novel method is based on the volume of the pellet obtained by benchtop centrifugation of nanomaterial suspensions in a packed cell volume tube, and is validated against gold-standard analytical ultracentrifugation data. This simple and cost-effective method allows nanotoxicologists to correctly model nanoparticle transport, and thus attain accurate dosimetry in cell culture systems, which will greatly advance the development of reliable and efficient methods for toxicological testing and investigation of nano-bio interactions in vitro. JF - Nature communications AU - DeLoid, Glen AU - Cohen, Joel M AU - Darrah, Tom AU - Derk, Raymond AU - Rojanasakul, Liying AU - Pyrgiotakis, Georgios AU - Wohlleben, Wendel AU - Demokritou, Philip AD - 1] Department of Environmental Health, Center for Nanotechnology and Nanotoxicology, Harvard School of Public Health, 655 Huntington Ave Boston, Massachusetts 02115, USA [2]. ; Division of Earth and Ocean Sciences, Nicholas School of the Environment, 207A Old Chemistry Building, Box 90227 Duke University, Durham, North Carolina 27708, USA. ; National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Pathology and Physiology Research Branch, Morgantown, West Virginia 26505, USA. ; Department of Environmental Health, Center for Nanotechnology and Nanotoxicology, Harvard School of Public Health, 655 Huntington Ave Boston, Massachusetts 02115, USA. ; BASF SE, GMC/R-G201, 67056 Ludwigshafen, Germany. Y1 - 2014/03/28/ PY - 2014 DA - 2014 Mar 28 SP - 3514 VL - 5 KW - Index Medicus KW - Particle Size KW - Humans KW - Diffusion KW - Ultracentrifugation KW - Cell Line KW - Nanostructures -- chemistry KW - Cells -- chemistry KW - Nanotechnology -- instrumentation KW - Nanotechnology -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1511396793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+communications&rft.atitle=Estimating+the+effective+density+of+engineered+nanomaterials+for+in+vitro+dosimetry.&rft.au=DeLoid%2C+Glen%3BCohen%2C+Joel+M%3BDarrah%2C+Tom%3BDerk%2C+Raymond%3BRojanasakul%2C+Liying%3BPyrgiotakis%2C+Georgios%3BWohlleben%2C+Wendel%3BDemokritou%2C+Philip&rft.aulast=DeLoid&rft.aufirst=Glen&rft.date=2014-03-28&rft.volume=5&rft.issue=&rft.spage=3514&rft.isbn=&rft.btitle=&rft.title=Nature+communications&rft.issn=2041-1723&rft_id=info:doi/10.1038%2Fncomms4514 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-22 N1 - Date created - 2014-03-28 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicology. 2012 Jul 16;297(1-3):1-9 [22487507] Part Fibre Toxicol. 2013;10:42 [23968360] Nanotoxicology. 2012 Sep;6(6):680-90 [21809902] J Control Release. 2012 Sep 10;162(2):259-66 [22824784] Nanotoxicology. 2013 Jun;7(4):417-31 [22393878] Biophys J. 2000 Mar;78(3):1606-19 [10692345] Water Res. 2005 May;39(9):1818-30 [15899280] Environ Sci Technol. 2005 Dec 1;39(23):9370-6 [16382966] Science. 2006 Feb 3;311(5761):622-7 [16456071] Biotechnol Bioeng. 2006 Dec 20;95(6):1228-33 [16865737] Toxicol Sci. 2007 Feb;95(2):300-12 [17098817] Toxicol Sci. 2008 Feb;101(2):239-53 [17872897] J Toxicol Environ Health A. 2010;73(5):445-61 [20155585] J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):51-138 [20574894] Nanotechnology. 2010 Jul 16;21(28):285103 [20562477] Environ Sci Technol. 2010 Oct 1;44(19):7309-14 [20536146] ACS Nano. 2010 Oct 26;4(10):5527-31 [20973573] Inhal Toxicol. 2010 Dec;22 Suppl 2:107-16 [20701428] Part Fibre Toxicol. 2010;7(1):36 [21118529] Metallomics. 2009 Nov;1(6):479-88 [21305156] Chem Res Toxicol. 2011 Feb 18;24(2):150-8 [21171596] ACS Nano. 2011 Feb 22;5(2):1223-35 [21250651] Nat Commun. 2011;2:335 [21654635] Nat Nanotechnol. 2011 Jun;6(6):385-91 [21516092] ACS Nano. 2011 Oct 25;5(10):8070-9 [21888410] Nanotoxicology. 2011 Dec;5(4):711-29 [21073401] Nanotoxicology. 2011 Dec;5(4):517-30 [21142841] Environ Health Perspect. 2011 Nov;119(11):1539-46 [21788197] Inorg Chem. 2011 Nov 21;50(22):11294-6 [22026434] Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Jan-Feb;4(1):1-15 [21965171] Environ Health Perspect. 2012 Jan;120(1):A13; author reply A13 [22214547] Inhal Toxicol. 2012;24(2):125-35 [22260506] Inhal Toxicol. 2013 Aug;25(9):498-508 [23895351] Nanotoxicology. 2013 Dec;7(8):1338-50 [23061914] ACS Nano. 2012 May 22;6(5):4349-68 [22502734] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1038/ncomms4514 ER - TY - CPAPER T1 - Regulatory Acceptance of Nontraditional Animal Models for Safety Assessment: US Perspective T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518614742; 6281620 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Jacobs, A Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Animal models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518614742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Regulatory+Acceptance+of+Nontraditional+Animal+Models+for+Safety+Assessment%3A+US+Perspective&rft.au=Jacobs%2C+A&rft.aulast=Jacobs&rft.aufirst=A&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Regulatory Expectations for Submission of Novel In Vitro Assays Addressing Cardiovascular Risk T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518613677; 6281552 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Papoian, T Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Health risks KW - Cardiovascular diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518613677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Regulatory+Expectations+for+Submission+of+Novel+In+Vitro+Assays+Addressing+Cardiovascular+Risk&rft.au=Papoian%2C+T&rft.aulast=Papoian&rft.aufirst=T&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - PET/CT Approaches to Imaging Aspects of Neurotoxicity in the Developing Animal T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518613645; 6281548 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Paule, M Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Computed tomography KW - Neurotoxicity KW - Positron emission tomography KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518613645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=PET%2FCT+Approaches+to+Imaging+Aspects+of+Neurotoxicity+in+the+Developing+Animal&rft.au=Paule%2C+M&rft.aulast=Paule&rft.aufirst=M&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Regulatory Authority Experience with Diverse Molecular Chemistries and Preclinical Safety Assessments Supporting First Time in Humans T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518613540; 6281578 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Jacobson Kram, D Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Stem cells KW - Toxicology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518613540?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Regulatory+Authority+Experience+with+Diverse+Molecular+Chemistries+and+Preclinical+Safety+Assessments+Supporting+First+Time+in+Humans&rft.au=Jacobson+Kram%2C+D&rft.aulast=Jacobson+Kram&rft.aufirst=D&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Preclinical Development of Neurotoxicity Biomarkers Using In Vivo MRI T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518613522; 6281481 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Liachenko, S Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Bioindicators KW - Magnetic resonance imaging KW - Neurotoxicity KW - Biomarkers KW - biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518613522?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Preclinical+Development+of+Neurotoxicity+Biomarkers+Using+In+Vivo+MRI&rft.au=Liachenko%2C+S&rft.aulast=Liachenko&rft.aufirst=S&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Indirect Xenobiotic Immune Modulation: Risk Assessment T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518613510; 6281465 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Myers, L Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Risk assessment KW - Xenobiotics KW - Immunomodulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518613510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Indirect+Xenobiotic+Immune+Modulation%3A+Risk+Assessment&rft.au=Myers%2C+L&rft.aulast=Myers&rft.aufirst=L&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Developing Cell Therapy Products: US FDA Preclinical Regulatory Considerations T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518613405; 6281471 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Au, P. Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Therapy KW - FDA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518613405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Developing+Cell+Therapy+Products%3A+US+FDA+Preclinical+Regulatory+Considerations&rft.au=Au%2C+P.&rft.aulast=Au&rft.aufirst=P.&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Moving Innovation into Regulatory Reality T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518613390; 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6281527 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Snawder, J Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Upstream KW - Oil and gas production UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518613132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=NIOSH+Exposure+Assessment+of+Upstream+Oil+and+Gas+Production&rft.au=Snawder%2C+J&rft.aulast=Snawder&rft.aufirst=J&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Safety Considerations for the Use of Nanomaterials in Food and Food-Related Products: A US FDA Regulatory Perspective T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518611817; 6281447 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Thurmond, S Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Food KW - FDA KW - nanotechnology KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518611817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Safety+Considerations+for+the+Use+of+Nanomaterials+in+Food+and+Food-Related+Products%3A+A+US+FDA+Regulatory+Perspective&rft.au=Thurmond%2C+S&rft.aulast=Thurmond&rft.aufirst=S&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Overcoming Obstacles to Study Drug-Induced Liver Injury with Toxicogenomics towards a Regulatory Application T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518611753; 6281521 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Tong, W Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Injuries KW - Liver KW - Animal physiology KW - Toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518611753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Overcoming+Obstacles+to+Study+Drug-Induced+Liver+Injury+with+Toxicogenomics+towards+a+Regulatory+Application&rft.au=Tong%2C+W&rft.aulast=Tong&rft.aufirst=W&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Strategies for Developing miRNA Biomarkers of Toxicity T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609542; 6281253 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Thompson, K Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Bioindicators KW - miRNA KW - Biomarkers KW - Toxicity KW - biomarkers UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Strategies+for+Developing+miRNA+Biomarkers+of+Toxicity&rft.au=Thompson%2C+K&rft.aulast=Thompson&rft.aufirst=K&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Inhalation Exposure Methodologies for Manufactured Nanomaterials T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609486; 6281289 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Chen, B Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Inhalation KW - nanotechnology KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Inhalation+Exposure+Methodologies+for+Manufactured+Nanomaterials&rft.au=Chen%2C+B&rft.aulast=Chen&rft.aufirst=B&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Carbon Nanotube Exposure Assessment: An Evaluation of Workplace Exposures in the US T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609474; 6281313 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Dahm, M AU - Schubauer-Berigan, M AU - Erdely, A Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Carbon KW - Occupational exposure KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Carbon+Nanotube+Exposure+Assessment%3A+An+Evaluation+of+Workplace+Exposures+in+the+US&rft.au=Dahm%2C+M%3BSchubauer-Berigan%2C+M%3BErdely%2C+A&rft.aulast=Dahm&rft.aufirst=M&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Overview of Combination Products T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609462; 6281245 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Nguyen, T Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609462?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Overview+of+Combination+Products&rft.au=Nguyen%2C+T&rft.aulast=Nguyen&rft.aufirst=T&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Relationship between In Vivo Carcinogenicity and Human Risk to Carbon Nanotubes T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609450; 6281314 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Sargent, L AU - Porter, D AU - Staska, L AU - Hubbs, A AU - Kashon, M AU - Lowry, D AU - Battelli, L AU - Chen, B AU - Frazer, D AU - Castranova, V AU - Reynolds, S Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Carbon KW - Carcinogenicity KW - nanotubes KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Relationship+between+In+Vivo+Carcinogenicity+and+Human+Risk+to+Carbon+Nanotubes&rft.au=Sargent%2C+L%3BPorter%2C+D%3BStaska%2C+L%3BHubbs%2C+A%3BKashon%2C+M%3BLowry%2C+D%3BBattelli%2C+L%3BChen%2C+B%3BFrazer%2C+D%3BCastranova%2C+V%3BReynolds%2C+S&rft.aulast=Sargent&rft.aufirst=L&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - FDA Regulatory Perspective on Pediatric Product Development T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609440; 6281292 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Davis-Bruno, K Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Pediatrics KW - FDA KW - Product development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=FDA+Regulatory+Perspective+on+Pediatric+Product+Development&rft.au=Davis-Bruno%2C+K&rft.aulast=Davis-Bruno&rft.aufirst=K&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Applying Databases and Tools from COSMOS to the Scientific Needs of US FDA's CERES Project T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609432; 6281321 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Arvidson, K Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Databases KW - FDA KW - Cosmos UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609432?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Applying+Databases+and+Tools+from+COSMOS+to+the+Scientific+Needs+of+US+FDA%27s+CERES+Project&rft.au=Arvidson%2C+K&rft.aulast=Arvidson&rft.aufirst=K&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Carbon Nanotubes Are Toxic in Experimental Models: What's Next, Who's Being Exposed, and Should We Be Concerned? T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609382; 6281311 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Erdely, A AU - Antonini, J Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Carbon KW - nanotubes KW - Models KW - Nanotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609382?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Carbon+Nanotubes+Are+Toxic+in+Experimental+Models%3A+What%27s+Next%2C+Who%27s+Being+Exposed%2C+and+Should+We+Be+Concerned%3F&rft.au=Erdely%2C+A%3BAntonini%2C+J&rft.aulast=Erdely&rft.aufirst=A&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Regulatory Overview of Preclinical Assessment of Combination Products T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609364; 6281247 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Ghosh, C Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Regulatory+Overview+of+Preclinical+Assessment+of+Combination+Products&rft.au=Ghosh%2C+C&rft.aulast=Ghosh&rft.aufirst=C&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Background on miRNA Biology and Relationship to Toxicology T2 - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AN - 1518609342; 6281249 JF - 53rd Annual Meeting of the Society of Toxicology (SOT 2014) AU - Pogribny, I Y1 - 2014/03/23/ PY - 2014 DA - 2014 Mar 23 KW - miRNA KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518609342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.atitle=Background+on+miRNA+Biology+and+Relationship+to+Toxicology&rft.au=Pogribny%2C+I&rft.aulast=Pogribny&rft.aufirst=I&rft.date=2014-03-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=53rd+Annual+Meeting+of+the+Society+of+Toxicology+%28SOT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.toxicology.org/AI/Pub/Prog/2014Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - RPRT T1 - NATIONAL INSTITUTES OF HEALTH BETHESDA CAMPUS PROPOSED 2013 MASTER PLAN, MONTGOMERY COUNTY, MARYLAND. AN - 16381449; 16075 AB - PURPOSE: The National Institutes of Health (NIH) is prepared a 20-year Master Plan for the NIH Bethesda Campus, which provides a planning framework for siting and development of facilities. The NIH Bethesda campus is a 310-acre federal government facility located in Montgomery County, Maryland, in the Washington, DC metropolitan area. The 2013 Bethesda Master Plan identifies one plan as the Proposed Action. Two alternative actions are reviewed. The Proposed Action renovates eight existing buildings, repurposing former research areas into administrative functions. Five new research buildings and three new administrative buildings are planned, as well as ten support buildings, three new parking garages and the necessary infrastructure for the redevelopment. Under the Proposed Action, approximately 20 outdated buildings and service structures are scheduled for demolition, providing building sites for redevelopment of the proposed new facilities. The Proposed Action is scheduled for a 20-year period, phased to allow organized relocations, renovations, demolition, and redevelopment to occur gradually to reduce the construction impact at any one time. The No Action alternative includes no net growth or change in employee numbers of facilities in relation to baseline or existing conditions. The Maximum Development alternative assumes that laboratories constructed during the mid-20th century on the NIH Bethesda Campus would be replaced with new state of the art laboratories. Current older research buildings that can be adapted to new uses such as office space, physician offices, space for instruments, or systems biology are to be re-purposed. POSITIVE IMPACTS: The proposed development meets the need to replace aging and inadequate infrastructure and buildings that compromise the NIH goals and mission. The development also allows consolidation of dispersed operational spaces from off-campus locations. NEGATIVE IMPACTS: Potential impacts to the soils and groundwater can be expected with the significant amount of earthwork and soil disruption projected in the Proposed Action and Maximum Development alternative. Based on the proposed alternative plans, increases in energy usage are proposed to increase by approximately 20 percent under the Proposed Action and by 40 percent under the Maximum Development alternative. The Proposed Action would increase the amount of wastewater generated on campus with the proposal of additional development. JF - EPA number: 140079, Draft EIS--408 pages, March 21, 2014 PY - 2014 KW - Urban and Social Programs KW - Buildings KW - Land Use KW - Parking KW - Research KW - Research Facilities KW - Employment KW - Waste Management KW - Sewers KW - Demolition KW - Soils KW - Water Quality KW - Water Resources KW - Site Planning KW - Maryland KW - Executive Order 13327, Compliance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/16381449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2014-03-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CAMPUS+PROPOSED+2013+MASTER+PLAN%2C+MONTGOMERY+COUNTY%2C+MARYLAND.&rft.title=NATIONAL+INSTITUTES+OF+HEALTH+BETHESDA+CAMPUS+PROPOSED+2013+MASTER+PLAN%2C+MONTGOMERY+COUNTY%2C+MARYLAND.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland; HHS N1 - Date revised - 2014-10-01 N1 - SuppNotes - Draft. Preparation date: March 21, 2014 N1 - Last updated - 2014-10-31 ER - TY - JOUR T1 - Circulating extracellular vesicles as a potential source of new biomarkers of drug-induced liver injury. AN - 1513048233; 24462978 AB - Like most cell types, hepatocytes constantly produce extracellular vesicles (EVs) such as exosomes and microvesicles that are released into the circulation to transport signaling molecules and cellular waste. Circulating EVs are being vigorously explored as biomarkers of diseases and toxicities, including drug-induced liver injury (DILI). Emerging data suggest that (a) blood-borne EVs contain liver-specific mRNAs and microRNAs (miRNAs), (b) the levels can be remarkably elevated in response to DILI, and (c) the increases correlate well with classical measures of liver damage. The expression profile of mRNAs in EVs and the compartmentalization of miRNAs within EVs or other blood fractions were found to be indicative of the offending drug involved in DILI, thus providing more informative assessment of liver injury than using alanine aminotransferase alone. EVs in the urine and cell culture medium were also found to contain proteins or mRNAs that were indicative of DILI. However, major improvements in EV isolation methods are needed for the discovery, evaluation, and quantification of possible DILI biomarkers in circulating EVs. Published by Elsevier Ireland Ltd. JF - Toxicology letters AU - Yang, Xi AU - Weng, Zuquan AU - Mendrick, Donna L AU - Shi, Qiang AD - Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. ; Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA. Electronic address: Qiang.Shi@fda.hhs.gov. Y1 - 2014/03/21/ PY - 2014 DA - 2014 Mar 21 SP - 401 EP - 406 VL - 225 IS - 3 KW - Biomarkers KW - 0 KW - MicroRNAs KW - RNA, Messenger KW - Index Medicus KW - Extracellular vesicles KW - Exosomes KW - Drug-induced liver injury KW - MicroRNAs -- genetics KW - Humans KW - Biomarkers -- urine KW - RNA, Messenger -- genetics KW - Biomarkers -- blood KW - Hepatocytes -- metabolism KW - Chemical and Drug Induced Liver Injury -- blood KW - Exosomes -- metabolism KW - Exosomes -- genetics KW - Chemical and Drug Induced Liver Injury -- genetics KW - Chemical and Drug Induced Liver Injury -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1513048233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+letters&rft.atitle=Circulating+extracellular+vesicles+as+a+potential+source+of+new+biomarkers+of+drug-induced+liver+injury.&rft.au=Yang%2C+Xi%3BWeng%2C+Zuquan%3BMendrick%2C+Donna+L%3BShi%2C+Qiang&rft.aulast=Yang&rft.aufirst=Xi&rft.date=2014-03-21&rft.volume=225&rft.issue=3&rft.spage=401&rft.isbn=&rft.btitle=&rft.title=Toxicology+letters&rft.issn=1879-3169&rft_id=info:doi/10.1016%2Fj.toxlet.2014.01.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-05-21 N1 - Date created - 2014-02-24 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.toxlet.2014.01.013 ER - TY - CPAPER T1 - The Use of Quantitative Clinical Pharmacology to Guide Orphan Drug Development: A Regulatory Perspective T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518614296; 6284124 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Krudys, Kevin Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Pharmacology KW - Drug development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518614296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=The+Use+of+Quantitative+Clinical+Pharmacology+to+Guide+Orphan+Drug+Development%3A+A+Regulatory+Perspective&rft.au=Krudys%2C+Kevin&rft.aulast=Krudys&rft.aufirst=Kevin&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Ontological Framework for Systems Analysis of TKI Cardiotoxicity: Extension of the Ontology of Adverse Events (OAE) T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518614202; 6284112 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Sarntivijai, Sirarat Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Systems analysis KW - Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518614202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Ontological+Framework+for+Systems+Analysis+of+TKI+Cardiotoxicity%3A+Extension+of+the+Ontology+of+Adverse+Events+%28OAE%29&rft.au=Sarntivijai%2C+Sirarat&rft.aulast=Sarntivijai&rft.aufirst=Sirarat&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Regulatory Perspective on the Clinical Pharmacology Characterization of Oral Targeted Anticancer Drugs T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518614128; 6284099 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Rahman, Nam Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Pharmacology KW - Antitumor agents KW - Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518614128?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Regulatory+Perspective+on+the+Clinical+Pharmacology+Characterization+of+Oral+Targeted+Anticancer+Drugs&rft.au=Rahman%2C+Nam&rft.aulast=Rahman&rft.aufirst=Nam&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Clinical Significance of Drug Transporters in Pharmacokinetics, Efficacy and Toxicity T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518614111; 6284105 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Huang, Shiew-Mei Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Toxicity KW - Drugs KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518614111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Clinical+Significance+of+Drug+Transporters+in+Pharmacokinetics%2C+Efficacy+and+Toxicity&rft.au=Huang%2C+Shiew-Mei&rft.aulast=Huang&rft.aufirst=Shiew-Mei&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Discuss Regulatory Expectations for Pharmacometrics Support of Dose Optimization of Targeted Oncology Agents T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518614106; 6284118 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Mehrotra, Nitin Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518614106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Discuss+Regulatory+Expectations+for+Pharmacometrics+Support+of+Dose+Optimization+of+Targeted+Oncology+Agents&rft.au=Mehrotra%2C+Nitin&rft.aulast=Mehrotra&rft.aufirst=Nitin&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Ethics and Regulatory Aspects of Fetal Therapy: Unique Problems Facing Clinical Studies in Fetal Pharmacology T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518614066; 6284203 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Burckart, Gilbert Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Pharmacology KW - Ethics KW - Therapy KW - Fetuses UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518614066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Ethics+and+Regulatory+Aspects+of+Fetal+Therapy%3A+Unique+Problems+Facing+Clinical+Studies+in+Fetal+Pharmacology&rft.au=Burckart%2C+Gilbert&rft.aulast=Burckart&rft.aufirst=Gilbert&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Application of the FDA PBPK Knowledgebase in Evaluating Model Predictability for Drug-Drug Interactions T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518614062; 6284200 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Pan, Yuzhuo Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Drug interaction KW - FDA KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518614062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Application+of+the+FDA+PBPK+Knowledgebase+in+Evaluating+Model+Predictability+for+Drug-Drug+Interactions&rft.au=Pan%2C+Yuzhuo&rft.aulast=Pan&rft.aufirst=Yuzhuo&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - PBPK Models of Renally Eliminated Drugs and Their Application in Evaluating the Effect of Patient Factors T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518612989; 6284145 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Hsu, Vicky Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Drugs KW - Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518612989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=PBPK+Models+of+Renally+Eliminated+Drugs+and+Their+Application+in+Evaluating+the+Effect+of+Patient+Factors&rft.au=Hsu%2C+Vicky&rft.aulast=Hsu&rft.aufirst=Vicky&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Discuss Regulatory Expectations for Clinical Pharmacology Support of Dose Optimization of Targeted Oncology Agents T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518612972; 6284117 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Shord, Stacy Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Pharmacology KW - Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518612972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Discuss+Regulatory+Expectations+for+Clinical+Pharmacology+Support+of+Dose+Optimization+of+Targeted+Oncology+Agents&rft.au=Shord%2C+Stacy&rft.aulast=Shord&rft.aufirst=Stacy&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Perspective on Pediatric Development and Use of PBPK T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518612830; 6284173 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Zhao, Ping Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Pediatrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518612830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Perspective+on+Pediatric+Development+and+Use+of+PBPK&rft.au=Zhao%2C+Ping&rft.aulast=Zhao&rft.aufirst=Ping&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Identification of Panel of Blood Biomarkers in Rats for Prediction of Acute and Idiosyncratic Hepatotoxicity T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518612674; 6284210 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Beger, Richard Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Rats KW - Bioindicators KW - Prediction KW - Blood KW - Biomarkers KW - biomarkers KW - Hepatotoxicity KW - hepatotoxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518612674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Identification+of+Panel+of+Blood+Biomarkers+in+Rats+for+Prediction+of+Acute+and+Idiosyncratic+Hepatotoxicity&rft.au=Beger%2C+Richard&rft.aulast=Beger&rft.aufirst=Richard&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Predicting Adverse Events Based Upon a Drug's Molecular Target Profile T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518612492; 6284155 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Abernethy, Darrell Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Side effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518612492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=Predicting+Adverse+Events+Based+Upon+a+Drug%27s+Molecular+Target+Profile&rft.au=Abernethy%2C+Darrell&rft.aulast=Abernethy&rft.aufirst=Darrell&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - PK and PD Assessments of Hormonal Contraceptive Drug- Drug Interactions T2 - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AN - 1518612465; 6284130 JF - 115th American Society for Clinical Pharmacology and Therapeutics (ASCPT 2014) AU - Yu, Chongwoo Y1 - 2014/03/18/ PY - 2014 DA - 2014 Mar 18 KW - Drug interaction KW - Contraceptives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518612465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.atitle=PK+and+PD+Assessments+of+Hormonal+Contraceptive+Drug-+Drug+Interactions&rft.au=Yu%2C+Chongwoo&rft.aulast=Yu&rft.aufirst=Chongwoo&rft.date=2014-03-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=115th+American+Society+for+Clinical+Pharmacology+and+Therapeutics+%28ASCPT+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascpt.org/Portals/8/docs/Meetings/2014%20Annual%20Meeting/Final%20Program%20Proof%204.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - JOUR T1 - An electrochemiluminescence assay for the detection of bio threat agents in selected food matrices and in the screening of Clostridium botulinum outbreak strains associated with type A botulism. AN - 1499152446; 23873138 AB - Specific screening methods for complex food matrices are needed that enable unambiguous and sensitive detection of bio threat agents (BTAs) such as Bacillus anthracis spores and microbial toxins (e.g. staphylococcal enterotoxin B (SEB) and clostridial botulinum neurotoxins (BoNTs)). The present study describes an image-based 96-well Meso Scale Discovery (MSD) electrochemiluminescence (ECL) assay for simultaneous detection of BTAs in dairy milk products. The limit of detection of this ECL assay is 40 pg mL⁻¹ for BoNT/A complex, 10 pg mL⁻¹ for SEB and 40000 CFU mL⁻¹ for Bacillus anthracis spores in dairy milk products. The ECL assay was successfully applied to screen type A Clostridium botulinum outbreak strains. The results of the study indicate that this ECL assay is very sensitive, rapid (<6 h) and multiplex in nature. The ECL assay has potential for use as an in vitro screening method for BTAs over other comparable immunoassays. © 2013 Society of Chemical Industry. JF - Journal of the science of food and agriculture AU - Sachdeva, Amita AU - Singh, Ajay K AU - Sharma, Shashi K AD - Division of Microbiology, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD, 20740, USA. Y1 - 2014/03/15/ PY - 2014 DA - 2014 Mar 15 SP - 707 EP - 712 VL - 94 IS - 4 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Enterotoxins KW - anthrax toxin KW - enterotoxin B, staphylococcal KW - 39424-53-8 KW - Botulinum Toxins, Type A KW - EC 3.4.24.69 KW - Index Medicus KW - electrochemiluminescene KW - spores KW - bio threat agents KW - Clostridium botulinum KW - staphylococcal enterotoxin B KW - botulism KW - Bacillus anthracis KW - botulinum neurotoxins KW - Bacillus anthracis -- isolation & purification KW - United States KW - Enterotoxins -- chemistry KW - Botulism -- prevention & control KW - Enterotoxins -- metabolism KW - Humans KW - Bacillus anthracis -- physiology KW - Botulinum Toxins, Type A -- chemistry KW - Bacillus anthracis -- growth & development KW - Food Microbiology KW - Botulinum Toxins, Type A -- metabolism KW - Antigens, Bacterial -- chemistry KW - Spores, Bacterial -- isolation & purification KW - Antigens, Bacterial -- metabolism KW - Disease Outbreaks -- prevention & control KW - Antigens, Bacterial -- analysis KW - Enterotoxins -- analysis KW - Botulinum Toxins, Type A -- analysis KW - United States Food and Drug Administration KW - Botulism -- microbiology KW - Luminescent Measurements KW - Colony Count, Microbial KW - Botulism -- epidemiology KW - Limit of Detection KW - Electrochemical Techniques KW - Foodborne Diseases -- microbiology KW - Clostridium botulinum type A -- isolation & purification KW - Dairy Products -- analysis KW - Foodborne Diseases -- prevention & control KW - Dairy Products -- adverse effects KW - Bacterial Toxins -- metabolism KW - Dairy Products -- microbiology KW - Bacterial Toxins -- analysis KW - Foodborne Diseases -- etiology KW - Clostridium botulinum type A -- growth & development KW - Food Contamination KW - Bacterial Toxins -- chemistry KW - Food Inspection -- methods KW - Luminescence KW - Clostridium botulinum type A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499152446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+science+of+food+and+agriculture&rft.atitle=An+electrochemiluminescence+assay+for+the+detection+of+bio+threat+agents+in+selected+food+matrices+and+in+the+screening+of+Clostridium+botulinum+outbreak+strains+associated+with+type+A+botulism.&rft.au=Sachdeva%2C+Amita%3BSingh%2C+Ajay+K%3BSharma%2C+Shashi+K&rft.aulast=Sachdeva&rft.aufirst=Amita&rft.date=2014-03-15&rft.volume=94&rft.issue=4&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+science+of+food+and+agriculture&rft.issn=1097-0010&rft_id=info:doi/10.1002%2Fjsfa.6310 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-28 N1 - Date created - 2014-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1002/jsfa.6310 ER - TY - RPRT T1 - Implications of QRIS Design for the Distribution of Program Ratings and Linkages between Ratings and Observed Quality. OPRE Research Brief 2014-33 AN - 1826540792; ED566252 AB - This Brief compares three hypothetical Quality Rating and Improvement Systems (QRIS) that use different rating structures: block, points, and hybrid. Because the quality standards in the hypothetical QRIS are held relatively constant across structures, analyses can be conducted to determine how structure relates to key QRIS outcomes. Three outcomes are examined: the distribution of programs across ratings levels, the linkages of ratings with measures of observed quality, and the scores of individual quality components within each structure. Findings indicate that the distribution of ratings is significantly related to structure. Whereas fewer than one-fifth of programs achieved a Level 3 or 4 in the block structure, over 70% of programs achieved a Level 3 or 4 in the points and hybrid structures. Rating levels produced by each of the three structures were significantly correlated with observed quality as measured by the Early Childhood Environment Rating Scale--Revised (ECERS-R). However, the points structure was the only structure to produce quality levels in which observed quality was significantly different between each level. The points structure also captured the greatest range of ECERS-R scores with a 1.61 point spread between Level 1 and Level 4 compared to 0.13 and 1.14 point spreads for the block and hybrid structures respectively. Scores across rating levels in the rating structures showed different patterns for specific quality components, with some domains (Health and Safety, Assessment and Accreditation) scoring high regardless of level and structure, others (Family Partnerships) scoring relatively low and others (Teacher Qualifications and Director Qualifications) demonstrating how quality component scores can differ across structures. The analyses are limited in their application to QRIS because the data were collected with a unique sample and were not collected in the context of a "real" QRIS. Nevertheless, this Brief offers research evidence that can be useful to QRIS administrators as they weigh different design options and their potential consequences. AU - Tout, Kathryn AU - Chien, Nina AU - Rothenberg, Laura AU - Li, Weilin Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 18 PB - Administration for Children & Families. US Department of Health and Human Services, 370 L'Enfant Promenade SW, Washington, DC 20447. KW - Early Childhood Environment Rating Scale KW - ERIC, Resources in Education (RIE) KW - Early Childhood Education KW - Comparative Analysis KW - Rating Scales KW - Scores KW - Child Care KW - Correlation KW - Statistical Distributions KW - Educational Quality KW - Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1826540792?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Intelligent Machine Guard Monitoringing: A Wireless System to Improve Miner Safety AN - 1671543249; 19303977 AB - Researchers at the National Institute for Occupational Safety and Health (NIOSH) are developing an intelligent machine guard monitoring and proximity detection system designed to mitigate machine entanglement and maintenance-related injuries and fatalities prevalent in the mining industry. This experiment was designed to develop a monitoring system consisting of mechanical/magnetic switches and sensor beacons capable of wirelessly transmitting information about a belt conveyor's machine guards to a remote computer. The data transfer was carried out via an off-the-shelf wireless communication system and displayed on a Web-based user interface. Successful operational tests demonstrated the functionality and effectiveness of the system in monitoring guard placement status and remotely identifying the location of any removed guards using each sensor's unique identification number. The integration of wireless safety technologies such as this system is expected to improve the safety of miners by providing additional protections against machine guardingrelated injuries. JF - IEEE Industry Applications Magazine AU - Reyes, Miguel Angel AU - King, Grant W AU - Miller, Gregory G AD - Electrical & Mechanical System Safety Branch, NIOSH, Pittsburgh, Pennsylvania 15236 USA Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 69 EP - 75 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 United States VL - 20 IS - 2 SN - 1077-2618, 1077-2618 KW - Mechanical & Transportation Engineering Abstracts (MT); Environmental Engineering Abstracts (EN); Electronics and Communications Abstracts (EA) KW - Machine guards KW - Sensors KW - Injuries KW - Entanglement KW - Safety KW - Miners KW - Guards KW - Monitoring UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1671543249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Industry+Applications+Magazine&rft.atitle=Intelligent+Machine+Guard+Monitoringing%3A+A+Wireless+System+to+Improve+Miner+Safety&rft.au=Reyes%2C+Miguel+Angel%3BKing%2C+Grant+W%3BMiller%2C+Gregory+G&rft.aulast=Reyes&rft.aufirst=Miguel&rft.date=2014-03-01&rft.volume=20&rft.issue=2&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=IEEE+Industry+Applications+Magazine&rft.issn=10772618&rft_id=info:doi/10.1109%2FMIAS.2013.2288400 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2015-04-09 DO - http://dx.doi.org/10.1109/MIAS.2013.2288400 ER - TY - JOUR T1 - Auditory risk estimates for youth target shooting AN - 1665164157 AB - Objective: To characterize the impulse noise exposure and auditory risk for youth recreational firearm users engaged in outdoor target shooting events. The youth shooting positions are typically standing or sitting at a table, which places the firearm closer to the ground or reflective surface when compared to adult shooters. Design: Acoustic characteristics were examined and the auditory risk estimates were evaluated using contemporary damage-risk criteria for unprotected adult listeners and the 120-dB peak limit suggested by the World Health Organization (1999) for children. Study sample: Impulses were generated by 26 firearm/ammunition configurations representing rifles, shotguns, and pistols used by youth. Measurements were obtained relative to a youth shooterʼs left ear. Results: All firearms generated peak levels that exceeded the 120 dB peak limit suggested by the WHO for children. In general, shooting from the seated position over a tabletop increases the peak levels, L Aeq8 and reduces the unprotected maximum permissible exposures (MPEs) for both rifles and pistols. Pistols pose the greatest auditory risk when fired over a tabletop. Conclusion: Youth should utilize smaller caliber weapons, preferably from the standing position, and always wear hearing protection whenever engaging in shooting activities to reduce the risk for auditory damage. JF - International Journal of Audiology AU - Murphy, William J AU - Finan, Donald S AU - Lankford, James E AU - Flamme, Gregory A AU - Stewart, Michael AU - Soendergaard, Jacob AU - Jerome, Trevor W AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, USA ; Audiology and Speech-Language Sciences, University of Northern Colorado,Greeley, USA ; Allied Health and Communication Disorders, Northern Illinois University, DeKalb, USA ; Department of Speech Pathology and Audiology, Western Michigan University, Kalamazoo, USA ; Department of Communication Disorders, Central Michigan University, Mount Pleasant, USA ; G.R.A.S. Sound & Vibration, Twinsburg, USA ; Meinke, Deanna K; Audiology and Speech-Language Sciences, University of Northern Colorado, Campus Box 140, Greeley, CO 80639, USA Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - S16 EP - S25 CY - Hamilton PB - Taylor & Francis Ltd. VL - 53 IS - S2 SN - 1499-2027 KW - Medical Sciences--Otorhinolaryngology KW - Firearms KW - youth KW - recreational shooting KW - noise-induced hearing loss KW - auditory risk KW - impulse noise KW - Children KW - Young people KW - Hearing KW - Listeners KW - Noise KW - Noise exposure KW - Risk reduction KW - Shooting KW - Small arms KW - Weapons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665164157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Auditory+risk+estimates+for+youth+target+shooting&rft.au=Meinke%2C+Deanna+K%3BMurphy%2C+William+J%3BFinan%2C+Donald+S%3BLankford%2C+James+E%3BFlamme%2C+Gregory+A%3BStewart%2C+Michael%3BSoendergaard%2C+Jacob%3BJerome%2C+Trevor+W&rft.aulast=Meinke&rft.aufirst=Deanna&rft.date=2014-03-01&rft.volume=53&rft.issue=S2&rft.spage=S16&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2013.865845 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Name - World Health Organization N1 - Date revised - 2015-09-22 N1 - Last updated - 2016-05-13 DO - http://dx.doi.org/10.3109/14992027.2013.865845 ER - TY - JOUR T1 - Interventions to prevent occupational noise-induced hearing loss: A Cochrane systematic review AN - 1665162054 AB - Objective: To assess the effectiveness of interventions for preventing occupational noise exposure or hearing loss compared to no intervention or alternative interventions. Design: We searched biomedical databases up to 25 January 2012 for randomized controlled trials (RCT), controlled before-after studies and interrupted time-series of hearing loss prevention among workers exposed to noise. Study sample: We included 19 studies with 82 794 participants evaluating effects of hearing loss prevention programs (HLPP). The overall quality of studies was low to very low, as rated using the GRADE approach. Results: One study of stricter legislation showed a favorable effect on noise levels. Three studies, of which two RCTs, did not find an effect of a HLPP. Four studies showed that better use of hearing protection devices in HLPPs decreased the risk of hearing loss. In four other studies, workers in a HLPP still had a 0.5 dB greater hearing loss at 4 kHz (95% CI-0.5 to 1.7) than non-exposed workers. In two similar studies there was a substantial risk of hearing loss in spite of a HLPP. Conclusions: Stricter enforcement of legislation and better implementation of HLPPs can reduce noise levels in workplaces. Better evaluations of technical interventions and long-term effects are needed. JF - International Journal of Audiology AU - Kateman, Erik AU - Morata, Thais C AU - Dreschler, Wouter A AU - Mischke, Christina AD - Aspen, Oss, Netherlands ; National Institute for Occupational Safety and Health (NIOSH), Cincinnati, USA ; Clinical & Experimental Audiology, Academic Medical Centre, Amsterdam, Netherlands ; Cochrane Occupational Safety and Health Review Group, Finnish Institute of Occupational Health, Kuopio, Finland ; Verbeek, Jos H; Cochrane Occupational Safety and Health Review Group, Finnish Institute of Occupational Health, PO Box 310, 70101 Kuopio, Finland Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - S84 EP - S96 CY - Hamilton PB - Taylor & Francis Ltd. VL - 53 IS - S2 SN - 1499-2027 KW - Medical Sciences--Otorhinolaryngology KW - Noise KW - hearing conservation KW - demographics/epidemiology KW - behavioral measures KW - Databases KW - Preventive programmes KW - Randomized controlled trials KW - Workplaces KW - Enforcement KW - Hearing KW - Hearing impairment KW - Interventions KW - Legislation KW - Long term effects KW - Noise exposure KW - Occupational noise KW - Systematic reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665162054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Interventions+to+prevent+occupational+noise-induced+hearing+loss%3A+A+Cochrane+systematic+review&rft.au=Verbeek%2C+Jos+H%3BKateman%2C+Erik%3BMorata%2C+Thais+C%3BDreschler%2C+Wouter+A%3BMischke%2C+Christina&rft.aulast=Verbeek&rft.aufirst=Jos&rft.date=2014-03-01&rft.volume=53&rft.issue=S2&rft.spage=S84&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2013.857436 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Copyright - Copyright Decker Publishing Inc. Mar 2014 N1 - Date revised - 2015-09-22 N1 - Last updated - 2016-10-06 DO - http://dx.doi.org/10.3109/14992027.2013.857436 ER - TY - JOUR T1 - Short-term variability of pure-tone thresholds obtained with TDH-39P earphones AN - 1665157084 AB - Objective: To estimate the short-term variability and correlates of variability in pure-tone thresholds obtained using audiometric equipment designed for occupational use, and to examine the justification for excluding 8 kHz as a mandatory threshold in occupational hearing conservation programs. Method: Pure-tone thresholds and other hearing-related tests (e.g. noise dosimetry, otoscopy, middle-ear assessment) were conducted with a group of 527 adults between 20 and 69 years of age. Five measurement visits were completed by participants within 14 days. Results: The 50% critical difference boundaries were - 5 and 0 dB at 4 kHz and below and - 5 and 5 dB at 6 and 8 kHz. The likelihood of spurious notches due to test-retest variability was substantially lower than the likelihood of failing to detect a notched configuration when present. Correlates of variability included stimulus frequency, baseline threshold, acoustic reflectance of the ear, average noise exposure during the previous eight hours, age, and the testerʼs level of education in audiology. Conclusion: The short-term variability in 8-kHz pure-tone thresholds obtained with the TDH-39P earphone was slightly greater than at other frequencies, but this difference was not large enough to justify the disadvantages stemming from the inability to detect a 6-kHz notch. JF - International Journal of Audiology AU - Stephenson, Mark R AU - Deiters, Kristy K AU - Hessenauer, Amanda AU - VanGessel, Devon K AU - Geda, Kyle AU - Wyllys, Krista AU - McGregor, Kara D AD - Division of Applied Research and Technology, National Institute for Occupational Safety and Health, Cincinnati, Ohio, USA ; Department of Speech Pathology and Audiology, Western Michigan University, Kalamazoo, USA ; Flamme, Gregory A; Department of Speech Pathology and Audiology, Western Michigan University, 1903 W. Michigan Ave., Kalamazoo, MI 49008, USA Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - S5 EP - S15 CY - Hamilton PB - Taylor & Francis Ltd. VL - 53 IS - S2 SN - 1499-2027 KW - Medical Sciences--Otorhinolaryngology KW - Audiometry KW - noise-induced hearing loss KW - reliability KW - occupational health KW - Audiology KW - Thresholds KW - Variability KW - Equipment KW - Hearing KW - Justification KW - Measurement KW - Noise KW - Noise exposure KW - Short term KW - Stimulus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1665157084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Audiology&rft.atitle=Short-term+variability+of+pure-tone+thresholds+obtained+with+TDH-39P+earphones&rft.au=Flamme%2C+Gregory+A%3BStephenson%2C+Mark+R%3BDeiters%2C+Kristy+K%3BHessenauer%2C+Amanda%3BVanGessel%2C+Devon+K%3BGeda%2C+Kyle%3BWyllys%2C+Krista%3BMcGregor%2C+Kara+D&rft.aulast=Flamme&rft.aufirst=Gregory&rft.date=2014-03-01&rft.volume=53&rft.issue=S2&rft.spage=S5&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Audiology&rft.issn=14992027&rft_id=info:doi/10.3109%2F14992027.2013.857435 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-09-22 N1 - Last updated - 2016-08-16 DO - http://dx.doi.org/10.3109/14992027.2013.857435 ER - TY - JOUR T1 - Factors Associated With Heat Strain Among Workers at an Aluminum Smelter in Texas AN - 1560115166; 20589544 AB - Objectives: To determine the prevalence of heat strain and factors associated with heat strain among workers at an aluminum smelter in Texas. Methods: Continuous core body temperature (T sub(c)), heart rate, and pre- and postshift serum electrolytes, and unne specific gravity were measured, and symptom questionnaires were administered. Results: Most participants (54%) had 1 or more signs of heat strain Unacclimatized participants were significantly more likely to exceed the American Conference of Governmental Industrial Hygiemsts-recommended T sub(c) than acclimatized participants (88% vs 20%, P < 0 01) Participants who exceeded the T sub(c) for their acclimatization status and/or exceeded the recommended sustained peak HR had a significantly lower body mass index than those who did not (27 6 vs 31 8 and 28 4 vs 32 4, respectively, P = 0 01). Conclusions: Employees and management need to strictly adhere to a heat stress management program to minimize heat stress and strain JF - Journal of Occupational and Environmental Medicine AU - Dang, Bich N AU - Dowell, Chad H AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, 1600 Clifton Road NE, Atlanta, Georgia 30333; Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, Ohio; Baylor College of Medicine, Department of Medicine, Houston, Texas; Michael E. DeBakey Veterans Affairs Medical Center, Center for Innovations in Quality, Effectiveness and Safety, Houston Texas, cdowell@cdc.gov PY - 2014 SP - 313 EP - 318 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 56 IS - 3 SN - 1076-2752, 1076-2752 KW - Health & Safety Science Abstracts KW - Electrolytes KW - Conferences KW - Body mass KW - Aluminum KW - Heart rate KW - Heat tolerance KW - Temperature KW - USA, Texas KW - Mining KW - Smelters KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560115166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Occupational+and+Environmental+Medicine&rft.atitle=Factors+Associated+With+Heat+Strain+Among+Workers+at+an+Aluminum+Smelter+in+Texas&rft.au=Dang%2C+Bich+N%3BDowell%2C+Chad+H&rft.aulast=Dang&rft.aufirst=Bich&rft.date=2014-03-01&rft.volume=56&rft.issue=3&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Journal+of+Occupational+and+Environmental+Medicine&rft.issn=10762752&rft_id=info:doi/10.1097%2FJOM.0000000000000095 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2015-12-23 N1 - SubjectsTermNotLitGenreText - Electrolytes; Conferences; Body mass; Heart rate; Aluminum; Temperature; Heat tolerance; Mining; Smelters; USA, Texas DO - http://dx.doi.org/10.1097/JOM.0000000000000095 ER - TY - JOUR T1 - Assessment of tissue allograft safety monitoring with administrative healthcare databases: a pilot project using Medicare data AN - 1534828734; 19362485 AB - Assess whether Medicare data are useful for monitoring tissue allograft safety and utilization. We used health care claims (billing) data from 2007 for 35 million fee-for-service Medicare beneficiaries, a predominantly elderly population. Using search terms for transplant-related procedures, we generated lists of ICD-9-CM and CPT super( registered ) codes and assessed the frequency of selected allograft procedures. Step 1 used inpatient data and ICD-9-CM procedure codes. Step 2 added non-institutional provider (e.g., physician) claims, outpatient institutional claims, and CPT codes. We assembled preliminary lists of diagnosis codes for infections after selected allograft procedures. Many ICD-9-CM codes were ambiguous as to whether the procedure involved an allograft. Among 1.3 million persons with a procedure ascertained using the list of ICD-9-CM codes, only 1,886 claims clearly involved an allograft. CPT codes enabled better ascertainment of some allograft procedures (over 17,000 persons had corneal transplants and over 2,700 had allograft skin transplants). For spinal fusion procedures, CPT codes improved specificity for allografts; of nearly 100,000 patients with ICD-9-CM codes for spinal fusions, more than 34,000 had CPT codes indicating allograft use. Monitoring infrequent events (infections) after infrequent exposures (tissue allografts) requires large study populations. A strength of the large Medicare databases is the substantial number of certain allograft procedures. Limitations include lack of clinical detail and donor information. Medicare data can potentially augment passive reporting systems and may be useful for monitoring tissue allograft safety and utilization where codes clearly identify allograft use and coding algorithms can effectively screen for infections. JF - Cell and Tissue Banking AU - Dhakal, Sanjaya AU - Burwen, Dale R AU - Polakowski, Laura L AU - Zinderman, Craig E AU - Wise, Robert P AD - Division of Epidemiology (DE), Office of Biostatistics and Epidemiology (OBE), Center for Biologics Evaluation and Research (CBER), Food and Drug Administration, 1401 Rockville Pike WOC I 441 S, Rockville, MD, 20852, USA, craig.zinderman@fda.hhs.gov Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 75 EP - 84 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 15 IS - 1 SN - 1389-9333, 1389-9333 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Donors KW - Data processing KW - Skin KW - Cornea KW - Algorithms KW - Geriatrics KW - Population studies KW - Infection KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534828734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+and+Tissue+Banking&rft.atitle=Assessment+of+tissue+allograft+safety+monitoring+with+administrative+healthcare+databases%3A+a+pilot+project+using+Medicare+data&rft.au=Dhakal%2C+Sanjaya%3BBurwen%2C+Dale+R%3BPolakowski%2C+Laura+L%3BZinderman%2C+Craig+E%3BWise%2C+Robert+P&rft.aulast=Dhakal&rft.aufirst=Sanjaya&rft.date=2014-03-01&rft.volume=15&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Cell+and+Tissue+Banking&rft.issn=13899333&rft_id=info:doi/10.1007%2Fs10561-013-9376-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Number of references - 28 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Databases; Donors; Skin; Data processing; Cornea; Geriatrics; Algorithms; Population studies; Infection DO - http://dx.doi.org/10.1007/s10561-013-9376-y ER - TY - JOUR T1 - Evaluation of butyrate-induced production of a mannose-6-phosphorylated therapeutic enzyme using parallel bioreactors AN - 1524425518; 19744798 AB - Bioreactor process changes can have a profound effect on the yield and quality of biotechnology products. Mannose-6-phosphate (M6P) glycan content and the enzymatic catalytic kinetic parameters are critical quality attributes (CQAs) of many therapeutic enzymes used to treat lysosomal storage diseases (LSDs). Here, we have evaluated the effect of adding butyrate to bioreactor production cultures of human recombinant [Formulaomitted]-glucuronidase produced from CHO-K1 cells, with an emphasis on CQAs. The [Formulaomitted]-glucuronidase produced in parallel bioreactors was quantified by capillary electrophoresis, the catalytic kinetic parameters were measured using steady-state analysis, and mannose-6-phosphorylation status was assessed using an M6P-specific single-chain antibody fragment. Using this approach, we found that butyrate treatment increased [Formulaomitted]-glucuronidase production up to approximately threefold without significantly affecting the catalytic properties of the enzyme. However, M6P content in [Formulaomitted]-glucuronidase was inversely correlated with the increased enzyme production induced by butyrate treatment. This assessment demonstrated that although butyrate dramatically increased [Formulaomitted]-glucuronidase production in bioreactors, it adversely impacted the mannose-6-phosphorylation of this LSD therapeutic enzyme. This strategy may have utility in evaluating manufacturing process changes to improve therapeutic enzyme yields and CQAs. JF - Biotechnology and Applied Biochemistry AU - Madhavarao, Chikkathur N AU - Agarabi, Cyrus D AU - Wong, Lily AU - Mueller-Loennies, Sven AU - Braulke, Thomas AU - Khan, Mansoor AU - Anderson, Howard AU - Johnson, Gibbes R AD - Division of Therapeutic Proteins, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 184 EP - 192 PB - John Wiley & Sons, Ltd., Baffins Lane Chichester W. Sussex PO19 1UD United Kingdom VL - 61 IS - 2 SN - 0885-4513, 0885-4513 KW - Biotechnology and Bioengineering Abstracts KW - lysosomal storage diseases KW - enzyme replacement therapies KW - mannose-6-phosphate KW - enzymes KW - bioreactors KW - capillary electrophoresis KW - Antibodies KW - Bioreactors KW - Kinetics KW - Enzymes KW - lysergide KW - Cell culture KW - Polysaccharides KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524425518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biotechnology+and+Applied+Biochemistry&rft.atitle=Evaluation+of+butyrate-induced+production+of+a+mannose-6-phosphorylated+therapeutic+enzyme+using+parallel+bioreactors&rft.au=Madhavarao%2C+Chikkathur+N%3BAgarabi%2C+Cyrus+D%3BWong%2C+Lily%3BMueller-Loennies%2C+Sven%3BBraulke%2C+Thomas%3BKhan%2C+Mansoor%3BAnderson%2C+Howard%3BJohnson%2C+Gibbes+R&rft.aulast=Madhavarao&rft.aufirst=Chikkathur&rft.date=2014-03-01&rft.volume=61&rft.issue=2&rft.spage=184&rft.isbn=&rft.btitle=&rft.title=Biotechnology+and+Applied+Biochemistry&rft.issn=08854513&rft_id=info:doi/10.1002%2Fbab.1151 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - lysosomal storage diseases; Antibodies; Kinetics; Bioreactors; capillary electrophoresis; lysergide; Enzymes; Cell culture; Polysaccharides DO - http://dx.doi.org/10.1002/bab.1151 ER - TY - JOUR T1 - Surveillance for Yellow Fever Virus in Non-Human Primates in Southern Brazil, 2001-2011: A Tool for Prioritizing Human Populations for Vaccination AN - 1516726971; 24625681 AB - In Brazil, epizootics among New World monkey species may indicate circulation of yellow fever (YF) virus and provide early warning of risk to humans. Between 1999 and 2001, the southern Brazilian state of Rio Grande do Sul initiated surveillance for epizootics of YF in non-human primates to inform vaccination of human populations. Following a YF outbreak, we analyzed epizootic surveillance data and assessed YF vaccine coverage, timeliness of implementation of vaccination in unvaccinated human populations. From October 2008 through June 2009, circulation of YF virus was confirmed in 67 municipalities in Rio Grande do Sul State; vaccination was recommended in 23 (34%) prior to the outbreak and in 16 (24%) within two weeks of first epizootic report. In 28 (42%) municipalities, vaccination began more than two weeks after first epizootic report. Eleven (52%) of 21 laboratory-confirmed human YF cases occurred in two municipalities with delayed vaccination. By 2010, municipalities with confirmed YF epizootics reported higher vaccine coverage than other municipalities that began vaccination. In unvaccinated human populations timely response to epizootic events is critical to prevent human yellow fever cases. JF - PLoS Neglected Tropical Diseases AU - Almeida, Marco AB AU - Cardoso, Jader daC AU - Santos, Edmilson dos AU - Fonseca, Daltro Fda AU - Cruz, Laura L AU - Faraco, Fernando JC AU - Bercini, Marilina A AU - Vettorello, Kátia C AU - Porto, Mariana A AU - Mohrdieck, Renate AU - Ranieri, Tani MS AU - Schermann, Maria T AU - Sperb, Alethéa F AU - Paz, Francisco Z AU - Nunes, Zenaida MA AU - Romano, Alessandro PM AU - Costa, Zouraide G AU - Gomes, Silvana L AU - Flannery, Brendan Y1 - 2014/03// PY - 2014 DA - Mar 2014 EP - e2741 CY - San Francisco PB - Public Library of Science VL - 8 IS - 3 KW - Medical Sciences--Communicable Diseases KW - Yellow Fever Vaccine KW - Primates KW - Immunization KW - Vaccines KW - Infections KW - Monkeys & apes KW - Rio Grande KW - South America KW - Brazil KW - Animals KW - Yellow Fever -- virology KW - Yellow Fever -- prevention & control KW - Vaccination -- methods KW - Primate Diseases -- virology KW - Humans KW - Brazil -- epidemiology KW - Epidemiological Monitoring KW - Haplorhini KW - Yellow Fever -- epidemiology KW - Yellow fever virus -- isolation & purification KW - Yellow Fever -- veterinary KW - Primate Diseases -- epidemiology KW - Yellow Fever Vaccine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516726971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Surveillance+for+Yellow+Fever+Virus+in+Non-Human+Primates+in+Southern+Brazil%2C+2001-2011%3A+A+Tool+for+Prioritizing+Human+Populations+for+Vaccination%3A+e2741&rft.au=Almeida%2C+Marco+AB%3BCardoso%2C+Jader+daC%3BSantos%2C+Edmilson+dos%3BFonseca%2C+Daltro+Fda%3BCruz%2C+Laura+L%3BFaraco%2C+Fernando+JC%3BBercini%2C+Marilina+A%3BVettorello%2C+K%C3%A1tia+C%3BPorto%2C+Mariana+A%3BMohrdieck%2C+Renate%3BRanieri%2C+Tani+MS%3BSchermann%2C+Maria+T%3BSperb%2C+Aleth%C3%A9a+F%3BPaz%2C+Francisco+Z%3BNunes%2C+Zenaida+MA%3BRomano%2C+Alessandro+PM%3BCosta%2C+Zouraide+G%3BGomes%2C+Silvana+L%3BFlannery%2C+Brendan&rft.aulast=Almeida&rft.aufirst=Marco&rft.date=2014-03-01&rft.volume=8&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=&rft_id=info:doi/10.1371%2Fjournal.pntd.0002741 LA - English DB - ProQuest Central N1 - Copyright - © 2014 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Citation: Almeida MAB, Cardoso JdC, dos Santos E, da Fonseca DF, Cruz LL, et al. (2014) Surveillance for Yellow Fever Virus in Non-Human Primates in Southern Brazil, 2001-2011: A Tool for Prioritizing Human Populations for Vaccination. PLoS Negl Trop Dis 8(3): e2741. doi:10.1371/journal.pntd.0002741 N1 - Last updated - 2014-10-17 N1 - SubjectsTermNotLitGenreText - Brazil; Rio Grande; South America DO - http://dx.doi.org/10.1371/journal.pntd.0002741 ER - TY - JOUR T1 - K114 inhibits A-beta aggregation and inflammation in vitro and in vivo in AD/Tg mice. AN - 1513046529; 24552157 AB - Alzheimer's disease (AD) is the most common age related human neurodegenerative disorder. The major histopathological characteristics of the AD brain are extracellular amyloid-beta (Aβ) peptide loaded plaques and intraneuronal neurofibrillary tangles made of phosphorylated tau proteins. Amyloid plaques consist primarily of aggregated Aβ1-42 and Aβ1-40 peptides. The aim of our current study was to test novel ligands/agents with the potential to disrupt or inhibit the aggregation of Aβ peptide, specifically K114, (trans,trans)-1-bromo-2,5-bis(4-hydroxystyryl)benzene, which was initially developed as a potential positron emission tomography (PET) ligand for the in vivo detection of amyloid plaques. Systemic administration of K114 has been shown in the AD/transgenic (Tg) mouse model to be capable of crossing the blood-brain barrier (BBB) and be colocalized with amyloid plaques. In this study we determined whether K114 has the potential to inhibit Aβ aggregation in vitro in AD/Tg mice and also tested, in vivo, whether chronic daily orally administered K114 has any therapeutic potential as evidenced by inhibition or reduction of the deposits of amyloid aggregates in the brains of AD/Tg mice. Our results demonstrated that K114 strongly blocked, in vitro, the aggregation of Aβ peptide in the amyloid plaques of AD/Tg mouse brain. Systemic treatment with K114 was also effective in significantly reducing the deposits of amyloid plaques in the brains of living transgenic AD mice. Additionally, K114 significantly inhibited the typically observed plaque associated astrocytic activation, as revealed by GFAP immunohistochemistry, suggesting possible anti-inflammatory properties. JF - Current Alzheimer research AU - Zhang, Yi-Hong AU - Mann, Dushyant AU - Raymick, James AU - Sarkar, Sumit AU - Paule, Merle G AU - Lahiri, Debomoy K AU - Dumas, Melanie AU - Bell-Cohen, Ashlee AU - Schmued, Larry C AD - Division of Neurotoxicology, National Center for Toxicological Research (NCTR)/FDA, Jefferson, AR 72079, USA. larry.schmued@fda.hhs.gov. Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 299 EP - 308 VL - 11 IS - 3 KW - 1-bromo-2,5-bis(4-hydroxystyryl)benzene KW - 0 KW - Aif1 protein, mouse KW - Amyloid beta-Peptides KW - Amyloid beta-Protein Precursor KW - Antigens, CD KW - Antigens, Differentiation, Myelomonocytic KW - CD68 antigen, human KW - Calcium-Binding Proteins KW - Glial Fibrillary Acidic Protein KW - Microfilament Proteins KW - PSEN1 protein, human KW - Peptide Fragments KW - Presenilin-1 KW - Styrenes KW - amyloid beta-protein (1-40) KW - amyloid beta-protein (1-42) KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Microfilament Proteins -- metabolism KW - Humans KW - Glial Fibrillary Acidic Protein -- metabolism KW - Disease Models, Animal KW - Mice KW - Mice, Transgenic KW - Amyloid beta-Protein Precursor -- genetics KW - Plaque, Amyloid -- etiology KW - Plaque, Amyloid -- drug therapy KW - In Vitro Techniques KW - Antigens, CD -- metabolism KW - Mice, Inbred C57BL KW - Mutation -- genetics KW - Antigens, Differentiation, Myelomonocytic -- metabolism KW - Calcium-Binding Proteins -- metabolism KW - Presenilin-1 -- genetics KW - Styrenes -- pharmacology KW - Peptide Fragments -- metabolism KW - Alzheimer Disease -- genetics KW - Amyloid beta-Peptides -- metabolism KW - Alzheimer Disease -- complications KW - Encephalitis -- etiology KW - Encephalitis -- drug therapy KW - Styrenes -- therapeutic use KW - Alzheimer Disease -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1513046529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Alzheimer+research&rft.atitle=K114+inhibits+A-beta+aggregation+and+inflammation+in+vitro+and+in+vivo+in+AD%2FTg+mice.&rft.au=Zhang%2C+Yi-Hong%3BMann%2C+Dushyant%3BRaymick%2C+James%3BSarkar%2C+Sumit%3BPaule%2C+Merle+G%3BLahiri%2C+Debomoy+K%3BDumas%2C+Melanie%3BBell-Cohen%2C+Ashlee%3BSchmued%2C+Larry+C&rft.aulast=Zhang&rft.aufirst=Yi-Hong&rft.date=2014-03-01&rft.volume=11&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Current+Alzheimer+research&rft.issn=1875-5828&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-17 N1 - Date created - 2014-04-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Impact of long-term exposure to sodium arsenite on cytogenetic radiation damage AN - 1512323270; 19339694 AB - The aim of this work was to investigate the impact of long-term exposure to low concentrations of sodium arsenite on the cellular response to ionising radiation. Human lymphoblastoid GM1899a cells were cultured in the presence of sodium arsenite for up to six months. Following chemical exposure, acute challenge doses of X-rays were given and chromosome damage (dicentrics, acentric fragments, translocations, micronuclei) as well as cell growth and changes in cell cycle kinetics were determined. Initial short-term chemical exposures determined 8ng/ml (60nM) sodium arsenite as a suitable concentration for chronic exposures, which is below the current World Health Organization limit for arsenic in drinking water. At this concentration, cell growth was slightly, but consistently, slower than in untreated cultures throughout the six-month exposure period. Long-term exposure to the chemical induced no dicentrics and did not significantly alter the yield of dicentrics induced by 1 Gy acute X-irradiation. Similar results were obtained for chromosome translocations. In contrast, exposure to 8ng/ml sodium arsenite induced significant levels of acentric fragments and micronuclei. Fragment/micronuclei data in combined treatment samples compared with single treatments were consistent with an additive effect of chemical and radiation exposure. As for X-rays, micronuclei induced by sodium arsenite tended to show no centromere in situ hybridisation signal, indicating that they represent structural aberrations rather than mis-segregated chromosomes. Similar results were obtained in human peripheral lymphocytes following short-term exposure to sodium arsenite or X-rays. Overall, an additive effect was observed for all combined exposures. Cellular radiation responses therefore seem to operate without any modulatory effects from chronic low level exposure to sodium arsenite in the systems analysed here. JF - Mutagenesis AU - Nuta, Otilia AU - Moquet, Jayne AU - Bouffler, Simon AU - Lloyd, David AU - Sepai, Ovnair AU - Rothkamm, Kai AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon, OX11 0RQ, UK, kai.rothkamm@phe.gov.uk Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 123 EP - 129 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 29 IS - 2 SN - 0267-8357, 0267-8357 KW - Toxicology Abstracts; Genetics Abstracts KW - X radiation KW - Arsenic KW - Data processing KW - Sodium arsenite KW - Cell cycle KW - Micronuclei KW - Cell culture KW - Lymphocytes KW - Centromeres KW - Mutagenesis KW - Chromosome translocations KW - Radiation KW - Chronic exposure KW - Kinetics KW - Ionizing radiation KW - Drinking water KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1512323270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Impact+of+long-term+exposure+to+sodium+arsenite+on+cytogenetic+radiation+damage&rft.au=Nuta%2C+Otilia%3BMoquet%2C+Jayne%3BBouffler%2C+Simon%3BLloyd%2C+David%3BSepai%2C+Ovnair%3BRothkamm%2C+Kai&rft.aulast=Nuta&rft.aufirst=Otilia&rft.date=2014-03-01&rft.volume=29&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=02678357&rft_id=info:doi/10.1093%2Fmutage%2Fget070 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2015-06-12 N1 - SubjectsTermNotLitGenreText - Arsenic; X radiation; Sodium arsenite; Data processing; Micronuclei; Cell cycle; Cell culture; Lymphocytes; Mutagenesis; Centromeres; Radiation; Chromosome translocations; Chronic exposure; Ionizing radiation; Kinetics; Drinking water DO - http://dx.doi.org/10.1093/mutage/get070 ER - TY - JOUR T1 - Time to Detection of Mycobacterium tuberculosis Using the MGIT 320 System Correlates with Colony Counting in Preclinical Testing of New Vaccines AN - 1508762055; 19402753 AB - Clinical studies have suggested that the enumeration of mycobacteria by using automated liquid systems is a faster and simpler alternative to quantitative cultures. Here, we show that the time to detection of M. tuberculosis growth as measured with the MGIT 320 liquid culture system inversely correlates with CFU determinations from culture on solid media and that mycobacterial quantification using the MGIT system is faster and easier to perform than CFU plating. JF - Clinical and Vaccine Immunology AU - Kolibab, K AU - Yang, A AU - Parra, M AU - Derrick, S C AU - Morris, S L Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 453 EP - 455 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 21 IS - 3 SN - 1556-679X, 1556-679X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Colonies KW - Colony-forming cells KW - Liquid culture KW - Tuberculosis KW - Enumeration KW - Vaccines KW - Media (culture) KW - Mycobacterium tuberculosis KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1508762055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Time+to+Detection+of+Mycobacterium+tuberculosis+Using+the+MGIT+320+System+Correlates+with+Colony+Counting+in+Preclinical+Testing+of+New+Vaccines&rft.au=Kolibab%2C+K%3BYang%2C+A%3BParra%2C+M%3BDerrick%2C+S+C%3BMorris%2C+S+L&rft.aulast=Kolibab&rft.aufirst=K&rft.date=2014-03-01&rft.volume=21&rft.issue=3&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=1556679X&rft_id=info:doi/10.1128%2FCVI.00742-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-01 N1 - Number of references - 20 N1 - Last updated - 2014-06-26 N1 - SubjectsTermNotLitGenreText - Colonies; Liquid culture; Colony-forming cells; Tuberculosis; Vaccines; Enumeration; Media (culture); Mycobacterium tuberculosis DO - http://dx.doi.org/10.1128/CVI.00742-13 ER - TY - JOUR T1 - Genetic Evidence for the Involvement of the S-Layer Protein Gene sap and the Sporulation Genes spo0A, spo0B, and spo0F in Phage AP50c Infection of Bacillus anthracis AN - 1508758450; 19402796 AB - In order to better characterize the Bacillus anthracis typing phage AP50c, we designed a genetic screen to identify its bacterial receptor. Insertions of the transposon mariner or targeted deletions of the structural gene for the S-layer protein Sap and the sporulation genes spo0A, spo0B, and spo0F in B. anthracis Sterne resulted in phage resistance with concomitant defects in phage adsorption and infectivity. Electron microscopy of bacteria incubated with AP50c revealed phage particles associated with the surface of bacilli of the Sterne strain but not with the surfaces of Delta sap, Delta spo0A, Delta spo0B, or Delta spo0F mutants. The amount of Sap in the S layer of each of the spo0 mutant strains was substantially reduced compared to that of the parent strain, and incubation of AP50c with purified recombinant Sap led to a substantial reduction in phage activity. Phylogenetic analysis based on whole-genome sequences of B. cereus sensu lato strains revealed several closely related B. cereus and B. thuringiensis strains that carry sap genes with very high similarities to the sap gene of B. anthracis. Complementation of the Delta sap mutant in trans with the wild-type B. anthracis sap or the sap gene from either of two different B. cereus strains that are sensitive to AP50c infection restored phage sensitivity, and electron microscopy confirmed attachment of phage particles to the surface of each of the complemented strains. Based on these data, we postulate that Sap is involved in AP50c infectivity, most likely acting as the phage receptor, and that the spo0 genes may regulate synthesis of Sap and/or formation of the S layer. JF - Journal of Bacteriology AU - Plaut, Roger D AU - Beaber, John W AU - Zemansky, Jason AU - Kaur, Ajinder P AU - George, Matroner AU - Biswas, Biswajit AU - Henry, Matthew AU - Bishop-Lilly, Kimberly A AU - Mokashi, Vishwesh AU - Hannah, Ryan M AD - Division of Bacterial, Parasitic, and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, USA, Roger.Plaut@fda.hhs.gov. Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 1143 EP - 1154 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 United States VL - 196 IS - 6 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Phages KW - Bacilli KW - Data processing KW - SAP gene KW - transposon Mariner KW - Sporulation KW - SAP protein KW - Bacillus anthracis KW - Infection KW - Infectivity KW - Gene deletion KW - Complementation KW - Typing KW - Insertion KW - Adsorption KW - Genetic screening KW - Electron microscopy KW - J 02310:Genetics & Taxonomy KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1508758450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Genetic+Evidence+for+the+Involvement+of+the+S-Layer+Protein+Gene+sap+and+the+Sporulation+Genes+spo0A%2C+spo0B%2C+and+spo0F+in+Phage+AP50c+Infection+of+Bacillus+anthracis&rft.au=Plaut%2C+Roger+D%3BBeaber%2C+John+W%3BZemansky%2C+Jason%3BKaur%2C+Ajinder+P%3BGeorge%2C+Matroner%3BBiswas%2C+Biswajit%3BHenry%2C+Matthew%3BBishop-Lilly%2C+Kimberly+A%3BMokashi%2C+Vishwesh%3BHannah%2C+Ryan+M&rft.aulast=Plaut&rft.aufirst=Roger&rft.date=2014-03-01&rft.volume=196&rft.issue=6&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/10.1128%2FJB.00739-13 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-01 N1 - Number of references - 71 N1 - Last updated - 2016-08-03 N1 - SubjectsTermNotLitGenreText - Phages; Phylogeny; Bacilli; Data processing; SAP gene; transposon Mariner; Sporulation; SAP protein; Infection; Gene deletion; Infectivity; Typing; Complementation; Insertion; Adsorption; Genetic screening; Electron microscopy; Bacillus anthracis DO - http://dx.doi.org/10.1128/JB.00739-13 ER - TY - JOUR T1 - Stereolithography in tissue engineering AN - 1508757819; 19380776 AB - Several recent research efforts have focused on use of computer-aided additive fabrication technologies, commonly referred to as additive manufacturing, rapid prototyping, solid freeform fabrication, or three-dimensional printing technologies, to create structures for tissue engineering. For example, scaffolds for tissue engineering may be processed using rapid prototyping technologies, which serve as matrices for cell ingrowth, vascularization, as well as transport of nutrients and waste. Stereolithography is a photopolymerization-based rapid prototyping technology that involves computer-driven and spatially controlled irradiation of liquid resin. This technology enables structures with precise microscale features to be prepared directly from a computer model. In this review, use of stereolithography for processing trimethylene carbonate, polycaprolactone, and poly(d,l-lactide) poly(propylene fumarate)-based materials is considered. In addition, incorporation of bioceramic fillers for fabrication of bioceramic scaffolds is reviewed. Use of stereolithography for processing of patient-specific implantable scaffolds is also discussed. In addition, use of photopolymerization-based rapid prototyping technology, known as two-photon polymerization, for production of tissue engineering scaffolds with smaller features than conventional stereolithography technology is considered. JF - Journal of Materials Science: Materials in Medicine AU - Skoog, Shelby A AU - Goering, Peter L AU - Narayan, Roger J AD - Division of Biology, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA, roger_narayan@msn.com Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 845 EP - 856 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 25 IS - 3 SN - 0957-4530, 0957-4530 KW - Biotechnology and Bioengineering Abstracts KW - Resins KW - Printing KW - Polymerization KW - Mathematical models KW - polycaprolactone KW - vascularization KW - Wastes KW - Nutrients KW - Tissue engineering KW - scaffolds KW - Radiation KW - Reviews KW - carbonates KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1508757819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Materials+Science%3A+Materials+in+Medicine&rft.atitle=Stereolithography+in+tissue+engineering&rft.au=Skoog%2C+Shelby+A%3BGoering%2C+Peter+L%3BNarayan%2C+Roger+J&rft.aulast=Skoog&rft.aufirst=Shelby&rft.date=2014-03-01&rft.volume=25&rft.issue=3&rft.spage=845&rft.isbn=&rft.btitle=&rft.title=Journal+of+Materials+Science%3A+Materials+in+Medicine&rft.issn=09574530&rft_id=info:doi/10.1007%2Fs10856-013-5107-y LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-01 N1 - Number of references - 59 N1 - Last updated - 2015-03-20 N1 - SubjectsTermNotLitGenreText - Resins; polycaprolactone; Mathematical models; Polymerization; Printing; vascularization; Wastes; Nutrients; Tissue engineering; scaffolds; Radiation; Reviews; carbonates DO - http://dx.doi.org/10.1007/s10856-013-5107-y ER - TY - JOUR T1 - Shift work and cancer screening: Do females who work alternative shifts undergo recommended cancer screening? AN - 1505340323; 19337988 AB - Background Alternative shift work is classified as a probable human carcinogen. Certain cancer screening tests reduce cancer mortality. Methods The 2010 National Health Interview Survey was used to examine associations between adherence to breast, cervical, and colon cancer screening recommendations and alternative shift work among female workers. Results Workers on alternative shifts, compared to workers on daytime shifts, were more likely to be non-adherent to screening recommendations for breast (34% vs. 23%) and colorectal (55% vs. 48%) cancer (P<0.05). Workers on alternative shifts in two industries ("Manufacturing" and "Accommodation/Food Services") and three occupations ("Food Preparation/Serving," "Personal Care Services," and "Production") were more likely to be non-adherent to screening recommendations for at least two cancers (P<0.05). Conclusions The Affordable Care Act eliminates out-of-pocket screening expenses for these three cancers. Greater efforts are needed to promote this benefit, particularly among workers with demonstrated non-adherence. Am. J. Ind. Med. 57:265-275, 2014. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Tsai, Rebecca J AU - Luckhaupt, Sara E AU - Sweeney, Marie Haring AU - Calvert, Geoffrey M AD - Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio. Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 265 EP - 275 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 3 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - Shift work KW - Mortality KW - USA KW - Carcinogens KW - Females KW - Working conditions KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1505340323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Shift+work+and+cancer+screening%3A+Do+females+who+work+alternative+shifts+undergo+recommended+cancer+screening%3F&rft.au=Tsai%2C+Rebecca+J%3BLuckhaupt%2C+Sara+E%3BSweeney%2C+Marie+Haring%3BCalvert%2C+Geoffrey+M&rft.aulast=Tsai&rft.aufirst=Rebecca&rft.date=2014-03-01&rft.volume=57&rft.issue=3&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22285 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-01 N1 - Last updated - 2014-06-12 N1 - SubjectsTermNotLitGenreText - Mortality; Shift work; Females; Carcinogens; Working conditions; USA DO - http://dx.doi.org/10.1002/ajim.22285 ER - TY - JOUR T1 - Ethinyl estradiol and other human pharmaceutical estrogens in the aquatic environment: a review of recent risk assessment data. AN - 1502329936; 24470211 AB - Interest in pharmaceuticals in the environment has increased substantially in recent years. Several studies in particular have assessed human and ecological risks from human pharmaceutical estrogens, such as 17α-ethinyl estradiol (EE2). Regulatory action also has increased, with the USA and other countries developing rules to address estrogens and other pharmaceuticals in the environment. Accordingly, the Center for Drug Evaluation and Research at the US Food and Drug Administration has conducted a review and analysis of current data on the long-term ecological exposure and effects of EE2 and other estrogens. The results indicate that mean-flow long-term predicted environmental concentrations (PECs) of EE2 in approximately 99% or more of US surface water segments downstream of wastewater treatment plants are lower than a predicted no-effect concentration (PNEC) for aquatic chronic toxicity of 0.1 ng/L. Exceedances are expected to be primarily in localized, effluent-dominated water segments. The median mean-flow PEC is more than two orders of magnitude lower than this PNEC. Similar results exist for other pharmaceutical estrogens. Data also suggest that the contribution of EE2 more broadly to total estrogenic load in the environment from all sources (including other human pharmaceutical estrogens, endogenous estrogens, natural environmental estrogens, and industrial chemicals), while highly uncertain and variable, appears to be relatively low overall. Additional data and a more comprehensive approach for data collection and analysis for estrogenic substances in the environment, especially in effluent-dominated water segments in sensitive environments, would more fully characterize the risks. JF - The AAPS journal AU - Laurenson, James P AU - Bloom, Raanan A AU - Page, Stephen AU - Sadrieh, Nakissa AD - Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, Maryland, 20903, USA, james.laurenson@fda.hhs.gov. Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 299 EP - 310 VL - 16 IS - 2 KW - Estrogens KW - 0 KW - Pharmaceutical Preparations KW - Water Pollutants, Chemical KW - Ethinyl Estradiol KW - 423D2T571U KW - Index Medicus KW - Ecology KW - Humans KW - Risk Assessment KW - Water Pollutants, Chemical -- analysis KW - Ethinyl Estradiol -- analysis KW - Estrogens -- analysis KW - Pharmaceutical Preparations -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1502329936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Ethinyl+estradiol+and+other+human+pharmaceutical+estrogens+in+the+aquatic+environment%3A+a+review+of+recent+risk+assessment+data.&rft.au=Laurenson%2C+James+P%3BBloom%2C+Raanan+A%3BPage%2C+Stephen%3BSadrieh%2C+Nakissa&rft.aulast=Laurenson&rft.aufirst=James&rft.date=2014-03-01&rft.volume=16&rft.issue=2&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/10.1208%2Fs12248-014-9561-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-22 N1 - Date created - 2014-02-25 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: AAPS J. 2012 Dec;14(4):688-702 [22767270] Toxicol Lett. 2013 Dec 16;223(3):280-6 [23542818] Sensors (Basel). 2012;12(9):12741-71 [23112741] Sci Total Environ. 2013 Jan 15;443:324-37 [23201698] Contraception. 2013 Mar;87(3):347-51 [22974594] J Chromatogr A. 2013 Mar 29;1283:39-45 [23465128] Contraception. 2013 Jun;87(6):706-27 [23375353] Reprod Toxicol. 2013 Jul;38:1-15 [23411111] Environ Toxicol Chem. 2001 Jan;20(1):133-9 [11351400] Toxicology. 2001 Sep 14;166(1-2):79-89 [11518614] Environ Health Perspect. 2002 Feb;110 Suppl 1:25-42 [11834461] Environ Sci Technol. 2002 Apr 15;36(8):1751-6 [11993873] Environ Health Perspect. 2002 Sep;110(9):917-21 [12204827] Aquat Toxicol. 2003 Jan 24;62(2):85-103 [12505378] Anal Bioanal Chem. 2004 Feb;378(3):697-708 [14658021] Environ Sci Technol. 2004 Feb 1;38(3):838-49 [14968872] J Pharmacol Exp Ther. 1999 Aug;290(2):740-7 [10411586] Environ Sci Technol. 2004 Dec 1;38(23):6377-84 [15597895] Sci Total Environ. 2006 Jun 1;362(1-3):166-78 [16055169] Environ Sci Technol. 2006 Jun 1;40(11):3456-62 [16786680] Clin Pharmacol Ther. 2007 Feb;81(2):164-9 [17259943] Sci Total Environ. 2008 Jan 25;389(2-3):329-39 [17936335] Environ Toxicol Chem. 2008 Mar;27(3):535-41 [17983274] Environ Sci Technol. 2008 May 1;42(9):3407-14 [18522126] Environ Sci Technol. 2008 Oct 1;42(19):7046-54 [18939525] N Engl J Med. 2009 Feb 5;360(6):573-87 [19196674] Environ Sci Technol. 2009 Feb 1;43(3):597-603 [19244989] Endocr Rev. 2009 Jun;30(4):293-342 [19502515] Environ Health Perspect. 2009 Aug;117(8):A348-53 [19672388] Aquat Toxicol. 2009 Dec 13;95(4):330-8 [19747739] Environ Health Perspect. 2010 Mar;118(3):338-44 [20194073] Appl Microbiol Biotechnol. 2010 May;86(6):1671-92 [20354692] N Engl J Med. 2010 Jul 22;363(4):301-4 [20551152] Environ Toxicol Chem. 2009 Dec;28(12):2725-32 [19645524] Environ Pollut. 2010 Nov;158(11):3372-7 [20817369] Environ Sci Technol. 2011 Jan 1;45(1):51-60 [20977246] Environ Health Perspect. 2011 Aug;119(8):1142-8 [21543282] Environ Sci Technol. 2011 Sep 1;45(17):7605; author reply 7606-7 [21838254] Expert Rev Clin Pharmacol. 2011 Mar;4(2):211-32 [22115404] Integr Environ Assess Manag. 2012 Jan;8(1):135-66 [21913321] Environ Sci Technol. 2012 Feb 21;46(4):2121-31 [22300164] Chemosphere. 2012 Apr;87(5):521-6 [22245058] Environ Pollut. 2012 May;164:28-35 [22318008] Environ Health Perspect. 2012 Apr;120(4):A143-4 [22470049] Rev Environ Contam Toxicol. 2012;218:1-99 [22488604] Environ Toxicol Chem. 2012 Jun;31(6):1407-15 [22488655] Environ Toxicol Chem. 2012 Jun;31(6):1396-406 [22488680] AAPS J. 2012 Sep;14(3):473-80 [22528508] Regul Toxicol Pharmacol. 2012 Oct;64(1):130-3 [22750031] Endocrinology. 2012 Sep;153(9):4097-110 [22733974] Environ Health Perspect. 2012 Sep;120(9):1221-9 [22647657] Prog Mol Biol Transl Sci. 2012;112:231-58 [22974742] Environ Pollut. 2013 Jul;178:271-7 [23587857] Int J Med Microbiol. 2013 Aug;303(6-7):293-7 [23517688] Environ Pollut. 2014 Jan;184:354-9 [24095705] AAPS J. 2012 Dec;14(4):703-13 [22798021] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1208/s12248-014-9561-3 ER - TY - JOUR T1 - A randomized and controlled clinical trial of two different compositions of deproteinized bovine bone and autogenous bone used for lateral ridge augmentation AN - 1500760847; 19158385 AB - The aim of the study was to radiologically and histologically evaluate the graft healing and volumetric changes after lateral augmentation with two different compositions of deproteinized bovine bone (DPBB) and autogenous bone (AB). Thirteen patients with a mean age of 59.6 plus or minus 12.1 years (six men and seven women) were included in this randomized and controlled trial, designed as a split-mouth study. Ten edentulous and four partially edentulous jaws with an alveolar ridge width of less than or equal to 4 mm were laterally augmented with a graft composition of 60 : 40 (DPBB/AB) on one side and 90 : 10 (DPBB/AB) on the contralateral side. Cone beam computed tomography (CB/CT) was obtained immediately postoperatively and after a healing period of 7.5 months. Width changes were measured on CB/CT scans. After a mean healing period of 8.1 months (range, 7.9-8.3), biopsies were retrieved perpendicular to the crest from each graft by means of a trephine bur. Histomorphometry was performed, and the following variables were recorded: Ingrowth of new bone (percentage of total graft width), percentage of DPBB, bone and soft tissue, and percentage of DPBB particles in contact with bone. The mean gained width of the alveolar crest after 7.5 months was significantly more for the 60 : 40 mixture compared with the 90 : 10 mixture, 3.5 ( plus or minus 1.3) mm and 2.9 ( plus or minus 1.3) mm, respectively. There was a significant difference in graft width reduction between 60 : 40 and 90 : 10 after 7.5 months, 37 ( plus or minus 19.9)% and 46.9 ( plus or minus 23.5)%, respectively. New bone ingrowth had occurred in 82.1 ( plus or minus 23.3)% and 82.3 ( plus or minus 26.6)% of the graft, respectively. There were no statistical differences between fractions of different tissues between the 90 : 10 and 60 : 40 compositions. However, there were significantly more soft tissue and less new bone formation closer to the periosteum compared with the graft portion closer to the residual bone in both 60 : 40 and 90 : 10 compositions. There was significantly less graft width reduction with a mixture of 60 : 40 (DPBB/AB) compared with a mixture of 90 : 10 composition, but the results from the histomorphometry showed no statistical differences comparing the groups. JF - Clinical Oral Implants Research AU - Mordenfeld, Arne AU - Johansson, Carina B AU - Albrektsson, Tomas AU - Hallman, Mats AD - Department of Oral & Maxillofacial Surgery. Public Health Service Y1 - 2014/03// PY - 2014 DA - Mar 2014 SP - 310 EP - 320 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 25 IS - 3 SN - 0905-7161, 0905-7161 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Age KW - Bone grafts KW - W 30920:Tissue Engineering KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500760847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Oral+Implants+Research&rft.atitle=A+randomized+and+controlled+clinical+trial+of+two+different+compositions+of+deproteinized+bovine+bone+and+autogenous+bone+used+for+lateral+ridge+augmentation&rft.au=Mordenfeld%2C+Arne%3BJohansson%2C+Carina+B%3BAlbrektsson%2C+Tomas%3BHallman%2C+Mats&rft.aulast=Mordenfeld&rft.aufirst=Arne&rft.date=2014-03-01&rft.volume=25&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=Clinical+Oral+Implants+Research&rft.issn=09057161&rft_id=info:doi/10.1111%2Fclr.12143 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Bone grafts DO - http://dx.doi.org/10.1111/clr.12143 ER - TY - JOUR T1 - Towards quantitation of the effects of renal impairment and probenecid inhibition on kidney uptake and efflux transporters, using physiologically based pharmacokinetic modelling and simulations. AN - 1500703029; 24214317 AB - The kidney is a major drug-eliminating organ. Renal impairment or concomitant use of transporter inhibitors may decrease active secretion and increase exposure to a drug that is a substrate of kidney secretory transporters. However, prediction of the effects of patient factors on kidney transporters remains challenging because of the multiplicity of transporters and the lack of understanding of their abundance and specificity. The objective of this study was to use physiologically based pharmacokinetic (PBPK) modelling to evaluate the effects of patient factors on kidney transporters. Models for three renally cleared drugs (oseltamivir carboxylate, cidofovir and cefuroxime) were developed using a general PBPK platform, with the contributions of net basolateral uptake transport (T up,b) and apical efflux transport (T eff,a) being specifically defined. We demonstrated the practical use of PBPK models to: (1) define transporter-mediated renal secretion, using plasma and urine data; (2) inform a change in the system-dependent parameter (≥10-fold reduction in the functional 'proximal tubule cells per gram kidney') in severe renal impairment that is responsible for the decreased secretory transport activities of test drugs; (3) derive an in vivo, plasma unbound inhibition constant of T up,b by probenecid (≤1 μM), based on observed drug interaction data; and (4) suggest a plausible mechanism of probenecid preferentially inhibiting T up,b in order to alleviate cidofovir-induced nephrotoxicity. JF - Clinical pharmacokinetics AU - Hsu, Vicky AU - de L T Vieira, Manuela AU - Zhao, Ping AU - Zhang, Lei AU - Zheng, Jenny Huimin AU - Nordmark, Anna AU - Berglund, Eva Gil AU - Giacomini, Kathleen M AU - Huang, Shiew-Mei AD - Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Avenue, Silver Spring, MD, 20993, USA. Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 283 EP - 293 VL - 53 IS - 3 KW - Membrane Transport Proteins KW - 0 KW - Pharmaceutical Preparations KW - Renal Agents KW - Probenecid KW - PO572Z7917 KW - Index Medicus KW - Animals KW - Computer Simulation KW - Humans KW - Models, Biological KW - Kidney Diseases -- metabolism KW - Pharmaceutical Preparations -- metabolism KW - Kidney -- metabolism KW - Probenecid -- antagonists & inhibitors KW - Membrane Transport Proteins -- metabolism KW - Renal Agents -- antagonists & inhibitors KW - Pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500703029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+pharmacokinetics&rft.atitle=Towards+quantitation+of+the+effects+of+renal+impairment+and+probenecid+inhibition+on+kidney+uptake+and+efflux+transporters%2C+using+physiologically+based+pharmacokinetic+modelling+and+simulations.&rft.au=Hsu%2C+Vicky%3Bde+L+T+Vieira%2C+Manuela%3BZhao%2C+Ping%3BZhang%2C+Lei%3BZheng%2C+Jenny+Huimin%3BNordmark%2C+Anna%3BBerglund%2C+Eva+Gil%3BGiacomini%2C+Kathleen+M%3BHuang%2C+Shiew-Mei&rft.aulast=Hsu&rft.aufirst=Vicky&rft.date=2014-03-01&rft.volume=53&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Clinical+pharmacokinetics&rft.issn=1179-1926&rft_id=info:doi/10.1007%2Fs40262-013-0117-y LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-12-08 N1 - Date created - 2014-02-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Antimicrob Agents Chemother. 1976 May;9(5):741-7 [949172] Contrib Nephrol. 1979;16:109-14 [467060] Drug Metab Dispos. 2002 Jan;30(1):13-9 [11744606] Eur J Pharmacol. 2001 May 11;419(2-3):113-20 [11426832] J Clin Pharmacol. 2012 Apr;52(4):530-42 [21505084] J Clin Pharmacol. 2012 Jan;52(1 Suppl):91S-108S [22232759] Expert Rev Clin Pharmacol. 2011 Mar;4(2):261-74 [22115405] Clin Pharmacokinet. 2011 Sep;50(9):613-23 [21827216] J Med Chem. 2009 Aug 13;52(15):4844-52 [19445515] Drug Metab Pharmacokinet. 2009;24(1):53-75 [19252336] J Pharmacol Exp Ther. 2007 May;321(2):673-83 [17314201] J Pharm Sci. 2006 Jun;95(6):1238-57 [16639716] Kidney Int. 2006 Jan;69(2):213-7 [16408108] Kidney Int. 2005 Dec;68(6):2704-13 [16316345] J Pharm Sci. 2005 Jun;94(6):1259-76 [15858854] Clin Pharmacokinet. 1999 Feb;36(2):127-43 [10092959] Am J Physiol. 1999 Feb;276(2 Pt 2):F191-8 [9950949] Clin Pharmacol Ther. 1999 Jan;65(1):21-8 [9951427] J Antimicrob Chemother. 1997 Dec;40(6):903-6 [9462447] Am J Kidney Dis. 1996 Jun;27(6):765-75 [8651239] Kidney Int. 1995 Jun;47(6):1546-57 [7643523] Am J Nephrol. 1993;13(5):385-98 [8116691] Am J Pathol. 1989 Oct;135(4):719-33 [2801886] Antimicrob Agents Chemother. 1981 Mar;19(3):443-9 [7247369] Drug Metab Dispos. 2004 Oct;32(10):1096-102 [15377641] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s40262-013-0117-y ER - TY - JOUR T1 - Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. AN - 1500692057; 24292225 AB - Zidovudine (3'-azido-3'-deoxythymidine; AZT) is the most widely used nucleoside reverse transcriptase inhibitor for the treatment of AIDS patients and prevention of mother-to-child transmission of HIV-1. Previously, we demonstrated that AZT had significantly greater growth inhibitory effects upon the human liver carcinoma cell line HepG2 as compared to the immortalized human liver cell line THLE2. We have now used gene expression profiling to determine the molecular pathways associated with toxicity in both cell lines. HepG2 cells were incubated with 0, 2, 20, or 100 μM AZT for 2 weeks; THLE2 cells were treated with 0, 50, 500, or 2,500 μM AZT, concentrations that were equi-toxic to those used in the HepG2 cells. After the treatment, total RNA was isolated and subjected to microarray analysis. Global analysis of gene expression, with a false discovery rate ≤0.01 and a fold change ≥1.5, indicated that 6- to 70-fold more genes were differentially expressed in a significant concentration-dependent manner in HepG2 cells when compared to THLE2 cells. Comparative analysis indicated that 7 % of these genes were common to both cell lines. Among the common differentially expressed genes, 70 % changed in the same direction, most of which were associated with cell death and survival, cell cycle, cell growth and proliferation, and DNA replication, recombination, and repair. As determined by the uptake of [methyl-(3)H]AZT, the intracellular levels of total AZT were approximately twofold higher in THLE2 cells than in HepG2 cells. The expression of thymidine kinase 1 (TK1) and UDP-glucuronosyltransferase 2B7 (UGT2B7) genes that regulate the metabolic activation and deactivation of AZT, respectively, was increased in HepG2 cells but decreased in THLE2 cells after treatment with AZT. This differential response in AZT metabolism was confirmed by real-time PCR, western blotting, and/or enzymatic assays. These data indicate that molecular pathways involved with cell death and survival, cell cycle, cell growth and proliferation, and DNA replication, recombination, and repair are involved in the toxicities associated with AZT in both human cell lines, and that the difference in expression of TK1 and UGT2B7 in response to AZT treatment in HepG2 cells and THLE2 cells might explain why HepG2 cells are more sensitive than THLE2 cells to the toxicity of AZT. JF - Archives of toxicology AU - Fang, Jia-Long AU - Han, Tao AU - Wu, Qiangen AU - Beland, Frederick A AU - Chang, Ching-Wei AU - Guo, Lei AU - Fuscoe, James C AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, 72079, USA, jia-long.fang@fda.hhs.gov. Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 609 EP - 623 VL - 88 IS - 3 KW - Anti-HIV Agents KW - 0 KW - Zidovudine KW - 4B9XT59T7S KW - UGT2B7 protein, human KW - EC 2.4.1.- KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Thymidine Kinase KW - EC 2.7.1.21 KW - thymidine kinase 1 KW - Index Medicus KW - Glucuronosyltransferase -- genetics KW - Dose-Response Relationship, Drug KW - Humans KW - Anti-HIV Agents -- pharmacology KW - Thymidine Kinase -- metabolism KW - Glucuronosyltransferase -- metabolism KW - Hep G2 Cells -- drug effects KW - Cell Line KW - Thymidine Kinase -- genetics KW - Hepatocytes -- drug effects KW - Zidovudine -- metabolism KW - Zidovudine -- pharmacology KW - Gene Expression Regulation -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500692057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+toxicology&rft.atitle=Differential+gene+expression+in+human+hepatocyte+cell+lines+exposed+to+the+antiretroviral+agent+zidovudine.&rft.au=Fang%2C+Jia-Long%3BHan%2C+Tao%3BWu%2C+Qiangen%3BBeland%2C+Frederick+A%3BChang%2C+Ching-Wei%3BGuo%2C+Lei%3BFuscoe%2C+James+C&rft.aulast=Fang&rft.aufirst=Jia-Long&rft.date=2014-03-01&rft.volume=88&rft.issue=3&rft.spage=609&rft.isbn=&rft.btitle=&rft.title=Archives+of+toxicology&rft.issn=1432-0738&rft_id=info:doi/10.1007%2Fs00204-013-1169-3 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-05-12 N1 - Date created - 2014-02-18 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1007/s00204-013-1169-3 ER - TY - JOUR T1 - Effect of uremic serum and uremic toxins on drug metabolism in human microsomes. AN - 1499155865; 24184159 AB - There is increasing evidence that renal impairment modifies nonrenal drug clearance through drug metabolizing cytochrome P450 (CYP) enzymes. In this study, the direct inhibitory effect of serum from chronic renal failure (CRF) patients receiving dialysis was evaluated in CYP3A4 (testosterone) and CYP2B6 (bupropion) metabolism assays. Human liver microsomes were incubated with ultrafiltered serum collected pre- and post-hemodialysis from ten CRF patients. Additionally, several uremic toxins were evaluated in the CYP3A4 assay. In only three patients was there a significant decrease or increase in testosterone or bupropion metabolism post-dialysis. Urea, mannitol, guanidine, homocysteine, uridine and creatinine had no effect on CYP3A4 metabolism. CMPF, hippuric acid and p-cresol had IC50 values that fell within CRF patient plasma concentrations. The IC50 values for indoxyl sulfate and indole-3-acetic acid were greater than CRF plasma concentrations. The lack of a consistent effect on CYP3A4 or CYP2B6 metabolism by uremic serum may be due in part to the frequency of hemodialysis in these patients which reduced the accumulation of uremic toxins. CMPF, hippuric acid and p-cresol have the ability to inhibit CYP3A4 metabolism at clinical concentrations which may correspond to reports of changes in hepatic metabolism in some CRF patients. Published by Elsevier Inc. JF - Regulatory toxicology and pharmacology : RTP AU - Volpe, Donna A AU - Tobin, Grainne A AU - Tavakkoli, Fatemeh AU - Dowling, Thomas C AU - Light, Paul D AU - Parker, Robert J AD - Division of Drug Safety Research, Food and Drug Administration, Silver Spring, MD, USA. Electronic address: donna.volpe@fda.hhs.gov. ; Division of Drug Safety Research, Food and Drug Administration, Silver Spring, MD, USA. ; School of Pharmacy, University of Maryland, Baltimore, MD, USA. ; School of Medicine, University of Maryland, Baltimore, MD, USA. Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 297 EP - 303 VL - 68 IS - 2 KW - Toxins, Biological KW - 0 KW - Bupropion KW - 01ZG3TPX31 KW - Testosterone KW - 3XMK78S47O KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP2B6 protein, human KW - Cytochrome P-450 CYP2B6 KW - Cytochrome P-450 CYP3A KW - Index Medicus KW - Chronic renal failure KW - Uremic toxins KW - Uremic serum KW - Metabolism KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Testosterone -- metabolism KW - Humans KW - Cytochrome P-450 CYP3A -- metabolism KW - Adult KW - Kidney Failure, Chronic -- therapy KW - Bupropion -- metabolism KW - Middle Aged KW - Male KW - Female KW - Toxins, Biological -- metabolism KW - Microsomes, Liver -- metabolism KW - Renal Dialysis KW - Uremia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499155865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.atitle=Effect+of+uremic+serum+and+uremic+toxins+on+drug+metabolism+in+human+microsomes.&rft.au=Volpe%2C+Donna+A%3BTobin%2C+Grainne+A%3BTavakkoli%2C+Fatemeh%3BDowling%2C+Thomas+C%3BLight%2C+Paul+D%3BParker%2C+Robert+J&rft.aulast=Volpe&rft.aufirst=Donna&rft.date=2014-03-01&rft.volume=68&rft.issue=2&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=Regulatory+toxicology+and+pharmacology+%3A+RTP&rft.issn=1096-0295&rft_id=info:doi/10.1016%2Fj.yrtph.2013.10.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-18 N1 - Date created - 2014-02-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.yrtph.2013.10.006 ER - TY - JOUR T1 - Clinical pharmacology research strategy for dissolvable tobacco products. AN - 1499151950; 24253379 AB - Dissolvable tobacco products (DTPs) are relatively new to the market. Some researchers and manufacturers describe them as finely ground tobacco that has been compressed into sticks, strips, and orbs that dissolve or disintegrate in the mouth and do not require spitting. While the pharmacokinetic profiles of nicotine and other tobacco-associated compounds and pharmacological effects of these products are complex, their clinical pharmacology has not been systematically evaluated. We reviewed the scientific literature regarding the known pharmacokinetic (PK) characteristics and pharmacodynamic (PD) effects of DTPs with the purpose of identifying research gaps and informing future studies. To evaluate current knowledge of the pharmacological properties of DTPs; to assess their similarities and differences with other tobacco products, especially smokeless tobacco products, and Food and Drug Administration-approved nicotine replacement therapies; to identify gaps in existing information; and to propose a strategy for future clinical pharmacology studies of DTPs. We reviewed the peer-reviewed literature and generated research questions for future clinical pharmacology studies. Data on the PK and PD of DTPs are sparse and inconsistent. The results of existing studies are limited and inconclusive, and their interpretation is complicated by methodological and/or study design issues. This review identifies a need for larger, comprehensive, and prospectively designed studies that include PK/PD measurements and data analyses. We propose a research agenda for future DTP studies related to the clinical pharmacology of nicotine, its metabolites, tobacco-specific nitrosamines, and other toxic compounds. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Mishina, Elena V AU - Hoffman, Allison C AD - Office of Science, Center for Tobacco Products, Food and Drug Administration, Rockville, MD. Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 253 EP - 262 VL - 16 IS - 3 KW - Index Medicus KW - United States KW - Humans KW - Clinical Trials as Topic KW - Pharmacokinetics KW - Tobacco, Smokeless -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499151950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Clinical+pharmacology+research+strategy+for+dissolvable+tobacco+products.&rft.au=Mishina%2C+Elena+V%3BHoffman%2C+Allison+C&rft.aulast=Mishina&rft.aufirst=Elena&rft.date=2014-03-01&rft.volume=16&rft.issue=3&rft.spage=253&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=1469-994X&rft_id=info:doi/10.1093%2Fntr%2Fntt182 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-22 N1 - Date created - 2014-02-12 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/ntr/ntt182 ER - TY - JOUR T1 - The role of bile salt export pump gene repression in drug-induced cholestatic liver toxicity. AN - 1493795210; 24335466 AB - The bile salt export pump (BSEP, ABCB11) is predominantly responsible for the efflux of bile salts, and disruption of BSEP function is often associated with altered hepatic homeostasis of bile acids and cholestatic liver injury. Accumulating evidence suggests that many drugs can cause cholestasis through interaction with hepatic transporters. To date, a relatively strong association between drug-induced cholestasis and attenuated BSEP activity has been proposed. However, whether repression of BSEP transcription would contribute to drug-induced cholestasis is largely unknown. In this study, we selected 30 drugs previously reported as BSEP inhibitors to evaluate their effects on BSEP expression, farnesoid X receptor (FXR) activation, and correlations to clinically reported liver toxicity. Our results indicate that of the 30 BSEP inhibitors, five exhibited potent repression of BSEP expression (≥60% repression), ten were moderate repressors (20-60% repression), whereas others had negligible effects (≤20% repression). Of importance, two drugs (troglitazone and benzbromarone), previously withdrawn from the market because of liver injury, are among the potent repressors. Further investigation of the five potent repressors revealed that transcriptional repression of BSEP by lopinavir and troglitazone may occur through their interaction with FXR, whereas others are via FXR-independent yet unidentified pathways. Our data suggest that in addition to functional inhibition, repression of BSEP expression may play an important role in drug-induced cholestatic liver toxicity. Thus, a combination of the two would reveal a more accurate prediction of drug-induced cholestasis than does either repression or inhibition alone. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Garzel, Brandy AU - Yang, Hui AU - Zhang, Lei AU - Huang, Shiew-Mei AU - Polli, James E AU - Wang, Hongbing AD - Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore Maryland (B.G., H.Y., J.E.P., H.W.) and Office of Clinical Pharmacology, Office of Translational Sciences, CDER, Food and Drug Administration, Silver Spring, Maryland (L.Z., S.H.). Y1 - 2014/03// PY - 2014 DA - March 2014 SP - 318 EP - 322 VL - 42 IS - 3 KW - ABCB11 protein, human KW - 0 KW - Pharmaceutical Preparations KW - Receptors, Cytoplasmic and Nuclear KW - farnesoid X-activated receptor KW - Index Medicus KW - Hep G2 Cells KW - Cells, Cultured KW - Humans KW - Primary Cell Culture KW - Receptors, Cytoplasmic and Nuclear -- genetics KW - Predictive Value of Tests KW - Pharmaceutical Preparations -- analysis KW - Gene Expression -- drug effects KW - Hepatocytes -- drug effects KW - Chemical and Drug Induced Liver Injury -- complications KW - Cholestasis -- etiology KW - Chemical and Drug Induced Liver Injury -- genetics KW - ATP-Binding Cassette Transporters -- genetics KW - Cholestasis -- genetics KW - ATP-Binding Cassette Transporters -- antagonists & inhibitors KW - Hepatocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1493795210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=The+role+of+bile+salt+export+pump+gene+repression+in+drug-induced+cholestatic+liver+toxicity.&rft.au=Garzel%2C+Brandy%3BYang%2C+Hui%3BZhang%2C+Lei%3BHuang%2C+Shiew-Mei%3BPolli%2C+James+E%3BWang%2C+Hongbing&rft.aulast=Garzel&rft.aufirst=Brandy&rft.date=2014-03-01&rft.volume=42&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=1521-009X&rft_id=info:doi/10.1124%2Fdmd.113.054189 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-26 N1 - Date created - 2014-01-30 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2012 Jan;40(1):130-8 [21965623] Toxicol Appl Pharmacol. 2013 Apr 1;268(1):79-89 [23360887] Clin Pharmacol Ther. 2001 Apr;69(4):223-31 [11309550] Physiol Rev. 2001 Jul;81(3):1269-304 [11427696] J Biol Chem. 2001 Aug 3;276(31):28857-65 [11387316] Toxicol Sci. 2003 Nov;76(1):220-8 [12944587] Methods Mol Biol. 2005;290:207-29 [15361665] Am J Physiol. 1976 Sep;231(3):734-42 [788526] Cancer Res. 1995 May 15;55(10):2029-34 [7538046] Nat Genet. 1998 Mar;18(3):219-24 [9500542] Science. 1999 May 21;284(5418):1362-5 [10334992] J Clin Gastroenterol. 2005 Apr;39(4 Suppl 2):S83-9 [15758665] Hepatology. 2005 Aug;42(2):481-9 [16025496] J Pharmacol Exp Ther. 2006 Apr;317(1):317-25 [16371446] J Pharmacol Exp Ther. 2006 Jun;317(3):1200-9 [16513849] J Lipid Res. 2008 May;49(5):973-84 [18270374] World J Gastroenterol. 2008 Oct 7;14(37):5641-9 [18837079] J Pharmacol Exp Ther. 2009 Jul;330(1):125-34 [19369578] Curr Opin Lipidol. 2009 Jun;20(3):176-81 [19684528] Hepatology. 2009 Nov;50(5):1588-96 [19821532] Drug Metab Rev. 2010 Aug;42(3):446-71 [20109035] Toxicol Sci. 2010 Dec;118(2):485-500 [20829430] Drug Discov Today. 2011 Aug;16(15-16):697-703 [21624500] Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):313-7 [22108051] J Pharmacol Exp Ther. 2012 Mar;340(3):688-97 [22171088] Curr Protoc Toxicol. 2012 Nov;Chapter 23:Unit 23.5 [23169270] Clin Res Hepatol Gastroenterol. 2012 Dec;36(6):536-53 [22795478] Blood. 2013 Jan 10;121(2):329-38 [23160467] Mol Cell. 2000 Sep;6(3):507-15 [11030331] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1124/dmd.113.054189 ER - TY - CPAPER T1 - Comparison Of Total Protein Profile Of Alternaria Alternata Extract Obtained From Various U.S. Allergenic Extract Manufacturers T2 - 2014 Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI 2014) AN - 1518614190; 6283839 JF - 2014 Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI 2014) AU - Slater, Jay AU - Zoch, Allison AU - Newman- Gerhardt, Shoshana AU - Khurana, Taruna Y1 - 2014/02/28/ PY - 2014 DA - 2014 Feb 28 KW - USA KW - Proteins KW - Alternaria alternata UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518614190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Meeting+of+the+American+Academy+of+Allergy%2C+Asthma+and+Immunology+%28AAAAI+2014%29&rft.atitle=Comparison+Of+Total+Protein+Profile+Of+Alternaria+Alternata+Extract+Obtained+From+Various+U.S.+Allergenic+Extract+Manufacturers&rft.au=Slater%2C+Jay%3BZoch%2C+Allison%3BNewman-+Gerhardt%2C+Shoshana%3BKhurana%2C+Taruna&rft.aulast=Slater&rft.aufirst=Jay&rft.date=2014-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Meeting+of+the+American+Academy+of+Allergy%2C+Asthma+and+Immunology+%28AAAAI+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Announcements/am14-final-prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - CPAPER T1 - Development and Characterization Of a Murine Model Of Repeated Dry Exposure To Aerosolized Fungal Conidia T2 - 2014 Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI 2014) AN - 1518613858; 6283844 JF - 2014 Annual Meeting of the American Academy of Allergy, Asthma and Immunology (AAAAI 2014) AU - Nayak, Ajay AU - Buskirk, Amanda AU - Goldsmith, W AU - Lemons, Angela AU - Hettick, Justin AU - Kashon, Michael AU - Cumpston, Amy AU - Cumpston, Jared AU - Leonard, Howard AU - McKinney, Walter AU - Frazer, David AU - Beezhold, Donald AU - Green, Brett Y1 - 2014/02/28/ PY - 2014 DA - 2014 Feb 28 KW - Animal models KW - Conidia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1518613858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Meeting+of+the+American+Academy+of+Allergy%2C+Asthma+and+Immunology+%28AAAAI+2014%29&rft.atitle=Development+and+Characterization+Of+a+Murine+Model+Of+Repeated+Dry+Exposure+To+Aerosolized+Fungal+Conidia&rft.au=Nayak%2C+Ajay%3BBuskirk%2C+Amanda%3BGoldsmith%2C+W%3BLemons%2C+Angela%3BHettick%2C+Justin%3BKashon%2C+Michael%3BCumpston%2C+Amy%3BCumpston%2C+Jared%3BLeonard%2C+Howard%3BMcKinney%2C+Walter%3BFrazer%2C+David%3BBeezhold%2C+Donald%3BGreen%2C+Brett&rft.aulast=Nayak&rft.aufirst=Ajay&rft.date=2014-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Meeting+of+the+American+Academy+of+Allergy%2C+Asthma+and+Immunology+%28AAAAI+2014%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Announcements/am14-final-prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-23 N1 - Last updated - 2014-04-24 ER - TY - JOUR T1 - Early modulation of the transcription factor Nrf2 in rodent striatal slices by quinolinic acid, a toxic metabolite of the kynurenine pathway. AN - 1494302001; 24361737 AB - Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a transcription factor involved in the orchestration of antioxidant responses. Although its pharmacological activation has been largely hypothesized as a promising tool to ameliorate the progression of neurodegenerative events, the actual knowledge about its modulation in neurotoxic paradigms remains scarce. In this study, we investigated the early profile of Nrf2 modulation in striatal slices of rodents incubated in the presence of the toxic kynurenine pathway metabolite, quinolinic acid (QUIN). Tissue slices from rats and mice were obtained and used throughout the experiments in order to compare inter-species responses. Nuclear Nrf2 protein levels and oxidative damage to lipids were compared. Time- and concentration-response curves of all markers were explored. Nrf2 nuclear activation was corroborated through phase 2 antioxidant protein expression. The effects of QUIN on Nrf2 modulation and oxidative stress were also compared between slices of wild-type (Nrf2(+/+)) and Nrf2 knock-out (Nrf2(-/-)) mice. The possible involvement of the N-methyl-d-aspartate receptor (NMDAr) in the Nrf2 modulation and lipid peroxidation was further explored in mice striatal slices. In rat striatal slices, QUIN stimulated the Nrf2 nuclear translocation. This effect was accompanied by augmented lipid peroxidation. In the mouse striatum, QUIN per se exerted an induction of Nrf2 factor only at 1h of incubation, and a concentration-response effect on lipid peroxidation after 3h of incubation. QUIN stimulated the striatal content of phase 2 enzymes. Nrf2(-/-) mice were slightly more responsive than Nrf2(+/+) mice to the QUIN-induced oxidative damage, and completely unresponsive to the NMDAr antagonist MK-801 when tested against QUIN. Findings of this study indicate that: (1) Nrf2 is modulated in rodent striatal tissue in response to QUIN; (2) Nrf2(-/-) striatal tissue was moderately more vulnerable to oxidative damage than the Wt condition; and (3) early Nrf2 up-regulation reflects a compensatory response to the QUIN-induced oxidative stress in course as part of a general defense system, whereas Nrf2 down-regulation might contribute to more intense oxidative cell damage. Copyright © 2013 IBRO. All rights reserved. JF - Neuroscience AU - Colín-González, A L AU - Luna-López, A AU - Königsberg, M AU - Ali, S F AU - Pedraza-Chaverrí, J AU - Santamaría, A AD - Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, S.S.A., Mexico City, Mexico. ; Instituto Nacional de Geriatría, S.S.A., Mexico City, Mexico. ; Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana Iztapalapa, Mexico City, Mexico. ; Division of Neurotoxicology, National Center for Toxicological Research, FDA, Jefferson, AR, USA. ; Departamento de Biología, Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico. ; Laboratorio de Aminoácidos Excitadores, Instituto Nacional de Neurología y Neurocirugía, S.S.A., Mexico City, Mexico. Electronic address: absada@yahoo.com. Y1 - 2014/02/28/ PY - 2014 DA - 2014 Feb 28 SP - 130 EP - 139 VL - 260 KW - NF-E2-Related Factor 2 KW - 0 KW - Nfe2l2 protein, mouse KW - Nfe2l2 protein, rat KW - Kynurenine KW - 343-65-7 KW - Quinolinic Acid KW - F6F0HK1URN KW - Index Medicus KW - N-methyl-d-aspartate receptor KW - Huntington’s disease KW - ROS KW - thiobarbituric acid reactive substances KW - nicotinamide adenine dinucleotide phosphate-oxidase KW - Nrf2 KW - antioxidant defense KW - HO-1 KW - tert-butylhydroquinone KW - ethylenediaminetetraacetic acid KW - NMDAr KW - DMF KW - MDA KW - kynurenine pathway KW - NAD(P)H KW - excitotoxicity KW - EDTA KW - ethylene glycol tetraacetic acid KW - dizocilpine KW - QUIN KW - heme oxygenase-1 KW - antioxidant response element KW - malondialdehyde KW - KP KW - TBARS KW - Kynurenine pathway KW - HD KW - SAC KW - EGTA KW - ARE KW - reactive oxygen species KW - S-allyl cysteine KW - γ-GCL-C KW - gamma-glutamylcysteine ligase-C KW - SOD KW - Nuclear factor (erythroid-derived 2)-like 2 KW - oxidative stress KW - MK-801 KW - HEPES KW - dimethylfumarate KW - tBHQ KW - quinolinic acid KW - superoxide dismutase KW - hydroxyethyl piperazineethanesulfonic acid KW - Rats KW - Animals KW - Humans KW - Rats, Wistar KW - Mice, Inbred C57BL KW - Lipid Peroxidation -- drug effects KW - Kynurenine -- metabolism KW - Mice KW - Male KW - Female KW - Oxidative Stress -- physiology KW - Corpus Striatum -- metabolism KW - Corpus Striatum -- drug effects KW - Quinolinic Acid -- toxicity KW - NF-E2-Related Factor 2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1494302001?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Early+modulation+of+the+transcription+factor+Nrf2+in+rodent+striatal+slices+by+quinolinic+acid%2C+a+toxic+metabolite+of+the+kynurenine+pathway.&rft.au=Col%C3%ADn-Gonz%C3%A1lez%2C+A+L%3BLuna-L%C3%B3pez%2C+A%3BK%C3%B6nigsberg%2C+M%3BAli%2C+S+F%3BPedraza-Chaverr%C3%AD%2C+J%3BSantamar%C3%ADa%2C+A&rft.aulast=Col%C3%ADn-Gonz%C3%A1lez&rft.aufirst=A&rft.date=2014-02-28&rft.volume=260&rft.issue=&rft.spage=130&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=1873-7544&rft_id=info:doi/10.1016%2Fj.neuroscience.2013.12.025 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-25 N1 - Date created - 2014-02-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.neuroscience.2013.12.025 ER - TY - JOUR T1 - Association between Maternal Serum Perfluoroalkyl Substances during Pregnancy and Maternal and Cord Thyroid Hormones: Taiwan Maternal and Infant Cohort Study AN - 1534851235; 20047042 AB - Background: Perfluoroalkyl substances (PFASs) are synthetic compounds that are widely used in industry and are often detectable in humans. In pregnant rats and their pups, PFASs can interfere with thyroid hormone homeostasis. In humans, maternal thyroid hormones supply the fetus throughout pregnancy, and thyroid hormones play a critical role in fetal growth and neurodevelopment. Objectives: We investigated the association between maternal PFAS exposure and thyroid hormone status in pregnant women and neonates. Methods: In a study of environmental exposure and health in Taiwan, we measured serum concentrations of nine PFASs and four thyroid hormones for 285 pregnant women in their third trimester, and also measured cord serum thyroid hormones for 116 neonates. Associations between maternal PFASs and maternal and cord thyroid hormones were examined in multiple linear regression models. Results: Perfluorohexanesulfonic acid concentrations were positively associated with maternal thyroid-stimulating hormone (TSH) levels. Pregnant women with higher levels of perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnDA), and perfluorododecanoic acid (PFDoDA) had lower free thyroxine (T4) and total T4 levels. For example, we estimated that maternal free T4 levels decreased 0.019 ng/dL (95% CI: -0.028, -0.009) with each nanogram per milliliter increase in maternal PFNA. Finally, maternal PFNA, PFUnDA, and PFDoDA levels were associated with lower cord total triiodothyronine (T3) and total T4 levels, and maternal perfluorodecanoic acid (PFDeA) was associated with lower cord total T3. Conclusions: Our results suggest that exposure to some PFASs during pregnancy may interfere with thyroid hormone homeostasis in pregnant women and fetuses. Citation: Wang Y, Rogan WJ, Chen PC, Lien GW, Chen HY, Tseng YC, Longnecker MP, Wang SL. 2014. Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan Maternal and Infant Cohort Study. Environ Health Perspect 122:529-534; http://dx.doi.org/10.1289/ehp.1306925 JF - Environmental Health Perspectives AU - Wang, Yan AU - Rogan, Walter J AU - Chen, Pau-Chung AU - Lien, Guang-Wen AU - Chen, Hsiao-Yen AU - Tseng, Ying-Chih AU - Longnecker, Matthew P AU - Wang, Shu-Li AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA Y1 - 2014/02/21/ PY - 2014 DA - 2014 Feb 21 SP - 529 EP - 534 PB - US Government Printing Office, Superintendent of Documents, P.O. Box 371954 Pittsburgh PA 15250-7954 United States VL - 122 IS - 5 SN - 0091-6765, 0091-6765 KW - Environment Abstracts; Health & Safety Science Abstracts KW - Rats KW - Taiwan KW - Thyroid KW - Neonates KW - Hormones KW - Fetuses KW - Pregnancy KW - Infants KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - ENA 02:Toxicology & Environmental Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1534851235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Association+between+Maternal+Serum+Perfluoroalkyl+Substances+during+Pregnancy+and+Maternal+and+Cord+Thyroid+Hormones%3A+Taiwan+Maternal+and+Infant+Cohort+Study&rft.au=Wang%2C+Yan%3BRogan%2C+Walter+J%3BChen%2C+Pau-Chung%3BLien%2C+Guang-Wen%3BChen%2C+Hsiao-Yen%3BTseng%2C+Ying-Chih%3BLongnecker%2C+Matthew+P%3BWang%2C+Shu-Li&rft.aulast=Wang&rft.aufirst=Yan&rft.date=2014-02-21&rft.volume=122&rft.issue=5&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.1306925 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-06-01 N1 - Last updated - 2015-05-13 N1 - SubjectsTermNotLitGenreText - Rats; Thyroid; Neonates; Hormones; Fetuses; Infants; Pregnancy; Taiwan DO - http://dx.doi.org/10.1289/ehp.1306925 ER - TY - JOUR T1 - Mortality rates in people dually infected with HIV-1/2 and those infected with either HIV-1 or HIV-2: a systematic review and meta-analysis AN - 1765969995; PQ0002559403 AB - Objective: As compared to HIV-1 infection, HIV-2 is less transmissible, disease progression is slower, and the mortality risk is lower. It has been suggested that HIV-2 infection inhibits the progression of HIV-1 in individuals dually infected by HIV-1 and HIV-2 (HIV-D). We examined whether the mortality rates in dually infected individuals differ from those in persons infected with either HIV-1 or HIV-2. Design: We conducted a systematic review and meta-analysis. Methods: Medline and Embase databases were searched for studies that reported the number of deaths and person-years of observation (PY) for at least two of the three HIV groups (i.e. HIV-1, HIV-2, and HIV-D). Meta-analyses were then performed with random-effects models, estimating combined mortality rate ratios (MRRs). Results: Of the 631 identified titles, six articles were included in the meta-analysis of HIV-D-infected individuals versus HIV-mono-infected persons, and seven were included in the analysis of HIV-1-mono-infected versus HIV-2-mono-infected individuals. The overall MRR of those infected with HIV-D versus HIV-1 was 1.11 [95% confidence interval (CI) 0.95-1.30]. The overall MRR of those infected with HIV-D versus HIV-2 was 1.81 (95% CI 1.43-2.30) and the MRR of those infected with HIV-1 versus HIV-2 was 1.86 (95% CI 1.44-2.39). Conclusion: HIV-2-mono-infected persons have a lower mortality rate than those mono-infected with HIV-1 and those with HIV-D. There is no evidence that HIV-2 delays progression to death in HIV-D-infected individuals. JF - AIDS AU - Prince, Puck D AU - Matser, Amy AU - van Tienen, Carla AU - Whittle, Hilton C AU - van der Loeff, Maarten F Schim AD - Cluster of Infectious Diseases, Amsterdam Public Health Service, Amsterdam, amatser@ggd.amsterdam.nl Y1 - 2014/02/20/ PY - 2014 DA - 2014 Feb 20 SP - 549 EP - 558 PB - Lippincott Williams & Wilkins, Inc, 530 Walnut Street Philadelphia PA 19106-3621 United States VL - 28 IS - 4 SN - 0269-9370, 0269-9370 KW - Health & Safety Science Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - HIV-1 KW - HIV-2 KW - HIV-dual KW - meta-analysis KW - mortality KW - systematic review KW - Mortality KW - Acquired immune deficiency syndrome KW - Infection KW - Models KW - Databases KW - Human immunodeficiency virus KW - Reviews KW - Risk factors KW - Human immunodeficiency virus 1 KW - Human immunodeficiency virus 2 KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1765969995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Mortality+rates+in+people+dually+infected+with+HIV-1%2F2+and+those+infected+with+either+HIV-1+or+HIV-2%3A+a+systematic+review+and+meta-analysis&rft.au=Prince%2C+Puck+D%3BMatser%2C+Amy%3Bvan+Tienen%2C+Carla%3BWhittle%2C+Hilton+C%3Bvan+der+Loeff%2C+Maarten+F+Schim&rft.aulast=Prince&rft.aufirst=Puck&rft.date=2014-02-20&rft.volume=28&rft.issue=4&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/10.1097%2F01.SPC.0000432532.87841.78 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-02-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Databases; Mortality; Risk factors; Reviews; Infection; Models; Acquired immune deficiency syndrome; Human immunodeficiency virus; Human immunodeficiency virus 1; Human immunodeficiency virus 2 DO - http://dx.doi.org/10.1097/01.SPC.0000432532.87841.78 ER - TY - JOUR T1 - Rapid turbidimetric detection of milk powder adulteration with plant proteins. AN - 1500699442; 24484379 AB - Development of assays to screen milk for economically motivated adulteration with foreign proteins has been stalled since 2008 due to strong international reactions to the melamine poisoning incident in China and the surveillance emphasis placed on low molecular weight nitrogen-rich adulterants. New screening assays are still needed to detect high molecular weight foreign protein adulterants and characterize this understudied potential risk. A rapid turbidimetric method was developed to screen milk powder for adulteration with insoluble plant proteins. Milk powder samples spiked with 0.03-3% by weight of soy, pea, rice, and wheat protein isolates were extracted in 96-well plates, and resuspended pellet solution absorbance was measured. Limits of detection ranged from 100 to 200 μg, or 0.1-0.2% of the sample weight, and adulterant pellets were visually apparent even at ∼0.1%. Extraction recoveries ranged from 25 to 100%. Assay sensitivity and simplicity indicate that it would be ideally suitable to rapidly screen milk samples in resource poor environments where adulteration with plant protein is suspected. JF - Journal of agricultural and food chemistry AU - Scholl, Peter F AU - Farris, Samantha M AU - Mossoba, Magdi M AD - Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration , 5100 Paint Branch Parkway, HFS-707, Room BE-006, College Park, Maryland 20740, United States. Y1 - 2014/02/19/ PY - 2014 DA - 2014 Feb 19 SP - 1498 EP - 1505 VL - 62 IS - 7 KW - Plant Proteins KW - 0 KW - Powders KW - Index Medicus KW - Animals KW - Cattle KW - Peas -- chemistry KW - Oryza -- chemistry KW - Soybeans -- chemistry KW - Powders -- chemistry KW - Triticum -- chemistry KW - Nephelometry and Turbidimetry -- methods KW - Plant Proteins -- analysis KW - Food Contamination -- analysis KW - Milk -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500699442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.atitle=Rapid+turbidimetric+detection+of+milk+powder+adulteration+with+plant+proteins.&rft.au=Scholl%2C+Peter+F%3BFarris%2C+Samantha+M%3BMossoba%2C+Magdi+M&rft.aulast=Scholl&rft.aufirst=Peter&rft.date=2014-02-19&rft.volume=62&rft.issue=7&rft.spage=1498&rft.isbn=&rft.btitle=&rft.title=Journal+of+agricultural+and+food+chemistry&rft.issn=1520-5118&rft_id=info:doi/10.1021%2Fjf405617f LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-07-15 N1 - Date created - 2014-02-19 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1021/jf405617f ER - TY - JOUR T1 - Hair mercury and urinary cadmium levels in Belgian children and their mothers within the framework of the COPHES/DEMOCOPHES projects. AN - 1492708403; 24333995 AB - A harmonized human biomonitoring pilot study was set up within the frame of the European projects DEMOCOPHES and COPHES. In 17 European countries, biomarkers of some environmental pollutants, including urinary cadmium and hair mercury, were measured in children and their mothers in order to obtain European-wide comparison values on these chemicals. The Belgian participant population consisted in 129 school children (6-11 years) and their mothers (≤ 45 years) living in urban or rural areas of Belgium. The geometric mean levels for mercury in hair were 0.383 μg/g and 0.204 μg/g for respectively mothers and children. Cadmium in mother's and children's urine was detected at a geometric mean concentration of respectively 0.21 and 0.04 μg/l. For both biomarkers, levels measured in the mothers and their child were correlated. While the urinary cadmium levels increased with age, no trend was found for hair mercury content, except the fact that mothers hold higher levels than children. The hair mercury content increased significantly with the number of dental amalgam fillings, explaining partially the higher levels in the mothers by their higher presence rate of these amalgams compared to children. Fish or seafood consumption was the other main parameter determining the mercury levels in hair. No relationship was found between smoking status and cadmium or mercury levels, but the studied population included very few smokers. Urinary cadmium levels were higher in both mothers and children living in urban areas, while for mercury this difference was only significant for children. Our small population showed urinary cadmium and hair mercury levels lower than the health based guidelines suggested by the WHO or the JECFA (Joint FAO/WHO Expert Committee on Food Additives). Only 1% had cadmium level slightly higher than the German HBM-I value (1 μg/l for adults), and 9% exceeded the 1 μg mercury/g hair suggested by the US EPA. Copyright © 2013 Elsevier B.V. All rights reserved. JF - The Science of the total environment AU - Pirard, Catherine AU - Koppen, Gudrun AU - De Cremer, Koen AU - Van Overmeire, Ilse AU - Govarts, Eva AU - Dewolf, Marie-Christine AU - Van De Mieroop, Els AU - Aerts, Dominique AU - Biot, Pierre AU - Casteleyn, Ludwine AU - Kolossa-Gehring, Marike AU - Schwedler, Gerda AU - Angerer, Jürgen AU - Koch, Holger M AU - Schindler, Birgit K AU - Castaño, Argelia AU - Esteban, Marta AU - Schoeters, Greet AU - Den Hond, Elly AU - Sepai, Ovnair AU - Exley, Karen AU - Horvat, Milena AU - Bloemen, Louis AU - Knudsen, Lisbeth E AU - Joas, Reinhard AU - Joas, Anke AU - Van Loco, Joris AU - Charlier, Corinne AD - CHU of Liege, Laboratory of Clinical, Forensic and Environmental Toxicology, CHU (B35), 4000 Liege, Belgium. Electronic address: c.pirard@chu.ulg.ac.be. ; Flemish Institute of Technological Research, Environmental Risk and Health Unit, Boeretang 200, 2400 Mol, Belgium. Electronic address: gudrun.koppen@vito.be. ; Scientific Institute of Public Health, Juliette Wytsmanstraat 14, 1050 Brussels, Belgium. Electronic address: Koen.DeCremer@wiv-isp.be. ; Scientific Institute of Public Health, Juliette Wytsmanstraat 14, 1050 Brussels, Belgium. Electronic address: ilse.vanovermeire@wiv-isp.be. ; Flemish Institute of Technological Research, Environmental Risk and Health Unit, Boeretang 200, 2400 Mol, Belgium. Electronic address: eva.govarts@vito.be. ; Provincial Institute Hainaut Vigilance Sanitaire - Hainaut Hygiène Publique en (HVS-HPH), Boulevard Sainctelette, 55, 7000 Mons, Belgium. Electronic address: marie_christine.dewolf@hainaut.be. ; Provincial Institute for Hygiene (PIH), Boomgaardstraat 22 bus 1, 2600 Antwerpen, Belgium. Electronic address: Els.VanDeMieroop@pih.provant.be. ; Federal Public Service Health, Food Chain Safety and Environment, Place Victor Horta 40/10, 1060 Brussels, Belgium. Electronic address: dominique.aerts@milieu.belgie.be. ; Federal Public Service Health, Food Chain Safety and Environment, Place Victor Horta 40/10, 1060 Brussels, Belgium. Electronic address: pierre.biot@environnement.belgique.be. ; University of Leuven, Center for Human Genetics, Herestraat 49, 3000 Leuven, Belgium. Electronic address: Ludwine.Casteleyn@med.kuleuven.be. ; Federal Environment Agency, Corrensplatz 1, 14195 Berlin, Germany. Electronic address: marike.kolossa@uba.de. ; Federal Environment Agency, Corrensplatz 1, 14195 Berlin, Germany. Electronic address: Gerda.Schwedler@uba.de. ; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. Electronic address: angerer@ipa-dguv.de. ; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. Electronic address: koch@ipa-dguv.de. ; Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-Universität Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789 Bochum, Germany. Electronic address: bt.schindler@googlemail.com. ; Instituto de Salud Carlos III (ISCIII), Ctra. Majadahonda - Pozuelo, Km. 2, 28220, Madrid, Spain. Electronic address: castano@isciii.es. ; Instituto de Salud Carlos III (ISCIII), Ctra. Majadahonda - Pozuelo, Km. 2, 28220, Madrid, Spain. Electronic address: m.esteban@isciii.es. ; Flemish Institute of Technological Research, Environmental Risk and Health Unit, Boeretang 200, 2400 Mol, Belgium. Electronic address: greet.schoeters@vito.be. ; Flemish Institute of Technological Research, Environmental Risk and Health Unit, Boeretang 200, 2400 Mol, Belgium. Electronic address: elly.denhond@vito.be. ; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Oxfordshire OX11 0RQ, United Kingdom. Electronic address: Ovnair.Sepai@phe.gov.uk. ; Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Oxfordshire OX11 0RQ, United Kingdom. Electronic address: Karen.Exley@phe.gov.uk. ; Jožef Stefan Institute, Jamova cesta 39, 1000 Ljubljana, Slovenia. Electronic address: milena.horvat@ijs.si. ; Environmental Health Science International, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands. Electronic address: lb@ehsi.eu. ; University of Copenhagen, Department of Public Health, Øster Farimagsgade 5, 1353 København, Denmark. Electronic address: like@sund.ku.dk. ; BiPRO GmbH, Grauertstrasse 12, 81545 Munich, Germany. Electronic address: reinhard.joas@bipro.de. ; BiPRO GmbH, Grauertstrasse 12, 81545 Munich, Germany. Electronic address: anke.joas@bipro.de. ; Scientific Institute of Public Health, Juliette Wytsmanstraat 14, 1050 Brussels, Belgium. Electronic address: Joris.VanLoco@wiv-isp.be. ; CHU of Liege, Laboratory of Clinical, Forensic and Environmental Toxicology, CHU (B35), 4000 Liege, Belgium. Electronic address: c.charlier@chu.ulg.ac.be. Y1 - 2014/02/15/ PY - 2014 DA - 2014 Feb 15 SP - 730 EP - 740 VL - 472 KW - Environmental Pollutants KW - 0 KW - Cadmium KW - 00BH33GNGH KW - Mercury KW - FXS1BY2PGL KW - Index Medicus KW - Urine KW - Human biomonitoring KW - Europe KW - Hair KW - Environmental Monitoring KW - Humans KW - Belgium KW - Seafood -- statistics & numerical data KW - Diet -- statistics & numerical data KW - Child KW - Male KW - Female KW - Environmental Pollutants -- metabolism KW - Mercury -- metabolism KW - Environmental Exposure -- statistics & numerical data KW - Cadmium -- urine KW - Hair -- metabolism KW - Environmental Exposure -- analysis KW - Environmental Pollutants -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492708403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Science+of+the+total+environment&rft.atitle=Hair+mercury+and+urinary+cadmium+levels+in+Belgian+children+and+their+mothers+within+the+framework+of+the+COPHES%2FDEMOCOPHES+projects.&rft.au=Pirard%2C+Catherine%3BKoppen%2C+Gudrun%3BDe+Cremer%2C+Koen%3BVan+Overmeire%2C+Ilse%3BGovarts%2C+Eva%3BDewolf%2C+Marie-Christine%3BVan+De+Mieroop%2C+Els%3BAerts%2C+Dominique%3BBiot%2C+Pierre%3BCasteleyn%2C+Ludwine%3BKolossa-Gehring%2C+Marike%3BSchwedler%2C+Gerda%3BAngerer%2C+J%C3%BCrgen%3BKoch%2C+Holger+M%3BSchindler%2C+Birgit+K%3BCasta%C3%B1o%2C+Argelia%3BEsteban%2C+Marta%3BSchoeters%2C+Greet%3BDen+Hond%2C+Elly%3BSepai%2C+Ovnair%3BExley%2C+Karen%3BHorvat%2C+Milena%3BBloemen%2C+Louis%3BKnudsen%2C+Lisbeth+E%3BJoas%2C+Reinhard%3BJoas%2C+Anke%3BVan+Loco%2C+Joris%3BCharlier%2C+Corinne&rft.aulast=Pirard&rft.aufirst=Catherine&rft.date=2014-02-15&rft.volume=472&rft.issue=&rft.spage=730&rft.isbn=&rft.btitle=&rft.title=The+Science+of+the+total+environment&rft.issn=1879-1026&rft_id=info:doi/10.1016%2Fj.scitotenv.2013.11.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-04 N1 - Date created - 2014-01-27 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.scitotenv.2013.11.028 ER - TY - CPAPER T1 - Genomic and Epigenomic Changes in the Liver and Kidney During the Rat Life Cycle T2 - 2014 Annual Meeting of the American Association for the Advancement of Science (AAAS 2014) AN - 1510095396; 6279917 JF - 2014 Annual Meeting of the American Association for the Advancement of Science (AAAS 2014) AU - Fuscoe, James Y1 - 2014/02/13/ PY - 2014 DA - 2014 Feb 13 KW - Life cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1510095396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2014%29&rft.atitle=Genomic+and+Epigenomic+Changes+in+the+Liver+and+Kidney+During+the+Rat+Life+Cycle&rft.au=Fuscoe%2C+James&rft.aulast=Fuscoe&rft.aufirst=James&rft.date=2014-02-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2014%29&rft.issn=&rft_id=info:doi/ L2 - https://aaas.confex.com/aaas/2014/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-24 N1 - Last updated - 2014-03-26 ER - TY - CPAPER T1 - The US Approaches to Detect and Mount a Rapid Research Response to Emerging Infectious Diseases with Pandemic Potential T2 - 2014 Annual Meeting of the American Association for the Advancement of Science (AAAS 2014) AN - 1510095289; 6279839 JF - 2014 Annual Meeting of the American Association for the Advancement of Science (AAAS 2014) AU - Lurie, Nicole Y1 - 2014/02/13/ PY - 2014 DA - 2014 Feb 13 KW - Disease detection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1510095289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2014+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2014%29&rft.atitle=The+US+Approaches+to+Detect+and+Mount+a+Rapid+Research+Response+to+Emerging+Infectious+Diseases+with+Pandemic+Potential&rft.au=Lurie%2C+Nicole&rft.aulast=Lurie&rft.aufirst=Nicole&rft.date=2014-02-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2014+Annual+Meeting+of+the+American+Association+for+the+Advancement+of+Science+%28AAAS+2014%29&rft.issn=&rft_id=info:doi/ L2 - https://aaas.confex.com/aaas/2014/webprogram/start.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-24 N1 - Last updated - 2014-03-26 ER - TY - JOUR T1 - Subchronic oral toxicity of evodia fruit powder in rats. AN - 1494305879; 24384379 AB - Evodia, a fruit from Evodia rutaecarpa, has been used in oriental medicine, and since its various pharmaceutical actions, including anti-cancer activity, have become known, evodia has been widely used as a dietary supplement. However, information regarding its toxicity is limited. Evodia fruit from Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang (0, 25, 74, 222, 667, and 2000 mg/kg) was administered orally five times per week for 13 weeks. Clinical signs, body weight, food consumption, hematology, serum chemistry, urinalysis, vaginal cytology, sperm morphology, organ weight, and gross and histopathological findings were evaluated. Urinary ketone body excretion was detected in males at 667 and 2000 mg/kg and in females at 2000 mg/kg. An increase in absolute/relative liver weight was observed in both sexes at 2000 mg/kg. Although levels of serum alanine aminotransferase, glucose, total cholesterol, and triglycerides were significantly reduced in males and/or females at 200 and/or 667 and 2000 mg/kg, all values were within normal ranges and were considered non-adverse. In addition, no treatment-related differences in body weight, food consumption, hematology, vaginal cytology, sperm morphology, or gross and histopathological examination were detected. The subchronic no-observable-adverse-effect level for evodia fruit powder following oral administration in rats is greater than 2000 mg/kg. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. JF - Journal of ethnopharmacology AU - Kim, Duyeol AU - Lee, Yong-Hoon AU - Park, Sun Hee AU - Lee, Mi Ju AU - Kim, Myoung Jun AU - Jang, Ho-Song AU - Lee, Jung-Min AU - Lee, Hye-Yeong AU - Han, Beom Seok AU - Son, Woo-Chan AU - Seok, Ji Hyeon AU - Lee, Jong Kwon AU - Jeong, Jayoung AU - Kang, Jin Seok AU - Kang, Jong-Koo AD - Department of Pathology, Biotoxtech Co., Ltd., 686-2 Yangcheong-ri, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea. ; Department of Pathology, Biotoxtech Co., Ltd., 686-2 Yangcheong-ri, Ochang-eup, Cheongwon-gun, Chungbuk 363-883, Republic of Korea; Department of Biomedical Laboratory Science, Namseoul University, 21 Maeju-ri, Seonghwan-eup, Cheonan, Chungnam 331-707, Republic of Korea. ; Hoseo Toxicity Research Center, Hoseo University Biomedical Laboratory Science, 79 Hoseo-ro BaeBang-Myeon, Asan, Chungnam 336-795, Republic of Korea. ; Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 88 Olympic-ro-43-gil, Songpa-gu, Seoul 138-736, Republic of Korea. ; Toxicological Research Divison, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Osong Health Technology Administration Complex, 187 Osongsaengmyeong2-ro, Osong, Cheongwon, Chungbuk 363-700, Republic of Korea. ; Department of Biomedical Laboratory Science, Namseoul University, 21 Maeju-ri, Seonghwan-eup, Cheonan, Chungnam 331-707, Republic of Korea. Electronic address: kang@nsu.ac.kr. ; Department of Laboratory Animal medicine, College of Veterinary medicine, Chungbuk National University, 410 Naesudong-ro, Heungdeok-gu, Cheongju, Chungbuk 361-763, Republic of Korea. Electronic address: jkkang@cbu.ac.kr. Y1 - 2014/02/12/ PY - 2014 DA - 2014 Feb 12 SP - 1072 EP - 1078 VL - 151 IS - 3 KW - Plant Preparations KW - 0 KW - Powders KW - Index Medicus KW - Rat KW - Evodia fruit KW - Subchronic toxicity KW - Rats KW - Animals KW - Rats, Inbred F344 KW - No-Observed-Adverse-Effect Level KW - Toxicity Tests, Subchronic KW - Fruit KW - Male KW - Female KW - Plant Preparations -- toxicity KW - Evodia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1494305879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+ethnopharmacology&rft.atitle=Subchronic+oral+toxicity+of+evodia+fruit+powder+in+rats.&rft.au=Kim%2C+Duyeol%3BLee%2C+Yong-Hoon%3BPark%2C+Sun+Hee%3BLee%2C+Mi+Ju%3BKim%2C+Myoung+Jun%3BJang%2C+Ho-Song%3BLee%2C+Jung-Min%3BLee%2C+Hye-Yeong%3BHan%2C+Beom+Seok%3BSon%2C+Woo-Chan%3BSeok%2C+Ji+Hyeon%3BLee%2C+Jong+Kwon%3BJeong%2C+Jayoung%3BKang%2C+Jin+Seok%3BKang%2C+Jong-Koo&rft.aulast=Kim&rft.aufirst=Duyeol&rft.date=2014-02-12&rft.volume=151&rft.issue=3&rft.spage=1072&rft.isbn=&rft.btitle=&rft.title=Journal+of+ethnopharmacology&rft.issn=1872-7573&rft_id=info:doi/10.1016%2Fj.jep.2013.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-26 N1 - Date created - 2014-02-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jep.2013.12.006 ER - TY - JOUR T1 - RNAi-based inhibition of porcine reproductive and respiratory syndrome virus replication in transgenic pigs. AN - 1494306740; 24333125 AB - Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating viral disease causing heavy losses to the swine industry worldwide. Many studies have shown that transient delivery of small interfering RNA (siRNA) or adenovirus-mediated RNA interfere (RNAi) could potentially inhibit porcine reproductive and respiratory syndrome virus (PRRSV) replication in vivo and in vitro. Here, we applied RNAi to produce transgenic (TG) pigs that constitutively expressed PRRSV-specific siRNA derived from small hairpin RNA (shRNA). First, we evaluated siRNA expression in the founding and F1 generation pigs and confirmed stable transmission. Then, we detected the expression of IFN-β and protein kinase R (PKR) and found no difference among TG, non-transgenic (NTG), and wild-type pigs. Lastly, the F1 generation pigs, including TG and NTG piglets, were challenged with 3×10⁴·⁵ TCID₅₀ of JXA1, a highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV). Our results showed that the in vivo siRNA expression substantially reduced the serum HP-PRRSV titers and increased survival time by 3 days when TG pigs were compared with the NTG controls. These data suggested that RNAi-based genetic modification might be used to breed viral-resistant livestock with stable siRNA expression with no complications of siRNA toxicity. Copyright © 2013. Published by Elsevier B.V. JF - Journal of biotechnology AU - Li, Li AU - Li, Qiuyan AU - Bao, Yonghua AU - Li, Jinxiu AU - Chen, Zhisheng AU - Yu, Xiuling AU - Zhao, Yaofeng AU - Tian, Kegong AU - Li, Ning AD - State Key Laboratories of Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing 100193, China; Department of Molecular Biology, College of Biological Science, China Agricultural University, Beijing 100193, China. ; OIE Porcine Reproductive and Respiratory Syndrome Reference Laboratory, China Animal Disease Control Center, No. 20 Maizidian Road, Chaoyang District, Beijing 100125, China. ; OIE Porcine Reproductive and Respiratory Syndrome Reference Laboratory, China Animal Disease Control Center, No. 20 Maizidian Road, Chaoyang District, Beijing 100125, China; National Research Center for Veterinary Medicine, Cuiwei Road, High-Tech. District, Luoyang, Henan Provice, China. ; State Key Laboratories of Agrobiotechnology, College of Biological Science, China Agricultural University, Beijing 100193, China; Department of Molecular Biology, College of Biological Science, China Agricultural University, Beijing 100193, China. Electronic address: ninglcau@cau.edu.cn. Y1 - 2014/02/10/ PY - 2014 DA - 2014 Feb 10 SP - 17 EP - 24 VL - 171 KW - RNA, Small Interfering KW - 0 KW - Index Medicus KW - Transgenic pig KW - Porcine reproductive and respiratory syndrome virus (PRRSV) KW - Somatic cell nuclear transplantation (SCNT) KW - RNA interference KW - Macrophages, Alveolar KW - Nuclear Transfer Techniques KW - Animals KW - Cells, Cultured KW - Porcine Reproductive and Respiratory Syndrome -- genetics KW - Porcine Reproductive and Respiratory Syndrome -- prevention & control KW - Male KW - Female KW - Swine -- genetics KW - Survival Analysis KW - Porcine respiratory and reproductive syndrome virus -- genetics KW - Animals, Genetically Modified -- genetics KW - RNA, Small Interfering -- genetics KW - RNA Interference UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1494306740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biotechnology&rft.atitle=RNAi-based+inhibition+of+porcine+reproductive+and+respiratory+syndrome+virus+replication+in+transgenic+pigs.&rft.au=Li%2C+Li%3BLi%2C+Qiuyan%3BBao%2C+Yonghua%3BLi%2C+Jinxiu%3BChen%2C+Zhisheng%3BYu%2C+Xiuling%3BZhao%2C+Yaofeng%3BTian%2C+Kegong%3BLi%2C+Ning&rft.aulast=Li&rft.aufirst=Li&rft.date=2014-02-10&rft.volume=171&rft.issue=&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+biotechnology&rft.issn=1873-4863&rft_id=info:doi/10.1016%2Fj.jbiotec.2013.11.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-08 N1 - Date created - 2014-02-03 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.jbiotec.2013.11.022 ER - TY - JOUR T1 - MSC-based product characterization for clinical trials: an FDA perspective. AN - 1499144246; 24506881 AB - Proposals submitted to the FDA for MSC-based products are undergoing a rapid expansion that is characterized by increased variability in donor and tissue sources, manufacturing processes, proposed functional mechanisms, and characterization methods. Here we discuss the diversity in MSC-based clinical trial product proposals and highlight potential challenges for clinical translation. Copyright © 2014 Elsevier Inc. All rights reserved. JF - Cell stem cell AU - Mendicino, Michael AU - Bailey, Alexander M AU - Wonnacott, Keith AU - Puri, Raj K AU - Bauer, Steven R AD - Office of the Commissioner (OC), Office of the Chief Scientist (OCS), Office of Regulatory Science and Innovation (ORSI), 10903 New Hampshire Boulevard, Silver Spring, MD 20993, USA; Center for Biologics Evaluation and Research (CBER), Office of Cellular, Tissue and Gene Therapy (OCTGT), Division of Cell and Gene Therapy (DCGT), 1401 Rockville Pike, Rockville, MD 20852, USA. Electronic address: m.mendicino.phd@gmail.com. ; CBER, OCTGT, Division of Clinical Evaluation and Pharmacology/Toxicology (DCEPT), 1401 Rockville Pike, Rockville, MD 20852, USA. ; Center for Biologics Evaluation and Research (CBER), Office of Cellular, Tissue and Gene Therapy (OCTGT), Division of Cell and Gene Therapy (DCGT), 1401 Rockville Pike, Rockville, MD 20852, USA. ; Center for Biologics Evaluation and Research (CBER), Office of Cellular, Tissue and Gene Therapy (OCTGT), Division of Cell and Gene Therapy (DCGT), 1401 Rockville Pike, Rockville, MD 20852, USA. Electronic address: steven.bauer@fda.hhs.gov. Y1 - 2014/02/06/ PY - 2014 DA - 2014 Feb 06 SP - 141 EP - 145 VL - 14 IS - 2 KW - Biomarkers KW - 0 KW - Index Medicus KW - United States KW - Humans KW - Biomarkers -- metabolism KW - Cell Membrane -- metabolism KW - Tissue Donors KW - United States Food and Drug Administration -- legislation & jurisprudence KW - Stem Cell Research -- legislation & jurisprudence KW - Mesenchymal Stromal Cells -- cytology KW - Clinical Trials as Topic -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499144246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+stem+cell&rft.atitle=MSC-based+product+characterization+for+clinical+trials%3A+an+FDA+perspective.&rft.au=Mendicino%2C+Michael%3BBailey%2C+Alexander+M%3BWonnacott%2C+Keith%3BPuri%2C+Raj+K%3BBauer%2C+Steven+R&rft.aulast=Mendicino&rft.aufirst=Michael&rft.date=2014-02-06&rft.volume=14&rft.issue=2&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Cell+stem+cell&rft.issn=1875-9777&rft_id=info:doi/10.1016%2Fj.stem.2014.01.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-01-14 N1 - Date created - 2014-02-10 N1 - Date revised - 2017-01-14 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.stem.2014.01.013 ER - TY - JOUR T1 - Intussusception risk after rotavirus vaccination in U.S. infants. AN - 1499129210; 24422676 AB - International postlicensure studies have identified an increased risk of intussusception after vaccination with the second-generation rotavirus vaccines RotaTeq (RV5, a pentavalent vaccine) and Rotarix (RV1, a monovalent vaccine). We studied this association among infants in the United States. The study included data from infants 5.0 to 36.9 weeks of age who were enrolled in three U.S. health plans that participate in the Mini-Sentinel program sponsored by the Food and Drug Administration. Potential cases of intussusception and vaccine exposures from 2004 through mid-2011 were identified through procedural and diagnostic codes. Medical records were reviewed to confirm the occurrence of intussusception and the status with respect to rotavirus vaccination. The primary analysis used a self-controlled risk-interval design that included only vaccinated children. The secondary analysis used a cohort design that included exposed and unexposed person-time. The analyses included 507,874 first doses and 1,277,556 total doses of RV5 and 53,638 first doses and 103,098 total doses of RV1. The statistical power for the analysis of RV1 was lower than that for the analysis of RV5. The number of excess cases of intussusception per 100,000 recipients of the first dose of RV5 was significantly elevated, both in the primary analysis (attributable risk, 1.1 [95% confidence interval, 0.3 to 2.7] for the 7-day risk window and 1.5 [95% CI, 0.2 to 3.2] for the 21-day risk window) and in the secondary analysis (attributable risk, 1.2 [95% CI, 0.2 to 3.2] for the 21-day risk window). No significant increase in risk was seen after dose 2 or 3. The results with respect to the primary analysis of RV1 were not significant, but the secondary analysis showed a significant risk after dose 2. RV5 was associated with approximately 1.5 (95% CI, 0.2 to 3.2) excess cases of intussusception per 100,000 recipients of the first dose. The secondary analysis of RV1 suggested a potential risk, although the study of RV1 was underpowered. These risks must be considered in light of the demonstrated benefits of rotavirus vaccination. (Funded by the Food and Drug Administration.). JF - The New England journal of medicine AU - Yih, W Katherine AU - Lieu, Tracy A AU - Kulldorff, Martin AU - Martin, David AU - McMahill-Walraven, Cheryl N AU - Platt, Richard AU - Selvam, Nandini AU - Selvan, Mano AU - Lee, Grace M AU - Nguyen, Michael AD - From the Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute (W.K.Y., T.A.L., M.K., R.P., G.M.L.), and the Division of Infectious Diseases and Department of Laboratory Medicine, Boston Children's Hospital (G.M.L.) - all in Boston; the Division of Research, Kaiser Permanente Northern California, Oakland (T.A.L.); the Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD (D.M., M.N.); Aetna, Blue Bell, PA (C.N.M.-W.); Government and Academic Research, HealthCore, Alexandria, VA (N.S.); and Comprehensive Health Insights, Humana, Louisville, KY (M.S.). Y1 - 2014/02/06/ PY - 2014 DA - 2014 Feb 06 SP - 503 EP - 512 VL - 370 IS - 6 KW - RIX4414 vaccine KW - 0 KW - RotaTeq KW - Rotavirus Vaccines KW - Vaccines, Attenuated KW - Abridged Index Medicus KW - Index Medicus KW - Infant KW - Risk KW - Vaccines, Attenuated -- administration & dosage KW - Humans KW - Cohort Studies KW - Vaccines, Attenuated -- adverse effects KW - Immunization, Secondary KW - United States -- epidemiology KW - Rotavirus Vaccines -- administration & dosage KW - Rotavirus Vaccines -- adverse effects KW - Intussusception -- etiology KW - Intussusception -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499129210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Intussusception+risk+after+rotavirus+vaccination+in+U.S.+infants.&rft.au=Yih%2C+W+Katherine%3BLieu%2C+Tracy+A%3BKulldorff%2C+Martin%3BMartin%2C+David%3BMcMahill-Walraven%2C+Cheryl+N%3BPlatt%2C+Richard%3BSelvam%2C+Nandini%3BSelvan%2C+Mano%3BLee%2C+Grace+M%3BNguyen%2C+Michael&rft.aulast=Yih&rft.aufirst=W&rft.date=2014-02-06&rft.volume=370&rft.issue=6&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/10.1056%2FNEJMoa1303164 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-02-11 N1 - Date created - 2014-02-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Comment In: N Engl J Med. 2014 May 1;370(18):1766 [24785219] N Engl J Med. 2014 Feb 6;370(6):568-70 [24422677] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1056/NEJMoa1303164 ER - TY - JOUR T1 - Recombinant antigens based on toxins A and B of Clostridium difficile that evoke a potent toxin-neutralising immune response. AN - 1492714523; 24342251 AB - Infection with the bacterium Clostridium difficile causes symptoms ranging from mild to severe diarrhoea with life-threatening complications and remains a significant burden to healthcare systems throughout the developed world. Two potent cytotoxins, TcdA and TcdB are the prime mediators of the syndrome and rapid neutralisation of these would afford significant benefits in disease management. In the present study, a broad range of non-toxic, recombinant fragments derived from TcdA and TcdB were designed for soluble expression in E. coli and assessed for their capacity to generate a potent toxin-neutralising immune response as assessed by cell-based assays. Significant differences between the efficacies of isolated TcdA and TcdB regions with respect to inducing a neutralising immune response were observed. While the C-terminal repeat regions played the principal role in generating neutralising antibodies to TcdA, in the case of TcdB, the central region domains dominated the neutralising immune response. For both TcdA and TcdB, fragments which comprised domains from both the central and C-terminal repeat region of the toxins were found to induce the most potent neutralising immune responses. Generated antibodies neutralised toxins produced by a range of C. difficile isolates including ribotype 027 and 078 strains. Passive immunisation of hamsters with a combination of antibodies to TcdA and TcdB fragments afforded complete protection from severe CDI induced by a challenge of bacterial spores. The results of the study are discussed with respect to the development of a cost effective immunotherapeutic approach for the management of C. difficile infection. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved. JF - Vaccine AU - Maynard-Smith, Michael AU - Ahern, Helen AU - McGlashan, Joanna AU - Nugent, Philip AU - Ling, Roger AU - Denton, Harriet AU - Coxon, Ruth AU - Landon, John AU - Roberts, April AU - Shone, Clifford AD - Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. ; MicroPharm Ltd, Station Road Industrial Estate, Newcastle Emlyn, Carmarthenshire SA38 9BY, UK. ; Public Health England, Porton Down, Salisbury, Wiltshire SP4 0JG, UK. Electronic address: cliff.shone@phe.gov.uk. Y1 - 2014/02/03/ PY - 2014 DA - 2014 Feb 03 SP - 700 EP - 705 VL - 32 IS - 6 KW - Antibodies, Bacterial KW - 0 KW - Antibodies, Neutralizing KW - Antigens, Bacterial KW - Bacterial Proteins KW - Bacterial Toxins KW - Enterotoxins KW - Immune Sera KW - Recombinant Proteins KW - tcdA protein, Clostridium difficile KW - toxB protein, Clostridium difficile KW - Index Medicus KW - Immunotherapy KW - Vaccine KW - Difficile KW - Recombinant KW - Infection KW - Toxins KW - Animals KW - Escherichia coli -- metabolism KW - Sheep KW - Immunization, Passive KW - Cercopithecus aethiops KW - Recombinant Proteins -- immunology KW - Immune Sera -- immunology KW - Vero Cells KW - Antibodies, Neutralizing -- immunology KW - Cricetinae KW - Enterotoxins -- immunology KW - Bacterial Proteins -- immunology KW - Antibodies, Bacterial -- immunology KW - Clostridium difficile KW - Antigens, Bacterial -- immunology KW - Bacterial Toxins -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492714523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Recombinant+antigens+based+on+toxins+A+and+B+of+Clostridium+difficile+that+evoke+a+potent+toxin-neutralising+immune+response.&rft.au=Maynard-Smith%2C+Michael%3BAhern%2C+Helen%3BMcGlashan%2C+Joanna%3BNugent%2C+Philip%3BLing%2C+Roger%3BDenton%2C+Harriet%3BCoxon%2C+Ruth%3BLandon%2C+John%3BRoberts%2C+April%3BShone%2C+Clifford&rft.aulast=Maynard-Smith&rft.aufirst=Michael&rft.date=2014-02-03&rft.volume=32&rft.issue=6&rft.spage=700&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=1873-2518&rft_id=info:doi/10.1016%2Fj.vaccine.2013.11.099 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-08-13 N1 - Date created - 2014-01-29 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Toxicon. 2001 Feb-Mar;39(2-3):325-33 [10978751] Am J Surg. 2012 Dec;204(6):836-42 [23036604] J Infect Dis. 2001 Jun 15;183(12):1760-6 [11372028] J Biol Chem. 2004 Feb 20;279(8):6235-43 [14638685] Vaccine. 2004 Feb 17;22(7):848-56 [15040937] J Clin Pathol. 1986 Jun;39(6):672-6 [3722420] Infect Immun. 1991 Jun;59(6):2215-8 [2037383] Gastroenterologist. 1994 Mar;2(1):61-9 [8055233] Mol Microbiol. 1995 Jul;17(2):313-21 [7494480] Gene. 1996 Nov 28;181(1-2):29-38 [8973304] Infect Immun. 1998 May;66(5):2018-25 [9573084] J Antimicrob Chemother. 1998 May;41 Suppl C:13-9 [9630370] J Clin Microbiol. 1998 Aug;36(8):2240-7 [9665999] Infect Immun. 1999 Feb;67(2):527-38 [9916055] Infect Immun. 1999 May;67(5):2145-52 [10225867] Infect Immun. 1999 Oct;67(10):5124-32 [10496886] J Med Microbiol. 2005 Feb;54(Pt 2):197-205 [15673517] Infect Immun. 2006 Nov;74(11):6339-47 [16966409] Ann Intern Med. 2006 Nov 21;145(10):758-64 [17116920] J Biol Chem. 2007 Aug 31;282(35):25314-21 [17591770] FEMS Microbiol Rev. 2008 May;32(3):541-55 [18397287] Trends Microbiol. 2008 May;16(5):222-9 [18394902] Br J Biomed Sci. 2008;65(1):39-44 [18476496] Vaccine. 2009 Jun 2;27(27):3598-604 [19464540] Infect Immun. 2009 Jul;77(7):2795-801 [19398544] J Biol Chem. 2009 Dec 11;284(50):34666-73 [19808679] N Engl J Med. 2010 Jan 21;362(3):197-205 [20089970] Clin Infect Dis. 2010 Dec 1;51(11):1306-13 [20979491] Lancet. 2011 Jan 1;377(9759):63-73 [21084111] Infect Immun. 2011 Jun;79(6):2295-302 [21482682] Nat Rev Gastroenterol Hepatol. 2011 Jun;8(6):330-9 [21502971] Infect Immun. 2012 Feb;80(2):875-82 [22144483] Vaccine. 2012 Feb 14;30(8):1492-501 [22200503] Vaccine. 2012 Mar 16;30(13):2245-9 [22306375] Vaccine. 2012 Jun 13;30(28):4249-58 [22537987] Clin Infect Dis. 2012 Aug;55 Suppl 2:S88-92 [22752870] Infect Immun. 2012 Aug;80(8):2678-88 [22615245] Microbiology. 2001 Feb;147(Pt 2):439-47 [11158361] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.vaccine.2013.11.099 ER - TY - GEN T1 - Early Childhood Developmental Screening: A Compendium of Measures for Children Ages Birth to Five. OPRE Report 2014-11 AN - 1773218430; ED561406 AB - For children age birth to five, physical, cognitive, linguistic, and social-emotional growth and development occur at a rapid pace. While all children in this age range may not reach developmental milestones (e.g., smiling, saying first words, taking first steps) at the same time, development that does not happen within an expected timeframe can raise concerns about developmental disorders, health conditions, or other factors that may negatively impact the child's development. Early, frequent screening of young children for healthy growth and development is recommended to help identify potential problems or areas needing further evaluation. For developmental screening to be effective, it should begin early in a child's life-be repeated throughout early childhood; and use reliable, valid screening tools appropriate to the age, culture, and language of the child. This compendium has been created to help practitioners better understand this information and make informed choices about the developmental screening tools they use with children birth to age five. It aims to: (1) discuss the purpose of developmental screening and how it differs from child assessment; (2) "translate" technical psychometric information about the reliability and validity of commonly-used developmental screening tools into language that is easily understood by early childhood practitioners; and (3) highlight areas in which the early childhood field is lacking information on reliability and validity of available developmental screening tools. (Individual sections contain references.) Two appendices are included: (1) Glossary of Terms; and (2) Psychometric Documentation and Rationale. AU - Moodie, Shannon AU - Daneri, Paula AU - Goldhagen, Samantha AU - Halle, Tamara AU - Green, Katie AU - LaMonte, Lauren Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 160 PB - US Department of Health and Human Services. 200 Independence Avenue SW, Washington, DC 20201. KW - Battelle Developmental Inventory KW - Bayley Scales of Infant Development KW - Brigance K and 1 Screen KW - Denver Developmental Screening Test KW - Developmental Indicators Assessment Learning KW - Early Screening Profiles KW - Learning Accomplishment Profile KW - ERIC, Resources in Education (RIE) KW - Practitioners KW - Questionnaires KW - Young Children KW - Well Being KW - Individual Characteristics KW - Test Validity KW - Psychometrics KW - Measurement Techniques KW - Screening Tests KW - Evaluation Methods KW - Test Reliability KW - Developmental Stages KW - Child Development KW - Parents KW - Preschool Children KW - Infants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773218430?accountid=14244 LA - English DB - ERIC N1 - Last updated - 2017-01-13 ER - TY - JOUR T1 - Detection of Live Escherichia coli O157:H7 Cells by PMA-qPCR AN - 1560120486; 20496994 AB - A unique open reading frame (ORF) Z3276 was identified as a specific genetic marker for E. coli O157:H7. A qPCR assay was developed for detection of E. coli O157:H7 by targeting ORF Z3276. With this assay, we can detect as low as a few copies of the genome of DNA of E. coli O157:H7. The sensitivity and specificity of the assay were confirmed by intensive validation tests with a large number of E. coli O157:H7 strains (n = 369) and non-O157 strains (n = 112). Furthermore, we have combined propidium monoazide (PMA) procedure with the newly developed qPCR protocol for selective detection of live cells from dead cells. Amplification of DNA from PMA-treated dead cells was almost completely inhibited in contrast to virtually unaffected amplification of DNA from PMA-treated live cells. Additionally, the protocol has been modified and adapted to a 96-well plate format for an easy and consistent handling of a large number of samples. This method is expected to have an impact on accurate microbiological and epidemiological monitoring of food safety and environmental source. JF - Journal of Visualized Experiments AU - Li, Baoguang AU - Hu, Zonglin AU - Elkins, Christopher A AD - Center for Food Safety and Applied Nutrition, Division of Molecular Biology, Food and Drug Administration Y1 - 2014/02/01/ PY - 2014 DA - 2014 Feb 01 PB - Journal of Visualized Experiments, 48 Grove St. Somerville, MA 02144 United States IS - 84 KW - Microbiology Abstracts B: Bacteriology KW - Microbiology KW - Issue 84 KW - Propidium monoazide (PMA) KW - real-time PCR KW - E. coli O157:H7 KW - pathogen KW - selective detection KW - live cells KW - Genomes KW - Phorbol esters KW - Food KW - Genetic markers KW - Escherichia coli KW - DNA KW - Open reading frames KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560120486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Visualized+Experiments&rft.atitle=Detection+of+Live+Escherichia+coli+O157%3AH7+Cells+by+PMA-qPCR&rft.au=Li%2C+Baoguang%3BHu%2C+Zonglin%3BElkins%2C+Christopher+A&rft.aulast=Li&rft.aufirst=Baoguang&rft.date=2014-02-01&rft.volume=&rft.issue=84&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Journal+of+Visualized+Experiments&rft.issn=1940-087X&rft_id=info:doi/10.3791%2F50967 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Genomes; Phorbol esters; Food; Genetic markers; DNA; Open reading frames; Escherichia coli DO - http://dx.doi.org/10.3791/50967 ER - TY - JOUR T1 - Which individuals make dropout informative? AN - 1541982364; 201417492 AB - Markers are internal host factors that measure the current disease or recovery status of an individual. Individuals with more advanced disease progression are more likely to drop out, e.g. because they die. Marker data after dropout are missing. Such missingness is certainly not completely at random. A mixed effects model can be used if missingness of the marker data depends on measured marker values only (missing at random). If missingness is not at random, such models yield biased results. We describe various approaches that jointly model the marker development and dropout risk and may eliminate bias. One example of such a model is a random effects selection model. Based on a real data set with frequent follow-up, we compare results from a random effects model and a random effects selection model. Results are remarkably similar. In a simulation study, we investigate how the bias in the parameter estimates from a random effects model depends on the frequency of measurements and the time between the last measurement and the dropout or censoring time. Results from the simulation study confirm that the bias is small if follow-up is frequent. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Geskus, Ronald B AD - Academic Medical Center, Amsterdam, The Netherlands Public Health Service Amsterdam, Amsterdam, The Netherlands statistics@inter.nl.net Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 91 EP - 106 PB - Sage Publications, London UK VL - 23 IS - 1 SN - 0962-2802, 0962-2802 KW - Longitudinal data missing not at random random effects selection model AIDS markers KW - Parameters KW - Measurement KW - Random effects KW - Dropping out KW - Simulation KW - Bias KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1541982364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Which+individuals+make+dropout+informative%3F&rft.au=Geskus%2C+Ronald+B&rft.aulast=Geskus&rft.aufirst=Ronald&rft.date=2014-02-01&rft.volume=23&rft.issue=1&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280212445840 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-07-01 N1 - Number of references - 46 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Random effects; Dropping out; Bias; Simulation; Measurement; Parameters DO - http://dx.doi.org/10.1177/0962280212445840 ER - TY - JOUR T1 - Workshop report: The 2012 Antimicrobial Agents in Veterinary Medicine: exploring the consequences of antimicrobial drug use: a 3-D approach AN - 1524417978; 19018602 AB - Antimicrobial resistance is a global challenge that impacts both human and veterinary health care. The resilience of microbes is reflected in their ability to adapt and survive in spite of our best efforts to constrain their infectious capabilities. As science advances, many of the mechanisms for microbial survival and resistance element transfer have been identified. During the 2012 meeting of Antimicrobial Agents in Veterinary Medicine (AAVM), experts provided insights on such issues as use vs. resistance, the available tools for supporting appropriate drug use, the importance of meeting the therapeutic needs within the domestic animal health care, and the requirements associated with food safety and food security. This report aims to provide a summary of the presentations and discussions occurring during the 2012 AAVM with the goal of stimulating future discussions and enhancing the opportunity to establish creative and sustainable solutions that will guarantee the availability of an effective therapeutic arsenal for veterinary species. JF - Journal of Veterinary Pharmacology and Therapeutics AU - Martinez, M AU - Blondeau, J AU - Cerniglia, CE AU - Fink-Gremmels, J AU - Guenther, S AU - Hunter, R P AU - Li, X-Z AU - Papich, M AU - Silley, P AU - Soback, S AU - Toutain, P-L AU - Zhang, Q AD - Food and Drug Administration. Center for Veterinary Medicine Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - e1 EP - e16 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 37 IS - 1 SN - 0140-7783, 0140-7783 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Domestic animals KW - Veterinary medicine KW - Conferences KW - Food KW - Drug resistance KW - Survival KW - Antimicrobial agents KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524417978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.atitle=Workshop+report%3A+The+2012+Antimicrobial+Agents+in+Veterinary+Medicine%3A+exploring+the+consequences+of+antimicrobial+drug+use%3A+a+3-D+approach&rft.au=Martinez%2C+M%3BBlondeau%2C+J%3BCerniglia%2C+CE%3BFink-Gremmels%2C+J%3BGuenther%2C+S%3BHunter%2C+R+P%3BLi%2C+X-Z%3BPapich%2C+M%3BSilley%2C+P%3BSoback%2C+S%3BToutain%2C+P-L%3BZhang%2C+Q&rft.aulast=Martinez&rft.aufirst=M&rft.date=2014-02-01&rft.volume=37&rft.issue=1&rft.spage=e1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Veterinary+Pharmacology+and+Therapeutics&rft.issn=01407783&rft_id=info:doi/10.1111%2Fjvp.12104 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2014-09-05 N1 - SubjectsTermNotLitGenreText - Domestic animals; Veterinary medicine; Conferences; Drug resistance; Food; Survival; Antimicrobial agents DO - http://dx.doi.org/10.1111/jvp.12104 ER - TY - JOUR T1 - Transfusion-associated circulatory overload (TACO) and potential risk factors among the inpatient US elderly as recorded in Medicare administrative databases during 2011 AN - 1505329741; 19037065 AB - Transfusion-associated circulatory overload (TACO) is a serious transfusion complication resulting in respiratory distress. The study's objective was to assess TACO occurrence and potential risk factors among elderly Medicare beneficiaries (ages 65 and older) in the inpatient setting during 2011. This retrospective claims-based study utilized Medicare administrative databases in coordination with Centers for Medicare & Medicaid Services. Transfusions were identified by recorded procedure and revenue centre codes, while TACO was ascertained via ICD-9-CM diagnosis code. We evaluated TACO diagnosis code rates overall and by age, gender, race, number of units and blood components transfused. Multivariate logistic regression analyses were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Among 2 147 038 inpatient transfusion stays for elderly in 2011, 1340 had TACO diagnosis code, overall rate of 62.4 per 100 000 stays. TACO rates increased significantly with age and units transfused (P < 0.0001). After adjustment for confounding, significantly higher odds of TACO were found for women vs. men (OR = 1.40, 95% CI 1.26-1.60), White people vs. non-White people (OR = 1.38, 95% CI 1.20-1.62) and persons with congestive heart failure (OR = 1.61, 95% CI 1.44-1.88), chronic pulmonary disease (OR = 1.19, 95% CI 1.08-1.32) and different anaemias. Our study identified largest number of potential TACO cases to date and showed a substantial increase in TACO occurrence with age and number of units transfused. The study suggested increased TACO risk in elderly with congestive heart failure, chronic pulmonary disease and anaemias. Overall, study shows importance of large administrative databases as an additional epidemiological tool. JF - Vox Sanguinis AU - Menis, M AU - Anderson, SA AU - Forshee, R A AU - McKean, S AU - Johnson, C AU - Holness, L AU - Warnock, R AU - Gondalia, R AU - Worrall, C M AU - Kelman, JA AU - Ball, R AU - Izurieta, H S AD - Food and Drug Administration Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 144 EP - 152 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 106 IS - 2 SN - 0042-9007, 0042-9007 KW - Risk Abstracts KW - Age KW - USA KW - Elderly KW - R2 23010:General: Models, forecasting UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1505329741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vox+Sanguinis&rft.atitle=Transfusion-associated+circulatory+overload+%28TACO%29+and+potential+risk+factors+among+the+inpatient+US+elderly+as+recorded+in+Medicare+administrative+databases+during+2011&rft.au=Menis%2C+M%3BAnderson%2C+SA%3BForshee%2C+R+A%3BMcKean%2C+S%3BJohnson%2C+C%3BHolness%2C+L%3BWarnock%2C+R%3BGondalia%2C+R%3BWorrall%2C+C+M%3BKelman%2C+JA%3BBall%2C+R%3BIzurieta%2C+H+S&rft.aulast=Menis&rft.aufirst=M&rft.date=2014-02-01&rft.volume=106&rft.issue=2&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Vox+Sanguinis&rft.issn=00429007&rft_id=info:doi/10.1111%2Fvox.12070 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-01 N1 - Last updated - 2014-03-10 N1 - SubjectsTermNotLitGenreText - Elderly; USA DO - http://dx.doi.org/10.1111/vox.12070 ER - TY - JOUR T1 - A survey of aflatoxins in sesame seeds imported into Khorasan Province, Iran AN - 1500799722; 19149635 AB - Sesame seed is one of the main nutrient substances which is used in the food industries of Khorasan Razavi, Iran. Because it is likely that stored sesame seeds are contaminated with mycotoxins, the levels of aflatoxins (AF) in five lots of imported sesame seeds before their distribution to the market were studied during one year. A total of 269 sub-samples were obtained from a total of 9,321 tons of sesame seeds from five importing companies. Aflatoxins at >1 mu g/kg were found in 50 % of all samples, but at low levels in most cases, which is illustrated by mean AFB sub(1) and total AF levels of 1.25 plus or minus 3.70 and 1.43 plus or minus 4.38 mu g/kg, respectively. A few (1.9 %) samples exceeded the National Iranian Standard maximum accepted level for AFB sub(1) (5 mu g/kg) or total AF (15 mu g/kg); the maximum total AF level found in one sample was 48 mu g/kg. The results indicate that the risk of a violative AF contamination in imported sesame seeds is not negligible but is currently relatively low. JF - Mycotoxin Research AU - Hosseininia, Ali Reza AU - Vahabzadeh, Maryam AU - Rashedinia, Marziyeh AU - Riahi-Zanjani, Bamdad AU - Karimi, Gholamreza AD - Food Control Laboratory, Food and Drug Administration, Mashhad University of Medical Sciences, Mashhad, Iran, Karimig@mums.ac.ir Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 43 EP - 46 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 30 IS - 1 SN - 0178-7888, 0178-7888 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Aflatoxins KW - Seeds KW - Sesamum KW - A 01330:Food Microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500799722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mycotoxin+Research&rft.atitle=A+survey+of+aflatoxins+in+sesame+seeds+imported+into+Khorasan+Province%2C+Iran&rft.au=Hosseininia%2C+Ali+Reza%3BVahabzadeh%2C+Maryam%3BRashedinia%2C+Marziyeh%3BRiahi-Zanjani%2C+Bamdad%3BKarimi%2C+Gholamreza&rft.aulast=Hosseininia&rft.aufirst=Ali&rft.date=2014-02-01&rft.volume=30&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Mycotoxin+Research&rft.issn=01787888&rft_id=info:doi/10.1007%2Fs12550-013-0186-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Number of references - 1 N1 - Last updated - 2014-03-20 N1 - SubjectsTermNotLitGenreText - Seeds; Sesamum DO - http://dx.doi.org/10.1007/s12550-013-0186-7 ER - TY - JOUR T1 - Lundep, a sand fly salivary endonuclease increases Leishmania parasite survival in neutrophils and inhibits XIIa contact activation in human plasma. AN - 1499136132; 24516388 AB - Neutrophils are the host's first line of defense against infections, and their extracellular traps (NET) were recently shown to kill Leishmania parasites. Here we report a NET-destroying molecule (Lundep) from the salivary glands of Lutzomyia longipalpis. Previous analysis of the sialotranscriptome of Lu. longipalpis showed the potential presence of an endonuclease. Indeed, not only was the cloned cDNA (Lundep) shown to encode a highly active ss- and dsDNAse, but also the same activity was demonstrated to be secreted by salivary glands of female Lu. longipalpis. Lundep hydrolyzes both ss- and dsDNA with little sequence specificity with a calculated DNase activity of 300000 Kunitz units per mg of protein. Disruption of PMA (phorbol 12 myristate 13 acetate)- or parasite-induced NETs by treatment with recombinant Lundep or salivary gland homogenates increases parasite survival in neutrophils. Furthermore, co-injection of recombinant Lundep with metacyclic promastigotes significantly exacerbates Leishmania infection in mice when compared with PBS alone or inactive (mutagenized) Lundep. We hypothesize that Lundep helps the parasite to establish an infection by allowing it to escape from the leishmanicidal activity of NETs early after inoculation. Lundep may also assist blood meal intake by lowering the local viscosity caused by the release of host DNA and as an anticoagulant by inhibiting the intrinsic pathway of coagulation. JF - PLoS pathogens AU - Chagas, Andrezza C AU - Oliveira, Fabiano AU - Debrabant, Alain AU - Valenzuela, Jesus G AU - Ribeiro, José M C AU - Calvo, Eric AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America. ; Laboratory of Emerging Pathogens, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland, United States of America. Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 1 VL - 10 IS - 2 KW - Endonucleases KW - EC 3.1.- KW - Factor XIIa KW - EC 3.4.21.38 KW - Index Medicus KW - Animals KW - Disease Vectors KW - Salivary Glands -- immunology KW - Blood Coagulation -- physiology KW - Neutrophils -- immunology KW - Humans KW - Amino Acid Sequence KW - Mice KW - Salivary Glands -- enzymology KW - Polymerase Chain Reaction KW - Leishmania KW - Blotting, Western KW - Neutrophils -- parasitology KW - Factor XIIa -- metabolism KW - Molecular Sequence Data KW - Endonucleases -- metabolism KW - Endonucleases -- immunology KW - Leishmaniasis -- enzymology KW - Host-Parasite Interactions -- physiology KW - Psychodidae -- parasitology KW - Psychodidae -- immunology KW - Leishmaniasis -- immunology KW - Psychodidae -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499136132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+pathogens&rft.atitle=Lundep%2C+a+sand+fly+salivary+endonuclease+increases+Leishmania+parasite+survival+in+neutrophils+and+inhibits+XIIa+contact+activation+in+human+plasma.&rft.au=Chagas%2C+Andrezza+C%3BOliveira%2C+Fabiano%3BDebrabant%2C+Alain%3BValenzuela%2C+Jesus+G%3BRibeiro%2C+Jos%C3%A9+M+C%3BCalvo%2C+Eric&rft.aulast=Chagas&rft.aufirst=Andrezza&rft.date=2014-02-01&rft.volume=10&rft.issue=2&rft.spage=e1003923&rft.isbn=&rft.btitle=&rft.title=PLoS+pathogens&rft.issn=1553-7374&rft_id=info:doi/10.1371%2Fjournal.ppat.1003923 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-10-03 N1 - Date created - 2014-02-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Infect Immun. 2011 Mar;79(3):1124-33 [21189319] J Immunol. 2010 Oct 1;185(7):4319-27 [20826753] J Leukoc Biol. 2011 Sep;90(3):575-82 [21685247] PLoS Negl Trop Dis. 2011 Aug;5(8):e1288 [21886852] PLoS One. 2012;7(5):e35671 [22693548] Front Cell Infect Microbiol. 2012;2:59 [22919650] Thromb Res. 2012 Oct;130 Suppl 1:S78-83 [23026673] J Invest Dermatol. 2012 Dec;132(12):2735-43 [22739793] Hamostaseologie. 2013;33(1):37-42 [23328880] Acta Crystallogr D Biol Crystallogr. 2000 May;56(Pt 5):567-72 [10771425] J Biol Chem. 2000 May 26;275(21):16366-72 [10748102] Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6704-9 [10841567] Science. 2000 Nov 17;290(5495):1351-4 [11082061] J Immunol. 2001 Nov 1;167(9):5226-30 [11673536] Infect Immun. 2002 Feb;70(2):826-35 [11796617] J Exp Biol. 2004 Oct;207(Pt 21):3717-29 [15371479] Science. 1988 Mar 11;239(4845):1306-8 [3344436] Comput Appl Biosci. 1994 Apr;10(2):189-91 [8019868] Trends Biochem Sci. 1998 Oct;23(10):403-5 [9810230] J Mol Biol. 1999 May 21;288(5):975-87 [10329193] Curr Biol. 2006 Feb 21;16(4):396-400 [16488874] Curr Biol. 2006 Feb 21;16(4):401-7 [16488875] J Exp Biol. 2006 Jul;209(Pt 14):2651-9 [16809456] Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10125-30 [18626016] Science. 2008 Aug 15;321(5891):970-4 [18703742] PLoS Negl Trop Dis. 2008;2(9):e294 [18820742] Parasitol Int. 2009 Mar;58(1):1-5 [18768167] Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3728-33 [19234127] Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6748-53 [19346483] J Biomed Biotechnol. 2010;2010:719361 [19884987] J Innate Immun. 2009;1(3):225-30 [20375580] J Innate Immun. 2009;1(6):527-42 [20375609] Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15880-5 [20798043] Cell Mol Life Sci. 2011 Jun;68(11):1863-70 [21369708] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.ppat.1003923 ER - TY - JOUR T1 - Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide. AN - 1499136113; 24516685 AB - Protective immunity against cholera is serogroup specific. Serogroup specificity in Vibrio cholerae is determined by the O-specific polysaccharide (OSP) of lipopolysaccharide (LPS). Generally, polysaccharides are poorly immunogenic, especially in young children. Here we report the evaluation in mice of a conjugate vaccine for cholera (OSP:TThc) made from V. cholerae O1 Ogawa O-Specific Polysaccharide-core (OSP) and recombinant tetanus toxoid heavy chain fragment (TThc). We immunized mice intramuscularly on days 0, 21, and 42 with OSP:TThc or OSP only, with or without dmLT, a non-toxigenic immunoadjuvant derived from heat labile toxin of Escherichia coli. We detected significant serum IgG antibody responses targeting OSP following a single immunization in mice receiving OSP:TThc with or without adjuvant. Anti-LPS IgG responses were detected following a second immunization in these cohorts. No anti-OSP or anti-LPS IgG responses were detected at any time in animals receiving un-conjugated OSP with or without immunoadjuvant, and in animals receiving immunoadjuvant alone. Responses were highest following immunization with adjuvant. Serum anti-OSP IgM responses were detected in mice receiving OSP:TThc with or without immunoadjuvant, and in mice receiving unconjugated OSP. Serum anti-LPS IgM and vibriocidal responses were detected in all vaccine cohorts except in mice receiving immunoadjuvant alone. No significant IgA anti-OSP or anti-LPS responses developed in any group. Administration of OSP:TThc and adjuvant also induced memory B cell responses targeting OSP and resulted in 95% protective efficacy in a mouse lethality cholera challenge model. We describe a protectively immunogenic cholera conjugate in mice. Development of a cholera conjugate vaccine could assist in inducing long-term protective immunity, especially in young children who respond poorly to polysaccharide antigens. JF - PLoS neglected tropical diseases AU - Alam, Mohammad Murshid AU - Bufano, Megan Kelly AU - Xu, Peng AU - Kalsy, Anuj AU - Yu, Y AU - Freeman, Y Wu AU - Sultana, Tania AU - Rashu, Md Rasheduzzaman AU - Desai, Ishaan AU - Eckhoff, Grace AU - Leung, Daniel T AU - Charles, Richelle C AU - LaRocque, Regina C AU - Harris, Jason B AU - Clements, John D AU - Calderwood, Stephen B AU - Qadri, Firdausi AU - Vann, W F AU - Kováč, Pavol AU - Ryan, Edward T AD - Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; International Centre for Diarrheal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh. ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America. ; NIDDK, LBC, National Institutes of Health, Bethesda, Maryland, United States of America. ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; International Centre for Diarrheal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh ; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America. ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America. ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America. ; Tulane University School of Medicine, New Orleans, Louisiana, United States of America. ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America ; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, United States of America. ; International Centre for Diarrheal Disease Research, Bangladesh (ICDDR,B), Dhaka, Bangladesh. ; CBER, FDA, Laboratory of Bacterial Toxins, Bethesda, Maryland, United States of America. ; Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America ; Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America. Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 1 VL - 8 IS - 2 KW - Antibodies, Bacterial KW - 0 KW - Cholera Vaccines KW - O Antigens KW - Recombinant Proteins KW - Vaccines, Conjugate KW - Index Medicus KW - Animals KW - Recombinant Proteins -- metabolism KW - Recombinant Proteins -- immunology KW - Antibodies, Bacterial -- blood KW - Disease Models, Animal KW - Mice KW - Recombinant Proteins -- chemistry KW - Female KW - Cholera Vaccines -- chemistry KW - Cholera -- mortality KW - Vaccines, Conjugate -- immunology KW - Cholera -- immunology KW - Cholera Vaccines -- immunology KW - O Antigens -- metabolism KW - O Antigens -- immunology KW - Cholera -- prevention & control KW - Vaccines, Conjugate -- chemistry KW - O Antigens -- chemistry KW - Cholera Vaccines -- metabolism KW - Vaccines, Conjugate -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1499136113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+neglected+tropical+diseases&rft.atitle=Evaluation+in+mice+of+a+conjugate+vaccine+for+cholera+made+from+Vibrio+cholerae+O1+%28Ogawa%29+O-specific+polysaccharide.&rft.au=Alam%2C+Mohammad+Murshid%3BBufano%2C+Megan+Kelly%3BXu%2C+Peng%3BKalsy%2C+Anuj%3BYu%2C+Y%3BFreeman%2C+Y+Wu%3BSultana%2C+Tania%3BRashu%2C+Md+Rasheduzzaman%3BDesai%2C+Ishaan%3BEckhoff%2C+Grace%3BLeung%2C+Daniel+T%3BCharles%2C+Richelle+C%3BLaRocque%2C+Regina+C%3BHarris%2C+Jason+B%3BClements%2C+John+D%3BCalderwood%2C+Stephen+B%3BQadri%2C+Firdausi%3BVann%2C+W+F%3BKov%C3%A1%C4%8D%2C+Pavol%3BRyan%2C+Edward+T&rft.aulast=Alam&rft.aufirst=Mohammad&rft.date=2014-02-01&rft.volume=8&rft.issue=2&rft.spage=e2683&rft.isbn=&rft.btitle=&rft.title=PLoS+neglected+tropical+diseases&rft.issn=1935-2735&rft_id=info:doi/10.1371%2Fjournal.pntd.0002683 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-11-03 N1 - Date created - 2014-02-11 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Infect Immun. 2000 Feb;68(2):977-81 [10639476] Vaccine. 2009 Aug 6;27(36):4917-22 [19563890] Lancet. 2009 Nov 14;374(9702):1694-702 [19819004] Glycoconj J. 2010 Jan;27(1):69-77 [19757026] Vaccine. 2010 Feb 3;28(5):1404-11 [19897067] Cochrane Database Syst Rev. 2010;(8):CD000974 [20687062] Cochrane Database Syst Rev. 2011;(3):CD008603 [21412922] Clin Vaccine Immunol. 2011 Apr;18(4):546-51 [21288994] Clin Vaccine Immunol. 2011 May;18(5):844-50 [21346055] Clin Vaccine Immunol. 2011 Aug;18(8):1317-25 [21697337] J Infect Dis. 2011 Sep 15;204(6):912-8 [21849288] Wkly Epidemiol Rec. 2012 Aug 3;87(31/32):289–304 [22905370] Clin Vaccine Immunol. 2012 Nov;19(11):1712-21 [22993410] PLoS One. 2012;7(12):e51718 [23284753] Pathog Dis. 2013 Mar;67(2):136-58 [23620159] Clin Vaccine Immunol. 2013 Jun;20(6):780-8 [23515016] J Mass Spectrom. 2013 Oct;48(10):1083-90 [24130011] Glycoconj J. 2013 Dec;30(9):857-70 [23949787] Glycoconj J. 2013 Dec;30(9):871-80 [23955520] Pathog Dis. 2014 Mar;70(2):153-7 [23966359] Bioconjug Chem. 2011 Oct 19;22(10):2179-85 [21899371] PLoS Negl Trop Dis. 2011 Oct;5(10):e1289 [22028938] Bull World Health Organ. 2012 Mar 1;90(3):209-218A [22461716] Clin Vaccine Immunol. 2012 Apr;19(4):594-602 [22357651] Expert Rev Anti Infect Ther. 2012 Apr;10(4):435-44 [22512753] Clin Vaccine Immunol. 2012 May;19(5):690-8 [22441386] Clin Vaccine Immunol. 2012 Jun;19(6):842-8 [22518009] Lancet. 2012 Jun 30;379(9835):2466-76 [22748592] Clin Vaccine Immunol. 2012 Aug;19(8):1304-11 [22739692] Carbohydr Res. 2001 Feb 28;330(4):479-86 [11269399] Infect Immun. 2001 May;69(5):3488-93 [11292781] Infect Immun. 2001 Jun;69(6):3581-90 [11349017] Bull World Health Organ. 1968;38(3):327-34 [5302327] J Infect Dis. 1970 May;121:Suppl 121:1-9 [4912069] J Infect Dis. 1981 Jun;143(6):818-20 [7252264] Infect Immun. 1984 Sep;45(3):582-91 [6332076] J Infect Dis. 1985 Feb;151(2):236-42 [3968450] Infect Immun. 1992 Aug;60(8):3201-8 [1639490] Biochem Biophys Res Commun. 1993 Nov 15;196(3):1309-15 [7504475] J Infect Dis. 1994 Mar;169(3):709-10 [8158063] Carbohydr Res. 1994 Mar 18;256(1):113-28 [8194067] Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11388-92 [7972070] Infect Immun. 1995 Jan;63(1):317-23 [7528734] EMBO J. 1995 Jan 16;14(2):209-16 [7835331] Infect Immun. 1996 Jan;64(1):10-5 [8557325] Glycoconj J. 1996 Apr;13(2):315-9 [8737256] Carbohydr Res. 1996 Aug 26;290(1):59-65 [8805782] Infect Immun. 1996 Oct;64(10):4373-7 [8926115] J Immunol Methods. 1996 Nov 29;199(1):37-46 [8960096] Infect Immun. 1997 Jul;65(7):2941-9 [9199470] Infect Immun. 1997 Aug;65(8):3118-25 [9234763] Infect Immun. 1997 Sep;65(9):3571-6 [9284121] J Biol Chem. 1998 Jan 30;273(5):2777-83 [9446585] Infect Immun. 1998 Jul;66(7):3095-9 [9632571] Nature. 2005 Aug 4;436(7051):696-700 [16079845] FEMS Immunol Med Microbiol. 2006 Nov;48(2):237-51 [17010106] Carbohydr Res. 2008 Feb 4;343(2):196-210 [18048016] PLoS Negl Trop Dis. 2008;2(2):e173 [18299707] PLoS Negl Trop Dis. 2008;2(4):e221 [18398491] Am J Trop Med Hyg. 2008 Nov;79(5):708-14 [18981509] Infect Immun. 2000 Sep;68(9):5037-43 [10948122] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1371/journal.pntd.0002683 ER - TY - JOUR T1 - In vitro activity of temocillin against multidrug-resistant clinical isolates of Escherichia coli, Klebsiella spp. and Enterobacter spp., and evaluation of high-level temocillin resistance as a diagnostic marker for OXA-48 carbapenemase AN - 1496898816; 19021977 JF - Journal of Antimicrobial Chemotherapy AU - Woodford, Neil AU - Pike, Rachel AU - Meunier, Daniele AU - Loy, Richard AU - Hill, Robert AU - Hopkins, Katie L AD - Corresponding author. Tel: +44-20-8327-7255, neil.woodford@phe.gov.uk Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 564 EP - 567 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 69 IS - 2 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Clinical isolates KW - Temocillin KW - Enterobacter KW - A:01340 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496898816?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=In+vitro+activity+of+temocillin+against+multidrug-resistant+clinical+isolates+of+Escherichia+coli%2C+Klebsiella+spp.+and+Enterobacter+spp.%2C+and+evaluation+of+high-level+temocillin+resistance+as+a+diagnostic+marker+for+OXA-48+carbapenemase&rft.au=Woodford%2C+Neil%3BPike%2C+Rachel%3BMeunier%2C+Daniele%3BLoy%2C+Richard%3BHill%2C+Robert%3BHopkins%2C+Katie+L&rft.aulast=Woodford&rft.aufirst=Neil&rft.date=2014-02-01&rft.volume=69&rft.issue=2&rft.spage=564&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkt383 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2014-02-21 N1 - SubjectsTermNotLitGenreText - Temocillin; Enterobacter DO - http://dx.doi.org/10.1093/jac/dkt383 ER - TY - JOUR T1 - Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. AN - 1494302896; 24194395 AB - Sertraline is generally used for the treatment of depression and is also approved for the treatment of panic, obsessive-compulsive, and posttraumatic stress disorders. Previously, using rat primary hepatocytes and isolated mitochondria, we demonstrated that sertraline caused hepatic cytotoxicity and mitochondrial impairment. In the current study, we investigated and characterized molecular mechanisms of sertraline toxicity in human hepatoma HepG2 cells. Sertraline decreased cell viability and induced apoptosis in a dose- and time-dependent manner. Sertraline activated the intrinsic checkpoint protein caspase-9 and caused the release of cytochrome c from mitochondria to cytosol; this process was Bcl-2 family dependent because antiapoptotic Bcl-2 family proteins were decreased. Pretreatment of the HepG2 cells with caspase-3, caspase-8, and caspase-9 inhibitors partially but significantly reduced the release of lactate dehydrogenase, indicating that sertraline-induced apoptosis is mediated by both intrinsic and extrinsic apoptotic pathways. Moreover, sertraline markedly increased the expression of tumor necrosis factor (TNF) and the phosphorylation of JNK, extracellular signal-regulated kinase (ERK1/2), and p38. In sertraline-treated cells, the induction of apoptosis and cell death was shown to be the result of activation of JNK, but not ERK1/2 or p38 in the mitogen-activated protein kinase (MAPK) pathway. Furthermore, silencing MAP4K4, the upstream kinase of JNK, attenuated both apoptosis and cell death caused by sertraline. Taken together, our findings suggest that sertraline induced apoptosis in HepG2 cells at least partially via activation of the TNF-MAP4K4-JNK cascade signaling pathway. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Chen, Si AU - Xuan, Jiekun AU - Wan, Liqing AU - Lin, Haixia AU - Couch, Letha AU - Mei, Nan AU - Dobrovolsky, Vasily N AU - Guo, Lei AD - * Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079; Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 404 EP - 415 VL - 137 IS - 2 KW - Antidepressive Agents KW - 0 KW - Intracellular Signaling Peptides and Proteins KW - Proto-Oncogene Proteins c-bcl-2 KW - MAP4K4 protein, human KW - EC 2.7.1.11 KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - Caspase 3 KW - EC 3.4.22.- KW - Caspase 7 KW - Caspase 9 KW - Sertraline KW - QUC7NX6WMB KW - Index Medicus KW - cell death KW - apoptosis KW - MAPK pathway. KW - sertraline KW - liver toxicity KW - mitochondrial dysfunction KW - Real-Time Polymerase Chain Reaction KW - Caspase 7 -- metabolism KW - Gene Silencing KW - Humans KW - Cell Culture Techniques KW - Protein-Serine-Threonine Kinases -- genetics KW - Protein-Serine-Threonine Kinases -- antagonists & inhibitors KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Blotting, Western KW - Membrane Potential, Mitochondrial -- drug effects KW - Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors KW - Caspase 9 -- metabolism KW - Hep G2 Cells KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Caspase 3 -- metabolism KW - MAP Kinase Signaling System -- drug effects KW - Apoptosis -- drug effects KW - Antidepressive Agents -- toxicity KW - Sertraline -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1494302896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Sertraline%2C+an+antidepressant%2C+induces+apoptosis+in+hepatic+cells+through+the+mitogen-activated+protein+kinase+pathway.&rft.au=Chen%2C+Si%3BXuan%2C+Jiekun%3BWan%2C+Liqing%3BLin%2C+Haixia%3BCouch%2C+Letha%3BMei%2C+Nan%3BDobrovolsky%2C+Vasily+N%3BGuo%2C+Lei&rft.aulast=Chen&rft.aufirst=Si&rft.date=2014-02-01&rft.volume=137&rft.issue=2&rft.spage=404&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=1096-0929&rft_id=info:doi/10.1093%2Ftoxsci%2Fkft254 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-22 N1 - Date created - 2014-02-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1093/toxsci/kft254 ER - TY - JOUR T1 - A subset of papillary thyroid carcinomas contain KRAS mutant subpopulations at levels above normal thyroid. AN - 1492679137; 22930660 AB - The molecular pathogenesis of papillary thyroid carcinoma (PTC) is largely attributed to chromosomal rearrangements and point mutations in genes within the MAPK pathway (i.e., BRAF and RAS). Despite KRAS being the 6th most frequently mutated gene for all cancers, the reported frequency in thyroid cancer is only 2%. This may be due, in part, to the use of insensitive mutation detection methods such as DNA sequencing. Therefore, using the sensitive and quantitative ACB-PCR approach, we quantified KRAS codon 12 GGT → GAT and GGT → GTT mutant fraction (MF) in 20 normal thyroid tissues, 17 primary PTC, 2 metastatic PTC, and 1 anaplastic thyroid carcinoma. We observed measurable levels of KRAS codon 12 GAT or GTT mutation in all normal thyroid tissues. For PTCs, 29.4% and 35.3% had KRAS codon 12 GAT and GTT MF above the 95% upper confidence interval for the corresponding MFs in normal thyroid. The highest observed KRAS codon 12 GTT MFs were associated with tumors with follicular characteristics and relatively high levels of tumor necrosis. The results indicate KRAS mutant subpopulations are present in a large number of thyroid tumors, a fact previously unrecognized. The presence of KRAS mutation may indicate a tumor with an aggressive phenotype, thus directing the course of clinical treatment. © 2012 Wiley Periodicals, Inc. JF - Molecular carcinogenesis AU - Myers, Meagan B AU - McKim, Karen L AU - Parsons, Barbara L AD - Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas. Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 159 EP - 167 VL - 53 IS - 2 KW - Codon KW - 0 KW - KRAS protein, human KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - ras Proteins KW - Index Medicus KW - ACB-PCR KW - oncogenes KW - mutation KW - cancer genetics KW - cancer biomarkers KW - Young Adult KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Thyroid Gland -- metabolism KW - ras Proteins -- genetics KW - Proto-Oncogene Proteins -- biosynthesis KW - Thyroid Neoplasms -- genetics KW - Thyroid Neoplasms -- metabolism KW - ras Proteins -- biosynthesis KW - Proto-Oncogene Proteins -- genetics KW - Carcinoma, Papillary -- metabolism KW - Carcinoma -- metabolism KW - Mutation KW - Carcinoma, Papillary -- genetics KW - Carcinoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492679137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=A+subset+of+papillary+thyroid+carcinomas+contain+KRAS+mutant+subpopulations+at+levels+above+normal+thyroid.&rft.au=Myers%2C+Meagan+B%3BMcKim%2C+Karen+L%3BParsons%2C+Barbara+L&rft.aulast=Myers&rft.aufirst=Meagan&rft.date=2014-02-01&rft.volume=53&rft.issue=2&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=1098-2744&rft_id=info:doi/10.1002%2Fmc.21953 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-03-25 N1 - Date created - 2014-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/mc.21953 ER - TY - JOUR T1 - Bioequivalence accomplishments, ongoing initiatives, and remaining challenges. AN - 1490772569; 23841644 AB - Although bioequivalence (BE) concepts date back to the late 1960s, there has been a steady evolution in the tools applied to the assessment of product comparability. Despite these advancements, we continue to face a multitude of unresolved challenges. Several of these challenges are unique to veterinary medicine due to issues such as multiple species approvals, unique dosage forms (e.g., intramammary infusion and medicated premixes), physiological challenges (e.g., limitations in blood volume and stress reactions), and the need to evaluate product equivalence for products intended to release drug over a duration of months. Thus, while in some instances, we can adopt advancements implemented by our human health counterparts but in other situations, we need to pioneer our own method for resolving these challenges. The purpose of this manuscript is to provide an update on recent advances, achievements, and ongoing initiatives associated with the assessment of product BE in veterinary medicine. This review reflects the highlights of a presentation given at the 2012 meeting of the European Association for Veterinary Pharmacology and Toxicology. Published (2013). This article is a U.S. Government work and is in the public domain in the USA. JF - Journal of veterinary pharmacology and therapeutics AU - Martinez, M N AD - US Food and Drug Administration, Center for Veterinary Medicine, Rockville, MD, USA. Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 2 EP - 12 VL - 37 IS - 1 KW - Veterinary Drugs KW - 0 KW - Index Medicus KW - Therapeutic Equivalency KW - Animals KW - Species Specificity KW - Veterinary Drugs -- pharmacokinetics KW - Veterinary Medicine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1490772569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+veterinary+pharmacology+and+therapeutics&rft.atitle=Bioequivalence+accomplishments%2C+ongoing+initiatives%2C+and+remaining+challenges.&rft.au=Martinez%2C+M+N&rft.aulast=Martinez&rft.aufirst=M&rft.date=2014-02-01&rft.volume=37&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Journal+of+veterinary+pharmacology+and+therapeutics&rft.issn=1365-2885&rft_id=info:doi/10.1111%2Fjvp.12063 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-29 N1 - Date created - 2014-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1111/jvp.12063 ER -