TY - JOUR T1 - High efficiency transfection of embryonic limb mesenchyme with plasmid DNA using square wave pulse electroporation and sucrose buffer AN - 1654675898; PQ0001055386 AB - Micromass cultures of primary embryonic limb mesenchyme are a valuable model system for studying cartilage formation in vitro. However, high efficiency introduction of plasmid DNA into this hard-to-transfect cell type typically results in considerable cell death and significantly impeded chondrogenesis when the cells are subsequently plated in high density micromass. Here, we describe a novel method in which square wave pulse electroporation of chick embryo wing bud mesenchyme suspended in protective sucrose buffer results in high efficiency transfection without substantially affecting micromass culture cell viability or chondrogenic differentiation potential. Furthermore, we show that this protocol can be employed, along with effector gene expression vectors, to generate observable changes in the amount of cartilage tissue formed in micromass, unlike lower efficiency, higher cytotoxicity techniques that require co-transfection of reporter plasmids to monitor changes in the extent of chondrogenesis and correct for differences in cell viability. JF - BioTechniques AU - Bobick, Brent E AU - Alexander, Peter G AU - Tuan, Rocky S AD - Department of Health and Human Services, Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD; Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 85 EP - 89 PB - Eaton Publishing Co., One Research Drive, Suite 400A Westboro MA 01581 United States VL - 56 IS - 2 SN - 0736-6205, 0736-6205 KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Electroporation KW - Cartilage KW - Wings KW - Cell culture KW - Plasmids KW - Gene expression KW - Expression vectors KW - Cell death KW - Cytotoxicity KW - Limbs KW - Transfection KW - Sucrose KW - DNA KW - Waves KW - Embryos KW - Mesenchyme KW - Chondrogenesis KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1654675898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioTechniques&rft.atitle=High+efficiency+transfection+of+embryonic+limb+mesenchyme+with+plasmid+DNA+using+square+wave+pulse+electroporation+and+sucrose+buffer&rft.au=Bobick%2C+Brent+E%3BAlexander%2C+Peter+G%3BTuan%2C+Rocky+S&rft.aulast=Bobick&rft.aufirst=Brent&rft.date=2014-02-01&rft.volume=56&rft.issue=2&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=BioTechniques&rft.issn=07366205&rft_id=info:doi/10.2144%2F000114136 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-02-01 N1 - Last updated - 2016-04-29 N1 - SubjectsTermNotLitGenreText - Electroporation; Cartilage; Wings; Cell culture; Plasmids; Expression vectors; Gene expression; Cytotoxicity; Cell death; Limbs; Transfection; Sucrose; DNA; Embryos; Waves; Mesenchyme; Chondrogenesis DO - http://dx.doi.org/10.2144/000114136 ER - TY - JOUR T1 - Validation of the SDQ in a multi-ethnic population of young children AN - 1567045961; 201436877 AB - Background: The Strengths and Difficulties Questionnaire (SDQ) is a valuable screening tool for identifying psychosocial problems. Its performance in a multi-ethnic society, common to many paediatric health care workers, has not been investigated. Because it is important that screening instruments are valid and reliable for all ethnic groups within one society, we examined differences in the SDQ's psychometric properties in a multi-ethnic society. Methods: The SDQ parent (n = 8114) and teacher form (n = 9355) were completed as part of a preventive health check for children aged 5-6 years of Dutch and non-Dutch ethnic backgrounds. The Child Behaviour Checklist (CBCL)/Teacher Report Form (TRF) was administered to a subsample. Results: Factor analysis of the parent-rated SDQ showed different rating patterns for two of the five subscales for non-Dutch children as compared with Dutch children. Cronbach's alpha for the total difficulties score varied by ethnic group (0.73-0.78 parent-rated SDQ, 0.80-0.83 teacher-rated SDQ), and coefficients were generally smaller for non-Dutch than for Dutch children (P < 0.05). Alpha coefficients for subscales varied between 0.31-0.85 for ethnic groups. Inter-rater correlations between parents and teachers for the total difficulties score varied between 0.20-0.41 between ethnic groups and were larger for Dutch than for non-Dutch children (P < 0.05). Concurrent validity was acceptable for most scales and most ethnic groups. Conclusion: The total difficulties score of the parent- and teacher-rated SDQ is valid and reliable for different ethnic groups within Dutch society. However, there are differences in reliability and validity of the subscales, which makes interpretation of the subscales difficult for certain ethnic groups. Adapted from the source document. JF - European Journal of Public Health AU - Mieloo, Cathelijne L AU - Bevaart, Floor AU - Donker, Marianne C H AU - van Oort, Floor V A AU - Raat, Hein AU - Jansen, Wilma AD - 1 The Rotterdam-Rijnmond Public Health Service (GGD Rotterdam-Rijnmond), Rotterdam, The Netherlands Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 26 EP - 32 PB - Oxford University Press. UK VL - 24 IS - 1 SN - 1101-1262, 1101-1262 KW - Workers KW - Tests KW - Health KW - Teachers KW - Racial Differences KW - Parents KW - Netherlands KW - Children KW - Health Care Services KW - article KW - 1939: the family and socialization; adolescence & youth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1567045961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Public+Health&rft.atitle=Validation+of+the+SDQ+in+a+multi-ethnic+population+of+young+children&rft.au=Mieloo%2C+Cathelijne+L%3BBevaart%2C+Floor%3BDonker%2C+Marianne+C+H%3Bvan+Oort%2C+Floor+V+A%3BRaat%2C+Hein%3BJansen%2C+Wilma&rft.aulast=Mieloo&rft.aufirst=Cathelijne&rft.date=2014-02-01&rft.volume=24&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Public+Health&rft.issn=11011262&rft_id=info:doi/10.1093%2Feurpub%2Fckt100 LA - English DB - Sociological Abstracts N1 - Date revised - 2014-10-01 N1 - Last updated - 2016-09-28 N1 - CODEN - EJPHF6 N1 - SubjectsTermNotLitGenreText - Children; Netherlands; Teachers; Racial Differences; Parents; Tests; Health Care Services; Health; Workers DO - http://dx.doi.org/10.1093/eurpub/ckt100 ER - TY - JOUR T1 - Work-related spirometric restriction in flavoring manufacturing workers AN - 1560138122; 19431714 AB - Background Flavoring-exposed workers are at risk for occupational lung disease. Methods We examined serial spirometries from corporate medical surveillance of flavoring production workers to assess abnormality compared to the U.S. population; mean decline in forced expiratory volume in one second (FEV1) and forced vital capacity (FVC); and excessive declines in FEV1. Results Of 106 workers, 30 had spirometric restriction, 3 had obstruction, 1 had both, and 13 (of 70, 19%) had excessive declines in FEV1. The adjusted prevalence of restriction was 3.7 times expected. Employees with higher potential for flavorings exposure had 3.0 times and 2.4 times greater average annual declines in FEV1 and FVC respectively, and had 5.8 times higher odds of having excessive FEV1 declines than employees with lower potential for exposure. Conclusion Exposure-related spirometric abnormalities consistent with a restrictive process evolved during employment, suggesting that exposures in flavoring production are associated with a range of pathophysiology. Am. J. Ind. Med. 57:129-137, 2014. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Kreiss, Kathleen AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia. Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 129 EP - 137 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 2 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Health & Safety Science Abstracts KW - flavorings KW - diacetyl KW - hydrogen sulfide KW - spirometry KW - spirometric restriction KW - excessive decline KW - Risk assessment KW - USA KW - Occupational diseases KW - Employment KW - Occupational exposure KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560138122?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Work-related+spirometric+restriction+in+flavoring+manufacturing+workers&rft.au=Kreiss%2C+Kathleen&rft.aulast=Kreiss&rft.aufirst=Kathleen&rft.date=2014-02-01&rft.volume=57&rft.issue=2&rft.spage=129&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22282 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Occupational diseases; Employment; Occupational exposure; USA DO - http://dx.doi.org/10.1002/ajim.22282 ER - TY - JOUR T1 - Workplace mistreatment and sickness absenteeism from work: Results from the 2010 National Health Interview survey AN - 1560117878; 19431719 AB - Objective This study examined the association between workplace mistreatment and occurrence, duration, and costs of sickness absenteeism. Methods We used the 2010 National Health Interview Survey and considered 13,807 employed adult respondents. We used a zero-inflated negative binomial (zinb) model to examine the association between exposure to workplace mistreatment and the occurrence and number of workdays missed due to illness/injury in the preceding 12 months. Results In 2010, 7.6% of US workers employed at the time of the survey reported having been mistreated at their workplace. Both occurrence and duration of sickness absence were higher for mistreated than for non-mistreated workers. The zinb results showed that being mistreated was associated with a 42% increase in the number of missed workdays, controlling for covariates. The marginal effect analysis showed that lost workdays differed by 2.45 days between mistreated and non-mistreated workers. This implies that workplace mistreatment was associated with $4.1 billion, or 5.5%, of sickness absenteeism costs in 2010. Conclusions Workplace mistreatment is associated with sickness absence in the United States. While a causal relationship could not be established due to the cross-sectional design of the study, this study reveals the economic importance of developing workplace mistreatment prevention strategies. Am. J. Ind. Med. 57:202-213, 2014. Published 2013. This article is a U.S. Government work and is in the public domain in the USA. JF - American Journal of Industrial Medicine AU - Asfaw, Abay G AU - Chang, Chia C AU - Ray, Tapas K AD - Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Office of the Director, Washington, District of Columbia. Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 202 EP - 213 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 2 SN - 0271-3586, 0271-3586 KW - Health & Safety Science Abstracts KW - count data models KW - NHIS KW - sickness absenteeism KW - workplace mistreatment KW - USA KW - Prevention KW - Injuries KW - Economic importance KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560117878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Workplace+mistreatment+and+sickness+absenteeism+from+work%3A+Results+from+the+2010+National+Health+Interview+survey&rft.au=Asfaw%2C+Abay+G%3BChang%2C+Chia+C%3BRay%2C+Tapas+K&rft.aulast=Asfaw&rft.aufirst=Abay&rft.date=2014-02-01&rft.volume=57&rft.issue=2&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22273 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2014-10-02 N1 - SubjectsTermNotLitGenreText - Prevention; Injuries; Economic importance; Occupational exposure; USA DO - http://dx.doi.org/10.1002/ajim.22273 ER - TY - JOUR T1 - Non-robbery-related occupational homicides in the retail industry, 2003-2008 AN - 1560115702; 19431723 AB - Background The purpose of this study was to examine non-robbery-related occupational homicides in the retail industry from 2003 to 2008. Methods Data were abstracted from the Census of Fatal Occupational Injuries. Motive (robbery- or non-robbery-related) and workplace violence (WPV) typology (Type I-IV) were assigned using narrative text fields. Non-robbery-related homicide rates were calculated and compared among WPV types, demographic characteristics, and occupation. Results Twenty-eight percent of homicides that occurred in the retail industry were non-robbery-related. The leading event associated with non-robbery-related homicides was Type II (perpetrated by customers) (34%), followed by Type IV (perpetrated by personal relationship) (31%). The majority of homicides were due to arguments (50%). Security guards and workers in drinking establishments had the highest homicide rates per 100,000 workers (14.3 and 6.0, respectively). Conclusions Non-robbery-related homicides comprised a meaningful proportion of workplace homicides in the retail industry. Research is needed to develop strategies to prevent non-robbery-related homicides specifically. Am. J. Ind. Med. 57:245-253, 2014. copyright 2013 Wiley Periodicals, Inc. JF - American Journal of Industrial Medicine AU - Konda, Srinivas AU - Tiesman, Hope M AU - Hendricks, Scott AU - Gurka, Kelly K AD - Division of Safety Research, National Institute for Occupational Safety and Health, Analysis and Field Evaluations Branch, Morgantown, West Virginia. Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 245 EP - 253 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 United States VL - 57 IS - 2 SN - 0271-3586, 0271-3586 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - workplace violence KW - de-escalation KW - robbery KW - security guards KW - arguments KW - Drinking KW - Typology KW - Data processing KW - Injuries KW - Occupational safety KW - Violence KW - Demography KW - Security KW - Workers KW - Homicide KW - Census KW - Retail industry KW - Aggression KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1560115702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Non-robbery-related+occupational+homicides+in+the+retail+industry%2C+2003-2008&rft.au=Konda%2C+Srinivas%3BTiesman%2C+Hope+M%3BHendricks%2C+Scott%3BGurka%2C+Kelly+K&rft.aulast=Konda&rft.aufirst=Srinivas&rft.date=2014-02-01&rft.volume=57&rft.issue=2&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/10.1002%2Fajim.22283 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-09-01 N1 - Last updated - 2015-03-04 N1 - SubjectsTermNotLitGenreText - Drinking; Demography; Workers; Typology; Data processing; Injuries; Census; Aggression; Security; Homicide; Occupational safety; Retail industry; Violence DO - http://dx.doi.org/10.1002/ajim.22283 ER - TY - JOUR T1 - CHARACTERIZATION OF EXPOSURES TO WORKERS COVERED UNDER THE U.S. ENERGY EMPLOYEES COMPENSATION ACT AN - 1524400664; 19642288 AB - Since the mid-1940s, hundreds of thousands of workers have been engaged in nuclear weapons-related activities for the U.S. Department of Energy (DOE) and its predecessor agencies. In 2000, Congress promulgated the Energy Employees Occupational Illness Compensation Program Act of 2000 (EEOICPA), which provides monetary compensation and medical benefits to certain energy employees who have developed cancer. Under Part B of EEOICPA, the National Institute for Occupational Safety and Health (NIOSH) is required to estimate radiation doses for those workers who have filed a claim, or whose survivors have filed a claim, under Part B of the Act. To date, over 39,000 dose reconstructions have been completed for workers from more than 200 facilities. These reconstructions have included assessment of both internal and external exposure at all major DOE facilities, as well as at a large number of private companies [known as Atomic Weapons Employer (AWE) facilities in the Act] that engaged in contract work for the DOE and its predecessor agencies. To complete these dose reconstructions, NIOSH has captured and reviewed thousands of historical documents related to site operations and worker/workplace monitoring practices at these facilities. Using the data collected and reviewed pursuant to NIOSH's role under EEOICPA, this presentation will characterize historical internal and external exposures received by workers at DOE and AWE facilities. To the extent possible, use will be made of facility specific coworker models to highlight changes in exposure patterns over time. In addition, the effects that these exposures have on compensation rates for workers are discussed. JF - Health Physics AU - Neton, James W AD - Division of Compensation Analysis and Support, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Mail Stop C-46, Cincinnati, OH 45226, jneton@cdc.gov Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 249 EP - 258 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 106 IS - 2 SN - 0017-9078, 0017-9078 KW - Health & Safety Science Abstracts KW - dose reconstruction KW - exposure, radiation KW - health effects KW - National Council on Radiation Protection and Measurements KW - Historical account KW - USA KW - Weapons KW - Contracts KW - Radiation KW - Energy KW - Reviews KW - Congress KW - Economics KW - Occupational safety KW - Occupational exposure KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1524400664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=CHARACTERIZATION+OF+EXPOSURES+TO+WORKERS+COVERED+UNDER+THE+U.S.+ENERGY+EMPLOYEES+COMPENSATION+ACT&rft.au=Neton%2C+James+W&rft.aulast=Neton&rft.aufirst=James&rft.date=2014-02-01&rft.volume=106&rft.issue=2&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/10.1097%2FHP.0000000000000008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Historical account; Weapons; Radiation; Contracts; Congress; Reviews; Energy; Occupational safety; Economics; Occupational exposure; USA DO - http://dx.doi.org/10.1097/HP.0000000000000008 ER - TY - JOUR T1 - Screening Foods for Radionuclide Contamination Via Analysis of Composited Analytical Portions AN - 1520362255; 19642302 AB - A procedure is presented for screening foods for radionuclide contamination. It was developed by the U.S. Food and Drug Administration (U.S. FDA) to be an option for augmenting analytical capability following a major radiological contamination event involving beta- or alpha-emitting radionuclides. The expected application of this procedure would be during late-phase monitoring, after initial monitoring suggests an area is contamination-free or levels are negligible but additional confirming data are desired. The procedure involves combining equal-mass portions from a number (n) of food samples to make a composite analytical portion, which is then analyzed using a quantitative method. Instead of comparing results with the regulatory limit, they are compared with a screening level equal to 1/n of the regulatory limit. JF - Health Physics AU - Cunningham, William C AD - Division of Bioanalytical Chemistry, Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, william.cunningham@fda.hhs.gov Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - S16 EP - S19 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 United States VL - 106 IS - 2 SN - 0017-9078, 0017-9078 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - operational topics KW - contamination KW - emergencies KW - radiological KW - food chain KW - Composite materials KW - USA KW - Contamination KW - Radioisotopes KW - FDA KW - Drugs KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1520362255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Screening+Foods+for+Radionuclide+Contamination+Via+Analysis+of+Composited+Analytical+Portions&rft.au=Cunningham%2C+William+C&rft.aulast=Cunningham&rft.aufirst=William&rft.date=2014-02-01&rft.volume=106&rft.issue=2&rft.spage=S16&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2015-05-27 N1 - SubjectsTermNotLitGenreText - Composite materials; Contamination; FDA; Radioisotopes; Drugs; USA ER - TY - JOUR T1 - "Freezing" parasites in pre-Himalayan region, Himachal Pradesh: Experience with mini-FLOTAC AN - 1516753909; 19580425 AB - Background: Helminths and protozoa infections pose a great burden especially in developing, countries, due to morbidity caused both by acute and chronic infections. Data on distribution of intestinal parasitic infections among the native and expatriates populations in Himachal Pradesh are scarce. The aim of our survey was to analyze the intestinal parasitic burden in communities from Dharamsala, Kangra district, in clinical and public health settings. We also field-tested the mini- FLOTAC, an innovative diagnostic device. JF - Acta Tropica AU - Barda, Beatrice AU - Ianniello, Davide AU - Salvo, Fulvio AU - Sadutshang, Tsetan AU - Rinaldi, Laura AU - Cringoli, Giuseppe AU - Burioni, Roberto AU - Albonico, Marco Y1 - 2014/02/01/ PY - 2014 DA - 2014 Feb 01 SP - 11 EP - 16 PB - Elsevier B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands VL - 130 SN - 0001-706X, 0001-706X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; ASFA 3: Aquatic Pollution & Environmental Quality KW - STH KW - Himachal Pradesh KW - Helminths KW - Protozoa KW - Intestinal parasites KW - Parasites KW - Data processing KW - Freezing KW - Morbidity KW - Public health KW - Intestines KW - India, Himachal Pradesh KW - Chronic infection KW - Intestine KW - Developing countries KW - Q1 08485:Species interactions: pests and control KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1516753909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Tropica&rft.atitle=%22Freezing%22+parasites+in+pre-Himalayan+region%2C+Himachal+Pradesh%3A+Experience+with+mini-FLOTAC&rft.au=Barda%2C+Beatrice%3BIanniello%2C+Davide%3BSalvo%2C+Fulvio%3BSadutshang%2C+Tsetan%3BRinaldi%2C+Laura%3BCringoli%2C+Giuseppe%3BBurioni%2C+Roberto%3BAlbonico%2C+Marco&rft.aulast=Barda&rft.aufirst=Beatrice&rft.date=2014-02-01&rft.volume=130&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Acta+Tropica&rft.issn=0001706X&rft_id=info:doi/10.1016%2Fj.actatropica.2013.10.008 L2 - http://www.sciencedirect.com/science/article/pii/S0001706X13002854 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-04-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Parasites; Intestines; Freezing; Developing countries; Public health; Data processing; Protozoa; Chronic infection; Intestine; Morbidity; India, Himachal Pradesh DO - http://dx.doi.org/10.1016/j.actatropica.2013.10.008 ER - TY - JOUR T1 - The Health IT Regional Extension Center Program: Evolution and Lessons for Health Care Transformation AN - 1512195730; 201406141 AB - Assess the Regional Extension Center (REC) program's progress toward its goal of supporting over 100,000 providers in small, rural, and underserved practices to achieve meaningful use (MU) of an electronic health record (EHR). Data collected January 2010 through June 2013 via monitoring and evaluation of the 4-year REC program. Descriptive study of 62 REC programs. Primary data collected from RECs were merged with nine other datasets, and descriptive statistics of progress by practice setting and penetration of targeted providers were calculated. RECs recruited almost 134,000 primary care providers (PCPs), or 44 percent of the nation's PCPs; 86 percent of these were using an EHR with advanced functionality and almost half (48 percent) have demonstrated MU. Eighty-three percent of Federally Qualified Health Centers and 78 percent of the nation's Critical Access Hospitals were participating with an REC. RECs have made substantial progress in assisting PCPs with adoption and MU of EHRs. This infrastructure supports small practices, community health centers, and rural and public hospitals to use technology for care delivery transformation and improvement. Adapted from the source document. JF - Health Services Research AU - Lynch, Kimberly AU - Kendall, Mat AU - Shanks, Katherine AU - Haque, Ahmed AU - Jones, Emily AU - Wanis, Maggie G AU - Furukawa, Michael AU - Mostashari, Farzad AD - Office of the National Coordinator for Health IT. U.S. Department of Health and Human Services Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 421 EP - 437 PB - Blackwell Publishers, Oxford UK VL - 49 IS - 1pt2 SN - 0017-9124, 0017-9124 KW - Transformation KW - Care delivery KW - Underserved people KW - Health KW - Rural communities KW - Hospitals KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1512195730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=The+Health+IT+Regional+Extension+Center+Program%3A+Evolution+and+Lessons+for+Health+Care+Transformation&rft.au=Lynch%2C+Kimberly%3BKendall%2C+Mat%3BShanks%2C+Katherine%3BHaque%2C+Ahmed%3BJones%2C+Emily%3BWanis%2C+Maggie+G%3BFurukawa%2C+Michael%3BMostashari%2C+Farzad&rft.aulast=Lynch&rft.aufirst=Kimberly&rft.date=2014-02-01&rft.volume=49&rft.issue=1pt2&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2F1475-6773.12140 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Hospitals; Rural communities; Transformation; Health; Care delivery; Underserved people DO - http://dx.doi.org/10.1111/1475-6773.12140 ER - TY - JOUR T1 - Characterization of the meningococcal serogroup X capsule N-acetylglucosamine-1-phosphotransferase AN - 1505340805; 19266551 AB - Neisseria meningitidis serogroups A, B, C, Y, W135 and X are responsible for most cases of meningococcal meningitis. Neisseria meningitidis serogroup X has recently emerged as a contributor to outbreaks of disease in Africa, but there is currently no vaccine against serogroup X. Understanding of the biosynthesis of the serogroup X capsular polysaccharide would provide useful tools for vaccine production. The serogroup X polysaccharide is a homopolymer of ( alpha 1 arrow right 4)-linked N-acetylglucosamine (GlcNAc)-1-phosphate. It has been shown that the gene cluster xcbABC encodes synthesis of this polysaccharide. The xcbA gene product has significant homology with sacB, which is responsible for synthesis of the Neisseria serogroup A capsular polysaccharide, an ( alpha 1 arrow right 6)-N-acetylmannosamine-1-phospha te homopolymer. The xcbA protein also shares homology with the catalytic domain of human N-acetylglucosamine-1-phosphoryltransferase, a key enzyme in the mannose-6-phosphate receptor pathway. In this study, we show that xcbA in the appropriate background is sufficient for the synthesis of N. meningitidis serogroup X polysaccharide. By ELISA we detected polysaccharide in fractions of Escherichia coli expressing the xcbA gene. We isolated polysaccharide from an E. coli strain expressing XcbA and demonstrated that this polysaccharide has a super(13)C-NMR spectrum identical to that of polysaccharide isolated from N. meningitidis Group X. We also demonstrate that the purified XcbA protein is an N-acetylglucosamine-1-phosphotransferase that transfers N-acetylglucosamine-1-phosphate from UDP-GlcNAc to the 4-hydroxyl of an N-acetylglucosamine-1-phosphate oligosaccharide. Oligosaccharides fluorescently labeled at the aglycon are extended by XcbA only after the 4-phosphate occupying the non-reducing GlcNAc has been removed. The minimum size of fluorescent acceptors is a trisaccharide. JF - Glycobiology AU - Muindi, Karen M AU - McCarthy, Pumtiwitt C AU - Wang, Theresa AU - Vionnet, Justine AU - Battistel, Marcos AU - Jankowska, Ewa AU - Vann, Willie F AD - 2 Center for Biologics Evaluation and Research, Bethesda, MD 20892, USA, willie.vann@fda.hhs.gov Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 139 EP - 149 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 24 IS - 2 SN - 0959-6658, 0959-6658 KW - Microbiology Abstracts B: Bacteriology KW - Enzyme-linked immunosorbent assay KW - oligosaccharides KW - N-Acetylglucosamine-1-phosphate KW - Neisseria meningitidis KW - N-Acetylglucosamine KW - Meningitis KW - Homology KW - Gene clusters KW - Mannose-6-phosphate receptors KW - Escherichia coli KW - Vaccines KW - Capsular polysaccharides KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1505340805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glycobiology&rft.atitle=Characterization+of+the+meningococcal+serogroup+X+capsule+N-acetylglucosamine-1-phosphotransferase&rft.au=Muindi%2C+Karen+M%3BMcCarthy%2C+Pumtiwitt+C%3BWang%2C+Theresa%3BVionnet%2C+Justine%3BBattistel%2C+Marcos%3BJankowska%2C+Ewa%3BVann%2C+Willie+F&rft.aulast=Muindi&rft.aufirst=Karen&rft.date=2014-02-01&rft.volume=24&rft.issue=2&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Glycobiology&rft.issn=09596658&rft_id=info:doi/10.1093%2Fglycob%2Fcwt091 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; oligosaccharides; Homology; Mannose-6-phosphate receptors; Gene clusters; N-Acetylglucosamine-1-phosphate; N-Acetylglucosamine; Vaccines; Capsular polysaccharides; Meningitis; Escherichia coli; Neisseria meningitidis DO - http://dx.doi.org/10.1093/glycob/cwt091 ER - TY - JOUR T1 - ROUNDTABLE DISCUSSION: Reformulating Opioids to Deter Abuse AN - 1503760655 AB - Contributor Cindy H. Dubin talks with some leading Specialty Pharma companies to find out how they are formulating technologies to deter the growing problem of opioid abuse. JF - Drug Development & Delivery AU - story, Share this AU - of, The FDA "limitation AU - suggests, use" labeling language AU - products, that extended-release opioid-containing AU - used, should only be AU - have, when other alternatives AU - Do, not been successful AU - this, you think that AU - physicians, may eventually drive AU - immediate-release, to further prescribe AU - alternative, non-opioids as an AU - therapy, for chronic analgesic AU - Soscia, Mr AU - Andrew, Mr AU - Hakim, Mr AU - types, There are several AU - evaluated, of technologies being AU - ie, for abuse deterrence AU - technologies, prodrug How do AU - class, in the same AU - other, differentiate themselves from AU - may, from generics that AU - technologies, pursue competitors' AU - formulation, Describe your abuse-deterrent AU - to, how it works AU - maintain, deter abuse yet AU - effectiveness, patient AU - Radie, Mr AU - technology, How does your AU - proposed, satisfy the FDA's AU - requirements, abuse-deterrent labeling AU - safety, still promote patient AU - see, What do you AU - pros, as the AU - vs, cons of immediate-release AU - as, extended-release opioid formulations AU - abuse, they relate to AU - you'd, Is there anything AU - or, like to add AU - is, comment on that AU - above, not discussed Y1 - 2014///Jan/Feb PY - 2014 DA - Jan/Feb 2014 CY - Montville PB - Drug Development & Delivery SN - 23722770 KW - Pharmacy And Pharmacology KW - Pharmaceutical industry KW - Prescription drugs KW - Pain management KW - Narcotics KW - United States--US UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1503760655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Development+%26+Delivery&rft.atitle=ROUNDTABLE+DISCUSSION%3A+Reformulating+Opioids+to+Deter+Abuse&rft.au=story%2C+Share+this%3Bof%2C+The+FDA+%22limitation%3Bsuggests%2C+use%22+labeling+language%3Bproducts%2C+that+extended-release+opioid-containing%3Bused%2C+should+only+be%3Bhave%2C+when+other+alternatives%3BDo%2C+not+been+successful%3Bthis%2C+you+think+that%3Bphysicians%2C+may+eventually+drive%3Bimmediate-release%2C+to+further+prescribe%3Balternative%2C+non-opioids+as+an%3Btherapy%2C+for+chronic+analgesic%3BSoscia%2C+Mr%3BAndrew%2C+Mr%3BHakim%2C+Mr%3Btypes%2C+There+are+several%3Bevaluated%2C+of+technologies+being%3Bie%2C+for+abuse+deterrence%3Btechnologies%2C+prodrug+How+do%3Bclass%2C+in+the+same%3Bother%2C+differentiate+themselves+from%3Bmay%2C+from+generics+that%3Btechnologies%2C+pursue+competitors%27%3Bformulation%2C+Describe+your+abuse-deterrent%3Bto%2C+how+it+works%3Bmaintain%2C+deter+abuse+yet%3Beffectiveness%2C+patient%3BRadie%2C+Mr%3Btechnology%2C+How+does+your%3Bproposed%2C+satisfy+the+FDA%27s%3Brequirements%2C+abuse-deterrent+labeling%3Bsafety%2C+still+promote+patient%3Bsee%2C+What+do+you%3Bpros%2C+as+the%3Bvs%2C+cons+of+immediate-release%3Bas%2C+extended-release+opioid+formulations%3Babuse%2C+they+relate+to%3Byou%27d%2C+Is+there+anything%3Bor%2C+like+to+add%3Bis%2C+comment+on+that%3Babove%2C+not+discussed&rft.aulast=story&rft.aufirst=Share&rft.date=2014-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Drug+Development+%26+Delivery&rft.issn=23722770&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Name - Food & Drug Administration--FDA N1 - Copyright - Copyright Drug Development & Delivery Jan/Feb 2014 N1 - Last updated - 2015-03-05 N1 - SubjectsTermNotLitGenreText - United States--US ER - TY - JOUR T1 - Carbapenemase-producing Enterobacteriaceae and non-Enterobacteriaceae from animals and the environment: an emerging public health risk of our own making? AN - 1496898202; 19021997 AB - Acquired carbapenemases pose one of the most pressing public health threats relating to antibiotic resistance. In most countries, the number of carbapenemase-producing bacteria from human clinical specimens is rising, and the epidemiological status of these multiresistant bacteria is progressively worsening. Furthermore, there is a growing number of reports of carbapenemases found either in bacteria isolated from non-human sources or in Salmonella enterica subsp. enterica, a zoonotic species. However, carbapenemases are not yet systematically sought in bacteria from non-human sources, reports of them are largely observational, and there is limited investigation of carbapenemase-positive bacteria in animals and possible links with people who may have acted as potential sources. Active surveillance and monitoring for carbapenem-resistant bacteria in the food chain and other non-human sources is urgently needed, with an enhanced and rigorous follow-up of all positive results. The carbapenems are currently our last good defence against multiresistant Gram-negative bacteria. Our ability to limit the rise and spread of carbapenemase producers, which occur only at basal levels in many countries at present, should serve as a key performance indicator for the success or failure of the efforts that have been called for by international organizations and governments to reduce the impact of antibiotic resistance. JF - Journal of Antimicrobial Chemotherapy AU - Woodford, Neil AU - Wareham, David W AU - Guerra, Beatriz AU - Teale, Christopher AD - 1 Antimicrobial Resistance and Healthcare Associated Infections (AMRHAI) Reference Unit, Public Health England, London NW9 5EQ, UK, neil.woodford@phe.gov.uk Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 287 EP - 291 PB - Oxford University Press, Great Clarendon Street Oxford OX2 6DP United Kingdom VL - 69 IS - 2 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts; Health & Safety Science Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Animals KW - Food chains KW - Chemotherapy KW - Carbapenems KW - carbapenemase KW - Antimicrobial agents KW - Public health KW - Salmonella enterica KW - Gram-negative bacteria KW - International organizations KW - Enterobacteriaceae KW - Antibiotic resistance KW - J 02310:Genetics & Taxonomy KW - H 6000:Natural Disasters/Civil Defense/Emergency Management KW - A 01340:Antibiotics & Antimicrobials KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496898202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Carbapenemase-producing+Enterobacteriaceae+and+non-Enterobacteriaceae+from+animals+and+the+environment%3A+an+emerging+public+health+risk+of+our+own+making%3F&rft.au=Woodford%2C+Neil%3BWareham%2C+David+W%3BGuerra%2C+Beatriz%3BTeale%2C+Christopher&rft.aulast=Woodford&rft.aufirst=Neil&rft.date=2014-02-01&rft.volume=69&rft.issue=2&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/10.1093%2Fjac%2Fdkt392 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2014-04-17 N1 - SubjectsTermNotLitGenreText - Food chains; Gram-negative bacteria; International organizations; Carbapenems; carbapenemase; Antibiotic resistance; Public health; Animals; Chemotherapy; Antimicrobial agents; Salmonella enterica; Enterobacteriaceae DO - http://dx.doi.org/10.1093/jac/dkt392 ER - TY - JOUR T1 - Trauma-informed care in inpatient mental health settings: A review of the literature AN - 1496663797; 201403139 AB - Trauma-informed care is an emerging value that is seen as fundamental to effective and contemporary mental health nursing practice. Trauma-informed care, like recovery, leaves mental health nurses struggling to translate these values into day-to-day nursing practice. Many are confused about what individual actions they can take to support these values. To date, the most clearly articulated policy to emerge from the trauma-informed care movement in Australia has been the agreement to reduce, and wherever possible, eliminate the use of seclusion and restraint. Confronted with the constant churn of admissions and readmissions of clients with challenging behaviours, and seemingly intractable mental illness, the elimination of seclusion and restraint is seen to be utopian by many mental health nurses in inpatient settings. Is trauma-informed care solely about eliminating seclusion and restraint, or are there other tangible practices nurses could utilize to effect better health outcomes for mental health clients, especially those with significant abuse histories? This article summarizes the findings from the literature from 2000-2011 in identifying those practices and clinical activities that have been implemented to effect trauma-informed care in inpatient mental health settings. Adapted from the source document. JF - International Journal of Mental Health Nursing AU - Muskett, Coral AD - Department of Health and Human Services. State-Wide and Mental Health Services Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 51 EP - 59 PB - Blackwell Publishing Asia, Carlton South Australia VL - 23 IS - 1 SN - 1445-8330, 1445-8330 KW - Mental health services KW - Hospitalization KW - Restraints KW - Seclusion KW - Psychiatric nurses KW - Professional practices KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1496663797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Mental+Health+Nursing&rft.atitle=Trauma-informed+care+in+inpatient+mental+health+settings%3A+A+review+of+the+literature&rft.au=Muskett%2C+Coral&rft.aulast=Muskett&rft.aufirst=Coral&rft.date=2014-02-01&rft.volume=23&rft.issue=1&rft.spage=51&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Mental+Health+Nursing&rft.issn=14458330&rft_id=info:doi/10.1111%2Finm.12012 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2014-02-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Seclusion; Hospitalization; Restraints; Professional practices; Psychiatric nurses; Mental health services DO - http://dx.doi.org/10.1111/inm.12012 ER - TY - JOUR T1 - Inhibition of pathogenic bacterial biofilm by biosurfactant produced by Lysinibacillus fusiformis S9 AN - 1492831167; 23719930 AB - A biosurfactant producing microbe isolated from a river bank was identified as Lysinibacillus fusiformis S9. It was identified with help of biochemical tests and 16S rRNA gene phylogenetic analysis. The biosurfactant S9BS produced was purified and characterized as glycolipid. The biosurfactant showed remarkable inhibition of biofilm formation by pathogenic bacteria like Escherichia coli and Streptococcus mutans. It was interesting to note that at concentration of 40 [mu]g ml^sup -1^ the biosurfactant did not show any bactericidal activity but restricted the biofilm formation completely. L. fusiformis is reported for the first time to produce a glycolipid type of biosurfactant capable of inhibiting biofilm formation by pathogenic bacteria. The biosurfactant inhibited bacterial attachment and biofilm formation equally well on hydrophilic as well as hydrophobic surfaces like glass and catheter tubing. This property is significant in many biomedical applications where the molecule should help in preventing biofouling of surfaces without being toxic to biotic system.[PUBLICATION ABSTRACT] JF - Bioprocess and Biosystems Engineering AU - Pradhan, Arun Kumar AU - Pradhan, Nilotpala AU - Sukla, Lala Behari AU - Panda, Prasanna Kumar AU - Mishra, Barda Kanta Y1 - 2014/02// PY - 2014 DA - Feb 2014 SP - 139 EP - 49 CY - Heidelberg PB - Springer Science & Business Media VL - 37 IS - 2 SN - 16157591 KW - Engineering--Chemical Engineering KW - Culture Media KW - RNA, Ribosomal, 16S KW - Surface-Active Agents KW - Pathogens KW - Bacteria KW - Biofilms KW - Surfactants KW - Glycosylation KW - Lipids KW - Phylogeny KW - Spectroscopy, Fourier Transform Infrared KW - Base Sequence KW - Bacillaceae -- genetics KW - RNA, Ribosomal, 16S -- genetics KW - Molecular Sequence Data KW - Surface-Active Agents -- pharmacology KW - Magnetic Resonance Spectroscopy KW - Bacillaceae -- classification KW - Bacillaceae -- metabolism KW - Biofilms -- drug effects KW - Surface-Active Agents -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492831167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=DAFS%3A+a+data-adaptive+flag+method+for+RNA-sequencing+data+to+differentiate+genes+with+low+and+high+expression&rft.au=George%2C+Nysia+I%3BChang%2C+Ching-Wei&rft.aulast=George&rft.aufirst=Nysia&rft.date=2014-01-01&rft.volume=15&rft.issue=1&rft.spage=92&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-15-92 LA - English DB - ProQuest Central N1 - Copyright - Springer-Verlag Berlin Heidelberg 2014 N1 - Last updated - 2014-10-01 DO - http://dx.doi.org/10.1007/s00449-013-0976-5 ER - TY - JOUR T1 - Neurovascular changes in acute, sub-acute and chronic mouse models of Parkinson's disease. AN - 1492721160; 24274908 AB - Although selective neurodegeneration of nigro-striatal dopaminergic neurons is widely accepted as a cause of Parkinson's disease (PD), the role of vascular components in the brain in PD pathology is not well understood. However, the neurodegeneration seen in PD is known to be associated with neuroinflammatory-like changes that can affect or be associated with brain vascular function. Thus, dysfunction of the capillary endothelial cell component of neurovascular units present in the brain may contribute to the damage to dopaminergic neurons that occurs in PD. An animal model of PD employing acute, sub-acute and chronic exposures of mice to methyl-phenyl-tetrahydropyridine (MPTP) was used to determine the extent to which brain vasculature may be damaged in PD. Fluoro-Turquoise gelatin labeling of microvessels and endothelial cells was used to determine the extent of vascular damage produced by MPTP. In addition, tyrosine hydroxylase (TH) and NeuN were employed to detect and quantify dopaminergic neuron damage in the striatum (CPu) and substantia nigra (SNc). Gliosis was evaluated through GFAP immunohistochemistry. MPTP treatment drastically reduced TH immunoreactive neurons in the SNc (20.68 ± 2.83 in acute; 22.98 ± 2.14 in sub-acute; 10.20 ± 2.24 in chronic vs 34.88 ± 2.91 in controls; p<0.001). Similarly, TH immunoreactive terminals were dramatically reduced in the CPu of MPTP treated mice. Additionally, all three MPTP exposures resulted in a decrease in the intensity, length, and number of vessels in both CPu and SNc. Degenerative vascular changes such as endothelial cell 'clusters' were also observed after MPTP suggesting that vasculature damage may be modifying the availability of nutrients and exposing blood cells and/or toxic substances to neurons and glia. In summary, vascular damage and degeneration could be an additional exacerbating factor in the progression of PD, and therapeutics that protect and insure vascular integrity may be novel treatments for PD. JF - Current neurovascular research AU - Sarkar, Sumit AU - Raymick, James AU - Mann, Dushyant AU - Bowyer, John F AU - Hanig, Joseph P AU - Schmued, Larry C AU - Paule, Merle G AU - Chigurupati, Srinivasulu AD - Division of Neurotoxicology, National Center for Toxicological Research/FDA, Bldg. 53D, HFT-32, Jefferson-AR-72079, USA. Sumit.Sarkar@FDA.hhs.gov. Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 48 EP - 61 VL - 11 IS - 1 KW - 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt KW - 0 KW - Glial Fibrillary Acidic Protein KW - Stilbamidines KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - Phosphopyruvate Hydratase KW - EC 4.2.1.11 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Analysis of Variance KW - Phosphopyruvate Hydratase -- metabolism KW - Mice, Inbred C57BL KW - Glial Fibrillary Acidic Protein -- metabolism KW - Disease Models, Animal KW - Mice KW - Time Factors KW - Male KW - Brain -- pathology KW - Parkinsonian Disorders -- chemically induced KW - Cerebral Ventricles -- pathology KW - Parkinsonian Disorders -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492721160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+neurovascular+research&rft.atitle=Neurovascular+changes+in+acute%2C+sub-acute+and+chronic+mouse+models+of+Parkinson%27s+disease.&rft.au=Sarkar%2C+Sumit%3BRaymick%2C+James%3BMann%2C+Dushyant%3BBowyer%2C+John+F%3BHanig%2C+Joseph+P%3BSchmued%2C+Larry+C%3BPaule%2C+Merle+G%3BChigurupati%2C+Srinivasulu&rft.aulast=Sarkar&rft.aufirst=Sumit&rft.date=2014-02-01&rft.volume=11&rft.issue=1&rft.spage=48&rft.isbn=&rft.btitle=&rft.title=Current+neurovascular+research&rft.issn=1875-5739&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-18 N1 - Date created - 2014-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Systemic administration of fluoro-gold for the histological assessment of vascular structure, integrity and damage. AN - 1492720096; 24274907 AB - Fluoro-Gold (F-G) has been used extensively as a fluorescent retrograde neuronal-track tracer in the past. We now report that intraperitoneal administration of 10 to 30 mg/ kg of F-G from 30 min to 7 days prior to sacrifice labels vascular endothelial cells of the brain, choroid plexus and meninges and can be used to assess vascular integrity and damage. F-G vascular labeling co-localized with rat endothelial cell antigen (RECA-1) in the membrane. F-G also intensely labeled the nuclei of the endothelial cells, and co-localized with propidium iodide staining of these nuclei. As well, the administration of F-G during neurotoxic insults produced by amphetamine, kainic acid or "penetrating" wound to the brain can detect where vascular leakage/ hemorrhage has occurred. Histological methods to detect F-G labeled brain vasculature were performed in the same manner as that used for fluorescent visualization of neuronal elements labeled with F-G after perfusion fixation and coronal sectioning (15 to 40 µm) of the brain. This in vivo F-G labeling of endothelial cells and their nuclei yields a clear picture of the integrity of the vasculature and can be used to detect changes in structure. Vascular leaks after "penetrating" wounds through the cortex and striatum, hyperthermic amphetamine exposure or excitotoxic kainate exposure were detected by F-G in the extracellular space and via parenchymal F-G subsequently labeling the terminals and neurons adjacent to the lesioned or damaged vasculature. Further studies are necessary to determine the extent of the leakage necessary to detect vasculature damage. Visualization of the F-G labeling of vasculature structure and leakage is compatible with standard fluorescent immuno-labeling methods used to detect the presence and distribution of a protein in histological sections. This method should be directly applicable to studying brain vascular damage that occurs in the progression of Alzheimer's disease, diabetes and for monitoring the brain vascular changes during development. JF - Current neurovascular research AU - Bowyer, John F AU - Tranter, Karen M AU - Sarkar, Sumit AU - Raymick, James AU - Hanig, Joseph P AU - Schmued, Larry C AD - National Center for Toxicological Research/FDA, 3900 NCTR Road, HFT-132, Jefferson, AR- 72079, USA. john.bowyer@fda.hhs.gov. Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 31 EP - 47 VL - 11 IS - 1 KW - 2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt KW - 0 KW - Aif1 protein, rat KW - Calcium-Binding Proteins KW - Cell Adhesion Molecules KW - Esam protein, rat KW - Excitatory Amino Acid Agonists KW - Microfilament Proteins KW - Stilbamidines KW - Propidium KW - 36015-30-2 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Animals KW - Microfilament Proteins -- metabolism KW - Dose-Response Relationship, Drug KW - Disease Models, Animal KW - Excitatory Amino Acid Agonists -- toxicity KW - Rats KW - Rats, Sprague-Dawley KW - Cell Adhesion Molecules -- metabolism KW - Calcium-Binding Proteins -- metabolism KW - Time Factors KW - Kainic Acid -- toxicity KW - Male KW - Status Epilepticus -- chemically induced KW - Wounds, Penetrating -- diagnosis KW - Brain -- pathology KW - Status Epilepticus -- pathology KW - Brain -- metabolism KW - Blood Vessels -- pathology KW - Stilbamidines -- administration & dosage KW - Choroid Plexus -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1492720096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+neurovascular+research&rft.atitle=Systemic+administration+of+fluoro-gold+for+the+histological+assessment+of+vascular+structure%2C+integrity+and+damage.&rft.au=Bowyer%2C+John+F%3BTranter%2C+Karen+M%3BSarkar%2C+Sumit%3BRaymick%2C+James%3BHanig%2C+Joseph+P%3BSchmued%2C+Larry+C&rft.aulast=Bowyer&rft.aufirst=John&rft.date=2014-02-01&rft.volume=11&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Current+neurovascular+research&rft.issn=1875-5739&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-09-18 N1 - Date created - 2014-01-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - 'Are we there yet?' - operationalizing the concept of Integrated Public Health Policies. AN - 1490898069; 24210088 AB - Although 'integrated' public health policies are assumed to be the ideal way to optimize public health, it remains hard to determine how far removed we are from this ideal, since clear operational criteria and defining characteristics are lacking. A literature review identified gaps in previous operationalizations of integrated public health policies. We searched for an approach that could fill these gaps. We propose the following defining characteristics of an integrated policy: (1) the combination of policies includes an appropriate mix of interventions that optimizes the functioning of the behavioral system, thus ensuring that motivation, capability and opportunity interact in such a way that they promote the preferred (health-promoting) behavior of the target population, and (2) the policies are implemented by the relevant policy sectors from different policy domains. Our criteria should offer added value since they describe pathways in the process towards formulating integrated policy. The aim of introducing our operationalization is to assist policy makers and researchers in identifying truly integrated cases. The Behavior Change Wheel proved to be a useful framework to develop operational criteria to assess the current state of integrated public health policies in practice. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. JF - Health policy (Amsterdam, Netherlands) AU - Hendriks, Anna-Marie AU - Habraken, Jolanda AU - Jansen, Maria W J AU - Gubbels, Jessica S AU - De Vries, Nanne K AU - van Oers, Hans AU - Michie, Susan AU - Atkins, L AU - Kremers, Stef P J AD - Academic Collaborative Centre for Public Health Limburg, Regional Public Health Service, Geleen, The Netherlands; Department of Health Promotion, Caphri, School of Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands. Electronic address: anna-marie.hendriks@maastrichtuniversity.nl. ; Tranzo, Scientific Center for Care and Welfare, Tilburg University, Tilburg, The Netherlands. ; Academic Collaborative Centre for Public Health Limburg, Regional Public Health Service, Geleen, The Netherlands; Department of Health Services Research, Caphri, School of Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands. ; Department of Health Promotion, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands. ; Department of Health Promotion, Caphri, School of Public Health and Primary Care, Maastricht University, Maastricht, The Netherlands; Department of Health Promotion, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht University, Maastricht, The Netherlands. ; Tranzo, Scientific Center for Care and Welfare, Tilburg University, Tilburg, The Netherlands; National Institute for Public Health and the Environment, Bilthoven, The Netherlands. ; University College London, Division of Psychology, London, United Kingdom. ; Centre for Outcomes Research and Effectiveness, University College London, United Kingdom. Y1 - 2014/02// PY - 2014 DA - February 2014 SP - 174 EP - 182 VL - 114 IS - 2-3 KW - Health administration KW - Health in all policies KW - Whole-of-government approach KW - Integrated public health policies KW - Integrated approach KW - Healthy public policy KW - Intersectoral collaboration KW - Models, Organizational KW - Organizational Innovation KW - Humans KW - Organizational Culture KW - Diffusion of Innovation KW - Decision Making, Organizational KW - Interprofessional Relations KW - Policy Making KW - Delivery of Health Care, Integrated -- standards KW - Health Policy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1490898069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+policy+%28Amsterdam%2C+Netherlands%29&rft.atitle=%27Are+we+there+yet%3F%27+-+operationalizing+the+concept+of+Integrated+Public+Health+Policies.&rft.au=Hendriks%2C+Anna-Marie%3BHabraken%2C+Jolanda%3BJansen%2C+Maria+W+J%3BGubbels%2C+Jessica+S%3BDe+Vries%2C+Nanne+K%3Bvan+Oers%2C+Hans%3BMichie%2C+Susan%3BAtkins%2C+L%3BKremers%2C+Stef+P+J&rft.aulast=Hendriks&rft.aufirst=Anna-Marie&rft.date=2014-02-01&rft.volume=114&rft.issue=2-3&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Health+policy+%28Amsterdam%2C+Netherlands%29&rft.issn=1872-6054&rft_id=info:doi/10.1016%2Fj.healthpol.2013.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2015-04-09 N1 - Date created - 2014-01-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.healthpol.2013.10.004 ER - TY - JOUR T1 - Targeted analysis of multiple pharmaceuticals, plant toxins and other secondary metabolites in herbal dietary supplements by ultra-high performance liquid chromatography-quadrupole-orbital ion trap mass spectrometry AN - 1677907320; 19862876 AB - In this study, an ultra-high performance liquid chromatography-quadrupole-orbital ion trap mass spectrometry (UHPLC-Q-orbitrap MS) method was developed and validated for simultaneous determination of 96 pharmaceuticals, plant toxins, and other plant secondary metabolites in herbal dietary supplements. Target analytes were extracted from samples using the QuEChERS (quick easy cheap effective rugged safe) procedure. The instrument was operated in full MS-data dependent tandem mass spectrometry (full MS-dd-MS/MS) acquisition mode which enabled collection of quantitative high resolution (HR) full mass spectral data and confirmatory HR MS/MS data in a single run. The method provided excellent selectivity in both lull MS and dd-MS/MS mode. Under optimized collision energy settings, product ion spectra containing both precursor and two or more product ions were obtained for most of the analytes. The procedure was used to examine commercial dietary supplements for the 96 analytes of interest. To the best of our knowledge, this is the first report of an integrated analysis and quantification of this wide range of compounds. JF - Analytica Chimica Acta AU - Vaclavik, Lukas AU - Krynitsky, Alexander J AU - Rader, Jeanne I AD - U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, 5100 Paint Branch Parkway, HFS-717, College Park. MD 20740, USA Y1 - 2014/01/31/ PY - 2014 DA - 2014 Jan 31 SP - 45 EP - 60 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 810 SN - 0003-2670, 0003-2670 KW - Solid State and Superconductivity Abstracts (SO); Environmental Engineering Abstracts (EN) KW - Dietary supplements KW - Pharmaceuticals KW - Plant toxins KW - Ultra-high performance liquid KW - chromatography KW - Quadrupole-orbitrap mass spectrometer KW - Chromatography KW - Mass spectrometry KW - Metabolites KW - Spectra KW - Toxins KW - Liquids KW - Mathematical analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1677907320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytica+Chimica+Acta&rft.atitle=Targeted+analysis+of+multiple+pharmaceuticals%2C+plant+toxins+and+other+secondary+metabolites+in+herbal+dietary+supplements+by+ultra-high+performance+liquid+chromatography-quadrupole-orbital+ion+trap+mass+spectrometry&rft.au=Vaclavik%2C+Lukas%3BKrynitsky%2C+Alexander+J%3BRader%2C+Jeanne+I&rft.aulast=Vaclavik&rft.aufirst=Lukas&rft.date=2014-01-31&rft.volume=810&rft.issue=&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Analytica+Chimica+Acta&rft.issn=00032670&rft_id=info:doi/10.1016%2Fj.aca.2013.12.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-07-01 N1 - Number of references - 43 N1 - Last updated - 2015-09-07 DO - http://dx.doi.org/10.1016/j.aca.2013.12.006 ER - TY - JOUR T1 - Role of epigenetic aberrations in the development and progression of human hepatocellular carcinoma. AN - 1464909505; 22306342 AB - Hepatocellular carcinoma (HCC) is one of the most lethal and prevalent cancers in humans. The molecular mechanisms leading to the development of HCC are extremely complicated and consist of prominent genetic, genomic, and epigenetic alterations. This review summarizes the current knowledge of the role of epigenetic aberrations, including changes in DNA methylation, histone modifications, and expression of microRNAs in the pathogenesis of HCC. It also emphasizes that identification of the underlying epigenetic alterations that drive cell transformation and promote development and progression of HCC is crucially important for understanding mechanisms of hepatocarcinogenesis, its detection, therapeutic intervention, and prevention. Published by Elsevier Ireland Ltd. JF - Cancer letters AU - Pogribny, Igor P AU - Rusyn, Ivan AD - Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, United States. Electronic address: igor.pogribny@fda.hhs.gov. Y1 - 2014/01/28/ PY - 2014 DA - 2014 Jan 28 SP - 223 EP - 230 VL - 342 IS - 2 KW - Biomarkers, Tumor KW - 0 KW - Histones KW - MicroRNAs KW - Index Medicus KW - Histone modifications KW - DNA methylation KW - Hepatocellular carcinoma KW - Animals KW - Liver Neoplasms, Experimental -- genetics KW - MicroRNAs -- genetics KW - Humans KW - Prognosis KW - Disease Progression KW - Predictive Value of Tests KW - Gene Expression Regulation, Neoplastic KW - Phenotype KW - Genetic Testing KW - DNA Methylation KW - Histones -- metabolism KW - Genetic Predisposition to Disease KW - Cell Transformation, Neoplastic -- genetics KW - Biomarkers, Tumor -- genetics KW - Liver Neoplasms -- metabolism KW - Epigenesis, Genetic KW - Liver Neoplasms -- diagnosis KW - Biomarkers, Tumor -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- therapy KW - Carcinoma, Hepatocellular -- diagnosis KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- therapy KW - Carcinoma, Hepatocellular -- pathology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1464909505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Role+of+epigenetic+aberrations+in+the+development+and+progression+of+human+hepatocellular+carcinoma.&rft.au=Pogribny%2C+Igor+P%3BRusyn%2C+Ivan&rft.aulast=Pogribny&rft.aufirst=Igor&rft.date=2014-01-28&rft.volume=342&rft.issue=2&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=1872-7980&rft_id=info:doi/10.1016%2Fj.canlet.2012.01.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-01-30 N1 - Date created - 2013-12-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncologist. 2010;15 Suppl 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Biochim Biophys Acta. 2010 Aug;1806(1):50-7 [20398739] Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4140-9 [15217951] J Gastroenterol. 2004 Jun;39(6):563-9 [15235874] Nat Cell Biol. 2004 Aug;6(8):731-40 [15235609] Carcinogenesis. 2004 Sep;25(9):1779-86 [15073043] J Hepatol. 2004 Sep;41(3):436-45 [15336447] Cancer Res. 1992 Apr 1;52(7 Suppl):2071s-2077s [1544143] Adv Exp Med Biol. 1995;369:141-54 [7541179] J Biol Chem. 1998 Jan 30;273(5):2917-25 [9446603] Cancer Res. 1999 Jan 1;59(1):71-3 [9892188] Int J Cancer. 1999 Nov 12;83(4):541-6 [10508492] Clin Cancer Res. 2004 Nov 15;10(22):7484-9 [15569978] Int J Oncol. 2005 Feb;26(2):369-77 [15645121] Liver Int. 2005 Feb;25(1):16-27 [15698394] J Hepatol. 2005 Apr;42(4):511-9 [15763338] Liver Int. 2005 Apr;25(2):266-72 [15780049] Hum Mol Genet. 2005 Apr 15;14 Spec No 1:R139-47 [15809266] Br J Cancer. 2005 May 9;92(9):1754-8 [15856046] Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13580-5 [16174748] Oncogene. 2005 Sep 22;24(42):6406-17 [16007195] Genome Res. 2006 Feb;16(2):157-63 [16365381] Nature. 2006 Feb 16;439(7078):871-4 [16357870] Int J Oncol. 2006 May;28(5):1081-8 [16596223] Clin Biochem. 2006 Apr;39(4):344-8 [16527261] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1016/j.canlet.2012.01.038 ER - TY - RPRT T1 - CENTERS FOR DISEASE CONTROL AND PREVENTION ROYBAL CAMPUS 2025 MASTER PLAN, DEKALB COUNTY, GEORGIA. AN - 1553701898; 16008 AB - PURPOSE: A master plan to guide the future physical development of the CDCs Edward R. Roybal Campus for the planning horizon of 2015 to 2015 is proposed. The Roybal Campus is situated on 46.7 acres, just outside the city limits of the City of Atlanta in DeKalb County, Georgia. The campus is located between Interstate 85 and 20 and is located within the Clifton Corridor, which is a transportation corridor that extends along Clifton Road and includes a mix of neighborhoods, activity centers and thoroughfares within unincorporated DeKalb County, the City of Atlanta, and the City of Decatur. The Clifton Corridor represents one of the largest employment centers within the metro Atlanta area and is home to several major employers including the CDC, Emory University, Emory Healthcare, and the Veterans Affairs Medical Center. The Hartsfield-Jackson International Airport is located approximately 16 miles southwest of the campus. The Roybal Campus is located adjacent to Emory University and is surrounded by a mix of residential and institutional uses. Decatur Station, the closest MARTA station, is located approximately 2 miles southwest of the campus. The following eight Master Plan conceptual alternatives were evaluated for this draft EIS: (1) No Action, (2) Increase Space Efficiency, (3a) Lab-Office Mix Moderate, (3b) Lab-Office Full-Build, (4) Office Focus, (5a) Lab Focus Moderate, (5b) Lab Focus Full-Build, and (6) Relocation. Of the eight alternatives, two alternatives were deemed viable to be carried forward in the draft EIS for detailed analysis, the No Action and Lab Focus Moderate alternatives. The Lab Focus Moderate alternative, also the CDCs Preferred Alternative, includes new laboratory construction, building renovation, parking expansion, and additional improvements to campus infrastructure. The new laboratory building would measure approximately 350,000 to 450,000 gsf which would include approximately 60,000 gsf of below grade space. The new 1,600 space parking deck would be constructed in the southeastern portion of the campus, which currently consists of a surface parking lot and an existing transshipping facility. As part of the new parking deck construction, a new chilled water storage unit would be constructed in order to meet water usage reduction, energy reduction, and efficiency objectives. The No Action Alternative represented continued operation of the existing facilities at the Roybal Campus without any new construction of any major renovations of interiors or building additions over the ten-year planning period from 2015 to 2025. POSITIVE IMPACTS: Physical development of the Roybal Campus would: (1) accommodate current and future multi-program needs; (2) promote a collaborative research environment; (3) balance future development needs with site constraints and opportunities; and (4) promote overall visual and aesthetic continuity of the 2000-2009 Master Plan through the application of design guidelines for buildings. Implementation of the Preferred Alternative would increase the employee population by approximately 1,485 new occupants, from the current total of 5,308 to 6,793 in 2025. NEGATIVE IMPACTS: The Preferred Alternative would contribute to increased traffic within the Study Area which may affect fire and emergency response times. The Preferred Alternative would result in an increase in electricity, domestic water, natural gas consumption and sewage generation on campus, as well as increase the demand for steam and chilled water. JF - EPA number: 140012, Draft EIS--254 pages, Appendices--264 pages, January 24, 2014 PY - 2014 KW - Urban and Social Programs KW - Air Quality KW - Biologic Assessments KW - Demolition KW - Land Use KW - Buildings KW - Cultural Resources KW - Floodplains KW - Traffic Analyses KW - Noise KW - Parking KW - Public Health KW - Research Facilities KW - Safety KW - Visual Resources KW - Water Resources KW - Wetlands KW - Georgia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1553701898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/Environmental+Impact+Statements%3A+Digests&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=report&rft.jtitle=&rft.atitle=&rft.au=&rft.aulast=&rft.aufirst=&rft.date=2014-01-24&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=CENTERS+FOR+DISEASE+CONTROL+AND+PREVENTION+ROYBAL+CAMPUS+2025+MASTER+PLAN%2C+DEKALB+COUNTY%2C+GEORGIA.&rft.title=CENTERS+FOR+DISEASE+CONTROL+AND+PREVENTION+ROYBAL+CAMPUS+2025+MASTER+PLAN%2C+DEKALB+COUNTY%2C+GEORGIA.&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Name - Department of Health and Human Services, Center for Disease Control and Prevention, Atlanta, Georgia; HHS N1 - Date revised - 2014-08-01 N1 - SuppNotes - Draft. Preparation date: January 24, 2014 N1 - Last updated - 2014-08-18 ER - TY - RPRT T1 - Acute Illness Associated with Use of Pest Strips - Seven U.S. States and Canada, 2000-2013 AN - 1491429255; 24430101 AB - Dichlorvos-impregnated resin strips (DDVP pest strips) are among the few organophosphate products still available for indoor residential use. The residential uses for most other organophosphate products, including most DDVP products, were canceled because they posed unreasonable risks to children. DDVP pest strips act by inhibiting acetylcholinesterase activity in the brain and nerves of insect pests and are designed to gradually release DDVP vapor for up to 4 months. Acute illnesses in humans associated with nonlethal acute exposures usually resolve completely but recovery is not always rapid. To assess the frequency of acute illnesses associated with DDVP pest strips, cases from 2000 through June 2013 were sought from the 12 states that participate in the Sentinel Event Notification System for Occupational Risks-Pesticides Program, the National Pesticide Information Center, and Health Canada. A total of 31 acute DDVP pests trip-related illness cases were identified in seven US states and Canada. JF - MMWR. Morbidity and Mortality Weekly Report AU - Tsai, Rebecca J, PhD AU - Sievert, Jennifer AU - Prado, Joanne, MPH AU - Buhl, Kaci, MS AU - Stone, Dave L, PhD AU - Forrester, Mathias AU - Higgins, Sheila AU - Mitchell, Yvette, MS AU - Schwartz, Abby, MPH AU - Calvert, Geoffrey M, MD Y1 - 2014/01/17/ PY - 2014 DA - 2014 Jan 17 SP - 42 EP - 3 CY - Atlanta PB - U.S. Center for Disease Control KW - Public Health And Safety KW - Insecticides KW - Dichlorvos KW - Public health KW - Medical statistics KW - Human exposure KW - Pesticides KW - Disease KW - Canada KW - United States--US KW - Canada -- epidemiology KW - Young Adult KW - Product Labeling KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Insect Control -- methods KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Insecticides -- toxicity KW - Acute Disease -- epidemiology KW - Dichlorvos -- toxicity KW - Environmental Exposure -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1491429255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.atitle=Acute+Illness+Associated+with+Use+of+Pest+Strips+-+Seven+U.S.+States+and+Canada%2C+2000-2013&rft.au=Tsai%2C+Rebecca+J%2C+PhD%3BSievert%2C+Jennifer%3BPrado%2C+Joanne%2C+MPH%3BBuhl%2C+Kaci%2C+MS%3BStone%2C+Dave+L%2C+PhD%3BForrester%2C+Mathias%3BHiggins%2C+Sheila%3BMitchell%2C+Yvette%2C+MS%3BSchwartz%2C+Abby%2C+MPH%3BCalvert%2C+Geoffrey+M%2C+MD&rft.aulast=Tsai&rft.aufirst=Rebecca&rft.date=2014-01-17&rft.volume=63&rft.issue=2&rft.spage=42&rft.isbn=&rft.btitle=&rft.title=MMWR.+Morbidity+and+Mortality+Weekly+Report&rft.issn=01492195&rft_id=info:doi/ LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright U.S. Center for Disease Control Jan 17, 2014 N1 - Document feature - Tables; References N1 - Last updated - 2014-03-11 ER - TY - JOUR T1 - Aptamer Based, Non-PCR, Non-Serological Detection of Chagas Disease Biomarkers in Trypanosoma cruzi Infected Mice AN - 1505332871; 19052678 AB - Chagas disease affects about 5 million people across the world. The etiological agent, the intracellular parasite Trypanosoma cruzi (T. cruzi), can be diagnosed using microscopy, serology or PCR based assays. However, each of these methods has their limitations regarding sensitivity and specificity, and thus to complement these existing diagnostic methods, alternate assays need to be developed. It is well documented that several parasite proteins called T. cruzi Excreted Secreted Antigens (TESA), are released into the blood of an infected host. These circulating parasite antigens could thus be used as highly specific biomarkers of T. cruzi infection. In this study, we have demonstrated that, using a SELEx based approach, parasite specific ligands called aptamers, can be used to detect TESA in the plasma of T. cruzi infected mice. An Enzyme Linked Aptamer (ELA) assay, similar to ELISA, was developed using biotinylated aptamers to demonstrate that these RNA ligands could interact with parasite targets. Aptamer L44 (Apt-L44) showed significant and specific binding to TESA as well as T. cruzi trypomastigote extract and not to host proteins or proteins of Leishmania donovani, a related trypanosomatid parasite. Our result also demonstrated that the target of Apt-L44 is conserved in three different strains of T. cruzi. In mice infected with T. cruzi, Apt-L44 demonstrated a significantly higher level of binding compared to non-infected mice suggesting that it could detect a biomarker of T. cruzi infection. Additionally, Apt-L44 could detect these circulating biomarkers in both the acute phase, from 7 to 28 days post infection, and in the chronic phase, from 55 to 230 days post infection. Our results show that Apt-L44 could thus be used in a qualitative ELA assay to detect biomarkers of Chagas disease. Chagas disease, caused by the parasite Trypanosoma cruzi, is a major health concern for people living in Latin America. There are no vaccines to prevent this disease and only two drugs are prescribed for treatment. Current methods to diagnose patients are not always successful and thus new methods need to be developed. One approach to develop an alternate method is to detect proteins and metabolites that are secreted by parasites into the blood of infected individuals. We have utilized a selection based method to isolate ligands that bind to these secreted proteins. These ligands, called aptamers, have been used to develop an assay that can detect the circulating parasite targets in the plasma or serum of an infected host. In an animal model of Chagas disease, our assay can detect parasite biomarkers as early as seven days after infection and as late as 230 days post infection. As the laboratory instruments and procedures are similar to performing an ELISA, the aptamer assay reported here could be easily performed at diagnostic facilities. Further improvement in this assay can lead to a new quantitative diagnostic test for Chagas disease. A similar selection based approach could also be used to develop ligands for the detection of biomarkers in other diseases. JF - PLoS Neglected Tropical Diseases AU - Nagarkatti, Rana AU - de Araujo, Fernanda Fortes AU - Gupta, Charu AU - Debrabant, Alain AD - Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Center for Biologics Evaluation and Research, U. S. Food and Drug Administration, Bethesda, Maryland, United States of America Y1 - 2014/01/16/ PY - 2014 DA - 2014 Jan 16 PB - Public Library of Science, 185 Berry Street San Francisco CA 94107 United States VL - 8 IS - 1 SN - 1935-2727, 1935-2727 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Aptamers KW - Parasites KW - Animal models KW - Metabolites KW - Biomarkers KW - Hosts KW - Serology KW - Public health KW - Leishmania donovani KW - Serological studies KW - Antigens KW - Polymerase chain reaction KW - Disease detection KW - Drugs KW - Marine KW - Trypanosoma cruzi KW - Enzyme-linked immunosorbent assay KW - Latin America KW - biomarkers KW - Ocean currents KW - Blood KW - RNA KW - Microscopy KW - Chronic infection KW - Vaccines KW - Trypomastigotes KW - Ligands KW - Chagas' disease KW - K 03410:Animal Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1505332871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Neglected+Tropical+Diseases&rft.atitle=Aptamer+Based%2C+Non-PCR%2C+Non-Serological+Detection+of+Chagas+Disease+Biomarkers+in+Trypanosoma+cruzi+Infected+Mice&rft.au=Nagarkatti%2C+Rana%3Bde+Araujo%2C+Fernanda+Fortes%3BGupta%2C+Charu%3BDebrabant%2C+Alain&rft.aulast=Nagarkatti&rft.aufirst=Rana&rft.date=2014-01-16&rft.volume=8&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Neglected+Tropical+Diseases&rft.issn=19352727&rft_id=info:doi/10.1371%2Fjournal.pntd.0002650 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-03-01 N1 - Last updated - 2016-03-17 N1 - SubjectsTermNotLitGenreText - Ocean currents; Parasites; Serological studies; Antigens; Hosts; Disease detection; Biomarkers; Ligands; Public health; Aptamers; Enzyme-linked immunosorbent assay; Animal models; Metabolites; biomarkers; Serology; Blood; RNA; Chronic infection; Microscopy; Polymerase chain reaction; Vaccines; Trypomastigotes; Drugs; Chagas' disease; Leishmania donovani; Trypanosoma cruzi; Latin America; Marine DO - http://dx.doi.org/10.1371/journal.pntd.0002650 ER - TY - JOUR T1 - Pyridoxylamine reactivity kinetics as an amine based nucleophile for screening electrophilic dermal sensitizers. AN - 1490748803; 24333919 AB - Chemical allergens bind directly, or after metabolic or abiotic activation, to endogenous proteins to become allergenic. Assessment of this initial binding has been suggested as a target for development of assays to screen chemicals for their allergenic potential. Recently we reported a nitrobenzenethiol (NBT) based method for screening thiol reactive skin sensitizers, however, amine selective sensitizers are not detected by this assay. In the present study we describe an amine (pyridoxylamine (PDA)) based kinetic assay to complement the NBT assay for identification of amine-selective and non-selective skin sensitizers. UV-Vis spectrophotometry and fluorescence were used to measure PDA reactivity for 57 chemicals including anhydrides, aldehydes, and quinones where reaction rates ranged from 116 to 6.2 × 10(-6) M(-1) s(-1) for extreme to weak sensitizers, respectively. No reactivity towards PDA was observed with the thiol-selective sensitizers, non-sensitizers and prohaptens. The PDA rate constants correlated significantly with their respective murine local lymph node assay (LLNA) threshold EC3 values (R(2) = 0.76). The use of PDA serves as a simple, inexpensive amine based method that shows promise as a preliminary screening tool for electrophilic, amine-selective skin sensitizers. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. JF - Toxicology AU - Chipinda, Itai AU - Mbiya, Wilbes AU - Adigun, Risikat Ajibola AU - Morakinyo, Moshood K AU - Law, Brandon F AU - Simoyi, Reuben H AU - Siegel, Paul D AD - Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, United States. ; Department of Chemistry, Portland State University, Portland, OR 97207-0751, United States. ; Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, United States. Electronic address: pds3@cdc.gov. Y1 - 2014/01/06/ PY - 2014 DA - 2014 Jan 06 SP - 102 EP - 109 VL - 315 KW - Aldehydes KW - 0 KW - Allergens KW - Anhydrides KW - Quinones KW - Pyridoxamine KW - 6466NM3W93 KW - Index Medicus KW - S(N)1/S(N)2 KW - Pyridoxylamine KW - nitrobenzenethiol KW - Michael acceptor KW - SBF KW - Local lymph node assay KW - Schiff Base Formers KW - acylating agents KW - S(N)Ar KW - Reactivity assay KW - allergic contact dermatitis KW - local lymph node assay KW - AA KW - ACD KW - Nucleophilic Substitution (1 or 2) KW - LLNA KW - pyridoxylamine KW - Skin sensitization KW - PDA KW - NBT KW - Nucleophilic Substitution (aromatic) KW - MA KW - Dermatitis, Allergic Contact -- immunology KW - Spectrometry, Fluorescence KW - Dermatitis, Allergic Contact -- etiology KW - Skin -- metabolism KW - Skin -- immunology KW - Spectrophotometry, Ultraviolet KW - Local Lymph Node Assay KW - Aldehydes -- toxicity KW - Anhydrides -- toxicity KW - Quinones -- toxicity KW - Pyridoxamine -- chemistry KW - Anhydrides -- metabolism KW - Allergens -- metabolism KW - Allergens -- toxicity KW - Aldehydes -- metabolism KW - Quinones -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1490748803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology&rft.atitle=Pyridoxylamine+reactivity+kinetics+as+an+amine+based+nucleophile+for+screening+electrophilic+dermal+sensitizers.&rft.au=Chipinda%2C+Itai%3BMbiya%2C+Wilbes%3BAdigun%2C+Risikat+Ajibola%3BMorakinyo%2C+Moshood+K%3BLaw%2C+Brandon+F%3BSimoyi%2C+Reuben+H%3BSiegel%2C+Paul+D&rft.aulast=Chipinda&rft.aufirst=Itai&rft.date=2014-01-06&rft.volume=315&rft.issue=&rft.spage=102&rft.isbn=&rft.btitle=&rft.title=Toxicology&rft.issn=1879-3185&rft_id=info:doi/10.1016%2Fj.tox.2013.11.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2014-03-03 N1 - Date created - 2014-01-06 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Chem Res Toxicol. 2012 Feb 20;25(2):239-51 [22053936] Chem Res Toxicol. 2004 Mar;17(3):410-5 [15025512] Chem Res Toxicol. 2012 Oct 15;25(10):2203-15 [22950880] Toxicol Sci. 2004 Oct;81(2):332-43 [15254333] Cell Mol Life Sci. 2005 Aug;62(15):1671-81 [15905958] Altern Lab Anim. 2003 Jan-Feb;31(1):7-19 [16221040] Toxicol In Vitro. 2010 Sep;24(6):1465-73 [20624454] Chem Rev. 2011 Apr 13;111(4):2562-96 [21401043] Toxicol In Vitro. 2011 Sep;25(6):1162-8 [21669280] Toxicol In Vitro. 2006 Mar;20(2):239-47 [16112535] Dermatitis. 2005 Dec;16(4):157-202 [16536334] Methods. 2007 Jan;41(1):54-60 [16938465] Chem Biodivers. 2004 Jul;1(7):1073-90 [17191899] Chem Res Toxicol. 2007 Jan;20(1):44-60 [17226926] Toxicol Sci. 2007 Jun;97(2):417-27 [17400584] Chem Res Toxicol. 2007 Jul;20(7):1019-30 [17555332] Toxicol In Vitro. 2007 Oct;21(7):1220-6 [17513083] Chem Res Toxicol. 2008 Feb;21(2):513-20 [18189367] J Appl Toxicol. 2008 May;28(4):443-54 [17703503] Contact Dermatitis. 2008 Aug;59(2):79-89 [18759874] Toxicol Sci. 2008 Dec;106(2):464-78 [18791182] Contact Dermatitis. 2009 Jan;60(1):21-31 [19125718] Amino Acids. 2009 Mar;36(3):437-48 [18480960] Toxicol Sci. 2009 Apr;108(2):401-11 [19221146] Dermatitis. 2010 Jan-Feb;21(1):8-32 [20137736] Chem Res Toxicol. 2010 May 17;23(5):918-25 [20402462] Toxicol Sci. 2010 Jun;115(2):435-43 [20176622] Acta Derm Venereol. 2001 Jan-Feb;81(1):31-4 [11411911] J Appl Toxicol. 2000 May-Jun;20(3):221-30 [10797476] Chem Res Toxicol. 2009 Mar 16;22(3):592-603 [19206519] Int Arch Occup Environ Health. 2003 Jun;76(5):347-50 [12734704] EXS. 2012;101:289-314 [22945573] N1 - Last updated - 2017-01-19 DO - http://dx.doi.org/10.1016/j.tox.2013.11.009 ER - TY - JOUR T1 - Sediment quality of the ecoregion Engure, Gulf of Riga, assessed by using ecotoxicity tests and biomarker responses AN - 1858722871 AB - The aim of this study was to assess sediment quality in the ecoregion Engure, western coast of the Gulf of Riga, by using sediment ecotoxicity tests with amphipods Monoporeia affinis and Pontogammarus robustoides and selected biomarkers (AChE, GST, GR, CAT, MT) measured in Macoma balthica, to represent different types of biological responses reacting to different stressors. Ecoregion Engure sediments are characterised by comparatively low concentrations of heavy metals, and the area could be considered as unpolluted. Ecotoxicity tests of ecoregion Engure sediments did not show statistically significant (> 20% mortality) toxic effects. Survival of test organisms ranged from 83 to 100% and revealed "good quality" of tested sediment. There were no established strong differences between the stations and years regarding biomarkers. The integrated biomarker response index indicated more stressful conditions in station Mersrags, while MT activity revealed heavy metal pollution in station Engure. In general, heavy metal concentrations, ecotoxicity tests and biomarker responses indicate that the ecoregion Engure is not markedly various and anthropogenically affected. JF - Proceedings of the Latvian Academy of Sciences AU - Ieva, Putna AU - Evita, Strode AU - Ieva, Barda AU - Ingrida, Purina AU - Elina, Rimsa AU - Mintauts, Jansons AU - Maija, Balode AU - Solvita, Strake Y1 - 2014 PY - 2014 DA - 2014 SP - 101 EP - 111 CY - Riga PB - De Gruyter Open Sp. z o.o. VL - 68 IS - 1-2 SN - 1407009X KW - Sciences: Comprehensive Works KW - Gulf of Riga KW - biomarkers KW - ecotoxicity tests KW - molluscs KW - amphipods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1858722871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvscijournals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+Latvian+Academy+of+Sciences&rft.atitle=Sediment+quality+of+the+ecoregion+Engure%2C+Gulf+of+Riga%2C+assessed+by+using+ecotoxicity+tests+and+biomarker+responses&rft.au=Ieva%2C+Putna%3BEvita%2C+Strode%3BIeva%2C+Barda%3BIngrida%2C+Purina%3BElina%2C+Rimsa%3BMintauts%2C+Jansons%3BMaija%2C+Balode%3BSolvita%2C+Strake&rft.aulast=Ieva&rft.aufirst=Putna&rft.date=2014-01-01&rft.volume=68&rft.issue=1-2&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+Latvian+Academy+of+Sciences&rft.issn=1407009X&rft_id=info:doi/10.2478%2Fprolas-2014-0009 LA - English DB - ProQuest Central; ProQuest Environmental Science Collection N1 - Copyright - Copyright De Gruyter Open Sp. z o.o. 2014 N1 - Last updated - 2017-02-07 DO - http://dx.doi.org/10.2478/prolas-2014-0009 ER - TY - BOOK T1 - Assessment and detection of loose rock hazards in underground metal mines using thermal imaging AN - 1773800435; 2016-023957 AB - Fall of ground accidents continue to be a source of injury in underground metal mines. MSHA accident statistics indicate that most rock fall accidents occur at a new face where drilling and blasting methods are used. Removing loose rock by scaling is imperative to removing the potential for rock fall injury. Detection of potentially loose rock could improve the scaling process and result in fewer rock falls. Infrared thermal imaging cameras were investigated as far back as 1966 as a tool for loose rock detection. Early on it was clear that sensitivity (e.g. detectable temperature increment) is a key factor in this application. Both pixel resolution and temperature resolution have greatly improved with modern instruments. This paper describes an evaluation of modern infrared thermal imaging camera technology to detect loose rock conditions at six underground metal mines in the western U.S. It was found that thermal images provide a high resolution visual discrimination between loose rock and intact rock. However, detecting loose rock was difficult in cases where the rock and ventilation air were at the same temperature. Loose rock was detected when rock was both warmer and cooler than the ventilation air temperature. Warm rock with cool ventilation air provided the best conditions for detection. JF - 2014 SME annual meeting and exhibit; Leadership in uncertain times AU - Iverson, S AU - Signer, S AU - Anonymous Y1 - 2014 PY - 2014 DA - 2014 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO KW - rock masses KW - rockfalls KW - mining KW - imagery KW - monitoring KW - geologic hazards KW - underground mining KW - site exploration KW - thermal properties KW - mass movements KW - natural hazards KW - room-and-pillar mining KW - risk assessment KW - 27A:Economic geology, geology of ore deposits KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773800435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Iverson%2C+S%3BSigner%2C+S%3BAnonymous&rft.aulast=Iverson&rft.aufirst=S&rft.date=2014-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=Assessment+and+detection+of+loose+rock+hazards+in+underground+metal+mines+using+thermal+imaging&rft.title=Assessment+and+detection+of+loose+rock+hazards+in+underground+metal+mines+using+thermal+imaging&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 2014 SME annual meeting and exhibit; Leadership in uncertain times N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - Number of references - 11 N1 - PubXState - CO N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2016-03-17 ER - TY - BOOK T1 - A generalized method for calculating pillar cell capacities for boundary element modeling of coal mines AN - 1773800190; 2016-023960 AB - The problem of estimating pillar capacity in coal mines has motivated development of a variety of empirical equations. Most of these equations have arisen from experience and a very limited set of measurements that have, necessarily, been focused on particular regions or coal fields. Their applicability is often limited to a specific range of pillar sizes. This is of particular concern in the design of large gateroad pillars and small barrier pillars between panels. The result has been a variety of equations and equation coefficients that can calculate load estimates to size pillars. Inclusion of these equations in more sophisticated loading models, such as boundary element methods (e.g. LaModel and MULSIM) has been hampered by absence of a function that describes specific variation of coal strength within the pillar. A singular exception, to our knowledge, is a function corresponding to the Bieniawski pillar strength equation. Because of this, it is the only coal strength criteria inherently available in most boundary element models. This paper presents a general method for deriving local coal strength, as a function of distance from the pillar rib, for an arbitrary pillar strength equation. Integration of this function provides the strength of pillar regions, or cells, needed for boundary element models. The method is demonstrated for the Bieniawski, Maleki and Holland-Gaddy equations. The Maleki and Holland-Gaddy equations contrast strongly with Bieniawski as strengths are extrapolated to large pillars and barriers. This development provides a tool for incorporating any of the proposed empirical equations into a boundary element model, thereby allowing the analyst to choose the most appropriate equation for a particular region, coal seam and/or pillar size. JF - 2014 SME annual meeting and exhibit; Leadership in uncertain times AU - Johnson, J C AU - Whyatt, J K AU - Loken, M C AU - Anonymous Y1 - 2014 PY - 2014 DA - 2014 PB - Society for Mining, Metallurgy, and Exploration, Littleton, CO KW - mining KW - underground mining KW - bearing capacity KW - strength KW - loading KW - stress KW - coal seams KW - rock mechanics KW - boundary element analysis KW - sedimentary rocks KW - elastoplastic materials KW - coal KW - pillars KW - 30:Engineering geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1773800190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/GeoRef&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Johnson%2C+J+C%3BWhyatt%2C+J+K%3BLoken%2C+M+C%3BAnonymous&rft.aulast=Johnson&rft.aufirst=J&rft.date=2014-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=A+generalized+method+for+calculating+pillar+cell+capacities+for+boundary+element+modeling+of+coal+mines&rft.title=A+generalized+method+for+calculating+pillar+cell+capacities+for+boundary+element+modeling+of+coal+mines&rft.issn=&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - 2014 SME annual meeting and exhibit; Leadership in uncertain times N1 - Copyright - GeoRef, Copyright 2016, American Geosciences Institute. N1 - Date revised - 2016-01-01 N1 - Number of references - 12 N1 - PubXState - CO N1 - Document feature - illus. N1 - Last updated - 2016-03-17 ER - TY - JOUR T1 - Analytical techniques and bioactivity assays to compare the structure and function of filgrastim (granulocyte-colony stimulating factor) therapeutics from different manufacturers AN - 1746889562; 21140080 AB - The FDA has approved more than 100 protein and peptide drugs with hundreds more in the pipeline (Lanthier et al. in Nat Rev Drug Discov 7(9):733-737, 2008). Many of these originator biologic products are now coming off patent and are being manufactured by alternate methods than the innovator as follow-on drugs. Because changes to the production method often lead to subtle differences (e.g., degradation products, different posttranslational modifications or impurities) in the therapeutic (Schiestl et al. in Nat Biotechnol 29(4):310-312, 2011), there is a critical need to define techniques to test and insure the quality of these drugs. In addition, the emergence of protein therapeutics manufactured by unapproved methodologies presents an ongoing and growing regulatory challenge. In this work, high-resolution mass spectrometry was used to determine the presence or absence of post-translational modifications for one FDA-approved and three foreign-sourced, unapproved filgrastim products. Circular dichroism (CD) was used to compare the secondary structure and probe the temperature stability of these products. Native 2D super(1)H, super(15)N-hetero nuclear singular quantum coherence (HSQC) NMR test was applied to these samples to compare the higher-order structure of the four products. Finally, a cell proliferation assay was performed on the filgrastims to compare their bioactivity, and stressed filgrastim was tested in the bioassay to better understand the effects of changes in protein structure on activity. The results showed that orthogonal approaches are capable of characterizing the physiochemical properties of this protein dmg and assessing the impact of structural changes on filgrastim purity and potency. JF - Analytical and Bioanalytical Chemistry AU - Levy, Michaella J AU - Gucinski, Ashley C AU - Sommers, Cynthia D AU - Ghasriani, Houman AU - Wang, Bo AU - Keire, David A AU - Boyne, Michael T, II AD - Division of Pharmaceutical Analysis, Office of Testing and Research, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, 645 S. Newstead Ave, St. Louis, MO 63110, USA, michael.boyne@fda.hhs.gov PY - 2014 SP - 6559 EP - 6567 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 406 IS - 26 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Top-down mass spectrometry KW - Granulocyte-colony stimulating factor KW - Bioassay KW - Cell proliferation KW - Circular dichroism KW - NMR KW - Testing Procedures KW - Mass Spectrometry KW - Patents KW - Toxicity KW - Assay KW - Proteins KW - Pipelines KW - Drugs KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746889562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Analytical+techniques+and+bioactivity+assays+to+compare+the+structure+and+function+of+filgrastim+%28granulocyte-colony+stimulating+factor%29+therapeutics+from+different+manufacturers&rft.au=Levy%2C+Michaella+J%3BGucinski%2C+Ashley+C%3BSommers%2C+Cynthia+D%3BGhasriani%2C+Houman%3BWang%2C+Bo%3BKeire%2C+David+A%3BBoyne%2C+Michael+T%2C+II&rft.aulast=Levy&rft.aufirst=Michaella&rft.date=2014-01-01&rft.volume=406&rft.issue=26&rft.spage=6559&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-014-7469-x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 21 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Testing Procedures; Mass Spectrometry; Patents; Assay; Proteins; Pipelines; Toxicity; Drugs DO - http://dx.doi.org/10.1007/s00216-014-7469-x ER - TY - JOUR T1 - Mass spectrometric analysis of pharmaceutical adulterants in products labeled as botanical dietary supplements or herbal remedies: a review AN - 1746888903; 21117046 AB - The increased availability and use of botanical dietary supplements and herbal remedies among consumers has been accompanied by an increased frequency of adulteration of these products with synthetic pharmaceuticals. Unscrupulous producers may add drugs and analogues of various classes, such as phosphodiesterase type 5 (PDE-5) inhibitors, weight loss, hypoglycemic, antihypertensive and antiinflammatory agents, or anabolic steroids, to develop or intensify biological effects of dietary supplements or herbal remedies. The presence of such adulterated products in the marketplace is a worldwide problem and their consumption poses health risks to consumers. Analytical methods that allow rapid and reliable testing of dietary supplements for the presence of synthetic drugs are needed to address such fraudulent practices. Mass spectrometry (MS) and hyphenated techniques such as liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GCMS) have become primary tools in this endeavor. The present review critically assesses the role and summarizes the applications of MS in the analysis of pharmaceutical adulterants in botanical dietary supplements and herbal remedies. The uses of MS techniques in detection, confirmation, and quantification of known pharmaceutical adulterants as well as in screening for and structure elucidation of unexpected adulterants and novel designer drugs are discussed. JF - Analytical and Bioanalytical Chemistry AU - Vaclavik, Lukas AU - Krynitsky, Alexander J AU - Rader, Jeanne I AD - US Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, 5100 Paint Branch Parkway, HFS-717, College Park, MD 20740, USA, Lukas.vaclavik@fda.hhs.gov PY - 2014 SP - 6767 EP - 6790 PB - Springer Science+Business Media, Van Godewijckstraat 30 Dordrecht 3311 GX Netherlands VL - 406 IS - 27 SN - 1618-2642, 1618-2642 KW - Aqualine Abstracts; Water Resources Abstracts KW - Botanical dietary supplements KW - Herbal remedies KW - Adulteration KW - Pharmaceuticals KW - Mass spectrometry KW - Mass Spectrometry KW - Remedies KW - Risk KW - Public Health KW - Weight KW - Analytical Methods KW - Reviews KW - Drugs KW - AQ 00001:Water Resources and Supplies KW - SW 0810:General UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1746888903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+and+Bioanalytical+Chemistry&rft.atitle=Mass+spectrometric+analysis+of+pharmaceutical+adulterants+in+products+labeled+as+botanical+dietary+supplements+or+herbal+remedies%3A+a+review&rft.au=Vaclavik%2C+Lukas%3BKrynitsky%2C+Alexander+J%3BRader%2C+Jeanne+I&rft.aulast=Vaclavik&rft.aufirst=Lukas&rft.date=2014-01-01&rft.volume=406&rft.issue=27&rft.spage=6767&rft.isbn=&rft.btitle=&rft.title=Analytical+and+Bioanalytical+Chemistry&rft.issn=16182642&rft_id=info:doi/10.1007%2Fs00216-014-8159-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-12-01 N1 - Number of references - 115 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Risk; Mass Spectrometry; Public Health; Weight; Analytical Methods; Reviews; Remedies; Drugs DO - http://dx.doi.org/10.1007/s00216-014-8159-z ER - TY - JOUR T1 - The cancer mortality and incidence experience of workers at British Nuclear Fuels plc, 1946-2005 AN - 1735916614; PQ0002164911 AB - The aim of this study was to estimate cancer mortality and incidence risk associated with external radiation exposure in the BNFL cohort of nuclear workers and to determine if these risks are modified by potential for internal exposure. External radiation exposures as measured by personal dosimeters (generally 'film badges') were available for 42431 individuals classified as 'radiation workers'. This analysis found an increased risk of all cancers associated with external occupational radiation exposure (ERR/Gy = 0.34 90% CI: 0.07; 0.64), with significant excess risks observed for all solid cancers (ERR/Gy = 0.29 90% CI: 0.02; 0.59) and leukaemia excluding CLL (ERR/Gy = 2.60 90% CI: 0.28; 7.01). The overall cancer risk estimates are consistent with values used by national and international bodies in setting radiation protection standards. Categorical analyses also revealed that the difference in the dose response relationship between the two groups is only apparent for those exposed to cumulative external doses in excess of 200 mGy. JF - Journal of Radiological Protection AU - Gillies, Michael AU - Haylock, Richard AD - Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Moor Row, Cumbria CA24 3HU, michael.gillies@phe.gov.uk PY - 2014 SP - 595 EP - 623 PB - IOP Publishing, The Public Ledger Building, Suite 929 Philadelphia PA 19106 United States VL - 34 IS - 3 SN - 0952-4746, 0952-4746 KW - Risk Abstracts; Health & Safety Science Abstracts KW - ionising radiation KW - cancer mortality KW - cancer incidence KW - cohort study KW - occupational exposure KW - Health risks KW - Mortality KW - Leukemia KW - Radiation KW - Nuclear fuels KW - Occupational exposure KW - Cancer KW - International standardization KW - R2 23060:Medical and environmental health KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1735916614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Radiological+Protection&rft.atitle=The+cancer+mortality+and+incidence+experience+of+workers+at+British+Nuclear+Fuels+plc%2C+1946-2005&rft.au=Gillies%2C+Michael%3BHaylock%2C+Richard&rft.aulast=Gillies&rft.aufirst=Michael&rft.date=2014-01-01&rft.volume=34&rft.issue=3&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=Journal+of+Radiological+Protection&rft.issn=09524746&rft_id=info:doi/10.1088%2F0952-4746%2F34%2F3%2F595 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-11-01 N1 - Last updated - 2015-12-09 N1 - SubjectsTermNotLitGenreText - Leukemia; Mortality; Health risks; Radiation; Nuclear fuels; Cancer; Occupational exposure; International standardization DO - http://dx.doi.org/10.1088/0952-4746/34/3/595 ER - TY - JOUR T1 - Noncoding RNA response to xenobiotic exposure: an indicator of toxicity and carcinogenicity AN - 1722173648; PQ0002097525 AB - Introduction: Human exposure to certain environmental and occupational chemicals is one of the major risk factors for noncommunicable diseases, including cancer. Therefore, it is desirable to take advantage of subtle exposure-related adverse cellular events for early disease detection and to identify potential dangers caused by new and currently under-evaluated drugs and chemicals. Nongenotoxic events due to carcinogen/toxicant exposure are a general hallmark of sustained cellular stress leading to tumorigenesis. These processes are globally regulated via noncoding RNAs (ncRNAs). Tumorigenesis-associated genotoxic and nongenotoxic events lead to the altered expression of ncRNAs and may provide a mechanistic link between chemical exposure and tumorigenesis. Current advances in toxicogenomics are beginning to provide valuable insight into gene-chemical interactions at the transcriptome level. Areas covered: In this review, we summarize recent information about the impact of xenobiotics on ncRNAs. Evidence highlighted in this review suggests a critical role of ncRNAs in response to carcinogen/toxicant exposure. Expert opinion: Benefits for the use of ncRNAs in carcinogenicity assessment include remarkable tissue specificity, early appearance, low baseline variability, and their presence and stability in biological fluids, which suggests that the incorporation of ncRNAs in the evaluation of cancer risk assessment may enhance substantially the efficiency of toxicity and carcinogenicity testing. JF - Expert Opinion on Drug Metabolism and Toxicology AU - Marrone, April K AU - Beland, Frederick A AU - Pogribny, Igor P AD - National Center for Toxicological Research, Division of Biochemical Toxicology, Jefferson, AR, USA PY - 2014 SP - 1409 EP - 1422 PB - Informa Healthcare VL - 10 IS - 10 SN - 1742-5255, 1742-5255 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - long noncoding RNAs KW - microRNAs KW - noncoding RNAs KW - xenobiotics KW - Risk assessment KW - Toxicants KW - Carcinogenicity testing KW - Tumorigenesis KW - Genotoxicity KW - non-coding RNA KW - Stress KW - Carcinogens KW - Toxicity KW - Cancer KW - Gene expression KW - RNA KW - Carcinogenicity KW - Risk factors KW - Reviews KW - Occupational exposure KW - N 14830:RNA KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1722173648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.atitle=Noncoding+RNA+response+to+xenobiotic+exposure%3A+an+indicator+of+toxicity+and+carcinogenicity&rft.au=Marrone%2C+April+K%3BBeland%2C+Frederick+A%3BPogribny%2C+Igor+P&rft.aulast=Marrone&rft.aufirst=April&rft.date=2014-01-01&rft.volume=10&rft.issue=10&rft.spage=1409&rft.isbn=&rft.btitle=&rft.title=Expert+Opinion+on+Drug+Metabolism+and+Toxicology&rft.issn=17425255&rft_id=info:doi/10.1517%2F17425255.2014.954312 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-10-01 N1 - Last updated - 2016-01-21 N1 - SubjectsTermNotLitGenreText - Risk assessment; Toxicants; Carcinogenicity testing; Genotoxicity; Tumorigenesis; non-coding RNA; Stress; Toxicity; Carcinogens; Cancer; Gene expression; RNA; Carcinogenicity; Reviews; Risk factors; Occupational exposure DO - http://dx.doi.org/10.1517/17425255.2014.954312 ER - TY - JOUR T1 - Pay attention on test article analysis in nonclinical Safety Evaluation of new drugs AN - 1709177891; 20972765 AB - This paper discusses test article analysis in nonclinical safety study of new drugs to obtain reliable data. JF - Zhongguo Linchuang Yaolixue Zazhi - The Chinese Journal of Clinical Pharmacology AU - HU, Xiao-min AU - WANG, Qing-li AD - Center for Drug Evaluation, China Food and Drug Administration, Beijing 100038, China, huxm@cde.org.cn Y1 - 2014 PY - 2014 DA - 2014 SP - 838 EP - 839 PB - Zhongguo Linchuang Yaolixue Zazhi VL - 30 IS - 9 SN - 1001-6821, 1001-6821 KW - Biotechnology and Bioengineering Abstracts KW - nonclinical safety study KW - test article analysis KW - Data processing KW - Drug development KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1709177891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Zhongguo+Linchuang+Yaolixue+Zazhi+-+The+Chinese+Journal+of+Clinical+Pharmacology&rft.atitle=Pay+attention+on+test+article+analysis+in+nonclinical+Safety+Evaluation+of+new+drugs&rft.au=HU%2C+Xiao-min%3BWANG%2C+Qing-li&rft.aulast=HU&rft.aufirst=Xiao-min&rft.date=2014-01-01&rft.volume=30&rft.issue=9&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Zhongguo+Linchuang+Yaolixue+Zazhi+-+The+Chinese+Journal+of+Clinical+Pharmacology&rft.issn=10016821&rft_id=info:doi/10.13699%2Fj.cnki.1001-6821.2014.09.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-09-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Data processing; Drug development; Drugs DO - http://dx.doi.org/10.13699/j.cnki.1001-6821.2014.09.028 ER - TY - JOUR T1 - Comparative Evaluation of Light-Emitting Diode Cap Lamps With an Emphasis on Visual Performance in Mesopic Lighting Conditions AN - 1705064614; PQ0001417411 AB - Conducted at the National Institute for Occupational Safety and Health's (NIOSH) Office of Mine Safety and Health Research, the experiment described in this paper is part of ongoing mine illumination research designed to explore the benefits of solid-state lighting technologies when applied to the underground mining industry. This experiment involves the comparative evaluation of cap lamps with similar spectral power distributions, focusing on the electrical and battery discharge characteristics, with a secondary objective being the benefits gained through alternative light beam distributions. NIOSH researchers conducted the investigation by comparing three commercially available light-emitting diode cap lamps and an NIOSH prototype cap lamp at varying power settings. Visual performance for the detection of hazards was quantified by recording times of detection for finding rotating targets in the peripheral field of view and objects representing trip and fall hazards on the ground. The NIOSH prototype cap lamp resulted in improvements ranging from 15% to 43% for peripheral motion detection time and 5%-23% for slip, trip, and fall object detection time, respectively, as compared with the referent incandescent cap lamp. JF - IEEE Transactions on Industry Applications AU - Reyes, Miguel A AU - Sammarco, John J AU - Gallagher, Sean AU - Srednicki, Justin R AD - National Institute for Occupational Safety and Health, Pittsburgh, PA, USA Y1 - 2014/01// PY - 2014 DA - Jan 2014 SP - 127 EP - 133 PB - Institute of Electrical and Electronics Engineers, Inc., 345 E. 47th St. NY NY 10017-2394 United States VL - 50 IS - 1 SN - 0093-9994, 0093-9994 KW - Health & Safety Science Abstracts KW - Batteries KW - Prototypes KW - Safety KW - Occupational safety KW - Lighting KW - Mining KW - Mines KW - Recording KW - Technology KW - H 1000:Occupational Safety and Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1705064614?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Transactions+on+Industry+Applications&rft.atitle=Comparative+Evaluation+of+Light-Emitting+Diode+Cap+Lamps+With+an+Emphasis+on+Visual+Performance+in+Mesopic+Lighting+Conditions&rft.au=Reyes%2C+Miguel+A%3BSammarco%2C+John+J%3BGallagher%2C+Sean%3BSrednicki%2C+Justin+R&rft.aulast=Reyes&rft.aufirst=Miguel&rft.date=2014-01-01&rft.volume=50&rft.issue=1&rft.spage=127&rft.isbn=&rft.btitle=&rft.title=IEEE+Transactions+on+Industry+Applications&rft.issn=00939994&rft_id=info:doi/10.1109%2FTIA.2013.2291294 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2015-08-01 N1 - Last updated - 2015-09-03 N1 - SubjectsTermNotLitGenreText - Batteries; Prototypes; Occupational safety; Safety; Lighting; Mining; Mines; Technology; Recording DO - http://dx.doi.org/10.1109/TIA.2013.2291294 ER - TY - JOUR T1 - Addressing the Specific Behavioral Health Needs of Men AN - 1700672467; 201505780 JF - Journal of Social Work Practice in the Addictions AU - Steen, Jeff T AU - Steen, Jeff T Y1 - 2014///0, PY - 2014 DA - 0, 2014 SP - 208 EP - 210 PB - Taylor & Francis, Philadelphia PA VL - 14 IS - 2 SN - 1533-256X, 1533-256X KW - article KW - 6129: addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1700672467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=Journal+of+Social+Work+Practice+in+the+Addictions&rft.atitle=Addressing+the+Specific+Behavioral+Health+Needs+of+Men&rft.au=Steen%2C+Jeff+T%3BSubstance+Abuse+and+Mental+Health+Services+Administration&rft.aulast=Steen&rft.aufirst=Jeff&rft.date=2014-01-01&rft.volume=14&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Journal+of+Social+Work+Practice+in+the+Addictions&rft.issn=1533256X&rft_id=info:doi/10.1080%2F1533256X.2014.902254 LA - English DB - Social Services Abstracts N1 - Date revised - 2015-08-01 N1 - SuppNotes - Edition date: 2013. N1 - Last updated - 2016-09-28 DO - http://dx.doi.org/10.1080/1533256X.2014.902254 ER - TY - BOOK T1 - Trauma-informed care in behavioral health services T2 - Treatment improvement protocol (TIP) series, 57 AN - 1686991987; 88297 AB - Many individuals experience trauma during their lifetimes. Although many people exposed to trauma demonstrate few or no lingering symptoms, those individuals who have experienced repeated, chronic, or multiple traumas are more likely to exhibit pronounced symptoms and consequences, including substance abuse, mental illness, and health problems. Subsequently, trauma can significantly affect how an individual engages in major life areas as well as treatment. This TIP provides evidence-based and best practice information for behavioral health service providers and administrators who want to work more effectively with people who have been exposed to acute and chronic traumas and/or are at risk of developing traumatic stress reactions. Using key trauma-informed principles, this TIP addresses trauma-related prevention, intervention, and treatment issues and strategies in behavioral health services. The content is adaptable across behavioral health settings that service individuals, families, and communities--placing emphasis on the importance of coordinating as well as integrating services. [Adapted from Preface] JF - Rockville MD: Substance Abuse and Mental Health Services Administration, 2014. xix, 319 pp. AU - (U.S.), Center for Substance Abuse Treatment PY - 2014 SP - 2 EP - xix, 319 PB - Substance Abuse and Mental Health Services Administration KW - Professional Training KW - Treatment KW - Evidence Based Treatment KW - PTSD KW - Survivors KW - Literature Review KW - Assessment KW - Psychiatric Disorders KW - Comorbidity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1686991987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/PILOTS%3A+Published+International+Literature+On+Traumatic+Stress&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=%28U.S.%29%2C+Center+for+Substance+Abuse+Treatment&rft.aulast=%28U.S.%29&rft.aufirst=Center+for+Substance+Abuse&rft.date=2014-01-01&rft.volume=&rft.issue=&rft.spage=xix&rft.isbn=&rft.btitle=Trauma-informed+care+in+behavioral+health+services&rft.title=Trauma-informed+care+in+behavioral+health+services&rft.issn=&rft_id=info:doi/ LA - English DB - PILOTS: Published International Literature On Traumatic Stress N1 - Date revised - 2016-09-15 N1 - SuppNotes - Part 3 of this publication, a literature review on trauma informed care, is only available in the online version in order to facilitate ongoing updates which are performed for up to 3 years from first publication.; TIP 57 may be ordered or downloaded from SAMHSA's Publications Ordering Web page at http://store.samhsa.gov N1 - Last updated - 2016-09-15 ER - TY - JOUR T1 - National Library of Medicine Disaster Information Management Research Center: Achieving the vision, 2010-2013 AN - 1680140076; 201503986 AB - From 2010 to 2013, the National Library of Medicine (NLM) Disaster Information Management Research Center (DIMRC) continued to build its programs and services on the foundation laid in its starting years, 20082010. Prior to 2008, NLM had a long history of providing health information, training, and tools in response to disasters. Aware of this legacy, the NLM long range plan (Charting a Course for the 21st Century: NLM's Long Range Plan 20062016) called for creation of a center to show a strong commitment to disaster remediation and to provide a platform for demonstrating how libraries and librarians can be part of the solution to this national problem. NLM is continuing efforts to ensure that medical libraries have plans for the continuity of their operations, librarians are trained to understand their roles in preparedness and response, online disaster health information resources are available for many audiences and in multiple formats, and research is conducted on tools to enhance the exchange of critical information during and following disasters. This paper describes the 2010-2013 goals and activities of DIMRC and its future plans. Adapted from the source document. JF - Information Services & Use AU - Love, Cynthia B AU - Arnesen, Stacey J AU - Phillips, Steven J AU - Windom, Robert E AD - Disaster Information Management Research Center, Specialized Information Services Division, National Library of Medicine, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA Y1 - 2014///0, PY - 2014 DA - 0, 2014 SP - 149 EP - 170 PB - IOS Press, Amsterdam, The Netherlands VL - 34 IS - 1-2 SN - 0167-5265, 0167-5265 KW - National Library of Medicine KW - Disaster Information Management Research Center KW - history KW - preparedness KW - response KW - recovery KW - medicine KW - disasters KW - public health emergencies KW - emergency management KW - libraries KW - librarians KW - informationists KW - Bethesda Hospitals' Emergency Preparedness Partnership KW - hazards KW - databases KW - Internet KW - Web KW - research and development KW - WISER KW - REMM KW - CHEMM KW - Disaster Lit KW - Resource Guide for Disaster Medicine and Public Health KW - Resource Guide for Public Health Preparedness KW - National Network of Libraries of Medicine KW - NN/LM KW - Research centers KW - National libraries KW - Disasters KW - Medical libraries KW - article KW - 3.19: SCIENCE, TECHNOLOGY, MEDICINE LIBRARIES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1680140076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Information+Services+%26+Use&rft.atitle=National+Library+of+Medicine+Disaster+Information+Management+Research+Center%3A+Achieving+the+vision%2C+2010-2013&rft.au=Love%2C+Cynthia+B%3BArnesen%2C+Stacey+J%3BPhillips%2C+Steven+J%3BWindom%2C+Robert+E&rft.aulast=Love&rft.aufirst=Cynthia&rft.date=2014-01-01&rft.volume=34&rft.issue=1-2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Information+Services+%26+Use&rft.issn=01675265&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2015-06-01 N1 - Last updated - 2016-09-27 N1 - CODEN - ISUSDX N1 - SubjectsTermNotLitGenreText - Research centers; National libraries; Disasters; Medical libraries ER - TY - JOUR T1 - Synthesis and cytotoxicity studies of Hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents AN - 1678018992; 19387719 AB - Cancer-related death is one of the most common causes of mortality in society. Small molecules have the capability to disrupt aberrant signaling pathways in tumors, leading to anticancer activities. Therefore the search for new molecules for cancer treatment continues to draw attention to the scientific research community. Synthesis and biological evaluation of hedgehog (Hh) pathway inhibitors SANT-1 and GANT-61 are disclosed. These molecules have been synthesized from common precursors using simple conversions, our synthesis features Vils-Meier-Haack reaction, imine formation reaction and N-arylation reaction. These drugs were evaluated using a Hh reporter assay to confirm pathway inhibitory activity, and tested for cell viability against pancreatic and prostate cancer cells. These methodologies can be applied to make potent analogs of both inhibitors. JF - Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering AU - Chenna, Venugopal AU - Hu, Chaoxin AU - Khan, Saeed R AD - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Y1 - 2014 PY - 2014 DA - 2014 SP - 641 EP - 647 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN United Kingdom VL - 49 IS - 6 SN - 1093-4529, 1093-4529 KW - Environmental Engineering Abstracts (EN); CSA / ASCE Civil Engineering Abstracts (CE) KW - Pathways KW - Searching KW - Inhibitors KW - Enzymes KW - Synthesis KW - Drugs KW - Anticancer properties KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1678018992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aenvironmentalengabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+A%3A+Toxic%2FHazardous+Substances+%26+Environmental+Engineering&rft.atitle=Synthesis+and+cytotoxicity+studies+of+Hedgehog+enzyme+inhibitors+SANT-1+and+GANT-61+as+anticancer+agents&rft.au=Chenna%2C+Venugopal%3BHu%2C+Chaoxin%3BKhan%2C+Saeed+R&rft.aulast=Chenna&rft.aufirst=Venugopal&rft.date=2014-01-01&rft.volume=49&rft.issue=6&rft.spage=641&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+A%3A+Toxic%2FHazardous+Substances+%26+Environmental+Engineering&rft.issn=10934529&rft_id=info:doi/10.1080%2F10934529.2014.865425 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-05-01 N1 - Last updated - 2015-05-04 DO - http://dx.doi.org/10.1080/10934529.2014.865425 ER - TY - JOUR T1 - Induced earthquakes from the 2013 Bingham Canyon landslides AN - 1676587430; 2015-037565 AB - On 11 April 2013 two massive rock avalanches, separated in time by 1.5 hours, occurred at the Bingham Canyon mine (BCM) southwest of Salt Lake City, UT. Seismic and infrasound data from the landslides were well recorded by the Utah Regional Seismic Network (URSN). Following the slides, four small (M (sub L) < or =2.5) earthquakes were detected and located in the mine area using routine URSN procedures. Initial waveform cross-correlation analysis using continuous data for the month of April 2013 identified 12 additional seismic events, beginning just after the first slide and decreasing in frequency over 10 days. To better assess seismic activity near the mine both the URSN catalog and continuous data from seven nearby (<20 km) seismic stations were analyzed. From the catalog analysis, using time of day to discriminate between earthquakes and blasts, approximately 20-30 earthquakes were located near the BCM since January 1981. Using waveform cross-correlation between the four earthquakes detected immediately following the landslides and 690 events in the URSN catalog located near BCM between 1 October 2012 and 8 November 2013, we found only one event on 22 January 2013 that had similar waveforms, suggesting a similar location and mechanism to the original four earthquakes. Again using the four originally detected earthquakes, plus the January 2013 event as templates, waveforms were cross-correlated against one year of continuous data beginning 1 January 2013. This analysis identified 21 (including 12 from the initial analysis) earthquakes (-0.8